WorldWideScience

Sample records for methodology oriented treatment

  1. Methodological foundations of target market enterprise orientation

    OpenAIRE

    N.V. Karpenko

    2012-01-01

    In the article the author determines the importance of target market orientation maintenance which content is based on marketing principles and envisages the interrelationship of market segmentation processes and positioning. Proposed methodological principles of segmentation implementation are the result of the authors own research, and the process of positioning is examined through the five-level system that contains three stages and two variants of organizational behavior.

  2. Case Study Research: Foundations and Methodological Orientations

    Directory of Open Access Journals (Sweden)

    Helena Harrison

    2017-01-01

    Full Text Available Over the last forty years, case study research has undergone substantial methodological development. This evolution has resulted in a pragmatic, flexible research approach, capable of providing comprehensive in-depth understanding of a diverse range of issues across a number of disciplines. Change and progress have stemmed from parallel influences of historical transformations in approaches to research and individual researcher's preferences, perspectives, and interpretations of this design. Researchers who have contributed to the development of case study research come from diverse disciplines with different philosophical perspectives, resulting in a variety of definitions and approaches. For the researcher new to using case study, such variety can create a confusing platform for its application. In this article, we explore the evolution of case study research, discuss methodological variations, and summarize key elements with the aim of providing guidance on the available options for researchers wanting to use case study in their work. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1701195

  3. Developing Agent-Oriented Video Surveillance System through Agent-Oriented Methodology (AOM

    Directory of Open Access Journals (Sweden)

    Cheah Wai Shiang

    2016-12-01

    Full Text Available Agent-oriented methodology (AOM is a comprehensive and unified agent methodology for agent-oriented software development. Although AOM is claimed to be able to cope with a complex system development, it is still not yet determined up to what extent this may be true. Therefore, it is vital to conduct an investigation to validate this methodology. This paper presents the adoption of AOM in developing an agent-oriented video surveillance system (VSS. An intruder handling scenario is designed and implemented through AOM. AOM provides an alternative method to engineer a distributed security system in a systematic manner. It presents the security system at a holistic view; provides a better conceptualization of agent-oriented security system and supports rapid prototyping as well as simulation of video surveillance system.

  4. An aspect-oriented methodology for designing secure applications

    NARCIS (Netherlands)

    Georg, Geri; Ray, Indrakshi; Anastasakis, Kyriakos; Bordbar, Behzad; Toahchoodee, Manachai; Houmb, S.H.

    We propose a methodology, based on aspect-oriented modeling (AOM), for incorporating security mechanisms in an application. The functionality of the application is described using the primary model and the attacks are specified using aspects. The attack aspect is composed with the primary model to

  5. Validating agent oriented methodology (AOM) for netlogo modelling and simulation

    Science.gov (United States)

    WaiShiang, Cheah; Nissom, Shane; YeeWai, Sim; Sharbini, Hamizan

    2017-10-01

    AOM (Agent Oriented Modeling) is a comprehensive and unified agent methodology for agent oriented software development. AOM methodology was proposed to aid developers with the introduction of technique, terminology, notation and guideline during agent systems development. Although AOM methodology is claimed to be capable of developing a complex real world system, its potential is yet to be realized and recognized by the mainstream software community and the adoption of AOM is still at its infancy. Among the reason is that there are not much case studies or success story of AOM. This paper presents two case studies on the adoption of AOM for individual based modelling and simulation. It demonstrate how the AOM is useful for epidemiology study and ecological study. Hence, it further validate the AOM in a qualitative manner.

  6. NPA4K development system using object-oriented methodology

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Kwang Seong; Hahn, Do Hee

    2000-11-01

    NPA4K consists of module programs with several components for various functions. Software components have to be developed systematically by compartment criteria and design method. In this paper, the understandings of a typical Object-Oriented Methodology , UML(Unified Modeling Language), the procedure for NPA4K program development and the architecture for long-term development of NPA4K are introduced.

  7. NPA4K development system using object-oriented methodology

    International Nuclear Information System (INIS)

    Jeong, Kwang Seong; Hahn, Do Hee

    2000-11-01

    NPA4K consists of module programs with several components for various functions. Software components have to be developed systematically by compartment criteria and design method. In this paper, the understandings of a typical Object-Oriented Methodology , UML(Unified Modeling Language), the procedure for NPA4K program development and the architecture for long-term development of NPA4K are introduced

  8. Towards a general object-oriented software development methodology

    Science.gov (United States)

    Seidewitz, ED; Stark, Mike

    1986-01-01

    Object diagrams were used to design a 5000 statement team training exercise and to design the entire dynamics simulator. The object diagrams are also being used to design another 50,000 statement Ada system and a personal computer based system that will be written in Modula II. The design methodology evolves out of these experiences as well as the limitations of other methods that were studied. Object diagrams, abstraction analysis, and associated principles provide a unified framework which encompasses concepts from Yourdin, Booch, and Cherry. This general object-oriented approach handles high level system design, possibly with concurrency, through object-oriented decomposition down to a completely functional level. How object-oriented concepts can be used in other phases of the software life-cycle, such as specification and testing is being studied concurrently.

  9. Oriental Medical Treatment of Lumbar Spinal Stenosis

    Directory of Open Access Journals (Sweden)

    Hae-Yeon Lee

    2003-12-01

    Full Text Available Lumbar spinal stenosis results from the progressive combined narrowing of the central spinal canal, the neurorecesses, and the neuroforaminal canals. In the absence of prior surgery, tumor, or infection, the spinal canal may become narrowed by bulging or protrusion of the intervertebral disc annulus, herniation of the nucleus pulposis posteriorly, thickening of the posterior longitudinal ligament, hypertrophy of the ligamentum flavum, epidural fat deposition, spondylosis of the intervertebral disc margins, or a combination of two or more of the above factors. Patients with spinal stenosis become symptomatic when pain, motor weakness, paresthesia, or other neurologic compromise causes distress. In one case, we administrated oriental medical treatment with acupuncture treatment and herb-medicine. Oriental medical treatment showed desirable effect on lumbar spinal stenosis.

  10. Teaching Research Methodologies to Professionally Oriented Honors Students

    Science.gov (United States)

    Levinson, Julie; Mandel, Richard

    2013-01-01

    The benefits of encouraging undergraduate students to pursue independent research have been well documented (Craney; Guterman; Hathaway et al.; Ishiyama; Kremer and Bringle; Volkwein and Carbone). Introducing students to research processes and protocols is always a challenge, particularly for students enrolled in professionally oriented,…

  11. Methodological Support for Service-oriented Design with ISDL

    NARCIS (Netherlands)

    Quartel, Dick; Dijkman, R.M.; van Sinderen, Marten J.

    2004-01-01

    Currently, service-oriented computing is mainly technology-driven. Most developments focus on the technology that enables enterprises to describe, publish and compose application services, and to communicate with applications of other enterprises according to their service descriptions. In this

  12. Process-oriented Design Methodology for the (Inter-) Organizational Intellectual Capital Management

    OpenAIRE

    Galeitzke, Mila; Oertwig, Nicole; Orth, Ronald; Kohl, Holger

    2016-01-01

    The development of a process-oriented design methodology for the visualization of intellectual capital in organisational business processes is described in this contribution. A tangible and intangible resource-oriented taxonomy in an integrated enterprise modelling environment is established. The comprehensive assessment, allocation and referencing of intellectual capital (human, structural and relational capital) counters the underutilization of available intellectual capital and allows for ...

  13. Advanced software development workstation: Object-oriented methodologies and applications for flight planning and mission operations

    Science.gov (United States)

    Izygon, Michel

    1993-01-01

    The work accomplished during the past nine months in order to help three different organizations involved in Flight Planning and in Mission Operations systems, to transition to Object-Oriented Technology, by adopting one of the currently most widely used Object-Oriented analysis and Design Methodology is summarized.

  14. Perception-oriented methodology for robust motion estimation design

    NARCIS (Netherlands)

    Heinrich, A.; Vleuten, van der R.J.; Haan, de G.

    2014-01-01

    Optimizing a motion estimator (ME) for picture rate conversion is challenging. This is because there are many types of MEs and, within each type, many parameters, which makes subjective assessment of all the alternatives impractical. To solve this problem, we propose an automatic design methodology

  15. Methodological Orientation of Research Articles Appearing in Higher Education Journals

    Science.gov (United States)

    Ritter, Sherri E.

    2012-01-01

    The purpose of this study was to understand the methodologies authors in higher education journals used to obtain knowledge in their fields. This study looked at five peer reviewed journals of higher education and analyzed the methods of research employed by the authors to help them answer their respective research questions. The methods of…

  16. Comparative analysis as a basic research orientation: Key methodological problems

    Directory of Open Access Journals (Sweden)

    N P Narbut

    2015-12-01

    Full Text Available To date, the Sociological Laboratory of the Peoples’ Friendship University of Russia has accumulated a vast experience in the field of cross-cultural studies reflected in the publications based on the results of mass surveys conducted in Moscow, Maikop, Beijing, Guangzhou, Prague, Belgrade, and Pristina. However, these publications mainly focus on the comparisons of the empirical data rather than methodological and technical issues, that is why the aim of this article is to identify key problems of the comparative analysis in cross-cultural studies that become evident only if you conduct an empirical research yourself - from the first step of setting the problem and approving it by all the sides (countries involved to the last step of interpreting and comparing the data obtained. The authors are sure that no sociologist would ever doubt the necessity and importance of comparative analysis in the broadest sense of the word, but at the same time very few are ready to discuss its key methodological challenges and prefer to ignore them completely. We summarize problems of the comparative analysis in sociology as follows: (1 applying research techniques to the sample in another country - both in translating and adapting them to different social realities and worldview (in particular, the problematic status of standardization and qualitative approach; (2 choosing “right” respondents to question and relevant cases (cultures to study; (3 designing the research scheme, i.e. justifying the sequence of steps (what should go first - methodology or techniques; (4 accepting the procedures that are correct within one country for cross-cultural work (whether or not that is an appropriate choice.

  17. Non-coplanar automatic beam orientation selection in cranial IMRT: a practical methodology

    Energy Technology Data Exchange (ETDEWEB)

    Llacer, Jorge [EC Engineering Consultants LLC, 130 Forest Hill Drive, Los Gatos, CA 95032 (United States); Li Sicong [Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198 (United States); Agazaryan, Nzhde; Solberg, Timothy D [Department of Radiation Oncology, University of California, Los Angeles, CA 90095 (United States); Promberger, Claus [BrainLAB AG, Kapellenstrasse 12, 85622 Feldkirchen (Germany)], E-mail: escalivat@jllacer.com, E-mail: sl1@unmc.edu, E-mail: NAgazaryan@mednet.ucla.edu, E-mail: claus.promberger@brainlab.com, E-mail: Timothy.Solberg@utsouthwestern.edu

    2009-03-07

    This paper proposes a method for automatic selection of beam orientations in non-coplanar cranial IMRT. Methods of computer vision, beam's eye view techniques and neural networks are used to define a new geometry-based methodology that leads to treatment plans for cranial lesions that are comparable in quality to those generated by experienced radiation physicists. The automatic beam selection (ABS) process can be carried out in clinically useful computation times, in 1 min or less for most cases. In the process of describing the ABS process, it is shown that the cranial beam orientation optimization problem is mathematically ill posed, with the expectation that a large number of solutions will lead to similar results. Nevertheless, there are better and worse solutions and we show that the proposed ABS process, by its design, has to lead to one of the better ones. We have carried out extensive tests with 14 patients with beam selection tasks ranging from the rather simple to quite complex. The ABS process has always yielded optimizations with results that are considered good for clinic use. Seven-beam coplanar optimizations for some of the patients have also been investigated. Comparisons with non-coplanar optimizations indicate in which cases the simpler coplanar plans can be used to advantage. Parameters used in the comparisons are dose-volume histograms, minimum and maximum PTV doses, equivalent uniform doses for the PTV and OARs, and treatment volume, conformity and normal tissue indices. It is felt that the current ABS methodology is ready for extensive clinical tests.

  18. Resonance treatment methodology in DeCART

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kang Seog; Joo, Han Gyu; Lee, Chung Chan; Chang, Moon Hee

    2003-12-01

    The typical nuclear design procedure consists of two steps which are the transport lattice calculation for the fuel assembly and the nodal diffusion calculation for the reactor core. DeCART (Deterministic Core Analysis based on Ray Tracing) code has been developed to perform the 3-dimensional whole-core transport calculation removing some of the approximations in the 2-step procedure. This code employs the synthesis of 1- and 2-dimensional characteristics methods in the framework of the 3-dimensional CMFD (Coarse Mesh Finite Difference) formulation. The subgroup method is used for the resonance treatment. HELIOS library is used for the multi-group neutron cross section and the resonance data without any modification. This report includes the methodology of the resonance treatment in DeCART. And this report also includes the Monte Carlo resonance treatment under development for the generation of the resonance integral table and the subgroup data. The interpolation method of the equivalence cross section is reviewed for the efficient resonance transport calculation with thermal-hydraulic feedback, and the new method to consider the temperature distribution explicitly in the subgroup method is also introduced.

  19. A performance-oriented power transformer design methodology using multi-objective evolutionary optimization.

    Science.gov (United States)

    Adly, Amr A; Abd-El-Hafiz, Salwa K

    2015-05-01

    Transformers are regarded as crucial components in power systems. Due to market globalization, power transformer manufacturers are facing an increasingly competitive environment that mandates the adoption of design strategies yielding better performance at lower costs. In this paper, a power transformer design methodology using multi-objective evolutionary optimization is proposed. Using this methodology, which is tailored to be target performance design-oriented, quick rough estimation of transformer design specifics may be inferred. Testing of the suggested approach revealed significant qualitative and quantitative match with measured design and performance values. Details of the proposed methodology as well as sample design results are reported in the paper.

  20. Surreptitious, Evolving and Participative Ontology Development: An End-User Oriented Ontology Development Methodology

    Science.gov (United States)

    Bachore, Zelalem

    2012-01-01

    Ontology not only is considered to be the backbone of the semantic web but also plays a significant role in distributed and heterogeneous information systems. However, ontology still faces limited application and adoption to date. One of the major problems is that prevailing engineering-oriented methodologies for building ontologies do not…

  1. [Perinatal clomiphene citrate treatment changes sexual orientations of male mice].

    Science.gov (United States)

    He, Feng-Qin; Zhang, Heng-Rui

    2013-10-01

    Perinatal period and adolescence are critical for brain development, which is the biological basis of an individual's sexual orientation and sexual behavior. In this study, animals were divided into two groups and their sexual orientations were observed: one group experienced drug treatments during the perinatal period, and the other group was castrated at puberty. The results showed that estradiol treatment had no effect on mature male offspring's sexual orientations, but 9 days and 14 days of clomiphene citrate treatment significantly increased the chance of homosexuality and effeminized behavior. In addition, the sexual orientation of mature normal male offspring, which were castrated when they were 21 days old,was not significant different from the control animals. These findings suggest that the inhibition of perinatal estrogen activities could suppress individual male-typical responses, enhance female-typical responses and induce homosexual orientations. Moreover, the masculinizing effects of estrogen were more obvious during perinatal period than adolescence.

  2. Methodology for object-oriented real-time systems analysis and design: Software engineering

    Science.gov (United States)

    Schoeffler, James D.

    1991-01-01

    Successful application of software engineering methodologies requires an integrated analysis and design life-cycle in which the various phases flow smoothly 'seamlessly' from analysis through design to implementation. Furthermore, different analysis methodologies often lead to different structuring of the system so that the transition from analysis to design may be awkward depending on the design methodology to be used. This is especially important when object-oriented programming is to be used for implementation when the original specification and perhaps high-level design is non-object oriented. Two approaches to real-time systems analysis which can lead to an object-oriented design are contrasted: (1) modeling the system using structured analysis with real-time extensions which emphasizes data and control flows followed by the abstraction of objects where the operations or methods of the objects correspond to processes in the data flow diagrams and then design in terms of these objects; and (2) modeling the system from the beginning as a set of naturally occurring concurrent entities (objects) each having its own time-behavior defined by a set of states and state-transition rules and seamlessly transforming the analysis models into high-level design models. A new concept of a 'real-time systems-analysis object' is introduced and becomes the basic building block of a series of seamlessly-connected models which progress from the object-oriented real-time systems analysis and design system analysis logical models through the physical architectural models and the high-level design stages. The methodology is appropriate to the overall specification including hardware and software modules. In software modules, the systems analysis objects are transformed into software objects.

  3. Methodological Approach to Company Cash Flows Target-Oriented Forecasting Based on Financial Position Analysis

    OpenAIRE

    Sergey Krylov

    2012-01-01

    The article treats a new methodological approach to the company cash flows target-oriented forecasting based on its financial position analysis. The approach is featured to be universal and presumes application of the following techniques developed by the author: financial ratio values correction techniques and correcting cash flows techniques. The financial ratio values correction technique assumes to analyze and forecast company financial position while the correcting cash flows technique i...

  4. MODELS AND METHODS OF SAFETY-ORIENTED PROJECT MANAGEMENT OF DEVELOPMENT OF COMPLEX SYSTEMS: METHODOLOGICAL APPROACH

    Directory of Open Access Journals (Sweden)

    Олег Богданович ЗАЧКО

    2016-03-01

    Full Text Available The methods and models of safety-oriented project management of the development of complex systems are proposed resulting from the convergence of existing approaches in project management in contrast to the mechanism of value-oriented management. A cognitive model of safety oriented project management of the development of complex systems is developed, which provides a synergistic effect that is to move the system from the original (pre condition in an optimal one from the viewpoint of life safety - post-project state. The approach of assessment the project complexity is proposed, which consists in taking into account the seasonal component of a time characteristic of life cycles of complex organizational and technical systems with occupancy. This enabled to take into account the seasonal component in simulation models of life cycle of the product operation in complex organizational and technical system, modeling the critical points of operation of systems with occupancy, which forms a new methodology for safety-oriented management of projects, programs and portfolios of projects with the formalization of the elements of complexity.

  5. Model-driven methodology for rapid deployment of smart spaces based on resource-oriented architectures.

    Science.gov (United States)

    Corredor, Iván; Bernardos, Ana M; Iglesias, Josué; Casar, José R

    2012-01-01

    Advances in electronics nowadays facilitate the design of smart spaces based on physical mash-ups of sensor and actuator devices. At the same time, software paradigms such as Internet of Things (IoT) and Web of Things (WoT) are motivating the creation of technology to support the development and deployment of web-enabled embedded sensor and actuator devices with two major objectives: (i) to integrate sensing and actuating functionalities into everyday objects, and (ii) to easily allow a diversity of devices to plug into the Internet. Currently, developers who are applying this Internet-oriented approach need to have solid understanding about specific platforms and web technologies. In order to alleviate this development process, this research proposes a Resource-Oriented and Ontology-Driven Development (ROOD) methodology based on the Model Driven Architecture (MDA). This methodology aims at enabling the development of smart spaces through a set of modeling tools and semantic technologies that support the definition of the smart space and the automatic generation of code at hardware level. ROOD feasibility is demonstrated by building an adaptive health monitoring service for a Smart Gym.

  6. Model-Driven Methodology for Rapid Deployment of Smart Spaces Based on Resource-Oriented Architectures

    Directory of Open Access Journals (Sweden)

    José R. Casar

    2012-07-01

    Full Text Available Advances in electronics nowadays facilitate the design of smart spaces based on physical mash-ups of sensor and actuator devices. At the same time, software paradigms such as Internet of Things (IoT and Web of Things (WoT are motivating the creation of technology to support the development and deployment of web-enabled embedded sensor and actuator devices with two major objectives: (i to integrate sensing and actuating functionalities into everyday objects, and (ii to easily allow a diversity of devices to plug into the Internet. Currently, developers who are applying this Internet-oriented approach need to have solid understanding about specific platforms and web technologies. In order to alleviate this development process, this research proposes a Resource-Oriented and Ontology-Driven Development (ROOD methodology based on the Model Driven Architecture (MDA. This methodology aims at enabling the development of smart spaces through a set of modeling tools and semantic technologies that support the definition of the smart space and the automatic generation of code at hardware level. ROOD feasibility is demonstrated by building an adaptive health monitoring service for a Smart Gym.

  7. Graphoepitaxy of sexithiophene and orientation control by surface treatment

    International Nuclear Information System (INIS)

    Ikeda, Susumu; Saiki, Koichiro; Wada, Yasuo; Inaba, Katsuhiko; Ito, Yoshiyasu; Kikuchi, Hirokazu; Terashima, Kazuo; Shimada, Toshihiro

    2008-01-01

    The factors influencing the graphoepitaxy of organic semiconductor α-sexithiophene (6T) on thermally oxidized silicon substrates were studied and it was discovered that a wider pitch in the microgrooves decreased the degree of graphoepitaxy. A more significant finding was that in-plane orientation could be changed by simple surface treatment. On UV/ozone-treated substrates (hydrophilic condition), the b-axis of 6T was parallel to the grooves. Further surface treatment with hexamethyl-disiloxane (under hydrophobic conditions) changed this in-plane orientation by 90 deg. This change is due to the interaction between the topmost chemical species (functional groups) of the groove walls and organic molecules, a behavior peculiar to organic graphoepitaxy and exploitable for optimal orientation control in device processing. The nucleation and growth processes that cause the graphoepitaxy are discussed, based on the experimental results

  8. Proposal of a Methodology for Implementing a Service-Oriented Architecture in Distributed Manufacturing Systems

    Science.gov (United States)

    Medina, I.; Garcia-Dominguez, A.; Aguayo, F.; Sevilla, L.; Marcos, M.

    2009-11-01

    As envisioned by Intelligent Manufacturing Systems (IMS), Next Generation Manufacturing Systems (NGMS) will satisfy the needs of an increasingly fast-paced and demanding market by dynamically integrating systems from inside and outside the manufacturing firm itself into a so-called extended enterprise. However, organizing these systems to ensure the maximum flexibility and interoperability with those from other organizations is difficult. Additionally, a defect in the system would have a great impact: it would affect not only its owner, but also its partners. For these reasons, we argue that a service-oriented architecture (SOA) would be a good candidate. It should be designed following a methodology where services play a central role, instead of being an implementation detail. In order for the architecture to be reliable enough as a whole, the methodology will need to help find errors before they arise in a production environment. In this paper we propose using SOA-specific testing techniques, compare some of the existing methodologies and outline several extensions upon one of them to integrate testing techniques.

  9. A methodology to modify land uses in a transit oriented development scenario.

    Science.gov (United States)

    Sahu, Akshay

    2018-05-01

    Developing nations are adopting transit oriented development (TOD) strategies to decongest their transportation systems. These strategies are often adopted after the preparation of land use plans. The goal of this study was to build a methodology to modify these land uses using soft computing. This can help to achieve alternate land use plans relevant to TOD. The methodology incorporates TOD characteristics and objectives. Global TOD parameters (density, diversity, and distance to transit) were studied. Expert opinions gave weights and ranges for the parameters in an Indian TOD scenario. Rules to allocate land use was developed. Objective functions were defined. Four objectives were used. First was to maximize employment density, residential density and percent of mix land use. Second was to shape density and diversity with respect to distance. Third was to minimize degree of land use change, and fourth was to increase compactness of the land use allocation. The methodology was applied to two sectors of Naya Raipur, the new planned administrative capital of the state of Chhattisgarh, India. The city has implemented TOD in the form of Bus rapid transit system (BRTS) over an existing land use. Thousand random plans were generated through the methodology. Top 30 plans were selected as parent population for modifications through genetic algorithm (GA). Alternate plans were generated at the end of GA cycle. The best alternate plan was compared with successful BRTS and TOD land uses for its merits and demerits. It was also compared with the initial land use plan for empirical validation. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Methodology for Plantwide Design and Optimization of Wastewater Treatment Plants

    DEFF Research Database (Denmark)

    Maria Dragan, Johanna; Zubov, Alexandr; Sin, Gürkan

    2017-01-01

    Design of Wastewater Treatment Plants (WWTPs) is a complex engineering task which requires integration of knowledge and experience from environmental biotechnology, process engineering, process synthesis and design as well as mathematical programming. A methodology has been formulated and applied...... for the systematic analysis and development of plantwide design of WWTPs using mathematical optimization and statistical methods such as sensitivity and uncertainty analyses....

  11. Handbook of research on P2P and grid systems for service-oriented computing : models, methodologies, and applications

    NARCIS (Netherlands)

    Antonopoulos, N.; Exarchakos, G.; Li, Maozhen; Liotta, A.

    2010-01-01

    Introduction: Service-oriented computing is a popular design methodology for large scale business computing systems. A significant number of companies aim to reap the benefit of cost reduction by realizing B2B and B2C processes on large-scale SOA-compliant software system platforms. Peer-to-Peer

  12. Creativity, mental disorders and their treatment: recovery-oriented psychopharmacotherapy.

    Science.gov (United States)

    Jakovljević, Miro

    2013-09-01

    This paper discusses interrelations between creativity, mental disorders and their treatment. The psychology of creativity is very important for successful psychopharmacotherapy, but our knowledge about creativity is still insufficient. Even that which is known is not within the armamentarium of most practicing psychiatrists. In the first part of this article creativity and possible associations between creativity, mental health, and well-being are described. The second part deals with the intriguing relationship between creativity and mental disorders. The third part emphasizes the role of creativity in the treatment of mental disorders. This paper ends by underlining the importance of a creativity-enhancing oriented, and personal recovery-focused psychopharmacotherapy in helping psychiatric patients achieve fulfilled and purposeful lives.

  13. [Psychological Treatments for Borderline Personality Disorder: A Review of Cognitive-Behavioral Oriented Therapies].

    Science.gov (United States)

    Marques, Sofia; Barrocas, Daniel; Rijo, Daniel

    2017-04-28

    Borderline personality disorder is the most common personality disorder, with a global prevalence rate between 1.6% and 6%. It is characterized by affective disturbance and impulsivity, which lead to a high number of self-harm behaviors and great amount of health services use. International guidelines recommend psychotherapy as the primary treatment for borderline personality disorder. This paper reviews evidence about the effects and efficacy of cognitive-behavioral oriented psychological treatments for borderline personality disorder. A literature review was conducted in Medline and PubMed databases, using the following keywords: borderline personality disorder, cognitive-behavioral psychotherapy and efficacy. Sixteen randomized clinical trials were evaluate in this review, which analyzed the effects of several cognitive-behavioral oriented psychotherapeutic interventions, namely dialectical behavioral therapy, cognitive behavioral therapy, schema-focused therapy and manual-assisted cognitive therapy. All above stated treatments showed clinical beneficial effects, by reducing borderline personality disorder core pathology and associated general psychopathology, as well as by reducing the severity and frequency of self-harm behaviors, and by improving the overall social, interpersonal and global adjustment. Dialectical behavioral therapy and schema-focused therapy also caused a soaring remission rate of diagnostic borderline personality disorder criteria of 57% and 94%, respectively. Although there were differences between the psychotherapeutic interventions analysed in this review, all showed clinical benefits in the treatment of borderline personality disorder. Dialectical behavioral therapy and schema-focused therapy presented the strongest scientific data documenting their efficacy, but both interventions are integrative cognitive-behavioral therapies which deviate from the traditional cognitive-behavioral model. In summary, the available studies support

  14. Therapist Ethnicity and Treatment Orientation Differences in Multicultural Counseling Competencies

    Science.gov (United States)

    Berger, Lauren K.; Zane, Nolan; Hwang, Wei-Chin

    2014-01-01

    This study examined the relationship between therapist characteristics, therapeutic orientations, person-level and agency-level practices with cultural competency among 221 Los Angeles County community mental health clinicians. Results from an online survey indicated that compared to White therapists, ethnic minority therapists were more personally involved in communities of color, more likely to use a cultural framework in clinical practice, and perceived their agencies to be more culturally sensitive. Ethnic minority therapists also reported greater multicultural (MC) awareness and better MC counseling relationships with their clients than White therapists. Personal involvement in communities of color accounted for ethnic differences in MC awareness and MC counseling relationships. Compared to therapists with a strictly non-behavioral (psychodynamic or humanistic) orientation, therapists with an eclectic (or integrative) therapy orientation reported having a higher level of community knowledge. Therapists with an eclectic orientation reported greater MC awareness than therapists with a non-behavioral orientation, while both eclectic and behavioral (cognitive behavioral or behavior modification) therapists recounted better MC counseling relationships with their clients than therapists with a non-behavioral orientation. Community knowledge mediated eclectic vs. non-behavioral therapeutic orientation differences in MC awareness. Agency resources/linkages and outreach both moderated the relationship between therapeutic orientation and MC skills. Results suggest that if therapists become more personally involved with diverse populations, they will feel more culturally aware and feel like they have a better relationship with ethnic minority clients. PMID:25580187

  15. A Methodological Approach to Encourage the Service-Oriented Learning Systems Development

    Science.gov (United States)

    Diez, David; Malizia, Alessio; Aedo, Ignacio; Diaz, Paloma; Fernandez, Camino; Dodero, Juan-Manuel

    2009-01-01

    The basic idea of service-oriented learning is that a learning environment should be conceived as a set of independent units of learning packaged as learning services. The design, development and deployment of a learning system based on integrating different learning services needs both a technological platform to support the system as well as a…

  16. An Agile Methodology for Implementing Service-Oriented Architecture in Small and Medium Sized Organizations

    Science.gov (United States)

    Laidlaw, Gregory

    2013-01-01

    The purpose of this study is to evaluate the use of Lean/Agile principles, using action research to develop and deploy new technology for Small and Medium sized enterprises. The research case was conducted at the Lapeer County Sheriff's Department and involves the initial deployment of a Service Oriented Architecture to alleviate the data…

  17. Assessing wildlife value orientations in China: an exploration of the concepts and methodology

    Science.gov (United States)

    Sharon Xiangyou Shen; Harry Zinn; Alex Yasong Wang

    2007-01-01

    The wildlife value orientation (WVO) construct has been used to describe deeply-held beliefs about how humans should relate to wildlife. As part of a larger effort to test the usefulness of the WVO construct across cultures, we conducted pilot testing of the construct in China. Sixteen mixed-method interviews were conducted in five cities/towns in China. Participants...

  18. Advanced software development workstation. Comparison of two object-oriented development methodologies

    Science.gov (United States)

    Izygon, Michel E.

    1992-01-01

    This report is an attempt to clarify some of the concerns raised about the OMT method, specifically that OMT is weaker than the Booch method in a few key areas. This interim report specifically addresses the following issues: (1) is OMT object-oriented or only data-driven?; (2) can OMT be used as a front-end to implementation in C++?; (3) the inheritance concept in OMT is in contradiction with the 'pure and real' inheritance concept found in object-oriented (OO) design; (4) low support for software life-cycle issues, for project and risk management; (5) uselessness of functional modeling for the ROSE project; and (6) problems with event-driven and simulation systems. The conclusion of this report is that both Booch's method and Rumbaugh's method are good OO methods, each with strengths and weaknesses in different areas of the development process.

  19. Beyond "on" or "with": Questioning Power Dynamics and Knowledge Production in "Child-Oriented" Research Methodology

    Science.gov (United States)

    Hunleth, Jean

    2011-01-01

    By taking a reflexive approach to research methodology, this article contributes to discussions on power dynamics and knowledge production in the social studies of children. The author describes and analyzes three research methods that she used with children--drawing, child-led tape-recording and focus group discussions. These methods were carried…

  20. Sexual orientation and treatment-seeking for depression in a multilingual worldwide sample.

    Science.gov (United States)

    Rutter, Tara M; Flentje, Annesa; Dilley, James W; Barakat, Suzanne; Liu, Nancy H; Gross, Margaret S; Muñoz, Ricardo F; Leykin, Yan

    2016-12-01

    Prior research has found higher rates of mental health problems among sexual minority individuals. We examine treatment-seeking for depression, as well as its relationship with sexual orientation, in a large, multilingual, international sample. Participants in an automated, quintilingual internet-based depression screening tool were screened for depression, and completed several background measures, including sexual orientation (with an option to decline to state) and past and current depression treatment seeking. 3695 participants screened positive for current or past depression and responded to the sexual orientation question. Those who declined to state their sexual orientation were far less likely to seek any treatment than individuals endorsing any orientation; they were especially unlikely to seek psychotherapy. Individuals identifying as bisexual sought both psychotherapy and alternative treatments at a higher rate than other groups. An interaction was observed between sexual orientation and gender, such that lesbian women were especially likely to have used psychotherapy. Other variables that emerged as significant predictors of treatment-seeking for depression included age and participant's language. Limitations include possible misinterpretation of translated terms due to regional differences, and possible limits to generalizability due to this study being conducted on the internet. Our results suggest that individuals who decline to state their sexual orientation may be more likely to forgo effective treatments for depression. Further studies of depression service utilization should focus on developing treatment modalities that could better engage sexual minority individuals, especially those who are reluctant to disclose their orientation. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. Applications of an OO (Objected Oriented) methodology and case to a DAQ system

    International Nuclear Information System (INIS)

    Bee, C.P.; Eshghi, S.; Jones, R.

    1996-01-01

    The RD13 project has evaluated the use of the Object Oriented Information Engineering (OOIE) method during the development of several software components connected to the DAQ system. The method is supported by a sophisticated commercial CASE tool (Object Management Workbench) and programming environment (Kappa) which covers the full life-cycle of the software including model simulation, code generation and application deployment. This paper gives an overview of the method, CASE tool, DAD components which have been developed and we relate our experiences with the method and tool, its integration into our development environment and the spiral life cycle if supports. (author)

  2. Agent-oriented software engineering reflections on architectures, methodologies, languages, and frameworks

    CERN Document Server

    Shehory, Onn

    2014-01-01

    With this book, Onn Shehory and Arnon Sturm, together with further contributors, introduce the reader to various facets of agent-oriented software engineering (AOSE). They provide a selected collection of state-of-the-art findings, which combines research from information systems, artificial intelligence, distributed systems and software engineering and covers essential development aspects of agent-based systems. The book chapters are organized into five parts. The first part introduces the AOSE domain in general, including introduction to agents and the peculiarities of software engineerin

  3. An ultrasonic methodology to non-destructively estimate the grain orientation in an anisotropic weld

    Directory of Open Access Journals (Sweden)

    Wirdelius Håkan

    2014-06-01

    Full Text Available The initial step towards a non-destructive technique that estimates grain orientation in an anisotropic weld is presented in this paper. The purpose is to aid future forward simulations of ultrasonic NDT of this kind of weld to achieve a better result. A forward model that consists of a weld model, a transmitter model, a receiver model and a 2D ray tracing algorithm is introduced. An inversion based on a multi-objective genetic algorithm is also presented. Experiments are conducted for both P and SV waves in order to collect enough data used in the inversion. Calculation is conducted to fulfil the estimation with both the synthetic data and the experimental data. Concluding remarks are presented at the end of the paper.

  4. Methodology for Developing a Diesel Exhaust After Treatment Simulation Tool

    DEFF Research Database (Denmark)

    Christiansen, Tine; Jensen, Johanne; Åberg, Andreas

    2018-01-01

    A methodology for the development of catalyst models is presented. Also, a methodology of the implementation of such models into a modular simulation tool, which simulates the units in succession, is presented. A case study is presented illustrating how suitable models can be found and used for s...

  5. Case Study of Oriental Medicine Treatment with acupotomy Therpy of the Tarsal tunnel Syndrome

    Directory of Open Access Journals (Sweden)

    Lim Na-ra

    2009-03-01

    Full Text Available Purpose : In order to estimate clinical effects of Oriental Medicine Treatment with acupotomy therapy of Tarsal tunnel Syndrome Methods : From 5th November, 2008 to 8th November, 2008, 1 male patient diagnosed as Tarsal tunnel syndrome(clinical diagnosed was treated with general oriental medicine therapy (acupuncture, moxibustion, cupping, physical therapy, herbal medication and acupotomy. Results : The patient's Rt foot paresthesia, pain were remarkably improved. Conclusions : This study demonstrates that oriental medical treatment with acuputomy therapy has notable effect in improving symptoms of tarsal tunnel syndrome. as though we had not wide experience in this treatment, more research is needed.

  6. BPLOM: BPM Level-Oriented Methodology for Incremental Business Process Modeling and Code Generation on Mobile Platforms

    Directory of Open Access Journals (Sweden)

    Jaime Solis Martines

    2013-06-01

    Full Text Available The requirements engineering phase is the departure point for the development process of any kind of computer application, it determines the functionality needed in the working scenario of the program. Although this is a crucial point in application development, as incorrect requirement definition leads to costly error appearance in later stages of the development process, application domain experts’ implication remains minor. In order to correct this scenario, business process modeling notations were introduced to favor business expert implication in this phase, but notation complexity prevents this participation to reach its ideal state. Hence, we promote the definition of a level oriented business process methodology, which encourages the adaptation of the modeling notation to the modeling and technical knowledge shown by the expert. This approach reduces the complexity found by domain experts and enables them to model their processes completely with a level of technical detail directly proportional to their knowledge.

  7. Metacognition-oriented social skills training for individuals with long-term schizophrenia: methodology and clinical illustration.

    Science.gov (United States)

    Ottavi, Paolo; D'Alia, Daria; Lysaker, Paul; Kent, Jerillyn; Popolo, Raffaele; Salvatore, Giampaolo; Dimaggio, Giancarlo

    2014-01-01

    There is much evidence indicating the presence of social deficits in schizophrenia and the detrimental effect of these deficits on global functioning in this population. As a result, social skills training (SST) has emerged as a legitimate psychosocial treatment, although effectiveness research has revealed small effect sizes and limited generalizability regarding the benefits of this treatment. In light of the strong evidence of metacognitive deficits in schizophrenia and the importance of metacognition to successful social functioning, we propose a novel therapeutic intervention wherein metacognitive remediation is integrated into SST: metacognition-oriented social skills training (MOSST). In the current paper, we present MOSST, an adapted SST programme wherein clients are also encouraged to have mindful contact with their own thoughts and to better consider and understand the mental states of others as well as the connection between mental states and behaviour. We present a case wherein an individual with schizophrenia successfully completed the MOSST programme. We outline directions for future research, starting with the logical next step of empirically testing the efficacy of MOSST. Currently social skills training is considered to be the elected psychosocial treatment for people affected by schizophrenia, although evidence indicates limited benefits. People with schizophrenia have metacognitive deficits, which interfere with proper social functioning. A metacognitive-oriented social skills training (MOSST) intervention has been developed by the authors.A treatment such as MOSST, which integrates social skills training and metacognitive training, promises to improve social skills through improving the metacognition. Copyright © 2013 John Wiley & Sons, Ltd.

  8. A flexible hydrological modelling system developed using an object oriented methodology

    Energy Technology Data Exchange (ETDEWEB)

    Rinde, Trond

    1998-12-31

    The report presents a software system called Process Integrating Network (PINE). The capabilities, working principles, programming technical design and principles of use of the system are described as are some practical applications. PINE is a simulation tool for modelling of hydrological and hydrologically related phenomena. The system is based on object oriented programming principles and was specially designed to provide freedom in the choice of model structures and algorithms for process descriptions. It supports full freedom with regards to spatial distribution and temporal resolution. Geographical information systems (GIS) may be integrated with PINE in order to provide full spatial distribution in system parametrisation, process simulation and visualisation of simulation results. Simulation models are developed by linking components for process description together in a structure. The system can handle compound working media such as water with chemical or biological constituents. Non-hydrological routines may then be included to describe the responses of such constituents. Features such as extensibility and reuse of program components are emphasised in the program design. Separation between process topology, process descriptions and process data facilitates simple and consistent implementation of components for process description. Such components may be automatically prototyped and their response functions may be implemented without knowledge of other parts of the program system and without the need to program import or export routines or a user interface. Model extension is thus a rapid process that does not require extensive programming skills. Components for process descriptions may further be placed in separate program libraries, which can be included in the program as required. The program system can thus be very compact while it still has a large number of process algorithms available. The system can run on both PC and UNIX platforms. 106 figs., 20

  9. An alternative methodology for the mathematical treatment of GPS positioning

    Directory of Open Access Journals (Sweden)

    Aly M. El-naggar

    2011-12-01

    In this paper a simple alternative method is developed to solve the GPS navigation equations directly without linearization and iteration. A practical study was done to evaluate the new model. Performance analysis was conducted using data collected by Trimble 4000SSE dual frequency receiver. The results indicated that the alternative methodology is simple, fast, and accurate as compared to Taylor method.

  10. Statistical methodology for discrete fracture model - including fracture size, orientation uncertainty together with intensity uncertainty and variability

    International Nuclear Information System (INIS)

    Darcel, C.; Davy, P.; Le Goc, R.; Dreuzy, J.R. de; Bour, O.

    2009-11-01

    the other, addresses the issue of the nature of the transition. We develop a new 'mechanistic' model that could help in modeling why and where this transition can occur. The transition between both regimes would occur for a fracture length of 1-10 m and even at a smaller scale for the few outcrops that follow the self-similar density model. A consequence for the disposal issue is that the model that is likely to apply in the 'blind' scale window between 10-100 m is the self-similar model as it is defined for large-scale lineaments. The self-similar model, as it is measured for some outcrops and most lineament maps, is definitely worth being investigated as a reference for scales above 1-10 m. In the rest of the report, we develop a methodology for incorporating uncertainty and variability into the DFN modeling. Fracturing properties arise from complex processes which produce an intrinsic variability; characterizing this variability as an admissible variation of model parameter or as the division of the site into subdomains with distinct DFN models is a critical point of the modeling effort. Moreover, the DFN model encompasses a part of uncertainty, due to data inherent uncertainties and sampling limits. Both effects must be quantified and incorporated into the DFN site model definition process. In that context, all available borehole data including recording of fracture intercept positions, pole orientation and relative uncertainties are used as the basis for the methodological development and further site model assessment. An elementary dataset contains a set of discrete fracture intercepts from which a parent orientation/density distribution can be computed. The elementary bricks of the site, from which these initial parent density distributions are computed, rely on the former Single Hole Interpretation division of the boreholes into sections whose local boundaries are expected to reflect - locally - geology and fracturing properties main characteristics. From that

  11. Enzyme and methodology for the treatment of a biomass

    Science.gov (United States)

    Thompson, Vicki S.; Thompson, David N.; Schaller, Kastli D.; Apel, William A.

    2010-06-01

    An enzyme isolated from an extremophilic microbe, and a method for utilizing same is described, and wherein the enzyme displays optimum enzymatic activity at a temperature of greater than about 80.degree. C., and a pH of less than about 2, and further may be useful in methodology including pretreatment of a biomass so as to facilitate the production of an end product.

  12. Towards biology-oriented treatment planning in hadrontherapy

    Czech Academy of Sciences Publication Activity Database

    Kundrát, Pavel

    2006-01-01

    Roč. 122, 1-4 (2006), s. 480-482 ISSN 0144-8420 R&D Projects: GA ČR GA202/05/2728 Institutional research plan: CEZ:AV0Z10100502 Keywords : treatment planning * hadron radiotherapy Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 0.446, year: 2006

  13. Analysis and design of the SI-simulator software system for the VHTR-SI process by using the object-oriented analysis and object-oriented design methodology

    International Nuclear Information System (INIS)

    Chang, Jiwoon; Shin, Youngjoon; Kim, Jihwan; Lee, Kiyoung; Lee, Wonjae; Chang, Jonghwa; Youn, Cheung

    2008-01-01

    The SI-simulator is an application software system that simulates the dynamic behavior of the VHTR-SI process by the use of mathematical models. Object-oriented analysis (OOA) and object-oriented design (OOD) methodologies were employed for the SI simulator system development. OOA is concerned with developing software engineering requirements and specifications that are expressed as a system's object model (which is composed of a population of interacting objects), as opposed to the traditional data or functional views of systems. OOD techniques are useful for the development of large complex systems. Also, OOA/OOD methodology is usually employed to maximize the reusability and extensibility of a software system. In this paper, we present a design feature for the SI simulator software system by the using methodologies of OOA and OOD

  14. Applying TOGAF for e-government implementation based on service oriented architecture methodology towards good government governance

    Science.gov (United States)

    Hodijah, A.; Sundari, S.; Nugraha, A. C.

    2018-05-01

    As a Local Government Agencies who perform public services, General Government Office already has utilized Reporting Information System of Local Government Implementation (E-LPPD). However, E-LPPD has upgrade limitation for the integration processes that cannot accommodate General Government Offices’ needs in order to achieve Good Government Governance (GGG), while success stories of the ultimate goal of e-government implementation requires good governance practices. Currently, citizen demand public services as private sector do, which needs service innovation by utilizing the legacy system as a service based e-government implementation, while Service Oriented Architecture (SOA) to redefine a business processes as a set of IT enabled services and Enterprise Architecture from the Open Group Architecture Framework (TOGAF) as a comprehensive approach in redefining business processes as service innovation towards GGG. This paper takes a case study on Performance Evaluation of Local Government Implementation (EKPPD) system on General Government Office. The results show that TOGAF will guide the development of integrated business processes of EKPPD system that fits good governance practices to attain GGG with SOA methodology as technical approach.

  15. Methodology for Designing Models Predicting Success of Infertility Treatment

    OpenAIRE

    Alireza Zarinara; Mohammad Mahdi Akhondi; Hojjat Zeraati; Koorsh Kamali; Kazem Mohammad

    2016-01-01

    Abstract Background: The prediction models for infertility treatment success have presented since 25 years ago. There are scientific principles for designing and applying the prediction models that is also used to predict the success rate of infertility treatment. The purpose of this study is to provide basic principles for designing the model to predic infertility treatment success. Materials and Methods: In this paper, the principles for developing predictive models are explained and...

  16. A research-oriented treatment planning program system

    International Nuclear Information System (INIS)

    Kalet, I.J.; Jacky, J.P.

    1982-01-01

    The function of a treatment planning program is to graphically simulate radiation dose distributions from proposed radiation therapy treatments. While many such programs are available which provide this much-needed service, none addresses the question of how to intercompare calculation and display techniques. This paper describes a program system designed for support of research efforts, particularly development and testing of new calculation algorithms. The system emphasizes a modular flexible structure, enabling programs to be developed somewhat as interchangeable parts. Thus multiple variants of a calculation algorithm can be compared without undue software overhead or additional data management. Unusual features of the system include extensive use of command procedures, logical names and a structured language (PASCAL). These features are described along with other implementation details. Obstacles, limitations and future applications are also discussed. (Auth.)

  17. SMITHERS: An object-oriented modular mapping methodology for MCNP-based neutronic–thermal hydraulic multiphysics

    International Nuclear Information System (INIS)

    Richard, Joshua; Galloway, Jack; Fensin, Michael; Trellue, Holly

    2015-01-01

    Highlights: • A modular mapping methodogy for neutronic-thermal hydraulic nuclear reactor multiphysics, SMITHERS, has been developed. • Written in Python, SMITHERS takes a novel object-oriented approach for facilitating data transitions between solvers. This approach enables near-instant compatibility with existing MCNP/MONTEBURNS input decks. • It also allows for coupling with thermal-hydraulic solvers of various levels of fidelity. • Two BWR and PWR test problems are presented for verifying correct functionality of the SMITHERS code routines. - Abstract: A novel object-oriented modular mapping methodology for externally coupled neutronics–thermal hydraulics multiphysics simulations was developed. The Simulator using MCNP with Integrated Thermal-Hydraulics for Exploratory Reactor Studies (SMITHERS) code performs on-the-fly mapping of material-wise power distribution tallies implemented by MCNP-based neutron transport/depletion solvers for use in estimating coolant temperature and density distributions with a separate thermal-hydraulic solver. The key development of SMITHERS is that it reconstructs the hierarchical geometry structure of the material-wise power generation tallies from the depletion solver automatically, with only a modicum of additional information required from the user. Additionally, it performs the basis mapping from the combinatorial geometry of the depletion solver to the required geometry of the thermal-hydraulic solver in a generalizable manner, such that it can transparently accommodate varying levels of thermal-hydraulic solver geometric fidelity, from the nodal geometry of multi-channel analysis solvers to the pin-cell level of discretization for sub-channel analysis solvers. The mapping methodology was specifically developed to be flexible enough such that it could successfully integrate preexisting depletion solver case files with different thermal-hydraulic solvers. This approach allows the user to tailor the selection of a

  18. Identification of new treatments for epilepsy: issues in preclinical methodology

    Science.gov (United States)

    Galanopoulou, Aristea S.; Buckmaster, Paul S.; Staley, Kevin J.; Moshé, Solomon L.; Perucca, Emilio; Engel, Jerome; Löscher, Wolfgang; Noebels, Jeffrey L.; Pitkänen, Asla; Stables, James; White, Steve H.; O’Brien, Terence J.; Simonato, Michele

    2013-01-01

    Summary Preclinical research has facilitated the discovery of valuable drugs for the symptomatic treatment of epilepsy. Yet, despite these therapies, seizures are not adequately controlled in a third of all affected individuals, and comorbidities still impose a major burden on quality of life. The introduction of multiple new therapies into clinical use over the past two decades has done little to change this. There is an urgent demand to address the unmet clinical needs for: (a) new symptomatic anti-seizure treatments for drug-resistant seizures with improved efficacy/tolerability profiles, (b) disease modifying treatments that prevent or ameliorate the epileptogenic state, and (c) treatments for the common comorbidities that contribute to disability in people with epilepsy. New therapies also need to address the special needs of certain subpopulations, i.e. age- or gender-specific treatments. Preclinical development in these treatment areas is complex due to heterogeneity in presentation and etiology, and may need to be formulated with a specific seizure, epilepsy syndrome or comorbidity in mind. The aim of this report is to provide a framework that will help define future guidelines that improve and standardize the design, reporting, and validation of data across preclinical anti-epilepsy therapy development studies targeting drug-resistant seizures, epileptogenesis and comorbidities. PMID:22292566

  19. Identification of new epilepsy treatments: issues in preclinical methodology.

    Science.gov (United States)

    Galanopoulou, Aristea S; Buckmaster, Paul S; Staley, Kevin J; Moshé, Solomon L; Perucca, Emilio; Engel, Jerome; Löscher, Wolfgang; Noebels, Jeffrey L; Pitkänen, Asla; Stables, James; White, H Steve; O'Brien, Terence J; Simonato, Michele

    2012-03-01

    Preclinical research has facilitated the discovery of valuable drugs for the symptomatic treatment of epilepsy. Yet, despite these therapies, seizures are not adequately controlled in a third of all affected individuals, and comorbidities still impose a major burden on quality of life. The introduction of multiple new therapies into clinical use over the past two decades has done little to change this. There is an urgent demand to address the unmet clinical needs for: (1) new symptomatic antiseizure treatments for drug-resistant seizures with improved efficacy/tolerability profiles, (2) disease-modifying treatments that prevent or ameliorate the process of epileptogenesis, and (3) treatments for the common comorbidities that contribute to disability in people with epilepsy. New therapies also need to address the special needs of certain subpopulations, that is, age- or gender-specific treatments. Preclinical development in these treatment areas is complex due to heterogeneity in presentation and etiology, and may need to be formulated with a specific seizure, epilepsy syndrome, or comorbidity in mind. The aim of this report is to provide a framework that will help define future guidelines that improve and standardize the design, reporting, and validation of data across preclinical antiepilepsy therapy development studies targeting drug-resistant seizures, epileptogenesis, and comorbidities. Wiley Periodicals, Inc. © 2012 International League Against Epilepsy.

  20. Case Study of Oriental Medicine Treatment with acupotomy Therapy of the Achilles Tendinitis

    Directory of Open Access Journals (Sweden)

    Jang Eun-ha

    2008-12-01

    Full Text Available Purpose : In order to estimate clinical effects of Oriental Medicine Treatment with acupotomy therapy of Achilles Tendinitis Methods : From 4th August, 2008 to 14th August, 2008, 1 female patient diagnosed as Chronic Achilles Tendinitis (clinical diagnosed was treated with general oriental medicine therapy(acupuncture, moxibustion, cupping, physical therapy, herbal medication and acupotomy. Results : The patient's chief complaints- Lt. heel pain and stiffness, dorsi-flexion limitation, nodules in the achilles tendon- were notably improved. Conclusions : This study demonstrates that oriental medical treatment with acuputomy therapy has significant effect in improving symptoms of achilles tendinitis. as though we had not wide experience in this treatment, more research is needed.

  1. Methodological treatment to the process of appreciation of the local architecture

    Directory of Open Access Journals (Sweden)

    Eida Aguiar Hernández

    2015-03-01

    Full Text Available In the article it is deepened about different methodological conceptions on the appreciation, particularly in architecture. It is given methodological treatment to the process of appreciation of this manifestation in the town like testimony of a certain time of the society, for that reason it is essential the appreciation of the most authentic values in the local art.

  2. A systematic methodology for controller tuning in wastewater treatment plants

    DEFF Research Database (Denmark)

    Mauricio Iglesias, Miguel; Jørgensen, S.B.; Sin, G.

    2012-01-01

    Wastewater treatment plants are typically subject to continuous disturbances caused by influent variations which exhibits diurnal patterns as well as stochastic changes due to rain and storm water events. In order to achieve an efficient operation, the control system of the plant should be able t...

  3. Statistical methodology for discrete fracture model - including fracture size, orientation uncertainty together with intensity uncertainty and variability

    Energy Technology Data Exchange (ETDEWEB)

    Darcel, C. (Itasca Consultants SAS (France)); Davy, P.; Le Goc, R.; Dreuzy, J.R. de; Bour, O. (Geosciences Rennes, UMR 6118 CNRS, Univ. def Rennes, Rennes (France))

    2009-11-15

    the lineament scale (k{sub t} = 2) on the other, addresses the issue of the nature of the transition. We develop a new 'mechanistic' model that could help in modeling why and where this transition can occur. The transition between both regimes would occur for a fracture length of 1-10 m and even at a smaller scale for the few outcrops that follow the self-similar density model. A consequence for the disposal issue is that the model that is likely to apply in the 'blind' scale window between 10-100 m is the self-similar model as it is defined for large-scale lineaments. The self-similar model, as it is measured for some outcrops and most lineament maps, is definitely worth being investigated as a reference for scales above 1-10 m. In the rest of the report, we develop a methodology for incorporating uncertainty and variability into the DFN modeling. Fracturing properties arise from complex processes which produce an intrinsic variability; characterizing this variability as an admissible variation of model parameter or as the division of the site into subdomains with distinct DFN models is a critical point of the modeling effort. Moreover, the DFN model encompasses a part of uncertainty, due to data inherent uncertainties and sampling limits. Both effects must be quantified and incorporated into the DFN site model definition process. In that context, all available borehole data including recording of fracture intercept positions, pole orientation and relative uncertainties are used as the basis for the methodological development and further site model assessment. An elementary dataset contains a set of discrete fracture intercepts from which a parent orientation/density distribution can be computed. The elementary bricks of the site, from which these initial parent density distributions are computed, rely on the former Single Hole Interpretation division of the boreholes into sections whose local boundaries are expected to reflect - locally - geology

  4. A methodological pilot: parenting among women in substance abuse treatment.

    Science.gov (United States)

    Lewin, Linda; Farkas, Kathleen; Niazi, Maryam

    2014-01-01

    Mothers who abuse substances are likely to have insecure emotional attachment with their children, placing their children at risk for social-emotional and psychiatric conditions. Sobriety does not inevitably improve parenting. We tested recruitment methods, audiovisual (AV) recording procedures, the protocol for identifying child abuse risk, the coding of mother-child interactions, and retention of the sample for repeated measures as the first phase in examining mother-child relational quality of women in substance abuse treatment. This innovative study involved AV recordings to capture the in-vivo mother-child interactional behaviors that were later coded and analyzed for mean scores on the 64-item Parent-Child Relational Quality Assessment. Repeated measurement was planned during treatment and two months after discharge from treatment. The pilot involved a small sample (n = 11) of mother-child (interaction behaviors were identified. Mothers showed less enthusiasm and creativity but matched their child's emotional state. The children showed appropriate motor skill items and attachment behaviors. The dyad coding showed less mutual enjoyment between the mother and child. Eight of the participants could not be located for the second measurement despite multiple contact methods. AV recordings capture rich, descriptive information that can be coded for interactional quality analysis. Repeated measurement with this cohort was not feasible, thus needing to assess for additional/more frequent contacts to maintain the sample.

  5. Environmental assessment of digestate treatment technologies using LCA methodology.

    Science.gov (United States)

    Vázquez-Rowe, Ian; Golkowska, Katarzyna; Lebuf, Viooltje; Vaneeckhaute, Céline; Michels, Evi; Meers, Erik; Benetto, Enrico; Koster, Daniel

    2015-09-01

    The production of biogas from energy crops, organic waste and manure has augmented considerably the amounts of digestate available in Flanders. This has pushed authorities to steadily introduce legislative changes to promote its use as a fertilising agent. There is limited arable land in Flanders, which entails that digestate has to compete with animal manure to be spread. This forces many anaerobic digestion plants to further treat digestate in such a way that it can either be exported or the nitrogen be removed. Nevertheless, the environmental impact of these treatment options is still widely unknown, as well as the influence of these impacts on the sustainability of Flemish anaerobic digestion plants in comparison to other regions where spreading of raw digestate is allowed. Despite important economic aspects that must be considered, the use of Life Cycle Assessment (LCA) is suggested in this study to identify the environmental impacts of spreading digestate directly as compared to four different treatment technologies. Results suggest relevant environmental gains when the digestate mix is treated using the examined conversion technologies prior to spreading, although important trade-offs between impact categories were observed and discussed. The promising results of digestate conversion technologies suggest that further LCA analyses should be performed to delve into, for instance, the appropriateness to shift to nutrient recovery technologies rather than digestate conversion treatments. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. Young children and obesity : development and evaluation of familiy-oriented treatment

    NARCIS (Netherlands)

    Hoek, van E.

    2015-01-01

    Thesis: Young Children and Obesity – Development and Evaluation of Family-oriented Treatment, Esther van Hoek

    Introduction

    The prevalence of childhood obesity has increased rapidly during the last decades. Childhood obesity is a multisystem disease with serious consequences such as

  7. Orienting Block Copolymer Thin Films via Entropy and Surface Plasma Treatment

    Science.gov (United States)

    Ho, Rong-Ming; Lu, Kai-Yuan; Lo, Ting-Ya; Dehghan, Ashkan; Shi, An-Chang; Prokopios, Georgopanos; Avgeropoulos, Apostolos

    Controlling the orientation of nanostructured thin films of block copolymers (BCPs) is essential for next generation lithography. In the thin-film state, how to achieve the perpendicular orientation of the nanostructured microdomains remains challenging due to the interfacial effects from the air and also the substrate, especially for the blocks with silicon containing segments which usually have different surface energies, favoring parallel microdomain orientation. Here, we show that entropic effect can be used to control the orientation of BCP thin films. Specifically, we used the architecture of star-block copolymers consisting of polystyrene (PS) and poly(dimethylsiloxane) (PDMS) blocks to regulate the entropic contribution to the self-assembled nanostructures. Moreover, we aim to achieve the formation of perpendicular orientation from the air surface via surface plasma treatment to neutralize the interfacial energy difference. By combining the architecture effect (entropy effect) on BCP self-assembly and the surface plasma treatment (enthalpy effect), well-defined perpendicular PDMS microdomains in the PS-b-PDMS thin film can be formed from the bottom of non-neutral substrate and the top of the thin film surface, giving great potential for lithographic applications.

  8. METHODOLOGY OF PROSTHETIC TREATMENT IN PATIENTS WITH MAXILLECTOMY

    Directory of Open Access Journals (Sweden)

    Ivan Gerdzhikov

    2018-06-01

    Full Text Available Aim: The aim of the described method is to present the main stages in the prosthetic treatment with hollow bulb obturator, which provides optimum defect hermetization and restoration of the damaged functions. Materials and methods: The clinical case, described is on a 70-years-old patient with edentulous jaws and maxillary defect in the right half of the upper jaw. The preliminary impressions were taken with irreversible hydrocolloid impression material, and the final impressions were taken with additive silicone material. The occlusion height and the centric relations were registered as the classical technique. After the successful trial denture appointment, the surface of the plaster master model was covered by isolation polish. After this procedure, the master model was covered by even wax layer with 5mm thickness. It was designed to be thinner in the area of the resection line. The designed cavity was filled in with silicone impression material and covered with the folio. The base plate with the arranged teeth was fixed to the model, packed in the cuvette and finished from heat-cured acrylic resin with low quantity of residual monomer. After the polymerization process, the silicone material was removed, and the obturators cap was fixed to the denture’s base plate with cold cured acrylic resin. The obturator and the complete denture of the mandible were adjusted and articulated in patient’s mouth in the final clinical stage. Results: The applied prosthetic method allowed successful defect hermetization and helped for the restoration of the speech, feeding and patient’s self-esteem. Conclusion: Prosthetic rehabilitation of patients with maxillary resection is possible only with the application of specific treatment methods.

  9. SU-E-J-15: Automatically Detect Patient Treatment Position and Orientation in KV Portal Images

    Energy Technology Data Exchange (ETDEWEB)

    Qiu, J [Washington University in St Louis, Taian, Shandong (China); Yang, D [Washington University School of Medicine, St Louis, MO (United States)

    2015-06-15

    Purpose: In the course of radiation therapy, the complex information processing workflow will Result in potential errors, such as incorrect or inaccurate patient setups. With automatic image check and patient identification, such errors could be effectively reduced. For this purpose, we developed a simple and rapid image processing method, to automatically detect the patient position and orientation in 2D portal images, so to allow automatic check of positions and orientations for patient daily RT treatments. Methods: Based on the principle of portal image formation, a set of whole body DRR images were reconstructed from multiple whole body CT volume datasets, and fused together to be used as the matching template. To identify the patient setup position and orientation shown in a 2D portal image, the 2D portal image was preprocessed (contrast enhancement, down-sampling and couch table detection), then matched to the template image so to identify the laterality (left or right), position, orientation and treatment site. Results: Five day’s clinical qualified portal images were gathered randomly, then were processed by the automatic detection and matching method without any additional information. The detection results were visually checked by physicists. 182 images were correct detection in a total of 200kV portal images. The correct rate was 91%. Conclusion: The proposed method can detect patient setup and orientation quickly and automatically. It only requires the image intensity information in KV portal images. This method can be useful in the framework of Electronic Chart Check (ECCK) to reduce the potential errors in workflow of radiation therapy and so to improve patient safety. In addition, the auto-detection results, as the patient treatment site position and patient orientation, could be useful to guide the sequential image processing procedures, e.g. verification of patient daily setup accuracy. This work was partially supported by research grant from

  10. SU-E-J-15: Automatically Detect Patient Treatment Position and Orientation in KV Portal Images

    International Nuclear Information System (INIS)

    Qiu, J; Yang, D

    2015-01-01

    Purpose: In the course of radiation therapy, the complex information processing workflow will Result in potential errors, such as incorrect or inaccurate patient setups. With automatic image check and patient identification, such errors could be effectively reduced. For this purpose, we developed a simple and rapid image processing method, to automatically detect the patient position and orientation in 2D portal images, so to allow automatic check of positions and orientations for patient daily RT treatments. Methods: Based on the principle of portal image formation, a set of whole body DRR images were reconstructed from multiple whole body CT volume datasets, and fused together to be used as the matching template. To identify the patient setup position and orientation shown in a 2D portal image, the 2D portal image was preprocessed (contrast enhancement, down-sampling and couch table detection), then matched to the template image so to identify the laterality (left or right), position, orientation and treatment site. Results: Five day’s clinical qualified portal images were gathered randomly, then were processed by the automatic detection and matching method without any additional information. The detection results were visually checked by physicists. 182 images were correct detection in a total of 200kV portal images. The correct rate was 91%. Conclusion: The proposed method can detect patient setup and orientation quickly and automatically. It only requires the image intensity information in KV portal images. This method can be useful in the framework of Electronic Chart Check (ECCK) to reduce the potential errors in workflow of radiation therapy and so to improve patient safety. In addition, the auto-detection results, as the patient treatment site position and patient orientation, could be useful to guide the sequential image processing procedures, e.g. verification of patient daily setup accuracy. This work was partially supported by research grant from

  11. Psychological Treatments for Borderline Personality Disorder: A Review of Cognitive-Behavioral Oriented Therapies

    Directory of Open Access Journals (Sweden)

    Sofia Marques

    2017-04-01

    Conclusion: In summary, the available studies support cognitive-behavioral psychological treatments as an efficacious intervention in borderline personality disorder. However, the existing scientific literature on this topic is still scarce and there is need for more studies, with higher methodological rigor, that should validate these results.

  12. Management strategy for patients with gastroesophageal reflux disease: a comparison between empirical treatment with esomeprazole and endoscopy-oriented treatment.

    Science.gov (United States)

    Giannini, Edoardo G; Zentilin, Patrizia; Dulbecco, Pietro; Vigneri, Sergio; Scarlata, Pamela; Savarino, Vincenzo

    2008-02-01

    Whether patients with typical gastroesophageal reflux disease (GERD) symptoms and without alarm features should be treated empirically or undergo endoscopy first is a debated issue. In this study, our aim was to assess the efficacy, and to compare the direct costs and impact on health-related quality of life (HRQL), of two treatment strategies (empirical vs endoscopy-oriented treatment) in a large population of patients with GERD. In total, 612 patients were randomized to either empirical treatment with esomeprazole 40 mg once daily (od) (group 1, N = 309) or endoscopy and treatment according to endoscopic findings (group 2, N = 303, esomeprazole 40 mg od in patients with reflux esophagitis and esomeprazole 20 mg od in patients without esophagitis) for 4 wk, followed by esomeprazole 20 mg od maintenance treatment in both groups. Direct costs and HRQL were analyzed in both treatment arms. At the end of the acute treatment phase (week 4), 267 patients in group 1 (86.4%) and 265 patients in group 2 (87.5%) were considered responders to treatment (intention-to-treat analysis, P= 0.878). Empirical treatment proved to be cost-effective by saving 38.72 euros per treated patient. At the end of the maintenance phase (week 24), a similar proportion of patients responded to treatment in the two groups (71.8%vs 68.3%, P= 0.389). HRQL improved from baseline to week 24 in both groups (difference between study groups not significant). In patients with GERD, empirical treatment with esomeprazole proved to be cost-effective compared with endoscopy-oriented treatment, and did not negatively affect patient HRQL. These results should be taken into account in the management of GERD patients in clinical practice.

  13. On the use of response surface methodology to predict and interpret the preferred c-axis orientation of sputtered AlN thin films

    International Nuclear Information System (INIS)

    Adamczyk, J.; Horny, N.; Tricoteaux, A.; Jouan, P.-Y.; Zadam, M.

    2008-01-01

    This paper deals with experimental design applied to response surface methodology (RSM) in order to determine the influence of the discharge conditions on preferred c-axis orientation of sputtered AlN thin films. The thin films have been deposited by DC reactive magnetron sputtering on Si (1 0 0) substrates. The preferred orientation was evaluated using a conventional Bragg-Brentano X-ray diffractometer (θ-2θ) with the CuKα radiation. We have first determined the experimental domain for 3 parameters: sputtering pressure (2-6 mTorr), discharge current (312-438 mA) and nitrogen percentage (17-33%). For the setup of the experimental design we have used a three factors Doehlert matrix which allows the use of the statistical response surface methodology (RSM) in a spherical domain. A four dimensional surface response, which represents the (0 0 0 2) peak height as a function of sputtering pressure, discharge current and nitrogen percentage, was obtained. It has been found that the main interaction affecting the preferential c-axis orientation was the pressure-nitrogen percentage interaction. It has been proved that a Box-Cox transformation is a very useful method to interpret and discuss the experimental results and leads to predictions in good agreement with experiments

  14. On the use of response surface methodology to predict and interpret the preferred c-axis orientation of sputtered AlN thin films

    Energy Technology Data Exchange (ETDEWEB)

    Adamczyk, J.; Horny, N.; Tricoteaux, A. [IUT de Valenciennes, Departement Mesures Physiques, UVHC, Z.I. du Champ de l' Abbesse, 59600 Maubeuge (France); Jouan, P.-Y. [IUT de Valenciennes, Departement Mesures Physiques, UVHC, Z.I. du Champ de l' Abbesse, 59600 Maubeuge (France)], E-mail: pierre-yves.jouan@univ-valenciennes.fr; Zadam, M. [Electronic Department, Badji Mokhtar University, BP12 Annaba (Algeria)

    2008-01-15

    This paper deals with experimental design applied to response surface methodology (RSM) in order to determine the influence of the discharge conditions on preferred c-axis orientation of sputtered AlN thin films. The thin films have been deposited by DC reactive magnetron sputtering on Si (1 0 0) substrates. The preferred orientation was evaluated using a conventional Bragg-Brentano X-ray diffractometer ({theta}-2{theta}) with the CuK{alpha} radiation. We have first determined the experimental domain for 3 parameters: sputtering pressure (2-6 mTorr), discharge current (312-438 mA) and nitrogen percentage (17-33%). For the setup of the experimental design we have used a three factors Doehlert matrix which allows the use of the statistical response surface methodology (RSM) in a spherical domain. A four dimensional surface response, which represents the (0 0 0 2) peak height as a function of sputtering pressure, discharge current and nitrogen percentage, was obtained. It has been found that the main interaction affecting the preferential c-axis orientation was the pressure-nitrogen percentage interaction. It has been proved that a Box-Cox transformation is a very useful method to interpret and discuss the experimental results and leads to predictions in good agreement with experiments.

  15. A Programming Environment Evaluation Methodology for Object-Oriented Systems. Ph.D Thesis Final Report, 1 Jul. 1985 - 31 Dec. 1987

    Science.gov (United States)

    Dominick, Wayne D. (Editor); Moreau, Dennis R.

    1987-01-01

    The object-oriented design strategy as both a problem decomposition and system development paradigm has made impressive inroads into the various areas of the computing sciences. Substantial development productivity improvements have been demonstrated in areas ranging from artificial intelligence to user interface design. However, there has been very little progress in the formal characterization of these productivity improvements and in the identification of the underlying cognitive mechanisms. The development and validation of models and metrics of this sort require large amounts of systematically-gathered structural and productivity data. There has, however, been a notable lack of systematically-gathered information on these development environments. A large part of this problem is attributable to the lack of a systematic programming environment evaluation methodology that is appropriate to the evaluation of object-oriented systems.

  16. Case Study of Oriental Medicine Treatment with Acupotomy Therapy of the Peroneal Nerve Palsy through Ultrasound Case Report

    Directory of Open Access Journals (Sweden)

    Kim Sungha

    2011-03-01

    Full Text Available Purpose: In order to estimate clinical effects of Oriental Medicine Treatment with acupotomy therapy of Peroneal nerve Palsy. Methods: From 10th June, 2010 to 19th June, 2010, 1 female patient diagnosed as Peroneal nerve Palsy(clinical diagnosed was treated with general oriental medicine therapy (acupuncture, pharmacopuncture,moxibustion, cupping, physical therapy, herbal medication and acupotomy. Results: The patient's left foot drop was remarkably improved. Conclusions: This study demonstrates that oriental medical treatment with acuputomy therapy has notable effect in improving symptoms of peroneal nerve palsy. as though we had not wide experience in this treatment, more research is needed.

  17. Study of secondary recrystallization in grain-oriented steel treated under dynamical heat treatment conditions

    Directory of Open Access Journals (Sweden)

    V. Stoyka

    2009-04-01

    Full Text Available The present study was made to investigate secondary recrystallization in grain-oriented steels annealed at short time temperature exposures with application of dynamical heating. The investigated GO steels for experiments were taken from one industrial line after final cold rolling reduction and subsequent box annealing. It was shown that application of short time heat treatment conditions could lead to complete abnormal grain growth in the investigated GO steel. The texture and microstructure obtained in the laboratory treated material is similar to that observed in the same GO steel taken after industrial final box-annealing. However, some “parasitic” grains were observed in the secondary recrystallized matrix of the laboratory treated GO steel. These “parasitic” grains possess the unwanted from magnetic properties point of view {111} orientation components.

  18. Clinical Report of Oriental Medicine Treatment with Bee Venom Therapy of Progressive muscle atrophy 1 Patient

    Directory of Open Access Journals (Sweden)

    Kim Young-Ho

    2000-07-01

    Full Text Available The authors reports in order to study the effect of Bee Venom therapy of progressive muscle atrophy. The authors investigated 1 patient who is treated at Woosuk University Oriental Medical Hospital. The patient diagnosed by MRI EMG Hematology Muscle biopsy as progressive muscle atrophy is administered by Bee Venom therapy for 4 months. Bee Venom therapy is operated by 2 times per a week(every 3 days, 0.1cc per one operation, 0.05cc per one acupuncture point. The authors checked changes of this patient's chief symptoms by comparing before and after Bee Venom therapy is operated at 30 times. After Bee Venom therapy, the patient increased motor power & ROM, decreased general cooling sense & swallowing disorder. As above, the authors conclude that better results can be obtained Oriental Medical Treatment with Bee Venom therapy in progressive muscle atrophy

  19. What Drives Juvenile Probation Officers? Relating Organizational Contexts, Status Characteristics, and Personal Convictions to Treatment and Punishment Orientations

    Science.gov (United States)

    Ward, Geoff; Kupchik, Aaron

    2010-01-01

    Data from surveys of juvenile court probation officers in four states are analyzed to understand professional orientations toward two seemingly contrasting goals of contemporary juvenile justice systems: punishment and treatment. These self-reported juvenile probation officer orientations are considered in relation to three clusters of variables…

  20. Methodology of adjustment point in the post treatment of gaseous effluents

    International Nuclear Information System (INIS)

    Vizuet G, J.; Molina, G.

    2005-01-01

    The methodology to determine the adjustment points of the monitoring system of gaseous discharges is based on the stipulations of the 10CFR20, which are expressed in terms of limit concentrations for the outstanding radionuclides, and of dose limits for the individuals members of the public. Besides the points of liberation properly said, like they are the chimneys of the reactor buildings and of turbine, the points of adjustment of the monitoring instrumentation that watches in real time the discharge of the Treatment system of output gases, to the HVAC of the waste building; they also undergo to the same methodology, with the approaches previously described. (Author)

  1. Nationalism Studies between Methodological Nationalism and Orientalism : An Alternative Approach Illustrated with the Case of El Greco in Toledo, Spain

    NARCIS (Netherlands)

    Storm, H.J.

    2015-01-01

    Methodological nationalism is still dominant in nationalism studies. When studying the construction of national identities, scholars generally limit their study to the borders of one nation-state, while only paying attention to members of that particular nation. Implicitly, foreign actors and

  2. Veteran satisfaction and treatment preferences in response to a posttraumatic stress disorder specialty clinic orientation group.

    Science.gov (United States)

    Schumm, Jeremiah A; Walter, Kristen H; Bartone, Anne S; Chard, Kathleen M

    2015-06-01

    To maximize accessibility to evidence-based treatments for posttraumatic stress disorder (PTSD), the United States Department of Veterans Affairs (VA) has widely disseminated cognitive processing therapy (CPT) and prolonged exposure (PE) therapy to VA clinicians. However, there is a lack of research on veteran preferences when presented with a range of psychotherapy and medication options. This study uses a mixed-method approach to explore veteran satisfaction with a VA PTSD specialty clinic pre-treatment orientation group, which provides education about available PTSD treatment options. This study also tested differences in treatment preference in response to the group. Participants were 183 US veterans. Most were White, male, and referred to the clinic by a VA provider. Results indicated high satisfaction with the group in providing an overview of services and helping to inform treatment choice. Most preferred psychotherapy plus medications (63.4%) or psychotherapy only (30.1%). Participants endorsed a significantly stronger preference for CPT versus other psychotherapies. PE was significantly preferred over nightmare resolution therapy and present-centered therapy, and both PE and cognitive-behavioral conjoint therapy were preferred over virtual reality exposure therapy. Results suggest that by informing consumers about evidence-based treatments for PTSD, pre-treatment educational approaches may increase consumer demand for these treatment options. Published by Elsevier Ltd.

  3. Effect of grain orientation and heat treatment on mechanical properties of pure W

    Energy Technology Data Exchange (ETDEWEB)

    Noto, Hiroyuki, E-mail: noto_hiroyuki@iae.kyoto-u.ac.jp [Graduate School of Energy Science, Kyoto University, Kyoto 611-0011 (Japan); Research Fellow of Japan Society for the Promotion of Science (Japan); Taniguchi, Shuichi [Graduate School of Energy Science, Kyoto University, Kyoto 611-0011 (Japan); Kurishita, Hiroaki; Matsuo, Satoru [International Research Center for Nuclear Materials Science, Institute for Materials Research, Tohoku University, Oarai, Ibaraki 311-1313 (Japan); Ukita, Takashi; Tokunaga, Kazutoshi [Institute for Applied Mechanics, Kyushu University, Kasuga, Fukuoka 816-8580 (Japan); Kimura, Akihiko [Institute of Advanced Energy, Kyoto University, Kyoto 611-0011 (Japan)

    2014-12-15

    The effect of grain orientation, heat-treatment temperature and test temperature on the mechanical properties of tungsten (W), which vary depending on plastic working and fabrication process, was investigated by mechanical testing of tensile or bending. Heavily worked W samples (1.5–2.0 mm in the final thickness) exhibit degradation of fracture strength due to recrystallization embrittlement after heat-treatment at 1240 °C (temperature of diffusion bonding between W and a candidate material of the Fe base support structure). On the other hand, W samples with lower thickness reduction rates do not suffer degradation of fracture strength after heating up to around 1300 °C, and show somewhat higher fracture strength by heat-treatment below 1300 °C than the samples in the as-received state. The observed behavior is a reflection of recovery of dislocations introduced by plastic working. High temperature tensile testing of ITER grade W with an anisotropic grain structure and S-TUN with an equiaxed grain structure revealed that both W grades exhibit plastic elongation at temperatures higher than 200 °C with essentially the same temperature dependence of yield strength, which is relatively insensitive to grain orientation in the structure at 200–1300 °C.

  4. Effect of grain orientation and heat treatment on mechanical properties of pure W

    International Nuclear Information System (INIS)

    Noto, Hiroyuki; Taniguchi, Shuichi; Kurishita, Hiroaki; Matsuo, Satoru; Ukita, Takashi; Tokunaga, Kazutoshi; Kimura, Akihiko

    2014-01-01

    The effect of grain orientation, heat-treatment temperature and test temperature on the mechanical properties of tungsten (W), which vary depending on plastic working and fabrication process, was investigated by mechanical testing of tensile or bending. Heavily worked W samples (1.5–2.0 mm in the final thickness) exhibit degradation of fracture strength due to recrystallization embrittlement after heat-treatment at 1240 °C (temperature of diffusion bonding between W and a candidate material of the Fe base support structure). On the other hand, W samples with lower thickness reduction rates do not suffer degradation of fracture strength after heating up to around 1300 °C, and show somewhat higher fracture strength by heat-treatment below 1300 °C than the samples in the as-received state. The observed behavior is a reflection of recovery of dislocations introduced by plastic working. High temperature tensile testing of ITER grade W with an anisotropic grain structure and S-TUN with an equiaxed grain structure revealed that both W grades exhibit plastic elongation at temperatures higher than 200 °C with essentially the same temperature dependence of yield strength, which is relatively insensitive to grain orientation in the structure at 200–1300 °C

  5. Deployment evaluation methodology for the electrometallurgical treatment of DOE-EM spent nuclear fuel

    International Nuclear Information System (INIS)

    Dahl, C.A.; Adams, J.P.; Ramer, R.J.

    1998-07-01

    Part of the Department of Energy (DOE) spent nuclear fuel (SNF) inventory may require some type of treatment to meet acceptance criteria at various disposition sites. The current focus for much of this spent nuclear fuel is the electrometallurgical treatment process under development at Argonne National Laboratory. Potential flowsheets for this treatment process are presented. Deployment of the process for the treatment of the spent nuclear fuel requires evaluation to determine the spent nuclear fuel program need for treatment and compatibility of the spent nuclear fuel with the process. The evaluation of need includes considerations of cost, technical feasibility, process material disposition, and schedule to treat a proposed fuel. A siting evaluation methodology has been developed to account for these variables. A work breakdown structure is proposed to gather life-cycle cost information to allow evaluation of alternative siting strategies on a similar basis. The evaluation methodology, while created specifically for the electrometallurgical evaluation, has been written such that it could be applied to any potential treatment process that is a disposition option for spent nuclear fuel. Future work to complete the evaluation of the process for electrometallurgical treatment is discussed

  6. Methodology for Determining Increases in Radionuclide Inventories for the Effluent Treatment Facility Process

    International Nuclear Information System (INIS)

    Blanchard, A.

    1998-01-01

    A study is currently underway to determine if the Effluent Treatment Facility can be downgraded from a Hazard Category 3 facility to a Radiological Facility per DOE STD-1027-92. This technical report provides a methodology to determine and monitor increases in the radionuclide inventories of the ETF process columns. It also provides guidelines to ensure that other potential increases to the ETF radionuclide inventory are evaluated as required to ensure that the ETF remains a Radiological Facility

  7. Implementation of Electronic Health Records and Entrepreneurial Strategic Orientation in Substance Use Disorder Treatment Organizations.

    Science.gov (United States)

    Fields, Dail; Riesenmy, Kelly; Blum, Terry C; Roman, Paul M

    2015-11-01

    This research studied the relationships of the components of entrepreneurial strategic orientation (ESO) with implementation of electronic health records (EHRs) within organizations that treat patients with substance use disorders (SUDs). A national sample of 317 SUD treatment providers were studied in a period after the Health Information Technology for Economic and Clinical Health (HITECH) Act was enacted (2009) and meaningful use EHR requirements were established (2010), but before implementation of the Affordable Care Act. The study sample was selected using stratified random sampling and was part of a longitudinal study of treatment providers across the United States. After we controlled for potentially confounding variables, four components of ESO had a significant relationship with EHR implementation. Levels of slack resources in an organization moderated the relationship of ESO with meaningful use of EHRs, increasing the strength of the relationship for some components but reducing the strength of others. From a policy and practice perspective, the results suggest that training and education to develop higher levels of ESO within SUD treatment organizations are likely to increase their level of meaningful use of EHRs, which in turn may enhance the integration of SUD treatment with primary medical providers, better preparing SUD treatment providers for the environmental changes of the Affordable Care Act.

  8. ANALYSIS OF LEGAL AND METHODOLOGICAL GROUNDS FOR RISK-ORIENTED SURVEILLANCE OVER CONSUMER PRODUCTS: TASKS AND DEVELOPMENT PROSPECTS IN THE EURASIAN ECONOMIC UNION

    Directory of Open Access Journals (Sweden)

    N.V. Zaitseva

    2017-12-01

    Full Text Available The paper dwells on basic legal and sub-legislative documents issued in the EU, the USA, Canada, by the WTO and Codex Alimentarius Commission which provide control of consumer products safety on the basis of assessing risks for consumers' life and health. Risk-oriented surveillance is shown as a system which makes for lower loads on business but still provides systemic control over most hazardous products. The EU legislation fixes the right to perform supranational control over state control systems existing in the EU member states in terms of their relevance and legitimacy. This supranational control is supported by organizational structures and regulatory and methodological documents. National control systems are systematically reviewed and analyzed in order to secure their conformity to supranational regulatory acts, to detect any cases of non-compliance, and to spread the best practices. Risk analysis reviews and results are open and discussable. As a result of products hazards assessment their turnover can be limited, or they can be withdrawn from the market, or additional information on hazards or risks they may cause is to be provided for consumers. Public and constantly operating systems of informing about hazardous goods are well-developed. International experience and practices in the sphere of risk-oriented surveillance over consumer products can be and should be applied in the Eurasian Economic Union (EEU countries. The Eurasian Economic Union countries fix orientation at observing consumer goods safety principles in their legislation. There are also legal grounds for and practices in the sphere of risk-oriented approach to products manufactures. But it is necessary to further develop a products classification system as per consumer health risk parameters. And this task requires working out unified approaches to classification of both eatable and non-eatable products. It seems relevant to develop a public analytical database of risk-oriented

  9. The methodological quality of systematic reviews comparing temporomandibular joint disorder surgical and non-surgical treatment

    Directory of Open Access Journals (Sweden)

    Vasconcelos Belmiro CE

    2008-09-01

    Full Text Available Abstract Background Temporomandibular joint disorders (TMJD are multifactor, complex clinical problems affecting approximately 60–70% of the general population, with considerable controversy about the most effective treatment. For example, reports claim success rates of 70% and 83% for non-surgical and surgical treatment, whereas other reports claim success rates of 40% to 70% for self-improvement without treatment. Therefore, the purpose of this study was to (1 identify systematic reviews comparing temporomandibular joint disorder surgical and non-surgical treatment, (2 evaluate their methodological quality, and (3 evaluate the evidence grade within the systematic reviews. Methods A search strategy was developed and implemented for MEDLINE, Cochrane Library, LILACS, and Brazilian Dentistry Bibliography databases. Inclusion criteria were: systematic reviews (± meta-analysis comparing surgical and non-surgical TMJD treatment, published in English, Spanish, Portuguese, Italian, or German between the years 1966 and 2007(up to July. Exclusion criteria were: in vitro or animal studies; narrative reviews or editorials or editorial letters; and articles published in other languages. Two investigators independently selected and evaluated systematic reviews. Three different instruments (AMSTAR, OQAQ and CASP were used to evaluate methodological quality, and the results averaged. The GRADE instrument was used to evaluate the evidence grade within the reviews. Results The search strategy identified 211 reports; of which 2 were systematic reviews meeting inclusion criteria. The first review met 23.5 ± 6.0% and the second met 77.5 ± 12.8% of the methodological quality criteria (mean ± sd. In these systematic reviews between 9 and 15% of the trials were graded as high quality, and 2 and 8% of the total number of patients were involved in these studies. Conclusion The results indicate that in spite of the widespread impact of TMJD, and the multitude of

  10. Preliminary study for treatment methodology establishment of liquid waste containing uranium in refining facility lagoon

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byung Jik; Lee, Kune Woo; Won, Hui Jun; Ahn, Byung Gil; Shim, Joon Bo

    1999-12-01

    The preliminary study which establishes the treatment methodology of the sludge waste containing uranium in the conversion facility lagoon was performed. The property of lagoon liquid waste such as the initial water content, the density including radiochemical analysis results were obtained using the samples taken from the lagoon. The objective of this study is to provide some basically needed materials for selection of the most proper lagoon waste treatment methodology by reviewing the effective processes and methods for minimizing the secondary waste resulting from the treatment and disposition of large amount of radioactive liquid waste according to the facility closing. The lagoon waste can be classified into two sorts, such as supernatant and precipitate. The supernatants contain uranium less than 5 ppm and their water content are about 35 percent. Therefore, supernatants are solutions composed of mainly salt components. However, the precipitates have lots of uranium compound contained in the coagulation matrix, and are formed as two kinds of crystalline structures. The most proper method minimizing the secondary waste would be direct drying and solidification of the supernatants and precipitates after separation of them by filtering. (author)

  11. Environmental integrated impact assessment for waste treatment activity: methodology and case-study application

    International Nuclear Information System (INIS)

    Lonati, G.; Panzeri, A.

    2008-01-01

    A literature method for the environmental integrated impact assessment, according to the IPPC Directive, has been critically analysed and adjusted in order to be used for the environmental performance assessment of waste treatment activities. The assessment parameters, sorted in eight treatment and combined pollution categories, have been partly redefined and re balanced. The adjusted methodology has been applied to a real case-study, a chemical- physical waste treatment plant, in order to calculate the current performance (Actual Integrated Index) and the ideal performance (Actual Integrated Index) achievable by technical and operational improvements. The adjusted methodology has also been used as a decision support system, in order to estimate the value of the expected environmental performances improvement after the execution achievable from the introduction of a single one or a set of improvement actions. The valuation of the Integrated Index percentage reduction, along with the action achievable, made the best actions able to be identified, both in comparative way and in the cost-effective one. The results, 50 as Effective Integrated Index and 42 as Ideal Integrated Index, in a 10-100 scale, show a medium impact level and point out an appreciable improvement margin on all the environmental performances, especially in air emission control and water consumption [it

  12. Chinese herbal medicine for the treatment of primary hypertension: a methodology overview of systematic reviews.

    Science.gov (United States)

    Xinke, Zhao; Yingdong, Li; Mingxia, Feng; Kai, Liu; Kaibing, Chen; Yuqing, Lu; Shaobo, Sun; Peng, Song; Bin, Liu

    2016-10-20

    Chinese herbal medicine has been used to treat hypertension in China and East Asia since centuries. In this study, we conduct an overview of systematic reviews of Chinese herbal medicine in the treatment of primary hypertension to 1) summarize the conclusions of these reviews, 2) evaluate the methodological quality of these reviews, and 3) rate the confidence in the effect on each outcome. We comprehensively searched six databases to retrieve systematic reviews of Chinese herbal medicine for primary hypertension from inception to December 31, 2015. We used AMSTAR to evaluate the methodological quality of included reviews, and we classified the quality of evidence for each outcome in included reviews using the GRADE approach. A total of 12 systematic reviews with 31 outcomes were included, among which 11 systematic reviews focus on the therapeutic effect of Chinese herbal medicine combined with conventional medicine or simple Chinese herbal medicine versus simple conventional medicine. Among the 11 items of AMSTAR, the lowest quality was "providing a priori design" item, none review conformed to this item, the next was "stating the conflict of interest" item, only three reviews conformed to this item. Five reviews scored less than seven in AMSTAR, which means that the overall methodological quality was fairly poor. For GRADE, of the 31 outcomes, the quality of evidence was high in none (0 %), moderate in three (10 %), low in 19 (61 %), and very low in nine (29 %). Of the five downgrading factors, risk of bias (100 %) was the most common downgrading factor in the included reviews, followed by imprecision (42 %), inconsistency (39 %), publication bias (39 %), and indirectness (0 %). The methodological quality of systematic reviews about Chinese herbal medicine for primary hypertension is fairly poor, and the quality of evidence level is low. Physicians should be cautious when applying the interventions in these reviews for primary hypertension patients in

  13. [Detailed methodological recommendations for the treatment of Clostridium difficile-associated diarrhea with faecal transplantation].

    Science.gov (United States)

    Nagy, Gergely György; Várvölgyi, Csaba; Balogh, Zoltán; Orosi, Piroska; Paragh, György

    2013-01-06

    The incidence of Clostridium difficile associated enteral disease shows dramatic increase worldwide, with appallingly high treatment costs, mortality figures, recurrence rates and treatment refractoriness. It is not surprising, that there is significant interest in the development and introduction of alternative therapeutic strategies. Among these only stool transplantation (or faecal bacteriotherapy) is gaining international acceptance due to its excellent cure rate (≈92%), low recurrence rate (≈6%), safety and cost-effectiveness. Unfortunately faecal transplantation is not available for most patients, although based on promising international results, its introduction into the routine clinical practice is well justified and widely expected. The authors would like to facilitate this process, by presenting a detailed faecal transplantation protocol prepared in their Institution based on the available literature and clinical rationality. Officially accepted national methodological guidelines will need to be issued in the future, founded on the expert opinion of relevant professional societies and upcoming advances in this field.

  14. Optimization of petroleum refinery effluent treatment in a UASB reactor using response surface methodology

    International Nuclear Information System (INIS)

    Rastegar, S.O.; Mousavi, S.M.; Shojaosadati, S.A.; Sheibani, S.

    2011-01-01

    Highlights: ► A UASB was successfully used for treatment of petroleum refinery effluent. ► Response surface methodology was applied to design and analysis of experiments. ► System was modeled between efficient factors include HRT, influent COD and V up . ► UASB was able to remove about 76.3% influent COD at optimum conditions. - Abstract: An upflow anaerobic sludge blanket (UASB) bioreactor was successfully used for the treatment of petroleum refinery effluent. Before optimization, chemical oxygen demand (COD) removal was 81% at a constant organic loading rate (OLR) of 0.4 kg/m 3 d and a hydraulic retention time (HRT) of 48 h. The rate of biogas production was 559 mL/h at an HRT of 40 h and an influent COD of 1000 mg/L. Response surface methodology (RSM) was applied to predict the behaviors of influent COD, upflow velocity (V up ) and HRT in the bioreactor. RSM showed that the best models for COD removal and biogas production rate were the reduced quadratic and cubic models, respectively. The optimum region, identified based on two critical responses, was an influent COD of 630 mg/L, a V up of 0.27 m/h, and an HRT of 21.4 h. This resulted in a 76.3% COD removal efficiency and a 0.25 L biogas/L feed d biogas production rate.

  15. SCIRehab uses practice-based evidence methodology to associate patient and treatment characteristics with outcomes.

    Science.gov (United States)

    Whiteneck, Gale G; Gassaway, Julie

    2013-04-01

    To describe the application of practice-based evidence (PBE) methodology to spinal cord injury (SCI) rehabilitation in the SCIRehab study, and to summarize associations of patient characteristics and treatment interventions to outcomes. Prospective observational study. Six SCI rehabilitation centers. Patients with traumatic SCI (N=1376) admitted for first rehabilitation. Not applicable. FIM and residence at discharge, and FIM, residence, Craig Handicap Assessment and Reporting Technique, work/school status, Patient Health Questionnaire-9, Diener Satisfaction with Life Scale, rehospitalization, and presence of pressure ulcers at 1 year postinjury. Patient demographic and injury characteristics explained significant variation in rehabilitation outcomes, particularly functional outcomes. Regression modeling also identified a large number of significant associations with outcomes when total time in each discipline was modeled and when models were developed for each discipline, examining time spent in the many specific interventions provided by each discipline. The application of PBE methodology in the SCIRehab study provided extensive information about the process of inpatient SCI rehabilitation. While patient demographic and injury characteristics explain substantial variation in rehabilitation outcomes, particularly functional outcomes, significant relations also were found between the type and quantity of treatment interventions delivered by each rehabilitation discipline and a broad range of outcomes. Copyright © 2013 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  16. Sewage treatment processes: The methodology for the resort communities; Tecnologias de Depuracion: la metodologia de seleccion para poblaciones turisticas

    Energy Technology Data Exchange (ETDEWEB)

    Nieves de la Vega, G.; Kovacs, Z. [AQUA/PLAN, S.A. (Spain)

    1995-06-01

    The selection of adequate sewage treatment processes for resort communities has to be based upon a detailed knowledge of the characteristics of sewerage discharges. In order to define a methodology, the most representative variables such as climatology, seasonal variation, required treatment efficiency, sewage characteristics and availability of land, are identified. A wide range of available treatment processes is defined and the relationship between variables and priority criteria is analysed. Finally, a decision-diagram allowing the selection of the most adequate treatment process in each particular case is presented. The methodology is applied to mountain resort communities. (Author)

  17. A meta-analysis of the effectiveness of individually oriented Cognitive Behavioral Treatment (CBT) for severe agressive behavior in adolescents

    NARCIS (Netherlands)

    Hoogsteder, L.M.; Stams, G.J.J.M.; Figge, M.A.; Changoe, K.; van Horn, J.E.; Hendriks, J.; Wissink, I.B.

    2015-01-01

    This meta-analysis, including six studies (13 effect sizes) and 164 adolescents, examined the effectiveness of individually oriented treatment (which means that the intervention contained at least an individual component, possibly in combination with group and/or family therapy) with CBT-elements

  18. The Treatment of Uncertainty in Compensation Schemes for Cancer Based on the Probability of Causation Methodology

    International Nuclear Information System (INIS)

    Koch, J.

    2014-01-01

    Since it is commonly accepted that exposure to ionizing radiation, even at the low levels encountered in the workplace, can cause malignant diseases, radiation workers are at some risk, although much is done to optimize radiation protection and reduce occupational exposure to levels a s low as reasonably achievable . However, the causal relationship between exposure to radiation and malignant diseases is difficult to establish, since cancer is such a frequent disease and many other factors may contribute to its development. Ideally, those workers who developed cancer as a result of occupational exposure to radiation should be compensated. Guidance on procedures and methodology to assess attributability of cancer to occupational exposure to radiation and to assist decision-making in compensating workers is provided in a recent joint IAEA/ILO/WHO publication.This guide also reviews compensation schemes in place in several countries, with an emphasis on those based on the probability of causation (POC), also known as assigned share (AS) methodology. The POC method provides a scientifically based framework to assess cancer attributability to occupational exposure and was extensively reviewed by Wakeford et al. This paper presents a comparison of two well-known compensation schemes based on the POC approach with regard to their treatment of uncertainty

  19. Shared decision-making in medical encounters regarding breast cancer treatment: the contribution of methodological triangulation.

    Science.gov (United States)

    Durif-Bruckert, C; Roux, P; Morelle, M; Mignotte, H; Faure, C; Moumjid-Ferdjaoui, N

    2015-07-01

    The aim of this study on shared decision-making in the doctor-patient encounter about surgical treatment for early-stage breast cancer, conducted in a regional cancer centre in France, was to further the understanding of patient perceptions on shared decision-making. The study used methodological triangulation to collect data (both quantitative and qualitative) about patient preferences in the context of a clinical consultation in which surgeons followed a shared decision-making protocol. Data were analysed from a multi-disciplinary research perspective (social psychology and health economics). The triangulated data collection methods were questionnaires (n = 132), longitudinal interviews (n = 47) and observations of consultations (n = 26). Methodological triangulation revealed levels of divergence and complementarity between qualitative and quantitative results that suggest new perspectives on the three inter-related notions of decision-making, participation and information. Patients' responses revealed important differences between shared decision-making and participation per se. The authors note that subjecting patients to a normative behavioural model of shared decision-making in an era when paradigms of medical authority are shifting may undermine the patient's quest for what he or she believes is a more important right: a guarantee of the best care available. © 2014 John Wiley & Sons Ltd.

  20. Predictive Model and Methodology for Heat Treatment Distortion Final Report CRADA No. TC-298-92

    Energy Technology Data Exchange (ETDEWEB)

    Nikkel, D. J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); McCabe, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-10-16

    This project was a multi-lab, multi-partner CRADA involving LLNL, Los Alamos National Laboratory, Sandia National Laboratories, Oak Ridge National Laboratory, Martin Marietta Energy Systems and the industrial partner, The National Center of Manufacturing Sciences (NCMS). A number of member companies of NCMS participated including General Motors Corporation, Ford Motor Company, The Torrington Company, Gear Research, the Illinois Institute of Technology Research Institute, and Deformation Control Technology •. LLNL was the lead laboratory for metrology technology used for validation of the computational tool/methodology. LLNL was also the lead laboratory for the development of the software user interface , for the computational tool. This report focuses on the participation of LLNL and NCMS. The purpose of the project was to develop a computational tool/methodology that engineers would use to predict the effects of heat treatment on the _size and shape of industrial parts made of quench hardenable alloys. Initially, the target application of the tool was gears for automotive power trains.

  1. Human resource management in the project-oriented organization: Employee well-being and ethical treatment

    NARCIS (Netherlands)

    Turner, R.; Huemann, M.; Keegan, A.

    2008-01-01

    As part of a wider study into human resource management (HRM) practices in project-oriented organizations, we investigated the issue of employee well-being. Project-oriented organizations adopt temporary work processes to deliver products and services to clients. This creates a dynamic work

  2. The application of experimental design methodology for the investigation of liquid radioactive waste treatment

    Directory of Open Access Journals (Sweden)

    Šljivić-Ivanović Marija Z.

    2017-01-01

    Full Text Available The sorption properties of waste facade, brick, and asphalt sample towards Sr(II, Co(II, and Ni(II ions from single and multicomponent solutions were investigated. The highest sorption capacity was found for Ni(II ions, while the most effective sorbent was facade. Simplex Centroid Mixture Design was used in order to investigate the sorption processes of ions from solutions with different composition as well as the competition between the cations. Based on the statistical analysis results, the equations for data modeling were proposed. According to the observations, the investigated solid matrices can be effectively used for the liquid radioactive waste treatment. Furthermore, the applied methodology turned out to be an easy and operational way for the investigations of multicomponent sorption processes. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. III 43009 and Grant no. OI 171007

  3. Optimization of petroleum refinery effluent treatment in a UASB reactor using response surface methodology

    Energy Technology Data Exchange (ETDEWEB)

    Rastegar, S.O. [Biotechnology Group, Chemical Engineering Department, Tarbiat Modares University, Tehran (Iran, Islamic Republic of); Mousavi, S.M., E-mail: mousavi_m@modares.ac.ir [Biotechnology Group, Chemical Engineering Department, Tarbiat Modares University, Tehran (Iran, Islamic Republic of); Shojaosadati, S.A. [Biotechnology Group, Chemical Engineering Department, Tarbiat Modares University, Tehran (Iran, Islamic Republic of); Sheibani, S. [R and T Management Department, National Iranian Oil Refining and Distribution Company, Tehran (Iran, Islamic Republic of)

    2011-12-15

    Highlights: Black-Right-Pointing-Pointer A UASB was successfully used for treatment of petroleum refinery effluent. Black-Right-Pointing-Pointer Response surface methodology was applied to design and analysis of experiments. Black-Right-Pointing-Pointer System was modeled between efficient factors include HRT, influent COD and V{sub up}. Black-Right-Pointing-Pointer UASB was able to remove about 76.3% influent COD at optimum conditions. - Abstract: An upflow anaerobic sludge blanket (UASB) bioreactor was successfully used for the treatment of petroleum refinery effluent. Before optimization, chemical oxygen demand (COD) removal was 81% at a constant organic loading rate (OLR) of 0.4 kg/m{sup 3} d and a hydraulic retention time (HRT) of 48 h. The rate of biogas production was 559 mL/h at an HRT of 40 h and an influent COD of 1000 mg/L. Response surface methodology (RSM) was applied to predict the behaviors of influent COD, upflow velocity (V{sub up}) and HRT in the bioreactor. RSM showed that the best models for COD removal and biogas production rate were the reduced quadratic and cubic models, respectively. The optimum region, identified based on two critical responses, was an influent COD of 630 mg/L, a V{sub up} of 0.27 m/h, and an HRT of 21.4 h. This resulted in a 76.3% COD removal efficiency and a 0.25 L biogas/L feed d biogas production rate.

  4. Qualitative systematic reviews of treatment burden in stroke, heart failure and diabetes - Methodological challenges and solutions

    Science.gov (United States)

    2013-01-01

    Background Treatment burden can be defined as the self-care practices that patients with chronic illness must perform to respond to the requirements of their healthcare providers, as well as the impact that these practices have on patient functioning and well being. Increasing levels of treatment burden may lead to suboptimal adherence and negative outcomes. Systematic review of the qualitative literature is a useful method for exploring the patient experience of care, in this case the experience of treatment burden. There is no consensus on methods for qualitative systematic review. This paper describes the methodology used for qualitative systematic reviews of the treatment burdens identified in three different common chronic conditions, using stroke as our exemplar. Methods Qualitative studies in peer reviewed journals seeking to understand the patient experience of stroke management were sought. Limitations of English language and year of publication 2000 onwards were set. An exhaustive search strategy was employed, consisting of a scoping search, database searches (Scopus, CINAHL, Embase, Medline & PsycINFO) and reference, footnote and citation searching. Papers were screened, data extracted, quality appraised and analysed by two individuals, with a third party for disagreements. Data analysis was carried out using a coding framework underpinned by Normalization Process Theory (NPT). Results A total of 4364 papers were identified, 54 were included in the review. Of these, 51 (94%) were retrieved from our database search. Methodological issues included: creating an appropriate search strategy; investigating a topic not previously conceptualised; sorting through irrelevant data within papers; the quality appraisal of qualitative research; and the use of NPT as a novel method of data analysis, shown to be a useful method for the purposes of this review. Conclusion The creation of our search strategy may be of particular interest to other researchers carrying out

  5. Qualitative systematic reviews of treatment burden in stroke, heart failure and diabetes - methodological challenges and solutions.

    Science.gov (United States)

    Gallacher, Katie; Jani, Bhautesh; Morrison, Deborah; Macdonald, Sara; Blane, David; Erwin, Patricia; May, Carl R; Montori, Victor M; Eton, David T; Smith, Fiona; Batty, G David; Batty, David G; Mair, Frances S

    2013-01-28

    Treatment burden can be defined as the self-care practices that patients with chronic illness must perform to respond to the requirements of their healthcare providers, as well as the impact that these practices have on patient functioning and well being. Increasing levels of treatment burden may lead to suboptimal adherence and negative outcomes. Systematic review of the qualitative literature is a useful method for exploring the patient experience of care, in this case the experience of treatment burden. There is no consensus on methods for qualitative systematic review. This paper describes the methodology used for qualitative systematic reviews of the treatment burdens identified in three different common chronic conditions, using stroke as our exemplar. Qualitative studies in peer reviewed journals seeking to understand the patient experience of stroke management were sought. Limitations of English language and year of publication 2000 onwards were set. An exhaustive search strategy was employed, consisting of a scoping search, database searches (Scopus, CINAHL, Embase, Medline & PsycINFO) and reference, footnote and citation searching. Papers were screened, data extracted, quality appraised and analysed by two individuals, with a third party for disagreements. Data analysis was carried out using a coding framework underpinned by Normalization Process Theory (NPT). A total of 4364 papers were identified, 54 were included in the review. Of these, 51 (94%) were retrieved from our database search. Methodological issues included: creating an appropriate search strategy; investigating a topic not previously conceptualised; sorting through irrelevant data within papers; the quality appraisal of qualitative research; and the use of NPT as a novel method of data analysis, shown to be a useful method for the purposes of this review. The creation of our search strategy may be of particular interest to other researchers carrying out synthesis of qualitative studies

  6. 42 CFR 413.220 - Methodology for calculating the per-treatment base rate under the ESRD prospective payment system...

    Science.gov (United States)

    2010-10-01

    ... rate under the ESRD prospective payment system effective January 1, 2011. 413.220 Section 413.220...-treatment base rate under the ESRD prospective payment system effective January 1, 2011. (a) Data sources. The methodology for determining the per treatment base rate under the ESRD prospective payment system...

  7. Optimization of Electrochemical Treatment Process Conditions for Distillery Effluent Using Response Surface Methodology

    Directory of Open Access Journals (Sweden)

    P. Arulmathi

    2015-01-01

    Full Text Available Distillery industry is recognized as one of the most polluting industries in India with a large amount of annual effluent production. In this present study, the optimization of electrochemical treatment process variables was reported to treat the color and COD of distillery spent wash using Ti/Pt as an anode in a batch mode. Process variables such as pH, current density, electrolysis time, and electrolyte dose were selected as operation variables and chemical oxygen demand (COD and color removal efficiency were considered as response variable for optimization using response surface methodology. Indirect electrochemical-oxidation process variables were optimized using Box-Behnken response surface design (BBD. The results showed that electrochemical treatment process effectively removed the COD (89.5% and color (95.1% of the distillery industry spent wash under the optimum conditions: pH of 4.12, current density of 25.02 mA/cm2, electrolysis time of 103.27 min, and electrolyte (NaCl concentration of 1.67 g/L, respectively.

  8. Lumbar Sympathetic Plexus Block as a Treatment for Postamputation Pain: Methodology for a Randomized Controlled Trial.

    Science.gov (United States)

    McCormick, Zachary L; Hendrix, Andrew; Dayanim, David; Clay, Bryan; Kirsling, Amy; Harden, Norman

    2018-03-08

    We present a technical protocol for rigorous assessment of patient-reported outcomes and psychophysical testing relevant to lumbar sympathetic blocks for the treatment of postamputation pain (PAP). This description is intended to inform future prospective investigation. Series of four participants from a blinded randomized sham-controlled trial. Tertiary, urban, academic pain medicine center. Four participants with a single lower limb amputation and associated chronic PAP. Participants were randomized to receive a lumbar sympathetic block with 0.25% bupivacaine or sham needle placement. Patient-rated outcome measures included the numerical rating scale (NRS) for pain, the McGill Pain Questionnaire-Short Form, Center for Epidemiological Studies Depression Scale, Pain and Anxiety Symptoms Scale-short version, and Pain Disability Index (PDI). Psychophysical and biometric testing was also performed, which included vibration sensation testing, pinprick sensation testing, brush sensation testing, Von Frey repeated weighted pinprick sensation, and thermal quantitative sensory testing. In the four described cases, treatment of PAP with a single lumbar sympathetic block but not sham intervention resulted in reduction of both residual limb pain and phantom limb pain as well as perceived disability on the PDI at three-month follow-up. An appropriately powered randomized controlled study using this methodology may not only aid in determining the possible clinical efficacy of lumbar sympathetic block in PAP, but could also improve our understanding of underlying pathophysiologic mechanisms of PAP.

  9. Innovative research methods for studying treatments for rare diseases: methodological review.

    Science.gov (United States)

    Gagne, Joshua J; Thompson, Lauren; O'Keefe, Kelly; Kesselheim, Aaron S

    2014-11-24

    To examine methods for generating evidence on health outcomes in patients with rare diseases. Methodological review of existing literature. PubMed, Embase, and Academic Search Premier searched for articles describing innovative approaches to randomized trial design and analysis methods and methods for conducting observational research in patients with rare diseases. We assessed information related to the proposed methods, the specific rare disease being studied, and outcomes from the application of the methods. We summarize methods with respect to their advantages in studying health outcomes in rare diseases and provide examples of their application. We identified 46 articles that proposed or described methods for studying patient health outcomes in rare diseases. Articles covered a wide range of rare diseases and most (72%) were published in 2008 or later. We identified 16 research strategies for studying rare disease. Innovative clinical trial methods minimize sample size requirements (n=4) and maximize the proportion of patients who receive active treatment (n=2), strategies crucial to studying small populations of patients with limited treatment choices. No studies describing unique methods for conducting observational studies in patients with rare diseases were identified. Though numerous studies apply unique clinical trial designs and considerations to assess patient health outcomes in rare diseases, less attention has been paid to innovative methods for studying rare diseases using observational data. © Gagne et al 2014.

  10. Human resource management in the project-oriented organization: Employee well-being and ethical treatment

    OpenAIRE

    Turner, R.; Huemann, M.; Keegan, A.

    2008-01-01

    As part of a wider study into human resource management (HRM) practices in project-oriented organizations, we investigated the issue of employee well-being. Project-oriented organizations adopt temporary work processes to deliver products and services to clients. This creates a dynamic work environment, where additional pressures can be imposed on the employee from fluctuating work-loads, uncertain requirements, and multiple role demands. These pressures can create issues for employee well-be...

  11. Reducing DNACPR complaints to zero: designing and implementing a treatment escalation plan using quality improvement methodology.

    Science.gov (United States)

    Shermon, Elizabeth; Munglani, Laura; Oram, Sarah; William, Linda; Abel, Julian

    2017-01-01

    Do Not Attempt Resuscitation (DNAR)decisions have traditionally formed the basis of ceiling of care discussions. However, poor quality discussions can lead to high patient and relative dissatisfaction, generating hospital complaints. Treatment escalation plans (TEPs) aim to highlight the wider remit of treatment options with a focus on effective communication. We aimed to improve TEP discussions and documentation at Weston General Hospital by introducing a standardised form. We aimed to develop a TEP document to reduce resuscitation-related complaints by improving communication and documentation. Qualitative and quantitative data were collected over 2 years and used to develop plan-do-study-act (PDSA) cycles using quality improvement methodology. Main barriers to improvement included time constraints and clinician's resistance. Analysis of patient liaison services data showed a progressive reduction in complaints regarding resuscitation, with no complaints having been received for the final six months of the project. Through use of a standardised form including treatment prompts, the quality of discussions and plans improved. Qualitative feedback demonstrated increased patient and relative satisfaction. In addition, junior doctors report the plans are helpful when making out-of-hours decisions. Development of a user-friendly form to document patient-guided TEPs helped junior doctors to lead advanced care planning discussions. The use of PDSA cycles demonstrated improvement in the quality of forms, which in turn improved communication, documentation and satisfaction. Future developments could include involvement of specialist teams to ensure TEP forms remain relevant to all clinical areas. In addition, with widespread use of the TEP forms, the traditional tick-box DNAR could be replaced to focus on patient-led care planning.

  12. A consistent modelling methodology for secondary settling tanks in wastewater treatment.

    Science.gov (United States)

    Bürger, Raimund; Diehl, Stefan; Nopens, Ingmar

    2011-03-01

    The aim of this contribution is partly to build consensus on a consistent modelling methodology (CMM) of complex real processes in wastewater treatment by combining classical concepts with results from applied mathematics, and partly to apply it to the clarification-thickening process in the secondary settling tank. In the CMM, the real process should be approximated by a mathematical model (process model; ordinary or partial differential equation (ODE or PDE)), which in turn is approximated by a simulation model (numerical method) implemented on a computer. These steps have often not been carried out in a correct way. The secondary settling tank was chosen as a case since this is one of the most complex processes in a wastewater treatment plant and simulation models developed decades ago have no guarantee of satisfying fundamental mathematical and physical properties. Nevertheless, such methods are still used in commercial tools to date. This particularly becomes of interest as the state-of-the-art practice is moving towards plant-wide modelling. Then all submodels interact and errors propagate through the model and severely hamper any calibration effort and, hence, the predictive purpose of the model. The CMM is described by applying it first to a simple conversion process in the biological reactor yielding an ODE solver, and then to the solid-liquid separation in the secondary settling tank, yielding a PDE solver. Time has come to incorporate established mathematical techniques into environmental engineering, and wastewater treatment modelling in particular, and to use proven reliable and consistent simulation models. Copyright © 2011 Elsevier Ltd. All rights reserved.

  13. A new methodological approach for PET implementation in radiotherapy treatment planning.

    Science.gov (United States)

    Bellan, Elena; Ferretti, Alice; Capirci, Carlo; Grassetto, Gaia; Gava, Marcello; Chondrogiannis, Sotirios; Virdis, Graziella; Marzola, Maria Cristina; Massaro, Arianna; Rubello, Domenico; Nibale, Otello

    2012-05-01

    In this paper, a new methodological approach to using PET information in radiotherapy treatment planning has been discussed. Computed tomography (CT) represents the primary modality to plan personalized radiation treatment, because it provides the basic electron density map for correct dose calculation. If PET scanning is also performed it is typically coregistered with the CT study. This operation can be executed automatically by a hybrid PET/CT scanner or, if the PET and CT imaging sets have been acquired through different equipment, by a dedicated module of the radiotherapy treatment planning system. Both approaches have some disadvantages: in the first case, the bore of a PET/CT system generally used in clinical practice often does not allow the use of certain bulky devices for patient immobilization in radiotherapy, whereas in the second case the result could be affected by limitations in window/level visualization of two different image modalities, and the displayed PET volumes can appear not to be related to the actual uptake into the patient. To overcome these problems, at our centre a specific procedure has been studied and tested in 30 patients, allowing good results of precision in the target contouring to be obtained. The process consists of segmentation of the biological target volume by a dedicated PET/CT console and its export to a dedicated radiotherapy system, where an image registration between the CT images acquired by the PET/CT scanner and a large-bore CT is performed. The planning target volume is contoured only on the large-bore CT and is used for virtual simulation, to individuate permanent skin markers on the patient.

  14. Culture-sensitive adaptation and validation of the community-oriented program for the control of rheumatic diseases methodology for rheumatic disease in Latin American indigenous populations.

    Science.gov (United States)

    Peláez-Ballestas, Ingris; Granados, Ysabel; Silvestre, Adriana; Alvarez-Nemegyei, José; Valls, Evart; Quintana, Rosana; Figuera, Yemina; Santiago, Flor Julian; Goñi, Mario; González, Rosa; Santana, Natalia; Nieto, Romina; Brito, Irais; García, Imelda; Barrios, Maria Cecilia; Marcano, Manuel; Loyola-Sánchez, Adalberto; Stekman, Ivan; Jorfen, Marisa; Goycochea-Robles, Maria Victoria; Midauar, Fadua; Chacón, Rosa; Martin, Maria Celeste; Pons-Estel, Bernardo A

    2014-09-01

    The purpose of the study is to validate a culturally sensitive adaptation of the community-oriented program for the control of rheumatic diseases (COPCORD) methodology in several Latin American indigenous populations. The COPCORD Spanish questionnaire was translated and back-translated into seven indigenous languages: Warao, Kariña and Chaima (Venezuela), Mixteco, Maya-Yucateco and Raramuri (Mexico) and Qom (Argentina). The questionnaire was administered to almost 100 subjects in each community with the assistance of bilingual translators. Individuals with pain, stiffness or swelling in any part of the body in the previous 7 days and/or at any point in life were evaluated by physicians to confirm a diagnosis according to criteria for rheumatic diseases. Overall, individuals did not understand the use of a 0-10 visual analog scale for pain intensity and severity grading and preferred a Likert scale comprising four items for pain intensity (no pain, minimal pain, strong pain, and intense pain). They were unable to discriminate between pain intensity and pain severity, so only pain intensity was included. For validation, 702 subjects (286 male, 416 female, mean age 42.7 ± 18.3 years) were interviewed in their own language. In the last 7 days, 198 (28.2 %) subjects reported having musculoskeletal pain, and 90 (45.4 %) of these had intense pain. Compared with the physician-confirmed diagnosis, the COPCORD questionnaire had 73.8 % sensitivity, 72.9 % specificity, a positive likelihood ratio of 2.7 and area under the receiver operating characteristic curve of 0.73. The COPCORD questionnaire is a valid screening tool for rheumatic diseases in indigenous Latin American populations.

  15. Sexual orientation and sexual behavior among Latino and Asian Americans: implications for unfair treatment and psychological distress.

    Science.gov (United States)

    Chae, David H; Ayala, George

    2010-09-01

    Research on the sexuality of Asians and Latinos in the United States has been sparse, and the studies that have been done suffer from a number of limitations. Using data from the National Latino and Asian American Study (2002-2003), this study examined self-identified sexual orientation and self-reported sexual behavior among Latinos (n = 2,554; age: M = 38.1, SE = 0.5) and Asians (n = 2,095; age: M = 41.5, SE = 0.8). This study also investigated implications for unfair treatment and psychological distress among sexual minorities identified in the sample. Results indicated heterogeneity in responses to items assessing sexual orientation and sexual behavior including differences in the adoption of lesbian, gay, or bisexual (LGB) identity by gender, ethnicity, nativity, and socioeconomic status. LGB sexual minorities reported higher levels of unfair treatment and psychological distress compared to their non-LGB-identified sexual minority counterparts, and unfair treatment was positively associated with psychological distress. Results highlight the need to consider multiple demographic factors in assessing sexuality, and also suggest that measures of both self-identified sexual orientation and sexual behavior should be collected. In addition, findings provide support for the deleterious influence of unfair treatment among Asians and Latinos in the United States.

  16. Virtual reality exposure therapy for the treatment of posttraumatic stress disorder: a methodological review using CONSORT guidelines.

    Science.gov (United States)

    Motraghi, Terri E; Seim, Richard W; Meyer, Eric C; Morissette, Sandra B

    2014-03-01

    Virtual reality exposure therapy (VRET) is an extension of traditional exposure therapy and has been used to treat a variety of anxiety disorders. VRET utilizes a computer-generated virtual environment to present fear-relevant stimuli. Recent studies have evaluated the use of VRET for treatment of PTSD; however, a systematic evaluation of the methodological quality of these studies has yet to be conducted. This review aims to (a) identify treatment outcome studies examining the use of VRET for the treatment of PTSD and (b) appraise the methodological quality of each study using the 2010 Consolidating Standards of Reporting Trials (CONSORT) Statement and its 2008 extension for nonpharmacologic interventions. Two independent assessors conducted a database search (PsycINFO, Medline, CINAHL, Google Scholar) of studies published between January 1990 and June 2013 that reported outcome data comparing VRET with another type of treatment or a control condition. Next, a CONSORT quality appraisal of each study was completed. The search yielded nine unique studies. The CONSORT appraisal revealed that the methodological quality of studies examining VRET as a treatment for PTSD was variable. Although preliminary findings suggest some positive results for VRET as a form of exposure treatment for PTSD, additional research using well-specified randomization procedures, assessor blinding, and monitoring of treatment adherence is warranted. Movement toward greater standardization of treatment manuals, virtual environments, and equipment would further facilitate interpretation and consolidation of this literature. © 2013 Wiley Periodicals, Inc.

  17. Lifestyle-oriented non-pharmacological treatments for fibromyalgia: a clinical overview and applications with home-based technologies

    Directory of Open Access Journals (Sweden)

    Friedberg F

    2012-10-01

    Full Text Available Fred Friedberg,1 David A Williams,2 William Collinge31Department of Psychiatry and Behavioral Science, Stony Brook University, Stony Brook, New York; 2Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, 3Collinge and Associates, Kittery, Maine, USAAbstract: Fibromyalgia (FM is a persistent and disabling widespread pain condition often accompanied by chronic fatigue, cognitive problems, sleep disturbance, depression, anxiety, and headache. To date, the most thoroughly studied non-pharmacological approaches to managing FM are those with a focus on changing patient activities and beliefs that affect the illness. These interventions are intended to facilitate enduring improvement in pain and functional status. Lifestyle-oriented treatments include patient education, aerobic or other physical exercise, and cognitive-behavioral therapy (CBT. These interventions in FM can be delivered in medical or behavioral health care settings by trained professionals, through patient-oriented treatment manuals, or via remote-access technologies. Non-pharmacological treatments, in particular exercise and CBT, have yielded effect sizes and cost–benefit ratios comparable to medications. This paper describes lifestyle-oriented non-pharmacological treatments for FM and highlights selected literature reviews of these interventions. In addition, behavioral and practical issues are addressed that may affect these non-pharmacological treatments, including patient expectations, participant burden, and treatment availability. Recommendations are made to facilitate these interventions and potentially improve outcomes. In particular, the increasing availability of convenient home-based mobile technologies to deliver these non-pharmacological treatments is described.Keywords: cognitive-behavior therapy, exercise, education, mobile technology

  18. Impact of gender, sexual orientation and socio-economic factors on HIV treatment outcomes in the UK

    OpenAIRE

    Burch, Lisa Samantha

    2018-01-01

    The effectiveness of antiretroviral therapy (ART) has led to greatly improved prognosis for people living with HIV, such that they now have a similar life expectancy to the general population. However, these improvements over time have not necessarily been seen equally among all demographic groups. The aim of this thesis was to investigate the differences in virological response to ART, treatment adherence, and late HIV diagnosis by gender and sexual orientation among people with HIV in the U...

  19. Energy audit in small wastewater treatment plants: methodology, energy consumption indicators, and lessons learned.

    Science.gov (United States)

    Foladori, P; Vaccari, M; Vitali, F

    2015-01-01

    Energy audits in wastewater treatment plants (WWTPs) reveal large differences in the energy consumption in the various stages, depending also on the indicators used in the audits. This work is aimed at formulating a suitable methodology to perform audits in WWTPs and identifying the most suitable key energy consumption indicators for comparison among different plants and benchmarking. Hydraulic-based stages, stages based on chemical oxygen demand, sludge-based stages and building stages were distinguished in WWTPs and analysed with different energy indicators. Detailed energy audits were carried out on five small WWTPs treating less than 10,000 population equivalent and using continuous data for 2 years. The plants have in common a low designed capacity utilization (52% on average) and equipment oversizing which leads to waste of energy in the absence of controls and inverters (a common situation in small plants). The study confirms that there are several opportunities for reducing energy consumption in small WWTPs: in addition to the pumping of influent wastewater and aeration, small plants demonstrate low energy efficiency in recirculation of settled sludge and in aerobic stabilization. Denitrification above 75% is ensured through intermittent aeration and without recirculation of mixed liquor. Automation in place of manual controls is mandatory in illumination and electrical heating.

  20. Modeling and optimization of ammonia treatment by acidic biochar using response surface methodology

    Directory of Open Access Journals (Sweden)

    Narong Chaisongkroh

    2012-09-01

    Full Text Available Emission of ammonia (NH3 contaminated waste air to the atmosphere without treatment has affected humans andenvironment. Eliminating NH3 in waste air emitted from industries is considered an environmental requisite. In this study,optimization of NH3 adsorption time using acidic rubber wood biochar (RWBs impregnated with sulfuric acid (H2SO4 wasinvestigated. The central composite design (CCD in response surface methodology (RSM by the Design Expert softwarewas used for designing the experiments as well as the full response surface estimation. The RSM was used to evaluate theeffect of adsorption parameters in continuous mode of fixed bed column including waste air flow rate, inlet NH3 concentration in waste air stream, and H2SO4 concentration for adsorbent surface modification. Based on statistical analysis, the NH3symmetric adsorption time (at 50% NH3 removal efficiency model proved to be very highly significant (p<0.0001. The optimum conditions obtained were 300 ppmv inlet NH3 concentration, 72% H2SO4, and 2.1 l/min waste air flow rate. This resultedin 219 minutes of NH3 adsorption time as obtained from the predicted model, which fitted well with the laboratory verification result. This was supported by the high value of coefficient of determination (R2=0.9137. (NH42SO4, a nitrogen fertilizerfor planting, was the by-product from chemical adsorption between NH3 and H2SO4.

  1. Maximizing Health or Sufficient Capability in Economic Evaluation? A Methodological Experiment of Treatment for Drug Addiction.

    Science.gov (United States)

    Goranitis, Ilias; Coast, Joanna; Day, Ed; Copello, Alex; Freemantle, Nick; Frew, Emma

    2017-07-01

    Conventional practice within the United Kingdom and beyond is to conduct economic evaluations with "health" as evaluative space and "health maximization" as the decision-making rule. However, there is increasing recognition that this evaluative framework may not always be appropriate, and this is particularly the case within public health and social care contexts. This article presents a methodological case study designed to explore the impact of changing the evaluative space within an economic evaluation from health to capability well-being and the decision-making rule from health maximization to the maximization of sufficient capability. Capability well-being is an evaluative space grounded on Amartya Sen's capability approach and assesses well-being based on individuals' ability to do and be the things they value in life. Sufficient capability is an egalitarian approach to decision making that aims to ensure everyone in society achieves a normatively sufficient level of capability well-being. The case study is treatment for drug addiction, and the cost-effectiveness of 2 psychological interventions relative to usual care is assessed using data from a pilot trial. Analyses are undertaken from a health care and a government perspective. For the purpose of the study, quality-adjusted life years (measured using the EQ-5D-5L) and years of full capability equivalent and years of sufficient capability equivalent (both measured using the ICECAP-A [ICEpop CAPability measure for Adults]) are estimated. The study concludes that different evaluative spaces and decision-making rules have the potential to offer opposing treatment recommendations. The implications for policy makers are discussed.

  2. The predictive validity of the Drinking-Related Cognitions Scale in alcohol-dependent patients under abstinence-oriented treatment

    Directory of Open Access Journals (Sweden)

    Sawayama Toru

    2012-05-01

    Full Text Available Abstract Background Cognitive factors associated with drinking behavior such as positive alcohol expectancies, self-efficacy, perception of impaired control over drinking and perception of drinking problems are considered to have a significant influence on treatment effects and outcome in alcohol-dependent patients. However, the development of a rating scale on lack of perception or denial of drinking problems and impaired control over drinking has not been substantial, even though these are important factors in patients under abstinence-oriented treatment as well as participants in self-help groups such as Alcoholics Anonymous (AA. The Drinking-Related Cognitions Scale (DRCS is a new self-reported rating scale developed to briefly measure cognitive factors associated with drinking behavior in alcohol-dependent patients under abstinence-oriented treatment, including positive alcohol expectancies, abstinence self-efficacy, perception of impaired control over drinking, and perception of drinking problems. Here, we conducted a prospective cohort study to explore the predictive validity of DRCS. Methods Participants in this study were 175 middle-aged and elderly Japanese male patients who met the DSM-IV Diagnostic Criteria for Alcohol Dependence. DRCS scores were recorded before and after the inpatient abstinence-oriented treatment program, and treatment outcome was evaluated one year after discharge. Results Of the 175 participants, 30 were not available for follow-up; thus the number of subjects for analysis in this study was 145. When the total DRCS score and subscale scores were compared before and after inpatient treatment, a significant increase was seen for both scores. Both the total DRCS score and each subscale score were significantly related to total abstinence, percentage of abstinent days, and the first drinking occasion during the one-year post-treatment period. Therefore, good treatment outcome was significantly predicted by low

  3. Using a life cycle assessment methodology for the analysis of two treatment systems of food-processing industry wastewaters

    DEFF Research Database (Denmark)

    Maya Altamira, Larisa; Schmidt, Jens Ejbye; Baun, Anders

    2007-01-01

    criteria involve sludge disposal strategies and electrical energy consumption. However, there is a need to develop a systematic methodology to quantify relevant environmental indicators; comprising information of the wastewater treatment system in a life cycle perspective. Also, to identify which...... are the parameters that have the greatest influence on the potential environmental impacts of the systems analyzed. In this study, we present a systematic methodology for the analysis of the operation of two modern wastewater treatment technologies: Biological removal of nitrogen and organic matter by activated...... sludge (Scenario 1), and anaerobic removal of organic matter by a continuous stirred tank reactor (Scenario 2). Both technologies were applied to wastewater coming from a fish meals industry and a pet food industry discharging about 250 to 260 thousand cubic meters of wastewater per year. The methodology...

  4. Towards better environmental performance of wastewater sludge treatment using endpoint approach in LCA methodology

    Directory of Open Access Journals (Sweden)

    Isam Alyaseri

    2017-03-01

    Full Text Available The aim of this study is to use the life cycle assessment method to measure the environmental performance of the sludge incineration process in a wastewater treatment plant and to propose an alternative that can reduce the environmental impact. To show the damages caused by the treatment processes, the study aimed to use an endpoint approach in evaluating impacts on human health, ecosystem quality, and resources due to the processes. A case study was taken at Bissell Point Wastewater Treatment Plant in Saint Louis, Missouri, U.S. The plant-specific data along with literature data from technical publications were used to build an inventory, and then analyzed the environmental burdens from sludge handling unit in the year 2011. The impact assessment method chosen was ReCipe 2008. The existing scenario (dewatering-multiple hearth incineration-ash to landfill was evaluated and three alternative scenarios (fluid bed incineration and anaerobic digestion with and without land application with energy recovery from heat or biogas were proposed and analyzed to find the one with the least environmental impact. The existing scenario shows that the most significant impacts are related to depletion in resources and damage to human health. These impacts mainly came from the operation phase (electricity and fuel consumption and emissions related to combustion. Alternatives showed better performance than the existing scenario. Using ReCipe endpoint methodology, and among the three alternatives tested, the anaerobic digestion had the best overall environmental performance. It is recommended to convert to fluid bed incineration if the concerns were more about human health or to anaerobic digestion if the concerns were more about depletion in resources. The endpoint approach may simplify the outcomes of this study as follows: if the plant is converted to fluid bed incineration, it could prevent an average of 43.2 DALYs in human life, save 0.059 species in the area

  5. APPLYING LCC METHODOLOGY FOR THE EVALUATION OF THE EFFECTIVENESS OF AN INVESTMENT OF PROJECTS OF THE SEWAGE TREATMENT PLANT

    Directory of Open Access Journals (Sweden)

    Anatoli Hurynovich

    2016-06-01

    Full Text Available The article is referring to the current problems of the evaluation of the effectiveness of an investment of new plans and of the modernization of existing sewage treatment plants including aspects of the optimization of costs of the sewage treatment. He shows the modernization of the sewage treatment plant the Evaluation of the life cycle as the adequate tool assisting choice of the best variant or the level. He is presenting characteristics of LCС methodology and examples of using to the technology assessment the sewage treatment.

  6. [The methodological basis of expert assessment of unfavourable outcomes of the stomatological treatment in the framework of civil law proceedings].

    Science.gov (United States)

    Pigolkin, Iu I; Murzova, T V; Mirzoev, Kh M

    2011-01-01

    The authors discuss peculiarities of the performance of forensic medical expertise in the cases of unfavourable outcomes of the stomatological treatment. The methodological basis of expert assessment has been created to be applied in situations related to the unfavourable outcomes of dental care.

  7. Assessment of clinical practice guideline methodology for the treatment of knee osteoarthritis with intra-articular hyaluronic acid.

    Science.gov (United States)

    Altman, Roy D; Schemitsch, Emil; Bedi, Asheesh

    2015-10-01

    Clinical practice guidelines are of increasing importance in the decision making for the treatment of knee osteoarthritis. Inconsistent recommendations regarding the use of intra-articular hyaluronic acid for the treatment of knee osteoarthritis have led to confusion among treating physicians. Literature search to identify clinical practice guidelines that provide recommendations regarding the use of intra-articular hyaluronic acid treatment for knee osteoarthritis was conducted. Included guidelines were appraised using the AGREE II instrument. Guideline development methodologies, how the results were assessed, the recommendation formation, and work group composition were summarized. Overall, 10 clinical practice guidelines were identified that met our inclusion criteria. AGREE II domain scores were variable across the included guidelines. The methodology utilized across the guidelines was heterogeneous regarding the evidence inclusion criteria, analysis of evidence results, formulation of clinical practice recommendations, and work group composition. The recommendations provided by the guidelines for intra-articular hyaluronic acid treatment for knee osteoarthritis are highly inconsistent as a result of the variability in guideline methodology. Overall, 30% of the included guidelines recommended against the use of intra-articular hyaluronic acid in the treatment of knee osteoarthritis, while 30% deemed the treatment an appropriate intervention under certain scenarios. The remaining 40% of the guidelines provided either an uncertain recommendation or no recommendation at all, based on the high variability in reviewed evidence regarding efficacy and trial quality. There is a need for a standard "appropriate methodology" that is agreed upon for osteoarthritis clinical practice guidelines in order to prevent the development of conflicting recommendations for intra-articular hyaluronic acid treatment for knee osteoarthritis, and to assure that treating physicians who

  8. Scientific-methodological approaches to designing risk-oriented model of control and surveillance activities in the sphere of consumer rights protection

    Directory of Open Access Journals (Sweden)

    N.V. Zaitseva

    2017-06-01

    Full Text Available We present scientific-methodological approaches to defining risk categories of economic entities which are subject to surveillance in the sphere of consumer rights protection. Risk is suggested to be assessed as a product of violations frequency comprising violations of separate provisions of the law on consumer rights protection detected in the course of scheduled and unscheduled inspections; a number of claims per one detected violation which were satisfied by courts in favor of consumers; each separate case of harm accepted by court in money terms (as a sum of physical and moral damage to health and damage to property; and coefficient of a potential impact scope which differentiates risks for economic entities belonging to micro-, small, medium-sized and large business. Our information sources are official statistic data obtained due to realization of state control in the sphere of consumer rights protection and court practice collected in all the RF regions over 2012–2016. It is shown that a share of economic entities with extremely high risk potential which can cause total material damage to consumers in sums greater than 10 million rubles per year amounts to about 0.15 % of the total number of economic entities (both juridical persons and private entrepreneurs; economic entities with high risk potential account for about 2 %. Such groups are made of companies involved in financial markets, share construction services, insurance and tourism. About 23 % of juridical persons and private entrepreneurs can be classified as having low risk potential and they can be excluded from scheduled inspections. Economic entities structure in general corresponds to world practices. It is shown that risk-oriented surveillance model development requires improvements in keeping registers of juridical persons and private entrepreneurs as such registers should contain comprehensive information; it is necessary for correct risk category (or hazard category

  9. Empirical Comparison of Two Psychological Therapies: Self Psychology and Cognitive Orientation in the Treatment of Anorexia and Bulimia

    Science.gov (United States)

    Bachar, Eytan; Latzer, Yael; Kreitler, Shulamit; Berry, Elliot M.

    1999-01-01

    The authors investigated the applicability of self psychological treatment (SPT) and cognitive orientation treatment (COT) to the treatment of anorexia and bulimia. Thirty-three patients participated in this study. The bulimic patients (n = 25) were randomly assigned either to SPT, COT, or control/nutritional counseling only (C/NC). The anorexic patients (n = 8) were randomly assigned to either SPT or COT. Patients were administered a battery of outcome measures assessing eating disorders symptomatology, attitudes toward food, self structure, and general psychiatric symptoms. After SPT, significant improvement was observed. After COT, slight but nonsignificant improvement was observed. After C/NC, almost no changes could be detected.(The Journal of Psychotherapy Practice and Research 1999; 8:115–128) PMID:10079459

  10. Effect of post-treatment on photocatalytic oxidation activity of (111 oriented NaNbO3 film

    Directory of Open Access Journals (Sweden)

    Feng Zhang

    2015-10-01

    Full Text Available We investigate the impact of post-treatment on photocatalytic oxidation activity of (111 oriented NaNbO3 film prepared by pulse laser deposition. Some impurities such as Na2Nb4O11 and bigger particles appear in the treated samples. The activity of rhodamine B degradation with N2 purge increases with the amount of ⋅OH, the sample treated under H2/Ar(7% being the highest activity, followed by under air and untreated one; the opposite trend is observed when the system was without N2 purge.

  11. Sexual orientation differences in treatment expectation, alliance, and outcome among patients at risk for suicide in a public psychiatric hospital.

    Science.gov (United States)

    Plöderl, Martin; Kunrath, Sabine; Cramer, Robert J; Wang, Jen; Hauer, Larissa; Fartacek, Clemens

    2017-05-15

    Sexual minority (SM) individuals (gay, lesbian, bisexual, or otherwise nonheterosexual) are at increased risk for mental disorders and suicide and adequate mental healthcare may be life-saving. However, SM patients experience barriers in mental healthcare that have been attributed to the lack of SM-specific competencies and heterosexist attitudes and behaviors on the part of mental health professionals. Such barriers could have a negative impact on common treatment factors such as treatment expectancy or therapeutic alliance, culminating in poorer treatment outcomes for SM versus heterosexual patients. Actual empirical data from general psychiatric settings is lacking, however. Thus, comparing the treatment outcome of heterosexual and SM patients at risk for suicide was the primary aim of this study. The secondary aim was to compare treatment expectation and working alliance as two common factors. We report on 633 patients from a suicide prevention inpatient department within a public psychiatric hospital. Most patients were at risk for suicide due to a recent suicide attempt or warning signs for suicide, usually in the context of a severe psychiatric disorder. At least one indicator of SM status was reported by 21% of patients. We assessed the treatment outcome by calculating the quantitative change in suicide ideation, hopelessness, and depression. We also ran related treatment responder analyses. Treatment expectation and working alliance were the assessed common factors. Contrary to the primary hypothesis, SM and heterosexual patients were comparable in their improvement in suicide ideation, hopelessness, or depression, both quantitatively and in treatment responder analysis. Contrary to the secondary hypothesis, there were no significant sexual orientation differences in treatment expectation and working alliance. When adjusting for sociodemographics, diagnosis, and length of stay, some sexual orientation differences became significant, indicating that SM

  12. Automated selection of beam orientations and segmented intensity-modulated radiotherapy (IMRT) for treatment of oesophagus tumors

    International Nuclear Information System (INIS)

    Woudstra, Evert; Heijmen, Ben J.M.; Storchi, Pascal R.M.

    2005-01-01

    Background and purpose: For some treatment sites, there is evidence in the literature that five to nine equiangular input beam directions are enough for generating IMRT plans. For oesophagus cancer, there is a report showing that going from four to nine beams may even result in lower quality plans. In this paper, our previously published algorithm for automated beam angle selection (Cycle) has been extended to include segmented IMRT. For oesophagus cancer patients, we have investigated whether automated orientation selection from a large number of equiangular input beam directions (up to thirty-six) for IMRT optimisation can result in improved lung sparing. Materials and methods: CT-data from five oesophagus patients treated recently in our institute were used for this study. For a prescribed mean PTV dose of 55 Gy, Cycle was used in an iterative procedure to minimise the mean lung dose under the following hard constraints: standard deviation for PTV dose inhomogeneity 2% (1,1 Gy), maximum spinal cord dose 45 Gy. Conformal radiotherapy (CFRT) and IMRT plans for a standard four field oesophagus beam configuration were compared with IMRT plans generated by automated selection from nine or thirty-six equiangular input beam orientations. Comparisons were also made with dose distributions generated with our commercial treatment planning system (TPS), and with observations in the literature. Results: Using Cycle, automated orientation selection from nine or thirty-six input beam directions resulted in improved lung sparing compared to the four field set-ups. Compared to selection from nine input orientations, selection from thirty-six directions did always result in lower mean lung doses, sometimes with even fewer non-zero weight beams. On average only seven beams with a non-zero weight were enough for obtaining the lowest mean lung dose, yielding clinically feasible plans even in case of thirty-six input directions for the optimisation process. With our commercial TPS

  13. Influence of gender, sexual orientation, and need on treatment utilization for substance use and mental disorders: Findings from the California Quality of Life Survey

    OpenAIRE

    Mays Vickie M; Greenwell Lisa; Grella Christine E; Cochran Susan D

    2009-01-01

    Abstract Background Prior research has shown a higher prevalence of substance use and mental disorders among sexual minorities, however, the influence of sexual orientation on treatment seeking has not been widely studied. We use a model of help-seeking for vulnerable populations to investigate factors related to treatment for alcohol or drug use disorders and mental health disorders, focusing on the contributions of gender, sexual orientation, and need. Methods Survey data were obtained from...

  14. Habit Reversal Treatment of Tic Disorders: A Methodological Critique of the Literature

    Science.gov (United States)

    Carr, James E.; Chong, Ivy M.

    2005-01-01

    One of the most commonly reported and successful behavioral interventions for tic disorders is habit reversal (HR). Several narrative literature reviews have adequately summarized the outcomes of these studies. The purpose of this article was to review studies that used HR to treat tics in terms of their methodological characteristics and rigor.…

  15. WE-H-BRC-04: Implement Lean Methodology to Make Our Current Process of CT Simulation to Treatment More Efficient

    Energy Technology Data Exchange (ETDEWEB)

    Boddu, S; Morrow, A; Krishnamurthy, N; McVicker, A; Deb, N; Rangaraj, D [Scott & White Hospital, Temple, TX (United States)

    2016-06-15

    Purpose: Our goal is to implement lean methodology to make our current process of CT simulation to treatment more efficient. Methods: In this study, we implemented lean methodology and tools and employed flowchart in excel for process-mapping. We formed a group of physicians, physicists, dosimetrists, therapists and a clinical physics assistant and huddled bi-weekly to map current value streams. We performed GEMBA walks and observed current processes from scheduling patient CT Simulations to treatment plan approval. From this, the entire workflow was categorized into processes, sub-processes, and tasks. For each process we gathered data on touch time, first time quality, undesirable effects (UDEs), and wait-times from relevant members of each task. UDEs were binned per frequency of their occurrence. We huddled to map future state and to find solutions to high frequency UDEs. We implemented visual controls, hard stops, and documented issues found during chart checks prior to treatment plan approval. Results: We have identified approximately 64 UDEs in our current workflow that could cause delays, re-work, compromise the quality and safety of patient treatments, or cause wait times between 1 – 6 days. While some UDEs are unavoidable, such as re-planning due to patient weight loss, eliminating avoidable UDEs is our goal. In 2015, we found 399 issues with patient treatment plans, of which 261, 95 and 43 were low, medium and high severity, respectively. We also mapped patient-specific QA processes for IMRT/Rapid Arc and SRS/SBRT, involving 10 and 18 steps, respectively. From these, 13 UDEs were found and 5 were addressed that solved 20% of issues. Conclusion: We have successfully implemented lean methodology and tools. We are further mapping treatment site specific workflows to identify bottlenecks, potential breakdowns and personnel allocation and employ tools like failure mode effects analysis to mitigate risk factors to make this process efficient.

  16. WE-H-BRC-04: Implement Lean Methodology to Make Our Current Process of CT Simulation to Treatment More Efficient

    International Nuclear Information System (INIS)

    Boddu, S; Morrow, A; Krishnamurthy, N; McVicker, A; Deb, N; Rangaraj, D

    2016-01-01

    Purpose: Our goal is to implement lean methodology to make our current process of CT simulation to treatment more efficient. Methods: In this study, we implemented lean methodology and tools and employed flowchart in excel for process-mapping. We formed a group of physicians, physicists, dosimetrists, therapists and a clinical physics assistant and huddled bi-weekly to map current value streams. We performed GEMBA walks and observed current processes from scheduling patient CT Simulations to treatment plan approval. From this, the entire workflow was categorized into processes, sub-processes, and tasks. For each process we gathered data on touch time, first time quality, undesirable effects (UDEs), and wait-times from relevant members of each task. UDEs were binned per frequency of their occurrence. We huddled to map future state and to find solutions to high frequency UDEs. We implemented visual controls, hard stops, and documented issues found during chart checks prior to treatment plan approval. Results: We have identified approximately 64 UDEs in our current workflow that could cause delays, re-work, compromise the quality and safety of patient treatments, or cause wait times between 1 – 6 days. While some UDEs are unavoidable, such as re-planning due to patient weight loss, eliminating avoidable UDEs is our goal. In 2015, we found 399 issues with patient treatment plans, of which 261, 95 and 43 were low, medium and high severity, respectively. We also mapped patient-specific QA processes for IMRT/Rapid Arc and SRS/SBRT, involving 10 and 18 steps, respectively. From these, 13 UDEs were found and 5 were addressed that solved 20% of issues. Conclusion: We have successfully implemented lean methodology and tools. We are further mapping treatment site specific workflows to identify bottlenecks, potential breakdowns and personnel allocation and employ tools like failure mode effects analysis to mitigate risk factors to make this process efficient.

  17. Sexual orientation, treatment utilization, and barriers for alcohol related problems: Findings from a nationally representative sample.

    Science.gov (United States)

    Allen, Junior Lloyd; Mowbray, Orion

    2016-04-01

    Gay, lesbian, and bisexual (GLB) individuals appear to have an increased likelihood of alcohol use disorders and treatment utilization for alcohol related problems compared to heterosexual individuals. Despite this increase, treatment utilization rates among GLB individuals remain low. In an effort to address this, our paper examined whether or not GLB individuals encounter unique barriers when pursuing treatment for alcohol related problems. Using data from the National Epidemiologic Survey on Alcohol Related Conditions (NESARC), we examined service sector specific factors, some of which included (a) utilization rates, (b) self-reported treatment barriers, and (c) whether or not there were emergent differences among GLB individuals, after controlling for socio-demographic and clinical characteristics. Findings indicated that GLB individuals reported higher severity rates for alcohol use disorders when compared to heterosexual individuals, and were significantly more likely to utilize treatment services for alcohol related problems, however, not across all treatment sectors. While similar patterns were observed when examining barriers to treatment, bisexual individuals reported significantly more barriers than heterosexual and gay/lesbian individuals. These findings underscored the importance of identifying and developing interventions that addresses treatment barriers associated with alcohol use service utilization among GLB populations, and creating improved outreach and education programs to better address stigmas associated with substance use and sexuality. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  18. Content and Methodological Formation Model of a Younger Pupil Value-Oriented Attitude to Reality Based on Historical and Social Science Knowledge

    Science.gov (United States)

    Zakirova, Ranija R.; Shamigulova, Oksana ?.

    2016-01-01

    One of the most important functions of historical and pedagogical education in modern educational the system is connected with a pupil's character features development, a value apprehension of social events and a formation of a value-oriented attitude to reality. The main aim of the present article is to describe and analyze the results of a…

  19. A family-oriented treatment program for youths with ketamine abuse and their caregivers: a pilot study in Taiwan

    Directory of Open Access Journals (Sweden)

    Wang LJ

    2015-07-01

    Full Text Available Liang-Jen Wang,1 Shing-Fang Lu,1 Wen-Jiun Chou,1 Mian-Yoon Chong,2 Yao-Hsing Wang,1 Yu-Lian Hsieh,1 Yi-Hsuan Lee,1 Ching Chen2 1Department of Child and Adolescent Psychiatry, 2Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan Objective: The abuse of ketamine by youths has grown into a serious public health issue. However, a reliable and efficient treatment has still not been found for youths who abuse ketamine. This pilot study investigated the effects of a family-oriented treatment program for ketamine-using youths and their caregivers.Methods: To carry out this study, 42 youths with ketamine use (mean age 16.6±1.1 years who were referred to take part in a 10-week treatment program based on motivational enhancement principles were selected, as were their principal caregivers (mean age 46.4±7.1 years, who were similarly referred to take part in a 10-week training program for parenting skills. The study had the youths complete the Chinese Craving Beliefs Questionnaire, the Adolescents’ Behavior problem Scale, and the Family APGAR both immediately before and after the program. Likewise, the youths’ caregivers completed the Family APGAR, the 12-item version of the Chinese Health Questionnaire, and the Parenting Stress Index.Results: Of the 42 youth–caregiver pairs that took part in this study, 37 (88% completed the 10-week program and both sets of assessments. After the treatment, the participating youths’ substance cravings declined (t=3.88, P<0.001, while family function, as perceived by the participating caregivers, significantly increased (t=2.22, P=0.033. The improvement in caregivers’ perceptions of family function were positively related to the improvement of the caregivers’ health status (r=-0.36, P=0.022.Conclusion: According to its results, this pilot study submits that family-oriented treatment programs may be considered a potentially effective

  20. A new general methodology for incorporating physico-chemical transformations into multi-phase wastewater treatment process models.

    Science.gov (United States)

    Lizarralde, I; Fernández-Arévalo, T; Brouckaert, C; Vanrolleghem, P; Ikumi, D S; Ekama, G A; Ayesa, E; Grau, P

    2015-05-01

    This paper introduces a new general methodology for incorporating physico-chemical and chemical transformations into multi-phase wastewater treatment process models in a systematic and rigorous way under a Plant-Wide modelling (PWM) framework. The methodology presented in this paper requires the selection of the relevant biochemical, chemical and physico-chemical transformations taking place and the definition of the mass transport for the co-existing phases. As an example a mathematical model has been constructed to describe a system for biological COD, nitrogen and phosphorus removal, liquid-gas transfer, precipitation processes, and chemical reactions. The capability of the model has been tested by comparing simulated and experimental results for a nutrient removal system with sludge digestion. Finally, a scenario analysis has been undertaken to show the potential of the obtained mathematical model to study phosphorus recovery. Copyright © 2015 Elsevier Ltd. All rights reserved.

  1. Current state of methodological and decisions for radiation treatment of blood, its components and products

    Directory of Open Access Journals (Sweden)

    Gordeev A.V.

    2014-12-01

    Full Text Available This article presents currently used blood transfusion media — components and blood products, therapeutic effects, reactions and complications of blood transfusion, use of radiation treatment for blood transfusion fluids. There had been discussed in detail the practice of radiation processing of blood components and for the prevention of reaction "graft versus host" and studies of plasma radiation treatment for its infectious safety. There was presented the current state of techniques and technical solutions of radiation treatment of transfusion-transmissible environments. There were also considered an alternative to radiation treatment of blood.

  2. Analysis of structural heterogeneities on drilled cores: a reservoir modeling oriented methodology; Analyse des heterogeneites structurales sur carottes: une methodologie axee vers la modelisation des reservoirs

    Energy Technology Data Exchange (ETDEWEB)

    Cortes, P.; Petit, J.P. [Montpellier-2 Univ., Lab. de Geophysique, Tectonique et Sedimentologie, UMR CNRS 5573, 34 (France); Guy, L. [ELF Aquitaine Production, 64 - Pau (France); Thiry-Bastien, Ph. [Lyon-1 Univ., 69 (France)

    1999-07-01

    The characterization of structural heterogeneities of reservoirs is of prime importance for hydrocarbons recovery. A methodology is presented which allows to compare the dynamic behaviour of fractured reservoirs and the observation of microstructures on drilled cores or surface reservoir analogues. (J.S.)

  3. Methodological challenges in indirect treatment comparisons: spotlight on a recent comparison of long-acting injectable aripiprazole versus paliperidone palmitate in the treatment of schizophrenia.

    Science.gov (United States)

    Singh, Arun; Gopal, Srihari; Kim, Edward; Mathews, Maju; Kern-Sliwa, Jennifer; Turkoz, Ibrahim; Wooller, Annette; Berlin, Jesse

    2018-03-01

    In a recent study, an indirect treatment comparison was performed to examine the relative efficacy and tolerability of aripiprazole once monthly and paliperidone palmitate once monthly. The authors concluded that the results may suggest relative advantages for aripiprazole once monthly over paliperidone palmitate once monthly in the short-term treatment of schizophrenia. However, the validity of the study is compromised as an indirect treatment comparison using extant data may violate important assumptions. Other methodological issues identified further highlight the challenges of performing indirect treatment comparisons.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/.

  4. Treatment of Chemotherapy-Induced Peripheral Neuropathy in Integrative Oncology: A Survey of Acupuncture and Oriental Medicine Practitioners.

    Science.gov (United States)

    Lu, Zhaoxue; Moody, Jennifer; Marx, Benjamin L; Hammerstrom, Tracy

    2017-12-01

    Complementary and alternative medicine is increasingly integrated into cancer care. We sought detail on the treatment of chemotherapy-induced peripheral neuropathy (CIPN) with acupuncture and oriental medicine (AOM) by surveying practitioners at integrative oncology (IO) sites across the United States. Online survey of licensed acupuncturists. IO sites in the United States. Fifteen licensed acupuncturists who completed the survey between February 2014 and June 2014. Demographics, IO setting characteristics, AOM treatment characteristics, and practitioner-reported outcomes. Respondents reported an average of 31.3 ± 17.2 patients per week, and one-third (10.1 mean; 7.2 standard deviation [SD]) were treated for CIPN. Medical doctors (86.7%) were the most common providers with whom respondents worked. Traditional Chinese medicine style acupuncture was utilized by a majority of respondents (86.7%), and the most commonly used points were local, typically in the hands and feet, such as Ba Feng, Ba Xie, LV3, and LI4. In addition to acupuncture, nutritional advice was the most frequent auxiliary modality provided by respondents (85.7%). On average, respondents provided 12.75 ± 4.17 treatments for CIPN patients, and a majority (53%) reported treating patients once per week. Timing of the treatments relative to chemotherapy infusion was evenly distributed between "1-2 days after infusion" (60%), "at time of infusion" (53.3%), and "1-2 days before infusion" (46.7%). Sixty percent of respondents rated outcomes as "moderately successful with moderate improvement seen." This survey provides detail regarding IO sites using acupuncture for CIPN as well as real-world treatment patterns, including common point combinations, visit characteristics, and practitioner-reported outcomes. This information contributes to the emerging evidence on the use of acupuncture to address unmet needs of CIPN patients, and supports the development of best practice guidelines for the treatment

  5. Orientation of handle for successful prosthetic treatment in patients with an anatomic compromise after a maxillectomy.

    Science.gov (United States)

    Sumita, Yuka I; Hattori, Mariko; Elbashti, Mahmoud E; Taniguchi, Hisashi

    2017-05-01

    This clinical technique provides a key procedure for successful prosthetic treatment in patients with an anatomical compromise after a maxillectomy. When making a preliminary impression, the clinician must keep the handle of the stock tray parallel to the patient's interpupillary line extraorally to maintain the correct position of the tray and to make a record of the inclination of the occlusal plane. This simple consideration during this first step of making a preliminary impression can be an important guide for both dentists and dental technicians. Information about the correct positioning of the tray and the inclination of the occlusal plane obtained by using a stock tray handle will greatly reduce the stress experienced by dentists, dental technicians, and patients during the fabrication of the prosthesis and will ultimately lead to successful prosthetic treatment in patients with anatomic compromise resulting from a maxillectomy. Copyright © 2016 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

  6. The effect of an attachment-oriented couple intervention for breast cancer patients and partners in the early treatment phase

    DEFF Research Database (Denmark)

    Nicolaisen, Anne; Hagedoorn, Mariët; Hansen, Dorte Gilså

    2018-01-01

    OBJECTIVE: Patients and partners both cope individually and as a dyad with challenges related to a breast cancer diagnosis. The objective of this study was to evaluate the effect of a psychological attachment-oriented couple intervention for breast cancer patients and partners in the early...... treatment phase. METHODS: A randomised controlled trial including 198 recently diagnosed breast cancer patients and their partners. Couples were randomised to the Hand in Hand (HiH) intervention in addition to usual care or to usual care only. Self-report assessments were conducted for both patients...... and partners at baseline, post-intervention (5 months) and follow-up (10 months), assessing cancer-related distress, symptoms of anxiety and depression, and dyadic adjustment. Patients' cancer-related distress was the primary outcome. RESULTS: Cancer-related distress decreased over time in both patients...

  7. Deployment Evaluation Methodology for the Electrometallurgical Treatment of DOE-EM Spent Nuclear Fuel

    International Nuclear Information System (INIS)

    Ramer, Ronald James; Adams, James Paul; Rynearson, Michael Ardel; Dahl, Christian Adam

    1999-01-01

    The Department of Energy - Environmental Management (DOE-EM) National Spent Nuclear Fuel Program (NSNFP) is charged with the disposition of legacy Spent Nuclear Fuel (SNF). The NSNFP, conducted by Lockheed Martin Idaho Technology Co. (LMITCO) at the Idaho National Engineering and Environmental Laboratory (INEEL), is evaluating final disposition of SNF in the DOE complex. While direct repository disposal of the SNF is the preferred disposition option, some DOE SNF may need treatment to meet acceptance criteria at various disposition sites. Evaluations of treatment needs and options have been previously prepared, and further evaluations are ongoing activities in the DOE-EM NSNFP. The treatments may range from electrometallurgical treatment (EMT) and chemical dissolution to engineering controls. As a planning basis, a need is assumed for a treatment process, either as a primary or backup technology, that is compatible with, and cost-effective for, this portion of the DOE-EM inventory. The current planning option for treating this SNF, pending completion of development work and National Environmental Policy Act (NEPA) analysis, is the EMT process under development by Argonne National Laboratory - West (ANL-W). A decision on the deployment of the EMT is pending completion of an engineering scale demonstration currently in progress at ANL-W. Treatment options and treatment locations will depend on fuel type and location of the fuel. One of the first steps associated with selecting one or more sites for treating SNF in the DOE complex is to determine the cost of each option. An economic analysis will assist in determining which fuel treatment alternative attains the optimum disposition of SNF at the lowest possible cost to the government and the public. One of the major issues associated with SNF treatment is final disposition of treatment products and associated waste streams. During conventional SNF treatment, various chemicals are added that may increase the product

  8. Optimization-based methodology for wastewater treatment plant synthesis – a full scale retrofitting case study

    DEFF Research Database (Denmark)

    Bozkurt, Hande; Gernaey, Krist; Sin, Gürkan

    2015-01-01

    Existing wastewater treatment plants (WWTP) need retrofitting in order to better handle changes in the wastewater flow and composition, reduce operational costs as well as meet newer and stricter regulatory standards on the effluent discharge limits. In this study, we use an optimization based...... technologies. The superstructure optimization problem is formulated as a Mixed Integer (non)Linear Programming problem and solved for different scenarios - represented by different objective functions and constraint definitions. A full-scale domestic wastewater treatment plant (265,000 PE) is used as a case...... framework to manage the multi-criteria WWTP design/retrofit problem for domestic wastewater treatment. The design space (i.e. alternative treatment technologies) is represented in a superstructure, which is coupled with a database containing data for both performance and economics of the novel alternative...

  9. Current state of methodological and decisions for radiation treatment of blood, its components and products

    OpenAIRE

    Gordeev A.V.; Naumova L.A.; Kharitonov S.V.

    2014-01-01

    This article presents currently used blood transfusion media — components and blood products, therapeutic effects, reactions and complications of blood transfusion, use of radiation treatment for blood transfusion fluids. There had been discussed in detail the practice of radiation processing of blood components and for the prevention of reaction "graft versus host" and studies of plasma radiation treatment for its infectious safety. There was presented the current state of techniques and tec...

  10. Deployment Evaluation Methodology for the Electrometallurgical Treatment of DOE-EM Spent Nuclear Fuel

    International Nuclear Information System (INIS)

    Dahl, C.A.; Adams, J.P.; Rynearson, M.A.; Ramer, R.J.

    1999-01-01

    The Department of Energy - Environmental Management (DOE-EM) National Spent Nuclear Fuel Program (NSNFP) is charged with the disposition of legacy spent nuclear fuel (SNF). While direct repository disposal of the SNF is the preferred disposition option, some DOE SNF may need treatment to meet acceptance criteria at various disposition sites. The treatments may range from electrometallurgical treatment (EMT) and chemical dissolution to engineering controls. As a planning basis, a need is assumed for a treatment process, either as a primary or backup technology, that is compatible with, and cost-effective for, this portion of the DOE-EM inventory. The current planning option for treating this SNF, pending completion of development work and National Environmental Policy Act (NEPA) analysis, is the EMT process under development by Argonne National Laboratory - West (ANL-W). A decision on the deployment of the EMT is pending completion of an engineering scale demonstration currently in progress at ANL-W. For this study, a set of questions was developed for the EMT process for fuels at several locations. The set of questions addresses all issues associated with design, construction, and operation of a production facility. A matrix table was developed to determine questions applicable to various fuel treatment options. A work breakdown structure (WBS) was developed to identify a treatment process and costs from initial design to shipment of treatment products to final disposition. Costs were applied to determine the life-cycle cost of each option. This technique can also be applied to other treatment techniques for treating SNF

  11. Optimizing Oily Wastewater Treatment Via Wet Peroxide Oxidation Using Response Surface Methodology

    International Nuclear Information System (INIS)

    Shi, Jianzhong; Wang, Xiuqing; Wang, Xiaoyin

    2014-01-01

    The process of petroleum involves in a large amount of oily wastewater that contains high levels of chemical oxygen demand (COD) and toxic compounds. So they must be treated before their discharge into the receptor medium. In this paper, wet peroxide oxidation (WPO) was adopted to treat the oily wastewater. Central composite design, an experimental design for response surface methodology (RSM), was used to create a set of 31 experimental runs needed for optimizing of the operating conditions. Quadratic regression models with estimated coefficients were developed to describe the COD removals. The experimental results show that WPO could effectively reduce COD by 96.8% at the optimum conditions of temperature 290 .deg. C, H 2 O 2 excess (HE) 0.8, the initial concentration of oily wastewater 3855 mg/L and reaction time 9 min. RSM could be effectively adopted to optimize the operating multifactors in complex WPO process

  12. Assessing a Methodological Proposal for the Design, Creation and Evaluation of Learning Objects Oriented to Educators with Diverse Educational and Technological Competencies

    Directory of Open Access Journals (Sweden)

    Jorge J. Maldonado

    2016-04-01

    Full Text Available This paper describes a methodological proposal for the design, creation and evaluation of Learning Objects (LOs. This study arises from the compilation and analysis of several LO design methodologies currently used in Ibero-America. This proposal, which has been named DICREVOA, defines five different phases: analysis, design (instructional and multimedia, implementation (LO and metadata, evaluation (from the perspective of both the producer and the consumer of the LO, and publishing. The methodology focuses not only on the teaching inexperienced, but also on those having a basic understanding of the technological and educational aspects related to LO design; therefore, the study emphasizes LO design activities centered around the Kolb cycle and the use of the ExeLearning tool in order to implement the LO core. Additionally, DICREVOA was used in a case study, which demonstrates how it provides a feasible mechanism for LO design and implementation withindifferent contexts. Finally, DICREVOA, the case study to which it was applied, and the results obtained are presented.

  13. HIV Risks, Testing, and Treatment in the Former Soviet Union: Challenges and Future Directions in Research and Methodology.

    Science.gov (United States)

    Saadat, Victoria M

    2015-01-01

    The dissolution of the USSR resulted in independence for constituent republics but left them battling an unstable economic environment and healthcare. Increases in injection drug use, prostitution, and migration were all widespread responses to this transition and have contributed to the emergence of an HIV epidemic in the countries of former Soviet Union. Researchers have begun to identify the risks of HIV infection as well as the barriers to HIV testing and treatment in the former Soviet Union. Significant methodological challenges have arisen and need to be addressed. The objective of this review is to determine common threads in HIV research in the former Soviet Union and provide useful recommendations for future research studies. In this systematic review of the literature, Pubmed was searched for English-language studies using the key search terms "HIV", "AIDS", "human immunodeficiency virus", "acquired immune deficiency syndrome", "Central Asia", "Kazakhstan", "Kyrgyzstan", "Uzbekistan", "Tajikistan", "Turkmenistan", "Russia", "Ukraine", "Armenia", "Azerbaijan", and "Georgia". Studies were evaluated against eligibility criteria for inclusion. Thirty-nine studies were identified across the two main topic areas of HIV risk and barriers to testing and treatment, themes subsequently referred to as "risk" and "barriers". Study design was predominantly cross-sectional. The most frequently used sampling methods were peer-to-peer and non-probabilistic sampling. The most frequently reported risks were condom misuse, risky intercourse, and unsafe practices among injection drug users. Common barriers to testing included that testing was inconvenient, and that results would not remain confidential. Frequent barriers to treatment were based on a distrust in the treatment system. The findings of this review reveal methodological limitations that span the existing studies. Small sample size, cross-sectional design, and non-probabilistic sampling methods were frequently

  14. A systematic methodology for the robust quantification of energy efficiency at wastewater treatment plants featuring Data Envelopment Analysis.

    Science.gov (United States)

    Longo, S; Hospido, A; Lema, J M; Mauricio-Iglesias, M

    2018-05-10

    This article examines the potential benefits of using Data Envelopment Analysis (DEA) for conducting energy-efficiency assessment of wastewater treatment plants (WWTPs). WWTPs are characteristically heterogeneous (in size, technology, climate, function …) which limits the correct application of DEA. This paper proposes and describes the Robust Energy Efficiency DEA (REED) in its various stages, a systematic state-of-the-art methodology aimed at including exogenous variables in nonparametric frontier models and especially designed for WWTP operation. In particular, the methodology systematizes the modelling process by presenting an integrated framework for selecting the correct variables and appropriate models, possibly tackling the effect of exogenous factors. As a result, the application of REED improves the quality of the efficiency estimates and hence the significance of benchmarking. For the reader's convenience, this article is presented as a step-by-step guideline to guide the user in the determination of WWTPs energy efficiency from beginning to end. The application and benefits of the developed methodology are demonstrated by a case study related to the comparison of the energy efficiency of a set of 399 WWTPs operating in different countries and under heterogeneous environmental conditions. Copyright © 2018 Elsevier Ltd. All rights reserved.

  15. [Current prevention and treatment strategies for osteoporosis. Fracture-oriented, effective, low side effects and inexpensive].

    Science.gov (United States)

    Bartl, R; Bartl, C

    2015-12-01

    Osteoporosis is still an underdiagnosed and insufficiently therapied widespread disease in Germany. Of the estimated 7 million osteoporosis patients only 1.5 million receive a guideline conform diagnosis and even less receive appropriate treatment. Some 90 % of patients are provided with analgesics but only 10 % receive an effective therapy, although efficacious, well-tested and affordable medications are available. In addition, approximately one half of the patients terminate treatment after only 1 year although according to the results of recent studies the duration of therapy should be at least 3-5 years. In view of the increasing average life expectancy, a consistent management for prevention of fractures associated with osteoporosis is always most important for society, even if only for reasons of costs. Achievement of this target depends on four circumstances: clarification of the origin of osteoporosis and fractures (bone consciousness), prophylaxis of bone loss and fractures (primary prevention), consistent guideline conform diagnostics and therapy (secondary and tertiary prevention) and cooperation of all disciplines in medicine (bone is everybody's business). This article describes the current state of diagnostics (bone density measurement with dual X-ray absorptiometry, FRAX®), prophylaxis of fractures (screening program) and therapy (use of economic and effective medications with low side effects). Novel medications are already undergoing clinical testing and a "healing" of bone reduction with restoration of the normal bone structure is to be expected.

  16. Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis

    NARCIS (Netherlands)

    Waldinger, M. D.; Zwinderman, A. H.; Schweitzer, D. H.; Olivier, B.

    2004-01-01

    The aim of this systematic review and meta-analysis is to evaluate whether the design and methodology of drug-treatment studies of premature ejaculation affect the efficacy outcome differently. Therefore, methodological, design and efficacy data from 79 studies ( 3034 males), published between 1943

  17. Do personality traits predict outcome of psychodynamically oriented psychosomatic inpatient treatment beyond initial symptoms?

    Science.gov (United States)

    Steinert, Christiane; Klein, Susanne; Leweke, Frank; Leichsenring, Falk

    2015-03-01

    Whether personality characteristics have an impact on treatment outcome is an important question in psychotherapy research. One of the most common approaches for the description of personality is the five-factor model of personality. Only few studies investigated whether patient personality as measured with the NEO-Five-Factor Inventory (NEO-FFI, Costa & McCrae [1992b]. Revised NEO-PI-R and NEO-FFI. Professional manual. Odessa, FL: Psychological Assessment Recources) predicts outcome. Results were inconsistent. Studies reporting personality to be predictive of outcome did not control for baseline symptoms, while studies controlling initial symptoms could not support these findings. We hypothesized that after taking into account baseline symptoms, the NEO-FFI would not predict outcome and tested this in a large sample of inpatients at a psychosomatic clinic. Naturalistic, non-controlled study using patients' data for multiple regression analysis to identify predictors of outcome. Data of 254 inpatients suffering primarily from depressive, anxiety, stress, and somatoform disorders were analysed. Personality was assessed at the beginning of therapy. For psychotherapy outcome, changes in anxiety and depression (Hospital Anxiety and Depression Scale; HADS), overall psychopathology (Symptom Checklist-90-R Global Severity Index [GSI]), and interpersonal problems (Inventory of Interpersonal Problems; IIP) were measured. The treatment resulted in significant decreases on all outcome measures corresponding to moderate to large effect sizes (HADS: d = 1.03; GSI: d = 0.90; IIP: d = 0.38). Consistent with our hypothesis, none of the personality domains predicted outcome when baseline symptoms were controlled for. Personality assessment at baseline does not seem to have an added value in the prediction of inpatient psychotherapy outcome beyond initial symptoms. Clinical implications Personality dimensions overlap with symptomatic distress. Rather than serve as predictors of

  18. Response surface methodology for the optimization of sludge solubilization by ultrasonic pre-treatment

    Science.gov (United States)

    Zheng, Mingyue; Zhang, Xiaohui; Lu, Peng; Cao, Qiguang; Yuan, Yuan; Yue, Mingxing; Fu, Yiwei; Wu, Libin

    2018-02-01

    The present study examines the optimization of the ultrasonic pre-treatment conditions with response surface experimental design in terms of sludge disintegration efficiency (solubilisation of organic components). Ultrasonic pre-treatment for the maximum solubilization with residual sludge enhanced the SCOD release. Optimization of the ultrasonic pre-treatment was conducted through a Box-Behnken design (three variables, a total of 17 experiments) to determine the effects of three independent variables (power, residence time and TS) on COD solubilization of sludge. The optimal COD was obtained at 17349.4mg/L, when the power was 534.67W, the time was 10.77, and TS was 2%, while the SE of this condition was 28792J/kg TS.

  19. Methodological quality of meta-analyses on treatments for chronic obstructive pulmonary disease: a cross-sectional study using the AMSTAR (Assessing the Methodological Quality of Systematic Reviews) tool.

    Science.gov (United States)

    Ho, Robin S T; Wu, Xinyin; Yuan, Jinqiu; Liu, Siya; Lai, Xin; Wong, Samuel Y S; Chung, Vincent C H

    2015-01-08

    Meta-analysis (MA) of randomised trials is considered to be one of the best approaches for summarising high-quality evidence on the efficacy and safety of treatments. However, methodological flaws in MAs can reduce the validity of conclusions, subsequently impairing the quality of decision making. To assess the methodological quality of MAs on COPD treatments. A cross-sectional study on MAs of COPD trials. MAs published during 2000-2013 were sampled from the Cochrane Database of Systematic Reviews and Database of Abstracts of Reviews of Effect. Methodological quality was assessed using the validated AMSTAR (Assessing the Methodological Quality of Systematic Reviews) tool. Seventy-nine MAs were sampled. Only 18% considered the scientific quality of primary studies when formulating conclusions and 49% used appropriate meta-analytic methods to combine findings. The problems were particularly acute among MAs on pharmacological treatments. In 48% of MAs the authors did not report conflict of interest. Fifty-eight percent reported harmful effects of treatment. Publication bias was not assessed in 65% of MAs, and only 10% had searched non-English databases. The methodological quality of the included MAs was disappointing. Consideration of scientific quality when formulating conclusions should be made explicit. Future MAs should improve on reporting conflict of interest and harm, assessment of publication bias, prevention of language bias and use of appropriate meta-analytic methods.

  20. Development of a High Performance PES Ultrafiltration Hollow Fiber Membrane for Oily Wastewater Treatment Using Response Surface Methodology

    Directory of Open Access Journals (Sweden)

    Noor Adila Aluwi Shakir

    2015-12-01

    Full Text Available This study attempts to optimize the spinning process used for fabricating hollow fiber membranes using the response surface methodology (RSM. The spinning factors considered for the experimental design are the dope extrusion rate (DER, air gap length (AGL, coagulation bath temperature (CBT, bore fluid ratio (BFR, and post-treatment time (PT whilst the response investigated is rejection. The optimal spinning conditions promising the high rejection performance of polyethersulfone (PES ultrafiltration hollow fiber membranes for oily wastewater treatment are at the dope extrusion rate of 2.13 cm3/min, air gap length of 0 cm, coagulation bath temperature of 30 °C, and bore fluid ratio (NMP/H2O of 0.01/99.99 wt %. This study will ultimately enable the membrane fabricators to produce high-performance membranes that contribute towards the availability of a more sustainable water supply system.

  1. Marrying Step Feed with Secondary Clarifier Improvements to Significantly Increase Peak Wet Weather Treatment Capacity: An Integrated Methodology.

    Science.gov (United States)

    Daigger, Glen T; Siczka, John S; Smith, Thomas F; Frank, David A; McCorquodale, J A

    2017-08-01

      The need to increase the peak wet weather secondary treatment capacity of the City of Akron, Ohio, Water Reclamation Facility (WRF) provided the opportunity to test an integrated methodology for maximizing the peak wet weather secondary treatment capacity of activated sludge systems. An initial investigation, consisting of process modeling of the secondary treatment system and computational fluid dynamics (CFD) analysis of the existing relatively shallow secondary clarifiers (3.3 and 3.7 m sidewater depth in 30.5 m diameter units), indicated that a significant increase in capacity from 416 000 to 684 000 m3/d or more was possible by adding step feed capabilities to the existing bioreactors and upgrading the existing secondary clarifiers. One of the six treatment units at the WRF was modified, and an extensive 2-year testing program was conducted to determine the total peak wet weather secondary treatment capacity achievable. The results demonstrated that a peak wet weather secondary treatment capacity approaching 974 000 m3/d is possible as long as secondary clarifier solids and hydraulic loadings could be separately controlled using the step feed capability provided. Excellent sludge settling characteristics are routinely experienced at the City of Akron WRF, raising concerns that the identified peak wet weather secondary treatment capacity could not be maintained should sludge settling characteristics deteriorate for some reason. Computational fluid dynamics analysis indicated that the impact of the deterioration of sludge settling characteristics could be mitigated and the identified peak wet weather secondary treatment capacity maintained by further use of the step feed capability provided to further reduce secondary clarifier solids loading rates at the identified high surface overflow rates. The results also demonstrated that effluent limits not only for total suspended solids (TSS) and five-day carbonaceous biochemical oxygen demand (cBOD5) could be

  2. New methodology in life cycle impact assessment (LCIA) of waste water treatment

    DEFF Research Database (Denmark)

    Larsen, Henrik Fred; Wenzel, Henrik; Hauschild, Michael Zwicky

    chose among different waste water treatments? Which ones are most beneficial in a holistic perspective? Here, the life cycle assessment (LCA) approach as a decision supporting tool may help because its goal is to allow quantification and direct comparison of characteristics as diverse as energy...

  3. Methodologies, languages and tools

    International Nuclear Information System (INIS)

    Amako, Katsuya

    1994-01-01

    This is a summary of the open-quotes Methodologies, Languages and Toolsclose quotes session in the CHEP'94 conference. All the contributions to methodologies and languages are relevant to the object-oriented approach. Other topics presented are related to various software tools in the down-sized computing environment

  4. Data Centric Development Methodology

    Science.gov (United States)

    Khoury, Fadi E.

    2012-01-01

    Data centric applications, an important effort of software development in large organizations, have been mostly adopting a software methodology, such as a waterfall or Rational Unified Process, as the framework for its development. These methodologies could work on structural, procedural, or object oriented based applications, but fails to capture…

  5. Aspect-Oriented Visualization of the Health Status: An Example in Treatment of Cervical Spine Defect.

    Science.gov (United States)

    Deng, Yihan; Denecke, Kerstin

    2016-01-01

    Clinical data is often captured in unstructured texts and scattered in different health information systems. This complicates the aggregation of information in the process of clinical decision making. However, having a quick overview and an efficient representation of relevant aspects of a patient's health status are crucial for this process. While accessing patient data and perusing clinical documents, relevant details need to be discovered quickly. In this paper, we introduce an approach to visualize relevant information from clinical documents by tag clouds. The conventional tag clouds visualize the content of a document using the terms they are containing shown in different sizes with the size calculated based on the term frequency. Important facts and diagnostic results with low occurrence in a text may be ignored by this naïve method. In this paper, we therefore adapt the conventional tag clouds by information extraction and a guidelines-based classification schema, so that the clinical concerns can be visualized more correctly. The aspects are extracted according to a classification schema developed by clinical experts. We evaluate the approach on a set of radiology reports for cervical spine treatment.

  6. Study on preparation of 166Ho-Chitosan oriented in the treatment of liver cancer

    International Nuclear Information System (INIS)

    Dang Ho Hong Quang; Duong Van Dong; Bui Van Cuong; Nguyen Thanh Binh; Nguyen Thanh Nhan; Nguyen Dinh Lam; Nguyen Thi Thu

    2017-01-01

    This study describes the process for the preparation and quality control of 166 Ho-Chitosan product. The labeling conditions of chitosan with 166 Ho radioisotope were carried out such as the concentration of chitosan, pH, temperature and reaction time to create 166 Ho-Chitosan compositions. Product quality inspection 166 Ho-Chitosan on the criteria as nuclide purity, radiochemical purity, tested for sterility and bacterial endotoxin. The results of survey showed that 166 Ho labeled with chitosan were completed in 1% acetic acid, 3 mCi: 30 mg ratio at pH = 3, marking time at room temperature for 30 minutes. The results of quality test have shown radionuclide purity ≥ 99%, radiochemical purity ≥ 98%, meeting the criteria for the aseptic and bacterial endotoxin according to IV Vietnam pharmacopoeia. From the above mentioned, 166 Ho-Chitosan compositions meet the quality criteria of the radiopharmaceuticals, therefore, it can be used in pre-clinical research and its application in clinical treatment. (author)

  7. Clinically orientated classification incorporating shoulder balance for the surgical treatment of adolescent idiopathic scoliosis.

    Science.gov (United States)

    Elsebaie, H B; Dannawi, Z; Altaf, F; Zaidan, A; Al Mukhtar, M; Shaw, M J; Gibson, A; Noordeen, H

    2016-02-01

    The achievement of shoulder balance is an important measure of successful scoliosis surgery. No previously described classification system has taken shoulder balance into account. We propose a simple classification system for AIS based on two components which include the curve type and shoulder level. Altogether, three curve types have been defined according to the size and location of the curves, each curve pattern is subdivided into type A or B depending on the shoulder level. This classification was tested for interobserver reproducibility and intraobserver reliability. A retrospective analysis of the radiographs of 232 consecutive cases of AIS patients treated surgically between 2005 and 2009 was also performed. Three major types and six subtypes were identified. Type I accounted for 30 %, type II 28 % and type III 42 %. The retrospective analysis showed three patients developed a decompensation that required extension of the fusion. One case developed worsening of shoulder balance requiring further surgery. This classification was tested for interobserver and intraobserver reliability. The mean kappa coefficients for interobserver reproducibility ranged from 0.89 to 0.952, while the mean kappa value for intraobserver reliability was 0.964 indicating a good-to-excellent reliability. The treatment algorithm guides the spinal surgeon to achieve optimal curve correction and postoperative shoulder balance whilst fusing the smallest number of spinal segments. The high interobserver reproducibility and intraobserver reliability makes it an invaluable tool to describe scoliosis curves in everyday clinical practice.

  8. Electrochemical treatment of simulated sugar industrial effluent: Optimization and modeling using a response surface methodology

    Directory of Open Access Journals (Sweden)

    P. Asaithambi

    2016-11-01

    Full Text Available The removal of organic compounds from a simulated sugar industrial effluent was investigated through the electrochemical oxidation technique. Effect of various experimental parameters such as current density, concentration of electrolyte and flow rate in a batch electrochemical reactor was studied on the percentage of COD removal and power consumption. The electrochemical reactor performance was analyzed based on with and without recirculation of the effluent having constant inter-electrodes distance. It was found out that the percentage removal of COD increased with the increase of electrolyte concentration and current density. The maximum percentage removal of COD was achieved at 80.74% at a current density of 5 A/dm2 and 5 g/L of electrolyte concentration in the batch electrochemical reactor. The recirculation electrochemical reactor system parameters like current density, concentration of COD and flow rate were optimized using response surface methodology, while COD removal percents were maximized and power consumption minimized. It has been observed from the present analysis that the predicted values are in good agreement with the experimental data with a correlation coefficient of 0.9888.

  9. A new methodology using mathematical treatment in uranium recovery of slags from U-metal production

    International Nuclear Information System (INIS)

    Ferreto, Helio Fernando Rodrigues; Araujo, Berta Floh de

    1999-01-01

    U 3 Si 2 fuel was developed by the Fuel Cycle Department of IPEN/CNEN - SP in order to provide high density fuel elements for the IEA-R1m swimming pool reactor. Uranium containing magnesium fluoride slags are produced during the reduction of U F 4 to metallic uranium, the first step of U 3 Si 2 production. Since enriched uranium is used and taking in account process economics and environmental impacts, the recovery of uranium from the slags is highly recommended. This work deals with the uranium recovery from magnesium fluoride slag via nitric acid leaching process using a new methodology for the study. A statistical procedure for process optimization was applied using a fractional factorial design at two levels and four variables represented as 2 4-1 . Variance analysis followed by multiple regression was used, setting up a first order polygonal model, as follow: y 92,409 +3,825 x 1 - 0,875 x 3 + 1,65 x 4 - 0,95 x 3 x 4 Standard error 1,04572. This equation represents the variables and the most suitable interactions in the uranium recovery process. By using this equation, one can obtain in advance and without making experiments the values from the process variables for a giving process yield. (author)

  10. Determination of Specific Losses in the Limbs of an Epstein Frame Using a Three Epstein Frame Methodology Applied to Grain Oriented Electrical Steels.

    Science.gov (United States)

    Parent, Guillaume; Penin, Rémi; Lecointe, Jean-Philippe; Brudny, Jean-François; Belgrand, Thierry

    2016-06-04

    An experimental method to characterize the magnetic properties of Grain Oriented Electrical Steel in the rolling direction is proposed in this paper. It relies on the use of three 25 cm Epstein frames combined to generate three test-frames of different lengths. This enables the identification of the effective specific losses of the electrical steel when magnetization is applied along the rolling direction. As a consequence, it evidences the deviation of the loss figures obtained using the standardised Epstein test. The difference in losses is explained by the fact that the described method gives "only" the losses attached to the straight parts. The concept of the magnetic path length as defined by the standard is discussed.

  11. Determination of Specific Losses in the Limbs of an Epstein Frame Using a Three Epstein Frame Methodology Applied to Grain Oriented Electrical Steels

    Directory of Open Access Journals (Sweden)

    Guillaume Parent

    2016-06-01

    Full Text Available An experimental method to characterize the magnetic properties of Grain Oriented Electrical Steel in the rolling direction is proposed in this paper. It relies on the use of three 25 cm Epstein frames combined to generate three test-frames of different lengths. This enables the identification of the effective specific losses of the electrical steel when magnetization is applied along the rolling direction. As a consequence, it evidences the deviation of the loss figures obtained using the standardised Epstein test. The difference in losses is explained by the fact that the described method gives “only” the losses attached to the straight parts. The concept of the magnetic path length as defined by the standard is discussed.

  12. Human computer interactions in next-generation of aircraft smart navigation management systems: task analysis and architecture under an agent-oriented methodological approach.

    Science.gov (United States)

    Canino-Rodríguez, José M; García-Herrero, Jesús; Besada-Portas, Juan; Ravelo-García, Antonio G; Travieso-González, Carlos; Alonso-Hernández, Jesús B

    2015-03-04

    The limited efficiency of current air traffic systems will require a next-generation of Smart Air Traffic System (SATS) that relies on current technological advances. This challenge means a transition toward a new navigation and air-traffic procedures paradigm, where pilots and air traffic controllers perform and coordinate their activities according to new roles and technological supports. The design of new Human-Computer Interactions (HCI) for performing these activities is a key element of SATS. However efforts for developing such tools need to be inspired on a parallel characterization of hypothetical air traffic scenarios compatible with current ones. This paper is focused on airborne HCI into SATS where cockpit inputs came from aircraft navigation systems, surrounding traffic situation, controllers' indications, etc. So the HCI is intended to enhance situation awareness and decision-making through pilot cockpit. This work approach considers SATS as a system distributed on a large-scale with uncertainty in a dynamic environment. Therefore, a multi-agent systems based approach is well suited for modeling such an environment. We demonstrate that current methodologies for designing multi-agent systems are a useful tool to characterize HCI. We specifically illustrate how the selected methodological approach provides enough guidelines to obtain a cockpit HCI design that complies with future SATS specifications.

  13. Human Computer Interactions in Next-Generation of Aircraft Smart Navigation Management Systems: Task Analysis and Architecture under an Agent-Oriented Methodological Approach

    Science.gov (United States)

    Canino-Rodríguez, José M.; García-Herrero, Jesús; Besada-Portas, Juan; Ravelo-García, Antonio G.; Travieso-González, Carlos; Alonso-Hernández, Jesús B.

    2015-01-01

    The limited efficiency of current air traffic systems will require a next-generation of Smart Air Traffic System (SATS) that relies on current technological advances. This challenge means a transition toward a new navigation and air-traffic procedures paradigm, where pilots and air traffic controllers perform and coordinate their activities according to new roles and technological supports. The design of new Human-Computer Interactions (HCI) for performing these activities is a key element of SATS. However efforts for developing such tools need to be inspired on a parallel characterization of hypothetical air traffic scenarios compatible with current ones. This paper is focused on airborne HCI into SATS where cockpit inputs came from aircraft navigation systems, surrounding traffic situation, controllers’ indications, etc. So the HCI is intended to enhance situation awareness and decision-making through pilot cockpit. This work approach considers SATS as a system distributed on a large-scale with uncertainty in a dynamic environment. Therefore, a multi-agent systems based approach is well suited for modeling such an environment. We demonstrate that current methodologies for designing multi-agent systems are a useful tool to characterize HCI. We specifically illustrate how the selected methodological approach provides enough guidelines to obtain a cockpit HCI design that complies with future SATS specifications. PMID:25746092

  14. Human Computer Interactions in Next-Generation of Aircraft Smart Navigation Management Systems: Task Analysis and Architecture under an Agent-Oriented Methodological Approach

    Directory of Open Access Journals (Sweden)

    José M. Canino-Rodríguez

    2015-03-01

    Full Text Available The limited efficiency of current air traffic systems will require a next-generation of Smart Air Traffic System (SATS that relies on current technological advances. This challenge means a transition toward a new navigation and air-traffic procedures paradigm, where pilots and air traffic controllers perform and coordinate their activities according to new roles and technological supports. The design of new Human-Computer Interactions (HCI for performing these activities is a key element of SATS. However efforts for developing such tools need to be inspired on a parallel characterization of hypothetical air traffic scenarios compatible with current ones. This paper is focused on airborne HCI into SATS where cockpit inputs came from aircraft navigation systems, surrounding traffic situation, controllers’ indications, etc. So the HCI is intended to enhance situation awareness and decision-making through pilot cockpit. This work approach considers SATS as a system distributed on a large-scale with uncertainty in a dynamic environment. Therefore, a multi-agent systems based approach is well suited for modeling such an environment. We demonstrate that current methodologies for designing multi-agent systems are a useful tool to characterize HCI. We specifically illustrate how the selected methodological approach provides enough guidelines to obtain a cockpit HCI design that complies with future SATS specifications.

  15. Estimation of waste water treatment plant methane emissions: methodology and results from a short campaign

    Science.gov (United States)

    Yver-Kwok, C. E.; Müller, D.; Caldow, C.; Lebegue, B.; Mønster, J. G.; Rella, C. W.; Scheutz, C.; Schmidt, M.; Ramonet, M.; Warneke, T.; Broquet, G.; Ciais, P.

    2013-10-01

    This paper describes different methods to estimate methane emissions at different scales. These methods are applied to a waste water treatment plant (WWTP) located in Valence, France. We show that Fourier Transform Infrared (FTIR) measurements as well as Cavity Ring Down Spectroscopy (CRDS) can be used to measure emissions from the process to the regional scale. To estimate the total emissions, we investigate a tracer release method (using C2H2) and the Radon tracer method (using 222Rn). For process-scale emissions, both tracer release and chamber techniques were used. We show that the tracer release method is suitable to quantify facility- and some process-scale emissions, while the Radon tracer method encompasses not only the treatment station but also a large area around. Thus the Radon tracer method is more representative of the regional emissions around the city. Uncertainties for each method are described. Applying the methods to CH4 emissions, we find that the main source of emissions of the plant was not identified with certainty during this short campaign, although the primary source of emissions is likely to be from solid sludge. Overall, the waste water treatment plant represents a small part (3%) of the methane emissions of the city of Valence and its surroundings,which is in agreement with the national inventories.

  16. Some recent developments in treatment planning software and methodology for BNCT

    International Nuclear Information System (INIS)

    Nigg, D.W.; Wheeler, F.J.; Wessol, D.E.; Wemple, C.A.; Babcock, R.; Capala, J.

    1996-01-01

    Over the past several years/the Idaho National Engineering Laboratory (INEL) has led the development of a unique, internationally-recognized set of software modules (BNCT rtpe) for computational dosimetry and treatment planning for Boron Neutron Capture Therapy (BNCT). The computational capability represented by this software is essential to the proper administration of all forms of radiotherapy for cancer. Such software addresses the need to perform pretreatment computation and optimization of the radiation dose distribution in the target volume. This permits the achievement of the optimal therapeutic ratio (tumor dose relative to critical normal tissue dose) for each individual patient via a systematic procedure for specifying the appropriate irradiation parameters to be employed for a given treatment. These parameters include angle of therapy beam incidence, beam aperture and shape,and beam intensity as a function of position across the beam front. The INEL software is used for treatment planning in the current series of human glioma trials at Brookhaven National Laboratory (BNL) and has also been licensed for research and developmental purposes to several other BNCT research centers in the US and in Europe

  17. Some recent developments in treatment planning software and methodology for BNCT

    International Nuclear Information System (INIS)

    Nigg, D.W.; Wheeler, F.J.; Wessol, D.E.

    1996-01-01

    Over the past several years the Idaho National Engineering Laboratory (INEL) has led the development of a unique, internationally-recognized set of software modules (BNCT-rtpe) for computational dosimetry and treatment planning for Boron Neutron Capture Therapy (BNCT). The computational capability represented by this software is essential to the proper administration of all forms of radiotherapy for cancer. Such software addresses the need to perform pretreatment computation and optimization of the radiation dose distribution in the target volume. This permits the achievement of the optimal therapeutic ratio (tumor dose relative to critical normal tissue dose) for each individual patient via a systematic procedure for specifying the appropriate irradiation parameters to be employed for a given treatment. These parameters include angle of therapy beam incidence, beam aperture and shape, and beam intensity as a function of position across the beam front. The INEL software is used for treatment planning in the current series of human glioma trials at Brookhaven National Laboratory (BNL) and has also been licensed for research and developmental purposes to several other BNCT research centers in the US and in Europe

  18. UNA METODOLOGÍA PARA EL DISEÑO DE UN CURRÍCULO ORIENTADOA LAS COMPETENCIAS A METHODOLOGY FOR COMPETENCY ORIENTED CURRICULA DESIGN

    Directory of Open Access Journals (Sweden)

    Rodolfo Schmal S

    2008-06-01

    Full Text Available En este artículo se aborda el desafío del diseño de un currículo orientado al logro de competencias. Para ello, se analizó el estado del arte mediante una revisión del concepto de competencia y de los modelos curriculares en este ámbito. De esta revisión no se ha encontrado un método formal que permita construir un currículo orientado a las competencias. Para cubrir esta brecha el presente trabajo propone una metodología cuyo punto de partida es asociar a cada competencia un modulo o una asignatura, asociación que puede ser modificada por restricciones de tiempo y recursos a través de un proceso de refinamientos sucesivos. La metodología propone las siguientes etapas a partir de un perfil profesional específico dado por sus competencias y capacidades asociadas: a identificación de los módulos; b secuenciación de los módulos; c estructuración de los módulos; d revisión de los módulos; e revisión del currículo; y f construcción del syllabus. Bajo esta metodología los módulos que conforman el currículo apuntan a integrar los conocimientos y las habilidades requeridas para el logro de las competencias, antes que a fraccionarlos por disciplina.This article deals with the challenge of designing a competency-based curriculum. For this a revision of the concept of competence was analyzed along with the existing curricula models based on competence. A formal method wasn't found which would have allowed in constructing a competency-based curriculum. In order to solve, this article proposes the methodology with which a first stage is started associating each competence with one module or assignment which perhaps at a later stage could be modified for time and resource restrictions through successive refinement process. Starting from a specific professional profile defined by its competences and associate capacities the methodology proposes: a identification of modules; b module sequencing; c structuring of module; d revision of

  19. Methodology development for radioactive waste treatment of CDTN/BR - liquid low-level radioactive wastes

    International Nuclear Information System (INIS)

    Morais, Carlos Antonio de

    1996-01-01

    The radioactive liquid wastes generated in Nuclear Technology Development Centre (CDTN) were initially treated by precipitation/filtration and then the resulting wet solid wastes were incorporated in cement. These wastes were composed of different chemicals and different radioactivities and were generated by different sectors. The objective of the waste treatment method was to obtain minimum wet solid waste volume and decontamination and minimum operational cost. The composition of the solid wastes were taken into consideration for compatible cementation process. Approximately 5,400 litres of liquid radioactive wastes were treated by this process during 1992-1995. The volume reduction was 1/24 th and contained 20% solids. (author)

  20. Evidence for efficacy of acute treatment of episodic tension-type headache: methodological critique of randomised trials for oral treatments.

    Science.gov (United States)

    Moore, R Andrew; Derry, Sheena; Wiffen, Philip J; Straube, Sebastian; Bendtsen, Lars

    2014-11-01

    The International Headache Society (IHS) provides guidance on the conduct of trials for acute treatment of episodic tension-type headache (TTH), a common disorder with considerable disability. Electronic and other searches identified randomised, double-blind trials of oral drugs treating episodic TTH with moderate or severe pain at baseline, or that tested drugs at first pain onset. The aims were to review methods, quality, and outcomes reported (in particular the IHS-recommended primary efficacy parameter pain-free after 2 hours), and to assess efficacy by meta-analysis. We identified 58 reports: 55 from previous reviews and searches, 2 unpublished reports, and 1 clinical trial report with results. We included 40 reports of 55 randomised trials involving 12,143 patients. Reporting quality was generally good, with potential risk of bias from incomplete outcome reporting and small size; the 23 largest trials involved 82% of patients. Few trials reported IHS outcomes. The number needed to treat values for being pain-free at 2 hours compared with placebo were 8.7 (95% confidence interval [CI] 6.2 to 15) for paracetamol 1000 mg, 8.9 (95% CI 5.9 to 18) for ibuprofen 400mg, and 9.8 (95% CI 5.1 to 146) for ketoprofen 25mg. Lower (better) number needed to treat values were calculated for outcomes of mild or no pain at 2 hours, and patient global assessment. These were similar to values for these drugs in migraine. No other drugs had evaluable results for these patient-centred outcomes. There was no evidence that any one outcome was better than others. The evidence available for treatment efficacy is small in comparison to the size of the clinical problem. Copyright © 2014 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

  1. Treatment of hyperthyroidism with radioactive iodine. Methodological changes and follow-up problems

    International Nuclear Information System (INIS)

    Gibold, C.; Delisle, M.J.; Maes, B.; Vaudrey, C.; Pochard, J.M.

    1988-01-01

    The experience of treatment of hyperthyroidism with radioactive iodine in the Nuclear Medicine department of the J. Godinot Institute, Rheims, from 1967 till 1987, is described. One thousand one hundred and fifty patients (723 with diffuse and 427 with nodular hyperthyroidism) received a total of 1 565 doses. The dosage calculation method was considerably simplified, enabling a patient to be treated in 24 hours. Thyroid gland mass evaluation, initially based on the scintigraphic projection area, is now performed by ultrasonography. The mean total radioactivity administered is 370 ± 320 MBq per patient. All patients are seen on the 8th post-treatment week for clinical examination and hormone control. Seven out of 10 patients are cured with a single dose. Long-term follow-up, based on a computer file, is effected by means of an annual letter sent to patient and to his family doctor, but in spite fo sustained efforts 36 per cent of the patients are lost sight of. The diagnosis of iodine 131-induced hypothyroidism is based on plasma levels of TSH which, since 1984, are measured by the ultrasensitive method. The overall incidence of hypothyroidism is 6.6 per cent in the first year and 3 per cent thereafter. Despite a simplified procedure, the results obtained by the authors are similar to those found in the literature, and the cost-efficiency ratio is excellent [fr

  2. Wastewater Treatment Costs and Outlays in Organic Petrochemicals: Standards Versus Taxes With Methodology Suggestions for Marginal Cost Pricing and Analysis

    Science.gov (United States)

    Thompson, Russell G.; Singleton, F. D., Jr.

    1986-04-01

    With the methodology recommended by Baumol and Oates, comparable estimates of wastewater treatment costs and industry outlays are developed for effluent standard and effluent tax instruments for pollution abatement in five hypothetical organic petrochemicals (olefins) plants. The computational method uses a nonlinear simulation model for wastewater treatment to estimate the system state inputs for linear programming cost estimation, following a practice developed in a National Science Foundation (Research Applied to National Needs) study at the University of Houston and used to estimate Houston Ship Channel pollution abatement costs for the National Commission on Water Quality. Focusing on best practical and best available technology standards, with effluent taxes adjusted to give nearly equal pollution discharges, shows that average daily treatment costs (and the confidence intervals for treatment cost) would always be less for the effluent tax than for the effluent standard approach. However, industry's total outlay for these treatment costs, plus effluent taxes, would always be greater for the effluent tax approach than the total treatment costs would be for the effluent standard approach. Thus the practical necessity of showing smaller outlays as a prerequisite for a policy change toward efficiency dictates the need to link the economics at the microlevel with that at the macrolevel. Aggregation of the plants into a programming modeling basis for individual sectors and for the economy would provide a sound basis for effective policy reform, because the opportunity costs of the salient regulatory policies would be captured. Then, the government's policymakers would have the informational insights necessary to legislate more efficient environmental policies in light of the wealth distribution effects.

  3. Methodologies for pre-validation of biofilters and wetlands for stormwater treatment.

    Directory of Open Access Journals (Sweden)

    Kefeng Zhang

    Full Text Available Water Sensitive Urban Design (WSUD systems are frequently used as part of a stormwater harvesting treatment trains (e.g. biofilters (bio-retentions and rain-gardens and wetlands. However, validation frameworks for such systems do not exist, limiting their adoption for end-uses such as drinking water. The first stage in the validation framework is pre-validation, which prepares information for further validation monitoring.A pre-validation roadmap, consisting of five steps, is suggested in this paper. Detailed methods for investigating target micropollutants in stormwater, and determining challenge conditions for biofilters and wetlands, are provided.A literature review was undertaken to identify and quantify micropollutants in stormwater. MUSIC V5.1 was utilized to simulate the behaviour of the systems based on 30-year rainfall data in three distinct climate zones; outputs were evaluated to identify the threshold of operational variables, including length of dry periods (LDPs and volume of water treated per event.The paper highlights that a number of micropollutants were found in stormwater at levels above various worldwide drinking water guidelines (eight pesticides, benzene, benzo(apyrene, pentachlorophenol, di-(2-ethylhexyl-phthalate and a total of polychlorinated biphenyls. The 95th percentile LDPs was exponentially related to system design area while the 5th percentile length of dry periods remained within short durations (i.e. 2-8 hours. 95th percentile volume of water treated per event was exponentially related to system design area as a percentage of an impervious catchment area.The out-comings of this study show that pre-validation could be completed through a roadmap consisting of a series of steps; this will help in the validation of stormwater treatment systems.

  4. HIV Risks, Testing, and Treatment in the Former Soviet Union: Challenges and Future Directions in Research and Methodology

    Directory of Open Access Journals (Sweden)

    Victoria M. Saadat

    2016-01-01

    Full Text Available Background. The dissolution of the USSR resulted in independence for constituent republics but left them battling an unstable economic environment and healthcare. Increases in injection drug use, prostitution, and migration were all widespread responses to this transition and have contributed to the emergence of an HIV epidemic in the countries of former Soviet Union. Researchers have begun to identify the risks of HIV infection as well as the barriers to HIV testing and treatment in the former Soviet Union. Significant methodological challenges have arisen and need to be addressed. The objective of this review is to determine common threads in HIV research in the former Soviet Union and provide useful recommendations for future research studies.Methods. In this systematic review of the literature, Pubmed was searched for English-language studies using the key search terms “HIV”, “AIDS”, “human immunodeficiency virus”, “acquired immune deficiency syndrome”, “Central Asia”, “Kazakhstan”, “Kyrgyzstan”, “Uzbekistan”, “Tajikistan”, “Turkmenistan”, “Russia”, “Ukraine”, “Armenia”, “Azerbaijan”, and “Georgia”. Studies were evaluated against eligibility criteria for inclusion.Results. Thirty-nine studies were identified across the two main topic areas of HIV risk and barriers to testing and treatment, themes subsequently referred to as “risk” and “barriers”. Study design was predominantly cross-sectional. The most frequently used sampling methods were peer-to-peer and non-probabilistic sampling. The most frequently reported risks were condom misuse, risky intercourse, and unsafe practices among injection drug users.  Common barriers to testing included that testing was inconvenient, and that results would not remain confidential.  Frequent barriers to treatment were based on a distrust in the treatment system. Conclusion. The findings of this review reveal methodological limitations

  5. Nutrition and physical activity programs for obesity treatment (PRONAF study: methodological approach of the project

    Directory of Open Access Journals (Sweden)

    Zapico Augusto G

    2012-12-01

    Full Text Available Abstract Background At present, scientific consensus exists on the multifactorial etiopatogenia of obesity. Both professionals and researchers agree that treatment must also have a multifactorial approach, including diet, physical activity, pharmacology and/or surgical treatment. These two last ones should be reserved for those cases of morbid obesities or in case of failure of the previous ones. The aim of the PRONAF study is to determine what type of exercise combined with caloric restriction is the most appropriate to be included in overweigth and obesity intervention programs, and the aim of this paper is to describe the design and the evaluation methods used to carry out the PRONAF study. Methods/design One-hundred nineteen overweight (46 males and 120 obese (61 males subjects aged 18–50 years were randomly assigned to a strength training group, an endurance training group, a combined strength + endurance training group or a diet and physical activity recommendations group. The intervention period was 22 weeks (in all cases 3 times/wk of training for 22 weeks and 2 weeks for pre and post evaluation. All subjects followed a hypocaloric diet (25-30% less energy intake than the daily energy expenditure estimated by accelerometry. 29–34% of the total energy intake came from fat, 14–20% from protein, and 50–55% from carbohydrates. The mayor outcome variables assesed were, biochemical and inflamatory markers, body composition, energy balance, physical fitness, nutritional habits, genetic profile and quality of life. 180 (75.3% subjects finished the study, with a dropout rate of 24.7%. Dropout reasons included: personal reasons 17 (28.8%, low adherence to exercise 3 (5.1%, low adherence to diet 6 (10.2%, job change 6 (10.2%, and lost interest 27 (45.8%. Discussion Feasibility of the study has been proven, with a low dropout rate which corresponds to the estimated sample size. Transfer of knowledge is foreseen as a spin-off, in order

  6. A methodology to estimate greenhouse gases emissions in Life Cycle Inventories of wastewater treatment plants

    International Nuclear Information System (INIS)

    Rodriguez-Garcia, G.; Hospido, A.; Bagley, D.M.; Moreira, M.T.; Feijoo, G.

    2012-01-01

    The main objective of this paper is to present the Direct Emissions Estimation Model (DEEM), a model for the estimation of CO 2 and N 2 O emissions from a wastewater treatment plant (WWTP). This model is consistent with non-specific but widely used models such as AS/AD and ASM no. 1 and presents the benefits of simplicity and application over a common WWTP simulation platform, BioWin®, making it suitable for Life Cycle Assessment and Carbon Footprint studies. Its application in a Spanish WWTP indicates direct N 2 O emissions to be 8 times larger than those associated with electricity use and thus relevant for LCA. CO 2 emissions can be of similar importance to electricity-associated ones provided that 20% of them are of non-biogenic origin. - Highlights: ► A model has been developed for the estimation of GHG emissions in WWTP. ► Model was consistent with both ASM no. 1 and AS/AD. ► N 2 O emissions are 8 times more relevant than the one associated with electricity. ► CO 2 emissions are as important as electricity if 20% of it is non-biogenic.

  7. A methodology to estimate greenhouse gases emissions in Life Cycle Inventories of wastewater treatment plants

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez-Garcia, G., E-mail: gonzalo.rodriguez.garcia@usc.es [Department of Chemical Engineering, University of Santiago de Compostela, Rua Lope Gomez de Marzoa, S/N, 15782, Santiago de Compostela (Spain); Hospido, A., E-mail: almudena.hospido@usc.es [Department of Chemical Engineering, University of Santiago de Compostela, Rua Lope Gomez de Marzoa, S/N, 15782, Santiago de Compostela (Spain); Bagley, D.M., E-mail: bagley@uwyo.edu [Department of Chemical and Petroleum Engineering, University of Wyoming, 82072 Laramie, WY (United States); Moreira, M.T., E-mail: maite.moreira@usc.es [Department of Chemical Engineering, University of Santiago de Compostela, Rua Lope Gomez de Marzoa, S/N, 15782, Santiago de Compostela (Spain); Feijoo, G., E-mail: gumersindo.feijoo@usc.es [Department of Chemical Engineering, University of Santiago de Compostela, Rua Lope Gomez de Marzoa, S/N, 15782, Santiago de Compostela (Spain)

    2012-11-15

    The main objective of this paper is to present the Direct Emissions Estimation Model (DEEM), a model for the estimation of CO{sub 2} and N{sub 2}O emissions from a wastewater treatment plant (WWTP). This model is consistent with non-specific but widely used models such as AS/AD and ASM no. 1 and presents the benefits of simplicity and application over a common WWTP simulation platform, BioWin Registered-Sign , making it suitable for Life Cycle Assessment and Carbon Footprint studies. Its application in a Spanish WWTP indicates direct N{sub 2}O emissions to be 8 times larger than those associated with electricity use and thus relevant for LCA. CO{sub 2} emissions can be of similar importance to electricity-associated ones provided that 20% of them are of non-biogenic origin. - Highlights: Black-Right-Pointing-Pointer A model has been developed for the estimation of GHG emissions in WWTP. Black-Right-Pointing-Pointer Model was consistent with both ASM no. 1 and AS/AD. Black-Right-Pointing-Pointer N{sub 2}O emissions are 8 times more relevant than the one associated with electricity. Black-Right-Pointing-Pointer CO{sub 2} emissions are as important as electricity if 20% of it is non-biogenic.

  8. Integration of the Brief Behavioral Activation Treatment for Depression (BATD) into a College Orientation Program: Depression and Alcohol Outcomes

    Science.gov (United States)

    Reynolds, Elizabeth K.; MacPherson, Laura; Tull, Matthew T.; Baruch, David E.; Lejuez, C. W.

    2011-01-01

    College freshmen face a variety of academic and social challenges as they adjust to college life that can place them at risk for a number of negative outcomes, including depression and alcohol-related problems. Orientation classes that focus on teaching incoming students how to better cope with college-oriented stress may provide an opportunity to…

  9. Proposal of a sequential treatment methodology for the safe reuse of oil sludge-contaminated soil.

    Science.gov (United States)

    Mater, L; Sperb, R M; Madureira, L A S; Rosin, A P; Correa, A X R; Radetski, C M

    2006-08-25

    In this study sequential steps were used to treat and immobilize oil constituents of an oil sludge-contaminated soil. Initially, the contaminated soil was oxidized by a Fenton type reaction (13 wt% for H(2)O(2); 10mM for Fe(2+)). The oxidative treatment period of 80 h was carried out under three different pH conditions: 20 h at pH 6.5, 20 h at pH 4.5, and 40 h at pH 3.0. The oxidized contaminated sample (3 kg) was stabilized and solidified for 2h with clay (1 kg) and lime (2 kg). Finally, this mixture was solidified by sand (2 kg) and Portland cement (4 kg). In order to evaluate the efficiency of different processes to treat and immobilize oil contaminants of the oil sludge-contaminated soil, leachability and solubility tests were performed and extracts were analyzed according to the current Brazilian waste regulations. Results showed that the Fenton oxidative process was partially efficient in degrading the oil contaminants in the soil, since residual concentrations were found for the PAH and BTEX compounds. Leachability tests showed that clay-lime stabilization/solidification followed by Portland cement stabilization/solidification was efficient in immobilizing the recalcitrant and hazardous constituents of the contaminated soil. These two steps stabilization/solidification processes are necessary to enhance environmental protection (minimal leachability) and to render final product economically profitable. The treated waste is safe enough to be used on environmental applications, like roadbeds blocks.

  10. Treatment of external events in the linked event tree methodology NPP Goesgen - Daeniken example

    International Nuclear Information System (INIS)

    Kozlik, Thomas

    2014-01-01

    The NPP Goesgen-Daeniken uses a combined level 1 / level 2 PSA model for its event analyses. The model uses a linked event tree approach, using the software RISKMAN R . Each initiating event passes through a modularized event tree structure, consisting of external events pre-trees, alignment and support systems trees and front-line and containment response trees. This paper explains the structure of the linked event trees. Switches are used to bypass certain trees for specific initiating events. The screening process applied to possible external events is explained. The final scope of considered natural external events in the Goesgen PSA consists of earthquakes, seasonal events causing cooling water intake plugging or external floods. The structure of the natural external events pre-trees is explained. The treatment of external floods is explained in more detail. Floods at the Goesgen site are caused by extreme river flows into the old branch of the Aare river. A new model has been developed to analyse the probabilistic flood hazard using a bivariate distribution (water level and flood duration). Analysing the statistical data, the time trend had to be considered. The Goesgen PSA models 7 external flood initiating events, considering different water levels and durations at the flooded plant site. The building fragilities were developed in terms of resistance times. The RISKMAN R external flood pre-tree consists of top events for operator actions and failure of the building functions, which leads to the functional failure of equipment located at the lower elevation of the building. (author)

  11. Metodologia para gerenciar projetos de pesquisa e desenvolvimento com foco em produtos: uma proposta Management methodology for product-oriented R&D projects: a proposal

    Directory of Open Access Journals (Sweden)

    Andréia Azevedo Pinheiro

    2006-06-01

    Full Text Available As atividades de pesquisa e desenvolvimento (P&D realizadas nos institutos públicos de pesquisa (IPPs têm como característica uma gestão arraigada nas premissas acadêmicas, que priorizam a geração e difusão do conhecimento. Em contrapartida, a necessidade de competitividade tecnológica no mercado e a pressão pela participação, como instrumentos da política pública do esforço nacional rumo à inovação, têm pressionado os IPPs para a busca por resultados mais concretos. Esse fato acarreta a geração de grandes lacunas nos processos relacionados à gestão, induzindo a uma constante necessidade de aperfeiçoamento gerencial, no sentido de criar e melhorar ferramentas que contribuam para adequá-la à nova realidade. Este artigo propõe uma metodologia de gestão de projetos de P&D, que se baseia no direcionamento dos projetos de pesquisa para a obtenção de produtos, e considera suas características multidisciplinares e interdisciplinares e a incerteza inerentes a esse processo. Essa metodologia foi desenvolvida no Instituto de Tecnologia de Fármacos da Fiocruz e é proposta como um modelo original para instituições semelhantes.The Research and Development (R&D activities carried out at public research institutes have a strongly rooted academic-like management which focuses on knowledge improvement. On the other hand, the need for technological competitiveness and contribution in the national effort towards innovation has lead Brazilian organizations to search for more concrete results: products. This fact accounts for huge gaps in management-related processes and a constant need for managerial improvements in order to generate and perfect tools suitable to a new reality. This article proposes a R&D project management methodology focused on research projects that aim at new technological products taking into consideration the multidisciplinary and interdisciplinary aspects and the uncertainty inherent to this process. It

  12. [Methodological quality evaluation of randomized controlled trials for traditional Chinese medicines for treatment of sub-health].

    Science.gov (United States)

    Zhao, Jun; Liao, Xing; Zhao, Hui; Li, Zhi-Geng; Wang, Nan-Yue; Wang, Li-Min

    2016-11-01

    To evaluate the methodological quality of the randomized controlled trials(RCTs) for traditional Chinese medicines for treatment of sub-health, in order to provide a scientific basis for the improvement of clinical trials and systematic review. Such databases as CNKI, CBM, VIP, Wanfang, EMbase, Medline, Clinical Trials, Web of Science and Cochrane Library were searched for RCTS for traditional Chinese medicines for treatment of sub-health between the time of establishment and February 29, 2016. Cochrane Handbook 5.1 was used to screen literatures and extract data, and CONSORT statement and CONSORT for traditional Chinese medicine statement were adopted as the basis for quality evaluation. Among the 72 RCTs included in this study, 67 (93.05%) trials described the inter-group baseline data comparability, 39(54.17%) trials described the unified diagnostic criteria, 28(38.89%) trials described the unified standards of efficacy, 4 (5.55%) trials mentioned the multi-center study, 19(26.38%) trials disclosed the random distribution method, 6(8.33%) trials used the random distribution concealment, 15(20.83%) trials adopted the method of blindness, 3(4.17%) study reported the sample size estimation in details, 5 (6.94%) trials showed a sample size of more than two hundred, 19(26.38%) trials reported the number of withdrawal, defluxion cases and those lost to follow-up, but only 2 trials adopted the ITT analysis,10(13.89%) trials reported the follow-up results, none of the trial reported the test registration and the test protocol, 48(66.7%) trials reported all of the indicators of expected outcomes, 26(36.11%) trials reported the adverse reactions and adverse events, and 4(5.56%) trials reported patient compliance. The overall quality of these randomized controlled trials for traditional Chinese medicines for treatment of sub-health is low, with methodological defects in different degrees. Therefore, it is still necessary to emphasize the correct application of principles

  13. Potential of the Moringa oleifera saline extract for the treatment of dairy wastewater: application of the response surface methodology.

    Science.gov (United States)

    Formentini-Schmitt, Dalila Maria; Fagundes-Klen, Márcia Regina; Veit, Márcia Teresinha; Palácio, Soraya Moreno; Trigueros, Daniela Estelita Goes; Bergamasco, Rosangela; Mateus, Gustavo Affonso Pisano

    2018-03-02

    In this work, the coagulation/flocculation/sedimentation treatment of dairy wastewater samples was investigated through serial factorial designs utilizing the saline extract obtained from Moringa oleifera (Moringa) as a coagulant. The sedimentation time (ST), pH, Moringa coagulant (MC) dose and concentration of CaCl 2 have been evaluated through the response surface methodology in order to obtain the ideal turbidity removal (TR) conditions. The empirical quadratic model, in conjunction with the desirability function, demonstrated that it is possible to obtain TRs of 98.35% using a coagulant dose, concentration of CaCl 2 and pH of 280 mg L -1 , 0.8 mol L -1 and 9, respectively. The saline extract from Moringa presented its best efficiency at an alkaline pH, which influenced the reduction of the ST to a value of 25 min. It was verified that the increase in the solubility of the proteins in the Moringa stimulated the reduction of the coagulant content in the reaction medium, and it is related to the use of calcium chloride as an extracting agent of these proteins. The MC proved to be an excellent alternative for the dairy wastewater treatment, compared to the traditional coagulants.

  14. Tuning of deep level emission in highly oriented electrodeposited ZnO nanorods by post growth annealing treatments

    International Nuclear Information System (INIS)

    Simimol, A.; Manikandanath, N. T.; Chowdhury, Prasanta; Barshilia, Harish C.; Anappara, Aji A.

    2014-01-01

    Highly dense and c-axis oriented zinc oxide (ZnO) nanorods with hexagonal wurtzite facets were deposited on fluorine doped tin oxide coated glass substrates by a simple and cost-effective electrodeposition method at low bath temperature (80 °C). The as-grown samples were then annealed at various temperatures (T A  = 100–500 °C) in different environments (e.g., zinc, oxygen, air, and vacuum) to understand their photoluminescence (PL) behavior in the ultra-violet (UV) and the visible regions. The PL results revealed that the as-deposited ZnO nanorods consisted of oxygen vacancy (V O ), zinc interstitial (Zn i ), and oxygen interstitial (O i ) defects and these can be reduced significantly by annealing in different environments at optimal annealing temperatures. However, the intensity of deep level emission increased for T A greater than the optimized values for the respective environments due to the introduction of various defect centers. For example, for T A  ≥ 450 °C in the oxygen and air environments, the density of O i defects increased, whereas, the green emission associated with V O is dominant in the vacuum annealed (T A  = 500 °C) ZnO nanorods. The UV peak red shifted after the post-growth annealing treatments in all the environments and the vacuum annealed sample exhibited highest UV peak intensity. The observations from the PL data are supported by the micro-Raman spectroscopy. The present study gives new insight into the origin of different defects that exist in the electrodeposited ZnO nanorods and how these defects can be precisely controlled in order to get the desired emissions for the opto-electronic applications

  15. Development methodology of the novel Endoscopic stone treatment step 1 (EST s1) training/assessment curriculum.

    Science.gov (United States)

    Veneziano, Domenico; Ahmed, Kamran; Van Cleynenbreugel, Ben S E P; Gözen, Ali Serdar; Palou, Joan; Sarica, Kemal; Liatsikos, Evangelos N; Sanguedolce, Francesco; Honeck, Patrick; Alvarez-Maestro, Mario; Papatsoris, Athanasios; Kallidonis, Panagiotis; Greco, Francesco; Breda, Alberto; Somani, Bhaskar

    2017-07-10

    Background Simulation based technical-skill assessment is a core topic of debate, especially in high-risk environments. After the introduction of the E-BLUS exam for basic laparoscopy, no more technical training/assessment urological protocols have been developed in Europe. Objective We describe the methodology used in the development of the novel Endoscopic Stone Treatment step 1 (EST s1) assessment curriculum. Materials and Methods The "full life cycle curriculum development" template was followed for curriculum development. A CTA was run to define the most important steps and details of RIRS, in accordance with EAU Urolithiasis guidelines. Training tasks were created between April 2015 and September 2015. Tasks and metrics were further analyzed by a consensus meeting with the EULIS board in February 2016. A review, aimed to study available simulators and their accordance with task requirements, was subsequently run in London on March 2016. After initial feedback and further tests, content validity of this protocol was achieved during EUREP 2016. Results The EST s1 curriculum development, took 23 months. 72 participants tested the 5 preliminary tasks during EUREP 2015, with sessions of 45 minutes each. Likert-scale questionnaires were filled-out to score the quality of training. The protocol was modified accordingly and 25 participants tested the 4 tasks during the hands-on training sessions of the ESUT 2016 congress. 134 participants finally participated in the validation study in EUREP 2016. During the same event 10 experts confirmed content validity by filling-out a Likert-scale questionnaire. Conclusion We described a reliable and replicable methodology that can be followed to develop training/assessment protocols for surgical procedures. The expert consensus meetings, strict adherence to guidelines and updated literature search towards an Endourology curriculum allowed correct training and assessment protocol development. It is the first step towards

  16. Influence of gender, sexual orientation, and need on treatment utilization for substance use and mental disorders: Findings from the California Quality of Life Survey

    Directory of Open Access Journals (Sweden)

    Mays Vickie M

    2009-08-01

    Full Text Available Abstract Background Prior research has shown a higher prevalence of substance use and mental disorders among sexual minorities, however, the influence of sexual orientation on treatment seeking has not been widely studied. We use a model of help-seeking for vulnerable populations to investigate factors related to treatment for alcohol or drug use disorders and mental health disorders, focusing on the contributions of gender, sexual orientation, and need. Methods Survey data were obtained from a population-based probability sample of California residents that oversampled for sexual minorities. Logistic regression was used to model the enabling, predisposing, and need-related factors associated with past-year mental health or substance abuse treatment utilization among adults aged 18–64 (N = 2,074. Results Compared with individuals without a diagnosed disorder, those with any disorder were more likely to receive treatment. After controlling for both presence of disorder and other factors, lesbians and bisexual women were most likely to receive treatment and heterosexual men were the least likely. Moreover, a considerable proportion of sexual orientation minorities without any diagnosable disorder, particularly lesbians and bisexual women, also reported receiving treatment. Conclusion The study highlights the need to better understand the factors beyond meeting diagnostic criteria that underlie treatment utilization among sexual minorities. Future research should also aim to ascertain the effects of treatment provided to sexual minorities with and without diagnosable disorders, including the possibility that the provision of such treatment may reduce the likelihood of their progression to greater severity of distress, disorders, or impairments in functioning.

  17. Longitudinal relationships between antiretroviral treatment adherence and discrimination due to HIV-serostatus, race, and sexual orientation among African-American men with HIV.

    Science.gov (United States)

    Bogart, Laura M; Wagner, Glenn J; Galvan, Frank H; Klein, David J

    2010-10-01

    African-Americans show worse HIV disease outcomes compared to Whites. Health disparities may be aggravated by discrimination, which is associated with worse health and maladaptive health behaviors. We examined longitudinal effects of discrimination on antiretroviral treatment adherence among 152 HIV-positive Black men who have sex with men. We measured adherence and discrimination due to HIV-serostatus, race/ethnicity, and sexual orientation at baseline and monthly for 6 months. Hierarchical repeated-measures models tested longitudinal effects of each discrimination type on adherence. Over 6 months, participants took 60% of prescribed medications on average; substantial percentages experienced discrimination (HIV-serostatus, 38%; race/ethnicity, 40%; and sexual orientation, 33%). Greater discrimination due to all three characteristics was significantly bivariately associated with lower adherence (all p's discrimination was significant (p < 0.05). Efforts to improve HIV treatment adherence should consider the context of multiple stigmas, especially racism.

  18. Comprehensive MRI simulation methodology using a dedicated MRI scanner in radiation oncology for external beam radiation treatment planning

    International Nuclear Information System (INIS)

    Paulson, Eric S.; Erickson, Beth; Schultz, Chris; Allen Li, X.

    2015-01-01

    Purpose: The use of magnetic resonance imaging (MRI) in radiation oncology is expanding rapidly, and more clinics are integrating MRI into their radiation therapy workflows. However, radiation therapy presents a new set of challenges and places additional constraints on MRI compared to diagnostic radiology that, if not properly addressed, can undermine the advantages MRI offers for radiation treatment planning (RTP). The authors introduce here strategies to manage several challenges of using MRI for virtual simulation in external beam RTP. Methods: A total of 810 clinical MRI simulation exams were performed using a dedicated MRI scanner for external beam RTP of brain, breast, cervix, head and neck, liver, pancreas, prostate, and sarcoma cancers. Patients were imaged in treatment position using MRI-optimal immobilization devices. Radiofrequency (RF) coil configurations and scan protocols were optimized based on RTP constraints. Off-resonance and gradient nonlinearity-induced geometric distortions were minimized or corrected prior to using images for RTP. A multidisciplinary MRI simulation guide, along with window width and level presets, was created to standardize use of MR images during RTP. A quality assurance program was implemented to maintain accuracy and repeatability of MRI simulation exams. Results: The combination of a large bore scanner, high field strength, and circumferentially wrapped, flexible phased array RF receive coils permitted acquisition of thin slice images with high contrast-to-noise ratio (CNR) and image intensity uniformity, while simultaneously accommodating patient setup and immobilization devices. Postprocessing corrections and alternative acquisition methods were required to reduce or correct off-resonance and gradient nonlinearity induced geometric distortions. Conclusions: The methodology described herein contains practical strategies the authors have implemented through lessons learned performing clinical MRI simulation exams. In

  19. Comprehensive MRI simulation methodology using a dedicated MRI scanner in radiation oncology for external beam radiation treatment planning

    Energy Technology Data Exchange (ETDEWEB)

    Paulson, Eric S., E-mail: epaulson@mcw.edu [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 and Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 (United States); Erickson, Beth; Schultz, Chris; Allen Li, X. [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 (United States)

    2015-01-15

    Purpose: The use of magnetic resonance imaging (MRI) in radiation oncology is expanding rapidly, and more clinics are integrating MRI into their radiation therapy workflows. However, radiation therapy presents a new set of challenges and places additional constraints on MRI compared to diagnostic radiology that, if not properly addressed, can undermine the advantages MRI offers for radiation treatment planning (RTP). The authors introduce here strategies to manage several challenges of using MRI for virtual simulation in external beam RTP. Methods: A total of 810 clinical MRI simulation exams were performed using a dedicated MRI scanner for external beam RTP of brain, breast, cervix, head and neck, liver, pancreas, prostate, and sarcoma cancers. Patients were imaged in treatment position using MRI-optimal immobilization devices. Radiofrequency (RF) coil configurations and scan protocols were optimized based on RTP constraints. Off-resonance and gradient nonlinearity-induced geometric distortions were minimized or corrected prior to using images for RTP. A multidisciplinary MRI simulation guide, along with window width and level presets, was created to standardize use of MR images during RTP. A quality assurance program was implemented to maintain accuracy and repeatability of MRI simulation exams. Results: The combination of a large bore scanner, high field strength, and circumferentially wrapped, flexible phased array RF receive coils permitted acquisition of thin slice images with high contrast-to-noise ratio (CNR) and image intensity uniformity, while simultaneously accommodating patient setup and immobilization devices. Postprocessing corrections and alternative acquisition methods were required to reduce or correct off-resonance and gradient nonlinearity induced geometric distortions. Conclusions: The methodology described herein contains practical strategies the authors have implemented through lessons learned performing clinical MRI simulation exams. In

  20. Assessing New Employee Orientation Programs

    Science.gov (United States)

    Acevedo, Jose M.; Yancey, George B.

    2011-01-01

    Purpose: This paper aims to examine the importance of new employee orientation (NEO) programs, the quality of typical NEOs, and how to improve NEOs. Design/methodology/approach: The paper provides a viewpoint of the importance of new employee orientation programs, the quality of typical NEOs, and how to improve NEOs. Findings: Although western…

  1. Emphaty oriented 'creative' teaching and learning methodologies

    NARCIS (Netherlands)

    Guney, A.

    2009-01-01

    Understanding learners’ minds has become one of the major issues of some methodologists in education system. The entire matter is learning. It seems obvious to me it is necessary to explain what learning is in terms of knowledge, in the widest sense. We should also try to find out what kind of

  2. The shorter the better? A follow-up analysis of 10-session psychiatric treatment including the motive-oriented therapeutic relationship for borderline personality disorder.

    Science.gov (United States)

    Kramer, Ueli; Stulz, Niklaus; Berthoud, Laurent; Caspar, Franz; Marquet, Pierre; Kolly, Stéphane; De Roten, Yves; Despland, Jean-Nicolas

    2017-05-01

    There is little research on short-term treatments for borderline personality disorder (BPD). While the core changes may occur only in long-term treatments, short-term treatments may enable the study of early generic processes of engagement in therapy and thus inform about effective treatment components. It was shown that a 10-session version of a psychiatric treatment was effective in reducing borderline symptoms at the end of this treatment [Kramer, U., Kolly, S., Berthoud, L., Keller, S., Preisig, M., Caspar, F., … Despland, J.-N. (2014). Effects of motive-oriented therapeutic relationship in a ten-session general psychiatric treatment for borderline personality disorder: A randomized controlled trial. Psychotherapy and Psychosomatics, 83, 176-186.]. Also, it was demonstrated in a randomized design that adding the motive-oriented therapeutic relationship (MOTR), following an individualized case formulation based on Plan Analysis, further increased general outcome after session 10 and had a positive effect on the early changes in self-esteem and alliance. The present study focuses on the follow-up period after this initial treatment, examining treatment density and outcomes after 6 months and service utilization after 12 months. Outcome was measured using the OQ-45. Results on a sub-sample of N = 40 patients with available OQ-45 data at follow-up (n = 21 for MOTR-treatment, n = 19 for comparison treatment) showed maintenance of gains over the follow-up period, which did not differ between both conditions. It appeared for this sample that MOTR treatments, while using the same number of sessions, lasted more weeks (i.e., lower treatment density, defined as the number of sessions per week), when compared to the treatments without MOTR. Density marginally predicted symptom reduction at follow-up. Patients in MOTR treatments had a greater likelihood of entering structured psychotherapy after the initial sessions than patients in the comparison

  3. A Functional HAZOP Methodology

    DEFF Research Database (Denmark)

    Liin, Netta; Lind, Morten; Jensen, Niels

    2010-01-01

    A HAZOP methodology is presented where a functional plant model assists in a goal oriented decomposition of the plant purpose into the means of achieving the purpose. This approach leads to nodes with simple functions from which the selection of process and deviation variables follow directly...

  4. Development of a methodology to determine optimized therapeutic doses of {sup 131}I for the treatment of hyperthyroidism

    Energy Technology Data Exchange (ETDEWEB)

    Araujo, Francisco de; Santas, Bernardo Maranhao; Dantas, Ana Leticia Almeida; Lucena, Eder Augusto [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)]. E-mail: faraujo@ird.gov.br; Melo, Rossana Corbo de; Rebelo, Ana Maria de Oliveira [Universidade Federal, Rio de Janeiro, RJ (Brazil). Faculdade de Medicina

    2007-07-01

    Several methods can be used to determine the activity of {sup 131}I to be administered for the treatment of hyperthyroidism. However, some of them do not take into consideration the dose absorbed by the thyroid, while others do not consider all the parameters necessary for dose calculation. The relationship between the dose absorbed by the thyroid and the activity administered depends basically on three parameters: mass of the organ, iodine uptake and effective half-life of iodine in the thyroid. Such parameters should be individually determined for each patient in order to optimize the administered activity. The objective of this work is to develop a methodology to evaluate therapeutic doses through the determination of biokinetic parameters and the activity of {sup 131}I deposited in the thyroid of patients submitted to the treatment of hyperthyroidism with {sup 131}I. A neck-thyroid phantom developed at the In Vivo Monitoring Laboratory of IRD, containing a known amount of {sup 131}I, was used to calibrate a scintillation camera and a uptake probe available at the Nuclear Medicine Center of the University Hospital of Rio de Janeiro. The optimization of the counting geometry was carried out by the determination of the characteristic curves of the view angle of the collimator-detector assembly. The calculation of the calibration factor of the scintillation camera allows the determination of activities in the thyroid of patients in pre-established time periods through a 48-hours uptake curve. The view angle of the collimator-detector assembly presented values compatible with the size of the organ for distances of 25 cm (uptake probe) and 45.8 cm (scintillation camera). The calibration factors (in cpm/kBq) and the associated uncertainty related to these distances were 39.3 {+-} 0.8 and 4.3 {+-} 0.2 respectively. The time period between 14 and 30 hours of the retention curve allows the calculation of the activity between those two points. It is concluded that the use

  5. Development of a methodology to determine optimized therapeutic doses of {sup 131}I for the treatment of hyperthyroidism

    Energy Technology Data Exchange (ETDEWEB)

    Araujo, F.; Moura, M.B.; Pereira, A.C., E-mail: faraujo@ird.gov.br [Instituto de Medicna Nuclear (IMEN), Goiania, GO (Brazil); Dantas, B.M.; Dantas, A.L.A.; Lucena, E.A. [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Melo, R.C.; Rebelo, A.M.O. [Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ (Brazil). Faculdade de Medicina

    2008-07-01

    Several methods can be used to determine the activity of {sup 131}I to be administered for the treatment of hyperthyroidism. However, some of them do not take into consideration the dose absorbed by the thyroid, while others do not consider all the parameters necessary for dose calculation. The relationship between the dose absorbed by the thyroid and the activity administered depends basically on three parameters: mass of the organ, iodine uptake and effective half-life of iodine in the thyroid. Such parameters should be individually determined for each patient in order to optimize the administered activity. The objective of this work is to develop a methodology for individualized treatment with {sup 131}I in patients with hyperthyroidism of the Grave's Disease. A neck-thyroid phantom developed at the In Vivo Monitoring Laboratory of IRD, containing a known amount of {sup 131}I, was used to calibrate a scintillation camera and a uptake probe available at the Nuclear Medicine Center of the University Hospital of Rio de Janeiro and Instituto de Medicina Nuclear - IMEN, of Goiania. The optimization of the counting geometry was carried out by the determination of the characteristic curves of the view angle of the collimator-detector assembly. The view angle of the collimator-detector assembly presented values compatible with the size of the organ for distances of 25 cm (uptake probe) and 45.8 cm (scintillation camera). The calibration factors (in cpm/kBq) and the associated uncertainty related to these distances were (39.3 ± 0.78), (58.1 ± 2.38) to uptake probe SCT-13004 e 13002, respectively and 4.3 ± 0.17 to scintillation camera. The time period between 14 and 30 hours of the retention curve allows the calculation of the activity between those two points. It is concluded that the use of diagnose equipment available at the hospital (scintillation camera and uptake probe) has shown to be a suitable procedure in terms of effectiveness, simplicity and cost

  6. Development of a methodology to determine optimized therapeutic doses of 131I for the treatment of hyperthyroidism

    International Nuclear Information System (INIS)

    Araujo, F.; Moura, M.B.; Pereira, A.C.; Dantas, B.M.; Dantas, A.L.A.; Lucena, E.A.; Melo, R.C.; Rebelo, A.M.O.

    2008-01-01

    Several methods can be used to determine the activity of 131 I to be administered for the treatment of hyperthyroidism. However, some of them do not take into consideration the dose absorbed by the thyroid, while others do not consider all the parameters necessary for dose calculation. The relationship between the dose absorbed by the thyroid and the activity administered depends basically on three parameters: mass of the organ, iodine uptake and effective half-life of iodine in the thyroid. Such parameters should be individually determined for each patient in order to optimize the administered activity. The objective of this work is to develop a methodology for individualized treatment with 131 I in patients with hyperthyroidism of the Grave's Disease. A neck-thyroid phantom developed at the In Vivo Monitoring Laboratory of IRD, containing a known amount of 131 I, was used to calibrate a scintillation camera and a uptake probe available at the Nuclear Medicine Center of the University Hospital of Rio de Janeiro and Instituto de Medicina Nuclear - IMEN, of Goiania. The optimization of the counting geometry was carried out by the determination of the characteristic curves of the view angle of the collimator-detector assembly. The view angle of the collimator-detector assembly presented values compatible with the size of the organ for distances of 25 cm (uptake probe) and 45.8 cm (scintillation camera). The calibration factors (in cpm/kBq) and the associated uncertainty related to these distances were (39.3 ± 0.78), (58.1 ± 2.38) to uptake probe SCT-13004 e 13002, respectively and 4.3 ± 0.17 to scintillation camera. The time period between 14 and 30 hours of the retention curve allows the calculation of the activity between those two points. It is concluded that the use of diagnose equipment available at the hospital (scintillation camera and uptake probe) has shown to be a suitable procedure in terms of effectiveness, simplicity and cost. (author)

  7. Methodology of adjustment point in the post treatment of gaseous effluents; Metodologia del punto de ajuste en el post tratamiento de efluentes gaseosos

    Energy Technology Data Exchange (ETDEWEB)

    Vizuet G, J.; Molina, G. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)]. e-mail: jvg@nuclear.inin.mx

    2005-07-01

    The methodology to determine the adjustment points of the monitoring system of gaseous discharges is based on the stipulations of the 10CFR20, which are expressed in terms of limit concentrations for the outstanding radionuclides, and of dose limits for the individuals members of the public. Besides the points of liberation properly said, like they are the chimneys of the reactor buildings and of turbine, the points of adjustment of the monitoring instrumentation that watches in real time the discharge of the Treatment system of output gases, to the HVAC of the waste building; they also undergo to the same methodology, with the approaches previously described. (Author)

  8. Relationship of race-, sexual orientation-, and HIV-related discrimination with adherence to HIV treatment: a pilot study.

    Science.gov (United States)

    Boarts, Jessica M; Bogart, Laura M; Tabak, Melanie A; Armelie, Aaron P; Delahanty, Douglas L

    2008-10-01

    Adherence to highly active antiretroviral therapy (HAART) must be close to perfect in order to maintain suppression of HIV viral load, and to prevent the development of drug resistant strains of HIV. People living with HIV (PLWH) often report low levels of adherence. One variable that has been linked to poor adherence is perceived discrimination; however, research has generally not considered the possible unique effects of different types of discrimination on adherence. The present pilot study aimed to examine the association of three types of discrimination (due to HIV+ status, race, or sexual orientation) with adherence among 57 PLWH. Logistic regression analyses were conducted to demonstrate the relationships between each type of discrimination and self-reported adherence. Racial discrimination significantly predicted lower adherence levels, whereas sexual orientation- and HIV-related discrimination did not. Results underscore the importance of addressing discrimination issues, specifically racial, when designing interventions to improve adherence to HAART.

  9. German Orientalism

    OpenAIRE

    Margaret Olin

    2011-01-01

    Review of: Suzanne L. Marchand, German Orientalism in the Age of Empire: Religion, Race and Scholarship, Cambridge and Washington, D.C.: Cambridge University Press, 2009. This analysis of Suzanne L. Marchand’s German Orientalism in the Age of Empire: Religion, Race and Scholarship reads her contribution in part against the background of Edward Said’s path breaking book Orientalism. Differences lie in her more expansive understanding of the term ‘Oriental’ to include the Far East and her conce...

  10. A comparison of the efficacy of doramectin, closantel and levamisole in the treatment of the 'oriental eye fluke', Philophthalmus gralli, in commercially reared ostriches (Struthio camelus : short communication

    Directory of Open Access Journals (Sweden)

    S. Mukaratirwa

    2008-05-01

    Full Text Available Commercially reared ostriches at Msengi farm situated in the Chinhoyi area of Mashonaland West province in Zimbabwe were found to be infected with the 'oriental eye fluke', Philopthalmus gralli, in 2001. This was the 1st record of the fluke in Zimbabwe. Trials were conducted to identify a suitable drug for the treatment of this fluke. A total of 12 ostriches confirmed to be infected with the fluke through clinical examination of the eyes and identification of the fluke were randomly divided into 3 equal groups, with each group receiving a different treatment protocol. The 3 drugs used were doramectin, levamisole and closantel. Each of the drugs was used in combination with chloramphenicol as an eye ointment. Levamisole was administered topically into the eye whereas doramectin and closantel were administered parenterally as an intramuscular injection. The results indicated a positive response in levamisole-treated birds but there were no noticeable responses to doramectin and closantel treatments.

  11. Magnetic Resonance Imaging Follow-up Study on Two Cases of Lumbar intervertebral Disc Sequestration Patients Treated with Oriental Medicine Treatment

    Directory of Open Access Journals (Sweden)

    Ki-Su Lee

    2011-09-01

    Full Text Available Objectives: The purpose of this study is to report the image changes of two cases of Lumbar intervertebral Disc Sequestration after oriental medical treatment. Methods: We examined 2 patients with Lumbar intervertebral Disc Sequestration who showed changes on MRI images before/after the treatment. And we assessed clinical symptoms by using numeric rating scale(NRS and straight leg raising test(SLRT. Results & Conclusions : In this study, the first MRI examination of Lumbar intervertebral Disc Sequestration patients was performed at the first visit and re-examination of MRI was done after treatment. In each case, the size of the disc sequestration was considerably reduced in MRI image. And both patients represented effective improvment in NRS score and SLRT test angle.

  12. A situational analysis methodology to inform comprehensive HIV prevention and treatment programming, applied in rural South Africa.

    Science.gov (United States)

    Treves-Kagan, Sarah; Naidoo, Evasen; Gilvydis, Jennifer M; Raphela, Elsie; Barnhart, Scott; Lippman, Sheri A

    2017-09-01

    Successful HIV prevention programming requires engaging communities in the planning process and responding to the social environmental factors that shape health and behaviour in a specific local context. We conducted two community-based situational analyses to inform a large, comprehensive HIV prevention programme in two rural districts of North West Province South Africa in 2012. The methodology includes: initial partnership building, goal setting and background research; 1 week of field work; in-field and subsequent data analysis; and community dissemination and programmatic incorporation of results. We describe the methodology and a case study of the approach in rural South Africa; assess if the methodology generated data with sufficient saturation, breadth and utility for programming purposes; and evaluate if this process successfully engaged the community. Between the two sites, 87 men and 105 women consented to in-depth interviews; 17 focus groups were conducted; and 13 health facilities and 7 NGOs were assessed. The methodology succeeded in quickly collecting high-quality data relevant to tailoring a comprehensive HIV programme and created a strong foundation for community engagement and integration with local health services. This methodology can be an accessible tool in guiding community engagement and tailoring future combination HIV prevention and care programmes.

  13. Heterogeneity among violence-exposed women: applying person-oriented research methods.

    Science.gov (United States)

    Nurius, Paula S; Macy, Rebecca J

    2008-03-01

    Variability of experience and outcomes among violence-exposed people pose considerable challenges toward developing effective prevention and treatment protocols. To address these needs, the authors present an approach to research and a class of methodologies referred to as person oriented. Person-oriented tools support assessment of meaningful patterns among people that distinguish one group from another, subgroups for whom different interventions are indicated. The authors review the conceptual base of person-oriented methods, outline their distinction from more familiar variable-oriented methods, present descriptions of selected methods as well as empirical applications of person-oriented methods germane to violence exposure, and conclude with discussion of implications for future research and translation between research and practice. The authors focus on violence against women as a population, drawing on stress and coping theory as a theoretical framework. However, person-oriented methods hold utility for investigating diversity among violence-exposed people's experiences and needs across populations and theoretical foundations.

  14. A methodology for software documentation

    OpenAIRE

    Torres Júnior, Roberto Dias; Ahlert, Hubert

    2000-01-01

    With the growing complexity of window based software and the use of object-oriented, the development of software is getting more complex than ever. Based on that, this article intends to present a methodology for software documentation and to analyze our experience and how this methodology can aid the software maintenance

  15. Data demonstrating the effects of build orientation and heat treatment on fatigue behavior of selective laser melted 17–4 PH stainless steel

    Directory of Open Access Journals (Sweden)

    Aref Yadollahi

    2016-06-01

    Full Text Available Axial fully-reversed strain-controlled (R=−1 fatigue experiments were performed to obtain data demonstrating the effects of building orientation (i.e. vertical versus horizontal and heat treatment on the fatigue behavior of 17–4 PH stainless steel (SS fabricated via Selective Laser Melting (SLM (Yadollahi et al., submitted for publication [1]. This data article provides detailed experimental data including cyclic stress-strain responses, variations of peak stresses during cyclic deformation, and fractography of post-mortem specimens for SLM 17–4 PH SS.

  16. Orienteering injuries

    OpenAIRE

    Folan, Jean M.

    1982-01-01

    At the Irish National Orienteering Championships in 1981 a survey of the injuries occurring over the two days of competition was carried out. Of 285 individual competitors there was a percentage injury rate of 5.26%. The article discusses the injuries and aspects of safety in orienteering.

  17. Note of the methodological flaws in the paper entitled "GSTT1 and GSTM1 polymorphisms predict treatment outcome for breast cancer: a systematic review and meta-analysis".

    Science.gov (United States)

    Qiu, Mali; Wu, Xu; Qu, Xiaobing

    2016-09-01

    With great interest, we read the paper "GSTT1 and GSTM1 polymorphisms predict treatment outcome for breast cancer: a systematic review and meta-analysis" (by Hu XY et al.), which has reached important conclusions that GSTM1 null and GSTT1/GSTM1 double null polymorphisms might be significantly associated with an increased tumor response in breast cancer. The result is encouraging. Nevertheless, several methodological flaws in this meta-analysis are worth noticing.

  18. Future-Oriented LCA

    DEFF Research Database (Denmark)

    Olsen, Stig Irving; Borup, Mads; Andersen, Per Dannemand

    2018-01-01

    LCA is often applied for decision-making that concerns actions reaching near or far into the future. However, traditional life cycle assessment methodology must be adjusted for the prospective and change-oriented purposes, but no standardised way of doing this has emerged yet. In this chapter some...... challenges are described and some learnings are derived. Many of the future-oriented LCAs published so far perform relatively short-term prediction of simple comparisons. But for more long-term time horizons foresight methods can be of help. Scenarios established by qualified experts about future...... technological and economic developments are indispensable in future technology assessments. The uncertainties in future-oriented LCAs are to a large extent qualitative and it is important to emphasise that LCA of future technologies will provide a set of answers and not ‘the’ answer....

  19. The impact of rehabilitation using removable partial dentures and functionally orientated treatment on oral health-related quality of life: a randomised controlled clinical trial.

    Science.gov (United States)

    McKenna, Gerald; Allen, P Finbarr; O'Mahony, Denis; Cronin, Michael; DaMata, Cristiane; Woods, Noel

    2015-01-01

    This study aimed to compare two different tooth replacement strategies for partially dentate older patients; namely functionally orientated treatment according to the principles of the shortened dental arch (SDA) and conventional treatment using removable partial dentures (RPDs) using a randomised controlled clinical trial. The primary outcome measure for this study was impact on oral health-related quality of life (OHRQoL) measured using the short form of the oral health impact profile (OHIP-14). Patients aged 65 years and older were randomly allocated to two different treatment groups: the RPD group and the SDA group. For the RPD group each patient was restored to complete arches with cobalt-chromium RPDs used to replace missing teeth. For the SDA group, patients were restored to a premolar occlusion of 10 occluding pairs of natural and replacement teeth using resin bonded bridgework (RBB). OHRQoL was measured using the OHIP-14 questionnaire administered at baseline, 1 month, 6 months and 12 months after treatment intervention. In total, 89 patients completed the RCT: 44 from the RPD group and 45 from the SDA group. Analysis using a mixed model of covariance (ANCOVA) illustrated that treatment according to the SDA concept resulted in significantly better mean OHIP-14 scores compared with RPD treatment (premovable dentures in terms of impact on OHRQoL. Copyright © 2014 Elsevier Ltd. All rights reserved.

  20. The effect of alkaline treatment and fiber orientation on impact resistant of bio-composites Sansevieria trifasciata fiber/polypropylene as automotive components material

    Science.gov (United States)

    Shieddieque, Apang Djafar; Mardiyati, Suratman, Rochim; Widyanto, Bambang

    2018-04-01

    The increasing amount of car usage is causing an escalated amount of fuel consumption and CO2 emission. It implicates demand for the automotive industry to increase the efficiency of their products, One of the most effective ways to solve the issue is to find green weight light material for the interior automotive component. The Aim of this research was to investigate the effect of alkaline treatment and fiber orientation on the impact resistant of material bio- composite sansevieiria trifasciata fiber/Polypropylene. In this research, bio-composites sansevieria trifasciata fiber/Polypropylene was prepared with random fiber orientation and unidirectional orientation by using a hot press method with pressure 140 Bar and temperature 240°C. Fiber was taken from Sansevieria trifasciata by using mechanical retting. In this study, Sansevieria fiber was given alkaline treatment (mercerization) with NaOH 3% (w/w) solution at temperature 100°C for an hour. The fraction of fiber volume that were used in this experiment are 0%, 5%, 10%, and 15%. The impact test was conducted based on ASTM D 6110 - 04, and the fracture analysis was investigated by scanning electron microscope (SEM). The best result of impact toughness and fracture analysis were achieved by bio composite untreated and unidirectional sansevieria trifasciata fiber/Polypropylene with fiber volume fraction of 15%, which was 48.092kJ/m2 for impact resistant. As compared to the impact toughness standard, which needed for interior automotive component, the impact toughness of sansevieria trifasciata fiber/Polypropylene has fulfilled the standard of the interior material automotive industry. Therefore, this material can be potentially used as materials on the car exterior component.

  1. Behavioral Treatment of Drooling: A Methodological Critique of the Literature With Clinical Guidelines and Suggestions for Future Research

    NARCIS (Netherlands)

    Burg, J.J.W. van der; Didden, H.C.M.; Jongerius, P.H.; Rotteveel, J.J.

    2007-01-01

    Many children with mental retardation and developmental disabilities suffer from the consequences of chronic drooling. Behavioral treatment for drooling should be considered before other, more intrusive treatments such as medication and surgery are implemented. However, empirical studies on

  2. Behavioral treatment of drooling: a methodological critique of the literature with clinical guidelines and suggestions for future research.

    NARCIS (Netherlands)

    Burg, J.J.W. van der; Didden, R.; Jongerius, P.H.; Rotteveel, J.J.

    2007-01-01

    Many children with mental retardation and developmental disabilities suffer from the consequences of chronic drooling. Behavioral treatment for drooling should be considered before other, more intrusive treatments such as medication and surgery are implemented. However, empirical studies on

  3. Comparison of the ESTRO formalism for monitor unit calculation with a Clarkson based algorithm of a treatment planning system and a traditional ''full-scatter'' methodology

    International Nuclear Information System (INIS)

    Pirotta, M.; Aquilina, D.; Bhikha, T.; Georg, D.

    2005-01-01

    The ESTRO formalism for monitor unit (MU) calculations was evaluated and implemented to replace a previous methodology based on dosimetric data measured in a full-scatter phantom. This traditional method relies on data normalised at the depth of dose maximum (z m ), as well as on the utilisation of the BJR 25 table for the conversion of rectangular fields into equivalent square fields. The treatment planning system (TPS) was subsequently updated to reflect the new beam data normalised at a depth z R of 10 cm. Comparisons were then carried out between the ESTRO formalism, the Clarkson-based dose calculation algorithm on the TPS (with beam data normalised at z m and z R ), and the traditional ''full-scatter'' methodology. All methodologies, except for the ''full-scatter'' methodology, separated head-scatter from phantom-scatter effects and none of the methodologies; except for the ESTRO formalism, utilised wedge depth dose information for calculations. The accuracy of MU calculations was verified against measurements in a homogeneous phantom for square and rectangular open and wedged fields, as well as blocked open and wedged fields, at 5, 10, and 20 cm depths, under fixed SSD and isocentric geometries for 6 and 10 MV. Overall, the ESTRO Formalism showed the most accurate performance, with the root mean square (RMS) error with respect to measurements remaining below 1% even for the most complex beam set-ups investigated. The RMS error for the TPS deteriorated with the introduction of a wedge, with a worse RMS error for the beam data normalised at z m (4% at 6 MV and 1.6% at 10 MV) than at z R (1.9% at 6 MV and 1.1% at 10 MV). The further addition of blocking had only a marginal impact on the accuracy of this methodology. The ''full-scatter'' methodology showed a loss in accuracy for calculations involving either wedges or blocking, and performed worst for blocked wedged fields (RMS errors of 7.1% at 6 MV and 5% at 10 MV). The origins of these discrepancies were

  4. Beam-orientation customization using an artificial neural network

    International Nuclear Information System (INIS)

    Rowbottom, C.G.; Webb, S.; Oldham, M.

    1999-01-01

    A methodology for the constrained customization of coplanar beam orientations in radiotherapy treatment planning using an artificial neural network (ANN) has been developed. The geometry of the patients, with cancer of the prostate, was modelled by reducing the external contour, planning target volume (PTV) and organs at risk (OARs) to a set of cuboids. The coordinates and size of the cuboids were given to the ANN as inputs. A previously developed beam-orientation constrained-customization (BOCC) scheme employing a conventional computer algorithm was used to determine the customized beam orientations in a training set containing 45 patient datasets. Twelve patient datasets not involved in the training of the artificial neural network were used to test whether the ANN was able to map the inputs to customized beam orientations. Improvements from the customized beam orientations were compared with standard treatment plans with fixed gantry angles and plans produced from the BOCC scheme. The ANN produced customized beam orientations within 5 deg. of the BOCC scheme in 62.5% of cases. The average difference in the beam orientations produced by the ANN and the BOCC scheme was 7.7 deg. (±1.7, 1 SD). Compared with the standard treatment plans, the BOCC scheme produced plans with an increase in the average tumour control probability (TCP) of 5.7% (±1.4, 1 SD) whilst the ANN generated plans increased the average TCP by 3.9% (±1.3, 1 SD). Both figures refer to the TCP at a fixed rectal normal tissue complication probability (NTCP) of 1%. In conclusion, even using a very simple model for the geometry of the patient, an ANN was able to produce beam orientations that were similar to those produced by a conventional computer algorithm. (author)

  5. Translational and functional oncogenomics. From cancer-oriented genomic screenings to new diagnostic tools and improved cancer treatment.

    Science.gov (United States)

    Medico, Enzo

    2008-01-01

    We present here an experimental pipeline for the systematic identification and functional characterization of genes with high potential diagnostic and therapeutic value in human cancer. Complementary competences and resources have been brought together in the TRANSFOG Consortium to reach the following integrated research objectives: 1) execution of cancer-oriented genomic screenings on tumor tissues and experimental models and merging of the results to generate a prioritized panel of candidate genes involved in cancer progression and metastasis; 2) setup of systems for high-throughput delivery of full-length cDNAs, for gain-of-function analysis of the prioritized candidate genes; 3) collection of vectors and oligonucleotides for systematic, RNA interference-mediated down-regulation of the candidate genes; 4) adaptation of existing cell-based and model organism assays to a systematic analysis of gain and loss of function of the candidate genes, for identification and preliminary validation of novel potential therapeutic targets; 5) proteomic analysis of signal transduction and protein-protein interaction for better dissection of aberrant cancer signaling pathways; 6) validation of the diagnostic potential of the identified cancer genes towards the clinical use of diagnostic molecular signatures; 7) generation of a shared informatics platform for data handling and gene functional annotation. The results of the first three years of activity of the TRANSFOG Consortium are also briefly presented and discussed.

  6. [Guideline-oriented inpatient psychiatric psychotherapeutic/psychosomatic treatment of anxiety disorders : How many personnel are need?].

    Science.gov (United States)

    Bandelow, B; Lueken, U; Wolff, J; Godemann, F; Menzler, C W; Deckert, J; Ströhle, A; Beutel, M; Wiltink, J; Domschke, K; Berger, M

    2016-03-01

    The reimbursement of inpatient psychiatric psychotherapeutic/psychosomatic hospital treatment in Germany is regulated by the German personnel ordinance for psychiatric hospitals (Psych-PV), which has remained unchanged since 1991. The aim of this article was to estimate the personnel requirements for guideline-adherent psychiatric psychotherapeutic hospital treatment. A normative concept for the required psychotherapeutic "dose" for anxiety disorders was determined based on a literature review. The required staffing contingent was compared to the resources provided by the Psych-PV based on category A1. According to the German policy guidelines for outpatient psychotherapy, a quota of 25 sessions of 50 min each (as a rule plus 5 probatory sessions) is reimbursed. This approach is supported by studies on dose-response relationships. As patients undergoing inpatient treatment for anxiety disorders are usually more severely ill than outpatients, a contingent of 30 sessions for the average treatment duration of 5 weeks seems appropriate in order to fully exploit the costly inpatient treatment time (300 min per patient and week). In contrast, only 70 min are reimbursed according to the Psych-PV. The total personnel requirement for the normative concept is 624 min per patient and week. The Psych-PV only covers 488 min (78 %). Currently, the time contingents for evidence-based psychiatric psychotherapeutic/psychosomatic hospital care are nowhere near sufficient. In the development of future reimbursement systems this needs to be corrected.

  7. Helping concerned family members of individuals with substance use and concurrent disorders: An evaluation of a family member-oriented treatment program.

    Science.gov (United States)

    Denomme, William James; Benhanoh, Orry

    2017-08-01

    There is a growing body of research demonstrating that families of individuals with substance use and concurrent disorders (SUCD) experience a wide range of biopsychosocial problems that significantly impedes their quality of life and health. However, there has been a relative lack of treatment programs primarily focused on improving the well-being and quality of life of these family members. The current study assessed the efficacy of such a program at reducing stress, increasing perceived social support from family and friends, and increasing general, dyadic, and self-rated family functioning within these concerned family members. A sample of 125 family members of individuals with SUCDs was recruited, of which 97 participated in the treatment program and 28 were used as the comparison group. Results indicated that the treatment program significantly reduced stress, increased perceived social support from family and friends, and increased general, dyadic and self-rated family functioning. A perceived personal benefits questionnaire demonstrated that participants had a better understanding of SUCDs, better coping capabilities in regard to emotional difficulties, adopted stronger coping methods, participated in more leisure activities, and improved their relationship with the individual with a SUCD. The results of the current study further demonstrate the need to implement more of these family-member oriented psycho-educational treatment programs. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Behavioral Treatment of Drooling: A Methodological Critique of the Literature with Clinical Guidelines and Suggestions for Future Research

    Science.gov (United States)

    Van der Burg, Jan J. W.; Didden, Robert; Jongerius, Peter H.; Rotteveel, Jan J.

    2007-01-01

    Many children with mental retardation and developmental disabilities suffer from the consequences of chronic drooling. Behavioral treatment for drooling should be considered before other, more intrusive treatments such as medication and surgery are implemented. However, empirical studies on behavioral procedures are scarce. This article reviews 19…

  9. Constrained customization of non-coplanar beam orientations in radiotherapy of brain tumours

    International Nuclear Information System (INIS)

    Rowbottom, C.G.; Oldham, M.; Webb, S.

    1999-01-01

    A methodology for the constrained customization of non-coplanar beam orientations in radiotherapy treatment planning has been developed and tested on a cohort of five patients with tumours of the brain. The methodology employed a combination of single and multibeam cost functions to produce customized beam orientations. The single-beam cost function was used to reduce the search space for the multibeam cost function, which was minimized using a fast simulated annealing algorithm. The scheme aims to produce well-spaced, customized beam orientations for each patient that produce low dose to organs at risk (OARs). The customized plans were compared with standard plans containing the number and orientation of beams chosen by a human planner. The beam orientation constraint-customized plans employed the same number of treatment beams as the standard plan but with beam orientations chosen by the constrained-customization scheme. Improvements from beam orientation constraint-customization were studied in isolation by customizing the beam weights of both plans using a dose-based downhill simplex algorithm. The results show that beam orientation constraint-customization reduced the maximum dose to the orbits by an average of 18.8 (±3.8, 1SD)% and to the optic nerves by 11.4 (±4.8, 1SD)% with no degradation of the planning target volume (PTV) dose distribution. The mean doses, averaged over the patient cohort, were reduced by 4.2 (±1.1, 1SD)% and 12.4 (±3.1 1SD)% for the orbits and optic nerves respectively. In conclusion, the beam orientation constraint-customization can reduce the dose to OARs, for few-beam treatment plans, when compared with standard treatment plans developed by a human planner. (author)

  10. A Multi-site, Two-Phase, Prescription Opioid Addiction Treatment Study (POATS): Rationale, Design, and Methodology

    Science.gov (United States)

    Weiss, Roger D.; Potter, Jennifer Sharpe; Provost, Scott E.; Huang, Zhen; Jacobs, Petra; Hasson, Albert; Lindblad, Robert; Connery, Hilary Smith; Prather, Kristi; Ling, Walter

    2010-01-01

    The National Institute on Drug Abuse Clinical Trials Network launched the Prescription Opioid Addiction Treatment Study (POATS) in response to rising rates of prescription opioid dependence and gaps in understanding the optimal course of treatment for this population. POATS employed a multi-site, two-phase adaptive, sequential treatment design to approximate clinical practice. The study took place at 10 community treatment programs around the United States. Participants included men and women age ≥18 who met Diagnostic and Statistical Manual, 4th Edition criteria for dependence upon prescription opioids, with physiologic features; those with a prominent history of heroin use (according to pre-specified criteria) were excluded. All participants received buprenorphine/naloxone (bup/nx). Phase 1 consisted of 4 weeks of bup/nx treatment, including a 14-day dose taper, with 8 weeks of follow-up. Phase 1 participants were monitored for treatment response during these 12 weeks. Those who relapsed to opioid use, as defined by pre-specified criteria, were invited to enter Phase 2; Phase 2 consisted of 12 weeks of bup/nx stabilization treatment, followed by a 4-week taper and 8 weeks of post-treatment follow-up. Participants were randomized at the beginning of Phase 1 to receive bup/nx, paired with either Standard Medical Management (SMM) or Enhanced Medical Management (EMM; defined as SMM plus individual drug counseling). Eligible participants entering Phase 2 were re-randomized to either EMM or SMM. POATS was developed to determine what benefit, if any, EMM offers over SMM in short-term and longer-term treatment paradigm. This paper describes the rationale and design of the study. PMID:20116457

  11. Sexual orientation differences in treatment expectation, alliance, and outcome among patients at risk for suicide in a public psychiatric hospital

    OpenAIRE

    Pl?derl, Martin; Kunrath, Sabine; Cramer, Robert J.; Wang, Jen; Hauer, Larissa; Fartacek, Clemens

    2017-01-01

    Background Sexual minority (SM) individuals (gay, lesbian, bisexual, or otherwise nonheterosexual) are at increased risk for mental disorders and suicide and adequate mental healthcare may be life-saving. However, SM patients experience barriers in mental healthcare that have been attributed to the lack of SM-specific competencies and heterosexist attitudes and behaviors on the part of mental health professionals. Such barriers could have a negative impact on common treatment factors such as ...

  12. Systematic review of randomized controlled trials of candidate treatments for cognitive impairment in depression and methodological challenges in the field

    DEFF Research Database (Denmark)

    Miskowiak, K. W.; Ott, C. V.; Petersen, Jeff Zarp

    2016-01-01

    to reduced depression severity), and/or insufficient details on how the allocation sequence was generated or how blinding was maintained. Several promising treatments were identified, including vortioxetine, erythropoietin, transcranial direct current stimulation and cognitive remediation. However, several...

  13. Outcomes of comprehensive fixed appliance orthodontic treatment: A systematic review with meta-analysis and methodological overview.

    Science.gov (United States)

    Papageorgiou, Spyridon N; Höchli, Damian; Eliades, Theodore

    2017-11-01

    The aim of this systematic review was to assess the occlusal outcome and duration of fixed orthodontic therapy from clinical trials in humans with the Objective Grading System (OGS) proposed by the American Board of Orthodontics. Nine databases were searched up to October 2016 for prospective/retrospective clinical trials assessing the outcomes of orthodontic therapy with fixed appliances. After duplicate study selection, data extraction, and risk of bias assessment according to the Cochrane guidelines, random-effects meta-analyses of the mean OGS score and treatment duration were performed and 95% confidence intervals (CIs) were calculated. A total of 34 relevant clinical trials including 6,207 patients (40% male, 60% female; average age, 18.4 years) were identified. The average OGS score after treatment was 27.9 points (95% CI, 25.3-30.6 points), while the average treatment duration was 24.9 months (95% CI, 24.6-25.1 months). There was no significant association between occlusal outcome and treatment duration, while considerable heterogeneity was identified. In addition, orthodontic treatment involving extraction of four premolars appeared to have an important effect on both outcomes and duration of treatment. Finally, only 10 (39%) of the identified studies matched compared groups by initial malocclusion severity, although meta-epidemiological evidence suggested that matching may have significantly influenced their results. The findings from this systematic review suggest that the occlusal outcomes of fixed appliance treatment vary considerably, with no significant association between treatment outcomes and duration. Prospective matched clinical studies that use the OGS tool are needed to compare the effectiveness of orthodontic appliances.

  14. Application of Gamma Irradiation and Its Convergent Treatments on Several Varieties of Oriental Hybrid Lily to Control Leaf Blight

    Directory of Open Access Journals (Sweden)

    Ji-Hoon Kim

    2014-06-01

    Full Text Available In order to seek more eco-friend, economic and safer quarantine method than current methyl bromide fumigation, the convergent treatment with 200 Gy of gamma irradiation and several chemicals such as nano-siver particles (NSS, sodium dichloroisocyanurate (NaDCC was tried on the cuttings of lily in the packing of catonnage box for export. With 6 independent experiments of gamma irradiation on the three lily cultivars, cvs. Siberia, Le reve and Sorbonne, incidence and severity of lily leaf blight was investigated on leaves and petals at 8-d after infection. 200 Gy of gamma irradiation decreased at 13-25% of severity on the leaf of Sorbonne, but it increased at 2-5% of severity on the leaf of Siberia and Le reve. Chemical substitutes such as NSS and NaDCC were not effective to control of lily blight on cuttings. By 200 Gy of gamma irradiation treatment, chlorophyll contents were statistically significantly decreased at 12-d after irradiation and the longevities vaselife of fully open flower of Siberia and Sorbonne were increased at 0.4 to 1.2 days. In addition, the relative fresh weights of the gamma irradiated cuttings were severely dried compared to the non-irradiated control. On the other hands, the symptoms of phyto-toxicity of high dose gamma irradiation at 1 or 2 kGy on cv. Siberia were to be blight at the tip of bloom, bent necks of flower, and delayed the process of flowering.

  15. Orienteering club

    CERN Multimedia

    Club d'orientation

    2015-01-01

    Course d'orientation La reprise des courses d’orientation était attendue dans la région puisque près de 150 coureurs ont participé à la première épreuve automnale organisée par le club d’orientation du CERN sur le site de La Faucille. Les circuits ont été remportés par Yann Locatelli du club d’Orientation Coeur de Savoie avec 56 secondes d’avance sur Damien Berguerre du club SOS Sallanches pour le parcours technique long, Marie Vuitton du club CO CERN (membre également de l’Equipe de France Jeune) pour le parcours technique moyen avec presque 4 minutes d’avance sur Jeremy Wichoud du club Lausanne-Jorat, Victor Dannecker pour le circuit technique court devant Alina Niggli, Elliot Dannecker pour le facile moyen et Alice Merat sur le facile court, tous membres du club O’Jura. Les résultats comp...

  16. Oriental cholangiohepatitis

    International Nuclear Information System (INIS)

    Scheible, F.W.; Davis, G.B.; California Univ., San Diego, La Jolla

    1981-01-01

    The recent influx of immigrants from Southeast Asia into the United States has increased the likelihood of encountering unusual diseases heretofore rarely seen in this country. Among these disorders is Oriental cholangiohepatitis, a potentially life-threatening process whose early diagnosis is facilitated by roentgenographic findings. Ultrasonography can also provide useful information, although potential pitfalls in diagnosis should be recognized. (orig.)

  17. Oriental cholangiohepatitis

    Energy Technology Data Exchange (ETDEWEB)

    Scheible, F.W.; Davis, G.B.

    1981-07-15

    The recent influx of immigrants from Southeast Asia into the United States has increased the likelihood of encountering unusual diseases heretofore rarely seen in this country. Among these disorders is Oriental cholangiohepatitis, a potentially life-threatening process whose early diagnosis is facilitated by roentgenographic findings. Ultrasonography can also provide useful information, although potential pitfalls in diagnosis should be recognized.

  18. Radioactive Waste Evaporation: Current Methodologies Employed for the Development, Design, and Operation of Waste Evaporators at the Savannah River Site and Hanford Waste Treatment Plant

    International Nuclear Information System (INIS)

    Calloway, T.B.

    2003-01-01

    Evaporation of High level and Low Activity (HLW and LAW) radioactive wastes for the purposes of radionuclide separation and volume reduction has been conducted at the Savannah River and Hanford Sites for more than forty years. Additionally, the Savannah River Site (SRS) has used evaporators in preparing HLW for immobilization into a borosilicate glass matrix. This paper will discuss the methodologies, results, and achievements of the SRTC evaporator development program that was conducted in support of the SRS and Hanford WTP evaporator processes. The cross pollination and application of waste treatment technologies and methods between the Savannah River and Hanford Sites will be highlighted. The cross pollination of technologies and methods is expected to benefit the Department of Energy's Mission Acceleration efforts by reducing the overall cost and time for the development of the baseline waste treatment processes

  19. Design and methodology of a randomized clinical trial of home-based telemental health treatment for U.S. military personnel and veterans with depression.

    Science.gov (United States)

    Luxton, David D; Pruitt, Larry D; O'Brien, Karen; Stanfill, Katherine; Jenkins-Guarnieri, Michael A; Johnson, Kristine; Wagner, Amy; Thomas, Elissa; Gahm, Gregory A

    2014-05-01

    Home-based telemental health (TMH) treatments have the potential to address current and future health needs of military service members, veterans, and their families, especially for those who live in rural or underserved areas. The use of home-based TMH treatments to address the behavioral health care needs of U.S. military healthcare beneficiaries is not presently considered standard of care in the Military Health System. The feasibility, safety, and clinical efficacy of home-based TMH treatments must be established before broad dissemination of home-based treatment programs can be implemented. This paper describes the design, methodology, and protocol of a clinical trial that compares in-office to home-based Behavioral Activation for Depression (BATD) treatment delivered via web-based video technology for service members and veterans with depression. This grant funded three-year randomized clinical trial is being conducted at the National Center for Telehealth and Technology at Joint-base Lewis-McChord and at the Portland VA Medical Center. Best practice recommendations regarding the implementation of in-home telehealth in the military setting as well as the cultural and contextual factors of providing in-home care to active duty and veteran military populations are also discussed. Published by Elsevier Inc.

  20. Pesticides residues in water treatment plant sludge: validation of analytical methodology using liquid chromatography coupled to Tandem mass spectrometry (LC-MS/MS)

    International Nuclear Information System (INIS)

    Moracci, Luiz Fernando Soares

    2008-01-01

    The evolving scenario of Brazilian agriculture brings benefits to the population and demands technological advances to this field. Constantly, new pesticides are introduced encouraging scientific studies with the aim of determine and evaluate impacts on the population and on environment. In this work, the evaluated sample was the sludge resulted from water treatment plant located in the Vale do Ribeira, Sao Paulo, Brazil. The technique used was the reversed phase liquid chromatography coupled to electrospray ionization tandem mass spectrometry. Compounds were previously liquid extracted from the matrix. The development of the methodology demanded data processing in order to be transformed into reliable information. The processes involved concepts of validation of chemical analysis. The evaluated parameters were selectivity, linearity, range, sensitivity, accuracy, precision, limit of detection, limit of quantification and robustness. The obtained qualitative and quantitative results were statistically treated and presented. The developed and validated methodology is simple. As results, even exploring the sensitivity of the analytical technique, the work compounds were not detected in the sludge of the WTP. One can explain that these compounds can be present in a very low concentration, can be degraded under the conditions of the water treatment process or are not completely retained by the WTP. (author)

  1. Some implications of the Hartree product treatment of the quantum nuclei in the ab initio nuclear–electronic orbital methodology

    Energy Technology Data Exchange (ETDEWEB)

    Gharabaghi, Masumeh [Faculty of Chemical and Petroleum Sciences, Shahid Beheshti University, G. C., Evin, Tehran, 19839, P.O. Box 19395-4716 (Iran, Islamic Republic of); Shahbazian, Shant, E-mail: chemist_shant@yahoo.com [Department of Physics, Shahid Beheshti University, G. C., Evin, Tehran, 19839, P.O. Box 19395-4716 (Iran, Islamic Republic of)

    2016-12-09

    In this letter the conceptual and computational implications of the Hartree product type nuclear wavefunction introduced recently within the context of the ab initio non-Born–Oppenheimer Nuclear–electronic orbital (NEO) methodology are considered. It is demonstrated that this wavefunction may imply a pseudo-adiabatic separation of the nuclei and electrons and each nucleus is conceived as a quantum oscillator while a non-Coulombic effective Hamiltonian is deduced for electrons. Using the variational principle this Hamiltonian is employed to derive a modified set of single-component Hartree–Fock equations which are equivalent to the multi-component version derived previously within the context of the NEO and, easy to be implemented computationally. - Highlights: • The Hartree product wavefunction is used for the quantum nuclei of a molecule. • With this wavefunction quantum nuclei may be conceived as quantum oscillators. • Using variational integral, non-Coulomb effective electronic Hamiltonian was derived. • A set of modified Hartree–Fock equations were derived from this Hamiltonian. • The derived equations are equivalent to the multi-component Hartree–Fock equations.

  2. Clinical evidence of traditional vs fast track recovery methodologies after total arthroplasty for osteoarthritic knee treatment. A retrospective observational study

    Science.gov (United States)

    Castorina, Sergio; Guglielmino, Claudia; Castrogiovanni, Paola; Szychlinska, Marta Anna; Ioppolo, Francesco; Massimino, Paolo; Leonardi, Pietro; Maci, Christian; Iannuzzi, Maurizio; Di Giunta, Angelo; Musumeci, Giuseppe

    2017-01-01

    Summary Background During the last years, programs to enhance postoperative recovery and decrease morbidity after total knee arthroplasty, have been developed across a variety of surgical procedures and referred to as “Fast-Track Surgery”. In this study we aimed to find some answers in the management of osteoarthritic patients subjected to total knee arthroplasty, by using the Fast-Track methodology. To this purpose we evaluated parameters such as early mobilization of patients, better pain management, bleeding, possible complications, reduced hospitalization time, an overall improved recovery and patient satisfaction. Methods 132 patients were selected, of which, 95 treated with “Fast Track” method and 37 treated with traditional method (control group). All the patients were hospitalized and underwent the same rehabilitation program for the first three days after surgery. Results In both groups, the parameters of pain and deformity demonstrated the most rapid improvement, while those of function and movement were normalized as gradual and progressive improvement over the next 2 months. The different functional test used (Barthel, MRC, VAS) showed that the mean values were significantly greater in Fast Track group when compared to the control. Conclusion The results of the study confirm that the application of the Fast Track protocol in orthopaedics after total knee replacement results in rapid post-surgery recovery. Level of evidence IV. Case series, low-quality cohort or case-control studies. PMID:29387645

  3. Diversity-oriented peptide stapling

    DEFF Research Database (Denmark)

    Tran, Thu Phuong; Larsen, Christian Ørnbøl; Røndbjerg, Tobias

    2017-01-01

    as a powerful method for peptide stapling. However, to date CuAAC stapling has not provided a simple method for obtaining peptides that are easily diversified further. In the present study, we report a new diversity-oriented peptide stapling (DOPS) methodology based on CuAAC chemistry. Stapling of peptides...

  4. Problem-oriented approach to Ancient philosophy

    Directory of Open Access Journals (Sweden)

    Berstov, Igor

    2007-06-01

    Full Text Available Igor Berestov and Marina Wolf of the Institute of philosophy and law, Novosibirsk, discuss various methodological difficulties typical of studies in the history of Ancient Greek philosophy and try to develop their own problem-oriented approach.

  5. Studying the effects of classic hallucinogens in the treatment of alcoholism: rationale, methodology, and current research with psilocybin.

    Science.gov (United States)

    Bogenschutz, Michael P

    2013-03-01

    Recent developments in the study of classic hallucinogens, combined with a re-appraisal of the older literature, have led to a renewal of interest in possible therapeutic applications for these drugs, notably their application in the treatment of addictions. This article will first provide a brief review of the research literature providing direct and indirect support for the possible therapeutic effects of classic hallucinogens such as psilocybin and lysergic acid diethylamide (LSD) in the treatment of addictions. Having provided a rationale for clinical investigation in this area, we discuss design issues in clinical trials using classic hallucinogens, some of which are unique to this class of drug. We then discuss the current status of this field of research and design considerations in future randomized trials.

  6. Waste water treatment by ionizing radiations. Removal of biological and chemical risks by water and sludge treatment with electron beams. Orientation 10 July 2002

    International Nuclear Information System (INIS)

    2002-01-01

    This report aims at analysing the reliability of the application of electron ionizing radiation in the treatment of waste waters and effluents, and at identifying possible fields of application and associated technological and economic implications. After some recalls on physics, electrochemistry, radiolysis, and water pollution, the report proposes an overview of the technique of irradiation of waters, with its scientific background (water radiolysis, chemical and biological effects), its process (recovery cycle and possible interventions, processed pollutants), the case of irradiation by electrons (power, rate, flexibility), an overview of benefits and drawbacks, and a brief history of this practice and an overview of current researches. After a recall of regulatory and political requirements, the report discusses possible fields of application: waste water treatment plants, domestic, agricultural and urban sewage wasters, hospital and medical wastes, liquid food industry products, industrial waters. The choice of accelerator parameters and components is then discussed

  7. Effect of Low-Pressure Nitrogen DC Plasma Treatment on the Surface Properties of Biaxially Oriented Polypropylene, Poly (Methyl Methacrylate) and Polyvinyl Chloride Films

    International Nuclear Information System (INIS)

    Mortazavi, S. Hamideh; Ghoranneviss, Mahmood; Pilehvar, Soheil; Esmaeili, Sina; Zargham, Shamim; Hashemi, S. Ebrahim; Jodat, Hamzeh

    2013-01-01

    In this study, commercial biaxially oriented polypropylene (BOPP), polyvinyl chloride (PVC) and poly (methyl methacrylate) (PMMA) films were treated with nitrogen plasma over different exposure times in a Pyrex tube surrounded by a DC variable magnetic field. The chemical changes that appeared on the surface of the samples were investigated using Fourier transform infrared (FT-IR) spectroscopy and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy after treatment for 2 min, 4 min and 6 min in a nitrogen plasma chamber. Effects of the plasma treatment on the surface topographies and contact angles of the untreated and plasma treated films were also analyzed by atomic force microscopy (AFM) and a contact angle measuring system. The results show that the plasma treated films become more hydrophilic with an enhanced wettability due to the formation of some new polar groups on the surface of the treated films. Moreover, at higher exposure times, the total surface energy in all treated films increased while a reduction in contact angle occurred. The behavior of surface roughness in each sample was completely different at higher exposure times. (plasma technology)

  8. Use of reflexology foot massage to reduce anxiety in hospitalized cancer patients in chemotherapy treatment: methodology and outcomes.

    Science.gov (United States)

    Quattrin, R; Zanini, A; Buchini, S; Turello, D; Annunziata, M A; Vidotti, C; Colombatti, A; Brusaferro, S

    2006-03-01

    To examine the effectiveness of reflexology foot massage in hospitalized cancer patients undergoing second or third chemotherapy cycles. Since the late-1970s, studies have been conducted to assess the efficacy of behavioural and relaxation approaches in controlling nausea/vomiting, anxiety and other side-effects associated with chemotherapy. The study consisted of 30 patients being admitted to the oncology unit at a Scientific Research Hospital in Italy. Only 15 of the 30 participants received therapeutic massage. The subjects' self-reports of anxiety (measured by the Spielberger State-Trait Anxiety Inventory) were recorded before, after and 24 hours after the intervention. There was an average decrease of 7.9 points on the state-anxiety scale in the treatment group and of 0.8 points in the control group (P Reflexology foot massage can be considered a support treatment used in combination with traditional medical treatments and executed by an expert, qualified person to help cancer patients receiving chemotherapy feel better and also cope better with their disease.

  9. Orientation Club

    CERN Multimedia

    Club d'orientation

    2014-01-01

    COURSE ORIENTATION Résultats de samedi 10 mai    C’est sur une carte entièrement réactualisée dans les bois de Versoix, que plus de 100 coureurs sont venus participer à la course d’orientation, type longue distance, préparée par des membres du club du CERN. Le terrain plutôt plat nécessitait une orientation à grande vitesse, ce qui a donné les podiums suivants :  Technique long avec 17 postes : 1er Jurg Niggli, O’Jura en 52:48, 2e Beat Muller, COLJ Lausanne-Jorat en 58:02, 3e Christophe Vuitton, CO CERN en 58:19 Technique moyen avec 13 postes : 1er Jean-Bernard Zosso, CO CERN, en 46:05 ; 2e Yves Rousselot, Balise 25 Besançon, en 55:11 ; 3e Laurent Merat, O'Jura, en 55:13 Technique court avec 13 postes : 1er Julien Vuitton, CO CERN en 40:59, 2e Marc Baumgartner, CO CERN en 43:18, 3e Yaelle Mathieu en 51:42 Su...

  10. Orienteering Club

    CERN Multimedia

    Club d'orientation

    2013-01-01

    Courses d’orientation ce printemps Le Club d’orientation du CERN vous invite à venir découvrir la course d’orientation et vous propose, en partenariat avec d’autres clubs de la région, une dizaine de courses populaires. Celles-ci ont lieu les samedis après-midi, elles sont ouvertes à tous, quel que soit le niveau, du débutant au sportif confirmé, en famille ou en individuel, en promenade ou en course. Si vous êtes débutant vous pouvez profiter d’une petite initiation offerte par l’organisateur avant de vous lancer sur un parcours. Divers types de parcours sont à votre choix lors de chaque épreuve : facile court (2-3 km), facile moyen (3-5 km), technique court (3-4 km), technique moyen (4-5 km) et technique long (5-7 km). Les dates à retenir sont les suivantes : Samedi 23 mars: Pully (Vd) Samedi 13 avril: Pougny...

  11. Oriental upper blepharoplasty.

    Science.gov (United States)

    Weng, Chau-Jin

    2009-02-01

    Aesthetic surgery of the upper eyelids is a very common procedure performed in cosmetic practices around the world. The word blepharoplasty, however, has a different meaning in Asia than it does elsewhere. Orientals have different periorbital anatomic characteristics, their motivations for seeking eyelid treatment are different, and operative techniques have been adapted consequently. There are also many eyelid shapes among Orientals, mostly with regard to the presence and location of the supratarsal fold and/or presence of an epicanthal fold. The surgeon must therefore master a range of surgical procedures to treat these variations adequately. It is critical to know the indications for each blepharoplasty technique as well as their complications to select the right surgery and avoid unfavorable results. Epicanthoplasty performed on the right patient can greatly improve aesthetic results while retaining ethnic characteristics. This article will discuss Oriental eyelid characteristics, preoperative patient assessment, commonly used corrective techniques for the "double-eyelid" creation, and complications and how to avoid them.

  12. Elderly Patients with Dementia-Related Symptoms of Severe Agitation and Aggression: Consensus Statement on Treatment Options, Clinical Trials Methodology, and Policy

    Science.gov (United States)

    Salzman, C; Jeste, D; Meyer, RE; Cohen-Mansfield, J; Cummings, J; Grossberg, G; Jarvik, L; Kraemer, H; Lebowitz, B; Maslow, K; Pollock, B; Raskind, M; Schultz, S; Wang, P; Zito, JM; Zubenko, GS

    2009-01-01

    Atypical antipsychotic drugs have been used off-label in clinical practice for treatment of serious dementia-associated agitation and aggression. Following reports of cerebrovascular adverse events associated with the use of atypical antipsychotic in elderly patients with dementia, the FDA issued black box warnings for several atypical antipsychotics, titled “Cerebrovascular Adverse Events, including Stroke, in Elderly Patients with Dementia.” Subsequently, the FDA initiated a meta-analysis of safety data from 17 registration trials across six antipsychotic drugs (five atypical antipsychotics and haloperidol). In 2005, the Agency issued a black box warning regarding increased risk of mortality associated with the use of atypical antipsychotic drugs in this patient population. Geriatric mental health experts participating in a 2006 consensus conference reviewed evidence on the safety and efficacy of antipsychotics, as well as nonpharmacologic approaches, in treating dementia-related symptoms of agitation and aggression. They concluded that, while problems in clinical trials design may have been one of the contributors to the failure to find a signal of drug efficacy, the findings related to drug safety should be taken seriously by clinicians in assessing the potential risks and benefits of treatment in a frail population, and in advising families about treatment. Information provided to patients and family members should be documented in the patient’s chart. Drugs should be used only when non-pharmacologic approaches have failed to adequately control behavioral disruption. Participants also agreed that that there is a need for an FDA-approved medication for the treatment of severe, persistent or recurrent dementia-related symptoms of agitation and aggression (even in the absence of psychosis), that are unresponsive to nonpharmacologic intervention. The authors have outlined methodological enhancements to better evaluate treatment approaches in future

  13. SEISMIC DESIGN REQUIREMENTS SELECTION METHODOLOGY FOR THE SLUDGE TREATMENT and M-91 SOLID WASTE PROCESSING FACILITIES PROJECTS

    International Nuclear Information System (INIS)

    RYAN GW

    2008-01-01

    In complying with direction from the U.S. Department of Energy (DOE), Richland Operations Office (RL) (07-KBC-0055, 'Direction Associated with Implementation of DOE-STD-1189 for the Sludge Treatment Project,' and 08-SED-0063, 'RL Action on the Safety Design Strategy (SDS) for Obtaining Additional Solid Waste Processing Capabilities (M-91 Project) and Use of Draft DOE-STD-I 189-YR'), it has been determined that the seismic design requirements currently in the Project Hanford Management Contract (PHMC) will be modified by DOE-STD-1189, Integration of Safety into the Design Process (March 2007 draft), for these two key PHMC projects. Seismic design requirements for other PHMC facilities and projects will remain unchanged. Considering the current early Critical Decision (CD) phases of both the Sludge Treatment Project (STP) and the Solid Waste Processing Facilities (M-91) Project and a strong intent to avoid potentially costly re-work of both engineering and nuclear safety analyses, this document describes how Fluor Hanford, Inc. (FH) will maintain compliance with the PHMC by considering both the current seismic standards referenced by DOE 0 420.1 B, Facility Safety, and draft DOE-STD-1189 (i.e., ASCE/SEI 43-05, Seismic Design Criteria for Structures, Systems, and Components in Nuclear Facilities, and ANSI ANS 2.26-2004, Categorization of Nuclear Facility Structures, Systems and Components for Seismic Design, as modified by draft DOE-STD-1189) to choose the criteria that will result in the most conservative seismic design categorization and engineering design. Following the process described in this document will result in a conservative seismic design categorization and design products. This approach is expected to resolve discrepancies between the existing and new requirements and reduce the risk that project designs and analyses will require revision when the draft DOE-STD-1189 is finalized

  14. Measurement of Cue-Induced Craving in Human Methamphetamine- Dependent Subjects New Methodological Hopes for Reliable Assessment of Treatment Efficacy

    Directory of Open Access Journals (Sweden)

    Zahra Alam Mehrjerdi

    2011-09-01

    Full Text Available Methamphetamine (MA is a highly addictive psychostimulant drug with crucial impacts on individuals on various levels. Exposure to methamphetamine-associated cues in laboratory can elicit measureable craving and autonomic reactivity in most individuals with methamphetamine dependence and the cue reactivity can model how craving would result in continued drug seeking behaviors and relapse in real environments but study on this notion is still limited. In this brief article, the authors review studies on cue-induced craving in human methamphetamine- dependent subjects in a laboratory-based approach. Craving for methamphetamine is elicited by a variety of methods in laboratory such as paraphernalia, verbal and visual cues and imaginary scripts. In this article, we review the studies applying different cues as main methods of craving incubation in laboratory settings. The brief reviewed literature provides strong evidence that craving for methamphetamine in laboratory conditions is significantly evoked by different cues. Cue-induced craving has important treatment and clinical implications for psychotherapists and clinicians when we consider the role of induced craving in evoking intense desire or urge to use methamphetamine after or during a period of successful craving prevention program. Elicited craving for methamphetamine in laboratory conditions is significantly influenced by methamphetamine-associated cues and results in rapid craving response toward methamphetamine use. This notion can be used as a main core for laboratory-based assessment of treatment efficacy for methamphetamine-dependent patients. In addition, the laboratory settings for studying craving can bridge the gap between somehow-non-reliable preclinical animal model studies and budget demanding randomized clinical trials.

  15. Methodological characteristics and treatment effect sizes in oral health randomised controlled trials: Is there a relationship? Protocol for a meta-epidemiological study.

    Science.gov (United States)

    Saltaji, Humam; Armijo-Olivo, Susan; Cummings, Greta G; Amin, Maryam; Flores-Mir, Carlos

    2014-02-25

    It is fundamental that randomised controlled trials (RCTs) are properly conducted in order to reach well-supported conclusions. However, there is emerging evidence that RCTs are subject to biases which can overestimate or underestimate the true treatment effect, due to flaws in the study design characteristics of such trials. The extent to which this holds true in oral health RCTs, which have some unique design characteristics compared to RCTs in other health fields, is unclear. As such, we aim to examine the empirical evidence quantifying the extent of bias associated with methodological and non-methodological characteristics in oral health RCTs. We plan to perform a meta-epidemiological study, where a sample size of 60 meta-analyses (MAs) including approximately 600 RCTs will be selected. The MAs will be randomly obtained from the Oral Health Database of Systematic Reviews using a random number table; and will be considered for inclusion if they include a minimum of five RCTs, and examine a therapeutic intervention related to one of the recognised dental specialties. RCTs identified in selected MAs will be subsequently included if their study design includes a comparison between an intervention group and a placebo group or another intervention group. Data will be extracted from selected trials included in MAs based on a number of methodological and non-methodological characteristics. Moreover, the risk of bias will be assessed using the Cochrane Risk of Bias tool. Effect size estimates and measures of variability for the main outcome will be extracted from each RCT included in selected MAs, and a two-level analysis will be conducted using a meta-meta-analytic approach with a random effects model to allow for intra-MA and inter-MA heterogeneity. The intended audiences of the findings will include dental clinicians, oral health researchers, policymakers and graduate students. The aforementioned will be introduced to the findings through workshops, seminars, round

  16. Orienteering club

    CERN Multimedia

    Club d'orientation

    2013-01-01

    Courses d’orientation Le soleil enfin de retour a incité nombre de sportifs et promeneurs à nous rejoindre dans la belle forêt de Challex /Pougny pour la deuxième étape de notre coupe de printemps 2013. Certains sont revenus crottés et fourbus alors que d’autres avaient les joues bien roses après un grand bol d’air frais. Mais tous avaient passé un agréable moment dans la nature. Nous rappelons que nos activités sont ouvertes à tous, jeunes, moins jeunes, sportifs, familles, du CERN ou d’ailleurs, et que le seul inconvénient est que si vous goûtez à la course d’orientation, il vous sera difficile de ne pas y revenir ! Samedi 20 avril 2013, nous serons sur le Mont Mourex (entre Gex et Divonne) pour notre prochaine épreuve et vous y serez les bienvenus. Les inscriptions et les départ...

  17. Orienteering club

    CERN Multimedia

    Club d’Orientation du CERN

    2015-01-01

    Courses d’orientation Nouvelle saison nouveau programme Le Club d’orientation du CERN, en partenariat avec d’autres clubs de la région, vous propose une dizaine de courses populaires comptant pour la coupe Genevoise de printemps: samedi 28 mars: Vernand Dessus samedi 18 avril: Pougny/Challex samedi 25 avril: Chancy/Valleiry samedi 2 mai: Mauvernay samedi 9 mai: Longchaumois samedi 16 mai: Genolier samedi 30 mai: Prevondavaux samedi 6 juin: Biere-Ballens samedi 13 juin: Haut-Jura samedi 20 juin: Bonmont - Finale Ces courses sont ouvertes à tous, quel que soit le niveau, du débutant au sportif confirmé, en famille ou en individuel, en promenade ou en course. Les inscriptions se font sur place le jour de l’épreuve. Si vous êtes débutant, vous pouvez profiter d’une initiation offerte par l’organisateur avant de vous lancer sur un parcours. Le club propose aussi...

  18. Orienteering club

    CERN Multimedia

    Orienteering Club

    2016-01-01

    Course d'orientation Calendrier des courses d’orientation Coupe genevoise d’automne 2016 Samedi 3 septembre : La Faucille (01) Samedi 10 septembre : Prémanon (39) Samedi 17 septembre : Saint-Cergue (VD) Samedi 24 septembre : Jorat / Corcelles (VD) Samedi 1 octobre: Bière - Ballens (VD) -relais Vendredi 14 octobre : Parc Mon Repos (GE) - nocturne Samedi 15 octobre : Terrasse de Genève (74) Samedi 29 octobre : Bonmont (VD) Samedi 5 novembre : Pomier (74) – one-man-relay - Finale   Courses ouvertes à toutes et à tous, sportifs, familles, débutants ou confirmés, du CERN ou d’ailleurs. Cinq circuits disponibles, ceci va du facile court (2 km) adapté aux débutants et aux enfants jusqu’au parcours technique long de 6 km pour les chevronnés en passant par les parcours facile moyen (4&am...

  19. COURSE ORIENTATION

    CERN Multimedia

    Club d'orientation du CERN

    2015-01-01

      Les coureurs d’orientation de la région se sont donné rendez-vous samedi dernier dans les bois de Pougny/Challex lors de l’épreuve organisée par le club d’orientation du CERN. La carte proposée pour les 5 circuits offrait aussi bien un coté très technique avec un relief pentu qu’un coté avec de grandes zones plates à forêt claire. Le parcours technique long comportant 20 postes a été remporté par Beat Muller du COLJ Lausanne en 56:26 devançant Denis Komarov, CO CERN en 57:30 et Yvan Balliot, ASO Annecy en 57:46. Pour les autres circuits les résultats sont les suivants: Technique moyen (13 postes): 1er Joël Mathieu en 52:32 à une seconde du 2e Vladimir Kuznetsov, COLJ Lausanne-Jorat, 3e Jean-Bernard Zosso, CO CERN, en 54:01 Technique court (12 postes): 1er Lennart Jirden, ...

  20. Orienteering Club

    CERN Multimedia

    Club d'Orientation

    2013-01-01

    Course d’orientation Face aux Championnats de France des Clubs à Poitiers, et à une météo hivernale (vent glaciale et pluie), il ne restait qu’une cinquantaine d’orienteurs pour participer à l’épreuve organisée le samedi 25 mai à Grange-Malval. Les participants ont tout de même bien apprécié les 5 circuits proposés par le Satus Genève. Les résultats sont disponibles sur notre site http://cern.ch/club-orientation. En plus des résultats, vous pourrez noter des informations sur la nouvelle école de CO encadrée par B. Barge, Prof. EPS à Ferney-Voltaire pour les jeunes à partir de 6 ans. La prochaine étape de la coupe genevoise se déroulera samedi 1er juin à Morez (39). Epreuve organisée par le club O’Jura&nb...

  1. Orienteering Club

    CERN Multimedia

    Le Club d’orientation du CERN

    2017-01-01

    COURSE ORIENTATION Finale de la coupe d’automne Le club d’orientation du CERN (COC Genève) a organisé sa dernière course populaire de la saison samedi 4 novembre au lieu-dit Les Terrasses de Genève (74). Cette 9e épreuve qui se courait sous la forme d’un One-Man-Relay, clôturait ainsi la coupe genevoise d’automne dont les lauréats sont : Circuit technique long : 1. Julien Vuitton (COC Genève), 2. Berni Wehrle (COC Genève), 3. Christophe Vuitton (COC Genève). Circuit technique moyen : 1. Vladimir Kuznetsov (Lausanne-Jorat), 2. J.-Bernard Zosso (COC Genève), 3. Laurent Merat (O’Jura). Circuit technique court : 1. Thibault Rouiller (COC Genève), 2. exæquo Lennart Jirden (COC Genève) et Katya Kuznetsova (Lausanne-Jorat). Circuit facile moyen : 1. Tituan Barge ...

  2. Orienteering Club

    CERN Multimedia

    Le Club d’orientation du CERN

    2017-01-01

    COURSE ORIENTATION Finale de la coupe d’automne Le club d’orientation du CERN (COC Genève) a organisé sa dernière course populaire de la saison samedi 4 novembre au lieu-dit Les Terrasses de Genève (74). Cette 9e épreuve qui se courait sous la forme d’un One-Man-Relay, clôturait ainsi la coupe genevoise d’automne dont les lauréats sont : Circuit technique long : 1. Julien Vuitton (COC Genève), 2. Berni Wehrle (COC Genève), 3. Christophe Vuitton (COC Genève). Circuit technique moyen : 1. Vladimir Kuznetsov (Lausanne-Jorat), 2. J.-Bernard Zosso (COC Genève), 3. Laurent Merat (O’Jura). Circuit technique court : 1. Thibault Rouiller (COC Genève), 2. exæquo Lennart Jirden (COC Genève) et Katya Kuznetsova (Lausanne-Jorat). Circuit facile moyen : 1. Tituan Barge...

  3. Orienteering Club

    CERN Multimedia

    Club d'Orientation

    2015-01-01

    Course orientation C’est au pied du Salève, proche du Golf de Bosset, que le club d’orientation du CERN (CO CERN) a organisé samedi 19 septembre une nouvelle épreuve comptant pour la Coupe Genevoise d’automne. La zone « des Terrasses de Genève » avait été cartographiée et mise en service l’année dernière. Les participants ont pu apprécier un terrain ludique avec beaucoup de microreliefs, de points d’eau et de gros rochers, le tout au milieu d’une forêt assez claire et agréable à courir. Sur le parcours technique long, le résultat a été très serré puisque Pierrick Merino du club d’Annecy a gagné avec seulement 9 secondes d’avance sur Gaëtan Vuitton (CO CERN) qui confiait avoir perdu beaucoup du te...

  4. Orienteering Club

    CERN Multimedia

    Le Club d’orientation du CERN

    2017-01-01

    Course orientation Les courses d’orientation comptant pour la coupe genevoise de printemps s’enchainent dans la région franco-suisse. Samedi dernier, une bonne centaine de coureurs se sont retrouvés au Mont Mourex où le club du CERN avait préparé la sixième épreuve. A l’issue de la course, les participants confirmaient l’exigence des circuits, à savoir la condition physique et le côté technique du traçage. Le parcours technique long comportant 20 postes a été remporté par Darrell High du Care Vevey en 1:22:38 devançant Beat Muller du COLJ Lausanne-Jorat en 1:25:25 et Alison High également du Care Vevey en 1:28:51. Le circuit technique moyen a été remporté par Christophe Vuitton du CO CERN et le circuit technique court par Claire-Lise Rouiller, CO CERN. Les trois pr...

  5. Orienteering Club

    CERN Multimedia

    Club d'orientation

    2010-01-01

    COURSE D’ORIENTATION La finale de la coupe de printemps Après avoir remporté le challenge club, samedi 29 juin lors du relais inter-club à Lausanne, le Club d’orientation du CERN organisait la dernière étape de la coupe genevoise de printemps samedi 5 juin à Saint-Cergue dans les bois de Monteret (Canton de Vaud). Plus de 100 participants se sont déplacés pour venir participer à la finale et découvrir une toute nouvelle carte dans une forêt vallonnée. Les résultats pour chaque circuit de cette étape sont : Technique long : 1. Jurg Niggli du club O’Jura, 2. Clément Poncet, 3. Oystein Midttun. Technique moyen : 1. Zoltan Trocsanyi CO CERN, 2. Christophe Ingold, 3. Christina Falga. Technique court : 1. Pierre-Andre Baum, CARE Vevey, 2. Emese Szunyog, 3. Solène Balay. Facile moyen : 1. Elisa P...

  6. Club Orientation

    CERN Multimedia

    Club d'orientation

    2014-01-01

      COURSE ORIENTATION   Pas moins de 100 concurrents sont venus s’affronter sur les parcours proposés par le club d’orientation du CERN ce samedi 26 avril lors de la 4e étape de la coupe genevoise de printemps. Les podiums ont été attribués à :  Technique long avec 19 postes : 1er Yvan Balliot, ASO Annecy en 1:01:39 ; 2e Dominique Fleurent, ASO Annecy, en 1:05:12 ; 3e Rémi Fournier, SOS Sallanches, en 1:05:40. Technique moyen avec 14 postes : 1er Jean-Bernard Zosso, CO CERN, en 46:42 ; 2e Céline Zosso, CO CERN, en 50:51 ; 3e Clément Poncet, O’Jura Prémanon, en 51:27. Technique court avec 13 postes : 1er Jaakko Murtomaki, YKV Seinaejoki, en 36:04 ; 2e Marc Baumgartner en 41:27 ; 3e Natalia Niggli, O’Jura Prémanon, en 52:43. Sur les parcours facile moyen et facile court, victoire respectivement de Stéphanie...

  7. Orienteering Club

    CERN Multimedia

    Le Club d’orientation du CERN

    2017-01-01

    Calendrier des courses de la Coupe Genevoise – printemps 2017 Club d'orientation - Julien,  jeune membre du club. Le Club d’orientation du CERN, en partenariat avec d’autres clubs de la région, vous propose une série de courses populaires, qui se dérouleront des deux côtés de la frontière franco-suisse, à savoir : Samedi 1 avril : Pougny/Challex (01) Samedi 8 avril: Ballens (VD) Samedi 22 avril: Apples (VD) Samedi 29 avril: Mont Mussy (01) Samedi 6 mai: Prémanon (39) Samedi 13 mai: Mont Mourex (01) Samedi 20 mai: Prévondavaux (VD) Samedi 10 juin: Chancy/Valleiry (74) Samedi 17 juin: Trélex - Finale (VD) Ces courses sont ouvertes à tous, quel que soit le niveau, du débutant au sportif confirmé, en famille ou en individuel. Les inscriptions sur un des 5 parcours proposés se font sur place le jour de l...

  8. An end-users oriented methodology for enhancing the integration of knowledge on soil-water-sediment systems in River Basin Management: an illustration from the AquaTerra project.

    Science.gov (United States)

    Merly, Corinne; Chapman, Antony; Mouvet, Christophe

    2012-01-01

    Research results in environmental and socio-economic sciences are often under-used by stakeholders involved in the management of natural resources. To minimise this gap, the FP6 EU interdisciplinary project AquaTerra (AT) developed an end-users' integration methodology in order to ensure that the data, knowledge and tools related to the soil-water-sediment system that were generated by the project were delivered in a meaningful way for end-users, thus improving their uptake. The methodology and examples of its application are presented in this paper. From the 408 project deliverables, 96 key findings were identified, 53 related to data and knowledge, and 43 describing advanced tools. River Basin Management (RBM) stakeholders workshops identified 8 main RBM issues and 25 specific stakeholders' questions related to RBM which were classified into seven groups of cross-cutting issues, namely scale, climate change, non-climatic change, the need for systemic approaches, communication and participation, international and inter-basin coordination and collaboration, and the implementation of the Water Framework Directive. The integration methodology enabled an assessment of how AT key findings meet stakeholders' demands, and for each main RBM issue and for each specific question, described the added-value of the AT project in terms of knowledge and tools generated, key parameters to consider, and recommendations that can be made to stakeholders and the wider scientific community. Added value and limitations of the integration methodology and its outcomes are discussed and recommendations are provided to further improve integration methodology and bridge the gaps between scientific research data and their potential uptake by end-users.

  9. Three Object-Oriented enhancement for EPICS

    Science.gov (United States)

    Osberg, E. A.; Dohan, D. A.; Richter, R.; Biggs, R.; Chillara, K.; Wade, D.; Bossom, J.

    1994-12-01

    In line with our group's intention of producing software using, where possible, Object-Oriented methodologies and techniques in the development of RF control systems, we have undertaken three projects to enhance the EPICS software environment. Two of the projects involve interfaces to EPICs Channel Access from Object-Oriented languages. The third is an enhancement to the EPICS State Notation Language to better support the Shlaer-Mellor Object-Oriented Analysis and Design Methodology. This paper discusses the motivation, approaches, results and future directions of these three projects.

  10. Soft Systems Methodology

    Science.gov (United States)

    Checkland, Peter; Poulter, John

    Soft systems methodology (SSM) is an approach for tackling problematical, messy situations of all kinds. It is an action-oriented process of inquiry into problematic situations in which users learn their way from finding out about the situation, to taking action to improve it. The learning emerges via an organised process in which the situation is explored using a set of models of purposeful action (each built to encapsulate a single worldview) as intellectual devices, or tools, to inform and structure discussion about a situation and how it might be improved. This paper, written by the original developer Peter Checkland and practitioner John Poulter, gives a clear and concise account of the approach that covers SSM's specific techniques, the learning cycle process of the methodology and the craft skills which practitioners develop. This concise but theoretically robust account nevertheless includes the fundamental concepts, techniques, core tenets described through a wide range of settings.

  11. On methodology

    DEFF Research Database (Denmark)

    Cheesman, Robin; Faraone, Roque

    2002-01-01

    This is an English version of the methodology chapter in the authors' book "El caso Berríos: Estudio sobre información errónea, desinformación y manipulación de la opinión pública".......This is an English version of the methodology chapter in the authors' book "El caso Berríos: Estudio sobre información errónea, desinformación y manipulación de la opinión pública"....

  12. Orienting hypnosis.

    Science.gov (United States)

    Hope, Anna E; Sugarman, Laurence I

    2015-01-01

    This article presents a new frame for understanding hypnosis and its clinical applications. Despite great potential to transform health and care, hypnosis research and clinical integration is impaired in part by centuries of misrepresentation and ignorance about its demonstrated efficacy. The authors contend that advances in the field are primarily encumbered by the lack of distinct boundaries and definitions. Here, hypnosis, trance, and mind are all redefined and grounded in biological, neurological, and psychological phenomena. Solutions are proposed for boundary and language problems associated with hypnosis. The biological role of novelty stimulating an orienting response that, in turn, potentiates systemic plasticity forms the basis for trance. Hypnosis is merely the skill set that perpetuates and influences trance. This formulation meshes with many aspects of Milton Erickson's legacy and Ernest Rossi's recent theory of mind and health. Implications of this hypothesis for clinical skills, professional training, and research are discussed.

  13. Oriented Approach

    Directory of Open Access Journals (Sweden)

    Seyed Mohammad Moghimi

    2013-12-01

    Full Text Available Promoting productivity is one of the goals of usinginformation technology in organizations. The purpose of this research isexamining the impact of IT on organizational productivity andrecognizing its mechanisms based on process-oriented approach. For thisend, by reviewing the literature of the subject a number of impacts of ITon organizational processes were identified. Then, through interviewswith IT experts, seven main factors were selected and presented in aconceptual model. This model was tested through a questionnaire in 148industrial companies. Data analysis shows that impact of IT onproductivity can be included in the eight major categories: Increasing ofthe Automation, Tracking, Communication, Improvement, Flexibility,Analytic, Coordination and Monitoring in organizational processes.Finally, to improve the impact of information technology onorganizational productivity, some suggestions are presented.

  14. EDITORIAL: Optical orientation Optical orientation

    Science.gov (United States)

    SAME ADDRESS *, Yuri; Landwehr, Gottfried

    2008-11-01

    priority of the discovery in the literature, which was partly caused by the existence of the Iron Curtain. I had already enjoyed contact with Boris in the 1980s when the two volumes of Landau Level Spectroscopy were being prepared [2]. He was one of the pioneers of magneto-optics in semiconductors. In the 1950s the band structure of germanium and silicon was investigated by magneto-optical methods, mainly in the United States. No excitonic effects were observed and the band structure parameters were determined without taking account of excitons. However, working with cuprous oxide, which is a direct semiconductor with a relative large energy gap, Zakharchenya and his co-worker Seysan showed that in order to obtain correct band structure parameters, it is necessary to take excitons into account [3]. About 1970 Boris started work on optical orientation. Early work by Hanle in Germany in the 1920s on the depolarization of luminescence in mercury vapour by a transverse magnetic field was not appreciated for a long time. Only in the late 1940s did Kastler and co-workers in Paris begin a systematic study of optical pumping, which led to the award of a Nobel prize. The ideas of optical pumping were first applied by Georges Lampel to solid state physics in 1968. He demonstrated optical orientation of free carriers in silicon. The detection method was nuclear magnetic resonance; optically oriented free electrons dynamically polarized the 29Si nuclei of the host lattice. The first optical detection of spin orientation was demonstrated by with the III-V semiconductor GaSb by Parsons. Due to the various interaction mechanisms of spins with their environment, the effects occurring in semiconductors are naturally more complex than those in atoms. Optical detection is now the preferred method to detect spin alignment in semiconductors. The orientation of spins in crystals pumped with circularly polarized light is deduced from the degree of circular polarization of the recombination

  15. Orienteering Club

    CERN Multimedia

    Club d'orientation

    2013-01-01

    Course d'orientation Le coup d’envoi de la coupe genevoise a été donné samedi 31 août dans les bois de Combe Froide à Prémanon. Plus de 150 coureurs avaient fait le déplacement. Les parcours facile court, facile moyen et technique court ont été remportés par des coureurs du club O’Jura - Ulysse Dannecker, Léo Lonchampt, Franck Lonchampt, le technique moyen par Pekka Marti du club Ol Biel Seeland et le technique long par Térence Risse du CA Rosé – également membre de l’équipe nationale suisse des moins de 20 ans. Pour le club du CERN, les meilleures résultats ont été obtenus pas Emese Szunyog sur technique court et Marie Vuitton sur technique moyen avec une 4e place. La prochaine course aura lieu samedi 14 septembre à La Faucille. Le club propose aussi...

  16. Orienteering club

    CERN Multimedia

    Club d'orientation

    2014-01-01

    Course d'orientation Finale de la coupe d’automne La dernière épreuve de la coupe d’automne organisée par le club s’est déroulée ce samedi 1er novembre avec une course type «one-man-relay» dans la forêt de Trelex (Vd). Les concurrents des circuits techniques devaient parcourir trois boucles et ceux des circuits «faciles» deux boucles, avec changements de carte. Le parcours technique long a été remporté par un membre du club, Berni Wehrle. A l’issue de cette course, le Président du club, L. Jirden annonçait le classement général de la coupe d’automne, basé sur les 6 meilleurs résultats de la saison : Circuit technique long : 1er Juerg Niggli (O’Jura), 2e Berni Wehrle, 3e Beat Mueller. Circuit technique moyen : 1er Laurent Merat (O&r...

  17. Orienteering club

    CERN Multimedia

    Club d'orientation

    2013-01-01

    Course d'orientation Finale de la coupe genevoise Rapide et méthodique, voilà les qualités dont il fallait faire preuve pour remporter la dernière étape de la coupe organisée par le club du CERN dans les bois de Monteret. Il s’agissait d’une course au score où chaque concurrent disposait d’un temps imparti pour poinçonner le maximum de balises. Le parcours technique a été remporté par Tomas Shellman et le parcours facile par Victor Dannecker. Cette dernière étape était aussi décisive pour la désignation des lauréats de la coupe genevoise de printemps. Les résultats officiels étaient donnés par le président du club, L. Jirden : Circuit Technique Long : Berni Wehrle, Bruno Barge, Edvins Reisons Circuit Technique Moyen : J.-Bernard Zosso, ...

  18. Orienteering Club

    CERN Multimedia

    Club d'Orientation

    2011-01-01

    Course d'orientation Avec la CO en nocturne organisée par le club du CERN vendredi 14 octobre au stade des Eveaux (Ge), et la CO à Savigny (Vd) proposée par le club de Lausanne-Jorat le lendemain, les étapes de la coupe genevoise d’automne s’enchainent rapidement. Il ne reste plus que 3 rendez-vous pour boucler la saison. Les premières places devraient certainement se jouer entre des membres du club du CERN, du O’Jura ou de Lausanne-Jorat. La prochaine course du club est programmée pour samedi 22 octobre à Pomier, près de Cruseilles. L’accueil se fera à partir de 12h30 et les départs s’échelonneront de 13h à 15h. * * * * * * * Nouvelle belle victoire samedi 8 octobre à Saint Cergue du jeune finlandais Ville Keskisaari (COLJ) en 50:56 devant Jürg Niggli (O’Jura) en 1:03:32, et Alexandre...

  19. Orienteering Club

    CERN Document Server

    Club d'orientation

    2013-01-01

    De jour comme de nuit Les amateurs de course d’orientation ont pu s’en donner à cœur joie ce week-end puisqu’ils avaient la possibilité de courir sur deux épreuves en moins de 24 heures. En effet, le club du CERN organisait une course de nuit aux Evaux et la 7e étape de la coupe genevoise se tenait samedi après-midi dans les bois du Grand Jorat à Savigny. Les vainqueurs pour chaque course sont : Technique long CO de nuit: Julien Charlemagne, SOS Sallanches CO samedi: Philipp Khlebnikov, ANCO   Technique moyen CO de nuit: Céline Zosso, CO CERN CO samedi: Pavel Khlebnikov, ANCO Technique court CO de nuit: Colas Ginztburger, SOS Sallanches CO samedi: Victor Kuznetsov, COLJ Lausannne Facile moyen CO de nuit: Gaëtan Rickenbacher, CO CERN CO samedi: Tamas Szoke   Facile court CO de nuit:Oriane Rickenbacher, CO CERN CO samedi: Katya Kuznetsov...

  20. Orienteering Club

    CERN Multimedia

    Club d'Orientation

    2015-01-01

    Course orientation Finale de la coupe genevoise La série des courses de printemps s’est achevée samedi dernier dans les bois de Bonmont (Vaud) avec une épreuve «one-man-relay» organisée par le club. Le vainqueur du parcours technique  long, Yann Locatelli (Club de Chambéry Savoie) a réalisé les deux boucles comportant 24 balises avec presque 6 minutes d’avance sur le second concurrent Domenico Lepori (Club CARE Vevey). Cette dernière étape était aussi décisive pour la désignation des lauréats de la coupe genevoise de printemps, en comptabilisant les 6 meilleurs résultats sur les 10 épreuves. Le podium officiel était donné par le président du club, L. Jirden, qui profitait de l’occasion pour remercier tous les participants et également tous les...

  1. Orienteering Club

    CERN Multimedia

    CLUB D'ORIENTATION

    2013-01-01

    Calendrier de la coupe d’automne Le Club d’orientation du CERN, en partenariat avec d’autres clubs de la région, vous propose, pour cette nouvelle coupe d’automne genevoise, une série de 10 courses. Le club du O’Jura donnera le coup d’envoi le samedi 31 août. Les courses s’enchaîneront selon le calendrier suivant : Samedi 31 août : Prémanon (39) - longue distance Samedi 14 septembre : La Faucille (01) - longue distance Samedi 21 septembre : Saint Cergue (VD) - longue distance Samedi 28 septembre : Ballens (VD) - relais Samedi 5 octobre : La Pile (VD) - longue distance Vendredi 11 octobre : Les Evaux (GE) - nocturne Samedi 12 octobre : Grand Jorat, Savigny (VD) - longue distance Samedi 19 octobre : Terrasses de Genève (74) - longue distance Samedi 26 octobre : Prémanon (39) - longue distance Samedi 2 novembre : Bois Tollot (GE) - score - Finale Les &a...

  2. Orienteering club

    CERN Multimedia

    Club d'orientation

    2014-01-01

    Course d'orientation C’est sous un beau soleil samedi 4 octobre que s’est déroulée la 6e étape de la Coupe genevoise d’automne organisée par le club. Plus d’une centaine de concurrents provenant de 7 clubs de CO avaient fait le déplacement pour courir sur un des cinq parcours proposés dans les bois de Trélex-Génolier (VD). Le podium est le suivant : Technique long (5,9 km, 19 postes) : 1er Jurg Niggli, O’Jura (1:00:02); 2e Berni Wehrle, CO CERN (1:06:44); 3e Konrad Ehrbar, COLJ (1:07:08) Technique moyen (4,8 km, 18 postes) : 1er Christophe Vuitton, CO CERN (54:25); 2e J.B. Zosso, CO CERN (1:01:19); 3e Jeremy Wichoud, COLJ (1:06:21) Technique court (3,8 km, 14 postes) : 1er Julien Vuitton, CO CERN (36:19); 2e Vladimir Kuznetsov, COLJ (48:47); 3e Natalia Niggli, O’Jura (50:38) Facile moyen (3,2 km, 11 postes) : 1ère Alina Niggli, O&...

  3. Orienteering Club

    CERN Multimedia

    Club d'Orientation

    2012-01-01

    Relais inter-club/Challenge Carlo Milan Samedi dernier, lors de l’épreuve de course d’orientation organisée par le club du O’Jura, le moteur de la discipline était l’esprit d’équipe, puisqu’il était question d’un relais inter-club avec le Challenge Carlo Milan. Les clubs avaient aligné leurs coureurs soit sur le relais technique (trois participants) soit sur le relais facile (deux participants). Côté O’Jura, il fallait noter la participation de François Gonon, champion du monde 2011, côté club du CERN, Marie et Gaëtan Vuitton, jeunes espoirs du club, devaient préparer la piste pour lancer le dernier relayeur. Côté Lausanne-Jorat, il fallait compter sur le très jeune Viktor Kuznetsov. Les 31 équipes engagées n’ont pas m&ea...

  4. Orienteering Club

    CERN Multimedia

    Club d'Orientation

    2012-01-01

     Finale de la coupe de printemps   La dernière course d’orientation comptant pour la Coupe de printemps a eu lieu samedi dernier dans le village des Rousses et vers le Fort. Il s’agissait d’un sprint organisé par le club O’Jura. Les temps de course ont avoisiné les 20 minutes que ce soit pour le parcours technique moyen ou technique long. Tous les habitués étaient au rendez-vous pour venir consolider ou améliorer leur place au classement. A l’issue de cette course, le classement général de la Coupe de printemps prenant en compte les 6 meilleurs résultats des 9 courses était établi et les lauréats de chaque catégorie sont les suivants: Circuit technique long : 1er Berni Wehrle, 2e Bruno Barge, 3e Edvins Reisons. Circuit technique moyen : 1er Jean-Bernard Zosso, 2e Cédric Wehrl&...

  5. Orienteering club

    CERN Multimedia

    Club d'orientation

    2010-01-01

    COURSE D’ORIENTATION  De La Rippe à Sauvabellin, la coupe genevoise continue ! Le rendez-vous était donné samedi 8 mai aux amateurs de course d’orientation dans les bois de La Rippe (Canton de Vaud). Cette 6e épreuve était organisée par le Club Satus Grutli de Genève. Il est dommage que les participants n’aient pas été aussi nombreux que lors des dernières courses, les Championnats de France des clubs à Dijon ayant certainement retenus plus d’un compétiteur. La première place est revenue à : – Technique long : Berni Wehrle – Technique moyen : Jean-Bernard Zosso – Technique court : Berni Wehrle – Facile moyen : Peter Troscanyi – Facile court : Claire Droz. Il ne restera plus que deux épreuves ...

  6. Orienteering club

    CERN Multimedia

    Club d'orientation

    2013-01-01

    Courses d’orientation Samedi 20 avril, les organisateurs du Club de CO du CERN ont accueilli au Mont Mourex 70 participants qui n’ont pas hésité à venir malgré la forte bise. Berni Wehrle du CO CERN s’est octroyé la première place en 1:04:49 sur le parcours technique long devant Pyry Kettunen du Saynso Juankoski en 1:06:52, la 3e place revenant à Bruno Barge, CO CERN, à 7 secondes. Les autres parcours ont été remportés par : Technique moyen : 1er Jacques Moisset, Chamonix (47:44), 2e Yves Rousselot, Balise 25 Besançon (57:16), 3e Jean-Bernard Zosso, CO CERN (59:28). Technique court : 1er Victor Kuznetsov, COLJ (51:53), 2e Pierrick Collet, CO CERN (1:12:52), 3e Dominique Balay, CO CERN (1:16:04). Pour les parcours facile moyen et facile court, Ralf Nardini et Léa Nicolas, tous deux du CO CERN, terminaient respectivement premier. Voi...

  7. The development of a 4D treatment planning methodology to simulate the tracking of central lung tumors in an MRI-linac.

    Science.gov (United States)

    Al-Ward, Shahad M; Kim, Anthony; McCann, Claire; Ruschin, Mark; Cheung, Patrick; Sahgal, Arjun; Keller, Brian M

    2018-01-01

    Targeting and tracking of central lung tumors may be feasible on the Elekta MRI-linac (MRL) due to the soft-tissue visualization capabilities of MRI. The purpose of this work is to develop a novel treatment planning methodology to simulate tracking of central lung tumors with the MRL and to quantify the benefits in OAR sparing compared with the ITV approach. Full 4D-CT datasets for five central lung cancer patients were selected to simulate the condition of having 4D-pseudo-CTs derived from 4D-MRI data available on the MRL with real-time tracking capabilities. We used the MRL treatment planning system to generate two plans: (a) with a set of MLC-defined apertures around the target at each phase of the breathing ("4D-MRL" method); (b) with a fixed set of fields encompassing the maximum inhale and exhale of the breathing cycle ("ITV" method). For both plans, dose accumulation was performed onto a reference phase. To further study the potential benefits of a 4D-MRL method, the results were stratified by tumor motion amplitude, OAR-to-tumor proximity, and the relative OAR motion (ROM). With the 4D-MRL method, the reduction in mean doses was up to 3.0 Gy and 1.9 Gy for the heart and the lung. Moreover, the lung's V12.5 Gy was spared by a maximum of 300 cc. Maximum doses to serial organs were reduced by up to 6.1 Gy, 1.5 Gy, and 9.0 Gy for the esophagus, spinal cord, and the trachea, respectively. OAR dose reduction with our method depended on the tumor motion amplitude and the ROM. Some OARs with large ROMs and in close proximity to the tumor benefited from tracking despite small tumor amplitudes. We developed a novel 4D tracking methodology for the MRL for central lung tumors and quantified the potential dosimetric benefits compared with our current ITV approach. © 2017 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

  8. Methodological guidelines

    International Nuclear Information System (INIS)

    Halsnaes, K.; Callaway, J.M.; Meyer, H.J.

    1999-01-01

    The guideline document establishes a general overview of the main components of climate change mitigation assessment. This includes an outline of key economic concepts, scenario structure, common assumptions, modelling tools and country study assumptions. The guidelines are supported by Handbook Reports that contain more detailed specifications of calculation standards, input assumptions and available tools. The major objectives of the project have been provided a methodology, an implementing framework and a reporting system which countries can follow in meeting their future reporting obligations under the FCCC and for GEF enabling activities. The project builds upon the methodology development and application in the UNEP National Abatement Coasting Studies (UNEP, 1994a). The various elements provide countries with a road map for conducting climate change mitigation studies and submitting national reports as required by the FCCC. (au) 121 refs

  9. Methodological guidelines

    Energy Technology Data Exchange (ETDEWEB)

    Halsnaes, K.; Callaway, J.M.; Meyer, H.J.

    1999-04-01

    The guideline document establishes a general overview of the main components of climate change mitigation assessment. This includes an outline of key economic concepts, scenario structure, common assumptions, modelling tools and country study assumptions. The guidelines are supported by Handbook Reports that contain more detailed specifications of calculation standards, input assumptions and available tools. The major objectives of the project have been provided a methodology, an implementing framework and a reporting system which countries can follow in meeting their future reporting obligations under the FCCC and for GEF enabling activities. The project builds upon the methodology development and application in the UNEP National Abatement Coasting Studies (UNEP, 1994a). The various elements provide countries with a road map for conducting climate change mitigation studies and submitting national reports as required by the FCCC. (au) 121 refs.

  10. [Systematic review on methodology of randomized controlled trials of post-marketing Chinese patent drugs for treatment of type 2 diabetes].

    Science.gov (United States)

    Ma, Li-xin; Wang, Yu-yi; Li, Xin-xue; Liu, Jian-ping

    2012-03-01

    Randomized controlled trial (RCT) is considered as the gold standard for the efficacy assessment of medicines. With the increasing number of Chinese patent drugs for treatment of type 2 diabetes, the methodology of post-marketing RCTs evaluating the efficacy and specific effect has become more important. To investigate post-marketing Chinese patent drugs for treatment of type 2 diabetes, as well as the methodological quality of post-marketing RCTs. Literature was searched from the books of Newly Compiled Traditional Chinese Patent Medicine and Chinese Pharmacopeia, the websites of the State Food and Drug Administration and the Ministry of Human Resources and Social Security of the People's Republic of China, China National Knowledge Infrastructure Database, Chongqing VIP Chinese Science and Technology Periodical Database, Chinese Biomedical Database (SinoMed) and Wanfang Data. The time period for searching ran from the commencement of each database to August 2011. RCTs of post-marketing Chinese patent drugs for treatment of type 2 diabetes with intervention course no less than 3 months. Two authors independently evaluated the research quality of the RCTs by the checklist of risk bias assessment and the data collection forms based on the CONSORT Statement. Independent double data-extraction was performed. The authors identified a total of 149 Chinese patent drugs for treatment of type 2 diabetes. According to different indicative syndromes, the Chinese patent drugs can be divided into the following types, namely, yin deficiency and interior heat (n=48, 32%), dual deficiency of qi and yin (n=58, 39%) and dual deficiency of qi and yin combined with blood stasis (n=22, 15%). A total of 41 RCTs meeting the inclusion criteria were included. Neither multicenter RCTs nor endpoint outcome reports were found. Risk bias analysis showed that 81% of the included studies reported randomization for grouping without sequence generation, 98% of these studies did not report

  11. Application of Response Surface Methodology for Modeling of Postweld Heat Treatment Process in a Pressure Vessel Steel ASTM A516 Grade 70.

    Science.gov (United States)

    Peasura, Prachya

    2015-01-01

    This research studied the application of the response surface methodology (RSM) and central composite design (CCD) experiment in mathematical model and optimizes postweld heat treatment (PWHT). The material of study is a pressure vessel steel ASTM A516 grade 70 that is used for gas metal arc welding. PWHT parameters examined in this study included PWHT temperatures and time. The resulting materials were examined using CCD experiment and the RSM to determine the resulting material tensile strength test, observed with optical microscopy and scanning electron microscopy. The experimental results show that using a full quadratic model with the proposed mathematical model is YTS = -285.521 + 15.706X1 + 2.514X2 - 0.004X1(2) - 0.001X2(2) - 0.029X1X2. Tensile strength parameters of PWHT were optimized PWHT time of 5.00 hr and PWHT temperature of 645.75°C. The results show that the PWHT time is the dominant mechanism used to modify the tensile strength compared to the PWHT temperatures. This phenomenon could be explained by the fact that pearlite can contribute to higher tensile strength. Pearlite has an intensity, which results in increased material tensile strength. The research described here can be used as material data on PWHT parameters for an ASTM A516 grade 70 weld.

  12. Effect of cold plasma pre-treatment on photocatalytic activity of 3D fabric loaded with nano-photocatalysts: Response surface methodology

    Science.gov (United States)

    Ghoreishian, Seyed Majid; Badii, Khashayar; Norouzi, Mohammad; Malek, Kaveh

    2016-03-01

    In this study, the physico-chemical effects occasioned by the cold plasma discharge (CPD) on the photo-decolorization of Reactive Orange 16 (RO16) by 3D fabrics (spacer fabrics) loaded with ZnO:TiO2 nano-photocatalysts (nphs) were optimized via response surface methodology (RSM). CPD was employed to improve the surface characteristics of the spacer fabrics for nphs loading. Surface morphology and color variation were studied utilizing scanning electron microscopy (SEM) and CIE-Lab system, respectively. The effect of CPD on the wetting ability of the spacer fabrics was examined using dynamic adsorption measurement (DAM). Also, X-ray fluorescence (XRF) was utilized to investigate the durability of the nphs on the spacer fabrics. All the experiments were implemented in a Box-Behnken design (BBD) with three independent variables (CPD treatment time, dye concentration and irradiation time) in order to optimize the decolorization of RO16. The anticipated values of the decolorization efficiency were found to be in excellent agreement with the experimental values (R2 = 0.9996, Adjusted R2 = 0.9992). The kinetic analysis demonstrated that the photocatalytic decolorization followed the Langmuir-Hinshelwood kinetic model. In conclusion, this heterogeneous photocatalytic process is capable of decolorizing and mineralizing azoic reactive dye in textile wastewater. Moreover, the results confirmed that RSM based on the BBD was a suitable method to optimize the operating conditions of RO16 degradation.

  13. Combined treatment of Thymus vulgaris L., Rosmarinus officinalis L. and Myrtus communis L. essential oils against Salmonella typhimurium: Optimization of antibacterial activity by mixture design methodology.

    Science.gov (United States)

    Fadil, Mouhcine; Fikri-Benbrahim, Kawtar; Rachiq, Saad; Ihssane, Bouchaib; Lebrazi, Sara; Chraibi, Marwa; Haloui, Taoufik; Farah, Abdellah

    2018-05-01

    To increase the sensibility of Salmonella typhimurium strain, a mixture of Thymus vulgaris L. (T. vulgaris L.), Rosmarinus officinalis L. (R. officinalis L.) and Myrtus communis L. (M. communis L.) essential oils (EOs) was used in combined treatment by experimental design methodology (mixture design). The chemical composition of EOs was firstly identified by GC and GC/MS and their antibacterial activity was evaluated. The results of this first step have shown that thymol and borneol were the major compounds in T. vulgaris and M. communis L. EOs, respectively, while 1,8-cineole and α-pinene were found as major compounds in R. officinalis L. The same results have shown a strong antibacterial activity of T. vulgaris L. EO followed by an important power of M. communis L. EO against a moderate activity of R. officinalis L. EO. Besides, 1/20 (v/v) was the concentration giving a strain response classified as sensitive. From this concentration, the mixture design was performed and analyzed. The optimization of mixtures antibacterial activities has highlighted the synergistic effect between T. vulgaris L. and M. communis L. essential oils. A formulation comprising 55% of T. vulgaris L. and 45% of M. communis L. essential oils, respectively, can be considered for the increase of Salmonella typhimurium sensibility. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. A methodological framework for assessing agreement between cost-effectiveness outcomes estimated using alternative sources of data on treatment costs and effects for trial-based economic evaluations.

    Science.gov (United States)

    Achana, Felix; Petrou, Stavros; Khan, Kamran; Gaye, Amadou; Modi, Neena

    2018-01-01

    A new methodological framework for assessing agreement between cost-effectiveness endpoints generated using alternative sources of data on treatment costs and effects for trial-based economic evaluations is proposed. The framework can be used to validate cost-effectiveness endpoints generated from routine data sources when comparable data is available directly from trial case report forms or from another source. We illustrate application of the framework using data from a recent trial-based economic evaluation of the probiotic Bifidobacterium breve strain BBG administered to babies less than 31 weeks of gestation. Cost-effectiveness endpoints are compared using two sources of information; trial case report forms and data extracted from the National Neonatal Research Database (NNRD), a clinical database created through collaborative efforts of UK neonatal services. Focusing on mean incremental net benefits at £30,000 per episode of sepsis averted, the study revealed no evidence of discrepancy between the data sources (two-sided p values >0.4), low probability estimates of miscoverage (ranging from 0.039 to 0.060) and concordance correlation coefficients greater than 0.86. We conclude that the NNRD could potentially serve as a reliable source of data for future trial-based economic evaluations of neonatal interventions. We also discuss the potential implications of increasing opportunity to utilize routinely available data for the conduct of trial-based economic evaluations.

  15. Sexual Orientation (For Parents)

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Sexual Orientation KidsHealth / For Parents / Sexual Orientation What's in this ... orientation is part of that process. What Is Sexual Orientation? The term sexual orientation refers to the gender ( ...

  16. MIRD methodology

    International Nuclear Information System (INIS)

    Rojo, Ana M.; Gomez Parada, Ines

    2004-01-01

    The MIRD (Medical Internal Radiation Dose) system was established by the Society of Nuclear Medicine of USA in 1960 to assist the medical community in the estimation of the dose in organs and tissues due to the incorporation of radioactive materials. Since then, 'MIRD Dose Estimate Report' (from the 1 to 12) and 'Pamphlets', of great utility for the dose calculations, were published. The MIRD system was planned essentially for the calculation of doses received by the patients during nuclear medicine diagnostic procedures. The MIRD methodology for the absorbed doses calculations in different tissues is explained

  17. PSA methodology

    Energy Technology Data Exchange (ETDEWEB)

    Magne, L

    1997-12-31

    The purpose of this text is first to ask a certain number of questions on the methods related to PSAs. Notably we will explore the positioning of the French methodological approach - as applied in the EPS 1300{sup 1} and EPS 900{sup 2} PSAs - compared to other approaches (Part One). This reflection leads to more general reflection: what contents, for what PSA? This is why, in Part Two, we will try to offer a framework for definition of the criteria a PSA should satisfy to meet the clearly identified needs. Finally, Part Three will quickly summarize the questions approached in the first two parts, as an introduction to the debate. 15 refs.

  18. PSA methodology

    International Nuclear Information System (INIS)

    Magne, L.

    1996-01-01

    The purpose of this text is first to ask a certain number of questions on the methods related to PSAs. Notably we will explore the positioning of the French methodological approach - as applied in the EPS 1300 1 and EPS 900 2 PSAs - compared to other approaches (Part One). This reflection leads to more general reflection: what contents, for what PSA? This is why, in Part Two, we will try to offer a framework for definition of the criteria a PSA should satisfy to meet the clearly identified needs. Finally, Part Three will quickly summarize the questions approached in the first two parts, as an introduction to the debate. 15 refs

  19. Advances in oriental document analysis and recognition techniques

    CERN Document Server

    Lee, Seong-Whan

    1999-01-01

    In recent years, rapid progress has been made in computer processing of oriental languages, and the research developments in this area have resulted in tremendous changes in handwriting processing, printed oriental character recognition, document analysis and recognition, automatic input methodologies for oriental languages, etc. Advances in computer processing of oriental languages can also be seen in multimedia computing and the World Wide Web. Many of the results in those domains are presented in this book.

  20. Optimization of the electro-Fenton and solar photoelectro-Fenton treatments of sulfanilic acid solutions using a pre-pilot flow plant by response surface methodology

    International Nuclear Information System (INIS)

    El-Ghenymy, Abdellatif; Garcia-Segura, Sergi; Rodríguez, Rosa María; Brillas, Enric; El Begrani, Mohamed Soussi; Abdelouahid, Ben Ali

    2012-01-01

    Highlights: ► Quicker degradation of sulfanilic acid by solar photoelectro-Fenton than electro-Fenton. ► The same optimized current density, Fe 2+ content and pH for both processes by CCRD. ► Description of TOC, energy cost and current efficiency by response surface methodology. ► Fe(III)–carboxylate complexes as main by-products after electro-Fenton. ► Photolysis of these complexes by UV irradiation of sunlight in solar photoelectro-Fenton. - Abstract: A central composite rotatable design and response surface methodology were used to optimize the experimental variables of the electro-Fenton (EF) and solar photoelectro-Fenton (SPEF) degradations of 2.5 L of sulfanilic acid solutions in 0.05 M Na 2 SO 4 . Electrolyses were performed with a pre-pilot flow plant containing a Pt/air diffusion reactor generating H 2 O 2 . In SPEF, it was coupled with a solar photoreactor under an UV irradiation intensity of ca. 31 W m −2 . Optimum variables of 100 mA cm −2 , 0.5 mM Fe 2+ and pH 4.0 were determined after 240 min of EF and 120 min of SPEF. Under these conditions, EF gave 47% of mineralization, whereas SPEF was much more powerful yielding 76% mineralization with 275 kWh kg −1 total organic carbon (TOC) energy consumption and 52% current efficiency. Sulfanilic acid decayed at similar rate in both treatments following a pseudo-first-order kinetics. The final solution treated by EF contained a stable mixture of tartaric, acetic, oxalic and oxamic acids, which form Fe(III) complexes that are not attacked by hydroxyl radicals formed from H 2 O 2 and added Fe 2+ . The quick photolysis of these complexes by UV light of sunlight explains the higher oxidation power of SPEF. NH 4 + was the main inorganic nitrogen ion released in both processes.

  1. A pilot double-blind, randomized, placebo-controlled trial of the efficacy of trace elements in the treatment of endometriosis-related pain: study design and methodology

    Directory of Open Access Journals (Sweden)

    Oberweis D

    2016-02-01

    Full Text Available Didier Oberweis,1 Patrick Madelenat,2 Michelle Nisolle,3 Etienne Demanet4 1Department of Gynecology and Obstetrics, CHU de Charleroi, Hôpital André Vésale, Montigny-le-Tilleul, Belgium; 2Private Consultation, Paris, France; 3Department of Gynecology and Obstetrics, CHR Citadelle, Liège, 4Clinical Research Unit, Charleroi, Belgium Abstract: Endometriosis is one of the most common benign gynecological disorders, affecting almost 10%–15% of all women of reproductive age and >30% of infertile women. The pathology is associated with various distressing symptoms, particularly pelvic pain, which adversely affect patients' quality of life. It is an estrogen-dependent disease. There is evidence both in animals and in humans that metal ions can activate the estrogen receptors. They are defined as a variety of xenoestrogens, called metalloestrogens, which could act as endocrine disruptors. Therefore, it could be considered to act on this gynecological disorder using food supplements containing trace elements (ie, nutripuncture. The assumption is that they could modulate estrogen receptors and thus influence the tropism and the survival of cells involved in endometriosis. By a modulation of the antioxidant system, they might also interact with various parameters influencing tissue biochemistry. The objective of this article is to describe and discuss the design and methodology of an ongoing double-blind, randomized, placebo-controlled study aiming to evaluate the efficacy of metal trace elements on the reduction of pain and improvement of quality of life, in patients with a revised American Fertility Society Score Stages II–IV endometriosis, combined or not with adenomyosis, during a treatment period of 4 months. Trace elements or placebo is proposed in the absence of any other treatment or as an add-on to current therapies, such as sexual hormones, nonsteroidal anti-inflammatory drugs, and surgery. A placebo run-in period of one menstrual cycle or

  2. A mathematical theory of shape and neuro-fuzzy methodology-based diagnostic analysis: a comparative study on early detection and treatment planning of brain cancer.

    Science.gov (United States)

    Kar, Subrata; Majumder, D Dutta

    2017-08-01

    hidden layer of 10 neurons and 2 output neurons. Of the 16-sample database, 10 datasets for training, 3 datasets for validation, and 3 datasets for testing were used in the ANN classification system. From the SSM (µ) confusion matrix, the number of output datasets of true positive, false positive, true negative and false negative was 6, 0, 10, and 0, respectively. The sensitivity, specificity and accuracy were each equal to 100%. The method of diagnosing brain cancer presented in this study is a successful model to assist doctors in the screening and treatment of brain cancer patients. The presented FES successfully identified the presence of brain cancer in CT and MR images using the extracted shape-based features and the use of NFS for the identification of brain cancer in the early stages. From the analysis and diagnosis of the disease, the doctors can decide the stage of cancer and take the necessary steps for more accurate treatment. Here, we have presented an investigation and comparison study of the shape-based feature extraction method with the use of NFS for classifying brain tumors as showing normal or abnormal patterns. The results have proved that the shape-based features with the use of NFS can achieve a satisfactory performance with 100% accuracy. We intend to extend this methodology for the early detection of cancer in other regions such as the prostate region and human cervix.

  3. Effect of cold plasma pre-treatment on photocatalytic activity of 3D fabric loaded with nano-photocatalysts: Response surface methodology

    International Nuclear Information System (INIS)

    Ghoreishian, Seyed Majid; Badii, Khashayar; Norouzi, Mohammad; Malek, Kaveh

    2016-01-01

    Graphical abstract: - Highlights: • The potential of immobilized TiO_2 and ZnO nanophotocatalysts for the removal of reactive dye was investigated. • Optimum decolorization conditions have been determined. • The immobilized nanophotocatalysts decolorized azo dyes completely from a textile effluent within 60 min. • Photocatalytic decolorization rates obeyed the pseudo-first-order rate. - Abstract: In this study, the physico-chemical effects occasioned by the cold plasma discharge (CPD) on the photo-decolorization of Reactive Orange 16 (RO16) by 3D fabrics (spacer fabrics) loaded with ZnO:TiO_2 nano-photocatalysts (nphs) were optimized via response surface methodology (RSM). CPD was employed to improve the surface characteristics of the spacer fabrics for nphs loading. Surface morphology and color variation were studied utilizing scanning electron microscopy (SEM) and CIE-Lab system, respectively. The effect of CPD on the wetting ability of the spacer fabrics was examined using dynamic adsorption measurement (DAM). Also, X-ray fluorescence (XRF) was utilized to investigate the durability of the nphs on the spacer fabrics. All the experiments were implemented in a Box–Behnken design (BBD) with three independent variables (CPD treatment time, dye concentration and irradiation time) in order to optimize the decolorization of RO16. The anticipated values of the decolorization efficiency were found to be in excellent agreement with the experimental values (R"2 = 0.9996, Adjusted R"2 = 0.9992). The kinetic analysis demonstrated that the photocatalytic decolorization followed the Langmuir–Hinshelwood kinetic model. In conclusion, this heterogeneous photocatalytic process is capable of decolorizing and mineralizing azoic reactive dye in textile wastewater. Moreover, the results confirmed that RSM based on the BBD was a suitable method to optimize the operating conditions of RO16 degradation.

  4. Effect of cold plasma pre-treatment on photocatalytic activity of 3D fabric loaded with nano-photocatalysts: Response surface methodology

    Energy Technology Data Exchange (ETDEWEB)

    Ghoreishian, Seyed Majid, E-mail: m.ghoreishian.1985@gmail.com [Young Researchers and Elite Club, South Tehran Branch, Islamic Azad University, Tehran (Iran, Islamic Republic of); Badii, Khashayar [Department of Environmental Researches, Institute for Color Science and Technology (ICST), Tehran (Iran, Islamic Republic of); Norouzi, Mohammad [Graduate Program of Biomedical Engineering, University of Manitoba, Winnipeg, MB (Canada); Malek, Kaveh [Department of Mechanical Engineering, Science and Research Branch, Islamic Azad University, Tehran (Iran, Islamic Republic of)

    2016-03-01

    Graphical abstract: - Highlights: • The potential of immobilized TiO{sub 2} and ZnO nanophotocatalysts for the removal of reactive dye was investigated. • Optimum decolorization conditions have been determined. • The immobilized nanophotocatalysts decolorized azo dyes completely from a textile effluent within 60 min. • Photocatalytic decolorization rates obeyed the pseudo-first-order rate. - Abstract: In this study, the physico-chemical effects occasioned by the cold plasma discharge (CPD) on the photo-decolorization of Reactive Orange 16 (RO16) by 3D fabrics (spacer fabrics) loaded with ZnO:TiO{sub 2} nano-photocatalysts (nphs) were optimized via response surface methodology (RSM). CPD was employed to improve the surface characteristics of the spacer fabrics for nphs loading. Surface morphology and color variation were studied utilizing scanning electron microscopy (SEM) and CIE-Lab system, respectively. The effect of CPD on the wetting ability of the spacer fabrics was examined using dynamic adsorption measurement (DAM). Also, X-ray fluorescence (XRF) was utilized to investigate the durability of the nphs on the spacer fabrics. All the experiments were implemented in a Box–Behnken design (BBD) with three independent variables (CPD treatment time, dye concentration and irradiation time) in order to optimize the decolorization of RO16. The anticipated values of the decolorization efficiency were found to be in excellent agreement with the experimental values (R{sup 2} = 0.9996, Adjusted R{sup 2} = 0.9992). The kinetic analysis demonstrated that the photocatalytic decolorization followed the Langmuir–Hinshelwood kinetic model. In conclusion, this heterogeneous photocatalytic process is capable of decolorizing and mineralizing azoic reactive dye in textile wastewater. Moreover, the results confirmed that RSM based on the BBD was a suitable method to optimize the operating conditions of RO16 degradation.

  5. Variations on agent-oriented programming

    Directory of Open Access Journals (Sweden)

    Dalia Baziukė

    2017-12-01

    Full Text Available Occurrence of the agent paradigm and its further applications have stimulated the emergence of new concepts and methodologies in computer science. Today terms like multi-agent system, agent-oriented methodology, and agent-oriented programming (AOP are widely used. The aim of this paper is to clarify the validity of usage of the terms AOP and AOP language. This is disclosed in two phases of an analysis process. Determining to which concepts, terms like agent, programming, object-oriented analysis and design, object-oriented programming, and agent-oriented analysis and design correspond is accomplished in the first phase. Analysis of several known agent system engineering methodologies in terms of key concepts used, final resulting artifacts, and their relationship with known programming paradigms and modern tools for agent system development is performed in the second phase. The research shows that in most cases in the final phase of agent system design and in the coding stage, the main artifact is an object, defined according to the rules of the object-oriented paradigm. Hence, we say that the computing society still does not have AOP owing to the lack of an AOP language. Thus, the term AOP is very often incorrectly assigned to agent system development frameworks that in most cases, transform agents into objects.DOI: 10.15181/csat.v5i1.1361

  6. Methodological Problems of Nanotechnoscience

    Science.gov (United States)

    Gorokhov, V. G.

    Recently, we have reported on the definitions of nanotechnology as a new type of NanoTechnoScience and on the nanotheory as a cluster of the different natural and engineering theories. Nanotechnology is not only a new type of scientific-engineering discipline, but it evolves also in a “nonclassical” way. Nanoontology or nano scientific world view has a function of the methodological orientation for the choice the theoretical means and methods toward a solution to the scientific and engineering problems. This allows to change from one explanation and scientific world view to another without any problems. Thus, nanotechnology is both a field of scientific knowledge and a sphere of engineering activity, in other words, NanoTechnoScience is similar to Systems Engineering as the analysis and design of large-scale, complex, man/machine systems but micro- and nanosystems. Nano systems engineering as well as Macro systems engineering includes not only systems design but also complex research. Design orientation has influence on the change of the priorities in the complex research and of the relation to the knowledge, not only to “the knowledge about something”, but also to the knowledge as the means of activity: from the beginning control and restructuring of matter at the nano-scale is a necessary element of nanoscience.

  7. Beginning C# Object-Oriented Programming

    CERN Document Server

    Clark, Dan

    2011-01-01

    Beginning C# Object-Oriented Programming brings you into the modern world of development as you master the fundamentals of programming with C# and learn to develop efficient, reusable, elegant code through the object-oriented programming (OOP) methodology. Take your skills out of the 20th century and into this one with Dan Clark's accessible, quick-paced guide to C# and object-oriented programming, completely updated for .NET 4.0 and C# 4.0. As you develop techniques and best practices for coding in C#, one of the world's most popular contemporary languages, you'll experience modeling a "real

  8. Testing methodologies

    Energy Technology Data Exchange (ETDEWEB)

    Bender, M.A.

    1990-01-01

    Several methodologies are available for screening human populations for exposure to ionizing radiation. Of these, aberration frequency determined in peripheral blood lymphocytes is the best developed. Individual exposures to large doses can easily be quantitated, and population exposures to occupational levels can be detected. However, determination of exposures to the very low doses anticipated from a low-level radioactive waste disposal site is more problematical. Aberrations occur spontaneously, without known cause. Exposure to radiation induces no new or novel types, but only increases their frequency. The limitations of chromosomal aberration dosimetry for detecting low level radiation exposures lie mainly in the statistical signal to noise'' problem, the distribution of aberrations among cells and among individuals, and the possible induction of aberrations by other environmental occupational or medical exposures. However, certain features of the human peripheral lymphocyte-chromosomal aberration system make it useful in screening for certain types of exposures. Future technical developments may make chromosomal aberration dosimetry more useful for low-level radiation exposures. Other methods, measuring gene mutations or even minute changes on the DNA level, while presently less will developed techniques, may eventually become even more practical and sensitive assays for human radiation exposure. 15 refs.

  9. Testing methodologies

    International Nuclear Information System (INIS)

    Bender, M.A.

    1990-01-01

    Several methodologies are available for screening human populations for exposure to ionizing radiation. Of these, aberration frequency determined in peripheral blood lymphocytes is the best developed. Individual exposures to large doses can easily be quantitated, and population exposures to occupational levels can be detected. However, determination of exposures to the very low doses anticipated from a low-level radioactive waste disposal site is more problematical. Aberrations occur spontaneously, without known cause. Exposure to radiation induces no new or novel types, but only increases their frequency. The limitations of chromosomal aberration dosimetry for detecting low level radiation exposures lie mainly in the statistical ''signal to noise'' problem, the distribution of aberrations among cells and among individuals, and the possible induction of aberrations by other environmental occupational or medical exposures. However, certain features of the human peripheral lymphocyte-chromosomal aberration system make it useful in screening for certain types of exposures. Future technical developments may make chromosomal aberration dosimetry more useful for low-level radiation exposures. Other methods, measuring gene mutations or even minute changes on the DNA level, while presently less will developed techniques, may eventually become even more practical and sensitive assays for human radiation exposure. 15 refs

  10. Development of symptoms-oriented operating procedures

    International Nuclear Information System (INIS)

    Colquhoun, R.

    1984-01-01

    Until recently, the formal treatment of control room procedures for upset conditions in nuclear power plants has been event-oriented. This orientation was not so much a reflection of power plant operating practice as it was a reflection of design-oriented thinking - design-basis events, therefore event-oriented procedures. Event orientation is not common in other professions. In the medical profession, for example, the stabilization of vital functions through a symptoms-oriented approach has priority over diagnosis and prognosis. The American nuclear power industry has initiated programs for the development and application of a symptoms-oriented approach for handling upset conditions. Canadian programs have independently paralleled the US programs. This article describes the rationale and current applications of the Canadian programs and identifies the relevance of a generic symptoms-based emergency procedure to current operating practices

  11. Entrepreneurial orientation, market orientation, and competitive environment

    DEFF Research Database (Denmark)

    Sørensen, Hans Eibe; Cadogan, John W.

    This study sheds light on the role that the competitive environment plays in determining how elements of market orientation and elements of entrepreneurial orientation interact to influence business success. We develop a model in which we postulate that market orientation, entrepreneurial...... orientation, and competitive environment shape business performance via a three-way interaction. We test the model using primary data from the CEOs of 270 CEO of manufacturing firms, together with secondary data on these firms' profit performance. An assessment of the results indicates that customer...... orientation moderates the positive relationships between the competitiveness element of entrepreneurial orientation and market share and return on assets (ROA): the positive relationships between competitiveness and market share and competitiveness and ROA become stronger the greater the firms' customer...

  12. Problem-oriented project studies

    DEFF Research Database (Denmark)

    Nielsen, Jørgen Lerche; Danielsen, Oluf

    2010-01-01

    and marking papers / essays is complemented and in some way overruled by a new role as supervisor and facilitator for the group of students working with a research problem, they themselves have picked. However different dimensions of this new teacher role can be seen – from expert in an academic field (result......-oriented focusing on how the final product demonstrates the students’ ‘correct’ way to handle the academic aspects of the subject in mind) to a role more focusing on processes, methodological dimensions and stressing the importance of a reflexive approach. Some teachers may even tend to take on a role...

  13. Safety analysis methodology for OPR 1000

    International Nuclear Information System (INIS)

    Hwang-Yong, Jun

    2005-01-01

    Full text: Korea Electric Power Research Institute (KEPRI) has been developing inhouse safety analysis methodology based on the delicate codes available to KEPRI to overcome the problems arising from currently used vendor oriented methodologies. For the Loss of Coolant Accident (LOCA) analysis, the KREM (KEPRI Realistic Evaluation Methodology) has been developed based on the RELAP-5 code. The methodology was approved for the Westinghouse 3-loop plants by the Korean regulatory organization and the project to extent the methodology to the Optimized Power Reactor 1000 (OPR1000) has been ongoing since 2001. Also, for the Non-LOCA analysis, the KNAP (Korea Non-LOCA Analysis Package) has been developed using the UNICORN-TM code system. To demonstrate the feasibility of these codes systems and methodologies, some typical cases of the design basis accidents mentioned in the final safety analysis report (FSAR) were analyzed. (author)

  14. practice-oriented research in service of designing interventions

    African Journals Online (AJOL)

    but rather practice oriented, and illustrates the need for n-type research. We present ... Problem owners are not involved in main-line qualitative or quantitative research. ... not only have knowledge of the research methodology, but should also.

  15. Comparative study on software development methodologies

    OpenAIRE

    Mihai Liviu DESPA

    2014-01-01

    This paper focuses on the current state of knowledge in the field of software development methodologies. It aims to set the stage for the formalization of a software development methodology dedicated to innovation orientated IT projects. The paper starts by depicting specific characteristics in software development project management. Managing software development projects involves techniques and skills that are proprietary to the IT industry. Also the software development project manager han...

  16. Comparative study on software development methodologies

    Directory of Open Access Journals (Sweden)

    Mihai Liviu DESPA

    2014-12-01

    Full Text Available This paper focuses on the current state of knowledge in the field of software development methodologies. It aims to set the stage for the formalization of a software development methodology dedicated to innovation orientated IT projects. The paper starts by depicting specific characteristics in software development project management. Managing software development projects involves techniques and skills that are proprietary to the IT industry. Also the software development project manager handles challenges and risks that are predominantly encountered in business and research areas that involve state of the art technology. Conventional software development stages are defined and briefly described. Development stages are the building blocks of any software development methodology so it is important to properly research this aspect. Current software development methodologies are presented. Development stages are defined for every showcased methodology. For each methodology a graphic representation is illustrated in order to better individualize its structure. Software development methodologies are compared by highlighting strengths and weaknesses from the stakeholder's point of view. Conclusions are formulated and a research direction aimed at formalizing a software development methodology dedicated to innovation orientated IT projects is enunciated.

  17. MRI of oriental cholangiohepatitis

    Energy Technology Data Exchange (ETDEWEB)

    Wani, N.A., E-mail: ahmad77chinar@gmail.co [Department of Radiodiagnosis and Imaging, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Srinagar (India); Robbani, I.; Kosar, T. [Department of Radiodiagnosis and Imaging, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Srinagar (India)

    2011-02-15

    Oriental cholangiohepatitis (OCH) also called recurrent pyogenic cholangitis is characterized by intrahepatic duct calculi, strictures, and recurrent infections. In turn cholangitis can result in multiple hepatic abscesses, further biliary strictures, and in severe cases, progressive hepatic parenchymal destruction, cirrhosis, and portal hypertension. Magnetic resonance cholangiopancreatography (MRCP) and conventional T1-weighted (T1 W) and T2-weighted (T2 W) magnetic resonance imaging (MRI) findings have been described in patients with OCH. MRCP findings include duct dilation, strictures, and calculi. MRCP can help to localize the diseased ducts and determine the severity of involvement. T1 and T2 W sequences reveal the parenchymal changes of atrophy, abscess formation, and portal hypertension in addition to calculi. Post-treatment changes are also well depicted using MRI. Comprehensive, non-invasive assessment is achieved by using conventional MRI and MRCP in OCH providing a roadmap for endoscopic or surgical management.

  18. Theories of Sexual Orientation.

    Science.gov (United States)

    Storms, Michael D.

    1980-01-01

    Results indicated homosexuals, heterosexuals, and bisexuals did not differ within each sex on measures of masculinity and femininity. Strong support was obtained for the hypothesis that sexual orientation relates primarily to erotic fantasy orientation. (Author/DB)

  19. Life cycle assessment in wastewater treatment: : Influence of site-oriented normalization factors, life cycle impact assessment methods, and weighting methods

    NARCIS (Netherlands)

    Bai, Shunwen; Wang, Xiuheng; Zhang, X.; Zhao, Xinyue; Ren, N

    2017-01-01

    This present study aims to analyze the differences in results of different site-directional life cycle assessment
    (LCA) methods applied in the field of wastewater treatment. Site-generic methods were employed and
    compared with China-specific methods on a full-scale wastewater treatment case.

  20. Valuing Orientation Efficacy: Rethinking Undergraduate Business Student's First Impressions

    Science.gov (United States)

    McPhail, Ruth; French, Ben; Wilson, Keithia

    2015-01-01

    Purpose: The purpose of this study was to improve the orientation experience of commencing first-year undergraduate business students to better prepare them for the reality of their academic studies through the development and implementation of a Commencing Student-Needs-Centred Orientation Framework. Design/methodology/approach: The methodology…

  1. Work orientations in the job demands-resources model

    NARCIS (Netherlands)

    Demerouti, E.; Bakker, A.B.; Fried, Y.

    2012-01-01

    Purpose – This study aims to examine the role of instrumental vs intrinsic work orientations in the job demands-resources (JD-R) model. Design/methodology – Using a sample of 123 employees, the authors investigated longitudinally whether an instrumental work orientation moderates the motivational

  2. Model of service-oriented catering supply chain performance evaluation

    OpenAIRE

    Gou, Juanqiong; Shen, Guguan; Chai, Rui

    2013-01-01

    Purpose: The aim of this paper is constructing a performance evaluation model for service-oriented catering supply chain. Design/methodology/approach: With the research on the current situation of catering industry, this paper summarized the characters of the catering supply chain, and then presents the service-oriented catering supply chain model based on the platform of logistics and information. At last, the fuzzy AHP method is used to evaluate the performance of service-oriented catering ...

  3. CONSEQUENCES OF EMPLOYEE’S CUSTOMER ORIENTATION IN PUBLIC SERVICES

    OpenAIRE

    Andrada IACOB

    2015-01-01

    The goal of this paper is to explore the consequences of employee’s customer orientation in public services organizations. We will start with a literature review of the theory of customer orientation measurement and the consequences of this orientation at organizational and individual level. Then, the research methodology and results are presented. Conclusions, research limitations and future directions are included at the end of the paper. We identified positive direct effects of the employe...

  4. High Performance Object-Oriented Scientific Programming in Fortran 90

    Science.gov (United States)

    Norton, Charles D.; Decyk, Viktor K.; Szymanski, Boleslaw K.

    1997-01-01

    We illustrate how Fortran 90 supports object-oriented concepts by example of plasma particle computations on the IBM SP. Our experience shows that Fortran 90 and object-oriented methodology give high performance while providing a bridge from Fortran 77 legacy codes to modern programming principles. All of our object-oriented Fortran 90 codes execute more quickly thatn the equeivalent C++ versions, yet the abstraction modelling capabilities used for scentific programming are comparably powereful.

  5. Mysticism and/in the Old Testament: Methodological orientation and ...

    African Journals Online (AJOL)

    2015-11-17

    Nov 17, 2015 ... suppositions (most directly the concepts rendered by Plato and Aristotle) and rhetorical ... possibilities here would lie the ideals of the disappearance-of-being, when ... There is thus no problem with historically identifying the ... ways typical of the era in which we live under Western(ised) cultural hegemony.

  6. Relational and Object-Oriented Methodology in Data Bases Systems

    Directory of Open Access Journals (Sweden)

    Marian Pompiliu CRISTESCU

    2006-01-01

    Full Text Available Database programming languages integrate concepts of databases and programming languages to provide both implementation tools for data-intensive applications and high-level user interfaces to databases. Frequently, database programs contain a large amount of application knowledge which is hidden in the procedural code and thus difficult to maintain with changing data and user views. This paper presents a first attempt to improve the situation by supporting the integrated definition and management of data and rules based on a setoriented and predicative approach. The use of database technology for integrated fact and rule base management is shown to have some important advantages in terms of fact and rule integrity, question-answering, and explanation of results.

  7. A refinement methodology for object-oriented programs

    OpenAIRE

    Tafat , Asma; Boulmé , Sylvain; Marché , Claude

    2010-01-01

    International audience; Refinement is a well-known approach for developing correct-byconstruction software. It has been very successful for producing high quality code e.g., as implemented in the B tool. Yet, such refinement techniques are restricted in the sense that they forbid aliasing (and more generally sharing of data-structures), which often happens in usual programming languages. We propose a sound approach for refinement in presence of aliases. Suitable abstractions of programs are d...

  8. Guión de video conferencia para orientaciones metodológicas a los facilitadores de biología celular y molecular A Program based on video- conferences for methodological orientations to the professors of cell and molecular biology

    Directory of Open Access Journals (Sweden)

    Maritza Linares Guerra

    2007-06-01

    Knowledge, Skill, Classes and Evaluation giving also the general indications for the study of the Subject. It was emphasized the methodological structure and the role of the Professor in the different ways of organization of the teaching process within the syllabus .A study of the syllabus (8 was performed demonstrating the importance of the teaching systematization as well as the way of organization of the contents beginning from the lower level up to the higher. It is concluded that video-conferences for the methodological orientations represents an useful tool for the Professors of the Biomedical Science and specially for those are not near and lack of the possibilities of the frequent personal communication with the methodological assessors in the mother facility.

  9. A Research Agenda for Service-Oriented Architecture (SOA): Maintenance and Evolution of Service-Oriented Systems

    Science.gov (United States)

    2010-03-01

    service consumers, and infrastructure. Techniques from any iterative and incremental software development methodology followed by the organiza- tion... Service -Oriented Architecture Environment (CMU/SEI-2008-TN-008). Software Engineering Institute, Carnegie Mellon University, 2008. http://www.sei.cmu.edu...Integrating Legacy Software into a Service Oriented Architecture.” Proceedings of the 10th European Conference on Software Maintenance (CSMR 2006). Bari

  10. GO methodology. Volume 1. Overview manual

    International Nuclear Information System (INIS)

    1983-06-01

    The GO methodology is a success-oriented probabilistic system performance analysis technique. The methodology can be used to quantify system reliability and availability, identify and rank critical components and the contributors to system failure, construct event trees, and perform statistical uncertainty analysis. Additional capabilities of the method currently under development will enhance its use in evaluating the effects of external events and common cause failures on system performance. This Overview Manual provides a description of the GO Methodology, how it can be used, and benefits of using it in the analysis of complex systems

  11. Application of Agent Methodology in Healthcare Information Systems

    Directory of Open Access Journals (Sweden)

    Reem Abdalla

    2017-02-01

    Full Text Available This paper presents a case study to describe the features and the phases of the two agent methodologies. The Gaia methodology for agent oriented analysis and design, Tropos is a detailed agent oriented software engineering methodology to explore each methodology's ability to present solutions for small problems. Also we provide an attempt to discover whether the methodology is in fact understandable and usable. In addition we were collecting and taking notes of the advantages and weaknesses of these methodologies during the study analysis for each methodology and the relationships among their models. The Guardian Angle: Patient-Centered Health Information System (GA: PCHIS is the personal system to help track, manage, and interpret the subject's health history, and give advice to both patient and provider is used as the case study throughout the paper.

  12. Measuring the Recovery Orientation of ACT

    Science.gov (United States)

    Salyers, Michelle P.; Stull, Laura G.; Rollins, Angela L.; McGrew, John H.; Hicks, Lia J.; Thomas, Dave; Strieter, Doug

    2014-01-01

    Background Approaches to measuring recovery orientation are needed, particularly for programs that may struggle with implementing recovery-oriented treatment. Objective A mixed methods comparative study was conducted to explore effective approaches to measuring recovery orientation of Assertive Community Treatment (ACT) teams. Design Two ACT teams exhibiting high and low recovery orientation were compared using surveys, treatment plan ratings, diaries of treatment visits, and team-leader-reported treatment control mechanisms. Results The recovery-oriented team differed on one survey measure (higher expectations for consumer recovery), treatment planning (greater consumer involvement and goal-directed content), and use of control mechanisms (less use of representative payee, agency-held lease, daily medication delivery, and family involvement). Staff and consumer diaries showed the most consistent differences (e.g., conveying hope and choice) and were the least susceptible to observer bias, but had the lowest response rates. Conclusions Several practices differentiate recovery orientation on ACT teams, and a mixed-methods assessment approach is feasible. PMID:23690285

  13. Understanding political market orientation

    DEFF Research Database (Denmark)

    Ormrod, Robert P.; Henneberg, Stephan C.

    influences of such behavior. The study includes structural equation modeling to investigate several propositions. While the results show that political parties need to focus on several different aspects of market-oriented behavior, especially using an internal and external orientation as cultural antecedents......This article develops a conceptual framework and measurement model of political market orientation that consists of attitudinal and behavioural constructs. The article reports on perceived relationships among different behavioral aspects of political market orientation and the attitudinal......, a more surprising result is the inconclusive effect of a voter orientation on market-oriented behaviours. The article discusses the findings in the context of the existing literature in political marketing and commercial market orientation....

  14. Measuring Entrepreneurial Orientation in the Social Context

    Directory of Open Access Journals (Sweden)

    Rafał Kusa

    2016-09-01

    Full Text Available Objective: The objective of this paper is to identify differences between measurement of organisational entrepreneurship in for-profit and non-profit context and to propose the measures aligned to non-profit organisations. The main research question is whether the scales designed to measure entrepreneurial orientation can be used in non-profit organisations and under which conditions. Research Design & Methods: Research methodology is based on review of research tools and measurement scales related to organisational entrepreneurship and comparison of for-profit and non-profit organisations, as well as their characteristics in the context of entrepreneurial orientation. Findings: Entrepreneurial orientation can be measured in non-profit organisations using existing scales that have been designed for business organisations, however they have to be modified, mostly in the dimension of competitive aggressiveness and autonomy. Additionally, the scale should be enriched with items related to cooperation with other organisations. Implications & Recommendations: It is necessary to develop methods and tools that enable the measurement of entrepreneurial orientation in non-profit organisation as well as comparative research on entrepreneurial orientation in for-profit and non-profit organisations. Contribution & Value Added: The originality of this work lies in studying some aspects of entrepreneurial orientation, that apply to the social context. Some suggestions were formulated relating to the utilisation of entrepreneurial orientation scales (originally designed for business enterprises in non-profit organisations.

  15. A Case Report of Intra-articular Bee Venom Pharmacopuncture combining with oriental medical treatment for Acute Traumatic Partial Tear of Meniscus.

    Directory of Open Access Journals (Sweden)

    Lee Jae-Hoon

    2010-12-01

    Full Text Available This case was report of intra-articular bee venom pharmacopuncture injection on the patient with Acute Traumatic Partial tear of meniscus. We used intra-articular bee venom pharmacopuncture injection to Acute Traumatic Partial tear of meniscus diagnosed by symptoms and MR imaging. Be under treatment if necessary we prescribed herbal medication and physiotherapy. The state of patient was measured by Visual Analog Scale(VAS and Walking time and Western Ontario and McMaster Universities(WOMAC Index score. After several times of treatments, noticeable reduction of pain was measured and increased time of walking on floor and decreased WOMAC score. This results suggest that intra-articular bee venom pharmacopuncture injection are effective to treatments of Acute Traumatic Partial tear of meniscus.

  16. Clinical trial methodology

    National Research Council Canada - National Science Library

    Peace, Karl E; Chen, Ding-Geng

    2011-01-01

    ... in the pharmaceutical industry, Clinical trial methodology emphasizes the importance of statistical thinking in clinical research and presents the methodology as a key component of clinical research...

  17. An object-oriented approach to energy-economic modeling

    Energy Technology Data Exchange (ETDEWEB)

    Wise, M.A.; Fox, J.A.; Sands, R.D.

    1993-12-01

    In this paper, the authors discuss the experiences in creating an object-oriented economic model of the U.S. energy and agriculture markets. After a discussion of some central concepts, they provide an overview of the model, focusing on the methodology of designing an object-oriented class hierarchy specification based on standard microeconomic production functions. The evolution of the model from the class definition stage to programming it in C++, a standard object-oriented programming language, will be detailed. The authors then discuss the main differences between writing the object-oriented program versus a procedure-oriented program of the same model. Finally, they conclude with a discussion of the advantages and limitations of the object-oriented approach based on the experience in building energy-economic models with procedure-oriented approaches and languages.

  18. Chronic Obstructive Pulmonary Disease: official diagnosis and treatment guidelines of the Czech Pneumological and Phthisiological Society; a novel phenotypic approach to COPD with patient-oriented care.

    Science.gov (United States)

    Koblizek, Vladimir; Chlumsky, Jan; Zindr, Vladimir; Neumannova, Katerina; Zatloukal, Jakub; Zak, Jaroslav; Sedlak, Vratislav; Kocianova, Jana; Zatloukal, Jaromir; Hejduk, Karel; Pracharova, Sarka

    2013-06-01

    COPD is a global concern. Currently, several sets of guidelines, statements and strategies to managing COPD exist around the world. The Czech Pneumological and Phthisiological Society (CPPS) has commissioned an Expert group to draft recommended guidelines for the management of stable COPD. Subsequent revisions were further discussed at the National Consensus Conference (NCC). Reviewers' comments contributed to the establishment of the document's final version. The hallmark of the novel approach to COPD is the integrated evaluation of the patient's lung functions, symptoms, exacerbations and identifications of clinical phenotype(s). The CPPS defines 6 clinically relevant phenotypes: frequent exacerbator, COPD-asthma overlap, COPD-bronchiectasis overlap, emphysematic phenotype, bronchitic phenotype and pulmonary cachexia phenotype. Treatment recommendations can be divided into four steps. 1(st) step = Risk exposure elimination: reduction of smoking and environmental tobacco smoke (ETS), decrease of home and occupational exposure risks. 2(nd) step = Standard treatment: inhaled bronchodilators, regular physical activity, pulmonary rehabilitation, education, inhalation training, comorbidity treatment, vaccination. 3(rd) step = Phenotype-specific therapy: PDE4i, ICS+LABA, LVRS, BVR, AAT augmentation, physiotherapy, mucolytic, ABT. 4(th) step = Care for respiratory insufficiency and terminal COPD: LTOT, lung transplantation, high intensity-NIV and palliative care. Optimal treatment of COPD patients requires an individualised, multidisciplinary approach to the patient's symptoms, clinical phenotypes, needs and wishes. The new Czech COPD guideline reflects and covers these requirements.

  19. Failure mode and effect analysis oriented to risk-reduction interventions in intraoperative electron radiation therapy: the specific impact of patient transportation, automation, and treatment planning availability.

    Science.gov (United States)

    López-Tarjuelo, Juan; Bouché-Babiloni, Ana; Santos-Serra, Agustín; Morillo-Macías, Virginia; Calvo, Felipe A; Kubyshin, Yuri; Ferrer-Albiach, Carlos

    2014-11-01

    Industrial companies use failure mode and effect analysis (FMEA) to improve quality. Our objective was to describe an FMEA and subsequent interventions for an automated intraoperative electron radiotherapy (IOERT) procedure with computed tomography simulation, pre-planning, and a fixed conventional linear accelerator. A process map, an FMEA, and a fault tree analysis are reported. The equipment considered was the radiance treatment planning system (TPS), the Elekta Precise linac, and TN-502RDM-H metal-oxide-semiconductor-field-effect transistor in vivo dosimeters. Computerized order-entry and treatment-automation were also analyzed. Fifty-seven potential modes and effects were identified and classified into 'treatment cancellation' and 'delivering an unintended dose'. They were graded from 'inconvenience' or 'suboptimal treatment' to 'total cancellation' or 'potentially wrong' or 'very wrong administered dose', although these latter effects were never experienced. Risk priority numbers (RPNs) ranged from 3 to 324 and totaled 4804. After interventions such as double checking, interlocking, automation, and structural changes the final total RPN was reduced to 1320. FMEA is crucial for prioritizing risk-reduction interventions. In a semi-surgical procedure like IOERT double checking has the potential to reduce risk and improve quality. Interlocks and automation should also be implemented to increase the safety of the procedure. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  20. Identification of barriers to the prevention and treatment of heat-related illness in Latino farmworkers using activity-oriented, participatory rural appraisal focus group methods.

    Science.gov (United States)

    Lam, Michelle; Krenz, Jennifer; Palmández, Pablo; Negrete, Maria; Perla, Martha; Murphy-Robinson, Helen; Spector, June T

    2013-10-24

    Heat-related illness (HRI) is an important cause of non-fatal illness and death in farmworkers. We sought to identify potential barriers to HRI prevention and treatment in Latino farmworkers. We conducted three semi-structured focus group discussions with 35 Latino farmworkers in the Central Washington, USA area using participatory rural appraisal techniques. Interviews were audio taped and transcribed in Spanish. Three researchers reviewed and coded transcripts and field notes, and investigator triangulation was used to identify relevant themes and quotes. Although the majority of participants in our study reported never receiving formal HRI training, most participants were aware that extreme heat can cause illness and were able to accurately describe HRI symptoms, risk factors, and certain prevention strategies. Four main observations regarding farmworkers' HRI-relevant beliefs and attitudes were identified: 1) farmworkers subscribe to varying degrees to the belief that cooling treatments should be avoided after heat exposure, with some believing that such treatments should be avoided after heat exposure, and others encouraging the use of such treatments; 2) the desire to lose weight may be reflected in behaviors that promote increased sweating; 3) highly caffeinated energy drinks are preferred to increase work efficiency and maintain alertness; and 4) the location of drinking water at work (e.g. next to restrooms) and whether water is clean, but not necessarily chemically-treated, are important considerations in deciding whether to drink the water provided at worksites. We identified potential barriers to HRI prevention and treatment related to hydration, certain HRI treatments, clothing use, and the desire to lose weight among Latino farmworkers. Strategies to address potential barriers to HRI prevention and treatment in this population may include engineering, administrative, and health education and health promotion strategies at individual, workplace

  1. Project Oriented Immersion Learning: Method and Results

    DEFF Research Database (Denmark)

    Icaza, José I.; Heredia, Yolanda; Borch, Ole M.

    2005-01-01

    A pedagogical approach called “project oriented immersion learning” is presented and tested on a graduate online course. The approach combines the Project Oriented Learning method with immersion learning in a virtual enterprise. Students assumed the role of authors hired by a fictitious publishing...... house that develops digital products including e-books, tutorials, web sites and so on. The students defined the problem that their product was to solve; choose the type of product and the content; and built the product following a strict project methodology. A wiki server was used as a platform to hold...

  2. Failure mode and effect analysis oriented to risk-reduction interventions in intraoperative electron radiation therapy: The specific impact of patient transportation, automation, and treatment planning availability

    International Nuclear Information System (INIS)

    López-Tarjuelo, Juan; Bouché-Babiloni, Ana; Santos-Serra, Agustín; Morillo-Macías, Virginia; Calvo, Felipe A.; Kubyshin, Yuri

    2014-01-01

    Background and purpose: Industrial companies use failure mode and effect analysis (FMEA) to improve quality. Our objective was to describe an FMEA and subsequent interventions for an automated intraoperative electron radiotherapy (IOERT) procedure with computed tomography simulation, pre-planning, and a fixed conventional linear accelerator. Material and methods: A process map, an FMEA, and a fault tree analysis are reported. The equipment considered was the radiance treatment planning system (TPS), the Elekta Precise linac, and TN-502RDM-H metal–oxide-semiconductor-field-effect transistor in vivo dosimeters. Computerized order-entry and treatment-automation were also analyzed. Results: Fifty-seven potential modes and effects were identified and classified into ‘treatment cancellation’ and ‘delivering an unintended dose’. They were graded from ‘inconvenience’ or ‘suboptimal treatment’ to ‘total cancellation’ or ‘potentially wrong’ or ‘very wrong administered dose’, although these latter effects were never experienced. Risk priority numbers (RPNs) ranged from 3 to 324 and totaled 4804. After interventions such as double checking, interlocking, automation, and structural changes the final total RPN was reduced to 1320. Conclusions: FMEA is crucial for prioritizing risk-reduction interventions. In a semi-surgical procedure like IOERT double checking has the potential to reduce risk and improve quality. Interlocks and automation should also be implemented to increase the safety of the procedure

  3. Treatment of a Patient with Borderline Personality Disorder Based on Phase-Oriented Model of Eye Movement Desensitization and Reprocessing (EMDR: A Case Report

    Directory of Open Access Journals (Sweden)

    Nahid Momeni Safarabad

    2018-02-01

    Full Text Available Objective: This study aimed at reporting the effect of the 3-phase model of eye movement desensitization and reprocessing in the treatment of a patient with borderline personality disorder.Method: A 33-year-old female, who met the DSM-IV-TR criteria for borderline personality disorder, received a 20-session therapy based on the 3-phase model of eye movement desensitization and reprocessing. Borderline Personality Disorder Checklist (BPD-Checklist, Dissociative Experience Scale (DES-II, Beck Depression Inventory-II-second edition (BDI-II, and Anxiety Inventory (BAI were filled out by the patient at all treatment phases and at the 3- month follow- up.Results: According to the obtained results, the patient’s pretest scores in all research tools were 161, 44, 37, and 38 for BPD-Checklist, DES-II, BDI-II, and BAI, respectively. After treatment, these scores decreased significantly (69, 14, 6 and 10 respectively. So, the patient exhibited improvement in borderline personality disorder, dissociative, depression and anxiety symptoms, which were maintained after the 3-month follow-up.Conclusion: The results supported the positive effect of phasic model of eye movement desensitization and reprocessing on borderline personality disorder.

  4. Safeguarding the fuel cycle: Methodologies

    International Nuclear Information System (INIS)

    Gruemm, H.

    1984-01-01

    The effectiveness of IAEA safeguards is characterized by the extent to which they achieve their basic purpose - credible verification that no nuclear material is diverted from peaceful uses. This effectiveness depends inter alia but significantly on manpower in terms of the number and qualifications of inspectors. Staff increases will be required to improve effectiveness further, if this is requested by Member States, as well as to take into account new facilities expected to come under safeguards in the future. However, they are difficult to achieve due to financial constraints set by the IAEA budget. As a consequence, much has been done and is being undertaken to improve utilization of available manpower, including standardization of inspection procedures; improvement of management practices and training; rationalization of planning, reporting, and evaluation of inspection activities; and development of new equipment. This article focuses on certain aspects of the verification methodology presently used and asks: are any modifications of this methodology conceivable that would lead to economies of manpower, without loss of effectiveness. It has been stated in this context that present safeguards approaches are ''facility-oriented'' and that the adoption of a ''fuel cycle-oriented approach'' might bring about the desired savings. Many studies have been devoted to this very interesting suggestion. Up to this moment, no definite answer is available and further studies will be necessary to come to a conclusion. In what follows, the essentials of the problem are explained and some possible paths to a solution are discussed

  5. Dialectic Antidotes to Critics of the Technology Acceptance Model: Conceptual, Methodological, and Replication Treatments for Behavioural Modelling in Technology-Mediated Environments

    Directory of Open Access Journals (Sweden)

    Weng Marc Lim

    2018-01-01

    Full Text Available The technology acceptance model (TAM is a prominent and parsimonious conceptual lens that is often applied for behavioural modelling in technology-mediated environments. However, TAM has received a great deal of criticism in recent years. This article aims to address some of the most pertinent issues confronting TAM through a rejoinder that offers dialectic antidotes—in the form of conceptual, methodological, and replication treatments—to support the continued use of TAM to understand the peculiarities of user interactions with technology in technology-mediated environments. In doing so, this article offers a useful response to a common but often inadequately answered question about how TAM can continue to be relevant for behavioural modelling in contemporary technology-mediated environments.

  6. A study on methodological of software development for HEP

    International Nuclear Information System (INIS)

    Ding Yuzheng; Dai Guiliang

    1999-01-01

    The HEP related software system is a large one. It comprises mainly detector simulation software, DAQ software and offline system. The author discusses the advantages of OO object oriented methodologies applying to such software system, and the basic strategy for the usage of OO methodologies, languages and tools in the development of the HEP related software are given

  7. Incidence estimate and guideline-oriented treatment for post-stroke spasticity: an analysis based on German statutory health insurance data

    Directory of Open Access Journals (Sweden)

    Egen-Lappe V

    2013-03-01

    Full Text Available Veronika Egen-Lappe, Ingrid Köster, Ingrid SchubertPMV Research Group, Department of Child and Adolescence Psychiatry and Psychotherapy, University of Cologne, Cologne, GermanyBackground: Spasticity after stroke has been internationally recognized as an important health problem causing impairment of mobility, deformity, and pain. The aim of this study was to assess the frequency of first-ever and recurrent stroke and of subsequent spastic and flaccid paresis. Factors influencing the development of spasticity were analyzed. A further major aim was to provide a "real-life" assessment of the treatment of spasticity in Germany and to discuss this in view of the treatment recommended by German and international clinical guidelines.Methods: The database used in this study comprised a cohort of 242,090 insurants from a large statutory health insurance fund in the federal state of Hesse, Germany. A first hospital discharge diagnosis in 2009 with any of the International Classification of Diseases, Tenth Revision (ICD-10 codes I60–I64 was used to identify patients with acute stroke (hemorrhage and ischemic. These patients were followed up six months after stroke to monitor whether they developed spastic or flaccid paresis (hospital or ambulatory care diagnoses ICD-10 code G81–G83 [excluding G82.6/G83.4/G83.8]. For patients with spastic paresis after stroke the spasticity treatment was analyzed for a six-month period (physiotherapy, oral muscle relaxants, intrathecal baclofen, and botulinum toxin.Results: Standardized to the population of Germany, 3.7 per 1000 persons suffered a stroke in 2009 (raw 5.2/1000. Of all surviving patients, 10.2% developed spasticity within 6 months. Cox regression revealed no significant influence of patient age, gender, morbidity (diabetes, hypertensive diseases, ischemic heart diseases or type of stroke on development of spasticity. 97% of surviving patients with spasticity received physiotherapy (inpatient care 89

  8. Entrepreneurial Orientation and Internationalisation

    DEFF Research Database (Denmark)

    Decker, Arnim; Rollnik-Sadowska, Ewa; Servais, Per

    Entrepreneurial orientation is a multidimensional construct that determines the strategic posture of a firm. In this study we investigate a sample of six manufacturing firms which are located both in a remote area and in a transition economy. Through interpreting the construct of entrepreneurial...... orientation as an attitude held by principals we investigate how entrepreneurial orientation affected the behaviour of these firms, specifically in terms of their internationalisation. Despite the fact that all firms have identical roots we find that entrepreneurial orientation held by their principals affect...

  9. CONSEQUENCES OF EMPLOYEE’S CUSTOMER ORIENTATION IN PUBLIC SERVICES

    Directory of Open Access Journals (Sweden)

    Andrada IACOB

    2015-06-01

    Full Text Available The goal of this paper is to explore the consequences of employee’s customer orientation in public services organizations. We will start with a literature review of the theory of customer orientation measurement and the consequences of this orientation at organizational and individual level. Then, the research methodology and results are presented. Conclusions, research limitations and future directions are included at the end of the paper. We identified positive direct effects of the employee customer orientation on organizational commitment and organizational identification, but no significant direct relationship with job satisfaction.

  10. Formalizing the ISDF Software Development Methodology

    Directory of Open Access Journals (Sweden)

    Mihai Liviu DESPA

    2015-01-01

    Full Text Available The paper is aimed at depicting the ISDF software development methodology by emphasizing quality management and software development lifecycle. The ISDF methodology was built especially for innovative software development projects. The ISDF methodology was developed empirically by trial and error in the process of implementing multiple innovative projects. The research process began by analysing key concepts like innovation and software development and by settling the important dilemma of what makes a web application innovative. Innovation in software development is presented from the end-user, project owner and project manager’s point of view. The main components of a software development methodology are identified. Thus a software development methodology should account for people, roles, skills, teams, tools, techniques, processes, activities, standards, quality measuring tools, and team values. Current software development models are presented and briefly analysed. The need for a dedicated innovation oriented software development methodology is emphasized by highlighting shortcomings of current software development methodologies when tackling innovation. The ISDF methodology is presented in the context of developing an actual application. The ALHPA application is used as a case study for emphasizing the characteristics of the ISDF methodology. The development life cycle of the ISDF methodology includes research, planning, prototyping, design, development, testing, setup and maintenance. Artefacts generated by the ISDF methodology are presented. Quality is managed in the ISDF methodology by assessing compliance, usability, reliability, repeatability, availability and security. In order to properly asses each quality component a dedicated indicator is built. A template for interpreting each indicator is provided. Conclusions are formulated and new related research topics are submitted for debate.

  11. Wildlife value orientations

    DEFF Research Database (Denmark)

    Gamborg, Christian; Jensen, Frank Søndergaard

    2016-01-01

    This article examined value orientations toward wildlife among the adult general Danish public in relation to age, sex, past and present residence, education, and income, using a U.S. survey instrument on Wildlife Value Orientations (WVO). The study used an Internet-based questionnaire sent...

  12. Edward Said and "Orientalism"

    Science.gov (United States)

    Chronicle of Higher Education, 2007

    2007-01-01

    In the nearly 30 years since Edward Said published the hugely influential Orientalism, his indictment of racism and imperialism in Western scholarship on the Orient has had its share of plaudits and condemnations. Now Robert Irwin, the Middle East editor of The Times Literary Supplement, has reignited the controversy with his broadside against the…

  13. Orientalism/Occidentalism

    NARCIS (Netherlands)

    Minca, C.; Ong, C.E.

    2017-01-01

    Orientalism and Occidentalism are interrelated concepts. Orientalism is defined in three keys ways: (i) as a study of “the Orient”; (ii) as a cultural and aesthetic concern with “the Orient”; and (iii) as a critical approach to understanding the construction of “the Orient” by European and American

  14. Aspect-Oriented Programming

    NARCIS (Netherlands)

    Bergmans, Lodewijk; Videira Lopes, Cristina; Moreira, Ana; Demeyer, Serge

    1999-01-01

    Aspect-oriented programming is a promising idea that can improve the quality of software by reduce the problem of code tangling and improving the separation of concerns. At ECOOP'97, the first AOP workshop brought together a number of researchers interested in aspect-orientation. At ECOOP'98, during

  15. Object oriented programming

    International Nuclear Information System (INIS)

    Kunz, P.F.

    1990-01-01

    This paper is an introduction to object oriented programming techniques. It tries to explain the concepts by using analogies with traditional programming. The object oriented approach not inherently difficult, but most programmers find a relatively high threshold in learning it. Thus, this paper will attempt to convey the concepts with examples rather than explain the formal theory

  16. What is an acceptable outcome of treatment before it begins? Methodological considerations and implications for patients with chronic low back pain

    DEFF Research Database (Denmark)

    Lauridsen, Henrik; Manniche, Claus; Korsholm, Lars

    2009-01-01

    (LBP) patients' view of an acceptable change (MCID(pre)) before treatment begins. One-hundred and forty-seven patients with chronic LBP were recruited from an out-patient hospital back pain unit and followed over an 8-week period. Original and modified versions of the Oswestry disability index (ODI...

  17. A Needs Assessment for Health Care Professionals in the Detection, Intervention and Interdisciplinary Treatment of Bulimia Nervosa Using Focus Group Methodology

    Science.gov (United States)

    Hague, Anne; Kovacich, Joann

    2007-01-01

    The incidence of bulimia nervosa has increased significantly in the second half of the twentieth century and its occurrence is more than twice that of anorexia nervosa. Due to its complex nature, successful treatment requires an interdisciplinary approach with nutritional, psychological, medical, pharmacological and dental therapies. Despite…

  18. Anxiety Sensitivity Physical and Cognitive Concerns in Relation to Smoking-oriented Cognition: An Examination Among Treatment-seeking Adults Who Smoke.

    Science.gov (United States)

    Langdon, Kirsten J; Bakhshaie, Jafar; Lopez, Alicia; Tavakoli, Niloofar; Garey, Lorra; Raines, Amanda M; Kauffman, Brooke Y; Schmidt, Norman B; Zvolensky, Michael J

    Elevated levels of anxiety sensitivity (AS; fear of anxiety and internal sensations) is highly common among adults who smoke, and contributes to several maladaptive smoking beliefs and behaviors. AS is comprised of 3 empirically established factors, relating to fears of social concerns, fears of physical symptoms, and fears of cognitive dyscontrol. Relatively few studies have examined how these 3 subscales pertain to smoking processes. The aim of the present investigation was to examine, among treatment-seeking adults who smoke, the interactive effects of AS-physical and cognitive concerns in relation to: perceived barriers to smoking cessation; smoking-related negative reinforcement expectancies; and smoking-related avoidance and inflexibility. Participants included 470 adults who smoke (47.8% female; mean age 37.2, SD 13.5), who were recruited to participate in a smoking-cessation treatment study. At the baseline assessment, participants completed self-report measures, including the Anxiety Sensitivity Index-3, Barriers to Cessation Scale, Smoking Consequences Questionnaire, and Avoidance and Inflexibility Scale. Results indicated that after controlling for the effects of sex, cigarette dependence, alcohol problems, tobacco-related medical illness, current axis 1 disorder, and AS-social concerns, a significant interaction emerged, such that the association between AS-cognitive concerns and the studied smoking-based cognitions were stronger among lower levels of AS-physical concerns (but not higher physical concerns). The current findings suggest that it may be beneficial to provide specialized smoking-cessation interventions for certain subgroups of adults who smoke, such as those with different AS profiles, to promote healthier beliefs about quitting.

  19. Improving Access to Eye Care among Persons at High-Risk of Glaucoma in Philadelphia — Design and Methodology: The Philadelphia Glaucoma Detection and Treatment Project

    Science.gov (United States)

    Myers, Jonathan S.; Henderer, Jeffrey; Crews, John E.; Saaddine, Jinan B.; Molineaux, Jeanne; Johnson, Deiana; Sembhi, Harjeet; Stratford, Shayla; Suleiman, Ayman; Pizzi, Laura; Spaeth, George L.; Katz, L. Jay

    2016-01-01

    Purpose The Wills Eye Glaucoma Research Center initiated a 2-year demonstration project to develop and implement a community-based intervention to improve detection and management of glaucoma in Philadelphia. Methods The glaucoma detection examination consisted of: ocular, medical, and family history; visual acuity testing; corneal pachymetry; biomicroscopy of the anterior segment; intraocular pressure (IOP) measurement; gonioscopy; funduscopy; automated visual field testing; and fundus-color photography. Treatment included laser surgery and/or IOP-lowering medication. A cost analysis was conducted to understand resource requirements. Outcome measures included; prevalence of glaucoma-related pathology and other eye diseases among high-risk populations; the impact of educational workshops on level of knowledge about glaucoma (assessed by pre- and post-test evaluation); and patient satisfaction of the glaucoma detection examinations in the community (assessed by satisfaction survey). Treatment outcome measures were change in IOP at 4–6 weeks and 4–6 months following selective laser trabeculoplasty treatment, deepening of the anterior chamber angle following laser-peripheral iridotomy treatment, and rate of adherence to recommended follow-up examinations. Cost outcomes included total program costs, cost per case of glaucoma detected, and cost per case of ocular disease detected. Results This project enrolled 1649 participants (African Americans aged 50+ years, adults 60+ years and individuals with a family history of glaucoma). A total of 1074 individuals attended a glaucoma educational workshop and 1508 scheduled glaucoma detection examination appointments in the community setting. Conclusions The Philadelphia Glaucoma Detection and Treatment Project aimed to improve access and use of eye care and to provide a model for a targeted community-based glaucoma program. PMID:26950056

  20. Improving Access to Eye Care among Persons at High-Risk of Glaucoma in Philadelphia--Design and Methodology: The Philadelphia Glaucoma Detection and Treatment Project.

    Science.gov (United States)

    Hark, Lisa; Waisbourd, Michael; Myers, Jonathan S; Henderer, Jeffrey; Crews, John E; Saaddine, Jinan B; Molineaux, Jeanne; Johnson, Deiana; Sembhi, Harjeet; Stratford, Shayla; Suleiman, Ayman; Pizzi, Laura; Spaeth, George L; Katz, L Jay

    2016-01-01

    The Wills Eye Glaucoma Research Center initiated a 2-year demonstration project to develop and implement a community-based intervention to improve detection and management of glaucoma in Philadelphia. The glaucoma detection examination consisted of: ocular, medical, and family history; visual acuity testing; corneal pachymetry; biomicroscopy of the anterior segment; intraocular pressure (IOP) measurement; gonioscopy; funduscopy; automated visual field testing; and fundus-color photography. Treatment included laser surgery and/or IOP-lowering medication. A cost analysis was conducted to understand resource requirements. Outcome measures included; prevalence of glaucoma-related pathology and other eye diseases among high-risk populations; the impact of educational workshops on level of knowledge about glaucoma (assessed by pre- and post-test evaluation); and patient satisfaction of the glaucoma detection examinations in the community (assessed by satisfaction survey). Treatment outcome measures were change in IOP at 4-6 weeks and 4-6 months following selective laser trabeculoplasty treatment, deepening of the anterior chamber angle following laser-peripheral iridotomy treatment, and rate of adherence to recommended follow-up examinations. Cost outcomes included total program costs, cost per case of glaucoma detected, and cost per case of ocular disease detected. This project enrolled 1649 participants (African Americans aged 50+ years, adults 60+ years and individuals with a family history of glaucoma). A total of 1074 individuals attended a glaucoma educational workshop and 1508 scheduled glaucoma detection examination appointments in the community setting. The Philadelphia Glaucoma Detection and Treatment Project aimed to improve access and use of eye care and to provide a model for a targeted community-based glaucoma program.

  1. New linkage of P and T (Partitioning and Transmutation) treatment with methodology of geologic disposal. A possible breakthrough for nuclear technology in tomorrow

    International Nuclear Information System (INIS)

    Kitamoto, Asashi

    1999-01-01

    A possibility of a safe, reliable, transparent and economical high-level radioactive waste disposal method is proposed by combining partitioning of waste materials and transmutation of long-life nuclides with geologic disposal. The paper first discusses the environment surrounding nuclear energy and the conditions for social acceptance of nuclear energy. Then, the paper talks about the soundness of geologic disposal as most extensively studied method of radioactive waste, including environment, safety assessment model, unpredictable uncertainty, and macro image and its problems. Thirdly, the paper describes partitioning and transmutation, the latter being reduction of the lives of long-life nuclides by nuclear fission and conversion and the former being methodology to achieve it by rational means. Radionuclides are separated into six groups by three selection rules of transmutation and two selection rules of geologic disposal. The separation can greatly reduce the decay-heat and weight of the waste materials. The paper last explains the new concept of fuel cycle with some comments on important points in developing the new process (M.M.)

  2. Oriented active shape models.

    Science.gov (United States)

    Liu, Jiamin; Udupa, Jayaram K

    2009-04-01

    Active shape models (ASM) are widely employed for recognizing anatomic structures and for delineating them in medical images. In this paper, a novel strategy called oriented active shape models (OASM) is presented in an attempt to overcome the following five limitations of ASM: 1) lower delineation accuracy, 2) the requirement of a large number of landmarks, 3) sensitivity to search range, 4) sensitivity to initialization, and 5) inability to fully exploit the specific information present in the given image to be segmented. OASM effectively combines the rich statistical shape information embodied in ASM with the boundary orientedness property and the globally optimal delineation capability of the live wire methodology of boundary segmentation. The latter characteristics allow live wire to effectively separate an object boundary from other nonobject boundaries with similar properties especially when they come very close in the image domain. The approach leads to a two-level dynamic programming method, wherein the first level corresponds to boundary recognition and the second level corresponds to boundary delineation, and to an effective automatic initialization method. The method outputs a globally optimal boundary that agrees with the shape model if the recognition step is successful in bringing the model close to the boundary in the image. Extensive evaluation experiments have been conducted by utilizing 40 image (magnetic resonance and computed tomography) data sets in each of five different application areas for segmenting breast, liver, bones of the foot, and cervical vertebrae of the spine. Comparisons are made between OASM and ASM based on precision, accuracy, and efficiency of segmentation. Accuracy is assessed using both region-based false positive and false negative measures and boundary-based distance measures. The results indicate the following: 1) The accuracy of segmentation via OASM is considerably better than that of ASM; 2) The number of landmarks

  3. Orientation effects on indexing of electron backscatter diffraction patterns

    International Nuclear Information System (INIS)

    Nowell, Matthew M.; Wright, Stuart I.

    2005-01-01

    Automated Electron Backscatter Diffraction (EBSD) has become a well-accepted technique for characterizing the crystallographic orientation aspects of polycrystalline microstructures. At the advent of this technique, it was observed that patterns obtained from grains in certain crystallographic orientations were more difficult for the automated indexing algorithms to accurately identify than patterns from other orientations. The origin of this problem is often similarities between the EBSD pattern of the correct orientation and patterns from other orientations or phases. While practical solutions have been found and implemented, the identification of these problem orientations generally occurs only after running an automated scan, as problem orientations are often readily apparent in the resulting orientation maps. However, such an approach only finds those problem orientations that are present in the scan area. It would be advantageous to identify all regions of orientation space that may present problems for automated indexing prior to initiating an automated scan, and to minimize this space through the optimization of acquisition and indexing parameters. This work presents new methods for identifying regions in orientation space where the reliability of the automated indexing is suspect prior to performing a scan. This methodology is used to characterize the impact of various parameters on the indexing algorithm

  4. Value Orientation of the Modern Studentship

    Directory of Open Access Journals (Sweden)

    I. V. Tarasevitch

    2012-01-01

    Full Text Available The study is aimed at investigating the dynamics of students’ value orientation at the pedagogic higher school. The subject of the research incorporates the value-motivation sphere as being the component of students’ cognitive interest. The research methodology is based on the system determinism principle and combines the theoretical and practical substantiation of the value orientation problem as the main component of students’ cognitive interest. The research results referred to the professional activity values, growing year after year during the undergraduate course, can be taken into account in developing the value–motivation sphere of the studentship. The research shows that the proper psychological conditions created in the educational environment make the develop- ment of the value orientation system more successful. 

  5. Object-oriented programming for the biosciences.

    Science.gov (United States)

    Wiechert, W; Joksch, B; Wittig, R; Hartbrich, A; Höner, T; Möllney, M

    1995-10-01

    The development of software systems for the biosciences is always closely connected to experimental practice. Programs must be able to handle the inherent complexity and heterogeneous structure of biological systems in combination with the measuring equipment. Moreover, a high degree of flexibility is required to treat rapidly changing experimental conditions. Object-oriented methodology seems to be well suited for this purpose. It enables an evolutionary approach to software development that still maintains a high degree of modularity. This paper presents experience with object-oriented technology gathered during several years of programming in the fields of bioprocess development and metabolic engineering. It concentrates on the aspects of experimental support, data analysis, interaction and visualization. Several examples are presented and discussed in the general context of the experimental cycle of knowledge acquisition, thus pointing out the benefits and problems of object-oriented technology in the specific application field of the biosciences. Finally, some strategies for future development are described.

  6. γH2AX/53BP1 foci as a potential pre-treatment marker of HNSCC tumors radiosensitivity - preliminary methodological study and discussion

    Science.gov (United States)

    Falk, Martin; Horakova, Zuzana; Svobodova, Marketa; Masarik, Michal; Kopecna, Olga; Gumulec, Jaromir; Raudenska, Martina; Depes, Daniel; Bacikova, Alena; Falkova, Iva; Binkova, Hana

    2017-09-01

    In order to improve patients' post-treatment quality of life, a shift from surgery to non-surgical (chemo)radio-treatment is recognized in head and neck oncology. However, about half of HNSCC tumors are resistant to irradiation and an efficient marker of individual tumor radiosensitivity is still missing. We analyzed whether various parameters of DNA double strand break (DSB) repair determined in vitro can predict, prior to clinical treatment initiation, the radiosensitivity of tumors. We compared formation and decrease of γH2AX/53BP1 foci in 48 h after irradiating tumor cell primocultures with 2 Gy of γ-rays. To better understand complex tumor behavior, three different cell type primocultures - CD90-, CD90+, and a mixed culture of these cells - were isolated from 1 clinically radioresistant, 2 radiosensitive, and 4 undetermined HPV-HNSCC tumors and followed separately. While DSB repair was delayed and the number of persisting DSBs increased in the radiosensitive tumors, the results for the radioresistant tumor were similar to cultured normal human skin fibroblasts. Hence, DSB repair kinetics/efficiency may correlate with clinical response to radiotherapy for a subset of HNSCC tumors but the size (and therefore practical relevance) of this subset remains to be determined. The same is true for contribution of different cell type primocultures to tumor radioresistance.

  7. A Community-Oriented Approach to Breast Cancer in a Low-Resource Setting: Improving Awareness, Early Detection and Treatment of Breast Cancer in Tajikistan.

    Science.gov (United States)

    Talib, Zohray; Shukurbekova, Irina; Sadonshoeva, Guldarbogh; Alibekov, Alibek; Jamshedov, Nekruz; Moloo, Zahir; Welji, Almas; Amersi, Farin; Muhammad, Aliya Amin; Jiwani, Aliya; Rais, Sheliza; Nazrishoeva, Akoyat; Ilnazarova, Surayo; Nuridinova, Shifo; Ukani, Hafiza; Alwani, Shireen; Saleh, Mansoor

    2016-05-01

    Breast cancer is one of the most common cancers and causes of death in females in Tajikistan; yet less than half of the adult women in Tajikistan have heard of breast cancer. Limited access to health care contributes to late stage presentation. We developed a public-private partnership to implement a breast cancer awareness intervention in a low-resource community in Khorog, Tajikistan. We trained local health professionals in clinical breast care and conducted a breast cancer screening and treatment program. The partnership involved visiting USA-based health professionals working alongside local health care providers (HCP) in the continuum of breast care-from education to the diagnostic evaluation and management of detected breast abnormalities. Patient data were collected using a web-based program (VirtualDoc). Twenty-four HCP received didactic and clinical breast examination training. 441 women underwent clinical breast evaluation. 74 (17%) had abnormal exams and underwent additional diagnostic procedures. We identified six (1.4%) cases of breast cancer (all locally advanced) and two women had benign fibroadenomas. All women with cancer underwent modified radical mastectomy, while the fibroadenomas were treated by cosmetically appropriate lumpectomy. Five of six subjects with cancer were previously aware of their breast lump and three had recently seen a family medicine (FM) doctor. Health systems assessment revealed availability of diagnostic equipment but lack of well-trained operators and clinician interpreters. We were successful in integrating clinical breast exams into the routine care of female patients by local FM doctors and in the process, achieved a better understanding of existing risk factors and barriers to breast cancer care. This public-private partnership, leveraging the technical expertise of visiting health professionals, demonstrates how a focused onsite training and awareness program can provide sustained improvements in breast care in a low

  8. Queering canons. Methodological heteronormativities and queer inquietudes

    Directory of Open Access Journals (Sweden)

    Cirus Rinaldi

    2015-08-01

    Full Text Available The aim of this study is to present a series of epistemological and methodological reflections on the use of qualitative research methods in the study of non-normative sexualities. Particular emphasis will be highlighting the needs to reconsider queerly sociological oriented methods and methodology, paying attention to researcher’s ambiguous role, her body and emotions in the permanent reflexive research process and in encounters with the (co-researched. Normal 0 21 false false false ES-AR X-NONE X-NONE Melamine-based dendrimer amine-modified magnetic nanoparticles as an efficient Pb(II) adsorbent for wastewater treatment: Adsorption optimization by response surface methodology.

    Science.gov (United States)

    Jiryaei Sharahi, Fatemeh; Shahbazi, Afsaneh

    2017-12-01

    Magnetic Fe 3 O 4 nanoparticles with an average diameter of 64 nm was synthesized solvothermically and subsequently modified with melamine-based dendrimer amine (MDA-Fe 3 O 4 ) via grafting method. The synthesized materials were characterized using DLS, SEM, XRD, FTIR, VSM, TGA and elemental analysis techniques. The MDA-Fe 3 O 4 was employed for the efficient removal of Pb(II) ions from an aqueous solution. The adsorption efficiency was investigated in relation to the independent variables of Pb(II) concentration (80-250 mg L -1 ), pH of the solution (3-7), adsorbent dosage (0.1-0.5 g L -1 ) and temperature (10-40 °C) via a central composite design (CCD) using response surface methodology (RSM). The significance of independent variables and their interactions was tested using ANOVA at a 95% confidence limit (α = 0.05). A second-order quadratic model was established to predict the adsorption efficiency. Under the optimum condition (initial Pb(II) concentration = 110 mg L -1 , MDA-Fe 3 O 4 dosage = 0.49 g L -1 , pH = 5 and temperature = 30 °C) a removal percentage of 85.6% was obtained. The isotherm data fitted well to the Freundlich model within the concentration range of the experimental study. A maximum adsorption capacity of 333.3 mg g -1 was predicted by the Langmuir model. The adsorption rate of Pb(II) ions onto MDA-Fe 3 O 4 was in good agreement with the pseudo-second-order model (R 2  = 0.999; k 2  = 4.7 × 10 -4  g mg -1 min -1 ). Thermodynamically, adsorption was spontaneous and endothermic. The MDA-Fe 3 O 4 was successfully regenerated using 0.3 M HCl with little loss of adsorption capacity (≈7%) for five successive adsorption cycles. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Withdrawal-oriented therapy for smokers.

    Science.gov (United States)

    Hajek, P

    1989-06-01

    The treatment approach of the Maudsley Hospital Smokers Clinic is described. It stems from the notion that smokers seeking help are dependent on nicotine, and that withdrawal discomfort is a major block to their success in quitting. Accordingly, therapy focuses on helping clients overcome nicotine deprivation. It uses nicotine replacement and a special format of group treatment. Details are given of preparation of clients, use of nicotine chewing gum, use of group-oriented groupwork, use of information about withdrawal, and training in withdrawal-oriented therapy. Data are presented concerning characteristics of the clientele, treatment adherence, and treatment results. A number of controversial issues are addressed, such as the optimal duration of treatment, timing of the quit date, the value of educational input, and the value of individualization of treatment goals.

  10. Action research methodology in clinical pharmacy

    DEFF Research Database (Denmark)

    Nørgaard, Lotte Stig; Sørensen, Ellen Westh

    2016-01-01

    Introduction The focus in clinical pharmacy practice is and has for the last 30-35 years been on changing the role of pharmacy staff into service orientation and patient counselling. One way of doing this is by involving staff in change process and as a researcher to take part in the change process...... by establishing partnerships with staff. On the background of the authors' widespread action research (AR)-based experiences, recommendations and comments for how to conduct an AR-study is described, and one of their AR-based studies illustrate the methodology and the research methods used. Methodology AR...... is defined as an approach to research which is based on a problem-solving relationship between researchers and clients, which aims at both solving a problem and at collaboratively generating new knowledge. Research questions relevant in AR-studies are: what was the working process in this change oriented...

  11. Implementing Strategic Orientation

    Science.gov (United States)

    Fischer, Arthur K.; Brownback, Sarah

    2012-01-01

    An HRM case dealing with problems and issues of setting up orientation programs which align with corporate strategy. Discussion concerns how such a case can be used to exhibit the alignment between HRM and business strategy.

  12. Ultra wideband antennas design, methodologies, and performance

    CERN Document Server

    Galvan-Tejada, Giselle M; Jardón Aguilar, Hildeberto

    2015-01-01

    Ultra Wideband Antennas: Design, Methodologies, and Performance presents the current state of the art of ultra wideband (UWB) antennas, from theory specific for these radiators to guidelines for the design of omnidirectional and directional UWB antennas. Offering a comprehensive overview of the latest UWB antenna research and development, this book:Discusses the developed theory for UWB antennas in frequency and time domainsDelivers a brief exposition of numerical methods for electromagnetics oriented to antennasDescribes solid-planar equivalen

  13. Musical training of coaches in aesthetic-oriented sports

    Directory of Open Access Journals (Sweden)

    Irina Belenkaya

    2016-06-01

    Full Text Available Purpose: to justify theoretically the need for musical training of coaches in aesthetic-oriented sports. Material & Methods: theoretical analysis and generalization of scientific and methodological literature, pedagogical supervision. Results: the main directions of musical training of coaches in aesthetic-orientated sports were reviewed. It was discovered that in these types of sports coaches must have specific musical and rhythmic motor skills involving the use of musical accompaniment as a methodological technique for training sessions. The means of music and rhythmic education, which facilitate effective musical training of coaches in aesthetic-oriented sports, were determined. Conclusions: the necessity of improving the teaching methods of the subject "music and rhythmic education" as part of the musical training of coaches in aesthetic-orientated sports, was theoretically justified.

  14. Neural Networks Methodology and Applications

    CERN Document Server

    Dreyfus, Gérard

    2005-01-01

    Neural networks represent a powerful data processing technique that has reached maturity and broad application. When clearly understood and appropriately used, they are a mandatory component in the toolbox of any engineer who wants make the best use of the available data, in order to build models, make predictions, mine data, recognize shapes or signals, etc. Ranging from theoretical foundations to real-life applications, this book is intended to provide engineers and researchers with clear methodologies for taking advantage of neural networks in industrial, financial or banking applications, many instances of which are presented in the book. For the benefit of readers wishing to gain deeper knowledge of the topics, the book features appendices that provide theoretical details for greater insight, and algorithmic details for efficient programming and implementation. The chapters have been written by experts ands seemlessly edited to present a coherent and comprehensive, yet not redundant, practically-oriented...

  15. Community-based intermittent mass testing and treatment for malaria in an area of high transmission intensity, western Kenya: study design and methodology for a cluster randomized controlled trial.

    Science.gov (United States)

    Samuels, Aaron M; Awino, Nobert; Odongo, Wycliffe; Abong'o, Benard; Gimnig, John; Otieno, Kephas; Shi, Ya Ping; Were, Vincent; Allen, Denise Roth; Were, Florence; Sang, Tony; Obor, David; Williamson, John; Hamel, Mary J; Patrick Kachur, S; Slutsker, Laurence; Lindblade, Kim A; Kariuki, Simon; Desai, Meghna

    2017-06-07

    Most human Plasmodium infections in western Kenya are asymptomatic and are believed to contribute importantly to malaria transmission. Elimination of asymptomatic infections requires active treatment approaches, such as mass testing and treatment (MTaT) or mass drug administration (MDA), as infected persons do not seek care for their infection. Evaluations of community-based approaches that are designed to reduce malaria transmission require careful attention to study design to ensure that important effects can be measured accurately. This manuscript describes the study design and methodology of a cluster-randomized controlled trial to evaluate a MTaT approach for malaria transmission reduction in an area of high malaria transmission. Ten health facilities in western Kenya were purposively selected for inclusion. The communities within 3 km of each health facility were divided into three clusters of approximately equal population size. Two clusters around each health facility were randomly assigned to the control arm, and one to the intervention arm. Three times per year for 2 years, after the long and short rains, and again before the long rains, teams of community health volunteers visited every household within the intervention arm, tested all consenting individuals with malaria rapid diagnostic tests, and treated all positive individuals with an effective anti-malarial. The effect of mass testing and treatment on malaria transmission was measured through population-based longitudinal cohorts, outpatient visits for clinical malaria, periodic population-based cross-sectional surveys, and entomological indices.

  16. Assessing HIV and AIDS treatment safety and health-related quality of life among cohort of Malaysian patients: a discussion on methodological approach.

    Science.gov (United States)

    Syed, Imran Ahmed; Syed Sulaiman, Syed Azhar; Hassali, Mohammad Azmi; Lee, Christopher K C

    2015-10-01

    Health-related quality of life (HRQoL) is increasingly recognized as an important outcome and as a complement to traditional biological end points of diseases such as mortality. Unless there is a complete cure available for HIV/AIDS, development and implementation of a reliable and valid cross cultural quality of life measure is necessary to assess not only the physical and medical needs of HIV/AIDS people, but their psychological, social, environmental, and spiritual areas of life. A qualitative exploration of HIV/AIDS patients' understanding, perceptions and expectations will be carried out with the help of semi structured interview guide by in depth interviews, while quantitative assessment of patient reported adverse drug reactions and their impact on health related quality of life will be carried out by using data collection tool comprising patient demographics, SF-12, Naranjo scale, and a clinical data sheet. The findings may serve as baseline QOL data of people living with HIV/AIDS in Malaysia and also a source data to aid construction of management plan to improve HIV/AIDS patients' QOL. It will also provide basic information about HIV/AIDS patients' perceptions, expectations and believes towards HIV/AIDS and its treatment which may help in designing strategies to enhance patients' awareness which in turn can help in addressing issues related to compliance and adherence. © 2013 John Wiley & Sons Ltd.

  17. The effects of paradigmatic orientations of education research and discourse

    Science.gov (United States)

    Smithson, John Lawrence

    This essay presents an examination of contemporary disputes over methodological and epistemological foundations underlying inquiry within the field of education research; investigating the obstacles to communication and understanding found in scholarly exchanges occurring across competing paradigmatic orientations. Terminological challenges to cross-paradigmatic communication are examined, identifying three specific terminological difficulties, referred to as homonym, contextual, and onti-stemic problems. Nicholas Burbules' model of dialogue, based upon characteristics of convergence, divergence, inclusive and critical traits, is adopted and applied to a sample of cross-paradigmatic exchanges found in recent educational research journals. Examination of those exchanges reveals certain strategies associated with cross-paradigmatic communication. These strategies, labeled as trivialization, caricaturization, and re-direction, are shown to be detrimental to the mutual understanding of the interlocutors. The model is then extended to address examples of paradigmatic orientations within methodological and epistemological contexts in order to consider the relationship between the various orientations represented in the literature of interest. Methodological and epistemological orientations are shown to be loosely coupled, with unexpected shifts in paradigmatic values found among researchers' methodological and epistemological commitments. Finally, the nature of the relationship between competing paradigmatic orientations is examined, with particular attention given to four types of incommensurability (ontological, linguistic, epistemological, and values incommensurability). I conclude that, though difficult, cross-paradigmatic communication is necessary in order to provide a multi-paradigmatic perspective that takes us beyond the fractured picture of educational phenomena available from current research approaches.

  18. Using an innovative mixed method methodology to investigate the appropriateness of a quantitative instrument in an African context: Antiretroviral treatment and quality of life.

    Science.gov (United States)

    Greeff, Minrie; Chepuka, Lignet M; Chilemba, Winnie; Chimwaza, Angela F; Kululanga, Lucy I; Kgositau, Mabedi; Manyedi, Eva; Shaibu, Sheila; Wright, Susan C D

    2014-01-01

    The relationship between quality of life (QoL) and antiretroviral treatment (ART) has mainly been studied using quantitative scales often not appropriate for use in other contexts and without taking peoples' lived experiences into consideration. Sub-Saharan Africa has the highest incidence of HIV and AIDS yet there is paucity in research done on QoL. This research report is intended to give an account of the use of a mixed method convergent parallel design as a novice approach to evaluate an instrument's context specificity, appropriateness and usefulness in another context for which it was designed. Data were collected through a qualitative exploration of the experiences of QoL of people living with HIV or AIDS (PLHA) in Africa since being on ART, as well as the quantitative measurements obtained from the HIV/AIDS-targeted quality of life (HAT-QoL) instrument. This study was conducted in three African countries. Permission and ethical approval to conduct the study were obtained. Purposive voluntary sampling was used to recruit PLHA through mediators working in community-based HIV/AIDS organisations and health clinics. Interviews were analysed through open coding and the quantitative data through descriptive statistics and the Cronbach's alpha coefficient. A much wider range and richness of experiences were expressed than measured by the HAT-QoL instrument. Although an effective instrument for use in the USA, it was found not to be sensitive, appropriate and useful in an African context in its present form. The recommendations focus on adapting the instrument using the data from the in-depth interviews or to develop a context-sensitive instrument that could measure QoL of PLHA in Africa.

  19. Metodología para la localización de un parque de tratamiento y disposición final de residuos sólidos de tipo regional desde una perspectiva multidimensional Methodology for the location of a treatment and solid waste disposal regional park, from a multidimensional perspective

    Directory of Open Access Journals (Sweden)

    Diana Elizabeth Valencia Londoño

    2010-07-01

    Full Text Available El manejo y disposición final de los residuos sólidos en el oriente antioqueño siempre ha sido una preocupación desde CORNARE y los entes territoriales.El artículo presenta los hallazgos de una investigación realizado por el grupo proyecto Ciudad de la facultad de Artes Integradas de la Universidad de San Buenaventura, cofinanciado por CORNARE, cuyo objetivo es presentar la metodología elaborada para la determinación de las áreas potenciales para el asentamiento de un parque de tratamiento y disposición final de residuos sólidos de tipo regional, teniendo como soporte la descripción, caracterización y análisis del ambiente (abiótico, biótico y socioeconómico en la subregión Valles de San Nicolás. Dicha propuesta se basa en un análisis matricial combinado con una herramienta SIG, que permitió evaluar diferentes sitios desde su viabilidad, ambiental, social, económica y física y entregar tanto a las Administraciones municipales como a la Corporación una estrategia metodológica que, incorporando lo planteado en el decreto 838, permita una toma de decisiones territoriales acertadas.The issue of handling and disposal of solid waste in eastern Antioquia has always been a topic of special concern and attention from CORNARE and local authorities. This article presents the findings of a project conducted by Universidad de San Buenaventura, School of Arts, City Project Group, founded by CORNARE, which aims to present the methodology developed for the identification of potential areas for the settlement of a park of Treatment and Disposal of Solid Waste Regional Type, having as support the description, characterization and analysis of (abiotic, biotic, and socio-economic environment in Valles de San Nicolás region. This proposal is based on a matrix analysis tool combined with GIS, which allowed us to evaluate different sites from its environmental, social, economic, and physical feasibility, and deliver to both local governments

  1. Air pollution monitoring - a methodological approach

    International Nuclear Information System (INIS)

    Trajkovska Trpevska, Magdalena

    2002-01-01

    Methodology for monitoring the emission of polluters in the air is a complex concept that in general embraces following fazes: sampling, laboratory treatment, and interpretation of results. In Company for technological and laboratory investigation and environmental protection - Mining Institute Skopje, the control of emission of polluters in the air is performing according methodology based in general on the recommendation of standard VDI 2.066 prescribe from Ministry of Ecology in Germany, because adequate legislation in our country does not exist. In this article the basic treatment of methodology for the air polluters emission control is presented. (Original)

  2. Cooperative learning as a methodology for inclusive education development

    Directory of Open Access Journals (Sweden)

    Yolanda Muñoz Martínez

    2017-06-01

    Full Text Available This paper presents the methodology of cooperative learning as a strategy to develop the principles of inclusive education. It has a very practical orientation, with the intention of providing tools for teachers who want to implement this methodology in the classroom, starting with a theoretical review, and then a description of a case in which they have worked this methodology for 5 years. We describe specific activities and ways of working with students, later reaching conclusions on the implementation of the methodology.

  3. Towards a Methodology for the Design of Multimedia Public Access Interfaces.

    Science.gov (United States)

    Rowley, Jennifer

    1998-01-01

    Discussion of information systems methodologies that can contribute to interface design for public access systems covers: the systems life cycle; advantages of adopting information systems methodologies; soft systems methodologies; task-oriented approaches to user interface design; holistic design, the Star model, and prototyping; the…

  4. Tamsulosin treatment for benign prostatic hyperplasia and risk of severe hypotension in men aged 40-85 years in the United States: risk window analyses using between and within patient methodology.

    Science.gov (United States)

    Bird, Steven T; Delaney, Joseph A C; Brophy, James M; Etminan, Mahyar; Skeldon, Sean C; Hartzema, Abraham G

    2013-11-05

    To characterize risk of hypotension requiring admission to hospital in middle aged and older men treated with tamsulosin for benign prostatic hyperplasia. Population based retrospective cohort study (between patient methodology) and self controlled case series (within patient methodology). Healthcare claims data from the IMS Lifelink database in the United States. Men aged 40-85 years with private US healthcare insurance entering the cohort at their first dispensing for tamsulosin or for a 5α reductase inhibitor (5ARI) between January 2001 and June 2011 after a minimum of six months' enrolment. Hypotension requiring admission to hospital. Cox proportional hazards models estimated rate ratios at time varying intervals during follow-up: weeks 1-4, 5-8, and 9-12 after tamsulosin initiation; weeks 1-4, 5-8, and 9-12 after restarting tamsulosin (after a four week gap); and maintenance tamsulosin treatment (remaining exposed person time). Covariates included age, calendar year, demographics, antihypertensive use, healthcare use, and a Charlson comorbidity score. A self controlled case series, having implicit control for time invariant covariates, was additionally conducted. Among 383,567 new users of study drugs (tamsulosin 297,596; 5ARI 85,971), 2562 admissions to hospital for severe hypotension were identified. The incidence for hypotension was higher for tamsulosin (42.4 events per 10,000 person years) than for 5ARIs (31.3 events per 10,000 person years) or all accrued person time (29.1 events per 10,000 person years). After tamsulosin initiation, the cohort analysis identified an increased rate of hypotension during weeks 1-4 (rate ratio 2.12 (95% confidence interval 1.29 to 3.04)) and 5-8 (1.51 (1.04 to 2.18)), and no significant increase at weeks 9-12. The rate ratio for hypotension also increased at weeks 1-4 (1.84 (1.46 to 2.33)) and 5-8 (1.85 (1.45 to 2.36)) after restarting tamsulosin, as did maintenance tamsulosin treatment (1.19 (1.07 to 1.32)). The self

  5. Oriental Medical Treatment of chronic Acalculous Cholecystitis

    Directory of Open Access Journals (Sweden)

    Hae-Yeon Lee

    2004-12-01

    Full Text Available Chronic acalculous cholecystitis gets possession of about 12 to 13 percent of patients with chronic cholecystitis. Pathologically it is characterised by chronic inflammation and thickening of the gallbladder wall but doesn't come across stones. Clinical symptoms are vague and include abdominal discomfort and distension, nausea, flatulence and intolerance of fatty foods. A patient on chronic acalculous cholecystitis diagnosed from his clinical symtoms and abdominal ultrasonogram was treated by Geonbihwan, acupuncture and herbal acupuncture. Satisfactory symptomatic improvement was achieved and findings of abdominal ultrasonogram came also normal.

  6. Scenario development methodologies

    International Nuclear Information System (INIS)

    Eng, T.; Hudson, J.; Stephansson, O.

    1994-11-01

    In the period 1981-1994, SKB has studied several methodologies to systematize and visualize all the features, events and processes (FEPs) that can influence a repository for radioactive waste in the future. All the work performed is based on the terminology and basic findings in the joint SKI/SKB work on scenario development presented in the SKB Technical Report 89-35. The methodologies studied are a) Event tree analysis, b) Influence diagrams and c) Rock Engineering Systems (RES) matrices. Each one of the methodologies is explained in this report as well as examples of applications. One chapter is devoted to a comparison between the two most promising methodologies, namely: Influence diagrams and the RES methodology. In conclusion a combination of parts of the Influence diagram and the RES methodology is likely to be a promising approach. 26 refs

  7. Reliability Centered Maintenance - Methodologies

    Science.gov (United States)

    Kammerer, Catherine C.

    2009-01-01

    Journal article about Reliability Centered Maintenance (RCM) methodologies used by United Space Alliance, LLC (USA) in support of the Space Shuttle Program at Kennedy Space Center. The USA Reliability Centered Maintenance program differs from traditional RCM programs because various methodologies are utilized to take advantage of their respective strengths for each application. Based on operational experience, USA has customized the traditional RCM methodology into a streamlined lean logic path and has implemented the use of statistical tools to drive the process. USA RCM has integrated many of the L6S tools into both RCM methodologies. The tools utilized in the Measure, Analyze, and Improve phases of a Lean Six Sigma project lend themselves to application in the RCM process. All USA RCM methodologies meet the requirements defined in SAE JA 1011, Evaluation Criteria for Reliability-Centered Maintenance (RCM) Processes. The proposed article explores these methodologies.

  8. Methodology of clinical trials evaluating the incorporation of new drugs in the first-line treatment of patients with diffuse large B-cell lymphoma (DLBCL): a critical review.

    Science.gov (United States)

    Iacoboni, G; Zucca, E; Ghielmini, M; Stathis, A

    2018-05-01

    The first-line treatment of diffuse large B-cell lymphoma (DLBCL) is the combination of rituximab with CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy, curing approximately 60% of patients. Many clinical trials have been carried out over the last 10 years trying to improve the results of this treatment, but the appropriateness of their planning strategies could be rediscussed. Reports of phase III trials evaluating the addition of molecularly targeted agents or new monoclonal antibodies to the classic R-CHOP backbone in first-line induction or maintenance treatment were reviewed. The trial design, primary end point, number of patients enrolled, patient selection criteria, treatment schedule and results were registered for each one. In addition, the phases I and II trials which preceded these phase III trials were also reviewed. Among six phase III trials with results, only one trial evaluating lenalidomide maintenance after response to R-CHOP induction was positive and reached its primary end point. The other five trials did not show an improved outcome with the addition of the new agent. The preceding phases I and II trials were very heterogeneous in their end points and design. Even though most of these trials were considered positive, thus encouraging further investigation, so far they failed to predict the results of the subsequent phase III trials. The standard of care for DLBCL is still R-CHOP. Phase I/II trials failed to predict the results of subsequent phase III trials evaluating non-chemotherapeutic agents added to R-CHOP. The methodology of phase II trials evaluating new agents in DLBCL needs to be better defined in the future.

  9. Cultural Orientation and Interdisciplinarity

    DEFF Research Database (Denmark)

    Nielsen, Sofie Søndergaard

    2004-01-01

    I begin the article with an account of the background to the German debate on ‘Literaturwissenschaft als Kulturwissenschaft’, including the introduction of the concept of ’cultural orientation’ as a strategy for achieving interdisciplinarity. This is followed by a consideration of the discussion ...... of the object of literary studies as a way of defining the disciplinarity or identity of literary studies. Finally I summarize some of the characteristics of culturally orientated literary studies.......I begin the article with an account of the background to the German debate on ‘Literaturwissenschaft als Kulturwissenschaft’, including the introduction of the concept of ’cultural orientation’ as a strategy for achieving interdisciplinarity. This is followed by a consideration of the discussion...

  10. Entrepreneurial orientation in a franchised home entertainment system

    Directory of Open Access Journals (Sweden)

    A Maritz

    2014-07-01

    Full Text Available This paper fills the gap in the research undertaken into the entrepreneurial orientation of franchisees. The study identifies entrepreneurial orientation within a defined franchise system, using the entrepreneurial character theme matrix developed by Thompson (2002. Research methodology comprises the survey approach, using electronic media and Surveypro analysis (Dillman, 2000. Hypothesis tests highlight the absence of statistically significant entrepreneurial orientation in the franchise system, despite a significant orientation in a multiple-outlet proposition analysis. Conclusions and recommendations include mobilising and communicating the action factors associated with entrepreneurial orientation, involving all franchisees within the system. Managerial implications include the motivation of developing multiple-outlet franchise systems. Future research involves broadening the data set across industries and borders.

  11. Automated determination of crystal orientations from electron backscattering patterns

    DEFF Research Database (Denmark)

    Lassen, Niels Christian Krieger

    1994-01-01

    of the position of the bands or the zone axes of EBSPs have existed for several years now. Until recently, however, the localization of either the bands or the zone axes of EBSPs has required the valuable time and attention of a human operator, thus obviously limiting the amounts of orientation data that can...... quantitatively is therefore described. Presently, little is known about the uncertainty of the lattice orientations which can be measuted from EBSPs. This subject will be discussed in detail in this thesis. With the application of newly developed statistical methods for analyzing orientation data...... it will be shown how the relative precision of lattice orientations measured from EBSPs can be described. By applying this methodology to a large number of EBSPs of varying quality it is demonstrated that the precision of automatically measured crystal orientations is comparable to the precision obtained, when...

  12. Age and Value Orientations

    Directory of Open Access Journals (Sweden)

    Asya Kh. Kukubayeva

    2013-01-01

    Full Text Available The present article deals with value orientations and their role in men’s lives, particularly, in young people’s lives. This notion was introduced by the American theoretical sociologist T. Parsons, one of the creators of modern theoretical sociology. The scientist made an attempt to construct the structural and analytical theory of social action, combining personal interests (needs and aims and situation, it takes place in. The issue of value orientations remains acute for psychology. Herein we have considered several most important works, relating to the considered issue. Age aspects of young people’s value orientations are of peculiar interest to us. When analyzing this phenomenon, one should take into consideration the psychological formations, inhere for a certain age. In fact every age has its unique structure, which may change when passing from one development stage to another. Basing on this fact, we’ve considered the values, depending on the age features of the youth, relying upon the works of the scientists, working with different categories of the youth, such as: teenagers, students, children of different nationalities. It is not surprising that most scientists have come to the conclusion that the chief role in value orientation belongs to a family, originates in relations with parents and teachers. The positive reinforcement to the future develops throughout life in accordance with a lifestyle of a family, society and political situation in a state.Life orientations as a type of value orientations show different types of young people’s preferences. Value structure of its consciousness has its own specific character, depending on the age peculiarities. The dynamics of the transition from one age to another is accompanied with the reappraisal of values, eventually, influencing the life strategy of the future generation

  13. Object-oriented communications

    International Nuclear Information System (INIS)

    Chapman, L.J.

    1989-01-01

    OOC is a high-level communications protocol based on the object-oriented paradigm. OOC's syntax, semantics, and pragmatics balance simplicity and expressivity for controls environments. While natural languages are too complex, computer protocols are often insufficiently expressive. An object-oriented communications philosophy provides a base for building the necessary high-level communications primitives like I don't understand and the current value of X is K. OOC is sufficiently flexible to express data acquisition, control requests, alarm messages, and error messages in a straightforward generic way. It can be used in networks, for inter-task communication, and even for intra-task communication

  14. Institutional Assessment of Environmentally Oriented Subsoil Use

    Directory of Open Access Journals (Sweden)

    Irina Gennadyevna Polyanskaya

    2017-06-01

    Full Text Available The article solves two relevant problems related to the implementation of the institutional assessment of environmentally oriented subsoil use: 1 the definition of the ‘environmental security’ and 2 the determination of the development level of institutional bases of environmentally oriented subsoil use including the institutional capacity of subsoil use and institutional capacity of environmental security. The article shows an analysis of the existing definitions of “environmental security” and offers the own one. Despite the significant national and foreign experience in the institutional capacity assessment of various processes, there are still some difficulties in defining and measuring the institutional capacity. We eliminate these difficulties by employing 1 original factors, previously identified, and the content of the “institutional capacity” term; 2 quality characteristics for the institutional capacity assessment of the process regulated at the macroeconomic level, and 3 a consistent methodological tool for the institutional assessment of environmentally oriented subsoil use. The study is based on the hypothesis of the necessity of legal and discreet state intervention in the process of subsoil use. Therefore, we identify the evaluation indicator of state regulation in the environmentally oriented subsoil use as the institutional capacity level calculated by using the fuzzy-set theory. As a result, the institutional capacity levels of the environmentally oriented subsoil use have been defined for both the transport corridor «Arctic-Central Asia» and for the countries composing it. The obtained values of the assessment of institutional capacity levels of the environmentally oriented subsoil use can serve as a basis for identifying the vector of its increase

  15. QUANTIFYING WILDLIFE ORIENTATION

    African Journals Online (AJOL)

    environment (P);. Attitudes expressed towards the natural environment (A);. Activity, or the involvement of a person in conservation actions in the broader sense {I). Different combinations of these functions give rise to four typologies of orientation. (Newgard et al., 1986) in the following way: TYPOLOGY. CHARACTERISTICS.

  16. Orientals and Orientalists

    DEFF Research Database (Denmark)

    Reade, Julian

    2004-01-01

    Reviews three books on archaeology. "Possessors and Possessed: Museums, Archaeology, and the Visualization of History in the Late Ottoman Empire," by Wendy M. K. Shaw; "Orientalism and Visual Culture: Imagining Mesapotamia in Nineteenth-Century Europe," by Frederick N. Bohrer; "Empires of the Pla......: Henry Rawlinson and the Lost Languages of Babylon," by Lesley Adkins....

  17. Management oriented process

    International Nuclear Information System (INIS)

    2004-01-01

    ANAV decided to implement process-oriented management by adopting the U. S. NEI (Nuclear Electric Industry) model. The article describes the initial phases of the project, its current status and future prospects. The project has been considered as an improvement in the areas of organization and human factors. Recently, IAEA standard drafts are including processes as an accepted management model. (Author)

  18. Aspect-Oriented Programming

    NARCIS (Netherlands)

    Lopes, C.; Bergmans, Lodewijk; Lopes, C.

    1999-01-01

    Aspect-oriented programming is a promising idea that can improve the quality of software by reduce the problem of code tangling and improving the separation of concerns. At ECOOP’97, the first AOP workshop brought together a number of researchers interested in aspectorientation. At ECOOP’98, during

  19. Managing Entrepreneurial Orientation

    NARCIS (Netherlands)

    S. van Doorn (Sebastiaan)

    2012-01-01

    textabstractIn this dissertation, we evaluate the roles senior management teams and individual middle managers play in realizing the performance benefits of entrepreneurial orientations. We investigate the role of senior management teams by focusing on a sample of 9.000 firms in the Netherlands. The

  20. Component-oriented programming

    NARCIS (Netherlands)

    Bosch, J; Szyperski, C; Weck, W; Buschmann, F; Buchmann, AP; Cilia, MA

    2003-01-01

    This report covers the eighth Workshop on Component-Oriented Programming (WCOP). WCOP has been affiliated with ECOOP since its inception in 1996. The report summarizes the contributions made by authors of accepted position papers as well as those made by all attendees of the workshop sessions.

  1. Introduction to LCA Methodology

    DEFF Research Database (Denmark)

    Hauschild, Michael Z.

    2018-01-01

    In order to offer the reader an overview of the LCA methodology in the preparation of the more detailed description of its different phases, a brief introduction is given to the methodological framework according to the ISO 14040 standard and the main elements of each of its phases. Emphasis...

  2. Archetype modeling methodology.

    Science.gov (United States)

    Moner, David; Maldonado, José Alberto; Robles, Montserrat

    2018-03-01

    Clinical Information Models (CIMs) expressed as archetypes play an essential role in the design and development of current Electronic Health Record (EHR) information structures. Although there exist many experiences about using archetypes in the literature, a comprehensive and formal methodology for archetype modeling does not exist. Having a modeling methodology is essential to develop quality archetypes, in order to guide the development of EHR systems and to allow the semantic interoperability of health data. In this work, an archetype modeling methodology is proposed. This paper describes its phases, the inputs and outputs of each phase, and the involved participants and tools. It also includes the description of the possible strategies to organize the modeling process. The proposed methodology is inspired by existing best practices of CIMs, software and ontology development. The methodology has been applied and evaluated in regional and national EHR projects. The application of the methodology provided useful feedback and improvements, and confirmed its advantages. The conclusion of this work is that having a formal methodology for archetype development facilitates the definition and adoption of interoperable archetypes, improves their quality, and facilitates their reuse among different information systems and EHR projects. Moreover, the proposed methodology can be also a reference for CIMs development using any other formalism. Copyright © 2018 Elsevier Inc. All rights reserved.

  3. Menopause and Methodological Doubt

    Science.gov (United States)

    Spence, Sheila

    2005-01-01

    Menopause and methodological doubt begins by making a tongue-in-cheek comparison between Descartes' methodological doubt and the self-doubt that can arise around menopause. A hermeneutic approach is taken in which Cartesian dualism and its implications for the way women are viewed in society are examined, both through the experiences of women…

  4. VEM: Virtual Enterprise Methodology

    DEFF Research Database (Denmark)

    Tølle, Martin; Vesterager, Johan

    2003-01-01

    This chapter presents a virtual enterprise methodology (VEM) that outlines activities to consider when setting up and managing virtual enterprises (VEs). As a methodology the VEM helps companies to ask the right questions when preparing for and setting up an enterprise network, which works...

  5. The Methodology of Magpies

    Science.gov (United States)

    Carter, Susan

    2014-01-01

    Arts/Humanities researchers frequently do not explain methodology overtly; instead, they "perform" it through their use of language, textual and historic cross-reference, and theory. Here, methodologies from literary studies are shown to add to Higher Education (HE) an exegetical and critically pluralist approach. This includes…

  6. Views of general practice staff about the use of a patient-oriented treatment decision aid in shared decision making for patients with type 2 diabetes: A mixed-methods study.

    Science.gov (United States)

    Wildeboer, Anita; du Pon, Esther; Schuling, Jan; Haaijer-Ruskamp, Flora M; Denig, Petra

    2018-02-01

    Decision aids can be used to support shared decision making (SDM). A patient-oriented treatment decision aid (DA) was developed for type 2 diabetes but its use by general practice staff appeared to be limited. To explore views of practice staff towards SDM and the DA. A mixed-methods study within the Dutch PORTDA-diab trial. Included were 17 practices with staff members who were responsible for routine diabetes care and had worked with the DA, and 209 of their patients. Interviews were conducted focusing on applicability, usefulness and feasibility of the DA. Interviews were tape-recorded, transcribed verbatim and subjected to content analysis for identifying and classifying views. Patient-reported data about the use of the DA were collected. Associations between specific views and use of the DA were tested using Pearson point-biserial correlation. The majority of practice staff expressed positive views towards SDM, which was associated with making more use of the DA. Most of the staff expressed that the DA stimulated a two-way conversation. By using the DA, several became aware of their paternalistic approach. Some staff experienced a conflict with the content of the DA, which was associated with making less use of the DA. The DA was considered useful by practice staff to support SDM. A positive view towards SDM was a facilitator, whereas experiencing a conflict with the content of the DA was a barrier for making use of the DA. © 2017 The Authors Health Expectations Published by John Wiley & Sons Ltd.

  7. Multicriteria methodology for decision aiding

    CERN Document Server

    Roy, Bernard

    1996-01-01

    This is the first comprehensive book to present, in English, the multicriteria methodology for decision aiding In the foreword the distinctive features and main ideas of the European School of MCDA are outlined The twelve chapters are essentially expository in nature, but scholarly in treatment Some questions, which are too often neglected in the literature on decision theory, such as how is a decision made, who are the actors, what is a decision aiding model, how to define the set of alternatives, are discussed Examples are used throughout the book to illustrate the various concepts Ways to model the consequences of each alternative and building criteria taking into account the inevitable imprecisions, uncertainties and indeterminations are described and illustrated The three classical operational approaches of MCDA synthesis in one criterion (including MAUT), synthesis by outranking relations, interactive local judgements, are studied This methodology tries to be a theoretical or intellectual framework dire...

  8. NEW CO-EVOLUTION STRATEGIES OF THIRD MILLENNIUM; METHODOLOGICAL ASPECT

    Directory of Open Access Journals (Sweden)

    E. K. Bulygo

    2006-01-01

    Full Text Available The paper is devoted to an application of the co-evolution methodology to the social space. Principles of instability and non-linearity that are typical for contemporary natural science are used as a theoretical background of a new social methodology. Authors try to prove that the co-evolution strategy has a long pre-history in the ancient oriental philosophy and manifests itself in forms of modem culture

  9. Production and Reliability Oriented SOFC Cell and Stack Design

    DEFF Research Database (Denmark)

    Hauth, Martin; Lawlor, Vincent; Cartellieri, Peter

    2017-01-01

    The paper presents an innovative development methodology for a production and reliability oriented SOFC cell and stack design aiming at improving the stacks robustness, manufacturability, efficiency and cost. Multi-physics models allowed a probabilistic approach to consider statistical variations...... in production, material and operating parameters for the optimization phase. A methodology for 3D description of spatial distribution of material properties based on a random field models was developed and validated by experiments. Homogenized material models on multiple levels of the SOFC stack were...... and output parameters and to perform a sensitivity analysis were developed and implemented. The capabilities of the methodology is illustrated on two practical cases....

  10. APPLICATION FRAMEWORK IN ENGINEERING SERVICE ORIENTED ARCHITECTURE SYSTEM SERVICE

    Directory of Open Access Journals (Sweden)

    Ade Hodijah

    2017-03-01

    Full Text Available The Service Engineering (SE is understood as a framework to create innovative services in application development of information technology approach to Service Oriented Architecture (SOA. Implementing SOA is required methodology to identify services that can be used again in the application and organization of a company. in this research, software development model used is object-oriented methodologies, SOA itself is a collection consisting of tools, technologies, frameworks, and best practices that facilitate the implementation of a service quickly. in a study this uses the tools of Business Process Management System (BPMS to support the implementation of service-oriented software. the purpose of this study is to produce a model of activities and artifacts of the application software development models of the SE with a case study Rate Loans. Validation to the design of the model is done through testing of the software produced. The results showed that the application of the SE in the development of service-oriented software can use the object-oriented methodology by providing additional value-added analysis and redesign of business processes to be implemented on a BPMS. BPMS usage of the application of the SE on the SOA has the advantage of visualization in the management of business processes.

  11. Leader-Member Exchange, Learning Orientation and Innovative Work Behavior

    Science.gov (United States)

    Atitumpong, Aungkhana; Badir, Yuosre F.

    2018-01-01

    Purpose: This study aims to examine the effects of leader-member exchange (LMX) and employee learning orientation on employee innovative work behavior (IWB) through creative self-efficacy. Design/methodology/approach: Data have been collected from 337 employees and 137 direct managers from manufacturing sector. A hierarchical linear model has been…

  12. Personality, Organizational Orientations and Self-Reported Learning Outcomes

    Science.gov (United States)

    Bamber, David; Castka, Pavel

    2006-01-01

    Purpose: To identify competencies connecting personality, organizational orientations and self-reported learning outcomes (as measured by concise Likert-type scales), for individuals who are learning for their organizations. Design/methodology/approach: Five concise factor scales were constructed to represent aspects of personality. Three further…

  13. Object-Oriented Scientific Programming with Fortran 90

    Science.gov (United States)

    Norton, C.

    1998-01-01

    Fortran 90 is a modern language that introduces many important new features beneficial for scientific programming. We discuss our experiences in plasma particle simulation and unstructured adaptive mesh refinement on supercomputers, illustrating the features of Fortran 90 that support the object-oriented methodology.

  14. Uniframe: A Unified Framework for Developing Service-Oriented, Component-Based Distributed Software Systems

    National Research Council Canada - National Science Library

    Raje, Rajeev R; Olson, Andrew M; Bryant, Barrett R; Burt, Carol C; Auguston, Makhail

    2005-01-01

    .... It describes how this approach employs a unifying framework for specifying such systems to unite the concepts of service-oriented architectures, a component-based software engineering methodology...

  15. Treatment

    Directory of Open Access Journals (Sweden)

    Safaa M. Raghab

    2013-08-01

    The main goal of this study is to utilize a natural low cost material “as an accelerator additive to enhance the chemical treatment process using Alum coagulant and the accelerator substances were Perlite and Bentonite. The performance of the chemical treatment was enhanced using the accelerator substances with 90 mg/l Alum as a constant dose. Perlite gave better performance than the Bentonite effluent. The removal ratio for conductivity, turbidity, BOD and COD for Perlite was 86.7%, 87.4%, 89.9% and 92.8% respectively, and for Bentonite was 83.5%, 85.0%, 86.5% and 85.0% respectively at the same concentration of 40 mg/l for each.

  16. Synthesised model of market orientation-business performance relationship

    Directory of Open Access Journals (Sweden)

    G. Nwokah

    2006-12-01

    Full Text Available Purpose: The purpose of this paper is to assess the impact of market orientation on the performance of the organisation. While much empirical works have centered on market orientation, the generalisability of its impact on performance of the Food and Beverages organisations in the Nigeria context has been under-researched. Design/Methodology/Approach: The study adopted a triangulation methodology (quantitative and qualitative approach. Data was collected from key informants using a research instrument. Returned instruments were analyzed using nonparametric correlation through the use of the Statistical Package for Social Sciences (SPSS version 10. Findings: The study validated the earlier instruments but did not find any strong association between market orientation and business performance in the Nigerian context using the food and beverages organisations for the study. The reasons underlying the weak relationship between market orientation and business performance of the Food and Beverages organisations is government policies, new product development, diversification, innovation and devaluation of the Nigerian currency. One important finding of this study is that market orientation leads to business performance through some moderating variables. Implications: The study recommends that Nigerian Government should ensure a stable economy and make economic policies that will enhance existing business development in the country. Also, organisations should have performance measurement systems to detect the impact of investment on market orientation with the aim of knowing how the organisation works. Originality/Value: This study significantly refines the body of knowledge concerning the impact of market orientation on the performance of the organisation, and thereby offers a model of market orientation and business performance in the Nigerian context for marketing scholars and practitioners. This model will, no doubt, contribute to the body of

  17. For the Love of Science: Learning Orientation and Physical Science Success

    Science.gov (United States)

    Hazari, Zahra; Potvin, Geoff; Tai, Robert; Almarode, John

    2010-02-01

    An individual's motivational orientation serves as a drive to action and can influence their productivity. This study examines how the goal orientation of students towards the pursuit of their graduate degree in physics and chemistry influences their future success outcomes as practicing scientists. Two main orientations are focused on: performance (or ego/ability) orientation and learning (or task/mastery) orientation. The data was obtained as part of Project Crossover, which applied a mixed methodological approach to studying the transition from graduate student to scientist in the physical sciences. Using regression analysis on survey data from 2353 PhD holders in physics and chemistry, we found that individuals exhibiting a learning orientation were more productive than those exhibiting a performance orientation in terms of first-author publications and grant funding. Furthermore, given equal salary, learning-oriented physical scientists produced more first-author publications than average. )

  18. Value oriented strategic marketing

    Directory of Open Access Journals (Sweden)

    Milisavljević Momčilo

    2013-01-01

    Full Text Available Changes in today's business environment require companies to orient to strategic marketing. The company accepting strategic marketing has a proactive approach and focus on continuous review and reappraisal of existing and seeking new strategic business areas. Difficulties in achieving target profit and growth require turning marketing from the dominant viewpoint of the tangible product to creating superior value and developing relationships with customers. Value orientation implies gaining competitive advantage through continuous research and understanding of what value represents to the consumers and discovering new ways to meet their required values. Strategic marketing investment requires that the investment in the creation of values should be regularly reviewed in order to ensure a focus on customers with high profit potential and environmental value. This increases customer satisfaction and retention and long-term return on investment of companies.

  19. Flight calls and orientation

    DEFF Research Database (Denmark)

    Larsen, Ole Næsbye; Andersen, Bent Bach; Kropp, Wibke

    2008-01-01

    flight calls was simulated by sequential computer controlled activation of five loudspeakers placed in a linear array perpendicular to the bird's migration course. The bird responded to this stimulation by changing its migratory course in the direction of that of the ‘flying conspecifics' but after about......  In a pilot experiment a European Robin, Erithacus rubecula, expressing migratory restlessness with a stable orientation, was video filmed in the dark with an infrared camera and its directional migratory activity was recorded. The flight overhead of migrating conspecifics uttering nocturnal...... 30 minutes it drifted back to its original migration course. The results suggest that songbirds migrating alone at night can use the flight calls from conspecifics as additional cues for orientation and that they may compare this information with other cues to decide what course to keep....

  20. Research Methodology in Recurrent Pregnancy Loss

    DEFF Research Database (Denmark)

    Christiansen, Ole B

    2014-01-01

    The aim of this article is to highlight pitfalls in research methodology that may explain why studies in recurrent pregnancy loss (RPL) often provide very divergent results. It is hoped that insight into this issue may help clinicians decide which published studies are the most valid. It may help...... researchers to eliminate methodological flaws in future studies, which may hopefully come to some kind of agreement about the usefulness of diagnostic tests and treatments in RPL....

  1. The development of symptoms-oriented operating procedures

    International Nuclear Information System (INIS)

    Colquhoun, R.

    1983-04-01

    Until recently the formal treatment of control room procedures for nuclear power plant upset conditions has been event-oriented. The demise of Three Mile Island, Unit 2, caused the American industry to recognize the pitfalls inherent in relying totally on event-oriented procedures, and led to the initiation of a program for the development of a symptoms-oriented approach for handling upset conditions. The U.S. program has been independently paralleled by a Canadian program. This paper describes the development of the Canadian symptoms-oriented philosophy and identifies the relevance of a generic symptoms based emergency procedure to current operating practices

  2. Cerro Largo South orientation

    International Nuclear Information System (INIS)

    Pradier, B.

    1982-01-01

    This work is about Cerro Largo South orientation. The site is located in the northeast of Uruguay in the south of Melo city, Department of Cerro Largo. The study was carried out in the young edge socket in the East side of a small valley. This metamorphic socket constituted by gneisses and crystalline limestone are in contact with upper carboniferous formations and basal deposits composed by sandstones and conglomerates

  3. Editorial: International Entrepreneurial Orientation

    OpenAIRE

    Krzysztof Wach

    2015-01-01

    In recent decades, both the theory of internationalisation of the firm and/or the theory of international business have developed. Recent developments in international business studies prove that entrepreneurial orientation (EO) emerges as one of the important potential factors contributing to the intensification of the processes of internationalisation of the firm (Etemad, 2015; Gupta & Gupta, 2015). It seems that international entrepreneurship (IE) has been flourishing. The general theory o...

  4. Recovery orientation in mental health inpatient settings

    DEFF Research Database (Denmark)

    Waldemar, Anna Kristine; Esbensen, Bente Appel; Korsbek, Lisa

    2018-01-01

    Offering mental health treatment in line with a recovery-oriented practice has become an objective in the mental health services in many countries. However, applying recovery-oriented practice in inpatient settings seems challenged by unclear and diverging definitions of the concept......-structured interviews were conducted with 14 inpatients from two mental health inpatient wards using an interview guide based on factors from the Recovery Self-Assessment. Qualitative content analysis was applied in the analysis. Six themes covering the participants’ experiences were identified. The participants felt...... accepted and protected in the ward and found comfort in being around other people but missed talking and engaging with health professionals. They described limited choice and influence on the course of their treatment, and low information levels regarding their treatment, which they considered to consist...

  5. Using GRADE methodology for the development of public health guidelines for the prevention and treatment of HIV and other STIs among men who have sex with men and transgender people

    Directory of Open Access Journals (Sweden)

    Akl Elie A

    2012-05-01

    Full Text Available Abstract Background The World Health Organization (WHO Department of HIV/AIDS led the development of public health guidelines for delivering an evidence-based, essential package of interventions for the prevention and treatment of HIV and other sexually transmitted infections (STIs among men who have sex with men (MSM and transgender people in the health sector in low- and middle-income countries. The objective of this paper is to review the methodological challenges faced and solutions applied during the development of the guidelines. Methods The development of the guidelines followed the WHO guideline development process, which utilizes the GRADE approach. We identified, categorized and labeled the challenges identified in the guidelines development process and described the solutions through an interactive process of in-person and electronic communication. Results We describe how we dealt with the following challenges: (1 heterogeneous and complex interventions; (2 paucity of trial data; (3 selecting outcomes of interest; (4 using indirect evidence; (5 integrating values and preferences; (6 considering resource use; (7 addressing social and legal barriers; (8 wording of recommendations; and (9 developing global guidelines. Conclusion We were able to successfully apply the GRADE approach for developing recommendations for public health interventions. Applying the general principles of the approach while carefully considering specific challenges can enhance both the process and the outcome of guideline development.

  6. Club d'orientation

    CERN Multimedia

    Club d'orientation

    2014-01-01

    Courses d’orientation ce printemps Le Club d’orientation du CERN vous invite à venir découvrir la course d’orientation et vous propose, en partenariat avec d’autres clubs de la région, une dizaine de courses populaires. Celles-ci ont lieu les samedis après-midi, elles sont ouvertes à tous, quel que soit le niveau, du débutant au sportif confirmé, en famille ou en individuel, en promenade ou en course. Si vous êtes débutant vous pouvez profiter d’une petite initiation offerte par l’organisateur avant de vous lancer sur un parcours. Divers types de parcours sont à votre choix lors de chaque épreuve: facile court (2-3 km), facile moyen (3-5 km), technique court (3-4 km), technique moyen (4-5 km) et technique long (5-7 km). Les dates à retenir sont les suivantes pour la coupe genevoise de printemps: Samedi 22 mars: Apples (...

  7. Design Methodology - Design Synthesis

    DEFF Research Database (Denmark)

    Andreasen, Mogens Myrup

    2003-01-01

    Design Methodology is part of our practice and our knowledge about designing, and it has been strongly supported by the establishing and work of a design research community. The aim of this article is to broaden the reader¿s view of designing and Design Methodology. This is done by sketching...... the development of Design Methodology through time and sketching some important approaches and methods. The development is mainly forced by changing industrial condition, by the growth of IT support for designing, but also by the growth of insight into designing created by design researchers.......ABSTRACT Design Methodology shall be seen as our understanding of how to design; it is an early (emerging late 60ies) and original articulation of teachable and learnable methodics. The insight is based upon two sources: the nature of the designed artefacts and the nature of human designing. Today...

  8. GPS system simulation methodology

    Science.gov (United States)

    Ewing, Thomas F.

    1993-01-01

    The following topics are presented: background; Global Positioning System (GPS) methodology overview; the graphical user interface (GUI); current models; application to space nuclear power/propulsion; and interfacing requirements. The discussion is presented in vugraph form.

  9. Hazard classification methodology

    International Nuclear Information System (INIS)

    Brereton, S.J.

    1996-01-01

    This document outlines the hazard classification methodology used to determine the hazard classification of the NIF LTAB, OAB, and the support facilities on the basis of radionuclides and chemicals. The hazard classification determines the safety analysis requirements for a facility

  10. Nonlinear Image Denoising Methodologies

    National Research Council Canada - National Science Library

    Yufang, Bao

    2002-01-01

    In this thesis, we propose a theoretical as well as practical framework to combine geometric prior information to a statistical/probabilistic methodology in the investigation of a denoising problem...

  11. Clinical trial methodology

    National Research Council Canada - National Science Library

    Peace, Karl E; Chen, Ding-Geng

    2011-01-01

    "Now viewed as its own scientific discipline, clinical trial methodology encompasses the methods required for the protection of participants in a clinical trial and the methods necessary to provide...

  12. Partitioning an object-oriented terminology schema.

    Science.gov (United States)

    Gu, H; Perl, Y; Halper, M; Geller, J; Kuo, F; Cimino, J J

    2001-07-01

    Controlled medical terminologies are increasingly becoming strategic components of various healthcare enterprises. However, the typical medical terminology can be difficult to exploit due to its extensive size and high density. The schema of a medical terminology offered by an object-oriented representation is a valuable tool in providing an abstract view of the terminology, enhancing comprehensibility and making it more usable. However, schemas themselves can be large and unwieldy. We present a methodology for partitioning a medical terminology schema into manageably sized fragments that promote increased comprehension. Our methodology has a refinement process for the subclass hierarchy of the terminology schema. The methodology is carried out by a medical domain expert in conjunction with a computer. The expert is guided by a set of three modeling rules, which guarantee that the resulting partitioned schema consists of a forest of trees. This makes it easier to understand and consequently use the medical terminology. The application of our methodology to the schema of the Medical Entities Dictionary (MED) is presented.

  13. Identification and Modelling of the In-Plane Reinforcement Orientation Variations in a CFRP Laminate Produced by Manual Lay-Up

    Science.gov (United States)

    Davila, Yves; Crouzeix, Laurent; Douchin, Bernard; Collombet, Francis; Grunevald, Yves-Henri

    2017-08-01

    Reinforcement angle orientation has a significant effect on the mechanical properties of composite materials. This work presents a methodology to introduce variable reinforcement angles into finite element (FE) models of composite structures. The study of reinforcement orientation variations uses meta-models to identify and control a continuous variation across the composite ply. First, the reinforcement angle is measured through image analysis techniques of the composite plies during the lay-up phase. Image analysis results show that variations in the mean ply orientations are between -0.5 and 0.5° with standard deviations ranging between 0.34 and 0.41°. An automatic post-treatment of the images determines the global and local angle variations yielding good agreements visually and numerically between the analysed images and the identified parameters. A composite plate analysed at the end of the cooling phase is presented as a case of study. Here, the variation in residual strains induced by the variability in the reinforcement orientation are up to 28% of the strain field of the homogeneous FE model. The proposed methodology has shown its capabilities to introduce material and geometrical variability into FE analysis of layered composite structures.

  14. Identification and Modelling of the In-Plane Reinforcement Orientation Variations in a CFRP Laminate Produced by Manual Lay-Up

    Science.gov (United States)

    Davila, Yves; Crouzeix, Laurent; Douchin, Bernard; Collombet, Francis; Grunevald, Yves-Henri

    2018-06-01

    Reinforcement angle orientation has a significant effect on the mechanical properties of composite materials. This work presents a methodology to introduce variable reinforcement angles into finite element (FE) models of composite structures. The study of reinforcement orientation variations uses meta-models to identify and control a continuous variation across the composite ply. First, the reinforcement angle is measured through image analysis techniques of the composite plies during the lay-up phase. Image analysis results show that variations in the mean ply orientations are between -0.5 and 0.5° with standard deviations ranging between 0.34 and 0.41°. An automatic post-treatment of the images determines the global and local angle variations yielding good agreements visually and numerically between the analysed images and the identified parameters. A composite plate analysed at the end of the cooling phase is presented as a case of study. Here, the variation in residual strains induced by the variability in the reinforcement orientation are up to 28% of the strain field of the homogeneous FE model. The proposed methodology has shown its capabilities to introduce material and geometrical variability into FE analysis of layered composite structures.

  15. Evaluation of trauma service orientation.

    Science.gov (United States)

    Schott, Eric

    2010-02-01

    Orientation of residents to clinical services may be criticized as cumbersome, dull, and simplytoo much information. With the mandated resident-hour restrictions, the question arose: Do residents perceive the orientation to our trauma service as worthwhile? Residents attend a standardized orientation lecture on the first day of the rotation. Three weeks later, an eight-item, five-point Likert-scale survey is distributed to assess the residents' perceptions of the value of the orientation. Responses to each item were examined. Fifty-four (92%) of the residents completed the questionnaire between September 2005 and August 2006. Most indicated that orientation was helpful (85%), the Trauma Resuscitation DVD was informative (82%), the review of procedures was helpful (82%), and the instructor's knowledge was adequate (94%). Most (92%) disagreed with the statement that orientation should not be offered. Careful attention to orientation content and format is important to the perception that the orientation is worthwhile.

  16. Methodology of sustainability accounting

    Directory of Open Access Journals (Sweden)

    O.H. Sokil

    2017-03-01

    Full Text Available Modern challenges of the theory and methodology of accounting are realized through the formation and implementation of new concepts, the purpose of which is to meet the needs of users in standard and unique information. The development of a methodology for sustainability accounting is a key aspect of the management of an economic entity. The purpose of the article is to form the methodological bases of accounting for sustainable development and determine its goals, objectives, object, subject, methods, functions and key aspects. The author analyzes the theoretical bases of the definition and considers the components of the traditional accounting methodology. Generalized structural diagram of the methodology for accounting for sustainable development is offered in the article. The complex of methods and principles of sustainable development accounting for systematized and non-standard provisions has been systematized. The new system of theoretical and methodological provisions of accounting for sustainable development is justified in the context of determining its purpose, objective, subject, object, methods, functions and key aspects.

  17. Simultaneous optimization of beam orientations and beam weights in conformal radiotherapy

    International Nuclear Information System (INIS)

    Rowbottom, Carl Graham; Khoo, Vincent S.; Webb, Steve

    2001-01-01

    A methodology for the concurrent optimization of beam orientations and beam weights in conformal radiotherapy treatment planning has been developed and tested on a cohort of five patients. The algorithm is based on a beam-weight optimization scheme with a downhill simplex optimization engine. The use of random voxels in the dose calculation provides much of the required speed up in the optimization process, and allows the simultaneous optimization of beam orientations and beam weights in a reasonable time. In the implementation of the beam-weight optimization algorithm just 10% of the original patient voxels are used for the dose calculation and cost function evaluation. A fast simulated annealing algorithm controls the optimization of the beam arrangement. The optimization algorithm was able to produce clinically acceptable plans for the five patients in the cohort study. The algorithm equalized the dose to the optic nerves compared to the standard plans and reduced the mean dose to the brain stem by an average of 4.4% (±1.9, 1 SD), p value=0.007. The dose distribution to the PTV was not compromised by developing beam arrangements via the optimization algorithm. In conclusion, the simultaneous optimization of beam orientations and beam weights has been developed to be routinely used in a realistic time. The results of optimization in a small cohort study show that the optimization can reliably produce clinically acceptable dose distributions and may be able to improve dose distributions compared to those from a human planner

  18. Proposed Framework which Uses Object Oriented Principles in Relational Systems: Structure and Formating (Part 2

    Directory of Open Access Journals (Sweden)

    Catalin STRIMBEI

    2006-01-01

    Full Text Available Our approach tries to overcome the limitations of so called “flat nature” of relational systems, in the actual context of actual relational database theories, database systems technologies and object oriented methodologies by proposing an MDA framework to map an object oriented (UML formalized model to object-relational structures of today’s database systems.

  19. Organization of Individual Work of Students under Competence-Oriented Approach to Education in Higher School

    Science.gov (United States)

    Ualiyeva, Nazym T.; Murzalinova, Alma Z.

    2016-01-01

    The main objective of this research is to identify the essence, content and specifics of organization of individual work of higher school students under competence-oriented approach. The research methodology is related to the choice of competence-oriented approach to ensure transformation of individual work into individual activity in…

  20. Combining goal-oriented and model-driven approaches to solve the Payment Problem Scenario

    NARCIS (Netherlands)

    Asuncion, C.H.; Quartel, Dick; Pokraev, S.; Iacob, Maria Eugenia; van Sinderen, Marten J.

    2010-01-01

    Motivated by the objective to provide an improved participation of business domain experts in the design of service-oriented integration solutions, we extend our previous work on using the COSMO methodology for service mediation by introducing a goal-oriented approach to requirements engineering.

  1. Different Types of Sensation Seeking: A Person-Oriented Approach in Sensation-Seeking Research

    Science.gov (United States)

    Suranyi, Zsuzsanna; Hitchcock, David B.; Hittner, James B.; Vargha, Andras; Urban, Robert

    2013-01-01

    Previous research on sensation seeking (SS) was dominated by a variable-oriented approach indicating that SS level has a linear relation with a host of problem behaviors. Our aim was to provide a person-oriented methodology--a probabilistic clustering--that enables examination of both inter- and intra-individual differences in not only the level,…

  2. Developing Practice Oriented Undergraduate Courses in a Quality Framework. A Case Study: Bachelor of Event Management

    Science.gov (United States)

    Whitelaw, Paul A.; Wrathall, Jeffrey

    2015-01-01

    Purpose: The purpose of this paper is to reflect upon the stakeholder, scholarly, academic and jurisdictional influences on course development for a vocationally oriented bachelor's degree. Design/methodology/approach: This paper takes the form of a case study. Findings: Vocationally oriented bachelor's courses can be developed, especially when…

  3. The effects of market orientation

    OpenAIRE

    Sandvik, Kåre

    1998-01-01

    This research is designed to accomplish three goals. The first goal is to revisit the market orientation construct in order to define the different facets of it. A review of the market orientation literature is made to assess and synthesize the stock of accumulated knowledge regarding the market orientation construct. The second goal of the research is to develop a theory of the effects ofmarket orientation. Using the literature concerning resource-based theory and organization...

  4. Butterfly valve torque prediction methodology

    International Nuclear Information System (INIS)

    Eldiwany, B.H.; Sharma, V.; Kalsi, M.S.; Wolfe, K.

    1994-01-01

    As part of the Motor-Operated Valve (MOV) Performance Prediction Program, the Electric Power Research Institute has sponsored the development of methodologies for predicting thrust and torque requirements of gate, globe, and butterfly MOVs. This paper presents the methodology that will be used by utilities to calculate the dynamic torque requirements for butterfly valves. The total dynamic torque at any disc position is the sum of the hydrodynamic torque, bearing torque (which is induced by the hydrodynamic force), as well as other small torque components (such as packing torque). The hydrodynamic torque on the valve disc, caused by the fluid flow through the valve, depends on the disc angle, flow velocity, upstream flow disturbances, disc shape, and the disc aspect ratio. The butterfly valve model provides sets of nondimensional flow and torque coefficients that can be used to predict flow rate and hydrodynamic torque throughout the disc stroke and to calculate the required actuation torque and the maximum transmitted torque throughout the opening and closing stroke. The scope of the model includes symmetric and nonsymmetric discs of different shapes and aspects ratios in compressible and incompressible fluid applications under both choked and nonchoked flow conditions. The model features were validated against test data from a comprehensive flowloop and in situ test program. These tests were designed to systematically address the effect of the following parameters on the required torque: valve size, disc shapes and disc aspect ratios, upstream elbow orientation and its proximity, and flow conditions. The applicability of the nondimensional coefficients to valves of different sizes was validated by performing tests on 42-in. valve and a precisely scaled 6-in. model. The butterfly valve model torque predictions were found to bound test data from the flow-loop and in situ testing, as shown in the examples provided in this paper

  5. Methodological Approaches to the Prevention Of Schoolgirls’ Deviant Behavior

    Directory of Open Access Journals (Sweden)

    Ivanna Parfanovych

    2017-03-01

    Full Text Available The methodological approaches to the system of girls’ deviant behavior prevention thatact on different levels on prevention are identified: gender, personality oriented, systematic,synergetic, security and safety, interdisciplinary, institutional, which are provided at differentlevels of prevention. Methodological approaches were applied while developing the design,implementing and analyzing of schoolgirls deviant behavior prevention. Such approaches canbe implemented in practice, if the realities of girls’ socialization in various areas and theproblem are treated from the socio-pedagogical point of view.Key words: schoolgirls, deviant behavior, prevention, methodological approaches.

  6. Moral Orientation, Gender, and Salary.

    Science.gov (United States)

    Manning, Roger W.

    A study examined the relationship among gender, moral orientation, and pay. Although the participants were about equal in terms of gender, 48 males and 53 females, males tended to hold higher degrees. The researcher hypothesized that salaries would be differentiated based on gender and moral orientation. Assumptions were that care-oriented males…

  7. Community Orientation and Media Use.

    Science.gov (United States)

    Neuwirth, Kurt; And Others

    1989-01-01

    Examines the relationship among media use, participation in local shopping and leisure activities, and orientation toward the local community. Reexamines Robert Merton's Cosmopolitan scale, finding it to have both localite (exclusively local orientation) and cosmopolite (orientation to events outside the local community) dimensions. (MM)

  8. Understanding voter orientation in the context of political market orientation

    DEFF Research Database (Denmark)

    Ormrod, Robert P.; Henneberg, Stephan C.

    2010-01-01

    This article develops a conceptual framework and measurement model of political market orientation. The relationships between different behavioural aspects of political market orientation and the attitudinal influences of such behaviour are analysed, and the study includes structural equation...... modelling to test several hypotheses. While the results show that political parties focus on several different aspects of market-oriented behaviour, especially using an internal and societal orientation as cultural antecedents, a more surprising result is the inconclusive effect of a voter orientation...... on political market orientation. This lends support to the argument of 'looking beyond the customer' in political marketing research and practice. The article discusses the findings in the context of the existing literature on political marketing and commercial market orientation....

  9. Implementation impacts of PRL methodology

    International Nuclear Information System (INIS)

    Caudill, J.A.; Krupa, J.F.; Meadors, R.E.; Odum, J.V.; Rodrigues, G.C.

    1993-02-01

    This report responds to a DOE-SR request to evaluate the impacts from implementation of the proposed Plutonium Recovery Limit (PRL) methodology. The PRL Methodology is based on cost minimization for decisions to discard or recover plutonium contained in scrap, residues, and other plutonium bearing materials. Implementation of the PRL methodology may result in decisions to declare as waste certain plutonium bearing materials originally considered to be a recoverable plutonium product. Such decisions may have regulatory impacts, because any material declared to be waste would immediately be subject to provisions of the Resource Conservation and Recovery Act (RCRA). The decision to discard these materials will have impacts on waste storage, treatment, and disposal facilities. Current plans for the de-inventory of plutonium processing facilities have identified certain materials as candidates for discard based upon the economic considerations associated with extending the operating schedules for recovery of the contained plutonium versus potential waste disposal costs. This report evaluates the impacts of discarding those materials as proposed by the F Area De-Inventory Plan and compares the De-Inventory Plan assessments with conclusions from application of the PRL. The impact analysis was performed for those materials proposed as potential candidates for discard by the De-Inventory Plan. The De-Inventory Plan identified 433 items, containing approximately 1% of the current SRS Pu-239 inventory, as not appropriate for recovery as the site moves to complete the mission of F-Canyon and FB-Line. The materials were entered into storage awaiting recovery as product under the Department's previous Economic Discard Limit (EDL) methodology which valued plutonium at its incremental cost of production in reactors. An application of Departmental PRLs to the subject 433 items revealed that approximately 40% of them would continue to be potentially recoverable as product plutonium

  10. Sacral orientation and spondylolysis.

    Science.gov (United States)

    Peleg, Smadar; Dar, Gali; Steinberg, Nili; Masharawi, Youssef; Been, Ella; Abbas, Janan; Hershkovitz, Israel

    2009-12-01

    A descriptive study (based on skeletal material) was designed to measure sacral anatomic orientation (SAO) in individuals with and without spondylolysis. To test whether a relationship between SAO and spondylolysis exists. Spondylolysis is a stress fracture in the pars interarticularis (mainly of L5). The natural history of the phenomenon has been debated for years with opinions divided, i.e., is it a developmental condition or a stress fracture phenomenon. There is some evidence to suggest that sacral orientation can be a "key player" in revealing the etiology of spondylolysis. The pelvis was anatomically reconstructed and SAO was measured as the angle created between the intersection of a line running parallel to the superior surface of the sacrum and a line running between the anterior superior iliac spine (ASIS) and the anterior-superior edge of the symphysis pubis (PUBIS).SAO was measured in 99 adult males with spondylolysis and 125 adult males without spondylolysis. The difference between the groups was tested using an unpaired t test. Spondylolysis prevalence is significantly higher in African-Americans compared to European-Americans: 5.4% versus 2.04% in males (P < 0.001) and 2.31% versus 0.4%, P < 0.001 in females. SAO was significantly lower in the spondylolytic group (44.07 degrees +/- 11.46 degrees) compared to the control group (51.07 degrees +/- 8.46 degrees, P < 0.001). A more horizontally oriented sacrum leads to direct impingement on L5 pars interarticularis by both L4 inferior articular facet superiorly and S1 superior articular facet inferiorly. Repetitive stress due to standing (daily activities) or sitting increases the "pincer effect" on this area, and eventually may lead to incomplete synostosis of the neural arch.

  11. Emotion-oriented systems

    CERN Document Server

    Pelachaud, Catherine

    2013-01-01

    The Affective Computing domain, term coined by Rosalind Picard in 1997, gathers several scientific areas such as computer science, cognitive science, psychology, design and art. The humane-machine interaction systems are no longer solely fast and efficient. They aim to offer to users affective experiences: user's affective state is detected and considered within the interaction; the system displays affective state; it can reason about their implication to achieve a task or resolve a problem. In this book, we have chosen to cover various domains of research in emotion-oriented systems. Our aim

  12. Mina Oriental report

    International Nuclear Information System (INIS)

    Cicalese, H.; Mari, C.; Lema, F.; Valverde, C.; Haut, R.

    1986-01-01

    This report refers to the obtained results of those geophysical works practiced during the year 1985 in Mina Oriental region, located in the department of Maldonado. The same ones had like object to supplement geophysical studies previous carried out in the area and to investigate a possible connection mineralized in the geologic context with Mina La Esperanza that , where they arose anomalous indications in geochemical prospecting. They were applied the following methods: Induced Polarization, Magnetometry and Electromagnetism. The conclusions and recommendations arrived express one discontinuity among the referred areas, even subtracting some explanations on the detected lateral anomalies.

  13. Toward methodological emancipation in applied health research.

    Science.gov (United States)

    Thorne, Sally

    2011-04-01

    In this article, I trace the historical groundings of what have become methodological conventions in the use of qualitative approaches to answer questions arising from the applied health disciplines and advocate an alternative logic more strategically grounded in the epistemological orientations of the professional health disciplines. I argue for an increasing emphasis on the modification of conventional qualitative approaches to the particular knowledge demands of the applied practice domain, challenging the merits of what may have become unwarranted attachment to theorizing. Reorienting our methodological toolkits toward the questions arising within an evidence-dominated policy agenda, I encourage my applied health disciplinary colleagues to make themselves useful to that larger project by illuminating that which quantitative research renders invisible, problematizing the assumptions on which it generates conclusions, and filling in the gaps in knowledge needed to make decisions on behalf of people and populations.

  14. Regional Shelter Analysis Methodology

    Energy Technology Data Exchange (ETDEWEB)

    Dillon, Michael B. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dennison, Deborah [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kane, Jave [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Walker, Hoyt [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Miller, Paul [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-08-01

    The fallout from a nuclear explosion has the potential to injure or kill 100,000 or more people through exposure to external gamma (fallout) radiation. Existing buildings can reduce radiation exposure by placing material between fallout particles and exposed people. Lawrence Livermore National Laboratory was tasked with developing an operationally feasible methodology that could improve fallout casualty estimates. The methodology, called a Regional Shelter Analysis, combines the fallout protection that existing buildings provide civilian populations with the distribution of people in various locations. The Regional Shelter Analysis method allows the consideration of (a) multiple building types and locations within buildings, (b) country specific estimates, (c) population posture (e.g., unwarned vs. minimally warned), and (d) the time of day (e.g., night vs. day). The protection estimates can be combined with fallout predictions (or measurements) to (a) provide a more accurate assessment of exposure and injury and (b) evaluate the effectiveness of various casualty mitigation strategies. This report describes the Regional Shelter Analysis methodology, highlights key operational aspects (including demonstrating that the methodology is compatible with current tools), illustrates how to implement the methodology, and provides suggestions for future work.

  15. APPROACH FOR IMPROVING THE INTEGRATED SENSOR ORIENTATION

    Directory of Open Access Journals (Sweden)

    E. Mitishita

    2016-06-01

    Full Text Available The direct determination of exterior orientation parameters (EOP of aerial images via integration of the Inertial Measurement Unit (IMU and GPS is often used in photogrammetric mapping nowadays. The accuracies of the EOP depend on the accurate parameters related to sensors mounting when the job is performed (offsets of the IMU relative to the projection centre and the angles of boresigth misalignment between the IMU and the photogrammetric coordinate system. In principle, when the EOP values do not achieve the required accuracies for the photogrammetric application, the approach, known as Integrated Sensor Orientation (ISO, is used to refine the direct EOP. ISO approach requires accurate Interior Orientation Parameters (IOP and standard deviation of the EOP under flight condition. This paper investigates the feasibility of use the in situ camera calibration to obtain these requirements. The camera calibration uses a small sub block of images, extracted from the entire block. A digital Vexcel UltraCam XP camera connected to APPLANIX POS AVTM system was used to get two small blocks of images that were use in this study. The blocks have different flight heights and opposite flight directions. The proposed methodology improved significantly the vertical and horizontal accuracies of the 3D point intersection. Using a minimum set of control points, the horizontal and vertical accuracies achieved nearly one image pixel of resolution on the ground (GSD. The experimental results are shown and discussed.

  16. ORIENTATION TOWARD CUSTOMER FOR PUBLIC FOOD SERVICE

    Directory of Open Access Journals (Sweden)

    LIVIU ILIE FACALEATA

    2015-10-01

    Full Text Available In the context of accelerated economic globalization and hyper global competition, companies must have a high degree of orientation in the market, to know and respond quickly to volatile markets. In this context, the public food field is one marked by significant changes having regard to needs and consumer behavior. Public food services are designed to meet first the basic needs which causes certain private actions and a particular mechanism for the training of behavior with significant impact on the way in which the companies of public food should develop services and certain ambient which to contribute to the proper customer service. Moreover, these companies have aspecial relationship with customers, having regard to the direct interaction between supplier and customer. This present project aimsto identify good practice in the field of public food service regarding the implementation of the philosophy orientation on the marketplace. To achieve this goal has been used as methodology the analysis of the primary results from previous research in the fields of both market direction, as well as in the hospitality areas, analysis which has had as main objective a stock-taking of the models developed for the hospitality industry and compiling influence factors with impact on the "good service" of the client, but also integration of orientation principles toward market within the framework of these models.

  17. Visual cells remember earlier applied target: plasticity of orientation selectivity.

    Directory of Open Access Journals (Sweden)

    Narcis Ghisovan

    Full Text Available BACKGROUND: A canonical proposition states that, in mature brain, neurons responsive to sensory stimuli are tuned to specific properties installed shortly after birth. It is amply demonstrated that that neurons in adult visual cortex of cats are orientation-selective that is they respond with the highest firing rates to preferred oriented stimuli. METHODOLOGY/PRINCIPAL FINDINGS: In anesthetized cats, prepared in a conventional fashion for single cell recordings, the present investigation shows that presenting a stimulus uninterruptedly at a non-preferred orientation for twelve minutes induces changes in orientation preference. Across all conditions orientation tuning curves were investigated using a trial by trial method. Contrary to what has been previously reported with shorter adaptation duration, twelve minutes of adaptation induces mostly attractive shifts, i.e. toward the adapter. After a recovery period allowing neurons to restore their original orientation tuning curves, we carried out a second adaptation which produced three major results: (1 more frequent attractive shifts, (2 an increase of their magnitude, and (3 an additional enhancement of responses at the new or acquired preferred orientation. Additionally, we also show that the direction of shifts depends on the duration of the adaptation: shorter adaptation in most cases produces repulsive shifts, whereas adaptation exceeding nine minutes results in attractive shifts, in the same unit. Consequently, shifts in preferred orientation depend on the duration of adaptation. CONCLUSION/SIGNIFICANCE: The supplementary response improvements indicate that neurons in area 17 keep a memory trace of the previous stimulus properties, thereby upgrading cellular performance. It also highlights the dynamic nature of basic neuronal properties in adult cortex since repeated adaptations modified both the orientation tuning selectivity and the response strength to the preferred orientation. These

  18. The policy trail methodology

    DEFF Research Database (Denmark)

    Holford, John; Larson, Anne; Melo, Susana

    of ‘policy trail’, arguing that it can overcome ‘methodological nationalism’ and link structure and agency in research on the ‘European educational space’. The ‘trail’ metaphor, she suggests, captures the intentionality and the erratic character of policy. The trail connects sites and brings about change......, but – although policy may be intended to be linear, with specific outcomes – policy often has to bend, and sometimes meets insurmountable obstacles. This symposium outlines and develops the methodology, but also reports on research undertaken within a major FP7 project (LLLIght’in’Europe, 2012-15) which made use......In recent years, the “policy trail” has been proposed as a methodology appropriate to the shifting and fluid governance of lifelong learning in the late modern world (Holford et al. 2013, Holford et al. 2013, Cort 2014). The contemporary environment is marked by multi-level governance (global...

  19. Club d'orientation

    CERN Document Server

    Le Club d’Orientation du CERN

    2011-01-01

      Course d’orientation : Coupe Genevoise de printemps 2011 Nouvelle saison – nouveau programme Le Club d’Orientation du CERN, en partenariat avec d’autres clubs de la région, vous propose une dizaine de courses pour la coupe de printemps. Elles se dérouleront des deux cotés de la frontière franco-suisse, à savoir : Samedi 19 mars: Vidy/Dorigny (Vd) - Score Samedi 26 mars: Attalens (Vd) Samedi 2 avril: Vulbens (74) Samedi 9 avril: Challex (74) Samedi 16 avril: Vernand-Dessus (Vd) Samedi 7 mai: Trelex (Vd) Samedi 14 mai: Chancy/Valleiry (Ge/74) Samedi 21 mai: Prémanon (39) Samedi 28 mai : Semnoz (74) Samedi 18 juin: La Faucille (01) – Finale Ces courses populaires ont lieu le samedi après-midi, elles sont ouvertes à tous, quel que soit le niveau, du débutant au sportif confirmé...

  20. Milestones Universidad de Oriente

    Directory of Open Access Journals (Sweden)

    Julio A. Villalón-Infante

    2016-09-01

    Full Text Available On October 10, 1947, the University of Oriente is founded with the presence of local authorities and the historic Bell of the Damajagua. Since then it has generated outstanding events that have drawn guidelines in its history. These landmarks have taken place in different spheres of social, political and economic life. We have found that most workers and students from the University know less than fifty percent of such events, and we assume that the population outside the walls must have a greater ignorance. The present paper aims to spread these crucial events because knowing them will help appreciate better the real prestige of this house of higher learning through its rich  history, which will result in feelings of admiration and respect for this university. Thus, it is necessary to make a wider propagation through the press, radio and television programs and digital media such as Multimedia, Web Pages and the Internet.The theme landmark at the Universidad de Oriente of the subject Historical and Contemporary Debates implemented in the disciplines of all careers at this university gives freshmen the opportunity to investigate and learn about these remarkable  facts with some impact outside our national territory.

  1. Club d'orientation

    CERN Multimedia

    Le Club d’Orientation du CERN

    2011-01-01

    La première course d’orientation comptant pour la Coupe Genevoise de printemps a eu lieu près de Cossonay samedi 19 mars ; une bonne soixantaine de coureurs avaient fait le déplacement. Les vainqueurs sont : technique long, Domenico Lepori (Care Vevey) s’imposant d’une minute devant Yannick Gagneret (O’Jura) ; technique moyen, Jean-Rodolphe Knuchel (CO Lausanne-Jorat) devant Cédric Wehrle (CO CERN) ; technique court, Marie Droz (ANCO) ; facile moyen, Elia Martarelli devant Konstantinos Haider (CO CERN); facile court, Sarah Stuber (CO Lausanne-Jorat). Prochain rendez-vous à noter : samedi 26 mars dans la forêt d’Attalens (Canton de Vaud), parking au terrain de foot. Les inscriptions et départs de la course populaire se feront entre 13h et 15h. Pour ceux qui ne connaissent pas l’orientation, c’est l&am...

  2. Course d'Orientation

    CERN Multimedia

    Course d'Orientation

    2012-01-01

      Coupe de printemps La deuxième étape de la coupe de printemps organisée par le club d’orientation du CERN s’est déroulée le samedi 21 avril dans la forêt de Pougny-Challex. étant donné le temps très humide qui domine depuis début avril, les coureurs ne pouvaient trouver qu’un terrain gras et trempé, mais cela fait partie des défis de la course d’orientation. Le parcours technique long a été remporté par Yvan Balliot, CO Annecy en 51:18 devant Jean-Charles Baritaux en 56:21 et Bruno Barge, CO CERN en 59:39. La prochaine CO populaire se courra à Vulbens le samedi 28 avril. Les inscriptions et les départs se feront entre 13h et 15h. A noter les courses en mai : • Samedi 5 mai : Trelex • Samedi 12 mai : Chancy / Valleiry • Samedi 19 mai : Lausan...

  3. Fuel cycle oriented approach

    International Nuclear Information System (INIS)

    Petit, A.

    1987-01-01

    The term fuel cycle oriented approach is currently used to designate two quite different things: the attempt to consider all or part of a national fuel cycle as one material balance area (MBA) or to consider individual MBAs existing in a state while designing a unique safeguards approach for each and applying the principle of nondiscrimination to fuel cycles as a whole, rather than to individual facilities. The merits of such an approach are acceptability by the industry and comparison with the contemplated establishment of long-term criteria. The following points concern the acceptability by the industry: (1) The main interest of the industry is to keep an open international market and therefore, to have effective and efficient safeguards. (2) The main concerns of the industry regarding international safeguards are economic burden, intrusiveness, and discrimination. Answers to these legitimate concerns, which retain the benefits of a fuel cycle oriented approach, are needed. More specifically, the problem of reimbursing the operator the costs that he has incurred for the safeguards must be considered

  4. Quality improvement of oriental melon and watermelon using bioceramics

    International Nuclear Information System (INIS)

    Song, H.K.; Lee, K.J.; Ryou, Y.S.

    1996-01-01

    Oriental melon and watermelon plants were cultivated in the soil treated with bioceramics in a greenhouse during summer season from June 1st to August 20th, 1995. Two application methods were employed, one was a mixed treatment of soil and bioceramics, and the other was a spray treatment of bioceramic solution on the stems and leaves. And two types of bioceramics were also stopped by five levels. In order to analyze the bioceramic effect on oriental melon and watermelon, the growth rate of stems, leaves and fruits were measured in the greenhouse. After harvest, the sweetness of fruits was measured and the freshness of fruits based on the storage period was tested by human taste and smell sense. The results are summarized as follows. 1. The growth rates of stems, leaves and fruits of oriental melon and watermelon were the largest in the bioceramic treatment of No. 3. 2. The density of oriental melon and watermelon was the largest in the bioceramic treatment of No. 3 and No. 2 respectively. 3. The Brix number of watermelon was 10.6 in non-bioceramic treatment and 11.5 in the bioceramic treatment of No. 2, and that of oriental melon was 8.6 in non-bioceramic treatment and 12.3 in the bioceramic treatment of No. 2. 4. The storage duration of watermelon treated with bioceramics was about 50 days in the condition of the ambient temperature of 25∼30°C. (author)

  5. A methodology for performing computer security reviews

    International Nuclear Information System (INIS)

    Hunteman, W.J.

    1991-01-01

    DOE Order 5637.1, ''Classified Computer Security,'' requires regular reviews of the computer security activities for an ADP system and for a site. Based on experiences gained in the Los Alamos computer security program through interactions with DOE facilities, we have developed a methodology to aid a site or security officer in performing a comprehensive computer security review. The methodology is designed to aid a reviewer in defining goals of the review (e.g., preparation for inspection), determining security requirements based on DOE policies, determining threats/vulnerabilities based on DOE and local threat guidance, and identifying critical system components to be reviewed. Application of the methodology will result in review procedures and checklists oriented to the review goals, the target system, and DOE policy requirements. The review methodology can be used to prepare for an audit or inspection and as a periodic self-check tool to determine the status of the computer security program for a site or specific ADP system. 1 tab

  6. A methodology for performing computer security reviews

    International Nuclear Information System (INIS)

    Hunteman, W.J.

    1991-01-01

    This paper reports on DIE Order 5637.1, Classified Computer Security, which requires regular reviews of the computer security activities for an ADP system and for a site. Based on experiences gained in the Los Alamos computer security program through interactions with DOE facilities, the authors have developed a methodology to aid a site or security officer in performing a comprehensive computer security review. The methodology is designed to aid a reviewer in defining goals of the review (e.g., preparation for inspection), determining security requirements based on DOE policies, determining threats/vulnerabilities based on DOE and local threat guidance, and identifying critical system components to be reviewed. Application of the methodology will result in review procedures and checklists oriented to the review goals, the target system, and DOE policy requirements. The review methodology can be used to prepare for an audit or inspection and as a periodic self-check tool to determine the status of the computer security program for a site or specific ADP system

  7. Examining emotional expressions in discourse: methodological considerations

    Science.gov (United States)

    Hufnagel, Elizabeth; Kelly, Gregory J.

    2017-10-01

    This methodological paper presents an approach for examining emotional expressions through discourse analysis and ethnographic methods. Drawing on trends in the current literature in science education, we briefly explain the importance of emotions in science education and examine the current research methodologies used in interactional emotion studies. We put forth and substantiate a methodological approach that attends to the interactional, contextual, intertextual, and consequential aspects of emotional expressions. By examining emotional expressions in the discourse in which they are constructed, emotional expressions are identified through semantics, contextualization, and linguistic features. These features make salient four dimensions of emotional expressions: aboutness, frequency, type, and ownership. Drawing on data from a large empirical study of pre-service elementary teachers' emotional expressions about climate change in a science course, we provide illustrative examples to describe what counts as emotional expressions in situ. In doing so we explain how our approach makes salient the nuanced nature of such expressions as well as the broader discourse in which they are constructed and the implications for researching emotional expressions in science education discourse. We suggest reasons why this discourse orientated research methodology can contribute to the interactional study of emotions in science education contexts.

  8. Changing methodologies in TESOL

    CERN Document Server

    Spiro, Jane

    2013-01-01

    Covering core topics from vocabulary and grammar to teaching, writing speaking and listening, this textbook shows you how to link research to practice in TESOL methodology. It emphasises how current understandings have impacted on the language classroom worldwide and investigates the meaning of 'methods' and 'methodology' and the importance of these for the teacher: as well as the underlying assumptions and beliefs teachers bring to bear in their practice. By introducing you to language teaching approaches, you will explore the way these are influenced by developments in our understanding of l

  9. Creativity in phenomenological methodology

    DEFF Research Database (Denmark)

    Dreyer, Pia; Martinsen, Bente; Norlyk, Annelise

    2014-01-01

    on the methodologies of van Manen, Dahlberg, Lindseth & Norberg, the aim of this paper is to argue that the increased focus on creativity and arts in research methodology is valuable to gain a deeper insight into lived experiences. We illustrate this point through examples from empirical nursing studies, and discuss......Nursing research is often concerned with lived experiences in human life using phenomenological and hermeneutic approaches. These empirical studies may use different creative expressions and art-forms to describe and enhance an embodied and personalised understanding of lived experiences. Drawing...... may support a respectful renewal of phenomenological research traditions in nursing research....

  10. Sexual orientation and labor market outcomes

    OpenAIRE

    Drydakis, Nick

    2014-01-01

    Studies from countries with laws against discrimination on the basis of sexual orientation suggest that gay and lesbian employees report more incidents of harassment and are more likely to report experiencing unfair treatment in the labor market than are heterosexual employees. Gay men are found to earn less than comparably skilled and experienced heterosexual men. For lesbians, the patterns are ambiguous: in some countries they have been found to earn less than their heterosexual counterpart...

  11. An examination of firms’ strategic orientations, innovativeness and performance with large Korean companies

    Directory of Open Access Journals (Sweden)

    Sohyoun Synthia Shin

    2017-01-01

    Full Text Available Purpose - This paper aims to provide an examination of firms’ strategic orientations, innovativeness and performance with large Korean companies. Design/methodology/approach - The authors investigated the impacts of firms’ major key strategic orientations (customer orientation [CO], competitor orientation [PO], technology orientation [TO] and internal/cost orientation [IO] on firm innovativeness (INNO and performance outcomes with large Korean companies. Findings - The results of the analysis showed that CO, PO and TO positively influence the innovativeness, which contributes to firm performance. Originality/value - The authors provide some managerial implications on the multiple roles of strategic orientations on firm INNO and performances, along with limitations of this study and future research directions.

  12. Patient-centered care requires a patient-oriented workflow model.

    Science.gov (United States)

    Ozkaynak, Mustafa; Brennan, Patricia Flatley; Hanauer, David A; Johnson, Sharon; Aarts, Jos; Zheng, Kai; Haque, Saira N

    2013-06-01

    Effective design of health information technology (HIT) for patient-centered care requires consideration of workflow from the patient's perspective, termed 'patient-oriented workflow.' This approach organizes the building blocks of work around the patients who are moving through the care system. Patient-oriented workflow complements the more familiar clinician-oriented workflow approaches, and offers several advantages, including the ability to capture simultaneous, cooperative work, which is essential in care delivery. Patient-oriented workflow models can also provide an understanding of healthcare work taking place in various formal and informal health settings in an integrated manner. We present two cases demonstrating the potential value of patient-oriented workflow models. Significant theoretical, methodological, and practical challenges must be met to ensure adoption of patient-oriented workflow models. Patient-oriented workflow models define meaningful system boundaries and can lead to HIT implementations that are more consistent with cooperative work and its emergent features.

  13. Object oriented development of engineering software using CLIPS

    Science.gov (United States)

    Yoon, C. John

    1991-01-01

    Engineering applications involve numeric complexity and manipulations of a large amount of data. Traditionally, numeric computation has been the concern in developing an engineering software. As engineering application software became larger and more complex, management of resources such as data, rather than the numeric complexity, has become the major software design problem. Object oriented design and implementation methodologies can improve the reliability, flexibility, and maintainability of the resulting software; however, some tasks are better solved with the traditional procedural paradigm. The C Language Integrated Production System (CLIPS), with deffunction and defgeneric constructs, supports the procedural paradigm. The natural blending of object oriented and procedural paradigms has been cited as the reason for the popularity of the C++ language. The CLIPS Object Oriented Language's (COOL) object oriented features are more versatile than C++'s. A software design methodology based on object oriented and procedural approaches appropriate for engineering software, and to be implemented in CLIPS was outlined. A method for sensor placement for Space Station Freedom is being implemented in COOL as a sample problem.

  14. Computer Network Operations Methodology

    Science.gov (United States)

    2004-03-01

    means of their computer information systems. Disrupt - This type of attack focuses on disrupting as “attackers might surreptitiously reprogram enemy...by reprogramming the computers that control distribution within the power grid. A disruption attack introduces disorder and inhibits the effective...between commanders. The use of methodologies is widespread and done subconsciously to assist individuals in decision making. The processes that

  15. SCI Hazard Report Methodology

    Science.gov (United States)

    Mitchell, Michael S.

    2010-01-01

    This slide presentation reviews the methodology in creating a Source Control Item (SCI) Hazard Report (HR). The SCI HR provides a system safety risk assessment for the following Ares I Upper Stage Production Contract (USPC) components (1) Pyro Separation Systems (2) Main Propulsion System (3) Reaction and Roll Control Systems (4) Thrust Vector Control System and (5) Ullage Settling Motor System components.

  16. Complicating Methodological Transparency

    Science.gov (United States)

    Bridges-Rhoads, Sarah; Van Cleave, Jessica; Hughes, Hilary E.

    2016-01-01

    A historical indicator of the quality, validity, and rigor of qualitative research has been the documentation and disclosure of the behind-the-scenes work of the researcher. In this paper, we use what we call "methodological data" as a tool to complicate the possibility and desirability of such transparency. Specifically, we draw on our…

  17. Methodological Advances in Dea

    NARCIS (Netherlands)

    L. Cherchye (Laurens); G.T. Post (Thierry)

    2001-01-01

    textabstractWe survey the methodological advances in DEA over the last 25 years and discuss the necessary conditions for a sound empirical application. We hope this survey will contribute to the further dissemination of DEA, the knowledge of its relative strengths and weaknesses, and the tools

  18. NUSAM Methodology for Assessment.

    Energy Technology Data Exchange (ETDEWEB)

    Leach, Janice [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Snell, Mark K. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-07-01

    This document provides a methodology for the performance-based assessment of security systems designed for the protection of nuclear and radiological materials and the processes that produce and/or involve them. It is intended for use with both relatively simple installations and with highly regulated complex sites with demanding security requirements.

  19. MIRD methodology. Part 1

    International Nuclear Information System (INIS)

    Rojo, Ana M.

    2004-01-01

    This lecture develops the MIRD (Medical Internal Radiation Dose) methodology for the evaluation of the internal dose due to the administration of radiopharmaceuticals. In this first part, the basic concepts and the main equations are presented. The ICRP Dosimetric System is also explained. (author)

  20. Response Surface Methodology

    NARCIS (Netherlands)

    Kleijnen, Jack P.C.

    2014-01-01

    Abstract: This chapter first summarizes Response Surface Methodology (RSM), which started with Box and Wilson’s article in 1951 on RSM for real, non-simulated systems. RSM is a stepwise heuristic that uses first-order polynomials to approximate the response surface locally. An estimated polynomial

  1. MIRD methodology. Part 2

    International Nuclear Information System (INIS)

    Gomez Parada, Ines

    2004-01-01

    This paper develops the MIRD (Medical Internal Radiation Dose) methodology for the evaluation of the internal dose due to the administration of radiopharmaceuticals. In this second part, different methods for the calculation of the accumulated activity are presented, together with the effective half life definition. Different forms of Retention Activity curves are also shown. (author)

  2. Applications of the rotating orientation XRD method to oriented materials

    International Nuclear Information System (INIS)

    Guo Zhenqi; Li Fei; Jin Li; Bai Yu

    2009-01-01

    The rotating orientation x-ray diffraction (RO-XRD) method, based on conventional XRD instruments by a modification of the sample stage, was introduced to investigate the orientation-related issues of such materials. In this paper, we show its applications including the determination of single crystal orientation, assistance in crystal cutting and evaluation of crystal quality. The interpretation of scanning patterns by RO-XRD on polycrystals with large grains, bulk material with several grains and oriented thin film is also presented. These results will hopefully expand the applications of the RO-XRD method and also benefit the conventional XRD techniques. (fast track communication)

  3. El oriente de Chillida

    Directory of Open Access Journals (Sweden)

    Paloma Galante Rodero

    2011-01-01

    Full Text Available Todo el arte es influyente porque todo arte nace del hombre. Esta pequeña reflexión quiere resaltar cómo el arte y el pensamiento oriental han sido más influyentes, no sólo en el ámbito estético, sino en la concepción espacial y del propio hecho creador, en el arte occidental de lo que a primera vista podemos apreciar. En el caso de Chillida es una influencia no intencionada, muy sutil y analizada desde dos perspectivas, la primera, a partir de sus contactos directos con Japón como Homenaje a Hokusai, exposiciones realizadas y premios concedidos en el país nipón y por otro lado, los contactos indirectos con Oriente como su biblioteca personal, sus colaboraciones editoriales con Heidegger y Valente y su encuentro con Mark Tobey en la Bienal de Venecia de 1958.All art is influential because all art is born of man. This short reflection wants to highlight how eastern art and Eastern thought have been most influential, not only in the aesthetic realm, in spatial conception and creative act, in Western art more than at first glance we can see. In the case of Chillida’s unintentional influence, very subtle and analyzed from two perspectives, first from direct contacts with Japan as Tribute to Hokusai, exhibitions and prizes awarded in the japanese country, and on the other hand, indirect contacts with the East as his personal library, his collaborations with Heidegger and Valente and his encounter with Mark Tobey at the Venice Biennale of 1958.

  4. Impact Orientation in Austria

    Directory of Open Access Journals (Sweden)

    Benedikt SPEER

    2015-12-01

    Full Text Available The implementation of impact orientation within the public sector constitutes an en-tirely new approach of governance. Until recently – and in many cases still so – public administration was primarily input-oriented, which means focusing on the resources (financial, personnel etc. needed to fulfil existing public tasks instead of focusing on the results and final effects which are intended to be reached ultimately by these often long ago defined assignments. As experience shows, the pressing challenge of increasing steadily the effectiveness and efficiency within public administration cannot be reached by such a one-sided and consequently limited approach. Thus, a wider and more comprehensive concept is necessary to optimize the public sector in all its dimensions. As a result of prevalent budget crises, increasing pressure of stakeholders towards public administration and generally less room for manoeuver due to a growing regulatory burden, new/adapted and more flexible ways of thinking and acting within the public sector are required. Hence, modern concepts of steering and control – not only in Europe but in a larger number of OECD countries – now tend to give more importance to the targets and effects of public administration and its activities within the societal context. This rather new concept – the so called “impact orientation” which has been introduced in Austria as core element of the Federal Budget Law Reform 2009/2013 – requires a fundamental alignment of governmental actions and a new focus on the outputs and even on the outcomes of political and administrative strategies. The results until now have been primarily “outwardly-oriented” reform concepts concentrating on the external societal effects of politico-administrative actions. However, recent research results show for Austria, that this external dimension has to be linked more closely with internal reform efforts and internal impact targets in order to

  5. Methodology for comprehensive patient, worker and public radiation protection considerations while introducing new medical procedures

    International Nuclear Information System (INIS)

    Neeman, E.; Keren, M.

    2001-01-01

    Patient protection is a major consideration while introducing new medical procedure. But protection of the workers and the public should be considered too. A methodology of combining non-patient radiation protection considerations with the introduction of new medical procedures is described. The new medical procedure was the Intracoronary Gamma Irradiation for the Prevention of Restenosis by using Iridium 192 gamma radiation sources. The usual authors' responsibility is the licensing of the use of radioactive materials while keeping public protection. According to this responsibility, the methodology's original orientation is public protection. As a result of coordination between several competent authorities, managed by the authors, the methodology was adopted for patient and worker protection too. Applicants, actually possible users (hospitals) of the new procedure, were obliged to plan medical procedures and working area according to dose limits and constrains as recommended by the International Atomic Energy Agency and local competent authorities. Exposure calculations had to consider the usual parameters as sources types and activity, dose rate and dose levels, duration and number of treatments. Special attention was given to the presence workers and public by chance presence in or near treatment area. A usual condition to give a license was the installation of continuous (during treatment) radiation monitoring systems. But a special attention was given to physical barriers and procedures in order to stop unauthorized personal to arrive near to working area. Satisfactory staff training for normal operation and emergency situations are essential, including appropriate safety procedures and the presence of safety assistance team while executing treatment. (author)

  6. Oriented Poly(dialkylstannane)s

    DEFF Research Database (Denmark)

    Choffat, Fabien; Fornera, Sara; Smith, Paul

    2008-01-01

    The inorganic (or 'organometallic') polymers poly(dibutylstannane), poly(dioctylstannane), and poly(didodecylstannane) have been oriented by shear forces, the tensile drawing of blends with polyethylene, and deposition from solution onto glass slides coated with all oriented, friction-deposited p......The inorganic (or 'organometallic') polymers poly(dibutylstannane), poly(dioctylstannane), and poly(didodecylstannane) have been oriented by shear forces, the tensile drawing of blends with polyethylene, and deposition from solution onto glass slides coated with all oriented, friction......-deposited poly(tetrafluoroethylene) (PTFE) layer. Orientation of the polystannanes has been examined by polarization microscopy, UV-vis spectroscopy with polarized light, and X-ray diffraction and their direction is found to depend on the length of the alkyl side groups and the method of orientation. Remarkably...

  7. Problem-solving in organizations : A methodological handbook for business students

    NARCIS (Netherlands)

    Van Aken, Joan Ernst; Berends, Hans; van der Bij, Hans

    2007-01-01

    This concise introduction to the methodology of Business Problem Solving (BPS) is an indispensable guide to the design and execution of practical projects in real organizational settings. The methodology is both result-oriented and theory-based, encouraging students to use the knowledge gained on

  8. Critical Race Design: An Emerging Methodological Approach to Anti-Racist Design and Implementation Research

    Science.gov (United States)

    Khalil, Deena; Kier, Meredith

    2017-01-01

    This article is about introducing Critical Race Design (CRD), a research methodology that centers race and equity at the nucleus of educational opportunities by design. First, the authors define design-based implementation research (DBIR; Penuel, Fishman, Cheng, & Sabelli, 2011) as an equity-oriented education research methodology where…

  9. Problem-solving in organizations : a methodological handbook for business students

    NARCIS (Netherlands)

    Aken, van J.E.; Berends, J.J.; Bij, van der J.D.

    2007-01-01

    This concise introduction to the methodology of Business Problem Solving (BPS) is an indispensable guide to the design and execution of practical projects in real organizational settings. The methodology is both result-oriented and theory-based, encouraging students to use the knowledge gained on

  10. The theory of experience orientation

    DEFF Research Database (Denmark)

    Jensen, Jesper Legaard

    2012-01-01

    This paper describes the theory of experience orientation, which builds on the division of experiences in two categories: Goal-oriented and Omni-oriented. The theory comes from preliminary studies of userexperiences in a work-context, where I have found this distinction to be beneficial....... In this paper I explain the theory behind it and the practical application of such a distinction when designing for an experience....

  11. Methodological issues in lipid bilayer simulations

    NARCIS (Netherlands)

    Anezo, C; de Vries, AH; Holtje, HD; Tieleman, DP; Marrink, SJ

    2003-01-01

    Methodological issues in molecular dynamics (MD) simulations, such as the treatment of long-range electrostatic interactions or the type of pressure coupling, have important consequences for the equilibrium properties observed. We report a series of long (up to 150 ns) MD simulations of

  12. Report of the Orientation Workshop

    DEFF Research Database (Denmark)

    Nunez, Heilyn Camacho; Buus, Lillian; Ogange, Betty

    2014-01-01

    This Orientation Workshops is part of MAAGART project. The workshop is divided in three parts: 1) pre-Orientation Workshop stage, 2) Face-to-Face stage and 3) post-Orientation stage. Pre and post stages will be developed online. All the activities will take place in a virtual learning environment...... created for this purpose. Participants will receive all the information about how to access the virtual learning environment (Moodle) prior to the pre-orientation workshop. In this report we cover only the two first stages. Jørgen Bang, as a part of the Community of Practice activity, will be facilitating...

  13. Orientation decoding: Sense in spirals?

    Science.gov (United States)

    Clifford, Colin W G; Mannion, Damien J

    2015-04-15

    The orientation of a visual stimulus can be successfully decoded from the multivariate pattern of fMRI activity in human visual cortex. Whether this capacity requires coarse-scale orientation biases is controversial. We and others have advocated the use of spiral stimuli to eliminate a potential coarse-scale bias-the radial bias toward local orientations that are collinear with the centre of gaze-and hence narrow down the potential coarse-scale biases that could contribute to orientation decoding. The usefulness of this strategy is challenged by the computational simulations of Carlson (2014), who reported the ability to successfully decode spirals of opposite sense (opening clockwise or counter-clockwise) from the pooled output of purportedly unbiased orientation filters. Here, we elaborate the mathematical relationship between spirals of opposite sense to confirm that they cannot be discriminated on the basis of the pooled output of unbiased or radially biased orientation filters. We then demonstrate that Carlson's (2014) reported decoding ability is consistent with the presence of inadvertent biases in the set of orientation filters; biases introduced by their digital implementation and unrelated to the brain's processing of orientation. These analyses demonstrate that spirals must be processed with an orientation bias other than the radial bias for successful decoding of spiral sense. Copyright © 2014 Elsevier Inc. All rights reserved.

  14. Subcortical orientation biases explain orientation selectivity of visual cortical cells.

    Science.gov (United States)

    Vidyasagar, Trichur R; Jayakumar, Jaikishan; Lloyd, Errol; Levichkina, Ekaterina V

    2015-04-01

    The primary visual cortex of carnivores and primates shows an orderly progression of domains of neurons that are selective to a particular orientation of visual stimuli such as bars and gratings. We recorded from single-thalamic afferent fibers that terminate in these domains to address the issue whether the orientation sensitivity of these fibers could form the basis of the remarkable orientation selectivity exhibited by most cortical cells. We first performed optical imaging of intrinsic signals to obtain a map of orientation domains on the dorsal aspect of the anaesthetized cat's area 17. After confirming using electrophysiological recordings the orientation preferences of single neurons within one or two domains in each animal, we pharmacologically silenced the cortex to leave only the afferent terminals active. The inactivation of cortical neurons was achieved by the superfusion of either kainic acid or muscimol. Responses of single geniculate afferents were then recorded by the use of high impedance electrodes. We found that the orientation preferences of the afferents matched closely with those of the cells in the orientation domains that they terminated in (Pearson's r = 0.633, n = 22, P = 0.002). This suggests a possible subcortical origin for cortical orientation selectivity. © 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

  15. Transparent Guideline Methodology Needed

    DEFF Research Database (Denmark)

    Lidal, Ingeborg; Norén, Camilla; Mäkelä, Marjukka

    2013-01-01

    As part of learning at the Nordic Workshop of Evidence-based Medicine, we have read with interest the practice guidelines for central venous access, published in your Journal in 2012.1 We appraised the quality of this guideline using the checklist developed by The Evidence-Based Medicine Working ...... are based on best currently available evidence. Our concerns are in two main categories: the rigor of development, including methodology of searching, evaluating, and combining the evidence; and editorial independence, including funding and possible conflicts of interest....... Group.2 Similar criteria for guideline quality have been suggested elsewhere.3 Our conclusion was that this much needed guideline is currently unclear about several aspects of the methodology used in developing the recommendations. This means potential users cannot be certain that the recommendations...

  16. Web survey methodology

    CERN Document Server

    Callegaro, Mario; Vehovar, Asja

    2015-01-01

    Web Survey Methodology guides the reader through the past fifteen years of research in web survey methodology. It both provides practical guidance on the latest techniques for collecting valid and reliable data and offers a comprehensive overview of research issues. Core topics from preparation to questionnaire design, recruitment testing to analysis and survey software are all covered in a systematic and insightful way. The reader will be exposed to key concepts and key findings in the literature, covering measurement, non-response, adjustments, paradata, and cost issues. The book also discusses the hottest research topics in survey research today, such as internet panels, virtual interviewing, mobile surveys and the integration with passive measurements, e-social sciences, mixed modes and business intelligence. The book is intended for students, practitioners, and researchers in fields such as survey and market research, psychological research, official statistics and customer satisfaction research.

  17. Everyday-Oriented Innovation

    DEFF Research Database (Denmark)

    Munnecke, Max

    The exploration of radical innovation has long been regarded as fundamental to business growth. In the 21st century, modern organisations increasingly seek to combine business innovation with the broader goal to confront social and environmental challenges. Vision projects are related phenomena...... which explore and map radical innovation opportunities within everyday activities. The aim of a vision project is to produce an innovation map that can empower an organisation to navigate between potential innovation opportunities and pro‐actively confront modern challenges for the benefit of people......, business, and society. The study addresses the concern that vision projects do not produce sufficient navigational innovation maps, and seeks to improve their quality by modelling a new methodological framework. The study was conducted as a series of four research cycles which modelled and experimented...

  18. Steganography: LSB Methodology

    Science.gov (United States)

    2012-08-02

    of LSB steganography in grayscale and color images . In J. Dittmann, K. Nahrstedt, and P. Wohlmacher, editors, Proceedings of the ACM, Special...Fridrich, M. Gojan and R. Du paper titled “Reliable detection of LSB steganography in grayscale and color images ”. From a general perspective Figure 2...REPORT Steganography : LSB Methodology (Progress Report) 14. ABSTRACT 16. SECURITY CLASSIFICATION OF: In computer science, steganography is the science

  19. Soil Radiological Characterisation Methodology

    International Nuclear Information System (INIS)

    Attiogbe, Julien; Aubonnet, Emilie; De Maquille, Laurence; De Moura, Patrick; Desnoyers, Yvon; Dubot, Didier; Feret, Bruno; Fichet, Pascal; Granier, Guy; Iooss, Bertrand; Nokhamzon, Jean-Guy; Ollivier Dehaye, Catherine; Pillette-Cousin, Lucien; Savary, Alain

    2014-12-01

    This report presents the general methodology and best practice approaches which combine proven existing techniques for sampling and characterisation to assess the contamination of soils prior to remediation. It is based on feedback of projects conducted by main French nuclear stakeholders involved in the field of remediation and dismantling (EDF, CEA, AREVA and IRSN). The application of this methodology will enable the project managers to obtain the elements necessary for the drawing up of files associated with remediation operations, as required by the regulatory authorities. It is applicable to each of the steps necessary for the piloting of remediation work-sites, depending on the objectives targeted (release into the public domain, re-use, etc.). The main part describes the applied statistical methodology with the exploratory analysis and variogram data, identification of singular points and their location. The results obtained permit assessment of a mapping to identify the contaminated surface and subsurface areas. It stakes the way for radiological site characterisation since the initial investigations from historical and functional analysis to check that the remediation objectives have been met. It follows an example application from the feedback of the remediation of a contaminated site on the Fontenay aux Roses facility. It is supplemented by a glossary of main terms used in the field from different publications or international standards. This technical report is a support of the ISO Standard ISO ISO/TC 85/SC 5 N 18557 'Sampling and characterisation principles for soils, buildings and infrastructures contaminated by radionuclides for remediation purposes'. (authors) [fr

  20. Activity Recognition Invariant to Sensor Orientation with Wearable Motion Sensors.

    Science.gov (United States)

    Yurtman, Aras; Barshan, Billur

    2017-08-09

    Most activity recognition studies that employ wearable sensors assume that the sensors are attached at pre-determined positions and orientations that do not change over time. Since this is not the case in practice, it is of interest to develop wearable systems that operate invariantly to sensor position and orientation. We focus on invariance to sensor orientation and develop two alternative transformations to remove the effect of absolute sensor orientation from the raw sensor data. We test the proposed methodology in activity recognition with four state-of-the-art classifiers using five publicly available datasets containing various types of human activities acquired by different sensor configurations. While the ordinary activity recognition system cannot handle incorrectly oriented sensors, the proposed transformations allow the sensors to be worn at any orientation at a given position on the body, and achieve nearly the same activity recognition performance as the ordinary system for which the sensor units are not rotatable. The proposed techniques can be applied to existing wearable systems without much effort, by simply transforming the time-domain sensor data at the pre-processing stage.