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Sample records for methodology combining innovation

  1. Innovation strategies in a fruit growers association impacts assessment by using combined LCA and s-LCA methodologies.

    Science.gov (United States)

    Tecco, Nadia; Baudino, Claudio; Girgenti, Vincenzo; Peano, Cristiana

    2016-10-15

    In the challenging world of territorial transformations within the agriculture, there is an increasing need for an integrated methodological framework of assessment that is able to reconcile the demand for solutions that are both economically sustainable and contribute to environmental and social improvement. This study aims to assess the introduction of innovation into agro-food systems by combining an environmental life cycle (LCA) assessment and a social life cycle assessment (s-LCA) to support the decision making process of a fruit growers co-op for the adoption of mulching and covering in raspberry farming. LCA and s-LCA have been applied independently under specific consistency requirements, selecting two scenarios to compare the impact with (1) and without (2) the innovation and then combined within a cause-effect chain. The interactions between the environment and socioeconomic components were considered within a nested frameset of business and territorial features. The total emissions from raspberry production in Scenario 1, according to the Global Warming Potential (GWP) Impact Category amounted to 2.2840kg of CO2 eq. In Scenario 2, the impact of production was associated with a GWP of 0.1682kg of CO2 eq. Social repercussions analysis from Scenario 1 compared to Scenario 2 indicate more satisfaction for working conditions and the management of climate risks. The mulching and covering, implemented within a given framework of farm activity, created conditions for the preservation of a model in which raspberry production contributes to landscape protection, the business sustainability of farms and the creation of employment. The combined use of the two methods contributes to the development of a strategy planning due to its ability to deliver, as well as specific analysis at a functional level, a wider framework for assessing the consistency of the impacts related to innovation in raspberry production. Copyright © 2016 Elsevier B.V. All rights reserved.

  2. Sustainable Innovation and Entrepreneurship Methodology

    DEFF Research Database (Denmark)

    Celik, Sine; Joore, Peter; Christodoulou, Panayiotis

    or regional “co-creation platform for sustainable solutions” to promote structural innovation. In this manual, the Sustainable Innovation and Entrepreneurship Methodology will be described. The organisational guidelines mainly take point of departure in how Aalborg University (AAU) in Denmark has organised......The objective of the InnoLabs project is to facilitate cross-sectoral, multidisciplinary solutions to complex social problems in various European settings. InnoLabs are university-driven physical and/or organizational spaces that function as student innovation laboratories and operate as a local...... this in daily practice. In line with the objectives of the Innolabs project (output 05), partners in the Innolabs project have reflected, evaluated and concluded the project experiences, which are described in this report. The InnoLabs project was developed for the 2014 call of Erasmus+ funds KA2- Cooperation...

  3. The impact of methodology in innovation measurement

    Energy Technology Data Exchange (ETDEWEB)

    Wilhelmsen, L.; Bugge, M.; Solberg, E.

    2016-07-01

    Innovation surveys and rankings such as the Community Innovation Survey (CIS) and Innovation Union Scoreboard (IUS) have developed into influential diagnostic tools that are often used to categorize countries according to their innovation performance and to legitimise innovation policies. Although a number of ongoing processes are seeking to improve existing frameworks for measuring innovation, there are large methodological differences across countries in the way innovation is measured. This causes great uncertainty regarding a) the coherence between data from innovation surveys, b) actual innovativeness of the economy, and c) the validity of research based on innovation data. Against this background we explore empirically how different survey methods for measuring innovation affect reported innovation performance. The analysis is based on a statistical exercise comparing the results from three different methodological versions of the same survey for measuring innovation in the business enterprise sector in Norway. We find striking differences in reported innovation performance depending on how the surveys are carried out methodologically. The paper concludes that reported innovation performance is highly sensitive to and strongly conditioned by methodological context. This represents a need for increased caution and awareness around data collection and research based on innovation data, and not least in terms of aggregation of data and cross-country comparison. (Author)

  4. Working methodologically on system innovations

    NARCIS (Netherlands)

    Vogelezang, J.V.M.; Wijnands, F.G.

    2011-01-01

    Dutch agriculture is facing the challenge to develop into a sustainable sector. To achieve this goal, innovations are needed which force breaks with past trends and speed up the tempo of sustainable development. The System Innovation Programmes developed by Wageningen UR contribute with new,

  5. Software Innovation - Values for a Methodology

    DEFF Research Database (Denmark)

    Aaen, Ivan

    2013-01-01

    Innovation is a recurrent theme in public as well as academic debate, and software development plays a major role for innovation in about every sector of our economy. As a consequence, software innovation will play an increasingly important role in software development. The focus in this paper is...... for experimentation, learning, and flexibility in software projects, but how can this change be used to facilitate software innovation? This paper proposes a set of values to guide the development of a methodology to facilitate software innovation....

  6. Methodological bases of innovative training of specialists in nanotechnology field

    Directory of Open Access Journals (Sweden)

    FIGOVSKY Oleg Lvovich

    2016-10-01

    Full Text Available The performance of innovative training system aimed at highly intellectual specialists in the area of nanotechnologies for Kazakhstan’s economy demands establishment and development of nanotechnological market in the country, teaching of innovative engineering combined with consistent research, integration of trained specialists with latest technologies and sciences at the international level. Methodological aspects of training competitive specialists for nanotechnological field are specific. The paper presents methodological principles of innovative training of specialists for science-intensive industry that were realized according to grant given by the Ministry of Education and Science of the Republic of Kazakhstan.

  7. Methodology for combining dynamic responses

    International Nuclear Information System (INIS)

    Cudlin, R.; Hosford, S.; Mattu, R.; Wichman, K.

    1978-09-01

    The NRC has historically required that the structural/mechanical responses due to various accident loads and loads caused by natural phenomena, (such as earthquakes) be combined when analyzing structures, systems, and components important to safety. Several approaches to account for the potential interaction of loads resulting from accidents and natural phenomena have been used. One approach, the so-called absolute or linear summation (ABS) method, linearly adds the peak structural responses due to the individual dynamic loads. In general, the ABS method has also reflected the staff's conservative preference for the combination of dynamic load responses. A second approach, referred to as SRSS, yields a combined response equal to the square root of the sum of the squares of the peak responses due to the individual dynamic loads. The lack of a physical relationship between some of the loads has raised questions as to the proper methodology to be used in the design of nuclear power plants. An NRR Working Group was constituted to examine load combination methodologies and to develop a recommendation concerning criteria or conditions for their application. Evaluations of and recommendations on the use of the ABS and SRSS methods are provided in the report

  8. A methodology to measure the degre of managerial innovation

    OpenAIRE

    Ayhan, Mustafa Batuhan; Oztemel, Ercan

    2014-01-01

    Purpose: The main objective of this study is to introduce the concept of managerial innovation and to propose a quantitative methodology to measure the degree of managerial innovation capability by analyzing the evolution of the techniques used for management functions.Design/methodology/approach: The methodology mainly focuses on the different techniques used for each management functions namely; Planning, Organizing, Leading, Controlling and Coordinating. These functions are studied and the...

  9. Methodological classification of innovative engineering projects

    NARCIS (Netherlands)

    Zwart, S.D.; de Vries, M.J.; Franssen, M.; Vermaas, P.E.; Kroes, P.; Meijers, A.W.M.

    2016-01-01

    In this chapter we report on and discuss our empirical classification of innovative engineering projects. Basic innovative engineering projects are characterized by their overall goal and accompanying method. On the basis of this goal and method, we classify engineering projects as all falling in

  10. Knowledge and continuous innovation. The CIMA methodology

    NARCIS (Netherlands)

    Boer, Harm; Caffyn, Sarah; Corso, Mariano; Coughlan, Paul; Gieskes, J.F.B.; Magnusson, Mats; Pavesi, S.; Ronchi, Stefano

    2001-01-01

    Competition today is forcing companies to increase their effectiveness through exploiting synergy and learning in product innovation. Literature, however, is still mainly focused on how product development projects, seen largely as isolated efforts, should be organised and managed. This article

  11. Biomedical device innovation methodology: applications in biophotonics

    Science.gov (United States)

    Beswick, Daniel M.; Kaushik, Arjun; Beinart, Dylan; McGarry, Sarah; Yew, Ming Khoon; Kennedy, Brendan F.; Maria, Peter Luke Santa

    2018-02-01

    The process of medical device innovation involves an iterative method that focuses on designing innovative, device-oriented solutions that address unmet clinical needs. This process has been applied to the field of biophotonics with many notable successes. Device innovation begins with identifying an unmet clinical need and evaluating this need through a variety of lenses, including currently existing solutions for the need, stakeholders who are interested in the need, and the market that will support an innovative solution. Only once the clinical need is understood in detail can the invention process begin. The ideation phase often involves multiple levels of brainstorming and prototyping with the aim of addressing technical and clinical questions early and in a cost-efficient manner. Once potential solutions are found, they are tested against a number of known translational factors, including intellectual property, regulatory, and reimbursement landscapes. Only when the solution matches the clinical need, the next phase of building a "to market" strategy should begin. Most aspects of the innovation process can be conducted relatively quickly and without significant capital expense. This white paper focuses on key points of the medical device innovation method and how the field of biophotonics has been applied within this framework to generate clinical and commercial success.

  12. A methodology to measure the degre of managerial innovation

    Directory of Open Access Journals (Sweden)

    Mustafa Batuhan Ayhan

    2014-01-01

    Full Text Available Purpose: The main objective of this study is to introduce the concept of managerial innovation and to propose a quantitative methodology to measure the degree of managerial innovation capability by analyzing the evolution of the techniques used for management functions.Design/methodology/approach: The methodology mainly focuses on the different techniques used for each management functions namely; Planning, Organizing, Leading, Controlling and Coordinating. These functions are studied and the different techniques used for them are listed. Since the techniques used for these management functions evolve in time due to technological and social changes, a methodology is required to measure the degree of managerial innovation capability. This competency is measured through an analysis performed to point out which techniques used for each of these functions.Findings: To check the validity and applicability of this methodology, it is implemented to a manufacturing company. Depending on the results of the implementation, enhancements are suggested to the company for each function to survive in the changing managerial conditionsResearch limitations/implications: The primary limitation of this study is the implementation area. Although the study is implemented in just a single manufacturing company, it is welcomed to apply the same methodology to measure the managerial innovation capabilities of other manufacturing companies. Moreover, the model is ready to be adapted to different sectors although it is mainly prepared for manufacturing sector.Originality/value: Although innovation management is widely studied, managerial innovation is a new concept and introduced to measure the capability to challenge the changes occur in managerial functions. As a brief this methodology aims to be a pioneer in the field of managerial innovation regarding the evolution of management functions. Therefore it is expected to lead more studies to inspect the progress of

  13. Service Innovation Methodologies II : How can new product development methodologies be applied to service innovation and new service development? : Report no 2 from the TIPVIS-project

    OpenAIRE

    Nysveen, Herbjørn; Pedersen, Per E.; Aas, Tor Helge

    2007-01-01

    This report presents various methodologies used in new product development and product innovation and discusses the relevance of these methodologies for service development and service innovation. The service innovation relevance for all of the methodologies presented is evaluated along several service specific dimensions, like intangibility, inseparability, heterogeneity, perishability, information intensity, and co-creation. The methodologies discussed are mainly collect...

  14. Methodology for combining dynamic responses. Technical report

    International Nuclear Information System (INIS)

    Mattu, R.K.

    1980-05-01

    Procedures in accordance with Appendix A of 10 CFR 50, GDC 2, call for an appropriate combination of the effects of the accident loads and loads caused by natural phenomena (such as earthquakes) to be reflected in the design bases of safety equipment. This requirement of interaction of loads has been implemented in various ways both within the NRC and the Nuclear Industry. An NRR Working Group constituted to examine load combination methodologies developed recommendations which were published in September 1978 as NUREG-0484, (PB-287 432). Revision 1 of NUREG-0484 extends the conclusions of the original NUREG-0484 on the use of SRSS methodology for the combination of SSE and LOCA responses beyond RCPB to any other ASME Section III, Class 1, 2, or 3 affected system, component or support, and provides criteria for the combination of dynamic responses other than SSE and LOCA

  15. An Innovative Synthesis Methodology for Process Intensification

    DEFF Research Database (Denmark)

    Lutze, Philip

    to improve a process. However, to date only a limited number have achieved implementation in industry, such as reactive distillation, dividing wall columns and reverse flow reactors. A reason for this is that the identification of the best PI option is neither simple nor systematic. That is to decide where......‐based solution approach. Starting from an analysis of existing processes, the methodology generates a set of PI process options. Subsequently, the initial search space is reduced through an ordered sequence of steps. As the search space decreases, more process details are added, increasing the complexity...

  16. Services for People Innovation Park – Planning Methodologies

    Directory of Open Access Journals (Sweden)

    Maria Angela Campelo de Melo

    2013-04-01

    Full Text Available This article aims to identify appropriate methodologies for the planning of a Services for People Innovation Park-SPIP, designed according to the model proposed by the Ibero-American Network launched by La Salle University of Madrid. Projected to form a network, these parks were conceived to provoke social change in their region, improving quality of life and social welfare, through knowledge, technology and innovation transfer and creation of companies focused on developing product and services to reduce social inequalities. Building a conceptual framework for the identification of planning methodologies compatible with the SPIP problemátique, this article analyses the theories of complex systems and adaptive planning, considering the particularities presented by Innovation Parks. The study deepens the understanding of the problems inherent in park planning, identifies the key issues to be considered during this process, and characterizes the SPIP as active adaptive complex system, suggesting methodologies more appropriate to its planning.

  17. Services for People Innovation Park – Planning Methodologies

    OpenAIRE

    Maria Angela Campelo de Melo; Lygia Magalhães Magacho

    2013-01-01

    This article aims to identify appropriate methodologies for the planning of a Services for People Innovation Park-SPIP, designed according to the model proposed by the Ibero-American Network launched by La Salle University of Madrid. Projected to form a network, these parks were conceived to provoke social change in their region, improving quality of life and social welfare, through knowledge, technology and innovation transfer and creation of companies focused on developing product and servi...

  18. Methodological Grounds of Managing Innovation Development of Restaurants

    OpenAIRE

    Naidiuk V. S.

    2013-01-01

    The goal of the article lies in identification and further development of methodological grounds of managing the innovation development of restaurants. Based on the data of the critical analysis of existing scientific views on interpretation of the essence of the "managing innovation development of an enterprise" notion, the article conducts clarification of this definition. In the result of the study the article builds up a cause-effect diagram of solution of the problem of ensuring efficien...

  19. Which Methodology Works Better? English Language Teachers' Awareness of the Innovative Language Learning Methodologies

    Science.gov (United States)

    Kurt, Mustafa

    2015-01-01

    The present study investigated whether English language teachers were aware of the innovative language learning methodologies in language learning, how they made use of these methodologies and the learners' reactions to them. The descriptive survey method was employed to disclose the frequencies and percentages of 175 English language teachers'…

  20. Methodological Grounds of Managing Innovation Development of Restaurants

    Directory of Open Access Journals (Sweden)

    Naidiuk V. S.

    2013-12-01

    Full Text Available The goal of the article lies in identification and further development of methodological grounds of managing the innovation development of restaurants. Based on the data of the critical analysis of existing scientific views on interpretation of the essence of the “managing innovation development of an enterprise” notion, the article conducts clarification of this definition. In the result of the study the article builds up a cause-effect diagram of solution of the problem of ensuring efficient management of the innovation development of a restaurant. The article develops a conceptual scheme of development and realisation of the strategy of innovation development in a restaurant. It experimentally confirms the hypothesis of availability of a very strong density of the feedback between resistance to innovation changes and a variable share of qualified personnel that is capable of permanent development (learning and generation of new ideas, in restaurants and builds a model of dependency between them. The prospects of further studies in this direction could become scientific studies directed at development of methodical approaches to identification of the level of innovation potential and assessment of efficiency of managing innovation development of different (by type, class, size, etc. restaurants. The obtained data could also be used for development of a new or improvement of the existing tools of strategic management of innovation development at the micro-level.

  1. Applying living lab methodology to enhance skills in innovation

    CSIR Research Space (South Africa)

    Herselman, M

    2010-07-01

    Full Text Available and which is also inline with the South African medium term strategic framework and the millennium goals of the Department of Science and Technology. Evidence of how the living lab methodology can enhance innovation skills was made clear during various...

  2. Public Sector’s Innovativeness: Theoretical and Methodological Perplexities

    Directory of Open Access Journals (Sweden)

    Ljubinka Joksimovic

    2018-03-01

    Full Text Available Research question: This article considers the problems of measuring public sector innovation by asking the question whether and why interpretation of the achievements regarding the public sector innovativeness might be questionable. Motivation: The most recent literature on public sector innovation reveals two perspectives. One of them is assertion that the public sector suffers an innovation deficit, while the other claims that it is actually more innovative than a common credit. Insights in the results from recent large studies of measuring public sector innovation have shown very high rates of innovations, higher than in private sector (between 50 % and 80 % of respondents have recorded at least one type innovation during the period of two years. The lack of a uniquely, or at least dominant, attitude regarding the above-mentioned standpoints represents the basic inspiration for the actualization of this problem. Idea: The aim of the paper is twofold: 1 to offer an overview of three established theoretical attempts (assimilation, demarcation and integrative dealing with public sector innovation, in order to present the evolution of the issue; 2 to prove that the inclination to more general over contextually specific understanding of innovation (and vice versa has an impact both on its operationalization and on the interpretation of the achievements. Findings: In spite of the fact that theoretical considerations show noticeable detachment from assimilation perspective, empirical studies still copy this approach and the associated methodology. Surveys introduced subjectivity through arbitrary interpretation of the innovation concept, choice of research techniques and respondents and using of non-measurable goals as indicators of innovation outputs. Since this has affected and overrated their outcomes, we have found that empirical studies have not provided reliable depiction of the state of affairs regarding the PSI. Contribution: Having

  3. Innovative development methodology based on the Toyota Way; Innovative Entwicklungsmethodik basierend auf dem Toyota Way

    Energy Technology Data Exchange (ETDEWEB)

    Ueda, T. [Toyota Motor Corp., Aichi (Japan)

    2007-07-01

    Since its foundation, Toyota has been innovating in each process of automobile production based on the ideas shown in the Toyoda Precepts. These innovations are not only innovations in the methodology for various development processes, but also in company philosophy models cultivated by development engineers during their daily job. These are known as the ''Toyota Way'' and its elements which include ''Continuous Improvement'', ''Challenge'', ''Respect for People'', ''Genchi Genbutsu'' and ''Teamwork''. Various technological innovations have already progressed in the process from engine development to production. Examples are the use of CAD (computer aided design) and structure analysis based on 3-D CAD data in hardware development, CFD (computational fluid dynamics) and visualization techniques in combustion system development, MBD (model based development), the related DOE (design of engineering) and new algorithms in software development, as well as new production strategies linked to the new techniques mentioned above. The development of Toyota's direct injection gasoline engine (Toyota D-4 engine) originated from a pre-combustion chamber system in the 1970's with the aim of purifying the exhaust gases when the future of catalyst technology was unpromising. This technology could not be mass-produced, but could subsequently go on to the, R and D of DISC (direct injection stratified charge). In 1996, the stratified charge lean combustion gasoline DI engine could then be launched as the first-generation Toyota D-4 engine. After the second-generation D-4 engine was developed, this technology has now acceded to the dual injection D-4 system (D-4S), which combines it with homogeneous charged stoichiometric combustion and port fuel injection. During this progress, innovative development methods have been used and improvements in production

  4. The Typology of Methodological Approaches to Development of Innovative Clusters

    Directory of Open Access Journals (Sweden)

    Farat Olexandra V.

    2017-06-01

    Full Text Available The aim of the article is to study the existing methodological approaches to assessing the development of enterprises for further substantiation of possibilities of their using by cluster associations. As a result of research, based on the analysis of scientific literature, the most applicable methodological approaches to assessing the development of enterprises are characterized. 8 methodical approaches to assessing the level of development of enterprises and 4 methodological approaches to assessing the level of development of clusters are singled out. Each of the approaches is characterized by the presence of certain advantages and disadvantages, but none of them allows to obtain a systematic assessment of all areas of cluster functioning, identify possible reserves for cluster competitiveness growth and characterize possible strategies for their future development. Taking into account peculiarities of the functioning and development of cluster associations of enterprises, we propose our own methodological approach for assessing the development of innovative cluster structures.

  5. Combination microwave ovens: an innovative design strategy.

    Science.gov (United States)

    Tinga, Wayne R; Eke, Ken

    2012-01-01

    Reducing the sensitivity of microwave oven heating and cooking performance to load volume, load placement and load properties has been a long-standing challenge for microwave and microwave-convection oven designers. Conventional design problem and solution methods are reviewed to provide greater insight into the challenge and optimum operation of a microwave oven after which a new strategy is introduced. In this methodology, a special load isolating and energy modulating device called a transducer-exciter is used containing an iris, a launch box, a phase, amplitude and frequency modulator and a coupling plate designed to provide spatially distributed coupling to the oven. This system, when applied to a combined microwave-convection oven, gives astounding performance improvements to all kinds of baked and roasted foods including sensitive items such as cakes and pastries, with the only compromise being a reasonable reduction in the maximum available microwave power. Large and small metal utensils can be used in the oven with minimal or no performance penalty on energy uniformity and cooking results. Cooking times are greatly reduced from those in conventional ovens while maintaining excellent cooking performance.

  6. Methodology evaluation of innovative projects under risk and uncertainty

    Directory of Open Access Journals (Sweden)

    2012-09-01

    Full Text Available This article deals with problems connected with the assessment of innovative projects in the context of risk and uncertainty, topical issues of evaluation of innovative projects at the present stage of development of the Russian economy. By the example of the solution of the "crossing the river" is considering the possibility of using hierarchical models to address it. In what follows, and compares the priorities of different groups of factors are given by calculating the overall costs and benefits. The paper provides a rationale for combined use of four aspects: the beneficial aspects of the decision (the benefits and opportunities and negative (costs and risks that may lead to the decision in question.

  7. Combined Innovation Policy: Linking Scientific and Practical Knowledge in Innovation Systems

    OpenAIRE

    Isaksen, Arne; Nilsson, Magnus

    2013-01-01

    New research indicates that firms combining the science-based STI (Science, Technology, Innovation) and the experience-based DUI (Doing, Using, Interacting) modes of innovation are more efficient when it comes to improving innovation capacity and competitiveness. With regard to innovation policy, the STI mode calls for a supply driven policy, typically aimed to commercialise research results. The DUI mode suggests a demand driven policy approach, such as supporting the development of new prod...

  8. EDUCATIONAL COACHING: A METHODOLOGICAL PROPOSAL TO INNOVATE IN THE CLASSROOM

    Directory of Open Access Journals (Sweden)

    Ofelia Arzate O.

    2013-09-01

    Full Text Available The purpose of the present research is to present an innovative proposal for the development of the classroom work, applying coaching as a method to strengthen generic competence in students of the degree in primary education, by investigation-action methodology managed to carry out a reflection on practice to implement strategies that directly impacted on the students academic performance, strategies are evaluated through an assessment of own 360o to assess skills such as: Collaborates with others to generate innovative projects and social impact, uses his creative and critical thinking, learns permanently, and uses of information and communication technologies, results allow us to observe that the students were able to improve their academic performance to achieve the goal proposed at the beginning of the course of 8.0, on the other hand the competence favored achieving a breakthrough of 7.01 percent in one semester which allows us to conclude that educational coaching is an excellent proposal that allows the development of skills in the learner.

  9. Public Sector’s Innovativeness: Theoretical and Methodological Perplexities

    OpenAIRE

    Ljubinka Joksimovic; Slavica Manic; Danica Jovic

    2018-01-01

    Research question: This article considers the problems of measuring public sector innovation by asking the question whether and why interpretation of the achievements regarding the public sector innovativeness might be questionable. Motivation: The most recent literature on public sector innovation reveals two perspectives. One of them is assertion that the public sector suffers an innovation deficit, while the other claims that it is actually more innovative than a common credit. Insights in...

  10. Identification of Good Practices in the Implementation of Innovative Learning Methodologies

    Science.gov (United States)

    Lincaru, Cristina; Ciuca, Vasilica; Grecu, Liliana; Atanasiu, Draga; Dragoiu, Codruta

    2011-01-01

    We intend to present the partial issues resulted from the development of the European Project DeInTRA "cooperation for innovative training methodologies deployment in the European Labour Market"--Stage 4: Identification of good practices in the implementation of innovative learning methodologies. This project is included into the…

  11. Combining expedited cleanup with innovative technology demonstrations

    International Nuclear Information System (INIS)

    Hagood, M.C.; Rohay, V.J.; Valcich, P.J.; Brouns, T.M.; Cameron, R.J.

    1993-04-01

    A Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) expedited response action (ERA) has been initiated at the Hanford Site, Washington, for the removal of carbon tetrachloride from contaminated soils to mitigate further contamination of the groundwater. Soil vapor extraction with aboveground collection and treatment was chosen as the preferred remedial technology for the first phase of the ERA. At the same time, innovative technology demonstrations are being conducted in coordination with the ERA to determine the viability of emerging technologies that can be used to characterize, remediate, and monitor carbon tetrachloride and cocontaminants. The overall goal is to improve the performance and decrease the costs of carbon tetrachloride remediation while maintaining a safe working environment

  12. METHODOLOGY TO EVALUATE THE INNOVATIVE ACTIVITY OF THE MEAT INDUSTRY

    Directory of Open Access Journals (Sweden)

    D. N. Bakaev

    2014-01-01

    Full Text Available The article considers the methods of estimation of innovative activity of the enterprise. Revealed advantages and disadvantages of the proposed techniques in various publications, devoted to the innovative development. Analysis of the works of domestic and foreign authors showed that the existing methods do not provide an adequate assessment of innovative activity of the enterprise. Asked to enter the integral indicator of innovative activity, which is the criterion of the dynamism of innovative activity of the enterprise, as measured by the speed and volume creation, promotion and use of innovations in economic activity of the enterprise. The proposed system of estimation of innovative activity of the enterprise is based on the following indicators: the ratio of personnel development, the growth rate of financial assets directed on conducting innovative activity of the enterprise, the coefficient for mastering new technologies, the growth rate of intellectual property. The assessment matrix integral indicator of innovative activity of the enterprise reflects the relationship of the indicators of innovative potential and innovative activity and includes a group of indicators, which allows the estimation of innovative activity of enterprises in various spheres of business: technological, organizational, marketing. The main advantages of the developed technique of estimation of level of innovative development of the enterprises of the meat industry is: an assessment of the level in dynamics; complex research of a level of innovation development; the possibility of comparison of actual values with the values of the indicators, assessments United experts. A feature of the proposed method is not only able to measure the level of innovation development in General, but diagnosis of individual factors. This allows you to determine which factors-the Torah must be activated to display the meat industry to a higher level of innovation development.

  13. Laboratory experiments in innovation research: A methodological overview and a review of the current literature

    OpenAIRE

    Brüggemann, Julia; Bizer, Kilian

    2016-01-01

    Innovation research has developed a broad set of methodological approaches in recent decades. In this paper, we propose laboratory experiments as a fruitful methodological addition to the existing methods in innovation research. Therefore, we provide an overview of the existing methods, discuss the advantages and limitations of laboratory experiments, and review experimental studies dealing with different fields of innovation policy, namely intellectual property rights, financi...

  14. Assessment of the impact of innovation processes: methodological approaches

    Directory of Open Access Journals (Sweden)

    Demilkhanova B.A.

    2016-12-01

    Full Text Available in the article the prospects of development of innovative processes at a regional level the system of indicators of assessment effective components of innovation potential of the region. A conclusion about the predominance in the economy of the regions under study investment options for updating technology has been made based on the calculation and analysis of indicators of innovation investment in the fixed capital.

  15. Knowledge, Innovation and Performance in SMEs: a new Methodology

    OpenAIRE

    Farace, Salvatore

    2015-01-01

    2013-2014 The role of innovation in SMEs is strategic in shaping the ability of the firm to compete; innovation depends on on the firms’ ability to identify, assimilate and exploit knowledge from all around. Generally, an important source of knowledge is the R&D because it helps the firm in developing an absorptive capacity (Cohen, Levinthal, 1989) and also it is a strategic input of the path to innovation. If the firm is too small to afford R&D expenses this important sourc...

  16. The Evaluation of Innovation in the IT Service Sector: Methodological and Empirical Aspects

    Directory of Open Access Journals (Sweden)

    Eglė Kazlauskienė

    2013-08-01

    Full Text Available Purpose — Nowadays services are comprehended as the key factor for economic activity, growth and employment. Developed economies are service-dominated though little is known about the innovation details in the service sector and this study field has been neglected for a while. The innovation in service sector activities needs to be thoroughly evaluated because innovation is an interconnected process and cannot be defined using one or few indicators. IT services are an integral part of contemporary life, particularly for business. It can be introduced and implemented in all fields, especially when the world is becoming more multidimensional. Innovation performance in the IT sector has been under-researched, despite the fact that IT service sector plays the innovation disseminator role in other sectors by appliance of IT products. Design/methodology/approach — Based on scientific literature and methodological aspects analyses, an empirical research methodology was designed and the qualitative research on innovation in information technology service sector was accomplished. Findings — The article presents methodological aspects of innovation evaluation in service sector and empirical aspects on innovation implementation and development in the IT service companies in Lithuania. Research limitations/implications — For more comprehensive understanding of innovation in service sector, especially in IT services, the theory of service innovation is necessary. Deeper understanding and perspectives on how innovation benefits the information technology sector should be revealed in further researches and the multi-country analysis is needed. Practical implications — The finding of the paper can be used to improve the development of innovation in information technology service companies and create a model for more exhaustive multi-country empirical researches. Originality/value — The impact of innovation and its development in information

  17. An Innovative Fuzzy-Logic-Based Methodology for Trend Identification

    International Nuclear Information System (INIS)

    Wang Xin; Tsoukalas, Lefteri H.; Wei, Thomas Y.C.; Reifman, Jaques

    2001-01-01

    A new fuzzy-logic-based methodology for on-line signal trend identification is introduced. The methodology may be used for detecting the onset of nuclear power plant (NPP) transients at the earliest possible time and could be of great benefit to diagnostic, maintenance, and performance-monitoring programs. Although signal trend identification is complicated by the presence of noise, fuzzy methods can help capture important features of on-line signals, integrate the information included in these features, and classify incoming NPP signals into increasing, decreasing, and steady-state trend categories. A computer program named PROTREN is developed and tested for the purpose of verifying this methodology using NPP and simulation data. The results indicate that the new fuzzy-logic-based methodology is capable of detecting transients accurately, it identifies trends reliably and does not misinterpret a steady-state signal as a transient one

  18. Social Innovation Role in Creating a Methodological Framework Adapted to Reality

    Directory of Open Access Journals (Sweden)

    Mariem Kchaich Ep Chedli

    2014-07-01

    Full Text Available Innovation remains a complex concept that can’t be analysed and researched by ignoring the definition and influences of all aspects and interactions which were identified in the innovation cycle. Consequently the paper initiate the development of a modern methodological framework to be applied for analysing business social innovations in its continuity to be used by companies to adapt their activities to the current market demands. These innovations are intended for running innovative company, with employees ready for new ideas. The research development has taken into analyse several approaches: the concept of social innovation, the manner of which social innovation can be analysed, focusing on methodological aspects and the third part presents the conclusions. Given the present economic crises effects, its societal and social consequences in a reduced interest for applied social innovation, people tend to choose not making changes in their life and work despite new and innovative ideas; this can be taken as an approach for to avoiding risks and activity disruptions. As results our expectations merge within the idea that a complex society requires complex answers at all problems and personalised applications of any new theory or idea. Therefore the purpose of the paper is to propose concrete ideas of social innovation that can be easily put into practice.

  19. Service innovation methodologies I : what can we learn from service innovation and new service development research? : report no 1 from the TIPVIS-project

    OpenAIRE

    Nysveen, Herbjørn; Pedersen, Per E.

    2007-01-01

    This report presents a review of service innovation and service development literature. The main purpose of the review is to identify normative implications for service innovation methodologies. Three separate reviews are conducted and reported; an open search review based on specific search terms of relevance to service innovation methodologies, a review of articles in four of the most influential journals on service innovation/service development, and a review focusing contri...

  20. Defining Innovation: Using Soft Systems Methodology to Approach the Complexity of Innovation in Educational Technology

    Science.gov (United States)

    Cox, Glenda

    2010-01-01

    This paper explores what educational technologists in one South African Institution consider innovation to be. Ten educational technologists in various faculties across the university were interviewed and asked to define and answer questions about innovation. Their answers were coded and the results of the overlaps in coding have been assimilated…

  1. Keys to creative-strategic innovation using transmedia methodology

    Directory of Open Access Journals (Sweden)

    Eduardo Pradanos Grijalvo

    2016-02-01

    Full Text Available This article gives rise to a disruptive vision in the advertising industry through the directtestimony of two professionals. It exposes the need to find new formulas to reach a societythat is increasingly hyper-connected, fragmented and mobile. And this is done by employingConnect and Develop methodology, taking on a transmedia approach to the solutions.

  2. Methodological Innovation for the Study of Request Production in Telecollaboration

    Science.gov (United States)

    Cunningham, D. Joseph

    2017-01-01

    Second language (L2) request production has long been a central area of inquiry in interlanguage pragmatics, including how L2 learners mitigate their requests and whether such strategies correspond to or differ from those of first language (L1) speakers. Methodologically, such research often involves elicited speech and tends to isolate the speech…

  3. Combining Innovation Systems and Global Value Chains for Development

    DEFF Research Database (Denmark)

    Jurowetzki, Roman; Lema, Rasmus; Lundvall, Bengt-Åke

    2018-01-01

    This paper contributes to ongoing work which seeks to bring together the national innovation system and global value chain literatures for the study of economic development. We depart from the view that such a new combination will be helpful both in enhancing understanding of socioeconomic...... processes in developing countries and in building a more useful knowledge base for action. To this aim, we combine bibliometric analysis with a qualitative review of work from both bodies of literature. The purpose is to inform a research agenda suited for policy-relevant studies of economic development...

  4. Methodological Improvements in Combining TMS and Functional MRI

    OpenAIRE

    Moisa, Marius

    2011-01-01

    Since 1997, when Bohning and colleagues demonstrated for the first time the feasibility of interleaving transcranial magnetic stimulation (TMS) with blood oxygenation level dependency functional magnetic resonance imaging (BOLD fMRI), this combination became a very promising techniques to study brain connectivity. However, the implementation of a reliable setup for interleaved TMS/fMRI is still technically challenging. In this thesis, I intended to further explore and develop methodological i...

  5. The Methodology of the Process of Formation of Innovation Management of Enterprises’ Development

    Directory of Open Access Journals (Sweden)

    Prokhorova Viktoriia V.

    2017-12-01

    Full Text Available The article is aimed at forming the methodology of process of innovation management of enterprises’ development in modern conditions. A study on formation of the essence of methodology was carried out, the stages of development of methods and means of scientific cognition were analyzed. The basic components of formation of methodology of innovation management of development of enterprises have been defined, i.e.: methods, types, principles, components, systematized aggregate. The relations of empirical and theoretical methods of scientific cognition were considered and defined. It has been determined that the increase of the volume and scope of scientific views, as well as the deepening of scientific knowledge in the disclosure of laws and regularities of functioning of real natural and social world, lead to the objective fact that is the desire of scientists to analyze methods and means by which modern innovative knowledge and views in the enterprise management system can be acquired and formed.

  6. Chemical plant innovative safety investments decision-support methodology.

    Science.gov (United States)

    Reniers, G L L; Audenaert, A

    2009-01-01

    This article examines the extent to which investing in safety during the creation of a new chemical installation proves profitable. The authors propose a management supporting cost-benefit model that identifies and evaluates investments in safety within a chemical company. This innovative model differentiates between serious accidents and less serious accidents, thus providing an authentic image of prevention-related costs and benefits. In classic cost-benefit analyses, which do not make such differentiations, only a rudimentary image of potential profitability resulting from investments in safety is obtained. The resulting management conclusions that can be drawn from such classical analyses are of a very limited nature. The proposed model, however, is applied to a real case study and the proposed investments in safety at an appointed chemical installation are weighed against the estimated hypothetical benefits resulting from the preventive measures to be installed at the installation. In the case-study carried out in question, it would appear that the proposed prevention investments are justified. Such an economic exercise may be very important to chemical corporations trying to (further) improve their safety investments.

  7. Market concentration, corporate governance and innovation: Partial and combined effects in US-listed firms

    Directory of Open Access Journals (Sweden)

    Mehmet Ugur

    2012-10-01

    Full Text Available Existing research on the relationship between market concentration and innovation has produced conflicting findings. In addition, the emerging literature on the relationship between corporate governance and innovation tends to focus only on partial effects of corporate governance on innovation. We aim to contribute to the debate by investigating both partial and combined effects of corporate governance and market concentration on innovation. Utilising a dataset for 1,400 non-financial US-listed companies and two-way cluster-robust estimation methodology, we report several findings. First, the relationship between market concentration and innovation is non-linear. Secondly, the relationship has a U-shape in the case of input measure of innovation (research and development - R&D – expenditures; but it has an inverted-U shape when net book-value of brands and patents is used as output measure of innovation. Third, corporate governance indicators such as anti-takeover defences and insider control tend to have a negative partial effect on R&D expenditures but a positive partial effect on net book-value of brands and patents. Finally, when interacted with market concentration, anti-takeover defences and insider control act as complements to market concentration. Hence, firms with strong anti-take-over defences and under insider control tend to spend more on R&D but are less able to generate valuable brands and patents as market concentration increases. These results are based on two-way cluster-robust estimation, which takes account of both serial and cross-sectional dependence in the error terms.

  8. Technological innovation and valorisation of traditional food: a sustainable combination?

    Directory of Open Access Journals (Sweden)

    Marco Dalla Rosa

    2009-10-01

    Full Text Available Valorization of traditional foods is nowadays a key element for market developments where national industries are strongly involved in saving product peculiarity against imitative food coming from foreign countries or even different continents. Other than the lack in well defined and garanteed sensorial quality, the production conditions, the quality of raw material and the different cultural background lead to produce foods that, despite to the name indicating some italian origin or recallin in some ways Italy and italian food and traditions, are only imitation without safety and quality proper of the original traditional food. Thus it is necessary to individuate appropriated technologies and strategies to increase le level of garantee offered to the consumer in order to promote the consumption of traditional foods with the promised quality and safety. In this paper the role that the modern food technology and the food science can assume to improve the processing conditions and yields, introducing some innovations into the old processes will be pointed out. Furthermore, the characterization of the complexity of the chemical, chemico-physical and rheological properties that influence the whole sensorial aspect of traditional foods, both from animal and vegetal (and fruit origin, is a growing challenge of the food science since the new analytical methodologies now available. In the paper some example of objective characterization and introduction of innovation steps are reported as well as genuinity marker individuation in order to give sustainability to the production of traditional foods in particular in SME.

  9. The methodological features of managing the value of companies introducing "green" innovations

    Directory of Open Access Journals (Sweden)

    Kharin Alexander

    2012-03-01

    Full Text Available Although it is a common assumption that innovations are one of the most important factors of economic development, there is a need to review some provisions of innovation methodology so that new fundamental values are taken into account more fully. Most recent business models are based on the depletion of natural environment, whose potential has been almost exhausted. It is necessary to introduce new ideas that are of use for society and create values for companies. One way of achieving this goal is “green” (environmental innovations. The next decade is expected to see a rapid growth in environmental innovations. Their organization and management will require modern — and adequate to the objectives set —technologies. One of those is the quest for value methodology. To date, the quest for value methodology has given rise to several conceptual approaches, which can be used to evaluate the effectiveness of environmental innovations. This article discusses the advantages and disadvantages of major approaches. The author comes to a conclusion that that the modern theory and practice of corporate finance still lacks a generally accepted approach to assessing the value of companies that explicitly takes into account the impact of environmental factors on the cost. The article outlines the basic theoretical frameworks for the formation of such approach.

  10. Designing an AHP methodology to prioritize critical elements for product innovation: an intellectual capital perspective

    Directory of Open Access Journals (Sweden)

    Costa, R. V.

    2015-08-01

    Full Text Available Intellectual capital has for the past decades been evidenced as an important source of competitive advantages and differentiation at the firm level. At the same time, innovation has become a critical factor for companies to ensure their sustainability and even their survival in a globalized business landscape. Having in mind these two crucial concepts for business success, this study intends to build on the relationships between intellectual capital and product innovation at the firm level. Specifically, we will design and test a model based on the Analytic Hierarchy Process, whose aim is to allow the prioritization of intellectual capital elements according to their relative importance for product innovation performance at the firm level. The main goal of this research is to build a diagnosis and action tool that helps business managers incorporate an intellectual capital perspective into their product innovation initiatives. This framework will help managers to better understand which intellectual capital elements are more critical to their product innovation efforts, and thereby systematize actions and clarify resource allocation priorities to improve their product innovation capabilities. In order to validate the practicability of this proposal, the methodology was empirically applied to a Portuguese innovative company.

  11. Forward Commitment Procurement : A practical methodology that helps to manage risk in procuring innovative goods and services

    NARCIS (Netherlands)

    Whyles, G.; Meerveld, H. van; Nauta, N.J.

    2015-01-01

    The Forward Commitment Procurement (FCP) is a Public Procurement of Innovation (PPI) methodology. It was specifically designed to both provide a practical methodology for procurers to follow and to manage the perceived risk of the customer and supplier in innovation investments. The paper describes

  12. SPECIFICS OF ELABORATING METHODOLOGY TO TEACH INNOVATIVE COMPETENCE USING EMBEDDABLE MODULE

    Directory of Open Access Journals (Sweden)

    Nikolai I. Naumkin

    2016-12-01

    structure, the core part, invariable and variable parts. The article reveals the potential of such integration in training students in innovative engineering activities within the core teaching methodology.

  13. DEVELOPMENT OF METHODOLOGY FOR THE CALCULATION OF THE PROJECT INNOVATION INDICATOR AND ITS CRITERIA COMPONENTS

    Directory of Open Access Journals (Sweden)

    Mariya Vishnevskaya

    2017-12-01

    Full Text Available Two main components of the problem studied in the article are revealed. At the practical level, the provision of the convenient tools allowing a comprehensive evaluation the proposed innovative project in terms of its possibilities for inclusion in the portfolio or development program, and on the level of science – the need for improvement and complementing the existing methodology of assessment of innovative projects attractiveness in the context of their properties and a specific set of components. The research is scientifically applied since the problem solution involves the science-based development of a set of techniques, allowing the practical use of knowledge gained from large information arrays at the initialization stage. The purpose of the study is the formation of an integrated indicator of the project innovation, with a substantive justification of the calculation method, as a tool for the evaluation and selection of projects to be included in the portfolio of projects and programs. The theoretical and methodological basis of the research is the conceptual provisions and scientific developments of experts on project management issues, published in monographs, periodicals, materials of scientific and practical conferences on the topic of research. The tasks were solved using the general scientific and special methods, mathematical modelling methods based on the system approach. Results. A balanced system of parametric single indicators of innovation is presented – the risks, personnel, quality, innovation, resources, and performers, which allows getting a comprehensive idea of any project already in the initial stages. The choice of a risk tolerance as a key criterion of the “risks” element and the reference characteristics is substantiated, in relation to which it can be argued that the potential project holds promise. A tool for calculating the risk tolerance based on the use of matrices and vector analysis is proposed

  14. Methodological Aspects in Forecasting Innovation Development of Dairy Cattle Breeding in the Region

    Directory of Open Access Journals (Sweden)

    Natal’ya Aleksandrovna Medvedeva

    2016-07-01

    Full Text Available Due to the fact that Russia is now a member of the World Trade Organization, long-term forecasting becomes an objectively necessary condition that helps choose an effective science-based long-term strategy for development of dairy cattle breeding that would take into consideration intellectual and innovative characteristics. Current structure of available statistical information does not meet modern challenges of innovation development and does not reflect adequately the trends of ongoing changes. The paper suggests a system of indicators to analyze the status, development and prospects of dairy cattle breeding in the region; this system provides timely identification of emerging risks and threats of deviation from the specified parameters. The system included indicators contained in the current statistical reporting and new indicators of innovation development of the industry, the quality of human capital and the level of government support. When designing the system of indicators, we used several methodological aspects of the Oslo Manual, which the Federal State Statistics Service considers to be an official methodological document concerning the collection of information about innovation activities. A structured system of indicators shifts the emphasis in the analysis of the final results to the conditions and prerequisites that help achieve forecast performance indicators in the functioning of Russia’s economy under WTO rules and make substantiated management decisions

  15. Stochastic techno-economic assessment based on Monte Carlo simulation and the Response Surface Methodology: The case of an innovative linear Fresnel CSP (concentrated solar power) system

    International Nuclear Information System (INIS)

    Bendato, Ilaria; Cassettari, Lucia; Mosca, Marco; Mosca, Roberto

    2016-01-01

    Combining technological solutions with investment profitability is a critical aspect in designing both traditional and innovative renewable power plants. Often, the introduction of new advanced-design solutions, although technically interesting, does not generate adequate revenue to justify their utilization. In this study, an innovative methodology is developed that aims to satisfy both targets. On the one hand, considering all of the feasible plant configurations, it allows the analysis of the investment in a stochastic regime using the Monte Carlo method. On the other hand, the impact of every technical solution on the economic performance indicators can be measured by using regression meta-models built according to the theory of Response Surface Methodology. This approach enables the design of a plant configuration that generates the best economic return over the entire life cycle of the plant. This paper illustrates an application of the proposed methodology to the evaluation of design solutions using an innovative linear Fresnel Concentrated Solar Power system. - Highlights: • A stochastic methodology for solar plants investment evaluation. • Study of the impact of new technologies on the investment results. • Application to an innovative linear Fresnel CSP system. • A particular application of Monte Carlo simulation and response surface methodology.

  16. Combining the technological innovation systems framework with the entrepreneurs’ perspective on innovation

    NARCIS (Netherlands)

    Planko, Julia; Cramer, Jacqueline; Hekkert, Marko P.; Chappin, Maryse M H

    2017-01-01

    For their technological sustainability innovations to become successful, entrepreneurs can strategically shape the technological field in which they are involved. The technological innovation systems (TISs) literature has generated valuable insights into the processes which need to be stimulated for

  17. Innovation and Integrity in Intervention Research: Conceptual Issues, Methodology, and Knowledge Translation.

    Science.gov (United States)

    Malti, Tina; Beelmann, Andreas; Noam, Gil G; Sommer, Simon

    2018-04-01

    In this article, we introduce the special issue entitled Innovation and Integrity in Intervention Science. Its focus is on essential problems and prospects for intervention research examining two related topics, i.e., methodological issues and research integrity, and challenges in the transfer of research knowledge into practice and policy. The main aims are to identify how to advance methodology in order to improve research quality, examine scientific integrity in the field of intervention science, and discuss future steps to enhance the transfer of knowledge about evidence-based intervention principles into sustained practice, routine activities, and policy decisions. Themes of the special issue are twofold. The first includes questions about research methodology in intervention science, both in terms of research design and methods, as well as data analyses and the reporting of findings. Second, the issue tackles questions surrounding the types of knowledge translation frameworks that might be beneficial to mobilize the transfer of research-based knowledge into practice and public policies. The issue argues that innovations in methodology and thoughtful approaches to knowledge translation can enable transparency, quality, and sustainability of intervention research.

  18. Understanding palliative care on the heart failure care team: an innovative research methodology.

    Science.gov (United States)

    Lingard, Lorelei A; McDougall, Allan; Schulz, Valerie; Shadd, Joshua; Marshall, Denise; Strachan, Patricia H; Tait, Glendon R; Arnold, J Malcolm; Kimel, Gil

    2013-05-01

    There is a growing call to integrate palliative care for patients with advanced heart failure (HF). However, the knowledge to inform integration efforts comes largely from interview and survey research with individual patients and providers. This work has been critically important in raising awareness of the need for integration, but it is insufficient to inform solutions that must be enacted not by isolated individuals but by complex care teams. Research methods are urgently required to support systematic exploration of the experiences of patients with HF, family caregivers, and health care providers as they interact as a care team. To design a research methodology that can support systematic exploration of the experiences of patients with HF, caregivers, and health care providers as they interact as a care team. This article describes in detail a methodology that we have piloted and are currently using in a multisite study of HF care teams. We describe three aspects of the methodology: the theoretical framework, an innovative sampling strategy, and an iterative system of data collection and analysis that incorporates four data sources and four analytical steps. We anticipate that this innovative methodology will support groundbreaking research in both HF care and other team settings in which palliative integration efforts are emerging for patients with advanced nonmalignant disease. Copyright © 2013 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.

  19. Function combined method for design innovation of children's bike

    Science.gov (United States)

    Wu, Xiaoli; Qiu, Tingting; Chen, Huijuan

    2013-03-01

    As children mature, bike products for children in the market develop at the same time, and the conditions are frequently updated. Certain problems occur when using a bike, such as cycle overlapping, repeating function, and short life cycle, which go against the principles of energy conservation and the environmental protection intensive design concept. In this paper, a rational multi-function method of design through functional superposition, transformation, and technical implementation is proposed. An organic combination of frog-style scooter and children's tricycle is developed using the multi-function method. From the ergonomic perspective, the paper elaborates on the body size of children aged 5 to 12 and effectively extracts data for a multi-function children's bike, which can be used for gliding and riding. By inverting the body, parts can be interchanged between the handles and the pedals of the bike. Finally, the paper provides a detailed analysis of the components and structural design, body material, and processing technology of the bike. The study of Industrial Product Innovation Design provides an effective design method to solve the bicycle problems, extends the function problems, improves the product market situation, and enhances the energy saving feature while implementing intensive product development effectively at the same time.

  20. COMBINATION THERAPIES OR STANDALONE INTERVENTIONS? INNOVATION OPTIONS FOR PHARMACEUTICAL FIRMS FIGHTING CANCER

    OpenAIRE

    GUNJAN BHARDWAJ; ANSHIT AGRAWAL; RUPESH TYAGI

    2015-01-01

    Innovation is key to the pharma model, from an initial discovery to the final development of a marketable drug. Here, we explore the innovation options in the fiercely contested therapeutic area of Oncology. We studied clinical development of drugs targeting PD-1 and PD-L1 pathway. In this interesting contest, companies seem to be focusing on standalone interventions (exploratory innovation) and combination therapy (exploitative innovation) in clinical development. Merck Sharp and Dohme, havi...

  1. Methodological considerations in evaluating a proliferation resistance of innovative nuclear energy systems

    International Nuclear Information System (INIS)

    Kikuchi, Masahiro; Takaki, Naoyuki; Murajiri, Masahiro; Nakagome, Yoshihiro; Tokiwai, Moriyasu

    2004-01-01

    Over 25 years ago, INFCE studied the evaluation methodology of proliferation resistance. Recently, INPRO and GEN-IV coordinated by the IAEA and the USDOE respectively seek an appropriate innovative fuel cycle system for next generation that is furnished safer, sustainable, economical and reliable features. The evaluation methodology of the proliferation resistance is also assigned as an essential part of both studies. The IAEA established and has been strictly implementing the verification measures with accurate material accountancy system from the early of the 1970s in order to detect diversion of plutonium that is individually separated from irradiated nuclear material and recycled as MOX fuel. This paper firstly identifies the impedibility of intrinsic features of innovative fuel cycles and the safeguardability of selected nonproliferation measures as two individual essential parameters for evaluation of a proliferation resistance capability. As a next step, this paper also shows methodological considerations in evaluating the proliferation resistance levels as a multiple model of several clusters that are identified the ability of each parameter. (author)

  2. National assessment study in Armenia using innovative nuclear reactors and fuel cycles methodology for an innovative nuclear systems in a country with small grid

    International Nuclear Information System (INIS)

    Sargsyan, V.H.; Galstyan, A.A.; Gevorgyan, A.A.

    2010-01-01

    The International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) was launched in November 2000 under the aegis of the IAEA. Phases 1A and IB (first Part) of the Project were dedicated to elaboration, testing and validation of the INPRO Methodology. At the Technical Meeting in Vienna (13-15 October 2004) Armenia has proposed an assessment using the INPRO Methodology for an Innovative Nuclear Energy System in a country with a small electrical grid. Such kind of study helps Armenia in analysis of Innovative Nuclear Energy System (INS), including fuel cycle options, as well as shows applicability of INPRO methodology for small countries, like Armenia. This study was based on the results given in [3] and [4], and also on the main objectives, declared by the Government of Armenia in the paper 'Energy Sector Development Strategies in the Context of Economic Development in Armenia'

  3. Learning and innovation: a methodological proposal from the teaching of Media Management

    Directory of Open Access Journals (Sweden)

    F Peinado-Miguel

    2013-02-01

    Full Text Available After its adaptation to the EHEA, the Department of Journalism IV of the Complutense University of Madrid began a project of methodological renovation and educational innovation –linked to an R&D project– in the teaching of Media Management, with the aim of providing future communication professionals with the skills required by the new business reality. The project was developed in different stages and was structured along the following lines of action: use of ICTs and Web 2.0 tools to develop activities that put new energy into the learning process: podcasts, interviews with executive directors and managers, entrepreneurial projects 2.0, intensive use of the Virtual Campus and blogs. In addition the teaching innovation project involved collaborative work to resolve real cases, with the implementation of the Educlick system’s software and hardware. This article presents the foundations and results of the new learning methodology model, which could be extrapolated to the teaching of other subjects of journalism

  4. Creating Innovative Research Designs: The 10-Year Methodological Think Tank Case Study

    Science.gov (United States)

    Katerndahl, David; Crabtree, Benjamin

    2006-01-01

    PURPOSE Addressing important but complex research questions often necessitates the creation of innovative mixed methods designs. This report describes an approach to developing research designs for studying important but methodologically challenging research questions. METHODS The Methodological Think Tank has been held annually in conjunction with the Primary Care Research Methods and Statistics Conference in San Antonio since 1994. A group of 3 to 4 methodologists with expertise balanced between quantitative and qualitative backgrounds is invited by the think tank coordinators to serve on a 2-day think tank to discuss a research question selected from those submitted in response to a call for proposals. During the first half-day, these experts explore the content area with the investigator, often challenging beliefs and assumptions. During the second half-day, the think tank participants systematically prune potential approaches until a desirable research method is identified. RESULTS To date, the most recent 7 think tanks have produced fundable research designs, with 1 being funded by a K award and 4 by R01 grants. All participating investigators attributed much of their success to think tank participation. Lessons learned include (1) the importance of careful selection of participating methodologists, (2) all think tank communities of inquiry must go through 4 stages of development from pseudocommunity to community, and (3) the critical importance of listening by the investigator. CONCLUSION Researchers and academic departments could use this process locally to develop innovative research designs. PMID:17003146

  5. Innovative research methods for studying treatments for rare diseases: methodological review.

    Science.gov (United States)

    Gagne, Joshua J; Thompson, Lauren; O'Keefe, Kelly; Kesselheim, Aaron S

    2014-11-24

    To examine methods for generating evidence on health outcomes in patients with rare diseases. Methodological review of existing literature. PubMed, Embase, and Academic Search Premier searched for articles describing innovative approaches to randomized trial design and analysis methods and methods for conducting observational research in patients with rare diseases. We assessed information related to the proposed methods, the specific rare disease being studied, and outcomes from the application of the methods. We summarize methods with respect to their advantages in studying health outcomes in rare diseases and provide examples of their application. We identified 46 articles that proposed or described methods for studying patient health outcomes in rare diseases. Articles covered a wide range of rare diseases and most (72%) were published in 2008 or later. We identified 16 research strategies for studying rare disease. Innovative clinical trial methods minimize sample size requirements (n=4) and maximize the proportion of patients who receive active treatment (n=2), strategies crucial to studying small populations of patients with limited treatment choices. No studies describing unique methods for conducting observational studies in patients with rare diseases were identified. Though numerous studies apply unique clinical trial designs and considerations to assess patient health outcomes in rare diseases, less attention has been paid to innovative methods for studying rare diseases using observational data. © Gagne et al 2014.

  6. Application of extended statistical combination of uncertainties methodology for digital nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    In, Wang Ki; Uh, Keun Sun; Chul, Kim Heui [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1995-02-01

    A technically more direct statistical combinations of uncertainties methodology, extended SCU (XSCU), was applied to statistically combine the uncertainties associated with the DNBR alarm setpoint and the DNBR trip setpoint of digital nuclear power plants. The modified SCU (MSCU) methodology is currently used as the USNRC approved design methodology to perform the same function. In this report, the MSCU and XSCU methodologies were compared in terms of the total uncertainties and the net margins to the DNBR alarm and trip setpoints. The MSCU methodology resulted in the small total penalties due to a significantly negative bias which are quite large. However the XSCU methodology gave the virtually unbiased total uncertainties. The net margins to the DNBR alarm and trip setpoints by the MSCU methodology agree with those by the XSCU methodology within statistical variations. (Author) 12 refs., 17 figs., 5 tabs.

  7. Combining artefact analysis, interview and participant observation to study the organizational sensemaking of knowledge-based innovation

    OpenAIRE

    Reischauer, Georg

    2015-01-01

    "Innovation studies have hardly investigated the link between innovation and organization with respect to what individual actors in organizations mean when they refer to innovation. More precisely, there are few research designs with the goal to understand (Verstehen) the meaning of innovation in organizations. To address this gap on a methodological level, I introduce an interpretative research design to study the organizational sense-making of innovation. Informed by the knowledge-based vie...

  8. Latest developments in innovative manufacturing to combine nanotechnology with healthcare

    OpenAIRE

    Parhizkar, M.; Mahalingam, S.; Homer-Vanniasinkam, S.; Edirisinghe, M.

    2017-01-01

    Nanotechnology has become increasingly important in advancing the frontiers of many key areas of healthcare, for example, drug delivery and tissue engineering. To fully harness the many benefits of nanotechnology in healthcare, innovative manufacturing is necessary to mass produce nanoparticles and nanofibers, the two major types of nanofeatures currently sought after and of immense utilitarian value in healthcare. For example, nanoparticles are a key drug delivery enabler, the structural and...

  9. An Innovative Structural Mode Selection Methodology: Application for the X-33 Launch Vehicle Finite Element Model

    Science.gov (United States)

    Hidalgo, Homero, Jr.

    2000-01-01

    An innovative methodology for determining structural target mode selection and mode selection based on a specific criterion is presented. An effective approach to single out modes which interact with specific locations on a structure has been developed for the X-33 Launch Vehicle Finite Element Model (FEM). We presented Root-Sum-Square (RSS) displacement method computes resultant modal displacement for each mode at selected degrees of freedom (DOF) and sorts to locate modes with highest values. This method was used to determine modes, which most influenced specific locations/points on the X-33 flight vehicle such as avionics control components, aero-surface control actuators, propellant valve and engine points for use in flight control stability analysis and for flight POGO stability analysis. Additionally, the modal RSS method allows for primary or global target vehicle modes to also be identified in an accurate and efficient manner.

  10. Study on commercial FBR concepts by combining innovative technologies

    International Nuclear Information System (INIS)

    Miura, M.; Inagaki, T.; Kuroha, M.; Hida, T.

    1992-01-01

    A study was conducted on future prospects of FBR commercialization. Targets of further improving safety and economy were set to make commercial power plants that would be superior to future LWRs. Promising innovative technologies studied domestically and overseas were extracted by evaluating prospects for commercialization, effect, and plant applicability. Several commercial plants were conceptualized by introducing such technology to large-scale and oxide-fuel reactors. Estimates of construction cost, etc., proved that the targets could be achieved. A concept of long-term technological development was synthesized. (author)

  11. INNOVATIVE APPROACHES TO RESEARCH METHODOLOGY OF SOCIAL RESPONSIBILITY IN THE FIELD OF RISK MANAGEMENT

    Directory of Open Access Journals (Sweden)

    L. Volokhova

    2016-06-01

    Full Text Available The paper defines the role of insurance and risk management in corporate social responsibility. Analysed some of the social problems of certain sectors of the economy and the distribution of investments by insurance companies in a socially-oriented areas of the economy. The result of the analysis show that the problem of insurance and risk management should be directed to the development of innovative insurance products that would receive specific corporate social value by real locating investments. To better study on strategic risk - management must diversify and improve the traditionally accepted methodological tools. We consider the theory of positional feedback and corresponding IRT innovative model for analysis of complex, highly-defined characteristics of this sector. In order to determine a common objective evaluation system of corporate social responsibility for all companies emphasis on practical social benefits as measuring the effectiveness and success of socially responsible activities, the benefits that the company will receive from the decision of the social project. The proposed comprehensive system of indicators based insurance, which allows you to deepen the study of social responsibility in risk management strategies. The indicator system includes the following sections: 1. Navkolyshnye environment. 2. Local government (social security community. 3. Occupational Safety. 4. Internal corporate relations. 5. Equality. 6. Product Attributes. 7. Management. 8. The interest of business. 9. Liability business. 10. Socially responsible insurance. The comparative characteristic of the efficacy of social activity of companies and assess their socio-oriented activities for the previous ten years.

  12. Methodological Foundations of Clustering and Innovativeness for Establishing the Competitive Production of Biofuels

    Directory of Open Access Journals (Sweden)

    Klymchuk Oleksandr V.

    2016-05-01

    Full Text Available The article is aimed to study the worldwide trends in development of innovative processes and creation of cluster structures for elaborating methodological foundations for establishing the competitive production of biofuels. The article highlights the cluster approaches in conducting the global commercial activities that create effective mechanisms and tools to encourage innovation-investment regional development and can be characterized by their relevance for the Ukrainian economy. Emphasis is made on the matter that clustering is one of the key tools for structuring the energy market, integrated exploiting the potential of bioenergy industry sector, management of the economic policies of redistribution of value added, implementation of the growth of investment attractiveness of the biofuel industry in our country. It has been concluded that cluster development in the biofuel production will stimulate specialization and cooperation processes in the agro-industrial economy sector, bringing together related businesses in the direction of an effective interaction, thereby ensuring a high level of competitiveness of biofuels in both the national and the international markets.

  13. Lessons from innovation in drug-device combination products.

    Science.gov (United States)

    Couto, Daniela S; Perez-Breva, Luis; Saraiva, Pedro; Cooney, Charles L

    2012-01-01

    Drug-device combination products introduced a new dynamic on medical product development, regulatory approval, and corporate interaction that provide valuable lessons for the development of new generations of combination products. This paper examines the case studies of drug-eluting stents and transdermal patches to facilitate a detailed understanding of the challenges and opportunities introduced by combination products when compared to previous generations of traditional medical or drug delivery devices. Our analysis indicates that the largest barrier to introduce a new kind of combination products is the determination of the regulatory center that is to oversee its approval. The first product of a new class of combination products offers a learning opportunity for the regulator and the sponsor. Once that first product is approved, the leading regulatory center is determined, and the uncertainty about the entire class of combination products is drastically reduced. The sponsor pioneering a new class of combination products assumes a central role in reducing this uncertainty by advising the decision on the primary function of the combination product. Our analysis also suggests that this decision influences the nature (pharmaceutical, biotechnology, or medical devices) of the companies that will lead the introduction of these products into the market, and guide the structure of corporate interaction thereon. Copyright © 2011 Elsevier B.V. All rights reserved.

  14. Approaches for the Assessment of the Innovative Nuclear System of Ukraine on the Base of INPRO Methodology

    International Nuclear Information System (INIS)

    Afanas'ev, A.A.; Vlasenko, N.I.

    2007-01-01

    Approaches for the preliminary and comparative assessment of Innovative Nuclear System (INS) of Ukraine using INPRO methodology (IAEA TECDOC-1434) suggested for the period up to 2030, which must answer the comprehensive purpose of sustainable development, contribute to strengthening of the non-proliferation principles and solving an energy problems supply on national and regional levels are presented in the paper. Using assessment results of the INS based on evolutionary designs will allow Ukraine to build informative, methodological and technical basis for choice of the INS based on innovative design which could be offered for deployment in Ukraine after 1030

  15. Combining communication technology utilization and organizational innovation: evidence from Canadian healthcare decision makers.

    Science.gov (United States)

    Jbilou, Jalila; Landry, Réjean; Amara, Nabil; El Adlouni, Salaheddine

    2009-08-01

    Information and Communication Technology (ICT) and Organizational Innovation (OI) are seen as the miracle of post-modernity in organizations. In this way, they are supposed to resolve most organizational problems, efficiently and rapidly. OI is highly dependent on the capacity and the investment in knowledge management (internal and external) to support decision making process and to implement significant changes. We know what explains ICT utilization (ICTU) and what determines OI development (OID) in healthcare services. Moreover, the literature tends to link ICTU to OID and vice versa. However, this dependency has never been explored empirically through the lens of roles combination. To identify the existing combined roles profiles of ICTU and OID among healthcare decision makers and determine factors of the shift from a profile to another. We did the following: (1) a structured review of the literature on healthcare management by focusing on ICTU and OID which allowed us to build two indexes and a comprehensive framework; (2) a copula methodology to identify with high precision the thresholds for ICTU and OID; and (3) a cross-sectional study based on a survey done with a sample of 942 decision makers from Canadian healthcare organizations through a multinomial logit model to identify determinants of the shift. ICTU and OID are correlated at 22% (Kendal's Tau). The joint distribution (combination) of ICTU and OID shows that four major profiles exist among decision makers in Canadian healthcare organizations: the traditional decision maker, the innovative decision maker, the technologic decision maker and the contemporary decision maker. We found out that classic factors act as barriers to the shift from one profile to the desired profile (from 1 to 4, from 2 to 4 and from 3 to 4). We have identified that the attitude toward research and relational capital are transversal barriers of shift. We have also found that some factors have a specific impact such as

  16. An innovative methodology for the transmission of information, using Sensor Web Enablement, from ongoing research vessels.

    Science.gov (United States)

    Sorribas, Jordi; Sinquin, Jean Marc; Diviacco, Paolo; De Cauwer, Karien; Danobeitia, Juanjo; Olive, Joan; Bermudez, Luis

    2013-04-01

    Research vessels are sophisticated laboratories with complex data acquisition systems for a variety of instruments and sensors that acquire real-time information of many different parameters and disciplines. The overall data and metadata acquired commonly spread using well-established standards for data centers; however, the instruments and systems on board are not always well described and it may miss significant information. Thus, important information such as instrument calibration or operational data often does not reach to the data center. The OGC Sensor Web Enablement standards provide solutions to serve complex data along with the detailed description of the process used to obtain them. We show an innovative methodology on how to use Sensor Web Enablement standards to describe and serve information from the research vessels, the data acquisition systems used onboard, and data sets resulting from the onboard work. This methodology is designed to be used in research vessels, but also applies to data centers to avoid loss of information in between The proposed solution considers (I) the difficulty to describe a multidisciplinary and complex mobile sensor system, (II) it can be easily integrated with data acquisition systems onboard, (III) it uses the complex and incomplete typical vocabulary in marine disciplines, (IV) it provides contacts with the data and metadata services at the Data Centers, and (V) it manages the configuration changes with time of the instrument.

  17. Combining innovative technology demonstrations with dense nonaqueous phase liquids cleanup

    International Nuclear Information System (INIS)

    Hagood, M.C.; Koegler, K.J.; Rohay, V.J.; Trent, S.J.; Stein, S.L.; Brouns, T.M.; McCabe, G.H.; Tomich, S.

    1993-05-01

    Radioactively contaminated acidic aqueous wastes and organic liquids were discharged to the soil column at three disposal sites within the 200 West Area of the Hanford Site, Washington. As a result, a portion of the underlying groundwater is contaminated with carbon tetrachloride several orders of magnitude above the maximum contaminant level accepted for a drinking water supply. Treatability testing and cleanup actions have been initiated to remove the contamination from both the unsaturated soils to minimize further groundwater contamination and the groundwater itself. To expedite cleanup, innovative technologies for (1) drilling, (2) site characterization, (3) monitoring, (4) well field development, and (5) contaminant treatment are being demonstrated and subsequently used where possible to improve the rates and cost savings associated with the removal of carbon tetrachloride from the soils and groundwater

  18. Innovation

    Science.gov (United States)

    EPA frames innovation as critical to the protection of human health and the environment through initiatives such as sustainable practices, innovative research, prize competitions, innovation awards, partnerships, and community activities.

  19. Knowledge base combinations and innovation performance in Swedish regions

    Czech Academy of Sciences Publication Activity Database

    Grillitsch, M.; Martin, R.; Srholec, Martin

    2017-01-01

    Roč. 93, č. 5 (2017), s. 458-479 ISSN 0013-0095 Institutional support: Progres-Q24 Keywords : knowledge base * knowledge combination * region Subject RIV: AH - Economics OBOR OECD: Applied Economics, Econometrics Impact factor: 5.344, year: 2016

  20. Knowledge base combinations and innovation performance in Swedish regions

    Czech Academy of Sciences Publication Activity Database

    Grillitsch, M.; Martin, R.; Srholec, Martin

    2017-01-01

    Roč. 93, č. 5 (2017), s. 458-479 ISSN 0013-0095 Institutional support: RVO:67985998 Keywords : knowledge base * knowledge combination * region Subject RIV: AH - Economics OBOR OECD: Applied Economics, Econometrics Impact factor: 5.344, year: 2016

  1. Tracing the transition path between optimal strategies combinations within a competitive market of innovative industrial products

    Science.gov (United States)

    Batzias, Dimitris F.; Pollalis, Yannis A.

    2012-12-01

    In several cases, a competitive market can be simulated by a game, where each company/opponent is referred to as a player. In order to accommodate the fact that each player (alone or with alliances) is working against some others' interest, the rather conservative maximin criterion is frequently used for selecting the strategy or the combination of strategies that yield the best of the worst possible outcomes for each one of the players. Under this criterion, an optimal solution is obtained when neither player finds it beneficial to alter his strategy, which means that an equilibrium has been achieved, giving also the value of the game. If conditions change as regards a player, e.g., because of either achieving an unexpected successful result in developing an innovative industrial product or obtaining higher liquidity permitting him to increase advertisement in order to acquire a larger market share, then a new equilibrium is reached. The identification of the path between the old and the new equilibrium points may prove to be valuable for investigating the robustness of the solution by means of sensitivity analysis, since uncertainty plays a critical role in this situation, where evaluation of the payoff matrix is usually based on experts' estimates. In this work, the development of a standard methodology (including 16 activity stages and 7 decision nodes) for tracing this path is presented while a numerical implementation follows to prove its functionality.

  2. Assessment of two small-sized innovative nuclear reactors for electricity generation in Brazil using INPRO methodology

    International Nuclear Information System (INIS)

    Goncalves Filho, Orlando Joao Agostinho; Sefidvash, Farhang

    2009-01-01

    This paper presents the main results of the assessment study of two small-sized innovative reactors for electricity generation in Brazil using the methodology developed under the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO), co-ordinated by the International Atomic Energy Agency (IAEA). INPRO was initiated in 2001 and has the main objective of helping to ensure that nuclear energy is available to contribute in a sustainable manner to the energy needs of the 21st century. Brazil joined the INPRO project since its beginning and in 2005 submitted a proposal for the assessment using INPRO methodology of two small-sized reactors (IRIS - International Reactor Innovative and Secure, and FBNR - Fixed Bed Nuclear Reactor) as potential components of an innovative nuclear energy system (INS) completed by a conventional open nuclear fuel cycle based on enriched uranium. The scope of this assessment study was restricted to the reactor component of the INS and to the methodology areas of economics and safety for IRIS, and proliferation resistance and safety for FBNR. The results indicate that both IRIS and FBNR innovative designs comply mostly with the basic principles of the areas assessed and have potential to comply with the remaining ones. (author)

  3. Facilitating innovation : an action-oriented approach and participatory methodology to improve innovative social practice in agriculture

    OpenAIRE

    Engel, P.G.H.

    1995-01-01

    This study focuses upon the social organization of innovation. It makes use of insights from knowledge and information systems research, development sociology, management science and applied philosophy and seeks answers to the following questions: What do social actors, individuals and/or organizations, actually do to innovate their practices? How do they organize themselves? Can this be managed or facilitated, and if so, how? The research is exploratory rather than concl...

  4. A Methodology for Long-Term Analysis of Innovative Signalling Systems on Regional Rail Lines

    Directory of Open Access Journals (Sweden)

    Luca D'Acierno

    2016-10-01

    Full Text Available A rail system may be considered a useful tool for reducing vehicular flows on a road system (i.e. cars and trucks, especially in high-density contexts such as urban and metropolitan areas where greenhouse gas emissions need to be abated. In particular, since travellers maximise their own utility, variations in mobility choices can be induced only by significantly improving the level-of-service of public transport. Our specific proposal is to identify the economic and environmental effects of implementing an innovative signalling system (which would reduce passenger waiting times by performing a cost-benefit analysis based on a feasibility threshold approach. Hence, it is necessary to calculate long-term benefits and compare them with intervention costs. In this context, a key factor to be considered is travel demand estimation in current and future conditions. This approach was tested on a regional rail line in southern Italy to show the feasibility and utility of the proposed methodology.

  5. Using Innovative Methodologies From Technology and Manufacturing Companies to Reduce Heart Failure Readmissions.

    Science.gov (United States)

    Johnson, Amber E; Winner, Laura; Simmons, Tanya; Eid, Shaker M; Hody, Robert; Sampedro, Angel; Augustine, Sharon; Sylvester, Carol; Parakh, Kapil

    2016-05-01

    Heart failure (HF) patients have high 30-day readmission rates with high costs and poor quality of life. This study investigated the impact of a framework blending Lean Sigma, design thinking, and Lean Startup on 30-day all-cause readmissions among HF patients. This was a prospective study in an academic hospital in Baltimore, Maryland. Thirty-day all-cause readmission was assessed using the hospital's electronic medical record. The baseline readmission rate for HF was 28.4% in 2010 with 690 discharges. The framework was developed and interventions implemented in the second half of 2011. The impact of the interventions was evaluated through 2012. The rate declined to 18.9% among 703 discharges (P < .01). There was no significant change for non-HF readmissions. This study concluded that methodologies from technology and manufacturing companies can reduce 30-day readmissions in HF, demonstrating the potential of this innovations framework to improve chronic disease care. © The Author(s) 2014.

  6. User requirements for innovative nuclear reactors and fuel cycle technologies in the area of economics, environment, safety, waste management, proliferation resistance and cross cutting issues, and methodology for innovative technologies assessment

    International Nuclear Information System (INIS)

    Kupitz, Juergen; Depisch, Frank; Allan, Colin

    2003-01-01

    The IAEA General Conference in 2000 has invited ''all interested Member States to combine their efforts under the aegis of the Agency in considering the issues of the nuclear fuel cycle, in particular by examining innovative and proliferation-resistant nuclear technology''. In response to this invitation, the IAEA initiated an ''International Project on Innovative Nuclear Reactors and Fuel Cycles'', INPRO. The overall objectives of INPRO is to help to ensure that nuclear energy is available to contribute in fulfilling in a sustainable manner energy needs in the 21st century, and to bring together all interested Member States, both technology holders and technology users, to consider jointly the international and national actions required to achieve desired innovations in nuclear reactors and fuel cycles that use sound and economically competitive technology. Phase-I of INPRO was initiated in May 2001. During Phase-I, work was subdivided in two sub phase: Phase 1A (finished in June 2003) and Phase 1B (started in June 2003). Phase 1A dealt with the definition of Basic Principles, User Requirements and Criteria, and the development of a methodology for the evaluation of innovative nuclear technologies. In Phase 1A, task groups for several areas were established: (a) Prospects and Potentials of Nuclear Power, (b) Economics; (c) Sustainability and Environment, (d) Safety of Nuclear Installations, (e) Waste Management, (f) Proliferation Resistance, (g) Crosscutting issues and (h) for the Methodology for Assessment. In Phase-IB evaluations of innovative nuclear energy technologies will be performed by Member States against the INPRO Basic Principles, User Requirements and Criteria. This paper summarizes the results achieved in the Phase 1A of INPRO and is a cooperative effort of the INPRO team, consisting of all INPRO cost free experts and task managers. (author)

  7. The increasing of national competitiveness. The methodology of training the innovators

    Directory of Open Access Journals (Sweden)

    Alexandru GRIBINCEA

    2017-06-01

    Full Text Available According to the dictionary, an innovator is someone who performs and introduces something new in a field; person who brings an innovation in the production sector, resulting in improved quality and quantity of the work. Often innovator is a highly-qualified specialist, able to generate innovative offers in some areas having a positive impact. The author refers to multiple information and knowledge from different fields and applied sciences such as mathematics, physics, biology, chemistry, philosophy, economics, political science and law in the elaboration of innovative offers. According to these requirements, the innovator must have knowledge in these fields of science and practice. The aim of the research is to reveal some elements in the development and implementation of innovations as knowledge in various fields of science and technology, physics, chemistry, biology, and other fields necessary for innovators.

  8. Failure mode effect analysis and fault tree analysis as a combined methodology in risk management

    Science.gov (United States)

    Wessiani, N. A.; Yoshio, F.

    2018-04-01

    There have been many studies reported the implementation of Failure Mode Effect Analysis (FMEA) and Fault Tree Analysis (FTA) as a method in risk management. However, most of the studies usually only choose one of these two methods in their risk management methodology. On the other side, combining these two methods will reduce the drawbacks of each methods when implemented separately. This paper aims to combine the methodology of FMEA and FTA in assessing risk. A case study in the metal company will illustrate how this methodology can be implemented. In the case study, this combined methodology will assess the internal risks that occur in the production process. Further, those internal risks should be mitigated based on their level of risks.

  9. Facilitating innovation : an action-oriented approach and participatory methodology to improve innovative social practice in agriculture

    NARCIS (Netherlands)

    Engel, P.G.H.

    1995-01-01

    This study focuses upon the social organization of innovation. It makes use of insights from knowledge and information systems research, development sociology, management science and applied philosophy and seeks answers to the following questions: What do social actors, individuals and/or

  10. Combined strategic and tactical negotiation methodology for resolving complex brownfield conflicts

    Directory of Open Access Journals (Sweden)

    Keith W. Hipel

    2010-08-01

    Full Text Available An innovative negotiation methodology for strategic and tactical decision making is proposed for resolving conflicts in brownfield redevelopment. At the strategic level, the Graph Model for Conflict Resolution is systematically employed for determining a potential overall agreement, or set of resolutions, that is politically possible given the competing interests of the decision makers involved in a brownfield redevelopment project. At the tactical level, a possible strategic solution can be studied in depth using utility theory to determine trade-offs or concessions needed to reach a mutually acceptable detailed solution. Also, the proposed negotiation methodology can take into account the attitudes of negotiators and investigates the impact of the negotiators' attitudes on the outcome of negotiations at both levels of negotiation. The design of a negotiation decision support system is put forward to allow the proposed negotiation methodology to be conveniently applied to actual disputes.

  11. The innovation of cryo-SEM freeze-fracturing methodology demonstrated on high pressure frozen biofilm.

    Science.gov (United States)

    Hrubanova, Kamila; Nebesarova, Jana; Ruzicka, Filip; Krzyzanek, Vladislav

    2018-04-22

    In this study we present an innovative method for the preparation of fully hydrated samples of microbial biofilms of cultures Staphylococcus epidermidis, Candida parapsilosis and Candida albicans. Cryo-scanning electron microscopy (cryo-SEM) and high-pressure freezing (HPF) rank among cutting edge techniques in the electron microscopy of hydrated samples such as biofilms. However, the combination of these techniques is not always easily applicable. Therefore, we present a method of combining high-pressure freezing using EM PACT2 (Leica Microsystems), which fixes hydrated samples on small sapphire discs, with a high resolution SEM equipped with the widely used cryo-preparation system ALTO 2500 (Gatan). Using a holder developed in house, a freeze-fracturing technique was applied to image and investigate microbial cultures cultivated on the sapphire discs. In our experiments, we focused on the ultrastructure of the extracellular matrix produced during cultivation and the relationships among microbial cells in the biofilm. The main goal of our investigations was the detailed visualization of areas of the biofilm where the microbial cells adhere to the substrate/surface. We show the feasibility of this technique, which is clearly demonstrated in experiments with various freeze-etching times. Copyright © 2018 Elsevier Ltd. All rights reserved.

  12. Bilingualism and cognitive reserve: A critical overview and a plea for methodological innovations

    Directory of Open Access Journals (Sweden)

    Noelia eCalvo

    2016-01-01

    Full Text Available The decline of cognitive skills throughout healthy or pathological aging can be slowed down by experiences which foster cognitive reserve (CR. Recently, some studies on Alzheimer’s disease have suggested that CR may be enhanced by life-long bilingualism. However, the evidence is inconsistent and based on retrospective approaches featuring several methodological weaknesses. Some studies demonstrated at least four years of delay in dementia symptoms, while others did not find such an effect. Moreover, various methodological aspects vary from study to study. The present paper addresses contradictory findings, identifies possible lurking variables, and outlines methodological alternatives thereof. First, we characterize possible confounding factors that may have influenced extant results. Our focus is on the criteria to establish bilingualism, differences in sample design, the instruments used to examine cognitive skills, and the role of variables known to modulate life-long cognition. Second, we propose that these limitations could be largely circumvented through experimental approaches. Proficiency in the non-native language can be successfully assessed by combining subjective and objective measures; confounding variables which have been distinctively associated with certain bilingual groups (e.g., alcoholism, sleep disorders can be targeted through relevant instruments; and cognitive status might be better tapped via robust cognitive screenings and executive batteries. Moreover, future research should incorporate tasks yielding predictable patterns of contrastive performance between bilinguals and monolinguals. Crucially, these include instruments which reveal bilingual disadvantages in vocabulary, null effects in working memory, and advantages in inhibitory control and other executive functions. Finally, paradigms tapping proactive interference (which assess the disruptive effect of long-term memory on newly learned information could also

  13. Bilingualism and Cognitive Reserve: A Critical Overview and a Plea for Methodological Innovations.

    Science.gov (United States)

    Calvo, Noelia; García, Adolfo M; Manoiloff, Laura; Ibáñez, Agustín

    2015-01-01

    The decline of cognitive skills throughout healthy or pathological aging can be slowed down by experiences which foster cognitive reserve (CR). Recently, some studies on Alzheimer's disease have suggested that CR may be enhanced by life-long bilingualism. However, the evidence is inconsistent and largely based on retrospective approaches featuring several methodological weaknesses. Some studies demonstrated at least 4 years of delay in dementia symptoms, while others did not find such an effect. Moreover, various methodological aspects vary from study to study. The present paper addresses contradictory findings, identifies possible lurking variables, and outlines methodological alternatives thereof. First, we characterize possible confounding factors that may have influenced extant results. Our focus is on the criteria to establish bilingualism, differences in sample design, the instruments used to examine cognitive skills, and the role of variables known to modulate life-long cognition. Second, we propose that these limitations could be largely circumvented through experimental approaches. Proficiency in the non-native language can be successfully assessed by combining subjective and objective measures; confounding variables which have been distinctively associated with certain bilingual groups (e.g., alcoholism, sleep disorders) can be targeted through relevant instruments; and cognitive status might be better tapped via robust cognitive screenings and executive batteries. Moreover, future research should incorporate tasks yielding predictable patterns of contrastive performance between bilinguals and monolinguals. Crucially, these include instruments which reveal bilingual disadvantages in vocabulary, null effects in working memory, and advantages in inhibitory control and other executive functions. Finally, paradigms tapping proactive interference (which assess the disruptive effect of long-term memory on newly learned information) could also offer useful data

  14. Bilingualism and Cognitive Reserve: A Critical Overview and a Plea for Methodological Innovations

    Science.gov (United States)

    Calvo, Noelia; García, Adolfo M.; Manoiloff, Laura; Ibáñez, Agustín

    2016-01-01

    The decline of cognitive skills throughout healthy or pathological aging can be slowed down by experiences which foster cognitive reserve (CR). Recently, some studies on Alzheimer's disease have suggested that CR may be enhanced by life-long bilingualism. However, the evidence is inconsistent and largely based on retrospective approaches featuring several methodological weaknesses. Some studies demonstrated at least 4 years of delay in dementia symptoms, while others did not find such an effect. Moreover, various methodological aspects vary from study to study. The present paper addresses contradictory findings, identifies possible lurking variables, and outlines methodological alternatives thereof. First, we characterize possible confounding factors that may have influenced extant results. Our focus is on the criteria to establish bilingualism, differences in sample design, the instruments used to examine cognitive skills, and the role of variables known to modulate life-long cognition. Second, we propose that these limitations could be largely circumvented through experimental approaches. Proficiency in the non-native language can be successfully assessed by combining subjective and objective measures; confounding variables which have been distinctively associated with certain bilingual groups (e.g., alcoholism, sleep disorders) can be targeted through relevant instruments; and cognitive status might be better tapped via robust cognitive screenings and executive batteries. Moreover, future research should incorporate tasks yielding predictable patterns of contrastive performance between bilinguals and monolinguals. Crucially, these include instruments which reveal bilingual disadvantages in vocabulary, null effects in working memory, and advantages in inhibitory control and other executive functions. Finally, paradigms tapping proactive interference (which assess the disruptive effect of long-term memory on newly learned information) could also offer useful data

  15. Innovation

    DEFF Research Database (Denmark)

    Nielsen, Janni; Yaganeh, Suzanne; Bloch Rasmussen, Leif

    2013-01-01

    This paper contributes to a theoretical discussion of creation of innovation with participants in, or outside, organisations. We address the creation of innovation with a complex theoretical understanding drawing on the Scandinavian and the Participatory Design tradition introducing two approaches...... to the processes of innovation. We ask if innovation can be initiated and enhanced looking at two collaborative approaches; participatory innovation (PIN) and cooperative innovation (COIN). We invite to dialogue and reflections on PIN’s conflict and creative frictions on one side and COIN’s complexity......, complementarity in diversity and the didactic scaffolding of the innovation process on the other side. Our contribution focuses on the methods and practices for facilitation of co-creating activities between different groups leading to cooperation, and innovation in thinking....

  16. Disordered Gambling Prevalence: Methodological Innovations in a General Danish Population Survey.

    Science.gov (United States)

    Harrison, Glenn W; Jessen, Lasse J; Lau, Morten I; Ross, Don

    2018-03-01

    We study Danish adult gambling behavior with an emphasis on discovering patterns relevant to public health forecasting and economic welfare assessment of policy. Methodological innovations include measurement of formative in addition to reflective constructs, estimation of prospective risk for developing gambling disorder rather than risk of being falsely negatively diagnosed, analysis with attention to sample weights and correction for sample selection bias, estimation of the impact of trigger questions on prevalence estimates and sample characteristics, and distinguishing between total and marginal effects of risk-indicating factors. The most significant novelty in our design is that nobody was excluded on the basis of their response to a 'trigger' or 'gateway' question about previous gambling history. Our sample consists of 8405 adult Danes. We administered the Focal Adult Gambling Screen to all subjects and estimate prospective risk for disordered gambling. We find that 87.6% of the population is indicated for no detectable risk, 5.4% is indicated for early risk, 1.7% is indicated for intermediate risk, 2.6% is indicated for advanced risk, and 2.6% is indicated for disordered gambling. Correcting for sample weights and controlling for sample selection has a significant effect on prevalence rates. Although these estimates of the 'at risk' fraction of the population are significantly higher than conventionally reported, we infer a significant decrease in overall prevalence rates of detectable risk with these corrections, since gambling behavior is positively correlated with the decision to participate in gambling surveys. We also find that imposing a threshold gambling history leads to underestimation of the prevalence of gambling problems.

  17. Methodology and key determinants of building an efficient national innovation system of a country

    Directory of Open Access Journals (Sweden)

    Viktoriia Gurova

    2015-12-01

    Full Text Available The paper represents a research of theoretical principles for determining national innovation systems, as well as analyzes performance results displayed by national innovation systems of the leading countries in the global innovation space, while also describing characteristic features thereof and formulating recommendations for NIS build-up based on the same, implementation of which should serve as the basis of the national innovation system effective performance. It has been determined that at the current stage of global economy development such factors as science, technology and innovation play an important role in formation of a competitive economy. It has been established that the overall funding level with respect to science proves one of the key characteristics of an innovative country, and therefore NIS performance analysis was carried out based on the national expenditure indicator regarding research and development as well as on the country's position in the Global Innovation Index. The analysis carried out showed that the NISs of certain countries were more efficient than those of the others due to peculiarities of the innovative system elements that can be further referred to as determinants of building an effective national innovation system of a country

  18. Combining several thermal indices to generate a unique heat comfort assessment methodology

    Directory of Open Access Journals (Sweden)

    Wissam EL Hachem

    2015-11-01

    Full Text Available Purpose: The proposed methodology hopes to provide a systematic multi-disciplinary approach to assess the thermal environment while minimizing unneeded efforts. Design/methodology/approach: Different factors affect the perception of the human thermal experience: metabolic rate (biology, surrounding temperatures (heat balance and environmental factors and cognitive treatment (physiology.This paper proposes a combination of different multidisciplinary variables to generate a unique heat comfort assessment methodology. The variables at stake are physiological, biological, and environmental. Our own heat analysis is thoroughly presented and all relevant equations are described. Findings: Most companies are oblivious about potential dangers of heat stress accidents and thus about methods to monitor and prevent them. This methodology enables the company or the concerned individual to conduct a preliminary assessment with minimal wasted resources and time in unnecessary steps whilst providing a guideline for a detailed study with minimal error rates if needed. More so, thermal comfort is an integral part of sound ergonomics practices, which in turn are decisive for the success of any lean six sigma initiative. Research limitations/implications: This methodology requires several full implementations to finalize its design. Originality/value: Most used heat comfort models are inherently uncertain and tiresome to apply. An extensive literature review confirms the need for a uniform assessment methodology that combines the different thermal comfort models such as the Fanger comfort model (PMV, PPD and WGBT since high error rates coupled with tiresome calculations often hinder the thermal assessment process.

  19. Integrated methodology for standard-setting norms of innovative product in the new competitive environment

    Science.gov (United States)

    Polyakova, Marina; Rubin, Gennadiy

    2017-07-01

    Modern theory of technological and economical development is based on long-term cycles. So far it has been proved that the technological structure of the economy can be subdivided into groups of technological complexes, which are inter-related with each other by similar technological links, so called technological modes. Technological mode is defined as a complex of interrelated production units of similar technological level, which develop simultaneously. In order to provide competitiveness of products in the new changing conditions, it is necessary to make sure that they meet all the regulatory requirements specified in standards. But the existing and the fast changing situation on the merchandise markets causes disbalance between the growing customer requirements and the technological capabilities of the manufacturer. This makes the issue of standardization development even more urgent both from the point of view of establishing the current positions and from the point of view of possible promising development trends in technology. In the paper scientific and engineering principles of developing standardization as a science are described. It is shown that further development of standardization is based on the principles of advanced standardization the main idea of which is to set up the prospective requirements to the innovative product. Modern approaches of advanced standardization are shown in this paper. The complexity of the negotiation procedure between customer and manufacturer as a whole and achieving of consensus, in particular, make it necessary to find conceptually new approaches to developing mathematical models. The developed methodology picture the process of achieving the consensus between customer and manufacturer while developing the standard norms in the form of decreasing S-curve diagram. It means that in the end of the negotiation process, there is no difference between customer and manufacturer positions. It makes it possible to provide the

  20. INTERPERSONAL COMMUNICATION AND METHODOLOGIES OF INNOVATION. A HEURISTIC EXPERIENCE IN THE CLASSROOM APPLYING SEMANTIC NETWORKS

    Directory of Open Access Journals (Sweden)

    José Manuel Corujeira Gómez

    2014-10-01

    Full Text Available The current definition of creativity gives importance to interpersonal communication in innovation strategies, and allows us to question the profiles of professionals –innovation partners– communication skills in the practice session in which they are applied. This text shows shallow results on the application of some of their tactics with a group of students. We tested structural/procedural descriptions of hypothetical effects of communication using indicators proposed by Network Theory in terms topologies provided by the group. Without a conclusive result, we expect this paper helps to the creativity's investigation in the innovation sessions.

  1. High-level methodology for carrying out combined red and blue teams

    CSIR Research Space (South Africa)

    Veerasamy, N

    2009-12-01

    Full Text Available This paper proposes a combined Red and Blue Team Methodology to guide the process of carrying out such security auditing and penetration testing tasks. Red and Blue Teams consist of various security auditing and penetration testing tasks which serve...

  2. Combining soft system methodology and pareto analysis in safety management performance assessment : an aviation case

    NARCIS (Netherlands)

    Karanikas, Nektarios

    2016-01-01

    Although reengineering is strategically advantageous for organisations in order to keep functional and sustainable, safety must remain a priority and respective efforts need to be maintained. This paper suggests the combination of soft system methodology (SSM) and Pareto analysis on the scope of

  3. On Singularities and Black Holes in Combination-Driven Models of Technological Innovation Networks.

    Directory of Open Access Journals (Sweden)

    Ricard Solé

    Full Text Available It has been suggested that innovations occur mainly by combination: the more inventions accumulate, the higher the probability that new inventions are obtained from previous designs. Additionally, it has been conjectured that the combinatorial nature of innovations naturally leads to a singularity: at some finite time, the number of innovations should diverge. Although these ideas are certainly appealing, no general models have been yet developed to test the conditions under which combinatorial technology should become explosive. Here we present a generalised model of technological evolution that takes into account two major properties: the number of previous technologies needed to create a novel one and how rapidly technology ages. Two different models of combinatorial growth are considered, involving different forms of ageing. When long-range memory is used and thus old inventions are available for novel innovations, singularities can emerge under some conditions with two phases separated by a critical boundary. If the ageing has a characteristic time scale, it is shown that no singularities will be observed. Instead, a "black hole" of old innovations appears and expands in time, making the rate of invention creation slow down into a linear regime.

  4. On Singularities and Black Holes in Combination-Driven Models of Technological Innovation Networks.

    Science.gov (United States)

    Solé, Ricard; Amor, Daniel R; Valverde, Sergi

    2016-01-01

    It has been suggested that innovations occur mainly by combination: the more inventions accumulate, the higher the probability that new inventions are obtained from previous designs. Additionally, it has been conjectured that the combinatorial nature of innovations naturally leads to a singularity: at some finite time, the number of innovations should diverge. Although these ideas are certainly appealing, no general models have been yet developed to test the conditions under which combinatorial technology should become explosive. Here we present a generalised model of technological evolution that takes into account two major properties: the number of previous technologies needed to create a novel one and how rapidly technology ages. Two different models of combinatorial growth are considered, involving different forms of ageing. When long-range memory is used and thus old inventions are available for novel innovations, singularities can emerge under some conditions with two phases separated by a critical boundary. If the ageing has a characteristic time scale, it is shown that no singularities will be observed. Instead, a "black hole" of old innovations appears and expands in time, making the rate of invention creation slow down into a linear regime.

  5. Innovators.

    Science.gov (United States)

    NEA Today, 2001

    2001-01-01

    Describes various innovations that have been developed to enhance education. These innovations include: helping educators help at-risk students succeed; promoting high school journalism; ensuring quality online learning experiences; developing a student performing group that uses theater to address social issues; and having students design their…

  6. Towards integration of methodologies for assessing and promoting the societal embedding of energy innovations

    International Nuclear Information System (INIS)

    Verbong, G.; Mourik, R.; Raven, R.P.J.M.

    2006-10-01

    The necessity for system innovation is well acknowledged, but inducing system change proves to be very difficult. Three approaches have been developed for analysing and supporting radical innovations: Socrobust, Create Acceptance and Strategic Niche Management. This paper gives an overview of these complementary approaches and their theoretical background. The paper also identifies several potential contributions for social scientists to contribute to energy research and the implementation of more sustainable alternatives.

  7. Scrum Methodology in Higher Education: Innovation in Teaching, Learning and Assessment

    Science.gov (United States)

    Jurado-Navas, Antonio; Munoz-Luna, Rosa

    2017-01-01

    The present paper aims to detail the experience developed in a classroom of English Studies from the Spanish University of Málaga, where an alternative project-based learning methodology has been implemented. Such methodology is inspired by scrum sessions widely extended in technological companies where staff members work in teams and are assigned…

  8. Innovative Mixed-Methods Research: Moving beyond Design Technicalities to Epistemological and Methodological Realizations

    Science.gov (United States)

    Riazi, A. Mehdi

    2016-01-01

    Mixed-methods research (MMR), as an inter-discourse (quantitative and qualitative) methodology, can provide applied linguistics researchers the opportunity to draw on and integrate the strengths of the two research methodological approaches in favour of making more rigorous inferences about research problems. In this article, the argument is made…

  9. Innovation

    African Journals Online (AJOL)

    In recent years ULA has emphasized advocacy, and contributed to progress towards new legislation (freedom of information, copyright, the ... East African Community e-government strategy) of importance to the library and ... Innovation Vol.

  10. Innovative Methodology for Detection of Fracture-Controlled Sweet Spots in the Northern Appalachian Basin

    Energy Technology Data Exchange (ETDEWEB)

    Robert Jacobi; John Fountain; Stuart Loewenstein; Edward DeRidder; Bruce Hart

    2007-03-31

    For two consecutive years, 2004 and 2005, the largest natural gas well (in terms of gas flow/day) drilled onshore USA targeted the Ordovician Trenton/Black River (T/BR) play in the Appalachian Basin of New York State (NYS). Yet, little data were available concerning the characteristics of the play, or how to recognize and track T/BR prospects across the region. Traditional exploration techniques for entry into a hot play were of limited use here, since existing deep well logs and public domain seismic were almost non-existent. To help mitigate this problem, this research project was conceived with two objectives: (1) to demonstrate that integrative traditional and innovative techniques could be used as a cost-effective reconnaissance exploration methodology in this, and other, areas where existing data in targeted fracture-play horizons are almost non-existent, and (2) determine critical characteristics of the T/BR fields. The research region between Seneca and Cayuga lakes (in the Finger Lakes of NYS) is on strike and east of the discovery fields, and the southern boundary of the field area is about 8 km north of more recently discovered T/BR fields. Phase I, completed in 2004, consisted of integrating detailed outcrop fracture analyses with detailed soil gas analyses, lineaments, stratigraphy, seismic reflection data, well log data, and aeromagnetics. In the Seneca Lake region, Landsat lineaments (EarthSat, 1997) were coincident with fracture intensification domains (FIDs) and minor faults observed in outcrop and inferred from stratigraphy. Soil gas anomalies corresponded to ENE-trending lineaments and FIDs. N- and ENE-trending lineaments were parallel to aeromagnetic anomalies, whereas E-trending lineaments crossed aeromagnetic trends. 2-D seismic reflection data confirmed that the E-trending lineaments and FIDs occur where shallow level Alleghanian salt-cored thrust-faulted anticlines occur. In contrast, the ENE-trending FIDs and lineaments occur where Iapetan

  11. Bringing the field into the classroom: an innovative methodology in global health teaching

    OpenAIRE

    Dr. M H Bryant, MBBS; J Wolff, MD

    2015-01-01

    Background: The practice of global health is difficult to teach from a US-based classroom. Students benefit from experiencing how theory becomes practice in the chaotic environments of under-resourced health programmes in developing countries. We could not take our students to the field during weekly course work, so we designed a course to bring the field to the students. We created innovative partnerships with locally based organisations that implement programmes in developing countries. Eac...

  12. Innovation

    African Journals Online (AJOL)

    The purpose of Innovation journal of appropriate librarianship and information work in Southern Africa is to publish material on libraries, information supply and other related matters in South and Southern Africa. Vol 45 (2012). DOWNLOAD FULL TEXT Open Access DOWNLOAD FULL TEXT Subscription or Fee Access ...

  13. Innovation

    DEFF Research Database (Denmark)

    Torfing, Jacob; Ricard, Lykke Margot

    2017-01-01

    Innovation i krydsfeltet mellem forskellige styringsparadigmer i offentlige organisationer. New Public Governance gør det muligt at skabe offentlig værdi på nye måder. Men NPG er ingen trylledrik, der fra den ene dag til den anden skaber balance mellem borgernes store forventninger og en trængt ø...

  14. Co-design of RAD and ETHICS methodologies: a combination of information system development methods

    Science.gov (United States)

    Nasehi, Arezo; Shahriyari, Salman

    2011-12-01

    Co-design is a new trend in the social world which tries to capture different ideas in order to use the most appropriate features for a system. In this paper, co-design of two information system methodologies is regarded; rapid application development (RAD) and effective technical and human implementation of computer-based systems (ETHICS). We tried to consider the characteristics of these methodologies to see the possibility of having a co-design or combination of them for developing an information system. To reach this purpose, four different aspects of them are analyzed: social or technical approach, user participation and user involvement, job satisfaction, and overcoming change resistance. Finally, a case study using the quantitative method is analyzed in order to examine the possibility of co-design using these factors. The paper concludes that RAD and ETHICS are appropriate to be co-designed and brings some suggestions for the co-design.

  15. SELECTING WORKING TEAMS FOR INFORMATION TECHNOLOGY OUTSOURCING PROJECTS THROUGH A COMBINATION OF METHODOLOGIES

    Directory of Open Access Journals (Sweden)

    María Alejandra Castellini

    Full Text Available ABSTRACT This paper deals with a problem that Information Technology outsourcing suppliers generally face when selecting a working team technically capable for specific roles in software development projects. A combination of methodologies, interactively integrated, is proposed. They are Soft System Methodology to structure the problem, Repertory Grid for individual interviews and elicitation of the selection criteria, DRV Processes to assess the candidates and to generate knowledge and consensus on the selection process and Linear Programming to assign people to each position. This multimethodology allowed finding a more comprehensive solution than that initially requested by the company, since it helped to establish the necessary transformations for the selection model to operate in the right way, set the competencies to be considered as selection criteria, develop a consensus estimate of the weighted criteria, and award global values to candidates, optimizing the assignment of roles in the group for the project.

  16. Innovation

    OpenAIRE

    2012-01-01

    Présenté par FutuRIS, plate-forme prospective sur la recherche, l’innovation et la société animée par l’Association Nationale de la Recherche et de la Technologie, ce volume livre un panorama du système français de recherche et d’innovation dans son environnement européen. Sont abordés dans une première partie les champs décisionnels concernés, les politiques nationales menées en matière de R&D, les relations entre enseignement supérieur et recherche et l’Espace européen de la recherche à l’h...

  17. INNOVATION

    DEFF Research Database (Denmark)

    Helms, Niels Henrik

    2012-01-01

    Kravet om innovation og kreativitet er på flere måder en stor og en ny udfordring for voksenuddannelserne. Det udfordrer det didaktiske dilemma, det at vi skal gøres til kompetente og frie mennesker gennem pædagogiske handlinger, som netop pålægger os en ufrihed. – Men hvor denne ufrihed tidligere...... kunne begrundes med, at skolen eller uddannelsen vidste bedre, så er det ikke længere tilfældet. Skolen skal sørge for, at vi lærer noget – og ikke noget andet. Men det kan ikke længere med bestemthed afgøres, hvad det er vi skal lære i skolen, fordi det nye, det kreative og ikke mindst innovative...

  18. Barriers to using consumer science information in food technology innovations: An exploratory study using Delphi methodology

    Directory of Open Access Journals (Sweden)

    Marian E. Raley

    2016-04-01

    Full Text Available Food technology innovation has the potential to deliver many benefits to society, although some technologies have been problematic in terms of public acceptance. In promoting the commercial success of innovative technological processes and resultant products it will be important to incorporate information relating to consumer preferences and concerns during their development. The barriers to the utilisation of consumer information during technological development was explored using a two round Delphi study involving 75 experts with an interest in new food technology (food technologists and consumer scientists. There was overall agreement that consumer information should be used in technology implementation and product design, and that good communication between key actors at pivotal stages during the development of new food technologies and products was important. However disciplinary differences were perceived to be a barrier to communication, as were difficulties associated with producing consumer information usable by food technologists. A strategy to improve inter-disciplinary communication is proposed, involving the creation of multi-disciplinary teams working together throughout the development project’s duration, including those with interdisciplinary experience. Deficiencies in the specification of the information required from consumer scientists need to be overcome. Consumer science results need to be concrete and presented as salient to and usable by food technologists.

  19. An innovative methodology for the non-destructive diagnosis of architectural elements of ancient historical buildings.

    Science.gov (United States)

    Fais, Silvana; Casula, Giuseppe; Cuccuru, Francesco; Ligas, Paola; Bianchi, Maria Giovanna

    2018-03-12

    In the following we present a new non-invasive methodology aimed at the diagnosis of stone building materials used in historical buildings and architectural elements. This methodology consists of the integrated sequential application of in situ proximal sensing methodologies such as the 3D Terrestrial Laser Scanner for the 3D modelling of investigated objects together with laboratory and in situ non-invasive multi-techniques acoustic data, preceded by an accurate petrographical study of the investigated stone materials by optical and scanning electron microscopy. The increasing necessity to integrate different types of techniques in the safeguard of the Cultural Heritage is the result of the following two interdependent factors: 1) The diagnostic process on the building stone materials of monuments is increasingly focused on difficult targets in critical situations. In these cases, the diagnosis using only one type of non-invasive technique may not be sufficient to investigate the conservation status of the stone materials of the superficial and inner parts of the studied structures 2) Recent technological and scientific developments in the field of non-invasive diagnostic techniques for different types of materials favors and supports the acquisition, processing and interpretation of huge multidisciplinary datasets.

  20. A methodological combined framework for roadmapping biosensor research: a fault tree analysis approach within a strategic technology evaluation frame.

    Science.gov (United States)

    Siontorou, Christina G; Batzias, Fragiskos A

    2014-03-01

    Biosensor technology began in the 1960s to revolutionize instrumentation and measurement. Despite the glucose sensor market success that revolutionized medical diagnostics, and artificial pancreas promise currently the approval stage, the industry is reluctant to capitalize on other relevant university-produced knowledge and innovation. On the other hand, the scientific literature is extensive and persisting, while the number of university-hosted biosensor groups is growing. Considering the limited marketability of biosensors compared to the available research output, the biosensor field has been used by the present authors as a suitable paradigm for developing a methodological combined framework for "roadmapping" university research output in this discipline. This framework adopts the basic principles of the Analytic Hierarchy Process (AHP), replacing the lower level of technology alternatives with internal barriers (drawbacks, limitations, disadvantages), modeled through fault tree analysis (FTA) relying on fuzzy reasoning to count for uncertainty. The proposed methodology is validated retrospectively using ion selective field effect transistor (ISFET) - based biosensors as a case example, and then implemented prospectively membrane biosensors, putting an emphasis on the manufacturability issues. The analysis performed the trajectory of membrane platforms differently than the available market roadmaps that, considering the vast industrial experience in tailoring and handling crystallic forms, suggest the technology path of biomimetic and synthetic materials. The results presented herein indicate that future trajectories lie along with nanotechnology, and especially nanofabrication and nano-bioinformatics, and focused, more on the science-path, that is, on controlling the natural process of self-assembly and the thermodynamics of bioelement-lipid interaction. This retained the nature-derived sensitivity of the biosensor platform, pointing out the differences

  1. Applying a Living Lab methodology to support innovation in education at a university in South Africa

    Directory of Open Access Journals (Sweden)

    Ronel Callaghan

    2015-07-01

    Full Text Available The Living Lab paradigm creates open and inter-disciplinary environments where participants can interrogate challenges and co-create solutions. A successful Living Lab context incorporates a clear focus/vision, strong leadership, self-sustainability, a strong sense of community-owned challenges and the potential for sustainable community development. This paper discusses and outlines the elements of Living Labs, and how these have played a role in the establishment of a new Education Living Lab at a University in South Africa. Core values, stakeholders and key success factors of Living Labs are discussed. This is followed by the description of a case study of the establishment process of a Living Lab. The newly established Living Lab already shows success with collaborations and innovation between communities, industry, academia, learners and schools. This is illustrated in an application of the discussions on the Mobile Learning focus area - the first active sub-focus area within the Education Living Lab.

  2. RISK MANAGEMENT PROJECTS EVALUATION OF INNOVATION IN SMALL AND MEDIUM-HIGH TECHNOLOGY USING THE PERSPECTIVE OF PRISM METHODOLOGY

    Directory of Open Access Journals (Sweden)

    Taciana de Barros Jerônimo

    2011-10-01

    Full Text Available This study aims to analyze the failures of the activity of project management in small and medium-sized high-tech firms, using the tool PRISM. This postmortem methodology, proposed by Gary Pan, Shan L. and Ray Hackney Pan, analyzes the interactions between the components of the project during the exchange relationship between the project organization, information system and the users. Thus, the contribution of this work is to allow a formal analysis of the relationship between the sequence of events development projects into an innovative view, that provide insights into the potential success or failure of the project on medium-sized high-tech firms (whose the acronym is PMET.

  3. Linguistic & Rhetorical Paradigm as Innovative Theoretical Methodological Platform of Studying Discursive Processes of East Slavic and Western Cultures

    Directory of Open Access Journals (Sweden)

    Аlexandra A. Vorozhbitova

    2013-01-01

    Full Text Available The paper suggests studying conceptual models and mechanisms of linguistic consciousness of East Slavic and Western cultures with the application of the theoretical methodological approach of Linguistic & Rhetorical (L&R Paradigm as an integrative philological trend of an innovative type. The L&R Paradigm rests on the intersection of three categorical dimensions: ideological aspects of a speech event (ethos, logos, pathos; stages of universal cycle of idea-into-speech transformation (invention, disposition, elocution as a technology of discursive processes; levels of the structure of a linguistic personality as a discourse producer and ideology bearer (associative verbal network, thesaurus, pragmatic field. Hence, the article proposes three groups of L&R parameters of studying speech and thinking phenomena: ethos-motivational-dispositional; logos-thesaurus-inventional; pathos-verbal-elocutionary.

  4. A combined stochastic feedforward and feedback control design methodology with application to autoland design

    Science.gov (United States)

    Halyo, Nesim

    1987-01-01

    A combined stochastic feedforward and feedback control design methodology was developed. The objective of the feedforward control law is to track the commanded trajectory, whereas the feedback control law tries to maintain the plant state near the desired trajectory in the presence of disturbances and uncertainties about the plant. The feedforward control law design is formulated as a stochastic optimization problem and is embedded into the stochastic output feedback problem where the plant contains unstable and uncontrollable modes. An algorithm to compute the optimal feedforward is developed. In this approach, the use of error integral feedback, dynamic compensation, control rate command structures are an integral part of the methodology. An incremental implementation is recommended. Results on the eigenvalues of the implemented versus designed control laws are presented. The stochastic feedforward/feedback control methodology is used to design a digital automatic landing system for the ATOPS Research Vehicle, a Boeing 737-100 aircraft. The system control modes include localizer and glideslope capture and track, and flare to touchdown. Results of a detailed nonlinear simulation of the digital control laws, actuator systems, and aircraft aerodynamics are presented.

  5. Damage detection methodology on beam-like structures based on combined modal Wavelet Transform strategy

    Science.gov (United States)

    Serra, Roger; Lopez, Lautaro

    2018-05-01

    Different approaches on the detection of damages based on dynamic measurement of structures have appeared in the last decades. They were based, amongst others, on changes in natural frequencies, modal curvatures, strain energy or flexibility. Wavelet analysis has also been used to detect the abnormalities on modal shapes induced by damages. However the majority of previous work was made with non-corrupted by noise signals. Moreover, the damage influence for each mode shape was studied separately. This paper proposes a new methodology based on combined modal wavelet transform strategy to cope with noisy signals, while at the same time, able to extract the relevant information from each mode shape. The proposed methodology will be then compared with the most frequently used and wide-studied methods from the bibliography. To evaluate the performance of each method, their capacity to detect and localize damage will be analyzed in different cases. The comparison will be done by simulating the oscillations of a cantilever steel beam with and without defect as a numerical case. The proposed methodology proved to outperform classical methods in terms of noisy signals.

  6. Innovative didaktik

    DEFF Research Database (Denmark)

    Lund, Birthe

    Innovative didaktik. This deals with innovative didaktik from at methodological point of view in three ways - how to define the concept, how to develop it and how analyse it. Issues analysed: How to create innovative students? How to create innovative learning envoriments? These are core question...... in "Projekt Innovativ didaktik". The hidden curriculum is to inspire students to develop entreprenuership and creativty....

  7. INNOVATIVE SOLUTIONS IN BIOTECHNOLOGIES OF COMBINED YOGURT DRINKS WITH BALANCED CHEMICAL CONTENTS

    Directory of Open Access Journals (Sweden)

    N. A. Tkachenko

    2017-10-01

    Full Text Available Expediency of development of recipes and innovative biotechnologies for combined milk-vegetational products with balanced chemical composition, strengthened probiotic properties and extended shelf life was proven in field of establishing proper diet for adult healthy people, both in everyday consumption and during treatment of illnesses and rehabilitation after it. Principles of scientific approach to creation of biotechnologies for fermented combined products with balance of basic food nutrients are described here, as well as innovative biotechnological approaches, which provide the possibility of getting desired products (yoghurt drinks with high probiotic properties and long shelf life. Main stages of development are described for recipes and biotechnologies of bifido-enabled combined yoghurt drinks with balanced chemical composition, rich on lively bifido- and Lactobacterium cells and long shelf life. A scheme for production of desired products with explanation of technological process parameters is provided, it was tested in industrial conditions at “Gormolzavod №1” Ltd. in Odesa, Ukraine. In samples of milk-rice and milk-spelt yoghurt drinks, which were produced in industrial conditions, we determined chemical composition and primary quality objectives. Desired products have balanced ratio of proteins : fats : carbohydrates (1 : 1 : 4, high sensory qualities, standard quality values during long shelf life (20 days in sealed tare, contain a high concentration of viable cells of probiotic cultures – such as B. animalis Bb-12 (not less than 3.6∙108 CFU / cm3 and mixed cultures of L. bulgaricus + S. thermophilus (not less than 4.0∙108 CFU/cm3, as well as physiologically significant number of prebiotics – lactulose and fiber (30 and 10%, according to the daily consumption norm when consuming 500 cm3 of product.

  8. Final Report, Nuclear Energy Research Initiative (NERI) Project: An Innovative Reactor Analysis Methodology Based on a Quasidiffusion Nodal Core Model

    International Nuclear Information System (INIS)

    Anistratov, Dmitriy Y.; Adams, Marvin L.; Palmer, Todd S.; Smith, Kord S.; Clarno, Kevin; Hikaru Hiruta; Razvan Nes

    2003-01-01

    OAK (B204) Final Report, NERI Project: ''An Innovative Reactor Analysis Methodology Based on a Quasidiffusion Nodal Core Model'' The present generation of reactor analysis methods uses few-group nodal diffusion approximations to calculate full-core eigenvalues and power distributions. The cross sections, diffusion coefficients, and discontinuity factors (collectively called ''group constants'') in the nodal diffusion equations are parameterized as functions of many variables, ranging from the obvious (temperature, boron concentration, etc.) to the more obscure (spectral index, moderator temperature history, etc.). These group constants, and their variations as functions of the many variables, are calculated by assembly-level transport codes. The current methodology has two main weaknesses that this project addressed. The first weakness is the diffusion approximation in the full-core calculation; this can be significantly inaccurate at interfaces between different assemblies. This project used the nodal diffusion framework to implement nodal quasidiffusion equations, which can capture transport effects to an arbitrary degree of accuracy. The second weakness is in the parameterization of the group constants; current models do not always perform well, especially at interfaces between unlike assemblies. The project developed a theoretical foundation for parameterization and homogenization models and used that theory to devise improved models. The new models were extended to tabulate information that the nodal quasidiffusion equations can use to capture transport effects in full-core calculations

  9. A new combined wavelet methodology: implementation to GPR and ERT data obtained in the Montagnole experiment

    International Nuclear Information System (INIS)

    Alperovich, L; Eppelbaum, L; Zheludev, V; Dumoulin, J; Soldovieri, F; Proto, M; Bavusi, M; Loperte, A

    2013-01-01

    Ground penetrating radar (GPR) and electric resistivity tomography (ERT) are well assessed and accurate geophysical methods for the investigation of subsurface geological sections. In this paper, we present the joint exploitation of these methods at the Montagnole (French Alps) experimental site with the final aim to study and monitor effects of possible catastrophic rockslides in transport infrastructures. The overall goal of the joint GPR–ERT deployment considered here is the careful monitoring of the subsurface structure before and after a series of high energetic mechanical impacts at ground level. It is known that factors such as the ambiguity of geophysical field examination, the complexity of geological scenarios and the low signal-to-noise ratio affect the possibility of building reliable physical–geological models of subsurface structure. Here, we applied to the GPR and ERT methods at the Montagnole site, recent advances in wavelet theory and data mining. The wavelet approach was specifically used to obtain enhanced images (e.g. coherence portraits) resulting from the integration of the different geophysical fields. This methodology, based on the matching pursuit combined with wavelet packet dictionaries, permitted us to extract desired signals under different physical–geological conditions, even in the presence of strongly noised data. Tools such as complex wavelets employed for the coherence portraits, and combined GPR–ERT coherency orientation angle, to name a few, enable non-conventional operations of integration and correlation in subsurface geophysics to be performed. The estimation of the above-mentioned parameters proved useful not only for location of buried inhomogeneities but also for a rough estimation of their electromagnetic and related properties. Therefore, the combination of the above approaches has allowed us to set up a novel methodology, which may enhance the reliability and confidence of each separate geophysical method and

  10. First results of the research project MIRAMAR, Innovative Methodologies for Coastal Environmental Monitoring and Analysis

    Science.gov (United States)

    Rovere, A.; Casella, E.; Vacchi, M.; Mucerino, L.; Pedroncini, A.; Ferrari, M.; Firpo, M.

    2013-12-01

    A large part of the Mediterranean coastlines are strongly affected by coastal erosion. This is mainly due to human impact, natural hazards and their mutual interaction. All along the Regione Liguria coastlines (Northwestern Mediterranean), significant problems of coastal erosion are reported since the '60s. In this study, we focus on the coastal area between Albenga and Savona, where dramatic coastal retreat of ~2 m y-1 has been inferred from comparison of historic maps and older aerial pictures. Beach monitoring is essential in order to understand the mechanisms of evolution of soft coasts, and the rates of erosion. Traditional beach monitoring techniques involve topographic and bathymetric surveys of the emerged and submerged beach, and/or aerial photos repeated in time and compared through geographical information systems. A major problem of this kind of approach is the high economic cost. This often leads to increase the time lag between successive monitoring campaigns to reduce survey costs, with the consequence of fragmenting the information available for coastal zone management. MIRAMar is a project funded by Regione Liguria through the PO CRO European Social Fund, and it has two main objectives: i) to study and develop an innovative technique, relatively low-cost, to monitor the evolution of the shoreline using low-altitude Unmanned Aerial Vehicle (UAV) photos; ii) to study the impact of different type of storm events on a vulnerable coastal tract subject to coastal erosion using also the data collected by the UAV instrument. To achieve these aims we use a drone with its hardware and software suit, traditional survey techniques (bathymetric surveys, topographic GPS surveys and GIS techniques) and we implement a numerical modeling chain (coupling hydrodynamic, wave and sand transport modules) in order to study the impact of different type of storm events on a vulnerable coastal tract subject to coastal erosion. Aerial picture of one of the beaches studied

  11. Innovation

    African Journals Online (AJOL)

    Natal, South Africa are presented in this article. Of particular interest is how the combination of adult and early literacy activities has encouraged reading in families. The evaluative process involved individual qualitative interviews, material review ...

  12. Construction schedule delay risk assessment by using combined AHP-RII methodology for an international NPP project

    Directory of Open Access Journals (Sweden)

    Muhammed Mufazzal Hossen

    2015-04-01

    The proposed combined AHP-RII methodology is capable of assessing delay risk effectively and efficiently. Decision makers can apply risk informed decision making to avoid unexpected construction delays of NPPs.

  13. License and entry strategies for an outside innovator under duopoly with combination of royalty and fixed fee

    OpenAIRE

    Hattori, Masahiko; Tanaka, Yasuhito

    2017-01-01

    We consider a choice of options for an innovating firm to enter the market with or without licensing its new cost-reducing technology to the incumbent firm using a combination of a royalty per output and a fixed license fee, or to license its technology without entry. With general demand and cost functions we show the following results. When the innovating firm licenses its technology to the incumbent firm without entry, the optimal royalty rate per output for the innovating firm is zero with...

  14. License and entry strategies for an outside innovator in duopoly with combination of royalty and fixed fee under vertical differentiation

    OpenAIRE

    Hattori, Masahiko; Tanaka, Yasuhito

    2017-01-01

    We consider a choice of options for an innovating firm in duopoly under vertical differentiation to enter the market with or without licensing its technology for producing a higher quality good to the incumbent firm using a combination of a royalty per output and a fixed license fee, or to license its technology without entry. With general distribution function of consumers' taste parameter and cost function we will show that when the innovating firm licenses its technology to the incumbent f...

  15. Innovation In Music

    OpenAIRE

    2014-01-01

    The music industry is a fast moving field with new technology and methodological advances combining to catalyse innovations all the time. 'Innovation in Music 2013' was an international conference exploring this topic, held in December 2013 in York, Uk. The event covered specific and cross-disciplinary aspects of the music industry including music creation, technology, production and business, sound engineering, mastering, post production and sound design, games music and cross-disciplinary t...

  16. Preliminary seismic analysis of an innovative near term reactor: Methodology and application

    International Nuclear Information System (INIS)

    Lo Frano, R.; Pugliese, G.; Forasassi, G.

    2010-01-01

    Nuclear power plant (NPP) design is strictly dependent on seismic hazard and safety aspects concerned with the external events of the site. Earthquake resistant structures design requires realistic and accurate physical and theoretical models to describe the response of the nuclear power plants (NPPs) that depend on both the ground motion characteristics and the dynamic properties of the structures themselves. In order to improve the design of new NPPs and, at the same time, to retrofit existing ones the dynamic behaviour of structures subjected to critical seismic excitations that may occur during their expected service life must be evaluated. The aim of this work is to select new effective methods to assess NPPs vulnerability by properly capturing the effects of a safe shutdown earthquake (SSE) event on nuclear structures, like the near term deployment IRIS reactor, and to evaluate the seismic resistance capability of as-built structures systems and components. To attain the purpose a validated deterministic methodology based on an accurate finite element modelling coupled to substructure and time history approaches was employed for studying the overall dynamic behaviour of the NPP relevant components. Moreover the set up three-dimensional model was also validated to evaluate the performance and reliability of the adopted FEM code (mesh refinements and type element influence). This detailed numerical assessment, involving the most widely used finite element numerical codes (MSC.Marc and Ansys, allowed to solve, perform and simulate as accurately as possible the dynamic behaviour of structures which may withstand a lot of more or less complicate structural problems. To evaluate the accuracy and the reliability as well as to determine the related error of the set-up procedure, the obtained seismic analyses results in term of accelerations, propagated from the ground to the auxiliary building systems and components, and displacements were compared highlighting a

  17. Metodologicheskie osobennosti upravlenija stoimost'ju kompanii, osushhestvljajushhej «zelenye» innovacii [The methodological features of managing the value of companies introducing "green" innovations

    Directory of Open Access Journals (Sweden)

    Kharin Alexander

    2012-01-01

    Full Text Available Although it is a common assumption that innovations are one of the most important factors of economic development, there is a need to review some provisions of innovation methodology so that new fundamental values are taken into account more fully. Most recent business models are based on the depletion of natural environment, whose potential has been almost exhausted. It is necessary to introduce new ideas that are of use for society and create values for companies. One way of achieving this goal is “green” (environmental innovations. The next decade is expected to see a rapid growth in environmental innovations. Their organization and management will require modern — and adequate to the objectives set —technologies. One of those is the quest for value methodology. To date, the quest for value methodology has given rise to several conceptual approaches, which can be used to evaluate the effectiveness of environmental innovations. This article discusses the advantages and disadvantages of major approaches. The author comes to a conclusion that that the modern theory and practice of corporate finance still lacks a generally accepted approach to assessing the value of companies that explicitly takes into account the impact of environmental factors on the cost. The article outlines the basic theoretical frameworks for the formation of such approach.

  18. Everyday-Oriented Innovation

    DEFF Research Database (Denmark)

    Munnecke, Max

    The exploration of radical innovation has long been regarded as fundamental to business growth. In the 21st century, modern organisations increasingly seek to combine business innovation with the broader goal to confront social and environmental challenges. Vision projects are related phenomena...... which explore and map radical innovation opportunities within everyday activities. The aim of a vision project is to produce an innovation map that can empower an organisation to navigate between potential innovation opportunities and pro‐actively confront modern challenges for the benefit of people......, business, and society. The study addresses the concern that vision projects do not produce sufficient navigational innovation maps, and seeks to improve their quality by modelling a new methodological framework. The study was conducted as a series of four research cycles which modelled and experimented...

  19. Innovative Methodologies for thermal Energy Release Measurement: case of La Solfatara volcano (Italy)

    Science.gov (United States)

    Marfe`, Barbara; Avino, Rosario; Belviso, Pasquale; Caliro, Stefano; Carandente, Antonio; Marotta, Enrica; Peluso, Rosario

    2015-04-01

    This work is devoted to improve the knowledge on the parameters that control the heat flux anomalies associated with the diffuse degassing processes of volcanic and hydrothermal areas. The methodologies currently used to measure heat flux (i.e. CO2 flux or temperature gradient) are either poorly efficient or effective, and are unable to detect short to medium time (days to months) variation trends in the heat flux. A new method, based on the use of thermal imaging cameras, has been applied to estimate the heat flux and its time variations. This approach will allow faster heat flux measurement than already accredited methods, improving in this way the definition of the activity state of a volcano and allowing a better assessment of the related hazard and risk mitigation. The idea is to extrapolate the heat flux from the ground surface temperature that, in a purely conductive regime, is directly correlated to the shallow temperature gradient. We use thermal imaging cameras, at short distances (meters to hundreds of meters), to quickly obtain a mapping of areas with thermal anomalies and a measure of their temperature. Preliminary studies have been carried out throughout the whole of the La Solfatara crater in order to investigate a possible correlation between the surface temperature and the shallow thermal gradient. We have used a FLIR SC640 thermal camera and K type thermocouples to assess the two measurements at the same time. Results suggest a good correlation between the shallow temperature gradient ΔTs and the surface temperature Ts depurated from background, and despite the campaigns took place during a period of time of a few years, this correlation seems to be stable over the time. This is an extremely motivating result for a further development of a measurement method based only on the use of small range thermal imaging camera. Surveys with thermal cameras may be manually done using a tripod to take thermal images of small contiguous areas and then joining

  20. Innovative Methodologies for 21st Century Learning, Teaching and Assessment: A Convenience Sampling Investigation into the Use of Social Media Technologies in Higher Education

    Science.gov (United States)

    Kivunja, Charles

    2015-01-01

    The advent of the Web as a social technology has created opportunities for the creation of informal learning environments, which have potential for innovative methodologies in learning, teaching and assessment. However, as Wolfe (2001) admonishes, "contrary to the rhetoric of cheerleaders, the Web places greater demands on students than…

  1. MIMIC: An Innovative Methodology for Determining Mobile Laser Scanning System Point Density

    Directory of Open Access Journals (Sweden)

    Conor Cahalane

    2014-08-01

    Full Text Available Understanding how various Mobile Mapping System (MMS laser hardware configurations and operating parameters exercise different influence on point density is important for assessing system performance, which in turn facilitates system design and MMS benchmarking. Point density also influences data processing, as objects that can be recognised using automated algorithms generally require a minimum point density. Although obtaining the necessary point density impacts on hardware costs, survey time and data storage requirements, a method for accurately and rapidly assessing MMS performance is lacking for generic MMSs. We have developed a method for quantifying point clouds collected by an MMS with respect to known objects at specified distances using 3D surface normals, 2D geometric formulae and line drawing algorithms. These algorithms were combined in a system called the Mobile Mapping Point Density Calculator (MIMIC and were validated using point clouds captured by both a single scanner and a dual scanner MMS. Results from MIMIC were promising: when considering the number of scan profiles striking the target, the average error equated to less than 1 point per scan profile. These tests highlight that MIMIC is capable of accurately calculating point density for both single and dual scanner MMSs.

  2. Computer Class Role Playing Games, an innovative teaching methodology based on STEM and ICT: first experimental results

    Science.gov (United States)

    Maraffi, S.

    2016-12-01

    Context/PurposeWe experienced a new teaching and learning technology: a Computer Class Role Playing Game (RPG) to perform educational activity in classrooms through an interactive game. This approach is new, there are some experiences on educational games, but mainly individual and not class-based. Gaming all together in a class, with a single scope for the whole class, it enhances peer collaboration, cooperative problem solving and friendship. MethodsTo perform the research we experimented the games in several classes of different degrees, acquiring specific questionnaire by teachers and pupils. Results Experimental results were outstanding: RPG, our interactive activity, exceed by 50% the overall satisfaction compared to traditional lessons or Power Point supported teaching. InterpretationThe appreciation of RPG was in agreement with the class level outcome identified by the teacher after the experimentation. Our work experience get excellent feedbacks by teachers, in terms of efficacy of this new teaching methodology and of achieved results. Using new methodology more close to the student point of view improves the innovation and creative capacities of learners, and it support the new role of teacher as learners' "coach". ConclusionThis paper presents the first experimental results on the application of this new technology based on a Computer game which project on a wall in the class an adventure lived by the students. The plots of the actual adventures are designed for deeper learning of Science, Technology, Engineering, Mathematics (STEM) and Social Sciences & Humanities (SSH). The participation of the pupils it's based on the interaction with the game by the use of their own tablets or smartphones. The game is based on a mixed reality learning environment, giving the students the feel "to be IN the adventure".

  3. The Combined ASTER MODIS Emissivity over Land (CAMEL Part 1: Methodology and High Spectral Resolution Application

    Directory of Open Access Journals (Sweden)

    E. Eva Borbas

    2018-04-01

    Full Text Available As part of a National Aeronautics and Space Administration (NASA MEaSUREs (Making Earth System Data Records for Use in Research Environments Land Surface Temperature and Emissivity project, the Space Science and Engineering Center (UW-Madison and the NASA Jet Propulsion Laboratory (JPL developed a global monthly mean emissivity Earth System Data Record (ESDR. This new Combined ASTER (Advanced Spaceborne Thermal Emission and Reflection Radiometer and MODIS (Moderate Resolution Imaging Spectroradiometer Emissivity over Land (CAMEL ESDR was produced by merging two current state-of-the-art emissivity datasets: the UW-Madison MODIS Infrared emissivity dataset (UW BF and the JPL ASTER Global Emissivity Dataset Version 4 (GEDv4. The dataset includes monthly global records of emissivity and related uncertainties at 13 hinge points between 3.6–14.3 µm, as well as principal component analysis (PCA coefficients at 5-km resolution for the years 2000 through 2016. A high spectral resolution (HSR algorithm is provided for HSR applications. This paper describes the 13 hinge-points combination methodology and the high spectral resolutions algorithm, as well as reports the current status of the dataset.

  4. Combined methodology for estimating dose rates and health effects from exposure to radioactive pollutants

    Energy Technology Data Exchange (ETDEWEB)

    Dunning, D.E. Jr.; Leggett, R.W.; Yalcintas, M.G.

    1980-12-01

    The work described in the report is basically a synthesis of two previously existing computer codes: INREM II, developed at the Oak Ridge National Laboratory (ORNL); and CAIRD, developed by the Environmental Protection Agency (EPA). The INREM II code uses contemporary dosimetric methods to estimate doses to specified reference organs due to inhalation or ingestion of a radionuclide. The CAIRD code employs actuarial life tables to account for competing risks in estimating numbers of health effects resulting from exposure of a cohort to some incremental risk. The combined computer code, referred to as RADRISK, estimates numbers of health effects in a hypothetical cohort of 100,000 persons due to continuous lifetime inhalation or ingestion of a radionuclide. Also briefly discussed in this report is a method of estimating numbers of health effects in a hypothetical cohort due to continuous lifetime exposure to external radiation. This method employs the CAIRD methodology together with dose conversion factors generated by the computer code DOSFACTER, developed at ORNL; these dose conversion factors are used to estimate dose rates to persons due to radionuclides in the air or on the ground surface. The combination of the life table and dosimetric guidelines for the release of radioactive pollutants to the atmosphere, as required by the Clean Air Act Amendments of 1977.

  5. Continuing harmonization of terminology and innovations for methodologies in developmental toxicology: Report of the 8th Berlin Workshop on Developmental Toxicity, 14-16 May 2014.

    Science.gov (United States)

    Solecki, Roland; Rauch, Martina; Gall, Andrea; Buschmann, Jochen; Clark, Ruth; Fuchs, Antje; Kan, Haidong; Heinrich, Verena; Kellner, Rupert; Knudsen, Thomas B; Li, Weihua; Makris, Susan L; Ooshima, Yojiro; Paumgartten, Francisco; Piersma, Aldert H; Schönfelder, Gilbert; Oelgeschläger, Michael; Schaefer, Christof; Shiota, Kohei; Ulbrich, Beate; Ding, Xuncheng; Chahoud, Ibrahim

    2015-11-01

    This article is a report of the 8th Berlin Workshop on Developmental Toxicity held in May 2014. The main aim of the workshop was the continuing harmonization of terminology and innovations for methodologies used in the assessment of embryo- and fetotoxic findings. The following main topics were discussed: harmonized categorization of external, skeletal, visceral and materno-fetal findings into malformations, variations and grey zone anomalies, aspects of developmental anomalies in humans and laboratory animals, and innovations for new methodologies in developmental toxicology. The application of Version 2 terminology in the DevTox database was considered as a useful improvement in the categorization of developmental anomalies. Participants concluded that initiation of a project for comparative assessments of developmental anomalies in humans and laboratory animals could support regulatory risk assessment and university-based training. Improvement of new methodological approaches for alternatives to animal testing should be triggered for a better understanding of developmental outcomes. Copyright © 2015. Published by Elsevier Inc.

  6. Combined enzymatic and physical deinking methodology for efficient eco-friendly recycling of old newsprint.

    Directory of Open Access Journals (Sweden)

    Antar Puneet Virk

    Full Text Available BACKGROUND: The development in the deinking process has made recycled fiber a major part of the raw material for pulp and paper industry. Enzymes have revolutionized the deinking process obtaining brightness levels surpassing conventional deinking processes. This study explores the deinking efficiencies of bacterial alkalophilic laccase (L and xylanase (X enzymes along with physical deinking methods of microwaving (MW and sonication (S for recycling of old newsprint (ONP. METHODS AND RESULTS: The operational parameters viz. enzyme dose, pH and treatment time for X and L deinking were optimized statistically using Response Surface Methodology. Laccase did not require any mediator supplementation for deinking. Deinking of ONP pulp with a combination of xylanase and laccase enzymes was investigated, and fiber surface composition and morphological changes were studied using X-ray diffraction, fourier transform infrared spectroscopy and scanning electron microscopy. Compared to the pulp deinked with xylanase (47.9% or laccase (62.2% individually, the percentage reduction of effective residual ink concentration (ERIC was higher for the combined xylanase/laccase-deinked pulp (65.8%. An increase in brightness (21.6%, breaking length (16.5%, burst factor (4.2% tear factor (6.9%, viscosity (13% and cellulose crystallinity (10.3% along with decrease in kappa number (22% and chemical consumption (50% were also observed. Surface appeared more fibrillar along with changes in surface functional groups. A combination of physical and enzymatic processes (S-MW-XL for deinking further improved brightness (28.8% and decreased ERIC (73.9% substantially. CONCLUSION: This is the first report on deinking of ONP with laccase without any mediator supplementation. XL pretreatment resulted in marked improvement in paper quality and a new sequence being reported for deinking (S-MW-XL will contribute further in decreasing chemical consumption and making the process

  7. Innovation in healthcare services – creating a Combined Contingency Theory and Ecosystems Approach

    Science.gov (United States)

    Engelseth, Per; Kritchanchai, Duangpun

    2018-04-01

    The purpose of this conceptual paper is to develop an analytical framework used for process development in healthcare services. Healthcare services imply a form of operations management demanding an adapted research approach. This study therefore highlights first in the introduction challenges of healthcare services as a reasoning of this study. It is a type of service that has high societal and therefore ethical concern, but at the same time needs to be carried out efficiently to economise service production resource use. Combined business and ethics concerns need to be balanced in this service supply system. In the literature review that is the bulk of this paper, first, particularities of the service industry processes are considered. This is followed by considering literature on contingency theory to consider the nature of the supply chain context of the healthcare service processes highlighting interdependencies and appropriate technology use. This developed view is then expanded to consider an ecosystems approach to encompass the environment expanding analyses to considering in balanced manner features of business, society and nature. A research model for directing both further researches on the healthcare service industry an innovation of such services in practice is introduced.

  8. A combined reaction class approach with integrated molecular orbital+molecular orbital (IMOMO) methodology: A practical tool for kinetic modeling

    International Nuclear Information System (INIS)

    Truong, Thanh N.; Maity, Dilip K.; Truong, Thanh-Thai T.

    2000-01-01

    We present a new practical computational methodology for predicting thermal rate constants of reactions involving large molecules or a large number of elementary reactions in the same class. This methodology combines the integrated molecular orbital+molecular orbital (IMOMO) approach with our recently proposed reaction class models for tunneling. With the new methodology, we show that it is possible to significantly reduce the computational cost by several orders of magnitude while compromising the accuracy in the predicted rate constants by less than 40% over a wide range of temperatures. Another important result is that the computational cost increases only slightly as the system size increases. (c) 2000 American Institute of Physics

  9. Combined methodology of optimization and life cycle inventory for a biomass gasification based BCHP system

    International Nuclear Information System (INIS)

    Wang, Jiang-Jiang; Yang, Kun; Xu, Zi-Long; Fu, Chao; Li, Li; Zhou, Zun-Kai

    2014-01-01

    Biomass gasification based building cooling, heating, and power (BCHP) system is an effective distributed energy system to improve the utilization of biomass resources. This paper proposes a combined methodology of optimization method and life cycle inventory (LCI) for the biomass gasification based BCHP system. The life cycle models including biomass planting, biomass collection-storage-transportation, BCHP plant construction and operation, and BCHP plant demolition and recycle, are constructed to obtain economic cost, energy consumption and CO 2 emission in the whole service-life. Then, the optimization model for the biomass BCHP system including variables, objective function and solution method are presented. Finally, a biomass BCHP case in Harbin, China, is optimized under different optimization objectives, the life-cycle performances including cost, energy and CO 2 emission are obtained and the grey incidence approach is employed to evaluate their comprehensive performances of the biomass BCHP schemes. The results indicate that the life-cycle cost, energy efficiency and CO 2 emission of the biomass BCHP system are about 41.9 $ MWh −1 , 41% and 59.60 kg MWh −1 respectively. The optimized biomass BCHP configuration to minimize the life-cycle cost is the best scheme to achieve comprehensive benefit including cost, energy consumption, renewable energy ratio, steel consumption, and CO 2 emission. - Highlights: • Propose the combined method of optimization and LCI for biomass BCHP system. • Optimize the biomass BCHP system to minimize the life-cycle cost, energy and emission. • Obtain the optimized life-cycle cost, energy efficiency and CO 2 emission. • Select the best biomass BCHP scheme using grey incidence approach

  10. Combining nutrition and exercise to optimize survival and recovery from critical illness: Conceptual and methodological issues.

    Science.gov (United States)

    Heyland, Daren K; Stapleton, Renee D; Mourtzakis, Marina; Hough, Catherine L; Morris, Peter; Deutz, Nicolaas E; Colantuoni, Elizabeth; Day, Andrew; Prado, Carla M; Needham, Dale M

    2016-10-01

    Survivors of critical illness commonly experience neuromuscular abnormalities, including muscle weakness known as ICU-acquired weakness (ICU-AW). ICU-AW is associated with delayed weaning from mechanical ventilation, extended ICU and hospital stays, more healthcare-related hospital costs, a higher risk of death, and impaired physical functioning and quality of life in the months after ICU admission. These observations speak to the importance of developing new strategies to aid in the physical recovery of acute respiratory failure patients. We posit that to maintain optimal muscle mass, strength and physical function, the combination of nutrition and exercise may have the greatest impact on physical recovery of survivors of critical illness. Randomized trials testing this and related hypotheses are needed. We discussed key methodological issues and proposed a common evaluation framework to stimulate work in this area and standardize our approach to outcome assessments across future studies. Copyright © 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

  11. Hospital innovation portfolios: Key determinants of size and innovativeness

    DEFF Research Database (Denmark)

    Schultz, Carsten; Zippel-Schultz, Bettina; Salomo, Søren

    2012-01-01

    and reward systems) organizational mechanisms. Methodology: To develop hypotheses, we integrated the innovation management literature into the hospital context. Detailed information about the innovation portfolio of 87 German hospitals was generated and combined with multirespondent survey data using ratings....... Reward systems did not have direct effects on the composition of innovation portfolios. However, they adjusted bottom-up employee and top-down strategic initiatives to match with the existing organization, thereby decreasing the degree of innovativeness and enforcing exploitation. Practice Implications......: Hospitals should intertwine employee encouragement, analytical approaches, and formal reward systems depending on organizational goals....

  12. Songbird - AN Innovative Uas Combining the Advantages of Fixed Wing and Multi Rotor Uas

    Science.gov (United States)

    Thamm, F.-P.; Brieger, N.; Neitzke, K.-P.; Meyer, M.; Jansen, R.; Mönninghof, M.

    2015-08-01

    This paper describes a family of innovative fixed wing UAS with can vertical take off and land - the SONGBIRD family. With nominal payloads starting from 0.5 kg they can take off and land safely like a multi-rotor UAV, removing the need for an airstrip for the critical phases of operation. A specially designed flight controller allows stable flight at every point of the transition phase between VTOL and fixed wing mode. Because of this smooth process with a all time stable flight, very expensive payload like hyperspectral sensors or advanced optical cameras can be used. Due to their design all airplanes of the SONGBIRD family have excellent horizontal flight properties, a maximum speed of over 110 km/h, good gliding properties and long flight times of up to 1 h. Missions were flown in wind speeds up to 18 m/s. At every time of the flight it is possible to interrupt the mission and hover over a point of interest for detail investigations. The complete flight, including take-off and landing can be performed by autopilot. Designed for daily use in professional environments, SONGBIRDs are built out of glass-fibre and carbon composites for a long service life. For safe operations comprehensive security features are implemented, for example redundant flight controllers and sensors, advanced power management system and mature fail safe procedures. The aircraft can be dismantled into small parts for transportation. SONGBIRDS are available for different pay loads, from 500 g to 2 kg. The SONGBIRD family are interesting tools combining the advantages of multi-copter and fixed wing UAS.

  13. What can triple helix frameworks offer to the analysis of eco-innovation dynamics? Theoretical and methodological considerations

    DEFF Research Database (Denmark)

    Yang, Yan; Holgaard, Jette Egelund; Remmen, Arne

    2012-01-01

    stakeholder groups are interacting in this connection. Taking the triple helix as the theoretical departure point, this paper discusses the opportunities offered by these triple helix frameworks for analyzing eco-innovation dynamics from both theoretical and practical perspectives. It adds to the debate about......Bringing environmental concerns into focus of innovation processes will in several cases also expand the numbers of actors involved. Eco-innovation and triple helix are often frameworks applied to analyse how environmental concerns are integrated in the innovation processes and how different...

  14. A combined wear-fatigue design methodology for fretting in the pressure armour layer of flexible marine risers

    OpenAIRE

    O'Halloran, S.M.; Shipway, P.H.; Connaire, A.D.; Leen, Sean B.; Harte, A.M.

    2017-01-01

    This paper presents a combined experimental and computational methodology for fretting wear-fatigue prediction of pressure armour wire in flexible marine risers. Fretting wear, friction and fatigue parameters of pressure armour material have been characterised experimentally. A combined fretting wear-fatigue finite element model has been developed using an adaptive meshing technique and the effect of bending-induced tangential slip has been characterised. It has been shown that a surface dama...

  15. Onto-clust--a methodology for combining clustering analysis and ontological methods for identifying groups of comorbidities for developmental disorders.

    Science.gov (United States)

    Peleg, Mor; Asbeh, Nuaman; Kuflik, Tsvi; Schertz, Mitchell

    2009-02-01

    Children with developmental disorders usually exhibit multiple developmental problems (comorbidities). Hence, such diagnosis needs to revolve on developmental disorder groups. Our objective is to systematically identify developmental disorder groups and represent them in an ontology. We developed a methodology that combines two methods (1) a literature-based ontology that we created, which represents developmental disorders and potential developmental disorder groups, and (2) clustering for detecting comorbid developmental disorders in patient data. The ontology is used to interpret and improve clustering results and the clustering results are used to validate the ontology and suggest directions for its development. We evaluated our methodology by applying it to data of 1175 patients from a child development clinic. We demonstrated that the ontology improves clustering results, bringing them closer to an expert generated gold-standard. We have shown that our methodology successfully combines an ontology with a clustering method to support systematic identification and representation of developmental disorder groups.

  16. Combining Project-Based Learning and Community-Based Research in a Research Methodology Course: The Lessons Learned

    Science.gov (United States)

    Arantes do Amaral, João Alberto; Lino dos Santos, Rebeca Júlia Rodrigues

    2018-01-01

    In this article, we present our findings regarding the course "Research Methodology," offered to 22 first-year undergraduate students studying Administration at the Federal University of São Paulo, Osasco, Brazil. The course, which combined community-based research and project-based learning, was developed during the second semester of…

  17. How to combine human resource management systems and human capital portfolios to achieve superior innovation performance

    OpenAIRE

    Rupietta, Christian; Backes-Gellner, Uschi

    2013-01-01

    Firms generate new knowledge that leads to innovations by recombining existing knowledge sources. A successful recombination depends on both the availability of a knowledge stock (human capital pool) that contains innovation-relevant knowledge and the regulation of the knowledge flow through the application of human resource management practices. However, while human resource theory expects complementarities between both the human capital pool and the human resource management system it does ...

  18. Introduction to the use of the INPRO methodology in a nuclear energy system assessment. A report of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO)

    International Nuclear Information System (INIS)

    2010-01-01

    The International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) was initiated in 2001 on the basis of an IAEA General Conference resolution in 2000 (GC(44)/RES/21). INPRO activities have since that time been continuously endorsed by resolutions of the IAEA General Conference and by the General Assembly of the United Nations. The objectives of INPRO are to: Help ensure that nuclear energy is available to contribute, in a sustainable manner, to the goal of meeting energy needs in the 21st century; Bring together technology holders and users so that they can jointly consider the international and national actions required to ensure the sustainability of nuclear energy through innovations in technology and/or institutional arrangements. To fulfil these objectives, INPRO developed a set of basic principles, user requirements and criteria, along with an assessment method, which are the basis of the INPRO methodology for evaluation of the sustainability of innovative nuclear energy systems. To provide additional guidance in using the INPRO methodology, the nine volume INPRO Manual was developed; it consists of an overview volume and eight volumes covering the areas of economics, institutional measures (infrastructure), waste management, proliferation resistance, physical protection, environment (including the impact of stressors and the availability of resources), reactor safety, and the safety of nuclear fuel cycle facilities. To assist Member States in applying the INPRO methodology, the nuclear energy system assessment (NESA) support package is being developed. This includes a database (containing input data for assessment), provision of training courses in the INPRO methodology and examples of comprehensive assessments. This publication provides guidance on how a variety of potential users, including nuclear technology developers, experienced users and prospective first time nuclear technology users (newcomers) can apply the INPRO methodology for

  19. The Methodological Foundations of the Economic Evaluation of the Level of Intensification of the Innovative Processes at Industrial Enterprise in the Part of Technical-Technological Subsystem

    Directory of Open Access Journals (Sweden)

    Plakhotnik Olena О.

    2017-04-01

    Full Text Available Regularities of technocratic changes define the change of technological methods of production and technological modes at the level of the stages of development of a production enterprise. An important role occupies the commercialization of technical-technological innovation. The article allocates the directions of impact on commodity markets and the production enterprises, which are operating there. It is using the exclusive rights tool will meet the challenges of changes in the structure of the national economy so as to increase the level of its competitiveness on the world market. The article proposes the improved methodological approach to forming a system of analytical indicators for evaluating the economic efficiency of the level of intensification of the technical-technological innovation processes at industrial enterprise, based on reasonable conditions and factors of innovation development of industrial enterprise, models of quantitative measuring the efficiency of innovative projects. Applying this approach would improve the efficiency of use of the technical-technological innovations of the industrial enterprises, having increased the profitability of intellectual activity.

  20. THE GENERAL METHODOLOGICAL PRINCIPLES OF COMBINED OPTIONAL ONLINE ENGLISH LANGUAGE TRAINING OF PRIMARY SCHOOL STUDENTS

    Directory of Open Access Journals (Sweden)

    E. I. Zadorozhnaya

    2016-01-01

    Full Text Available The aim of the publication is to demonstrate the implementation of general methodological principles of optional elementary school online foreign languages learning on an example of a virtual course for students of the second and third grades.Methods. The methods involve pedagogical modeling and projecting; the experience of foreign and Russian methodists, teachers and researchers is analysed, generalized and adjusted to the modern realias.Results and scientific novelty. On the basis of the requirements of the state educational standard and interest of pupils in computer games, the author’s technique of the combined facultative educational activities integrated to training in English at elementary school is developed. Online training in the form of games (additional to the major classroom activities gives a possibility of the choice of tasks interesting to children, studying the material at optimum comfortable and individual speed; it is possible to perform the tasks at home excluding the stressful situations that are specific to school examination, and allows pupils to master most effectively personal, metasubject and object competences. In general context of quality improvement of the general education, the modernization of educational process assumes not only justification of its new maintenance, but also restructuring of scientific and methodical support which has to meet essential needs of teachers and pupils, to facilitate access to necessary specific information. The lack of methodical base of creation of electronic distance resources for foreign-language education of younger school students has motivated the author to create own methodical concept of online training taking into account age of pupils. The complex of the general methodical principles is thoroughly considered; based on the general methodical principles, the proposed modular technique of the organization of an online class is created and implemented. Interactive blocks are

  1. Modeling technology innovation: how science, engineering, and industry methods can combine to generate beneficial socioeconomic impacts.

    Science.gov (United States)

    Stone, Vathsala I; Lane, Joseph P

    2012-05-16

    Government-sponsored science, technology, and innovation (STI) programs support the socioeconomic aspects of public policies, in addition to expanding the knowledge base. For example, beneficial healthcare services and devices are expected to result from investments in research and development (R&D) programs, which assume a causal link to commercial innovation. Such programs are increasingly held accountable for evidence of impact-that is, innovative goods and services resulting from R&D activity. However, the absence of comprehensive models and metrics skews evidence gathering toward bibliometrics about research outputs (published discoveries), with less focus on transfer metrics about development outputs (patented prototypes) and almost none on econometrics related to production outputs (commercial innovations). This disparity is particularly problematic for the expressed intent of such programs, as most measurable socioeconomic benefits result from the last category of outputs. This paper proposes a conceptual framework integrating all three knowledge-generating methods into a logic model, useful for planning, obtaining, and measuring the intended beneficial impacts through the implementation of knowledge in practice. Additionally, the integration of the Context-Input-Process-Product (CIPP) model of evaluation proactively builds relevance into STI policies and programs while sustaining rigor. The resulting logic model framework explicitly traces the progress of knowledge from inputs, following it through the three knowledge-generating processes and their respective knowledge outputs (discovery, invention, innovation), as it generates the intended socio-beneficial impacts. It is a hybrid model for generating technology-based innovations, where best practices in new product development merge with a widely accepted knowledge-translation approach. Given the emphasis on evidence-based practice in the medical and health fields and "bench to bedside" expectations for

  2. A hybrid MCDM framework combined with DEMATEL-based ANP to evaluate enterprise technological innovation capabilities assessment

    Directory of Open Access Journals (Sweden)

    Meng-Jong Kuan

    2014-08-01

    Full Text Available The efficient evaluation of technological innovation capabilities of enterprises is an important factor to enhance competitiveness. This paper aims to assess and to rank technological innovation evaluation criteria in order to provide a practical insight of systematic analysis by gathering the qualified experts’ opinions combined with three methods of multi-criteria decision making approach. A framework is proposed and uses a novel hybrid multiple criteria decision-making (MCDM model to address the dependence relationships of criteria with the aid of the Decision-Making Trial and Evaluation Laboratory (DEMATEL, analytical network process (ANP and VIKOR (VlseKriterijumska Optimizacija I Kompromisno Resenje. The study reports that the interaction between criteria is essential and influences technological innovation capabilities; furthermore, this ranking development of technological innovation capabilities assessment is also one of key management tools for managements of other related high- tech enterprises. Managers can then judge the need to improve and determine which criteria provide the most effective direction towards improvement.

  3. Canabalize and combine? Antecedents and outcomes of two key organizational innovation attitudes

    NARCIS (Netherlands)

    Harmanciogly, N.; Sääksjärvi, M.; Hultink, E.J.

    2009-01-01

    How can a firm ensure its survival and success in the pursuit of both radical and incremental new products? We propose that the answer to this question lies in the establishment of two important organizational innovation attitudes: firms’ willingness to cannibalize and product knowledge integration.

  4. Methodology for the assessment of innovative nuclear reactors and fuel cycles. Report of Phase 1B (first part) of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO)

    International Nuclear Information System (INIS)

    2004-12-01

    an innovative nuclear energy system (INS) to meet the overall target of sustainable energy supply. As well, the initial development of the INPRO method for the assessment of nuclear energy systems was carried out. The Basic Principles, User Requirements, and Criteria and the INPRO method of assessment, taken together, comprise the INPRO methodology. The INPRO methodology provides the possibility to take into account local, regional and global boundary conditions of IAEA Member States, including those of both developing and developed countries. Phase 1A was completed in June of 2003 with the publication of IAEA-TECDOC-1362, Guidance for the Evaluation of Innovative Nuclear Reactors and Fuel Cycles, which documented the results of the Phase 1A work. The next step of INPRO was immediately launched. In this step, referred to as Phase 1B (first part), INPRO arranged for some 14 case studies to be performed, by national teams or by individual experts from seven countries, to test and provide feedback on the applicability, consistency and completeness of the INPRO methodology. This report documents changes to the basic principles, user requirements, criteria and the method of assessment that resulted from the second step of INPRO (referred to as Phase 1B (first part)), which started in June 2003 and ended in December 2004. During this step, Member States and individual experts performed 14 case studies with the objective of testing and validating the INPRO methodology. Based on the feedback from these case studies and numerous consultancies mostly held at the IAEA, the INPRO methodology has been significantly updated and revised, as documented in this report. The ongoing and future activities of INPRO will lead to further modifications to the INPRO methodology, based on the feedback received from Member States in light of their experience in applying the methodology. Thus, additional reports will be issued, as appropriate, to update the INPRO methodology

  5. Analysis of Combined Data from Heterogeneous Study Designs: A Methodological Proposal from the Patient Navigation Research program

    Science.gov (United States)

    Roetzheim, Richard G.; Freund, Karen M.; Corle, Don K.; Murray, David M.; Snyder, Frederick R.; Kronman, Andrea C.; Jean-Pierre, Pascal; Raich, Peter C.; Holden, Alan E. C.; Darnell, Julie S.; Warren-Mears, Victoria; Patierno, Steven; Design, PNRP; Committee, Analysis

    2013-01-01

    Background The Patient Navigation Research Program (PNRP) is a cooperative effort of nine research projects, each employing its own unique study design. To evaluate projects such as PNRP, it is desirable to perform a pooled analysis to increase power relative to the individual projects. There is no agreed upon prospective methodology, however, for analyzing combined data arising from different study designs. Expert opinions were thus solicited from members of the PNRP Design and Analysis Committee Purpose To review possible methodologies for analyzing combined data arising from heterogeneous study designs. Methods The Design and Analysis Committee critically reviewed the pros and cons of five potential methods for analyzing combined PNRP project data. Conclusions were based on simple consensus. The five approaches reviewed included: 1) Analyzing and reporting each project separately, 2) Combining data from all projects and performing an individual-level analysis, 3) Pooling data from projects having similar study designs, 4) Analyzing pooled data using a prospective meta analytic technique, 5) Analyzing pooled data utilizing a novel simulated group randomized design. Results Methodologies varied in their ability to incorporate data from all PNRP projects, to appropriately account for differing study designs, and in their impact from differing project sample sizes. Limitations The conclusions reached were based on expert opinion and not derived from actual analyses performed. Conclusions The ability to analyze pooled data arising from differing study designs may provide pertinent information to inform programmatic, budgetary, and policy perspectives. Multi-site community-based research may not lend itself well to the more stringent explanatory and pragmatic standards of a randomized controlled trial design. Given our growing interest in community-based population research, the challenges inherent in the analysis of heterogeneous study design are likely to become

  6. The Combined Effect of Mere Exposure, Counterattitudinal Advocacy, and Art Criticism Methodology on Upper Elementary and Junior High Students' Affect Toward Art Works.

    Science.gov (United States)

    Hollingsworth, Patricia

    1983-01-01

    Results indicated that, for elementary students, art criticism was more effective than a combination of methodologies for developing positive affect toward art works. For junior high students, the combination methodology was more effective than art criticism, the exposure method, or the counterattitudinal advocacy method. (Author/SR)

  7. Innovation process

    DEFF Research Database (Denmark)

    Kolodovski, A.

    2006-01-01

    Purpose of this report: This report was prepared for RISO team involved in design of the innovation system Report provides innovation methodology to establish common understanding of the process concepts and related terminology The report does not includeRISO- or Denmark-specific cultural, econom...

  8. Environmental management of the OSBAT 24'' oil pipeline: methodological and conceptual innovations; Gestao ambiental do Oleoduto OSBAT 24{sup :} inovacoes metodologicas e conceituais

    Energy Technology Data Exchange (ETDEWEB)

    Garibaldi, Celia Maria; Serra, Ricardo Novaes; Martiniano, Flavio [LENC - Laboratorio de Engenharia e Consultoria Ltda., Cotia, SP (Brazil); Masumoto, Cinthia; Frazao, Luciana Rocha [PETROBRAS, Rio de Janeiro, RJ (Brazil)

    2008-07-01

    The objective of this article is to present considerations about the design, systematic and methodology used for conducting the environmental management of the work of maintenance of OSBAT 24'' Pipeline, what is located in the stretch between Sao Sebastiao City (center) and Camburi district, in Sao Paulo State. It presents a set of criteria, concepts, techniques, ideas and practices that stand out for its innovative character, and contribute effectively to the challenge of sustainable development, and new techniques of conciliation between environmental responsibility and investment in oil sector and gas. The general direction of the article is to reflect on the experience, seeking to broadcast both conceptual and methodological aspects responsible for the successes of OSBAT 24'' environmental management, and point out obstacles found in it's implementation. (author)

  9. An Innovative Methodology for Capturing Young Children's Curiosity, Imagination and Voices Using a Free App: Our Story

    Science.gov (United States)

    Canning, Natalie; Payler, Jane; Horsley, Karen; Gomez, Chris

    2017-01-01

    This study explores children's narratives of their curiosity and imagination through innovative use of an information technology app--Our Story. Novel use of the app allowed children to express and record their opinions they considered significant to them. The research captured children's approaches to everyday situations through their play.…

  10. Development of assessment methodology for locally wall-thinned pipe under combined loading

    International Nuclear Information System (INIS)

    Shim, Do Jun; Kim, Yun Jae; Kim, Young Jin; Park, Chi Yong

    2005-01-01

    Recently authors have proposed a new method to estimate failure strength of a pipe with local wall thinning subject to either internal pressure or global bending. The proposed method was based on the equivalent stress averaged over the minimum ligament in the locally wall thinned region, and the simple scheme to estimate the equivalent stress in the minimum ligament was proposed, based on the reference stress concept. This paper extends the new method to combined internal pressure and global bending. The proposed method is validated against FE results for various geometries of local wall thinning under combined loading. The effect of internal pressure is also investigated in the present study. Comparison of maximum moments, predicted according to the proposed method, with published full-scale pipe test data for locally wall-thinned pipes under combined internal pressure and global bending, shows good agreement

  11. Methodological Approach for the Sustainability Assessment of Development Cooperation Projects for Built Innovations Based on the SDGs and Life Cycle Thinking

    Directory of Open Access Journals (Sweden)

    Stephanie D. Maier

    2016-10-01

    Full Text Available This paper describes a methodological approach for a sustainability assessment of development cooperation projects. Between the scientific disciplines there is no agreement on the term of “sustainability”. Whereas the definition of sustainability within the context of development cooperation frequently highlights the long-term success of an intervention, the United Nations herald the inclusion of social, economic and environmental aspects. This paper proposes to bridge this gap by providing an analytical framework that uses nine impact category groups based on thematic priorities of sustainable development derived from the Sustainable Development Goals. Additionally, the long-term effectiveness of a project is taken into consideration. These impact category groups comprise the analytical framework, which is investigated by the Life Cycle Assessment and an indicator-based analysis. These data are obtained through empirical social research and the LCA inventory. The underlying concept is based on life cycle thinking. Taking up a multi-cycle model this study establishes two life cycles: first, the project management life cycle; and, second, the life cycle of a project’s innovation. The innovation’s life cycle is identified to have the greatest impact on the target region and the local people and is consequently of primary interest. This methodological approach enables an ex-post sustainability assessment of a built innovation of a development cooperation project and is tested on a case study on Improved Cooking Stoves in Bangladesh.

  12. Combining Statistical Methodologies in Water Quality Monitoring in a Hydrological Basin - Space and Time Approaches

    OpenAIRE

    Costa, Marco; A. Manuela Gonçalves

    2012-01-01

    In this work are discussed some statistical approaches that combine multivariate statistical techniques and time series analysis in order to describe and model spatial patterns and temporal evolution by observing hydrological series of water quality variables recorded in time and space. These approaches are illustrated with a data set collected in the River Ave hydrological basin located in the Northwest region of Portugal.

  13. Methodology for the combination of sub-daily Earth rotation from GPS and VLBI observations

    Science.gov (United States)

    Artz, T.; Bernhard, L.; Nothnagel, A.; Steigenberger, P.; Tesmer, S.

    2012-03-01

    A combination procedure of Earth orientation parameters from Global Positioning System (GPS) and Very Long Baseline Interferometry (VLBI) observations was developed on the basis of homogeneous normal equation systems. The emphasis and purpose of the combination was the determination of sub-daily polar motion (PM) and universal time (UT1) for a long time-span of 13 years. Time series with an hourly resolution and a model for tidal variations of PM and UT1-TAI (dUT1) were estimated. In both cases, 14-day nutation corrections were estimated simultaneously with the ERPs. Due to the combination procedure, it was warranted that the strengths of both techniques were preserved. At the same time, only a minimum of de-correlating or stabilizing constraints were necessary. Hereby, a PM time series was determined, whose precision is mainly dominated by GPS observations. However, this setup benefits from the fact that VLBI delivered nutation and dUT1 estimates at the same time. An even bigger enhancement can be seen for the dUT1 estimation, where the high-frequency variations are provided by GPS, while the long term trend is defined by VLBI. The estimated combined tidal PM and dUT1 model was predominantly determined from the GPS observations. Overall, the combined tidal model for the first time completely comprises the geometrical benefits of VLBI and GPS observations. In terms of root mean squared (RMS) differences, the tidal amplitudes agree with other empirical single-technique tidal models below 4 μ as in PM and 0.25 μ s in dUT1. The noise floor of the tidal ERP model was investigated in three ways resulting in about 1 μ as for diurnal PM and 0.07 μ s for diurnal dUT1 while the semi-diurnal components have a slightly better accuracy.

  14. Achieving Methodological Alignment When Combining QCA and Process tracing in Practice

    DEFF Research Database (Denmark)

    Beach, Derek

    2018-01-01

    resulting from two different understandings of causation underlying QCA and PT. The article first presents the research area used to explore the practical challenges of combining the two methods. I investigate the causes of congruence between what voters want and government positions in EU constitutional......This article explores the practical challenges one faces when combining Qualitative Comparative Analysis (QCA) and Process-tracing (PT) in a manner that is consistent with their underlying assumptions about the nature of causal relationships. While PT builds on a mechanism-based understanding...... of causation, QCA as a comparative method makes claims about counterfactual causal relationships. The consequence of this is that the analyst is forced to choose whether to be more in alignment with one or the other method. The article proceeds in four steps, exploring the challenges and opportunities...

  15. A discussion of recent methodologies for combining sensory and extrinsic product properties in consumer studies

    OpenAIRE

    Asioli, Daniele; Varela, Paula; Hersleth, Margrethe; Almli, Valerie Lengard; Olsen, Nina Veflen; Næs, Tormod

    2016-01-01

    - Understanding the interaction of sensory and extrinsic product attributes in consumer preferences has been identified as one of the key pillars for raising the likelihood of food products’ success in the market. Over the course of the last decade there has been increased attention on research emphasizing a combination of these food-choice driving parameters. This paper discusses progress made in the field focusing on three groups of methods: (i) conjoint hedonic methods (ii) “classic” he...

  16. Identification of vegetable oil botanical speciation in refined vegetable oil blends using an innovative combination of chromatographic and spectroscopic techniques.

    Science.gov (United States)

    Osorio, Maria Teresa; Haughey, Simon A; Elliott, Christopher T; Koidis, Anastasios

    2015-12-15

    European Regulation 1169/2011 requires producers of foods that contain refined vegetable oils to label the oil types. A novel rapid and staged methodology has been developed for the first time to identify common oil species in oil blends. The qualitative method consists of a combination of a Fourier Transform Infrared (FTIR) spectroscopy to profile the oils and fatty acid chromatographic analysis to confirm the composition of the oils when required. Calibration models and specific classification criteria were developed and all data were fused into a simple decision-making system. The single lab validation of the method demonstrated the very good performance (96% correct classification, 100% specificity, 4% false positive rate). Only a small fraction of the samples needed to be confirmed with the majority of oils identified rapidly using only the spectroscopic procedure. The results demonstrate the huge potential of the methodology for a wide range of oil authenticity work. Copyright © 2014 Elsevier Ltd. All rights reserved.

  17. Combining a weighted caseload study with an organisational analysis in courts: first experiences with a new methodological approach in Switzerland

    Directory of Open Access Journals (Sweden)

    Daniela Winkler

    2015-07-01

    Full Text Available Determining the weighted caseload, i.e. the average amount of work time used for processing cases of different case categories, using different methodological approaches of weighted caseload studies results in case weights that indicate the current performance of a court. However, as the weighted caseload is often used in allocating resources or cases, the results of a weighted caseload study may be contested with the argument it is not clear whether they are based on an average good performance or whether higher or lower values could be assumed if operational management were optimised or qualitative aspects taken into account. Suitable methods therefore usually include quality adjustments of the weighted caseload. Also, the values can be validated using benchmarking. In Switzerland there is a general lack of workload measurement in courts. Therefore, in an analysis of the courts and in the Cantonal Prosecutor’s Office of a Swiss canton another method of validating weighted caseload values has been applied: the combination of a weighted caseload study with an organisational analysis. This paper introduces the new methodological approach and outlines preliminary methodological findings.

  18. Guidance for the application of an assessment methodology for innovative nuclear energy systems. INPRO manual - Physical protection. Vol. 6 of the final report of phase 1 of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO)

    International Nuclear Information System (INIS)

    2008-11-01

    The International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) was initiated in the year 2000, based on a resolution of the IAEA General Conference (GC(44)/RES/21). The main objectives of INPRO are (1) to help to ensure that nuclear energy is available to contribute in fulfilling energy needs in the 21st century in a sustainable manner, (2) to bring together both technology holders and technology users to consider jointly the international and national actions required to achieve desired innovations in nuclear reactors and fuel cycles; and (3) to create a forum to involve all relevant stakeholders that will have an impact on, draw from, and complement the activities of existing institutions, as well as ongoing initiatives at the national and international level. This document follows the guidelines of the INPRO report M ethodology for the assessment of innovative nuclear reactors and fuel cycles, Report of Phase 1B (first part) of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) , IAEA-TECDOC-1434 (2004), together with its previous report G uidance for the evaluation for innovative nuclear reactors and fuel cycles, Report of Phase 1A of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO), IAEATECDOC-1362 (2003). This INPRO manual is comprised of an overview volume and eight additional volumes covering the areas of economics (Volume 2), infrastructure (Volume 3), waste management (Volume 4), proliferation resistance (Volume 5), physical protection (Volume 6), environment (Volume 7), safety of reactors (Volume 8), and safety of nuclear fuel cycle facilities (Volume 9). The INPRO Manual for the area of physical protection (Volume 6) provides guidance to the assessor of an INS (innovative nuclear energy system) under a physical protection regime in a country that is planning to install a nuclear power program (or maintaining or enlarging an existing one), and describes the application of the

  19. Lessons Learned from Nuclear Energy System Assessments (NESA) Using the INPRO Methodology. A Report of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO)

    International Nuclear Information System (INIS)

    2009-11-01

    The International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) was initiated in 2001 on the basis of a resolution of the IAEA General Conference in 2000 (GC(44)/RES/21). INPRO activities have since been continuously endorsed by resolutions of IAEA General Conferences and by the General Assembly of the United Nations. The objectives of INPRO are to: Help ensure that nuclear energy is available to contribute, in a sustainable manner, to meeting the energy needs of the 21st century; Bring together technology holders and users so that they can consider jointly the international and national actions required for achieving desired innovations in nuclear reactors and fuel cycles. INPRO is proceeding in steps. In its first step, referred to as Phase 1, 2001 to 2006, INPRO developed a set of basic principles, user requirements and criteria together with an assessment method, which taken together, comprise the INPRO methodology for the evaluation of innovative nuclear energy systems. To provide additional guidance in using the INPRO methodology an INPRO Manual was developed; it is comprised of an overview volume and eight additional volumes covering the areas of economics, infrastructure, waste management, proliferation resistance, physical protection, environment, safety of reactors, and safety of the nuclear fuel cycle facilities. Based on a decision of the 9 INPRO steering committee in July 2006, INPRO has entered into Phase 2. This phase has three main directions of activity: methodology improvement, infrastructure/institutional aspects and collaborative projects. As of March 2009, INPRO had 28 members: Argentina, Armenia, Belarus, Belgium, Brazil, Bulgaria, Canada, Chile, China, Czech Republic, France, Germany, India, Indonesia, Japan, Republic of Korea, Morocco, Netherlands, Pakistan, the Russian Federation, Slovakia, South Africa, Spain, Switzerland, Turkey, Ukraine, United States of America and the European Commission. This IAEA-TECDOC is part of

  20. A Combined Fuzzy-AHP and Fuzzy-GRA Methodology for Hydrogen Energy Storage Method Selection in Turkey

    Directory of Open Access Journals (Sweden)

    Aytac Yildiz

    2013-06-01

    Full Text Available In this paper, we aim to select the most appropriate Hydrogen Energy Storage (HES method for Turkey from among the alternatives of tank, metal hydride and chemical storage, which are determined based on expert opinions and literature review. Thus, we propose a Buckley extension based fuzzy Analytical Hierarchical Process (Fuzzy-AHP and linear normalization based fuzzy Grey Relational Analysis (Fuzzy-GRA combined Multi Criteria Decision Making (MCDM methodology. This combined approach can be applied to a complex decision process, which often makes sense with subjective data or vague information; and used to solve to solve HES selection problem with different defuzzification methods. The proposed approach is unique both in the HES literature and the MCDM literature.

  1. Innovative techniques for image-guided ablation of benign thyroid nodules: Combined ethanol and radiofrequency ablation

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hye Sun; Baek, Jung Hwan; Choi, Young Jun; Lee, Jeong Hyun [Dept. of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul (Korea, Republic of)

    2017-06-15

    In the treatment of benign thyroid nodules, ethanol ablation (EA), and radiofrequency ablation (RFA) have been suggested for cystic and solid thyroid nodules, respectively. Although combining these ablation techniques may be effective, no guidelines for or reviews of the combination have been published. Currently, there are three ways of combining EA and RFA: additional RFA is effective for treatment of incompletely resolved symptoms and solid residual portions of a thyroid nodule after EA. Additional EA can be performed for the residual unablated solid portion of a nodule after RFA if it is adjacent to critical structures (e.g., trachea, esophagus, and recurrent laryngeal nerve). In the concomitant procedure, ethanol is injected to control venous oozing after aspiration of cystic fluid prior to RFA of the remaining solid nodule.

  2. Combining rigour with relevance: a novel methodology for testing Chinese herbal medicine.

    Science.gov (United States)

    Flower, Andrew; Lewith, George; Little, Paul

    2011-03-24

    There is a need to develop an evidence base for Chinese herbal medicine (CHM) that is both rigorous and reflective of good practice. This paper proposes a novel methodology to test individualised herbal decoctions using a randomised, double blinded, placebo controlled clinical trial. A feasibility study was conducted to explore the role of CHM in the treatment of endometriosis. Herbal formulae were pre-cooked and dispensed as individual doses in sealed plastic sachets. This permitted the development and testing of a plausible placebo decoction. Participants were randomised at a distant pharmacy to receive either an individualised herbal prescription or a placebo. The trial met the predetermined criteria for good practice. Neither the participants nor the practitioner-researcher could reliably identify group allocation. Of the 28 women who completed the trial, in the placebo group (n=15) 3 women (20%) correctly guessed they were on placebo, 8 (53%) thought they were on herbs and 4 (27%) did not know which group they had been allocated to. In the active group (n=13) 2 (15%) though they were on placebo, 8 (62%) thought they were on herbs and 3 (23%) did not know. Randomisation, double blinding and allocation concealment were successful and the study model appeared to be feasible and effective. It is now possible to subject CHM to rigorous scientific scrutiny without compromising model validity. Improvement in the design of the placebo using food colourings and flavourings instead of dried food will help guarantee the therapeutic inertia of the placebo decoction. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  3. Methodological Approaches to Ensuring Innovative Development of Metallurgical Enterprises on the Basis of Principles of Economic Nationalism

    Directory of Open Access Journals (Sweden)

    Denysov Kostyantyn V.

    2017-01-01

    Full Text Available The economic, energy and environmental aspects of the activities of metallurgical enterprises are analyzed in the context of the need to ensure their sustainable development. The high energy intensity of the production process, the low efficiency and irrational structure of capital expenditures for environmental protection, the dominance of material costs in the final cost of finished products at the expense of labor and social contributions are indicated. There proved the low effectiveness of the previous measures of the industrial policy of the metallurgical industry innovative development that were not in compliance with the requirements of the WTO and led to taking compensatory measures against the Ukrainian steel on world markets. The potential of economic nationalism as a system for ensuring the innovative development of the metallurgical industry is considered. There determined the priorities of the industrial policy for the development of metallurgical enterprises based on the principles of economic nationalism and taking into account the global trends in the development of trade and economic relations and Ukraine’s commitments to the WTO.

  4. Combined evaluations of competency to stand trial and mental state at the time of the offense: An overlooked methodological consideration?

    Science.gov (United States)

    Kois, Lauren; Wellbeloved-Stone, James M; Chauhan, Preeti; Warren, Janet I

    2017-06-01

    Combined evaluations of competency to stand trial (CST; competency) and mental state at the time of the offense (MSO; sanity) frequently co-occur. However, most research examines the 2 as discrete constructs without considering 4 potential combined evaluation outcomes: competent-sane, incompetent-sane, competent-insane, and incompetent-insane. External validity can be improved if research more closely mirrored practice. It may be incorrect to assume incompetent defendants are similar across CST-only and combined evaluations, and insane defendants are similar across MSO-only and combined evaluations. Using a sample of 2,751 combined evaluations, we examined demographic, clinical, offense, evaluation, and psycholegal characteristics associated with evaluators' combined evaluation opinions. Multinomial regression analyses revealed older defendants were more likely to be opined incompetent-insane. Defendants with psychotic disorders were more often opined insane, regardless of competency status. Affective diagnoses predicted competent-insane opinions. Developmental disorders were closely related to incompetence, regardless of sanity status. Defendants with organic disorders tended to have global psycholegal impairment, in that they were more often opined incompetent-insane, incompetent-sane, or competent-insane, relative to competent-sane. Prior hospitalization predicted competent-insane relative to competent-sane opinions. Defendants not under the influence of a substance during the offense or with no prior convictions were more likely to be opined insane, regardless of competency status. We interpret these findings in light of psycholegal theory and provide recommendations for research and practice. Collectively, results suggest incorporation of combined evaluations into CST and MSO research is an important methodological consideration not to be overlooked. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  5. An innovative device for powders classification based on combined aerodynamic and electrostatic separation of particles

    Science.gov (United States)

    Piriou, Bruno; Mayer-Laigle, Claire; Maalel, Firas; Plissot, Jorys; Rouau, Xavier

    2017-06-01

    An innovative separator have been developed which aims at sorting out powders fractions according to aerodynamic and electrostatic properties of particles. The prototype is composed of a projection unit, a separation module and a classification/collection zone. The projection part is ensured by a pressurized gun. The separation module is conceived to disperse particles according to front and transverse directions. At the output of the gun, electrodes can be disposed to deviate the trajectory of charged particles. The classification part is made of a series of collecting bins. Starch, fine ash powders, and mixtures of these two materials were used to test the working of the separator. The efficiency of the separation was assessed by yields and particle sizes distribution of the collected fractions in the different bins. An aerodynamic classification was achieved along the main axis, with the finest particles crossing larger distances. With a blend of starch and ash, particles from both materials were unevenly distributed in the classifyier, opening the way to a possible separation based simply on aerodynamic properties. When an electric deviation was applied in addition to the projection of powders, the distribution of particles in the collecting part was modified.

  6. An innovative device for powders classification based on combined aerodynamic and electrostatic separation of particles

    Directory of Open Access Journals (Sweden)

    Piriou Bruno

    2017-01-01

    Full Text Available An innovative separator have been developed which aims at sorting out powders fractions according to aerodynamic and electrostatic properties of particles. The prototype is composed of a projection unit, a separation module and a classification/collection zone. The projection part is ensured by a pressurized gun. The separation module is conceived to disperse particles according to front and transverse directions. At the output of the gun, electrodes can be disposed to deviate the trajectory of charged particles. The classification part is made of a series of collecting bins. Starch, fine ash powders, and mixtures of these two materials were used to test the working of the separator. The efficiency of the separation was assessed by yields and particle sizes distribution of the collected fractions in the different bins. An aerodynamic classification was achieved along the main axis, with the finest particles crossing larger distances. With a blend of starch and ash, particles from both materials were unevenly distributed in the classifyier, opening the way to a possible separation based simply on aerodynamic properties. When an electric deviation was applied in addition to the projection of powders, the distribution of particles in the collecting part was modified.

  7. Using an innovative combination of quality-by-design and green analytical chemistry approaches for the development of a stability indicating UHPLC method in pharmaceutical products.

    Science.gov (United States)

    Boussès, Christine; Ferey, Ludivine; Vedrines, Elodie; Gaudin, Karen

    2015-11-10

    An innovative combination of green chemistry and quality by design (QbD) approach is presented through the development of an UHPLC method for the analysis of the main degradation products of dextromethorphan hydrobromide. QbD strategy was integrated to the field of green analytical chemistry to improve method understanding while assuring quality and minimizing environmental impacts, and analyst exposure. This analytical method was thoroughly evaluated by applying risk assessment and multivariate analysis tools. After a scouting phase aimed at selecting a suitable stationary phase and an organic solvent in accordance with green chemistry principles, quality risk assessment tools were applied to determine the critical process parameters (CPPs). The effects of the CPPs on critical quality attributes (CQAs), i.e., resolutions, efficiencies, and solvent consumption were further evaluated by means of a screening design. A response surface methodology was then carried out to model CQAs as function of the selected CPPs and the optimal separation conditions were determined through a desirability analysis. Resulting contour plots enabled to establish the design space (DS) (method operable design region) where all CQAs fulfilled the requirements. An experimental validation of the DS proved that quality within the DS was guaranteed; therefore no more robustness study was required before the validation. Finally, this UHPLC method was validated using the concept of total error and was used to analyze a pharmaceutical drug product. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. A Study on Establishing National Technology Strategy of Fusion Energy Development: Combining PEST-SWOT Methodologies

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Han Soo; Choi, Won Jae; Tho, Hyun Soo; Kang, Dong Yup; Kim, In Chung [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2012-05-15

    Nuclear fusion, the joining of light nuclei of hydrogen into heavier nuclei of helium, has potential environmental, safety and proliferation characteristics as an energy source. It can also, provide an adequate amount of fuel to power civilization for a long time compared to human history. It is, however, more challenging to convert to an energy source than nuclear fission. To overcome this, Korea enacted a law to promote the development of fusion as an energy source in 2007. In accordance with this law, the government will establish a promotion plan to develop fusion energy, including policy goals, a framework, strategies, infrastructure, funding, human resources, international cooperation and etc. This will be reviewed every five years. This paper is focused on the combining PEST (political, economic, social and technological) method with SWOT (strength, weakness, opportunity and threat) analysis, which is a prerequisite to form national fusion energy technology strategy

  9. A Study on Establishing National Technology Strategy of Fusion Energy Development: Combining PEST-SWOT Methodologies

    International Nuclear Information System (INIS)

    Chang, Han Soo; Choi, Won Jae; Tho, Hyun Soo; Kang, Dong Yup; Kim, In Chung

    2012-01-01

    Nuclear fusion, the joining of light nuclei of hydrogen into heavier nuclei of helium, has potential environmental, safety and proliferation characteristics as an energy source. It can also, provide an adequate amount of fuel to power civilization for a long time compared to human history. It is, however, more challenging to convert to an energy source than nuclear fission. To overcome this, Korea enacted a law to promote the development of fusion as an energy source in 2007. In accordance with this law, the government will establish a promotion plan to develop fusion energy, including policy goals, a framework, strategies, infrastructure, funding, human resources, international cooperation and etc. This will be reviewed every five years. This paper is focused on the combining PEST (political, economic, social and technological) method with SWOT (strength, weakness, opportunity and threat) analysis, which is a prerequisite to form national fusion energy technology strategy

  10. Online Innovation

    DEFF Research Database (Denmark)

    Vujovic, Sladjana; Ulhøi, John Parm

    2008-01-01

      Purpose - The aim of this paper is to investigate the role of online networking during the innovation process, including its role(s) in communication, cooperation and coordination. The paper neither implicitly assumes that online computer-based networking is a prerequisite for the innovation...... process nor denies the possibility that innovation can emerge and successfully survive without it. It merely presupposes that, in cases of innovation where information and communication technologies play a substantial role, non-proprietarity may offer an interesting alternative to innovations based...... on proprietary knowledge. Design/methodology/approach - The paper borrows from the theory of communities-of-practice, which takes into account social relations, contacts, and the transfer and incorporation of knowledge. Open source innovation is not the exclusive preserve of computer nerds, but also has...

  11. Geostatistical radar-raingauge combination with nonparametric correlograms: methodological considerations and application in Switzerland

    Science.gov (United States)

    Schiemann, R.; Erdin, R.; Willi, M.; Frei, C.; Berenguer, M.; Sempere-Torres, D.

    2011-05-01

    Modelling spatial covariance is an essential part of all geostatistical methods. Traditionally, parametric semivariogram models are fit from available data. More recently, it has been suggested to use nonparametric correlograms obtained from spatially complete data fields. Here, both estimation techniques are compared. Nonparametric correlograms are shown to have a substantial negative bias. Nonetheless, when combined with the sample variance of the spatial field under consideration, they yield an estimate of the semivariogram that is unbiased for small lag distances. This justifies the use of this estimation technique in geostatistical applications. Various formulations of geostatistical combination (Kriging) methods are used here for the construction of hourly precipitation grids for Switzerland based on data from a sparse realtime network of raingauges and from a spatially complete radar composite. Two variants of Ordinary Kriging (OK) are used to interpolate the sparse gauge observations. In both OK variants, the radar data are only used to determine the semivariogram model. One variant relies on a traditional parametric semivariogram estimate, whereas the other variant uses the nonparametric correlogram. The variants are tested for three cases and the impact of the semivariogram model on the Kriging prediction is illustrated. For the three test cases, the method using nonparametric correlograms performs equally well or better than the traditional method, and at the same time offers great practical advantages. Furthermore, two variants of Kriging with external drift (KED) are tested, both of which use the radar data to estimate nonparametric correlograms, and as the external drift variable. The first KED variant has been used previously for geostatistical radar-raingauge merging in Catalonia (Spain). The second variant is newly proposed here and is an extension of the first. Both variants are evaluated for the three test cases as well as an extended evaluation

  12. General calibration methodology for a combined Horton-SCS infiltration scheme in flash flood modeling

    Science.gov (United States)

    Gabellani, S.; Silvestro, F.; Rudari, R.; Boni, G.

    2008-12-01

    Flood forecasting undergoes a constant evolution, becoming more and more demanding about the models used for hydrologic simulations. The advantages of developing distributed or semi-distributed models have currently been made clear. Now the importance of using continuous distributed modeling emerges. A proper schematization of the infiltration process is vital to these types of models. Many popular infiltration schemes, reliable and easy to implement, are too simplistic for the development of continuous hydrologic models. On the other hand, the unavailability of detailed and descriptive information on soil properties often limits the implementation of complete infiltration schemes. In this work, a combination between the Soil Conservation Service Curve Number method (SCS-CN) and a method derived from Horton equation is proposed in order to overcome the inherent limits of the two schemes. The SCS-CN method is easily applicable on large areas, but has structural limitations. The Horton-like methods present parameters that, though measurable to a point, are difficult to achieve a reliable estimate at catchment scale. The objective of this work is to overcome these limits by proposing a calibration procedure which maintains the large applicability of the SCS-CN method as well as the continuous description of the infiltration process given by the Horton's equation suitably modified. The estimation of the parameters of the modified Horton method is carried out using a formal analogy with the SCS-CN method under specific conditions. Some applications, at catchment scale within a distributed model, are presented.

  13. A combination of streamtube and geostatical simulation methodologies for the study of large oil reservoirs

    Energy Technology Data Exchange (ETDEWEB)

    Chakravarty, A.; Emanuel, A.S.; Bernath, J.A. [Chevron Petroleum Technology Company, LaHabra, CA (United States)

    1997-08-01

    The application of streamtube models for reservoir simulation has an extensive history in the oil industry. Although these models are strictly applicable only to fields under voidage balance, they have proved to be useful in a large number of fields provided that there is no solution gas evolution and production. These models combine the benefit of very fast computational time with the practical ability to model a large reservoir over the course of its history. These models do not, however, directly incorporate the detailed geological information that recent experience has taught is important. This paper presents a technique for mapping the saturation information contained in a history matched streamtube model onto a detailed geostatistically derived finite difference grid. With this technique, the saturation information in a streamtube model, data that is actually statistical in nature, can be identified with actual physical locations in a field and a picture of the remaining oil saturation can be determined. Alternatively, the streamtube model can be used to simulate the early development history of a field and the saturation data then used to initialize detailed late time finite difference models. The proposed method is presented through an example application to the Ninian reservoir. This reservoir, located in the North Sea (UK), is a heterogeneous sandstone characterized by a line drive waterflood, with about 160 wells, and a 16 year history. The reservoir was satisfactorily history matched and mapped for remaining oil saturation. A comparison to 3-D seismic survey and recently drilled wells have provided preliminary verification.

  14. Competitive Advantage through Innovation

    DEFF Research Database (Denmark)

    Brem, Alexander; Maier, Maximilian; Wimschneider, Christine

    2016-01-01

    Purpose The purpose of this paper is to describe how Nespresso achieved competitive advantage through innovation by changing the rules of the game in its industry. Design/methodology/approach Nespresso was analyzed based on public available secondary data, in combination with related academic...... concepts on innovation and competitive advantage. Findings The company succeeded by the thorough application of a strategy that, through perfect alignment, allowed the company to reach a unique market position. However, as described in the case, it took a relatively long time and the company came close...... as a source for competitive advantage. Research limitations/implications Especially given the current market situation, the case offers different starting points for discussion about innovation and long-term company success. Practical implications Especially before the current market situation, the case...

  15. Learning as Issue Framing in Agricultural Innovation Networks

    Science.gov (United States)

    Tisenkopfs, Talis; Kunda, Ilona; Šumane, Sandra

    2014-01-01

    Purpose: Networks are increasingly viewed as entities of learning and innovation in agriculture. In this article we explore learning as issue framing in two agricultural innovation networks. Design/methodology/approach: We combine frame analysis and social learning theories to analyse the processes and factors contributing to frame convergence and…

  16. General calibration methodology for a combined Horton-SCS infiltration scheme in flash flood modeling

    Directory of Open Access Journals (Sweden)

    S. Gabellani

    2008-12-01

    Full Text Available Flood forecasting undergoes a constant evolution, becoming more and more demanding about the models used for hydrologic simulations. The advantages of developing distributed or semi-distributed models have currently been made clear. Now the importance of using continuous distributed modeling emerges. A proper schematization of the infiltration process is vital to these types of models. Many popular infiltration schemes, reliable and easy to implement, are too simplistic for the development of continuous hydrologic models. On the other hand, the unavailability of detailed and descriptive information on soil properties often limits the implementation of complete infiltration schemes. In this work, a combination between the Soil Conservation Service Curve Number method (SCS-CN and a method derived from Horton equation is proposed in order to overcome the inherent limits of the two schemes. The SCS-CN method is easily applicable on large areas, but has structural limitations. The Horton-like methods present parameters that, though measurable to a point, are difficult to achieve a reliable estimate at catchment scale. The objective of this work is to overcome these limits by proposing a calibration procedure which maintains the large applicability of the SCS-CN method as well as the continuous description of the infiltration process given by the Horton's equation suitably modified. The estimation of the parameters of the modified Horton method is carried out using a formal analogy with the SCS-CN method under specific conditions. Some applications, at catchment scale within a distributed model, are presented.

  17. Diffusion of innovative agricultural production systems for sustainable development of small islands: A methodological approach based on the science of complexity

    Science.gov (United States)

    Barbera, Guiseppe; Butera, Federico M.

    1992-09-01

    In order to develop small islands, not only must a vital agricultural system be maintained, but the range of opportunities for tourism must be increased with respect to both the seaside and the environmental features of the rural landscape. As an alternative to the traditional and economically declining ones, many innovative production processes can be identified, but their success depends on their interaction with the physical, biological, economic and social environment. In order to identify the main nodes and the most critical interactions, so as to increase the probability of success of a new productive process, a methodological approach based on the science of complexity is proposed for the cultivation of capers ( Capparis spinosa L.) on the island of Pantelleria. The methodology encompasses the identification of actors and factors involved. the quantitative evaluation of their interactions with the different stages of the productive process, and a quasiquantitative evaluation of the probability that the particular action will be performed successfully. The study of “traditional,” “modernized,” and “modernized-sustainable” processes, shows that the modernized-sustainable process offers mutually reinforcing opportunities in terms of an integrated development of high-quality agricultural products and the enhancement of environmental features, in conjunction with high-efficiency production techniques, in conjunction with high-efficiency production techniques, in a way that suits the development of Pantelleria. There is a high probability of failure, however, as a result of the large number of critical factors. Nevertheless, the present study indicates which activities will enhance the probability of successful innovation in the production process.

  18. Methodology for determining the effectiveness of implementing innovations and proposals for improving production in oil industry branches

    Energy Technology Data Exchange (ETDEWEB)

    Luzin, V I; Logachev, V M

    1980-01-01

    An appropriate technology is applied with a specialized method for determining the economic effectiveness of new technological inventions and efficiency in the national economy from 1977 until the present. An analogous project has also been developed in order to consider and examine specific elements of the oil industry. This project incorporates a specialized methodology to examine the principle factors behind oil production-extraction and associated with scientific-technical progress. This approach applies technical and efficiency proposals and considered new inventions during the planning stages in order to calculate the economic effectiveness of these new inputs. The principle methodological premise for the calculation of annual economic effectiveness during the planning stages is based upon economic stimulation inspired by new inventions and efficiency experts. A formula is provided for conducting such calculations. Examples are provided to illustrate how the annual economic effectiveness of a depulsator (a device used to improve the quality of separation for oil-gas mixtures while at the same time reducing oil loss) is calculated. The authors offer a detailed examination of methods used to accurately reflect the economic effectiveness of new technologies within the spheres of planning and calculating indicators for enterprises and production organization in the oil industry, both by individual branch, and for the entire industry.

  19. A Case Study of a "Collaborative Organizational Innovation" Intervention, Combining Action Research and Design-Thinking Methodologies

    Science.gov (United States)

    Wetzler, Jeffrey Richard

    2013-01-01

    For decades, debates have raged about performance management in education. While it is essential to understand the degree of student learning and the nature of teacher impact in education systems, when attempts at managing outcomes go wrong, the consequences can be problematic. National Education Organization (a pseudonym for the organization…

  20. Optimization of formulation of soy-cakes baked in infrared-microwave combination oven by response surface methodology.

    Science.gov (United States)

    Şakıyan, Özge

    2015-05-01

    The aim of present work is to optimize the formulation of a functional cake (soy-cake) to be baked in infrared-microwave combination oven. For this optimization process response surface methodology was utilized. It was also aimed to optimize the processing conditions of the combination baking. The independent variables were the baking time (8, 9, 10 min), the soy flour concentration (30, 40, 50 %) and the DATEM (diacetyltartaric acid esters of monoglycerides) concentration (0.4, 0.6 and 0.8 %). The quality parameters that were examined in the study were specific volume, weight loss, total color change and firmness of the cake samples. The results were analyzed by multiple regression; and the significant linear, quadratic, and interaction terms were used in the second order mathematical model. The optimum baking time, soy-flour concentration and DATEM concentration were found as 9.5 min, 30 and 0.72 %, respectively. The corresponding responses of the optimum points were almost comparable with those of conventionally baked soy-cakes. So it may be declared that it is possible to produce high quality soy cakes in a very short time by using infrared-microwave combination oven.

  1. Sources of innovation, their combinations and strengths – benefits at the NPD project level

    DEFF Research Database (Denmark)

    Tranekjer, Tina Lundø; Søndergaard, Helle Alsted

    2013-01-01

    External sourcing is increasingly seen as important for obtaining new and valuable knowledge and resources for new product development. However, when it comes to the specifics of choosing between sources and types of relationships, little is known on the NPD project level. This paper strengthens...... not only consider the potential benefits of collaboration with external sources but also the downsides, including higher cost and lengthier projects. Firms should look for opportunities in the combination of sources if they are to gain advantages of collaboration, as our analyses show that a mix of market...... and science sources is related to decreased costs. Additionally, if firms are looking for increased market performance, they should aim at collaborating with suppliers that have a similar knowledge base, whereas if the aim is lower project costs, collaboration with a customer with a similar knowledge base...

  2. Conducting evaluation research with children exposed to violence: How technological innovations in methodologies and data collection may enhance the process.

    Science.gov (United States)

    Wall, Michael A; Jenney, Angelique; Walsh, Margaret

    2018-01-20

    Research and program evaluation processes that engage children and youth are becoming much more common due to influences from children's rights and the acknowledgement that children have the capacity to contribute to research, both as participants and co-researchers (Roberts, 2017). Recent technological advances in the form of tablet and internet-based applications have provided researchers with additional methodological tools to better capture the voices and experiences of children and their caregivers (Livingstone & Blum-Ross, 2017). However, little has been written on the ways in which these new technological advances can improve research experiences for children who have been exposed to intimate partner and family violence, as well as other forms of traumatic experiences. This paper provides a review of current literature and a case study example of how one children's mental health agency has implemented tablet-based data collection procedures. Copyright © 2018. Published by Elsevier Ltd.

  3. Construction scheduled delay risk assessment by using combined AHP-RII methodology for an international NPP project

    International Nuclear Information System (INIS)

    Hossen, Mufazal Muhammed; Kang, Sun Koo; Kim, Jong Hyun

    2015-01-01

    In this study, Nuclear Power Plant (NPP) construction schedule delay risk assessment methodology is developed and the construction delay risk is assessed for turnkey international NPP projects. Three levels of delay factors were selected through literature review and discussions with nuclear industry experts. A questionnaire survey was conducted on the basis of an analytic hierarchy process (AHP) and Relative Importance Index (RII) methods and the schedule delay risk is assessed qualitatively and quantitatively by severity and frequency of occurrence of delay factors. This study assigns four main delay factors to the first level: main contractor, utility, regulatory authority, and financial and country factor. The second and the third levels are designed with 12 sub-factors and 32 sub-sub-factors, respectively. This study finds the top five most important sub-sub-factors, which are as follows: policy changes, political instability and public intervention; uncompromising regulatory criteria and licensing documents conflicting with existing regulations; robust design document review procedures; redesign due to errors in design and design changes; and worldwide shortage of qualified and experienced nuclear specific equipment manufacturers. The proposed combined AHP-RII methodology is capable of assessing delay risk effectively and efficiently. Decision makers can apply risk informed decision making to avoid unexpected construction delays of NPPs

  4. Construction scheduled delay risk assessment by using combined AHP-RII methodology for an international NPP project

    Energy Technology Data Exchange (ETDEWEB)

    Hossen, Mufazal Muhammed; Kang, Sun Koo; Kim, Jong Hyun [KEPCO International Nuclear Graduate School (KINGS), Ulsan (Korea, Republic of)

    2015-04-15

    In this study, Nuclear Power Plant (NPP) construction schedule delay risk assessment methodology is developed and the construction delay risk is assessed for turnkey international NPP projects. Three levels of delay factors were selected through literature review and discussions with nuclear industry experts. A questionnaire survey was conducted on the basis of an analytic hierarchy process (AHP) and Relative Importance Index (RII) methods and the schedule delay risk is assessed qualitatively and quantitatively by severity and frequency of occurrence of delay factors. This study assigns four main delay factors to the first level: main contractor, utility, regulatory authority, and financial and country factor. The second and the third levels are designed with 12 sub-factors and 32 sub-sub-factors, respectively. This study finds the top five most important sub-sub-factors, which are as follows: policy changes, political instability and public intervention; uncompromising regulatory criteria and licensing documents conflicting with existing regulations; robust design document review procedures; redesign due to errors in design and design changes; and worldwide shortage of qualified and experienced nuclear specific equipment manufacturers. The proposed combined AHP-RII methodology is capable of assessing delay risk effectively and efficiently. Decision makers can apply risk informed decision making to avoid unexpected construction delays of NPPs.

  5. Innovative methodology for intercomparison of radionuclide calibrators using short half-life in situ prepared radioactive sources

    International Nuclear Information System (INIS)

    Oliveira, P. A.; Santos, J. A. M.

    2014-01-01

    Purpose: An original radionuclide calibrator method for activity determination is presented. The method could be used for intercomparison surveys for short half-life radioactive sources used in Nuclear Medicine, such as 99m Tc or most positron emission tomography radiopharmaceuticals. Methods: By evaluation of the resulting net optical density (netOD) using a standardized scanning method of irradiated Gafchromic XRQA2 film, a comparison of the netOD measurement with a previously determined calibration curve can be made and the difference between the tested radionuclide calibrator and a radionuclide calibrator used as reference device can be calculated. To estimate the total expected measurement uncertainties, a careful analysis of the methodology, for the case of 99m Tc, was performed: reproducibility determination, scanning conditions, and possible fadeout effects. Since every factor of the activity measurement procedure can influence the final result, the method also evaluates correct syringe positioning inside the radionuclide calibrator. Results: As an alternative to using a calibrated source sent to the surveyed site, which requires a relatively long half-life of the nuclide, or sending a portable calibrated radionuclide calibrator, the proposed method uses a source preparedin situ. An indirect activity determination is achieved by the irradiation of a radiochromic film using 99m Tc under strictly controlled conditions, and cumulated activity calculation from the initial activity and total irradiation time. The irradiated Gafchromic film and the irradiator, without the source, can then be sent to a National Metrology Institute for evaluation of the results. Conclusions: The methodology described in this paper showed to have a good potential for accurate (3%) radionuclide calibrators intercomparison studies for 99m Tc between Nuclear Medicine centers without source transfer and can easily be adapted to other short half-life radionuclides

  6. Detecting Social Innovation agency

    DEFF Research Database (Denmark)

    Pel, Bonno; Dorland, Jens; Wittmayer, Julia

    2017-01-01

    Considering that it is important for the social innovation research field to confront its methodological challenges, this contribution addresses the challenge of choosing appropriate units of analysis. In processes of transformative social innovation, the agency is distributed and therefore...

  7. Innovative Strategies to Develop Chemical Categories Using a Combination of Structural and Toxicological Properties

    Directory of Open Access Journals (Sweden)

    Monika Batke

    2016-09-01

    Full Text Available 1.AbstractInterest is increasing in the development of non-animal methods for toxicological evaluations. These methods are however, particularly challenging for complex toxicological endpoints such as repeated dose toxicity. European Legislation, e.g. the European Union´s Cosmetic Directive and REACH, demands the use of alternative methods. Frameworks, such as the Read-across Assessment Framework or the Adverse Outcome Pathway Knowledge Base, support the development of these methods. The aim of the project presented in this publication was to develop substance categories for a read-across with complex endpoints of toxicity based on existing databases. The basic conceptual approach was to combine structural similarity with shared mechanisms of action. Substances with similar chemical structure and toxicological profile form candidate categories suitable for read-across. We combined two databases on repeated dose toxicity, RepDose database and ELINCS database to form a common database for the identification of categories. The resulting database contained physicochemical, structural and toxicological data, which were refined and curated for cluster analyses. We applied the Predictive Clustering Tree (PCT approach for clustering chemicals based on structural and on toxicological information to detect groups of chemicals with similar toxic profiles and pathways/mechanisms of toxicity. As many of the experimental toxicity values were not available, this data was imputed by predicting them with a multi-label classification method, prior to clustering. The clustering results were evaluated by assessing chemical and toxicological similarities with the aim of identifying clusters with a concordance between structural information and toxicity profiles/mechanisms. From these chosen clusters, seven were selected for a quantitative read-across, based on a small ratio of NOAEL of the members with the highest and the lowest NOAEL in the cluster (<5. We discuss

  8. Development of an innovative two-stage process, a combination of acidogenic hydrogenesis and methanogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Han, S.K.; Shin, H.S. [Korea Advanced Inst. of Science and Technology, Daejeon (Korea, Republic of). Dept. of Civil and Enviromental Engineering

    2004-07-01

    Hydrogen produced from waste by means of fermentative bacteria is an attractive way to produce this fuel as an alternative to fossil fuels. It also helps treat the associated waste. The authors have undertaken to optimize acidogenic hydrogenesis and methanogenesis. Building on this, they then developed a two-stage process that produces both hydrogen and methane. Acidogenic hydrogenesis of food waste was investigated using a leaching bed reactor. The dilution rate was varied in order to maximize efficiency which was as high as 70.8 per cent. Further to this, an upflow anaerobic sludge blanket reactor converted the wastewater from acidogenic hydrogenesis into methane. Chemical oxygen demand (COD) removal rates exceeded 96 per cent up to a COD loading of 12.9 COD/l/d. After this, the authors devised a new two-stage process based on a combination of acidogenic hydrogenesis and methanogenesis. The authors report on results for this process using food waste as feedstock. 5 refs., 5 figs.

  9. City/industry/utility partnership leads to innovative combined heat and power project

    Energy Technology Data Exchange (ETDEWEB)

    Savage, J. [Savage and Associates, Quesnel, BC (Canada)

    2010-07-01

    This presentation discussed a combined heat and power (CHP) project that was launched in Quesnel, British Columbia. The CHP is being developed in phases in which new components will enter the system, providing added benefits. Hot oil from a sawmill bioenergy system will be used to heat lumber kilns, generate electricity at an Organic Rankine Cycle co-generation plant, and heat water for a District Energy Loop (DEL) to heat up to 22 existing buildings in the city as well as sawmill and planer buildings. The DEL piping would comprise a 5 kilometre loop. The energy would come from recovered sawmill space heating, recovered stack energy, and additional biomass energy. All of the district heating and 41 per cent of the power would be from heat recovered from the existing industrial operation. This bio-economy vision ultimately involves incorporating a biogas digester into the system to process food, regional organic waste, and pulp mill residuals, relying on bio-solids and heat from the mill. The fertilizer from the digester would then be used in a biomass plantation, which would provide materials to industry for many products, including bio-refining. This project evolved in response to concerns about the ecological effects and long-term economics of aggressive utilization of forest biomass. 15 figs.

  10. A combined linear optimisation methodology for water resources allocation in Alfeios River Basin (Greece) under uncertain and vague system conditions

    Science.gov (United States)

    Bekri, Eleni; Yannopoulos, Panayotis; Disse, Markus

    2013-04-01

    In the present study, a combined linear programming methodology, based on Li et al. (2010) and Bekri et al. (2012), is employed for optimizing water allocation under uncertain system conditions in the Alfeios River Basin, in Greece. The Alfeios River is a water resources system of great natural, ecological, social and economic importance for Western Greece, since it has the longest and highest flow rate watercourse in the Peloponnisos region. Moreover, the river basin was exposed in the last decades to a plethora of environmental stresses (e.g. hydrogeological alterations, intensively irrigated agriculture, surface and groundwater overexploitation and infrastructure developments), resulting in the degradation of its quantitative and qualitative characteristics. As in most Mediterranean countries, water resource management in Alfeios River Basin has been focused up to now on an essentially supply-driven approach. It is still characterized by a lack of effective operational strategies. Authority responsibility relationships are fragmented, and law enforcement and policy implementation are weak. The present regulated water allocation puzzle entails a mixture of hydropower generation, irrigation, drinking water supply and recreational activities. Under these conditions its water resources management is characterised by high uncertainty and by vague and imprecise data. The considered methodology has been developed in order to deal with uncertainties expressed as either probability distributions, or/and fuzzy boundary intervals, derived by associated α-cut levels. In this framework a set of deterministic submodels is studied through linear programming. The ad hoc water resources management and alternative management patterns in an Alfeios subbasin are analyzed and evaluated under various scenarios, using the above mentioned methodology, aiming to promote a sustainable and equitable water management. Li, Y.P., Huang, G.H. and S.L., Nie, (2010), Planning water resources

  11. Combining snow depth and innovative skier flow measurements in order to improve snow grooming techniques

    Science.gov (United States)

    Carmagnola, Carlo Maria; Albrecht, Stéphane; Hargoaa, Olivier

    2017-04-01

    In the last decades, ski resort managers have massively improved their snow management practices, in order to adapt their strategies to the inter-annual variability in snow conditions and to the effects of climate change. New real-time informations, such as snow depth measurements carried out on the ski slopes by grooming machines during their daily operations, have become available, allowing high saving, efficiency and optimization gains (reducing for instance the groomer fuel consumption and operation time and the need for machine-made snow production). In order to take a step forward in improving the grooming techniques, it would be necessary to keep into account also the snow erosion by skiers, which depends mostly on the snow surface properties and on the skier attendance. Today, however, most ski resort managers have only a vague idea of the evolution of the skier flows on each slope during the winter season. In this context, we have developed a new sensor (named Skiflux) able to measure the skier attendance using an infrared beam crossing the slopes. Ten Skiflux sensors have been deployed during the 2016/17 winter season at Val Thorens ski area (French Alps), covering a whole sector of the resort. A dedicated software showing the number of skier passages in real time as been developed as well. Combining this new Skiflux dataset with the snow depth measurements from grooming machines (Snowsat System) and the snow and meteorological conditions measured in-situ (Liberty System from Technoalpin), we were able to create a "real-time skiability index" accounting for the quality of the surface snow and its evolution during the day. Moreover, this new framework allowed us to improve the preparation of ski slopes, suggesting new strategies for adapting the grooming working schedule to the snow quality and the skier attendance. In the near future, this work will benefit from the advances made within the H2020 PROSNOW project ("Provision of a prediction system allowing

  12. Guidance for the application of an assessment methodology for Innovative Nuclear Energy Systems. INPRO manual - Economics. Vol. 2 of the final report of phase 1 of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO)

    International Nuclear Information System (INIS)

    2008-11-01

    The International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) was initiated in the year 2000, based on a resolution of the IAEA General Conference (GC(44)/RES/21). The main objectives of INPRO are (1) to help to ensure that nuclear energy is available to contribute in fulfilling energy needs in the 21st century in a sustainable manner, (2) to bring together both technology holders and technology users to consider jointly the international and national actions required to achieve desired innovations in nuclear reactors and fuel cycles; and (3) to create a forum to involve all relevant stakeholders that will have an impact on, draw from, and complement the activities of existing institutions, as well as ongoing initiatives at the national and international level. This publication elaborates on the guidance given in the INPRO report 'Methodology for the assessment of innovative nuclear reactors and fuel cycles', IAEA-TECDOC-1434 (2004), and the previous INPRO report 'Guidance for the evaluation for innovative nuclear reactors and fuel cycles', IAEA-TECDOC-1362 (2003) in the area of economics. The information presented in Volume 1 of the INPRO manual should be considered to be an integral part of this volume and the user should be familiar with that information. The goal of the INPRO Manual for the area of economics (Volume 2) is to provide guidance for performing an INPRO assessment, as described in Volume 1 of the INPRO manual, in the area of economics. The manual is not intended to provide guidance on how to design an INS to meet the INPRO requirements in the area of economics: rather, the focus is on the assessment method and the evaluation of the INPRO criteria in the area of economics. The INPRO assessor, i.e. the individual or group of individuals carrying out the assessment, is assumed to be knowledgeable in the area of economics and financial analysis. The INPRO assessment will either confirm that the INPRO economic criteria are fulfilled

  13. Guidance for the application of an assessment methodology for innovative nuclear energy systems. INPRO manual - Environment. Vol. 7 of the final report of phase 1 of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO)

    International Nuclear Information System (INIS)

    2008-11-01

    The International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) was initiated in the year 2000, based on a resolution of the IAEA General Conference (GC(44)/RES/21). The main objectives of INPRO are (1) to help to ensure that nuclear energy is available to contribute in fulfilling energy needs in the 21st century in a sustainable manner, (2) to bring together both technology holders and technology users to consider jointly the international and national actions required to achieve desired innovations in nuclear reactors and fuel cycles; and (3) to create a forum to involve all relevant stakeholders that will have an impact on, draw from, and complement the activities of existing institutions, as well as ongoing initiatives at the national and international level. The INPRO manual is comprised of an overview volume (No. 1), and eight additional volumes covering the areas of economics (Volume 2), infrastructure (Volume 3), waste management (Volume 4), proliferation resistance (Volume 5), physical protection (Volume 6), environment (laid out in this volume) (Volume 7), safety of nuclear reactors (Volume 8), and safety of nuclear fuel cycle facilities (Volume 9). This volume should provide guidance to the assessor of an INS that is planned (or maintained or enlarged), describing how to apply the INPRO methodology in the area of environment. It follows the guidelines of the INPRO report 'Methodology for the assessment of innovative nuclear reactors and fuel cycles', together with its previous report 'Guidance for the evaluation for innovative nuclear reactors and fuel cycles'. The INPRO Manual starts with an introduction in Chapter 1. In Chapter 2 an overview is presented what kind of information must be available to an INPRO assessor to perform his environmental assessment. In Chapter 3 the background of the INPRO environmental basic principle BP1, the corresponding user requirements (UR) and criteria (CR) consisting of indicators (IN) and acceptance

  14. Combining a 2-D multiphase CFD model with a Response Surface Methodology to optimize the gasification of Portuguese biomasses

    International Nuclear Information System (INIS)

    Silva, Valter; Rouboa, Abel

    2015-01-01

    Highlights: • A multiphase CFD model was combined with RSM. • Gasification optimal operating conditions were found in a pilot scale reactor. • Syngas quality indices were optimized in a biomass gasification process. • Propagation of error methodology was combined with a CFD model and RSM. - Abstract: This paper presents a study to evaluate the potential of Portuguese biomasses (coffee husks, forest residues and vine pruning residues) to produce syngas for different applications. By using a 2-D Eulerian–Eulerian approach within the CFD framework, a design of several computer experiments was developed and were used as analysis tools the response surface method (RSM) and the propagation of error (POE) approach. The CFD model was validated under experimental results collected at a semi-industrial reactor. For design purposes, temperature, steam to biomass ratio (SBR) and the type of biomass were selected as input factors. The responses were the H 2 generation, the H 2 /CO ratio, the CH 4 /H 2 ratio, the carbon conversion and the cold gas efficiency. It was concluded that after an optimization procedure to determine the operating conditions, vine pruning residues could show very promising results considering some of the typical syngas indice standards for commercial purposes. From the optimization procedure, it was also concluded that forest residues are preferable for domestic natural gas applications and vine pruning residues for fuel cells and integrated gasification systems application. By using the RSM combined with POE, it was verified that the operating conditions to get higher performances do not always coincide with those necessary to obtain a stable syngas composition

  15. Combined U-Pb and Lu-Hf isotope analyses by laser ablation MC-ICP-MS: methodology and applications

    Energy Technology Data Exchange (ETDEWEB)

    Matteini, Massimo; Dantas, Elton L.; Pimentel, Marcio M.; Bühn, Bernhard, E-mail: massimo@unb.br [Universidade de Brasilia (UnB), DF (Brazil). Instituto de Geociencias

    2010-06-15

    The Lutetium-Hafnium isotopic system represents one of the most innovative and powerful tools for geochronology and isotopic studies. Combined U-Pb and Lu-Hf in situ analyses on zircon by LA-MC-ICP-MS permit to characterize isotopically the host magma from which it crystallized furnishing significant information for sediment provenance and crustal evolution studies. In this paper e describe the Lu-Hf systematic by LA-MC-ICP-MS developed in the laboratory of Geochronology of the University of Brasilia and report the results obtained by repeated analyses of {sup 176}Hf/{sup 177}Hf isotopic ratio of three zircon standards: GJ-1 = 0.282022 ± 11 (n=56), Temora 2 = 0.282693 ± 14 (n=25) and UQZ = 0.282127 ± 33 (n=11). The {sup 176}Hf/{sup 177}Hf ratio (0.282352 ± 22, n=14) of gem quality zircon used as in-house standard have been also characterized. As a geological application, we analyzed two complex zircons selected from a migmatitic rocks from the Borborema Province, NE Brazil. On the basis of U-Pb and Lu-Hf data, two main crystallization events have been identified in both studied zircons. An older event at ca. 2.05 Ga recognized in the inherited cores represents a well-characterized paleoproterozoic magmatic event that affected the whole Borborema Province. A second crystallization event at ∼ 575 Ma, recognized at the rims, represents a Neoproterozoic (Brazilian) high grade metamorphic-magmatic event. (author)

  16. A methodology for understanding the impacts of large-scale penetration of micro-combined heat and power

    International Nuclear Information System (INIS)

    Tapia-Ahumada, K.; Pérez-Arriaga, I.J.; Moniz, E.J.

    2013-01-01

    Co-generation at small kW-e scale has been stimulated in recent years by governments and energy regulators as one way to increasing energy efficiency and reducing CO 2 emissions. If a widespread adoption should be realized, their effects from a system's point of view are crucial to understand the contributions of this technology. Based on a methodology that uses long-term capacity planning expansion, this paper explores some of the implications for an electric power system of having a large number of micro-CHPs. Results show that fuel cells-based micro-CHPs have the best and most consistent performance for different residential demands from the customer and system's perspectives. As the penetration increases at important levels, gas-based technologies—particularly combined cycle units—are displaced in capacity and production, which impacts the operation of the electric system during summer peak hours. Other results suggest that the tariff design impacts the economic efficiency of the system and the operation of micro-CHPs under a price-based strategy. Finally, policies aimed at micro-CHPs should consider the suitability of the technology (in size and heat-to-power ratio) to meet individual demands, the operational complexities of a large penetration, and the adequacy of the economic signals to incentivize an efficient and sustainable operation. - Highlights: • Capacity displacements and daily operation of an electric power system are explored. • Benefits depend on energy mix, prices, and micro-CHP technology and control scheme. • Benefits are observed mostly in winter when micro-CHP heat and power are fully used. • Micro-CHPs mostly displace installed capacity from natural gas combined cycle units. • Tariff design impacts economic efficiency of the system and operation of micro-CHPs

  17. A Combined Methodology to Eliminate Artifacts in Multichannel Electrogastrogram Based on Independent Component Analysis and Ensemble Empirical Mode Decomposition.

    Science.gov (United States)

    Sengottuvel, S; Khan, Pathan Fayaz; Mariyappa, N; Patel, Rajesh; Saipriya, S; Gireesan, K

    2018-06-01

    Cutaneous measurements of electrogastrogram (EGG) signals are heavily contaminated by artifacts due to cardiac activity, breathing, motion artifacts, and electrode drifts whose effective elimination remains an open problem. A common methodology is proposed by combining independent component analysis (ICA) and ensemble empirical mode decomposition (EEMD) to denoise gastric slow-wave signals in multichannel EGG data. Sixteen electrodes are fixed over the upper abdomen to measure the EGG signals under three gastric conditions, namely, preprandial, postprandial immediately, and postprandial 2 h after food for three healthy subjects and a subject with a gastric disorder. Instantaneous frequencies of intrinsic mode functions that are obtained by applying the EEMD technique are analyzed to individually identify and remove each of the artifacts. A critical investigation on the proposed ICA-EEMD method reveals its ability to provide a higher attenuation of artifacts and lower distortion than those obtained by the ICA-EMD method and conventional techniques, like bandpass and adaptive filtering. Characteristic changes in the slow-wave frequencies across the three gastric conditions could be determined from the denoised signals for all the cases. The results therefore encourage the use of the EEMD-based technique for denoising gastric signals to be used in clinical practice.

  18. Three-dimensional sensing methodology combining stereo vision and phase-measuring profilometry based on dynamic programming

    Science.gov (United States)

    Lee, Hyunki; Kim, Min Young; Moon, Jeon Il

    2017-12-01

    Phase measuring profilometry and moiré methodology have been widely applied to the three-dimensional shape measurement of target objects, because of their high measuring speed and accuracy. However, these methods suffer from inherent limitations called a correspondence problem, or 2π-ambiguity problem. Although a kind of sensing method to combine well-known stereo vision and phase measuring profilometry (PMP) technique simultaneously has been developed to overcome this problem, it still requires definite improvement for sensing speed and measurement accuracy. We propose a dynamic programming-based stereo PMP method to acquire more reliable depth information and in a relatively small time period. The proposed method efficiently fuses information from two stereo sensors in terms of phase and intensity simultaneously based on a newly defined cost function of dynamic programming. In addition, the important parameters are analyzed at the view point of the 2π-ambiguity problem and measurement accuracy. To analyze the influence of important hardware and software parameters related to the measurement performance and to verify its efficiency, accuracy, and sensing speed, a series of experimental tests were performed with various objects and sensor configurations.

  19. Postcards from the edge: Trash-2-Cash communication tools used to support inter-disciplinary work towards a design driven material innovation (DDMI) methodology

    Science.gov (United States)

    Earley, R.; Hornbuckle, R.

    2017-10-01

    In this paper postcards from the EU funded Horizon 2020 Trash-2-Cash (2015-2018) project - completed by workshop participants - are presented in three tables with a focus on how they contributed to the building of communication channels, shared understanding and methods in this inter-disciplinary consortium work. The Trash-2-Cash project aims to support better waste utilisation, improve material efficiency, contribute to reduction of landfill area needs, whilst also producing high-value commercial products. Novel materials will drive the generation of new textile fibres that will utilize paper and textile fibre waste, originating from continuously increasing textile consumption. The inter-disciplanarity of the participants is key to achieving the project aims - but communication between sectors is challenging due to diverse expertise and levels of experience; language and cultural differences can also be barriers to collaboration as well. Designing easy and accessible, even fun, communication tools are one of the ways to help build relationships. The cards reviewed were used in Prato (November 2015), Helsinki (February 2016) and London (November 2016). This paper concludes with insights for the ongoing development of the project communications work towards the Design Driven Material Innovation (DDMI) methodology, due to be presented at the end of the project in 2018.

  20. Guidance for the application of an assessment methodology for innovative nuclear energy systems. INPRO manual - Overview of the methodology. Vol. 1 of 9 of the final report of phase 1 of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) including a CD-ROM comprising all volumes

    International Nuclear Information System (INIS)

    2008-11-01

    The International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) was initiated in the year 2000, based on a resolution of the IAEA General Conference (GC(44)/RES/21). The main objectives of INPRO are (1) to help to ensure that nuclear energy is available to contribute in fulfilling energy needs in the 21st century in a sustainable manner, (2) to bring together both technology holders and technology users to consider jointly the international and national actions required to achieve desired innovations in nuclear reactors and fuel cycles; and (3) to create a forum to involve all relevant stakeholders that will have an impact on, draw from, and complement the activities of existing institutions, as well as ongoing initiatives at the national and international level. This document follows the guidelines of the INPRO report 'Methodology for the assessment of innovative nuclear reactors and fuel cycles, Report of Phase 1B (first part) of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO)', IAEA-TECDOC-1434 (2004), together with its previous report Guidance for the evaluation for innovative nuclear reactors and fuel cycles, Report of Phase 1A of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO), IAEA-TECDOC-1362 (2003). This INPRO manual is comprised of an overview volume (laid out in this report), and eight additional volumes (available on a CD-ROM attached to the inside back cover of this report) covering the areas of economics (Volume 2), infrastructure (Volume 3), waste management (Volume 4), proliferation resistance (Volume 5), physical protection (Volume 6), environment (Volume 7), safety of reactors (Volume 8), and safety of nuclear fuel cycle facilities (Volume 9). The overview volume sets out the philosophy of INPRO and a general discussion of the INPRO methodology. This overview volume discusses the relationship of INPRO with the UN concept of sustainability to demonstrate how the

  1. Fast Track Characterization of Highly Radioactive Waste Pits Combining Off-the-Shelf Robotics with Innovative Investigation Protocols

    International Nuclear Information System (INIS)

    Chabeuf, Jean-Michel; Boya, Didier

    2008-01-01

    The investigation and characterization of radioactive waste pits and effluent storage tanks represents a substantial and challenging step in the overall decommissioning programme launched by AREVA NC in 1998 on the site of Marcoule on behalf of the French Atomic Energy commission. Physical ,radiological and regulatory constraints, combined with a tight schedule, have lead our teams to use proven conventional instrumentation and robotics in innovative configurations . One such investigation, conducted on a particularly challenging radioactive effluent storage pit, is described below. The 'H' pit is a stainless steel clad concrete cavity, located in the second basement of the de-cladding building of Marcoule site. It was used for forty years as buffer storage for high activity effluents and has a length of 5 meters, a width of 3 meters , a height of 2.5 meters, and is topped by lead plates over 5 cm thick and The bottom of the cavity is covered with a layer of mud containing mainly graphite, diatoms and resins. The mud level ranges from about 20 centimeters to over 50 centimeters. The overall mud volume is around 2.4 cubic meters. Ambient dose rates above the lead plates exceed 10 mSv/h. The main purpose of our investigation was to characterize the muds for future recovery and conditioning prior to decontaminating the pit. The history of the pit together with the varying mud altimetry lead us to believe that sedimentation had probably occurred throughout the years. We thus decided to combine dose rate measurements using IF104 probes, gamma spectroscopy with CdTe probes and sample collections at different depths to ensure the representativeness and full characterization of the muds. Poor access, ambient dose rates have lead us to conceive a robotic arm, mounted on an shaft which can be modified to fit a wide range of pits and tanks. Custom built robotic tools with maximum manoeuvrability generally involve costs and delays far exceeding our purposes. SIT, a French

  2. Damage methodology approach on a composite panel based on a combination of Fringe Projection and 2D Digital Image Correlation

    Science.gov (United States)

    Felipe-Sesé, Luis; Díaz, Francisco A.

    2018-02-01

    The recent improvement in accessibility to high speed digital cameras has enabled three dimensional (3D) vibration measurements employing full-field optical techniques. Moreover, there is a need to develop a cost-effective and non-destructive testing method to quantify the severity of damages arising from impacts and thus, enhance the service life. This effect is more interesting in composite structures since possible internal damage has low external manifestation. Those possible damages have been previously studied experimentally by using vibration testing. Namely, those analyses were focused on variations in the modal frequencies or, more recently, mode shapes variations employing punctual accelerometers or vibrometers. In this paper it is presented an alternative method to investigate the severity of damage on a composite structure and how the damage affects to its integrity through the analysis of the full field modal behaviour. In this case, instead of punctual measurements, displacement maps are analysed by employing a combination of FP + 2D-DIC during vibration experiments in an industrial component. In addition, to analyse possible mode shape changes, differences between damaged and undamaged specimens are studied by employing a recent methodology based on Adaptive Image Decomposition (AGMD) procedure. It will be demonstrated that AGMD Image decomposition procedure, which decompose the displacement field into shape descriptors, is capable to detect and quantify the differences between mode shapes. As an application example, the proposed approach has been evaluated on two large industrial components (car bonnets) made of short-fibre reinforced composite. Specifically, the evolution of normalized AGMD shape descriptors has been evaluated for three different components with different damage levels. Results demonstrate the potential of the presented approach making it possible to measure the severity of a structural damage by evaluating the mode shape based in

  3. Methodological Innovations for Studying Organizations.

    Science.gov (United States)

    1981-01-01

    dynamics among artists in the Hollywood film industry . James Dabbs is a Professor of Psychology at Georgia State University. His research interests...development of careers in the Hollywood film industry . Throughout, Faulkner emphasizes the interplay between evidence from archives and documents on

  4. APRECIACIONES DE LOS ESTUDIANTES SOBRE INNOVACIONES METODOLÓGICAS EN EL INGRESO UNIVERSITARIO / STUDENTS’ APPRAISAL ABOUT METHODOLOGICAL INNOVATIONS IN UNIVERSITY ADMISSION COURSES

    Directory of Open Access Journals (Sweden)

    Aldo Daguerre

    2016-09-01

    posterior de los estudiantes. / The admission courses of the Faculty of Chemistry, Biochemistry and Pharmacy of the National University of San Luis (in Spanish UNSL implemented, from the 2015 term onwards, a series of methodological innovations: a the final eliminatory test was discarded, b a requirement of 80% of attendance to pass was included, c mandatory/ compulsory non-scored examinations were administered; d study techniques and literacy-related contents were incorporated, and d teachers took a training workshop. The aim of this work was to gain some knowledge about and analyze the perception and evaluation of these strategies by the students that attended the Biology Entrance Course through the implementation of a survey. From a total of 489 students registered, 440 (89% attended 80% or more of the classes and took two examinations. The survey results show that 87% of students considered the methodology was good/appropriate; they argued that it promoted dynamic classes and group work, and 83% of students evaluated specific Biology contents as understandable/accessible. Practice activities were mostly evaluated as useful/helpful (41% and fun (22%, and the contents about UNSL organization and literacy were considered mostly as useful. Teachers’ performance was positively evaluated, as well as examinations, where 78% of students preferred a non-eliminatory system. On the whole, the methodological innovations included in the Biology Entrance Course were positively evaluated. Most of students considered that the activities allowed them to improve or appropriate their capacities, that they changed attitudes and increased their confidence to start a university career. A later stage of analysis should evaluate the impact of these methodologies incorporated during the entrance courses on the subsequent performance of students.

  5. Guidance for the application of an assessment methodology for innovative nuclear energy systems. INPRO manual - Infrastructure. Vol. 3 of the final report of phase 1 of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO)

    International Nuclear Information System (INIS)

    2008-11-01

    The International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) was initiated in the year 2000, based on a resolution of the IAEA General Conference (GC(44)/RES/21). The main objectives of INPRO are (1) to help to ensure that nuclear energy is available to contribute in fulfilling energy needs in the 21st century in a sustainable manner, (2) to bring together both technology holders and technology users to consider jointly the international and national actions required to achieve desired innovations in nuclear reactors and fuel cycles; and (3) to create a forum to involve all relevant stakeholders that will have an impact on, draw from, and complement the activities of existing institutions, as well as ongoing initiatives at the national and international level. The INPRO manual is comprised of an overview volume and eight additional volumes covering the areas of economics (Volume 2), infrastructure (Volume 3, outlined here), waste management (Volume 4), proliferation resistance (Volume 5), physical protection (Volume 6), environment (Volume 7), safety of reactors (Volume 8), and safety of nuclear fuel cycle facilities (Volume 9). Within INPRO, the term infrastructure can be defined as the collection of capabilities of institutions involved in a nuclear power program in a given country that are necessary for the successful deployment (or enlargement) and operation of an INS, including legal and institutional, industrial and economic, and socio-political features. Within INPRO, the definition of an INS includes activities and facilities (i.e. components) at both the front end of the fuel cycle (e.g., mining, enrichment, fuel fabrication) and the back end (e.g., reprocessing, storage, and repository) (Section 4.2.1 of Volume 1 of the INPRO manual. Consequently, within INPRO, such facilities are not considered to be a part of the INPRO area of infrastructure, albeit that they influence the size of the necessary infrastructure required in a given

  6. Guidance for the application of an assessment methodology for innovative nuclear energy systems. INPRO manual - Proliferation resistance. Vol. 5 of the final report of phase 1 of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO)

    International Nuclear Information System (INIS)

    2008-11-01

    The International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) was initiated in the year 2000, based on a resolution of the IAEA General Conference (GC(44)/RES/21). The main objectives of INPRO are (1) to help to ensure that nuclear energy is available to contribute in fulfilling energy needs in the 21st century in a sustainable manner, (2) to bring together both technology holders and technology users to consider jointly the international and national actions required to achieve desired innovations in nuclear reactors and fuel cycles; and (3) to create a forum to involve all relevant stakeholders that will have an impact on, draw from, and complement the activities of existing institutions, as well as ongoing initiatives at the national and international level. The INPRO manual is comprised of an overview volume (No. 1), and eight additional volumes covering the areas of economics (Volume 2), infrastructure (Volume 3), waste management (Volume 4), proliferation resistance (laid out in this report) (Volume 5), physical protection (Volume 6), environment (Volume 7), safety of nuclear reactors (Volume 8), and safety of nuclear fuel cycle facilities (Volume 9). This volume of the INPRO manual is based on the results of an INPRO study on proliferation resistance of the DUPIC fuel cycle performed by the Republic of Korea during 2005 and 2006, recommendations from IAEA consultancy meetings, and on a special service agreement with G. Pshakin (Russian Federation). The INPRO Manual starts with an introduction in Chapter 1. In Chapter 2, the necessary information is described to perform an INPRO assessment in the area of proliferation resistance. Explanatory notes on the INPRO basic principles (BP) and user requirements (UR) in the area of proliferation resistance, are reproduced in Chapter 3 to provide context for the assessor; additionally, background of each criterion (CR) and a corresponding procedure is described how to perform an INPRO assessment. The

  7. Guidance for the application of an assessment methodology for innovative nuclear energy systems. INPRO manual - Waste management. Vol. 4 of the final report of phase 1 of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO)

    International Nuclear Information System (INIS)

    2008-11-01

    The International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) was initiated in the year 2000, based on a resolution of the IAEA General Conference (GC(44)/RES/21). The main objectives of INPRO are (1) to help to ensure that nuclear energy is available to contribute in fulfilling energy needs in the 21st century in a sustainable manner, (2) to bring together both technology holders and technology users to consider jointly the international and national actions required to achieve desired innovations in nuclear reactors and fuel cycles; and (3) to create a forum to involve all relevant stakeholders that will have an impact on, draw from, and complement the activities of existing institutions, as well as ongoing initiatives at the national and international level. The INPRO manual is comprised of an overview volume (No. 1), and eight additional volumes covering the areas of economics (Volume 2), infrastructure (Volume 3), waste management (Volume 4), proliferation resistance (laid out in this report) (Volume 5), physical protection (Volume 6), environment (Volume 7), safety of nuclear reactors (Volume 8), and safety of nuclear fuel cycle facilities (Volume 9). This volume of the INPRO manual is based on the results of an INPRO study on proliferation resistance of the DUPIC fuel cycle performed by the Republic of Korea during 2005 and 2006, recommendations from IAEA consultancy meetings, and on a special service agreement with G. Pshakin (Russian Federation). The INPRO Manual starts with an introduction in Chapter 1. In Chapter 2, the necessary information is described to perform an INPRO assessment in the area of proliferation resistance. Explanatory notes on the INPRO basic principles (BP) and user requirements (UR) in the area of proliferation resistance, are reproduced in Chapter 3 to provide context for the assessor; additionally, background of each criterion (CR) and a corresponding procedure is described how to perform an INPRO assessment. The

  8. Everyday Innovation

    DEFF Research Database (Denmark)

    Lippke, Lena; Wegener, Charlotte

    2014-01-01

    Purpose – The purpose of this paper is to explore how vocational teachers’ everyday practices can constitute innovative learning spaces that help students to experience engagement and commitment towards education and thus increase their possibilities for completing their studies despite notable...... difficulties. Design/methodology/approach – Based on two ethnographic field studies, we analyse vocational teaching situations in which teachers and students engage in daily remaking of the vocational educational training practice. It is argued that these everyday situations can be understood as innovative....... Practical implications – Based on the analysis, we argue that students’ engagement in education can be enhanced by transforming the educational settings on various parameters such as buildings, artefacts, emotions and experiences. Thus, innovation should be recognised as emerging everyday activities...

  9. Winning Combinations

    DEFF Research Database (Denmark)

    Criscuolo, Paola; Laursen, Keld; Reichstein, Toke

    2018-01-01

    examine the effectiveness of different combinations of knowledge sources for achieving innovative performance. We suggest that combinations involving integrative search strategies – combining internal and external knowledge – are the most likely to generate product and process innovation. In this context......, we present the idea that cognitively distant knowledge sources are helpful for innovation only when used in conjunction with knowledge sources that are closer to the focal firm. We also find important differences between product and process innovation, with the former associated with broader searches......Searching for the most rewarding sources of innovative ideas remains a key challenge in management of technological innovation. Yet, little is known about which combinations of internal and external knowledge sources are triggers for innovation. Extending theories about searching for innovation, we...

  10. Methodology applied to develop the DHIE: applied methodology

    CSIR Research Space (South Africa)

    Herselman, Marlien

    2016-12-01

    Full Text Available This section will address the methodology that was applied to develop the South African Digital Health Innovation Ecosystem (DHIE). Each chapter under Section B represents a specific phase in the methodology....

  11. A Combined Methodology for Landslide Risk Mitigation in Basilicata Region by Using LIDAR Technique and Rockfall Simulation

    Directory of Open Access Journals (Sweden)

    G. Colangelo

    2011-01-01

    Full Text Available Rockfalls represent a significant geohazards along the SS18 road of Basilicata Region, Italy. The management of these rockfall hazards and the mitigation of the risk require innovative approaches and technologies. This paper discusses a hazard assessment strategy and risk mitigation for rockfalls in a section of SS118, along the coast of Maratea, using LIDAR technique and spatial modelling. Historical rockfall records were used to calibrate the physical characteristics of the rockfall processes. The results of the simulations were used to define the intervention actions and engineering strategy for the mitigation of the phenomena. Within two months, 260 linear meters of high-energy rockfall barriers for impact energies up to 3000 kJ were installed. After that, according to road authority, the SS18 road was opened in a safe condition. The results represent a valid cognitive support to choose the most appropriate technical solution for topography strengthening and an example of good practice for the cooperation between innovative technologies and field emergency management.

  12. [Optimization of Polysaccharide Extraction from Spirodela polyrrhiza by Plackett-Burman Design Combined with Box-Behnken Response Surface Methodology].

    Science.gov (United States)

    Jiang, Zheng; Wang, Hong; Wu, Qi-nan

    2015-06-01

    To optimize the processing of polysaccharide extraction from Spirodela polyrrhiza. Five factors related to extraction rate of polysaccharide were optimized by the Plackett-Burman design. Based on this study, three factors, including alcohol volume fraction, extraction temperature and ratio of material to liquid, were regarded as investigation factors by Box-Behnken response surface methodology. The effect order of three factors on the extraction rate of polysaccharide from Spirodela polyrrhiza were as follows: extraction temperature, alcohol volume fraction,ratio of material to liquid. According to Box-Behnken response, the best extraction conditions were: alcohol volume fraction of 81%, ratio of material to liquid of 1:42, extraction temperature of 100 degrees C, extraction time of 60 min for four times. Plackett-Burman design and Box-Behnken response surface methodology used to optimize the extraction process for the polysaccharide in this study is effective and stable.

  13. Methodology for the optimal design of an integrated first and second generation ethanol production plant combined with power cogeneration.

    Science.gov (United States)

    Bechara, Rami; Gomez, Adrien; Saint-Antonin, Valérie; Schweitzer, Jean-Marc; Maréchal, François

    2016-08-01

    The application of methodologies for the optimal design of integrated processes has seen increased interest in literature. This article builds on previous works and applies a systematic methodology to an integrated first and second generation ethanol production plant with power cogeneration. The methodology breaks into process simulation, heat integration, thermo-economic evaluation, exergy efficiency vs. capital costs, multi-variable, evolutionary optimization, and process selection via profitability maximization. Optimization generated Pareto solutions with exergy efficiency ranging between 39.2% and 44.4% and capital costs from 210M$ to 390M$. The Net Present Value was positive for only two scenarios and for low efficiency, low hydrolysis points. The minimum cellulosic ethanol selling price was sought to obtain a maximum NPV of zero for high efficiency, high hydrolysis alternatives. The obtained optimal configuration presented maximum exergy efficiency, hydrolyzed bagasse fraction, capital costs and ethanol production rate, and minimum cooling water consumption and power production rate. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. Characterization of chlorinated solvent contamination in limestone using innovative FLUTe® technologies in combination with other methods in a line of evidence approach

    DEFF Research Database (Denmark)

    Broholm, Mette Martina; Janniche, Gry Sander; Mosthaf, Klaus

    2016-01-01

    Characterization of dense non-aqueous phase liquid (DNAPL) source zones in limestone aquifers/bedrock is essential to develop accurate site-specific conceptual models and perform risk assessment. Here innovative field methods were combined to improve determination of source zone architecture......, hydrogeology and contaminant distribution. The FACT™ is a new technology and it was applied and tested at a contaminated site with a limestone aquifer, together with a number of existing methods including wire-line coring with core subsampling, FLUTe® transmissivity profiling and multilevel water sampling...... groundwater sampling (under two flow conditions) and FACT™ sampling and analysis combined with FLUTe® transmissivity profiling and modeling were used to provide a line of evidence for the presence of DNAPL, dissolved and sorbed phase contamination in the limestone fractures and matrix. The combined methods...

  15. Activity of daptomycin alone and in combination with rifampin and gentamicin against Staphylococcus aureus assessed by time-kill methodology.

    Science.gov (United States)

    Credito, Kim; Lin, Gengrong; Appelbaum, Peter C

    2007-04-01

    The synergistic effects of daptomycin plus gentamicin or rifampin were tested against 50 Staphylococcus aureus strains, with daptomycin MICs ranging between 0.25 and 8 microg/ml. Daptomycin sub-MICs combined with gentamicin concentrations lower than the MIC yielded synergy in 34 (68%) of the 50 strains. Daptomycin combined with rifampin yielded synergy in one vancomycin-intermediate S. aureus strain only, and virtually all synergy occurred between daptomycin and gentamicin.

  16. Combining history of medicine and library instruction: an innovative approach to teaching database searching to medical students.

    Science.gov (United States)

    Timm, Donna F; Jones, Dee; Woodson, Deidra; Cyrus, John W

    2012-01-01

    Library faculty members at the Health Sciences Library at the LSU Health Shreveport campus offer a database searching class for third-year medical students during their surgery rotation. For a number of years, students completed "ten-minute clinical challenges," but the instructors decided to replace the clinical challenges with innovative exercises using The Edwin Smith Surgical Papyrus to emphasize concepts learned. The Surgical Papyrus is an online resource that is part of the National Library of Medicine's "Turning the Pages" digital initiative. In addition, vintage surgical instruments and historic books are displayed in the classroom to enhance the learning experience.

  17. A Combined Methodology of Adaptive Neuro-Fuzzy Inference System and Genetic Algorithm for Short-term Energy Forecasting

    Directory of Open Access Journals (Sweden)

    KAMPOUROPOULOS, K.

    2014-02-01

    Full Text Available This document presents an energy forecast methodology using Adaptive Neuro-Fuzzy Inference System (ANFIS and Genetic Algorithms (GA. The GA has been used for the selection of the training inputs of the ANFIS in order to minimize the training result error. The presented algorithm has been installed and it is being operating in an automotive manufacturing plant. It periodically communicates with the plant to obtain new information and update the database in order to improve its training results. Finally the obtained results of the algorithm are used in order to provide a short-term load forecasting for the different modeled consumption processes.

  18. [Optimization of process of icraiin be hydrolyzed to Baohuoside I by cellulase based on Plackett-Burman design combined with CCD response surface methodology].

    Science.gov (United States)

    Song, Chuan-xia; Chen, Hong-mei; Dai, Yu; Kang, Min; Hu, Jia; Deng, Yun

    2014-11-01

    To optimize the process of Icraiin be hydrolyzed to Baohuoside I by cellulase by Plackett-Burman design combined with Central Composite Design (CCD) response surface methodology. To select the main influencing factors by Plackett-Burman design, using CCD response surface methodology to optimize the process of Icraiin be hydrolyzed to Baohuoside I by cellulase. Taking substrate concentration, the pH of buffer and reaction time as independent variables, with conversion rate of icariin as dependent variable,using regression fitting of completely quadratic response surface between independent variable and dependent variable,the optimum process of Icraiin be hydrolyzed to Baohuoside I by cellulase was intuitively analyzed by 3D surface chart, and taking verification tests and predictive analysis. The best enzymatic hydrolytic process was as following: substrate concentration 8. 23 mg/mL, pH 5. 12 of buffer,reaction time 35. 34 h. The optimum process of Icraiin be hydrolyzed to Baohuoside I by cellulase is determined by Plackett-Burman design combined with CCD response surface methodology. The optimized enzymatic hydrolytic process is simple, convenient, accurate, reproducible and predictable.

  19. A cloud mask methodology for high resolution remote sensing data combining information from high and medium resolution optical sensors

    Science.gov (United States)

    Sedano, Fernando; Kempeneers, Pieter; Strobl, Peter; Kucera, Jan; Vogt, Peter; Seebach, Lucia; San-Miguel-Ayanz, Jesús

    2011-09-01

    This study presents a novel cloud masking approach for high resolution remote sensing images in the context of land cover mapping. As an advantage to traditional methods, the approach does not rely on thermal bands and it is applicable to images from most high resolution earth observation remote sensing sensors. The methodology couples pixel-based seed identification and object-based region growing. The seed identification stage relies on pixel value comparison between high resolution images and cloud free composites at lower spatial resolution from almost simultaneously acquired dates. The methodology was tested taking SPOT4-HRVIR, SPOT5-HRG and IRS-LISS III as high resolution images and cloud free MODIS composites as reference images. The selected scenes included a wide range of cloud types and surface features. The resulting cloud masks were evaluated through visual comparison. They were also compared with ad-hoc independently generated cloud masks and with the automatic cloud cover assessment algorithm (ACCA). In general the results showed an agreement in detected clouds higher than 95% for clouds larger than 50 ha. The approach produced consistent results identifying and mapping clouds of different type and size over various land surfaces including natural vegetation, agriculture land, built-up areas, water bodies and snow.

  20. Combining Behavioral and ERP Methodologies to Investigate the Differences Between McGurk Effects Demonstrated by Cantonese and Mandarin Speakers

    Directory of Open Access Journals (Sweden)

    Juan Zhang

    2018-05-01

    Full Text Available The present study investigated the impact of Chinese dialects on McGurk effect using behavioral and event-related potential (ERP methodologies. Specifically, intra-language comparison of McGurk effect was conducted between Mandarin and Cantonese speakers. The behavioral results showed that Cantonese speakers exhibited a stronger McGurk effect in audiovisual speech perception compared to Mandarin speakers, although both groups performed equally in the auditory and visual conditions. ERP results revealed that Cantonese speakers were more sensitive to visual cues than Mandarin speakers, though this was not the case for the auditory cues. Taken together, the current findings suggest that the McGurk effect generated by Chinese speakers is mainly influenced by segmental phonology during audiovisual speech integration.

  1. Combining Behavioral and ERP Methodologies to Investigate the Differences Between McGurk Effects Demonstrated by Cantonese and Mandarin Speakers

    Science.gov (United States)

    Zhang, Juan; Meng, Yaxuan; McBride, Catherine; Fan, Xitao; Yuan, Zhen

    2018-01-01

    The present study investigated the impact of Chinese dialects on McGurk effect using behavioral and event-related potential (ERP) methodologies. Specifically, intra-language comparison of McGurk effect was conducted between Mandarin and Cantonese speakers. The behavioral results showed that Cantonese speakers exhibited a stronger McGurk effect in audiovisual speech perception compared to Mandarin speakers, although both groups performed equally in the auditory and visual conditions. ERP results revealed that Cantonese speakers were more sensitive to visual cues than Mandarin speakers, though this was not the case for the auditory cues. Taken together, the current findings suggest that the McGurk effect generated by Chinese speakers is mainly influenced by segmental phonology during audiovisual speech integration. PMID:29780312

  2. Combining tracer flux ratio methodology with low-flying aircraft measurements to estimate dairy farm CH4 emissions

    Science.gov (United States)

    Daube, C.; Conley, S.; Faloona, I. C.; Yacovitch, T. I.; Roscioli, J. R.; Morris, M.; Curry, J.; Arndt, C.; Herndon, S. C.

    2017-12-01

    Livestock activity, enteric fermentation of feed and anaerobic digestion of waste, contributes significantly to the methane budget of the United States (EPA, 2016). Studies question the reported magnitude of these methane sources (Miller et. al., 2013), calling for more detailed research of agricultural animals (Hristov, 2014). Tracer flux ratio is an attractive experimental method to bring to this problem because it does not rely on estimates of atmospheric dispersion. Collection of data occurred during one week at two dairy farms in central California (June, 2016). Each farm varied in size, layout, head count, and general operation. The tracer flux ratio method involves releasing ethane on-site with a known flow rate to serve as a tracer gas. Downwind mixed enhancements in ethane (from the tracer) and methane (from the dairy) were measured, and their ratio used to infer the unknown methane emission rate from the farm. An instrumented van drove transects downwind of each farm on public roads while tracer gases were released on-site, employing the tracer flux ratio methodology to assess simultaneous methane and tracer gas plumes. Flying circles around each farm, a small instrumented aircraft made measurements to perform a mass balance evaluation of methane gas. In the course of these two different methane quantification techniques, we were able to validate yet a third method: tracer flux ratio measured via aircraft. Ground-based tracer release rates were applied to the aircraft-observed methane-to-ethane ratios, yielding whole-site methane emission rates. Never before has the tracer flux ratio method been executed with aircraft measurements. Estimates from this new application closely resemble results from the standard ground-based technique to within their respective uncertainties. Incorporating this new dimension to the tracer flux ratio methodology provides additional context for local plume dynamics and validation of both ground and flight-based data.

  3. Dried Blood Spot Methodology in Combination With Liquid Chromatography/Tandem Mass Spectrometry Facilitates the Monitoring of Teriflunomide

    Science.gov (United States)

    Lunven, Catherine; Turpault, Sandrine; Beyer, Yann-Joel; O'Brien, Amy; Delfolie, Astrid; Boyanova, Neli; Sanderink, Ger-Jan; Baldinetti, Francesca

    2016-01-01

    Background: Teriflunomide, a once-daily oral immunomodulator approved for treatment of relapsing-remitting multiple sclerosis, is eliminated slowly from plasma. If necessary to rapidly lower plasma concentrations of teriflunomide, an accelerated elimination procedure using cholestyramine or activated charcoal may be used. The current bioanalytical assay for determination of plasma teriflunomide concentration requires laboratory facilities for blood centrifugation and plasma storage. An alternative method, with potential for greater convenience, is dried blood spot (DBS) methodology. Analytical and clinical validations are required to switch from plasma to DBS (finger-prick sampling) methodology. Methods: Using blood samples from healthy subjects, an LC-MS/MS assay method for quantification of teriflunomide in DBS over a range of 0.01–10 mcg/mL was developed and validated for specificity, selectivity, accuracy, precision, reproducibility, and stability. Results were compared with those from the current plasma assay for determination of plasma teriflunomide concentration. Results: Method was specific and selective relative to endogenous compounds, with process efficiency ∼88%, and no matrix effect. Inaccuracy and imprecision for intraday and interday analyses were blood deposit volume and punch position within spot, and hematocrit level had a limited but acceptable effect on measurement accuracy. Teriflunomide was stable for at least 4 months at room temperature, and for at least 24 hours at 37°C with and without 95% relative humidity, to cover sampling, drying, and shipment conditions in the field. The correlation between DBS and plasma concentrations (R2 = 0.97), with an average blood to plasma ratio of 0.59, was concentration independent and constant over time. Conclusions: DBS sampling is a simple and practical method for monitoring teriflunomide concentrations. PMID:27015245

  4. Action Reflected and Project Based Combined Methodology for the Appropriate Comprehension of Mechanisms in Industrial Design Education

    Science.gov (United States)

    Yavuzcan, H. Güçlü; Sahin, Damla

    2017-01-01

    In industrial design (ID) education, mechanics-based courses are mainly based on a traditional lecture approach and they are highly abstract for ID students to comprehend. The existing studies highlight the requirement of a new approach for mechanics-based courses in ID departments. This study presents a combined teaching model for mechanisms…

  5. A methodology for translating positional error into measures of attribute error, and combining the two error sources

    Science.gov (United States)

    Yohay Carmel; Curtis Flather; Denis Dean

    2006-01-01

    This paper summarizes our efforts to investigate the nature, behavior, and implications of positional error and attribute error in spatiotemporal datasets. Estimating the combined influence of these errors on map analysis has been hindered by the fact that these two error types are traditionally expressed in different units (distance units, and categorical units,...

  6. Undergraduate physics course innovations and their impact on student learning

    Science.gov (United States)

    Iverson, Heidi Louise

    Over the last several decades, the efficacy of the traditional lecture-based instructional model for undergraduate physics courses has been challenged. As a result, a large number of reform-oriented instructional innovations have been developed, enacted, and studied in undergraduate physics courses around the globe---all with the intended purpose of improving student learning. This thesis satisfies the need for a comprehensive synthesis of the effectiveness of these course innovations by analyzing: (1) the types of innovations that have been enacted, (2) the impact of these innovations on student learning, and (3) the common features of effective innovations. An exhaustive literature search for studies published after 1990 on undergraduate physics course innovations yielded 432 articles which were then coded with respect to the characteristics of the innovations used as well as the methodological characteristics of the studies. These codes facilitated a descriptive analysis which characterized the features of the pool of studies. These studies were then meta-analyzed in order to evaluate the effect of innovations on student learning. Finally, a case-study analysis was conducted in order to identify the critical characteristics of effective innovations. Results indicate that most innovations focus on introductory mechanics and use some combination of conceptually oriented tasks, collaborative learning, and technology. The overall effect of course innovations has been positive, but with the caveat that a large number of studies suffer from poor methodological designs and potential threats to validity. In addition, over half of the studies had to be eliminated from the meta-analysis because they did not report the data necessary for an effect size to be calculated. Despite these limitations the results of the meta-analysis indicated that there was one innovation which had particularly high effect sizes---Workshop/Studio Physics---an innovation which involves an

  7. Cultural Dimensions of Digital Library Development, Part I: Theory and Methodological Framework for a Comparative Study of the Cultures of Innovation in Five European National Libraries

    Science.gov (United States)

    Dalbello, Marija

    2008-01-01

    This study examines the influence of culture on digital libraries of the first wave. The local cultures of innovation of five European national libraries (Biblioteca nacional de Portugal, Bibliotheque nationale de France, Die Deutsche Bibliothek, the National Library of Scotland, and the British Library) are reconstructed in case histories from…

  8. Innovation without Design?

    DEFF Research Database (Denmark)

    Pinheiro-Croisel, Rebecca; Hernes, Tor

    2012-01-01

    This paper explores innovation and social behaviourist theory in relation to sustainable urban projects in the highly institutionalized public sector (towns). Using empirical data from France, we examine the dynamics of a design process in which unexpected practices generated innovative urban...... into a movement of collective action, which presupposed the acquisition of a new identity. Ultimately, our objective is to combine social behaviourist theory and innovation theory and to facilitate innovative design in urban projects....

  9. Strategic marketing of innovations in the cosmetic market

    Directory of Open Access Journals (Sweden)

    O. S. Laskina

    2016-01-01

    Full Text Available The article is discusses the scientific and theoretical approaches to marketing of innovations in the cosmetic market in the strategic aspect. It is showing the development of the concept of strategic marketing innovation in the foreign and domestic scientific literature; the key concepts of marketing innovations is clarified; elements of the commercialization of innovative products is identified; the specificity of strategic marketing innovations in the cosmetic market in the Russian conditions is established; actual problems of innovative development and commercialization of innovations is identified; an assessment of the Russian market of innovations. The marketing of innovations – is a systematic methodological approach that combines the strategy and tactics of promotion goods (works, services, technologies, having substantially new properties, at the level of economic entities, it is proved. Under the innovative products offered to understand the implementation of the results of scientific and technological activities in the form of goods, works and services, which have an absolute or relative scientific and technological novelty and (or consumer value, going beyond the existing traditions. Innovative production is subdivided into two main categories: not commercialized and the commercialized production. Process of commercialization of innovative goods is considered as three-level system: the first level is the state innovation policy (macro-level; the second level – regional innovation policy (meso-level; the third level – commodity innovative policy of enterprise (micro-level. It was shown that the weak spots for Russian manufacturers of innovative products has been and remains insufficient elaboration of organizational and methodological approaches to strategic marketing of innovations in industry the as aspect, including in the sector of cosmetic goods. Recommendations for the development of marketing strategy of innovation

  10. An Innovative Application of a Solar Storage Wall Combined with the Low-Temperature Organic Rankine Cycle

    Directory of Open Access Journals (Sweden)

    Tzu-Chen Hung

    2014-01-01

    Full Text Available The objective of this study is to collect energy on the waste heat from air produced by solar ventilation systems. This heat used for electricity generation by an organic Rankine cycle (ORC system was implemented. The advantages of this method include the use of existing building’s wall, and it also provides the region of energy scarcity for reference. This is also an innovative method, and the results will contribute to the efforts made toward improving the design of solar ventilation in the field of solar thermal engineering. In addition, ORC system would help generate electricity and build a low-carbon building. This study considered several critical parameters such as length of the airflow channel, intensity of solar radiation, pattern of the absorber plate, stagnant air layer, and operating conditions. The simulation results show that the highest outlet temperature and heat collecting efficiency of solar ventilation system are about 120°C and 60%, respectively. The measured ORC efficiency of the system was 6.2%. The proposed method is feasible for the waste heat from air produced by ventilation systems.

  11. Examining Change in Metacognitive Knowledge and Metacognitive Control During Motor Learning: What Can be Learned by Combining Methodological Approaches?

    Directory of Open Access Journals (Sweden)

    Claire Sangster Jokić

    2014-04-01

    Full Text Available Growing recognition of the importance of understanding metacognitive behaviour as it occurs in everyday learning situations has prompted an expansion of the methodological approaches used to examine metacognition. This becomes especially pertinent when examining the process of metacognitive change, where 'on-line' observational approaches able to capture metacognitive performance as it occurs during socially-mediated learning are being increasingly applied. This study applied a mixed methods approach to examine children's metacognitive performance as it was exhibited during participation in an intervention program aimed at addressing motor performance difficulties. Participants in the study were ten 7-9 year old children with developmental coordination disorder (DCD, a condition characterized by poor motor coordination and difficulty acquiring motor-based tasks. All participants engaged in a 10-session program in which children were taught to use a problem-solving strategy for addressing motor performance difficulties. To examine children's metacognitive performance, sessions were video-taped and subsequently analysed using a quantitative observational coding method and an in-depth qualitative review of therapist-child interactions. This allowed for a fine-grained analysis of children's demonstration of metacognitive knowledge and control and how such performance evolved over the course of the program. Of particular interest was the finding that while children were often able to express task-specific knowledge, they failed to apply this knowledge during practice. Conversely, children were often able to demonstrate performance-based evidence for metacognitive control but were not able to make conscious reports of such skill following practice. This finding is consistent with models of metacognitive development which suggest that the emergence of performance-based metacognitive skills precede the ability for the conscious expression of

  12. Learning from doing: the case for combining normalisation process theory and participatory learning and action research methodology for primary healthcare implementation research.

    Science.gov (United States)

    de Brún, Tomas; O'Reilly-de Brún, Mary; O'Donnell, Catherine A; MacFarlane, Anne

    2016-08-03

    The implementation of research findings is not a straightforward matter. There are substantive and recognised gaps in the process of translating research findings into practice and policy. In order to overcome some of these translational difficulties, a number of strategies have been proposed for researchers. These include greater use of theoretical approaches in research focused on implementation, and use of a wider range of research methods appropriate to policy questions and the wider social context in which they are placed. However, questions remain about how to combine theory and method in implementation research. In this paper, we respond to these proposals. Focussing on a contemporary social theory, Normalisation Process Theory, and a participatory research methodology, Participatory Learning and Action, we discuss the potential of their combined use for implementation research. We note ways in which Normalisation Process Theory and Participatory Learning and Action are congruent and may therefore be used as heuristic devices to explore, better understand and support implementation. We also provide examples of their use in our own research programme about community involvement in primary healthcare. Normalisation Process Theory alone has, to date, offered useful explanations for the success or otherwise of implementation projects post-implementation. We argue that Normalisation Process Theory can also be used to prospectively support implementation journeys. Furthermore, Normalisation Process Theory and Participatory Learning and Action can be used together so that interventions to support implementation work are devised and enacted with the expertise of key stakeholders. We propose that the specific combination of this theory and methodology possesses the potential, because of their combined heuristic force, to offer a more effective means of supporting implementation projects than either one might do on its own, and of providing deeper understandings of

  13. Science Is Indispensable to Frugal Innovations

    Directory of Open Access Journals (Sweden)

    Balkrishna C. Rao

    2018-04-01

    Full Text Available In recent years, frugal innovations have become widely popular due to their no-frills nature that entails lower costs. However, most of the frugal innovations, at least at the grassroots level, are makeshift contraptions, made from indigenous ingenuity, that achieve their goals under constraints on various resources but may suffer from limited lifespans due to premature failure. Consequently, it is imperative that sound scientific principles not be overlooked or haphazardly applied in realizing these innovations, irrespective of their grassroots or sophisticated nature. This article therefore argues for the need to use science, sometimes at the cutting edge, to realize grassroots and advanced frugal innovations that are not prone to failure under various working conditions. In so doing, this work advocates the use of classical and new design methodologies that are rooted in science to save resources and, hence lower costs, while aiming for robust functionality of frugal products. In particular, a frugal design approach using a modern version of the safety factor called the “factor of frugality” has been propounded to effectively create any type of frugal innovation from scratch. By combining the ingenuity of the resourceful creators of frugal innovations with a scientific approach that aims to make the resulting products “fail proof”, such innovations may better contribute value to business and benefits to society.

  14. T and D-Bench--Innovative Combined Support for Education and Research in Computer Architecture and Embedded Systems

    Science.gov (United States)

    Soares, S. N.; Wagner, F. R.

    2011-01-01

    Teaching and Design Workbench (T&D-Bench) is a framework aimed at education and research in the areas of computer architecture and embedded systems. It includes a set of features not found in other educational environments. This set of features is the result of an original combination of design requirements for T&D-Bench: that the…

  15. Assessment of the innovative quality of agomelatine through the Innovation Assessment Algorithm

    Directory of Open Access Journals (Sweden)

    Liliana Civalleri

    2012-09-01

    Full Text Available Aim: the aim of this study was to assess the innovative quality of a medicine based on agomelatine, authorized by the European Commission through a centralized procedure on 19th February 2009 and distributed in Italy under the brands Valdoxan® and Thymanax®.Methodology: the degree of innovation of agomelatine was determined through the Innovation Assessment Algorithm (IAA, which considers the innovative quality of a medicine as a combination of multiple properties. The algorithm may be represented as a decision tree, with each branch corresponding to a property connected with innovation and having a fixed numerical value. The sum of these values establishes the degree of innovation of the medicine. The IAA is articulated in two phases: the first assesses the efficacy of the drug based on the clinical trials presented in support of the registration application (IAA-efficacy; the second reconsiders the degree of innovation on the basis of the efficacy and safety data resulting from clinical practice once the drug has been placed on the market (IAA-effectiveness.Results and conclusions: the score obtained for agomelatine was 592.73 in the efficacy phase and 291.3 in the effectiveness phase. The total score for the two phases was 884, which is equivalent to a good degree of innovation for the molecule

  16. AUDIT OF INNOVATIVE IDEAS AS THE PREVIOUS STAGE OF THE BUSINESS-PLAN OF START-UP PROJECTS

    OpenAIRE

    O. Zhylinska; M. Chuiko

    2014-01-01

    The phenomenon of feasibility reasoning of venture capital investment for the implementation of innovative ideas is revealed. The main elements of the methodology for feasibility of start-up projects, based on the concept of combination of life cycle of the market, product innovation and startup companies, are characterized. The comparative analysis of methods feasibility study and business plan start-up project is made, the importance of innovative ideas audit in future economic information ...

  17. New methodology to investigate potential contaminant mass fluxes at the stream-aquifer interface by combining integral pumping tests and streambed temperatures

    International Nuclear Information System (INIS)

    Kalbus, E.; Schmidt, C.; Bayer-Raich, M.; Leschik, S.; Reinstorf, F.; Balcke, G.U.; Schirmer, M.

    2007-01-01

    The spatial pattern and magnitude of mass fluxes at the stream-aquifer interface have important implications for the fate and transport of contaminants in river basins. Integral pumping tests were performed to quantify average concentrations of chlorinated benzenes in an unconfined aquifer partially penetrated by a stream. Four pumping wells were operated simultaneously for a time period of 5 days and sampled for contaminant concentrations. Streambed temperatures were mapped at multiple depths along a 60 m long stream reach to identify the spatial patterns of groundwater discharge and to quantify water fluxes at the stream-aquifer interface. The combined interpretation of the results showed average potential contaminant mass fluxes from the aquifer to the stream of 272 μg m -2 d -1 MCB and 71 μg m -2 d -1 DCB, respectively. This methodology combines a large-scale assessment of aquifer contamination with a high-resolution survey of groundwater discharge zones to estimate contaminant mass fluxes between aquifer and stream. - We provide a new methodology to quantify the potential contaminant mass flux from an aquifer to a stream

  18. Innovation in practice, dialogue

    DEFF Research Database (Denmark)

    Reinhard, CarrieLynn D.

    Presentation at the March 19, 2010 project meeting for the Virtual Worlds Research Group.  This presentation is the first report of research conducted in June, 2009, in how the Danish firm Innovation Lab makes sense of innovation as it relates to virtual world technologies.  The method used in th...... in this study was the focus group, modified using Dervin's Sense-Making Methodology.  This presentation focuses on how the members of Innovation Lab defined what is innovation, with discussion on whether or not having a unified definition within the organization makes the most sense....

  19. Mark my Words: The Design of an Innovative Methodology to Detect and Analyze Interpersonal Health Conversations in Web and Social Media

    NARCIS (Netherlands)

    Bouman, M.P.A.; Drossaert, Constance H.C.; Pieterse, Marcel E.

    2012-01-01

    Internet technology in which social media play a central role offers new opportunities for health communication. The Center for Media & Health (CMH) in the Netherlands in collaboration with the University of Twente developed a methodology called Mark My Words (MMW) to detect and monitor

  20. A methodology for combining multiple commercial data sources to improve measurement of the food and alcohol environment: applications of geographical information systems

    Directory of Open Access Journals (Sweden)

    Dara D. Mendez

    2014-11-01

    Full Text Available Commercial data sources have been increasingly used to measure and locate community resources. We describe a methodology for combining and comparing the differences in commercial data of the food and alcohol environment. We used commercial data from two commercial databases (InfoUSA and Dun&Bradstreet for 2003 and 2009 to obtain infor- mation on food and alcohol establishments and developed a matching process using computer algorithms and manual review by applying ArcGIS to geocode addresses, standard industrial classification and North American industry classification tax- onomy for type of establishment and establishment name. We constructed population and area-based density measures (e.g. grocery stores and assessed differences across data sources and used ArcGIS to map the densities. The matching process resulted in 8,705 and 7,078 unique establishments for 2003 and 2009, respectively. There were more establishments cap- tured in the combined dataset than relying on one data source alone, and the additional establishments captured ranged from 1,255 to 2,752 in 2009. The correlations for the density measures between the two data sources was highest for alcohol out- lets (r = 0.75 and 0.79 for per capita and area, respectively and lowest for grocery stores/supermarkets (r = 0.32 for both. This process for applying geographical information systems to combine multiple commercial data sources and develop meas- ures of the food and alcohol environment captured more establishments than relying on one data source alone. This replic- able methodology was found to be useful for understanding the food and alcohol environment when local or public data are limited.

  1. Utilizing Combined Methodologies to Define the Role of Plasma Membrane Delivery During Axon Branching and Neuronal Morphogenesis.

    Science.gov (United States)

    Winkle, Cortney C; Hanlin, Christopher C; Gupton, Stephanie L

    2016-03-16

    During neural development, growing axons extend to multiple synaptic partners by elaborating axonal branches. Axon branching is promoted by extracellular guidance cues like netrin-1 and results in dramatic increases to the surface area of the axonal plasma membrane. Netrin-1-dependent axon branching likely involves temporal and spatial control of plasma membrane expansion, the components of which are supplied through exocytic vesicle fusion. These fusion events are preceded by formation of SNARE complexes, comprising a v-SNARE, such as VAMP2 (vesicle-associated membrane protein 2), and plasma membrane t-SNAREs, syntaxin-1 and SNAP25 (synaptosomal-associated protein 25). Detailed herein isa multi-pronged approach used to examine the role of SNARE mediated exocytosis in axon branching. The strength of the combined approach is data acquisition at a range of spatial and temporal resolutions, spanning from the dynamics of single vesicle fusion events in individual neurons to SNARE complex formation and axon branching in populations of cultured neurons. This protocol takes advantage of established biochemical approaches to assay levels of endogenous SNARE complexes and Total Internal Reflection Fluorescence (TIRF) microscopy of cortical neurons expressing VAMP2 tagged with a pH-sensitive GFP (VAMP2-pHlourin) to identify netrin-1 dependent changes in exocytic activity in individual neurons. To elucidate the timing of netrin-1-dependent branching, time-lapse differential interference contrast (DIC) microscopy of single neurons over the order of hours is utilized. Fixed cell immunofluorescence paired with botulinum neurotoxins that cleave SNARE machinery and block exocytosis demonstrates that netrin-1 dependent axon branching requires SNARE-mediated exocytic activity.

  2. Cloud point extraction-fluorimetric combined methodology for the determination of trace warfarin based on the sensitization effect of supramolecule

    Energy Technology Data Exchange (ETDEWEB)

    Chang Zheng [Department of Applied Chemistry of College of Science, Xi' an University of Technology, Xi' an 710048 (China); College of Chemistry and Materials Science, Northwest University, 229 North Taibai Road, Xi' an 710069 (China); Yan Hongtao, E-mail: cz610@163.com [College of Chemistry and Materials Science, Northwest University, 229 North Taibai Road, Xi' an 710069 (China)

    2012-03-15

    Compared to the fluorescence spectra of warfarin in pure ethanol and in the presence of the nonionic surfactant Tergitol 15-S-7 after cloud point extraction (CPE), it can be seen that the fluorescence emission peak underwent an obvious red shift and the fluorescence intensity of warfarin was significantly increased in the presence of Tergitol 15-S-7. In order to confirm Tergitol 15-S-7-induced supramolecular effects, the investigations on the fluorescence quantum yields of warfarin in the micellar medium and pure ethanol were performed. The experimental results showed that the supramolecular interactions between Tergitol 15-S-7 and the warfarin excimers played a key role for improving the warfarin fluorescence properties. Based on these facts, a simple fluorometric method combined with CPE for the determination of trace warfarin was developed for the first time. Under optimized experimental conditions, the linear concentration range for warfarin was 3.0 Multiplication-Sign 1.0{sup -9}-1.0 Multiplication-Sign 10{sup -6} mol L{sup -1} and the detection limit was 3.3 Multiplication-Sign 10{sup -10} mol L{sup -1}. And, the proposed method was approved to be appropriate for monitoring warfarin in actual pharmaceutical formulations and biological fluid samples by recovery test, in comparison with other reported methods being satisfactory. - Highlights: Black-Right-Pointing-Pointer A CPE fluorescence method for trace warfarin was developed for the first time. Black-Right-Pointing-Pointer Supramolecule effects play a key role for improving the fluorescence property. Black-Right-Pointing-Pointer Notion presents an opportunity so far neglected area of CPE investigation. Black-Right-Pointing-Pointer Without previous treatment, urine species after CPE had no significant interference.

  3. Cloud point extraction-fluorimetric combined methodology for the determination of trace warfarin based on the sensitization effect of supramolecule

    International Nuclear Information System (INIS)

    Chang Zheng; Yan Hongtao

    2012-01-01

    Compared to the fluorescence spectra of warfarin in pure ethanol and in the presence of the nonionic surfactant Tergitol 15-S-7 after cloud point extraction (CPE), it can be seen that the fluorescence emission peak underwent an obvious red shift and the fluorescence intensity of warfarin was significantly increased in the presence of Tergitol 15-S-7. In order to confirm Tergitol 15-S-7-induced supramolecular effects, the investigations on the fluorescence quantum yields of warfarin in the micellar medium and pure ethanol were performed. The experimental results showed that the supramolecular interactions between Tergitol 15-S-7 and the warfarin excimers played a key role for improving the warfarin fluorescence properties. Based on these facts, a simple fluorometric method combined with CPE for the determination of trace warfarin was developed for the first time. Under optimized experimental conditions, the linear concentration range for warfarin was 3.0×1.0 −9 –1.0×10 −6 mol L −1 and the detection limit was 3.3×10 −10 mol L −1 . And, the proposed method was approved to be appropriate for monitoring warfarin in actual pharmaceutical formulations and biological fluid samples by recovery test, in comparison with other reported methods being satisfactory. - Highlights: ► A CPE fluorescence method for trace warfarin was developed for the first time. ► Supramolecule effects play a key role for improving the fluorescence property. ► Notion presents an opportunity so far neglected area of CPE investigation. ► Without previous treatment, urine species after CPE had no significant interference.

  4. Innovative learning for innovation

    NARCIS (Netherlands)

    Dr.Ir. Hay Geraedts

    2010-01-01

    Introduction Innovation is crucial for companies who have to react to constantly changing markets. Several national and European research institutes stress the importance of developing innovation for small and medium size enterprises (SMEs). This was a trigger to design a minor on strategic

  5. Generation and Diffusion of Innovations in a District Innovation System: The Case of Ink-Jet Printing

    Directory of Open Access Journals (Sweden)

    Yolanda Reig-Otero

    2014-06-01

    Full Text Available This paper provides an in-depth case study of the ink-jet printing (IJP technology that emerged from the ceramic industry in a Spanish region (Castellon in the first decade of 2000. We propose an analytical framework that combines the theoretical perspectives of Industrial Districts and Innovation Systems, and exploit a qualitative methodology that includes information from patent and scientific article databases and 21 in-depth interviews. Our results show that IJP is a major innovation that breaks with the tradition of machinery innovations in this industry in Spain. Micro-level evidences show the complex external and internal relationships in the sharing of knowledge and innovation process, being the role of internal ties, trust, secrecy and strong in-house R&D strategies determinants of the IJP innovation.

  6. Application of optimal design methodologies in retrofitting natural gas combined cycle power plants with CO_2 capture

    International Nuclear Information System (INIS)

    Pan, Ming; Aziz, Farah; Li, Baohong; Perry, Simon; Zhang, Nan; Bulatov, Igor; Smith, Robin

    2016-01-01

    Highlights: • A new approach is proposed for retrofitting NGCC power plants with CO2 capture. • HTI techniques are developed for improving heat recovery in NGCC power plants. • EGR techniques are developed to increase the process overall energy efficiency. • The proposed methods are efficient for practical application. - Abstract: Around 21% of the world’s power production is based on natural gas. Energy production is considered to be the significant sources of carbon dioxide (CO_2) emissions. This has a significant effect on the global warming. Improving power plant efficiency and adding a CO_2 capture unit into power plants, have been suggested to be a promising countermeasure against global warming. This paper presents a new insight to the application of energy efficient technologies in retrofitting natural gas combined cycle (NGCC) power plants with CO_2 capture. High fidelity models of a 420 MW NGCC power plant and a CO_2 capture plant with CO_2 compression train have been built and integrated for 90% capture level. These models have been then validated by comparisons with practical operating data and literature results. The novelty of the paper is to propose optimal retrofitting strategies to minimize the efficiency penalty caused by integrating carbon capture units into the power plant, including (1) implementing heat transfer intensification techniques to increase energy saving in the heat recovery steam generator (HRSG) of the power plant; (2) extracting suitable steam from the HRSG to supply the heat required by the capture process, thus on external heat is purchased; (3) employing exhaust gas recirculation (EGR) to increase the overall energy efficiency of the integrated process, which can benefit both power plant (e.g. increasing power plant efficiency) and capture process (e.g. reducing heat demands). Compared with the base case without using any integrating and retrofitting strategies, the optimal solution based on the proposed approaches

  7. Review: Heide von Felden (Ed. (2007. Methodendiskussion in der Biographieforschung [Methodological Issues in Biographical Research: Classical and Innovative Perspectives on Qualitative Analysis

    Directory of Open Access Journals (Sweden)

    Klaus Heuer

    2008-10-01

    Full Text Available This article assesses the extent to which the book under review lives up to the expectations raised by its title. The focus is thus on whether the results of interpreting the five featured case studies justify the methodological effort. The interaction between the text and the reader is left out and this is problematic when it comes to interpreting the memories of the Jewish emigrant who is at the centre of three out of the five essays. Furthermore, it is clear that on a formal level (relating to the shared analytical subject as well as in terms of content (relating to interconnectedness that the methodological discussion falls short of the requirements of the approach taken. URN: urn:nbn:de:0114-fqs0901193

  8. Future directions in psychological assessment: combining evidence-based medicine innovations with psychology's historical strengths to enhance utility.

    Science.gov (United States)

    Youngstrom, Eric A

    2013-01-01

    Assessment has been a historical strength of psychology, with sophisticated traditions of measurement, psychometrics, and theoretical underpinnings. However, training, reimbursement, and utilization of psychological assessment have been eroded in many settings. Evidence-based medicine (EBM) offers a different perspective on evaluation that complements traditional strengths of psychological assessment. EBM ties assessment directly to clinical decision making about the individual, uses simplified Bayesian methods explicitly to integrate assessment data, and solicits patient preferences as part of the decision-making process. Combining the EBM perspective with psychological assessment creates a hybrid approach that is more client centered, and it defines a set of applied research topics that are highly clinically relevant. This article offers a sequence of a dozen facets of the revised assessment process, along with examples of corollary research studies. An eclectic integration of EBM and evidence-based assessment generates a powerful hybrid that is likely to have broad applicability within clinical psychology and enhance the utility of psychological assessments.

  9. Logistics Innovation Process Revisited

    DEFF Research Database (Denmark)

    Gammelgaard, Britta; Su, Shong-Iee Ivan; Yang, Su-Lan

    2011-01-01

    Purpose – The purpose of this paper is to learn more about logistics innovation processes and their implications for the focal organization as well as the supply chain, especially suppliers. Design/methodology/approach – The empirical basis of the study is a longitudinal action research project...... that was triggered by the practical needs of new ways of handling material flows of a hospital. This approach made it possible to revisit theory on logistics innovation process. Findings – Apart from the tangible benefits reported to the case hospital, five findings can be extracted from this study: the logistics...... innovation process model may include not just customers but also suppliers; logistics innovation in buyer-supplier relations may serve as an alternative to outsourcing; logistics innovation processes are dynamic and may improve supplier partnerships; logistics innovations in the supply chain are as dependent...

  10. A combined methodology using electrical resistivity tomography, ordinary kriging and porosimetry for quantifying total C trapped in carbonate formations associated with natural analogues for CO2 leakage

    Science.gov (United States)

    Prado-Pérez, A. J.; Aracil, E.; Pérez del Villar, L.

    2014-06-01

    Currently, carbon deep geological storage is one of the most accepted methods for CO2 sequestration, being the long-term behaviour assessment of these artificial systems absolutely essential to guarantee the safety of the CO2 storage. In this sense, hydrogeochemical modelling is being used for evaluating any artificial CO2 deep geological storage as a potential CO2 sinkhole and to assess the leakage processes that are usually associated with these engineered systems. Carbonate precipitation, as travertines or speleothems, is a common feature in the CO2 leakage scenarios and, therefore, is of the utmost importance to quantify the total C content trapped as a stable mineral phase in these carbonate formations. A methodology combining three classical techniques such as: electrical resistivity tomography, geostatistical analysis and mercury porosimetry is described in this work, which was developed for calculating the total amount of C trapped as CaCO3 associated with the CO2 leakages in Alicún de las Torres natural analogue (Granada, Spain). The proposed methodology has allowed estimating the amount of C trapped as calcite, as more than 1.7 Mt. This last parameter, focussed on an artificial CO2 deep geological storage, is essential for hydrogeochemical modellers when evaluating whether CO2 storages constitute or not CO2 sinkholes. This finding is extremely important when assessing the long-term behaviour and safety of any artificial CO2 deep geological storage.

  11. Development of an innovative polygeneration process in hybrid solar-biomass system for combined power, cooling and desalination

    International Nuclear Information System (INIS)

    Sahoo, U.; Kumar, R.; Pant, P.C.; Chaudhary, R.

    2017-01-01

    Highlights: • Heat utilization from solar and biomass resources are considered for hybridization. • Modeling of polygeneration process in hybrid solar-biomass power plant is considered. • Thermodynamic evaluation are performed to identify the effect of various parameters. • Primary Energy Saving of polygeneration process is determined. - Abstract: In the polygeneration process simultaneous production of power, vapor absorption refrigeration (VAR) cooling and multi-effect humidification and dehumidification (MEHD) desalination system from different heat sources in hybrid solar-biomass (HSB) system with higher energy efficiency take place. It is one of the solutions to fulfill energy requirements from renewable sources and also helps in the reduction of carbon dioxide emissions. The VAR cooling system operates using the extracted heat taken from turbine and condenser heat of the VAR cooling system is used in desalination system for production of drinking water as per demand requirement. Though the production of electricity decreases due to extraction of heat from turbine for VAR cooling and desalination, the complete system meets the energy requirements & increases the primary energy savings (PES). The thermodynamic evaluation and optimization of HSB system in polygeneration process for combined power, cooling and desalination is investigated to identify the effects of various operating parameters. Primary energy savings (PES) of polygeneration process in HSB system is achieved to 50.5%. The energy output is increased to 78.12% from this system as compared to simple power plant.

  12. New Metamaterials with Combined Subnano - and Mesoscale Topology for High-efficiency Catalytic Combustion Chambers of Innovative Gas Turbine Engines

    Science.gov (United States)

    Knysh, Yu A.; Xanthopoulou, G. G.

    2018-01-01

    The object of the study is a catalytic combustion chamber that provides a highly efficient combustion process through the use of effects: heat recovery from combustion, microvortex heat transfer, catalytic reaction and acoustic resonance. High efficiency is provided by a complex of related technologies: technologies for combustion products heat transfer (recuperation) to initial mixture, catalytic processes technology, technology for calculating effective combustion processes based on microvortex matrices, technology for designing metamaterials structures and technology for obtaining the required topology product by laser fusion of metal powder compositions. The mesoscale level structure provides combustion process with the use of a microvortex effect with a high intensity of heat and mass transfer. High surface area (extremely high area-to-volume ratio) created due to nanoscale periodic structure and ensures catalytic reactions efficiency. Produced metamaterial is the first multiscale product of new concept which due to combination of different scale level periodic topologies provides qualitatively new set of product properties. This research is aimed at solving simultaneously two global problems of the present: ensure environmental safety of transport systems and power industry, as well as the economy and rational use of energy resources, providing humanity with energy now and in the foreseeable future.

  13. Combined Photoemission Spectroscopy and Electrochemical Study of a Mixture of (Oxy)carbides as Potential Innovative Supports and Electrocatalysts.

    Science.gov (United States)

    Calvillo, Laura; Valero-Vidal, Carlos; Agnoli, Stefano; Sezen, Hikmet; Rüdiger, Celine; Kunze-Liebhäuser, Julia; Granozzi, Gaetano

    2016-08-03

    Active and stable non-noble metal materials, able to substitute Pt as catalyst or to reduce the Pt amount, are vitally important for the extended commercialization of energy conversion technologies, such as fuel cells and electrolyzers. Here, we report a fundamental study of nonstoichiometric tungsten carbide (WxC) and its interaction with titanium oxycarbide (TiOxCy) under electrochemical working conditions. In particular, the electrochemical activity and stability of the WxC/TiOxCy system toward the ethanol electrooxidation reaction (EOR) and hydrogen evolution reaction (HER) are investigated. The chemical changes caused by the applied potential are established by combining photoemission spectroscopy and electrochemistry. WxC is not active toward the ethanol electrooxidation reaction at room temperature but it is highly stable under these conditions thanks to the formation of a passive thin film on the surface, consisting mainly of WO2 and W2O5, which prevents the full oxidation of WxC. In addition, WxC is able to adsorb ethanol, forming ethoxy groups on the surface, which constitutes the first step for the ethanol oxidation. The interaction between WxC and TiOxCy plays an important role in the electrochemical stability of WxC since specific orientations of the substrate are able to stabilize WxC and prevent its corrosion. The beneficial interaction with the substrate and the specific surface chemistry makes tungsten carbide a good electrocatalyst support or cocatalyst for direct ethanol fuel cells. However, WxC is active toward the HER and chemically stable under hydrogen reduction conditions, since no changes in the chemical composition or dissolution of the film are observed. This makes tungsten carbide a good candidate as electrocatalyst support or cocatalyst for the electrochemical production of hydrogen.

  14. Comparison of an Innovative Rehabilitation, Combining Reduced Conventional Rehabilitation with Balneotherapy, and a Conventional Rehabilitation after Anterior Cruciate Ligament Reconstruction in Athletes

    Directory of Open Access Journals (Sweden)

    Laetitia Peultier-Celli

    2017-11-01

    Full Text Available BackgroundInstability of the knee, related to anterior cruciate ligament injury, is treated by surgical reconstruction. During recovery, a loss of proprioceptive input can have a significant impact. Few studies have evaluated the benefits of rehabilitation of the knee in aquatic environment on functional outcomes.ObjectiveThis study aimed to compare an innovative rehabilitation protocol combining reduced conventional rehabilitation with aquatic rehabilitation, with a conventional rehabilitation, according to the National French Health Authority, in terms of kinetics, development of proprioceptive skills, and functional improvement of the knee.Methods67 patients, who were amateur or professional athletes, were randomized into two groups: 35 patients followed the conventional rehabilitation protocol (Gr1 and 32 patients followed the innovative rehabilitation protocol (Gr2. Patients were evaluated before surgery, and at 2 weeks, 1, 2, and 6 months after surgery using posturography, and evaluation of muscular strength, walking performance and proprioception. This study is multicenter, prospective, randomized, and controlled with a group of patients following conventional rehabilitation (level of evidence I.ResultsFor the same quality of postural control, Gr2 relied more on somesthesia than Gr1 at 6 months. The affected side had an impact on postural control and in particular on the preoperative lateralization, at 2 weeks and at 1 month. Lateralization depended on the affected knee, with less important lateralization in Gr2 preoperatively and at 1 month. The quadriceps muscular strength was higher in Gr2 than in Gr1 at 2 and 6 months and muscle strength of the external hamstring was greater in Gr2 than in Gr1 at 6 months. The isokinetic test showed a greater quadriceps muscular strength in Gr2. Gr2 showed a greater walking distance than Gr1 at one month. Gr2 showed an improvement in the proprioceptive capacities of the operated limb

  15. Guidance for the application of an assessment methodology for innovative nuclear energy systems. INPRO manual - Safety of nuclear fuel cycle facilities. Vol. 9 of the final report of phase 1 of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO)

    International Nuclear Information System (INIS)

    2008-11-01

    The International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) was initiated in the year 2000, based on a resolution of the IAEA General Conference (GC(44)/RES/21). The main objectives of INPRO are (1) to help to ensure that nuclear energy is available to contribute in fulfilling energy needs in the 21st century in a sustainable manner, (2) to bring together both technology holders and technology users to consider jointly the international and national actions required to achieve desired innovations in nuclear reactors and fuel cycles; and (3) to create a forum to involve all relevant stakeholders that will have an impact on, draw from, and complement the activities of existing institutions, as well as ongoing initiatives at the national and international level. The INPRO manual is comprised of an overview volume (No. 1), and eight additional volumes covering the areas of economics (Volume 2), infrastructure (Volume 3), waste management (Volume 4), proliferation resistance (Volume 5), physical protection (Volume 6), environment (Volume 7), safety of nuclear reactors (Volume 8), and safety of nuclear fuel cycle facilities (laid out in this report) (Volume 9).This report elaborates on the guidance given in the INPRO report 'Methodology for the assessment of innovative nuclear reactors and fuel cycles', IAEA-TECDOC-1434, and the previous INPRO report 'Guidance for the evaluation for innovative nuclear reactors and fuel cycles', IAEA-TECDOC-1362 (2003), in the area of safety of nuclear reactors. The present version of this manual deals with safety issues related to design and operation of mining, milling, refining, conversion, enrichment, fuel fabrication, fuel storage and fuel reprocessing facilities. The INPRO Manual starts with an introduction in Chapter 1. Chapter 2 sets out the necessary input for an INPRO assessment of the safety of an innovative nuclear fuel cycle facility. This includes information on the design for the plant and the safety

  16. Formalizing the ISDF Software Development Methodology

    OpenAIRE

    Mihai Liviu DESPA

    2015-01-01

    The paper is aimed at depicting the ISDF software development methodology by emphasizing quality management and software development lifecycle. The ISDF methodology was built especially for innovative software development projects. The ISDF methodology was developed empirically by trial and error in the process of implementing multiple innovative projects. The research process began by analysing key concepts like innovation and software development and by settling the important dilemma of wha...

  17. Efficient Preparation of Streptochlorin from Marine Streptomyces sp. SYYLWHS-1-4 by Combination of Response Surface Methodology and High-Speed Counter-Current Chromatography.

    Science.gov (United States)

    Li, Lin; He, Shan; Ding, Lijian; Yuan, Ye; Zhu, Peng; Epstein, Slava; Fan, Jianzhong; Wu, Xiaokai; Yan, Xiaojun

    2016-05-27

    Since first isolated from the lipophilic extract of Streptomyces sp. SF2583, streptochlorin, has attracted a lot of attention because of its various pharmacological properties, such as antibiotic, antiallergic, antitumor, and anti-inflammatory activities. For the efficient preparation of streptochlorin from a producing strain Streptomyces sp. SYYLWHS-1-4, we developed a combinative method by using response surface methodology (RSM) and high-speed counter-current chromatography (HSCCC). In the fermentation process, we used RSM to optimize the condition for the efficient accumulation of streptochlorin, and the optimal parameters were: yeast extract 1.889 g/L, soluble starch 8.636 g/L, K₂HPO₄ 0.359 g/L, CaCl₂ 2.5 g/L, MgSO₄ 0.625 g/L, marine salt 25 g/L, medium volume 50%, initial pH value 7.0, temperature 27.5 °C, which enhanced streptochlorin yield by 17.7-fold. During the purification process, the preparative HSCCC separation was performed using a petroleum ether-ethyl acetate-methanol-water (9:0.8:5:5, v/v/v/v) biphasic solvent system, where 300 mg of crude sample yielded 16.5 mg streptochlorin with over 95% purity as determined by UPLC. Consequently, the combination method provided a feasible strategy for highly effective preparation of streptochlorin, which ensured the supply of large amounts of streptochlorin for in vivo pharmacological assessments or other requirements.

  18. Nuclear data covariances and sensitivity analysis, validation of a methodology based on the perturbation theory; application to an innovative concept: the molten thorium salt fueled reactor

    International Nuclear Information System (INIS)

    Bidaud, A.

    2005-10-01

    Neutron transport simulation of nuclear reactors is based on the knowledge of the neutron-nucleus interaction (cross-sections, fission neutron yields and spectra...) for the dozens of nuclei present in the core over a very large energy range (fractions of eV to several MeV). To obtain the goal of the sustainable development of nuclear power, future reactors must have new and more strict constraints to their design: optimization of ore materials will necessitate breeding (generation of fissile material from fertile material), and waste management will require transmutation. Innovative reactors that could achieve such objectives - generation IV or ADS (accelerator driven system) - are loaded with new fuels (thorium, heavy actinides) and function with neutron spectra for which nuclear data do not benefit from 50 years of industrial experience, and thus present particular challenges. After validation on an experimental reactor using an international benchmark, we take classical reactor physics tools along with available nuclear data uncertainties to calculate the sensitivities and uncertainties of the criticality and temperature coefficient of a thorium molten salt reactor. In addition, a study based on the important reaction rates for the calculation of cycle's equilibrium allows us to estimate the efficiency of different reprocessing strategies and the contribution of these reaction rates on the uncertainty of the breeding and then on the uncertainty of the size of the reprocessing plant. Finally, we use this work to propose an improvement of the high priority experimental request list. (author)

  19. Analysis of Russian transition scenarios to innovative nuclear energy system based on thermal and fast reactors with closed nuclear fuel cycle using INPRO methodology

    International Nuclear Information System (INIS)

    Kagramanyan, V.S.; Poplavskaya, E.V.; Korobeynikov, V.V.; Kalashnikov, A.G.; Moseev, A.L.; Korobitsyn, V.E.; Andreeva-Andrievskaya, L.N.

    2011-01-01

    This paper presents the results of the analysis of modeling of Russian nuclear energy (NE) scenarios on the basis of thermal and fast reactors with closed nuclear fuel cycle (NFC). Modeling has been carried out with use of CYCLE code (SSC RF IPPE's tool) designed for analysis of Nuclear Energy System (NES) with closed NFC taking into account plutonium and minor actinides (MA) isotopic composition change during multi-recycling of fuel in fast reactors. When considering fast reactor introduction scenarios, one of important questions is to define optimal time for their introduction and related NFC's facilities. Analysis of the results obtained has been fulfilled using the key INPRO indicators for sustainable energy development. It was shown that a delay in fast reactor introduction led to serious ecological, social and finally economic risks for providing energy security and sustainable development of Russia in long-term prospects and loss of knowledge and experience in mastering innovative technologies of fast reactors and related nuclear fuel cycle. (author)

  20. Implementation of PEF Treatment at Real-Scale Tomatoes Processing Considering LCA Methodology as an Innovation Strategy in the Agri-Food Sector

    Directory of Open Access Journals (Sweden)

    Álvaro J. Arnal

    2018-03-01

    Full Text Available In Europe, science and innovation are boosting the agri-food sector and, in parallel, are helping to decrease greenhouse gas emissions (GHG and European dependency on non-renewable resources. Currently, it is well-known that this sector contributes to the consumption of energy and material resources, causing significant environmental impacts that require a complex and comprehensive environmental evaluation in order to manage them effectively. This becomes even more complicated when new technologies are reaching the level of technological maturity needed to be installed in the production lines. To address this scientific challenge, the life cycle assessment (LCA has been used in this paper to evaluate the potential of pulsed electric fields (PEF technology at an industrial scale to facilitate the steam peeling of tomato fruits. Considering the thermo-physical peeling stage, the LCA has shown that PEF technology is environmentally friendly, because when PEF technology is applied, all the considered environmental indicators improve between 17% and 20%.

  1. Structural Conditions for Collaboration and Learning in Innovation Networks: Using an Innovation System Performance Lens to Analyse Agricultural Knowledge Systems

    NARCIS (Netherlands)

    Hermans, F.; Klerkx, L.W.A.; Roep, D.

    2015-01-01

    Purpose: We investigate how the structural conditions of eight different European agricultural innovation systems can facilitate or hinder collaboration and social learning in multidisciplinary innovation networks. Methodology: We have adapted the Innovation System Failure Matrix to investigate the

  2. Innovation af innovation

    DEFF Research Database (Denmark)

    Harste, Gorm

    2009-01-01

    , at innovation af innovationen forsøges gennemført på en måde, hvor tiden kræves at forholde sig til sin egen tidslighed i form af fremtid, nutid, fortid og ikke mindst i form af samtidighed. I tiden skal vi iagttage, hvordan vi iagttager tiden. Vi dobbelt-koder tiden på samme måde, som forskning forsker i...... organisationssystemerne. De to typer systemer kan noget helt bestemt med fænomenet tid. De kan synkronisere. Analyseres organisationssystemer ser vi, imidlertid at innovation kræver ro. Stærkt innovative systemer er militærsystemet og kunstsystemet, der også inddrages, og hvor vi ser paradokset mellem innovation og...... involution. Tid er med et medium og ikke et lufttomt rum. Tid er end ikke en gasart, men udgør et solidt fluidum, som samfundet bader i og flyder i, konstant i bevægelse. Reformer forudsætter former, og innovation forudsætter involution. Kun sådan muliggøres evolution....

  3. Orchestrating innovation

    NARCIS (Netherlands)

    Berkers, F.T.H.M.; Klein Woolthuis, R.J.A.; Boer, J. de

    2015-01-01

    Orchestrating Innovation increases the probability of success, minimizing the probability of failure of technological innovations by creating sustained societal and economic value. Orchestrating innovation propagates to take into account and actively involve all relevant stakeholders of the (future)

  4. Innovative spectrophotometric methods for simultaneous estimation of the novel two-drug combination: Sacubitril/Valsartan through two manipulation approaches and a comparative statistical study

    Science.gov (United States)

    Eissa, Maya S.; Abou Al Alamein, Amal M.

    2018-03-01

    Different innovative spectrophotometric methods were introduced for the first time for simultaneous quantification of sacubitril/valsartan in their binary mixture and in their combined dosage form without prior separation through two manipulation approaches. These approaches were developed and based either on two wavelength selection in zero-order absorption spectra namely; dual wavelength method (DWL) at 226 nm and 275 nm for valsartan, induced dual wavelength method (IDW) at 226 nm and 254 nm for sacubitril and advanced absorbance subtraction (AAS) based on their iso-absorptive point at 246 nm (λiso) and 261 nm (sacubitril shows equal absorbance values at the two selected wavelengths) or on ratio spectra using their normalized spectra namely; ratio difference spectrophotometric method (RD) at 225 nm and 264 nm for both of them in their ratio spectra, first derivative of ratio spectra (DR1) at 232 nm for valsartan and 239 nm for sacubitril and mean centering of ratio spectra (MCR) at 260 nm for both of them. Both sacubitril and valsartan showed linearity upon application of these methods in the range of 2.5-25.0 μg/mL. The developed spectrophotmetric methods were successfully applied to the analysis of their combined tablet dosage form ENTRESTO™. The adopted spectrophotometric methods were also validated according to ICH guidelines. The results obtained from the proposed methods were statistically compared to a reported HPLC method using Student t-test, F-test and a comparative study was also developed with one-way ANOVA, showing no statistical difference in accordance to precision and accuracy.

  5. Combination of ozone feed and wet electrostatic precipitator. Experimental study of an innovative system to filter gaseous iodine and iodine containing particles

    International Nuclear Information System (INIS)

    Gouëllo, Mélany; Hokkinen, Jouni; Kärkelä, Teemu; Auvinen, Ari

    2017-01-01

    Efficient mitigation systems capable of reducing as much as possible the radioactive discharge to the environment in a severe Nuclear Power Plant (NPP) accident are a necessity. Nuclear Power Plants are equipped with filtration systems which have been characterized for aerosol retention in a short term, but to a far lesser extent for the retention of volatile iodine or for the long-term behaviour of the system. After the Fukushima accident, one of the main concerns of the nuclear industry has been to verify the ability of filtration systems to mitigate the possible source term to the environment. Radiotoxic iodine has a significant contribution to a possible source term in a severe NPP accident. An innovative system has been developed at VTT Technical Research Centre of Finland Ltd. to filter gaseous iodine and iodine containing particles (e.g. I x O y ). The system consists of a combination of an ozone feed and a modern wet electrostatic precipitator (WESP). The electrostatic precipitation (ESP) technique is widely used in the industry to filter out impurities (i.e. particles) in gases. The advantage of a WESP is that the impurities are removed from the system with a solution. They can thus directly be transported to a water container, such as the sump in a nuclear power plant. The addition of ozone feed at the inlet of the WESP allows the oxidation of gaseous iodine into particles. The efficiency of the system for the filtration of gaseous molecular iodine and methyl iodine has been tested and the subsequent observations are further discussed in this paper. The results showed that the combination of WESP together with ozone feed results in a good filtering efficiency against molecular iodine under air atmosphere and air/steam atmosphere. (author)

  6. Efficient Preparation of Streptochlorin from Marine Streptomyces sp. SYYLWHS-1-4 by Combination of Response Surface Methodology and High-Speed Counter-Current Chromatography

    Directory of Open Access Journals (Sweden)

    Lin Li

    2016-05-01

    Full Text Available Since first isolated from the lipophilic extract of Streptomyces sp. SF2583, streptochlorin, has attracted a lot of attention because of its various pharmacological properties, such as antibiotic, antiallergic, antitumor, and anti-inflammatory activities. For the efficient preparation of streptochlorin from a producing strain Streptomyces sp. SYYLWHS-1-4, we developed a combinative method by using response surface methodology (RSM and high-speed counter-current chromatography (HSCCC. In the fermentation process, we used RSM to optimize the condition for the efficient accumulation of streptochlorin, and the optimal parameters were: yeast extract 1.889 g/L, soluble starch 8.636 g/L, K2HPO4 0.359 g/L, CaCl2 2.5 g/L, MgSO4 0.625 g/L, marine salt 25 g/L, medium volume 50%, initial pH value 7.0, temperature 27.5 °C, which enhanced streptochlorin yield by 17.7-fold. During the purification process, the preparative HSCCC separation was performed using a petroleum ether–ethyl acetate–methanol–water (9:0.8:5:5, v/v/v/v biphasic solvent system, where 300 mg of crude sample yielded 16.5 mg streptochlorin with over 95% purity as determined by UPLC. Consequently, the combination method provided a feasible strategy for highly effective preparation of streptochlorin, which ensured the supply of large amounts of streptochlorin for in vivo pharmacological assessments or other requirements.

  7. Methodology for modeling the disinfection efficiency of fresh-cut leafy vegetables wash water applied on peracetic acid combined with lactic acid.

    Science.gov (United States)

    Van Haute, S; López-Gálvez, F; Gómez-López, V M; Eriksson, Markus; Devlieghere, F; Allende, Ana; Sampers, I

    2015-09-02

    A methodology to i) assess the feasibility of water disinfection in fresh-cut leafy greens wash water and ii) to compare the disinfectant efficiency of water disinfectants was defined and applied for a combination of peracetic acid (PAA) and lactic acid (LA) and comparison with free chlorine was made. Standardized process water, a watery suspension of iceberg lettuce, was used for the experiments. First, the combination of PAA+LA was evaluated for water recycling. In this case disinfectant was added to standardized process water inoculated with Escherichia coli (E. coli) O157 (6logCFU/mL). Regression models were constructed based on the batch inactivation data and validated in industrial process water obtained from fresh-cut leafy green processing plants. The UV254(F) was the best indicator for PAA decay and as such for the E. coli O157 inactivation with PAA+LA. The disinfection efficiency of PAA+LA increased with decreasing pH. Furthermore, PAA+LA efficacy was assessed as a process water disinfectant to be used within the washing tank, using a dynamic washing process with continuous influx of E. coli O157 and organic matter in the washing tank. The process water contamination in the dynamic process was adequately estimated by the developed model that assumed that knowledge of the disinfectant residual was sufficient to estimate the microbial contamination, regardless the physicochemical load. Based on the obtained results, PAA+LA seems to be better suited than chlorine for disinfecting process wash water with a high organic load but a higher disinfectant residual is necessary due to the slower E. coli O157 inactivation kinetics when compared to chlorine. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. Institutional Capacity of Innovation Activity Development in theRegion

    Directory of Open Access Journals (Sweden)

    Aleksei Aleksandrovich Rumyantsev

    2016-09-01

    Full Text Available The article presents the results of the study under the theme of development of institutions of innovation sphere, transfer of scientific results to the real sector of the economy. The purpose of the study is to reveal institutional capacities of strengthening the implementation of research findings, drawing on the functional properties of institutions with regard to innovation activities. The methodology is to apply well-known methodological principles to the solution of emerging challenges (software-based method for fundamental scientific result implementation, sectoral research organizations in the new management environment and statistical records of process innovations by analogy with product innovations. The article puts forward and justifies the proposal for strategic innovation as the institution of communicating the results of fundamental research to social practice by integrating into a single process the results of oriented fundamental research, applied research, engineering development, development and other works, which are realized in the form of a material object or service of a high technology level. The distinguishing feature of strategic innovation is a future-oriented outlook and the solution of long-term objectives. Russian scientific achievements can become the basis for strategic innovation development. The article gives examples of possible research field where strategic innovation can be developed and demonstrates an innovative implementation mechanism in the format of specialized research-and-production program which combines government and business participation. The paper gives arguments and development ways of the institution of sectoral research organizations as providers of state technological policy in sectors and regions; coordination of import substitution; centers of communication establishment with engineering companies; analytical and predictive research. The study justifies the expediency of developing an

  9. Firm value creation and viability between product and process innovation

    Directory of Open Access Journals (Sweden)

    Maria Fedele

    2014-01-01

    Full Text Available The role and characteristics of the innovation process have undergone changes throughout the history of industrial capitalism. In the contest of an emerging systemic complexity, technological innovation is able to generate a positive impact on the economic performances of companies by improving their internal efficiency, which allows to increase the market competitiveness. Innovation is, in fact, the leverage to gain competitive advantages that are the source of value creation and sustainable growth, to preserve and celebrate as one of the key components of the intangible assets of companies. Starting from Schumpeter's process of creative destruction, which considers innovation as “the engine of economic development” and “a continuous process of change and accumulation of knowledge”. The paper analyzes the variables at the center of innovation studies, the innovative approach and the impact of technological positioning as early-mover or follower in the market. Peculiarities will be described related to the definition of the project portfolio mix, the process of designing and developing of a new product, as well as the relationship between innovation and competitive advantage. Further attention will be placed on the targets of innovation and on the factors, objective and context, which hinder the willingness by the entrepreneur to „break‟ the stationary balance by introducing new combinations production factors as an essential condition for the maintenance of competitive advantage and the creation of value. The research approach is based on a qualitative methodology. The data retrieval was carried out through secondary sources.

  10. Investigation by response surface methodology of the combined effect of pH and composition of water-methanol mixtures on the stability of curcuminoids.

    Science.gov (United States)

    D'Archivio, Angelo Antonio; Maggi, Maria Anna

    2017-03-15

    Response surface methodology, coupled to a full factorial three-level experimental design, was applied to investigate the combined influence of pH (between 7.0 and 8.6) and composition of methanol-water mixtures (between 30 and 70% v/v of methanol content) on the stability of curcumin and its analogues demethoxycurcumin and bisdemethoxycurcumin. The response plots revealed that addition of methanol noticeably improved the stability of curcuminoids, this effect being both pH- and structure-dependent. In the central point of the experimental domain, half-life times of curcumin, demethoxycurcumin and bisdemethoxycurcumin were 3.8±0.2, 27±2 and 251±17h, respectively. Stability of curcuminoids increased at lower pH and higher methanol content and decreased in the opposite vertex of the experimental domain. These results can be interpreted by assuming that addition of methanol to water produces a different variation of pH of the medium and apparent pKa values of the ionisable groups of curcuminoids. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. Combined treatment of Thymus vulgaris L., Rosmarinus officinalis L. and Myrtus communis L. essential oils against Salmonella typhimurium: Optimization of antibacterial activity by mixture design methodology.

    Science.gov (United States)

    Fadil, Mouhcine; Fikri-Benbrahim, Kawtar; Rachiq, Saad; Ihssane, Bouchaib; Lebrazi, Sara; Chraibi, Marwa; Haloui, Taoufik; Farah, Abdellah

    2018-05-01

    To increase the sensibility of Salmonella typhimurium strain, a mixture of Thymus vulgaris L. (T. vulgaris L.), Rosmarinus officinalis L. (R. officinalis L.) and Myrtus communis L. (M. communis L.) essential oils (EOs) was used in combined treatment by experimental design methodology (mixture design). The chemical composition of EOs was firstly identified by GC and GC/MS and their antibacterial activity was evaluated. The results of this first step have shown that thymol and borneol were the major compounds in T. vulgaris and M. communis L. EOs, respectively, while 1,8-cineole and α-pinene were found as major compounds in R. officinalis L. The same results have shown a strong antibacterial activity of T. vulgaris L. EO followed by an important power of M. communis L. EO against a moderate activity of R. officinalis L. EO. Besides, 1/20 (v/v) was the concentration giving a strain response classified as sensitive. From this concentration, the mixture design was performed and analyzed. The optimization of mixtures antibacterial activities has highlighted the synergistic effect between T. vulgaris L. and M. communis L. essential oils. A formulation comprising 55% of T. vulgaris L. and 45% of M. communis L. essential oils, respectively, can be considered for the increase of Salmonella typhimurium sensibility. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Service Innovation and Management Innovation: The Role of Service Tangibility

    NARCIS (Netherlands)

    Alexiev, A.S.; Janssen, Matthijs; den Hertog, P.

    2015-01-01

    Although we have some knowledge about how different types of innovation can be combined together to improve firm performance, there is little research about the relationships that innovation types may have among them. In this paper, we examine how service innovation is related to organizational

  13. Market Orientation, Innovativeness, Product Innovation, and Performance in Small Firms

    NARCIS (Netherlands)

    Verhees, F.J.H.M.; Meulenberg, M.T.G.

    2004-01-01

    Most research on market orientation, innovation and performance is related to big enterprises and small and medium-sized enterprises (SMEs). In this study a model is developed to investigate the combined effect of market orientation and innovativeness on product innovation and company performance,

  14. Supplier selection in manufacturing innovation chain-oriented public procurement based on improved PSO method

    Directory of Open Access Journals (Sweden)

    Xin Xu

    2014-01-01

    Full Text Available Purpose: At the dynamic innovation market, it is very difficult for an enterprise to accomplish innovation individually; technology innovation is shifting towards collaborative R&D chain mode. Thus, supplier selection based on individually innovation efficiency of enterprise is inapplicable to construct collaborative R&D innovation chain. This study is seeking to address how to select R&D innovation chain supplier in manufacturing industry. Design/methodology/approach: Firstly, Delphi method and AHP method are applied to establish an index system evaluating the suppliers of innovation chain, and then each index is weighted by experts with AHP method. Thirdly, optimized PSO algorithm is put forwarded based on the optimal efficiency of innovation chain to discriminate ideal suppliers meeting realistic conditions. Fourthly, innovation chain construction at generator manufacturing industry was taken as empirical case study to testify the improved PSO model. Findings: The innovation chain is comprised up by several enterprises, innovation performance of a single enterprise is not always positively correlated to that of one innovation chain, and the proposed model is capable to find out the best combination to construct an innovation chain. Research limitations/implications: The relations between these constructs with other variables of interest to the academicals fields were analyzed by a precise and credible data with a clear and concise description of the supply chain integration measurement scales. Practical implications: providing scales that are valid as a diagnostic tool for best practices, as well as providing a benchmark with which to compare the score for each individual plant against a chain of industrial innovation from machinery. Originality/value: Innovation chain integration is an important factor in explaining the innovation performance of companies. The vast range of results obtained is due to the fact that there is no exactness to

  15. How to make innovation practical

    NARCIS (Netherlands)

    Janssen, F.J.J.M.; Westbroek, H.B.; Doyle, W.; Van Driel, J.H.

    2013-01-01

    Many attempts to reform teaching fail to be enacted in most classrooms. The purpose of this paper is to present a bridging methodology for connecting pedagogical innovations to the practical demands of teaching.

  16. Public sector innovation

    DEFF Research Database (Denmark)

    Wegener, Charlotte

    2012-01-01

    This paper explores the value dimension of public innovation in the light of practitioners’ values and asks why there seems to be a clash between innovation imperatives and workplace practices in the public sector. The paper contributes to the research on public innovation from a practice...... perspective by providing evidence from an ethnographic field study on innovation in social and health care studies in Denmark. These studies are part of the vocational education and training (VET) system, which combines coursework at a college and internship in the elder care sector. The study is thus cross...... initiate innovations grounded in their values. The main point put forward is that the value dimension of public innovation must be understood not only in terms of value creation (economic or non-economic), which frontline practitioners are required to contribute to, but also as value-based practices...

  17. Measuring Manufacturing Innovativeness

    DEFF Research Database (Denmark)

    Blichfeldt, Henrik; Knudsen, Mette Præst

    2017-01-01

    Globalization and customization increases the pressure on manufacturing companies, and the ability to provide innovativeness is a potential source of competitive advantage. This paper positions the manufacturing entity in the innovation process, and investigates the relation between innovation vers...... technology and organizational concepts. Based on Danish survey data from the European Manufacturing Survey (EMS-2015) this paper finds that there is a relation between innovative companies, and their level of technology and use of organizational concepts. Technology and organizational concepts act...... as manufacturing levers to support the manufacturing and production system to provide innovativeness. The managerial implication lies in building manufacturing capabilities to support the innovative process, by standardization, optimization and creating stability in combination with automation and advanced...

  18. The role of herbaceous crops in soil carbon and nitrogen cycles in relation to soil management . methodological approaches and innovative technologies

    International Nuclear Information System (INIS)

    Mohamed, M.A.A.

    2010-01-01

    Soil organic matter is an important pool within the total organic carbon of the planet,being equal to twice that if the atmosphere and three times the biotic one.Organic carbon sequestration in agricultural soils is therefore considered one of the most effective tools to counterbalance the emission of CO 2 from fossil fuels combustion. The role of below ground plant parts in carbon sequestration is much more difficult that of above.ground parts because of the open issues about the determination of root biometrics and root exhudates. Recent literature indicates that root biomass is probably much larger than classically believed and that root surface where exhudation occurs is also underestimated, and so is its role in the rhizosphere.The general objective of this thesis is the evaluation of carbon sequestration in sorghum as a function of soil management. A specific objective is to approach methodological problems relevant to the accurate quantification of the contribution of below ground plant structures to athmosferic carbon sequestration. This objective will be approached through a thorough review of the literature and an experimental setup with different soil management systems in relation to organic matter. In the review special attention is given to the applied tracer methods. The contribution of plant derived organic substances to the SOM turnover obtained with 13 C natural abundance is also reviewed. A related objective is the monitoring of nitrogen dynamics discriminating the contribution of organic matter applied to the soil. In addition to organic C, soil may also contain inorganic C in the form of carbonates. This is of particular relevance to dry lands because calcification and formation of secondary carbonate is an important process in arid and semi-arid regions. Consequently the largest accumulations of carbonate occur in the soils of arid and semi-arid areas. Dynamics of the inorganic carbon pool are poorly understood although it is normally quite

  19. Orchestrating innovation

    OpenAIRE

    Berkers, F.T.H.M.; Klein Woolthuis, R.J.A.; Boer, J. de

    2015-01-01

    Orchestrating Innovation increases the probability of success, minimizing the probability of failure of technological innovations by creating sustained societal and economic value. Orchestrating innovation propagates to take into account and actively involve all relevant stakeholders of the (future) ecosystem in which the innovation will, can or has to be adopted.

  20. Mindful innovation

    DEFF Research Database (Denmark)

    Olsen, Poul Bitsch

    2008-01-01

    Mindful innovation is an approach to innovation that pays attention to people's experience in an organization rather than to formal organization or social role.......Mindful innovation is an approach to innovation that pays attention to people's experience in an organization rather than to formal organization or social role....

  1. A combined QC methodology in Ebro Delta HF radar system: real time web monitoring of diagnostic parameters and offline validation of current data

    Science.gov (United States)

    Lorente, Pablo; Piedracoba, Silvia; Soto-Navarro, Javier; Ruiz, Maria Isabel; Alvarez Fanjul, Enrique

    2015-04-01

    Over recent years, special attention has been focused on the development of protocols for near real-time quality control (QC) of HF radar derived current measurements. However, no agreement has been worldwide achieved to date to establish a standardized QC methodology, although a number of valuable international initiatives have been launched. In this context, Puertos del Estado (PdE) aims to implement a fully operational HF radar network with four different Codar SeaSonde HF radar systems by means of: - The development of a best-practices robust protocol for data processing and QC procedures to routinely monitor sites performance under a wide variety of ocean conditions. - The execution of validation works with in-situ observations to assess the accuracy of HF radar-derived current measurements. The main goal of the present work is to show this combined methodology for the specific case of Ebro HF radar (although easily expandable to the rest of PdE radar systems), deployed to manage Ebro River deltaic area and promote the conservation of an important aquatic ecosystem exposed to a severe erosion and reshape. To this aim, a web interface has been developed to efficiently monitor in real time the evolution of several diagnostic parameters provided by the manufacturer (CODAR) and used as indicators of HF radar system health. This web, updated automatically every hour, examines sites performance on different time basis in terms of: - Hardware parameters: power and temperature. - Radial parameters, among others: Signal-to-Noise Ratio (SNR), number of radial vectors provided by time step, maximum radial range and bearing. - Total uncertainty metrics provided by CODAR: zonal and meridional standard deviations and covariance between both components. - Additionally, a widget embedded in the web interface executes queries against PdE database, providing the chance to compare current time series observed by Tarragona buoy (located within Ebro HF radar spatial domain) and

  2. Eco-Innovation Manual

    DEFF Research Database (Denmark)

    O'Hare, Jamie Alexander; McAloone, Tim C.; Pigosso, Daniela Cristina Antelmi

    Aim of this manual is to introduce a methodology for the implementation of eco‐innovation within small and medium sized companies in developing and emerging economies. The intended audience of this manual is organizations that provide professional services to guide and support manufacturing compa...... companies to improve their sustainability performance....

  3. COST EFFECTIVE VOC EMISSION CONTROL STARTEGIES FOR MILITARY, AEROSPACE,AND INDUSTRIAL PAINT SPRAY BOOTH OPERATIONS: COMBINING IMPROVED VENTILATION SYSTEMS WITH INNOVATIVE, LOW COST EMISSION CONTROL TECHNOLOGIES

    Science.gov (United States)

    The paper describes a full-scale demonstration program in which several paint booths were modified for recirculation ventilation; the booth exhaust streams are vented to an innovative volatile organic compound (VOC) emission control system having extremely low operating costs. ...

  4. A computational methodology for a micro launcher engine test bench using a combined linear static and dynamic in frequency response analysis

    Directory of Open Access Journals (Sweden)

    Ion DIMA

    2017-03-01

    Full Text Available This article aims to provide a quick methodology to determine the critical values of the forces, displacements and stress function of frequency, under a combined linear static (101 Solution - Linear Static and dynamic load in frequency response (108 Solution - Frequency Response, Direct Method, applied to a micro launcher engine test bench, using NASTRAN 400 Solution - Implicit Nonlinear. NASTRAN/PATRAN software is used. Practically in PATRAN the preprocessor has to define a linear or nonlinear static load at step 1 and a dynamic in frequency response load (time dependent at step 2. In Analyze the following options are chosen: for Solution Type Implicit Nonlinear Solution (SOL 400 is selected, for Subcases Static Load and Transient Dynamic is chosen and for Subcase Select the two cases static and dynamic will be selected. NASTRAN solver will overlap results from static analysis with the dynamic analysis. The running time will be reduced three times if using Krylov solver. NASTRAN SYSTEM (387 = -1 instruction is used in order to activate Krylov option. Also, in Analysis the OP2 Output Format shall be selected, meaning that in bdf NASTRAN input file the PARAM POST 1 instruction shall be written. The structural damping can be defined in two different ways: either at the material card or using the PARAM, G, 0.05 instruction (in this example a damping coefficient by 5% was used. The SDAMPING instruction in pair with TABDMP1 work only for dynamic in frequency response, modal method, or in direct method with viscoelastic material, not for dynamic in frequency response, direct method (DFREQ, with linear elastic material. The Direct method – DFREQ used in this example is more accurate. A set in translation of boundary conditions was used and defined at the base of the test bench.

  5. A methodological framework for detecting ulcers' risk in diabetic foot subjects by combining gait analysis, a new musculoskeletal foot model and a foot finite element model.

    Science.gov (United States)

    Scarton, Alessandra; Guiotto, Annamaria; Malaquias, Tiago; Spolaor, Fabiola; Sinigaglia, Giacomo; Cobelli, Claudio; Jonkers, Ilse; Sawacha, Zimi

    2018-02-01

    Diabetic foot is one of the most debilitating complications of diabetes and may lead to plantar ulcers. In the last decade, gait analysis, musculoskeletal modelling (MSM) and finite element modelling (FEM) have shown their ability to contribute to diabetic foot prevention and suggested that the origin of the plantar ulcers is in deeper tissue layers rather than on the plantar surface. Hence the aim of the current work is to develop a methodology that improves FEM-derived foot internal stresses prediction, for diabetic foot prevention applications. A 3D foot FEM was combined with MSM derived force to predict the sites of excessive internal stresses on the foot. In vivo gait analysis data, and an MRI scan of a foot from a healthy subject were acquired and used to develop a six degrees of freedom (6 DOF) foot MSM and a 3D subject-specific foot FEM. Ankle kinematics were applied as boundary conditions to the FEM together with: 1. only Ground Reaction Forces (GRFs); 2. OpenSim derived extrinsic muscles forces estimated with a standard OpenSim MSM; 3. extrinsic muscle forces derived through the (6 DOF) foot MSM; 4. intrinsic and extrinsic muscles forces derived through the 6 DOF foot MSM. For model validation purposes, simulated peak pressures were extracted and compared with those measured experimentally. The importance of foot muscles in controlling plantar pressure distribution and internal stresses is confirmed by the improved accuracy in the estimation of the peak pressures obtained with the inclusion of intrinsic and extrinsic muscle forces. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Kiwifruit fibre level influences the predicted production and absorption of SCFA in the hindgut of growing pigs using a combined in vivo-in vitro digestion methodology.

    Science.gov (United States)

    Montoya, Carlos A; Rutherfurd, Shane M; Moughan, Paul J

    2016-04-01

    Combined in vivo (ileal cannulated pig) and in vitro (faecal inoculum-based fermentation) digestion methodologies were used to predict the production and absorption of SCFA in the hindgut of growing pigs. Ileal and faecal samples were collected from animals (n 7) fed diets containing either 25 or 50 g/kg DM of kiwifruit fibre from added kiwifruit for 14 d. Ileal and faecal SCFA concentrations normalised for food DM intake (DMI) and nutrient digestibility were determined. Ileal digesta were collected and fermented for 38 h using a fresh pig faecal inoculum to predict SCFA production. The predicted hindgut SCFA production along with the determined ileal and faecal SCFA were then used to predict SCFA absorption in the hindgut and total tract organic matter digestibility. The determined ileal and faecal SCFA concentrations (e.g. 8·5 and 4·4 mmol/kg DMI, respectively, for acetic acid for the low-fibre diet) represented only 0·2-3·2 % of the predicted hindgut SCFA production (e.g. 270 mmol/kg DMI for acetic acid). Predicted production and absorption of acetic, butyric and propionic acids were the highest for the high-fibre diet (P0·05). In conclusion, determined ileal and faecal SCFA concentrations represent only a small fraction of total SCFA production, and may therefore be misleading in relation to the effect of diets on SCFA production and absorption. Considerable quantities of SCFA are produced and absorbed in the hindgut of the pig by the fermentation of kiwifruit.

  7. Measuring Consumer Innovativeness: Identifying Innovators among Consumers of Modern Technologies

    Directory of Open Access Journals (Sweden)

    Jana Filová

    2015-12-01

    Full Text Available The methods currently used in innovation marketing research are focused on the late phases of the innovation process and are usually methodologically complex. This limits their practical impact. The presented work aims to create a simple self-report scale applicable in the initial and late phases of the innovation process, highly modular and suitable for a wide range of research. The main battery of questions was inspired by the adopter categorization by Rogers. The questions determine both (1 general characteristics of innovation adopters and (2 their relationship to a specific innovation. The scale was tested during robust longitudinal online research, thematically focused on users of modern technologies. A representative sample of 4,000 Internet users in the Czech Republic took part in the survey from 2013 to 2015. The result is a new self-report scale measuring consumer innovativeness applicable for prototyping, strategic decisions and effective communication of innovations to consumers.

  8. Strategic innovation portfolio management

    Directory of Open Access Journals (Sweden)

    Stanković Ljiljana

    2015-01-01

    Full Text Available In knowledge-based economy, strategic innovation portfolio management becomes more and more important and critical factor of enterprise's success. Value creation for all the participants in value chain is more successful if it is based on efficient resource allocation and improvement of innovation performances. Numerous researches have shown that companies with best position on the market found their competitiveness on efficient development and exploitation of innovations. In decision making process, enterprise's management is constantly faced with challenge to allocate resources and capabilities as efficiently as possible, in both short and long term. In this paper authors present preliminary results of realized empirical research related to strategic innovation portfolio management in ten chosen enterprises in Serbia. The structure of the paper includes the following parts: theoretical background, explanation of research purpose and methodology, discussion of the results and concluding remarks, including limitations and directions for further research.

  9. Service innovation in China

    DEFF Research Database (Denmark)

    Slepniov, Dmitrij; Jin, Jun

    2014-01-01

    Purpose – The aim of this paper is to advance our understanding of service innovation in China and to identify the major drivers and impediments for manufacturing companies pushing into services in China. Design/methodology/approach – By employing an in-depth longitudinal case of a Chinese company...... Chinese cities. Both internal and external factors played a significant role in influencing the development and implementation of service innovation in the case. The paper details and discusses the factors that affect service innovation in China. Research Limitations – The study is exposed...... in informing our expectations about the push of many Chinese manufacturing companies into services. The paper provides insights into the development and diffusion of service innovation in many fast transforming industrial companies in China. Lessons for other developing countries can also be drawn from...

  10. Process innovation laboratory

    DEFF Research Database (Denmark)

    Møller, Charles

    2007-01-01

    to create a new methodology for developing and exploring process models and applications. The paper outlines the process innovation laboratory as a new approach to BPI. The process innovation laboratory is a comprehensive framework and a collaborative workspace for experimenting with process models....... The process innovation laboratory facilitates innovation by using an integrated action learning approach to process modelling in a controlled environment. The study is based on design science and the paper also discusses the implications to EIS research and practice......Most organizations today are required not only to operate effective business processes but also to allow for changing business conditions at an increasing rate. Today nearly every business relies on their enterprise information systems (EIS) for process integration and future generations of EIS...

  11. How do innovators stay innovative? A longitudinal case analysis

    OpenAIRE

    Tuzovic, Sven; Wirtz, Jochen; Heracleous, Loizos Th.

    2018-01-01

    Purpose – How can some companies be the innovation leader in their industry over prolonged periods of time, while others cannot? The purpose of this study is to understand a firm’s capability to be a successful serial innovator and to generate a constant stream of industry-leading innovations.\\ud \\ud Design/Methodology/Approach – The paper uses a longitudinal case study approach to gain an understanding of what and how Singapore Airlines (SIA) sustained service innovation for over 30 years. T...

  12. FM Innovation in Science and Practice

    NARCIS (Netherlands)

    Mobach, Mark P.; Nardelli, Giulia; Konkol, Jennifer; Kok, Herman B.; Alexander, Keith; Alexander, Keith; Price, Ilfryn

    2015-01-01

    Purpose: To report in FM Innovation. Theory: Innovation theory, service management, space design. Design/methodology/approach: Case studies, workshop. Findings: Barriers, areas of interest, and best practices in FM Innovation. Originality/value: Presents a first exploration of European case

  13. FM Innovation in Science and Practice

    DEFF Research Database (Denmark)

    Mobach, Mark P.; Nardelli, Giulia; Konkol, Jennifer

    2015-01-01

    Purpose : To report in FM Innovation. Theory : Innovation theory, service management, space design. Design/methodology/approach : Case studies, workshop. Findings : Barriers, areas of interest, and best practices in FM Innovation. Originality/value : Presents a first exploration of European case...

  14. Social innovation, the new challenge for Europe

    NARCIS (Netherlands)

    Pot, F.; Vaas, F.

    2008-01-01

    Purpose - This study sets out to describe activities within The Netherlands Centre for Social Innovation, one of the earliest national bodies to promote and develop the concept of social innovation. Design/methodology/approach - The paper describes the concept of social innovation and then

  15. Impact of Innovation on Consumers Liking and Willingness to Pay for Traditional Sausages

    Directory of Open Access Journals (Sweden)

    Żakowska-Biemans Sylwia

    2016-06-01

    Full Text Available The main objective of the study was to evaluate Polish consumers’ liking and willingness to pay for innovations in traditional sausages “Kabanos”. The study also attempted to determine whether regional differences may influence acceptance of innovations and the willingness to pay for such products. As both sensory factors and prices are important in food choice decisions, the methodological approach combined hedonic liking and experimental auctions. The study involved 221 consumers of traditional pork sausages who evaluated intrinsic and extrinsic product attributes in blind (tasting only, expectancy (product information only and fully informed (tasting and product information experimental conditions. The results show that acceptance of innovation in traditional sausages is determined by the type of innovation proposed. Innovation related to extrinsic attributes like packaging i.e. biodegradable packaging seem to be the most welcome regardless experimental conditions while innovations improving healthiness of traditional sausages but violating their sensory properties i.e. lower salt level tend to be disapproved. There are regional differences observed in acceptance and willingness to pay for innovative variants of Kabanos. In general, consumers in Warsaw are more inclined to pay more for innovative variants of Kabanos than consumers in Cracow. Participants from the two regions had also different hedonic reactions towards organic and spicy variant of Kabanos. Prior research concerning acceptance of innovation in traditional food products in Poland is scarce. Therefore, such information is particularly pertinent to SMEs and distributors operating in traditional food sector to support innovation and development of adequate communication strategies.

  16. Bottom-linked innovation

    DEFF Research Database (Denmark)

    Kristensen, Catharina Juul

    2018-01-01

    hitherto been paid little explicit attention, namely collaboration between middle managers and employees in innovation processes. In contrast to most studies, middle managers and employees are here both subjects of explicit investigation. The collaboration processes explored in this article are termed...... ‘bottom-linked innovation’. The empirical analysis is based on an in-depth qualitative study of bottom-linked innovation in a public frontline institution in Denmark. By combining research on employee-driven innovation and middle management, the article offers new insights into such collaborative......Employee-driven innovation is gaining ground as a strategy for developing sustainable organisations in the public and private sector. This type of innovation is characterised by active employee participation, and the bottom-up perspective is often emphasised. This article explores an issue that has...

  17. Science Innovation

    Science.gov (United States)

    EPA provides innovative research activities that help transform the protection of human health and the environment with high-risk, high-reward Pathfinder Innovation Projects, the P3 student competition, and low-cost air monitoring.

  18. Technology Innovation

    Science.gov (United States)

    EPA produces innovative technologies and facilitates their creation in line with the Agency mission to create products such as the stormwater calculator, remote sensing, innovation clusters, and low-cost air sensors.

  19. Removal of Penicillin G by combination of sonolysis and Photocatalytic (sonophotocatalytic) process from aqueous solution: process optimization using RSM (Response Surface Methodology).

    Science.gov (United States)

    Almasi, Ali; Dargahi, Abdollah; Mohamadi, Mitra; Biglari, Hamed; Amirian, Farhad; Raei, Mehdi

    2016-09-01

    Penicillin G (PG) is used in a variety of infectious diseases, extensively. Generally, when antibiotics are introduced into the food chain, they pose a threat to the environment and can risk health outcomes. The aim of the present study was the removal of Penicillin G from an aqueous solution through an integrated system of UV/ZnO and UV/WO 3 with Ultrasound pretreatment. In this descriptive-analytical work dealing with the removal of Penicillin G from an aqueous solution, four significant variables, contact time (60-120 min), Penicillin G concentration (50-150 mg/L), ZnO dose (200-400 mg/L), and WO 3 dose (100-200 mg/L) were investigated. Experiments were performed in a Pyrex reactor (batch, 1 Lit) with an artificial UV 100-Watt medium pressure mercury lamp, coupled with ultrasound (100 W, 40 KHz) for PG pre-treatment. Chemical Oxygen Demand (COD) was selected to follow the performance of the photo-catalytic process and sonolysis. The experiments were based on a Central Composite Design (CCD) and analyzed by Response Surface Methodology (RSM). A mathematical model of the process was designed according to the proposed degradation scheme. The results showed that the maximum removal of PG occurred in ultrasonic/UV/WO 3 in the presence of 50 mg/L WO 3 and contact time of 120 minutes. In addition, an increase in the PG concentration caused a decrease in COD removal. As the initial concentration of the catalyst increased, the COD removal also increased. The maximum COD removal (91.3%) achieved by 200 mg/L WO 3 and 400 mg/l ZnO, a contact time of 120 minutes, and an antibiotic concentration of 50 mg/L. All of the variables in the process efficiency were found to be significant (p research data supported the conclusion that the combination of advanced oxidation process of sonolysis and photocatalytic (sonophotocatalytic) were applicable and environmentally friendly processes, which preferably can be applied extensively.

  20. Methodology for Innovation Policies Impact Assessment

    DEFF Research Database (Denmark)

    Gelsing, Lars

    2006-01-01

    Rapporten beskriver det teoretiske grundlag for at undersøge effekterne af innovationspolitik på regionalt niveau i EU. Endvidere skitseres en fremgangsmåde til at undersøge regionerns klyngedannelse og netværksudvikling...

  1. Political innovations

    DEFF Research Database (Denmark)

    Sørensen, Eva

    2017-01-01

    are mainly interested in assessing and promoting innovations in public service delivery, but have paid little or no attention to the need for innovations in polity, politics and policy. This article develops a research agenda for studying innovations in political institutions, in the political process...... and in policy outputs. It proposes a number of research themes related to political innovations that call for scholarly attention, and identifies push and pull factors influencing the likelihood that these themes will be addressed in future research....

  2. Global Methodology to Integrate Innovative Models for Electric Motors in Complete Vehicle Simulators Méthodologie générale d’intégration de modèles innovants de moteurs électriques dans des simulateurs véhicules complets

    Directory of Open Access Journals (Sweden)

    Abdelli A.

    2011-11-01

    Full Text Available By what means the greenhouse gas emissions of passenger cars can be reduced to 120 g/km in 2012 and 95 g/km in 2020 as the European Commission and the automotive manufacturers are stated? This question with multi answers preoccupies at the moment the whole automobile world. One of the most promising solutions which receive attention is the electrification of the vehicle. It is this idea that has prompted the automobile manufacturers to envisage increasingly innovative hybrid vehicles. However, this theoretically interesting solution makes more complex the powertrain, which requires the use of simulation tools in order to reduce the cost and the time of system development. System simulation, which is already a crucial tool for the design process of internal combustion engines, becomes indispensable in the development of the Hybrid Electric Vehicle (HEV. To study the complex structures of HEV, following the example of the physical models developed for the internal combustion engine, system simulation has to provide itself of the same predictive models for electric machines. From their specifications, these models have to take into account the strict constraint on the time simulation. This constraint guarantees the wide use of simulators, notably to help the development and the validation of control strategies. This paper aims to present a global methodology to develop innovative models of electrical machines. The final objective of these models is to be integrated in a global vehicle simulator. This methodology includes several types of models and tools, as Finite Elements Models (FEM, characterization and simulating models. This methodology was applied successfully to model an internal permanent magnet synchronous motors. At the end of the modelling process of the electric motor, the latter has been integrated in a complete global hybrid vehicle. This guarantees the good operation and integration in the global process of a new vehicle concept

  3. Nonlinear Image Denoising Methodologies

    National Research Council Canada - National Science Library

    Yufang, Bao

    2002-01-01

    In this thesis, we propose a theoretical as well as practical framework to combine geometric prior information to a statistical/probabilistic methodology in the investigation of a denoising problem...

  4. Innovation hubs

    DEFF Research Database (Denmark)

    O´Hara, J.; Hansen, Poul H. Kyvsgård; Turner, N.

    2008-01-01

    "Whilst ‘incremental innovation' is an imperative for the short-to-medium term success of a company, there is also a need for companies to engage in innovation activity that goes beyond the incremental in order to guarantee long-term success. However, such ‘radical innovation' (RI) poses new chal...

  5. Brugerdreven innovation

    DEFF Research Database (Denmark)

    Helms, Niels Henrik; Larsen, Lasse Juel

    2007-01-01

    På et generelt plan er vores afsæt et opgør med traditionelle modeller for kreativitet og innovation. Artiklen mener, at brugerdreven innovation ikke bare en god idé, men en beskrivelse af, hvordan innovation finder sted. Vores afsæt er interaktionsdesign, hvor vi bygger på den antagelse...

  6. Service co-innovation

    DEFF Research Database (Denmark)

    Henten, Anders; Sundbo, Jon; Sundbo, Donna

    of studies of the degree of satisfaction of the users with the services in the service encounters and studies that examine service innovation processes. The paper is based on research conducted in 21 service delivery situations in as many service companies. Drivers of and barriers to encounterbased service......This paper examines the factors affecting the innovativeness of service encounters. The assumption is that a considerable share of innovations in service industries is initiated in the service encounters. The theoretical foundation of this paper builds on a combination of research tradition...

  7. Staging Collaborative Innovation Processes

    DEFF Research Database (Denmark)

    Pedersen, Signe; Clausen, Christian

    Organisations are currently challenged by demands for increased collaborative innovation internally as well as with external and new entities - e.g. across the value chain. The authors seek to develop new approaches to managing collaborative innovative processes in the context of open innovation ...... the diverse matters of concern into a coherent product or service concept, and 2) in the same process move these diverse holders of the matters of concern into a translated actor network which carry or support the concept.......Organisations are currently challenged by demands for increased collaborative innovation internally as well as with external and new entities - e.g. across the value chain. The authors seek to develop new approaches to managing collaborative innovative processes in the context of open innovation...... and public private innovation partnerships. Based on a case study of a collaborative design process in a large electronics company the paper points to the key importance of staging and navigation of collaborative innovation process. Staging and navigation is presented as a combined activity: 1) to translate...

  8. Development and upscaling of integral sustainable energy innovations in housing : the role of practice and underlying drivers, combining theoretical perspectives for a new research agenda

    NARCIS (Netherlands)

    Hofman, Petra; Hoppe, Thomas

    2013-01-01

    The goal of this paper is to elaborate a theoretical framework and research design for further research related to the question ‘What practices and underlying drivers explain adoption of integral sustainable energy innovations in the Dutch housing sector?’. Although there are many efforts to speed

  9. Framing Innovation

    DEFF Research Database (Denmark)

    Haase, Louise Møller; Laursen, Linda Nhu

    2017-01-01

    Designing a remarkable product innovation is a difficult challenge, which businesses today continuously are striving to tackle. This challenge is particularly present in the early phase of innovation, where the main product concept and frames of the innovation is determined. As a main challenge...... in the early phase is the reasoning process; innovation team are faced with open- ended ill-defines problems, where they need to make decisions about an unknown future having only incomplete, ambiguous and contradicting insights available. We study the reasoning of experts, how they frame to make sense of all...... the insights and create a basis for decision making in relation to a new project. Based on case studies of five innovative products from various industries, we suggest a Product Reasoning Model for understanding reasoning and envisioning of new product innovations in the early phases of innovation....

  10. Business dominant position in innovation process

    OpenAIRE

    BABYCH T.O.

    2015-01-01

    In the international competitive environment innovative development acquires the special urgency for the nation. Innovation is no longer seen as a stochastic process. was The systematic implementation and stimulation of innovation have become the paradigm of economic development for the most of the world. It is important to form and to exploit new methodologies and tools for innovation policy. Such instruments should cover all the factors and results. So the large and small business should be...

  11. Evaluating the impact of public space investments with limited time and funds: (methodological) lessons from a Swiss case study

    Energy Technology Data Exchange (ETDEWEB)

    Barjak, F.

    2016-07-01

    The paper suggests a methodology for evaluating innovation support policies and funding in the space sector. Previous evaluations have suggested methodologies which require considerable time and resources. Our approach combines a data collection at organisational level through standardised interviews and at project level through an online survey which are relatively quick to implement and less costly. We demonstrate that valid results can be obtained with such an approach. (Author)

  12. Multi-Population Invariance with Dichotomous Measures: Combining Multi-Group and MIMIC Methodologies in Evaluating the General Aptitude Test in the Arabic Language

    Science.gov (United States)

    Sideridis, Georgios D.; Tsaousis, Ioannis; Al-harbi, Khaleel A.

    2015-01-01

    The purpose of the present study was to extend the model of measurement invariance by simultaneously estimating invariance across multiple populations in the dichotomous instrument case using multi-group confirmatory factor analytic and multiple indicator multiple causes (MIMIC) methodologies. Using the Arabic version of the General Aptitude Test…

  13. Formalizing the ISDF Software Development Methodology

    Directory of Open Access Journals (Sweden)

    Mihai Liviu DESPA

    2015-01-01

    Full Text Available The paper is aimed at depicting the ISDF software development methodology by emphasizing quality management and software development lifecycle. The ISDF methodology was built especially for innovative software development projects. The ISDF methodology was developed empirically by trial and error in the process of implementing multiple innovative projects. The research process began by analysing key concepts like innovation and software development and by settling the important dilemma of what makes a web application innovative. Innovation in software development is presented from the end-user, project owner and project manager’s point of view. The main components of a software development methodology are identified. Thus a software development methodology should account for people, roles, skills, teams, tools, techniques, processes, activities, standards, quality measuring tools, and team values. Current software development models are presented and briefly analysed. The need for a dedicated innovation oriented software development methodology is emphasized by highlighting shortcomings of current software development methodologies when tackling innovation. The ISDF methodology is presented in the context of developing an actual application. The ALHPA application is used as a case study for emphasizing the characteristics of the ISDF methodology. The development life cycle of the ISDF methodology includes research, planning, prototyping, design, development, testing, setup and maintenance. Artefacts generated by the ISDF methodology are presented. Quality is managed in the ISDF methodology by assessing compliance, usability, reliability, repeatability, availability and security. In order to properly asses each quality component a dedicated indicator is built. A template for interpreting each indicator is provided. Conclusions are formulated and new related research topics are submitted for debate.

  14. Scenario development methodologies

    International Nuclear Information System (INIS)

    Eng, T.; Hudson, J.; Stephansson, O.

    1994-11-01

    In the period 1981-1994, SKB has studied several methodologies to systematize and visualize all the features, events and processes (FEPs) that can influence a repository for radioactive waste in the future. All the work performed is based on the terminology and basic findings in the joint SKI/SKB work on scenario development presented in the SKB Technical Report 89-35. The methodologies studied are a) Event tree analysis, b) Influence diagrams and c) Rock Engineering Systems (RES) matrices. Each one of the methodologies is explained in this report as well as examples of applications. One chapter is devoted to a comparison between the two most promising methodologies, namely: Influence diagrams and the RES methodology. In conclusion a combination of parts of the Influence diagram and the RES methodology is likely to be a promising approach. 26 refs

  15. Multifunctionality of forestry as basis for creating gross innovational forestry product

    Directory of Open Access Journals (Sweden)

    Nikolai Mikhailovich Bolshakov

    2013-06-01

    Full Text Available The article is devoted to theoretical and methodological issues of defining the essence, role and place of multifunctional forest economy (MFFE from the perspective of the scientific rationale of the state forest policy, which contributes to transference of the forest sector to the innovative basis with the emphasis on the regeneration issues. The system-regeneration approach is used as a methodological tool, which is the combination of principles and analysis of the forest sector as a complicated social-economical system based on the methodology of the regeneration process. On the basis of objective economic laws and regulations, a political-economic analysis is carried out to find out the system interrelation of the quality of forest resource use and productivity of social labour in the forest sector. Common features in the circulation of the functions of forestry capable of creating a special form of an innovation, gross innovational forestry product are identified. A model of a multifunctional forestry providing an opportunity to predict the characteristics of innovational products in complex systems is suggested. This model makes the basis for research of the innovative changes potentional for modernization of the innovative forest product.

  16. Mapping your innovation strategy.

    Science.gov (United States)

    Anthony, Scott D; Eyring, Matt; Gibson, Lib

    2006-05-01

    In the complex sport of American football, teams rely on playbooks as thick as the Manhattan phone directory. But when it comes to creating innovative growth businesses-which is at least as complicated as professional football--most companies have not developed detailed game plans. Indeed, many managers have concluded that a fog enshrouds the world of innovation, obscuring high-potential opportunities. The authors believe that companies can penetrate that fog by developing growth strategies based on disruptive innovations, as defined by Clayton Christensen. Such innovations conform to a pattern: They offer an entirely new solution; they perform adequately along traditional dimensions and much better along other dimensions that matter more to target customers; and they are not initially appealing to powerful incumbents. Companies can develop customized checklists, or playbooks, by combining this basic pattern with analysis of major innovations in their markets. The key early on is to focus not on detailed financial estimates--which will always guide companies toward the markets most hostile to disruptive innovations--but on how well the innovation fits the pattern of success. It's also crucial to encourage flexibility: Companies must be willing to kill projects that are going nowhere, exempt innovations from standard development processes, and avoid burdening project teams with extra financing, which can keep them heading in the wrong direction. Companies can create competitive advantage by becoming champions at defining the pattern of successful innovations and executing against it. But as that pattern becomes obvious--and others emerge-building a sustainable advantage on innovation competencies will again prove elusive.

  17. Framing Innovation

    DEFF Research Database (Denmark)

    Haase, Louise Møller; Laursen, Linda Nhu

    2017-01-01

    Designing a remarkable product innovation is a difficult challenge, which businesses today continuously are striving to tackle. This challenge is particularly present in the early phase of innovation, where the main product concept and frames of the innovation is determined. As a main challenge...... in the early phase is the reasoning process; innovation team are faced with open-ended ill-defines problems, where they need to make decisions about an unknown future having only incomplete, ambiguous and contradicting insights available. We study the reasoning of experts, how they frame to make sense of all...... the insights and create a basis for decision making in relation to a new project. Based on case studies of five innovative products from various industries, we suggest a Product Reasoning Model for understanding reasoning and envisioning of new product innovations in the early phases...

  18. Sensitive innovation

    DEFF Research Database (Denmark)

    Søndergaard, Katia Dupret

    Present paper discusses sources of innovation as heterogenic and at times intangible processes. Arguing for heterogeneity and intangibility as sources of innovation originates from a theoretical reading in STS and ANT studies (e.g. Callon 1986, Latour 1996, Mol 2002, Pols 2005) and from field work...... in the area of mental health (Dupret Søndergaard 2009, 2010). The concept of sensitive innovation is developed to capture and conceptualise exactly those heterogenic and intangible processes. Sensitive innovation is therefore primarily a way to understand innovative sources that can be......, but are not necessarily, recognized and acknowledged as such in the outer organisational culture or by management. The added value that qualifies these processes to be defined as “innovative” are thus argued for along different lines than in more traditional innovation studies (e.g. studies that build on the classic...

  19. Logistics innovation development

    DEFF Research Database (Denmark)

    Pedrosa, Alex; Blazevic, Vera; Jasmand, Claudia

    2014-01-01

    to investigate the role of boundary-spanning employees in deepening and broadening customer knowledge while developing logistics service innovations. Findings The results show that boundary-spanning employees’ engage sequentially in deepening and broadening customer knowledge throughout the logistics innovation...... development process. In particular it shows that deepening customer knowledge tends to occur in one-to-one interactions. When boundary-spanning employees engage in broadening customer knowledge, they develop a rich understanding of current customer. Research limitations/implications (if applicable) In general......Purpose This paper aims to investigate the microfoundations—boundary-spanning employees activities and behaviors—of deepening and broadening customer knowledge during logistics innovation development. Design/methodology/approach A multiple case study approach (six case studies) was adopted...

  20. Employee-driven innovation

    DEFF Research Database (Denmark)

    Kesting, Peter; Ulhøi, John Parm

    2015-01-01

    Purpose – The purpose of this paper is to outline the “grand structure” of the phenomenon in order to identify both the underlying processes and core drivers of employee-driven innovation (EDI). Design/methodology/approach – This is a conceptual paper. It particularly applies the insights...... of contemporary research on routine and organizational decision making to the specific case of EDI. Findings – The main result of the paper is that, from a theoretical point of view, it makes perfect sense to involve ordinary employees in innovation decisions. However, it is also outlined that naıve or ungoverned...... participation is counterproductive, and that it is quite difficult to realize the hidden potential in a supportive way. Research limitations/implications – The main implication is that basic mechanisms for employee participation also apply to innovation decisions, although often in a different way. However...

  1. Commercializing Government-sponsored Innovations: Twelve Successful Buildings Case Studies

    Science.gov (United States)

    Brown, M. A.; Berry, L. G.; Goel, R. K.

    1989-01-01

    This report examines the commercialization and use of R and D results funded by DOE's Office of Buildings and Community Systems (OBCS), an office that is dedicated to improving the energy efficiency of the nation's buildings. Three goals guided the research described in this report: to improve understanding of the factors that hinder or facilitate the transfer of OBCS R and D results, to determine which technology transfer strategies are most effective and under what circumstances each is appropriate, and to document the market penetration and energy savings achieved by successfully-commercialized innovations that have received OBCS support. Twelve successfully-commercialized innovations are discussed here. The methodology employed involved a review of the literature, interviews with innovation program managers and industry personnel, and data collection from secondary sources. Six generic technology transfer strategies are also described. Of these, contracting R and D to industrial partners is found to be the most commonly used strategy in our case studies. The market penetration achieved to date by the innovations studied ranges from less than 1% to 100%. For the three innovations with the highest predicted levels of energy savings (i.e., the flame retention head oil burner, low-E windows, and solid-state ballasts), combined cumulative savings by the year 2000 are likely to approach 2 quads. To date the energy savings for these three innovations have been about 0.2 quads. Our case studies illustrate the important role federal agencies can play in commercializing new technologies.

  2. On managing innovation by design : Towards SMART methods

    NARCIS (Netherlands)

    Vermaas, P.E.

    2012-01-01

    In this paper innovation by design is characterised schematically and methodological with the aim of analysing how projects of innovation by design can be managed. First, I approach innovation by design from an engineering perspective, and show that the incorporation of innovation into design

  3. Financing Innovation

    OpenAIRE

    William R. Kerr; Ramana Nanda

    2014-01-01

    We review the recent literature on the financing of innovation, inclusive of large companies and new startups. This research strand has been very active over the past five years, generating important new findings, questioning some long-held beliefs, and creating its own puzzles. Our review outlines the growing body of work that documents a role for debt financing related to innovation. We highlight the new literature on learning and experimentation across multi-stage innovation projects and h...

  4. Supplier Innovation

    DEFF Research Database (Denmark)

    Søberg, Peder Veng; Notman, Dorian Mark; Wæhrens, Brian Vejrum

    2017-01-01

    The prevailing research in supplier innovation has been conceptual or based on small data sets. The analysis of a large data set gives a clearer perspective on the actual type and degree of involvement of suppliers in the customer’s innovation process. The supplier perspective of the research...... counterbalances the customer bias that exists in the prevailing literature in this area. Similarly, the issue of the benefit of supplier involvement in the innovation/NPD process can be better understood. Manufacturing suppliers benefit financially from their involvement in the innovation/NPD process of their key...

  5. Responsive Innovation

    DEFF Research Database (Denmark)

    Pedersen, Carsten

    Although the importance of stakeholder networks has been recognized in recent years, a non-teleological model that incorporates their collective sensing into innovation processes has so far not been developed. Hence, this paper argues that traditional linear and sequential innovation models...... are insufficient in hypercompetitive environments. Instead, it is proposed that companies should ground their innovation processes in the collective sensing of frontline-employees and customers that operate around the organizational periphery. This frames the concept of responsive innovation, where key...... stakeholders engaged in the organization’s ongoing business activities collectively identify issues that central managers subsequently can resolve....

  6. Innovation @ NASA

    Science.gov (United States)

    Roman, Juan A.

    2014-01-01

    This presentation provides an overview of the activities National Aeronautics and Space Administration (NASA) is doing to encourage innovation across the agency. All information provided is available publicly.

  7. Long-term forecasting of electric load within overall energy demand by the use of the combined MAED and WASP methodologies

    International Nuclear Information System (INIS)

    Charpentier, J.P.; Molina, P.E.

    1983-01-01

    This paper describes the methodologies involved in carrying out an Energy and Nuclear Power Planning Study (ENPPS), with emphasis on the MAED Model. It outlines the necessary steps for successfully conducting such a study, and describes its advantages with reference to the Algerian study. The International Atomic Energy Agency (IAEA) will use this expertise in assisting developing Member States in the economic assessments of the role of nuclear energy within the national energy plan of the country. 6 references, 11 figures, 2 tables

  8. AUDIT OF INNOVATIVE IDEAS AS THE PREVIOUS STAGE OF THE BUSINESS-PLAN OF START-UP PROJECTS

    Directory of Open Access Journals (Sweden)

    O. Zhylinska

    2014-09-01

    Full Text Available The phenomenon of feasibility reasoning of venture capital investment for the implementation of innovative ideas is revealed. The main elements of the methodology for feasibility of start-up projects, based on the concept of combination of life cycle of the market, product innovation and startup companies, are characterized. The comparative analysis of methods feasibility study and business plan start-up project is made, the importance of innovative ideas audit in future economic information generation and investment decisions of informal venture capital investors are shown.

  9. Socio-Ecological Innovation

    DEFF Research Database (Denmark)

    Edgeman, Rick; Eskildsen, Jacob Kjær

    Socio‐Ecological Innovation or SEI is innovation resulting from strategic integration of sustainable innovation and innovation for sustainability. In particular SEI is regarded as critical to organizations intent on progressing toward Sustainable Enterprise Excellence (SEE) and, indeed, progressing......, how developed or mature it is, and how future SEI strategy and results can be improved. As an aid to these efforts, non‐prescriptive approaches to SEI are discussed, maturity scale assessment for SEI is developed and discussed, and a simple assessment report that combines graphic and narrative...... feedback is presented. The assessment report is referred to as a SEI News Report and is intended not only to provide feedback to the organization concerning its present SEI performance, but also to deliver significant foresight that will inform future SEI efforts, strengthening the likelihood...

  10. Subsidizing Media Innovation

    DEFF Research Database (Denmark)

    Kammer, Aske; Hobel, Emil

    When the Danish Parliament revised the media-subsidy framework in 2013/2014, one of the new initiatives was the introduction of a pool of funding earmarked to establishing and developing new news media – the so-called “innovation fund”. So, as the news industry struggles to keep journalism a viable...... and economically sustainable activity, the institutionalization of financial support for media innovation constitute one way for policy makers to bring (parts of) the journalistic environment up-to-date with the digital age, thereby improving the conditions for an informed citizenry in the future (Kammer...... scrutinizes the practical administration of the innovation fund in the first two years of its existence, analyzing all applications for innovation subsidies in 2014 and 2015 as well as all acceptance and rejection letters. With this empirical material and a combination of quantitative and qualitative...

  11. Bridging regional innovation

    DEFF Research Database (Denmark)

    Hansen, Teis

    2013-01-01

    to assess the progress of integration in the regions, as well as the effect of cross-border innovation policies. Consequently, important questions are left unanswered, including the central research question of this paper: does the sudden removal of significant physical barriers directly impacts......The topics of regional innovation systems (RIS) and cross-border regions attract increasing attention, but few studies combine the themes. Further, the existing empirical studies of cross-border innovation and knowledge creation analyse one case at one point in time, thus, making it difficult...... collaboration activity in cross-border innovation systems? This paper examines regional integration in the Oresund Region over time. It deals with a specific part of the RIS, as it analyses research collaboration between actors from the Danish and Swedish sides, with a specific emphasis on the biotech industry...

  12. Lessons for Co-Innovation in Agricultural Innovation Systems: A Multiple Case Study Analysis and a Conceptual Model

    Science.gov (United States)

    Fielke, Simon J.; Botha, Neels; Reid, Janet; Gray, David; Blackett, Paula; Park, Nicola; Williams, Tracy

    2018-01-01

    Purpose: This paper highlights important lessons for co-innovation drawn from three ex-post case study innovation projects implemented within three sub-sectors of the primary industry sector in New Zealand. Design/methodology/approach: The characteristics that fostered co-innovation in each innovation project case study were identified from…

  13. Leveraging External Sources of Innovation

    DEFF Research Database (Denmark)

    West, Joel; Bogers, Marcel

    2014-01-01

    , it suggests a four-phase model in which a linear process—(1) obtaining, (2) integrating, and (3) commercializing external innovations—is combined with (4) interaction between the firm and its collaborators. This model is used to classify papers taken from the top 25 innovation journals, complemented by highly...... cited work beyond those journals. A review of 291 open innovation-related publications from these sources shows that the majority of these articles indeed address elements of this inbound open innovation process model. Specifically, it finds that researchers have front-loaded their examination...... external innovations create value rather than how firms capture value from those innovations. Finally, the interaction phase considers both feedback for the linear process and reciprocal innovation processes such as cocreation, network collaboration, and community innovation. This review and synthesis...

  14. Game-like Technology Innovation Education

    DEFF Research Database (Denmark)

    Magnussen, Rikke

    2011-01-01

      The aim of this paper is to discuss the first results and methodological challenges and perspectives of designing game-inspired scenarios for implementation of innovation processes into schools' science education. This paper comprises and report on a case study of a game-inspired innovation...... scenario designed for technology education in grades 7 - 9 in Danish schools. In the paper, methodological challenges of doing design-based research into technology innovation education are discussed. The preliminary results from the first studies of a game-inspired technology innovation camp are also...... presented, along with discussions of the future of development of these educational spaces....

  15. Informal Innovation

    DEFF Research Database (Denmark)

    Hartmann, Mia Rosa Koss; Hartmann, Rasmus Koss

    Informal innovation, defined as the development and putting-into-use of novel solutions by non-R&D employees without prior formal approval from or subsequent revealing to superiors, has been recurrently observed in organizational research. But even as it is increasingly recognized that R&D is not......Informal innovation, defined as the development and putting-into-use of novel solutions by non-R&D employees without prior formal approval from or subsequent revealing to superiors, has been recurrently observed in organizational research. But even as it is increasingly recognized that R......&D is not the only plausible source of innovation inside organizations, informal innovation has yet to be systematically explored or theorized. We propose a theory of informal innovation based on analyses of prior literature and mixed-method, multi-site studies of innovation at the working level of two extreme......-case organizations. We propose that informal innovation occurs as 1) employees personally experience problems that they believe are not recognized or prioritized by superiors; 2) some employees are able to develop solutions, essentially at no cost; 3) innovators face no benefits from revealing to superiors, but can...

  16. Open innovation

    DEFF Research Database (Denmark)

    Bogers, Marcel; Chesbrough, Henry; Moedas, Carlos

    2018-01-01

    Open innovation is now a widely used concept in academia, business, and policy making. This article describes the state of open innovation at the intersection of research, practice, and policy. It discusses some key trends (e.g., digital transformation), challenges (e.g., uncertainty...

  17. Managing Innovation.

    Science.gov (United States)

    White, Ronald V.

    The management of innovation in instruction in English as a second language can benefit from the experience and techniques of management in the world of commerce as well as from theories and procedures in education. A systematic approach to the management of innovation emphasizes the importance of clearly defined objectives, evaluation that…

  18. Business Process Innovation using the Process Innovation Laboratory

    DEFF Research Database (Denmark)

    Møller, Charles

    for practical applications has not been identified. The aim of this paper is to establish a conceptual framework for business process innovation in the supply chain based on advanced enterprise systems. The main approach to business process innovation in this context is to create a new methodology for exploring...... process models and patterns of applications. The paper thus presents a new concept for business process innovation called the process innovation laboratory a.k.a. the ?-Lab. The ?-Lab is a comprehensive framework for BPI using advanced enterprise systems. The ?-Lab is a collaborative workspace...... for experimenting with process models and an explorative approach to study integrated modeling in a controlled environment. The ?-Lab facilitates innovation by using an integrated action learning approach to process modeling including contemporary technological, organizational and business perspectives....

  19. Understanding leachate flow in municipal solid waste landfills by combining time-lapse ERT and subsurface flow modelling - Part II: Constraint methodology of hydrodynamic models.

    Science.gov (United States)

    Audebert, M; Oxarango, L; Duquennoi, C; Touze-Foltz, N; Forquet, N; Clément, R

    2016-09-01

    Leachate recirculation is a key process in the operation of municipal solid waste landfills as bioreactors. To ensure optimal water content distribution, bioreactor operators need tools to design leachate injection systems. Prediction of leachate flow by subsurface flow modelling could provide useful information for the design of such systems. However, hydrodynamic models require additional data to constrain them and to assess hydrodynamic parameters. Electrical resistivity tomography (ERT) is a suitable method to study leachate infiltration at the landfill scale. It can provide spatially distributed information which is useful for constraining hydrodynamic models. However, this geophysical method does not allow ERT users to directly measure water content in waste. The MICS (multiple inversions and clustering strategy) methodology was proposed to delineate the infiltration area precisely during time-lapse ERT survey in order to avoid the use of empirical petrophysical relationships, which are not adapted to a heterogeneous medium such as waste. The infiltration shapes and hydrodynamic information extracted with MICS were used to constrain hydrodynamic models in assessing parameters. The constraint methodology developed in this paper was tested on two hydrodynamic models: an equilibrium model where, flow within the waste medium is estimated using a single continuum approach and a non-equilibrium model where flow is estimated using a dual continuum approach. The latter represents leachate flows into fractures. Finally, this methodology provides insight to identify the advantages and limitations of hydrodynamic models. Furthermore, we suggest an explanation for the large volume detected by MICS when a small volume of leachate is injected. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. MAPPING INNOVATION

    DEFF Research Database (Denmark)

    Thuesen, Christian Langhoff; Koch, Christian

    2011-01-01

    By adopting a theoretical framework from strategic niche management research (SNM) this paper presents an analysis of the innovation system of the Danish Construction industry. Theories within SNM look upon innovation in a sector as a socio-technical phenomenon and identifies three levels of socio......-technical interaction within which sectorial innovation can be explained. The analysis shows a multifaceted landscape of innovation around an existing regime, built in the existing ways of working and developing over generations. The regime is challenged from various niches and the sociotechnical landscape through...... trends as globalization. Three niches (Lean Construction, BIM and System Deliveries) are subject to a detailed analysis showing partly incompatible rationales and various degrees of innovation potential. The paper further discusses how existing policymaking operates in a number of tensions one being...

  1. Accidental Innovation

    DEFF Research Database (Denmark)

    Austin, Robert D.; Devin, Lee; Sullivan, Erin E.

    2012-01-01

    Historical accounts of human achievement suggest that accidents can play an important role in innovation. In this paper, we seek to contribute to an understanding of how digital systems might support valuable unpredictability in innovation processes by examining how innovators who obtain value from...... they incorporate accidents into their deliberate processes and arranged surroundings. By comparing makers working in varied conditions, we identify specific factors (e.g., technologies, characteristics of technologies) that appear to support accidental innovation. We show that makers in certain specified...... conditions not only remain open to accident but also intentionally design their processes and surroundings to invite and exploit valuable accidents. Based on these findings, we offer advice for the design of digital systems to support innovation processes that can access valuable unpredictability....

  2. Collaborative innovation

    DEFF Research Database (Denmark)

    Torfing, Jacob; Sørensen, Eva; Hartley, Jean

    2013-01-01

    , which emphasizes market competition; the neo-Weberian state, which emphasizes organizational entrepreneurship; and collaborative governance, which emphasizes multiactor engagement across organizations in the private, public, and nonprofit sectors. The authors conclude that the choice of strategies......-driven private sector is more innovative than the public sector by showing that both sectors have a number of drivers of as well as barriers to innovation, some of which are similar, while others are sector specific. The article then systematically analyzes three strategies for innovation: New Public Management......There are growing pressures for the public sector to be more innovative but considerable disagreement about how to achieve it. This article uses institutional and organizational analysis to compare three major public innovation strategies. The article confronts the myth that the market...

  3. Responsible innovation

    CERN Document Server

    De Woot, Philippe

    2015-01-01

    Economic development is rooted in disruption, not in equilibrium. And a powerful engine of economic development is innovation; but is this innovation always for the common good? The dark side of the extraordinary dynamism of innovation lies precisely in its destructive power. If simply left to market forces, it could lead to social chaos and great human suffering. To face the challenges of our time, we must create the proper climate and culture to develop strong entrepreneurial drive. But, more than ever, we must give this entrepreneurial drive its ethical and societal dimensions. Responsible innovation means a more voluntary orientation towards the great problems of the 21st century, e.g. depletion of the planet's resources, rising inequality, and new scientific developments potentially threatening freedom, democracy and human integrity. We need to transform our ceaseless creativity into real progress for humankind. In this respect, the rapid development of social innovation opens the door for new methods an...

  4. Service Innovation In Academic Libraries

    DEFF Research Database (Denmark)

    Scupola, Ada; Nicolajsen, Hanne Westh

    2010-01-01

    Purpose – The purpose of this article is to investigate whether management and employees in academic libraries involve users in library service innovations and what these user roles are. Design/methodology/approach – The article first reviews the literature focusing on innovation, new product...... development, new service development and library science with specific focus on users and management. Subsequently the research uses a case study approach to investigate management and customer involvement in a Danish academic library. Findings – Results from the case study show that academic libraries...... in academic library service innovations on the basis of an in-depth case study of a Danish academic library....

  5. Business Model Innovation in Airlines

    Directory of Open Access Journals (Sweden)

    Bruno Alencar Pereira

    2017-03-01

    Full Text Available The business models innovation in airlines can contribute to the creation of value, competitive advantage and profitability with new possibilities of action. The proposed paper aimed to identify the business models adopted by airlines and identify how the innovation occurs at these organizations. The methodology adopted is characterized as empirical, exploratory and descriptive research by multiple case study with three major Brazilian airlines. The results demonstrate that the search for paradigm breaks, related to the dichotomic traditional models of low-cost and full-service, toward hybrid business models occur linearly, as examples highlighted by companies, in which internal changes in business models are considered major organizational innovations.

  6. Nuclear innovation in Saskatchewan: innovation

    International Nuclear Information System (INIS)

    Alexander, N.

    2015-01-01

    This paper describes nuclear innovation in Saskatchewan. The first stage is the Canadian Institute for Science and Innovation Policy (CSIP) and how you have a successful discussion about a technically complex issue, understand what information people need in order to have an informed discussion, understand how to convey that information to those people in a constructive way.

  7. Participatory Innovation

    DEFF Research Database (Denmark)

    Buur, Jacob; Matthews, Ben

    2008-01-01

    An increasing number of corporations engage with users in co-innovation of products and services. But there are a number of competing perspectives on how best to integrate these understandings into existing corporate innovation development processes. This paper maps out three of the dominant appr...... the challenges such an approach sets to innovation management, and discuss research directions we see as fundamental to the development of the field of user-driven innovation. Udgivelsesdato: September......An increasing number of corporations engage with users in co-innovation of products and services. But there are a number of competing perspectives on how best to integrate these understandings into existing corporate innovation development processes. This paper maps out three of the dominant...... approaches, compares them in terms of goals, methods and basic philosophy, and shows how they may beneficially enrich one another. We will present an industrial innovation case that has been instrumental to the development of what we have termed ‘Participatory Innovation’. Based on this we will list...

  8. Investigation and incorporation of water inflow uncertainties through stochastic modelling in a combined optimisation methodology for water allocation in Alfeios River (Greece)

    Science.gov (United States)

    Bekri, Eleni; Yannopoulos, Panayotis; Disse, Markus

    2014-05-01

    The Alfeios River plays a vital role for Western Peloponnisos in Greece from natural, ecological, social and economic aspect. The main river and its six tributaries, forming the longest watercourse and the highest streamflow rate of Peloponnisose, represent a significant source of water supply for the region, aiming at delivering and satisfying the expected demands from a variety of water users, including irrigation, drinking water supply, hydropower production and recreation. In the previous EGU General Assembly, a fuzzy-boundary-interval linear programming methodology, based on Li et al. (2010) and Bekri et al. (2012), has been presented for optimal water allocation under uncertain and vague system conditions in the Alfeios River Basin. Uncertainties associated with the benefit and cost coefficient in the objective function of the main water uses (hydropower production and irrigation) were expressed as probability distributions and fuzzy boundary intervals derived by associated α-cut levels. The uncertainty of the monthly water inflows was not incorporated in the previous initial application and the analysis of all other sources of uncertainty has been applied to two extreme hydrologic years represented by a selected wet and dry year. To manage and operate the river system, decision makers should be able to analyze and evaluate the impact of various hydrologic scenarios. In the present work, the critical uncertain parameter of water inflows is analyzed and its incorporation as an additional type of uncertainty in the suggested methodology is investigated, in order to enable the assessment of optimal water allocation for hydrologic and socio-economic scenarios based both on historical data and projected climate change conditions. For this purpose, stochastic simulation analysis for a part of the Alfeios river system is undertaken, testing various stochastic models from simple stationary ones (AR and ARMA), Thomas-Fiering, ARIMA as well as more sophisticated and

  9. A new methodology for greenhouse gas reduction in industry through improved heat exchanging and/or integration of combined heat and power

    International Nuclear Information System (INIS)

    Axelsson, H.; Asblad, A.; Berntsson, T.

    1999-01-01

    This paper presents a method that identifies economically optimal combinations of enhanced heat recovery, integration of combined heat and power (CHP), and fuel switching, in an existing industrial energy system at various emission levels. Novel types of composite curves based on pinch technology, representing the existing temperature levels for supplying heat and the possible ones that may be attained after retrofitting, are used as tools for estimating the opportunities for CHP and the trade-off between improved heat exchanging and CHP. The method is explained by an example. (Copyright (c) 1999 Elsevier Science B.V., Amsterdam. All rights reserved.)

  10. Participatory Innovation

    DEFF Research Database (Denmark)

    Buur, Jacob; Matthews, Ben

    In this paper we discuss the potential for Participatory Design (PD) to make a fundamental contribution to the business-oriented field of user-driven innovation, taking note of where we find PD can best benefit from interaction with this other field. We examine some of the challenges that must...... be addressed if PD is to contribute to innovation processes in companies. We conclude by presenting a research agenda comprising of six promising topics to shape a new discipline of Participatory Innovation....

  11. Design & Innovation

    DEFF Research Database (Denmark)

    Boelskifte, Per; Jørgensen, Ulrik

    2005-01-01

    The new design and innovation programme at DTU is challenging some of the standard concepts dominating most engineering educations. The programme, its background, context and basic educational ideas are presented and discussed in this paper. To build competences that match the need for innovative...... and design oriented engineers in industry and society has turned out to challenge a number of the standard – and often taken for granted – concepts in engineering education still dominated world wide by rather strict norms and concepts of learning that do not challenge the students creativity and innovative...

  12. Feed in or certificates, competition or complementarity? Combining a static efficiency and a dynamic innovation perspective on the greening of the energy industry

    International Nuclear Information System (INIS)

    Midttun, Atle; Gautesen, Kristian

    2007-01-01

    European policy on the greening of the energy industry has been characterised by a debate between proponents of two apparent polar opposites, feed in tariffs and certificate markets. Different European countries have chosen both mechanisms and, as a consequence, the European Union has maintained a fairly pluralist position, abstaining from stricter harmonisation. Taking a dynamic innovation perspective on European energy industry, we argue that feed in tariffs and certificate markets should not be seen as competing alternatives, but rather as complementary regulatory instruments targeting subsequent steps in the product cycle, on the way from early technology-conceptualisation and development towards competitive positioning in mature energy markets. We see both policy instruments as necessary to achieve the extensive transformation towards sustainable development that is judged as important tools in the context of the global climate challenge

  13. Can Participatory Action Research Create Value for Business Model Innovation?

    DEFF Research Database (Denmark)

    Sparre, Mogens; Rasmussen, Ole Horn; Fast, Alf Michael

    Innovation (BMI)?” – has been investigated from five different perspectives based upon The Business Model Cube and The Where to Look Model. Using both established and newly developed tools the paper presents how. Theory and data from two cases are presented and it is demonstrated how industry increase......Abstract: Participatory Action Research (PAR) has a longer academic history compared with the idea of business models (BMs). This paper indicates how industries gain by using the combined methodology. The research question "Can participatory action research create value for Business Model...... their monetary and/or non-monetary value creation doing BMI based upon PAR. The process is essential and using the methodology of PAR creates meaning. Behind the process, the RAR methodology and its link to BM and BMI may contribute to theory construction and creation of a common language in academia around...

  14. Combined brain Fe, Cu, Zn and neurometabolite analysis - a new methodology for unraveling the efficacy of transcranial direct current stimulation (tDCS) in appetite control.

    Science.gov (United States)

    Ziomber, Agata; Surowka, Artur Dawid; Antkiewicz-Michaluk, Lucyna; Romanska, Irena; Wrobel, Pawel; Szczerbowska-Boruchowska, Magdalena

    2018-03-01

    Obesity is a chronic, multifactorial origin disease that has recently become one of the most frequent lifestyle disorders. Unfortunately, current obesity treatments seem to be ineffective. At present, transcranial direct current brain stimulation (tDCS) represents a promising novel treatment methodology that seems to be efficient, well-tolerated and safe for a patient. Unfortunately, the biochemical action of tDCS remains unknown, which prevents its widespread use in the clinical arena, although neurobiochemical changes in brain signaling and metal metabolism are frequently reported. Therefore, our research aimed at exploring the biochemical response to tDCS in situ, in the brain areas triggering feeding behavior in obese animals. The objective was to propose a novel neurochemical (serotoninergic and dopaminergic signaling) and trace metal analysis of Fe, Cu and Zn. In doing so, we used energy-dispersive X-ray fluorescence (EDXRF) and high-performance liquid chromatography (HPLC). Anodal-type stimulation (atDCS) of the right frontal cortex was utilized to down-regulate food intake and body weight gain in obese rats. EDXRF was coupled with the external standard method in order to quantify the chemical elements within appetite-triggering brain areas. Major dopamine metabolites were assessed in the brains, based on the HPLC assay utilizing the external standard assay. Our study confirms that elemental analysis by EDXRF and brain metabolite assay by HPLC can be considered as a useful tool for the in situ investigation of the interplay between neurochemical and Fe/Cu/Zn metabolism in the brain upon atDCS. With this methodology, an increase in both Cu and Zn in the satiety center of the stimulated group could be reported. In turn, the most significant neurochemical changes involved dopaminergic and serotoninergic signaling in the brain reward system.

  15. An ambient assisted living approach in designing domiciliary services combined with innovative technologies for patients with Alzheimer's disease: a case study.

    Science.gov (United States)

    Cavallo, Filippo; Aquilano, Michela; Arvati, Marco

    2015-02-01

    Alzheimer's disease (AD) is one of the most disabling diseases to affect large numbers of elderly people worldwide. Because of the characteristics of this disease, patients with AD require daily assistance from service providers both in nursing homes and at home. Domiciliary assistance has been demonstrated to be cost effective and efficient in the first phase of the disease, helping to slow down the course of the illness, improve the quality of life and care, and extend independence for patients and caregivers. In this context, the aim of this work is to demonstrate the technical effectiveness and acceptability of an innovative domiciliary smart sensor system for providing domiciliary assistance to patients with AD which has been developed with an Ambient Assisted Living (AAL) approach. The design, development, testing, and evaluation of the innovative technological solution were performed by a multidisciplinary team. In all, 15 sociomedical operators and 14 patients with AD were directly involved in defining the end-users' needs and requirements, identifying design principles with acceptability and usability features and evaluating the technological solutions before and after the real experimentation. A modular technological system was produced to help caregivers continuously monitor the health status, safety, and daily activities of patients with AD. During the experimentation, the acceptability, utility, usability, and efficacy of this system were evaluated as quite positive. The experience described in this article demonstrated that AAL technologies are feasible and effective nowadays and can be actively used in assisting patients with AD in their homes. The extensive involvement of caregivers in the experimentation allowed to assess that there is, through the use of the technological system, a proven improvement in care performance and efficiency of care provision by both formal and informal caregivers and consequently an increase in the quality of life of

  16. Isolation of dihydroatemisinic acid from the artemisia annua l. by-product by combining Ultrasound-assisted extraction with response surface methodology

    Science.gov (United States)

    Malaria is one of the world’s most important parasitic diseases, affecting 300-500 million people worldwide and killing more than one million per year. Artemisinin is currently the only raw material for the production of artemisinin combination therapies (ACT), the only medicine that cures drug-resi...

  17. Integrating Mixed Method Data in Psychological Research: Combining Q Methodology and Questionnaires in a Study Investigating Cultural and Psychological Influences on Adolescent Sexual Behavior

    Science.gov (United States)

    Franz, Anke; Worrell, Marcia; Vögele, Claus

    2013-01-01

    In recent years, combining quantitative and qualitative research methods in the same study has become increasingly acceptable in both applied and academic psychological research. However, a difficulty for many mixed methods researchers is how to integrate findings consistently. The value of using a coherent framework throughout the research…

  18. MAPPING INNOVATION

    DEFF Research Database (Denmark)

    Thuesen, Christian Langhoff; Koch, Christian

    2011-01-01

    By adopting a theoretical framework from strategic niche management research (SNM) this paper presents an analysis of the innovation system of the Danish Construction industry. The analysis shows a multifaceted landscape of innovation around an existing regime, built around existing ways of working...... and developed over generations. The regime is challenged from various niches and the socio-technical landscape through trends as globalization. Three niches (Lean Construction, BIM and System Deliveries) are subject to a detailed analysis showing partly incompatible rationales and various degrees of innovation...... potential. The paper further discusses how existing policymaking operates in a number of tensions one being between government and governance. Based on the concepts from SNM the paper introduces an innovation map in order to support the development of meta-governance policymaking. By mapping some...

  19. Innovation Awards

    Science.gov (United States)

    EPA promotes environmental stewardship by recognizing innovators in schools, communities and businesses in categories such as environmental education, green chemistry, smart growth, green power, and reducing air pollution and climate change impacts.

  20. Leadership Innovations

    Science.gov (United States)

    1993-04-01

    leadership " and " leadership in innovation." 3 THEORY , AS AN INSTRUMENT OF ANALYSIS FOR INNOVATION IN LEADERSHIP There are many...attributes of a leader.𔃺 Attempts to define leadership usually contrast it with "followship", management ," or sometimes - with ’beadship."’" These...plausible theory . - . . . -. - -- Nevertheless, some authors consider, and I agree, that there is no true leadership theory because existing

  1. THE FEATURES OF INNOVATION MANAGEMENT AT UKRAINIAN AND EUROPEAN ENTERPRISES

    OpenAIRE

    Yaroslav Panas; Solomiia Tkach

    2017-01-01

    The purpose of the paper is to define peculiarities of innovation management at enterprises in Ukraine and EU countries. Methodology. Based on European Innovation Scoreboard data a comparative assessment of innovation management have done through three aspects: 1) resource capacity, 2) prospects of business entities innovation activity; 3) innovation activity effectiveness. Analyse for Ukraine has done in comparison with average EU data and also with Poland and Germany. Results. In the articl...

  2. Predicting High or Low Transfer Efficiency of Photovoltaic Systems Using a Novel Hybrid Methodology Combining Rough Set Theory, Data Envelopment Analysis and Genetic Programming

    Directory of Open Access Journals (Sweden)

    Lee-Ing Tong

    2012-02-01

    Full Text Available Solar energy has become an important energy source in recent years as it generates less pollution than other energies. A photovoltaic (PV system, which typically has many components, converts solar energy into electrical energy. With the development of advanced engineering technologies, the transfer efficiency of a PV system has been increased from low to high. The combination of components in a PV system influences its transfer efficiency. Therefore, when predicting the transfer efficiency of a PV system, one must consider the relationship among system components. This work accurately predicts whether transfer efficiency of a PV system is high or low using a novel hybrid model that combines rough set theory (RST, data envelopment analysis (DEA, and genetic programming (GP. Finally, real data-set are utilized to demonstrate the accuracy of the proposed method.

  3. Directed Innovation of Business Models

    Directory of Open Access Journals (Sweden)

    Stelian Brad

    2016-06-01

    Full Text Available Business model innovation is an important issue to keep business competitive and increase company’s profits. Due to many market attractors, identification of appropriate paths of business model evolution is a painful and risky process. To improve decision’s effectiveness in this process, an architectural construct of analysis and conceptualization for business model innovation that combines directed evolution and blue ocean concepts is proposed in this paper under the name of directed innovation. It displays the key points where innovations would happen to direct adaptation of the business model towards sustainable competitiveness. Formulation of mature solutions is supported by inventive problem solving tools. The significance of the directed innovation approach is demonstrated in a case study dealing with business model innovation of a software company.

  4. Emerging Concepts and Methodologies in Cancer Biomarker Discovery.

    Science.gov (United States)

    Lu, Meixia; Zhang, Jinxiang; Zhang, Lanjing

    2017-01-01

    Cancer biomarker discovery is a critical part of cancer prevention and treatment. Despite the decades of effort, only a small number of cancer biomarkers have been identified for and validated in clinical settings. Conceptual and methodological breakthroughs may help accelerate the discovery of additional cancer biomarkers, particularly their use for diagnostics. In this review, we have attempted to review the emerging concepts in cancer biomarker discovery, including real-world evidence, open access data, and data paucity in rare or uncommon cancers. We have also summarized the recent methodological progress in cancer biomarker discovery, such as high-throughput sequencing, liquid biopsy, big data, artificial intelligence (AI), and deep learning and neural networks. Much attention has been given to the methodological details and comparison of the methodologies. Notably, these concepts and methodologies interact with each other and will likely lead to synergistic effects when carefully combined. Newer, more innovative concepts and methodologies are emerging as the current emerging ones became mainstream and widely applied to the field. Some future challenges are also discussed. This review contributes to the development of future theoretical frameworks and technologies in cancer biomarker discovery and will contribute to the discovery of more useful cancer biomarkers.

  5. Policy Innovation in Innovation Policy

    DEFF Research Database (Denmark)

    Borras, Susana

    During the past two decades Europe has experienced important changes and transformations in the way in which governments approach the issue of science, technology and innovation, and their relation to economic growth and competitiveness. This has to do with the European Union level as well...... as with national and sub-national governments in Europe, all of them introducing interesting novelties in their innovation policy. These changes refer to different aspects of policy, mainly the content of policy initiatives towards science, technology and innovation; the instruments governments are using...... at the EU level, and mentions similar trends taking place at national and sub-national levels. The questions that guide the contents here are essentially three, namely, what are the main traits of innovation policies in Europe since the 1990s and how have the EU and different national governments approached...

  6. Gamma-ray spectrometry combined with acceptable knowledge (GSAK). A technique for characterization of certain remote-handled transuranic (RH-TRU) wastes. Part 1. Methodology and techniques

    International Nuclear Information System (INIS)

    Hartwell, J.K.; McIlwain, M.E.

    2005-01-01

    Gamma-ray spectrometry combined with acceptable knowledge (GSAK) is a technique for the characterization of certain remote-handled transuranic (RH-TRU) wastes. GSAK uses gamma-ray spectrometry to quantify a portion of the fission product inventory of RH-TRU wastes. These fission product results are then coupled with calculated inventories derived from acceptable process knowledge to characterize the radionuclide content of the assayed wastes. GSAK has been evaluated and tested through several test exercises. GSAK approach is described, while test results are presented in Part II. (author)

  7. Game-like Technology Innovation Education

    DEFF Research Database (Denmark)

    Magnussen, Rikke

    2011-01-01

    scenario designed for technology education in grades 7 - 9 in Danish schools. In the paper, methodological challenges of doing design-based research into technology innovation education are discussed. The preliminary results from the first studies of a game-inspired technology innovation camp are also...

  8. Game-Like Technology Innovation Education

    Science.gov (United States)

    Magnussen, Rikke

    2011-01-01

    This paper examines the methodological challenges and perspectives of designing game-like scenarios for the implementation of innovation processes in school science education. This paper presents a design-based research study of a game-like innovation scenario designed for technology education for Danish public school students aged 13-15. Students…

  9. Investigating Teachers' Exploration of a Professional Development Website: An Innovative Approach to Understanding the Factors that Motivate Teachers to Use Internet-Based Resources

    Science.gov (United States)

    Beach, Pamela; Willows, Dale

    2014-01-01

    This qualitative study examined an innovative methodology, combining screen capture technology and a retrospective think aloud, for exploring the use of Internet-based resources by elementary teachers. Pre-service and in-service teachers explored "The Balanced Literacy Diet," a free, interactive, and evidenced-informed professional…

  10. A methodology to accurately quantify patellofemoral cartilage contact kinematics by combining 3D image shape registration and cine-PC MRI velocity data.

    Science.gov (United States)

    Borotikar, Bhushan S; Sipprell, William H; Wible, Emily E; Sheehan, Frances T

    2012-04-05

    Patellofemoral osteoarthritis and its potential precursor patellofemoral pain syndrome (PFPS) are common, costly, and debilitating diseases. PFPS has been shown to be associated with altered patellofemoral joint mechanics; however, an actual variation in joint contact stresses has not been established due to challenges in accurately quantifying in vivo contact kinematics (area and location). This study developed and validated a method for tracking dynamic, in vivo cartilage contact kinematics by combining three magnetic resonance imaging (MRI) techniques, cine-phase contrast (CPC), multi-plane cine (MPC), and 3D high-resolution static imaging. CPC and MPC data were acquired from 12 healthy volunteers while they actively extended/flexed their knee within the MRI scanner. Since no gold standard exists for the quantification of in vivo dynamic cartilage contact kinematics, the accuracy of tracking a single point (patellar origin relative to the femur) represented the accuracy of tracking the kinematics of an entire surface. The accuracy was determined by the average absolute error between the PF kinematics derived through registration of MPC images to a static model and those derived through integration of the CPC velocity data. The accuracy ranged from 0.47 mm to 0.77 mm for the patella and femur and from 0.68 mm to 0.86 mm for the patellofemoral joint. For purely quantifying joint kinematics, CPC remains an analytically simpler and more accurate (accuracy <0.33 mm) technique. However, for application requiring the tracking of an entire surface, such as quantifying cartilage contact kinematics, this combined imaging approach produces accurate results with minimal operator intervention. Published by Elsevier Ltd.

  11. Combination of dry dark fermentation and mechanical pretreatment for lignocellulosic deconstruction: An innovative strategy for biofuels and volatile fatty acids recovery

    International Nuclear Information System (INIS)

    Motte, Jean-Charles; Sambusiti, Cecilia; Dumas, Claire; Barakat, Abdellatif

    2015-01-01

    Highlights: • A novel combination of solid-state fermentation and fine milling was developed. • Biological pretreatment produces valuable bioproducts (VFA and biohydrogen). • Solid-state dark fermentation improves considerably the milling efficiency. • Bioethanol yield was higher after a strong particle size reduction. • Substrate conversion was two times higher than conventional processes. - Abstract: In the present study, the feasibility of combining dry dark fermentation and mechanical pretreatment of wheat straw was studied in order to improve substrate valorization, save energy input, decrease the environmental impact and diversify biofuels and volatile fatty acids production. To this end, dark fermentation of wheat straw was performed at 55 °C and 35 °C under solid-state conditions (23% of total solid content) and it was considered as a biological pretreatment. Both biologically treated and raw straws were reduced at four particles size to cover the range of fine (50 < X < 500 μm) and ultrafine milling (<50 μm). Biological pretreatment led to a substrate conversion of 16% and 14%, mainly into volatile fatty acids and biohydrogen. Biological pretreatment improved the substrate grindability with a reduction of mean particle size up to 31% and a reduction of the milling specific energy consumption up to 35% compared to untreated straw. Finally, related to untreated straw, this combination of biological and mechanical treatments improved the bioethanol yield up to 83%, which leads to an enhancement of the overall substrate conversion up to 131%. Based on these high yields, this combination of dry biological–mechanical pretreatments appears more attractive and efficient in terms of bioproducts production, energy efficiency and environmental impact, compared to conventional pretreatments

  12. Technology Innovation and Future Research Needs in Net Shape Manufacturing

    International Nuclear Information System (INIS)

    Yang, Dong-Yol

    2005-01-01

    The rapid change in customer needs and industrial environment has demanded innovations in the manufacturing sector. Metal forming industries have been confronted with new challenges of innovations in products, processes, machines, materials and production systems. From the viewpoints of competitiveness of products, new paradigms are required for innovation in manufacturing, especially in net shape manufacturing. Product innovations are increasingly put under emphasis beyond manufacturing innovations based on the holistic concurrent engineering approach. The presentation covers not only the innovation methodologies, but also the innovation directions in net shape manufacturing

  13. Open innovation

    DEFF Research Database (Denmark)

    West, Joel; Bogers, Marcel

    2017-01-01

    Interest in open innovation (OI) as a field of research has grown exponentially since the phrase was coined by Chesbrough in his 2003 book, with numerous articles, special issues, books, and conference sessions. Various reviews of the literature have summarized prior work, offered new frameworks......, and identified opportunities for future research. Here we summarize these opportunities, which include more research on outbound OI, the role of open innovation in services, and network forms of collaboration such as consortia, communities, ecosystems, and platforms. Research should also examine the use of OI...... by small, new, and not-for-profit organizations, as well as the linkage of individual actions and motivations to open innovation. Other opportunities include better measuring the costs, benefits, antecedents, mediators and moderators of the effects of OI on performance, and understanding why and how OI...

  14. Reconsidering Innovation

    DEFF Research Database (Denmark)

    Vaaben, Nana Katrine

    Innovation og reformer er på dagsordenen allevegne, ikke mindst i politiske forsøg på at reorganisere den offentlige sektor for at få velfærdssamfundet til at kunne overleve økonomisk tumult og dystre fremtidsprognoser. Dette papir undersøger, hvordan klassiske antropologiske teorier og debatter om...... forandring og myter kan hjælpe os med at genoverveje teoretiske forståelser af innovation i organisatoriske studier. I særlig grad sættes der fokus på de implikationer som vores "innovationsmyte" kan have for offentligt ansatte og værdsættelsen af deres arbejde. Analysens argument er, at innovation ikke skal...

  15. Industrialized Innovation: The Connection of Science & Technology Innovation with Industrial Innovation

    Institute of Scientific and Technical Information of China (English)

    Yinxing Hong; Yao Lu; Jianghuai Zheng

    2017-01-01

    In light of the relationship and the current disconnection between science & technology (S&T) innovation and industrial innovation in China,it is necessary to put forward and emphasize the concept of industrialized innovation.Industrialized innovation is the bridge and intermediation between S&T innovation and industrial innovation,which is not only a concept,but also a mechanism and combination force.There are two ways to achieve industrialized innovation:through industry-university-research coordination and through technology entrepreneurship.The meaning of industry-university-research coordination is not about coordination among industry,university and research sectors in an institutional sense;rather it is about the coordination of the functions of cultivation and development in new industries,new technologies,and new talents of industrialized innovation.The incentive mechanism for industrialized innovation should motivate not only innovation but also coordination.Technology entrepreneurship is the industrialization of new technology through business start-ups,which occurs beyond the stage of incubation and development of new technology.The capital of technology entrepreneurship is the set consisting of knowledge capital manifested through technological innovation,human capital manifested through entrepreneurs,and physical capital in the form of venture capital.While physical capital is indispensable,knowledge capital and human capital play the decisive role in technology entrepreneurship.The industrialization of technological innovation involves two requirements:one is to enable the new technology industry to achieve a large scale rapidly,and the other is to fully realize the potential value of the new technology.Both requirements are reliant on effective innovation in business models.

  16. Innovation Assessment

    DEFF Research Database (Denmark)

    Hasselbalch, Jacob

    2017-01-01

    Current regulatory approaches are ill-equipped to address the challenges of governing through periods of disruptive technological change. This article hones in on the use of assessment regimes at the level of the European Union, particularly in the work of the Commission, to argue for a missing...... I label innovation assessment, to steer polities through periods of disruptive technological change, during which innovations have taken concrete forms and are beginning to diffuse, but still exhibit much scope for rapid, unexpected change and alternative trajectories of development. By juxtaposing...

  17. On methodology

    DEFF Research Database (Denmark)

    Cheesman, Robin; Faraone, Roque

    2002-01-01

    This is an English version of the methodology chapter in the authors' book "El caso Berríos: Estudio sobre información errónea, desinformación y manipulación de la opinión pública".......This is an English version of the methodology chapter in the authors' book "El caso Berríos: Estudio sobre información errónea, desinformación y manipulación de la opinión pública"....

  18. Comparative analysis of in vivo T cell depletion with radiotherapy, combination chemotherapy, and the monoclonal antibody Campath-1G, using limiting dilution methodology

    International Nuclear Information System (INIS)

    Theobald, M.; Hoffmann, T.; Bunjes, D.; Heit, W.

    1990-01-01

    We have investigated the efficacy of standard conditioning regimens for bone marrow transplantation in depleting functional T lymphocytes in vivo and have compared it with the efficacy of the monoclonal antibody Campath-1G. Using limiting dilution techniques the frequencies of proliferating T cell precursors (PTL), cytotoxic T cell precursors (CTL-p), helper T cell precursors (HTL-p), and mature helper T cells (HTL) were determined before and after treatment. Both total body irradiation and combination chemotherapy with busulfan/cyclophosphamide were highly efficient at depleting PTL, CTL-p, and HTL-p (0-4 days) but spared HTL to a variable extent (0-99.5%). In the majority of patients treated with Campath-1G a similar degree of PTL, CTL-p, and HTL-p depletion was achieved, and, in addition, HTL were effectively removed (greater than 95.5%). These results suggest that Campath-1G could be successfully employed in depleting radio- and chemotherapy-resistant host T lymphocytes prior to T-depleted bone marrow transplantation

  19. Lichens biomonitoring as feasible methodology to assess air pollution in natural ecosystems: combined study of quantitative PAHs analyses and lichen biodiversity in the Pyrenees Mountains.

    Science.gov (United States)

    Blasco, María; Domeño, Celia; Nerín, Cristina

    2008-06-01

    The air quality in the Aragón valley, in the central Pyrenees, has been assessed by evaluation of lichen biodiversity and mapped by elaboration of the Index of Air Purity (IAP) based on observations of the presence and abundance of eight kinds of lichen with different sensitivity to air pollution. The IAP values obtained have been compared with quantitative analytical measures of 16 PAHs in the lichen Evernia prunastri, because this species was associated with a wide range of traffic exposure and levels of urbanization. Analyses of PAHs were carried out by the DSASE method followed by an SPE clean-up step and GC-MS analysis. The concentration of total PAHs found in lichen samples from the Aragón valley ranged from 692 to 6420 ng g(-1) and the PAHs profile showed predominance of compounds with three aromatic rings. The influence of the road traffic in the area has been shown because values over the median concentration of PAHs (>1092 ng g(-1)), percentage of combustion PAHs (>50%), and equivalent toxicity (>169) were found in lichens collected at places exposed to the influence of traffic. The combination of both methods suggests IAP as a general method for evaluating the air pollution referenced to PAHs because it can be correlated with the content of combustion PAHs and poor lichen biodiversity can be partly explained by the air pollution caused by specific PAHs.

  20. An Innovative Approach to Treat Incisors Hypomineralization (MIH): A Combined Use of Casein Phosphopeptide-Amorphous Calcium Phosphate and Hydrogen Peroxide-A Case Report.

    Science.gov (United States)

    Mastroberardino, Stefano; Campus, Guglielmo; Strohmenger, Laura; Villa, Alessandro; Cagetti, Maria Grazia

    2012-01-01

    Molar Incisor Hypomineralization (MIH) is characterized by a developmentally derived deficiency in mineral enamel. Affected teeth present demarcated enamel opacities, ranging from white to brown; also hypoplasia can be associated. Patient frequently claims aesthetic discomfort if anterior teeth are involved. This problem leads patients to request a bleaching treatment to improve aestheticconditions.Nevertheless, hydrogen peroxide can produce serious side-effects, resulting from further mineral loss. Microabrasion and/or a composite restoration are the treatments of choice in teeth with mild/moderate MIH, but they also need enamel loss. Recently, a new remineralizing agent based on Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) has been proposed to be effective in hypomineralized enamel, improving also aesthetic conditions. The present paper presents a case report of a young man with white opacities on incisors treated with a combined use of CPP-ACP mousse and hydrogen peroxide gel to correct the aesthetic defect. The patient was instructed to use CPP-ACP for two hours per day for three months in order to obtain enamel remineralization followed by a combined use of CPP-ACP and bleaching agent for further two months. At the end of this five-month treatment, a noticeable aesthetic improvement of the opacities was observed.

  1. An Innovative Approach to Treat Incisors Hypomineralization (MIH: A Combined Use of Casein Phosphopeptide-Amorphous Calcium Phosphate and Hydrogen Peroxide—A Case Report

    Directory of Open Access Journals (Sweden)

    Stefano Mastroberardino

    2012-01-01

    Full Text Available Molar Incisor Hypomineralization (MIH is characterized by a developmentally derived deficiency in mineral enamel. Affected teeth present demarcated enamel opacities, ranging from white to brown; also hypoplasia can be associated. Patient frequently claims aesthetic discomfort if anterior teeth are involved. This problem leads patients to request a bleaching treatment to improve aestheticconditions.Nevertheless, hydrogen peroxide can produce serious side-effects, resulting from further mineral loss. Microabrasion and/or a composite restoration are the treatments of choice in teeth with mild/moderate MIH, but they also need enamel loss. Recently, a new remineralizing agent based on Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP has been proposed to be effective in hypomineralized enamel, improving also aesthetic conditions. The present paper presents a case report of a young man with white opacities on incisors treated with a combined use of CPP-ACP mousse and hydrogen peroxide gel to correct the aesthetic defect. The patient was instructed to use CPP-ACP for two hours per day for three months in order to obtain enamel remineralization followed by a combined use of CPP-ACP and bleaching agent for further two months. At the end of this five-month treatment, a noticeable aesthetic improvement of the opacities was observed.

  2. Regional Shelter Analysis Methodology

    Energy Technology Data Exchange (ETDEWEB)

    Dillon, Michael B. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dennison, Deborah [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kane, Jave [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Walker, Hoyt [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Miller, Paul [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-08-01

    The fallout from a nuclear explosion has the potential to injure or kill 100,000 or more people through exposure to external gamma (fallout) radiation. Existing buildings can reduce radiation exposure by placing material between fallout particles and exposed people. Lawrence Livermore National Laboratory was tasked with developing an operationally feasible methodology that could improve fallout casualty estimates. The methodology, called a Regional Shelter Analysis, combines the fallout protection that existing buildings provide civilian populations with the distribution of people in various locations. The Regional Shelter Analysis method allows the consideration of (a) multiple building types and locations within buildings, (b) country specific estimates, (c) population posture (e.g., unwarned vs. minimally warned), and (d) the time of day (e.g., night vs. day). The protection estimates can be combined with fallout predictions (or measurements) to (a) provide a more accurate assessment of exposure and injury and (b) evaluate the effectiveness of various casualty mitigation strategies. This report describes the Regional Shelter Analysis methodology, highlights key operational aspects (including demonstrating that the methodology is compatible with current tools), illustrates how to implement the methodology, and provides suggestions for future work.

  3. Multisensory innovation

    DEFF Research Database (Denmark)

    Brem, Alexander; Kampfer, Kristina; Ivens, Bjoern

    2017-01-01

    For many companies, differentiating their offerings from competitors' value propositions is becoming increasingly challenging. In order to formulate convincing value propositions, a holistic approach is required that takes human perception and sensation into consideration. This article assesses t...... and ultimately alters behavior and thus substantiates its role in multisensory innovation and product design....

  4. Innovations (INNO)

    International Nuclear Information System (INIS)

    1978-01-01

    The annual report of the working group on innovations (INNO) deals with the projects carried out by the participating institutes and laboratories in the two fields of 1) application of non-nuclear methods and 2) non-nuclear research and development. (HK) [de

  5. Effektiv innovation

    DEFF Research Database (Denmark)

    Søndergaard, Katia Dupret; Brandi, Ulrik

    2011-01-01

    Er det vækst og udvikling eller åbenhed, videnudvikling, netværk, leg og innovation? Eller er det prisregulering, tilpasning og stærk styring, som skal gøre universiteterne til førende drivkræfter for dansk vækst?...

  6. Software Innovation

    DEFF Research Database (Denmark)

    Rose, Jeremy

      Innovation is the forgotten key to modern systems development - the element that defines the enterprising engineer, the thriving software firm and the cutting edge software application.  Traditional forms of technical education pay little attention to creativity - often encouraging overly...

  7. PECULIARITIES OF ASSESSMENT AND RISK MANAGEMENT IN INNOVATIVE PROJECTS

    Directory of Open Access Journals (Sweden)

    Victor V. Guzhov

    2014-01-01

    Full Text Available The methodological and methodicalbases of risk management in innovativeprojects. Classification of risks. Types of risks depending on the stage of realizationof the innovative project. Investigated thefactors contributing to the emergence ofrisk situations. The basic techniques of risk management of innovation projects.Proposed criteria for the choice of the innovative project to implement in the realsector of the economy.

  8. Multi-indication and Combination Pricing and Reimbursement of Pharmaceuticals: Opportunities for Improved Health Care through Faster Uptake of New Innovations.

    Science.gov (United States)

    Persson, Ulf; Norlin, J M

    2018-04-01

    Many pharmaceuticals are effective in multiple indications and the degree of effectiveness may differ. A product-based pricing and reimbursement system with a single price per product is insufficient to reflect the variable values between different indications. The objective of this article is to present examples of actual pricing and reimbursement decisions using current value-based pricing in Sweden and to discuss their implications and possible solutions. The value of several cancer drugs was estimated for various indications based on a willingness-to-pay threshold of 1 million SEK (EUR 104,000) per QALY gained. For some drugs, the estimated value was higher than the drug acquisition cost in several indications, whilst in others, the estimated value was lower than the drug acquisition cost. Drugs used in combination present a special case. If a drug prolongs survival and consequently also a continued use of the anchor drug, the combination use may not be cost effective even at a zero price. In a product-based pricing and reimbursement system, patients may not get access to drugs or access may be delayed and manufacturers may be discouraged to invest in future indications. To overcome these issues, there are several approaches to link price and value. One approach is a "weighted-average" price based on an average of the value across all indications. Another is "multi-indication pricing," which enables price differentiation between indications. However, there are several barriers for applying multi-indication pricing and reimbursement schemes. One barrier is the lack of existing administrative infrastructure to track patients' indications.

  9. Problems of regional innovation strategy forming

    Directory of Open Access Journals (Sweden)

    I. M. Golova

    2010-09-01

    Full Text Available The author considered problems and contradictions of modern innovation policy in Russia. It is shown, that at present time regions are removed from management of science-technical complex and spatial priorities are not produced. It is a serious factor of risk for conservation perspectives of innovation development for Russia. With taking into account of world experience main districts of rise effects regional police were formulated. It is underlined, that creation conditions for transformation of regional authorities in active subjects of innovation policy is necessary condition for building vital innovation system. It is shown, that state innovation policy must be constructed at combination of next principles: a support science-technical potential of regions — generators of innovation and creation conditions for its realization; b using of innovations for evening-out disproportions of social-economic development between regions; c widening powers and financial possibilities of regions at management of innovation climate. Methodical approaches for making effective mechanisms of management of innovation processes of territory are opened. Typology of Russian regions with high and middle degree of innovation climate is proposed, which takes level of science and innovation potential of territory and also degree of comfort of social-economic conditions for development of innovation activity are offered. Peculiarities of innovation strategy for different types of regions are defined. This typology may be used for substantiation spatial priorities of innovation strategy of Russia.

  10. Balanced Innovation Management

    National Research Council Canada - National Science Library

    King, David R

    2007-01-01

    The Department of Defense has demonstrated success in managing innovation. The military's approach to innovation management extends beyond traditional distinctions between internal and external innovation modes...

  11. Application of IT-technologies in visualization of innovation project life-cycle stages during the study of the course "Management of innovation projects"

    Science.gov (United States)

    Kolychev, V. D.; Prokhorov, I. V.

    2017-01-01

    The article presents a methodology for the application of IT-technologies in teaching discipline "Management of innovation projects," which helps students to be more competitive and gather the useful skills for their future specialization in high-tech areas. IT-technologies are widely used nowadays in educational and training spheres especially in knowledge-intensive disciplines such as systems analysis, the theory of games, operations research, theory of risks, innovation management etc. For studying such courses it is necessary to combine both mathematical models and information technology approaches for the clear understanding of the investigated object. That is why this article comprises both the framework of research and the IT-tools for investigation in the educational process. Taking into consideration the importance of the IT-system implementation especially for the university we assume to suggest the methods of research in the area of innovation projects with the help of IT-support.

  12. Social Dynamics of Participatory Innovation

    DEFF Research Database (Denmark)

    Sproedt, Henrik

    2011-01-01

    perspective on innovation. Then, a similar development in the field of knowledge and knowing is presented, where the perspective changes from a divisional systemthinking towards a more relational view of complementing combinations of knowledge and knowing, recognizing the challenge of boundaries. Further......A conceptual framework for a coherent understanding of knowledge as a socially constructed resource in flux over boundaries when innovating with others is constructed. Starting with an overview of different perspectives on innovation, showing a development towards a more iterative social process......, relating, cognitive social capital and the justification of knowledge are described as different but interdependent dimensions of transforming knowledge across boundaries in participatory innovation. A multi-level concept of social dynamics of participatory innovation is proposed, and a model...

  13. Complexities in innovation management in companies from the European industry. A path model of innovation project performance determinants

    NARCIS (Netherlands)

    Tepic, M.; Kemp, R.G.M.; Omta, S.W.F.; Fortuin, F.T.J.M.

    2013-01-01

    Purpose – The purpose of this paper is to provide an integrated framework of complex relations among innovation characteristics, organizational capabilities, innovation potential and innovation performance. Design/methodology/approach – The model is tested using partial least squares (PLS) modeling

  14. Managing Innovation In View Of The Uncertainties

    Directory of Open Access Journals (Sweden)

    Anton Igorevich Mosalev

    2012-12-01

    Full Text Available Study of the problems of uncertainty in innovation is at present the most up to date. Approaches to its definition, arranged primarily on the assumption and include the known parameters, which essentially is a game approach to the assessment. Address specific issues of governance of innovation in accounting uncertainty still remains open and the most relevant, especially when the innovation represented by one of the drivers of growth of national economies. This paper presents a methodological approach to determining the degree of uncertainty and an approach to the management of innovation through a system of mathematical modeling on the criterion of gross errors.

  15. Social innovation education: towards a framework for learning design

    OpenAIRE

    Alden Rivers, Bethany; Armellini, Alejandro; Maxwell, Rachel; Allen, Sue; Durkin, Chris

    2015-01-01

    Purpose—This paper proposes a theoretical framework to support the embedding of social innovation education in existing academic programmes.\\ud Design/methodology/approach—By adopting Conole et al.’s (2004) methodological approach to reviewing, mapping and modelling learning theory, this study addresses four research questions: 1) How can social innovation education be defined? 2) Which learning theories best support social innovation education? 3) How do such learning theories relate to exis...

  16. Methodological guidelines

    International Nuclear Information System (INIS)

    Halsnaes, K.; Callaway, J.M.; Meyer, H.J.

    1999-01-01

    The guideline document establishes a general overview of the main components of climate change mitigation assessment. This includes an outline of key economic concepts, scenario structure, common assumptions, modelling tools and country study assumptions. The guidelines are supported by Handbook Reports that contain more detailed specifications of calculation standards, input assumptions and available tools. The major objectives of the project have been provided a methodology, an implementing framework and a reporting system which countries can follow in meeting their future reporting obligations under the FCCC and for GEF enabling activities. The project builds upon the methodology development and application in the UNEP National Abatement Coasting Studies (UNEP, 1994a). The various elements provide countries with a road map for conducting climate change mitigation studies and submitting national reports as required by the FCCC. (au) 121 refs

  17. Methodological guidelines

    Energy Technology Data Exchange (ETDEWEB)

    Halsnaes, K.; Callaway, J.M.; Meyer, H.J.

    1999-04-01

    The guideline document establishes a general overview of the main components of climate change mitigation assessment. This includes an outline of key economic concepts, scenario structure, common assumptions, modelling tools and country study assumptions. The guidelines are supported by Handbook Reports that contain more detailed specifications of calculation standards, input assumptions and available tools. The major objectives of the project have been provided a methodology, an implementing framework and a reporting system which countries can follow in meeting their future reporting obligations under the FCCC and for GEF enabling activities. The project builds upon the methodology development and application in the UNEP National Abatement Coasting Studies (UNEP, 1994a). The various elements provide countries with a road map for conducting climate change mitigation studies and submitting national reports as required by the FCCC. (au) 121 refs.

  18. Analysis of human error in occupational accidents in the power plant industries using combining innovative FTA and meta-heuristic algorithms

    Directory of Open Access Journals (Sweden)

    M. Omidvari

    2015-09-01

    Full Text Available Introduction: Occupational accidents are of the main issues in industries. It is necessary to identify the main root causes of accidents for their control. Several models have been proposed for determining the accidents root causes. FTA is one of the most widely used models which could graphically establish the root causes of accidents. The non-linear function is one of the main challenges in FTA compliance and in order to obtain the exact number, the meta-heuristic algorithms can be used. Material and Method: The present research was done in power plant industries in construction phase. In this study, a pattern for the analysis of human error in work-related accidents was provided by combination of neural network algorithms and FTA analytical model. Finally, using this pattern, the potential rate of all causes was determined. Result: The results showed that training, age, and non-compliance with safety principals in the workplace were the most important factors influencing human error in the occupational accident. Conclusion: According to the obtained results, it can be concluded that human errors can be greatly reduced by training, right choice of workers with regard to the type of occupations, and provision of appropriate safety conditions in the work place.

  19. Innovative measures to combat rare diseases in China: The national rare diseases registry system, larger-scale clinical cohort studies, and studies in combination with precision medicine research.

    Science.gov (United States)

    Song, Peipei; He, Jiangjiang; Li, Fen; Jin, Chunlin

    2017-02-01

    China is facing the great challenge of treating the world's largest rare disease population, an estimated 16 million patients with rare diseases. One effort offering promise has been a pilot national project that was launched in 2013 and that focused on 20 representative rare diseases. Another government-supported special research program on rare diseases - the "Rare Diseases Clinical Cohort Study" - was launched in December 2016. According to the plan for this research project, the unified National Rare Diseases Registry System of China will be established as of 2020, and a large-scale cohort study will be conducted from 2016 to 2020. The project plans to develop 109 technical standards, to establish and improve 2 national databases of rare diseases - a multi-center clinical database and a biological sample library, and to conduct studies on more than 50,000 registered cases of 50 different rare diseases. More importantly, this study will be combined with the concept of precision medicine. Chinese population-specific basic information on rare diseases, clinical information, and genomic information will be integrated to create a comprehensive predictive model with a follow-up database system and a model to evaluate prognosis. This will provide the evidence for accurate classification, diagnosis, treatment, and estimation of prognosis for rare diseases in China. Numerous challenges including data standardization, protecting patient privacy, big data processing, and interpretation of genetic information still need to be overcome, but research prospects offer great promise.

  20. Innovative Strategy in Treating Angina Pectoris with Chinese Patent Medicines by Promoting Blood Circulation and Removing Blood Stasis: Experience from Combination Therapy in Chinese Medicine.

    Science.gov (United States)

    Xiong, Xing-Jiang; Wang, Zhong; Wang, Jie

    2015-01-01

    Coronary heart disease (CHD) is one of the leading causes of death worldwide. Moreover, angina pectoris is one of the most important types of CHD. Therefore, prevention and effective treatment of angina pectoris is of utmost importance in both China and western countries. However, undesirable effects of antianginal therapy do influence treatment adherence to a certain extent. Therefore, it's not surprising that, complementary and alternative medicine (CAM), including Chinese medicine (CM), are widely welcomed among patients with CHD, hoping that it might complement western medicine. In our previous studies, blood stasis syndrome (BSS) (Xueyu Zheng) was the main syndrome (Zheng-hou) of angina pectoris. Currently, China Food and Drug Administration authoritatively recommended more than 200 Chinese patent medicines (CPMs) as complementary or adjunctive therapies for symptom management and enhancing quality of life along with mainstream care on angina pectoris management in mainland China. This paper reviewed 4 kinds of most frequently-used CPMs by promoting blood circulation and removing blood stasis in the treatment of angina pectoris. It aims to evaluate the current evidence of CPMs in combination therapy for angina pectoris. This review indicated that CPMs as adjunctive treatment to routine antianginal therapy play an active role in reducing the incidence of primary endpoint events, decreasing anginal attack rate, and improving electrocardiogram. Additionally, CPMs have been proven relatively safe. Further rigorously designed clinical trials should be conducted to confirm the results.

  1. Sustainable livestock production: Low emission farm – The innovative combination of nutrient, emission and waste management with special emphasis on Chinese pig production

    Directory of Open Access Journals (Sweden)

    Thomas Kaufmann

    2015-09-01

    Full Text Available Global livestock production is going to be more and more sophisticated in order to improve efficiency needed to supply the rising demand for animal protein of a growing, more urban and affluent population. To cope with the rising public importance of sustainability is a big challenge for all animal farmers and more industrialized operations especially. Confined animal farming operations (CAFO are seen very critical by many consumers with regard to their sustainability performance, however, the need to improve the sustainability performance especially in the ecological and social dimension exists at both ends of the intensity, i.e., also for the small holder and family owned animal farming models. As in livestock operations, feed and manure contribute the majority to the three most critical environmental impact categories global warming potential (GWP, acidification (AP and eutrophication potential (EP any effort for improvement should start there. Intelligent combination of nutrient-, emission- and waste management in an integrated low emission farm (LEF concept not only significantly reduces the environmental footprint in the ecological dimension of sustainability, but by producing renewable energy (heat, electricity, biomethane with animal manure as major feedstock in an anaerobic digester also the economic dimension can be improved. Model calculations using new software show the ecological improvement potential of low protein diets using more supplemented amino acids for the Chinese pig production. The ecological impact of producing biogas or upgraded biomethane, of further treatment of the digestate and producing defined fertilizers is discussed. Finally, the LEF concept allows the integration of an insect protein plant module which offers additional ecological and economical sustainability improvement potential in the future. Active stakeholder communication about implementation steps of LEF examples improves also the social aspect of

  2. Tunable hydrogel composite with two-step processing in combination with innovative hardware upgrade for cell-based three-dimensional bioprinting.

    Science.gov (United States)

    Wüst, Silke; Godla, Marie E; Müller, Ralph; Hofmann, Sandra

    2014-02-01

    Three-dimensional (3-D) bioprinting is the layer-by-layer deposition of biological material with the aim of achieving stable 3-D constructs for application in tissue engineering. It is a powerful tool for the spatially directed placement of multiple materials and/or cells within the 3-D sample. Encapsulated cells are protected by the bioink during the printing process. Very few materials are available that fulfill requirements for bioprinting as well as provide adequate properties for cell encapsulation during and after the printing process. A hydrogel composite including alginate and gelatin precursors was tuned with different concentrations of hydroxyapatite (HA) and characterized in terms of rheology, swelling behavior and mechanical properties to assess the versatility of the system. Instantaneous as well as long-term structural integrity of the printed hydrogel was achieved with a two-step mechanism combining the thermosensitive properties of gelatin with chemical crosslinking of alginate. Novel syringe tip heaters were developed for improved temperature control of the bioink to avoid clogging. Human mesenchymal stem cells mixed into the hydrogel precursor survived the printing process and showed high cell viability of 85% living cells after 3 days of subsequent in vitro culture. HA enabled the visualization of the printed structures with micro-computed tomography. The inclusion of HA also favors the use of the bioink for bone tissue engineering applications. By adding factors other than HA, the composite could be used as a bioink for applications in drug delivery, microsphere deposition or soft tissue engineering. Copyright © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  3. Development of an Innovative Intradermal siRNA Delivery System Using a Combination of a Functional Stearylated Cytoplasm-Responsive Peptide and a Tight Junction-Opening Peptide

    Directory of Open Access Journals (Sweden)

    Hisako Ibaraki

    2016-09-01

    Full Text Available As a new category of therapeutics for skin diseases including atopic dermatitis (AD, nucleic acids are gaining importance in the clinical setting. Intradermal administration is noninvasive and improves patients′ quality of life. However, intradermal small interfering RNA (siRNA delivery is difficult because of two barriers encountered in the skin: intercellular lipids in the stratum corneum and tight junctions in the stratum granulosum. Tight junctions are the major barrier in AD; therefore, we focused on functional peptides to devise an intradermal siRNA delivery system for topical skin application. In this study, we examined intradermal siRNA permeability in the tape-stripped (20 times back skin of mice or AD-like skin of auricles treated with 6-carboxyfluorescein-aminohexyl phosphoramidite (FAM-labeled siRNA, the tight junction modulator AT1002, and the functional cytoplasm-responsive stearylated peptide STR-CH2R4H2C by using confocal laser microscopy. We found that strong fluorescence was observed deep and wide in the epidermis and dermis of back skin and AD-like ears after siRNA with STR-CH2R4H2C and AT1002 treatment. After 10 h from administration, brightness of FAM-siRNA was significantly higher for STR-CH2R4H2C + AT1002, compared to other groups. In addition, we confirmed the nontoxicity of STR-CH2R4H2C as a siRNA carrier using PAM212 cells. Thus, our results demonstrate the applicability of the combination of STR-CH2R4H2C and AT1002 for effective intradermal siRNA delivery.

  4. The differentiated impacts of organizational innovation practices on technological innovation persistence

    OpenAIRE

    Le Bas , Christian; Mothe , Caroline; Nguyen-Thi , Thuc Uyen

    2015-01-01

    International audience; Purpose – The purpose of this paper is to test the major determinants of technological (product and process) innovation persistence and provides evidence of the significant role of organizational innovation. Design/methodology/approach – Data came from two waves of the Luxembourg Community Innovation Survey (CIS): CIS2006 for 2004-2006 and CIS2008 for 2006-2008. The longitudinal data set resulted in a final sample of 287 firms. A multinomial probit model estimates the ...

  5. Directed Innovation of Business Models

    OpenAIRE

    Stelian Brad; Emilia Brad

    2016-01-01

    Business model innovation is an important issue to keep business competitive and increase company’s profits. Due to many market attractors, identification of appropriate paths of business model evolution is a painful and risky process. To improve decision’s effectiveness in this process, an architectural construct of analysis and conceptualization for business model innovation that combines directed evolution and blue ocean concepts is proposed in this paper under the name o...

  6. Assessment of Innovation and Performance in the Fruit Chain; The Innovation-Performance Matrix

    NARCIS (Netherlands)

    Trienekens, J.H.; Uffelen, van R.L.M.; Debaire, J.; Omta, S.W.F.

    2008-01-01

    Purpose - This paper aims to bridge the concepts of innovation and performance and to develop a framework to assess innovation and performance in food chains. Design/methodology/approach - Based on an extensive literature search the paper identifies critical success factors (CSFs) and related

  7. Managing innovation

    International Nuclear Information System (INIS)

    Vanston, J.H.

    1988-01-01

    The author addresses the skepticism about high Tc applications. According to the analysis presented, superconductivity research is following a standard model for technological break throughs. This model, which describe the innovation process from theory through widespread adoption, is presented and superconductivity's place therein is discussed. Business opportunities in superconductivity are described and the competition between the U.S. and Japan in the development of the high T c applications is addressed

  8. STIMULATING INNOVATIONS AND PERFORMANCE OF COMPANIES IN BOSNIA AND HERZEGOVINA

    Directory of Open Access Journals (Sweden)

    Andrijana Ostojić Mihić

    2016-12-01

    Full Text Available The paper explores the perception of innovations and importance of innovativeness, determines innovation potential and links the application of innovations in companies to the material stimulation of employees. The aim of the paper is to provide information on encouraging and developing the culture of innovations and on strengthening the awareness of the importance of material motivation for the creation of innovations. The paper presents an overview of the existing findings on the company’s innovation potential and the possibility to encourage innovations by means of the selected tools and techniques of human resource management. The contribution of the paper is based on the empirical research of a representative sample of 250 medium-size and large companies in Bosnia and Herzegovina (BiH using the methodology of the Croatian Coefficient of Innovativeness (HKI, whereby special attention is given to the observation of the possible link between stimulating employees to innovate and accomplishing the company’s selected performance.

  9. METODOLOGÍA PARA LA MEDICIÓN DE INNOVACIONES TECNOLÓGICAS APLICADAS A EMPRESAS DEL SECTOR AGROINDUSTRIAL METHODOLOGY TO MEASURE TECHNOLOGICAL INNOVATION APPLIED TO COMPANIES FROM AGROINDUSTRIAL SECTOR

    Directory of Open Access Journals (Sweden)

    JHON WILDER ZARTHA SOSSA

    2009-12-01

    Full Text Available El proyecto contempló en una forma preliminar, el análisis de los indicadores de innovación de empresas del sector de elaboración de productos alimenticios*, según la encuesta del DANE [1] en donde se clasifican las empresas por su grado de innovación. Posteriormente se analizaron los fundamentos matemáticos de la difusión de la innovación tecnológica en tres empresas del sector agroindustrial de Colombia, así como las variables involucradas en este fenómeno; para ello se estudiaron los parámetros de desempeño, ventas y producción en el tiempo, los cuales presentan un comportamiento de curvas en "S" o curva logística con el fin de poder analizar los puntos de inflexión y otros parámetros de innovaciones tecnológicas a través de correlaciones matemáticas. Para analizar las curvas en "S" se tomaron varios modelos matemáticos de distribución logística y luego de encontrar el que se ajustó a los datos de las empresas se procedió a realizar la correlación empleando el software Statgraphics; con esta herramienta se encontraron los valores de las constantes que existen en el modelo. Con las curvas generadas por los datos obtenidos en el sector agroindustrial, con series de tiempos entre uno y cinco años y con los valores de las constantes se analizaron los puntos de inflexión, parámetros de crecimiento y las asíntotas de cada una de las curvas en "S" propuestas, y se generaron conclusiones relacionadas con ciclos de innovación, estrategia de mercadeo, tiempos para la protección de innovaciones y otros parámetros de desempeño que son útiles para las empresas del sector.This project looked at, in a preliminary phase, the innovation indicators analysis for companies from food manufacturing sector according to the survey by DANE in this survey the companies are classified according its innovation level. After that, the mathematical foundations of the technological innovation diffusion were analyzed in three companies

  10. Innovations in urban agriculture

    NARCIS (Netherlands)

    Schans, van der J.W.; Renting, Henk; Veenhuizen, Van René

    2014-01-01

    This issuehighlights innovations in urban agriculture. Innovation and the various forms of innovations are of particular importance because urban agriculture is adapted to specific urban challenges and opportunities. Innovation is taking place continuously, exploring the multiple fundions of urban

  11. Innovation and Entrepreneurship | NREL

    Science.gov (United States)

    Innovation and Entrepreneurship Innovation and Entrepreneurship Connect Contact us for more Innovation and Entrepreneurship Center helps connect emerging clean energy businesses with the financial , and pilot opportunities. Read more Events Innovation and entrepreneurship events like the upcoming

  12. Older, sociable capuchins (Cebus capucinus) invent more social behaviors, but younger monkeys innovate more in other contexts

    Science.gov (United States)

    Perry, Susan E.; Godoy, Irene

    2017-01-01

    An important extension to our understanding of evolutionary processes has been the discovery of the roles that individual and social learning play in creating recurring phenotypes on which selection can act. Cultural change occurs chiefly through invention of new behavioral variants combined with social transmission of the novel behaviors to new practitioners. Therefore, understanding what makes some individuals more likely to innovate and/or transmit new behaviors is critical for creating realistic models of culture change. The difficulty in identifying what behaviors qualify as new in wild animal populations has inhibited researchers from understanding the characteristics of behavioral innovations and innovators. Here, we present the findings of a long-term, systematic study of innovation (10 y, 10 groups, and 234 individuals) in wild capuchin monkeys (Cebus capucinus) in Lomas Barbudal, Costa Rica. Our methodology explicitly seeks novel behaviors, requiring their absence during the first 5 y of the study to qualify as novel in the second 5 y of the study. Only about 20% of 187 innovations identified were retained in innovators’ individual behavioral repertoires, and 22% were subsequently seen in other group members. Older, more social monkeys were more likely to invent new forms of social interaction, whereas younger monkeys were more likely to innovate in other behavioral domains (foraging, investigative, and self-directed behaviors). Sex and rank had little effect on innovative tendencies. Relative to apes, capuchins devote more of their innovations repertoire to investigative behaviors and social bonding behaviors and less to foraging and comfort behaviors. PMID:28739946

  13. Innovation patterns in sustainable tourism

    DEFF Research Database (Denmark)

    Hjalager, Anne Mette

    1997-01-01

    to the environment. The following types of innovation can be distinguished: product innovations, classical process innovations, process innovations in information handling, management innovations and institutional innovations. The article concludes that innovations are predominantly launched as part of defensive...

  14. The myths of innovation

    National Research Council Canada - National Science Library

    Berkun, Scott

    2007-01-01

    ... . . . . . . . . . . . . . . . . . . . . . . 1 Chapter 2 We understand the history of innovation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 Chapter 3 There is a method for innovation...

  15. Commercializing government-sponsored innovations: Twelve successful buildings case studies

    Energy Technology Data Exchange (ETDEWEB)

    Brown, M.A.; Berry, L.G.; Goel, R.K.

    1989-01-01

    This report examines the commercialization and use of R and D results funded by DOE's Office of Buildings and Community Systems (OBCS), an office that is dedicated to improving the energy efficiency of the nation's buildings. Three goals guided the research described in this report: to improve understanding of the factors that hinder or facilitate the transfer of OBCS R and D results, to determine which technology transfer strategies are most effective and under what circumstances each is appropriate, and to document the market penetration and energy savings achieved by successfully-commercialized innovations that have received OBCS support. Twelve successfully-commercialized innovations are discussed here. The methodology employed involved a review of the literature, interviews with innovation program managers and industry personnel, and data collection from secondary sources. Six generic technology transfer strategies are also described. Of these, contracting R and D to industrial partners is found to be the most commonly used strategy in our case studies. The market penetration achieved to date by the innovations studied ranges from less than 1% to 100%. For the three innovations with the highest predicted levels of energy savings (i.e., the flame retention head oil burner, low-E windows, and solid-state ballasts), combined cumulative savings by the year 2000 are likely to approach 2 quads. To date the energy savings for these three innovations have been about 0.2 quads. Our case studies illustrate the important role federal agencies can play in commercializing new technologies. 27 refs., 21 figs., 4 tabs.

  16. INNOVATION POTENTIAL OF RUSSIAN NORTHERN REGIONS: DEVELOPMENT TRENDS

    Directory of Open Access Journals (Sweden)

    E.N. Berezikova

    2008-06-01

    Full Text Available In the work for the first time a methodology of complex evaluation of innovation potentials of the regions is proposed. As a result the index of innovation potentials of Russian northern regions was determined, and on its basis all regions are referred to groups corresponding their innovation rating. A system of measures on stimulation of innovation activities in regions has been proposed

  17. MIRD methodology

    International Nuclear Information System (INIS)

    Rojo, Ana M.; Gomez Parada, Ines

    2004-01-01

    The MIRD (Medical Internal Radiation Dose) system was established by the Society of Nuclear Medicine of USA in 1960 to assist the medical community in the estimation of the dose in organs and tissues due to the incorporation of radioactive materials. Since then, 'MIRD Dose Estimate Report' (from the 1 to 12) and 'Pamphlets', of great utility for the dose calculations, were published. The MIRD system was planned essentially for the calculation of doses received by the patients during nuclear medicine diagnostic procedures. The MIRD methodology for the absorbed doses calculations in different tissues is explained

  18. PSA methodology

    Energy Technology Data Exchange (ETDEWEB)

    Magne, L

    1997-12-31

    The purpose of this text is first to ask a certain number of questions on the methods related to PSAs. Notably we will explore the positioning of the French methodological approach - as applied in the EPS 1300{sup 1} and EPS 900{sup 2} PSAs - compared to other approaches (Part One). This reflection leads to more general reflection: what contents, for what PSA? This is why, in Part Two, we will try to offer a framework for definition of the criteria a PSA should satisfy to meet the clearly identified needs. Finally, Part Three will quickly summarize the questions approached in the first two parts, as an introduction to the debate. 15 refs.

  19. PSA methodology

    International Nuclear Information System (INIS)

    Magne, L.

    1996-01-01

    The purpose of this text is first to ask a certain number of questions on the methods related to PSAs. Notably we will explore the positioning of the French methodological approach - as applied in the EPS 1300 1 and EPS 900 2 PSAs - compared to other approaches (Part One). This reflection leads to more general reflection: what contents, for what PSA? This is why, in Part Two, we will try to offer a framework for definition of the criteria a PSA should satisfy to meet the clearly identified needs. Finally, Part Three will quickly summarize the questions approached in the first two parts, as an introduction to the debate. 15 refs

  20. Workplace innovation, social innovation and social quality

    NARCIS (Netherlands)

    Oeij, P.R.A.; Dhondt, S.; Korver, T.

    2011-01-01

    Social innovation is becoming a core value of the EU flagship initiative Innovation Union, but it is not clearly demarcated as it covers a wide field of topics. To understand social innovation within European policymaking a brief outline is given of EC policy developments on innovation and on

  1. Open innovations, innovation communities and firm's innovative activities

    Directory of Open Access Journals (Sweden)

    Getejanc Vesna

    2016-01-01

    Full Text Available The open innovation paradigm emphasizes the fact that firms can improve their performance by opening their business models and reduce their R&D costs by effective incorporation of external knowledge. In other words, companies are able to capture value through knowledge that exists outside the boundaries of their organization. The shift from closed to open model of innovation has imposed the necessity to adopt more open approach to innovation within traditional academic view of business strategy. The adoption of this innovative approach is emphasized even more, by the necessity for stronger connection and cooperation among the participants of the innovation process. Free will and collaboration are the main characteristics of open source software, which is recognized in literature as the role model of open innovation and is a rapidly growing method of technology development. Furthermore, innovative communities represent a great opportunity for improvement of the companies' innovation activities, since they have become an important source for identifying the needs and problems of the users. Their development has been fostered by information technologies and recent social changes in user behavior. Recognizing and better understanding the motivation of the members of the innovation communities that guide them to participate in the process of idea generation, can have significant influence on their incorporation within the innovation process. Equally important is to define the incentives that are suited for stimulating and fostering innovative user activities. Taking this topic in consideration, the purpose of this article is to address the following questions: In what way does the collaboration in open source software projects have positive effect on companies' innovation performance? What are the innovation communities and how can companies establish successful interaction with them? Why does the interaction with innovation communities lead to

  2. THE CONTRIBUTION OF INNOVATION SYSTEMS AND ORGANIZATIONAL CULTURE FOR INNOVATION GENERATION

    Directory of Open Access Journals (Sweden)

    Elaine da Silva

    2018-04-01

    Full Text Available Introduction: Emphasizes the role of innovation in the Information and Knowledge Society as a favorable element of developing regional, national and global levels. Objective: The aim is reflect about the coming of innovation in the context of production systems and their respective role for the development of society. Methodology: The research sets up a qualitative approach to literature and exploratory nature. Results: As from selected literature review, presents conceptual aspects of innovation in the context of production systems and analyzes its contribution to the national innovation system and the role of organizational culture focused on innovation. Conclusions: Think about innovation from the systemic approach, based on the interaction of the different relevant agents to influence and contribute to the generation of innovation is fundamental in the current conjuncture, characterized by the agility of the transformations in social, economic, political and technological contexts.

  3. Innovative instrumentation

    International Nuclear Information System (INIS)

    Anon.

    1983-01-01

    At this year's particle physics conference at Brighton, a parallel session was given over to instrumentation and detector development. While this work is vital to the health of research and its continued progress, its share of prime international conference time is limited. Instrumentation can be innovative three times — first when a new idea is outlined, secondly when it is shown to be feasible, and finally when it becomes productive in a real experiment, amassing useful data rather than operational experience. Hyams' examples showed that it can take a long time for a new idea to filter through these successive stages, if it ever makes it at all

  4. Innovative instrumentation

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1983-11-15

    At this year's particle physics conference at Brighton, a parallel session was given over to instrumentation and detector development. While this work is vital to the health of research and its continued progress, its share of prime international conference time is limited. Instrumentation can be innovative three times — first when a new idea is outlined, secondly when it is shown to be feasible, and finally when it becomes productive in a real experiment, amassing useful data rather than operational experience. Hyams' examples showed that it can take a long time for a new idea to filter through these successive stages, if it ever makes it at all.

  5. Innovations in Biomedical Engineering 2016

    CERN Document Server

    Tkacz, Ewaryst; Paszenda, Zbigniew; Piętka, Ewa

    2017-01-01

    This book presents the proceedings of the “Innovations in Biomedical Engineering IBE’2016” Conference held on October 16–18, 2016 in Poland, discussing recent research on innovations in biomedical engineering. The past decade has seen the dynamic development of more and more sophisticated technologies, including biotechnologies, and more general technologies applied in the area of life sciences. As such the book covers the broadest possible spectrum of subjects related to biomedical engineering innovations. Divided into four parts, it presents state-of-the-art achievements in: • engineering of biomaterials, • modelling and simulations in biomechanics, • informatics in medicine • signal analysis The book helps bridge the gap between technological and methodological engineering achievements on the one hand and clinical requirements in the three major areas diagnosis, therapy and rehabilitation on the other.

  6. Two staged incentive contract focused on efficiency and innovation matching in critical chain project management

    Directory of Open Access Journals (Sweden)

    Min Zhang

    2014-09-01

    Full Text Available Purpose: The purpose of this paper is to define the relative optimal incentive contract to effectively encourage employees to improve work efficiency while actively implementing innovative behavior. Design/methodology/approach: This paper analyzes a two staged incentive contract coordinated with efficiency and innovation in Critical Chain Project Management using learning real options, based on principle-agent theory. The situational experiment is used to analyze the validity of the basic model. Finding: The two staged incentive scheme is more suitable for employees to create and implement learning real options, which will throw themselves into innovation process efficiently in Critical Chain Project Management. We prove that the combination of tolerance for early failure and reward for long-term success is effective in motivating innovation. Research limitations/implications: We do not include the individual characteristics of uncertain perception, which might affect the consistency of external validity. The basic model and the experiment design need to improve. Practical Implications: The project managers should pay closer attention to early innovation behavior and monitoring feedback of competition time in the implementation of Critical Chain Project Management. Originality/value: The central contribution of this paper is the theoretical and experimental analysis of incentive schemes for innovation in Critical Chain Project Management using the principal-agent theory, to encourage the completion of CCPM methods as well as imitative free-riding on the creative ideas of other members in the team.

  7. Approaching Service Innovation Patterns

    OpenAIRE

    Andrea NAGY

    2013-01-01

    The present paper aims at analyzing the types of innovation in the field of services. First, the concept of innovation is defined and second, field literature is reviewed from the perspective of service innovation. The main types of innovation are identified based on several attempts at defining innovation, the most notable being Schumpeter’s. Thus, it is possible to approach concepts such as product and process innovation, incremental and radical innovation. Another aim has been to regard se...

  8. Research in Modeling and Simulation for Airspace Systems Innovation

    Science.gov (United States)

    Ballin, Mark G.; Kimmel, William M.; Welch, Sharon S.

    2007-01-01

    This viewgraph presentation provides an overview of some of the applied research and simulation methodologies at the NASA Langley Research Center that support aerospace systems innovation. Risk assessment methodologies, complex systems design and analysis methodologies, and aer ospace operations simulations are described. Potential areas for future research and collaboration using interactive and distributed simula tions are also proposed.

  9. The Alliance to Scale Digital Innovation and Entrepreneurship (Seed ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The Alliance to Scale Digital Innovation and Entrepreneurship (Seed Alliance). This project will support digital innovations that solve development challenges. ... It combines three regional, competitive small grants and awards programs from ...

  10. Entrepreneurial university: One more door in the intricate innovation maze

    DEFF Research Database (Denmark)

    Jofre, Sergio

    2011-01-01

    Purpose- The purpose of this study is to explore the role of the university in innovation from the perspective of entrepreneurship and innovation systems in order to identify aspects of strategic relevance to the policy and decision-making in the area. The efficacy of innovation systems theory...... as an analytical framework is also discussed. Design/methodology/approach- The role of university in innovation is investigated from the perspective of innovation systems theory, with focus on the Chinese and the Japanese national systems of innovation and triple helix relations. The study builds on a qualitative......) The entrepreneurial university is a consequence rather than a cause in the evolutionary path of innovation systems adapting to their changing environments. (3) The role of university in innovation cannot be fully characterized and explained within the analytical framework of innovation systems. Originality and value...

  11. Destination brands and website evaluation: a research methodology

    Directory of Open Access Journals (Sweden)

    J Fernández-Cavia

    2013-10-01

    Full Text Available Introduction:The World Wide Web has become the primary instrument used by tourists in order to search for information. As a result, tourism websites pertaining to destinations need to be appealing and must convey their brand image in an appropriate, effective manner. However, there is no methodology in place to assess the quality and communicative effectiveness of destination websites that is scientifically sound and universally accepted. The development of such a methodology is one of the tasks we have proposed within the framework of the research project: “New strategies for advertising and promoting Spanish tourism brands online” (CSO2008-02627, funded by the Spanish Ministry of Science and Innovation. Method: The project team have developed an interdisciplinary, all-embracing analysis template combining certain automated analyses with other qualitative and quantitative ones. The template comprises a total of 12 subject areas and 154 indicators prepared on the basis of contributions from prominent experts in each of the fields of work. This article sets out the analysis methodology drawn up and possible applications are given. Results: The primary aim of the project is to provide an assessment methodology that would make it possible to optimise destination brand websites, thus providing a tool to support the work of public tourism destination managers.

  12. User Driven Innovation in the Building Process

    DEFF Research Database (Denmark)

    Christiansson, Per; Sørensen, Kristian Birch; Rødtness, Mette

    2008-01-01

    During the late years there has been an ever-increasing focus on the possibilities to change the building process to raise quality on the final building products as well as the activities of actors involved in the building process. One reason for this interest is the new opportunities evolving du...... building design. A general methodological framework and meta ontology for Virtual Innovation in Construction is presented as well as findings from implementation of the method....... to introduction of advanced information and communication technology (ICT). The paper focuses on creative changes of the building process powered by user driven innovation activities. An overview of existing user driven innovation methodologies is given as well experiences from the ongoing Virtual Innovation...

  13. Toward a dynamic perspective on explorative and exploitative innovation activities: a longitudinal study of innovation in the wind blade industry

    NARCIS (Netherlands)

    de Visser, Matthias

    2010-01-01

    Innovation requires a combination of explorative and exploitative innovation activities. Previous studies have provided valuable insights in the antecedents of investing in explorative and exploitative activities, the structural governance of exploration and exploitation and the performance

  14. Toward a dynamic perspective on explorative and exploitative innovation activities: A longitudinal study of innovation in the wind blade industry

    NARCIS (Netherlands)

    de Visser, Matthias; Faems, D.L.M.

    2010-01-01

    Innovation requires a combination of explorative and exploitative innovation activities. Previous studies have provided valuable insights in the antecedents of investing in explorative and exploitative activities, the structural governance of exploration and exploitation and the performance

  15. Hotel innovation and its effect on business performance

    DEFF Research Database (Denmark)

    Mattsson, Jan; Orfila-Sintes, Francina

    2014-01-01

    This paper explores the dynamics of hotel innovation and its impact on hotel performance with a representative sample of the whole hotel sector operating in the Balearic Islands, Spain. The managers of sampled hotels (N = 331) answered questions about innovations over a 6-year period. On the basis...... of an earlier developed model of innovation types, we investigate the effect on performance of different types of innovation. We find that two combinations of innovation types impact hotel performance in a positive way, namely the combinations termed, Full and Service&Back-Office innovation. We therefore...

  16. Convergent innovation for sustainable economic growth and affordable universal health care: innovating the way we innovate.

    Science.gov (United States)

    Dubé, Laurette; Jha, Srivardhini; Faber, Aida; Struben, Jeroen; London, Ted; Mohapatra, Archisman; Drager, Nick; Lannon, Chris; Joshi, P K; McDermott, John

    2014-12-01

    This paper introduces convergent innovation (CI) as a form of meta-innovation-an innovation in the way we innovate. CI integrates human and economic development outcomes, through behavioral and ecosystem transformation at scale, for sustainable prosperity and affordable universal health care within a whole-of-society paradigm. To this end, CI combines technological and social innovation (including organizational, social process, financial, and institutional), with a special focus on the most underserved populations. CI takes a modular approach that convenes around roadmaps for real world change-a portfolio of loosely coupled complementary partners from the business community, civil society, and the public sector. Roadmaps serve as collaborative platforms for focused, achievable, and time-bound projects to provide scalable, sustainable, and resilient solutions to complex challenges, with benefits both to participating partners and to society. In this paper, we first briefly review the literature on technological innovation that sets the foundations of CI and motivates its feasibility. We then describe CI, its building blocks, and enabling conditions for deployment and scaling up, illustrating its operational forms through examples of existing CI-sensitive innovation. © 2014 The New York Academy of Sciences.

  17. Innovative Pedagogy

    DEFF Research Database (Denmark)

    and educational changes might challenge or facilitate learning for students and educators. Besides its relevance within the education sector, the content presented here can be applied in non-formal learning environments, such as museums, cultural institutions, as well as other educational settings where emotions......The main purpose of this book is to take a closer look at how students and teachers in educational institutions apply the innovative, the playful and the emotional and creative dimensions of learning. With this contribution, the authors aim at reaching an international audience of educators......-cultural perspective that looks at interactions among individuals; the creation and recreation of the self and others; and the study of collaboration, change processes and aesthetic and creative learning. This anthology offers original empirical documentation and theoretical reflections on how pedagogical...

  18. Innovators Intent

    DEFF Research Database (Denmark)

    Granados, Maria Luisa; Rai, Sudhanshu

    With this paper we want to explore further the innovators intent, where social enterprises use imaginative ways to take advantage of information technology to create, share and manage the knowledge pool of their small enterprise. We draw on several perspectives on how information processing needs...... are addressed, as well as the manner in which IT enables and facilitates sense-making. Studies exploring the role of IT in organisations abound, however our focus is not large organisations but small social enterprises (SEs) and how they use IT to further their business objectives. Hence there is still a lack......, and less the collaborative work and communication among enterprise members. However, it was established that SEs were using different technologies, such as, cloud solutions and web 2.0 tools to manage informally their knowledge. The possible impediments for SEs to support themselves more on IT solutions...

  19. Funding innovation

    CERN Multimedia

    Marina Giampietro

    2012-01-01

    For the first time, six knowledge and technology transfer activities are set to benefit from a dedicated fund made available by the Knowledge Transfer group. This initiative cements CERN’s commitment to sharing its technological knowledge and expertise with society.   GEM detectors for flame detection and early earthquake prediction, radio-frequency absorbers for energy recovery, and exotic radioisotopes for medical applications are among the projects funded by the recently introduced KT Fund. “CERN’s scientific programme generates a considerable amount of intellectual property, a natural driver for innovation,” explains Giovanni Anelli, Head of the Knowledge Transfer Group. “Very often, though, financial support is needed to bring the newly-born technologies a step further and make them ready for transfer to other research institutes or to companies.” This is where the KT fund comes into play. It provides vital support in the early sta...

  20. ASSESSMENT OF QUALITY OF INNOVATIVE TECHNOLOGIES

    OpenAIRE

    Larisa Alexejevna Ismagilova; Nadegda Aleksandrovna Sukhova

    2016-01-01

    We consider the topical issue of implementation of innovative technologies in the aircraft engine building industry. In this industry, products with high reliability requirements are developed and mass-produced. These products combine the latest achievements of science and technology. To make a decision on implementation of innovative technologies, a comprehensive assessment is carried out. It affects the efficiency of the innovations realization. In connection with this, the assessment of qu...

  1. THE INTERNATIONAL EXPERIENCE OF INTERACTION BETWEEN GOVERNMENT AND BUSINESS IN THE SPHERE OF INNOVATION: NEW TOOLS FOR INDUSTRIAL DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Anastasiya Yurievna Nikitaeva

    2015-09-01

    Full Text Available The article is devoted to the study of international experience of interaction between government and business in the innovative development of the industrial sector. Purpose of the paper is to determine the features and content of the new mechanisms of industrial development, based on integration platform of economic agents’ partnership.Methodology. The complex of system, synergy, institutional, evolutionary, and endogenous approaches is used as a methodological basis of research. Methodological apparatus of the article is presented by methods of the analysis, synthesis, abstraction, logical generalization.Results: the assessment of influence of government and commercial structures partnership on the innovative industrial development is given; the tendency of expansion of a partnership segment in the innovative sphere of the industry is empirically illustrated; features and key technologies of the new integration mechanism of industrial development are given.Conclusion: complication of innovative processes in combination with other factors results in expediency of development of partnership of economic entities in the sphere of industrial development. The extent and effectiveness of partnership practices in innovation is largely determined by the role of state institutions. For innovation of industrial development it is expedient to form the mechanisms using the integrated capacity of public and private institutions.Practical implications: the results of the study can be used in the justification of the priorities and measures of the state innovation and industrial policy, the development of concepts and programs of clustering of the regions and the development of public-private partnerships, and also formation of strategy of development of industrial structures.

  2. Designing collaborative policy innovation

    DEFF Research Database (Denmark)

    Agger, Annika; Sørensen, Eva

    2014-01-01

    Recent approaches to enhancing public innovation suffer from two shortcomings: They overemphasize competition as a driver of innovation and overlook the fact that public sector innovation involves policy innovation as well as service innovation. Drawing on governance research and innovation theory......, the chapter investigates the extent to which and how collaboration between politicians and relevant stakeholders can spur the formulation, implementation and diffusion of new innovative policies. A case study of a process of collaborative policy innovation in a Danish municipality shows that collaborative...... policy arenas do contribute to policy innovation but also that the degree to which they do so depends on the institutional design of these arenas....

  3. Innovation agenda

    International Nuclear Information System (INIS)

    Kammen, Daniel M.

    2008-01-01

    Retooling the global economy for a low-carbon and environmentally responsible future must begin immediately - and a major new United States initiative in this area is vital. The recent downturn in the economy makes this change all the more necessary: energy efficiency and renewable energy can be an engine of dramatic new economic growth and job creation. It will be up to the incoming president to marshal public and industry sentiment behind such a reinvestment in our future. We are at last seeing a global explosion of financial and political interest in energy, focused largely - but, ominously, not exclusively - on clean energy, since, in addition, to solar, wind and other low-carbon sources, investments in some of the most CO 2 -intensive sources are also on the rise. Innovation is the life-blood of economic growth and renewal. It has been known for decades that the bulk of new growth results from the invention, and re-invention, of new scientific and technological opportunities. Over 50 years ago Economics Nobel Laureate Robert Solow concluded that over 90 per cent of new economic growth results from public and private sector investments in innovation. Yet energy is very short of investment in research and development (R and D) despite arguably now posing our top environmental and geopolitical security threat. Total investment on R and D in the U.S. as a whole stands at roughly three per cent of the U.S. gross domestic product, but, for energy, it is proportionally only about one-tenth of that level. By contrast, research and development investments in the medical and biotechnology field are roughly 15 per cent of sales - almost a staggering 40 times more than for energy. This argues that, at minimum, energy R and D should be increased to the three per cent national average

  4. Creativity and Innovation

    DEFF Research Database (Denmark)

    Brem, Alexander; Puente-Diaz, Rogelio; Agogue, Marine

    2016-01-01

    Creativity is a vibrant field of scientific research with important applied implications for the management of innovation. In this article, we argue that the proliferation of creativity research has led to positive and less positive outcomes and discuss five relevant research themes. We first...... introduce our readers to the different proposed dimensions of a creative object. Next, we explain recent developments on the level of the creativity magnitude issue. Based on that, we review how researchers currently operationalize creativity. After discussing how creativity is conceptualized...... and operationalized, we outline how it might be enhanced. Finally, we present an overview of the wide variety of methodological approaches currently used in creativity research. We close by calling for more interdisciplinary research and offering other suggestions for future directions....

  5. Creativity and Innovation

    DEFF Research Database (Denmark)

    Brem, Alexander; Puente-Diaz, Rogelio; Agogue, Marine

    2016-01-01

    Creativity is a vibrant field of scientific research with important applied implications for the management of innovation. In this article, we argue that the proliferation of creativity research has led to positive and less positive outcomes and discuss five relevant research themes. We first...... and operationalized, we outline how it might be enhanced. Finally, we present an overview of the wide variety of methodological approaches currently used in creativity research. We close by calling for more interdisciplinary research and offering other suggestions for future directions....... introduce our readers to the different proposed dimensions of a creative object. Next, we explain recent developments on the level of the creativity magnitude issue. Based on that, we review how researchers currently operationalize creativity. After discussing how creativity is conceptualized...

  6. Testing methodologies

    Energy Technology Data Exchange (ETDEWEB)

    Bender, M.A.

    1990-01-01

    Several methodologies are available for screening human populations for exposure to ionizing radiation. Of these, aberration frequency determined in peripheral blood lymphocytes is the best developed. Individual exposures to large doses can easily be quantitated, and population exposures to occupational levels can be detected. However, determination of exposures to the very low doses anticipated from a low-level radioactive waste disposal site is more problematical. Aberrations occur spontaneously, without known cause. Exposure to radiation induces no new or novel types, but only increases their frequency. The limitations of chromosomal aberration dosimetry for detecting low level radiation exposures lie mainly in the statistical signal to noise'' problem, the distribution of aberrations among cells and among individuals, and the possible induction of aberrations by other environmental occupational or medical exposures. However, certain features of the human peripheral lymphocyte-chromosomal aberration system make it useful in screening for certain types of exposures. Future technical developments may make chromosomal aberration dosimetry more useful for low-level radiation exposures. Other methods, measuring gene mutations or even minute changes on the DNA level, while presently less will developed techniques, may eventually become even more practical and sensitive assays for human radiation exposure. 15 refs.

  7. Testing methodologies

    International Nuclear Information System (INIS)

    Bender, M.A.

    1990-01-01

    Several methodologies are available for screening human populations for exposure to ionizing radiation. Of these, aberration frequency determined in peripheral blood lymphocytes is the best developed. Individual exposures to large doses can easily be quantitated, and population exposures to occupational levels can be detected. However, determination of exposures to the very low doses anticipated from a low-level radioactive waste disposal site is more problematical. Aberrations occur spontaneously, without known cause. Exposure to radiation induces no new or novel types, but only increases their frequency. The limitations of chromosomal aberration dosimetry for detecting low level radiation exposures lie mainly in the statistical ''signal to noise'' problem, the distribution of aberrations among cells and among individuals, and the possible induction of aberrations by other environmental occupational or medical exposures. However, certain features of the human peripheral lymphocyte-chromosomal aberration system make it useful in screening for certain types of exposures. Future technical developments may make chromosomal aberration dosimetry more useful for low-level radiation exposures. Other methods, measuring gene mutations or even minute changes on the DNA level, while presently less will developed techniques, may eventually become even more practical and sensitive assays for human radiation exposure. 15 refs

  8. Capabilities for innovation

    DEFF Research Database (Denmark)

    Nielsen, Peter; Nielsen, Rene Nesgaard; Bamberger, Simon Grandjean

    2012-01-01

    is a survey that collected information from 601 firms belonging to the private urban sector in Denmark. The survey was carried out in late 2010. Keywords: dynamic capabilities/innovation/globalization/employee/employer cooperation/Nordic model Acknowledgment: The GOPA study was financed by grant 20080053113......Technological developments combined with increasing levels of competition related to the ongoing globalization imply that firms find themselves in dynamic, changing environments that call for dynamic capabilities. This challenges the internal human and organizational resources of firms in general...

  9. Comparative study on software development methodologies

    OpenAIRE

    Mihai Liviu DESPA

    2014-01-01

    This paper focuses on the current state of knowledge in the field of software development methodologies. It aims to set the stage for the formalization of a software development methodology dedicated to innovation orientated IT projects. The paper starts by depicting specific characteristics in software development project management. Managing software development projects involves techniques and skills that are proprietary to the IT industry. Also the software development project manager han...

  10. Nonlinear Aerodynamic ROM-Structural ROM Methodology for Inflatable Aeroelasticity in Hypersonic Atmospheric Entry, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — ZONA Technology proposes to develop an innovative nonlinear structural reduced order model (ROM) - nonlinear aerodynamic ROM methodology for the inflatable...

  11. AN ANALYSIS OF FEMALE ENTREPRENEURSHIP AND INNOVATION IN SERBIA IN THE CONTEXT OF EU COMPETITIVENESS

    OpenAIRE

    Sanja Popovic Pantic

    2014-01-01

    In economies that are led by innovation, innovativeness and competitiveness are interdependent. If an enterprise and/or economy is competitive in the market it will likely have a high level of innovation management, harmonized with EU standards. A variety of different methodologies is used to assess the innovation capacities of small and medium sized companies, but IMPіrove methodology is widespread in EU countries. It is a benchmarking process which gives,...

  12. Strategic knowledge management: a methodology for structuring and analysing knowledge resources

    International Nuclear Information System (INIS)

    Ricciardi, Rita Izabel

    2009-01-01

    This work presents a methodology to organize, to classify and to assess the knowledge resources of an organization. This methodology presents an innovative integration of the following elements: (a) a systemic vision of the organization; (b) a representation maps of organization strategy; (c) the identification of relevant knowledge through process analysis; (d) the reconfiguration and representation of the identified knowledge in maps; (e) a combination of critical analysis (importance and vulnerability) and of strategic analysis to assess knowledge. Such methodology was applied to the Radiopharmaceutical Center of Nuclear and Energetic Research Institute resulting in a very rich vision and understanding of the knowledge domains that are crucial to the CR. This kind of analysis has allowed a sharp perception of the knowledge problems of the Center and has also made visible the needed connections between Strategic Management and Knowledge Management. (author)

  13. Transparent Guideline Methodology Needed

    DEFF Research Database (Denmark)

    Lidal, Ingeborg; Norén, Camilla; Mäkelä, Marjukka

    2013-01-01

    As part of learning at the Nordic Workshop of Evidence-based Medicine, we have read with interest the practice guidelines for central venous access, published in your Journal in 2012.1 We appraised the quality of this guideline using the checklist developed by The Evidence-Based Medicine Working ...... are based on best currently available evidence. Our concerns are in two main categories: the rigor of development, including methodology of searching, evaluating, and combining the evidence; and editorial independence, including funding and possible conflicts of interest....... Group.2 Similar criteria for guideline quality have been suggested elsewhere.3 Our conclusion was that this much needed guideline is currently unclear about several aspects of the methodology used in developing the recommendations. This means potential users cannot be certain that the recommendations...

  14. International Innovation Cooperation with a View to Innovative Development

    Directory of Open Access Journals (Sweden)

    Kramarenko Ruslan M.

    2016-02-01

    Full Text Available Currently the process of globalization in the field of scientific, technical and industrial activity continues to grow. Countries conclude bilateral and multilateral agreements to facilitate cooperation in scientific research and co-financing of capital-intensive innovation projects. Combining competitive advantages of companies is motivated by the government’s policy with respect to attracting foreign direct investments and entering new markets. Despite some discomfort of countries of the world caused by the outflow of knowledge abroad and disturbance of the equilibrium of the trade balance, most of the countries of the OECD have scientific and economic benefits from these transactions. The processes associated with innovations are constantly in the focus of attention of local and foreign experts and are reflected in their works. The aim of the article is to analyze the impact of international integration interaction of countries of the world on innovative development. The forms of internationalization of innovation activities have been analyzed. The main vector of the modern global competition based on scientific and technological achievements and innovations has been determined. The main directions of the internationalization of innovation activities have been revealed and justified

  15. Towards a synergic innovation management model: the interplay of market, technology, and management innovations

    Directory of Open Access Journals (Sweden)

    Leonard Tchuta

    2017-03-01

    Full Text Available This paper outlines a model of firm innovation management known as the synergic innovation management model. Building on the theory of dynamic capabilities and core competence, the paper suggest three capabilities of firms namely market, technology, management capabilities that drive firms’ innovations. The combination of these three capabilities creates a unique configuration for a firm known as the firm’s core competence that informs the firm's strategic decisions. The synergic innovation management model guides firm in the simultaneous exploration of market, technology, and management innovations required for sustainable business. The paper concludes with limitations of the model and suggestions for further research.

  16. Sustainable Innovation in the Dutch Construction Industry

    NARCIS (Netherlands)

    D. (Damon) Hassanpur Golriz; H.J. (Henk) Schout; dr. MBA S.J.M. (Saskia) Harkema

    2010-01-01

    Since the film of Al Gore An inconvenient truth, sustainability stands high on the national agenda of most countries. Concern for the environment is one of the main reasons in combination with opportunities to innovate. In general, innovation and entrepreneurship are important in the realm of

  17. Optimal diversity in investments with recombinant innovation

    NARCIS (Netherlands)

    Zeppini, P.; van den Bergh, J.C.J.M.

    2013-01-01

    The notion of dynamic, endogenous diversity and its role in theories of investment and technological innovation is addressed. We develop a formal model of an innovation arising from the combination of two existing modules, with the objective to optimize the net benefits of diversity. The model takes

  18. Optimal diversity in investments with recombinant innovation

    NARCIS (Netherlands)

    Zeppini-Rossi, P.; van den Bergh, J.C.J.M.

    2008-01-01

    The notion of dynamic, endogenous diversity and its role in theories of investment and technological innovation is addressed. We develop a formal model of an innovation arising from the combination of two existing modules with the objective to optimize the net benefits of diversity. The model takes

  19. Marketing communications model for innovation networks

    Directory of Open Access Journals (Sweden)

    Tiago João Freitas Correia

    2015-10-01

    Full Text Available Innovation is an increasingly relevant concept for the success of any organization, but it also represents a set of internal and external considerations, barriers and challenges to overcome. Along the concept of innovation, new paradigms emerge such as open innovation and co-creation that are simultaneously innovation modifiers and intensifiers in organizations, promoting organizational openness and stakeholder integration within the value creation process. Innovation networks composed by a multiplicity of agents in co-creative work perform as innovation mechanisms to face the increasingly complexity of products, services and markets. Technology, especially the Internet, is an enabler of all process among organizations supported by co-creative platforms for innovation. The definition of marketing communication strategies that promote motivation and involvement of all stakeholders in synergic creation and external promotion is the central aspect of this research. The implementation of the projects is performed by participative workshops with stakeholders from Madan Parque through IDEAS(REVOLUTION methodology and the operational model LinkUp parameterized for the project. The project is divided into the first part, the theoretical framework, and the second part where a model is developed for the marketing communication strategies that appeal to the Madan Parque case study. Keywords: Marketing Communication; Open Innovation, Technology; Innovation Networks; Incubator; Co-Creation.

  20. A model for 'reverse innovation' in health care.

    Science.gov (United States)

    Depasse, Jacqueline W; Lee, Patrick T

    2013-08-30

    'Reverse innovation,' a principle well established in the business world, describes the flow of ideas from emerging to more developed economies. There is strong and growing interest in applying this concept to health care, yet there is currently no framework for describing the stages of reverse innovation or identifying opportunities to accelerate the development process. This paper combines the business concept of reverse innovation with diffusion of innovation theory to propose a model for reverse innovation as a way to innovate in health care. Our model includes the following steps: (1) identifying a problem common to lower- and higher-income countries; (2) innovation and spread in the low-income country (LIC); (3) crossover to the higher-income country (HIC); and (4) innovation and spread in the HIC. The crucial populations in this pathway, drawing from diffusion of innovation theory, are LIC innovators, LIC early adopters, and HIC innovators. We illustrate the model with three examples of current reverse innovations. We then propose four sets of specific actions that forward-looking policymakers, entrepreneurs, health system leaders, and researchers may take to accelerate the movement of promising solutions through the reverse innovation pipeline: (1) identify high-priority problems shared by HICs and LICs; (2) create slack for change, especially for LIC innovators, LIC early adopters, and HIC innovators; (3) create spannable social distances between LIC early adopters and HIC innovators; and (4) measure reverse innovation activity globally.

  1. Organizing Systemic Innovation

    NARCIS (Netherlands)

    F.P.H. Jaspers (Ferdinand)

    2009-01-01

    textabstractSystemic innovation refers to product development activities that involve the change of multiple interdependent components. Unlike autonomous innovation, which refers to components that change independently, systemic innovation is for many firms the norm rather than the exception. This

  2. Innovation in Your Community

    Science.gov (United States)

    EPA has many innovation programs that can help the public bring innovative solutions to their local areas by reducing waste, engaging students to contribute innovative ideas, and helping businesses implement sustainable practices.

  3. Creativity and group innovation

    NARCIS (Netherlands)

    Nijstad, B.A.; de Dreu, C.K.W.

    2002-01-01

    Comments on M. West's article regarding the validity of an integrative model of creativity and innovation implementation in work groups. Variables affecting the level of team innovation; Relationship between predictors and team innovation; Promotion of constructive conflict.

  4. Innovative and Alternative Technology Assessment Manual

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-02-01

    This four chapter, six appendix manual presents the procedures and methodology as well as the baseline costs and energy information necessary for the analysis and evaluation of innovative and alternative technology applications submitted for federal grant assistance under the innovative and alternative technology provisions of the Clean Water Act of 1977. The manual clarifies and interprets the intent of Congress and the Environmental Protection Agency in carrying out the mandates of the innovative and alternative provisions of the Clean Water Act of 1977. [DJE 2005

  5. Comparative study on software development methodologies

    Directory of Open Access Journals (Sweden)

    Mihai Liviu DESPA

    2014-12-01

    Full Text Available This paper focuses on the current state of knowledge in the field of software development methodologies. It aims to set the stage for the formalization of a software development methodology dedicated to innovation orientated IT projects. The paper starts by depicting specific characteristics in software development project management. Managing software development projects involves techniques and skills that are proprietary to the IT industry. Also the software development project manager handles challenges and risks that are predominantly encountered in business and research areas that involve state of the art technology. Conventional software development stages are defined and briefly described. Development stages are the building blocks of any software development methodology so it is important to properly research this aspect. Current software development methodologies are presented. Development stages are defined for every showcased methodology. For each methodology a graphic representation is illustrated in order to better individualize its structure. Software development methodologies are compared by highlighting strengths and weaknesses from the stakeholder's point of view. Conclusions are formulated and a research direction aimed at formalizing a software development methodology dedicated to innovation orientated IT projects is enunciated.

  6. Open innovation and intellectual property rights

    DEFF Research Database (Denmark)

    Brem, Alexander; Nylund, Petra A.; Hitchen, Emma L.

    2017-01-01

    . Design/methodology/approach: The relationships between open innovation, IPRs, and profitability are tested with random-effects panel regressions on data from the Spanish Community Innovation Survey for 2,873 firms spanning the years 2008-2013. Findings: A key result is that SMEs do not benefit from open......Purpose: The purpose of this paper is to study the relationship between open innovation and the use of intellectual property rights (IPRs) in small- and medium-sized enterprises (SMEs). The authors consider patents, industrial designs (i.e. design patents in the USA), trademarks, and copyrights...... innovation or from patenting in the same way as larger firms. Furthermore, the results show that SMEs profit in different ways from IPR, depending on their size and the corresponding IPR. Research limitations/implications: The different impact of IPRs on the efficiency of open innovation in firms of varying...

  7. Match your innovation strategy to your innovation ecosystem.

    Science.gov (United States)

    Adner, Ron

    2006-04-01

    High-definition televisions should, by now, be a huge success. Philips, Sony, and Thompson invested billions of dollars to develop TV sets with astonishing picture quality. From a technology perspective, they've succeeded: Console manufacturers have been ready for the mass market since the early 1990s. Yet the category has been an unmitigated failure, not because of deficiencies, but because critical complements such as studio production equipment were not developed or adopted in time. Under-performing complements have left console producers in the position of offering a Ferrari in a world without gasoline or highways--an admirable engineering feat, but not one that creates value for customers. The HDTV story exemplifies the promise and peril of innovation ecosystems--the collaborative arrangements through which firms combine their individual offers into a coherent, customer-facing solution. When they work, innovation ecosystems allow companies to create value that no one firm could have created alone. The benefits of these systems are real. But for many organizations the attempt at ecosystem innovation has been a costly failure. This is because, along with new opportunities, innovation ecosystems also present a new set of risks that can brutally derail a firm's best efforts. Innovation ecosystems are characterized by three fundamental types of risk: initiative risks--the familiar uncertainties of managing a project; interdependence risks--the uncertainties of coordinating with complementary innovators; and integration risks--the uncertainties presented by the adoption process across the value chain. Firms that assess ecosystem risks holistically and systematically will be able to establish more realistic expectations, develop a more refined set of environmental contingencies, and arrive at a more robust innovation strategy. Collectively, these actions will lead to more effective implementation and more profitable innovation.

  8. Workplace innovation and social innovation : an introduction

    NARCIS (Netherlands)

    Jürgen Howaldt; Dr. Ben Fruytier; Peter R.A. Oeij; Steven Dhondt

    2016-01-01

    This is the introduction to the special issue of World Review of Entrepreneurship, Management and Sustainable Development (WREMSD) dedicated to workplace innovation and social innovation related to work and organisation. As technological and business model innovations alone are not sufficient to

  9. Workplace innovation and social innovation: an introduction

    NARCIS (Netherlands)

    Howaldt, J.; Oeij, P.R.A.; Dhondt, S.; Fruytier, B.

    2016-01-01

    This is the introduction to this special issue of World Review of Entrepreneurship, Management and Sustainable Development (WREMSD) dedicated to workplace innovation and social innovation related to work and organisation. As technological and business model innovations alone are not sufficient to

  10. Speeding Up Innovation

    DEFF Research Database (Denmark)

    Sørensen, Flemming; Mattsson, Jan

    2016-01-01

    Minimisation of time-to-market strategies can provide companies with a competitive advantage in dynamic and competitive environments. Using parallel innovation processes has been emphasised as one strategy to speed up innovation processes and consequently minimise the time-to-market of innovations....... Much innovation today takes place in open structures in which networks play an important role. However, little is known about how innovation networks can facilitate parallel innovation processes. This paper discusses how innovation network structures develop and support exploration and exploitation...... of the network facilitate the parallel innovation process but also how such processes place new requirements on such networks and their management....

  11. Singlet-oxygen therapy. Scientific and methodological materials

    OpenAIRE

    Chukhraiev, N.; Chukhraieva, E.; Gun'ko, M.; Kurik, L.; Lomeiko, S.; Marushko, Y.; Samosyuk, N.; Tkalina, A.; Vladimirov, A.; Unichenko, A.; Zavorotnaya, R.; Zukow, W.

    2018-01-01

    Radomska Szkoła Wyższa w Radomiu MEDICAL INNOVATIVE TECHNOLOGIES SINGLET-OXYGEN THERAPY Scientific and methodological materials 2018 This edition had extended and translated from ukrainian Edited by Chukhraiev N., Vladimirov A., Zukow W. Radom, Kyiv Radomska Szkoła Wyższa w Radomiu MEDICAL INNOVATIVE TECHNOLOGIES SINGLET-OXYGEN THERAPY Scientific and methodological materials 2018 This edition had extended and translated from ukrainian Edited by ...

  12. Conflict, Coincidence And Emerging Interactions As Logics Of Innovation

    DEFF Research Database (Denmark)

    Gottlieb, Frederik

    2016-01-01

    This paper seeks out to construct a model of innovation based on research conducted in 3 different entrepreneurial contexts. The model attempts to describe how innovation is emerging in the everyday interactions of people involved in the projects, through conversations in meetings, on social media...... and in workshops. Based on the presented model, the author will discuss how logics of innovation can be seen in a new perspective in the light of Sarasvathys theory of Effectuation. The research methodology is based on Participatory Innovation (Buur & Matthews 2008) with a strong emphasis on involving many...... projects, how the process of innovation emerge in the interactions of the people involved, including the researcher himself....

  13. Sustainability and Cities as Systems of Innovation

    DEFF Research Database (Denmark)

    Johnson, Bjørn; Lehmann, Martin

    Cities often constitute relevant environments for interactive learning and innovation potentially capable of tackling sustainability problems. In this paper we ask if the concept of systems of innovation can increase our understanding of city dynamics and help promoting the sustainable development...... of cities. Through a combination of the innovation system approach and the perspective of creative cities, we argue that a slightly modified concept – sustainable city systems of innovation – may be helpful in this context. To underline this, we discuss certain ‘city-traits’ of sustainability and conclude...

  14. Enhancing policy innovation by redesigning representative democracy

    DEFF Research Database (Denmark)

    Sørensen, Eva

    2016-01-01

    Policy innovation is a key aspect of public innovation, which has been largely overlooked. Political leadership, competition and collaboration are key drivers of policy innovation. It is a barrier in traditional models of representative democracy that they provide weak conditions for collaboration....... Two Danish case studies indicate that collaboration between politicians and relevant and affected stakeholders can promote policy innovation, but also that a redesign of representative democracy is needed in order to establish a productive combination of political leadership, competition...... and collaboration in political life....

  15. Alternative pricing methodologies

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    With the increased interest in competitive market forces and growing recognition of the deficiencies in current practices, FERC and others are exploring alternatives to embedded cost pricing. A number of these alternatives are discussed in this chapter. Marketplace pricing, discussed briefly here, is the subject of the next chapter. Obviously, the pricing formula may combine several of these methodologies. One utility of which the authors are aware is seeking a price equal to the sum of embedded costs, opportunity costs, line losses, value of service, FERC's percentage adder formula and a contract service charge

  16. EVOLVING AN EMPIRICAL METHODOLOGY DOR DETERMINING ...

    African Journals Online (AJOL)

    The uniqueness of this approach, is that it can be applied to any forest or dynamic feature on the earth, and can enjoy universal application as well. KEY WORDS: Evolving empirical methodology, innovative mathematical model, appropriate interval, remote sensing, forest environment planning and management. Global Jnl ...

  17. From experience : applying the risk diagnosing methodology

    NARCIS (Netherlands)

    Keizer, J.A.; Halman, J.I.M.; Song, X.M.

    2002-01-01

    No risk, no reward. Companies must take risks to launch new products speedily and successfully. The ability to diagnose and manage risks is increasingly considered of vital importance in high-risk innovation. This article presents the Risk Diagnosing Methodology (RDM), which aims to identify and

  18. From experience: applying the risk diagnosing methodology

    NARCIS (Netherlands)

    Keizer, Jimme A.; Halman, Johannes I.M.; Song, Michael

    2002-01-01

    No risk, no reward. Companies must take risks to launch new products speedily and successfully. The ability to diagnose and manage risks is increasingly considered of vital importance in high-risk innovation. This article presents the Risk Diagnosing Methodology (RDM), which aims to identify and

  19. The IAEA international project on innovative nuclear reactors and fuel cycles (INPRO): Status, ongoing activities and outlook

    International Nuclear Information System (INIS)

    Kupitz, J.; Depisch, F.; Khorochev, M.

    2004-01-01

    The IAEA General Conference (2000) invited 'all interested Member States to combine their efforts under the aegis of the IAEA in considering the issues of the nuclear fuel cycle, in particular by examining innovative and proliferation-resistant nuclear technology'. In response to this invitation, the IAEA initiated the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO). The overall objectives of INPRO are to help to ensure that nuclear energy is available to contribute in fulfilling energy needs in the 21 st century in a sustainable manner; and to bring together both technology holders and technology users to consider jointly the international and national actions required to achieve desired innovations in nuclear reactors and fuel cycles. INPRO is addressing the identification of full spectrum of user requirements for innovative technologies as well as the development of methodologies and guidelines for the comparison of different innovative approaches taking into account variations in potential demands across countries. INPRO can make major contributions by focusing on economic aspects, and societal acceptability issues and those areas where IAEA can make unique contributions such as proliferation resistance, nuclear safety, waste management and sustainability issues and providing assistance to the user community. To enhance the potential for the deployment of innovative technologies, some changes in the infrastructure under which nuclear energy is developed and used; should be envisaged. In order to fulfil these objectives, the first phase of INPRO dealt with the development of a methodology to assess and compare the performance of innovative nuclear energy systems (INS). This methodology includes the definition of a set of Basic principles, User requirements and Criteria to be met in different areas (Economics, Sustainability and environment, Safety of nuclear installations, Waste management and Proliferation resistance). The result of

  20. A review of the Mexican national innovation system

    Directory of Open Access Journals (Sweden)

    Samantha Rullán

    2015-12-01

    Full Text Available Governments and business leaders are increasingly aware of the role that innovation plays in economic growth, development and competitiveness. There are imperative challenges for Latin American countries, among them, poverty, social inclusion, sustainable development, climate change, natural disasters, productivity, improve the quality of education and health. Innovations are essential to drive economic growth and prosperity in the region. According to the Global Innovation Index (2015, Mexico is ranked 57th. Most of the research on innovation performance is mostly focused on technological innovation. Therefore, the main variables used, such as patents and number of scientific publications, do not always reflect the other types of innovations (i.e. business model, organizational, etc. that are developing in emerging markets. The aim of this paper is to analyze the Mexican innovation system using a broad concept with a focus on other types of innovation including cultural aspects to identify the main characteristics that distinguish and determine how innovation in Mexico is formed. Although the Mexican government has improved its institutional structure for innovation and its support policies, they need to evaluate programs and adjust incentive schemes based on performance to improve their innovation policy. Purpose – The purpose of this paper is to examine the Mexican National Innovation System using a broad concept with a focus on other types of innovation and including cultural aspects to identify some of the main characteristics that determine how innovation in Mexico is formed. Design/methodology/approach – The national innovation systems framework is used to review the Mexican innovation policy.A review of relevant literature on national innovation systems and Mexican innovation policies with data from the Global Innovation Index and INEGI were used for this paper. Findings – Higher private investment in R&D is needed to enhance