WorldWideScience

Sample records for methodological features age

  1. Evolution of aging assessment methodologies

    International Nuclear Information System (INIS)

    McCrea, L.; Dam, R.; Gold, R.

    2011-01-01

    Under the influence of organizations like the IAEA and INPO the expectations of the regulator and plant operators alike are driving the evolution of aging assessment methodologies. The key result is that these assessments need to be executed more efficiently while supporting risk informed thinking within a living process. Some recent trends impacting aging assessments include new standards from the regulator requiring more frequent updates of aging assessments (RD-334), and broader component coverage driven by equipment reliability program demands (INPO AP-913). These trends point to the need to be able to do aging assessment more efficiently, and to manage the configuration. Some of the challenges include increasing efficiency while maintaining completeness and minimizing error, employing a systematic, well defined approach while maintaining the flexibility to apply the right level of effort to achieve desired results, and in particular, assuring that Aging Related Degradation Mechanisms (ARDMs) are sufficiently addressed. Meeting these needs creates a natural synergy with the Preventive Maintenance living program and therefore lends itself to a more integrated approach. To support this program, the SYSTMSTM software has been enhanced to accommodate for the various facets of an integrated program while meeting the needs described above. The systematic processes in SYSTMS are built with the vision of supporting risk-informed decision making as part of a larger risk-based functional tools suite. This paper intends to show how the utilities can benefit from the cost savings associated with increased assessment efficiency, and utilizing Candu Energy Inc.'s CANDU-specific knowledge-base and experience in aging assessment to get it right the first time. (author)

  2. Evolution of aging assessment methodologies

    Energy Technology Data Exchange (ETDEWEB)

    McCrea, L.; Dam, R.; Gold, R. [Candu Energy Inc., Mississauga, Ontario (Canada)

    2011-07-01

    Under the influence of organizations like the IAEA and INPO the expectations of the regulator and plant operators alike are driving the evolution of aging assessment methodologies. The key result is that these assessments need to be executed more efficiently while supporting risk informed thinking within a living process. Some recent trends impacting aging assessments include new standards from the regulator requiring more frequent updates of aging assessments (RD-334), and broader component coverage driven by equipment reliability program demands (INPO AP-913). These trends point to the need to be able to do aging assessment more efficiently, and to manage the configuration. Some of the challenges include increasing efficiency while maintaining completeness and minimizing error, employing a systematic, well defined approach while maintaining the flexibility to apply the right level of effort to achieve desired results, and in particular, assuring that Aging Related Degradation Mechanisms (ARDMs) are sufficiently addressed. Meeting these needs creates a natural synergy with the Preventive Maintenance living program and therefore lends itself to a more integrated approach. To support this program, the SYSTMSTM software has been enhanced to accommodate for the various facets of an integrated program while meeting the needs described above. The systematic processes in SYSTMS are built with the vision of supporting risk-informed decision making as part of a larger risk-based functional tools suite. This paper intends to show how the utilities can benefit from the cost savings associated with increased assessment efficiency, and utilizing Candu Energy Inc.'s CANDU-specific knowledge-base and experience in aging assessment to get it right the first time. (author)

  3. Perceived age as a biomarker of ageing: a clinical methodology

    DEFF Research Database (Denmark)

    Gunn, David A; Murray, Peter G; Tomlin, Cyrena C

    2008-01-01

    In a previous field-based study, how old one looks for one's age (perceived age) was found to be predictive of mortality in elderly individuals. In conjunction, perceived age is of relevance and interest to the layperson. Here, a clinical methodology for generating perceived age as a biomarker...... of facial ageing is detailed. The methodology utilises facial photographs of subjects to present images to large numbers of age assessors who are primarily nationals of the country of study origin. In five observational studies in five different countries involving 874 female subjects it was found...... that subject age and assessor gender, nationality, age and ageing expertise had little effect on the perceived age data generated. However, increasing the numbers of age assessors up to 50 substantially increased the reproducibility of the mean perceived age for an image and a minimum of 10 assessors were...

  4. A new methodology for recognizing features in rotational parts using ...

    African Journals Online (AJOL)

    user

    An intelligent interface between CAD and CAPP systems is imperative because the ..... The Feature recognition methodology discussed in this work has several advantages over other ... Applied Artificial Intelligence, Vol.16, No.4, pp.303–331.

  5. The meaning of dwelling features : Conceptual and methodological issues

    NARCIS (Netherlands)

    Coolen, H.C.C.H.

    2008-01-01

    This study is about the meaning of dwelling features. It relates the research areas of housing preferences and the meaning of a dwelling with each other and with aspects of the means-end approach as applied in marketing research. It results in a conceptual and methodological framework for studying

  6. Aging, selective attention, and feature integration.

    Science.gov (United States)

    Plude, D J; Doussard-Roosevelt, J A

    1989-03-01

    This study used feature-integration theory as a means of determining the point in processing at which selective attention deficits originate. The theory posits an initial stage of processing in which features are registered in parallel and then a serial process in which features are conjoined to form complex stimuli. Performance of young and older adults on feature versus conjunction search is compared. Analyses of reaction times and error rates suggest that elderly adults in addition to young adults, can capitalize on the early parallel processing stage of visual information processing, and that age decrements in visual search arise as a result of the later, serial stage of processing. Analyses of a third, unconfounded, conjunction search condition reveal qualitatively similar modes of conjunction search in young and older adults. The contribution of age-related data limitations is found to be secondary to the contribution of age decrements in selective attention.

  7. [Physiological features of skin ageing in human].

    Science.gov (United States)

    Tikhonova, I V; Tankanag, A V; Chemeris, N K

    2013-01-01

    The issue deals with the actual problem of gerontology, notably physiological features of human skin ageing. In the present review the authors have considered the kinds of ageing, central factors, affected on the ageing process (ultraviolet radiation and oxidation stress), as well as the research guidelines of the ageing changes in the skin structure and fuctions: study of mechanical properties, microcirculation, pH and skin thickness. The special attention has been payed to the methods of assessment of skin blood flow, and to results of investigations of age features of peripheral microhemodynamics. The laser Doppler flowmetry technique - one of the modern, noninvasive and extensively used methods for the assessmant of skin blood flow microcirculation system has been expanded in the review. The main results of the study of the ageing changes of skin blood perfusion using this method has been also presented.

  8. An image-processing methodology for extracting bloodstain pattern features.

    Science.gov (United States)

    Arthur, Ravishka M; Humburg, Philomena J; Hoogenboom, Jerry; Baiker, Martin; Taylor, Michael C; de Bruin, Karla G

    2017-08-01

    There is a growing trend in forensic science to develop methods to make forensic pattern comparison tasks more objective. This has generally involved the application of suitable image-processing methods to provide numerical data for identification or comparison. This paper outlines a unique image-processing methodology that can be utilised by analysts to generate reliable pattern data that will assist them in forming objective conclusions about a pattern. A range of features were defined and extracted from a laboratory-generated impact spatter pattern. These features were based in part on bloodstain properties commonly used in the analysis of spatter bloodstain patterns. The values of these features were consistent with properties reported qualitatively for such patterns. The image-processing method developed shows considerable promise as a way to establish measurable discriminating pattern criteria that are lacking in current bloodstain pattern taxonomies. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. GENDER AND AGE FEATURES OF GLAUCOMA

    Directory of Open Access Journals (Sweden)

    O. V. Makarenk

    2014-02-01

    Full Text Available Today, the definition “glaucoma” combines a number of eye pathologies that lead to irreversible blindness, and therefore is difficult disabling disease. Glaucoma occurs in people of working age, so this problem is not only medical, but also social, because it causes disability in substantial economic costs not only for individual patients, but also for the whole country – patients become unable to work. Gender features of glaucoma are also contradictory. In European literature the basic idea is that men are more likely to suffer from glaucoma than women. Such studies have not been conducted in the Podillya region of Ukraine, that makes impossible to design a reliable global data to estimate the prevalence of glaucoma in different age groups for persons living in Vinnitsa region. Therefore, the aim of the study was a retrospective analysis of medical records of patients in Eye Microsurgery Department of Vinnitsa Regional Clinical Hospital for the period 2008-2012 years for determining the gender and age characteristics. Materials and methods 1418 patients with primary open-angle glaucoma (841 men and 577 women aged 14 to 92 years (mean age 67,12 ± 7,64, which were treated in the Eye Microsurgery Department, took part in the study. For the purpose of the study they were divided into two groups: I – male patients with glaucoma, II – female patients with glaucoma. Each group was divided into 7 subgroups according to the ontogenesis scheme: A – teens, B – youth, C – I adulthood age, D – II adulthood age, E – elderly age, F – senily age and G – centenarians. Thus was allocated 12 research groups. Results The structure of the incidence of glaucoma is 59.31% in men and 40.69% in women. Incidence of glaucoma is highest in the IE group and is 34.98%. The group IIE incidence is lower – 35.32%. In the group D the incidence of glaucoma among men and women was very different (13.89% and 2.89%, respectively. It should also be noted

  10. Methodology for featuring and assessing extreme climatic events

    International Nuclear Information System (INIS)

    Malleron, N.; Bernardara, P.; Benoit, M.; Parey, S.; Perret, C.

    2013-01-01

    The setting up of a nuclear power plant on a particular site requires the assessment of risks linked to extreme natural events like flooding or earthquakes. As a consequence of the Fukushima accident EDF proposes to take into account even rarer events in order to improve the robustness of the facility all over its operating life. This article presents the methodology used by EDF to analyse a set of data in a statistical way in order to extract extreme values. This analysis is based on the theory of extreme values and is applied to the extreme values of the flow rate in the case of a river overflowing. This methodology is made of 6 steps: 1) selection of the event, of its featuring parameter and of its probability, for instance the question is what is the flow rate of a flooding that has a probability of 10 -3 to happen, 2) to collect data over a long period of time (or to recover data from past periods), 3) to extract extreme values from the data, 4) to find an adequate statistical law that fits the spreading of the extreme values, 5) the selected statistical law must be validated through visual or statistical tests, and 6) the computation of the flow rate of the event itself. (A.C.)

  11. Feature Detection, Characterization and Confirmation Methodology: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Karasaki, Kenzi; Apps, John; Doughty, Christine; Gwatney, Hope; Onishi, Celia Tiemi; Trautz, Robert; Tsang, Chin-Fu

    2007-03-01

    This is the final report of the NUMO-LBNL collaborative project: Feature Detection, Characterization and Confirmation Methodology under NUMO-DOE/LBNL collaboration agreement, the task description of which can be found in the Appendix. We examine site characterization projects from several sites in the world. The list includes Yucca Mountain in the USA, Tono and Horonobe in Japan, AECL in Canada, sites in Sweden, and Olkiluoto in Finland. We identify important geologic features and parameters common to most (or all) sites to provide useful information for future repository siting activity. At first glance, one could question whether there was any commonality among the sites, which are in different rock types at different locations. For example, the planned Yucca Mountain site is a dry repository in unsaturated tuff, whereas the Swedish sites are situated in saturated granite. However, the study concludes that indeed there are a number of important common features and parameters among all the sites--namely, (1) fault properties, (2) fracture-matrix interaction (3) groundwater flux, (4) boundary conditions, and (5) the permeability and porosity of the materials. We list the lessons learned from the Yucca Mountain Project and other site characterization programs. Most programs have by and large been quite successful. Nonetheless, there are definitely 'should-haves' and 'could-haves', or lessons to be learned, in all these programs. Although each site characterization program has some unique aspects, we believe that these crosscutting lessons can be very useful for future site investigations to be conducted in Japan. One of the most common lessons learned is that a repository program should allow for flexibility, in both schedule and approach. We examine field investigation technologies used to collect site characterization data in the field. An extensive list of existing field technologies is presented, with some discussion on usage and limitations

  12. Feature Detection, Characterization and Confirmation Methodology: Final Report

    International Nuclear Information System (INIS)

    Karasaki, Kenzi; Apps, John; Doughty, Christine; Gwatney, Hope; Onishi, Celia Tiemi; Trautz, Robert; Tsang, Chin-Fu

    2007-01-01

    This is the final report of the NUMO-LBNL collaborative project: Feature Detection, Characterization and Confirmation Methodology under NUMO-DOE/LBNL collaboration agreement, the task description of which can be found in the Appendix. We examine site characterization projects from several sites in the world. The list includes Yucca Mountain in the USA, Tono and Horonobe in Japan, AECL in Canada, sites in Sweden, and Olkiluoto in Finland. We identify important geologic features and parameters common to most (or all) sites to provide useful information for future repository siting activity. At first glance, one could question whether there was any commonality among the sites, which are in different rock types at different locations. For example, the planned Yucca Mountain site is a dry repository in unsaturated tuff, whereas the Swedish sites are situated in saturated granite. However, the study concludes that indeed there are a number of important common features and parameters among all the sites--namely, (1) fault properties, (2) fracture-matrix interaction (3) groundwater flux, (4) boundary conditions, and (5) the permeability and porosity of the materials. We list the lessons learned from the Yucca Mountain Project and other site characterization programs. Most programs have by and large been quite successful. Nonetheless, there are definitely 'should-haves' and 'could-haves', or lessons to be learned, in all these programs. Although each site characterization program has some unique aspects, we believe that these crosscutting lessons can be very useful for future site investigations to be conducted in Japan. One of the most common lessons learned is that a repository program should allow for flexibility, in both schedule and approach. We examine field investigation technologies used to collect site characterization data in the field. An extensive list of existing field technologies is presented, with some discussion on usage and limitations. Many of the

  13. [Acromegaly features in the aging population].

    Science.gov (United States)

    Anoun, Nadia; El Ouahabi, Hanan

    2017-01-01

    Somatotroph adenomas are rare in the aging population. Diagnosis of somatotroph adenomas is often long delayed and they are characterized by atypical clinical picture. Their diagnostic criteria are similar to those used for younger patients. Surgery, if possible, is the treatment of choice for acromegaly in the elderly. Somatostatin analogues have shown to be effective in these patients. Prognosis is inversely correlated with patient's age, duration of disease and last GH level under treatment. Beside evolution of disease, age is a major determinant of mortality. We report three cases of elderly patients with acromegaly aged 75, 70 and 66 years respectively with a literature review.

  14. Notes on the evolution of feature selection methodology

    Czech Academy of Sciences Publication Activity Database

    Somol, Petr; Novovičová, Jana; Pudil, Pavel

    2007-01-01

    Roč. 43, č. 5 (2007), s. 713-730 ISSN 0023-5954 R&D Projects: GA ČR GA102/07/1594; GA MŠk 1M0572; GA AV ČR IAA2075302 EU Projects: European Commission(XE) 507752 - MUSCLE Grant - others:GA MŠk(CZ) 2C06019 Institutional research plan: CEZ:AV0Z10750506 Keywords : feature selection * branch and bound * sequential search * mixture model Subject RIV: IN - Informatics, Computer Science Impact factor: 0.552, year: 2007

  15. Psychological Features of Foreign Language Acquisition in Different Age Groups

    Directory of Open Access Journals (Sweden)

    N V Kudinova

    2011-06-01

    Full Text Available The influence of age factor on the foreign language learning is examined in the article from the practical point of view. The specific age features and their influence on the foreign language acquisition at different stages of age are highlighted and analyzed on the basis of psychological research.

  16. Registration-analytical maintenance and methodological features of construction of the financial account

    OpenAIRE

    Kraevskyy, V.

    2009-01-01

    In article registration-analytical maintenance and methodological features of construction of the financial account is considered. Financial account, net lending, net borrowing, financial assets, system of the national accounts.

  17. Park Planning for Ageing Adults Using Grounded Theory Methodology

    Directory of Open Access Journals (Sweden)

    Bernie Dahl

    2004-06-01

    Full Text Available The importance of understanding park planning issues and implementing planning strategies for ageing adults was the driving force for this study. Literature reviews have identified a variety of scholarly work from fields such as gerontology, psychology, sociology and economics, all of which provide valuable information regarding the special needs of ageing adults. Very few researchers, however, have investigated the leisure behaviours of older adults in outdoor recreation (Croskeys, Tinsley and Tinsley, 2002 and the use of grounded theory methodology has essentially been unexplored in this area. Ageing adults are projected to live more than 20 percent of their life in retirement (MRP, 1998, cited in Croskeys, Tinsley and Tinsley, 2002, allowing for an increased amount of discretionary time. This offers opportunities for ageing adults to participate in outdoor recreational activities and will undoubtedly increase their leisure time. However, with limited research in recreational needs and inclusion for older adults, it is difficult for park planners and administrators to meet the growing needs of this population. Therefore, this research is necessary in order to determine whether ageing adults are being accounted for in park and outdoor recreational planning. The objective of this study was to use grounded theory research methodology to identify and examine ageing adult needs in relation to outdoor leisure activities in a regional park setting. Ten Midwestern regional park visitors (aged 65-75 years old and four park employees were interviewed. Our research attempts to fill in the gaps between the perceptions of ageing park users and those of park planners, using a methodology that relies primarily on direct contact with park visitors.

  18. Methodological Features of Educational System Modernization in the Context of the "Economy of Knowledge"

    Science.gov (United States)

    Karpova, Natalia Konstantinovna; Uvarovsky, Alexander Pavlovich; Mareev, Vladimir Ivanovich; Petrova, Nina Petrovna; Borzilov, Yuri Petrovich

    2016-01-01

    The article is devoted to some methodological features of modernization in modern education in the context of "the knowledge economy" development which is aimed at shaping new mental potential of the modern state. Features and prerequisites for the emergence of the knowledge economy, the priorities of which include the development and…

  19. On the Quantification of Aging Effects on Biometric Features

    OpenAIRE

    Lanitis , Andreas; Tsapatsoulis , Nicolas

    2010-01-01

    International audience; Biometric templates are often used in intelligent human computer interaction systems that include automated access control and personalization of user interaction. The effectiveness of biometric systems is directly linked with aging that causes modifications on biometric features. For example the long term performance of person identification systems decreases as biometric templates derived from aged subjects may display substantial differences when compared to referen...

  20. Age Features Of Peptic And Duodenal Ulcer Disease

    Directory of Open Access Journals (Sweden)

    Е.А. Islamova

    2009-12-01

    Full Text Available Peptic ulcer disease is one of the most widespread diseases. 6-10 % of adult population in Russia suffer from it. Demographic processes in the Russian Federation determine the increase of patients' number aged over 60 with peptic ulcer disease. It counts 10-35 % of all patients with this disease. The modern views on pathogenesis of peptic ulcer disease, including factor of Helicobacter pylori, in patients of different age groups have been highlighted in the article. Pathogenetic features and clinical morphological manifestations of peptic ulcer disease in young and aged patients have been considered

  1. Methodology to analysis of aging processes of containment spray system

    International Nuclear Information System (INIS)

    Borges, D. da Silva; Lava, D.D.; Moreira, M. de L.; Ferreira Guimarães, A.C.; Fernandes da Silva, L.

    2015-01-01

    This paper presents a contribution to the study of aging process of components in commercial plants of Pressurized Water Reactors (PWRs). The motivation for write this work emerged from the current perspective nuclear. Numerous nuclear power plants worldwide have an advanced operating time. This problem requires a process to ensure the confiability of the operative systems of these plants, because of this, it is necessary a methodologies capable of estimate the failure probability of the components and systems. In addition to the safety factors involved, such methodologies can to be used to search ways to ensure the extension of the life cycle of nuclear plants, which inevitably will pass by the decommissioning process after the operating time of 40 years. This process negatively affects the power generation, besides demanding an enormous investment for such. Thus, this paper aims to present modeling techniques and sensitivity analysis, which together can generate an estimate of how components, which are more sensitive to the aging process, will behave during the normal operation cycle of a nuclear power plant. (authors)

  2. Hippocampal sclerosis in advanced age: clinical and pathological features.

    Science.gov (United States)

    Nelson, Peter T; Schmitt, Frederick A; Lin, Yushun; Abner, Erin L; Jicha, Gregory A; Patel, Ela; Thomason, Paula C; Neltner, Janna H; Smith, Charles D; Santacruz, Karen S; Sonnen, Joshua A; Poon, Leonard W; Gearing, Marla; Green, Robert C; Woodard, John L; Van Eldik, Linda J; Kryscio, Richard J

    2011-05-01

    Hippocampal sclerosis is a relatively common neuropathological finding (∼10% of individuals over the age of 85 years) characterized by cell loss and gliosis in the hippocampus that is not explained by Alzheimer's disease. Hippocampal sclerosis pathology can be associated with different underlying causes, and we refer to hippocampal sclerosis in the aged brain as hippocampal sclerosis associated with ageing. Much remains unknown about hippocampal sclerosis associated with ageing. We combined three different large autopsy cohorts: University of Kentucky Alzheimer's Disease Centre, the Nun Study and the Georgia Centenarian Study to obtain a pool of 1110 patients, all of whom were evaluated neuropathologically at the University of Kentucky. We focused on the subset of cases with neuropathology-confirmed hippocampal sclerosis (n=106). For individuals aged≥95 years at death (n=179 in our sample), each year of life beyond the age of 95 years correlated with increased prevalence of hippocampal sclerosis pathology and decreased prevalence of 'definite' Alzheimer's disease pathology. Aberrant TAR DNA protein 43 immunohistochemistry was seen in 89.9% of hippocampal sclerosis positive patients compared with 9.7% of hippocampal sclerosis negative patients. TAR DNA protein 43 immunohistochemistry can be used to demonstrate that the disease is usually bilateral even when hippocampal sclerosis pathology is not obvious by haematoxylin and eosin stains. TAR DNA protein 43 immunohistochemistry was negative on brain sections from younger individuals (n=10) after hippocampectomy due to seizures, who had pathologically confirmed hippocampal sclerosis. There was no association between cases with hippocampal sclerosis associated with ageing and apolipoprotein E genotype. Age of death and clinical features of hippocampal sclerosis associated with ageing (with or without aberrant TAR DNA protein 43) were distinct from previously published cases of frontotemporal lobar degeneration TAR

  3. License Application Design Selection Feature Report: Aging and Blending

    International Nuclear Information System (INIS)

    Coltoni, B.; Anderson, M.J.

    1999-01-01

    The purpose of this document is to evaluate the concepts of Aging and Blending for waste sent to the Monitored Geologic Repository (MGR). These design features are based on pre-emplacement treatment of the waste stream. The envelope of the analysis has been performed under the direction of the License Application Design Selection Team (LADST), which advocated utilizing the Viability Assessment (VA) repository design (DOE 1998c) as the basis. Therefore, this evaluation attempts to modify the VA design only to the extent that Aging and Blending can be accomplished. This modified VA design will be contrasted to the VA Design and the difference in design, costs, and performance will be presented

  4. Hippocampal sclerosis in advanced age: clinical and pathological features

    Science.gov (United States)

    Schmitt, Frederick A.; Lin, Yushun; Abner, Erin L.; Jicha, Gregory A.; Patel, Ela; Thomason, Paula C.; Neltner, Janna H.; Smith, Charles D.; Santacruz, Karen S.; Sonnen, Joshua A.; Poon, Leonard W.; Gearing, Marla; Green, Robert C.; Woodard, John L.; Van Eldik, Linda J.; Kryscio, Richard J.

    2011-01-01

    Hippocampal sclerosis is a relatively common neuropathological finding (∼10% of individuals over the age of 85 years) characterized by cell loss and gliosis in the hippocampus that is not explained by Alzheimer’s disease. Hippocampal sclerosis pathology can be associated with different underlying causes, and we refer to hippocampal sclerosis in the aged brain as hippocampal sclerosis associated with ageing. Much remains unknown about hippocampal sclerosis associated with ageing. We combined three different large autopsy cohorts: University of Kentucky Alzheimer’s Disease Centre, the Nun Study and the Georgia Centenarian Study to obtain a pool of 1110 patients, all of whom were evaluated neuropathologically at the University of Kentucky. We focused on the subset of cases with neuropathology-confirmed hippocampal sclerosis (n = 106). For individuals aged ≥95 years at death (n = 179 in our sample), each year of life beyond the age of 95 years correlated with increased prevalence of hippocampal sclerosis pathology and decreased prevalence of ‘definite’ Alzheimer’s disease pathology. Aberrant TAR DNA protein 43 immunohistochemistry was seen in 89.9% of hippocampal sclerosis positive patients compared with 9.7% of hippocampal sclerosis negative patients. TAR DNA protein 43 immunohistochemistry can be used to demonstrate that the disease is usually bilateral even when hippocampal sclerosis pathology is not obvious by haematoxylin and eosin stains. TAR DNA protein 43 immunohistochemistry was negative on brain sections from younger individuals (n = 10) after hippocampectomy due to seizures, who had pathologically confirmed hippocampal sclerosis. There was no association between cases with hippocampal sclerosis associated with ageing and apolipoprotein E genotype. Age of death and clinical features of hippocampal sclerosis associated with ageing (with or without aberrant TAR DNA protein 43) were distinct from previously published cases of frontotemporal lobar

  5. Age-related distance esotropia: Clinical features and therapeutic outcomes.

    Science.gov (United States)

    Gómez de Liaño Sánchez, P; Olavarri González, G; Merino Sanz, P; Escribano Villafruela, J C

    2016-12-01

    To describe the clinical characteristics and surgical outcomes of a group of patients with age-related distance esotropia (ARDE). A retrospective study was conducted on a consecutive case series of 16 adult patients diagnosed with ARDE between 2008 and 2015. The clinical features evaluated included mean age and gender, primary position deviations at distance and near, measured in prism dioptres (pd), treatment offered in each case, and post-surgical deviations. Ductions and versions were full, with no evidence of lateral rectus paresis. None of these patients had any obvious underlying neurological disorder, such as, high myopia or thyroid disease. A good result is considered to be the disappearance of diplopia in all positions of gaze. A total of 16 patients (11 females [68.8%]) were identified. The mean age at diagnosis was 78.19±6.77 years. The mean initial esodeviation was 2.25±3.08 pd at near (-4 to +8 pd) and 9.5±4.18 pd at distance (2 to 18 pd). Treatment was not necessary in 5 cases because the symptoms were intermittent or well-tolerated. Of the 11 patients with symptoms, one was corrected with an external base therapeutic prism. Botulinum toxin was administered in another patient, without satisfactory results. Unilateral medial rectus muscle recession was performed on one patient, and unilateral lateral rectus plication on 7 patients, indicating prisms before surgery. One patient refused surgery despite continuous diplopia in far vision. After a mean follow-up of 16.5 months, all operated patients were asymptomatic. Not all patients with ARDE require treatment, as the tolerance to diplopia varies from one subject to another. Both medial rectus weakening and lateral rectus strengthening provides excellent results. Crown Copyright © 2016. Publicado por Elsevier España, S.L.U. All rights reserved.

  6. Artificial Neural Networks and Gene Expression Programing based age estimation using facial features

    Directory of Open Access Journals (Sweden)

    Baddrud Z. Laskar

    2015-10-01

    Full Text Available This work is about estimating human age automatically through analysis of facial images. It has got a lot of real-world applications. Due to prompt advances in the fields of machine vision, facial image processing, and computer graphics, automatic age estimation via faces in computer is one of the dominant topics these days. This is due to widespread real-world applications, in areas of biometrics, security, surveillance, control, forensic art, entertainment, online customer management and support, along with cosmetology. As it is difficult to estimate the exact age, this system is to estimate a certain range of ages. Four sets of classifications have been used to differentiate a person’s data into one of the different age groups. The uniqueness about this study is the usage of two technologies i.e., Artificial Neural Networks (ANN and Gene Expression Programing (GEP to estimate the age and then compare the results. New methodologies like Gene Expression Programing (GEP have been explored here and significant results were found. The dataset has been developed to provide more efficient results by superior preprocessing methods. This proposed approach has been developed, tested and trained using both the methods. A public data set was used to test the system, FG-NET. The quality of the proposed system for age estimation using facial features is shown by broad experiments on the available database of FG-NET.

  7. Effects of Normal Aging on Memory for Multiple Contextual Features

    Science.gov (United States)

    Gagnon, Sylvain; Soulard, Kathleen; Brasgold, Melissa; Kreller, Joshua

    2007-01-01

    Twenty-four younger (18-35 years) and 24 older adult participants (65 or older) were exposed to three experimental conditions involving the memorization words and their associated contextual features, with contextual feature complexity increasing from Conditions 1 to 3. In Condition 1, words presented varied only on one binary feature (color,…

  8. Aging Methodologies and Prognostic Health Management for Electrolytic Capacitors

    Data.gov (United States)

    National Aeronautics and Space Administration — Understanding the ageing mechanisms of electronic components critical avionics systems such as the GPS and INAV are of critical importance. Electrolytic capacitors...

  9. A methodology for texture feature-based quality assessment in nucleus segmentation of histopathology image

    Directory of Open Access Journals (Sweden)

    Si Wen

    2017-01-01

    Full Text Available Context: Image segmentation pipelines often are sensitive to algorithm input parameters. Algorithm parameters optimized for a set of images do not necessarily produce good-quality-segmentation results for other images. Even within an image, some regions may not be well segmented due to a number of factors, including multiple pieces of tissue with distinct characteristics, differences in staining of the tissue, normal versus tumor regions, and tumor heterogeneity. Evaluation of quality of segmentation results is an important step in image analysis. It is very labor intensive to do quality assessment manually with large image datasets because a whole-slide tissue image may have hundreds of thousands of nuclei. Semi-automatic mechanisms are needed to assist researchers and application developers to detect image regions with bad segmentations efficiently. Aims: Our goal is to develop and evaluate a machine-learning-based semi-automated workflow to assess quality of nucleus segmentation results in a large set of whole-slide tissue images. Methods: We propose a quality control methodology, in which machine-learning algorithms are trained with image intensity and texture features to produce a classification model. This model is applied to image patches in a whole-slide tissue image to predict the quality of nucleus segmentation in each patch. The training step of our methodology involves the selection and labeling of regions by a pathologist in a set of images to create the training dataset. The image regions are partitioned into patches. A set of intensity and texture features is computed for each patch. A classifier is trained with the features and the labels assigned by the pathologist. At the end of this process, a classification model is generated. The classification step applies the classification model to unlabeled test images. Each test image is partitioned into patches. The classification model is applied to each patch to predict the patch

  10. SAFETY ANALYSIS METHODOLOGY FOR AGED CANDU® 6 NUCLEAR REACTORS

    Directory of Open Access Journals (Sweden)

    WOLFGANG HARTMANN

    2013-10-01

    Full Text Available This paper deals with the Safety Analysis for CANDU® 6 nuclear reactors as affected by main Heat Transport System (HTS aging. Operational and aging related changes of the HTS throughout its lifetime may lead to restrictions in certain safety system settings and hence some restriction in performance under certain conditions. A step in confirming safe reactor operation is the tracking of relevant data and their corresponding interpretation by the use of appropriate thermalhydraulic analytic models. Safety analyses ranging from the assessment of safety limits associated with the prevention of intermittent fuel sheath dryout for a slow Loss of Regulation (LOR analysis and fission gas release after a fuel failure are summarized. Specifically for fission gas release, the thermalhydraulic analysis for a fresh core and an 11 Effective Full Power Years (EFPY aged core was summarized, leading to the most severe stagnation break sizes for the inlet feeder break and the channel failure time. Associated coolant conditions provide the input data for fuel analyses. Based on the thermalhydraulic data, the fission product inventory under normal operating conditions may be calculated for both fresh and aged cores, and the fission gas release may be evaluated during the transient. This analysis plays a major role in determining possible radiation doses to the public after postulated accidents have occurred.

  11. Aging evaluation methodology of periodic safety review in Korea

    International Nuclear Information System (INIS)

    Park, Heung-Bae; Jung, Sung-Gyu; Jin, Tae-Eun; Jeong, Ill-Seok

    2002-01-01

    In Korea plant lifetime management (PLIM) study for Kori Unit 1 has been performed since 1993. Meanwhile, periodic safety review (PSR) for all operating nuclear power plants (NPPs) has been started with Kori Unit 1 since 2000 per IAEA recommendation. The evaluation period is 10 years, and safety (evaluation) factors are 11 per IAEA guidelines as represented in table 1. The relationship between PSR factors and PLIM is also represented. Among these factors evaluation of 'management of aging' is one of the most important and difficult factor. This factor is related to 'actual condition of the NPP', 'use of experience from other nuclear NPPs and of research findings', and 'management of aging'. The object of 'management of aging' is to obtain plant safety through identifying actual condition of system, structure and components (SSCs) and evaluating aging phenomena and residual life of SSCs using operating experience and research findings. The paper describes the scope and procedure of valuation of 'management of aging', such as, screening criteria of SSCs, Code and Standards, evaluation of SSCs and safety issues as represented. Evaluating SSCs are determined using final safety analysis report (FSAR) and power unit maintenance system for Nuclear Ver. III (PUMAS/N-III). The screening criteria of SSCs are safety-related items (quality class Q), safety-impact items (quality class T), backfitting rule items (fire protection (10CFR50.48), environmental qualification (10CFR50.49), pressurized thermal shock (10CFR50.61), anticipated transient without scram (10CFR50.62), and station blackout (10CFR50.63)) and regulating authority requiring items[1∼3]. The purpose of review of Code and Standards is identifying actual condition of the NPP and evaluating aging management using effective Code and Standards corresponding to reactor facilities. Code and Standards is composed of regulating laws, FSAR items, administrative actions, regulating actions, agreement items, and other

  12. The study of evaluation methodology of the aging and degradation researches

    International Nuclear Information System (INIS)

    Cho, C. J.; Park, Z. H.; Jeong, I. S.

    2001-01-01

    To judge the usefulness of aging related researches like PLIM (Plant lifetime Management) and aging related degradation, et. al. in PSR(Periodic Safety Review), the evaluation methodology of the R and D have been proposed up to now are reviewed. The infometric methodology is considered to be the optimum method for the evaluation of the nuclear related researches. And finally, to increase the objectiveness and reliability of the infometric methodology in the aging and degradation researches, the indexes of safety, technology and economics are introduced. From this study, the infometric methodology has the advantage of the actual engineering evaluation in the nuclear related researches with other methodologies, but for the further research, the effective construction of DB and survey of various statistics in the technical reports and papers are needed

  13. Tourette Syndrome and Associated Features and the School Aged Child.

    Science.gov (United States)

    Willis, Christopher

    Tourette Syndrome (TS) is described as a genetically based, chronic constellation of neurobehavioral symptoms and associated features involving repetitive, simple, and/or complex motor and phonic tics. Treatment generally involves neuroleptic medication. Symptoms of obsessive-compulsive disorder, attention deficit hyperactive disorder, learning…

  14. Methodologies for Active Aging in the Manufacturing Sector

    Science.gov (United States)

    Fornasiero, Rosanna; Berdicchia, Domenica; Zambelli, Mario; Masino, Giovanni

    The research project named “Flexibly Beyond” studied and experimented innovative models for the enhancement of the role of senior workers and prolongation of their working life. The research was based on the application of innovative methods and tools to the ageing society and in particular to the European manufacturing companies represented in the project by apparel and footwear sectors. The project was funded under the Innovative Measures of the art.6 of the European Social Fund (VS/2006/0353) and coordinated by Politecnico Calzaturiero. The real strength of the project was the large network including all the actors of the value chain which allows transferring the theoretical findings to practical level in SMEs manufacturing context.

  15. Personality and Total Health Through Life Project Eye Substudy: Methodology and Baseline Retinal Features.

    Science.gov (United States)

    Wijngaarden, Peter Van; Keel, Stuart; Hodgson, Lauren A B; Kumar, Dinesh K; Aliahmad, Behzad; Paim, Cistiane C; Kiely, Kim M; Cherbuin, Nicolas; Anstey, Kaarin J; Dirani, Mohamed

    2017-01-01

    To describe the methodology and present the retinal grading findings of an older sample of australians with well-defined indices of neurocognitive function in the Personality and total Health (PATH) through life project. A cross-sectional study. Three hundred twenty-six individuals from the PatH through life project were invited to participate. Participants completed a general questionnaire and 2-field, 45-degree nonmydriatic color digital retinal photography. Photographs were graded for retinal pathology according to established protocols. Two hundred fifty-four (77.9%) subjects, aged 72 to 78 years, agreed to participate in the eye substudy. gradable images of at least 1 eye were acquired in 211 of 254 subjects (83.1%). retinal photographic screening identified 1 or more signs of pathology in 130 of the 174 subjects (74.7%) with gradable images of both eyes. a total of 45 participants (17.7%) had self-reported diabetes and diabetic retinopathy was observed in 22 (48.9%) of these participants. This well-defined sample of older australians provides a unique opportunity to interrogate associations between retinal findings, including retinal vascular geometric parameters, and indices of neurocognitive function. Copyright 2017 Asia-Pacific Academy of Ophthalmology.

  16. Age-related features of renal function (on radiorenographic data)

    International Nuclear Information System (INIS)

    Korkushko, O.V.; Frajfel'd, V.Eh.; Belyj, A.A.

    1986-01-01

    Renal function of 91 healthy subjects aged 18-91 has been evaluated at radionuclide renography with the use of 131 I-Hippuran. Renal excretory function, effective renal plasma and blood flows were found to decrease annually by 0.09 ml/kg in ageing men and by 0.08 ml/kg in women. The use of new indices may be useful for evaluation of renal blood circulation, especially during hypo- or hypervolaemia is proposed. These are the index of renal circulation efficiency and the mean time of circulating blood volume transfer through renal blood vessels

  17. AGE-DEPENDENT FEATURES OF EVOLVING HUMORAL IMMUNITY IN CHILDREN

    Directory of Open Access Journals (Sweden)

    A. P. Toptygina

    2012-01-01

    Full Text Available Abstract. Age dynamics of humoral immunity was studied in healthy children, i.e., 11 newborns, 33 infants of 4 to 8 months, 32 children of 1 to 2 years old,, 17 children of 4 to 5 years old, 25 children of 6 to 8 years old, 15 children of 9 to 11 years old, and 28 adolescents of 14 to 16 years old. Evaluation of membrane receptors on B cells was performed by means of three-colour fluorescent label and allowed of characterizing B1 subpopulations (CD19+CD5+CD27-, naпve B2 cells (CD19+CD5-CD27-, and B2 memory cells (CD19+CD5-CD27+. B1 cells have been shown to dominate in blood of newborns and younger children (up to 5 years old. By the contrary, B2 memory cells were nearly undetectable in newborns, and exceeded 20% in adolescents (by 15 years old. Meanwhile, it has been revealed that the amounts of IgG1 and IgG3 subclasses did progressively increase with age, whereas IgG2 remained decreased to 50% of adult values for a long time, and reached them by 11 years and later. We suggest that the age dynamics of IgG subclasses is connected with age-dependent changes in B cell subpopulations.

  18. Gluten Intolerance: Sex- and Age-Related Features

    Directory of Open Access Journals (Sweden)

    MJ Llorente-Alonso

    2006-01-01

    Full Text Available OBJECTIVE: Gluten intolerance is an immune-mediated enteropathy associated with gluten-containing foods in genetically susceptible patients. The typical form mainly affecting children shows failure to thrive and/or gastrointestinal symptoms. The adult form is less typical, presenting vague gastrointestinal symptoms, iron deficiency (with or without anemia or nonspecific serum chemistry abnormalities. The present study aims to analyze clinical and biochemical differences of celiac disease (CD according to sex and age.

  19. Features of Chronic Bronchitis in Different Age Groups

    Directory of Open Access Journals (Sweden)

    Galina L. Ignatova

    2014-03-01

    Full Text Available Background: Lung diseases are assuming greater relevance and importance today. Chronic bronchitis is a self-nosology, which may precede the development of COPD, the importance of which can hardly be overestimated. The main problem in this disease is caused by late diagnosis and treatment due to the delay by patients in seeking medical help. The aim of the work was to study the distribution and exposure to tobacco smoke, especially chronic bronchitis, depending on various factors, including age. Methods: We examined 1779 persons, including 855 men and 924 women. The mean age of the population was 35.83±8.3 years. We conducted surveys and spirometry. The outcome was assessed after a bronchodilation test was performed with salbutamol 400 mcg. We performed all statistical analysis using software package Statistica 10. Results: We identified chronic bronchitis in 9.2% of the cases in the group of younger individuals and in 14.9% of the cases in the group of older individuals, during the active detection of chronic bronchitis using questionnaires. The prevalence of cigarette smoking was slightly higher among the younger (39.5% than the older persons (33.6%; the frequency of smoking in a group of chronic bronchitis was reliably higher. Also, in this group, the performance spirometry reliably decreased. Conclusions: Outpatient survey is an effective method of identifying chronic bronchitis. Smoking is a major risk factor in the group of young respondents and the prevalence of smoking is inversely related to the education level of the respondents, regardless of age. As the decline in the Forced Expiratory Volume (FEV1 and FEV1/FVC is the main criterion diagnosis of COPD, it revealed significant declines in the FEV1 of the younger smoking individuals, which may help to predict the development of COPD in the older age group.

  20. Features of gas exchange of healthy people of working age

    OpenAIRE

    Noreiko S.B.

    2011-01-01

    The purpose of this study was to improve the accuracy of determining the basal metabolism of healthy people. Comparative studies of basal metabolism of healthy men and women on probation and respiratory physical factors are considered. Surveyed 30 healthy men and women aged 21-56 years. Determination of the volume of absorbed oxygen and produces carbon dioxide carried by the gas analyzer "Spirolit-2" were defined. Calculate the actual respiratory rate. It is established that the actual value ...

  1. Unique features of creative designing at the preschool age

    Directory of Open Access Journals (Sweden)

    Bilа Iryna Mykolayivna

    2017-04-01

    Full Text Available The research is devoted to studying the specificity of creative designing at the preschool age. The author identifies the systematic approach on the design work and creative designing, knowledge adjustment, as well as the assessment criteria and performance indicators of creative designing by children at the preschool age. The article considers the psychological structure of the design activity, clarifies its characteristics and defines the role of each component of creative designing process at the preschool age. As a result of the empirical study it was proved that in the process of understanding the challenges pre-schoolers’s mind makes mental acts of comparison predominant. Their creative intention is determined by the focus on the structural and structural-functional characteristics of the subjects. The whole structure of the pre-schooler’s solution in the process of working with creative tasks on designing is integrated with the individual and regulatory aspect of creative designing that appears in the subjective mental actions, trends, and practice.

  2. Age Differences in Attention Lapses Mask Age Differences in Memory Failures: A Methodological Note on Suppression

    OpenAIRE

    James Allan Cheyne; Jonathan S. A. Carriere; Dan eSmilek

    2013-01-01

    Although objective measures of memory performance typically indicate memory declines with age, self-reported memory failures often show no relation to age. In contrast, self-reported attention failures are reliably negatively correlated with age. This contrast suggests the possibility that age-related awareness and reporting of memory failures might be masked by a concurrent decrease in attention failures, which would reduce encoding failures with age and hence reduce perceived memory failure...

  3. Microstructural Features in Corroded Celtic Iron Age Sword Blades

    Science.gov (United States)

    Ghiara, G.; Piccardo, P.; Campodonico, S.; Carnasciali, M. M.

    2014-05-01

    Archaeological artefacts made from iron and steel are often of critical importance for archaeometallurgical studies, which aim to understand the process of manufacturing, as the nearly complete alloy mineralization does not allow for any type of metallographic interpretation. In this study, three Iron Age sword blades dated from the second century BC (LaTène B2/D1) found in the archaeological site of Tintignac (Commune de Naves, Corrèze, France), were investigated. A multianalytical approach was employed to acquire a complete range of data from the partially or totally corroded objects. Analyses were carried out with the use of light optical microscopy, micro Raman spectroscopy, and scanning electron microscopy equipped with energy-dispersive x-ray spectroscopy (EDXS). Remnants of metallographic features—ghost microstructure—in the corrosion layers of the blades were observed, allowing for a partial reconstruction of the manufacturing process.

  4. A reverse engineering methodology for nickel alloy turbine blades with internal features

    DEFF Research Database (Denmark)

    Gameros, A.; De Chiffre, Leonardo; Siller, H.R.

    2015-01-01

    The scope of this work is to present a reverse engineering (RE) methodology for freeform surfaces, based on a case study of a turbine blade made of Inconel, including the reconstruction of its internal cooling system. The methodology uses an optical scanner and X-ray computed tomography (CT......) equipment. Traceability of the measurements was obtained through the use of a Modular Freeform Gage (MFG). An uncertainty budget is presented for both measuring technologies and results show that the RE methodology presented is promising when comparing uncertainty values against common industrial tolerances....

  5. METHODOLOGICAL FEATURES OF HISTORICAL TYPES OF ECONOMIC THEORY'S SCIENTIFIC RATIONALITY IN TERMS OF MODERN PHILOSOPHY OF SCIENCE

    Directory of Open Access Journals (Sweden)

    T. Gaidai

    2015-10-01

    Full Text Available The article studies the evolution of basic methodological features of economic theory on its different historical stages.The research highlights the fruitful usage of a new analytical approach on the basis of the achievements of modern philosophy of science. Its presents the research of main types of scientific rationality dominating at certain historical stages of science maturity. Such as historical, classical, nonclassical and postnonclassical types of scientific rationality. Structuring and research of basic methodological features of such historical types of economic theory’s scientific rationality as classical economics (end of ХVII century – 70-th of XIX century, nonclassical economics (70-th of ХІХ century – 70-th of ХХ century, postnonclassical economics (70-th of ХХст. – the beginning of ХХI century are undertaken. Methodological analysis accentuated ideological, ontological, epistemological dominants and main differences in basic techniques of the main types of economic theory’s scientific rationality. The research argues the illegality of existing in the economics literature attempts to identification or simplified reduction of more mature types of scientific rationality to the less mature. The article shows the contribution made by the leaders of classical, nonclassical and postnonclassical economics in the development of normative and positive economic methodology. It is emphasized a general tendency to methodological pluralism, pluralism of paradigmal structureand interdisciplinary of scientific economic knowledge throughout its historical development.

  6. Current status and future expectation concerning probabilistic risk assessment of NPPs. 1. Features and issues of probabilistic risk assessment methodology

    International Nuclear Information System (INIS)

    Yamashita, Masahiro

    2012-01-01

    Probabilistic risk assessment (PRA) of Nuclear Power Plants (NPPs) could play an important role in assuring safety of NPPs. However PRA had not always effectively used, which was indicated in Japanese government's report on Fukushima Daiichi NPP accident. At the Risk Technical Committee (RTC) of Standards Committee of Atomic Energy Society of Japan, preparation of standards (implementing criteria) focusing on PRA methodology and investigation on basic philosophy for use of PRA had been in progress. Based on activities of RTC, a serial in three articles including this described current status and future expectation concerning probabilistic risk assessment of NPPs. This article introduced features and issues of PRA methodology related to the use of PRA. Features of PRA methodology could be shown as (1) systematic and comprehensive understanding of risk, (2) support of grading approach, (3) identification of effective safety upgrade measures and (4) quantitative understanding of effects of uncertainty. Issues of PRA methodology were (1) extension of PRA application area, (2) upgrade of PRA methodology, (3) quality assurance of PRA, (4) treatment of uncertainty and (5) quantitative evaluation criteria. (T. Tanaka)

  7. A Bayesian Approach to Multistage Fitting of the Variation of the Skeletal Age Features

    Directory of Open Access Journals (Sweden)

    Dong Hua

    2009-01-01

    Full Text Available Accurate assessment of skeletal maturity is important clinically. Skeletal age assessment is usually based on features encoded in ossification centers. Therefore, it is critical to design a mechanism to capture as much as possible characteristics of features. We have observed that given a feature, there exist stages of the skeletal age such that the variation pattern of the feature differs in these stages. Based on this observation, we propose a Bayesian cut fitting to describe features in response to the skeletal age. With our approach, appropriate positions for stage separation are determined automatically by a Bayesian approach, and a model is used to fit the variation of a feature within each stage. Our experimental results show that the proposed method surpasses the traditional fitting using only one line or one curve not only in the efficiency and accuracy of fitting but also in global and local feature characterization.

  8. Features of gender identity among schoolchildren of different ages

    Directory of Open Access Journals (Sweden)

    O.Y. Marchenko

    2014-01-01

    Full Text Available Purpose . Gender identity manifestations in schoolchildren were investigated. Material . The study involved schoolchildren of 3 -11th forms of the secondary schools (206 – boys, 213 - girls. For the research of age peculiarities in psychological gender, a questioner worked out by Sundry Bam which consists of 60 statements was used. Results . A number of aspects of self description which have different psychological characteristics in boys and girls were analysed. A peculiarity of gender identity in schoolchildren, which was identified by the overall number of respondents in whom the androgens personality type was identified, was singled out. Out of 206 boys – 90% have an androgens index, as for the girls – 69.5% refer to androgens personality type. The presence of feminine character qualities in boys and masculine – in girls was found out, which proves maximal development of feminine and masculine in one person. This will help social adaptation of schoolchildren. Conclusions . Physical education has enormous potential emotional and physical impact on the formation of gender identity of students and their notions of femininity and masculinity. This can directly affect the formation of life value orientations students in general, including the formation of values in the sphere of physical culture.

  9. A data-driven multi-model methodology with deep feature selection for short-term wind forecasting

    International Nuclear Information System (INIS)

    Feng, Cong; Cui, Mingjian; Hodge, Bri-Mathias; Zhang, Jie

    2017-01-01

    Highlights: • An ensemble model is developed to produce both deterministic and probabilistic wind forecasts. • A deep feature selection framework is developed to optimally determine the inputs to the forecasting methodology. • The developed ensemble methodology has improved the forecasting accuracy by up to 30%. - Abstract: With the growing wind penetration into the power system worldwide, improving wind power forecasting accuracy is becoming increasingly important to ensure continued economic and reliable power system operations. In this paper, a data-driven multi-model wind forecasting methodology is developed with a two-layer ensemble machine learning technique. The first layer is composed of multiple machine learning models that generate individual forecasts. A deep feature selection framework is developed to determine the most suitable inputs to the first layer machine learning models. Then, a blending algorithm is applied in the second layer to create an ensemble of the forecasts produced by first layer models and generate both deterministic and probabilistic forecasts. This two-layer model seeks to utilize the statistically different characteristics of each machine learning algorithm. A number of machine learning algorithms are selected and compared in both layers. This developed multi-model wind forecasting methodology is compared to several benchmarks. The effectiveness of the proposed methodology is evaluated to provide 1-hour-ahead wind speed forecasting at seven locations of the Surface Radiation network. Numerical results show that comparing to the single-algorithm models, the developed multi-model framework with deep feature selection procedure has improved the forecasting accuracy by up to 30%.

  10. Features of the methodological approach to the evaluation of the led ...

    African Journals Online (AJOL)

    This article considers the issues related to research on the LED lighting efficiency in the industrial premises, the need to use the methodology to obtain meaningful scientific results. The LED lighting efficiency should be determined, primarily, based on the creation of conditions that are optimal for visual activity and safe from ...

  11. Methodology features and problems of definition of the term «green business»

    OpenAIRE

    Stepanenko, Bohdana

    2010-01-01

    The term «green business» is defined. Theoretical and methodological principles of functioning of this type of activity are reflected. Basic aspects and main development stages of green business are marked out. The classification of green business enterprise is shown.

  12. Predicting age groups of Twitter users based on language and metadata features.

    Directory of Open Access Journals (Sweden)

    Antonio A Morgan-Lopez

    Full Text Available Health organizations are increasingly using social media, such as Twitter, to disseminate health messages to target audiences. Determining the extent to which the target audience (e.g., age groups was reached is critical to evaluating the impact of social media education campaigns. The main objective of this study was to examine the separate and joint predictive validity of linguistic and metadata features in predicting the age of Twitter users. We created a labeled dataset of Twitter users across different age groups (youth, young adults, adults by collecting publicly available birthday announcement tweets using the Twitter Search application programming interface. We manually reviewed results and, for each age-labeled handle, collected the 200 most recent publicly available tweets and user handles' metadata. The labeled data were split into training and test datasets. We created separate models to examine the predictive validity of language features only, metadata features only, language and metadata features, and words/phrases from another age-validated dataset. We estimated accuracy, precision, recall, and F1 metrics for each model. An L1-regularized logistic regression model was conducted for each age group, and predicted probabilities between the training and test sets were compared for each age group. Cohen's d effect sizes were calculated to examine the relative importance of significant features. Models containing both Tweet language features and metadata features performed the best (74% precision, 74% recall, 74% F1 while the model containing only Twitter metadata features were least accurate (58% precision, 60% recall, and 57% F1 score. Top predictive features included use of terms such as "school" for youth and "college" for young adults. Overall, it was more challenging to predict older adults accurately. These results suggest that examining linguistic and Twitter metadata features to predict youth and young adult Twitter users may

  13. Relationships between abstract features and methodological quality explained variations of social media activity derived from systematic reviews about psoriasis interventions.

    Science.gov (United States)

    Ruano, J; Aguilar-Luque, M; Isla-Tejera, B; Alcalde-Mellado, P; Gay-Mimbrera, J; Hernandez-Romero, José Luis; Sanz-Cabanillas, J L; Maestre-López, B; González-Padilla, M; Carmona-Fernández, P J; Gómez-García, F; García-Nieto, A Vélez

    2018-05-24

    The aim of this study was to describe the relationship among abstract structure, readability, and completeness, and how these features may influence social media activity and bibliometric results, considering systematic reviews (SRs) about interventions in psoriasis classified by methodological quality. Systematic literature searches about psoriasis interventions were undertaken on relevant databases. For each review, methodological quality was evaluated using the Assessing the Methodological Quality of Systematic Reviews (AMSTAR) tool. Abstract extension, structure, readability, and quality and completeness of reporting were analyzed. Social media activity, which consider Twitter and Facebook mention counts, as well as Mendeley readers and Google scholar citations were obtained for each article. Analyses were conducted to describe any potential influence of abstract characteristics on review's social media diffusion. We classified 139 intervention SRs as displaying high/moderate/low methodological quality. We observed that abstract readability of SRs has been maintained high for last 20 years, although there are some differences based on their methodological quality. Free-format abstracts were most sensitive to the increase of text readability as compared with more structured abstracts (IMRAD or 8-headings), yielding opposite effects on their quality and completeness depending on the methodological quality: a worsening in low quality reviews and an improvement in those of high-quality. Both readability indices and PRISMA for Abstract total scores showed an inverse relationship with social media activity and bibliometric results in high methodological quality reviews but not in those of lower quality. Our results suggest that increasing abstract readability must be specially considered when writing free-format summaries of high-quality reviews, because this fact correlates with an improvement of their completeness and quality, and this may help to achieve broader

  14. [The system theory of aging: methodological principles, basic tenets and applications].

    Science.gov (United States)

    Krut'ko, V N; Dontsov, V I; Zakhar'iashcheva, O V

    2009-01-01

    The paper deals with the system theory of aging constructed on the basis of present-day scientific methodology--the system approach. The fundamental cause for aging is discrete existence of individual life forms, i.e. living organisms which, from the thermodynamic point of view, are not completely open systems. The primary aging process (build-up of chaos and system disintegration of aging organism) obeys the second law of thermodynamics or the law of entropy increase in individual partly open systems. In living organisms the law is exhibited as synergy of four main aging mechanisms: system "pollution" of organism, loss of non-regenerative elements, accumulation of damages and deformations, generation of variability on all levels, and negative changes in regulation processes and consequent degradation of the organism systematic character. These are the general aging mechanisms; however, the regulatory mechanisms may be important equally for organism aging and search for ways to prolong active life.

  15. The methodological features of managing the value of companies introducing "green" innovations

    Directory of Open Access Journals (Sweden)

    Kharin Alexander

    2012-03-01

    Full Text Available Although it is a common assumption that innovations are one of the most important factors of economic development, there is a need to review some provisions of innovation methodology so that new fundamental values are taken into account more fully. Most recent business models are based on the depletion of natural environment, whose potential has been almost exhausted. It is necessary to introduce new ideas that are of use for society and create values for companies. One way of achieving this goal is “green” (environmental innovations. The next decade is expected to see a rapid growth in environmental innovations. Their organization and management will require modern — and adequate to the objectives set —technologies. One of those is the quest for value methodology. To date, the quest for value methodology has given rise to several conceptual approaches, which can be used to evaluate the effectiveness of environmental innovations. This article discusses the advantages and disadvantages of major approaches. The author comes to a conclusion that that the modern theory and practice of corporate finance still lacks a generally accepted approach to assessing the value of companies that explicitly takes into account the impact of environmental factors on the cost. The article outlines the basic theoretical frameworks for the formation of such approach.

  16. Effect of sex, age, and breed on genetic recombination features in cattle

    Science.gov (United States)

    Meiotic recombination is a fundamental biological process which generates genetic diversity, affects fertility, and influences evolvability. Here we investigate the roles of sex, age, and breed in cattle recombination features, including recombination rate, location and crossover interference. Usin...

  17. Age-related X-ray feature of the spine in patients with achondroplasia

    International Nuclear Information System (INIS)

    Shevtsov, V.I.; D'yachkova, G.V.; Novikova, O.S.

    1999-01-01

    Age-related X-ray features of the spine in patients with achondroplasia are studied. It gives the time course of changes in the shape of vertebrae, the specific features of apophyseal ossification, provides a quantitative account of the shorter caudal lumbar vertebral arch root distance symptom. The time course of changes in the size of the lumbosacral angle was examined. The findings suggest that there are not only considerable static changes in the spine of patients with achondroplasia, but also significant age-related features of vertebral tissue growth and differentiation [ru

  18. Evaluation Methodology between Globalization and Localization Features Approaches for Skin Cancer Lesions Classification

    Science.gov (United States)

    Ahmed, H. M.; Al-azawi, R. J.; Abdulhameed, A. A.

    2018-05-01

    Huge efforts have been put in the developing of diagnostic methods to skin cancer disease. In this paper, two different approaches have been addressed for detection the skin cancer in dermoscopy images. The first approach uses a global method that uses global features for classifying skin lesions, whereas the second approach uses a local method that uses local features for classifying skin lesions. The aim of this paper is selecting the best approach for skin lesion classification. The dataset has been used in this paper consist of 200 dermoscopy images from Pedro Hispano Hospital (PH2). The achieved results are; sensitivity about 96%, specificity about 100%, precision about 100%, and accuracy about 97% for globalization approach while, sensitivity about 100%, specificity about 100%, precision about 100%, and accuracy about 100% for Localization Approach, these results showed that the localization approach achieved acceptable accuracy and better than globalization approach for skin cancer lesions classification.

  19. Cosmic ray exposure ages of features and events at the Apollo landing sites

    International Nuclear Information System (INIS)

    Arvidson, R.; Crozaz, G.; Drozd, R.J.; Hohenberg, C.M.; Morgan, C.J.

    1975-01-01

    Cosmic ray exposure ages of lunar samples have been used to date surface features related to impact cratering and downslope movement of material. Only when multiple samples related to a feature have the same rare gas exposure age, or when a single sample has the same 81 Kr-Kr and track exposure age can a feature be considered reliably dated. Because any single lunar sample is likely to have had a complex history, assignment of ages to features based upon only one determination by any method should be avoided. Based on the above criteria, there are only five well-dated lunar features: Cone Crater (Apollo 14) 26 m.y., North Ray Crater (Apollo 16) 50 m.y., South Ray Crater (Apollo 16) 2 m.y., the emplacement of the Station 6 boulders (Apollo 17) 22 m.y., and the emplacement of the Station 7 boulder (Apollo 17) 28 m.y. Other features are tentatively dated or have limits set on their ages: Bench Crater (Apollo 12) =50 m.y. (Auth.)

  20. Thermal aging of some decommissioned reactor components and methodology for life prediction

    International Nuclear Information System (INIS)

    Chung, H.M.

    1989-03-01

    Since a realistic aging of cast stainless steel components for end-of-life or life-extension conditions cannot be produced, it is customary to simulate the thermal aging embrittlement by accelerated aging at ∼400 degree C. In this investigation, field components obtained from decommissioned reactors have been examined after service up to 22 yr to provide a benchmark of the laboratory simulation. The primary and secondary aging processes were found to be identical to those of the laboratory-aged specimens, and the kinetic characteristics were also similar. The extent of the aging embrittlement processes and other key factors that are known to influence the embrittlement kinetics have been compared for the decommissioned reactor components and materials aged under accelerated conditions. On the basis of the study, a mechanistic understanding of the causes of the complex behavior in kinetics and activation energy of aging (i.e., the temperature dependence of aging embrittlement between the accelerated and reactor-operating conditions) is presented. A mechanistic correlation developed thereon is compared with a number of available empirical correlations to provide an insight for development of a better methodology of life prediction of the reactor components. 18 refs., 18 figs., 5 tabs

  1. [Post-operative analgesia in thoracic surgery: physiopathological features, therapeutic framework and methodologies].

    Science.gov (United States)

    Pavia, R; Barresi, P; Puliafito, M; Canciglia, A; Mondello, B

    2006-01-01

    Pain after surgery is a major handicap for patients as it bounds and decreases ability for spontaneous movement, cough and deep breathing, aiding the onset of complications and invalidating the recovery capabilities of operated patients. In thoracic surgery, the need to compile and employ guidelines for post-surgical pain management has become a pressing requirement in recent years. Currently available protocols include several options of treatment that are frequently a subject in the most recent scientific papers and play a key role, as they constitute the framework upon which building with changes and fixes that take account of incidental circumstances, in relation to both patients and surgery, again for both the organizational and structural features of the surgical environment. Purpose of this job is a thorough analysis of post-operating analgesic treatments for thoracic surgery, introducing the most effective ones currently available as for channels and procedures of administration, as well as possible side effects or complications.

  2. The methodological features of teaching subject «Fundamentals of production technologies»

    Directory of Open Access Journals (Sweden)

    Olesya Kornus

    2017-11-01

    Full Text Available In the article are reviews the methodical features teaching of the subject "Fundamentals of production technologies" as an example of training of students in the direction of 6.040104 Geography* and specialty 014 Secondary Education (Geography in the Sumy State A.S. Makarenko Pedagogical University. The subject «Fundamentals of production technologies» was introduced into curriculum bachelor of geography for quality training of geography teachers in pedagogical universities. This subject gives students the knowledge about the technical and economic features of the main industries, main technological schemes of production processes and the impact of industrial enterprises on the environment. The subject «Fundamentals of production technologies» is taught for second year students of natural-geographical faculty of the Sumy State A.S. Makarenko Pedagogical University. The educational process provides lectures, practical classes and self-dependent work. One of the forms of organization of training activities is the excursions to industrial enterprises of Sumy city. The organization of excursions includes preparation, conduct and report about the results of the excursion. For better learn the material excursion, preferably before the start of it to divide a group of students into small teams of 3-6 people. The report documentation includes a plan for characteristic of industrial enterprises, as well as multimedia presentation. The defense of report is passes like competition by voted. The team that wins the most votes gets the highest score. This form of subject study contributes to obtaining of positive educational outcomes and lasting knowledge, reliable formation of professional competencies of students-geographers.

  3. An age estimation method using brain local features for T1-weighted images.

    Science.gov (United States)

    Kondo, Chihiro; Ito, Koichi; Kai Wu; Sato, Kazunori; Taki, Yasuyuki; Fukuda, Hiroshi; Aoki, Takafumi

    2015-08-01

    Previous statistical analysis studies using large-scale brain magnetic resonance (MR) image databases have examined that brain tissues have age-related morphological changes. This fact indicates that one can estimate the age of a subject from his/her brain MR image by evaluating morphological changes with healthy aging. This paper proposes an age estimation method using local features extracted from T1-weighted MR images. The brain local features are defined by volumes of brain tissues parcellated into local regions defined by the automated anatomical labeling atlas. The proposed method selects optimal local regions to improve the performance of age estimation. We evaluate performance of the proposed method using 1,146 T1-weighted images from a Japanese MR image database. We also discuss the medical implication of selected optimal local regions.

  4. MICROSTRUCTURAL FEATURES EVALUATION OF AGE-HARDENED A 226 CAST ALLOY BY IMAGE ANALYSIS

    Directory of Open Access Journals (Sweden)

    Lenka Kuchariková

    2018-01-01

    Full Text Available Age-hardening provides one of the most widely used mechanisms for the strengthening of aluminum alloys. The age-hardening involves three steps: solution treatment, quenching and aging. The temperature of solution treatment and aging is very important in order to reach desired properties of castings. The optimum temperature of solution treatment and aging led to formation microstructural features in form which does not lead to decreasing properties, but increasing ones. The major microstructural features in A 226 cast alloys which are responsible for increasing properties are: eutectic Si particles, Cu-rich phases, Fe-rich phases and porosity. The increase of properties depends on morphology, size and volume of microstructural features. In order to assess age-hardening influence on microstructural features in A226 cast alloys were used as possibilities of evaluation by means of image analysis. Quantitative analysis decelerate changes in microstructure includes the spheroidization and coarsening of eutectic silicon, gradual disintegration, shortening and thinning of Fe-rich intermetallic phases, the dissolution of precipitates and the precipitation of finer hardening phase (Al2Cu further increase in the hardness and tensile strength in the alloy. Changes of mechanical properties were measured in line with STN EN ISO.

  5. An age-related deficit in spatial-feature reference memory in homing pigeons (Columba livia).

    Science.gov (United States)

    Coppola, Vincent J; Flaim, Mary E; Carney, Samantha N; Bingman, Verner P

    2015-03-01

    Age-related memory decline in mammals has been well documented. By contrast, very little is known about memory decline in birds as they age. In the current study we trained younger and older homing pigeons on a reference memory task in which a goal location could be encoded by spatial and feature cues. Consistent with a previous working memory study, the results revealed impaired acquisition of combined spatial-feature reference memory in older compared to younger pigeons. Following memory acquisition, we used cue-conflict probe trials to provide an initial assessment of possible age-related differences in cue preference. Both younger and older pigeons displayed a similarly modest preference for feature over spatial cues. Copyright © 2014 Elsevier B.V. All rights reserved.

  6. Middle-aged women's preferred theory-based features in mobile physical activity applications.

    Science.gov (United States)

    Ehlers, Diane K; Huberty, Jennifer L

    2014-09-01

    The purpose of this study was to describe which theory-based behavioral and technological features middle-aged women prefer to be included in a mobile application designed to help them adopt and maintain regular physical activity (PA). Women aged 30 to 64 years (N = 120) completed an online survey measuring their demographics and mobile PA application preferences. The survey was developed upon behavioral principles of Social Cognitive Theory, recent mobile app research, and technology adoption principles of the Unified Theory of Acceptance and Use of Technology. Frequencies were calculated and content analyses conducted to identify which features women most preferred. Behavioral features that help women self-regulate their PA (PA tracking, goal-setting, progress monitoring) were most preferred. Technological features that enhance perceived effort expectancy and playfulness were most preferred. Many women reported the desire to interact and compete with others through the application. Theory-based PA self-regulation features and theory-based design features that improve perceived effort expectancy and playfulness may be most beneficial in a mobile PA application for middle-aged women. Opportunities to interact with other people and the employment of social, game-like activities may also be attractive. Interdisciplinary engagement of experts in PA behavior change, technology adoption, and software development is needed.

  7. Design Feature and Prototype Testing Methodology of DHIC's Nuclear I and C System

    International Nuclear Information System (INIS)

    Kim, K.H.; Baeg, S.Y.; Kim, S.A.; Lee, S.J.; Yoon, S.P.; Park, C.Y.

    2011-01-01

    The DHIC has developed an I and C system for a nuclear power plant through a Korean Government R and D project since 2001. This I and C system was designed and implemented to be applied for the new 1400MW nuclear power plant of KHNP. This system's design is based on the class-1E PLC platform and the non-class1E DCS platform. The PPS, the ESF-CCS, the RCOPS, the QIAS-P/N, the PCS, the NPCS, the P-CCS and the NIMS were designed, implemented and tested. The R and D project has been developed under a systematic and guided QA plan, but it is not easy to be applied for a new NPP such as Shin-Ulchin 1 and 2. To resolve problems of the first-application concerns, a new idea of integrated performance testing was adopted. A main control room for a verification test facility was constructed and it has features of a compact, video-based man-machine interface. The MCR includes five operation consoles, a Large Display Panel. A test system for a verification test facility is implemented as similar as a control and protection system of SUN 1 and 2. Integration level tests such as a system test, an interface test, a MMI test, a system function/performance test, a failure mode test, a response time test, a network load test, an alarm test, a reactor power cutback system test, an unit load transient test and a scenario test were performed using the prototype test facilities. These kinds of testing can verify and pre-validate the integrated I and C system's performance and flexibility. It could offer an implementation training before construction and also minimize trial errors to be found in the site. (author)

  8. Age and binding within-dimension features in visual short-term memory

    OpenAIRE

    Parra, Mario; Abrahams, S.; Logie, R. H.; Della Sala, S.

    2009-01-01

    Older adults have difficulties in binding information in long-term memory (e.g. objects with colours). The effect of age on visual short-term memory (VSTM) binding is less well understood. Recent evidence has suggested that older adults' VSTM for colours bound to shapes or for locations bound in configural representations may be preserved. In two experiments we investigated whether this lack of an age effect on VSTM for bound features can be reproduced when features are drawn from the same di...

  9. Development and application of the methodology to establish life extension and modernization plan of aged hydropower plants

    International Nuclear Information System (INIS)

    Kim, Jong Sung; Kwon, Hyuck Cheon; Song, Byung Hun; Kwon, Chang Seop

    2009-01-01

    This paper provides how to establish an integrated plan for LE (Life Extension) and MD (MoDernization) of aged hydropower plants. The methodology is developed through review of overseas/domestic LE/MD histories, investigation of the previous overseas methodologies and consideration of domestic practices. The methodology includes reviews of the various factors such as condition, operation and maintenance history, up-to-date technology, and economic benefit. In order to establish the life extension/modernization plan, the methodology is applied to the domestic aged hydropower plants. Finally, priority rankings and draft practice plans for LE/MD are derived.

  10. Methodology on ageing management review for main components of a PWR NPP

    International Nuclear Information System (INIS)

    Dou Yikang; He Yinbiao; Xu Xuelian; Zhang Ming; Liang Xingyun

    2005-01-01

    According to the requirements of NNSA, for Chinese operational NPPs periodical safety review (PSR) should be carried out every 10 years. Ageing management is one of the important safety factors to be reviewed. Entrusted by Qinshan Nuclear Power Plant (QNPP), Shanghai Nuclear Engineering Research and Design Institute (SNERDI) carried out the ageing management review (AMR), as a part of the first PSR of QNPP, from 2001 to 2003. This paper summarizes the methodology of the AMR process, including screening of critical components and structures, identification of main ageing mechanisms and their indicators and the tabulated review process, etc. 15 components and structures, hereafter referred as equipment, were selected as review objects based on their significance of safety, replaceability and cost-benefit considerations. To these objects, the main ageing mechanisms and relevant ageing indicators were identified according to specific working and environmental condition, design and manufacture information, operation and maintenance history, etc. The review can be divided into two parallel parts, the review for specific equipment and the review for overall management procedures and their implementation. To typical components, such as RPV and SG, fatigue analysis based on operational transient accounting was carried out to observe the actual safety margins. Through the review, the weaknesses in ageing management and potential threats to structural integrity were identified and thus continued improvement can be made in the next period of 10 years. (authors)

  11. The verification methodologies for a software modeling of Engineered Safety Features- Component Control System (ESF-CCS)

    International Nuclear Information System (INIS)

    Lee, Young-Jun; Cheon, Se-Woo; Cha, Kyung-Ho; Park, Gee-Yong; Kwon, Kee-Choon

    2007-01-01

    The safety of a software is not guaranteed through a simple testing of the software. The testing reviews only the static functions of a software. The behavior, dynamic state of a software is not reviewed by a software testing. The Ariane5 rocket accident and the failure of the Virtual Case File Project are determined by a software fault. Although this software was tested thoroughly, the potential errors existed internally. There are a lot of methods to solve these problems. One of the methods is a formal methodology. It describes the software requirements as a formal specification during a software life cycle and verifies a specified design. This paper suggests the methods which verify the design to be described as a formal specification. We adapt these methods to the software of a ESF-CCS (Engineered Safety Features-Component Control System) and use the SCADE (Safety Critical Application Development Environment) tool for adopting the suggested verification methods

  12. EEG features of absence seizures in idiopathic generalized epilepsy: Impact of syndrome, age, and state

    DEFF Research Database (Denmark)

    Sadleir, L.G.; Scheffer, I.E.; Smith, S.

    2009-01-01

    Purpose: Factors influencing the electroencephalography (EEG) features of absence seizures in newly presenting children with idiopathic generalized epilepsy (IGE) have not been rigorously studied. We examined how specific factors such as state, provocation, age, and epilepsy syndrome affect the EEG...... features of absence seizures. Methods: Children with untreated absence seizures were studied using video-EEG recording. The influence of state of arousal, provocation (hyperventilation, photic stimulation), age, and epilepsy syndrome on specific EEG features was analyzed. Results: Five hundred nine...... seizures were evaluated in 70 children with the following syndromes: childhood absence epilepsy (CAE) 37, CAE+ photoparoxysmal response (PPR) 10, juvenile absence epilepsy (JAE) 8, juvenile myoclonic epilepsy (JME) 6, and unclassified 9. Polyspikes occurred in all syndromes but were more common in JME...

  13. Feature Binding of Common Everyday Items Is Not Affected by Age

    Directory of Open Access Journals (Sweden)

    Serge Hoefeijzers

    2017-05-01

    Full Text Available There is a surge of studies confirming that old age spares the ability to bind in visual working memory (VWM multiple features within singular object representations. Furthermore, it has been suggested that such ability may also be independent of the cultural background of the assessed individual. However, this evidence has been gathered with tasks that use arbitrary bindings of unfamiliar features. Whether age spares memory binding functions when the memoranda are features of everyday life objects remains less well explored. The present study investigated the influence of age, memory delay, and education, on conjunctive binding functions responsible for representing everyday items in VWM. We asked 32 healthy young and 41 healthy older adults to perform a memory binding task. During the task, participants saw visual arrays of objects, colours, or coloured objects presented for 6 s. Immediately after they were asked either to select the objects or the colours that were presented during the study display from larger sets of objects or colours, or to recombine them by selecting from such sets the objects and their corresponding colours. This procedure was repeated immediately after but this time providing a 30 s unfiled delay. We manipulated familiarity by presenting congruent and incongruent object-colour pairings. The results showed that the ability to bind intrinsic features in VWM does not decline with age even when these features belong to everyday items and form novel or well-known associations. Such preserved memory binding abilities held across memory delays. The impact of feature congruency on item-recognition appears to be greater in older than in younger adults. This suggests that long-term memory (LTM supports binding functions carried out in VWM for familiar everyday items and older adults still benefit from this LTM support. We have expanded the evidence supporting the lack of age effects on VWM binding functions to new feature and

  14. Maternal employment and Mexican school-age children overweight in 2012: the importance of households features.

    Science.gov (United States)

    Espinosa, Alejandro Martínez

    2018-01-01

    International evidence regarding the relationship between maternal employment and school-age children overweight and obesity shows divergent results. In Mexico, this relationship has not been confirmed by national data sets analysis. Consequently, the objective of this article was to evaluate the role of the mothers' participation in labor force related to excess body weight in Mexican school-age children (aged 5-11 years). A cross-sectional study was conducted on a sample of 17,418 individuals from the National Health and Nutrition Survey 2012, applying binomial logistic regression models. After controlling for individual, maternal and contextual features, the mothers' participation in labor force was associated with children body composition. However, when the household features (living arrangements, household ethnicity, size, food security and socioeconomic status) were incorporated, maternal employment was no longer statically significant. Household features are crucial factors for understanding the overweight and obesity prevalence levels in Mexican school-age children, despite the mother having a paid job. Copyright: © 2018 Permanyer.

  15. Home and Health in the Third AgeMethodological Background and Descriptive Findings

    Directory of Open Access Journals (Sweden)

    Maya Kylén

    2014-07-01

    Full Text Available Background: The understanding of the complex relationship between the home environment, well-being and daily functioning in the third age is currently weak. The aim of this paper is to present the methodological background of the Home and Health in the Third Age Study, and describe a sample of men and women in relation to their home and health situation. Methods and Design: The study sample included 371 people aged 67–70, living in ordinary housing in the south of Sweden. Structured interviews and observations were conducted to collect data about objective and perceived aspects of home and health. Results: The majority of the participants were in good health and had few functional limitations. Women had more functional limitations and reported more symptoms than men. Environmental barriers were found in every home investigated; the most were found in the kitchen and hygiene area. Environmental barriers were more common in multi-family than in one-family dwellings. Discussion: This study will increase our knowledge on home and health dynamics among people in the third age. The results have potential to contribute to societal planning related to housing provision, home care and social services for senior citizens.

  16. Home and Health in the Third AgeMethodological Background and Descriptive Findings

    Science.gov (United States)

    Kylén, Maya; Ekström, Henrik; Haak, Maria; Elmståhl, Sölve; Iwarsson, Susanne

    2014-01-01

    Background: The understanding of the complex relationship between the home environment, well-being and daily functioning in the third age is currently weak. The aim of this paper is to present the methodological background of the Home and Health in the Third Age Study, and describe a sample of men and women in relation to their home and health situation. Methods and Design: The study sample included 371 people aged 67–70, living in ordinary housing in the south of Sweden. Structured interviews and observations were conducted to collect data about objective and perceived aspects of home and health. Results: The majority of the participants were in good health and had few functional limitations. Women had more functional limitations and reported more symptoms than men. Environmental barriers were found in every home investigated; the most were found in the kitchen and hygiene area. Environmental barriers were more common in multi-family than in one-family dwellings. Discussion: This study will increase our knowledge on home and health dynamics among people in the third age. The results have potential to contribute to societal planning related to housing provision, home care and social services for senior citizens. PMID:25019267

  17. Aging and feature binding in visual working memory: The role of presentation time.

    OpenAIRE

    Rhodes, Stephen; Parra, Mario; Logie, Robert

    2015-01-01

    A large body of research has clearly demonstrated that healthy ageing is accompanied by an associative memory deficit. Older adults exhibit disproportionately poor performance on memory tasks requiring the retention of associations between items (e.g. pairs of unrelated words). In contrast to this robust deficit, older adults’ ability to form and temporarily hold bound representations of an object’s surface features, such as colour and shape, appears to be relatively well preserved. However, ...

  18. Aging linear viscoelasticity of matrix-inclusion composite materials featuring ellipsoidal inclusions

    OpenAIRE

    LAVERGNE, Francis; SAB, Karam; SANAHUJA, Julien; BORNERT, Michel; TOULEMONDE, Charles

    2016-01-01

    A multi-scale homogenization scheme is proposed to estimate the time-dependent strains of fiber-reinforced concrete. This material is modeled as an aging linear viscoelastic composite material featuring ellipsoidal inclusions embedded in a viscoelastic cementitious matrix characterized by a time-dependent Poisson's ratio. To this end, the homogenization scheme proposed in Lavergne et al. [1] is adapted to the case of a time-dependent Poisson's ratio and it is successfully validated on a non-a...

  19. Feature-selective attention in healthy old age: a selective decline in selective attention?

    Science.gov (United States)

    Quigley, Cliodhna; Müller, Matthias M

    2014-02-12

    Deficient selection against irrelevant information has been proposed to underlie age-related cognitive decline. We recently reported evidence for maintained early sensory selection when older and younger adults used spatial selective attention to perform a challenging task. Here we explored age-related differences when spatial selection is not possible and feature-selective attention must be deployed. We additionally compared the integrity of feedforward processing by exploiting the well established phenomenon of suppression of visual cortical responses attributable to interstimulus competition. Electroencephalogram was measured while older and younger human adults responded to brief occurrences of coherent motion in an attended stimulus composed of randomly moving, orientation-defined, flickering bars. Attention was directed to horizontal or vertical bars by a pretrial cue, after which two orthogonally oriented, overlapping stimuli or a single stimulus were presented. Horizontal and vertical bars flickered at different frequencies and thereby elicited separable steady-state visual-evoked potentials, which were used to examine the effect of feature-based selection and the competitive influence of a second stimulus on ongoing visual processing. Age differences were found in feature-selective attentional modulation of visual responses: older adults did not show consistent modulation of magnitude or phase. In contrast, the suppressive effect of a second stimulus was robust and comparable in magnitude across age groups, suggesting that bottom-up processing of the current stimuli is essentially unchanged in healthy old age. Thus, it seems that visual processing per se is unchanged, but top-down attentional control is compromised in older adults when space cannot be used to guide selection.

  20. Clinicopathological features of patients with breast cancer aged 70 years or over.

    Science.gov (United States)

    Aytekin, Aydin; Karatas, Fatih; Sahin, Suleyman; Erdem, Gokmen U; Altundag, Kadri

    2017-01-01

    The risk of breast cancer (BC) increases in parallel with increasing age. Despite the increased disease burden in elderly patients, there is still a great uncertainty regarding "how to manage" BC in aging-population. The purpose of this study was to investigate the clinicopathological features and treatment approaches of patients with BC aged 70 years or over. The medical records of 4413 patients with BC followed between 1994-2015 were retrospectively analyzed. Of the 4413 patients, 238 with stage I to III disease aged 70 years or over at BC diagnosis were enrolled into this study. Patients were divided into 2 groups according to the age as group 1 (70-79 years, N=192) and group 2 (80 or over, N=46). Clinicopathological features of patients including tumor histology, grade, estrogen (ER) and progesterone receptor (PgR) status, human epidermal growth factor receptor 2 (HER2) status, tumor size, lymph node involvement (LNI), lymphovascular invasion (LVI), perineural invasion (PNI), clinical stage, type of surgery, treatments and comorbid diseases were evaluated. The median age was 74 for group 1 (range 70-79) and 82 for group 2 (range 80-92). Excluding tumor size and grade, no statictically significant difference was found between the two groups according to histopathological characteristics. Patients in group 2 had more commonly larger T stage (T4), and less frequently presented with grade I tumor (p=0.014 and p=0.044, respectively). Modified radical mastectomy and adjuvant chemotherapy were more commonly performed in group 1 (p=0.001 and p=0.001, respectively). In contrast, neoadjuvant treatment was more frequently applied in group 2 (p=0.003). There was no difference in disease-free survival (DFS) between the groups (p=0.012), however, median overall survival (OS) was significantly higher in group 1 (p=0.03). Excluding the tumor grade and tumor size, both groups had similar histopathological features. However, patients aged between 70-79 years were likely to

  1. Age-related changes of adaptive and neuropsychological features in persons with Down Syndrome.

    Directory of Open Access Journals (Sweden)

    Alessandro Ghezzo

    Full Text Available Down Syndrome (DS is characterised by premature aging and an accelerated decline of cognitive functions in the vast majority of cases. As the life expectancy of DS persons is rapidly increasing, this decline is becoming a dramatic health problem. The aim of this study was to thoroughly evaluate a group of 67 non-demented persons with DS of different ages (11 to 66 years, from a neuropsychological, neuropsychiatric and psychomotor point of view in order to evaluate in a cross-sectional study the age-related adaptive and neuropsychological features, and to possibly identify early signs predictive of cognitive decline. The main finding of this study is that both neuropsychological functions and adaptive skills are lower in adult DS persons over 40 years old, compared to younger ones. In particular, language and short memory skills, frontal lobe functions, visuo-spatial abilities and adaptive behaviour appear to be the more affected domains. A growing deficit in verbal comprehension, along with social isolation, loss of interest and greater fatigue in daily tasks, are the main features found in older, non demented DS persons evaluated in our study. It is proposed that these signs can be alarm bells for incipient dementia, and that neuro-cognitive rehabilitation and psycho-pharmacological interventions must start as soon as the fourth decade (or even earlier in DS persons, i.e. at an age where interventions can have the greatest efficacy.

  2. Age-dependent risk-based methodology and its application to prioritization of nuclear power plant components and to maintenance for managing aging using PRAs

    International Nuclear Information System (INIS)

    Levy, I.S.; Vesely, W.E.

    1990-01-01

    This paper is based on a study to demonstrate several important ways that the age-dependent risk-based methodology developed by the Nuclear Plant Aging Research (NPAR) Program may be applied to resolving important issues related to the aging of nuclear power plant systems, structures, and components (SSCs). The study was sponsored by the NPAR Program of the Division of Engineering, Office of Nuclear Regulatory Research of the U.S. Nuclear Regulatory Commission (NRC). Initiated on the basis of a Users Need Request, the age-dependent risk-based methodology has been under development by the NPAR Program for several years. In this methodology, the time-dependent change in a component's risk contribution is the product of two factors: (1) the risk importance of the component (e.g., the change in its risk contribution when it is assumed to be totally unavailable to perform its intended safety function) and (2) the change in its unavailability with time. This change in the component's unavailability with time is a function of the component's aging rate and plant inspection and maintenance practices. The methodology permits evaluations of the age-dependent risk contributions from both single- and multiple-components. Principal results and conclusions generated by the methodology demonstrations are discussed

  3. Low levels of serum testosterone in middle-aged men impact pathological features of prostate cancer.

    Science.gov (United States)

    Llukani, Elton; Katz, Benjamin F; Agalliu, Ilir; Lightfoot, Andrew; Yu, Sue-Jean S; Kathrins, Martin; Lee, Ziho; Su, Yu-Kai; Monahan Agnew, Kelly; McGill, Alice; Eun, Daniel D; Lee, David I

    2017-03-01

    Serum testosterone deficiency increases with aging. Age is also a major risk factor for prostate cancer (PrCa) and PCa tumors are more frequently diagnosed among men >65 years old. We evaluated the relationship between preoperative serum testosterone and clinical/ pathological features of PrCa in middle-aged and elderly patients. A total of 605 PrCa patients who underwent robotic-assisted radical prostatectomy between September 2010 and January 2013 at the University of Pennsylvania, and who had serum testosterone levels measured using Elecsys Testosterone II Immunoassay were included in this IRB-approved protocol. Androgen deficiency was determined as serum free testosterone (FT) men with low vs. normal TT or FT were compared using t-test or chi-square tests. Logistic regression was used to determine associations of clinical and pathological variables with FT or TT levels. Among middle-aged men (45-64 years; n = 367), those with low FT and low TT had, on average, a higher BMI (29.7 vs. 27.4, P men with normal FT and normal TT values. Patients with low FT had also higher number of positive cores on biopsy (3.9 vs. 3.1 P = 0.019) and greater tumor volume (7.9 ml vs. 6.1 ml, P = 0.045) compared to those with normal FT. Among men ≥65 years ( n = 135) there was no difference in prostatectomy specimens of PrCa between patients with low or normal FT or TT. Among men aged 45-64 years low serum pretreatment FT and TT predicted more aggressive features of PrCa in prostatectomy specimens. In middle-aged patients low testosterone levels measured pre-operatively may indicate more aggressive disease parameters.

  4. Ageing and feature binding in visual working memory: The role of presentation time.

    Science.gov (United States)

    Rhodes, Stephen; Parra, Mario A; Logie, Robert H

    2016-01-01

    A large body of research has clearly demonstrated that healthy ageing is accompanied by an associative memory deficit. Older adults exhibit disproportionately poor performance on memory tasks requiring the retention of associations between items (e.g., pairs of unrelated words). In contrast to this robust deficit, older adults' ability to form and temporarily hold bound representations of an object's surface features, such as colour and shape, appears to be relatively well preserved. However, the findings of one set of experiments suggest that older adults may struggle to form temporary bound representations in visual working memory when given more time to study objects. However, these findings were based on between-participant comparisons across experimental paradigms. The present study directly assesses the role of presentation time in the ability of younger and older adults to bind shape and colour in visual working memory using a within-participant design. We report new evidence that giving older adults longer to study memory objects does not differentially affect their immediate memory for feature combinations relative to individual features. This is in line with a growing body of research suggesting that there is no age-related impairment in immediate memory for colour-shape binding.

  5. A Model-Based Prognostics Methodology For Electrolytic Capacitors Based On Electrical Overstress Accelerated Aging

    Data.gov (United States)

    National Aeronautics and Space Administration — A remaining useful life prediction methodology for electrolytic capacitors is presented. This methodology is based on the Kalman filter framework and an empirical...

  6. A Model-based Prognostics Methodology for Electrolytic Capacitors Based on Electrical Overstress Accelerated Aging

    Data.gov (United States)

    National Aeronautics and Space Administration — A remaining useful life prediction methodology for elec- trolytic capacitors is presented. This methodology is based on the Kalman filter framework and an empirical...

  7. Gender and age features of the self-concept of a pensioner

    Directory of Open Access Journals (Sweden)

    Natalia Yu. Marchuk

    2017-06-01

    Full Text Available Currently the Ministry of Finance is working on the issue of gradual increase of the retirement age, while various specialists are actively discussing the pros and cons of this potential change. The issue of determining the characteristics of the labour force participation of elder people and their participation in society is complex and multifaceted. A retired person’s capability for activity, willingness to get enrolled in society vary considerably depending on health, psychological well-being, self-attitude. The paper examines one’s self-concept as a generalized set of ideas about their own physical, psychological, social features As a central component of identity and self-regulation of the retired citizens. The results of the study presented in the paper reveal the retirement age as a period of human ontogenesis, during which their self-concept is undergoing a number of changes. Based on the theoretical analysis and empirical research, the following periods of the individual development at the retirement age is proposed: early retirement, mid retirement, late retirement. Each of the periods is described taking into account age peculiarities of self-awareness and the self-concept. The paper shows the crisis nature of the self-concept development in people of the retirement age. It also highlights normative age-graded crises: the retirement crisis, the crisis of self-sufficiency, the crisis of integrity. The paper also highlights gender-specific features of the self-concept in retired citizens. The study was conducted using a sample of 120 unemployed pensioners from the cities Yekaterinburg and Sverdlovsk Oblast (Sverdlovsk region, Russia. To study the features of the self-concept of the retired citizens the following methods were used: «Who am I?» (M. Kun for studying the content of the self-concept, the self-relation test (V. V. Stolin, S. R. Pantileev for analysinge self-attitude of the retired citizens, the technique of personal

  8. Nutrient Canals of the Alveolar Process as an Anatomical Feature for Age and Gender Determination

    Directory of Open Access Journals (Sweden)

    Prashant Gupta

    2017-01-01

    Full Text Available Introduction: Nutrient canals are anatomic structures of the alveolar bone through which neurovascular elements transit to supply teeth and supporting structures. Dental identification using nutrient canal of the mandibular alveolar process as the most compelling anatomic feature for antemortem–postmortem radiographic comparison can be potentially used in forensic identification. Aim: The aim of the present study was to investigate the correlation between the appearance of nutrient canals as a potential clue to age and gender determination. Materials and Methods: One hundred and twenty patients, 60 males and 60 females, were selected in the 11–60-year age group. Systemic disease, especially hypertension, was ruled out in the patients. Periapical radiographs were taken from mandibular anterior cuspid central incisor region because nutrient canals are commonly observed in this area. Data obtained was analyzed by SPSS software and various statistical analysis were carried out. Results: Study revealed nutrient canals to be commonly seen in females compared to males. Males had maximum canals in the age group of 21–30-year whereas females in the age group of 31–40 years had the maximum canals. Conclusion: Significant correlation was seen between the gender and nutrient canals whereas no significant correlation existed between the age and presence of nutrient canals.

  9. Effects of Individual Differences and Situational Features on Age Differences in Mindless Reading.

    Science.gov (United States)

    Shake, Matthew C; Shulley, Leah J; Soto-Freita, Angelica M

    2016-09-01

    Mindless reading occurs when an individual shifts their attention away from the text and toward other off-task thoughts. This study examined whether previously reported age-related declines in mindless reading episodes are due primarily to (a) situational features related to the text itself (e.g., text genre or interest in the text) and/or (b) individual differences in cognitive ability. Participants read 2 texts written in different genres but about the same topic. During reading, they were randomly probed to indicate whether they were on-task or mind-wandering. They also indicated their perceptions regarding the interest and difficulty of the text, and completed a battery of cognitive ability measures. The results showed that (a) text genre may engender some age differences in mindless reading and (b) greater age and perceived interest in the text were each uniquely predictive of reduced mindless reading for both text genres. Individual differences in cognitive abilities (e.g., working memory, vocabulary) did not account for additional significant variance in mindless reading after interest and age were taken into account. Our findings are discussed in terms of implications for age differences in lapses of attention during reading and predictors of mind-wandering generally. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  10. Clinical Features of Human Metapneumovirus Infection in Ambulatory Children Aged 5-13 Years.

    Science.gov (United States)

    Howard, Leigh M; Edwards, Kathryn M; Zhu, Yuwei; Griffin, Marie R; Weinberg, Geoffrey A; Szilagyi, Peter G; Staat, Mary A; Payne, Daniel C; Williams, John V

    2018-05-15

    We detected human metapneumovirus (HMPV) in 54 (5%) of 1055 children aged 5 to 13 years with acute respiratory illness (ARI) identified by outpatient and emergency department surveillance between November and May 2003-2009. Its clinical features were similar to those of HMPV-negative ARI, except a diagnosis of pneumonia was more likely (13% vs 4%, respectively; P = .005) and a diagnosis of pharyngitis (7% vs 24%, respectively; P = .005) was less likely in patients with HMPV- positive ARI than those with HMPV-negative ARI.

  11. Distinct features of trampoline-related orthopedic injuries in children aged under 6 years.

    Science.gov (United States)

    Choi, Eun Seok; Hong, Jin Heon; Sim, Jae Ang

    2018-02-01

    Concern has been growing about trampoline-related injuries among young children. Several published policy statements have repeatedly recommended that children younger than 6 years should not use trampolines. However, few studies have investigated the injuries caused by trampoline-related accidents among young children. This study aimed to identify the distinct features of trampoline-related orthopedic injuries in children younger than 6 years. We retrospectively reviewed the medical records of pediatric patients aged between 0 and 16 years who visited our regional emergency center due to trampoline-related orthopedic injuries between 2012 and 2015. Patients were divided into two groups: a preschool group (younger than 6 years) and a school group (older than 6 years). We compared the features of the injuries in the two groups. Among 208 patients, 108 (52%) were male and 100 (48%) were female. The mean age was 5.4 years. The preschool group accounted for 66%. There were no seasonal variations. Fractures were sustained in 96 patients (46%). The anatomical locations of injuries differed significantly between the two age groups. Proximal tibia fractures were more frequent in the preschool group than the school group (34% and 6%, respectively). Distal tibia fractures were more prevalent in the school group than the preschool group (44% vs. 13%, respectively). Surgical treatment was needed more frequently in the school group (p = 0.035, hazard ratio 2.52, 95% confidence interval: 1.03-6.17). Most of the injuries (82%) occurred at trampoline parks. The anatomical locations of trampoline-related orthopedic injuries differed significantly between age groups. Fractures were more common around the knee in younger children and the ankle in older children. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. [Age-related features of neuromuscular function in rats with hyperthyroidism].

    Science.gov (United States)

    Nerush, P O; Makiĭ, Ie A; Rodyns'kyĭ, O H

    2001-01-01

    Studied features of functioning of nervous-muscular system at white rats of two age groups: preadolescent (5 weeks) and puberal (24 weeks), in conditions experimental hyperthyroidism (HT). It is established, that in conditions HT at action of the raised concentration thyroxine characteristics of excitation gastrocnemius muscles essentially changed at irritation of a sciatic nerve in groups preadolescent and puberal animals. In all age groups in conditions HT increase of a threshold of excitation gastrocnemius muscles is marked at indirect stimulation and decrease at direct stimulation; also in all age groups in conditions HT reduction of time chronaxy muscles is fixed, both at direct, and at indirect irritation. At preadolescent animals, as against puberal in conditions HT at action of the raised concentration thyroxine on nervous-muscular system it is not revealed authentic change of the latent period and amplitude of potential of action (PA). The conclusion is made, that in conditions HT change of a threshold of excitation and chronaxy gastrocnemius muscles both at direct, and at indirect irritation do not carry age specificity and have an identical orientation, both at preadolescent, and at puberal rats. At preadolescent animals in conditions HT, as against puberal the parameter of amplitude and latent period PA authentically did not change, that can testify to smaller sensitivity of the caused answers gastrocnemius muscles to the raised concentration thyroxine, probably, by virtue of immaturity peripheral neuromotor the device.

  13. Carotid plaque age is a feature of plaque stability inversely related to levels of plasma insulin.

    Directory of Open Access Journals (Sweden)

    Sara Hägg

    Full Text Available BACKGROUND: The stability of atherosclerotic plaques determines the risk for rupture, which may lead to thrombus formation and potentially severe clinical complications such as myocardial infarction and stroke. Although the rate of plaque formation may be important for plaque stability, this process is not well understood. We took advantage of the atmospheric (14C-declination curve (a result of the atomic bomb tests in the 1950s and 1960s to determine the average biological age of carotid plaques. METHODOLOGY/PRINCIPAL FINDING: The cores of carotid plaques were dissected from 29 well-characterized, symptomatic patients with carotid stenosis and analyzed for (14C content by accelerator mass spectrometry. The average plaque age (i.e. formation time was 9.6±3.3 years. All but two plaques had formed within 5-15 years before surgery. Plaque age was not associated with the chronological ages of the patients but was inversely related to plasma insulin levels (p = 0.0014. Most plaques were echo-lucent rather than echo-rich (2.24±0.97, range 1-5. However, plaques in the lowest tercile of plaque age (most recently formed were characterized by further instability with a higher content of lipids and macrophages (67.8±12.4 vs. 50.4±6.2, p = 0.00005; 57.6±26.1 vs. 39.8±25.7, p<0.0005, respectively, less collagen (45.3±6.1 vs. 51.1±9.8, p<0.05, and fewer smooth muscle cells (130±31 vs. 141±21, p<0.05 than plaques in the highest tercile. Microarray analysis of plaques in the lowest tercile also showed increased activity of genes involved in immune responses and oxidative phosphorylation. CONCLUSIONS/SIGNIFICANCE: Our results show, for the first time, that plaque age, as judge by relative incorporation of (14C, can improve our understanding of carotid plaque stability and therefore risk for clinical complications. Our results also suggest that levels of plasma insulin might be involved in determining carotid plaque age.

  14. What vehicle features are considered important when buying an automobile? An examination of driver preferences by age and gender.

    Science.gov (United States)

    Vrkljan, Brenda H; Anaby, Dana

    2011-02-01

    Certain vehicle features can help drivers avoid collisions and/or protect occupants in the event of a crash, and therefore, might play an important role when deciding which vehicle to purchase. The objective of this study was to examine the importance attributed to key vehicle features (including safety) that drivers consider when buying a car and its association with age and gender. A sample of 2,002 Canadian drivers aged 18 years and older completed a survey that asked them to rank the importance of eight vehicle features if they were to purchase a vehicle (storage, mileage, safety, price, comfort, performance, design, and reliability). ANOVA tests were performed to: (a) determine if there were differences in the level of importance between features and; (b) examine the effect of age and gender on the importance attributed to these features. Of the features examined, safety and reliability were the most highly rated in terms of importance, whereas design and performance had the lowest rating. Differences in safety and performance across age groups were dependent on gender. This effect was most evident in the youngest and oldest age groups. Safety and reliability were considered the most important features. Age and gender play a significant role in explaining the importance of certain features. Targeted efforts for translating safety-related information to the youngest and oldest consumers should be emphasized due to their high collision, injury, and fatality rates. Copyright © 2011 National Safety Council and Elsevier Ltd. All rights reserved.

  15. Influence of tritium aging on kinetics feature of LaNi4.9Al0.1

    International Nuclear Information System (INIS)

    Xiong Yifu; Luo Deli; Li Rong

    2001-01-01

    Kinetics parameters were measured at different aging time on LaNi 4.9 Al 0.1 alloy. The influence of tritium aging on kinetics feature of LaNi 4.9 Al 0.1 alloy was assessed. The results show that tritium aging does not change deuterating-dedeuterating reaction order. Reaction rate decrease with aging time. Activation energy (E) increases with aging time

  16. Mirror on the wall: a study of women's perception of facial features as they age.

    Science.gov (United States)

    Sezgin, Billur; Findikcioglu, Kemal; Kaya, Basar; Sibar, Serhat; Yavuzer, Reha

    2012-05-01

    Facial aesthetic treatments are among the most popular cosmetic procedures worldwide, but the factors that motivate women to change their facial appearance are not fully understood. The authors examine the relationships among the facial areas on which women focus most as they age, women's general self-perception, and the effect of their personal focus on "beauty points" on their perception of other women's faces. In this prospective study, 200 women who presented to a cosmetic surgery outpatient clinic for consultation between December 2009 and February 2010 completed a questionnaire. The 200 participants were grouped by age: 20-29 years, 30-39, 40-49, and 50 or older (50 women in each group). They were asked which part of their face they focus on most when looking in the mirror, which part they notice most in other women (of different age groups), what they like/dislike most about their own face, and whether they wished to change any facial feature. A positive correlation was found between women's focal points and the areas they dislike or desire to change. Younger women focused mainly on their nose and skin, while older women focused on their periorbital area and jawline. Women focus on their personal focal points when looking at other women in their 20s and 30s, but not when looking at older women. Women presenting for cosmetic surgery consultation focus on the areas that they dislike most, which leads to a desire to change those features. The plastic surgeon must fully understand patients' expectations to select appropriate candidates and maximize satisfaction with the outcomes.

  17. Breast cancer features in women under the age of 40 years

    Directory of Open Access Journals (Sweden)

    Deise Santiago Girão Eugênio

    Full Text Available Summary Objective: To describe the clinical features, imaging findings and pathological aspects of breast cancer diagnosed in women under the age of 40 years. Method: A retrospective, descriptive study was performed through analysis of medical records between November 2008 and August 2012. One hundred and twenty (120 patients were included, of whom 112 underwent mammography, 113 underwent ultrasonography, and 105 underwent magnetic resonance imaging (MRI. The histopathological data was obtained in most cases from post-surgical analysis, which was available for 113 patients. Results: The mean age at diagnosis of primary breast cancer was 34 years. Only 11 patients (9.0% had a family history of breast or ovarian cancer in first-degree relative. Ninety-two (92 patients sought medical attention after showing breast symptoms, and the presence of a palpable nodule was the main complaint. One hundred and twenty-two (122 primary tumors were diagnosed, of which 112 were invasive (95%. The most common histological type was invasive ductal carcinoma (73.8%. Luminal B was the predominant molecular subtype (42.6%. Ultrasonography was positive in 94.5% of the cases and the most common finding were nodules (94.8%. At mammography, the malignancy was observed in 92.8% and the presence of suggestive calcifications was the dominant feature. The MRI was positive in 98% of patients, and mass lesions were the most common. Conclusion: Most cases of breast cancer diagnosed in patients under the age of 40 years, in our population, had symptoms at diagnosis and tumor with more aggressive biological behavior. Despite the ultrasound has been the most widely used method, we found improved characterization of breast lesions when also used mammography and MRI.

  18. DEVELOPMENT VARIABILITY OF LONGITUDINAL SPINE FEATURES IN CHILDREN AGING 7-15 YEARS OLD

    Directory of Open Access Journals (Sweden)

    Katarzyna Kochan

    2010-06-01

    Full Text Available Introduction. Increased body growth is connected with higher sensitivity to environmental influence and may be a cause of instability of body posture. This happens when trunk and lower limbs growth is more intense. Because body posture disorders are most often diagnosed in children and school adolescents, the sample chosen were subjects between 7 and 15 years old. Material and methods. The data was gathered in 2002 in the town of Polkowice. Examination concerned 2706 boys and girls aged 7 to 15 years old. The measurement included basic somatic features and for the body posture photogrammetric method was used. Results. It was indicated that the relative trunk length in both sexes was decreasing in early school period but in the three oldest groups of age there was a significant increase. The height of kyphosis was increasing significantly in both sexes with age. Most intensive growth of this parameter was observed between 12 and 13 years old subjects. In both sexes there could be seen significant increase of kyphosis depth between 12 and 14 years old and also the decrease of lumbar lordosis between 12 and 13 years old subjects. Conclusion. Significant increase of thoracical spine relative height and lumbar lordosis depth in adolescents in both sexes can be one of the causes of weakening spine stability and affect correct body posture development.

  19. Characteristic sonographic and follow up features of thyroid nodules according to children age groups

    International Nuclear Information System (INIS)

    Nam, Bo Da; Chang, Yun Woo; Hong, Seong Sook; Hwang, Ji Young; Lim, Hyun Kyung; Lee, Jeong Ho; Lee, Dong Hwan

    2016-01-01

    We analyzed the spectrum and the significance of pediatric thyroid nodules depicted on sonography and evaluated the follow-up change according to the age group. We retrospectively reviewed the sonographic features of 82 nodules in 69 patients (6.6%) among 1282 children less than 13 years of age without a palpable lesion, from January 2006 to January 2013. Patients were divided into three age groups; infants, preschoolers, and schoolers. Thyroid nodules were evaluated according to their sonographic characteristics (simple cyst, colloid cyst, solid mass, or intrathyroid thymus) and the changes detected at follow-up (disappearance, decrease in size, no change or increase in size) were reported. There was a significant difference in the nodule patterns among the age groups (p < 0.001). The nodules in infants included a simple cyst (n = 12), a solid mass (n = 12), or an intra-thyroid thymus (n = 9). The preschoolers had a simple cyst (n = 11), a colloid cyst (n = 5), a solid mass (n = 3) or an intra-thyroid thymus (n = 5). However, the schoolers had a simple cyst (n = 2), a colloid cyst (n = 18), and a solid mass (n = 5), but there was no case of intra-thyroid thymus. Follow-up of 38 cases revealed significant differences among the age groups (p = 0.018). The nodules in infants showed findings such as disappearance of nodules (n = 9) and no change (n = 10) on follow-up sonography. In preschoolers, the nodules had disappeared (n = 2), decreased in size (n = 1), and showed no change (n = 11). However, the nodules in schoolers were found to be decreased in size (n = 1), show no change (n = 2), and increased in size (n = 2). The proven pathologic finding was benign in four patients. There were significant differences in the prevalence and the interval change of thyroid nodules among infants, preschoolers, and schoolers. A large series of intrathyroid thymus was seen in infants and preschoolers, and masses did not increase in size in these age groups. The frequency of a

  20. Short term memory for single surface features and bindings in ageing: A replication study.

    Science.gov (United States)

    Isella, Valeria; Molteni, Federica; Mapelli, Cristina; Ferrarese, Carlo

    2015-06-01

    In the present study we replicated a previous experiment investigating visuo-spatial short term memory binding in young and older healthy individuals, in the attempt to verify the pattern of impairment that can be observed in normal elderly for short term memory for single items vs short term memory for bindings. Assessing a larger sample size (25 young and 25 older subjects), using a more appropriate measure of accuracy for a change detection task (A'), and adding the evaluation of speed of performance, we confirmed that old normals show a decline in short term memory for bindings of shape and colour that is of comparable extent, and not major, to the decline in memory for single shapes and single colours. The absence of a specific deficit of short term memory for conjunctions of surface features seems to distinguish cognitive ageing from Alzheimer's Disease. Copyright © 2015 Elsevier Inc. All rights reserved.

  1. Age features of myocardial remodeling in men with ischemic chronic heart failure and renal dysfunction

    Directory of Open Access Journals (Sweden)

    D. A. Lashkul

    2014-04-01

    Full Text Available In recent years, medicine has faced the problem of "dual epidemic" of heart and kidney failure. Regardless of the degree of heart failure, chronic kidney disease increases the risk of death and cardiac decompensation. Left ventricular hypertrophy (LVH is a well known option of cardiac remodeling and it has higher prevalence among people with impaired renal function. Types of myocardial remodeling identify mortality risk of patients with cardiovascular complications. We know that gender and age are important risk factors for cardiovascular disease. However, in most studies structural remodeling of the myocardium was analyzed without sex and age characteristics. The aim of research is to study the age features of the formation of different types of myocardial remodeling in men with ischemic chronic heart failure and renal dysfunction. Materials and methods. To investigate the age characteristics of cardiac remodeling in men with ischemic chronic heart failure and renal dysfunction structural and functional remodeling of left ventricular myocardium was studied in 277 men (mean age 58,1±9,3 years using Doppler echocardiography. Depending on the glomerular filtration rate, patients were divided into 3 groups: 58 with normal GFR (>90 ml/min/1.73m2, 182 with a slight decrease in GFR (60-90 ml/min/1.73m2 and 37 with moderately reduced GFR (<60 ml/min/1.73m2. Echocardiography was performed using the General Electric VIVID 3 system (General Electric Healthcare, USA with the 2.5–3.5 MHz transducer and Doppler technique. Descriptive statistics are presented as mean±standard deviation for continuous variables and as percentages for categorical variables. Depending on the distribution of the analyzed parameters unpaired Student's t-test or U-Mann-Whitney test were used. Comparisons among all groups for baseline clinical variables were performed with the Pearson χ2 or Fisher exact test for categorical variables. Differences were considered reliable for

  2. The Health Behaviour in School-aged Children (HBSC) study: methodological developments and current tensions

    DEFF Research Database (Denmark)

    Roberts, Chris; Freeman, John; Samdal, Oddrun

    2009-01-01

    OBJECTIVES: To describe the methodological development of the HBSC survey since its inception and explore methodological tensions that need to be addressed in the ongoing work on this and other large-scale cross-national surveys. METHODS: Using archival data and conversations with members...... of the network, we collaboratively analysed our joint understandings of the survey's methodology. RESULTS: We identified four tensions that are likely to be present in upcoming survey cycles: (1) maintaining quality standards against a background of rapid growth, (2) continuous improvement with limited financial...... in working through such challenges renders it likely that HBSC can provide a model of other similar studies facing these tensions....

  3. Different Clinical Features and Lower Scores in Clinical Scoring Systems for Appendicitis in Preschool Children: Comparison with School Age Onset

    OpenAIRE

    Song, Chun Woo; Kang, Joon Won; Kim, Jae Young

    2018-01-01

    Purpose To clarify the clinical features of appendicitis in preschool children and to explore clinical appendicitis scoring systems in this age group. Methods We retrospectively collected data on 142 children, aged 10 years or younger, with confirmed diagnosis of appendicitis based on surgical and pathologic findings. Enrolled subjects were divided into two groups: Group 1 (preschool children aged ≤5 years, n=41) and Group 2 (school children aged >5 to ≤10 years, n=101). Data analyzed include...

  4. Clinicopathological and imaging features of breast cancer in Korean Women under 40 years of age

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jun Woo; Jang, Mi Jung; Kim, Sun Mi; Yun, Bo La; Lee, Jong Yoon; Kim, Eun Kyu; Kang, Eun Young; Park, So Yeon [Seoul National University Bundang Hospital, Seongnam (Korea, Republic of)

    2017-06-15

    To evaluate the clinicopathological and imaging features of mammography, ultrasonography, and magnetic resonance imaging (MRI) for breast cancer in Korean women under 40 years of age according to molecular subtypes. We included 183 breast cancers in 176 consecutive women under 40 years old who had been diagnosed with breast cancer between January 2012 and November 2014. The patients' clinical and pathologic records were available as electronic medical records. A retrospective review of the pre-operative imaging studies was performed with 177 mammographies, 183 ultrasonographies, and 178 MRIs. Eighty-six percent (158/183) of lesions were symptomatic, with masses (147/183) as the most common presentation. Eighty percent (22/25) of the asymptomatic lesions were diagnosed via screening ultrasonography. The luminal A subtype was the most common (n = 79, 43%), human epidermal growth factor receptor 2-enriched subtype showed indistinct margins on mammography (p = 0.006), the triple negative subtype depicted a posterior enhancement on ultrasonography (p < 0.001) and rim enhancement on MRI (p < 0.001). Breast cancers in Korean women under 40 years of age are commonly presented with a palpable mass, and luminal A is the most common molecular subtype. In our study, the imaging and pathologic characteristics of breast cancer in younger women were similar to those previously reported for older patients.

  5. Clinicopathological and imaging features of breast cancer in Korean Women under 40 years of age

    International Nuclear Information System (INIS)

    Kim, Jun Woo; Jang, Mi Jung; Kim, Sun Mi; Yun, Bo La; Lee, Jong Yoon; Kim, Eun Kyu; Kang, Eun Young; Park, So Yeon

    2017-01-01

    To evaluate the clinicopathological and imaging features of mammography, ultrasonography, and magnetic resonance imaging (MRI) for breast cancer in Korean women under 40 years of age according to molecular subtypes. We included 183 breast cancers in 176 consecutive women under 40 years old who had been diagnosed with breast cancer between January 2012 and November 2014. The patients' clinical and pathologic records were available as electronic medical records. A retrospective review of the pre-operative imaging studies was performed with 177 mammographies, 183 ultrasonographies, and 178 MRIs. Eighty-six percent (158/183) of lesions were symptomatic, with masses (147/183) as the most common presentation. Eighty percent (22/25) of the asymptomatic lesions were diagnosed via screening ultrasonography. The luminal A subtype was the most common (n = 79, 43%), human epidermal growth factor receptor 2-enriched subtype showed indistinct margins on mammography (p = 0.006), the triple negative subtype depicted a posterior enhancement on ultrasonography (p < 0.001) and rim enhancement on MRI (p < 0.001). Breast cancers in Korean women under 40 years of age are commonly presented with a palpable mass, and luminal A is the most common molecular subtype. In our study, the imaging and pathologic characteristics of breast cancer in younger women were similar to those previously reported for older patients

  6. A multidisciplinary systematic literature review on frailty: Overview of the methodology used by the Canadian Initiative on Frailty and Aging

    Directory of Open Access Journals (Sweden)

    Bergman Howard

    2009-10-01

    Full Text Available Abstract Background Over the past two decades, there has been a substantial growth in the body of literature on frailty in older persons. However, there is no consensus on its definition or the criteria used to identify frailty. In response to this lack of consensus, the Canadian Initiative on Frailty and Aging carried out a set of systematic reviews of the literature in ten areas of frailty research: biological basis; social basis; prevalence; risk factors; impact; identification; prevention and management; environment and technology; health services; health and social policy. This paper describes the methodology that was developed for the systematic reviews. Methods A Central Coordination Group (CCG was responsible for developing the methodology. This involved the development of search strategies and keywords, article selection processes, quality assessment tools, and guidelines for the synthesis of results. Each review was conducted by two experts in the content area, with the assistance of methodologists and statisticians from the CCG. Results Conducting a series of systematic literature reviews involving a range of disciplines on a concept that does not have a universally accepted definition posed several conceptual and methodological challenges. The most important conceptual challenge was determining what would qualify as literature on frailty. The methodological challenges arose from our goal of structuring a consistent methodology for reviewing literature from diverse fields of research. At the outset, certain methodological guidelines were deemed essential to ensure the validity of all the reviews. Nevertheless, it was equally important to permit flexibility in the application of the proposed methodology to capture the essence of frailty research within the given fields. Conclusion The results of these reviews allowed us to establish the status of current knowledge on frailty and promote collaboration between disciplines. Conducting

  7. Crack Growth-Based Predictive Methodology for the Maintenance of the Structural Integrity of Repaired and Nonrepaired Aging Engine Stationary Components

    National Research Council Canada - National Science Library

    Barron, Michael

    1999-01-01

    .... Specifically, the FAA's goal was to develop "Crack Growth-Based Predictive Methodologies for the Maintenance of the Structural Integrity of Repaired and Nonrepaired Aging Engine Stationary Components...

  8. Ageing study of the engineered safety features actuation system of the Loviisa NPP

    International Nuclear Information System (INIS)

    Simola, K.; Maskuniitty, M.

    1995-06-01

    An ageing study of the engineered safety features actuation system of the Loviisa nuclear power plant has been performed. The operating experience, including failure and maintenance histories of analog measuring devices, logics for safety signal formation and individual control electronics of pumps and valves, has been collected and analysed. The safety importance of system components has been studied with a fault tree analysis of a selected safety function. Based on the results of the analysis of operating experiences and the fault tree analysis, some components were selected for deeper analyses. According to the operating experience, the amount of failures in the Loviisa plant safety system has been low and no increasing trend in the failure history can yet be observed. Only a few failures had prohibited the propagation of the safety signal, mostly the failures have caused a false alarm. The failures reported have concerned mainly limit signal units, transmitters, and priority units. According to the fault tree analysis of one safety function, the most important components of this subsystem are individual control units and pulse/DC converters. Failure modes and effect analyses were performed for priority and individual control unit, limit signal unit and comparator and pulse/DC converter in order to identify the critical failure modes of these devices. (orig.) (15 refs., 26 figs., 9 tabs.)

  9. Age effect on components of episodic memory and feature binding: A virtual reality study.

    Science.gov (United States)

    Plancher, Gaën; Gyselinck, Valerie; Nicolas, Serge; Piolino, Pascale

    2010-05-01

    The aims were (1) to explore the effects of normal aging on the main aspects of episodic memory--what, where, and when,--and on feature binding in a virtual environment; (2) to explore the influence of the mode of learning, intentional versus incidental; and (3) to benchmark virtual environment findings collected with older adults against data recorded in classical neuropsychological tests. We tested a population of 82 young adults and 78 older adults without dementia (they participated in a short battery of neuropsychological tests). All the participants drove a car in an urban virtual environment composing of 9 turns and specific areas. Half of the participants were told to drive through the virtual town; the other half were asked to drive and to memorize the environment (itinerary, elements, etc.). All aspects of episodic memory were then assessed (what, where, when, and binding). The older participants had less recollection of the spatiotemporal context of events than the younger with intentional encoding (p episodic memory.

  10. Dante and cardiology: Physiopathology and clinical features of cardiovascular diseases in the Middle Ages.

    Science.gov (United States)

    Riva, M A; Cambioli, L; Castagna, F; Cianci, N; Varrenti, M; Giannattasio, C; Cesana, G

    2015-02-15

    Ancient non-medical texts can unexpectedly provide useful information on the development of knowledge about the heart and its diseases throughout history. The 750th anniversary of the birth of the Italian poet Dante Alighieri (1265-1321) provides a timely opportunity to analyze medical references in his works, in particular, focusing on literary descriptions that may be attributed to cardiovascular disorders. Dante's high level of medical knowledge, probably derived from his academic studies, is testified by his affiliation to the Florentine Guild of physicians and pharmacists. In all his works, the poet shows a deep interest for the heart. However, his anatomical and physiological knowledge of the circulatory system appears to be poor, probably due to it being based on theories and concepts brought forth by Aristotle and Galen, which were taught in medieval universities. Despite this, accurate descriptions of some symptoms (emotional syncope, orthopnea, dyspnea on exertion) and signs (ascites, paleness), which may be attributed to cardiovascular disorders, can be easily found in Dante's works, particularly in his masterpiece, the Divine Comedy. The literary and historical analysis of cardiovascular signs and symptoms allows us to assume that clinical features due to alterations of heart function were probably known by medieval physicians, but their etiology and pathophysiological mechanisms were not completely understood in that period. Historians of cardiology and clinicians should consider analysis of non-medical texts (including poetry) as an opportunity to better investigate the evolution of their discipline throughout the ages. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  11. Automated age-related macular degeneration classification in OCT using unsupervised feature learning

    Science.gov (United States)

    Venhuizen, Freerk G.; van Ginneken, Bram; Bloemen, Bart; van Grinsven, Mark J. J. P.; Philipsen, Rick; Hoyng, Carel; Theelen, Thomas; Sánchez, Clara I.

    2015-03-01

    Age-related Macular Degeneration (AMD) is a common eye disorder with high prevalence in elderly people. The disease mainly affects the central part of the retina, and could ultimately lead to permanent vision loss. Optical Coherence Tomography (OCT) is becoming the standard imaging modality in diagnosis of AMD and the assessment of its progression. However, the evaluation of the obtained volumetric scan is time consuming, expensive and the signs of early AMD are easy to miss. In this paper we propose a classification method to automatically distinguish AMD patients from healthy subjects with high accuracy. The method is based on an unsupervised feature learning approach, and processes the complete image without the need for an accurate pre-segmentation of the retina. The method can be divided in two steps: an unsupervised clustering stage that extracts a set of small descriptive image patches from the training data, and a supervised training stage that uses these patches to create a patch occurrence histogram for every image on which a random forest classifier is trained. Experiments using 384 volume scans show that the proposed method is capable of identifying AMD patients with high accuracy, obtaining an area under the Receiver Operating Curve of 0:984. Our method allows for a quick and reliable assessment of the presence of AMD pathology in OCT volume scans without the need for accurate layer segmentation algorithms.

  12. A systematic methodology for the robust quantification of energy efficiency at wastewater treatment plants featuring Data Envelopment Analysis.

    Science.gov (United States)

    Longo, S; Hospido, A; Lema, J M; Mauricio-Iglesias, M

    2018-05-10

    This article examines the potential benefits of using Data Envelopment Analysis (DEA) for conducting energy-efficiency assessment of wastewater treatment plants (WWTPs). WWTPs are characteristically heterogeneous (in size, technology, climate, function …) which limits the correct application of DEA. This paper proposes and describes the Robust Energy Efficiency DEA (REED) in its various stages, a systematic state-of-the-art methodology aimed at including exogenous variables in nonparametric frontier models and especially designed for WWTP operation. In particular, the methodology systematizes the modelling process by presenting an integrated framework for selecting the correct variables and appropriate models, possibly tackling the effect of exogenous factors. As a result, the application of REED improves the quality of the efficiency estimates and hence the significance of benchmarking. For the reader's convenience, this article is presented as a step-by-step guideline to guide the user in the determination of WWTPs energy efficiency from beginning to end. The application and benefits of the developed methodology are demonstrated by a case study related to the comparison of the energy efficiency of a set of 399 WWTPs operating in different countries and under heterogeneous environmental conditions. Copyright © 2018 Elsevier Ltd. All rights reserved.

  13. Features of high-speed and strength qualities development in young biathlonists aged 14–15 in the preparatory period

    Directory of Open Access Journals (Sweden)

    Artem Burla

    2015-04-01

    Full Text Available Purpose: to substantiate a methodology of high-speed and strength qualities development of young biathlonists aged 14–15 during the preparatory period. Material and Methods: young biathlonists aged 14–15 from control and experimental groups took part in the research. There were 12 athletes in each group. Pedagogical methods and methods of mathematical statistics were used in the work. Pedagogical methods of researches were used for level definition of high-speed and strength qualities development of young biathlonists. Results: reliable increase of motive qualities and polydynamometry results testing of young biathlonists from the experimental group due to implementation of the experimental methodology in the preparatory period is established. Conclusions: application of the developed complexes in the preparatory period in the experimental group of young biathlonists aged 14–15 allows to raise indices of motive qualities and polydynamometry testing statistically significantly.

  14. SU-D-204-01: A Methodology Based On Machine Learning and Quantum Clustering to Predict Lung SBRT Dosimetric Endpoints From Patient Specific Anatomic Features

    Energy Technology Data Exchange (ETDEWEB)

    Lafata, K; Ren, L; Wu, Q; Kelsey, C; Hong, J; Cai, J; Yin, F [Duke University Medical Center, Durham, NC (United States)

    2016-06-15

    Purpose: To develop a data-mining methodology based on quantum clustering and machine learning to predict expected dosimetric endpoints for lung SBRT applications based on patient-specific anatomic features. Methods: Ninety-three patients who received lung SBRT at our clinic from 2011–2013 were retrospectively identified. Planning information was acquired for each patient, from which various features were extracted using in-house semi-automatic software. Anatomic features included tumor-to-OAR distances, tumor location, total-lung-volume, GTV and ITV. Dosimetric endpoints were adopted from RTOG-0195 recommendations, and consisted of various OAR-specific partial-volume doses and maximum point-doses. First, PCA analysis and unsupervised quantum-clustering was used to explore the feature-space to identify potentially strong classifiers. Secondly, a multi-class logistic regression algorithm was developed and trained to predict dose-volume endpoints based on patient-specific anatomic features. Classes were defined by discretizing the dose-volume data, and the feature-space was zero-mean normalized. Fitting parameters were determined by minimizing a regularized cost function, and optimization was performed via gradient descent. As a pilot study, the model was tested on two esophageal dosimetric planning endpoints (maximum point-dose, dose-to-5cc), and its generalizability was evaluated with leave-one-out cross-validation. Results: Quantum-Clustering demonstrated a strong separation of feature-space at 15Gy across the first-and-second Principle Components of the data when the dosimetric endpoints were retrospectively identified. Maximum point dose prediction to the esophagus demonstrated a cross-validation accuracy of 87%, and the maximum dose to 5cc demonstrated a respective value of 79%. The largest optimized weighting factor was placed on GTV-to-esophagus distance (a factor of 10 greater than the second largest weighting factor), indicating an intuitively strong

  15. Frequency and Pattern of Documented Diagnostic Features and the Age of Autism Identification

    Science.gov (United States)

    Maenner, Matthew J.; Schieve, Laura A.; Rice, Catherine E.; Cunniff, Christopher; Giarelli, Ellen; Kirby, Russell S.; Lee, Li-Ching; Nicholas, Joyce S.; Wingate, Martha S.; Durkin, Maureen S.

    2013-01-01

    Objective: The "DSM-IV-TR" specifies 12 behavioral features that can occur in hundreds of possible combinations to meet diagnostic criteria for autism spectrum disorder (ASD). This paper describes the frequency and variability with which the 12 behavioral features are documented in a population-based cohort of 8-year-old children under…

  16. Engaging Focus Group Methodology: The 4-H Middle School-Aged Youth Learning and Leading Study

    Science.gov (United States)

    Scott, Siri; Grant, Samantha; Nippolt, Pamela Larson

    2015-01-01

    With young people, discussing complex issues such as learning and leading in a focus group can be a challenge. To help prime youth for the discussion, we created a focus group approach that featured a fun, interactive activity. This article includes a description of the focus group activity, lessons learned, and suggestions for additional…

  17. The Mediterranean diet and age-related cognitive functioning: A systematic review of study findings and neuropsychological assessment methodology.

    Science.gov (United States)

    Knight, Alissa; Bryan, Janet; Murphy, Karen

    2017-10-01

    The primary aims of this review were to identify studies investigating the association between the MedDiet pattern and age-related cognitive function, to determine the current status of knowledge, and to ascertain whether a lack of standardization with the operationalization of age-related cognitive function and differences in the chosen neuropsychological assessment methodology impacted on the results and findings. The systematic review protocol for this paper was carried out following the statement and general principles of PRISMA and the UK Centre for Reviews and Dissemination (CRD). A systematic search of electronic databases yielded two cross-sectional studies, two cross-sectional/prospective studies, and 11 prospective studies for inclusion. Among this group of studies, conflicting results and conclusions regarding the efficacy of the MedDiet as a therapeutic approach for age-related cognitive function were found. Of importance, clear differences among studies in relation to neuropsychological assessment methodology were identified. Such disparity appeared to be one plausible factor contributing to the lack of consensus among study findings. One of the important challenges for future research will be to aim toward some kind of standardized neuropsychological assessment criteria. This type of endeavor will enable the ability to validate with greater confidence, whether or not adherence to a MedDiet does promote benefit for age-related cognitive function.

  18. Core features of suicide. Gender, age, alcohol and other putative risk factors in a low-incidence population

    DEFF Research Database (Denmark)

    Stora, T.; Wang, August Gabriel

    2009-01-01

    25-64 years, unmarried, divorced and alcohol intoxicated. The main conclusion was that a low-incidence population of suicide population confirmed some supposed core features of the suicide phenomenon. Others, related to age and psychiatric disorders, were only partially confirmed. In periods...... of increase, the most vulnerable were the young and middle-aged males, unmarried, divorced, and alcohol played a crucial role Udgivelsesdato: 2008/11/10...

  19. Introduction to Visual Communication in the Age of Social Media: Conceptual, Theoretical and Methodological Challenges

    Directory of Open Access Journals (Sweden)

    Uta Russmann

    2017-12-01

    Full Text Available This thematic issue of Media and Communication focuses attention on the shift towards visual images on social media as well as the transformation of visual communication which has occurred within the online ecology of social media platforms. The sharing of images is becoming an integral part of the social media experience today, and given that social media platforms are the prime locus for sociability—at least among young people in the West—this shift towards visuals arguably transforms how we relate to each other and the world around us, as well as how we perceive and construct our sense of self. For researchers, this raises conceptual, theoretical and methodological challenges. This thematic issue presents six articles as well as a book review on visual communication in social media focusing on developing a conceptual apparatus and precise definitions of objects and practices of study as well as contributions that address and discuss the methodological challenges as well as their potential solutions. The idea was to synergize research from a wide variety of communication-related disciplines on this rather new topic.

  20. Teenagers' High Arrest Rates: Features of Young Age or Youth Poverty?

    Science.gov (United States)

    Males, Mike A.; Brown, Elizabeth A.

    2014-01-01

    The association of more crime with youthful age is widely accepted in social science. However, a literature search revealed no studies of the age-crime relationship that controlled for young ages' economic disadvantage. This research gap is addressed using the California Criminal Justice Statistics Center's arrest detail and Census poverty…

  1. Lifting the veil: a typological survey of the methodological features of Islamic ethical reasoning on biomedical issues.

    Science.gov (United States)

    Abdur-Rashid, Khalil; Furber, Steven Woodward; Abdul-Basser, Taha

    2013-04-01

    We survey the meta-ethical tools and institutional processes that traditional Islamic ethicists apply when deliberating on bioethical issues. We present a typology of these methodological elements, giving particular attention to the meta-ethical techniques and devices that traditional Islamic ethicists employ in the absence of decisive or univocal authoritative texts or in the absence of established transmitted cases. In describing how traditional Islamic ethicists work, we demonstrate that these experts possess a variety of discursive tools. We find that the ethical responsa-i.e., the products of the application of the tools that we describe-are generally characterized by internal consistency. We also conclude that Islamic ethical reasoning on bioethical issues, while clearly scripture-based, is also characterized by strong consequentialist elements and possesses clear principles-based characteristics. The paper contributes to the study of bioethics by familiarizing non-specialists in Islamic ethics with the role, scope, and applicability of key Islamic ethical concepts, such as "aims" (maqāṣid), "universals" (kulliyyāt), "interest" (maṣlaḥa), "maxims" (qawā`id), "controls" (ḍawābit), "differentiators" (furūq), "preponderization" (tarjīḥ), and "extension" (tafrī`).

  2. Prediction of troponin-T degradation using color image texture features in 10d aged beef longissimus steaks.

    Science.gov (United States)

    Sun, X; Chen, K J; Berg, E P; Newman, D J; Schwartz, C A; Keller, W L; Maddock Carlin, K R

    2014-02-01

    The objective was to use digital color image texture features to predict troponin-T degradation in beef. Image texture features, including 88 gray level co-occurrence texture features, 81 two-dimension fast Fourier transformation texture features, and 48 Gabor wavelet filter texture features, were extracted from color images of beef strip steaks (longissimus dorsi, n = 102) aged for 10d obtained using a digital camera and additional lighting. Steaks were designated degraded or not-degraded based on troponin-T degradation determined on d 3 and d 10 postmortem by immunoblotting. Statistical analysis (STEPWISE regression model) and artificial neural network (support vector machine model, SVM) methods were designed to classify protein degradation. The d 3 and d 10 STEPWISE models were 94% and 86% accurate, respectively, while the d 3 and d 10 SVM models were 63% and 71%, respectively, in predicting protein degradation in aged meat. STEPWISE and SVM models based on image texture features show potential to predict troponin-T degradation in meat. © 2013.

  3. A Feature Analysis of Risk Factors for Stroke in the Middle-Aged Adults

    OpenAIRE

    Haewon Byeon; Hyeung Woo Koh

    2015-01-01

    In order to maintain health during middle age and achieve successful aging, it is important to elucidate and prevent risk factors of middle-age stroke. This study investigated high risk groups of stroke in middle age population of Korea and provides basic material for establishment of stroke prevention policy by analyzing sudden perception of speech/language problems and clusters of multiple risk factors. This study analyzed 2,751 persons (1,191 males and 1,560 females) aged 40–59 who partici...

  4. Application of the RES methodology for identifying features, events and processes (FEPs) for near-field analysis of copper-steel canister

    International Nuclear Information System (INIS)

    Vieno, T.; Hautojaervi, A.; Raiko, H.; Ahonen, L.; Salo, J.P.

    1994-12-01

    Rock Engineering Systems (RES) is an approach to discover the important characteristics and interactions of a complex problem. Recently RES has been applied to identify features, events and processes (FEPs) for performance analysis of nuclear waste repositories. The RES methodology was applied to identify FEPs for the near-field analysis of the copper-steel canister for spent fuel disposal. The aims of the exercise were to learn and test the RES methodology and, secondly, to find out how much the results differ when RES is applied by two different groups on the same problem. A similar exercise was previously carried out by a SKB group. A total of 90 potentially significant FEPs were identified. The exercise showed that the RES methodology is a practicable tool to get a comprehensive and transparent picture of a complex problem. The approach is easy to learn and use. It reveals the important characteristics and interactions and organizes them in a format easy to understand. (9 refs., 5 figs., 3 tabs.)

  5. Improving methodological strategies for statellite cells counting in human muscle during ageing

    Czech Academy of Sciences Publication Activity Database

    Sajko, Š.; Kubínová, Lucie; Kreft, M.; Dahmane, R.; Wernig, A.; Eržen, I.

    2002-01-01

    Roč. 21, č. 1 (2002), s. 7-12 ISSN 1580-3139 Grant - others:European programme(XE) QLKG-1999-02034 Institutional research plan: CEZ:AV0Z5011922 Keywords : ageing * immunohistochemistry * satellite cell s Subject RIV: EA - Cell Biology

  6. Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease: Methodology and Baseline Sample Characteristics.

    Science.gov (United States)

    Byun, Min Soo; Yi, Dahyun; Lee, Jun Ho; Choe, Young Min; Sohn, Bo Kyung; Lee, Jun-Young; Choi, Hyo Jung; Baek, Hyewon; Kim, Yu Kyeong; Lee, Yun-Sang; Sohn, Chul-Ho; Mook-Jung, Inhee; Choi, Murim; Lee, Yu Jin; Lee, Dong Woo; Ryu, Seung-Ho; Kim, Shin Gyeom; Kim, Jee Wook; Woo, Jong Inn; Lee, Dong Young

    2017-11-01

    The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's disease (KBASE) aimed to recruit 650 individuals, aged from 20 to 90 years, to search for new biomarkers of Alzheimer's disease (AD) and to investigate how multi-faceted lifetime experiences and bodily changes contribute to the brain changes or brain pathologies related to the AD process. All participants received comprehensive clinical and neuropsychological evaluations, multi-modal brain imaging, including magnetic resonance imaging, magnetic resonance angiography, [ 11 C]Pittsburgh compound B-positron emission tomography (PET), and [ 18 F]fluorodeoxyglucose-PET, blood and genetic marker analyses at baseline, and a subset of participants underwent actigraph monitoring and completed a sleep diary. Participants are to be followed annually with clinical and neuropsychological assessments, and biannually with the full KBASE assessment, including neuroimaging and laboratory tests. As of March 2017, in total, 758 individuals had volunteered for this study. Among them, in total, 591 participants-291 cognitively normal (CN) old-aged individuals, 74 CN young- and middle-aged individuals, 139 individuals with mild cognitive impairment (MCI), and 87 individuals with AD dementia (ADD)-were enrolled at baseline, after excluding 162 individuals. A subset of participants (n=275) underwent actigraph monitoring. The KBASE cohort is a prospective, longitudinal cohort study that recruited participants with a wide age range and a wide distribution of cognitive status (CN, MCI, and ADD) and it has several strengths in its design and methodologies. Details of the recruitment, study methodology, and baseline sample characteristics are described in this paper.

  7. How Transferable are CNN-based Features for Age and Gender Classification?

    OpenAIRE

    Özbulak, Gökhan; Aytar, Yusuf; Ekenel, Hazım Kemal

    2016-01-01

    Age and gender are complementary soft biometric traits for face recognition. Successful estimation of age and gender from facial images taken under real-world conditions can contribute improving the identification results in the wild. In this study, in order to achieve robust age and gender classification in the wild, we have benefited from Deep Convolutional Neural Networks based representation. We have explored transferability of existing deep convolutional neural network (CNN) models for a...

  8. Methodological study of aging effects on fuel cells using X-ray synchrotron radiography and tomography

    International Nuclear Information System (INIS)

    Arlt, Tobias

    2012-01-01

    In the present work, new and advanced methods for the investigation of methanol and hydrogen powered fuel cells were analyzed. Synchrotron radiography and tomography were applied to investigate materials and transport processes in operating fuel cells ''in-situ'' and non-destructively. The corrosion of ruthenium is a key issue during aging of direct methanol fuel cells (DMFC). Therefore the influence of different aging processes on the distribution of ruthenium is of great interesting. An imaging method based on X-ray absorption spectroscopy (XAS) was applied to investigate the changes in the distribution of fuel cell catalysts three-dimensionally. Using monoenergetic synchrotron radiation it was shown that the distribution of ruthenium (Ru) in the anode catalyst changes after application of an accelerated aging procedure. A strong influence on the flowfield and the gas diffusion layer structures on the Ru distribution were found in the gas diffusion electrode at the anode side. Additionally some ruthenium moves through the membrane from the anode to the cathode. The redistribution caused by the accelerated aging procedure strongly differs from that obtained after aging under realistic stack operation (here over 1700 h) of a fuel cell in a pallet transporter. For the tomographic investigations samples were taken out from a stack operation in aged membrane electrode assembly (MEA) and were analyzed ex-situ. It was shown that the Ru redistribution can be attributed to mass transport processes (CO 2 and H 2 O) in the gas diffusion layer (GDL). Other high energy resolved measurements showed that the strength of the oxidation of ruthenium and platinum depends on the spatial distribution of the ruthenium. Last mentioned - also for the platinum catalyst - could be given quantitatively by means of this newly developed method. In the second part of this work high temperature polymer electrolyte fuel cells (HT-PEFC) were investigated. No liquid water can

  9. The structural aging assessment program: ranking methodology for CANDU nuclear generating station concrete components

    International Nuclear Information System (INIS)

    Philipose, K.E.; Muhkerjee, P.K.; McColm, E.J.

    1997-01-01

    Most of the major structural components in CANDU nuclear generating stations are constructed of reinforced concrete. Although passive in nature, these structures perform many critical safety functions in the operation of each facility. Aging can affect the structural capacity and integrity of structures. The reduction in capacity due to aging is not addressed in design codes. Thus a program is warranted to monitor the aging of safety-related CANDU plant structures and to prioritize those that require maintenance and repairs. Prioritization of monitoring efforts is best accomplished by focusing on those structures judged to be the most critical to plant performance and safety. The safety significance of each sub-element and its degradation with time can be evaluated using a numerical rating system. This will simplify the utility's efforts, thereby saving maintenance costs while providing a higher degree of assurance that performance is maintained. This paper describes the development of a rating system (ranking procedure) as part of the Plant Life Management of CANDU generating station concrete structures and illustrates its application to an operating plant. (author)

  10. A methodological approach to studying resilience mechanisms: demonstration of utility in age and Alzheimer's disease-related brain pathology.

    Science.gov (United States)

    Wolf, Dominik; Fischer, Florian Udo; Fellgiebel, Andreas

    2018-05-01

    The present work aims at providing a methodological approach for the investigation of resilience factors and mechanisms in normal aging, Alzheimer's disease (AD) and other neurodegenerative disorders. By expanding and re-conceptualizing traditional regression approaches, we propose an approach that not only aims at identifying potential resilience factors but also allows for a differentiation between general and dynamic resilience factors in terms of their association with pathology. Dynamic resilience factors are characterized by an increasing relevance with increasing levels of pathology, while the relevance of general resilience factors is independent of the amount of pathology. Utility of the approach is demonstrated in age and AD-related brain pathology by investigating widely accepted resilience factors, including education and brain volume. Moreover, the approach is used to test hippocampal volume as potential resilience factor. Education and brain volume could be identified as general resilience factors against age and AD-related pathology. Beyond that, analyses highlighted that hippocampal volume may not only be disease target but also serve as a potential resilience factor in age and AD-related pathology, particularly at higher levels of tau-pathology (i.e. dynamic resilience factor). Given its unspecific and superordinate nature the approach is suitable for the investigation of a wide range of potential resilience factors in normal aging, AD and other neurodegenerative disorders. Consequently, it may find a wide application and thereby promote the comparability between studies.

  11. Hypertension Is a Key Feature of the Metabolic Syndrome in Subjects Aging with HIV

    DEFF Research Database (Denmark)

    Martin-Iguacel, Raquel; Negredo, Eugènia; Peck, Robert

    2016-01-01

    to predispose to these metabolic complications and to the excess risk of CVD observed in the HIV population. The metabolic syndrome (MS) represents a clustering of RF for CVD that includes abdominal obesity, hypertension, dyslipidemia and insulin resistance. Hypertension is a prevalent feature of the MS in HIV...

  12. Age and Sex Effects in Anchoring Vignette Studies: Methodological and Empirical Contributions

    Directory of Open Access Journals (Sweden)

    Hanna Grol-Prokopczyk

    2013-04-01

    Full Text Available Anchoring vignettes are an increasingly popular tool for identifying and correcting for group differences in use of subjective ordered response categories. However, existing techniques to maximize response consistency (use of the same standards for self-ratings as for vignette-ratings, which center on matching vignette characters’ demographic characteristics to respondents’ own characteristics, appear at times to be ineffective or to pose interpretive difficulties. Specifically, respondents often appear to neglect instructions to treat vignette characters as age peers. Furthermore, when vignette characters’ sex is matched to respondents’ sex, interpretation of sex differences in rating style is rendered problematic. This study applies two experimental manipulations to a national American sample (n=1,765 to clarify best practices for enhancing response consistency. First, an analysis of two methods of highlighting vignette characters’ age suggests that both yield better response consistency than previous, less prominent means. Second, a comparison of ratings of same- and opposite-sex vignette characters suggests that, with avoidable exceptions, the sex of the respondent rather than of the vignette character drives observed sex differences in rating style. Implications for interpretation and design of anchoring vignette studies are discussed. Findings also show significant sex, educational, and racial/ethnic differences in styles of rating health, and racial/ethnic differences in styles of rating political efficacy. These findings underscore the incomparability of unadjusted subjective self-ratings across demographic groups.

  13. Computed tomographic features of the feline brain change with advancing age?

    Directory of Open Access Journals (Sweden)

    Viviam R. Babicsak

    2015-12-01

    Full Text Available Abstract: A better understanding of normal or expected encephalic changes with increasing age in cats is needed as a growing number of these animals is attended in veterinary clinics, and imaging data referring to normal age-associated changes are extremely scarce in the literature. The objective of this study was to identify age-related changes in feline brain using CT imaging. Fifteen non-brachycephalic healthy cats with age between 1 to 6 years (adult group and others over 12 years (geriatric group were submitted to CT scan of the brain. Statistically significant differences were found between the groups for the ability to identify the left lateral ventricle and for falx cerebri calcification, both identified in a greater number of cats of the geriatric group. A significantly higher mean width of the third ventricle was also detected in geriatric animals. There were no statistically significant differences between lateral ventricular dimensions and encephalic parenchymal attenuation on pre and post-contrast CT phases. The results of the present study show an increase in the incidence of falx cerebri calcification and a third ventricular dilatation with advancing age in cats. Future researches using MRI scanners and a greater quantity of cats are needed in order to identify supplementary age-related changes.

  14. Core features of suicide. Gender, age, alcohol and other putative risk factors in a low-incidence population

    DEFF Research Database (Denmark)

    Wang, August G; Stórá, Tormódur

    2009-01-01

    The aim of the study was to elucidate some supposed core features of suicide through a study of suicide in a low-incidence population. The material covered all suicides and undetermined deaths 1945-2004 in the Faroe Islands (a low-incidence population) and the study made use of all available...... information. Results showed that suicide rate had been low since the Second World War. However, there was an increase throughout the 1970s and 1980s. Supposed core features of suicide, such as gender, marital status, former psychiatric admittance, former suicidal behaviour, alcohol and method preference were...... 25-64 years, unmarried, divorced and alcohol intoxicated. The main conclusion was that a low-incidence population of suicide population confirmed some supposed core features of the suicide phenomenon. Others, related to age and psychiatric disorders, were only partially confirmed. In periods...

  15. Comparative Study of Features of Social Intelligence and Speech Behavior of Children of Primary School Age with Impaired Mental Function

    Directory of Open Access Journals (Sweden)

    Shcherban D.

    2018-04-01

    Full Text Available The article discusses the concept of social intelligence and its characteristics in children of primary school age with impaired mental functions. The concept and main features, including speech, are discussed, delays of mental development, the importance of detained development for social intelligence and speech behavior are also considered. Also, the concept of speech behavior is analyzed, the author defines the phenomenon, describes its specific features, which are distinguish its structure, and consist of six components: verbal, emotional, motivational, ethical (moral, prognostic, semantic (cognitive. Particular attention is paid to the position of social intelligence in the structure of speech behavior of children of primary school age with a impaired mental functions. Indicators of social intelligence were analyzed from the point of view of speech behavior of children with different rates of mental development and compared with its components at a qualitative level. The study used both author's and well-known techniques.

  16. FEATURES OF THE USE OF INTERNATIONALISM IN THE LITERATURE OF THE EMIGRANT WRITERS IN THE AGE OF GLOBALIZATION

    Directory of Open Access Journals (Sweden)

    2013-02-01

    Full Text Available In this article the features of the use of internationalism in the literature of emigrants are considered. The functioning of international lexicon is considered at the present stage of development in the age of globalization. In the article the terms "Sovietism" and "internationalism " are analyzed and differentiated. Characteristic features of these terms are considered. Special attention is given to internationalism of the Soviet era. There is the analysis of changes in the associations, stylistic nuance and emotional assessment by examples of the Soviet internationalism in the literature of emigrants in the age of globalization. The received results can be used in making of dictionary of Sovietism, development of the programs for lexicon and stylistics study.

  17. FEATURES OF THE USE OF INTERNATIONALISM IN THE LITERATURE OF THE EMIGRANT WRITERS IN THE AGE OF GLOBALIZATION

    Directory of Open Access Journals (Sweden)

    Мария Игоревна Шкредова

    2013-04-01

    Full Text Available In this article the features of the use of internationalism in the literature of emigrants are considered. The functioning of international lexicon is considered at the present stage of development in the age of globalization. In the article the terms "Sovietism" and "internationalism " are analyzed and differentiated. Characteristic features of these terms are considered. Special attention is given to internationalism of the Soviet era. There is the analysis of changes in the associations, stylistic nuance and emotional assessment by examples of the Soviet internationalism in the literature of emigrants in the age of globalization.The received results can be used in making of dictionary of Sovietism, development of the programs for lexicon and stylistics study.DOI: http://dx.doi.org/10.12731/2218-7405-2013-2-41

  18. Optimized maintenance concept of safety relevant valves related to ageing management features in nuclear power plants

    International Nuclear Information System (INIS)

    Koring, R.

    2007-01-01

    This paper presents the existing concept in E.ON Kernkraft and its sound application to ageing management issues by focussing on group 2 components such as safety relevant valves. It is demonstrated how the maintenance concept of safety relevant valves is supported by a valve diagnostic system accompanied by an applied procedure to assess the measured results with respect to the required functionality and ageing phenomena. Furthermore this concept has been developed to optimize the existing preventive maintenance of the safety relevant valves by implementing condition oriented aspects derived from the diagnostic results. The main issue of this maintenance concept is to demonstrate the high level of the secured function, reliability and performance of the safety relevant valves within an integrated ageing management. Additionally it offers improvements of all preventive maintenance issues as maintenance periods and the component related volume, spare parts management and costs. (author)

  19. Morphology of the human atrioventricular node is age dependent: a feature of potential clinical significance

    NARCIS (Netherlands)

    Waki, K.; Kim, J. S.; Becker, A. E.

    2000-01-01

    Advances in catheter ablation procedures have created the need to understand better the morphology of the AV node (AVN), particularly as it relates to age. This study was based on 40 normally structured hearts obtained at autopsy from patients without a history of tachyarrhythmia in the following

  20. Low back pain in school-age children: risk factors, clinical features and diagnostic managment.

    Science.gov (United States)

    Boćkowski, L; Sobaniec, W; Kułak, W; Smigielska-Kuzia, J; Sendrowski, K; Roszkowska, M

    2007-01-01

    Low back pain (LBP) is common in adult population, and it is becoming a serious health concern in adolescents. On surveys, about every fifth child in the school-age reports LBP. The study objective was to analysis the natural history, risk factors, clinical symptoms, causes and diagnostic management in school-age children hospitalized with LBP. The study group consisted of 36 patients at the age between 10 and 18 years, 22 girls and 14 boys suffering from LBP hospitalized in our Department of Pediatric Neurology and Rehabilitation in years 2000-2004. The mean age of clinical onset of LBP in our group was 14.7 years, earlier in girls, later in boys. We find the family history of LBP in 50% children. Most frequent factors associated with LBP were: spina bifida (16.7%) and incorrect posture (13.9%). Half of patients pointed the factor initialising LBP: rapid, incoordinated move (39%) or heavy load rise (11%). 58% of patients present the symptoms of ischialgia. Diagnostic imaging showed disc protrusion in 11 children (31%) 6 in computed tomography, 4 in magnetic resonance imaging and 1 in X-Ray examination only. Other causes of LBP included: spondylolysis in 2 patients, Scheuermann disease in one case and juvenile reumatoid arthritis in one case. Some school-age children suffering on low back pain, particulary with sciatic neuralgia symptoms seek medical care in hospital. Althought the main causes are mechanical, associated with lack of physical activity or strenous exercise, serious diagnostic managment is strongly recommended.

  1. Feature-selective attention: evidence for a decline in old age.

    Science.gov (United States)

    Quigley, Cliodhna; Andersen, Søren K; Schulze, Lars; Grunwald, Martin; Müller, Matthias M

    2010-04-19

    Although attention in older adults is an active research area, feature-selective aspects have not yet been explicitly studied. Here we report the results of an exploratory study involving directed changes in feature-selective attention. The stimuli used were two random dot kinematograms (RDKs) of different colours, superimposed and centrally presented. A colour cue with random onset after the beginning of each trial instructed young and older subjects to attend to one of the RDKs and detect short intervals of coherent motion while ignoring analogous motion events in the non-cued RDK. Behavioural data show that older adults could detect motion, but discriminated target from distracter motion less reliably than young adults. The method of frequency tagging allowed us to separate the EEG responses to the attended and ignored stimuli and directly compare steady-state visual evoked potential (SSVEP) amplitudes elicited by each stimulus before and after cue onset. We found that younger adults show a clear attentional enhancement of SSVEP amplitude in the post-cue interval, while older adults' SSVEP responses to attended and ignored stimuli do not differ. Thus, in situations where attentional selection cannot be spatially resolved, older adults show a deficit in selection that is not shared by young adults. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

  2. AVISE, ageing anticipation methodology using expert judgement and stimulation. Application to a nuclear power plant component: the pressurizer

    International Nuclear Information System (INIS)

    Bouzaiene-Marle, L.

    2005-04-01

    This thesis deals with components ageing anticipation in the context of life cycle management. The proposed approach, called AVISE, allows the identification of potentials problems related to ageing, to measure the risks in terms of degradation probability and degradation consequences and gives the adequate solutions to stop or to postpone ageing. This research was undertaken in a particular industrial context, the nuclear industry. Equipments used in this context are specific and particularly reliable. These characteristics result in limited feedback (low number of failures). To compensate for this limited information, two solutions are proposed in this approach. The first solution that we can consider as a classical one consists in using expert judgement. The second one, more original, consists in using the operation feedback of 'similar' components. In order to apply these solutions and to obtain the anticipation results, a set of methodological tools was developed and tested in a real industrial application on a nuclear power plant component: the pressurizer. The first tool is a generic process for expert judgement, identified thanks to a comparison between eleven existing methods using expert judgement. Two methods based on expert stimulation and called STIMEX-IMDP and STIMEX-IPP were elaborated. A reference list of degradation mechanisms and a reference list of ageing effects were constructed and used in the method STIMEX-IMDP in order to help expert stimulation. Then, the developed approach proposes the use of belief networks to model and quantify the risks related to the potential degradations. Finally, the construction of a conceptual data model and specifications are given for the creation of an ageing database. The data to capitalize was identified on the basis of the research undertaken in this thesis. (author)

  3. Towards A Model-based Prognostics Methodology for Electrolytic Capacitors: A Case Study Based on Electrical Overstress Accelerated Aging

    Directory of Open Access Journals (Sweden)

    Gautam Biswas

    2012-12-01

    Full Text Available This paper presents a model-driven methodology for predict- ing the remaining useful life of electrolytic capacitors. This methodology adopts a Kalman filter approach in conjunction with an empirical state-based degradation model to predict the degradation of capacitor parameters through the life of the capacitor. Electrolytic capacitors are important components of systems that range from power supplies on critical avion- ics equipment to power drivers for electro-mechanical actuators. These devices are known for their comparatively low reliability and given their critical role in the system, they are good candidates for component level prognostics and health management. Prognostics provides a way to assess remain- ing useful life of a capacitor based on its current state of health and its anticipated future usage and operational conditions. This paper proposes and empirical degradation model and discusses experimental results for an accelerated aging test performed on a set of identical capacitors subjected to electrical stress. The data forms the basis for developing the Kalman-filter based remaining life prediction algorithm.

  4. FEATURES OF INTERCONNECTION OF SELF-ESTEEM AND ANXIETY IN THE YOUNGER SCHOOL AGE

    OpenAIRE

    Калюжна, Євгенія; Шевергіна, Марія

    2015-01-01

     The article is devoted the phenomenology of anxiety and self-esteem of personality and the nature their interconnection in the younger school age. Is emphasized that self-esteem and anxiety are complex personal formations, which belong to basic personality traits. The importance of self-esteem as a component of core of personality and the important regulator of social activity. Substantiated the thesis that self-esteem is the result of comparing the person’s qualities with social relevant st...

  5. Age at onset of major depressive disorder in Han Chinese women: Relationship with clinical features and family history☆

    Science.gov (United States)

    Yang, Fuzhong; Li, Yihan; Xie, Dong; Shao, Chunhong; Ren, Jianer; Wu, Wenyuan; Zhang, Ning; Zhang, Zhen; Zou, Ying; Zhang, Jiulong; Qiao, Dongdong; Gao, Chengge; Li, Youhui; Hu, Jian; Deng, Hong; Wang, Gang; Du, Bo; Wang, Xumei; Liu, Tiebang; Gan, Zhaoyu; Peng, Juyi; Wei, Bo; Pan, Jiyang; Chen, Honghui; Sun, Shufan; Jia, Hong; Liu, Ying; Chen, Qiaoling; Wang, Xueyi; Cao, Juling; Lv, Luxian; Chen, Yunchun; Ha, Baowei; Ning, Yuping; Chen, YiPing; Kendler, Kenneth S.; Flint, Jonathan; Shi, Shenxun

    2011-01-01

    Background Individuals with early-onset depression may be a clinically distinct group with particular symptom patterns, illness course, comorbidity and family history. This question has not been previously investigated in a Han Chinese population. Methods We examined the clinical features of 1970 Han Chinese women with DSM-IV major depressive disorder (MDD) between 30 and 60 years of age across China. Analysis of linear, logistic and multiple logistic regression models was used to determine the association between age at onset (AAO) with continuous, binary and discrete characteristic clinical features of MDD. Results Earlier AAO was associated with more suicidal ideation and attempts and higher neuroticism, but fewer sleep, appetite and weight changes. Patients with an earlier AAO were more likely to suffer a chronic course (longer illness duration, more MDD episodes and longer index episode), increased rates of MDD in their parents and a lower likelihood of marriage. They tend to have higher comorbidity with anxiety disorders (general anxiety disorder, social phobia and agoraphobia) and dysthymia. Conclusions Early AAO in MDD may be an index of a more severe, highly comorbid and familial disorder. Our findings indicate that the features of MDD in China are similar to those reported elsewhere in the world. PMID:21782247

  6. Age at onset of major depressive disorder in Han Chinese women: relationship with clinical features and family history.

    Science.gov (United States)

    Yang, Fuzhong; Li, Yihan; Xie, Dong; Shao, Chunhong; Ren, Jianer; Wu, Wenyuan; Zhang, Ning; Zhang, Zhen; Zou, Ying; Zhang, Jiulong; Qiao, Dongdong; Gao, Chengge; Li, Youhui; Hu, Jian; Deng, Hong; Wang, Gang; Du, Bo; Wang, Xumei; Liu, Tiebang; Gan, Zhaoyu; Peng, Juyi; Wei, Bo; Pan, Jiyang; Chen, Honghui; Sun, Shufan; Jia, Hong; Liu, Ying; Chen, Qiaoling; Wang, Xueyi; Cao, Juling; Lv, Luxian; Chen, Yunchun; Ha, Baowei; Ning, Yuping; Chen, Yiping; Kendler, Kenneth S; Flint, Jonathan; Shi, Shenxun

    2011-12-01

    Individuals with early-onset depression may be a clinically distinct group with particular symptom patterns, illness course, comorbidity and family history. This question has not been previously investigated in a Han Chinese population. We examined the clinical features of 1970 Han Chinese women with DSM-IV major depressive disorder (MDD) between 30 and 60 years of age across China. Analysis of linear, logistic and multiple logistic regression models was used to determine the association between age at onset (AAO) with continuous, binary and discrete characteristic clinical features of MDD. Earlier AAO was associated with more suicidal ideation and attempts and higher neuroticism, but fewer sleep, appetite and weight changes. Patients with an earlier AAO were more likely to suffer a chronic course (longer illness duration, more MDD episodes and longer index episode), increased rates of MDD in their parents and a lower likelihood of marriage. They tend to have higher comorbidity with anxiety disorders (general anxiety disorder, social phobia and agoraphobia) and dysthymia. Early AAO in MDD may be an index of a more severe, highly comorbid and familial disorder. Our findings indicate that the features of MDD in China are similar to those reported elsewhere in the world. Copyright © 2011 Elsevier B.V. All rights reserved.

  7. Special feature article. Nuclear new age. Towards reform of laws and regulations

    International Nuclear Information System (INIS)

    Madarame, Haruki; Morokuzu, Muneo; Shiroyama, Hideaki; Nishiwaki, Yoshihiro; Marumo, Syunji; Suzuki, Takahiro; Hariyama, Hideo

    2007-01-01

    Since about half a century passes after the peaceful use of nuclear energy began in Japan, the safety laws and regulations of the nuclear energy becomes difficult to cope enough with the current situation without regulation structure changing. In March 2007, Tokyo University set up nuclear energy legislation study meeting' consisting of members from regulatory bodies, electric utilities, nuclear industries and others. The special feature introduces five opinions obtained through the argument in the meeting. As an example, Law for the Regulations of Nuclear Sources Material, Nuclear Fuel Material and Reactors is applied to basic design about the commercial reactors, but Electric Utilities Industry Law is applied to a detailed design, and different licensing standard is applied in each. Taking the adjustment of licensing standard with unifying these is necessary for efficiency. In addition, current law for the Regulations of Nuclear Sources Material, Nuclear Fuel Material and Reactors regulates according to the businesses such as reactor facilities, fuel fabrication plants and radioactive waste disposal. As for plural businesses, a low procedure and safety measures are demanded every each business. It is also necessary to include structure of the comprehensive licensing that assumed an enterprise running plural businesses. (T. Tanaka)

  8. Features of dynamic strain aging in high strength Al-Zn-Mg-Cu alloy

    Energy Technology Data Exchange (ETDEWEB)

    Peng Kaiping; Chen Wenzhe; Zhang Haoguo; Qian Kuangwu [Fuzhou Univ., Fujian (China)

    1997-08-30

    The present work investigates mainly the regulation and features of the occurrence of serrated yielding phenomenon of a high strength Al-Zn-Mg-Cu alloy LC4 under various heat treatments and loading conditions. The main results are: (1) In the serrated yielding temperature region a critical transition temperature T{sub t} exists. The critical plastic strain has a negative or positive temperature coefficient within the temperature region lower or higher than T{sub t}; (2) The reason for this phenomenon might be the existence of an absorbed resource which diminishes the pinning effect of solute atoms to mobile dislocations; (3) in the positive coefficient region two reverse thermal activation processes occur simultaneously. One is the solute atoms diffuse to the moving dislocations and pin the dislocations. The other one is the absorbed resource absorbs the solute and diminishes the pinning effect; (4) for LC4, the activation energy of the first process is equivalent to the diffusion activation energy of Mg in Al matrix and the second one is equivalent to that of the interface absorbed solute atoms. (orig.) 6 refs.

  9. GENDER FEATURES OF THE ATTITUDE TOWARDS HEALTH OF PERSONS OF MATURE AGE

    Directory of Open Access Journals (Sweden)

    T. V. Mayasova

    2016-01-01

    Full Text Available In article the attitude towards health and a healthy lifestyle at men and women of middle age is investigated. One of the main problems which exist in our society, the problem of the passive or indifferent attitude towards the health of adults is. Other important problem is that the value of health becomes more tool and its value as means to live long and fully is lost. Installations and representations of the person about health depend on conditions of socialization of the person, including on gender (polorolevykh stereotypes and expectations, characteristic for concrete society and culture. The analysis of the results received during empirical research confirms that there are certain divergences in the attitude towards health at men and women. Reliable distinctions of valuable orientation concerning a healthy lifestyle at men and women are revealed. Statistically reliable distinctions in men's and women's groups concerning the factors influencing health of the person are defined

  10. Features of competition and development of markets in an age of globalized economy

    Directory of Open Access Journals (Sweden)

    Dr.Sc. Skender Kërçuku

    2011-12-01

    Full Text Available The fall of communism in Eastern Europe in the beginning of the 90-ies of the 20th century marked the beginning of a historical process of triumph of market economy in a wide geographical area and a large population, which had to have an influence on global developments. This age is characterized not only by a comprehensive ruling of capitalist market economy, but also by a series of important structural changes in economies of various countries, national and international mechanisms of market functioning, and relevant institutions thereto. Distinct authors have various opinions on characteristics and positive and negative outcomes of a globalized economy era. Some consider the globalization of world economy as a quantitative and qualitative expansion of market economy throughout the world, similar to the situation before the World War I. Other more serious authors consider the globalization of world economy as a new qualitative era, with important consequences on many areas.

  11. Towards A Model-based Prognostics Methodology for Electrolytic Capacitors: A Case Study Based on Electrical Overstress Accelerated Aging

    Data.gov (United States)

    National Aeronautics and Space Administration — A remaining useful life prediction methodology for elec- trolytic capacitors is presented. This methodology adopts a Kalman filter approach in conjunction with an...

  12. Towards A Model-Based Prognostics Methodology For Electrolytic Capacitors: A Case Study Based On Electrical Overstress Accelerated Aging

    Data.gov (United States)

    National Aeronautics and Space Administration — This paper presents a model-driven methodology for predict- ing the remaining useful life of electrolytic capacitors. This methodology adopts a Kalman filter...

  13. Making rainfall features fun: scientific activities for teaching children aged 5-12 years

    Science.gov (United States)

    Gires, Auguste; Muller, Catherine L.; le Gueut, Marie-Agathe; Schertzer, Daniel

    2016-05-01

    Research projects now rely on an array of different channels to increase impact, including high-level scientific output, tools, and equipment, but also communication, outreach, and educational activities. This paper focuses on education for children aged 5-12 years and presents activities that aim to help them (and their teachers) grasp some of the complex underlying issues in environmental science. More generally, it helps children to become familiarized with science and scientists, with the aim to enhance scientific culture and promote careers in this field. The activities developed are focused on rainfall: (a) designing and using a disdrometer to observe the variety of drop sizes; (b) careful recording of successive dry and rainy days and reproducing patterns using a simple model based on fractal random multiplicative cascades; and (c) collaboratively writing a children's book about rainfall. These activities are discussed in the context of current state-of-the-art pedagogical practices and goals set by project funders, especially in a European Union framework.

  14. The Gañuelas-Mazarrón Tertiary Basin (Murcia, Spain): Features, Analogies, implications for the Safety of a CO2-DGS and Methodology

    International Nuclear Information System (INIS)

    Rodrigo-Naharro, J.; Clemente-Jul, C.; Pérez del Villar, L.

    2015-01-01

    This work summarizes the main features of the Gañuelas-Mazarrón Tertiary basin, emphasising on the: i) geological, hydrogeological and hydrogeochemical characteristics; ii) current carbonate precipitation related to waters from several hydrogeological and geothermal wells in the basin; and iii) dissolved and free CO2 leakages and associated gases, mainly 222Rn. Furthermore, it has been summarised the main analogies established between the natural system studied and a CO2-Deep Geological Storage (CO2-DGS) conceptual model; as well as the implications of these analogies to qualitatively analyse the behaviour and evaluate the safety, in short, medium and long term, of a CO2-DGS. Finally, a useful methodology for any sedimentary basin, similar to the Gañuelas-Mazarrón basin, capable to host a CO2-DGS is also proposed. In conclusion, the full or partial study of a natural system analogous to a CO2-DGS must not be confused with the study to characterise a site for a CO2-DGS, since natural analogues should provide information about the behaviour, evolution and safety, in long-term, of the natural system, and that this information could be applied to a CO2-DGS system.

  15. Odor valence linearly modulates attractiveness, but not age assessment, of invariant facial features in a memory-based rating task.

    Science.gov (United States)

    Seubert, Janina; Gregory, Kristen M; Chamberland, Jessica; Dessirier, Jean-Marc; Lundström, Johan N

    2014-01-01

    Scented cosmetic products are used across cultures as a way to favorably influence one's appearance. While crossmodal effects of odor valence on perceived attractiveness of facial features have been demonstrated experimentally, it is unknown whether they represent a phenomenon specific to affective processing. In this experiment, we presented odors in the context of a face battery with systematic feature manipulations during a speeded response task. Modulatory effects of linear increases of odor valence were investigated by juxtaposing subsequent memory-based ratings tasks--one predominantly affective (attractiveness) and a second, cognitive (age). The linear modulation pattern observed for attractiveness was consistent with additive effects of face and odor appraisal. Effects of odor valence on age perception were not linearly modulated and may be the result of cognitive interference. Affective and cognitive processing of faces thus appear to differ in their susceptibility to modulation by odors, likely as a result of privileged access of olfactory stimuli to affective brain networks. These results are critically discussed with respect to potential biases introduced by the preceding speeded response task.

  16. Special needs hurricane shelters and the ageing population: development of a methodology and a case study application.

    Science.gov (United States)

    Horner, Mark W; Ozguven, Eren Erman; Marcelin, Jean Michael; Kocatepe, Ayberk

    2018-01-01

    Recent experience of hurricanes, particularly in the southeast United States, has heightened awareness of the multifaceted nature of and the challenges to effective disaster relief planning. One key element of this planning is providing adequate shelter at secure locations for people who evacuate. Some of these individuals will have 'special needs', yet there is little research on the relationship with shelter space. This study designed a geographic information systems-based network optimisation methodology for the siting of special needs hurricane relief shelters, with a focus on the transportation component. It sought to find new locations for shelters that maximise accessibility by vulnerable populations, given capacity constraints, concentrating on the ageing population. The framework was implemented in a medium-sized metropolitan statistical area in the state of Florida where data suggest a possible deficit in special needs shelter space. The study analysed options for increasing special needs shelter capacity, while considering potential uncertainties in transportation network availability. © 2018 The Author(s). Disasters © Overseas Development Institute, 2018.

  17. Associations of clinical features and prognosis with age at disease onset in patients with systemic lupus erythematosus.

    Science.gov (United States)

    Feng, X; Zou, Y; Pan, W; Wang, X; Wu, M; Zhang, M; Tao, J; Zhang, Y; Tan, K; Li, J; Chen, Z; Ding, X; Qian, X; Da, Z; Wang, M; Sun, L

    2014-03-01

    The objective of this study is to evaluate the association of clinical features and prognosis with age at disease onset in patients with systemic lupus erythematosus (SLE) in a large, multicenter Chinese cohort. Medical records of 1898 SLE inpatients from 15 hospitals were reviewed and classified into three groups according to their ages at disease presentation. Categorical data were analyzed by chi-square test and potentially associated factors were tested by multinomial logistic regression. Among the patients studied, 259 (13.6%) were juvenile onset (≤18 years), 1444 (76.1%) were early onset (>18 and ≤45 years) and 195 (10.3%) were late onset (>45 years). Whenever manifestations occurred, most patients (>80%) were diagnosed within two years. Juvenile-onset patients were more likely to be untreated before admission (p lupus. Interestingly, our data showed that more patients with late-onset disease had a SLEDAI score change of >7 at discharge. In conclusion, age at onset has an impact on SLE disease status, and infection is the main cause of death in those with late-onset lupus. Considering that the late-onset patients had simultaneously easily controllable diseases and high incidence of comorbidities, a different treatment strategy from younger patients should be considered.

  18. Age-related differences in features associated with polycystic ovary syndrome in normogonadotrophic oligo-amenorrhoeic infertile women of reproductive years

    NARCIS (Netherlands)

    H. Bili; B. Imani (Babak); M.J.C. Eijkemans (René); B.C.J.M. Fauser (Bart); J.S.E. Laven (Joop)

    2001-01-01

    textabstractOBJECTIVE: To assess the effect of age on clinical, endocrine and sonographic features associated with polycystic ovary syndrome (PCOS) in normogonadotrophic anovulatory infertile women of reproductive years. DESIGN: Cross-sectional study. METHODS: Four hundred and

  19. Features of Formation of Personality Traits of School-Age Children in the Use of Measures for Psychohygienic Correction

    Directory of Open Access Journals (Sweden)

    O.P. Mostova

    2013-09-01

    Full Text Available The article describes the features of the formation of personality traits of school-age chidren in the use of diagnostic and preventive programs psychohygienic correction for disorders of psychophysiological and psychological adaptation and changes in the health of 14–17-year-old students. To assess personality characteristics of students we used personality questionnaires of Eysenck, Spielberg and Phillips. The results determine the positive impact of measures for psychohygienic correction on the state of criterion parameters of anxious-neurotic personality traits of students of school age. Implementation of the developed program provide the appearance of the positive changes in the structure of indicators that display characteristics of neuroticism (p < 0.05, situational (p < 0.001 and personal (p < 0.01 anxiety both among girls and boys, and in the structure of indicators of school anxiety, determining the existence of problems in relationships with teachers (p < 0.05 among girls. Changes recorded during the analysis of the other components of school anxiety, i.e. personality traits of anxiety, adverse changes in the structure of which are directly related to the impact of such stressor as a modern school, had to be recognized as less significant, but in this case revealed changes should be interpreted as favorable.

  20. Age-Related Features of Reactive Catecholamine Shifts in the Spinal Cord in Acute Somatic Pain: Experimental Study

    Directory of Open Access Journals (Sweden)

    V. G. Ovsyannikov

    2007-01-01

    Full Text Available Objective: to study the age-related features of an adrenergic response of the central nervous system to acute somatic pain (ASP.Subjects and methods: The spinal cord (SC levels of adrenaline (A, noradrenaline (NA, and dopamine (DA were studied in albino male rats of five age groups: 1 neonatal (2—4-day rats; 2 17—18-day rats that began to see; 3 monthly rats; 4 sexually mature (3—4 month ones; and 5 old ones aged over 2 years. ASP was reproduced by electrodermal stimulation of the rat tail; the levels of catecholamines (CA were measured by spectrofluorimetric microassay.Results. During postnatal ontogenesis, the rats were found to have a phase pattern of physiological changes in the spinal concentrations of CA: a decrease in their high neonatal levels (due to DA by the time the animals began to see; their progressive increase by prepuberty (due to NA and in sexually maturity (due to A and DA, and a reduction in all CA fractions in old rats. ASP was attended by a rise in the SC concentration of CA in the neonatal animals and by clearly-cut reactive shifts in all fractions in the old ones. With A and DA increases, the SC concentrations of NA halved in the rats that began to see and had ASP; the amount of CA remained unchanged as compared with the controls. In prepubertal and sexually mature male rats, there was a reduction in the spinal CA pool, but due to different components: to A and NA in 35-day rats and to A and DA in 3-month ones.Conclusion. Age-related changes in the pattern of a spinal CA response in rats with ASP show a ontogenetic trend in the development of adrenal responsiveness from the immature generalized forms of an early postnatal period to the definitive differentiated economic reactions of the hypo-to-normergic type and then to the hyperergic destructive reactions of old age

  1. Comparison of the clinical features and outcomes in two age-groups of elderly patients with atrial fibrillation

    Directory of Open Access Journals (Sweden)

    Shao XH

    2014-08-01

    Full Text Available Xing-Hui Shao,1 Yan-Min Yang,1 Jun Zhu,1 Han Zhang,1 Yao Liu,1 Xin Gao,1 Li-Tian Yu,1 Li-Sheng Liu,1 Li Zhao,2 Peng-Fei Yu,3 Hua Zhang,4 Qing He,5 Xiao-Dan Gu6 1Emergency and Intensive Care Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 2Department of Emergency, Fu Xing Hospital, Capital Medical University, Beijing, 3Department of Cardiology, Pingdu People’s Hospital, Pingdu, 4Department of Emergency, Qingdao Municipal Hospital, Qingdao, 5Department of Emergency, West China Hospital, Sichuan University, Chengdu, 6Department of Emergency, Sixth People’s Hospital of Chengdu, Chengdu, People’s Republic of China Background: Atrial fibrillation (AF disproportionately affects older adults. However, direct comparison of clinical features, medical therapy, and outcomes in AF patients aged 65–74 and ≥75 years is rare. The objective of the present study was to evaluate the differences in clinical characteristics and prognosis in these two age-groups of geriatric patients with AF.Materials and methods: A total of 1,336 individuals aged ≥65 years from a Chinese AF registry were assessed in the present study: 570 were in the 65- to 74-year group, and 766 were in the ≥75-year group. Multivariable Cox hazards regression was performed to analyze the major adverse cardiac events (MACEs between groups.Results: In our population, the older group were more likely to have coronary artery disease, hypertension, previous stroke, cognitive disorder, or chronic obstructive pulmonary disease, and the 65- to 74-year group were more likely to have valvular heart disease, left ventricular systolic dysfunction, or sleep apnea. The older patients had 1.2-fold higher mean CHADS2 (congestive heart failure, hypertension, age ≥75 years, diabetes, stroke scores, but less ­probability of being prescribed drugs. Compared with those aged 65–74 years, the older group had a higher risk of death (hazard ratio 2

  2. A Methodology for Modeling Nuclear Power Plant Passive Component Aging in Probabilistic Risk Assessment under the Impact of Operating Conditions, Surveillance and Maintenance Activities

    Science.gov (United States)

    Guler Yigitoglu, Askin

    In the context of long operation of nuclear power plants (NPPs) (i.e., 60-80 years, and beyond), investigation of the aging of passive systems, structures and components (SSCs) is important to assess safety margins and to decide on reactor life extension as indicated within the U.S. Department of Energy (DOE) Light Water Reactor Sustainability (LWRS) Program. In the traditional probabilistic risk assessment (PRA) methodology, evaluating the potential significance of aging of passive SSCs on plant risk is challenging. Although passive SSC failure rates can be added as initiating event frequencies or basic event failure rates in the traditional event-tree/fault-tree methodology, these failure rates are generally based on generic plant failure data which means that the true state of a specific plant is not reflected in a realistic manner on aging effects. Dynamic PRA methodologies have gained attention recently due to their capability to account for the plant state and thus address the difficulties in the traditional PRA modeling of aging effects of passive components using physics-based models (and also in the modeling of digital instrumentation and control systems). Physics-based models can capture the impact of complex aging processes (e.g., fatigue, stress corrosion cracking, flow-accelerated corrosion, etc.) on SSCs and can be utilized to estimate passive SSC failure rates using realistic NPP data from reactor simulation, as well as considering effects of surveillance and maintenance activities. The objectives of this dissertation are twofold: The development of a methodology for the incorporation of aging modeling of passive SSC into a reactor simulation environment to provide a framework for evaluation of their risk contribution in both the dynamic and traditional PRA; and the demonstration of the methodology through its application to pressurizer surge line pipe weld and steam generator tubes in commercial nuclear power plants. In the proposed methodology, a

  3. Methodology of aging management in structures, systems and components of a nuclear power plant and its application to a pilot program in Laguna Verde

    International Nuclear Information System (INIS)

    Jarvio C, G.; Fernandez S, G.

    2009-10-01

    From its origin the nuclear power plants confront the effects of time and of environment, giving as result the aging of its structures, systems and components. In this document the general process is described for the establishment of Aging Management Program developed by IAEA. Following the program methodology is guaranteed that a nuclear power plant manages the aging effects appropriately and to make decisions for its solution, assuring the characteristic functions of structures, systems and components of same nuclear power plant. On the other hand, the implantation of an aging management program constitutes the base for development of a licence renovation program, like it can be the specific case of the Central Laguna Verde Units 1 and 2. (Author)

  4. Metodologicheskie osobennosti upravlenija stoimost'ju kompanii, osushhestvljajushhej «zelenye» innovacii [The methodological features of managing the value of companies introducing "green" innovations

    Directory of Open Access Journals (Sweden)

    Kharin Alexander

    2012-01-01

    Full Text Available Although it is a common assumption that innovations are one of the most important factors of economic development, there is a need to review some provisions of innovation methodology so that new fundamental values are taken into account more fully. Most recent business models are based on the depletion of natural environment, whose potential has been almost exhausted. It is necessary to introduce new ideas that are of use for society and create values for companies. One way of achieving this goal is “green” (environmental innovations. The next decade is expected to see a rapid growth in environmental innovations. Their organization and management will require modern — and adequate to the objectives set —technologies. One of those is the quest for value methodology. To date, the quest for value methodology has given rise to several conceptual approaches, which can be used to evaluate the effectiveness of environmental innovations. This article discusses the advantages and disadvantages of major approaches. The author comes to a conclusion that that the modern theory and practice of corporate finance still lacks a generally accepted approach to assessing the value of companies that explicitly takes into account the impact of environmental factors on the cost. The article outlines the basic theoretical frameworks for the formation of such approach.

  5. Psychohygienic estimation of features of the formation of properties of character of pupils aged 14-17 years in the dynamics of learning at modern schools

    Directory of Open Access Journals (Sweden)

    Serheta I.V.

    2013-10-01

    Full Text Available The aim of scientific work was psychohygienic estimation of features of the formation of properties of character of pupils aged 14-17 years old in the dynamics of learning at modern schools. The studies were conducted on the basis of secondary schools in the city of Vinnitsya. Evaluation of the formation of properties of character was carried out using a personality questionnaire Mini-mult. It was determined that in the structure of personal profile of properties of character in girls aged 14-17 years during the period of study at school predominance of characterologic features according to schizoid scales (Se and pscychasthenia (Pt (block 1 of characterologic features, hypochondria (Hs and depression (D (block 2 of characterologic features, hypomania (Ma and hysteria (Hy (block 3 of characterologic features is registered. In the structure of personal profile of properties of character of boys of 14-17 years during the period of study at school predominance of characterologic properties according to psychasthenia (Pt and schizoid (Se (block 1 of characterologic features, hypochondria (Hs and depression (D (block 2, paranoid (Pa and hypomania (Ma (block 3 is registered. The results suggest the need to consider the properties of character of schoolchildren in development of health-saving technologies, sanitation measures and psychohygienic effect on the pupils’ organism.

  6. Diffusion tensor trace mapping in normal adult brain using single-shot EPI technique: A methodological study of the aging brain

    International Nuclear Information System (INIS)

    Chen, Z.G.; Hindmarsh, T.; Li, T.Q.

    2001-01-01

    Purpose: To quantify age-related changes of the average diffusion coefficient value in normal adult brain using orientation-independent diffusion tensor trace mapping and to address the methodological influences on diffusion quantification. Material and Methods: Fifty-four normal subjects (aged 20-79 years) were studied on a 1.5-T whole-body MR medical unit using a diffusion-weighted single-shot echo-planar imaging technique. Orientation-independent diffusion tensor trace maps were constructed for each subject using diffusion-weighted MR measurements in four different directions using a tetrahedral gradient combination pattern. The global average (including cerebral spinal fluid) and the tissue average of diffusion coefficients in adult brains were determined by analyzing the diffusion coefficient distribution histogram for the entire brain. Methodological influences on the measured diffusion coefficient were also investigated by comparing the results obtained using different experimental settings. Results: Both global and tissue averages of the diffusion coefficient are significantly correlated with age (p<0.03). The global average of the diffusion coefficient increases 3% per decade after the age of 40, whereas the increase in the tissue average of diffusion coefficient is about 1% per decade. Experimental settings for self-diffusion measurements, such as data acquisition methods and number of b-values, can slightly influence the statistical distribution histogram of the diffusion tensor trace and its average value. Conclusion: Increased average diffusion coefficient in adult brains with aging are consistent with findings regarding structural changes in the brain that have been associated with aging. The study also demonstrates that it is desirable to use the same experimental parameters for diffusion coefficient quantification when comparing between different subjects and groups of interest

  7. The influence of age and gender on motor and non-motor features of early Parkinson's disease: initial findings from the Oxford Parkinson Disease Center (OPDC) discovery cohort.

    Science.gov (United States)

    Szewczyk-Krolikowski, Konrad; Tomlinson, Paul; Nithi, Kannan; Wade-Martins, Richard; Talbot, Kevin; Ben-Shlomo, Yoav; Hu, Michele T M

    2014-01-01

    Identifying factors influencing phenotypic heterogeneity in Parkinson's Disease is crucial for understanding variability in disease severity and progression. Age and gender are two most basic epidemiological characteristics, yet their effect on expression of PD symptoms is not fully defined. We aimed to delineate effects of age and gender on the phenotype in an incident cohort of PD patients and healthy controls from the Oxford Parkinson Disease Centre (OPDC). Clinical features, including demographic and medical characteristics and non-motor and motor symptoms, were analyzed in a group of PD patients within 3 years of diagnosis and a group of healthy controls from the OPDC cohort. Disease features were stratified according to age and compared between genders, controlling for effects of common covariates. 490 PD patients and 176 healthy controls were analyzed. Stratification by age showed increased disease severity with age on motor scales. Some non-motor features showed similar trend, including cognition and autonomic features. Comparison across genders highlighted a pattern of increased severity and greater symptom symmetricality in the face, neck and arms in men with women having more postural problems. Amongst the non-motor symptoms, men had more cognitive impairment, greater rate of REM behavior disorder (RBD), more orthostatic hypotension and sexual dysfunction. Age in PD is a strong factor contributing to disease severity even after controlling for the effect of disease duration. Gender-related motor phenotype can be defined by a vertical split into more symmetrical upper-body disease in men and disease dominated by postural symptoms in women. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. Recognizing the Face of Johnny, Suzy, and Me: Insensitivity to the Spacing Among Features at 4 Years of Age

    Science.gov (United States)

    Mondloch, Catherine J.; Leis, Anishka; Maurer, Daphne

    2006-01-01

    Four-year-olds were tested for their ability to use differences in the spacing among features to recognize familiar faces. They were given a storybook depicting multiple views of 2 children. They returned to the laboratory 2 weeks later and used a "magic wand" to play a computer game that tested their ability to recognize the familiarized faces…

  9. Predicting borderline personality disorder features from personality traits, identity orientation, and attachment styles in Italian nonclinical adults: issues of consistency across age ranges.

    Science.gov (United States)

    Fossati, Andrea; Borroni, Serena; Feeney, Judith; Maffei, Cesare

    2012-04-01

    The aims of this study were to assess whether Borderline Personality Disorder (BPD) features could be predicted by Big Five traits, impulsivity, identity orientation, and adult attachment patterns in a sample of 1,192 adult nonclinical participants, and to evaluate the consistency of these regression models across four age groups (49 years, and >50 years, respectively). In the full sample, measures of neuroticism (N), impulsivity, and anxious insecure attachment were substantial predictors of BPD features (adjusted R(2) = .38, p personality traits and disturbed attachment patterns.

  10. Visual recognition of age class and preference for infantile features: implications for species-specific vs universal cognitive traits in primates.

    Directory of Open Access Journals (Sweden)

    Anna Sato

    Full Text Available Despite not knowing the exact age of individuals, humans can estimate their rough age using age-related physical features. Nonhuman primates show some age-related physical features; however, the cognitive traits underlying their recognition of age class have not been revealed. Here, we tested the ability of two species of Old World monkey, Japanese macaques (JM and Campbell's monkeys (CM, to spontaneously discriminate age classes using visual paired comparison (VPC tasks based on the two distinct categories of infant and adult images. First, VPCs were conducted in JM subjects using conspecific JM stimuli. When analyzing the side of the first look, JM subjects significantly looked more often at novel images. Based on analyses of total looking durations, JM subjects looked at a novel infant image longer than they looked at a familiar adult image, suggesting the ability to spontaneously discriminate between the two age classes and a preference for infant over adult images. Next, VPCs were tested in CM subjects using heterospecific JM stimuli. CM subjects showed no difference in the side of their first look, but looked at infant JM images longer than they looked at adult images; the fact that CMs were totally naïve to JMs suggested that the attractiveness of infant images transcends species differences. This is the first report of visual age class recognition and a preference for infant over adult images in nonhuman primates. Our results suggest not only species-specific processing for age class recognition but also the evolutionary origins of the instinctive human perception of baby cuteness schema, proposed by the ethologist Konrad Lorenz.

  11. A level set methodology for predicting the effect of mask wear on surface evolution of features in abrasive jet micro-machining

    International Nuclear Information System (INIS)

    Burzynski, T; Papini, M

    2012-01-01

    A previous implementation of narrow-band level set methodology developed by the authors was extended to allow for the modelling of mask erosive wear in abrasive jet micro-machining (AJM). The model permits the prediction of the surface evolution of both the mask and the target simultaneously, by representing them as a hybrid and continuous mask–target surface. The model also accounts for the change in abrasive mass flux incident to both the target surface and, for the first time, the eroding mask edge, that is brought about by the presence of the mask edge itself. The predictions of the channel surface and eroded mask profiles were compared with measurements on channels machined in both glass and poly-methyl-methacrylate (PMMA) targets at both normal and oblique incidence, using tempered steel and elastomeric masks. A much better agreement between the predicted and measured profiles was found when mask wear was taken into account. Mask wear generally resulted in wider and deeper glass target profiles and wider PMMA target profiles, respectively, when compared to cases where no mask wear was present. This work has important implications for the AJM of complex MEMS and microfluidic devices that require longer machining times. (paper)

  12. The Relative Importance of Family History, Gender, Mode of Onset, and Age at Onsetin Predicting Clinical Features of First-Episode Psychotic Disorders.

    Science.gov (United States)

    Compton, Michael T; Berez, Chantal; Walker, Elaine F

    Family history of psychosis, gender, mode of onset, and age at onset are considered prognostic factors important to clinicians evaluating first-episode psychosis; yet, clinicians have little guidance as to how these four factors differentially predict early-course substance abuse, symptomatology, and functioning. We conducted a "head-to-head comparison" of these four factors regarding their associations with key clinical features at initial hospitalization. We also assessed potential interactions between gender and family history with regard to age at onset of psychosis and symptom severity. Consecutively admitted first-episode patients (n=334) were evaluated in two studies that rigorously assessed a number of early-course variables. Associations among variables of interest were examined using Pearson correlations, χ 2 tests, Student's t-tests, and 2×2 factorial analyses of variance. Substance (nicotine, alcohol, and cannabis) abuse and positive symptom severity were predicted only by male gender. Negative symptom severity and global functioning impairments were predicted by earlier age at onset of psychosis. General psychopathology symptom severity was predicted by both mode of onset and age at onset. Interaction effects were not observed with regard to gender and family history in predicting age at onset or symptom severity. The four prognostic features have differential associations with substance abuse, domains of symptom severity, and global functioning. Gender and age at onset of psychosis appear to be more predictive of clinical features at the time of initial evaluation (and thus presumably longer term outcomes) than the presence of a family history of psychosis and a more gradual mode of onset.

  13. Collagen type I from bovine bone. Effect of animal age, bone anatomy and drying methodology on extraction yield, self-assembly, thermal behaviour and electrokinetic potential.

    Science.gov (United States)

    Ferraro, Vincenza; Gaillard-Martinie, Brigitte; Sayd, Thierry; Chambon, Christophe; Anton, Marc; Santé-Lhoutellier, Véronique

    2017-04-01

    Natural collagen is easily available from animal tissues such as bones. Main limitations reported in the use of natural collagen are heterogeneity and loss of integrity during recovery. However, its natural complexity, functionality and bioactivity still remain to be achieved through synthetic and recombinant ways. Variability of physicochemical properties of collagen extracted from bovine bone by acetic acid was then investigated taking into account endogenous and exogenous factors. Endogenous: bovine's bones age (4 and 7 years) and anatomy (femur and tibia); exogenous: thermal treatments (spray-drying and lyophilisation). Scanning electron microscopy, spectroscopy (EDS, FTIR, UV/Vis and CD), differential scanning calorimetry (DSC), centesimal composition, mass spectrometry, amino acids and zeta-potential analysis were used for the purpose. Age correlated negatively with yield of recovery and positively with minerals and proteoglycans content. Comparing the anatomy, higher yields were found for tibias, and higher stability of tibias collagen in solution was noticed. Whatever the age and the anatomy, collagens were able to renature and to self-assemble into tri-dimensional structures. Nonetheless thermal stability and kinetics of renaturation were different. Variability of natural collagen with bone age and anatomy, and drying methodology, may be a crucial advantage to conceive tailor-made applications in either the biological or technical sector. Copyright © 2016 Elsevier B.V. All rights reserved.

  14. The ties to unbind: Age-related differences in feature (unbinding in working memory for emotional faces

    Directory of Open Access Journals (Sweden)

    Didem ePehlivanoglu

    2014-04-01

    Full Text Available In the present study, we investigated age-related differences in the processing of emotional stimuli. Specifically, we were interested in whether older adults would show deficits in unbinding emotional expression (i.e., either no emotion, happiness, anger, or disgust from bound stimuli (i.e., photographs of faces expressing these emotions, as a hyperbinding account of age-related differences in working memory would predict. Younger and older adults completed different N-Back tasks (side-by-side 0-Back, 1-Back, 2-Back under three conditions: match/mismatch judgments based on either the identity of the face (identity condition, the face’s emotional expression (expression condition, or both identity and expression of the face (binding condition. Both age groups performed more slowly and with lower accuracy in the expression condition than in the binding condition, indicating the presence of an unbinding process. This unbinding effect was more pronounced in older adults than in younger adults, but only in the 2-Back task. Thus, older adults seemed to have a specific deficit in unbinding in working memory, over and beyond age-related differences observed in perceptual processing (0-Back and attention/short-term memory (1-Back. Additionally, no age-related differences were found in accuracy in the 0-Back task, but such differences emerged in the 1-Back task, and were further magnified in the 2-Back task, indicating independent age-related differences in attention/short-term memory and working memory. Pupil dilation data confirmed that the attention/short-term memory version of the task (1-Back is more effortful in older adults than younger adults.

  15. The association between peer, parental influence and tobacco product features and earlier age of onset of regular smoking among adults in 27 European countries.

    Science.gov (United States)

    Filippidis, Filippos T; Agaku, Israel T; Vardavas, Constantine I

    2015-10-01

    Factors that influence smoking initiation and age of smoking onset are important considerations in tobacco control. We evaluated European Union (EU)-wide differences in the age of onset of regular smoking, and the potential role of peer, parental and tobacco product design features on the earlier onset of regular smoking among adults influenced their decision to start smoking, including peer influence, parental influence and features of tobacco products. Multi-variable logistic regression, adjusted for age; geographic region; education; difficulty to pay bills; and gender, was used to assess the role of the various pro-tobacco influences on early onset of regular smoking (i.e. influenced by peers (OR = 1.70; 95%CI 1.30-2.20) or parents (OR = 1.60; 95%CI 1.21-2.12) were more likely to have started smoking regularly <18 years old. No significant association between design and marketing features of tobacco products and an early initiation of regular smoking was observed (OR = 1.04; 95%CI 0.83-1.31). We identified major differences in smoking initiation patterns among EU countries, which may warrant different approaches in the prevention of tobacco use. © The Author 2015. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.

  16. Demographic features and premorbid personality disorder traits in relation to age of onset and sex in paranoid schizophrenia.

    Science.gov (United States)

    Skokou, Maria; Gourzis, Philippos

    2014-03-30

    Personality disorders in the premorbid period of schizophrenia and particularly in relation to age of onset and sex, seem to be a rather under-researched area. In the present study, 88 patients with paranoid schizophrenia were examined, regarding demographic characteristics and premorbid personality disorder traits, in order to investigate for differences in the premorbid period of the disease, in relation to age of onset and sex. Age cutoff points were set at personality disorder traits were retrospectively assessed by using the Structured Clinical Interview for DSM-IV-Patient Edition for Axis II disorders (SCID-II). Comparisons were performed by applying the two-tailed Wilcoxon rank-sum and the χ(2) statistical tests. Young onset patients were characterized by significantly higher proportion of urban birth, single status, more avoidant premorbid personality disorder traits, and less passive-aggressive premorbid personality disorder traits, than late onset counterparts. Differences were more prominently shown in men. Earlier age of onset seems to be associated to increased social inhibition and worse psychosocial adaptation in the premorbid period of paranoid schizophrenia. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  17. Cfh genotype interacts with dietary glycemic index to modulate age-related macular degeneration-like features in mice

    Science.gov (United States)

    Age-related macular degeneration (AMD) is a leading cause of visual impairment worldwide. Genetics and diet contribute to the relative risk for developing AMD, but their interactions are poorly understood. Genetic variations in Complement Factor H (CFH), and dietary glycemic index (GI) are major ris...

  18. Fanconi Anemia: A DNA repair disorder characterized by accelerated decline of the hematopoietic stem cell compartment and other features of aging.

    Science.gov (United States)

    Brosh, Robert M; Bellani, Marina; Liu, Yie; Seidman, Michael M

    2017-01-01

    Fanconi Anemia (FA) is a rare autosomal genetic disorder characterized by progressive bone marrow failure (BMF), endocrine dysfunction, cancer, and other clinical features commonly associated with normal aging. The anemia stems directly from an accelerated decline of the hematopoietic stem cell compartment. Although FA is a complex heterogeneous disease linked to mutations in 19 currently identified genes, there has been much progress in understanding the molecular pathology involved. FA is broadly considered a DNA repair disorder and the FA gene products, together with other DNA repair factors, have been implicated in interstrand cross-link (ICL) repair. However, in addition to the defective DNA damage response, altered epigenetic regulation, and telomere defects, FA is also marked by elevated levels of inflammatory mediators in circulation, a hallmark of faster decline in not only other hereditary aging disorders but also normal aging. In this review, we offer a perspective of FA as a monogenic accelerated aging disorder, citing the latest evidence for its multi-factorial deficiencies underlying its unique clinical and cellular features. Published by Elsevier B.V.

  19. Cross-sectional analysis of the effects of age on the hormonal, metabolic, and ultrasonographic features and the prevalence of the different phenotypes of polycystic ovary syndrome.

    Science.gov (United States)

    Panidis, Dimitrios; Tziomalos, Konstantinos; Macut, Djuro; Delkos, Dimitrios; Betsas, George; Misichronis, Georgios; Katsikis, Ilias

    2012-02-01

    To assess the effects of age on the hormonal, metabolic, and ultrasonographic features of polycystic ovary syndrome (PCOS). Observational study. University department of obstetrics and gynecology. Patients with PCOS (n = 1,212) and healthy women (n = 254). None. Differences in the hormonal, metabolic, and ultrasonographic features of PCOS between age groups. A progressive decline in circulating androgens was observed with advancing age. Patients 21-30 years old had lower plasma glucose and insulin levels, lower area under the oral glucose tolerance test curve and lower homeostasis model assessment of insulin resistance index, and higher glucose/insulin and quantitative insulin sensitivity check index than patients 31-39 years old. The prevalence of PCOS phenotypes changed with age. More specifically, the distribution of the phenotypes did not differ substantially between patients ≤ 20 years old and patients 21-30 years old. However, a decline in the prevalence of phenotype 1 (characterized by anovulation, hyperandrogenemia, and polycystic ovaries) and an increase in the prevalence of phenotype 4 (characterized by anovulation and polycystic ovaries without hyperandrogenemia) were observed in patients 31-39 years old. In women with PCOS, hyperandrogenemia appears to diminish during reproductive life whereas insulin resistance worsens. Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  20. Stress responsiveness of the hypothalamic-pituitary-adrenal axis: age-related features of the vasopressinergic regulation

    Directory of Open Access Journals (Sweden)

    Nadezhda Dmitrievna Goncharova

    2013-03-01

    Full Text Available The hypothalamic-pituitary-adrenal (HPA axis plays a key role in adaptation to environmental stresses. Parvicellular neurons of the hypothalamic paraventricular nucleus secrete corticotrophin releasing hormone (CRH and arginine vasopressin (AVP into pituitary portal system; CRH and AVP stimulate ACTH release through specific G protein-coupled membrane receptors on pituitary corticotrophs, CRH1 for CRH and V1b for AVP; the adrenal gland cortex secretes glucocorticoids in response ACTH. The glucocorticoids activate specific receptors in brain and peripheral tissues thereby triggering the necessary metabolic, immune, neuromodulatory and behavioral changes to resist stress. While importance of CRH, as a key hypothalamic factor of HPA axis regulation in basal and stress conditions in most species, is generally recognized, role of AVP remains to be clarified. This review focuses on the role of AVP in the regulation of stress responsiveness of the HPA axis with emphasis on the effects of aging on vasopressinergic regulation of HPA axis stress responsiveness. Under most of the known stressors, AVP is necessary for acute ACTH secretion but in a context-specific manner. The current data on the AVP role in regulation of HPA responsiveness to chronic stress in adulthood are rather contradictory. The importance of the vasopressinergic regulation of the HPA stress responsiveness is greatest during fetal development, in neonatal period, and in the lactating adult. Aging associated with increased variability in several parameters of HPA function including basal state, responsiveness to stressors, and special testing. Reports on the possible role of the AVP/V1b receptor system in the increase of HPA axis hyperactivity with aging are contradictory and requires further research. Many contradictory results may be due to age and species differences in the HPA function of rodents and primates.

  1. FEATURES OF MEMORY IN CHILDREN OF PRESCHOOL AGE WITH CONSEQUENCES OF PERINATAL LESIONS OF THE CENTRAL NERVOUS SYSTEM

    Directory of Open Access Journals (Sweden)

    T. S. Krivonogova

    2014-01-01

    Full Text Available The ability of memory was investigated in 524 children, aged 4 to 7; with remote consequences of perinatal damage of the central nervous system (CNS. A weak memory ability was detected in 42% of children with dysfunctions of the general and fine motility and in 59% of children with impaired speech. Severe gestosis, anemia in pregnancy (stage II and a delayed intrauterine fetal development were found to have a negative influence on memory shaping process.

  2. VOLUNTARY SURGICAL CONTRACEPTION OF WOMEN OF LATE REPRODUCTIVE AGE SUFFERING FROM PELVIC ORGAN PROLAPSE – FEATURES AND BENEFITS

    OpenAIRE

    Nigina Nasimova

    2015-01-01

    In recent years there has been a noticeable "rejuvenation" of pelvic organ prolapse. Inconsistency of the pelvic floor muscles, including the omission of sexual organs, is extremely common pathology, observed almost a third of women of reproductive age. The search for effective, convenient methods of contraception for this category of patients is an important problem of modern gynecology.We proposed a method of transvaginal voluntary surgical contraception, produced in conjunction with surgic...

  3. Increased levels of circulating CD34+ cells in neovascular age-related macular degeneration: relation with clinical and OCT features.

    Science.gov (United States)

    Kara, Caner; Özdal, Pınar Ç; Beyazyıldız, Emrullah; Özcan, Nurgül E; Teke, Mehmet Y; Vural, Gülden; Öztürk, Faruk

    2018-01-01

    To investigate the levels of circulating CD34+ stem cells in patients with neovascular type age-related macular degeneration (AMD) and its relation with clinical and optical coherence tomography (OCT) findings. The study consisted of 55 patients: 28 patients (18 male and 10 female) with neovascular type AMD as a study group and 27 patients (12 male and 15 female) scheduled for cataract surgery as a control group. The level of CD34+ stem cells was measured by flow cytometry. Demographic and clinical data were recorded. The mean ages of patients in the study and control groups were 71 ± 8 and 68 ± 6 years, respectively. There was no statistically significant difference in terms of age, sex, or systemic disease association between study and control groups. However, smoking status was significantly higher in the study group (67.9% vs 37.0%; p = 0.02). Stem cell levels were significantly higher in the study group (1.5 ± 0.9 vs 0.5 ± 0.3; p<0.001), but there was no relation between stem cell levels and clinical and OCT findings. Increased circulating CD34+ stem cell levels were observed in patients with choroidal neovascular membrane associated with AMD, but no significant relation was found between cell levels and clinical and OCT findings.

  4. Oestrogen receptors in breast tumours: associations with age, menopausal status and epidemiological and clinical features in 735 patients.

    Science.gov (United States)

    Elwood, J M; Godolphin, W

    1980-11-01

    Comparisons between oestrogen-receptor (RE)-positive or negative patients were made on a continuous series of 735 patients with primary breast tumours seen at the major treatment centre in British Columbia between 1975 and 1978. RE positivity was commoner in older patients, and was not associated with menopausal status independently of age. The concentration of receptor protein also increased with increasing age, but was not affected by menopausal status. Neither RE status nor quantity was associated with any of the epidemiological risk factors studied, which included parity, age at first birth, weight, family history and exposure to oestrogenic drugs and oral contraceptives. Patients with RE- tumours were more likely to present with symptoms other than a breast lump, pain or nipple inversion, and had less-differentiated tumours; they did not differ from RE+ patients in terms of stage, size of tumour, or interval from first symptom. These findings are discussed in terms of the biological origin and determinants of oestrogen receptors.

  5. ‘Place’ as conceptual centre: a methodological focus on the bodily relations, movements and expressions of children up to three years of age in kindergarten

    Directory of Open Access Journals (Sweden)

    Karin Hognestad

    2012-12-01

    Full Text Available The purpose of this article is to show how attention on ‘place’ can be productive in methodology concerning the bodily relations, movements and expressions of children up to three years of age who are enrolled in kindergarten. While research that has adopted a hermeneutic and phenomenological approach has contributed to important knowledge concerning young children, we propose re-thinking methodology that takes children’s bodily relations, movements and expressions into concern. Using ‘place’ as a lens, we show how power relations are interrupted and allow for alternative ways for the researcher to relate to data. Inspired by Somerville (2010, elements of place are situated at the centre of the research analysis. The three key elements of place that are put to work are as follows: our relationship to place is constituted in stories and other representations; place learning is local and embodied; and place is a contact zone for cultural contact. The paper is part of a research project which explores how place can be more explicit in educational practices to strengthen kindergarten as a learning arena. We seek to explore how place relations work and what they have the possibility of producing in the analyzing process.

  6. Features of physiological responses on organism of football players aged 10-12 years in exercise using different training methods

    Directory of Open Access Journals (Sweden)

    A. B. Abdula

    2014-02-01

    Full Text Available Purpose : To evaluate the effect of various special exercises football players’ organism in different modes. Material : The study involved 24 young players aged 10-12 years. Results : There is a large range of load parameters for elite athletes, which necessitates evaluation exercise intensity football for young players. Found that depending on the method chosen football special exercises have different effects on the body force young players. Conclusions : It was found that by using the method of competitive gaming and heart rate and energy increases with increasing number of players. The analysis shows the existence of significant differences in terms of heart rate for game and interval method.

  7. Peculiar Features of Thermal Aging and Degradation of Rapidly Quenched Stainless Steels under High-Temperature Exposures

    Science.gov (United States)

    Shulga, A. V.

    2017-12-01

    This article presents the results of comparative studies of mechanical properties and microstructure of nuclear fuel tubes and semifinished stainless steel items fabricated by consolidation of rapidly quenched powders and by conventional technology after high-temperature exposures at 600 and 700°C. Tensile tests of nuclear fuel tube ring specimens of stainless austenitic steel of grade AISI 316 and ferritic-martensitic steel are performed at room temperature. The microstructure and distribution of carbon and boron are analyzed by metallography and autoradiography in nuclear fuel tubes and semifinished items. Rapidly quenched powders of the considered steels are obtained by the plasma rotating electrode process. Positive influence of consolidation of rapidly quenched powders on mechanical properties after high-temperature aging is confirmed. The correlation between homogeneous distribution of carbon and boron and mechanical properties of the considered steel is determined. The effects of thermal aging and degradation of the considered steels are determined at 600°C and 700°C, respectively.

  8. Risk and safety perception on urban and rural roads: Effects of environmental features, driver age and risk sensitivity.

    Science.gov (United States)

    Cox, Jolene A; Beanland, Vanessa; Filtness, Ashleigh J

    2017-10-03

    The ability to detect changing visual information is a vital component of safe driving. In addition to detecting changing visual information, drivers must also interpret its relevance to safety. Environmental changes considered to have high safety relevance will likely demand greater attention and more timely responses than those considered to have lower safety relevance. The aim of this study was to explore factors that are likely to influence perceptions of risk and safety regarding changing visual information in the driving environment. Factors explored were the environment in which the change occurs (i.e., urban vs. rural), the type of object that changes, and the driver's age, experience, and risk sensitivity. Sixty-three licensed drivers aged 18-70 years completed a hazard rating task, which required them to rate the perceived hazardousness of changing specific elements within urban and rural driving environments. Three attributes of potential hazards were systematically manipulated: the environment (urban, rural); the type of object changed (road sign, car, motorcycle, pedestrian, traffic light, animal, tree); and its inherent safety risk (low risk, high risk). Inherent safety risk was manipulated by either varying the object's placement, on/near or away from the road, or altering an infrastructure element that would require a change to driver behavior. Participants also completed two driving-related risk perception tasks, rating their relative crash risk and perceived risk of aberrant driving behaviors. Driver age was not significantly associated with hazard ratings, but individual differences in perceived risk of aberrant driving behaviors predicted hazard ratings, suggesting that general driving-related risk sensitivity plays a strong role in safety perception. In both urban and rural scenes, there were significant associations between hazard ratings and inherent safety risk, with low-risk changes perceived as consistently less hazardous than high

  9. Features of construction of the training process skiers aged 17-18 years to compete in different styles of skiing

    Directory of Open Access Journals (Sweden)

    T.V. Sidorova

    2013-05-01

    Full Text Available The work is devoted to the improvement of precompetitive preparation of skiers, taking into account the need to participate in competitions of different styles of skiing. The experiment included 20 athletes aged 17-18 years. Isolated model characteristics of athletes who successfully perform classic and skating style of movement. The range of indicators of physical fitness of athletes, which is the norm for this level of qualification. The technique of constructing precompetitive preparation of athletes on the basis of a combination of style of movement. It was established experimentally that the combination of training sessions during the day improves athletic performance in racing classic and skating style. In this case, primary and secondary occupation to carry out a different style of skiing with a change of their rotation on the next day.

  10. Age

    Science.gov (United States)

    ... adults? How can you reduce anesthesia risks in older patients? Age Age may bring wisdom but it also brings ... Ask your physician to conduct a pre-surgery cognitive test — an assessment of your mental function. The physician can use the results as a ...

  11. Influence of Reinforcement Parameters and Ageing Time on Mechanical Behavior of Novel Al2024/SiC/Red Mud Composites Using Response Surface Methodology

    Science.gov (United States)

    Singh, Jaswinder; Chauhan, Amit

    2017-12-01

    This study investigates the mechanical behavior of aluminum 2024 matrix composites reinforced with silicon carbide and red mud particles. The hybrid reinforcements were successfully incorporated into the alloy matrix using the stir casting process. An orthogonal array based on Taguchi's technique was used to acquire experimental data for mechanical properties (hardness and impact energy) of the composites. The analysis of variance (ANOVA) and response surface methodology (RSM) techniques were used to evaluate the influence of test parameters (reinforcement ratio, particle size and ageing time). The morphological analysis of the surfaces (fractured during impact tests) was conducted to identify the failure mechanism. Finally, a confirmation experiment was performed to check the adequacy of the developed model. The results indicate that the ageing time is the most effective parameter as far as the hardness of the hybrid composites is concerned. It has also been revealed that red mud wt.% has maximum influence on the impact energy characteristics of the hybrid composites. The study concludes that Al2024/SiC/red mud hybrid composites possess superior mechanical performance in comparison to pure alloy under optimized conditions.

  12. Orofacial features of subjects aged 18-30 years in the northern part of Kosovo and Metohija territory

    Directory of Open Access Journals (Sweden)

    Todić Jelena

    2016-01-01

    Full Text Available Introduction: Temporomandibular disorder (TMD is a universal term referred to herein to collectively denote a series of functional disorders of orofacial structures, the temporomandibular joint (TMJ and the masticatory muscles in particular. Objectives: The aim of our study was to determine the prevalence of temporomandibular disorders within the observed sample population of the northern part of Kosovo and Metohija, as well as the frequency of signs and symptoms of this type of disorder. Methods: The study involved a sample of 300 subjects, aged 18-30 years. The sample comprised the target student population attending the University of Pristina, Kosovska Mitrovica. A random sample, intended for sampling without replacement, was drawn from the target population. All subjects underwent the Helkimo clinical dysfunction index analysis. Results of the analysis were quantified and expressed numerically, based on severity, as the Helkimo anamnestic dysfunction index (Ai and the clinical dysfunction index (Di with specific values assigned thereto accordingly. Results: The prevalence of temporomandibular disorders within the observed sample population totaled 50.7% (Di> 0. In the majority of patients a mild form of TMP (67% was reported. Temporomandibular disorders were more common in women than in men, who appear to be three times as likely to develop the respective condition, demonstrating the ratio of 3:1. The most common TMD signs and symptoms implied mandibular kinetics disturbances (46% and TMJ sounds (45%. The prevalence of pain during mandibular movements amounted to 9%, the palpable TMJ sensitivity to 20% and the palpable sensitivity of masticatory muscles 18%. Headache and otalgia were represented with 13%, that is, 3% in the observed sample. Conclusion: Temporomandibular disorder analysis demonstrates high incidence in the population of the northern part of Kosovo and Metohija. These findings indicate the need for an extensive prevention

  13. [The specific features of the clinical course of acute suppurative otitis media of viral and mixed viral-bacterial etiology in the children of the preschool age].

    Science.gov (United States)

    Radtsig, E Yu; Bugaichuk, O V

    The objective of the present study was to elucidate the spectrum of the pathogenic agents responsible for the development of acute suppurative otitis media in the children of the preschool age and to reveal the specific clinical features of this disease depending on its etiological factors. The study involved 138 patients (186 ears) of either sex at the age from 1 year to 84 months who presented with acute suppurative otitis media. The following methods were employed for the purpose of the study: analysis of the patients' complaints and the past medical histories, examination of the ENT organs, microbiological (bacteriological and virological) studies of secretion from the tympanic cavity, diagnostic endoscopy of the nasal cavity and nasopharynx, laboratory investigations. The study allowed to reveal the characteristic clinical manifestations of the pathology of interest depending on its etiology.

  14. Meta-analytic review of the development of face discrimination in infancy: Face race, face gender, infant age, and methodology moderate face discrimination.

    Science.gov (United States)

    Sugden, Nicole A; Marquis, Alexandra R

    2017-11-01

    Infants show facility for discriminating between individual faces within hours of birth. Over the first year of life, infants' face discrimination shows continued improvement with familiar face types, such as own-race faces, but not with unfamiliar face types, like other-race faces. The goal of this meta-analytic review is to provide an effect size for infants' face discrimination ability overall, with own-race faces, and with other-race faces within the first year of life, how this differs with age, and how it is influenced by task methodology. Inclusion criteria were (a) infant participants aged 0 to 12 months, (b) completing a human own- or other-race face discrimination task, (c) with discrimination being determined by infant looking. Our analysis included 30 works (165 samples, 1,926 participants participated in 2,623 tasks). The effect size for infants' face discrimination was small, 6.53% greater than chance (i.e., equal looking to the novel and familiar). There was a significant difference in discrimination by race, overall (own-race, 8.18%; other-race, 3.18%) and between ages (own-race: 0- to 4.5-month-olds, 7.32%; 5- to 7.5-month-olds, 9.17%; and 8- to 12-month-olds, 7.68%; other-race: 0- to 4.5-month-olds, 6.12%; 5- to 7.5-month-olds, 3.70%; and 8- to 12-month-olds, 2.79%). Multilevel linear (mixed-effects) models were used to predict face discrimination; infants' capacity to discriminate faces is sensitive to face characteristics including race, gender, and emotion as well as the methods used, including task timing, coding method, and visual angle. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  15. Scenario development methodologies

    International Nuclear Information System (INIS)

    Eng, T.; Hudson, J.; Stephansson, O.

    1994-11-01

    In the period 1981-1994, SKB has studied several methodologies to systematize and visualize all the features, events and processes (FEPs) that can influence a repository for radioactive waste in the future. All the work performed is based on the terminology and basic findings in the joint SKI/SKB work on scenario development presented in the SKB Technical Report 89-35. The methodologies studied are a) Event tree analysis, b) Influence diagrams and c) Rock Engineering Systems (RES) matrices. Each one of the methodologies is explained in this report as well as examples of applications. One chapter is devoted to a comparison between the two most promising methodologies, namely: Influence diagrams and the RES methodology. In conclusion a combination of parts of the Influence diagram and the RES methodology is likely to be a promising approach. 26 refs

  16. Aging

    International Nuclear Information System (INIS)

    Sasaki, Hideo; Kodama, Kazunori; Yamada, Michiko

    1991-01-01

    The hypothesis that exposure to ionizing radiation accelerates the aging process has been actively investigated at ABCC-RERF since 1958, when longitudinal cohort studies of the Adult Health Study (AHS) and the Life Span Study (LSS) were initiated. In their 1975 overall review of aging studies related to the atomic bomb (A-bomb) survivors, Finch and Beebe concluded that while most studies had shown no correlation between aging and radiation exposure, they had not involved the large numbers of subjects required to provide strong evidence for or against the hypothesis. Extending LSS mortality data up to 1978 did not alter the earlier conclusion that any observed life-shortening was associated primarily with cancer induction rather than with any nonspecific cause. The results of aging studies conducted during the intervening 15 years using data from the same populations are reviewed in the present paper. Using clinical, epidemiological, and laboratory techniques, a broad spectrum of aging parameters have been studied, such as postmortem morphological changes, tests of functional capacity, physical tests and measurements, laboratory tests, tissue changes, and morbidity. With respect to the aging process, the overall results have not been consistent and are generally thought to show no relation to radiation exposure. Although some preliminary results suggest a possible radiation-induced increase in atherosclerotic diseases and acceleration of aging in the T-cell-related immune system, further study is necessary to confirm these findings. In the future, applying the latest gerontological study techniques to data collected from subjects exposed 45 years ago to A-bomb radiation at relatively young ages will present a new body of data relevant to the study of late radiation effects. (author) 103 refs

  17. Aging

    International Nuclear Information System (INIS)

    Finch, S.C.; Beebe, G.W.

    1975-01-01

    The hypothesis that ionizing radiation accelerates natural aging has been under investigation at the Atomic Bomb Casualty Commission since 1959. Postmortem observations of morphologic and chemical changes, tests of functional capacity, physical tests and measurements, clinical laboratory tests, tissue changes, morbidity, and mortality have all been examined by ABCC investigators interested in this hypothesis. These studies have been beset with conceptual difficulties centered on the definition and measurement of aging. An empirical approach early led to the calculation of an index of physiologic age as a linear combination of age-related tests of various organ systems. Most studies have been negative but have not involved the large numbers that might be required to provide strong evidence for or against the hypothesis. Mortality, however, has been examined on the basis of a large sample and over the period 1950-1972 had provided no support for the hypothesis of radiation-accelerated aging. Ionizing radiation dose, of course shorten human life, but its life-shortening effect appears to be the result of specific radiation-induced disease, especially neoplasms. The hypothesis is now much less attractive than it was 10-20 years ago but still has some value in stimulating research on aging. The experience of the A-bomb survivors provides an unusual opportunity for a definitive test of the hypothesis. (auth.)

  18. OASIS 2: online application for survival analysis 2 with features for the analysis of maximal lifespan and healthspan in aging research.

    Science.gov (United States)

    Han, Seong Kyu; Lee, Dongyeop; Lee, Heetak; Kim, Donghyo; Son, Heehwa G; Yang, Jae-Seong; Lee, Seung-Jae V; Kim, Sanguk

    2016-08-30

    Online application for survival analysis (OASIS) has served as a popular and convenient platform for the statistical analysis of various survival data, particularly in the field of aging research. With the recent advances in the fields of aging research that deal with complex survival data, we noticed a need for updates to the current version of OASIS. Here, we report OASIS 2 (http://sbi.postech.ac.kr/oasis2), which provides extended statistical tools for survival data and an enhanced user interface. In particular, OASIS 2 enables the statistical comparison of maximal lifespans, which is potentially useful for determining key factors that limit the lifespan of a population. Furthermore, OASIS 2 provides statistical and graphical tools that compare values in different conditions and times. That feature is useful for comparing age-associated changes in physiological activities, which can be used as indicators of "healthspan." We believe that OASIS 2 will serve as a standard platform for survival analysis with advanced and user-friendly statistical tools for experimental biologists in the field of aging research.

  19. Testing methodologies

    Energy Technology Data Exchange (ETDEWEB)

    Bender, M.A.

    1990-01-01

    Several methodologies are available for screening human populations for exposure to ionizing radiation. Of these, aberration frequency determined in peripheral blood lymphocytes is the best developed. Individual exposures to large doses can easily be quantitated, and population exposures to occupational levels can be detected. However, determination of exposures to the very low doses anticipated from a low-level radioactive waste disposal site is more problematical. Aberrations occur spontaneously, without known cause. Exposure to radiation induces no new or novel types, but only increases their frequency. The limitations of chromosomal aberration dosimetry for detecting low level radiation exposures lie mainly in the statistical signal to noise'' problem, the distribution of aberrations among cells and among individuals, and the possible induction of aberrations by other environmental occupational or medical exposures. However, certain features of the human peripheral lymphocyte-chromosomal aberration system make it useful in screening for certain types of exposures. Future technical developments may make chromosomal aberration dosimetry more useful for low-level radiation exposures. Other methods, measuring gene mutations or even minute changes on the DNA level, while presently less will developed techniques, may eventually become even more practical and sensitive assays for human radiation exposure. 15 refs.

  20. Testing methodologies

    International Nuclear Information System (INIS)

    Bender, M.A.

    1990-01-01

    Several methodologies are available for screening human populations for exposure to ionizing radiation. Of these, aberration frequency determined in peripheral blood lymphocytes is the best developed. Individual exposures to large doses can easily be quantitated, and population exposures to occupational levels can be detected. However, determination of exposures to the very low doses anticipated from a low-level radioactive waste disposal site is more problematical. Aberrations occur spontaneously, without known cause. Exposure to radiation induces no new or novel types, but only increases their frequency. The limitations of chromosomal aberration dosimetry for detecting low level radiation exposures lie mainly in the statistical ''signal to noise'' problem, the distribution of aberrations among cells and among individuals, and the possible induction of aberrations by other environmental occupational or medical exposures. However, certain features of the human peripheral lymphocyte-chromosomal aberration system make it useful in screening for certain types of exposures. Future technical developments may make chromosomal aberration dosimetry more useful for low-level radiation exposures. Other methods, measuring gene mutations or even minute changes on the DNA level, while presently less will developed techniques, may eventually become even more practical and sensitive assays for human radiation exposure. 15 refs

  1. Winding up the molecular clock in the genus Carabus (Coleoptera: Carabidae: assessment of methodological decisions on rate and node age estimation

    Directory of Open Access Journals (Sweden)

    Andújar Carmelo

    2012-03-01

    Full Text Available Abstract Background Rates of molecular evolution are known to vary across taxa and among genes, and this requires rate calibration for each specific dataset based on external information. Calibration is sensitive to evolutionary model parameters, partitioning schemes and clock model. However, the way in which these and other analytical aspects affect both the rates and the resulting clade ages from calibrated phylogenies are not yet well understood. To investigate these aspects we have conducted calibration analyses for the genus Carabus (Coleoptera, Carabidae on five mitochondrial and four nuclear DNA fragments with 7888 nt total length, testing different clock models and partitioning schemes to select the most suitable using Bayes Factors comparisons. Results We used these data to investigate the effect of ambiguous character and outgroup inclusion on both the rates of molecular evolution and the TMRCA of Carabus. We found considerable variation in rates of molecular evolution depending on the fragment studied (ranging from 5.02% in cob to 0.26% divergence/My in LSU-A, but also on analytical conditions. Alternative choices of clock model, partitioning scheme, treatment of ambiguous characters, and outgroup inclusion resulted in rate increments ranging from 28% (HUWE1 to 1000% (LSU-B and ITS2 and increments in the TMRCA of Carabus ranging from 8.4% (cox1-A to 540% (ITS2. Results support an origin of the genus Carabus during the Oligocene in the Eurasian continent followed by a Miocene differentiation that originated all main extant lineages. Conclusions The combination of several genes is proposed as the best strategy to minimise both the idiosyncratic behaviors of individual markers and the effect of analytical aspects in rate and age estimations. Our results highlight the importance of estimating rates of molecular evolution for each specific dataset, selecting for optimal clock and partitioning models as well as other methodological issues

  2. Comparison of the Block Kid's Food Frequency Questionnaire with a 24 h dietary recall methodology among Hmong-American children, 9-18 years of age.

    Science.gov (United States)

    Mulasi-Pokhriyal, Urvashi; Smith, Chery

    2013-01-28

    Hmong are one of the immigrant Asian subgroups with increasing rates of obesity, type 2 diabetes and CVD. Despite their population growth in the USA and declining health status, no research has investigated the appropriateness of dietary assessment measures, including FFQ and 24 h dietary recalls among Hmong. The present study compared the nutrient information obtained through a 24 h dietary recall method with that collected using the Block Kid's Food Frequency Questionnaire (Block FFQ) among Hmong-American children (n 335) of 9-18 years of age. For this purpose, two 24 h dietary recalls were collected during non-consecutive days and averaged for comparison. The Block FFQ was administered on the day of the second 24 h recall and the two methodologies were also compared using t tests. Among all children, Block FFQ nutrient estimates for vitamin A, vitamin C and food group servings for vegetables and fruits were significantly higher than those assessed through the 24 h dietary recalls (Pfood group servings for grains and meat and beans were significantly higher among all participants when assessed through the 24 h dietary recalls than through the Block FFQ (Pfood options otherwise missed in the Block FFQ. We recommend the modification of the current Block FFQ to appropriately reflect cultural food/beverage items of the population in interest.

  3. [FEATURES OF CONSTITUTIONAL CHARACTERISTICS OF YOUNG MALES AGED OF 17-20 YEARS, NATIVES OF THE BAIKAL REGION WITH REGARD TO THEIR FUNCTIONAL GROUPS OF HEALTH].

    Science.gov (United States)

    Kolokoltsev, M M

    2016-01-01

    The study of somatotypes of the constitution is an important point in planning of the improvements of measures among the population in various regions of Russia. The purpose of the work was to reveal features of age dynamics of somatotypes of the constitution in students of youthful age of the Baikal Region by means of somatotyping according to scheme by Nikityuk B. A. and Kozlova A.I (1990) with taking into account their functional group of health. There were examined 1286 Slavic young males, natives of the Irkutsk region, aged of 17-20 years, from them, according to data of the medical examination 996 were referred to the 1st (main) and 290--to the 2nd (preparatory) functional group of health for physical exercises. There were established significant differences in somatotypes of the constitution in young men of the 1st and 2nd functional groups of health. In both functional groups there is noted a significant amount of young males with transitional somatotypes that testifies to incompleteness of growth processes of their organism. The obtained results of a somatotyping are used in the educational process for a training individualization on physical culture of students of IRGTU, and also in construction of independent physical--improving programs.

  4. Features of Physical and Neuro-Psychological Development of Children with Low, Very Low and Extremely Low Birth Weight in Different Age Periods of Life

    Directory of Open Access Journals (Sweden)

    I. A. Deev

    2016-01-01

    Full Text Available Analysis of features of physical and neuro-psychological development of children with low, very low and extremely low birth weight in different age periods is carried out according to cohort studies of newborns with different gestational age and birth weight, presented in electronic databases PubMed and Medscape. It is revealed that the overwhelming number of children with low, very low and extremely low birth weight, gain physical and neuro- psychological development impairments, hearing and vision disorders of varying severity, violation of motor function, intelligence and cognitive skills infringement in an older age. In this regard, it is actual not only to develop new neonatal reanimation and intensive care technologies, but also to ensure adequate prevention of preterm birth in the group of women with a high degree of perinatal risk. All this will further allow preventing increase in children with disabling conditions number among premature infants.

  5. Association of socio-economic features, hygienic status, age group and gender with prevalence of waterborne diseases in rawalpindi and islamabad

    International Nuclear Information System (INIS)

    Siddiqui, M.S.; Amin, M.; Amber, M.; Malik, M.W.; Sherwani, S.K

    2012-01-01

    Prevention of waterborne illness is of great concern all over the world. Waterborne diseases represent significant burden of diseases in the globe. Nearly 4% of diseases are attributable to water, sanitation and hygiene, and approximately 2.2 million people die every year due to diarrheal diseases worldwide. This study was carried out to find association of socio-economic features, hygienic status, age groups and gender with prevalence of water borne diseases in Rawalpindi and Islamabad. A research questionnaire was designed with questions related to demographic data, drinking water data and prevalence of water borne disease. The research questionnaire was interviewed to different respondents above 18 years of age randomly selected from different settings of Rawalpindi and Islamabad belonging to different socio-economic statuses. Data was analysed by employing cross tabulation and chi-square test with help of statistical software. The more frequent age group (47%) was 30 to 45 years. Proportion of diarrhea in females and males of middle age group were calculated as 36.11 % and 11.11 %, respectively. The second more frequent reported disease was jaundice with 15.9% of the target population being males and 16.7% females. Diarrhea was observed to be the major waterborne disease constituting 41 % of the population with poor hygiene practices. The hygienic practices were significantly associated with waterborne diseases (P = <0.001). Waterborne diseases were also, associated with financial status (P=0.02) and literacy rate (p=0.03). The current study concludes that improvement in the hygienic conditions and hygienic practices will playa pivotal role to prevent faeco-oral infections and reduce the waterborne disease burden. In targeted areas due to poor economic conditions, the population failed to achieve better hygienic practices and therefore there is a need to strengthen water filtration system and awareness of hygienic routine practices in these areas. (author)

  6. METHODOLOGICAL DEVELOPMENTS IN 3D SCANNING AND MODELLING OF ARCHAEOLOGICAL FRENCH HERITAGE SITE : THE BRONZE AGE PAINTED CAVE OF "LES FRAUX", DORDOGNE (FRANCE

    Directory of Open Access Journals (Sweden)

    A. Burens

    2013-07-01

    Full Text Available For six years, an interdisciplinary team of archaeologists, surveyors, environmentalists and archaeometrists have jointly carried out the study of a Bronze Age painted cave, registrered in the French Historical Monuments. The archaeological cave of Les Fraux (Saint-Martin-de-Fressengeas, Dordogne forms a wide network of galleries, characterized by the exceptional richness of its archaeological remains such as ceramic and metal deposits, parietal representation and about domestic fireplaces. This cave is the only protohistorical site in Europe wherein are gathered testimonies of domestic, spiritual and artistic activities. Fortunately, the cave was closed at the end of the Bronze Age, following to the collapse of its entrance. The site was re-discovered in 1989 and its study started in 2007. The study in progress takes place in a new kind of tool founded by the CNRS's Institute of Ecology and Environment. The purpose of this observatory is the promotion of new methodologies and experimental studies in Global Ecology. In that framework, 3D models of the cave constitute the common work support and the best way for scientific communication for the various studies conducted on the site by nearly forty researchers. In this specific context, a partnership among archaeologists and surveyors from INSA Strasbourg allows the team to develop, in an interdisciplinary way, new methods of data acquiring based on contact-free measurements techniques in order to acquire a full 3D-documentation. This work is conducted in compliance with the integrity of the site. Different techniques based on Terrestrial Laser Scanning, Digital Photogrammetry and Spatial Imaging System have been used in order to generate a geometric and photorealistic 3D model from the combination of point clouds and photogrammetric images, for both visualization and accurate documentation purposes. Various scales of acquiring and diverse resolutions have been applied according to the subject

  7. Local constructions of gender-based violence amongst IDPs in northern Uganda: analysis of archival data collected using a gender- and age-segmented participatory ranking methodology.

    Science.gov (United States)

    Ager, Alastair; Bancroft, Carolyn; Berger, Elizabeth; Stark, Lindsay

    2018-01-01

    Gender-based violence (GBV) is a significant problem in conflict-affected settings. Understanding local constructions of such violence is crucial to developing preventive and responsive interventions to address this issue. This study reports on a secondary analysis of archived data collected as part of formative qualitative work - using a group participatory ranking methodology (PRM) - informing research on the prevalence of GBV amongst IDPs in northern Uganda in 2006. Sixty-four PRM group discussions were held with women, with men, with girls (aged 14 to 18 years), and with boys (aged 14 to 18 years) selected on a randomized basis across four internally displaced persons (IDP) camps in Lira District. Discussions elicited problems facing women in the camps, and - through structured participatory methods - consensus ranking of their importance and narrative accounts explaining these judgments. Amongst forms of GBV faced by women, rape was ranked as the greatest concern amongst participants (with a mean problem rank of 3.4), followed by marital rape (mean problem rank of 4.5) and intimate partner violence (mean problem rank of 4.9). Girls ranked all forms of GBV as higher priority concerns than other participants. Discussions indicated that these forms of GBV were generally considered normalized within the camp. Gender roles and power, economic deprivation, and physical and social characteristics of the camp setting emerged as key explanatory factors in accounts of GBV prevalence, although these played out in different ways with respect to differing forms of violence. All groups acknowledged GBV to represent a significant threat - among other major concerns such as transportation, water, shelter, food and security - for women residing in the camps. Given evidence of the significantly higher risk in the camp of intimate partner violence and marital rape, the relative prominence of the issue of rape in all rankings suggests normalization of violence within the home

  8. The age related slow and fast contributions to the overall changes in tibialis anterior contractile features disclosed by maximal single twitch scan.

    Science.gov (United States)

    Orizio, Claudio; Cogliati, Marta; Bissolotti, Luciano; Diemont, Bertrand; Gobbo, Massimiliano; Celichowski, Jan

    2016-01-01

    This work aimed to verify if maximal electrically evoked single twitch (STmax) scan discloses the relative functional weight of fast and slow small bundles of fibres (SBF) in determining the contractile features of tibialis anterior (TA) with ageing. SBFs were recruited by TA main motor point stimulation through 60 increasing levels of stimulation (LS): 20 stimuli at 2Hz for each LS. The lowest and highest LS provided the least ST and STmax, respectively. The scanned STmax was decomposed into individual SBF STs. They were identified when twitches from adjacent LS were significantly different and then subtracted from each other. Nine young (Y) and eleven old (O) subjects were investigated. Contraction time (CT) and STarea/STpeak (A/PT) were calculated per each SBF ST. 143 and 155 SBF STs were obtained in Y and O, respectively. Y: CT and A/PT range: 45-105ms and 67-183mNs/mN, respectively. Literature data set TA fast fibres at 34% so, from the arrays of CT and A/PT, 65ms and 100mNs/mN were identified as the upper limit for SBF fast ST classification. O: no SBF ST could be classified as fast. STmax scan reveals age-related changes in the relative contribution of fast and slow SBFs to the overall muscle mechanics. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  9. [The anatomical features of the middle ear exerting the influence on the formation of exudative otitis media in the breast-fed infants of different gestational age].

    Science.gov (United States)

    Matroskin, A G; Rakhmanova, I V; Dreval', A A; Kislyakov, A N; Vladimirov, A I

    The objective of the present study was to elucidate the anatomical features of the structure of the middle ear and eustachian tube in the breast-fed infants of different gestational age that may be responsible for the formation of exudates (fluids). We have examined 150 temporal bones obtained from the children's cadavers that were allocated to three groups as follows: 50 temporal bones obtained at weeks 26-30 weeks of gestation (group 1), 44 bones 31-36 weeks of gestation (group 2), and 37-40 weeks of gestation (full-term babies, group 3),The analysis of the data obtained on an individual bases revealed either increase or decreases in the selected characteristics of the eustachian tube in comparison with the respective average values as well as the well apparent predominance of a single change or a combination of alteration of several parameters in one case in 26-30 weeks and 31-36 weeks groups. No significant changes were found in group 1. It is concluded that the presence of a single change or a combination of two or three abnormal changes in the parameters of the bone structures of the eustachian tube can affect the development of the secretory process in the middle ear especially in the children born after 36 weeks of pregnancy.

  10. On methodology

    DEFF Research Database (Denmark)

    Cheesman, Robin; Faraone, Roque

    2002-01-01

    This is an English version of the methodology chapter in the authors' book "El caso Berríos: Estudio sobre información errónea, desinformación y manipulación de la opinión pública".......This is an English version of the methodology chapter in the authors' book "El caso Berríos: Estudio sobre información errónea, desinformación y manipulación de la opinión pública"....

  11. Understanding Legacy Features with Featureous

    DEFF Research Database (Denmark)

    Olszak, Andrzej; Jørgensen, Bo Nørregaard

    2011-01-01

    Java programs called Featureous that addresses this issue. Featureous allows a programmer to easily establish feature-code traceability links and to analyze their characteristics using a number of visualizations. Featureous is an extension to the NetBeans IDE, and can itself be extended by third...

  12. Feature Article

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Feature Article. Articles in Resonance – Journal of Science Education. Volume 1 Issue 1 January 1996 pp 80-85 Feature Article. What's New in Computers Windows 95 · Vijnan Shastri · More Details Fulltext PDF. Volume 1 Issue 1 January 1996 pp 86-89 Feature ...

  13. Aging, Maturation and Growth of Sauropodomorph Dinosaurs as Deduced from Growth Curves Using Long Bone Histological Data: An Assessment of Methodological Constraints and Solutions.

    Science.gov (United States)

    Griebeler, Eva Maria; Klein, Nicole; Sander, P Martin

    2013-01-01

    Information on aging, maturation, and growth is important for understanding life histories of organisms. In extinct dinosaurs, such information can be derived from the histological growth record preserved in the mid-shaft cortex of long bones. Here, we construct growth models to estimate ages at death, ages at sexual maturity, ages at which individuals were fully-grown, and maximum growth rates from the growth record preserved in long bones of six sauropod dinosaur individuals (one indeterminate mamenchisaurid, two Apatosaurus sp., two indeterminate diplodocids, and one Camarasaurus sp.) and one basal sauropodomorph dinosaur individual (Plateosaurus engelhardti). Using these estimates, we establish allometries between body mass and each of these traits and compare these to extant taxa. Growth models considered for each dinosaur individual were the von Bertalanffy model, the Gompertz model, and the logistic model (LGM), all of which have inherently fixed inflection points, and the Chapman-Richards model in which the point is not fixed. We use the arithmetic mean of the age at the inflection point and of the age at which 90% of asymptotic mass is reached to assess respectively the age at sexual maturity or the age at onset of reproduction, because unambiguous indicators of maturity in Sauropodomorpha are lacking. According to an AIC-based model selection process, the LGM was the best model for our sauropodomorph sample. Allometries established are consistent with literature data on other Sauropodomorpha. All Sauropodomorpha reached full size within a time span similar to scaled-up modern mammalian megaherbivores and had similar maximum growth rates to scaled-up modern megaherbivores and ratites, but growth rates of Sauropodomorpha were lower than of an average mammal. Sauropodomorph ages at death probably were lower than that of average scaled-up ratites and megaherbivores. Sauropodomorpha were older at maturation than scaled-up ratites and average mammals, but

  14. Aging, Maturation and Growth of Sauropodomorph Dinosaurs as Deduced from Growth Curves Using Long Bone Histological Data: An Assessment of Methodological Constraints and Solutions.

    Directory of Open Access Journals (Sweden)

    Eva Maria Griebeler

    Full Text Available Information on aging, maturation, and growth is important for understanding life histories of organisms. In extinct dinosaurs, such information can be derived from the histological growth record preserved in the mid-shaft cortex of long bones. Here, we construct growth models to estimate ages at death, ages at sexual maturity, ages at which individuals were fully-grown, and maximum growth rates from the growth record preserved in long bones of six sauropod dinosaur individuals (one indeterminate mamenchisaurid, two Apatosaurus sp., two indeterminate diplodocids, and one Camarasaurus sp. and one basal sauropodomorph dinosaur individual (Plateosaurus engelhardti. Using these estimates, we establish allometries between body mass and each of these traits and compare these to extant taxa. Growth models considered for each dinosaur individual were the von Bertalanffy model, the Gompertz model, and the logistic model (LGM, all of which have inherently fixed inflection points, and the Chapman-Richards model in which the point is not fixed. We use the arithmetic mean of the age at the inflection point and of the age at which 90% of asymptotic mass is reached to assess respectively the age at sexual maturity or the age at onset of reproduction, because unambiguous indicators of maturity in Sauropodomorpha are lacking. According to an AIC-based model selection process, the LGM was the best model for our sauropodomorph sample. Allometries established are consistent with literature data on other Sauropodomorpha. All Sauropodomorpha reached full size within a time span similar to scaled-up modern mammalian megaherbivores and had similar maximum growth rates to scaled-up modern megaherbivores and ratites, but growth rates of Sauropodomorpha were lower than of an average mammal. Sauropodomorph ages at death probably were lower than that of average scaled-up ratites and megaherbivores. Sauropodomorpha were older at maturation than scaled-up ratites and average

  15. Methodological guidelines

    International Nuclear Information System (INIS)

    Halsnaes, K.; Callaway, J.M.; Meyer, H.J.

    1999-01-01

    The guideline document establishes a general overview of the main components of climate change mitigation assessment. This includes an outline of key economic concepts, scenario structure, common assumptions, modelling tools and country study assumptions. The guidelines are supported by Handbook Reports that contain more detailed specifications of calculation standards, input assumptions and available tools. The major objectives of the project have been provided a methodology, an implementing framework and a reporting system which countries can follow in meeting their future reporting obligations under the FCCC and for GEF enabling activities. The project builds upon the methodology development and application in the UNEP National Abatement Coasting Studies (UNEP, 1994a). The various elements provide countries with a road map for conducting climate change mitigation studies and submitting national reports as required by the FCCC. (au) 121 refs

  16. Methodological guidelines

    Energy Technology Data Exchange (ETDEWEB)

    Halsnaes, K.; Callaway, J.M.; Meyer, H.J.

    1999-04-01

    The guideline document establishes a general overview of the main components of climate change mitigation assessment. This includes an outline of key economic concepts, scenario structure, common assumptions, modelling tools and country study assumptions. The guidelines are supported by Handbook Reports that contain more detailed specifications of calculation standards, input assumptions and available tools. The major objectives of the project have been provided a methodology, an implementing framework and a reporting system which countries can follow in meeting their future reporting obligations under the FCCC and for GEF enabling activities. The project builds upon the methodology development and application in the UNEP National Abatement Coasting Studies (UNEP, 1994a). The various elements provide countries with a road map for conducting climate change mitigation studies and submitting national reports as required by the FCCC. (au) 121 refs.

  17. A randomised controlled trial investigating the effect of nutritional supplementation on visual function in normal, and age-related macular disease affected eyes: design and methodology [ISRCTN78467674

    Directory of Open Access Journals (Sweden)

    Eperjesi Frank

    2003-10-01

    Full Text Available Abstract Background Age-related macular disease is the leading cause of blind registration in the developed world. One aetiological hypothesis involves oxidation, and the intrinsic vulnerability of the retina to damage via this process. This has prompted interest in the role of antioxidants, particularly the carotenoids lutein and zeaxanthin, in the prevention and treatment of this eye disease. Methods The aim of this randomised controlled trial is to determine the effect of a nutritional supplement containing lutein, vitamins A, C and E, zinc, and copper on measures of visual function in people with and without age-related macular disease. Outcome measures are distance and near visual acuity, contrast sensitivity, colour vision, macular visual field, glare recovery, and fundus photography. Randomisation is achieved via a random number generator, and masking achieved by third party coding of the active and placebo containers. Data collection will take place at nine and 18 months, and statistical analysis will employ Student's t test. Discussion A paucity of treatment modalities for age-related macular disease has prompted research into the development of prevention strategies. A positive effect on normals may be indicative of a role of nutritional supplementation in preventing or delaying onset of the condition. An observed benefit in the age-related macular disease group may indicate a potential role of supplementation in prevention of progression, or even a degree reversal of the visual effects caused by this condition.

  18. MIRD methodology

    International Nuclear Information System (INIS)

    Rojo, Ana M.; Gomez Parada, Ines

    2004-01-01

    The MIRD (Medical Internal Radiation Dose) system was established by the Society of Nuclear Medicine of USA in 1960 to assist the medical community in the estimation of the dose in organs and tissues due to the incorporation of radioactive materials. Since then, 'MIRD Dose Estimate Report' (from the 1 to 12) and 'Pamphlets', of great utility for the dose calculations, were published. The MIRD system was planned essentially for the calculation of doses received by the patients during nuclear medicine diagnostic procedures. The MIRD methodology for the absorbed doses calculations in different tissues is explained

  19. PSA methodology

    Energy Technology Data Exchange (ETDEWEB)

    Magne, L

    1997-12-31

    The purpose of this text is first to ask a certain number of questions on the methods related to PSAs. Notably we will explore the positioning of the French methodological approach - as applied in the EPS 1300{sup 1} and EPS 900{sup 2} PSAs - compared to other approaches (Part One). This reflection leads to more general reflection: what contents, for what PSA? This is why, in Part Two, we will try to offer a framework for definition of the criteria a PSA should satisfy to meet the clearly identified needs. Finally, Part Three will quickly summarize the questions approached in the first two parts, as an introduction to the debate. 15 refs.

  20. PSA methodology

    International Nuclear Information System (INIS)

    Magne, L.

    1996-01-01

    The purpose of this text is first to ask a certain number of questions on the methods related to PSAs. Notably we will explore the positioning of the French methodological approach - as applied in the EPS 1300 1 and EPS 900 2 PSAs - compared to other approaches (Part One). This reflection leads to more general reflection: what contents, for what PSA? This is why, in Part Two, we will try to offer a framework for definition of the criteria a PSA should satisfy to meet the clearly identified needs. Finally, Part Three will quickly summarize the questions approached in the first two parts, as an introduction to the debate. 15 refs

  1. Dosimetric methodology of the ICRP

    International Nuclear Information System (INIS)

    Eckerman, K.F.

    1994-01-01

    Establishment of guidance for the protection of workers and members of the public from radiation exposures necessitates estimation of the radiation dose to tissues of the body at risk. The dosimetric methodology formulated by the International Commission on Radiological Protection (ICRP) is intended to be responsive to this need. While developed for radiation protection, elements of the methodology are often applied in addressing other radiation issues; e.g., risk assessment. This chapter provides an overview of the methodology, discusses its recent extension to age-dependent considerations, and illustrates specific aspects of the methodology through a number of numerical examples

  2. The French national survey on food consumption of children under 3 years of age - Nutri-Bébé 2013: design, methodology, population sampling and feeding practices.

    Science.gov (United States)

    Chouraqui, Jean-Pierre; Tavoularis, Gabriel; Emery, Yves; Francou, Aurée; Hébel, Pascale; Bocquet, Magali; Hankard, Régis; Turck, Dominique

    2018-02-01

    To update the data on food consumption and practices in children under 3 years of age in metropolitan France. The Nutri-Bébé 2013 cross-sectional study selected a random sample, according to the quota sampling method. After giving their informed consent, parents had to record the food consumption during three non-consecutive days framed by two face-to-face interviews, using for quantitative information different portion size measurement aids. One thousand one hundred and eighty-four children were enrolled. Mothers' mean age was 30·8 (sd 5·4) years; 38 % were primiparous; 89 % lived with a partner; 60 % had an occupation. Of the infants younger than 4 months, 31 % were breast-fed. One thousand and thirty-five children consumed infant formula followed by growing-up milk in 63 % of them; solid foods were introduced at a mean age of 5·4 (sd 2·13) months. From 8 months onwards, 25 % of children consumed the same foods as their parents on a more or less regular basis; 29 % ate in front of a screen, with a daily average screen time of 43·0 (sd 40·4) min. This robust survey highlights the low prevalence and duration of breast-feeding in France and shows a modest improvement since the previous survey of 2005 in the observance of recommendations concerning other feeding practices. The frequent consumption of adult foods and the screen time are of concern.

  3. PASSI d'Argento (Silver Steps): the main features of the new nationwide surveillance system for the ageing Italian population, Italy 2013-2014.

    Science.gov (United States)

    Contoli, Benedetta; Carrieri, Patrizia; Masocco, Maria; Penna, Luana; Perra, Alberto

    2016-01-01

    Italy is particularly concerned by population ageing. The costs for society are substantial. In this context a national, representative surveillance system, Passi D'Argento (PDA), was implemented in 2009 to monitor "active aging" and health status in people aged over 64 and to develop preventive health programs to reduce frailty. PDA recruited a representative sample of 24 129 individuals (March 2012-January 2013) aged over 64 who were interviewed by trained staff using a standardized questionnaire. The PDA collects information about participation in society and employment, independent living, health conditions, safety and living environment. Indicator values are used to obtain population health profiles and to compare different LHUs' profiles within the same region or between different regions. The PDA surveillance system proved to be feasible and to be a powerful and innovative local and national tool for monitoring health status, frailty in Italy's elderly population and the essential levels of care currently provided to the elderly.

  4. Methodological study of aging effects on fuel cells using X-ray synchrotron radiography and tomography; Methodische Untersuchung von Alterungseffekten an Brennstoffzellen mittels Synchrotronradiografie und -tomografie

    Energy Technology Data Exchange (ETDEWEB)

    Arlt, Tobias

    2012-04-05

    In the present work, new and advanced methods for the investigation of methanol and hydrogen powered fuel cells were analyzed. Synchrotron radiography and tomography were applied to investigate materials and transport processes in operating fuel cells ''in-situ'' and non-destructively. The corrosion of ruthenium is a key issue during aging of direct methanol fuel cells (DMFC). Therefore the influence of different aging processes on the distribution of ruthenium is of great interesting. An imaging method based on X-ray absorption spectroscopy (XAS) was applied to investigate the changes in the distribution of fuel cell catalysts three-dimensionally. Using monoenergetic synchrotron radiation it was shown that the distribution of ruthenium (Ru) in the anode catalyst changes after application of an accelerated aging procedure. A strong influence on the flowfield and the gas diffusion layer structures on the Ru distribution were found in the gas diffusion electrode at the anode side. Additionally some ruthenium moves through the membrane from the anode to the cathode. The redistribution caused by the accelerated aging procedure strongly differs from that obtained after aging under realistic stack operation (here over 1700 h) of a fuel cell in a pallet transporter. For the tomographic investigations samples were taken out from a stack operation in aged membrane electrode assembly (MEA) and were analyzed ex-situ. It was shown that the Ru redistribution can be attributed to mass transport processes (CO{sub 2} and H{sub 2}O) in the gas diffusion layer (GDL). Other high energy resolved measurements showed that the strength of the oxidation of ruthenium and platinum depends on the spatial distribution of the ruthenium. Last mentioned - also for the platinum catalyst - could be given quantitatively by means of this newly developed method. In the second part of this work high temperature polymer electrolyte fuel cells (HT-PEFC) were investigated. No liquid

  5. Metodologia alternativa para condução do teste de envelhecimento acelerado em sementes de milho Alternative methodology for the accelerated aging test for corn seeds

    Directory of Open Access Journals (Sweden)

    Sonia Regina Mudrovitsch de Bittencourt

    2012-08-01

    Full Text Available Os testes de vigor são rotineiramente empregados em programas internos de controle de qualidade por empresas sementeiras. Para tanto, é necessária a escolha de métodos eficientes que possibilitem a obtenção de respostas rápidas para a tomada de decisões relacionadas ao manuseio, descarte e comercialização dos lotes de sementes. A pesquisa objetivou verificar a redução do período de execução do teste de envelhecimento acelerado (EA em sementes de milho, empregando-se, para a avaliação do desempenho das sementes após o envelhecimento, o teste de tetrazólio - TZ (viabilidade e vigor em substituição ao de germinação (TG em 10 lotes de sementes de sete genótipos de milho, com e sem tratamento fungicida. Os dados obtidos com a metodologia proposta (EA+TZ foram comparados com os valores determinados pelo teste de envelhecimento acelerado realizado com a metodologia tradicional (EA+TG. O uso do teste de tetrazólio (vigor, associado ao teste de envelhecimento acelerado, possibilitou a obtenção de informações semelhantes às fornecidas pelo teste de germinação empregado para o mesmo fim, reduzindo de oito para três dias o tempo necessário para a obtenção dos resultados em sementes de milho.Some vigor tests are routinely used by seed industry for internal programs of seed quality control. Then, it is requested the use of efficient methods to obtain quick answers to take right decisions related to the management, discard and trade of seed lots. This research was carried out in order to study the possibility to short the period to get the accelerated aging test (AA results, using the tetrazolium test (TZ instead of germination test (GT to evaluate the seed performance after the seed aging. Tem corn seed lots were used, with and without fungicide treatment. The data obtained using the alternative method (AA+TZ were compared with those determined by the traditional one (AA+GT. There was discrimination among seed lots using

  6. Feature Extraction

    CERN Document Server

    CERN. Geneva

    2015-01-01

    Feature selection and reduction are key to robust multivariate analyses. In this talk I will focus on pros and cons of various variable selection methods and focus on those that are most relevant in the context of HEP.

  7. Solar Features

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Collection includes a variety of solar feature datasets contributed by a number of national and private solar observatories located worldwide.

  8. Site Features

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset consists of various site features from multiple Superfund sites in U.S. EPA Region 8. These data were acquired from multiple sources at different times...

  9. Microphysics evolution and methodology

    International Nuclear Information System (INIS)

    Dionisio, J.S.

    1990-01-01

    A few general features of microscopics evolution and their relationship with microscopics methodology are briefly surveyed. Several pluri-disciplinary and interdisciplinary aspects of microscopics research are also discussed in the present scientific context. The need for an equilibrium between individual tendencies and collective constraints required by team work, already formulated thirty years ago by Frederic Joliot, is particularly stressed in the present conjuncture of Nuclear Research favouring very large team projects and discouraging individual initiatives. The increasing importance of the science of science (due to their multiple social, economical, ecological aspects) and the stronger competition between national and international tendencies of scientific (and technical) cooperation are also discussed. (author)

  10. Texture-based characterization of subskin features by specified laser speckle effects at λ = 650 nm region for more accurate parametric 'skin age' modelling.

    Science.gov (United States)

    Orun, A B; Seker, H; Uslan, V; Goodyer, E; Smith, G

    2017-06-01

    The textural structure of 'skin age'-related subskin components enables us to identify and analyse their unique characteristics, thus making substantial progress towards establishing an accurate skin age model. This is achieved by a two-stage process. First by the application of textural analysis using laser speckle imaging, which is sensitive to textural effects within the λ = 650 nm spectral band region. In the second stage, a Bayesian inference method is used to select attributes from which a predictive model is built. This technique enables us to contrast different skin age models, such as the laser speckle effect against the more widely used normal light (LED) imaging method, whereby it is shown that our laser speckle-based technique yields better results. The method introduced here is non-invasive, low cost and capable of operating in real time; having the potential to compete against high-cost instrumentation such as confocal microscopy or similar imaging devices used for skin age identification purposes. © 2016 Society of Cosmetic Scientists and the Société Française de Cosmétologie.

  11. Muscle contractile and metabolic dysfunction is a common feature of sarcopenia of aging and chronic diseases: from sarcopenic obesity to cachexia.

    Science.gov (United States)

    Biolo, Gianni; Cederholm, Tommy; Muscaritoli, Maurizio

    2014-10-01

    Skeletal muscle is the most abundant body tissue accounting for many physiological functions. However, muscle mass and functions are not routinely assessed. Sarcopenia is defined as skeletal muscle loss and dysfunction in aging and chronic diseases. Inactivity, inflammation, age-related factors, anorexia and unbalanced nutrition affect changes in skeletal muscle. Mechanisms are difficult to distinguish in individual subjects due to the multifactorial character of the condition. Sarcopenia includes both muscle loss and dysfunction which induce contractile impairment and metabolic and endocrine abnormalities, affecting whole-body metabolism and immune/inflammatory response. There are different metabolic trajectories for muscle loss versus fat changes in aging and chronic diseases. Appetite regulation and physical activity affect energy balance and changes in body fat mass. Appetite regulation by inflammatory mediators is poorly understood. In some patients, inflammation induces anorexia and fat loss in combination with sarcopenia. In others, appetite is maintained, despite activation of systemic inflammation, leading to sarcopenia with normal or increased BMI. Inactivity contributes to sarcopenia and increased fat tissue in aging and diseases. At the end of the metabolic trajectories, cachexia and sarcopenic obesity are paradigms of the two patient categories. Pre-cachexia and cachexia are observed in patients with cancer, chronic heart failure or liver cirrhosis. Sarcopenic obesity and sarcopenia with normal/increased BMI are observed in rheumatoid arthritis, breast cancer patients with adjuvant chemotherapy and in most of patients with COPD or chronic kidney disease. In these conditions, sarcopenia is a powerful prognostic factor for morbidity and mortality, independent of BMI. Copyright © 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

  12. N-Terminal pro-Brain Natriuretic Peptide and Associations With Brain Magnetic Resonance Imaging (MRI Features in Middle Age: The CARDIA Brain MRI Study

    Directory of Open Access Journals (Sweden)

    Ian T. Ferguson

    2018-05-01

    Full Text Available ObjectiveAs part of research on the heart–brain axis, we investigated the association of N-terminal pro-brain natriuretic peptide (NT-proBNP with brain structure and function in a community-based cohort of middle-aged adults from the Brain Magnetic Resonance Imaging sub-study of the Coronary Artery Risk Development in Young Adults (CARDIA Study.Approach and resultsIn a cohort of 634 community-dwelling adults with a mean (range age of 50.4 (46–52 years, we examined the cross-sectional association of NT-proBNP to total, gray (GM and white matter (WM volumes, abnormal WM load and WM integrity, and to cognitive function tests [the Digit Symbol Substitution Test (DSST, the Stroop test, and the Rey Auditory–Verbal Learning Test]. These associations were examined using linear regression models adjusted for demographic and cardiovascular risk factors and cardiac output. Higher NT-proBNP concentration was significantly associated with smaller GM volume (β = −3.44; 95% CI = −5.32, −0.53; p = 0.003, even after additionally adjusting for cardiac output (β = −2.93; 95% CI = −5.32, −0.53; p = 0.017. Higher NT-proBNP levels were also associated with lower DSST scores. NT-proBNP was not related to WM volume, WM integrity, or abnormal WM load.ConclusionIn this middle-aged cohort, subclinical levels of NT-proBNP were related to brain function and specifically to GM and not WM measures, extending similar findings in older cohorts. Further research is warranted into biomarkers of cardiac dysfunction as a target for early markers of a brain at risk.

  13. [Age-related characteristics of the surface bioelectrical potential of human, canine and rat teeth and features of its distribution over the surface of the crown].

    Science.gov (United States)

    Donskiĭ, G I; Pavliuchenko, O N; Palamarchuk, Iu N; Makarova, N Ia

    1989-01-01

    Using a digital electron voltmeter, bioelectrical potentials (BEPs) of dental crowns have been recorded in 180 patients, 36 dogs, and 93 white non-inbred rats. It has been established that the surface BEP is a marker of dental enamel maturation and does not depend on the species of mammals. On the other hand maturation processes differ in their rate on the cutting edge, equator, and neck: with advancing age algebraic difference between the magnitudes of surface BEPs decreases in humans and increases in dogs and rats.

  14. Clinical features of recently diagnosed papillary thyroid carcinoma in elderly patients aged 65 and older based on 10 years of sonographic experience at a single institution in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Eun Sil; Lee, Young Hen; Seo, Hyun Suk [Dept. of Korea University Ansan Hospital, Korea University College of Medicine, Ansan (Korea, Republic of); and others

    2017-10-15

    The aim of this study was to assess the characteristics of papillary thyroid carcinoma (PTC) in patients aged 65 and older in order to predict postoperative recurrence based on the results of ultrasonographic surveillance. Among 1,494 patients (200 male and 1,294 female; mean age, 46.6±11.3 years) who underwent surgery for thyroid cancer at our institution between 2006 and 2015, we retrospectively enrolled 150 PTC patients (29 male and 121 female; mean age, 69.4±4.2 years). To identify the risk factors for recurrence, we analyzed age, gender, multiplicity, size, number, extrathyroidal extension (ETE) of the tumor, lymph node metastasis (LNM), type of surgery, and the dose of radioactive ablation using a Cox regression model to identify hazard ratios (HRs). Among the 115 asymptomatic patients with PTCs detected by screening ultrasonography (n=86), other cross-sectional imaging modalities (computed tomography or positron emission tomography-computed tomography, n=13), or incidentally through a surgical specimen (n=16), 78 patients were confirmed to have papillary thyroid microcarcinomas (PTMCs). The other 35 patients presented with palpable neck masses (n=25), vocal cord palsy (n=9) or blood-tinged sputum (n=1). During the follow-up period (mean, 43.6 months), 17 patients (12.5%) experienced recurrence in the neck. None of the patients died due to PTC-related recurrence or distant metastasis during the follow-up period. Cox regression analysis demonstrated that tumor size (HR, 2.12; P<0.001) and LNM (central LNM: HR, 9.08; P=0.004; lateral LNM: HR, 14.71; P=0.002; both central and lateral LNM: HR, 58.41; P<0.001) significantly increased the recurrence rate. ETE, LNM, and recurrence were significantly less frequent in PTMCs than in non-PTMC (all P<0.001). PTCs of small size and absent LNM showed significantly better prognoses in patients 65 years and older.

  15. The Role of mf-ERG in the Diagnosis and Treatment of Age-Related Macular Degeneration: Electrophysiological Features of AMD.

    Science.gov (United States)

    Moschos, Marilita M; Nitoda, Eirini

    2018-01-01

    Age-related macular cegeneration (AMD) is the leading cause of visual dysfunction worldwide, affecting 9-25% of individuals between 65 and 75 years old. We have reviewed the published articles investigating the role of multifocal electroretinogram (mf-ERG) in the diagnosis and treatment of AMD. Visual evoked potentials have revealed decreased amplitudes and higher latencies in patients with AMD, while the degeneration of photoreceptors and abnormalities of retinal pigment epithelium can be identified by electro-oculogram recordings. Moreover, ERG can detect the functional abnormalities observed in AMD and evaluate each therapeutic approach. The record of local electrophysiological responses coming from different retinal areas can be accurately performed by mfERG. The accuracy of mfERG in detecting the degeneration of photoreceptors, as well the disturbances of macular function, could be useful both in the early diagnosis of AMD and the assessment of treatment efficacy.

  16. Epidemiological and clinical features of rotavirus among children younger than 5 years of age hospitalized with acute gastroenteritis in Northern Italy

    Directory of Open Access Journals (Sweden)

    Montrasio Giovanni

    2010-07-01

    Full Text Available Abstract Background Rotavirus is the major cause of acute gastroenteritis and severe dehydrating diarrhea in young children. Methods To estimate the proportion of hospital admissions for rotavirus acute gastroenteritis and identify the circulating G and P genotypes among children under five years of age, we conducted a prospective observational study from January to December 2008, recruiting children consecutively admitted to six hospitals in Milan and nearby towns in northern Italy. Typing was done on stool samples by reverse transcriptase polymerase chain reaction amplification. Results Of the 521 stool samples from children with acute gastroenteritis, 34.9% (95%CI, 30.8 to 39.2% were rotavirus-positive. Two thirds (67.6% were under two years of age, and 13.2% were under six months. The predominant G type was G1 (40.7%, followed by G9 (22.5%, G2 (13.2%, G3 (5.5%, G4 (3.8% and G10 (1.6%. Twenty-one (11.7% mixed-G infections were identified: G1+G10 (8.8%; G1+G9 (1.6%; and G2+G10 (1.2%. Only P[8] (67.6% and P[4] (12.6% types were P genotyped. The predominant single G/P combination was G1P[8] (39.7%, followed by G9P[8] (25.3%, G2P[4] (14.3%, and G3P[8] (4.1%. All G-mixed types combined with P[8]. Conclusions These findings show an high prevalence of rotavirus infections among children admitted to hospital for acute gastroenteritis caused by different rotavirus strains circulating in the area studied.

  17. Envejecer en Cuba: mucho más que un indicador demográfico. Ageing in Cuba: much more that a demographic feature

    Directory of Open Access Journals (Sweden)

    María Elena Benítez Pérez

    2015-12-01

    Full Text Available El envejecimiento demográfico ha transformado el panorama social en la mayoría de las naciones y requerido de numerosas investigaciones, con enfoques diversos, que lo aborden desde la multidimensionalidad de la sociedad como un fenómeno nuevo y complejo que modificará la agenda de las políticas públicas dirigidas a la población adulta mayor. La familia tiene, en este entramado, un papel predominante en la provisión de cuidados a las personas ancianas. Por eso, el objetivo del presente trabajo estará dirigido a demostrar algunas acciones que la sociedad cubana ha desarrollado para fortalecer la capacidad de las familias cuando alguno de sus miembros es un adulto mayor. Su desarrollo parte de la hipótesis general de que la familia sola no podrá responder a las múltiples repercusiones que acompañan el proceso de envejecimiento poblacional y necesitarán de una mayor atención social. No hay dudas de que, a escala social, se viene produciendo en el país una redefinición de la vejez en la conciencia de las personas. Ello no quiere decir que todo esté resuelto, sino que hay una mayor sensibilidad y se trabaja para atender una situación que el país ya tiene y que se agudizará en los próximos años. Las nuevas experiencias implementadas -sin ser suficientes- han demostrado los beneficios -sin grandes costos- producidos en la calidad de vida de los ancianos y de sus familias. The demographic ageing has transformed the social context in the majority of the nations and requires a quite large number of researches, which focuses on diverse issues that assume it since the multidimensional of the society, as a new and complex phenomenon, that will modify the agenda of public politics targeted to adult old population. The family plays, in this network, a predominant role in the provision of support to the old people. That is why; the aim of the present work is to demonstrate the several actions that the Cuban society has developed, to

  18. Tamsulosin treatment for benign prostatic hyperplasia and risk of severe hypotension in men aged 40-85 years in the United States: risk window analyses using between and within patient methodology.

    Science.gov (United States)

    Bird, Steven T; Delaney, Joseph A C; Brophy, James M; Etminan, Mahyar; Skeldon, Sean C; Hartzema, Abraham G

    2013-11-05

    To characterize risk of hypotension requiring admission to hospital in middle aged and older men treated with tamsulosin for benign prostatic hyperplasia. Population based retrospective cohort study (between patient methodology) and self controlled case series (within patient methodology). Healthcare claims data from the IMS Lifelink database in the United States. Men aged 40-85 years with private US healthcare insurance entering the cohort at their first dispensing for tamsulosin or for a 5α reductase inhibitor (5ARI) between January 2001 and June 2011 after a minimum of six months' enrolment. Hypotension requiring admission to hospital. Cox proportional hazards models estimated rate ratios at time varying intervals during follow-up: weeks 1-4, 5-8, and 9-12 after tamsulosin initiation; weeks 1-4, 5-8, and 9-12 after restarting tamsulosin (after a four week gap); and maintenance tamsulosin treatment (remaining exposed person time). Covariates included age, calendar year, demographics, antihypertensive use, healthcare use, and a Charlson comorbidity score. A self controlled case series, having implicit control for time invariant covariates, was additionally conducted. Among 383,567 new users of study drugs (tamsulosin 297,596; 5ARI 85,971), 2562 admissions to hospital for severe hypotension were identified. The incidence for hypotension was higher for tamsulosin (42.4 events per 10,000 person years) than for 5ARIs (31.3 events per 10,000 person years) or all accrued person time (29.1 events per 10,000 person years). After tamsulosin initiation, the cohort analysis identified an increased rate of hypotension during weeks 1-4 (rate ratio 2.12 (95% confidence interval 1.29 to 3.04)) and 5-8 (1.51 (1.04 to 2.18)), and no significant increase at weeks 9-12. The rate ratio for hypotension also increased at weeks 1-4 (1.84 (1.46 to 2.33)) and 5-8 (1.85 (1.45 to 2.36)) after restarting tamsulosin, as did maintenance tamsulosin treatment (1.19 (1.07 to 1.32)). The self

  19. National All-Age Career Guidance Services: Evidence and Issues

    Science.gov (United States)

    Watts, A. G.

    2010-01-01

    The three major national all-age career guidance services--in New Zealand, Scotland and Wales--have been reviewed using an adaptation of the methodology adopted in the OECD Career Guidance Policy Review. The main features of the three services are summarised, and some key differences and distinctive strengths are outlined. The alternative approach…

  20. AGE-RELATED FEATURES OF PERIPHERAL BLOOD MARKERS IN CHILDREN AND YOUNG ADULTS WITH NORMAL AND PATHOLOGICAL REMODELING OF BONE TISSUE

    Directory of Open Access Journals (Sweden)

    M. V. Dvornichenko

    2016-01-01

    Full Text Available Activities of total alkaline phosphatase (TALP and its bone isoform (BALP was greater in groups of children and adolescents in the late posttraumatic period (pattern of reparative bone remodeling and scoliosis (pathological bone remodeling, than in the control (healthy children and adolescents. The content of collagen type I degradation products (CrossLaps peripheral blood practically was unchanged. Examined group with posttraumatic period had high activity of tartrate-resistant acid phosphatase form (TRACP. TALP activity reached minimum values in all the studied groups. In the process of children growing to 15–18 years old, as compared to 7–10 years old, reducing activity of remodeling was observed under physiological (healthy donors and reparative osteogenesis. It’s changes was recorded by significant decrease of the studied indicators. On the contrary, children 15–18 years old with scoliosis had maximum of the imbalance (activation/inhibition of various signs of osteogenesis of resorptive/synthetic bone processes. Also, for this group we discovered decrease osteocalcin concentration of 4 times in comparison with the group children of 7–10 years old. The detected growth of the correlations number in the correlation matrix of bone remodeling markers in case of scoliosis proposes the reduction of adaptation reserve of 15–18 years old adolescents, suffering from dysplasia of connective tissue. Thus, the pathophysiological and clinical significance of distant markers of bone metabolism screening in peripheral blood the is ambiguous. The interpretation of these indicators is difficult and largely depends on the clinical situation and age of patients. This requires improving the diagnostic approach to assess physiological and pathological remodeling of bone tissue by means of biochemical blood indicators. 

  1. Single-molecule pull-down (SiMPull) for new-age biochemistry: methodology and biochemical applications of single-molecule pull-down (SiMPull) for probing biomolecular interactions in crude cell extracts.

    Science.gov (United States)

    Aggarwal, Vasudha; Ha, Taekjip

    2014-11-01

    Macromolecular interactions play a central role in many biological processes. Protein-protein interactions have mostly been studied by co-immunoprecipitation, which cannot provide quantitative information on all possible molecular connections present in the complex. We will review a new approach that allows cellular proteins and biomolecular complexes to be studied in real-time at the single-molecule level. This technique is called single-molecule pull-down (SiMPull), because it integrates principles of conventional immunoprecipitation with the powerful single-molecule fluorescence microscopy. SiMPull is used to count how many of each protein is present in the physiological complexes found in cytosol and membranes. Concurrently, it serves as a single-molecule biochemical tool to perform functional studies on the pulled-down proteins. In this review, we will focus on the detailed methodology of SiMPull, its salient features and a wide range of biological applications in comparison with other biosensing tools. © 2014 WILEY Periodicals, Inc.

  2. A methodology for developing distributed programs

    NARCIS (Netherlands)

    Ramesh, S.; Mehndiratta, S.L.

    1987-01-01

    A methodology, different from the existing ones, for constructing distributed programs is presented. It is based on the well-known idea of developing distributed programs via synchronous and centralized programs. The distinguishing features of the methodology are: 1) specification include process

  3. Spectral domain OCT versus time domain OCT in the evaluation of macular features related to wet age-related macular degeneration

    Directory of Open Access Journals (Sweden)

    Isola V

    2012-02-01

    Full Text Available Luisa Pierro1, Elena Zampedri1, Paolo Milani2, Marco Gagliardi1, Vincenzo Isola2, Alfredo Pece21Department of Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milano, Italy, 2Fondazione Retina 3000, Milano, ItalyBackground: The aim of this study was to compare the agreement between spectral domain optical coherence tomography (SD OCT and time domain stratus OCT (TD OCT in evaluating macular morphology alterations in wet age-related macular degeneration (AMD.Methods: This retrospective study was performed on 77 eyes of 77 patients with primary or recurring subfoveal choroidal neovascularization secondary to AMD. All patients underwent OCT examination using Zeiss Stratus OCT 3 (Carl Zeiss Meditec Inc, Dublin, CA and Opko OTI Spectral SLO/OCT (Ophthalmic Technologies Inc, Toronto, Canada. In all radial line scans, the presence of intraretinal edema (IRE, serous pigment epithelium detachment (sPED, neurosensory serous retinal detachment (NSRD, epiretinal membrane (EM, inner limiting membrane thickening (ILMT, and hard exudates (HE were evaluated. The degree of matching was quantified by Kappa measure of agreement.Results: The percentage distribution of TD OCT findings versus SD OCT findings was: IRE 36.3% versus 77.9%, sPED 57.1% versus 85.7%, NSRD 38.9% versus 53.2%, EM 10.5% versus 26.3%, ILMT 3.8% versus 32.4%, and HE 6.4% versus 54.5%. The agreement was as follows: sPED: kappa value 0.15; NSRD: kappa value 0.61; IRE: kappa value 0.18; EM: kappa value 0.41; ILMT: kappa value 0.02; HE: kappa value 0.06.Conclusion: The agreement in the evaluation of macular lesions between the two techniques is poor and depends on the lesion considered. SD OCT allows better detection of the alterations typically related to choroidal neovascularization such as IRE, PED, ILM thickening, and HE. Consequently its use should be strongly considered in patients with wet AMD.Keywords: spectral domain, OCT, time domain, macular degeneration, AMD

  4. Oral Health and Aging

    Science.gov (United States)

    ... please turn JavaScript on. Feature: Oral Health and Aging Oral Health and Aging Past Issues / Summer 2016 Table of Contents Jerrold ... they may need. Read More "Oral Health and Aging" Articles Oral Health and Aging / 4 Myths About ...

  5. Evaluation of skin firmness by the DynaSKIN, a novel non-contact compression device, and its use in revealing the efficacy of a skincare regimen featuring a novel anti-ageing ingredient, acetyl aspartic acid.

    Science.gov (United States)

    Kearney, E M; Messaraa, C; Grennan, G; Koeller, G; Mavon, A; Merinville, E

    2017-05-01

    One of the key strategies for anti-ageing in the cosmetics industry today is to target the structural changes responsible for ptosis of the skin, given its impact on age perception. Several objective and non-invasive methods are available to characterise the biomechanical properties of the skin, which are operator-dependent, involving skin contact and providing single-dimensional numerical descriptions of skin behaviour. The research introduces the DynaSKIN, a device using non-contact mechanical pressure in combination with fringe projection to quantify and visualise the skin response in 3-dimensions. We examine the age correlation of the measurements, how they compare with the Cutometer ® , and measure skin dynamics following application of a skincare regimen containing established anti-ageing ingredients. DynaSKIN and Cutometer ® measurements were made on the cheek of 80 Caucasian women (18-64 years). DynaSKIN volume, mean depth and maximum depth parameters were correlated with age and 15 Cutometer ® parameters. Subsequently, the firming efficacy of a skincare regimen featuring acetyl aspartic acid (AAA) and a peptide complex was examined in a cohort of 41 volunteers. DynaSKIN volume, mean depth and maximum depth parameters correlate with age and the Cutometer ® parameters that are associated with the skin relaxation phase (R1, R2, R4, R5, R7 and F3). Furthermore, the DynaSKIN captured significant improvements in skin firmness delivered by the skincare regimen. The DynaSKIN is a novel device capable of capturing skin biomechanics at a high level of specificity and successfully detected the firming properties of a skincare regimen. Its independent measuring principle, consumer relevance and skin firmness 3D visualisation capabilities bring objectivity and novelty to product efficacy substantiation evaluation. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  6. Featuring animacy

    Directory of Open Access Journals (Sweden)

    Elizabeth Ritter

    2015-01-01

    Full Text Available Algonquian languages are famous for their animacy-based grammatical properties—an animacy based noun classification system and direct/inverse system which gives rise to animacy hierarchy effects in the determination of verb agreement. In this paper I provide new evidence for the proposal that the distinctive properties of these languages is due to the use of participant-based features, rather than spatio-temporal ones, for both nominal and verbal functional categories (Ritter & Wiltschko 2009, 2014. Building on Wiltschko (2012, I develop a formal treatment of the Blackfoot aspectual system that assumes a category Inner Aspect (cf. MacDonald 2008, Travis 1991, 2010. Focusing on lexical aspect in Blackfoot, I demonstrate that the classification of both nouns (Seinsarten and verbs (Aktionsarten is based on animacy, rather than boundedness, resulting in a strikingly different aspectual system for both categories. 

  7. Clinical trial methodology

    National Research Council Canada - National Science Library

    Peace, Karl E; Chen, Ding-Geng

    2011-01-01

    ... in the pharmaceutical industry, Clinical trial methodology emphasizes the importance of statistical thinking in clinical research and presents the methodology as a key component of clinical research...

  8. Efficient Generation and Selection of Combined Features for Improved Classification

    KAUST Repository

    Shono, Ahmad N.

    2014-05-01

    This study contributes a methodology and associated toolkit developed to allow users to experiment with the use of combined features in classification problems. Methods are provided for efficiently generating combined features from an original feature set, for efficiently selecting the most discriminating of these generated combined features, and for efficiently performing a preliminary comparison of the classification results when using the original features exclusively against the results when using the selected combined features. The potential benefit of considering combined features in classification problems is demonstrated by applying the developed methodology and toolkit to three sample data sets where the discovery of combined features containing new discriminating information led to improved classification results.

  9. Encuesta Salud, Bienestar y Envejecimiento (SABE: metodología de la encuesta y perfil de la población estudiada The Health, Well-Being, and Aging ("SABE" survey: methodology applied and profile of the study population

    Directory of Open Access Journals (Sweden)

    Cecilia Albala

    2005-06-01

    Full Text Available El presente documento reseña la metodología de la encuesta SABE y los desafíos que impone a la sociedad en general y a los servicios de salud en particular el rápido envejecimiento de la población en América Latina y el Caribe. La Región esta envejeciendo a un ritmo que no se ha observado en el mundo desarrollado, y la evaluación de problemas de salud y discapacidad indica que los adultos mayores están envejeciendo con más limitaciones funcionales y peor salud que sus semejantes en países desarrollados. Además, las redes familiares están cambiando rápidamente y tienen menos capacidad de suplir la falta de protección social institucional. El estudio multicéntrico SABE se creó con el objetivo de evaluar el estado de salud de las personas adultas mayores de siete ciudades de América Latina y el Caribe: Buenos Aires, Argentina; Bridgetown, Barbados; La Habana, Cuba; Montevideo, Uruguay; Santiago, Chile; México, D.F., México y São Paulo, Brasil. La encuesta SABE establece el punto de partida para la investigación sistemática del envejecimiento en zonas urbanas de la Región de América Latina y el Caribe. Se recomienda que estudios de estas características y con este ánimo comparativo se extiendan a otros países, zonas y regiones, para enriquecer el conocimiento sobre las personas adultas mayores.This document outlines the methodology of the Salud, Bienestar y Envejecimiento (Health, Well-Being, and Aging survey (known as the "SABE survey", and it also summarizes the challenges that the rapid aging of the population in Latin America and the Caribbean imposes on society in general and especially on health services. The populations of the countries of Latin America and the Caribbean are aging at a rate that has not been seen in the developed world. The evaluation of health problems and disability among older adults in those countries indicates that those persons are aging with more functional limitations and worse health than

  10. Technical specification optimization program - engineered safety features

    International Nuclear Information System (INIS)

    Andre, G.R.; Jansen, R.L.

    1986-01-01

    The Westinghouse Technical Specification Program (TOP) was designed to evaluate on a quantitative basis revisions to Nuclear Power Plant Technical Specifications. The revisions are directed at simplifying plant operation, and reducing unnecessary transients, shutdowns, and manpower requirements. In conjunction with the Westinghouse Owners Group, Westinghouse initiated a program to develop a methodology to justify Technical Specification revisions; particularly revisions related to testing and maintenance requirements on plant operation for instrumentation systems. The methodology was originally developed and applied to the reactor trip features of the reactor protection system (RPS). The current study further refined the methodology and applied it to the engineered safety features of the RPS

  11. Efficient Generation and Selection of Combined Features for Improved Classification

    KAUST Repository

    Shono, Ahmad N.

    2014-01-01

    This study contributes a methodology and associated toolkit developed to allow users to experiment with the use of combined features in classification problems. Methods are provided for efficiently generating combined features from an original

  12. Unattended Monitoring System Design Methodology

    International Nuclear Information System (INIS)

    Drayer, D.D.; DeLand, S.M.; Harmon, C.D.; Matter, J.C.; Martinez, R.L.; Smith, J.D.

    1999-01-01

    A methodology for designing Unattended Monitoring Systems starting at a systems level has been developed at Sandia National Laboratories. This proven methodology provides a template that describes the process for selecting and applying appropriate technologies to meet unattended system requirements, as well as providing a framework for development of both training courses and workshops associated with unattended monitoring. The design and implementation of unattended monitoring systems is generally intended to respond to some form of policy based requirements resulting from international agreements or domestic regulations. Once the monitoring requirements are established, a review of the associated process and its related facilities enables identification of strategic monitoring locations and development of a conceptual system design. The detailed design effort results in the definition of detection components as well as the supporting communications network and data management scheme. The data analyses then enables a coherent display of the knowledge generated during the monitoring effort. The resultant knowledge is then compared to the original system objectives to ensure that the design adequately addresses the fundamental principles stated in the policy agreements. Implementation of this design methodology will ensure that comprehensive unattended monitoring system designs provide appropriate answers to those critical questions imposed by specific agreements or regulations. This paper describes the main features of the methodology and discusses how it can be applied in real world situations

  13. METHODOLOGICAL ELEMENTS OF SITUATIONAL ANALYSIS

    Directory of Open Access Journals (Sweden)

    Tetyana KOVALCHUK

    2016-07-01

    Full Text Available The article deals with the investigation of theoretical and methodological principles of situational analysis. The necessity of situational analysis is proved in modern conditions. The notion “situational analysis” is determined. We have concluded that situational analysis is a continuous system study which purpose is to identify dangerous situation signs, to evaluate comprehensively such signs influenced by a system of objective and subjective factors, to search for motivated targeted actions used to eliminate adverse effects of the exposure of the system to the situation now and in the future and to develop the managerial actions needed to bring the system back to norm. It is developed a methodological approach to the situational analysis, its goal is substantiated, proved the expediency of diagnostic, evaluative and searching functions in the process of situational analysis. The basic methodological elements of the situational analysis are grounded. The substantiation of the principal methodological elements of system analysis will enable the analyst to develop adaptive methods able to take into account the peculiar features of a unique object which is a situation that has emerged in a complex system, to diagnose such situation and subject it to system and in-depth analysis, to identify risks opportunities, to make timely management decisions as required by a particular period.

  14. Multicriteria methodology for decision aiding

    CERN Document Server

    Roy, Bernard

    1996-01-01

    This is the first comprehensive book to present, in English, the multicriteria methodology for decision aiding In the foreword the distinctive features and main ideas of the European School of MCDA are outlined The twelve chapters are essentially expository in nature, but scholarly in treatment Some questions, which are too often neglected in the literature on decision theory, such as how is a decision made, who are the actors, what is a decision aiding model, how to define the set of alternatives, are discussed Examples are used throughout the book to illustrate the various concepts Ways to model the consequences of each alternative and building criteria taking into account the inevitable imprecisions, uncertainties and indeterminations are described and illustrated The three classical operational approaches of MCDA synthesis in one criterion (including MAUT), synthesis by outranking relations, interactive local judgements, are studied This methodology tries to be a theoretical or intellectual framework dire...

  15. Design methodology of Dutch banknotes

    Science.gov (United States)

    de Heij, Hans A. M.

    2000-04-01

    Since the introduction of a design methodology for Dutch banknotes, the quality of Dutch paper currency has improved in more than one way. The methodology is question provides for (i) a design policy, which helps fix clear objectives; (ii) design management, to ensure a smooth cooperation between the graphic designer, printer, papermaker an central bank, (iii) a program of requirements, a banknote development guideline for all parties involved. This systematic approach enables an objective selection of design proposals, including security features. Furthermore, the project manager obtains regular feedback from the public by conducting market surveys. Each new design of a Netherlands Guilder banknote issued by the Nederlandsche Bank of the past 50 years has been an improvement on its predecessor in terms of value recognition, security and durability.

  16. Odontogenic keratocyst radiographic features

    International Nuclear Information System (INIS)

    Nartey, N. O.; Saini, T.

    1990-01-01

    The clinical features often patients with odontogenic keratocysts were studied. One patient had Gorlin-GoJtz syndrome. A total of fourteen radiolucent lesions were observed on radiographic examination. All the fourteen lesions were diagnosed as odontogenic keratocyst after histopathclogical examination of biopsied tissue from the patients. The age at diagnosis ranged from 25-72 years with a mean age of 37.6 years. The male : female ratio was 2.3:1. Thirteen of these lesions occurred in the mandible, nine involved the mandibular third molar region. Involvement of the ramus of the mandible produced a sausage-shaped radiolucency. Cystic lesions which have been present for long periods of time showed scalloped margins, due to the regional resorption of the surrounding bone. The bony ledges present on the cortical bones simulated multilocular appearance in such cases. It was also observed that the lesions in older individuals perforated the cortical plates rather than eliciting a periostally induced bony expansion. (author)

  17. Dynamic Features for Iris Recognition.

    Science.gov (United States)

    da Costa, R M; Gonzaga, A

    2012-08-01

    The human eye is sensitive to visible light. Increasing illumination on the eye causes the pupil of the eye to contract, while decreasing illumination causes the pupil to dilate. Visible light causes specular reflections inside the iris ring. On the other hand, the human retina is less sensitive to near infra-red (NIR) radiation in the wavelength range from 800 nm to 1400 nm, but iris detail can still be imaged with NIR illumination. In order to measure the dynamic movement of the human pupil and iris while keeping the light-induced reflexes from affecting the quality of the digitalized image, this paper describes a device based on the consensual reflex. This biological phenomenon contracts and dilates the two pupils synchronously when illuminating one of the eyes by visible light. In this paper, we propose to capture images of the pupil of one eye using NIR illumination while illuminating the other eye using a visible-light pulse. This new approach extracts iris features called "dynamic features (DFs)." This innovative methodology proposes the extraction of information about the way the human eye reacts to light, and to use such information for biometric recognition purposes. The results demonstrate that these features are discriminating features, and, even using the Euclidean distance measure, an average accuracy of recognition of 99.1% was obtained. The proposed methodology has the potential to be "fraud-proof," because these DFs can only be extracted from living irises.

  18. Online feature selection with streaming features.

    Science.gov (United States)

    Wu, Xindong; Yu, Kui; Ding, Wei; Wang, Hao; Zhu, Xingquan

    2013-05-01

    We propose a new online feature selection framework for applications with streaming features where the knowledge of the full feature space is unknown in advance. We define streaming features as features that flow in one by one over time whereas the number of training examples remains fixed. This is in contrast with traditional online learning methods that only deal with sequentially added observations, with little attention being paid to streaming features. The critical challenges for Online Streaming Feature Selection (OSFS) include 1) the continuous growth of feature volumes over time, 2) a large feature space, possibly of unknown or infinite size, and 3) the unavailability of the entire feature set before learning starts. In the paper, we present a novel Online Streaming Feature Selection method to select strongly relevant and nonredundant features on the fly. An efficient Fast-OSFS algorithm is proposed to improve feature selection performance. The proposed algorithms are evaluated extensively on high-dimensional datasets and also with a real-world case study on impact crater detection. Experimental results demonstrate that the algorithms achieve better compactness and higher prediction accuracy than existing streaming feature selection algorithms.

  19. The Gañuelas-Mazarrón Tertiary Basin (Murcia, Spain): Features, Analogies, implications for the Safety of a CO2-DGS and Methodology; La Cuenca de Gañuelas-Mazarrón (Murcia, España): Caracteristicas, Analogías, Implicaciones para la Seguridad de un AGP-CO y 2 Metodología de Estudio

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigo-Naharro, J.; Clemente-Jul, C.; Pérez del Villar, L.

    2015-07-01

    This work summarizes the main features of the Gañuelas-Mazarrón Tertiary basin, emphasising on the: i) geological, hydrogeological and hydrogeochemical characteristics; ii) current carbonate precipitation related to waters from several hydrogeological and geothermal wells in the basin; and iii) dissolved and free CO2 leakages and associated gases, mainly 222Rn. Furthermore, it has been summarised the main analogies established between the natural system studied and a CO2-Deep Geological Storage (CO2-DGS) conceptual model; as well as the implications of these analogies to qualitatively analyse the behaviour and evaluate the safety, in short, medium and long term, of a CO2-DGS. Finally, a useful methodology for any sedimentary basin, similar to the Gañuelas-Mazarrón basin, capable to host a CO2-DGS is also proposed. In conclusion, the full or partial study of a natural system analogous to a CO2-DGS must not be confused with the study to characterise a site for a CO2-DGS, since natural analogues should provide information about the behaviour, evolution and safety, in long-term, of the natural system, and that this information could be applied to a CO2-DGS system.

  20. Age-related increase in the fraction of CD27-CD4+ T cells and IL-4 production as a feature of CD4+ T cell differentiation in vivo

    NARCIS (Netherlands)

    Nijhuis, E. W.; Remarque, E. J.; Hinloopen, B.; van der Pouw-Kraan, T.; van Lier, R. A.; Ligthart, G. J.; Nagelkerken, L.

    1994-01-01

    The influence of ageing on phenotype and function of CD4+ T cells was studied by comparing young (19-28 years of age) and aged (75-84 years of age) donors that were selected using the SENIEUR protocol to exclude underlying disease. An age-related increase was observed in the relative number of

  1. Identifying significant environmental features using feature recognition.

    Science.gov (United States)

    2015-10-01

    The Department of Environmental Analysis at the Kentucky Transportation Cabinet has expressed an interest in feature-recognition capability because it may help analysts identify environmentally sensitive features in the landscape, : including those r...

  2. Methodology for Modeling and Analysis of Business Processes (MMABP

    Directory of Open Access Journals (Sweden)

    Vaclav Repa

    2015-10-01

    Full Text Available This paper introduces the methodology for modeling business processes. Creation of the methodology is described in terms of the Design Science Method. Firstly, the gap in contemporary Business Process Modeling approaches is identified and general modeling principles which can fill the gap are discussed. The way which these principles have been implemented in the main features of created methodology is described. Most critical identified points of the business process modeling are process states, process hierarchy and the granularity of process description. The methodology has been evaluated by use in the real project. Using the examples from this project the main methodology features are explained together with the significant problems which have been met during the project. Concluding from these problems together with the results of the methodology evaluation the needed future development of the methodology is outlined.

  3. Reliability Centered Maintenance - Methodologies

    Science.gov (United States)

    Kammerer, Catherine C.

    2009-01-01

    Journal article about Reliability Centered Maintenance (RCM) methodologies used by United Space Alliance, LLC (USA) in support of the Space Shuttle Program at Kennedy Space Center. The USA Reliability Centered Maintenance program differs from traditional RCM programs because various methodologies are utilized to take advantage of their respective strengths for each application. Based on operational experience, USA has customized the traditional RCM methodology into a streamlined lean logic path and has implemented the use of statistical tools to drive the process. USA RCM has integrated many of the L6S tools into both RCM methodologies. The tools utilized in the Measure, Analyze, and Improve phases of a Lean Six Sigma project lend themselves to application in the RCM process. All USA RCM methodologies meet the requirements defined in SAE JA 1011, Evaluation Criteria for Reliability-Centered Maintenance (RCM) Processes. The proposed article explores these methodologies.

  4. Right putamen and age are the most discriminant features to diagnose Parkinson's disease by using 123I-FP-CIT brain SPET data by using an artificial neural network classifier, a classification tree (ClT).

    Science.gov (United States)

    Cascianelli, S; Tranfaglia, C; Fravolini, M L; Bianconi, F; Minestrini, M; Nuvoli, S; Tambasco, N; Dottorini, M E; Palumbo, B

    2017-01-01

    performance CIT" was evaluated. For CIT, the probability of correct classification in patients with PD was 84.19±11.67% (mean±SD) and in N patients 93.48±6.95%. For CIT, the first decision rule provided a value for the right putamen of 2.32±0.16. This means that patients with right putamen values right putamen uptake value was ≥3.02 or if the value for the right putamen was right putamen uptake distribution. These results show that CIT was able to accurately classify PD and non-PD patients by means of 123 I-FP-CIT brain SPET data and provided also cut-off values able to differentially diagnose these groups of patients. Right putamen uptake values resulted as the most discriminant to correctly classify our patients, probably due to a certain number of subjects with initial prevalence of left clinical symptoms. Finally, the selective evaluation of the group of subjects having putamen values ≥2.32 disclosed that age was a further important feature to classify patients for certain right putamen values.

  5. Features of the Manufacturing Vision Development Process

    DEFF Research Database (Denmark)

    Dukovska-Popovska, Iskra; Riis, Jens Ove; Boer, Harry

    2005-01-01

    of action research. The methodology recommends wide participation of people from different hierarchical and functional positions, who engage in a relatively short, playful and creative process and come up with a vision (concept) for the future manufacturing system in the company. Based on three case studies......This paper discusses the key features of the process of Manufacturing Vision Development, a process that enables companies to develop their future manufacturing concept. The basis for the process is a generic five-phase methodology (Riis and Johansen, 2003) developed as a result of ten years...... of companies going through the initial phases of the methodology, this research identified the key features of the Manufacturing Vision Development process. The paper elaborates the key features by defining them, discussing how and when they can appear, and how they influence the process....

  6. An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure.

    Science.gov (United States)

    Hallam, Dean; Collin, Joseph; Bojic, Sanja; Chichagova, Valeria; Buskin, Adriana; Xu, Yaobo; Lafage, Lucia; Otten, Elsje G; Anyfantis, George; Mellough, Carla; Przyborski, Stefan; Alharthi, Sameer; Korolchuk, Viktor; Lotery, Andrew; Saretzki, Gabriele; McKibbin, Martin; Armstrong, Lyle; Steel, David; Kavanagh, David; Lako, Majlinda

    2017-11-01

    Age-related macular degeneration (AMD) is the most common cause of blindness, accounting for 8.7% of all blindness globally. Vision loss is caused ultimately by apoptosis of the retinal pigment epithelium (RPE) and overlying photoreceptors. Treatments are evolving for the wet form of the disease; however, these do not exist for the dry form. Complement factor H polymorphism in exon 9 (Y402H) has shown a strong association with susceptibility to AMD resulting in complement activation, recruitment of phagocytes, RPE damage, and visual decline. We have derived and characterized induced pluripotent stem cell (iPSC) lines from two subjects without AMD and low-risk genotype and two patients with advanced AMD and high-risk genotype and generated RPE cells that show local secretion of several proteins involved in the complement pathway including factor H, factor I, and factor H-like protein 1. The iPSC RPE cells derived from high-risk patients mimic several key features of AMD including increased inflammation and cellular stress, accumulation of lipid droplets, impaired autophagy, and deposition of "drüsen"-like deposits. The low- and high-risk RPE cells respond differently to intermittent exposure to UV light, which leads to an improvement in cellular and functional phenotype only in the high-risk AMD-RPE cells. Taken together, our data indicate that the patient specific iPSC model provides a robust platform for understanding the role of complement activation in AMD, evaluating new therapies based on complement modulation and drug testing. Stem Cells 2017;35:2305-2320. © 2017 The Authors Stem Cells published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.

  7. Comparison of 230Th/234U Dating Results Obtained on Fossil Mollusk Shell from Morocco and Fossil Coral Samples from Egypt. Research of Methodological Criteria to Valid the Measured Age

    International Nuclear Information System (INIS)

    Choukri, A.; Hakam, O.K.; Reyss, J.L.

    2013-01-01

    Radiochemical ages of 126 unrecrystallized coral samples from the Egyptian shoreline and 125 fossil mollusk shell samples from the Atlantic coast of Moroccan High Atlas are discussed.For corals, the obtained ages are in good agreement with the ages reported previously on urecristallized corals except in some sites where some samples are affected by a cementation of younger aragonite.For mollusk shells, the obtained ages are in the most of cases, rejuvenated.This rejuvenation is due eventually to a post-incorporation of secondary uranium that is responsible of the wide dispersion of apparent ages of mollusk shells.

  8. Methodological pluralism and structure of sociological theory

    Directory of Open Access Journals (Sweden)

    N. L. Polyakova

    2015-01-01

    Full Text Available In the paper the historical-sociological analysis is used as a means to show the differences between theoretical and empirical sociology. There exist several, basic traditions in theoretical sociology. The investigation of their competing theoretical and methodological principles carried out in the paper; identify some fundamental features of sociological theory as a whole.

  9. EVOLVING AN EMPIRICAL METHODOLOGY DOR DETERMINING ...

    African Journals Online (AJOL)

    The uniqueness of this approach, is that it can be applied to any forest or dynamic feature on the earth, and can enjoy universal application as well. KEY WORDS: Evolving empirical methodology, innovative mathematical model, appropriate interval, remote sensing, forest environment planning and management. Global Jnl ...

  10. An object-oriented feature-based design system face-based detection of feature interactions

    International Nuclear Information System (INIS)

    Ariffin Abdul Razak

    1999-01-01

    This paper presents an object-oriented, feature-based design system which supports the integration of design and manufacture by ensuring that part descriptions fully account for any feature interactions. Manufacturing information is extracted from the feature descriptions in the form of volumes and Tool Access Directions, TADs. When features interact, both volumes and TADs are updated. This methodology has been demonstrated by developing a prototype system in which ACIS attributes are used to record feature information within the data structure of the solid model. The system implemented in the C++ programming language and embedded in a menu-driven X-windows user interface to the ACIS 3D Toolkit. (author)

  11. Aging changes in immunity

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/004008.htm Aging changes in immunity To use the sharing features ... cells and antibodies that destroy these harmful substances. AGING CHANGES AND THEIR EFFECTS ON THE IMMUNE SYSTEM ...

  12. Introduction to LCA Methodology

    DEFF Research Database (Denmark)

    Hauschild, Michael Z.

    2018-01-01

    In order to offer the reader an overview of the LCA methodology in the preparation of the more detailed description of its different phases, a brief introduction is given to the methodological framework according to the ISO 14040 standard and the main elements of each of its phases. Emphasis...

  13. Methodologies, languages and tools

    International Nuclear Information System (INIS)

    Amako, Katsuya

    1994-01-01

    This is a summary of the open-quotes Methodologies, Languages and Toolsclose quotes session in the CHEP'94 conference. All the contributions to methodologies and languages are relevant to the object-oriented approach. Other topics presented are related to various software tools in the down-sized computing environment

  14. Archetype modeling methodology.

    Science.gov (United States)

    Moner, David; Maldonado, José Alberto; Robles, Montserrat

    2018-03-01

    Clinical Information Models (CIMs) expressed as archetypes play an essential role in the design and development of current Electronic Health Record (EHR) information structures. Although there exist many experiences about using archetypes in the literature, a comprehensive and formal methodology for archetype modeling does not exist. Having a modeling methodology is essential to develop quality archetypes, in order to guide the development of EHR systems and to allow the semantic interoperability of health data. In this work, an archetype modeling methodology is proposed. This paper describes its phases, the inputs and outputs of each phase, and the involved participants and tools. It also includes the description of the possible strategies to organize the modeling process. The proposed methodology is inspired by existing best practices of CIMs, software and ontology development. The methodology has been applied and evaluated in regional and national EHR projects. The application of the methodology provided useful feedback and improvements, and confirmed its advantages. The conclusion of this work is that having a formal methodology for archetype development facilitates the definition and adoption of interoperable archetypes, improves their quality, and facilitates their reuse among different information systems and EHR projects. Moreover, the proposed methodology can be also a reference for CIMs development using any other formalism. Copyright © 2018 Elsevier Inc. All rights reserved.

  15. Menopause and Methodological Doubt

    Science.gov (United States)

    Spence, Sheila

    2005-01-01

    Menopause and methodological doubt begins by making a tongue-in-cheek comparison between Descartes' methodological doubt and the self-doubt that can arise around menopause. A hermeneutic approach is taken in which Cartesian dualism and its implications for the way women are viewed in society are examined, both through the experiences of women…

  16. VEM: Virtual Enterprise Methodology

    DEFF Research Database (Denmark)

    Tølle, Martin; Vesterager, Johan

    2003-01-01

    This chapter presents a virtual enterprise methodology (VEM) that outlines activities to consider when setting up and managing virtual enterprises (VEs). As a methodology the VEM helps companies to ask the right questions when preparing for and setting up an enterprise network, which works...

  17. Data Centric Development Methodology

    Science.gov (United States)

    Khoury, Fadi E.

    2012-01-01

    Data centric applications, an important effort of software development in large organizations, have been mostly adopting a software methodology, such as a waterfall or Rational Unified Process, as the framework for its development. These methodologies could work on structural, procedural, or object oriented based applications, but fails to capture…

  18. The Methodology of Magpies

    Science.gov (United States)

    Carter, Susan

    2014-01-01

    Arts/Humanities researchers frequently do not explain methodology overtly; instead, they "perform" it through their use of language, textual and historic cross-reference, and theory. Here, methodologies from literary studies are shown to add to Higher Education (HE) an exegetical and critically pluralist approach. This includes…

  19. Decontaminate feature for tracking: adaptive tracking via evolutionary feature subset

    Science.gov (United States)

    Liu, Qiaoyuan; Wang, Yuru; Yin, Minghao; Ren, Jinchang; Li, Ruizhi

    2017-11-01

    Although various visual tracking algorithms have been proposed in the last 2-3 decades, it remains a challenging problem for effective tracking with fast motion, deformation, occlusion, etc. Under complex tracking conditions, most tracking models are not discriminative and adaptive enough. When the combined feature vectors are inputted to the visual models, this may lead to redundancy causing low efficiency and ambiguity causing poor performance. An effective tracking algorithm is proposed to decontaminate features for each video sequence adaptively, where the visual modeling is treated as an optimization problem from the perspective of evolution. Every feature vector is compared to a biological individual and then decontaminated via classical evolutionary algorithms. With the optimized subsets of features, the "curse of dimensionality" has been avoided while the accuracy of the visual model has been improved. The proposed algorithm has been tested on several publicly available datasets with various tracking challenges and benchmarked with a number of state-of-the-art approaches. The comprehensive experiments have demonstrated the efficacy of the proposed methodology.

  20. CMOS Active Pixel Sensor Technology and Reliability Characterization Methodology

    Science.gov (United States)

    Chen, Yuan; Guertin, Steven M.; Pain, Bedabrata; Kayaii, Sammy

    2006-01-01

    This paper describes the technology, design features and reliability characterization methodology of a CMOS Active Pixel Sensor. Both overall chip reliability and pixel reliability are projected for the imagers.

  1. Methodology for studying of influence of fire factor on geosystems

    Directory of Open Access Journals (Sweden)

    Yuriy Vasilovyth Buts

    2013-07-01

    Full Text Available Materials about the impact of emergency situations of the technogenic and natural character, caused by fires, on geosystems are presented. Methodological features of researches on fire factor influence on geosystem components are shown.

  2. Design Methodology - Design Synthesis

    DEFF Research Database (Denmark)

    Andreasen, Mogens Myrup

    2003-01-01

    Design Methodology is part of our practice and our knowledge about designing, and it has been strongly supported by the establishing and work of a design research community. The aim of this article is to broaden the reader¿s view of designing and Design Methodology. This is done by sketching...... the development of Design Methodology through time and sketching some important approaches and methods. The development is mainly forced by changing industrial condition, by the growth of IT support for designing, but also by the growth of insight into designing created by design researchers.......ABSTRACT Design Methodology shall be seen as our understanding of how to design; it is an early (emerging late 60ies) and original articulation of teachable and learnable methodics. The insight is based upon two sources: the nature of the designed artefacts and the nature of human designing. Today...

  3. GPS system simulation methodology

    Science.gov (United States)

    Ewing, Thomas F.

    1993-01-01

    The following topics are presented: background; Global Positioning System (GPS) methodology overview; the graphical user interface (GUI); current models; application to space nuclear power/propulsion; and interfacing requirements. The discussion is presented in vugraph form.

  4. Hazard classification methodology

    International Nuclear Information System (INIS)

    Brereton, S.J.

    1996-01-01

    This document outlines the hazard classification methodology used to determine the hazard classification of the NIF LTAB, OAB, and the support facilities on the basis of radionuclides and chemicals. The hazard classification determines the safety analysis requirements for a facility

  5. Nonlinear Image Denoising Methodologies

    National Research Council Canada - National Science Library

    Yufang, Bao

    2002-01-01

    In this thesis, we propose a theoretical as well as practical framework to combine geometric prior information to a statistical/probabilistic methodology in the investigation of a denoising problem...

  6. Clinical trial methodology

    National Research Council Canada - National Science Library

    Peace, Karl E; Chen, Ding-Geng

    2011-01-01

    "Now viewed as its own scientific discipline, clinical trial methodology encompasses the methods required for the protection of participants in a clinical trial and the methods necessary to provide...

  7. A Rigorous Methodology for Analyzing and Designing Plug-Ins

    DEFF Research Database (Denmark)

    Fasie, Marieta V.; Haxthausen, Anne Elisabeth; Kiniry, Joseph

    2013-01-01

    . This paper addresses these problems by describing a rigorous methodology for analyzing and designing plug-ins. The methodology is grounded in the Extended Business Object Notation (EBON) and covers informal analysis and design of features, GUI, actions, and scenarios, formal architecture design, including...... behavioral semantics, and validation. The methodology is illustrated via a case study whose focus is an Eclipse environment for the RAISE formal method's tool suite....

  8. Prevalence of neurological disorders in Al Quseir, Egypt: methodological aspects

    Directory of Open Access Journals (Sweden)

    El-Tallawy H

    2013-09-01

    Full Text Available Hamdy El-Tallawy,1 Wafa Farghaly,1 Nabil Metwally,2 Tarek Rageh,1 Ghaydaa A Shehata,1 Reda Badry,1 Esam El Moselhy,2 Mahmoud Hassan,2 Mohamed M Sayed,3 Ahmed A Abdelwarith,1 Y Hamed,2 I Shaaban,2 Talal Mohamed,4 Mohamed Abd El Hamed,1 MR Kandil1 1Department of Neurology, Faculty of Medicine, Assiut University, Assiut, Egypt; 2Department of Neurology and Public Health, Faculty of Medicine, Al-Azhar University (Assiut branch, Assiut, Egypt; 3Department of Neurology, Faculty of Medicine, Sohag University, Sohag, Egypt; 4Department of Neurology, Faculty of Medicine, Qena University, Qena, Egypt Abstract: Methodology and strategy play a very important role in epidemiological studies. Determination of the study area, geographical features, facilities, difficulties, and key personnel from the same area are important factors for successful methodology. Over 31 months (July 1, 2009 to January 31, 2012, a screening and an examination survey were carried out to ascertain the prevalence of epilepsy, stroke, dementia, cerebellar ataxia, migraine, cerebral palsy, Parkinsonism, chorea, athetosis, dystonia, trigeminal neuralgia, Bell's palsy, multiple sclerosis, spinal cord disorders, and attention deficit hyperactivity disorders in Al Quseir, Red Sea Governorate, Egypt. A total of 33,285 people were screened by three neurologists in a door-to-door manner, including every door, using a standardized Arabic questionnaire to detect any subject with a neurological disorder. The methodological aspects of this project were carried out through eight phases: (1 data collection; (2 preparation; (3 screening; (4 case ascertainment; (5 investigations; (6 classifications; (7 data entry; and (8 statistics and tabulations. The results of this study reveal that the total prevalence of neurological disorders in Al Quseir was 4.6% and higher among females (5.2% than males (3.9%. The highest prevalence was recorded in the elderly population (60+ years [8.0%] and among the age

  9. Understanding Participatory Action Research: A Qualitative Research Methodology Option

    Science.gov (United States)

    MacDonald, Cathy

    2012-01-01

    Participatory Action Research (PAR) is a qualitative research methodology option that requires further understanding and consideration. PAR is considered democratic, equitable, liberating, and life-enhancing qualitative inquiry that remains distinct from other qualitative methodologies (Kach & Kralik, 2006). Using PAR, qualitative features of an…

  10. Qualitative methodology in a psychoanalytic single case study

    DEFF Research Database (Denmark)

    Grünbaum, Liselotte

    features and breaks in psychotherapy investigated. One aim of the study was to contribute to the development of a transparent and systematic methodology for the psychoanalytic case study by application of rigorous qualitative research methodology. To this end, inductive-deductive principles in line...

  11. Methodology of sustainability accounting

    Directory of Open Access Journals (Sweden)

    O.H. Sokil

    2017-03-01

    Full Text Available Modern challenges of the theory and methodology of accounting are realized through the formation and implementation of new concepts, the purpose of which is to meet the needs of users in standard and unique information. The development of a methodology for sustainability accounting is a key aspect of the management of an economic entity. The purpose of the article is to form the methodological bases of accounting for sustainable development and determine its goals, objectives, object, subject, methods, functions and key aspects. The author analyzes the theoretical bases of the definition and considers the components of the traditional accounting methodology. Generalized structural diagram of the methodology for accounting for sustainable development is offered in the article. The complex of methods and principles of sustainable development accounting for systematized and non-standard provisions has been systematized. The new system of theoretical and methodological provisions of accounting for sustainable development is justified in the context of determining its purpose, objective, subject, object, methods, functions and key aspects.

  12. Unsupervised Feature Subset Selection

    DEFF Research Database (Denmark)

    Søndberg-Madsen, Nicolaj; Thomsen, C.; Pena, Jose

    2003-01-01

    This paper studies filter and hybrid filter-wrapper feature subset selection for unsupervised learning (data clustering). We constrain the search for the best feature subset by scoring the dependence of every feature on the rest of the features, conjecturing that these scores discriminate some ir...... irrelevant features. We report experimental results on artificial and real data for unsupervised learning of naive Bayes models. Both the filter and hybrid approaches perform satisfactorily....

  13. Neural Networks Methodology and Applications

    CERN Document Server

    Dreyfus, Gérard

    2005-01-01

    Neural networks represent a powerful data processing technique that has reached maturity and broad application. When clearly understood and appropriately used, they are a mandatory component in the toolbox of any engineer who wants make the best use of the available data, in order to build models, make predictions, mine data, recognize shapes or signals, etc. Ranging from theoretical foundations to real-life applications, this book is intended to provide engineers and researchers with clear methodologies for taking advantage of neural networks in industrial, financial or banking applications, many instances of which are presented in the book. For the benefit of readers wishing to gain deeper knowledge of the topics, the book features appendices that provide theoretical details for greater insight, and algorithmic details for efficient programming and implementation. The chapters have been written by experts ands seemlessly edited to present a coherent and comprehensive, yet not redundant, practically-oriented...

  14. Estimating dose rates to organs as a function of age following internal exposure to radionuclides

    International Nuclear Information System (INIS)

    Leggett, R.W.; Eckerman, K.F.; Dunning, D.E. Jr.; Cristy, M.; Crawford-Brown, D.J.; Williams, L.R.

    1984-03-01

    The AGEDOS methodology allows estimates of dose rates, as a function of age, to radiosensitive organs and tissues in the human body at arbitrary times during or after internal exposure to radioactive material. Presently there are few, if any, radionuclides for which sufficient metabolic information is available to allow full use of all features of the methodology. The intention has been to construct the methodology so that optimal information can be gained from a mixture of the limited amount of age-dependent, nuclide-specific data and the generally plentiful age-dependent physiological data now available. Moreover, an effort has been made to design the methodology so that constantly accumulating metabolic information can be incorporated with minimal alterations in the AGEDOS computer code. Some preliminary analyses performed by the authors, using the AGEDOS code in conjunction with age-dependent risk factors developed from the A-bomb survivor data and other studies, has indicated that the doses and subsequent risks of eventually experiencing radiogenic cancers may vary substantially with age for some exposure scenarios and may be relatively invariant with age for other scenarios. We believe that the AGEDOS methodology provides a convenient and efficient means for performing the internal dosimetry

  15. Application of Agent Methodology in Healthcare Information Systems

    Directory of Open Access Journals (Sweden)

    Reem Abdalla

    2017-02-01

    Full Text Available This paper presents a case study to describe the features and the phases of the two agent methodologies. The Gaia methodology for agent oriented analysis and design, Tropos is a detailed agent oriented software engineering methodology to explore each methodology's ability to present solutions for small problems. Also we provide an attempt to discover whether the methodology is in fact understandable and usable. In addition we were collecting and taking notes of the advantages and weaknesses of these methodologies during the study analysis for each methodology and the relationships among their models. The Guardian Angle: Patient-Centered Health Information System (GA: PCHIS is the personal system to help track, manage, and interpret the subject's health history, and give advice to both patient and provider is used as the case study throughout the paper.

  16. Regional Shelter Analysis Methodology

    Energy Technology Data Exchange (ETDEWEB)

    Dillon, Michael B. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dennison, Deborah [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kane, Jave [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Walker, Hoyt [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Miller, Paul [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-08-01

    The fallout from a nuclear explosion has the potential to injure or kill 100,000 or more people through exposure to external gamma (fallout) radiation. Existing buildings can reduce radiation exposure by placing material between fallout particles and exposed people. Lawrence Livermore National Laboratory was tasked with developing an operationally feasible methodology that could improve fallout casualty estimates. The methodology, called a Regional Shelter Analysis, combines the fallout protection that existing buildings provide civilian populations with the distribution of people in various locations. The Regional Shelter Analysis method allows the consideration of (a) multiple building types and locations within buildings, (b) country specific estimates, (c) population posture (e.g., unwarned vs. minimally warned), and (d) the time of day (e.g., night vs. day). The protection estimates can be combined with fallout predictions (or measurements) to (a) provide a more accurate assessment of exposure and injury and (b) evaluate the effectiveness of various casualty mitigation strategies. This report describes the Regional Shelter Analysis methodology, highlights key operational aspects (including demonstrating that the methodology is compatible with current tools), illustrates how to implement the methodology, and provides suggestions for future work.

  17. The policy trail methodology

    DEFF Research Database (Denmark)

    Holford, John; Larson, Anne; Melo, Susana

    of ‘policy trail’, arguing that it can overcome ‘methodological nationalism’ and link structure and agency in research on the ‘European educational space’. The ‘trail’ metaphor, she suggests, captures the intentionality and the erratic character of policy. The trail connects sites and brings about change......, but – although policy may be intended to be linear, with specific outcomes – policy often has to bend, and sometimes meets insurmountable obstacles. This symposium outlines and develops the methodology, but also reports on research undertaken within a major FP7 project (LLLIght’in’Europe, 2012-15) which made use......In recent years, the “policy trail” has been proposed as a methodology appropriate to the shifting and fluid governance of lifelong learning in the late modern world (Holford et al. 2013, Holford et al. 2013, Cort 2014). The contemporary environment is marked by multi-level governance (global...

  18. The Assessment Methodology RADAR – A Theoretical Approach of a Methodology for Coordinating the Efforts to Improve the Organizational Processes to Achieve Excellence

    Directory of Open Access Journals (Sweden)

    Cristina Raluca Popescu

    2015-05-01

    Full Text Available In the paper “The Assessment Methodology RADAR – A Theoretical Approach of a Methodology for Coordinating the Efforts to Improve the Organizational Processes to Achieve Excellence” the authors present the basic features of the assessment methodology RADAR that is designed to coordinate the efforts to improve the organizational processes in order to achieve excellence.

  19. Changing methodologies in TESOL

    CERN Document Server

    Spiro, Jane

    2013-01-01

    Covering core topics from vocabulary and grammar to teaching, writing speaking and listening, this textbook shows you how to link research to practice in TESOL methodology. It emphasises how current understandings have impacted on the language classroom worldwide and investigates the meaning of 'methods' and 'methodology' and the importance of these for the teacher: as well as the underlying assumptions and beliefs teachers bring to bear in their practice. By introducing you to language teaching approaches, you will explore the way these are influenced by developments in our understanding of l

  20. Creativity in phenomenological methodology

    DEFF Research Database (Denmark)

    Dreyer, Pia; Martinsen, Bente; Norlyk, Annelise

    2014-01-01

    on the methodologies of van Manen, Dahlberg, Lindseth & Norberg, the aim of this paper is to argue that the increased focus on creativity and arts in research methodology is valuable to gain a deeper insight into lived experiences. We illustrate this point through examples from empirical nursing studies, and discuss......Nursing research is often concerned with lived experiences in human life using phenomenological and hermeneutic approaches. These empirical studies may use different creative expressions and art-forms to describe and enhance an embodied and personalised understanding of lived experiences. Drawing...... may support a respectful renewal of phenomenological research traditions in nursing research....

  1. Feature Selection by Reordering

    Czech Academy of Sciences Publication Activity Database

    Jiřina, Marcel; Jiřina jr., M.

    2005-01-01

    Roč. 2, č. 1 (2005), s. 155-161 ISSN 1738-6438 Institutional research plan: CEZ:AV0Z10300504 Keywords : feature selection * data reduction * ordering of features Subject RIV: BA - General Mathematics

  2. Radio drama adaptations: an approach towards an analytical methodology

    NARCIS (Netherlands)

    Huwiler, E.

    2010-01-01

    This article establishes a methodology with which radio drama pieces can be analysed. It thereby integrates all features the art form has to offer: voices, music, noises, but also technical features like cutting and mixing contribute to the narrative that is being told. This approach emphasizes the

  3. Methodological Reflections on Working with Young Children

    DEFF Research Database (Denmark)

    Korn, Matthias

    2009-01-01

    This paper provides methodological reflections on an evolutionary and participatory software development process for designing interactive systems with children of very young age. The approach was put into practice for the design of a software environment for self-directed project management...

  4. Screening for Plant Features

    NARCIS (Netherlands)

    Heijden, van der G.W.A.M.; Polder, G.

    2015-01-01

    In this chapter, an overview of different plant features is given, from (sub)cellular to canopy level. A myriad of methods is available to measure these features using image analysis, and often, multiple methods can be used to measure the same feature. Several criteria are listed for choosing a

  5. Rhabdomyolysis featuring muscular dystrophies.

    Science.gov (United States)

    Lahoria, Rajat; Milone, Margherita

    2016-02-15

    Rhabdomyolysis is a potentially life threatening condition of various etiology. The association between rhabdomyolysis and muscular dystrophies is under-recognized in clinical practice. To identify muscular dystrophies presenting with rhabdomyolysis at onset or as predominant feature. We retrospectively reviewed clinical and laboratory data of patients with a genetically confirmed muscular dystrophy in whom rhabdomyolysis was the presenting or main clinical manifestation. Thirteen unrelated patients (males=6; females=7) were identified. Median age at time of rhabdomyolysis was 18 years (range, 2-47) and median duration between the first episode of rhabdomyolysis and molecular diagnosis was 2 years. Fukutin-related protein (FKRP) muscular dystrophy (n=6) was the most common diagnosis, followed by anoctaminopathy-5 (n=3), calpainopathy-3 (n=2) and dystrophinopathy (n=2). Four patients experienced recurrent rhabdomyolysis. Eight patients were asymptomatic and 3 reported myalgia and exercise intolerance prior to the rhabdomyolysis. Exercise (n=6) and fever (n=4) were common triggers; rhabdomyolysis was unprovoked in 3 patients. Twelve patients required hospitalization. Baseline CK levels were elevated in all patients (median 1200 IU/L; range, 600-3600). Muscular dystrophies can present with rhabdomyolysis; FKRP mutations are particularly frequent in causing such complication. A persistently elevated CK level in patients with rhabdomyolysis warrants consideration for underlying muscular dystrophy. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Localized scleroderma: imaging features

    International Nuclear Information System (INIS)

    Liu, P.; Uziel, Y.; Chuang, S.; Silverman, E.; Krafchik, B.; Laxer, R.

    1994-01-01

    Localized scleroderma is distinct from the diffuse form of scleroderma and does not show Raynaud's phenomenon and visceral involvement. The imaging features in 23 patients ranging from 2 to 17 years of age (mean 11.1 years) were reviewed. Leg length discrepancy and muscle atrophy were the most common findings (five patients), with two patients also showing modelling deformity of the fibula. One patient with lower extremity involvement showed abnormal bone marrow signals on MR. Disabling joint contracture requiring orthopedic intervention was noted in one patient. In two patients with ''en coup de sabre'' facial deformity, CT and MR scans revealed intracranial calcifications and white matter abnormality in the ipsilateral frontal lobes, with one also showing migrational abnormality. In a third patient, CT revealed white matter abnormality in the ipsilateral parietal lobe. In one patient with progressive facial hemiatrophy, CT and MR scans showed the underlying hypoplastic left maxillary antrum and cheek. Imaging studies of areas of clinical concern revealed positive findings in half our patients. (orig.)

  7. Localized scleroderma: imaging features

    Energy Technology Data Exchange (ETDEWEB)

    Liu, P. (Dept. of Diagnostic Imaging, Hospital for Sick Children, Toronto, ON (Canada)); Uziel, Y. (Div. of Rheumatology, Hospital for Sick Children, Toronto, ON (Canada)); Chuang, S. (Dept. of Diagnostic Imaging, Hospital for Sick Children, Toronto, ON (Canada)); Silverman, E. (Div. of Rheumatology, Hospital for Sick Children, Toronto, ON (Canada)); Krafchik, B. (Div. of Dermatology, Dept. of Pediatrics, Hospital for Sick Children, Toronto, ON (Canada)); Laxer, R. (Div. of Rheumatology, Hospital for Sick Children, Toronto, ON (Canada))

    1994-06-01

    Localized scleroderma is distinct from the diffuse form of scleroderma and does not show Raynaud's phenomenon and visceral involvement. The imaging features in 23 patients ranging from 2 to 17 years of age (mean 11.1 years) were reviewed. Leg length discrepancy and muscle atrophy were the most common findings (five patients), with two patients also showing modelling deformity of the fibula. One patient with lower extremity involvement showed abnormal bone marrow signals on MR. Disabling joint contracture requiring orthopedic intervention was noted in one patient. In two patients with ''en coup de sabre'' facial deformity, CT and MR scans revealed intracranial calcifications and white matter abnormality in the ipsilateral frontal lobes, with one also showing migrational abnormality. In a third patient, CT revealed white matter abnormality in the ipsilateral parietal lobe. In one patient with progressive facial hemiatrophy, CT and MR scans showed the underlying hypoplastic left maxillary antrum and cheek. Imaging studies of areas of clinical concern revealed positive findings in half our patients. (orig.)

  8. Aplastic anemia: clinico haematological features, treatment and outcome analysis

    International Nuclear Information System (INIS)

    Wali, R.; Fadoo, Z.; Naqvi, M.A.

    2011-01-01

    To determine the clinico haematological features, treatment and outcome of children diagnosed with aplastic anemia at a single institution. Study Design: Observational study. Place and Duration of Study: The Aga Khan University Hospital, Karachi, from January 1999 till December 2008. Methodology: Medical records of children aged less than 15 years of age diagnosed with aplastic anemia were reviewed. Clinico haematological features, treatment and its response to therapy and outcome were recorded. Results were described in percentages. Results: Ninety patients were diagnosed to have aplastic anemia (AA); 65 were male during the study period. Age ranged from 1 to 15 years. Fever in 65 patients (72.2%), pallor in 53 (58.8%), skin bleeding in 49 (54.4%) and epistaxis in 31(34.4%) were the most common and frequent presenting features. Congenital (Fanconi's) anemia was found in 15 (16.6%) and acquired idiopathic in 75 (83.4%) of patients. Very severe aplastic anemia (VSAA) was seen in 29 (32.2%), 26 (28.9%) had severe AA and 17 (18.9%) had moderate AA. Eight patients (8.9%) underwent haematopoietic stem cell transplantation (HSCT), 12 (13.3%) received immunosuppressive therapy (IST) and 70 patients (77.7%) received other and supportive therapy. Five (62.5%) patients showed complete response to HSCT and 3 (37.5%) failed to engraft. IST showed complete response in 3 (25%), partial response in 5 (41.6%) and no response in 4 (33.3%). Twenty two patients (24.4%) expired either due to infection in 16 (72.7%, fungal in 6, bacterial in 10) and intracranial haemorrhage in 6 (27.3%) cases. Conclusion: Majority of cases with AA were acquired and idiopathic in etiology. VSAA and SAA were frequent. Response to HSCT and IST was sub-optimal. (author)

  9. Novel methodology for pharmaceutical expenditure forecast

    OpenAIRE

    Vataire, Anne-Lise; Cetinsoy, Laurent; Aball?a, Samuel; R?muzat, C?cile; Urbinati, Duccio; Kornfeld, ?sa; Mzoughi, Olfa; Toumi, Mondher

    2014-01-01

    Background and objective: The value appreciation of new drugs across countries today features a disruption that is making the historical data that are used for forecasting pharmaceutical expenditure poorly reliable. Forecasting methods rarely addressed uncertainty. The objective of this project was to propose a methodology to perform pharmaceutical expenditure forecasting that integrates expected policy changes and uncertainty (developed for the European Commission as the ‘EU Pharmaceutical e...

  10. Framework of Comprehensive Proliferation Resistance Evaluation Methodology

    International Nuclear Information System (INIS)

    Kim, Min Su; Jo, Seong Youn; Kim, Min Soo; Kim, Jae San; Lee, Hyun Kyung

    2007-01-01

    Civilian nuclear programs can be used as a pretext to acquire technologies, materials, equipment for military weapon programs. Consequently, international society has a strong incentive to develop a nuclear system more proliferation resistant to assure that the civilian nuclear energy system is an unattractive and least desirable route for diversion of weapon usable material. The First step developing a more proliferation resistant nuclear energy system is to develop a systematic and standardized evaluation methodology to ensure that any future nuclear energy system satisfies the proliferation resistance goals. Many attempts to develop systematic evaluation methodology have been proposed and many systems for assessing proliferation resistance have been previously studied. However, a comprehensive proliferation resistance evaluation can not be achieved by simply applying one method since complicated proliferation resistance characteristics, including inherent features and extrinsic features, should be completely evaluated. Therefore, it is necessary to develop one incorporated evaluation methodology to make up for weak points of each evaluation method. The objective of this study is to provide a framework of comprehensive proliferation resistance evaluation methodology by incorporating two generally used evaluation methods, attribute and scenario analysis

  11. Examining emotional expressions in discourse: methodological considerations

    Science.gov (United States)

    Hufnagel, Elizabeth; Kelly, Gregory J.

    2017-10-01

    This methodological paper presents an approach for examining emotional expressions through discourse analysis and ethnographic methods. Drawing on trends in the current literature in science education, we briefly explain the importance of emotions in science education and examine the current research methodologies used in interactional emotion studies. We put forth and substantiate a methodological approach that attends to the interactional, contextual, intertextual, and consequential aspects of emotional expressions. By examining emotional expressions in the discourse in which they are constructed, emotional expressions are identified through semantics, contextualization, and linguistic features. These features make salient four dimensions of emotional expressions: aboutness, frequency, type, and ownership. Drawing on data from a large empirical study of pre-service elementary teachers' emotional expressions about climate change in a science course, we provide illustrative examples to describe what counts as emotional expressions in situ. In doing so we explain how our approach makes salient the nuanced nature of such expressions as well as the broader discourse in which they are constructed and the implications for researching emotional expressions in science education discourse. We suggest reasons why this discourse orientated research methodology can contribute to the interactional study of emotions in science education contexts.

  12. Computer Network Operations Methodology

    Science.gov (United States)

    2004-03-01

    means of their computer information systems. Disrupt - This type of attack focuses on disrupting as “attackers might surreptitiously reprogram enemy...by reprogramming the computers that control distribution within the power grid. A disruption attack introduces disorder and inhibits the effective...between commanders. The use of methodologies is widespread and done subconsciously to assist individuals in decision making. The processes that

  13. SCI Hazard Report Methodology

    Science.gov (United States)

    Mitchell, Michael S.

    2010-01-01

    This slide presentation reviews the methodology in creating a Source Control Item (SCI) Hazard Report (HR). The SCI HR provides a system safety risk assessment for the following Ares I Upper Stage Production Contract (USPC) components (1) Pyro Separation Systems (2) Main Propulsion System (3) Reaction and Roll Control Systems (4) Thrust Vector Control System and (5) Ullage Settling Motor System components.

  14. A Functional HAZOP Methodology

    DEFF Research Database (Denmark)

    Liin, Netta; Lind, Morten; Jensen, Niels

    2010-01-01

    A HAZOP methodology is presented where a functional plant model assists in a goal oriented decomposition of the plant purpose into the means of achieving the purpose. This approach leads to nodes with simple functions from which the selection of process and deviation variables follow directly...

  15. Complicating Methodological Transparency

    Science.gov (United States)

    Bridges-Rhoads, Sarah; Van Cleave, Jessica; Hughes, Hilary E.

    2016-01-01

    A historical indicator of the quality, validity, and rigor of qualitative research has been the documentation and disclosure of the behind-the-scenes work of the researcher. In this paper, we use what we call "methodological data" as a tool to complicate the possibility and desirability of such transparency. Specifically, we draw on our…

  16. Methodological Advances in Dea

    NARCIS (Netherlands)

    L. Cherchye (Laurens); G.T. Post (Thierry)

    2001-01-01

    textabstractWe survey the methodological advances in DEA over the last 25 years and discuss the necessary conditions for a sound empirical application. We hope this survey will contribute to the further dissemination of DEA, the knowledge of its relative strengths and weaknesses, and the tools

  17. NUSAM Methodology for Assessment.

    Energy Technology Data Exchange (ETDEWEB)

    Leach, Janice [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Snell, Mark K. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-07-01

    This document provides a methodology for the performance-based assessment of security systems designed for the protection of nuclear and radiological materials and the processes that produce and/or involve them. It is intended for use with both relatively simple installations and with highly regulated complex sites with demanding security requirements.

  18. MIRD methodology. Part 1

    International Nuclear Information System (INIS)

    Rojo, Ana M.

    2004-01-01

    This lecture develops the MIRD (Medical Internal Radiation Dose) methodology for the evaluation of the internal dose due to the administration of radiopharmaceuticals. In this first part, the basic concepts and the main equations are presented. The ICRP Dosimetric System is also explained. (author)

  19. Response Surface Methodology

    NARCIS (Netherlands)

    Kleijnen, Jack P.C.

    2014-01-01

    Abstract: This chapter first summarizes Response Surface Methodology (RSM), which started with Box and Wilson’s article in 1951 on RSM for real, non-simulated systems. RSM is a stepwise heuristic that uses first-order polynomials to approximate the response surface locally. An estimated polynomial

  20. MIRD methodology. Part 2

    International Nuclear Information System (INIS)

    Gomez Parada, Ines

    2004-01-01

    This paper develops the MIRD (Medical Internal Radiation Dose) methodology for the evaluation of the internal dose due to the administration of radiopharmaceuticals. In this second part, different methods for the calculation of the accumulated activity are presented, together with the effective half life definition. Different forms of Retention Activity curves are also shown. (author)

  1. Interactive music composition driven by feature evolution.

    Science.gov (United States)

    Kaliakatsos-Papakostas, Maximos A; Floros, Andreas; Vrahatis, Michael N

    2016-01-01

    Evolutionary music composition is a prominent technique for automatic music generation. The immense adaptation potential of evolutionary algorithms has allowed the realisation of systems that automatically produce music through feature and interactive-based composition approaches. Feature-based composition employs qualitatively descriptive music features as fitness landmarks. Interactive composition systems on the other hand, derive fitness directly from human ratings and/or selection. The paper at hand introduces a methodological framework that combines the merits of both evolutionary composition methodologies. To this end, a system is presented that is organised in two levels: the higher level of interaction and the lower level of composition. The higher level incorporates the particle swarm optimisation algorithm, along with a proposed variant and evolves musical features according to user ratings. The lower level realizes feature-based music composition with a genetic algorithm, according to the top level features. The aim of this work is not to validate the efficiency of the currently utilised setup in each level, but to examine the convergence behaviour of such a two-level technique in an objective manner. Therefore, an additional novelty in this work concerns the utilisation of artificial raters that guide the system through the space of musical features, allowing the exploration of its convergence characteristics: does the system converge to optimal melodies, is this convergence fast enough for potential human listeners and is the trajectory to convergence "interesting' and "creative" enough? The experimental results reveal that the proposed methodological framework represents a fruitful and robust, novel approach to interactive music composition.

  2. Reference Performance Test Methodology for Degradation Assessment of Lithium-Sulfur Batteries

    DEFF Research Database (Denmark)

    Knap, Vaclav; Stroe, Daniel-Ioan; Purkayastha, Rajlakshmi

    2018-01-01

    Lithium-Sulfur (Li-S) is an emerging battery technology receiving a growing amount of attention due to its potentially high gravimetric energy density, safety, and low production cost. However, there are still some obstacles preventing its swift commercialization. Li-S batteries are driven...... by different electrochemical processes than commonly used Lithium-ion batteries, which often results in very different behavior. Therefore, the testing and modeling of these systems have to be adjusted to reflect their unique behavior and to prevent possible bias. A methodology for a Reference Performance Test...... (RPT) for the Li-S batteries is proposed in this study to point out Li-S battery features and provide guidance to users how to deal with them and possible results into standardization. The proposed test methodology is demonstrated for 3.4 Ah Li-S cells aged under different conditions....

  3. Soft Systems Methodology

    Science.gov (United States)

    Checkland, Peter; Poulter, John

    Soft systems methodology (SSM) is an approach for tackling problematical, messy situations of all kinds. It is an action-oriented process of inquiry into problematic situations in which users learn their way from finding out about the situation, to taking action to improve it. The learning emerges via an organised process in which the situation is explored using a set of models of purposeful action (each built to encapsulate a single worldview) as intellectual devices, or tools, to inform and structure discussion about a situation and how it might be improved. This paper, written by the original developer Peter Checkland and practitioner John Poulter, gives a clear and concise account of the approach that covers SSM's specific techniques, the learning cycle process of the methodology and the craft skills which practitioners develop. This concise but theoretically robust account nevertheless includes the fundamental concepts, techniques, core tenets described through a wide range of settings.

  4. Transparent Guideline Methodology Needed

    DEFF Research Database (Denmark)

    Lidal, Ingeborg; Norén, Camilla; Mäkelä, Marjukka

    2013-01-01

    As part of learning at the Nordic Workshop of Evidence-based Medicine, we have read with interest the practice guidelines for central venous access, published in your Journal in 2012.1 We appraised the quality of this guideline using the checklist developed by The Evidence-Based Medicine Working ...... are based on best currently available evidence. Our concerns are in two main categories: the rigor of development, including methodology of searching, evaluating, and combining the evidence; and editorial independence, including funding and possible conflicts of interest....... Group.2 Similar criteria for guideline quality have been suggested elsewhere.3 Our conclusion was that this much needed guideline is currently unclear about several aspects of the methodology used in developing the recommendations. This means potential users cannot be certain that the recommendations...

  5. Web survey methodology

    CERN Document Server

    Callegaro, Mario; Vehovar, Asja

    2015-01-01

    Web Survey Methodology guides the reader through the past fifteen years of research in web survey methodology. It both provides practical guidance on the latest techniques for collecting valid and reliable data and offers a comprehensive overview of research issues. Core topics from preparation to questionnaire design, recruitment testing to analysis and survey software are all covered in a systematic and insightful way. The reader will be exposed to key concepts and key findings in the literature, covering measurement, non-response, adjustments, paradata, and cost issues. The book also discusses the hottest research topics in survey research today, such as internet panels, virtual interviewing, mobile surveys and the integration with passive measurements, e-social sciences, mixed modes and business intelligence. The book is intended for students, practitioners, and researchers in fields such as survey and market research, psychological research, official statistics and customer satisfaction research.

  6. Steganography: LSB Methodology

    Science.gov (United States)

    2012-08-02

    of LSB steganography in grayscale and color images . In J. Dittmann, K. Nahrstedt, and P. Wohlmacher, editors, Proceedings of the ACM, Special...Fridrich, M. Gojan and R. Du paper titled “Reliable detection of LSB steganography in grayscale and color images ”. From a general perspective Figure 2...REPORT Steganography : LSB Methodology (Progress Report) 14. ABSTRACT 16. SECURITY CLASSIFICATION OF: In computer science, steganography is the science

  7. Butterfly valve torque prediction methodology

    International Nuclear Information System (INIS)

    Eldiwany, B.H.; Sharma, V.; Kalsi, M.S.; Wolfe, K.

    1994-01-01

    As part of the Motor-Operated Valve (MOV) Performance Prediction Program, the Electric Power Research Institute has sponsored the development of methodologies for predicting thrust and torque requirements of gate, globe, and butterfly MOVs. This paper presents the methodology that will be used by utilities to calculate the dynamic torque requirements for butterfly valves. The total dynamic torque at any disc position is the sum of the hydrodynamic torque, bearing torque (which is induced by the hydrodynamic force), as well as other small torque components (such as packing torque). The hydrodynamic torque on the valve disc, caused by the fluid flow through the valve, depends on the disc angle, flow velocity, upstream flow disturbances, disc shape, and the disc aspect ratio. The butterfly valve model provides sets of nondimensional flow and torque coefficients that can be used to predict flow rate and hydrodynamic torque throughout the disc stroke and to calculate the required actuation torque and the maximum transmitted torque throughout the opening and closing stroke. The scope of the model includes symmetric and nonsymmetric discs of different shapes and aspects ratios in compressible and incompressible fluid applications under both choked and nonchoked flow conditions. The model features were validated against test data from a comprehensive flowloop and in situ test program. These tests were designed to systematically address the effect of the following parameters on the required torque: valve size, disc shapes and disc aspect ratios, upstream elbow orientation and its proximity, and flow conditions. The applicability of the nondimensional coefficients to valves of different sizes was validated by performing tests on 42-in. valve and a precisely scaled 6-in. model. The butterfly valve model torque predictions were found to bound test data from the flow-loop and in situ testing, as shown in the examples provided in this paper

  8. System Anthropological Psychology: Methodological Foundations

    Directory of Open Access Journals (Sweden)

    Vitaliy Y. Klochko

    2012-01-01

    Full Text Available The article considers methodological foundations of the system anthropologicalpsychology (SAP as a scientific branch developed by a well-represented groupof Siberian scientists. SAP is a theory based on axiomatics of cultural-historicalpsychology of L.S. Vygotsky and transspective analysis as a specially developedmeans to define the tendencies of science developing as a self-organizing system.Transspective analysis has revealed regularities in a constantly growing complexityof professional-psychological thinking along the course of emergence ofscientific cognition. It has proved that the field of modern psychology is shapedby theories constructed with ideation of different grades of complexity. The concept“dynamics of the paradigm of science” is introduced; it allows transitions tobe acknowledged from ordinary-binary logic characteristics of the classical scienceto a binary-ternary logic, adequate to non-classical science and then to aternary-multidimensional logic, which is now at the stage of emergence. The latteris employed in SAP construction. It involves the following basic methodologicalprinciples: the principle of directed (selective interaction and the principle ofgenerative effect of selective interaction. The concept of “complimentary interaction”applied in natural as well as humanitarian sciences is reconsidered in thecontext of psychology. The conclusion is made that the principle of selectivity anddirectedness of interaction is relevant to the whole Universe embracing all kindsof systems including the living ones. Different levels of matter organization representingsemantic structures of various complexity use one and the same principleof meaning making through which the Universe ensures its sustainability asa self-developing phenomenon. This methodology provides an explanation fornature and stages of emergence of multidimensional life space of an individual,which comes as a foundation for generation of such features of

  9. Soil Radiological Characterisation Methodology

    International Nuclear Information System (INIS)

    Attiogbe, Julien; Aubonnet, Emilie; De Maquille, Laurence; De Moura, Patrick; Desnoyers, Yvon; Dubot, Didier; Feret, Bruno; Fichet, Pascal; Granier, Guy; Iooss, Bertrand; Nokhamzon, Jean-Guy; Ollivier Dehaye, Catherine; Pillette-Cousin, Lucien; Savary, Alain

    2014-12-01

    This report presents the general methodology and best practice approaches which combine proven existing techniques for sampling and characterisation to assess the contamination of soils prior to remediation. It is based on feedback of projects conducted by main French nuclear stakeholders involved in the field of remediation and dismantling (EDF, CEA, AREVA and IRSN). The application of this methodology will enable the project managers to obtain the elements necessary for the drawing up of files associated with remediation operations, as required by the regulatory authorities. It is applicable to each of the steps necessary for the piloting of remediation work-sites, depending on the objectives targeted (release into the public domain, re-use, etc.). The main part describes the applied statistical methodology with the exploratory analysis and variogram data, identification of singular points and their location. The results obtained permit assessment of a mapping to identify the contaminated surface and subsurface areas. It stakes the way for radiological site characterisation since the initial investigations from historical and functional analysis to check that the remediation objectives have been met. It follows an example application from the feedback of the remediation of a contaminated site on the Fontenay aux Roses facility. It is supplemented by a glossary of main terms used in the field from different publications or international standards. This technical report is a support of the ISO Standard ISO ISO/TC 85/SC 5 N 18557 'Sampling and characterisation principles for soils, buildings and infrastructures contaminated by radionuclides for remediation purposes'. (authors) [fr

  10. A bank-fund projection framework with CGE features

    DEFF Research Database (Denmark)

    Jensen, Henning Tarp; Tarp, Finn

    2006-01-01

    In this paper, we present a SAM-based methodology for integrating standard CGE features with a macroeconomic World Bank–International Monetary Fund (IMF) modelling framework. The resulting macro–micro framework is based on optimising agents, but it retains key features from the macroeconomic model...

  11. A Standard Bank-Fund Projection Framework with CGE Features

    DEFF Research Database (Denmark)

    Jensen, Henning Tarp; Tarp, Finn

    2006-01-01

    In this paper, we present a SAM-based methodology for integrating standard CGE features with a macroeconomic World Bank–International Monetary Fund (IMF) modelling framework. The resulting macro–micro framework is based on optimising agents, but it retains key features from the macroeconomic model...

  12. Level Sets and Voronoi based Feature Extraction from any Imagery

    DEFF Research Database (Denmark)

    Sharma, O.; Anton, François; Mioc, Darka

    2012-01-01

    Polygon features are of interest in many GEOProcessing applications like shoreline mapping, boundary delineation, change detection, etc. This paper presents a unique new GPU-based methodology to automate feature extraction combining level sets, or mean shift based segmentation together with Voron...

  13. Corporate governance and audit features: SMEs evidence

    OpenAIRE

    Al-Najjar, Basil

    2018-01-01

    Purpose\\ud The purpose of this paper is to investigate the effect of corporate governance factors on audit features, namely, audit fees and the selection of Big 4 audit firms within the UK SMEs context.\\ud \\ud Design/methodology/approach\\ud The author uses different regression models to investigate the impact of corporate governance characteristics on audit features, and employs cross-sectional time series models as well as two-stage least squares technique. In addition, the author has used l...

  14. Emotion and Aging: Evidence from Brain and Behavior

    Directory of Open Access Journals (Sweden)

    Natalie eEbner

    2014-09-01

    Full Text Available Emotions play a central role in every human life from the moment we are born until we die. They prepare the body for action, highlight what should be noticed and remembered, and guide decisions and actions. As emotions are central to daily functioning, it is important to understand how aging affects perception, memory, experience, as well as regulation of emotions. The Frontiers research topic Emotion and Aging: Evidence from Brain and Behavior takes a step into uncovering emotional aging considering both brain and behavioral processes. The contributions featured in this issue adopt innovative theoretical perspectives and use novel methodological approaches to target a variety of topics that can be categorized into three overarching questions: How do cognition and emotion interact in aging in brain and behavior? What are behavioral and brain-related moderators of emotional aging? Does emotion-regulatory success as reflected in brain and behavior change with age? In this perspective paper we discuss theoretical innovation, methodological approach, and scientific advancement of the thirteen papers in the context of the broader literature on emotional aging. We conclude by reflecting on topics untouched and future directions to take.

  15. Imaging features of kaposiform lymphangiomatosis

    International Nuclear Information System (INIS)

    Goyal, Pradeep; Alomari, Ahmad I.; Shaikh, Raja; Chaudry, Gulraiz; Kozakewich, Harry P.; Perez-Atayde, Antonio R.; Trenor, Cameron C.; Fishman, Steven J.; Greene, Arin K.

    2016-01-01

    Kaposiform lymphangiomatosis is a rare, aggressive lymphatic disorder. The imaging and presenting features of kaposiform lymphangiomatosis can overlap with those of central conducting lymphatic anomaly and generalized lymphatic anomaly. To analyze the imaging findings of kaposiform lymphangiomatosis disorder and highlight features most suggestive of this diagnosis. We retrospectively identified and characterized 20 children and young adults with histopathological diagnosis of kaposiform lymphangiomatosis and radiologic imaging referred to the vascular anomalies center between 1995 and 2015. The median age at onset was 6.5 years (range 3 months to 27 years). The most common presenting features were respiratory compromise (dyspnea, cough, chest pain; 55.5%), swelling/mass (25%), bleeding (15%) and fracture (5%). The thoracic cavity was involved in all patients; all patients had mediastinal involvement followed by lung parenchymal disease (90%) and pleural (85%) and pericardial (50%) effusions. The most common extra-thoracic sites of disease were the retroperitoneum (80%), bone (60%), abdominal viscera (55%) and muscles (45%). There was characteristic enhancing and infiltrative soft-tissue thickening in the mediastinum and retroperitoneum extending along the lymphatic distribution. Kaposiform lymphangiomatosis has overlapping imaging features with central conducting lymphatic anomaly and generalized lymphatic anomaly. Presence of mediastinal or retroperitoneal enhancing and infiltrative soft-tissue disease along the lymphatic distribution, hemorrhagic effusions and moderate thrombocytopenia (50-100,000/μl) should favor diagnosis of kaposiform lymphangiomatosis. (orig.)

  16. Methodology applied to develop the DHIE: applied methodology

    CSIR Research Space (South Africa)

    Herselman, Marlien

    2016-12-01

    Full Text Available This section will address the methodology that was applied to develop the South African Digital Health Innovation Ecosystem (DHIE). Each chapter under Section B represents a specific phase in the methodology....

  17. Volcanic features of Io

    International Nuclear Information System (INIS)

    Carr, M.H.; Masursky, H.; Strom, R.G.; Terrile, R.J.

    1979-01-01

    The volcanic features of Io as detected during the Voyager mission are discussed. The volcanic activity is apparently higher than on any other body in the Solar System. Its volcanic landforms are compared with features on Earth to indicate the type of volcanism present on Io. (U.K.)

  18. Core analysis: new features and applications

    International Nuclear Information System (INIS)

    Edenius, M.; Kurcyusz, E.; Molina, D.; Wiksell, G.

    1995-01-01

    Today, core analysis may be performed with sophisticated software capable of both steady state and transient analysis using a common methodology for BWRs and PWRs. General trends in core analysis software development are: improved accuracy, automated engineering functions; three-dimensional transient capability; graphical user interfaces. As a demonstration of such software, new features of Studsvik-CMS (Core management system) and examples of applications are discussed in this article. 2 figs., 8 refs

  19. Case Study Research Methodology

    Directory of Open Access Journals (Sweden)

    Mark Widdowson

    2011-01-01

    Full Text Available Commenting on the lack of case studies published in modern psychotherapy publications, the author reviews the strengths of case study methodology and responds to common criticisms, before providing a summary of types of case studies including clinical, experimental and naturalistic. Suggestions are included for developing systematic case studies and brief descriptions are given of a range of research resources relating to outcome and process measures. Examples of a pragmatic case study design and a hermeneutic single-case efficacy design are given and the paper concludes with some ethical considerations and an exhortation to the TA community to engage more widely in case study research.

  20. Sample size methodology

    CERN Document Server

    Desu, M M

    2012-01-01

    One of the most important problems in designing an experiment or a survey is sample size determination and this book presents the currently available methodology. It includes both random sampling from standard probability distributions and from finite populations. Also discussed is sample size determination for estimating parameters in a Bayesian setting by considering the posterior distribution of the parameter and specifying the necessary requirements. The determination of the sample size is considered for ranking and selection problems as well as for the design of clinical trials. Appropria

  1. Geotechnical site assessment methodology

    International Nuclear Information System (INIS)

    Tunbridge, L.W.; Richards, L.R.

    1985-09-01

    The reports comprising this volume concern the research conducted on geotechnical site assessment methodology at the Carwynnen test mine in granites in Cornwall, with particular reference to the effect of structures imposed by discontinuities on the engineering behaviour of rock masses. The topics covered are: in-situ stress measurements using (a) the hydraulic fracturing method, or (b) the US Bureau of Mines deformation probe; scanline discontinuity survey - coding form and instructions, and data; applicability of geostatistical estimation methods to scalar rock properties; comments on in-situ stress at the Carwynnen test mine and the state of stress in the British Isles. (U.K.)

  2. MIRD methodology; Metodologia MIRD

    Energy Technology Data Exchange (ETDEWEB)

    Rojo, Ana M [Autoridad Regulatoria Nuclear, Buenos Aires (Argentina); Gomez Parada, Ines [Sociedad Argentina de Radioproteccion, Buenos Aires (Argentina)

    2004-07-01

    The MIRD (Medical Internal Radiation Dose) system was established by the Society of Nuclear Medicine of USA in 1960 to assist the medical community in the estimation of the dose in organs and tissues due to the incorporation of radioactive materials. Since then, 'MIRD Dose Estimate Report' (from the 1 to 12) and 'Pamphlets', of great utility for the dose calculations, were published. The MIRD system was planned essentially for the calculation of doses received by the patients during nuclear medicine diagnostic procedures. The MIRD methodology for the absorbed doses calculations in different tissues is explained.

  3. Beam optimization: improving methodology

    International Nuclear Information System (INIS)

    Quinteiro, Guillermo F.

    2004-01-01

    Different optimization techniques commonly used in biology and food technology allow a systematic and complete analysis of response functions. In spite of the great interest in medical and nuclear physics in the problem of optimizing mixed beams, little attention has been given to sophisticate mathematical tools. Indeed, many techniques are perfectly suited to the typical problem of beam optimization. This article is intended as a guide to the use of two methods, namely Response Surface Methodology and Simplex, that are expected to fasten the optimization process and, meanwhile give more insight into the relationships among the dependent variables controlling the response

  4. Literacy research methodologies

    CERN Document Server

    Duke, Nell K

    2012-01-01

    The definitive reference on literacy research methods, this book serves as a key resource for researchers and as a text in graduate-level courses. Distinguished scholars clearly describe established and emerging methodologies, discuss the types of questions and claims for which each is best suited, identify standards of quality, and present exemplary studies that illustrate the approaches at their best. The book demonstrates how each mode of inquiry can yield unique insights into literacy learning and teaching and how the methods can work together to move the field forward.   New to This Editi

  5. Methodology of site studies

    International Nuclear Information System (INIS)

    Caries, J.C.; Hugon, J.; Grauby, A.

    1980-01-01

    This methodology consists in an essentially dynamic, estimated and follow-up analysis of the impact of discharges on all the environment compartments, whether natural or not, that play a part in the protection of man and his environment. It applies at two levels, to wit: the choice of site, or the detailed study of the site selected. Two examples of its application will be developed, namely: at the choice of site level in the case of marine sites, and of the detailed study level of the chosen site in that of a riverside site [fr

  6. Alternative pricing methodologies

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    With the increased interest in competitive market forces and growing recognition of the deficiencies in current practices, FERC and others are exploring alternatives to embedded cost pricing. A number of these alternatives are discussed in this chapter. Marketplace pricing, discussed briefly here, is the subject of the next chapter. Obviously, the pricing formula may combine several of these methodologies. One utility of which the authors are aware is seeking a price equal to the sum of embedded costs, opportunity costs, line losses, value of service, FERC's percentage adder formula and a contract service charge

  7. JCE Feature Columns

    Science.gov (United States)

    Holmes, Jon L.

    1999-05-01

    The Features area of JCE Online is now readily accessible through a single click from our home page. In the Features area each column is linked to its own home page. These column home pages also have links to them from the online Journal Table of Contents pages or from any article published as part of that feature column. Using these links you can easily find abstracts of additional articles that are related by topic. Of course, JCE Online+ subscribers are then just one click away from the entire article. Finding related articles is easy because each feature column "site" contains links to the online abstracts of all the articles that have appeared in the column. In addition, you can find the mission statement for the column and the email link to the column editor that I mentioned above. At the discretion of its editor, a feature column site may contain additional resources. As an example, the Chemical Information Instructor column edited by Arleen Somerville will have a periodically updated bibliography of resources for teaching and using chemical information. Due to the increase in the number of these resources available on the WWW, it only makes sense to publish this information online so that you can get to these resources with a simple click of the mouse. We expect that there will soon be additional information and resources at several other feature column sites. Following in the footsteps of the Chemical Information Instructor, up-to-date bibliographies and links to related online resources can be made available. We hope to extend the online component of our feature columns with moderated online discussion forums. If you have a suggestion for an online resource you would like to see included, let the feature editor or JCE Online (jceonline@chem.wisc.edu) know about it. JCE Internet Features JCE Internet also has several feature columns: Chemical Education Resource Shelf, Conceptual Questions and Challenge Problems, Equipment Buyers Guide, Hal's Picks, Mathcad

  8. Methodology for plastic fracture - a progress report

    International Nuclear Information System (INIS)

    Wilkinson, J.P.D.; Smith, R.E.E.

    1977-01-01

    This paper describes the progress of a study to develop a methodology for plastic fracture. Such a fracture mechanics methodology, having application in the plastic region, is required to assess the margin of safety inherent in nuclear reactor pressure vessels. The initiation and growth of flaws in pressure vessels under overload conditions is distinguished by a number of unique features, such as large scale yielding, three-dimensional structural and flaw configurations, and failure instabilities that may be controlled by either toughness or plastic flow. In order to develop a broadly applicable methodology of plastic fracture, these features require the following analytical and experimental studies: development of criteria for crack initiation and growth under large scale yielding; the use of the finite element method to describe elastic-plastic behaviour of both the structure and the crack tip region; and extensive experimental studies on laboratory scale and large scale specimens, which attempt to reproduce the pertinent plastic flow and crack growth phenomena. This discussion centers on progress to date on the selection, through analysis and laboratory experiments, of viable criteria for crack initiation and growth during plastic fracture. (Auth.)

  9. Waste Package Design Methodology Report

    Energy Technology Data Exchange (ETDEWEB)

    D.A. Brownson

    2001-09-28

    The objective of this report is to describe the analytical methods and processes used by the Waste Package Design Section to establish the integrity of the various waste package designs, the emplacement pallet, and the drip shield. The scope of this report shall be the methodology used in criticality, risk-informed, shielding, source term, structural, and thermal analyses. The basic features and appropriateness of the methods are illustrated, and the processes are defined whereby input values and assumptions flow through the application of those methods to obtain designs that ensure defense-in-depth as well as satisfy requirements on system performance. Such requirements include those imposed by federal regulation, from both the U.S. Department of Energy (DOE) and U.S. Nuclear Regulatory Commission (NRC), and those imposed by the Yucca Mountain Project to meet repository performance goals. The report is to be used, in part, to describe the waste package design methods and techniques to be used for producing input to the License Application Report.

  10. Waste Package Design Methodology Report

    International Nuclear Information System (INIS)

    D.A. Brownson

    2001-01-01

    The objective of this report is to describe the analytical methods and processes used by the Waste Package Design Section to establish the integrity of the various waste package designs, the emplacement pallet, and the drip shield. The scope of this report shall be the methodology used in criticality, risk-informed, shielding, source term, structural, and thermal analyses. The basic features and appropriateness of the methods are illustrated, and the processes are defined whereby input values and assumptions flow through the application of those methods to obtain designs that ensure defense-in-depth as well as satisfy requirements on system performance. Such requirements include those imposed by federal regulation, from both the U.S. Department of Energy (DOE) and U.S. Nuclear Regulatory Commission (NRC), and those imposed by the Yucca Mountain Project to meet repository performance goals. The report is to be used, in part, to describe the waste package design methods and techniques to be used for producing input to the License Application Report

  11. An Innovative Fuzzy-Logic-Based Methodology for Trend Identification

    International Nuclear Information System (INIS)

    Wang Xin; Tsoukalas, Lefteri H.; Wei, Thomas Y.C.; Reifman, Jaques

    2001-01-01

    A new fuzzy-logic-based methodology for on-line signal trend identification is introduced. The methodology may be used for detecting the onset of nuclear power plant (NPP) transients at the earliest possible time and could be of great benefit to diagnostic, maintenance, and performance-monitoring programs. Although signal trend identification is complicated by the presence of noise, fuzzy methods can help capture important features of on-line signals, integrate the information included in these features, and classify incoming NPP signals into increasing, decreasing, and steady-state trend categories. A computer program named PROTREN is developed and tested for the purpose of verifying this methodology using NPP and simulation data. The results indicate that the new fuzzy-logic-based methodology is capable of detecting transients accurately, it identifies trends reliably and does not misinterpret a steady-state signal as a transient one

  12. Bridging Minds: A Mixed Methodology to Assess Networked Flow.

    Science.gov (United States)

    Galimberti, Carlo; Chirico, Alice; Brivio, Eleonora; Mazzoni, Elvis; Riva, Giuseppe; Milani, Luca; Gaggioli, Andrea

    2015-01-01

    The main goal of this contribution is to present a methodological framework to study Networked Flow, a bio-psycho-social theory of collective creativity applying it on creative processes occurring via a computer network. First, we draw on the definition of Networked Flow to identify the key methodological requirements of this model. Next, we present the rationale of a mixed methodology, which aims at combining qualitative, quantitative and structural analysis of group dynamics to obtain a rich longitudinal dataset. We argue that this integrated strategy holds potential for describing the complex dynamics of creative collaboration, by linking the experiential features of collaborative experience (flow, social presence), with the structural features of collaboration dynamics (network indexes) and the collaboration outcome (the creative product). Finally, we report on our experience with using this methodology in blended collaboration settings (including both face-to-face and virtual meetings), to identify open issues and provide future research directions.

  13. AVISE, ageing anticipation methodology using expert judgement and stimulation. Application to a nuclear power plant component: the pressurizer; AVISE, Anticipation du Vieillissement par Interrogation et Stimulation d'Experts. Application a un materiel passif d'une centrale nucleaire: le pressuriseur

    Energy Technology Data Exchange (ETDEWEB)

    Bouzaiene-Marle, L

    2005-04-15

    This thesis deals with components ageing anticipation in the context of life cycle management. The proposed approach, called AVISE, allows the identification of potentials problems related to ageing, to measure the risks in terms of degradation probability and degradation consequences and gives the adequate solutions to stop or to postpone ageing. This research was undertaken in a particular industrial context, the nuclear industry. Equipments used in this context are specific and particularly reliable. These characteristics result in limited feedback (low number of failures). To compensate for this limited information, two solutions are proposed in this approach. The first solution that we can consider as a classical one consists in using expert judgement. The second one, more original, consists in using the operation feedback of 'similar' components. In order to apply these solutions and to obtain the anticipation results, a set of methodological tools was developed and tested in a real industrial application on a nuclear power plant component: the pressurizer. The first tool is a generic process for expert judgement, identified thanks to a comparison between eleven existing methods using expert judgement. Two methods based on expert stimulation and called STIMEX-IMDP and STIMEX-IPP were elaborated. A reference list of degradation mechanisms and a reference list of ageing effects were constructed and used in the method STIMEX-IMDP in order to help expert stimulation. Then, the developed approach proposes the use of belief networks to model and quantify the risks related to the potential degradations. Finally, the construction of a conceptual data model and specifications are given for the creation of an ageing database. The data to capitalize was identified on the basis of the research undertaken in this thesis. (author)

  14. AVISE, ageing anticipation methodology using expert judgement and stimulation. Application to a nuclear power plant component: the pressurizer; AVISE, Anticipation du Vieillissement par Interrogation et Stimulation d'Experts. Application a un materiel passif d'une centrale nucleaire: le pressuriseur

    Energy Technology Data Exchange (ETDEWEB)

    Bouzaiene-Marle, L

    2005-04-15

    This thesis deals with components ageing anticipation in the context of life cycle management. The proposed approach, called AVISE, allows the identification of potentials problems related to ageing, to measure the risks in terms of degradation probability and degradation consequences and gives the adequate solutions to stop or to postpone ageing. This research was undertaken in a particular industrial context, the nuclear industry. Equipments used in this context are specific and particularly reliable. These characteristics result in limited feedback (low number of failures). To compensate for this limited information, two solutions are proposed in this approach. The first solution that we can consider as a classical one consists in using expert judgement. The second one, more original, consists in using the operation feedback of 'similar' components. In order to apply these solutions and to obtain the anticipation results, a set of methodological tools was developed and tested in a real industrial application on a nuclear power plant component: the pressurizer. The first tool is a generic process for expert judgement, identified thanks to a comparison between eleven existing methods using expert judgement. Two methods based on expert stimulation and called STIMEX-IMDP and STIMEX-IPP were elaborated. A reference list of degradation mechanisms and a reference list of ageing effects were constructed and used in the method STIMEX-IMDP in order to help expert stimulation. Then, the developed approach proposes the use of belief networks to model and quantify the risks related to the potential degradations. Finally, the construction of a conceptual data model and specifications are given for the creation of an ageing database. The data to capitalize was identified on the basis of the research undertaken in this thesis. (author)

  15. Early experience with dual mobility acetabular systems featuring highly cross-linked polyethylene liners for primary hip arthroplasty in patients under fifty five years of age: an international multi-centre preliminary study.

    Science.gov (United States)

    Epinette, Jean-Alain; Harwin, Steven F; Rowan, Fiachra E; Tracol, Philippe; Mont, Michael A; Chughtai, Morad; Westrich, Geoffrey H

    2017-03-01

    To evaluate early performance of contemporary dual mobility acetabular systems with second generation annealed highly cross-linked polyethylene for primary hip arthroplasty of patients under 55 years of age. A prospective observational five years study across five centers in Europe and the USA of 321 patients with a mean age of 48.1 years was performed. Patients were assessed for causes of revision, hip instability, intra-prosthetic dissociation, Harris hip score and radiological signs of osteolysis. There were no dislocations and no intra-prosthetic dissociations. Kaplan Meier analysis demonstrated 97.51% survivorship for all cause revision and 99.68% survivorship for acetabular component revision at five years. Mean Harris hip score was 93.6. Two acetabular shells were revised for neck-rim implant impingement without dislocation and ten femoral stems were revised for causes unrelated to dual mobility implants. Contemporary highly cross-linked polyethylene dual mobility systems demonstrate excellent early clinical, radiological, and survivorship results in a cohort of patients that demand high performance from their implants. It is envisaged that DM and second generation annealed HXLPE may reduce THA instability and wear, the two most common causes of THA revision in hip arthroplasty.

  16. [The Ability to Successfully Perform Different Kinds of Cognitive Activity Is Reflected in the Topological Features of Intracortical Interactions (Sex Differences in Boys and Girls Aged 5-6 Years)].

    Science.gov (United States)

    Panasevich, E A; Tsitseroshin, M N

    2015-01-01

    We studied the correlation of intellectual development according to The Wechsler Intelligence Scale for Children (WISC test) with the spatial organization of resting EEG in 52 children aged 5-6 years. It was found that the patterns of interregional interactions of different parts of the cortex which correspond with the best performance in the subtests in boys (n = 23) and girls (n = 29) have significant topological differences. In girls, successful subtest performance positively correlated to a greater extent with interhemispheric interactions; in boys--long longitudinal rostral-caudal interactions between various regions of the cortex. The results showed that there are important gender differences in the spatial organization of brain activity associated with the performance of different cognitive activities in preschool children. The successful performance of various subtests by boys required considerable variability in the organization of spatial patterns of interregional interactions; on the contrary, the spatial structure of these patterns in girls was relatively invariable. Obviously, for the successful performance of various cognitive activities at this age in boys, the cortex need to form highly specialized organization of intracortical interactions, while in girls the brain uses relatively similar reorganization of interactions. The data suggest that 5-6-year-old boys and girls use different cognitive strategies when performing the same subtests of the WISC test.

  17. LOFT uncertainty-analysis methodology

    International Nuclear Information System (INIS)

    Lassahn, G.D.

    1983-01-01

    The methodology used for uncertainty analyses of measurements in the Loss-of-Fluid Test (LOFT) nuclear-reactor-safety research program is described and compared with other methodologies established for performing uncertainty analyses

  18. LOFT uncertainty-analysis methodology

    International Nuclear Information System (INIS)

    Lassahn, G.D.

    1983-01-01

    The methodology used for uncertainty analyses of measurements in the Loss-of-Fluid Test (LOFT) nuclear reactor safety research program is described and compared with other methodologies established for performing uncertainty analyses

  19. RHIC Data Correlation Methodology

    International Nuclear Information System (INIS)

    Michnoff, R.; D'Ottavio, T.; Hoff, L.; MacKay, W.; Satogata, T.

    1999-01-01

    A requirement for RHIC data plotting software and physics analysis is the correlation of data from all accelerator data gathering systems. Data correlation provides the capability for a user to request a plot of multiple data channels vs. time, and to make meaningful time-correlated data comparisons. The task of data correlation for RHIC requires careful consideration because data acquisition triggers are generated from various asynchronous sources including events from the RHIC Event Link, events from the two Beam Sync Links, and other unrelated clocks. In order to correlate data from asynchronous acquisition systems a common time reference is required. The RHIC data correlation methodology will allow all RHIC data to be converted to a common wall clock time, while still preserving native acquisition trigger information. A data correlation task force team, composed of the authors of this paper, has been formed to develop data correlation design details and provide guidelines for software developers. The overall data correlation methodology will be presented in this paper

  20. Intelligent systems engineering methodology

    Science.gov (United States)

    Fouse, Scott

    1990-01-01

    An added challenge for the designers of large scale systems such as Space Station Freedom is the appropriate incorporation of intelligent system technology (artificial intelligence, expert systems, knowledge-based systems, etc.) into their requirements and design. This presentation will describe a view of systems engineering which successfully addresses several aspects of this complex problem: design of large scale systems, design with requirements that are so complex they only completely unfold during the development of a baseline system and even then continue to evolve throughout the system's life cycle, design that involves the incorporation of new technologies, and design and development that takes place with many players in a distributed manner yet can be easily integrated to meet a single view of the requirements. The first generation of this methodology was developed and evolved jointly by ISX and the Lockheed Aeronautical Systems Company over the past five years on the Defense Advanced Research Projects Agency/Air Force Pilot's Associate Program, one of the largest, most complex, and most successful intelligent systems constructed to date. As the methodology has evolved it has also been applied successfully to a number of other projects. Some of the lessons learned from this experience may be applicable to Freedom.

  1. SMART performance analysis methodology

    International Nuclear Information System (INIS)

    Lim, H. S.; Kim, H. C.; Lee, D. J.

    2001-04-01

    To ensure the required and desired operation over the plant lifetime, the performance analysis for the SMART NSSS design is done by means of the specified analysis methodologies for the performance related design basis events(PRDBE). The PRDBE is an occurrence(event) that shall be accommodated in the design of the plant and whose consequence would be no more severe than normal service effects of the plant equipment. The performance analysis methodology which systematizes the methods and procedures to analyze the PRDBEs is as follows. Based on the operation mode suitable to the characteristics of the SMART NSSS, the corresponding PRDBEs and allowable range of process parameters for these events are deduced. With the developed control logic for each operation mode, the system thermalhydraulics are analyzed for the chosen PRDBEs using the system analysis code. Particularly, because of different system characteristics of SMART from the existing commercial nuclear power plants, the operation mode, PRDBEs, control logic, and analysis code should be consistent with the SMART design. This report presents the categories of the PRDBEs chosen based on each operation mode and the transition among these and the acceptance criteria for each PRDBE. It also includes the analysis methods and procedures for each PRDBE and the concept of the control logic for each operation mode. Therefore this report in which the overall details for SMART performance analysis are specified based on the current SMART design, would be utilized as a guide for the detailed performance analysis

  2. Relative Hazard Calculation Methodology

    International Nuclear Information System (INIS)

    DL Strenge; MK White; RD Stenner; WB Andrews

    1999-01-01

    The methodology presented in this document was developed to provide a means of calculating the RH ratios to use in developing useful graphic illustrations. The RH equation, as presented in this methodology, is primarily a collection of key factors relevant to understanding the hazards and risks associated with projected risk management activities. The RH equation has the potential for much broader application than generating risk profiles. For example, it can be used to compare one risk management activity with another, instead of just comparing it to a fixed baseline as was done for the risk profiles. If the appropriate source term data are available, it could be used in its non-ratio form to estimate absolute values of the associated hazards. These estimated values of hazard could then be examined to help understand which risk management activities are addressing the higher hazard conditions at a site. Graphics could be generated from these absolute hazard values to compare high-hazard conditions. If the RH equation is used in this manner, care must be taken to specifically define and qualify the estimated absolute hazard values (e.g., identify which factors were considered and which ones tended to drive the hazard estimation)

  3. Insights into PRA methodologies

    International Nuclear Information System (INIS)

    Gallagher, D.; Lofgren, E.; Atefi, B.; Liner, R.; Blond, R.; Amico, P.

    1984-08-01

    Probabilistic Risk Assessments (PRAs) for six nuclear power plants were examined to gain insight into how the choice of analytical methods can affect the results of PRAs. The PRA sreflectope considered was limited to internally initiated accidents sequences through core melt. For twenty methodological topic areas, a baseline or minimal methodology was specified. The choice of methods for each topic in the six PRAs was characterized in terms of the incremental level of effort above the baseline. A higher level of effort generally reflects a higher level of detail or a higher degree of sophistication in the analytical approach to a particular topic area. The impact on results was measured in terms of how additional effort beyond the baseline level changed the relative importance and ordering of dominant accident sequences compared to what would have been observed had methods corresponding to the baseline level of effort been employed. This measure of impact is a more useful indicator of how methods affect perceptions of plant vulnerabilities than changes in core melt frequency would be. However, the change in core melt frequency was used as a secondary measure of impact for nine topics where availability of information permitted. Results are presented primarily in the form of effort-impact matrices for each of the twenty topic areas. A suggested effort-impact profile for future PRAs is presented

  4. Scrum methodology in banking environment

    OpenAIRE

    Strihová, Barbora

    2015-01-01

    Bachelor thesis "Scrum methodology in banking environment" is focused on one of agile methodologies called Scrum and description of the methodology used in banking environment. Its main goal is to introduce the Scrum methodology and outline a real project placed in a bank focused on software development through a case study, address problems of the project, propose solutions of the addressed problems and identify anomalies of Scrum in software development constrained by the banking environmen...

  5. Experimental Economics: Some Methodological Notes

    OpenAIRE

    Fiore, Annamaria

    2009-01-01

    The aim of this work is presenting in a self-contained paper some methodological aspects as they are received in the current experimental literature. The purpose has been to make a critical review of some very influential papers dealing with methodological issues. In other words, the idea is to have a single paper where people first approaching experimental economics can find summarised (some) of the most important methodological issues. In particular, the focus is on some methodological prac...

  6. New features in MEDM

    International Nuclear Information System (INIS)

    Evans, K. Jr.

    1999-01-01

    MEDM, which is derived from Motif Editor and Display Manager, is the primary graphical interface to the EPICS control system. This paper describes new features that have been added to MEDM in the last two years. These features include new editing capabilities, a PV Info dialog box, a means of specifying limits and precision, a new implementation of the Cartesian Plot, new features for several objects, new capability for the Related Display, help, a user-configurable Execute Menu, reconfigured start-up options, and availability for Windows 95/98/NT. Over one hundred bugs have been fixed, and the program is quite stable and in extensive use

  7. Abdominal cocoon: sonographic features.

    Science.gov (United States)

    Vijayaraghavan, S Boopathy; Palanivelu, Chinnusamy; Sendhilkumar, Karuppusamy; Parthasarathi, Ramakrishnan

    2003-07-01

    An abdominal cocoon is a rare condition in which the small bowel is encased in a membrane. The diagnosis is usually established at surgery. Here we describe the sonographic features of this condition.

  8. Mesoblastic nephroma: Pathological features

    African Journals Online (AJOL)

    N.M. El-Badawy

    determined mainly by its histologic type, we found it worthwhile to elaborate more on the gross and microscopic features of ... behavior of mesoblastic nephroma is determined mainly by its his- .... However, it exhibits a nodular growth pattern at.

  9. Depth estimation of features in video frames with improved feature matching technique using Kinect sensor

    Science.gov (United States)

    Sharma, Kajal; Moon, Inkyu; Kim, Sung Gaun

    2012-10-01

    Estimating depth has long been a major issue in the field of computer vision and robotics. The Kinect sensor's active sensing strategy provides high-frame-rate depth maps and can recognize user gestures and human pose. This paper presents a technique to estimate the depth of features extracted from video frames, along with an improved feature-matching method. In this paper, we used the Kinect camera developed by Microsoft, which captured color and depth images for further processing. Feature detection and selection is an important task for robot navigation. Many feature-matching techniques have been proposed earlier, and this paper proposes an improved feature matching between successive video frames with the use of neural network methodology in order to reduce the computation time of feature matching. The features extracted are invariant to image scale and rotation, and different experiments were conducted to evaluate the performance of feature matching between successive video frames. The extracted features are assigned distance based on the Kinect technology that can be used by the robot in order to determine the path of navigation, along with obstacle detection applications.

  10. Feature Binding in Zebrafish

    Directory of Open Access Journals (Sweden)

    P Neri

    2012-07-01

    Full Text Available Binding operations are primarily ascribed to cortex or similarly complex avian structures. My experiments show that the zebrafish, a lower vertebrate lacking cortex, supports visual feature binding of form and motion for the purpose of social behavior. These results challenge the notion that feature binding may require highly evolved neural structures and demonstrate that the nervous system of lower vertebrates can afford unexpectedly complex computations.

  11. A methodology for Electric Power Load Forecasting

    Directory of Open Access Journals (Sweden)

    Eisa Almeshaiei

    2011-06-01

    Full Text Available Electricity demand forecasting is a central and integral process for planning periodical operations and facility expansion in the electricity sector. Demand pattern is almost very complex due to the deregulation of energy markets. Therefore, finding an appropriate forecasting model for a specific electricity network is not an easy task. Although many forecasting methods were developed, none can be generalized for all demand patterns. Therefore, this paper presents a pragmatic methodology that can be used as a guide to construct Electric Power Load Forecasting models. This methodology is mainly based on decomposition and segmentation of the load time series. Several statistical analyses are involved to study the load features and forecasting precision such as moving average and probability plots of load noise. Real daily load data from Kuwaiti electric network are used as a case study. Some results are reported to guide forecasting future needs of this network.

  12. The intersections between TRIZ and forecasting methodology

    Directory of Open Access Journals (Sweden)

    Georgeta BARBULESCU

    2010-12-01

    Full Text Available The authors’ intention is to correlate the basic knowledge in using the TRIZ methodology (Theory of Inventive Problem Solving or in Russian: Teoriya Resheniya Izobretatelskikh Zadatch as a problem solving tools meant to help the decision makers to perform more significant forecasting exercises. The idea is to identify the TRIZ features and instruments (40 inventive principles, i.e. for putting in evidence the noise and signal problem, for trend identification (qualitative and quantitative tendencies and support tools in technological forecasting, to make the decision-makers able to refine and to increase the level of confidence in the forecasting results. The interest in connecting TRIZ to forecasting methodology, nowadays, relates to the massive application of TRIZ methods and techniques for engineering system development world-wide and in growing application of TRIZ’s concepts and paradigms for improvements of non-engineering systems (including the business and economic applications.

  13. Geotechnical site assessment methodology

    International Nuclear Information System (INIS)

    Tunbridge, L.W.; Richards, L.R.

    1985-09-01

    A final report summarizing the research conducted on geotechnical site assessment methodology at the Carwynnen test mine in Cornwall. The geological setting of the test site in the Cornubian granite batholith is described. The effect of structure imposed by discontinuities on the engineering behaviour of rock masses is discussed and the scanline survey method of obtaining data on discontinuities in the rock mass is described. The applicability of some methods of statistical analysis for discontinuity data is reviewed. The requirement for remote geophysical methods of characterizing the mass is discussed and experiments using seismic and ultrasonic velocity measurements are reported. Methods of determining the in-situ stresses are described and the final results of a programme of in-situ stress measurements using the overcoring and hydrofracture methods are reported. (author)

  14. UNCOMMON SENSORY METHODOLOGIES

    Directory of Open Access Journals (Sweden)

    Vladimír Vietoris

    2015-02-01

    Full Text Available Sensory science is the young but the rapidly developing field of the food industry. Actually, the great emphasis is given to the production of rapid techniques of data collection, the difference between consumers and trained panel is obscured and the role of sensory methodologists is to prepare the ways for evaluation, by which a lay panel (consumers can achieve identical results as a trained panel. Currently, there are several conventional methods of sensory evaluation of food (ISO standards, but more sensory laboratories are developing methodologies that are not strict enough in the selection of evaluators, their mechanism is easily understandable and the results are easily interpretable. This paper deals with mapping of marginal methods used in sensory evaluation of food (new types of profiles, CATA, TDS, napping.

  15. Safety class methodology

    International Nuclear Information System (INIS)

    Donner, E.B.; Low, J.M.; Lux, C.R.

    1992-01-01

    DOE Order 6430.1A, General Design Criteria (GDC), requires that DOE facilities be evaluated with respect to ''safety class items.'' Although the GDC defines safety class items, it does not provide a methodology for selecting safety class items. The methodology described in this paper was developed to assure that Safety Class Items at the Savannah River Site (SRS) are selected in a consistent and technically defensible manner. Safety class items are those in the highest of four categories determined to be of special importance to nuclear safety and, merit appropriately higher-quality design, fabrication, and industrial test standards and codes. The identification of safety class items is approached using a cascading strategy that begins at the 'safety function' level (i.e., a cooling function, ventilation function, etc.) and proceeds down to the system, component, or structure level. Thus, the items that are required to support a safety function are SCls. The basic steps in this procedure apply to the determination of SCls for both new project activities, and for operating facilities. The GDC lists six characteristics of SCls to be considered as a starting point for safety item classification. They are as follows: 1. Those items whose failure would produce exposure consequences that would exceed the guidelines in Section 1300-1.4, ''Guidance on Limiting Exposure of the Public,'' at the site boundary or nearest point of public access 2. Those items required to maintain operating parameters within the safety limits specified in the Operational Safety Requirements during normal operations and anticipated operational occurrences. 3. Those items required for nuclear criticality safety. 4. Those items required to monitor the release of radioactive material to the environment during and after a Design Basis Accident. Those items required to achieve, and maintain the facility in a safe shutdown condition 6. Those items that control Safety Class Item listed above

  16. Using proliferation assessment methodologies for Safeguards-by-Design

    International Nuclear Information System (INIS)

    Van der Meer, K.; Rossa, R.; Turcanu, C.; Borella, A.

    2013-01-01

    MYRRHA, an accelerator driven system (ADS) is designed as a proton accelerator coupled to a liquid Pb-Bi spallation target, surrounded by a Pb-Bi cooled sub-critical neutron multiplying medium in a pool type configuration. An assessment based on three methodologies was made of the proliferation risks of the MYRRHA ADS in comparison with the BR2 MTR, an existing research reactor at the Belgian Nuclear Research Centre SCK-CEN. The used methodologies were the TOPS (Technical Opportunities to Increase the Proliferation Resistance of Nuclear Power Systems), the PR-PP and the INPRO methodologies. The various features of the methodologies are described and the results of the assessments are given and discussed. It is concluded that it would be useful to define one single methodology with two options to perform a quick and a more detailed assessment. The paper is followed by the slides of the presentation

  17. Situating methodology within qualitative research.

    Science.gov (United States)

    Kramer-Kile, Marnie L

    2012-01-01

    Qualitative nurse researchers are required to make deliberate and sometimes complex methodological decisions about their work. Methodology in qualitative research is a comprehensive approach in which theory (ideas) and method (doing) are brought into close alignment. It can be difficult, at times, to understand the concept of methodology. The purpose of this research column is to: (1) define qualitative methodology; (2) illuminate the relationship between epistemology, ontology and methodology; (3) explicate the connection between theory and method in qualitative research design; and 4) highlight relevant examples of methodological decisions made within cardiovascular nursing research. Although there is no "one set way" to do qualitative research, all qualitative researchers should account for the choices they make throughout the research process and articulate their methodological decision-making along the way.

  18. Handwriting: Feature Correlation Analysis for Biometric Hashes

    Science.gov (United States)

    Vielhauer, Claus; Steinmetz, Ralf

    2004-12-01

    In the application domain of electronic commerce, biometric authentication can provide one possible solution for the key management problem. Besides server-based approaches, methods of deriving digital keys directly from biometric measures appear to be advantageous. In this paper, we analyze one of our recently published specific algorithms of this category based on behavioral biometrics of handwriting, the biometric hash. Our interest is to investigate to which degree each of the underlying feature parameters contributes to the overall intrapersonal stability and interpersonal value space. We will briefly discuss related work in feature evaluation and introduce a new methodology based on three components: the intrapersonal scatter (deviation), the interpersonal entropy, and the correlation between both measures. Evaluation of the technique is presented based on two data sets of different size. The method presented will allow determination of effects of parameterization of the biometric system, estimation of value space boundaries, and comparison with other feature selection approaches.

  19. Handwriting: Feature Correlation Analysis for Biometric Hashes

    Directory of Open Access Journals (Sweden)

    Ralf Steinmetz

    2004-04-01

    Full Text Available In the application domain of electronic commerce, biometric authentication can provide one possible solution for the key management problem. Besides server-based approaches, methods of deriving digital keys directly from biometric measures appear to be advantageous. In this paper, we analyze one of our recently published specific algorithms of this category based on behavioral biometrics of handwriting, the biometric hash. Our interest is to investigate to which degree each of the underlying feature parameters contributes to the overall intrapersonal stability and interpersonal value space. We will briefly discuss related work in feature evaluation and introduce a new methodology based on three components: the intrapersonal scatter (deviation, the interpersonal entropy, and the correlation between both measures. Evaluation of the technique is presented based on two data sets of different size. The method presented will allow determination of effects of parameterization of the biometric system, estimation of value space boundaries, and comparison with other feature selection approaches.

  20. Multithreaded hybrid feature tracking for markerless augmented reality.

    Science.gov (United States)

    Lee, Taehee; Höllerer, Tobias

    2009-01-01

    We describe a novel markerless camera tracking approach and user interaction methodology for augmented reality (AR) on unprepared tabletop environments. We propose a real-time system architecture that combines two types of feature tracking. Distinctive image features of the scene are detected and tracked frame-to-frame by computing optical flow. In order to achieve real-time performance, multiple operations are processed in a synchronized multi-threaded manner: capturing a video frame, tracking features using optical flow, detecting distinctive invariant features, and rendering an output frame. We also introduce user interaction methodology for establishing a global coordinate system and for placing virtual objects in the AR environment by tracking a user's outstretched hand and estimating a camera pose relative to it. We evaluate the speed and accuracy of our hybrid feature tracking approach, and demonstrate a proof-of-concept application for enabling AR in unprepared tabletop environments, using bare hands for interaction.

  1. Imaging features of aggressive angiomyxoma

    International Nuclear Information System (INIS)

    Jeyadevan, N.N.; Sohaib, S.A.A.; Thomas, J.M.; Jeyarajah, A.; Shepherd, J.H.; Fisher, C.

    2003-01-01

    AIM: To describe the imaging features of aggressive angiomyxoma in a rare benign mesenchymal tumour most frequently arising from the perineum in young female patients. MATERIALS AND METHODS: We reviewed the computed tomography (CT) and magnetic resonance (MR) imaging features of patients with aggressive angiomyxoma who were referred to our hospital. The imaging features were correlated with clinical information and pathology in all patients. RESULTS: Four CT and five MR studies were available for five patients (all women, mean age 39, range 24-55). Three patients had recurrent tumour at follow-up. CT and MR imaging demonstrated a well-defined mass-displacing adjacent structures. The tumour was of low attenuation relative to muscle on CT. On MR, the tumour was isointense relative to muscle on T1-weighted image, hyperintense on T2-weighted image and enhanced avidly after gadolinium contrast with a characteristic 'swirled' internal pattern. MR imaging demonstrates the extent of the tumour and its relation to the pelvic floor. Recurrent tumour has a similar appearance to the primary lesion. CONCLUSION: The MR appearances of aggressive angiomyxomas are characteristic, and the diagnosis should be considered in any young woman presenting with a well-defined mass arising from the perineum. Jeyadevan, N. N. etal. (2003). Clinical Radiology58, 157--162

  2. Evolving Intelligent Systems Methodology and Applications

    CERN Document Server

    Angelov, Plamen; Kasabov, Nik

    2010-01-01

    From theory to techniques, the first all-in-one resource for EIS. There is a clear demand in advanced process industries, defense, and Internet and communication (VoIP) applications for intelligent yet adaptive/evolving systems. Evolving Intelligent Systems is the first self- contained volume that covers this newly established concept in its entirety, from a systematic methodology to case studies to industrial applications. Featuring chapters written by leading world experts, it addresses the progress, trends, and major achievements in this emerging research field, with a strong emphasis on th

  3. Development of a flight software testing methodology

    Science.gov (United States)

    Mccluskey, E. J.; Andrews, D. M.

    1985-01-01

    The research to develop a testing methodology for flight software is described. An experiment was conducted in using assertions to dynamically test digital flight control software. The experiment showed that 87% of typical errors introduced into the program would be detected by assertions. Detailed analysis of the test data showed that the number of assertions needed to detect those errors could be reduced to a minimal set. The analysis also revealed that the most effective assertions tested program parameters that provided greater indirect (collateral) testing of other parameters. In addition, a prototype watchdog task system was built to evaluate the effectiveness of executing assertions in parallel by using the multitasking features of Ada.

  4. The radiographic features of familial expansile osteolysis

    International Nuclear Information System (INIS)

    Crone, M.D.; Wallace, R.G.H.

    1990-01-01

    The radiographic features of a unique autosomal dominant bone dysplasia are presented. The features are classified as generalised and/or focal. Generalised features are either altered trabecular pattern or modelling abnormalities. Focal features comprise lytic areas which progressively enlarge, producing expansion of the bone and eventual disintegration due to fibrous and finally fatty replacement of the normal medulla. Almost 90% of these lesions occur in the appendicular skeleton. Clinically, hearing loss is the earliest manifestation of the disease, presenting sometimes as early as 4 years of age. Apical and cervical resorption of teeth is extremely common, resulting in premature loss of teeth. Radiologically, the differential diagnosis refers to Paget's disease, polyostotic fibrous dysplasia, and osteofibrous dysplasia. The progressive destruction of the bone is similar to massive osteolysis (Gorham's disease). The radiographic features in combination with the histopathology render the condition unique. (orig.)

  5. Psychopathological features in Noonan syndrome.

    Science.gov (United States)

    Perrino, Francesca; Licchelli, Serena; Serra, Giulia; Piccini, Giorgia; Caciolo, Cristina; Pasqualetti, Patrizio; Cirillo, Flavia; Leoni, Chiara; Digilio, Maria Cristina; Zampino, Giuseppe; Tartaglia, Marco; Alfieri, Paolo; Vicari, Stefano

    2018-01-01

    Noonan syndrome (NS) is an autosomal dominant disorder characterized by short stature, skeletal and haematological/lymphatic defects, distinctive facies, cryptorchidism, and a wide spectrum of congenital heart defects. Recurrent features also include variable cognitive deficits and behavioural problems. Recent research has been focused on the assessment of prevalence, age of onset and characterization of psychiatric features in this disorder. Herein, we evaluated the prevalence of attention deficit and hyperactivity disorder (ADHD), anxiety and depressive symptoms and syndromes in a cohort of individuals with clinical and molecular diagnosis of NS. The Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children Present and Lifetime version (K-SADS PL) has been used for the assessment of psychiatric disorders according to Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). Multidimensional Anxiety Scale for Children (MASC) and the Children's Depression Inventory (CDI) have been assessed for the evaluation of anxiety and depressive symptoms and syndromes, whereas Conners Teacher and Parent Rating Scales-long version (CRS-R) have been used to evaluate ADHD. The study included 27 individuals (67% males) with an average age of 10.4 years (range 6-18 years) receiving molecular diagnosis of NS or a clinically related condition, evaluated and treated at the Neuropsychiatric Unit of Children's Hospital Bambino Gesù and at the Center for Rare Diseases of Fondazione Policlinico Universitario Agostino Gemelli, in Rome. Twenty individuals showed mutations in PTPN11, five in SOS1 and two in SHOC2. The mean IQ was 94 (Standard Deviation = 17, min = 56, max = 130). Seventy percent of the individuals (n = 19; 95% Confidence Interval = 52-85%) showed ADHD features, with six individuals reaching DSM-IV-TR criteria for ADHD disorder, and thirteen showing subsyndromal traits. Symptoms or syndrome of anxiety were present in 37% of the cohort

  6. Personality Features of Motorists

    Directory of Open Access Journals (Sweden)

    Andrej Justinek

    1997-12-01

    Full Text Available Justinek tries to answer the question whether or not motorists have specific personality features which predispose them for safe and well-mannered driving. A good driver should have sensory abilities which enable psycho-motor coordiation of a vehicle, intellectual and cognitive features that are important for solving problems in new, unknown situations, and emotional and motivational trails defining a driver's maturity. Justmek advocates the belief that in training future drivers greater attention should be paid to developing these features which are vital for safe driving and appropriate behaviour of drivers in traffic. He also suggests certain learning methods leading to development of the above­ mentioned personality traits. Justinek introduces the notion of the 'philosophy of driving' as an essential educational category in training future drivers.

  7. Feature displacement interpolation

    DEFF Research Database (Denmark)

    Nielsen, Mads; Andresen, Per Rønsholt

    1998-01-01

    Given a sparse set of feature matches, we want to compute an interpolated dense displacement map. The application may be stereo disparity computation, flow computation, or non-rigid medical registration. Also estimation of missing image data, may be phrased in this framework. Since the features...... often are very sparse, the interpolation model becomes crucial. We show that a maximum likelihood estimation based on the covariance properties (Kriging) show properties more expedient than methods such as Gaussian interpolation or Tikhonov regularizations, also including scale......-selection. The computational complexities are identical. We apply the maximum likelihood interpolation to growth analysis of the mandibular bone. Here, the features used are the crest-lines of the object surface....

  8. Key Features of the Manufacturing Vision Development Process

    DEFF Research Database (Denmark)

    Dukovska-Popovska, Iskra; Riis, Jens Ove; Boer, Harry

    2005-01-01

    of action research. The methodology recommends wide participation of people from different hierarchical and functional positions, who engage in a relatively short, playful and creative process and come up with a vision (concept) for the future manufacturing system in the company. Based on three case studies......This paper discusses the key features of the process of Manufacturing Vision Development, a process that enables companies to develop their future manufacturing concept. The basis for the process is a generic five-phase methodology (Riis and Johansen 2003) developed as a result of ten years...... of companies going through the initial phases of the methodology, this research identified the key features of the Manufacturing Vision Development process. The paper elaborates the key features by defining them, discussing how and when they can appear, and how they influence the process....

  9. Methodological Problems of Nanotechnoscience

    Science.gov (United States)

    Gorokhov, V. G.

    Recently, we have reported on the definitions of nanotechnology as a new type of NanoTechnoScience and on the nanotheory as a cluster of the different natural and engineering theories. Nanotechnology is not only a new type of scientific-engineering discipline, but it evolves also in a “nonclassical” way. Nanoontology or nano scientific world view has a function of the methodological orientation for the choice the theoretical means and methods toward a solution to the scientific and engineering problems. This allows to change from one explanation and scientific world view to another without any problems. Thus, nanotechnology is both a field of scientific knowledge and a sphere of engineering activity, in other words, NanoTechnoScience is similar to Systems Engineering as the analysis and design of large-scale, complex, man/machine systems but micro- and nanosystems. Nano systems engineering as well as Macro systems engineering includes not only systems design but also complex research. Design orientation has influence on the change of the priorities in the complex research and of the relation to the knowledge, not only to “the knowledge about something”, but also to the knowledge as the means of activity: from the beginning control and restructuring of matter at the nano-scale is a necessary element of nanoscience.

  10. Methodological themes and variations

    International Nuclear Information System (INIS)

    Tetlock, P.E.

    1989-01-01

    This paper reports on the tangible progress that has been made in clarifying the underlying processes that affect both the likelihood of war in general and of nuclear war in particular. It also illustrates how difficult it is to make progress in this area. Nonetheless, what has been achieved should not be minimized. We have learned a good deal on both the theoretical and the methodological fronts and, perhaps, most important, we have learned a good deal about the limits of our knowledge. Knowledge of our ignorance---especially in a policy domain where confident, even glib, causal assertions are so common---can be a major contribution in itself. The most important service the behavioral and social sciences can currently provide to the policy making community may well be to make thoughtful skepticism respectable: to sensitize those who make key decisions to the uncertainty surrounding our understanding of international conflict and to the numerous qualifications that now need to be attached to simple causal theories concerning the origins of war

  11. Engineering radioecology: Methodological considerations

    International Nuclear Information System (INIS)

    Nechaev, A.F.; Projaev, V.V.; Sobolev, I.A.; Dmitriev, S.A.

    1995-01-01

    The term ''radioecology'' has been widely recognized in scientific and technical societies. At the same time, this scientific school (radioecology) does not have a precise/generally acknowledged structure, unified methodical basis, fixed subjects of investigation, etc. In other words, radioecology is a vast, important but rather amorphous conglomerate of various ideas, amalgamated mostly by their involvement in biospheric effects of ionizing radiation and some conceptual stereotypes. This paradox was acceptable up to a certain time. However, with the termination of the Cold War and because of remarkable political changes in the world, it has become possible to convert the problem of environmental restoration from the scientific sphere in particularly practical terms. Already the first steps clearly showed an imperfection of existing technologies, managerial and regulatory schemes; lack of qualified specialists, relevant methods and techniques; uncertainties in methodology of decision-making, etc. Thus, building up (or maybe, structuring) of special scientific and technological basis, which the authors call ''engineering radioecology'', seems to be an important task. In this paper they endeavored to substantiate the last thesis and to suggest some preliminary ideas concerning the subject matter of engineering radioecology

  12. The Development of Explicit Memory for Basic Perceptual Features.

    Science.gov (United States)

    Gulya, Michelle; Rossi-George, Alba; Hartshorn, Kristen; Vieira, Aurora; Rovee-Collier, Carolyn; Johnson, Marcia K.; Chalfonte, Barbara L.

    2002-01-01

    Three experiments with 164 individuals between 4 and 80 years old examined age-related changes in explicit memory for three perceptual features: item identity, color, and location. Findings indicated that performance on explicit memory tests was not a consistent inverted U-shaped function of age across various features, but depended on the…

  13. Aging Brain, Aging Mind.

    Science.gov (United States)

    Selkoe, Dennis J.

    1992-01-01

    Discusses the aging process related to physical changes of the human neural structure involved in learning, memory, and reasoning. Presents evidence that indicates such alterations do not necessarily signal the decline in cognitive function. Vignettes provide images of brain structures involved in learning, memory, and reasoning; hippocampal…

  14. Engineering features of ISX

    International Nuclear Information System (INIS)

    Lousteau, D.C.; Jernigan, T.C.; Schaffer, M.J.; Hussung, R.O.

    1975-01-01

    ISX, an Impurity Study Experiment, is presently being designed at Oak Ridge National Laboratory as a joint scientific effort between ORNL and General Atomic Company. ISX is a moderate size tokamak dedicated to the study of impurity production, diffusion, and control. The significant engineering features of this device are discussed

  15. Application of methodological approach to selection of sportswomen to calisthenics teams for group exercises, considering compatibility factor

    Directory of Open Access Journals (Sweden)

    O.S. Kozhanova

    2015-04-01

    Full Text Available Purpose: motivation of methodological approach to selection of sportswomen to calisthenics teams for group exercises considering compatibility factor. Material: in the research 40 high qualification sportswomen of 17-23 yrs age with sport experience of 11-16 years participated. With cluster analysis 10 gymnasts with morphological indicators, meeting modern standards of group exercises were selected. Results: we found 5 generalized factors, which characterize structure of selection to teams and determines 72% of dispersion. Influence of kinds and connected with them criteria of compatibility on efficiency of gymnasts’ competition functioning were also determined. The authors substantiated methodological approach to selection of sportswomen to calisthenics teams for group exercises, considering compatibility factor. Conclusions: in selection to calisthenics teams for group exercises it is purposeful to realize complex registration of compatibility kinds, considering gymnasts’ similar features by recommended indicators.

  16. Transmission pricing: paradigms and methodologies

    Energy Technology Data Exchange (ETDEWEB)

    Shirmohammadi, Dariush [Pacific Gas and Electric Co., San Francisco, CA (United States); Vieira Filho, Xisto; Gorenstin, Boris [Centro de Pesquisas de Energia Eletrica (CEPEL), Rio de Janeiro, RJ (Brazil); Pereira, Mario V.P. [Power System Research, Rio de Janeiro, RJ (Brazil)

    1994-12-31

    In this paper we describe the principles of several paradigms and methodologies for pricing transmission services. The paper outlines some of the main characteristics of these paradigms and methodologies such as where they may be used for best results. Due to their popularity, power flow based MW-mile and short run marginal cost pricing methodologies will be covered in some detail. We conclude the paper with examples of the application of these two pricing methodologies for pricing transmission services in Brazil. (author) 25 refs., 2 tabs.

  17. Analytical methodology for nuclear safeguards

    International Nuclear Information System (INIS)

    Ramakumar, K.L.

    2011-01-01

    This paper attempts to briefly describe the analytical methodologies available and also highlight some of the challenges, expectations from nuclear material accounting and control (NUMAC) point of view

  18. THE ASSESSMENT METHODOLOGIES PTELR, ADRI AND CAE – THREE METHODOLOGIES FOR COORDINATING THE EFFORTS TO IMPROVE THE ORGANIZATIONAL PROCESSES TO ACHIEVE EXCELLENCE

    OpenAIRE

    Cristina Raluca POPESCU; Gheorghe N. POPESCU

    2015-01-01

    In the paper “The Assessment Methodologies PTELR, ADRI and CAE – Three Methodologies for Coordinating the Efforts to Improve the Organizational Processes to Achieve Excellence” the authors present the basic features of the assessment methodologies PTELR, ADRI and CAE that are designed to coordinate the efforts to improve the organizational processes in order to achieve excellence. In the first part of the paper (the introduction of the paper), the authors present the general background concer...

  19. Country report: a methodology

    International Nuclear Information System (INIS)

    Colin, A.

    2013-01-01

    This paper describes a methodology which could be applicable to establish a country report. In the framework of nuclear non proliferation appraisal and IAEA safeguards implementation, it is important to be able to assess the potential existence of undeclared nuclear materials and activities as undeclared facilities in the country under review. In our views a country report should aim at providing detailed information on nuclear related activities for each country examined taken 'as a whole' such as nuclear development, scientific and technical capabilities, etc. In order to study a specific country, we need to know if there is already an operating nuclear civil programme or not. In the first case, we have to check carefully if it could divert nuclear material, if there are misused declared facilities or if they operate undeclared facilities and conduct undeclared activities aiming at manufacturing nuclear weapon. In the second case, we should pay attention to the development of a nuclear civil project. A country report is based on a wide span of information (most of the time coming from open sources but sometimes coming also from confidential or private ones). Therefore, it is important to carefully check the nature and the credibility (reliability?) of these sources through cross-check examination. Eventually, it is necessary to merge information from different sources and apply an expertise filter. We have at our disposal a lot of performing tools to help us to assess, understand and evaluate the situation (cartography, imagery, bibliometry, etc.). These tools allow us to offer the best conclusions as far as possible. The paper is followed by the slides of the presentation. (author)

  20. Microbiological Methodology in Astrobiology

    Science.gov (United States)

    Abyzov, S. S.; Gerasimenko, L. M.; Hoover, R. B.; Mitskevich, I. N.; Mulyukin, A. L.; Poglazova, M. N.; Rozanov, A. Y.

    2005-01-01

    Searching for life in astromaterials to be delivered from the future missions to extraterrestrial bodies is undoubtedly related to studies of the properties and signatures of living microbial cells and microfossils on Earth. As model terrestrial analogs of Martian polar subsurface layers are often regarded the Antarctic glacier and Earth permafrost habitats where alive microbial cells preserved viability for millennia years due to entering the anabiotic state. For the future findings of viable microorganisms in samples from extraterrestrial objects, it is important to use a combined methodology that includes classical microbiological methods, plating onto nutrient media, direct epifluorescence and electron microscopy examinations, detection of the elemental composition of cells, radiolabeling techniques, PCR and FISH methods. Of great importance is to ensure authenticity of microorganisms (if any in studied samples) and to standardize the protocols used to minimize a risk of external contamination. Although the convincing evidence of extraterrestrial microbial life will may come from the discovery of living cells in astromaterials, biomorphs and microfossils must also be regarded as a target in search of life evidence bearing in mind a scenario that alive microorganisms had not be preserved and underwent mineralization. Under the laboratory conditions, processes that accompanied fossilization of cyanobacteria were reconstructed, and artificially produced cyanobacterial stromatolites resembles by their morphological properties those found in natural Earth habitats. Regarding the vital importance of distinguishing between biogenic and abiogenic signatures and between living and fossil microorganisms in analyzed samples, it is worthwhile to use some previously developed approaches based on electron microscopy examinations and analysis of elemental composition of biomorphs in situ and comparison with the analogous data obtained for laboratory microbial cultures and

  1. Kaupapa Maori Methodology: Trusting the Methodology through Thick and Thin

    Science.gov (United States)

    Hiha, Anne Aroha

    2016-01-01

    Kaupapa Maori is thoroughly theorised in academia in Aotearoa and those wishing to use it as their research methodology can find support through the writing of a number of Maori academics. What is not so well articulated, is the experiential voice of those who have used Kaupapa Maori as research methodology. My identity as a Maori woman…

  2. Methodological quality of guidelines in gastroenterology.

    Science.gov (United States)

    Malheiro, Rui; de Monteiro-Soares, Matilde; Hassan, Cesare; Dinis-Ribeiro, Mário

    2014-06-01

    Clinical guidelines are a common feature in modern endoscopy practice and they are being produced faster than ever. However, their methodological quality is rarely assessed. This study evaluated the methodological quality of current clinical guidelines in the field of gastroenterology, with an emphasis on endoscopy. Practice guidelines published by the American College of Gastroenterology (ACG), American Gastroenterological Association (AGA), American Society for Gastrointestinal Endoscopy (ASGE), European Society of Gastrointestinal Endoscopy (ESGE), British Society of Gastroenterology (BSG), National Institute for Health and Care Excellence (NICE), and the Scottish Intercollegiate Guidelines Network (SIGN) were searched between September and October 2012 and evaluated using the AGREE II (Appraisal of Guidelines for Research and Evaluation) instrument (23 items, scores 1 - 7 for each item; higher scores mean better quality). A total of 100 guidelines were assessed. The mean number of items scoring 6 or 7 per guideline was 9.2 (out of 23 items). Overall, 99 % of guidelines failed to include the target population in the development process, and 96 % did not report facilitators and barriers to guideline application. In addition, 86 % did not include advice or tools, and 94 % did not present monitoring or auditing criteria. The global methodological quality of clinical guidelines in the field of gastroenterology is poor, particularly regarding involvement of the target population in the development of guidelines and in the provision of clear suggestions to practitioners. © Georg Thieme Verlag KG Stuttgart · New York.

  3. About methodology to study plant uptake of radionuclides from soil

    International Nuclear Information System (INIS)

    Tuleubaev, B.A.; Ptitskaya, L.D.

    2000-01-01

    This paper presents methodology for studying particular features of radionuclides uptake by plants from contaminated soil as applied to the use of the former Semipalatinsk tet site territory, which are dependent upon physical-chemical and physical-mechanical properties of soil and biological peculiarities of meadow-pasture vegetation. (author)

  4. Identification of Nigerian English idioms: A methodological perspective

    African Journals Online (AJOL)

    The task becomes more challenging when the feature of interest involves figurative meaning such as idioms and idiomatic expressions. In a recently completed project that sought to examine idioms in Nigerian English, questions and issues about methodology were raised. Among these were the questions of how idioms in ...

  5. Probabilistic risk assessment methodology

    International Nuclear Information System (INIS)

    Shinaishin, M.A.

    1988-06-01

    The objective of this work is to provide the tools necessary for clear identification of: the purpose of a Probabilistic Risk Study, the bounds and depth of the study, the proper modeling techniques to be used, the failure modes contributing to the analysis, the classical and baysian approaches for manipulating data necessary for quantification, ways for treating uncertainties, and available computer codes that may be used in performing such probabilistic analysis. In addition, it provides the means for measuring the importance of a safety feature to maintaining a level of risk at a Nuclear Power Plant and the worth of optimizing a safety system in risk reduction. In applying these techniques so that they accommodate our national resources and needs it was felt that emphasis should be put on the system reliability analysis level of PRA. Objectives of such studies could include: comparing systems' designs of the various vendors in the bedding stage, and performing grid reliability and human performance analysis using national specific data. (author)

  6. Probabilistic risk assessment methodology

    Energy Technology Data Exchange (ETDEWEB)

    Shinaishin, M A

    1988-06-15

    The objective of this work is to provide the tools necessary for clear identification of: the purpose of a Probabilistic Risk Study, the bounds and depth of the study, the proper modeling techniques to be used, the failure modes contributing to the analysis, the classical and baysian approaches for manipulating data necessary for quantification, ways for treating uncertainties, and available computer codes that may be used in performing such probabilistic analysis. In addition, it provides the means for measuring the importance of a safety feature to maintaining a level of risk at a Nuclear Power Plant and the worth of optimizing a safety system in risk reduction. In applying these techniques so that they accommodate our national resources and needs it was felt that emphasis should be put on the system reliability analysis level of PRA. Objectives of such studies could include: comparing systems' designs of the various vendors in the bedding stage, and performing grid reliability and human performance analysis using national specific data. (author)

  7. Probabilistic population aging

    Science.gov (United States)

    2017-01-01

    We merge two methodologies, prospective measures of population aging and probabilistic population forecasts. We compare the speed of change and variability in forecasts of the old age dependency ratio and the prospective old age dependency ratio as well as the same comparison for the median age and the prospective median age. While conventional measures of population aging are computed on the basis of the number of years people have already lived, prospective measures are computed also taking account of the expected number of years they have left to live. Those remaining life expectancies change over time and differ from place to place. We compare the probabilistic distributions of the conventional and prospective measures using examples from China, Germany, Iran, and the United States. The changes over time and the variability of the prospective indicators are smaller than those that are observed in the conventional ones. A wide variety of new results emerge from the combination of methodologies. For example, for Germany, Iran, and the United States the likelihood that the prospective median age of the population in 2098 will be lower than it is today is close to 100 percent. PMID:28636675

  8. MRI features of chondroblastoma

    International Nuclear Information System (INIS)

    Cheng Xiaoguang; Liu Xia; Cheng Kebin; Liu Wei

    2009-01-01

    Objective: To evaluate the MR imaging features of chondroblastoma. Methods: MRI examinations of 20 patients with histological proven chondmblastoma were reviewed retrospectively. The MRI findings of chondroblastoma including the signal intensity, the shape, the growth patterns, and the surrounding bone marrow edema and the adjacent soft tissue edema, the periosteal reaction, the adjacent joint effusion were analyzed. Results: All 20 cases demonstrated heterogeneous MR signal intensity on T 1 WI and T 2 WI images and showed lobular margins. Sixteen cases demonstrated expansive growth patterns. Surrounding bone marrow edema was found in 18 cases and adjacent soft tissue edema in 14 cases. Periosteal reaction was identified in 6 cases. In 7 cases the tumor extended to adjacent soft tissue. Adjacent joint effusion was visible on MRI in 6 cases. Conclusion: Heterogeneous signal intensity, lobular margins and expansive growth pattern, adjacent bone marrow and soft tissue edema were the common features of chondroblastoma on MRI. (authors)

  9. Imaging features of thalassemia

    Energy Technology Data Exchange (ETDEWEB)

    Tunaci, M.; Tunaci, A.; Engin, G.; Oezkorkmaz, B.; Acunas, G.; Acunas, B. [Dept. of Radiology, Istanbul Univ. (Turkey); Dincol, G. [Dept. of Internal Medicine, Istanbul Univ. (Turkey)

    1999-07-01

    Thalassemia is a kind of chronic, inherited, microcytic anemia characterized by defective hemoglobin synthesis and ineffective erythropoiesis. In all thalassemias clinical features that result from anemia, transfusional, and absorptive iron overload are similar but vary in severity. The radiographic features of {beta}-thalassemia are due in large part to marrow hyperplasia. Markedly expanded marrow space lead to various skeletal manifestations including spine, skull, facial bones, and ribs. Extramedullary hematopoiesis (ExmH), hemosiderosis, and cholelithiasis are among the non-skeletal manifestations of thalassemia. The skeletal X-ray findings show characteristics of chronic overactivity of the marrow. In this article both skeletal and non-skeletal manifestations of thalassemia are discussed with an overview of X-ray findings, including MRI and CT findings. (orig.)

  10. Imaging features of thalassemia

    International Nuclear Information System (INIS)

    Tunaci, M.; Tunaci, A.; Engin, G.; Oezkorkmaz, B.; Acunas, G.; Acunas, B.; Dincol, G.

    1999-01-01

    Thalassemia is a kind of chronic, inherited, microcytic anemia characterized by defective hemoglobin synthesis and ineffective erythropoiesis. In all thalassemias clinical features that result from anemia, transfusional, and absorptive iron overload are similar but vary in severity. The radiographic features of β-thalassemia are due in large part to marrow hyperplasia. Markedly expanded marrow space lead to various skeletal manifestations including spine, skull, facial bones, and ribs. Extramedullary hematopoiesis (ExmH), hemosiderosis, and cholelithiasis are among the non-skeletal manifestations of thalassemia. The skeletal X-ray findings show characteristics of chronic overactivity of the marrow. In this article both skeletal and non-skeletal manifestations of thalassemia are discussed with an overview of X-ray findings, including MRI and CT findings. (orig.)

  11. A methodology for social experimentation

    DEFF Research Database (Denmark)

    Ravn, Ib

    A methodology is outlined whereby one may improve the performance of a social system to the satisfaction of its stakeholders, that is, facilitate desirable social and organizational transformations......A methodology is outlined whereby one may improve the performance of a social system to the satisfaction of its stakeholders, that is, facilitate desirable social and organizational transformations...

  12. Workshops as a Research Methodology

    Science.gov (United States)

    Ørngreen, Rikke; Levinsen, Karin

    2017-01-01

    This paper contributes to knowledge on workshops as a research methodology, and specifically on how such workshops pertain to e-learning. A literature review illustrated that workshops are discussed according to three different perspectives: workshops as a means, workshops as practice, and workshops as a research methodology. Focusing primarily on…

  13. Methodological Pluralism and Narrative Inquiry

    Science.gov (United States)

    Michie, Michael

    2013-01-01

    This paper considers how the integral theory model of Nancy Davis and Laurie Callihan might be enacted using a different qualitative methodology, in this case the narrative methodology. The focus of narrative research is shown to be on "what meaning is being made" rather than "what is happening here" (quadrant 2 rather than…

  14. Building ASIPS the Mescal methodology

    CERN Document Server

    Gries, Matthias

    2006-01-01

    A number of system designers use ASIP's rather than ASIC's to implement their system solutions. This book gives a comprehensive methodology for the design of these application-specific instruction processors (ASIPs). It includes demonstrations of applications of the methodologies using the Tipi research framework.

  15. A methodology for software documentation

    OpenAIRE

    Torres Júnior, Roberto Dias; Ahlert, Hubert

    2000-01-01

    With the growing complexity of window based software and the use of object-oriented, the development of software is getting more complex than ever. Based on that, this article intends to present a methodology for software documentation and to analyze our experience and how this methodology can aid the software maintenance

  16. Model Checking Feature Interactions

    DEFF Research Database (Denmark)

    Le Guilly, Thibaut; Olsen, Petur; Pedersen, Thomas

    2015-01-01

    This paper presents an offline approach to analyzing feature interactions in embedded systems. The approach consists of a systematic process to gather the necessary information about system components and their models. The model is first specified in terms of predicates, before being refined to t...... to timed automata. The consistency of the model is verified at different development stages, and the correct linkage between the predicates and their semantic model is checked. The approach is illustrated on a use case from home automation....

  17. New learning resource features CERN

    CERN Multimedia

    Katarina Anthony

    2011-01-01

    A new educational website, STEM Works, has been launched this month, presenting science and technology in an industrial context for students aged 11-14. Developed with contributions from CERN, the site highlights the Laboratory as a “real-world” example of the opportunities available to science graduates. While the site was developed in Northern Ireland, STEM Works addresses issues of global relevance.   Students share their projects with Steve Myers, Richard Hanna (CCEA), and Catriona Ruane (Education Minister). STEM stands for Science, Technology, Engineering and Mathematics – the four cornerstones of the curriculum featured on the STEM Works website. It is part of a nationwide push in Northern Ireland to highlight how important STEM subjects are to both academia and industry. CERN worked closely with the Northern Ireland Council for the Curriculum, Examinations and Assessment (CCEA) to develop educational content for the site. “The CCEA STEM Works site i...

  18. Acromegaly: clinical features at diagnosis.

    Science.gov (United States)

    Vilar, Lucio; Vilar, Clarice Freitas; Lyra, Ruy; Lyra, Raissa; Naves, Luciana A

    2017-02-01

    Acromegaly is a rare and underdiagnosed disorder caused, in more than 95% of cases, by a growth hormone (GH)-secreting pituitary adenoma. The GH hypersecretion leads to overproduction of insulin-like growth factor 1 (IGF-1) which results in a multisystem disease characterized by somatic overgrowth, multiple comorbidities, physical disfigurement, and increased mortality. This article aims to review the clinical features of acromegaly at diagnosis. Acromegaly affects both males and females equally and the average age at diagnosis ranges from 40 to 50 years (up to 5% of cases acromegaly is often diagnosed five to more than ten years after its onset. The typical coarsening of facial features include furrowing of fronthead, pronounced brow protrusion, enlargement of the nose and the ears, thickening of the lips, skin wrinkles and nasolabial folds, as well as mandibular prognathism that leads to dental malocclusion and increased interdental spacing. Excessive growth of hands and feet (predominantly due to soft tissue swelling) is present in the vast majority of acromegalic patients. Gigantism accounts for up to 5% of cases and occurs when the excess of GH becomes manifest in the young, before the epiphyseal fusion. The disease also has rheumatologic, cardiovascular, respiratory, neoplastic, neurological, and metabolic manifestations which negatively impact its prognosis and patients quality of life. Less than 15% of acromegalic patients actively seek medical attention for change in appearance or enlargement of the extremities. The presentation of acromegaly is more often related to its systemic comorbidities or to local tumor effects.

  19. RESEARCH OF CLASSIFICATION FEATURES OF THE FINANCIAL CONTROL

    Directory of Open Access Journals (Sweden)

    Knarik K. Arabyan

    2013-01-01

    Full Text Available One of the major problems is an improvement of classification features in the financial control theory. There is not a consensus concerning the form classification and the methods of financial control. This factor hinders the development of methodology and investigation of other issues of the financial control theory. The author summarizes scientists’ approaches to studying the classification features of financial control in the article.

  20. Fusion of Multimodal Biometrics using Feature and Score Level Fusion

    OpenAIRE

    Mohana Prakash, S.; Betty, P.; Sivanarulselvan, K.

    2016-01-01

    Biometrics is used to uniquely identify a person‘s individual based on physical and behavioural characteristics. Unimodal biometric system contains various problems such as degree of freedom, spoof attacks, non-universality, noisy data and error rates. Multimodal biometrics is introduced to overcome the limitations in Unimodal biometrics. The presented methodology extracts the features of four biometric traits such as fingerprint, palm, iris and retina. Then extracted features are fused in th...

  1. Methodology of Neural Design: Applications in Microwave Engineering

    Directory of Open Access Journals (Sweden)

    Z. Raida

    2006-06-01

    Full Text Available In the paper, an original methodology for the automatic creation of neural models of microwave structures is proposed and verified. Following the methodology, neural models of the prescribed accuracy are built within the minimum CPU time. Validity of the proposed methodology is verified by developing neural models of selected microwave structures. Functionality of neural models is verified in a design - a neural model is joined with a genetic algorithm to find a global minimum of a formulated objective function. The objective function is minimized using different versions of genetic algorithms, and their mutual combinations. The verified methodology of the automated creation of accurate neural models of microwave structures, and their association with global optimization routines are the most important original features of the paper.

  2. AEGIS methodology and a perspective from AEGIS methodology demonstrations

    International Nuclear Information System (INIS)

    Dove, F.H.

    1981-03-01

    Objectives of AEGIS (Assessment of Effectiveness of Geologic Isolation Systems) are to develop the capabilities needed to assess the post-closure safety of waste isolation in geologic formation; demonstrate these capabilities on reference sites; apply the assessment methodology to assist the NWTS program in site selection, waste package and repository design; and perform repository site analyses for the licensing needs of NWTS. This paper summarizes the AEGIS methodology, the experience gained from methodology demonstrations, and provides an overview in the following areas: estimation of the response of a repository to perturbing geologic and hydrologic events; estimation of the transport of radionuclides from a repository to man; and assessment of uncertainties

  3. Learning Motion Features for Example-Based Finger Motion Estimation for Virtual Characters

    Science.gov (United States)

    Mousas, Christos; Anagnostopoulos, Christos-Nikolaos

    2017-09-01

    This paper presents a methodology for estimating the motion of a character's fingers based on the use of motion features provided by a virtual character's hand. In the presented methodology, firstly, the motion data is segmented into discrete phases. Then, a number of motion features are computed for each motion segment of a character's hand. The motion features are pre-processed using restricted Boltzmann machines, and by using the different variations of semantically similar finger gestures in a support vector machine learning mechanism, the optimal weights for each feature assigned to a metric are computed. The advantages of the presented methodology in comparison to previous solutions are the following: First, we automate the computation of optimal weights that are assigned to each motion feature counted in our metric. Second, the presented methodology achieves an increase (about 17%) in correctly estimated finger gestures in comparison to a previous method.

  4. Features of MCNP6

    International Nuclear Information System (INIS)

    Goorley, T.; James, M.; Booth, T.; Brown, F.; Bull, J.; Cox, L.J.; Durkee, J.; Elson, J.; Fensin, M.; Forster, R.A.; Hendricks, J.; Hughes, H.G.; Johns, R.; Kiedrowski, B.; Martz, R.; Mashnik, S.; McKinney, G.; Pelowitz, D.; Prael, R.; Sweezy, J.

    2016-01-01

    Highlights: • MCNP6 is simply and accurately described as the merger of MCNP5 and MCNPX capabilities, but it is much more than the sum of these two computer codes. • MCNP6 is the result of six years of effort by the MCNP5 and MCNPX code development teams. • These groups of people, residing in Los Alamos National Laboratory’s X Computational Physics Division, Monte Carlo Codes Group (XCP-3) and Nuclear Engineering and Nonproliferation Division, Radiation Transport Modeling Team (NEN-5) respectively, have combined their code development efforts to produce the next evolution of MCNP. • While maintenance and major bug fixes will continue for MCNP5 1.60 and MCNPX 2.7.0 for upcoming years, new code development capabilities only will be developed and released in MCNP6. • In fact, the initial release of MCNP6 contains numerous new features not previously found in either code. • These new features are summarized in this document. • Packaged with MCNP6 is also the new production release of the ENDF/B-VII.1 nuclear data files usable by MCNP. • The high quality of the overall merged code, usefulness of these new features, along with the desire in the user community to start using the merged code, have led us to make the first MCNP6 production release: MCNP6 version 1. • High confidence in the MCNP6 code is based on its performance with the verification and validation test suites, comparisons to its predecessor codes, our automated nightly software debugger tests, the underlying high quality nuclear and atomic databases, and significant testing by many beta testers. - Abstract: MCNP6 can be described as the merger of MCNP5 and MCNPX capabilities, but it is much more than the sum of these two computer codes. MCNP6 is the result of six years of effort by the MCNP5 and MCNPX code development teams. These groups of people, residing in Los Alamos National Laboratory’s X Computational Physics Division, Monte Carlo Codes Group (XCP-3) and Nuclear Engineering and

  5. Pulmonary vasculitis: imaging features

    International Nuclear Information System (INIS)

    Seo, Joon Beom; Im, Jung Gi; Chung, Jin Wook; Goo, Jin Mo; Park, Jae Hyung; Yeon, Kyung Mo; Song, Jae Woo

    1999-01-01

    Vasculitis is defined as an inflammatory process involving blood vessels, and can lead to destruction of the vascular wall and ischemic damage to the organs supplied by these vessels. The lung is commonly affected. A number of attempts have been made to classify and organize pulmonary vasculitis, but because the clinical manifestations and pathologic features of the condition overlap considerably, these afforts have failed to achieve a consensus. We classified pulmonary vasculitis as belonging to either the angitiis-granulomatosis group, the diffuse pulmonary hemorrhage with capillaritis group, or 'other'. Characteristic radiographic and CT findings of the different types of pulmonary vasculitis are illustrated, with a brief discussion of the respective disease entities

  6. Onychomatricoma with misleading features.

    Science.gov (United States)

    Fayol, J; Baran, R; Perrin, C; Labrousse, F

    2000-01-01

    Onychomatricoma is a rare tumour of the nail matrix with peculiar clinical and histological features and electron microscopic findings. We report on 5 cases with appearances which were misleading. Three presented as longitudinal melanonychia, a previously unreported observation. One case had the appearance of a cutaneous horn. In 3 of the 5 cases the tumour was associated with an onychomycosis and this may thus have been a predisposing factor in the secondary fungal infestation. Onychomatricoma appears as a multi-faceted tumour which can be mimicked by longitudinal melanonychia and/or onychomycosis.

  7. Aging and Circadian Rhythms

    Science.gov (United States)

    Duffy, Jeanne F.; Zitting, Kirsi-Marja; Chinoy, Evan D.

    2015-01-01

    Aging is associated with numerous changes, including changes in sleep timing, duration, and quality. The circadian timing system interacts with a sleep-wake homeostatic system to regulate human sleep, including sleep timing and structure. Here, we review key features of the human circadian timing system, age-related changes in the circadian timing system, and how those changes may contribute to the observed alterations in sleep. PMID:26568120

  8. Clinicopathologic Features of Pediatric Oligodendrogliomas

    Science.gov (United States)

    Rodriguez, Fausto J.; Tihan, Tarik; Lin, Doris; McDonald, William; Nigro, Janice; Feuerstein, Burt; Jackson, Sadhana; Cohen, Kenneth; Burger, Peter C.

    2015-01-01

    Oligodendrogliomas are an important adult form of diffuse gliomas with a distinctive clinical and genetic profile. Histologically similar tumors occurring rarely in children are incompletely characterized. We studied 50 patients with oligodendrogliomas (median age at diagnosis 8 y, range 7mo to 20 y). Tumors resembling dysembryoplastic neuroepithelial tumors or pilocytic astrocytomas or those having a “mixed” histology were excluded. Tumors at first diagnosis were low grade (n=38) or anaplastic (n=12). Histologic features included uniform round cells with perinuclear halos (100%), secondary structures (predominantly perineuronal satellitosis) (90%), calcifications (46%), and microcysts (44%). Sequential surgical specimens were obtained in 8 low-grade oligodendroglioma patients, with only 1 progressing to anaplasia. Studies for 1p19q performed in 40 cases demonstrated intact 1p19q loci in 29 (73%), 1p19q codeletion in 10 (25%), and 1p deletion with intact 19q in 1 (2%). Except for 2 young patients (3 and 11 y of age), patients with 1p19q codeletion were older than 16 years at diagnosis. Mutant IDH1 (R132H) protein immunohistochemistry was positive in 4 (of 22) (18%) cases, 3 of which also had 1p19q codeletion, whereas 1p19q status was not available on the fourth case. There was a nonsignificant trend for worse overall survival in grade III tumors, but no significant association with age, extent of resection, or 1p19q status. In summary, oligodendrogliomas with classic histology occur in the pediatric population but lack 1p19q codeletion and IDH1 (R132H) mutations in most instances. They are predominantly low grade, recur/clinically progress in a subset, but demonstrate a relatively low frequency of histologic progression. PMID:24805856

  9. Logic based feature detection on incore neutron spectra

    Energy Technology Data Exchange (ETDEWEB)

    Racz, A.; Kiss, S.; Bende-Farkas, S. (Hungarian Academy of Sciences, Budapest (Hungary). Central Research Inst. for Physics)

    1993-04-01

    A general framework for detecting features of incore neutron spectra with a rule-based methodology is presented. As an example, we determine the meaningful peaks in the APSD-s. This work is part of a larger project, aimed at developing a noise diagnostic expert system. (Author).

  10. Features for Exploiting Black-Box Optimization Problem Structure

    DEFF Research Database (Denmark)

    Tierney, Kevin; Malitsky, Yuri; Abell, Tinus

    2013-01-01

    landscape of BBO problems and show how an algorithm portfolio approach can exploit these general, problem indepen- dent features and outperform the utilization of any single minimization search strategy. We test our methodology on data from the GECCO Workshop on BBO Benchmarking 2012, which contains 21...

  11. Feature Selection via Chaotic Antlion Optimization.

    Directory of Open Access Journals (Sweden)

    Hossam M Zawbaa

    Full Text Available Selecting a subset of relevant properties from a large set of features that describe a dataset is a challenging machine learning task. In biology, for instance, the advances in the available technologies enable the generation of a very large number of biomarkers that describe the data. Choosing the more informative markers along with performing a high-accuracy classification over the data can be a daunting task, particularly if the data are high dimensional. An often adopted approach is to formulate the feature selection problem as a biobjective optimization problem, with the aim of maximizing the performance of the data analysis model (the quality of the data training fitting while minimizing the number of features used.We propose an optimization approach for the feature selection problem that considers a "chaotic" version of the antlion optimizer method, a nature-inspired algorithm that mimics the hunting mechanism of antlions in nature. The balance between exploration of the search space and exploitation of the best solutions is a challenge in multi-objective optimization. The exploration/exploitation rate is controlled by the parameter I that limits the random walk range of the ants/prey. This variable is increased iteratively in a quasi-linear manner to decrease the exploration rate as the optimization progresses. The quasi-linear decrease in the variable I may lead to immature convergence in some cases and trapping in local minima in other cases. The chaotic system proposed here attempts to improve the tradeoff between exploration and exploitation. The methodology is evaluated using different chaotic maps on a number of feature selection datasets. To ensure generality, we used ten biological datasets, but we also used other types of data from various sources. The results are compared with the particle swarm optimizer and with genetic algorithm variants for feature selection using a set of quality metrics.

  12. Methodological practicalities in analytical generalization

    DEFF Research Database (Denmark)

    Halkier, Bente

    2011-01-01

    generalization. Theoretically, the argumentation in the article is based on practice theory. The main part of the article describes three different examples of ways of generalizing on the basis of the same qualitative data material. There is a particular focus on describing the methodological strategies......In this article, I argue that the existing literature on qualitative methodologies tend to discuss analytical generalization at a relatively abstract and general theoretical level. It is, however, not particularly straightforward to “translate” such abstract epistemological principles into more...... operative methodological strategies for producing analytical generalizations in research practices. Thus, the aim of the article is to contribute to the discussions among qualitatively working researchers about generalizing by way of exemplifying some of the methodological practicalities in analytical...

  13. Nanotoxicology materials, methodologies, and assessments

    CERN Document Server

    Durán, Nelson; Alves, Oswaldo L; Zucolotto, Valtencir

    2014-01-01

    This book begins with a detailed introduction to engineered nanostructures, followed by a section on methodologies used in research on cytotoxicity and genotoxicity, and concluding with evidence for the cyto- and genotoxicity of specific nanoparticles.

  14. Reflective Methodology: The Beginning Teacher

    Science.gov (United States)

    Templeton, Ronald K.; Siefert, Thomas E.

    1970-01-01

    Offers a variety of specific techniques which will help the beginning teacher to implement reflective methodology and create an inquiry-centered classroom atmosphere, at the same time meeting the many more pressing demands of first-year teaching. (JES)

  15. Methodological exploratory study applied to occupational epidemiology

    Energy Technology Data Exchange (ETDEWEB)

    Carneiro, Janete C.G. Gaburo; Vasques, MOnica Heloisa B.; Fontinele, Ricardo S.; Sordi, Gian Maria A. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)]. E-mail: janetegc@ipen.br

    2007-07-01

    The utilization of epidemiologic methods and techniques has been object of practical experimentation and theoretical-methodological reflection in health planning and programming process. Occupational Epidemiology is the study of the causes and prevention of diseases and injuries from exposition and risks in the work environment. In this context, there is no intention to deplete such a complex theme but to deal with basic concepts of Occupational Epidemiology, presenting the main characteristics of the analysis methods used in epidemiology, as investigate the possible determinants of exposition (chemical, physical and biological agents). For this study, the social-demographic profile of the IPEN-CNEN/SP work force was used. The knowledge of this reference population composition is based on sex, age, educational level, marital status and different occupations, aiming to know the relation between the health aggravating factors and these variables. The methodology used refers to a non-experimental research based on a theoretical methodological practice. The work performed has an exploratory character, aiming a later survey of indicators in the health area in order to analyze possible correlations related to epidemiologic issues. (author)

  16. Methodological exploratory study applied to occupational epidemiology

    International Nuclear Information System (INIS)

    Carneiro, Janete C.G. Gaburo; Vasques, MOnica Heloisa B.; Fontinele, Ricardo S.; Sordi, Gian Maria A.

    2007-01-01

    The utilization of epidemiologic methods and techniques has been object of practical experimentation and theoretical-methodological reflection in health planning and programming process. Occupational Epidemiology is the study of the causes and prevention of diseases and injuries from exposition and risks in the work environment. In this context, there is no intention to deplete such a complex theme but to deal with basic concepts of Occupational Epidemiology, presenting the main characteristics of the analysis methods used in epidemiology, as investigate the possible determinants of exposition (chemical, physical and biological agents). For this study, the social-demographic profile of the IPEN-CNEN/SP work force was used. The knowledge of this reference population composition is based on sex, age, educational level, marital status and different occupations, aiming to know the relation between the health aggravating factors and these variables. The methodology used refers to a non-experimental research based on a theoretical methodological practice. The work performed has an exploratory character, aiming a later survey of indicators in the health area in order to analyze possible correlations related to epidemiologic issues. (author)

  17. Methodological Behaviorism from the Standpoint of a Radical Behaviorist.

    Science.gov (United States)

    Moore, J

    2013-01-01

    Methodological behaviorism is the name for a prescriptive orientation to psychological science. Its first and original feature is that the terms and concepts deployed in psychological theories and explanations should be based on observable stimuli and behavior. I argue that the interpretation of the phrase "based on" has changed over the years because of the influence of operationism. Its second feature, which developed after the first and is prominent in contemporary psychology, is that research should emphasize formal testing of a theory that involves mediating theoretical entities from an nonbehavioral dimension according to the hypothetico-deductive method. I argue that for contemporary methodological behaviorism, explanations of the behavior of both participants and scientists appeal to the mediating entities as mental causes, if only indirectly. In contrast to methodological behaviorism is the radical behaviorism of B. F. Skinner. Unlike methodological behaviorism, radical behaviorism conceives of verbal behavior in terms of an operant process that involves antecedent circumstances and reinforcing consequences, rather than in terms of a nonbehavioral process that involves reference and symbolism. In addition, radical behaviorism recognizes private behavioral events and subscribes to research and explanatory practices that do not include testing hypotheses about supposed mediating entities from another dimension. I conclude that methodological behaviorism is actually closer to mentalism than to Skinner's radical behaviorism.

  18. Methodologies used in Project Management

    OpenAIRE

    UNGUREANU, Adrian; UNGUREANU, Anca

    2014-01-01

    Undoubtedly, a methodology properly defined and strictly followed for project management provides a firm guarantee that the work will be done on time, in budget and according to specifications. A project management methodology in simple terms is a “must-have” to avoid failure and reduce risks, because is one of the critical success factors, such basic skills of the management team. This is the simple way to guide the team through the design and execution phases, processes and tasks throughout...

  19. Methodology for ranking restoration options

    DEFF Research Database (Denmark)

    Jensen, Per Hedemann

    1999-01-01

    techniques as a function of contamination and site characteristics. The project includes analyses of existing remediation methodologies and contaminated sites, and is structured in the following steps:-characterisation of relevant contaminated sites -identication and characterisation of relevant restoration...... techniques -assessment of the radiological impact -development and application of a selection methodology for restoration options -formulation ofgeneric conclusions and development of a manual The project is intended to apply to situations in which sites with nuclear installations have been contaminated...

  20. The trending of aging parameters

    International Nuclear Information System (INIS)

    Gregor, F.E.

    1989-01-01

    During the last 5 years, life extension for nuclear plants has been thoroughly studied and technical as well as economic feasibility has been demonstrated. The next major step is to apply the study results and methodology in a lead plant program to achieve regulatory acceptance. Most components experience a variety of degradation mechanism at differing rates, sometimes acting in synergistic fashion. It is quite obvious that exact quantification in a power plant environment is not practical or simple for most components. This recognition led to the development of an alternative methodology to facilitate management of the aging and degradation process. This methodology is presented

  1. Architectural History and Painting Art at Ajanta: Some Salient Features

    Directory of Open Access Journals (Sweden)

    Manager Singh

    2013-08-01

    Full Text Available The present paper deals with the period of India’s greatest cultural fluorescence, The Golden Age. A lively intellectual debate has been going on among historians and archaeologists on the subject of the chronology of the caves at Ajanta. The study shows addition of many iconographic styles from Ajanta to Bagh caves and vice-versa due to movement of skilled workers and craftsmen between these two Buddhist sites. Many iconographic figures were added / deleted depending on the local condition of rock at both the sites. The art and architecture of these sites reflects India’s great materials culture. The Ajanta paintings are not just a milestone in the history of development of world art but they also convey unique insights about the life of ancient Indians and their culture. This paper outlines some of the architectural features introduced from Ajanta into the other cultures. Furthermore, structural conservation measures and scientific methodology adopted for the preservation of Ajanta murals have also been highlighted.

  2. Mobius syndrome: MRI features

    International Nuclear Information System (INIS)

    Markarian, Maria F.; Villarroel, Gonzalo M.; Nagel, Jorge R.

    2003-01-01

    Purpose: Mobius Syndrome or congenital facial diplegia is associated with paralysis of the lateral gaze movements. This syndrome may include other cranial nerve palsies and be associated to musculoskeletal anomalies. Our objective is to show the MRI findings in Mobius Syndrome. Material and methods: MRI study was performed in 3 patients with clinic diagnosis of Mobius Syndrome. RMI (1.5T); exams included axial FSE (T1 and T2), FLAIR, SE/EPI, GRE/20, sagittal FSE T2 , coronal T1, diffusion, angio MRI and Spectroscopy sequences. Results: The common features of this syndrome found in MRI were: depression or straightening of the floor of the fourth ventricle, brainstem anteroposterior diameter diminution, morphologic alteration of the pons and medulla oblongata and of the hypoglossal nuclei as well as severe micrognathia. Conclusion: The morphologic alterations of Mobius Syndrome can be clearly identified by MRI; this method has proved to be a useful diagnostic examination. (author)

  3. Proctographic features of anismus.

    Science.gov (United States)

    Halligan, S; Bartram, C I; Park, H J; Kamm, M A

    1995-12-01

    To document the proctographic features of anismus at evacuation proctography and determine the optimum radiologic measurements for diagnosis. Twenty-four patients with anismus according to clinical and multiple physiologic criteria were examined with evacuation proctography. Structural and functional measurements were compared with those of a group of 20 asymptomatic subjects. No significant difference between patients and control subjects was found with respect to pelvic descent, rectocele, or any anorectal angle measurement. In patients with anismus, initiation of evacuation was prolonged (median, 9 vs 3 seconds for control subjects; P anismus should be abandoned. Patients with anismus demonstrate delayed initiation of evacuation, which is also prolonged and incomplete. Incomplete evacuation after 30 seconds is highly suggestive of anismus.

  4. Multispectral Image Feature Points

    Directory of Open Access Journals (Sweden)

    Cristhian Aguilera

    2012-09-01

    Full Text Available This paper presents a novel feature point descriptor for the multispectral image case: Far-Infrared and Visible Spectrum images. It allows matching interest points on images of the same scene but acquired in different spectral bands. Initially, points of interest are detected on both images through a SIFT-like based scale space representation. Then, these points are characterized using an Edge Oriented Histogram (EOH descriptor. Finally, points of interest from multispectral images are matched by finding nearest couples using the information from the descriptor. The provided experimental results and comparisons with similar methods show both the validity of the proposed approach as well as the improvements it offers with respect to the current state-of-the-art.

  5. More features, greater connectivity.

    Science.gov (United States)

    Hunt, Sarah

    2015-09-01

    Changes in our political infrastructure, the continuing frailties of our economy, and a stark growth in population, have greatly impacted upon the perceived stability of the NHS. Healthcare teams have had to adapt to these changes, and so too have the technologies upon which they rely to deliver first-class patient care. Here Sarah Hunt, marketing co-ordinator at Aid Call, assesses how the changing healthcare environment has affected one of its fundamental technologies - the nurse call system, argues the case for wireless such systems in terms of what the company claims is greater adaptability to changing needs, and considers the ever-wider range of features and functions available from today's nurse call equipment, particularly via connectivity with both mobile devices, and ancillaries ranging from enuresis sensors to staff attack alert 'badges'.

  6. European Nuclear Features

    International Nuclear Information System (INIS)

    Barre, B.; Gonzalez, E.; Diaz Diaz, J.L.; Jimenez, J.L.; Velarde, G.; Navarro, J.M.; Hittner, D.; Dominguez, M.T.; Bollini, G.; Martin, A.; Suarez, J.; Traini, E.; Lang-Lenton, J.

    2004-01-01

    ''European Nuclear Features - ENF'' is a joint publication of the three specialized technical journals, Nuclear Espana (Spain), Revue General Nucleaire (France), and atw - International Journal of Nuclear Power (Germany). The ENF support the international Europeen exchange of information and news about energy and nuclear power. News items, comments, and scientific and technical contributions will cover important aspects of the field. The second issue of ENF contains contributions about theses topics, among others: Institutional and Political Changes in the EU. - CIEMAT Department of Nuclear Fission: A General Overview. - Inertial Fusion Energy at DENIM. - High Temperature Reactors. European Research Programme. - On Site Assistance to Khmelnitsky NPP 1 and 2 (Ukraine). - Dismantling and Decommissioning of Vandellos I. (orig.)

  7. Abdominal tuberculosis: Imaging features

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Jose M. [Department of Radiology, Hospital de S. Joao, Porto (Portugal)]. E-mail: jmpjesus@yahoo.com; Madureira, Antonio J. [Department of Radiology, Hospital de S. Joao, Porto (Portugal); Vieira, Alberto [Department of Radiology, Hospital de S. Joao, Porto (Portugal); Ramos, Isabel [Department of Radiology, Hospital de S. Joao, Porto (Portugal)

    2005-08-01

    Radiological findings of abdominal tuberculosis can mimic those of many different diseases. A high level of suspicion is required, especially in high-risk population. In this article, we will describe barium studies, ultrasound (US) and computed tomography (CT) findings of abdominal tuberculosis (TB), with emphasis in the latest. We will illustrate CT findings that can help in the diagnosis of abdominal tuberculosis and describe imaging features that differentiate it from other inflammatory and neoplastic diseases, particularly lymphoma and Crohn's disease. As tuberculosis can affect any organ in the abdomen, emphasis is placed to ileocecal involvement, lymphadenopathy, peritonitis and solid organ disease (liver, spleen and pancreas). A positive culture or hystologic analysis of biopsy is still required in many patients for definitive diagnosis. Learning objectives:1.To review the relevant pathophysiology of abdominal tuberculosis. 2.Illustrate CT findings that can help in the diagnosis.

  8. Abdominal tuberculosis: Imaging features

    International Nuclear Information System (INIS)

    Pereira, Jose M.; Madureira, Antonio J.; Vieira, Alberto; Ramos, Isabel

    2005-01-01

    Radiological findings of abdominal tuberculosis can mimic those of many different diseases. A high level of suspicion is required, especially in high-risk population. In this article, we will describe barium studies, ultrasound (US) and computed tomography (CT) findings of abdominal tuberculosis (TB), with emphasis in the latest. We will illustrate CT findings that can help in the diagnosis of abdominal tuberculosis and describe imaging features that differentiate it from other inflammatory and neoplastic diseases, particularly lymphoma and Crohn's disease. As tuberculosis can affect any organ in the abdomen, emphasis is placed to ileocecal involvement, lymphadenopathy, peritonitis and solid organ disease (liver, spleen and pancreas). A positive culture or hystologic analysis of biopsy is still required in many patients for definitive diagnosis. Learning objectives:1.To review the relevant pathophysiology of abdominal tuberculosis. 2.Illustrate CT findings that can help in the diagnosis

  9. [Progress in methodological characteristics of clinical practice guideline for osteoarthritis].

    Science.gov (United States)

    Xing, D; Wang, B; Lin, J H

    2017-06-01

    At present, several clinical practice guidelines for the treatment of osteoarthritis have been developed by institutes or societies. The ultimate purpose of developing clinical practice guidelines is to formulate the process in the treatment of osteoarthritis effectively. However, the methodologies used in developing clinical practice guidelines may place an influence on the transformation and application of that in treating osteoarthritis. The present study summarized the methodological features of individual clinical practice guideline and presented the tools for quality evaluation of clinical practice guideline. The limitations of current osteoarthritis guidelines of China are also indicated. The review article might help relevant institutions improve the quality in developing guide and clinical transformation.

  10. Dependency Parsing with Transformed Feature

    Directory of Open Access Journals (Sweden)

    Fuxiang Wu

    2017-01-01

    Full Text Available Dependency parsing is an important subtask of natural language processing. In this paper, we propose an embedding feature transforming method for graph-based parsing, transform-based parsing, which directly utilizes the inner similarity of the features to extract information from all feature strings including the un-indexed strings and alleviate the feature sparse problem. The model transforms the extracted features to transformed features via applying a feature weight matrix, which consists of similarities between the feature strings. Since the matrix is usually rank-deficient because of similar feature strings, it would influence the strength of constraints. However, it is proven that the duplicate transformed features do not degrade the optimization algorithm: the margin infused relaxed algorithm. Moreover, this problem can be alleviated by reducing the number of the nearest transformed features of a feature. In addition, to further improve the parsing accuracy, a fusion parser is introduced to integrate transformed and original features. Our experiments verify that both transform-based and fusion parser improve the parsing accuracy compared to the corresponding feature-based parser.

  11. Cost analysis methodology of spent fuel storage

    International Nuclear Information System (INIS)

    1994-01-01

    The report deals with the cost analysis of interim spent fuel storage; however, it is not intended either to give a detailed cost analysis or to compare the costs of the different options. This report provides a methodology for calculating the costs of different options for interim storage of the spent fuel produced in the reactor cores. Different technical features and storage options (dry and wet, away from reactor and at reactor) are considered and the factors affecting all options defined. The major cost categories are analysed. Then the net present value of each option is calculated and the levelized cost determined. Finally, a sensitivity analysis is conducted taking into account the uncertainty in the different cost estimates. Examples of current storage practices in some countries are included in the Appendices, with description of the most relevant technical and economic aspects. 16 figs, 14 tabs

  12. A prototype feature system for feature retrieval using relationships

    Science.gov (United States)

    Choi, J.; Usery, E.L.

    2009-01-01

    Using a feature data model, geographic phenomena can be represented effectively by integrating space, theme, and time. This paper extends and implements a feature data model that supports query and visualization of geographic features using their non-spatial and temporal relationships. A prototype feature-oriented geographic information system (FOGIS) is then developed and storage of features named Feature Database is designed. Buildings from the U.S. Marine Corps Base, Camp Lejeune, North Carolina and subways in Chicago, Illinois are used to test the developed system. The results of the applications show the strength of the feature data model and the developed system 'FOGIS' when they utilize non-spatial and temporal relationships in order to retrieve and visualize individual features.

  13. A database of semantic features for chosen concepts (Attested in 8- to 10-year-old Czech pupils

    Directory of Open Access Journals (Sweden)

    Konečná Kristýna

    2017-06-01

    Full Text Available In this paper, a database of semantic features is presented. 104 nominal concepts from 13 semantic categories were described by young Czech school children. They were asked to respond to the question “what is it, what does it mean?” by listing different kinds of properties for concepts in writing. Their responses were broken down into semantic features and the database was prepared using a set of pre-established rules. The method of database design, with an emphasis on the way features were recorded, is described in detail within this article. The data were statistically analysed and interpreted and the results along with database usage methodologies are discussed. The goal of this research is to produce a complex database to be used in future research relating to semantic features and therefore it has been published online for use by the wider academic community. At present, databases have been published based on data gathered from adult English and Czech speakers; however participation in this study was limited specifically to young Czech-speaking children. Thus, this database is characteristically unique as it provides important insight into this specific age and language group’s conceptual knowledge. The research is inspired primarily by research papers concerning semantic feature production obtained from adult English speakers (McRae, de Sa, and Seidenberg, 1997; McRae, Cree, Seidenberg, and McNorgan, 2005; Vinson and Vigliocco, 2008.

  14. Methodologies for Social Life Cycle Assessment

    DEFF Research Database (Denmark)

    Jørgensen, Andreas; Le Bocq, Agathe; Nazakina, Liudmila

    2008-01-01

    Goal, Scope and Background. In recent years several different approaches towards Social Life Cycle Assessment (SLCA) have been developed. The purpose of this review is to compare these approaches in order to highlight methodological differences and general shortcomings. SLCA has several similarit......Goal, Scope and Background. In recent years several different approaches towards Social Life Cycle Assessment (SLCA) have been developed. The purpose of this review is to compare these approaches in order to highlight methodological differences and general shortcomings. SLCA has several...... similarities with other social assessment tools, but in order to limit the review, only claims to address social impacts from an LCA-like framework is considered. Main Features. The review is to a large extent based on conference proceedings and reports of which some are not easily accessible, since very...... stage in the product life cycle. Another very important difference among the proposals is their position towards the use of generic data. Several of the proposals argue that social impacts are connected to the conduct of the company leading to the conclusion that each individual company in the product...

  15. Oral health studies in the 1982 Pelotas (Brazil birth cohort: methodology and principal results at 15 and 24 years of age Estudo longitudinal de saúde bucal na coorte de nascidos vivos em Pelotas, Rio Grande do Sul, Brasil, 1982: aspectos metodológicos e resultados principais aos 15 e 24 anos de idade

    Directory of Open Access Journals (Sweden)

    Karen Glazer Peres

    2011-08-01

    Full Text Available The aim of this study was to describe the methodology and results of oral health studies nested in a birth cohort in Pelotas, Southern Brazil. For the oral health studies a sub-sample (n = 900 was selected from the cohort and dental examinations and interviews were performed at ages 15 (n = 888 and 24 years (n = 720; 81.1%. Data collection included dental outcomes, dental care, oral health behaviors, and use of dental services. Mean DMF-T varied from 5.1 (SD = 3.8 to 5.6 (SD = 4.1 in the study period. The proportion of individuals with at least one filled tooth increased from 51.9% to more than 70%. Individuals who had always been poor used dental services less and had fewer healthy teeth on average than those who had never been poor. Individuals with decreasing or increasing family income trajectories showed intermediate values. An increase was seen in the number of healthy teeth from age 15 to 24 only among those who had never been poor. A history of at least one experience with poverty had a negative impact on oral health in adulthood.Descreveu-se a metodologia e os resultados dos estudos de saúde bucal em uma coorte de nascimentos. Em 1997, uma amostra da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, (n = 900 foi sorteada para o estudo de saúde bucal (15 anos e os mesmos indivíduos foram novamente investigados aos 24 anos. Agravos bucais, cuidados com a saúde bucal e uso de serviços odontológicos foram avaliados. Participaram do estudo 888 adolescentes aos 15 anos e 720 (81,1% aos 24. O índice CPO-D médio variou de 5,1 (DP = 3,8 a 5,6 (DP = 4,1 no período. Ter pelo menos um dente restaurado passou de 51,9% aos 15 anos para mais de 70% aos 24. A proporção do uso de serviços e a média de dentes saudáveis foram menores dentre os sempre pobres quando comparados àqueles nunca pobres. Indivíduos com trajetórias econômicas descendente ou ascendente tiveram valores intermediários. Aumento de dentes saudáveis dos 15

  16. Mikhail Geraskov (1874-1957 Methodological Concepts of Learning Physics.

    Directory of Open Access Journals (Sweden)

    Mariyana Ilieva

    2014-02-01

    Full Text Available Mikhail Geraskov is a distinguished Bulgarian educator from the first half of the twentieth century, who developed the scientific foundations of didactics and methodology of training. His work contributed a lot to the development of the Bulgarian pedagogy. The subject of scientific research is didactical conceptions and methodological conceptions of learning. The aim of the research paper is to presents his ideas about particular methods of teaching Physics for high school. Geraskov assumes direct correlation between didactics and methodology. This paper focuses on his ideas about design, technology and methodological requirements for lessons of Physics. He believes that the appropriate methods are determined by the curriculum, set of educational goals and age characteristics, and capabilities of adolescents. In his methodical recommendations he focuses on teaching methods and forms that provoke students’ activity. Comparative analysis with publications on the issues set for development of the Bulgarian pedagogic science and the actuality in the modern education system.

  17. Application of a methodology for the development and validation of reliable process control software

    International Nuclear Information System (INIS)

    Ramamoorthy, C.V.; Mok, Y.R.; Bastani, F.B.; Chin, G.

    1980-01-01

    The necessity of a good methodology for the development of reliable software, especially with respect to the final software validation and testing activities, is discussed. A formal specification development and validation methodology is proposed. This methodology has been applied to the development and validation of a pilot software, incorporating typical features of critical software for nuclear power plants safety protection. The main features of the approach include the use of a formal specification language and the independent development of two sets of specifications. 1 ref

  18. New concept of age(ing: Prospective age

    Directory of Open Access Journals (Sweden)

    Devedžić Mirjana

    2012-01-01

    Full Text Available While the last century was the century of world population growth, according to demographers, the XXI century will be century of population aging. Statistics undoubtedly show that number of elderly will continue it’s growth in the future. If old age is seen as period of life with reduced physical and mental capabilities and increased disability, and demographic aging as increase of dependent population, trends are quite disturbing, at least in certain societal segments. In developed countries, this population category is no longer treated as passive or as a "burden of society" and efforts are made for better social inclusion of older people. In contrast to growing interest in this phenomenon, the concepts that define the aging of the population remained stagnant. The aim of this paper is to introduce into domestic literature the term "prospective age" as a dynamic category which is more affected with socio-historical conditions, not only with biological as traditional definition of aging suggested. Papers written by Sanderson and Scherbov offer new methodological options for study of population aging, because it takes into account the biometric rather than chronological approach. Calculation of prospective years is a simple operation that requires pair of the same number of remained life expectancy from life tables for two different periods (the year of concern is index, and the one we are comparing with is standard year, so that phrase "40s is the new 30s" or "70s the new 60s" gets scientific foundation. Average remaining years of life represent a realistic indicator suggesting increased capacity, activity and vitality of individuals, which is due to accepted demographic parameters still considered old. „Prospective threshold“ is defined as the age when life expectancy falls below 15 years (it is subjective choice made by Sanderson and Scherbov, which is also used in this paper and during the elaboration of these ideas three demographic

  19. Managerial Methodology in Public Institutions

    Directory of Open Access Journals (Sweden)

    Ion VERBONCU

    2010-10-01

    Full Text Available One of the most important ways of making public institutions more efficient is by applying managerial methodology, embodied in the promotion of management tools, modern and sophisticated methodologies, as well as operation of designing/redesigning and maintenance of the management process and its components. Their implementation abides the imprint of constructive and functional particularities of public institutions, decentralized and devolved, and, of course, the managers’ expertise of these organizations. Managerial methodology is addressed through three important instruments diagnosis, management by objectives and scoreboard. Its presence in the performance management process should be mandatory, given the favorable influence on the management and economic performance and the degree of scholastic approach of the managers’ performance.

  20. Blanket safety by GEMSAFE methodology

    International Nuclear Information System (INIS)

    Sawada, Tetsuo; Saito, Masaki

    2001-01-01

    General Methodology of Safety Analysis and Evaluation for Fusion Energy Systems (GEMSAFE) has been applied to a number of fusion system designs, such as R-tokamak, Fusion Experimental Reactor (FER), and the International Thermonuclear Experimental Reactor (ITER) designs in the both stages of Conceptual Design Activities (CDA) and Engineering Design Activities (EDA). Though the major objective of GEMSAFE is to reasonably select design basis events (DBEs) it is also useful to elucidate related safety functions as well as requirements to ensure its safety. In this paper, we apply the methodology to fusion systems with future tritium breeding blankets and make clear which points of the system should be of concern from safety ensuring point of view. In this context, we have obtained five DBEs that are related to the blanket system. We have also clarified the safety functions required to prevent accident propagations initiated by those blanket-specific DBEs. The outline of the methodology is also reviewed. (author)

  1. The NLC Software Requirements Methodology

    Energy Technology Data Exchange (ETDEWEB)

    Shoaee, Hamid

    2002-08-20

    We describe the software requirements and development methodology developed for the NLC control system. Given the longevity of that project, and the likely geographical distribution of the collaborating engineers, the planned requirements management process is somewhat more formal than the norm in high energy physics projects. The short term goals of the requirements process are to accurately estimate costs, to decompose the problem, and to determine likely technologies. The long term goal is to enable a smooth transition from high level functional requirements to specific subsystem and component requirements for individual programmers, and to support distributed development. The methodology covers both ends of that life cycle. It covers both the analytical and documentary tools for software engineering, and project management support. This paper introduces the methodology, which is fully described in [1].

  2. NAD+ in Aging

    DEFF Research Database (Denmark)

    Fang, Evandro F.; Lautrup, Sofie; Hou, Yujun

    2017-01-01

    The coenzyme NAD+ is critical in cellular bioenergetics and adaptive stress responses. Its depletion has emerged as a fundamental feature of aging that may predispose to a wide range of chronic diseases. Maintenance of NAD+ levels is important for cells with high energy demands and for proficient...... neuronal function. NAD+ depletion is detected in major neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, cardiovascular disease and muscle atrophy. Emerging evidence suggests that NAD+ decrements occur in various tissues during aging, and that physiological and pharmacological...... interventions bolstering cellular NAD+ levels might retard aspects of aging and forestall some age-related diseases. Here, we discuss aspects of NAD+ biosynthesis, together with putative mechanisms of NAD+ action against aging, including recent preclinical and clinical trials. Recent discoveries have...

  3. Radiographic Features of Acute Patellar Tendon Rupture.

    Science.gov (United States)

    Fazal, Muhammad Ali; Moonot, Pradeep; Haddad, Fares

    2015-11-01

    The purpose of our study was to assess soft tissue features of acute patellar tendon rupture on lateral knee radiograph that would facilitate early diagnosis. The participants were divided into two groups of 35 patients each. There were 28 men and seven women with a mean age of 46 years in the control group and 26 men and nine women with a mean age of 47 years in the rupture group. The lateral knee radiograph of each patient was evaluated for Insall-Salvati ratio for patella alta, increased density of the infrapatellar fat pad, appearance of the soft tissue margin of the patellar tendon and bony avulsions. In the rupture group there were three consistent soft tissue radiographic features in addition to patellar alta. These were increased density of infrapatellar fat pad; loss of sharp, well-defined linear margins of the patellar tendon and angulated wavy margin of the patellar tendon while in the control group these features were not observed. The soft tissue radiographic features described in the rupture group are consistent and reliable. When coupled with careful clinical assessment, these will aid in early diagnosis and further imaging will be seldom required. © 2015 Chinese Orthopaedic Association and Wiley Publishing Asia Pty Ltd.

  4. Analysis of computed tomography features of fungal sinusitis and ...

    African Journals Online (AJOL)

    CT) features of fungal sinusitis and to correlate them with nasal endoscopy and histopathological findings. Materials and Methods: Our study included 16 patients of either sex and any age group who presented in the otorhinolaryngology clinic at ...

  5. Feature Inference Learning and Eyetracking

    Science.gov (United States)

    Rehder, Bob; Colner, Robert M.; Hoffman, Aaron B.

    2009-01-01

    Besides traditional supervised classification learning, people can learn categories by inferring the missing features of category members. It has been proposed that feature inference learning promotes learning a category's internal structure (e.g., its typical features and interfeature correlations) whereas classification promotes the learning of…

  6. Pharmacological features of osthole

    Directory of Open Access Journals (Sweden)

    Agata Jarząb

    2017-05-01

    Full Text Available Coumarins are a group of naturally occurring compounds common in the plant world. These substances and their derivatives exhibit a broad range of biological activities.One of the naturally occurring coumarins is osthole, which can most frequently be found in plants of the Apiaceae family. Cnidium monnieri (L. Cusson ex Juss. Angelica pubescens Maxim. and Peucedanum ostruthium (L.. It has anti-proliferative, anti-inflammatory, anti-convulsant, and antiallergic properties; apart from that, inhibition of platelet aggregation has also been proved. The impact of osthole on bone metabolism has been demonstrated; also its hepatoprotective and neuroprotective properties have been confirmed. The inhibitory effect of this metokcompound on the development of neurodegenerative diseases has been proved in experimental models. Anticancer features of osthole have been also demonstrated both in vitro on different cell lines, and in vivo using animals xenografts. Osthole inhibited proliferation, motility and invasiveness of tumor cells, which may be associated with the induction of apoptosis and cell cycle slowdown. The exact molecular mechanism of osthole anti-cancer mode of action has not been fully elucidated. A synergistic effect of osthole with other anti-tumor substances has been also reported. Modification of its chemical structure led to the synthesis of many derivatives with significant anticancer effects.To sum up, osthole is an interesting therapeutic option, due to both its direct effect on tumor cells, as well as its neuroprotective or anti-inflammatory properties. Thus, there is a chance to use osthole or its synthetic derivatives in the treatment of cancer.

  7. Slim Battery Modelling Features

    Science.gov (United States)

    Borthomieu, Y.; Prevot, D.

    2011-10-01

    Saft has developed a life prediction model for VES and MPS cells and batteries. The Saft Li-ion Model (SLIM) is a macroscopic electrochemical model based on energy (global at cell level). The main purpose is to predict the battery performances during the life for GEO, MEO and LEO missions. This model is based on electrochemical characteristics such as Energy, Capacity, EMF, Internal resistance, end of charge voltage. It uses fading and calendar law effects on energy and internal impedance vs. time, temperature, End of Charge voltage. Based on the mission profile, satellite power system characteristics, the model proposes the various battery configurations. For each configuration, the model gives the battery performances using mission figures and profiles: power, duration, DOD, end of charge voltages, temperatures during eclipses and solstices, thermal dissipations and cell failures. For the GEO/MEO missions, eclipse and solstice periods can include specific profile such as plasmic propulsion fires and specific balancing operations. For LEO missions, the model is able to simulate high power peaks to predict radar pulses. Saft's main customers have been using the SLIM model available in house for two years. The purpose is to have the satellite builder power engineers able to perform by themselves in the battery pre-dimensioning activities their own battery simulations. The simulations can be shared with Saft engineers to refine the power system designs. This model has been correlated with existing life and calendar tests performed on all the VES and MPS cells. In comparing with more than 10 year lasting life tests, the accuracy of the model from a voltage point of view is less than 10 mV at end Of Life. In addition, thethe comparison with in-orbit data has been also done. b This paper will present the main features of the SLIM software and outputs comparison with real life tests. b0

  8. Methodology, theoretical framework and scholarly significance: An ...

    African Journals Online (AJOL)

    Methodology, theoretical framework and scholarly significance: An overview ... AFRICAN JOURNALS ONLINE (AJOL) · Journals · Advanced Search ... Keywords: Legal Research, Methodology, Theory, Pedagogy, Legal Training, Scholarship ...

  9. Feature-based RNN target recognition

    Science.gov (United States)

    Bakircioglu, Hakan; Gelenbe, Erol

    1998-09-01

    Detection and recognition of target signatures in sensory data obtained by synthetic aperture radar (SAR), forward- looking infrared, or laser radar, have received considerable attention in the literature. In this paper, we propose a feature based target classification methodology to detect and classify targets in cluttered SAR images, that makes use of selective signature data from sensory data, together with a neural network technique which uses a set of trained networks based on the Random Neural Network (RNN) model (Gelenbe 89, 90, 91, 93) which is trained to act as a matched filter. We propose and investigate radial features of target shapes that are invariant to rotation, translation, and scale, to characterize target and clutter signatures. These features are then used to train a set of learning RNNs which can be used to detect targets within clutter with high accuracy, and to classify the targets or man-made objects from natural clutter. Experimental data from SAR imagery is used to illustrate and validate the proposed method, and to calculate Receiver Operating Characteristics which illustrate the performance of the proposed algorithm.

  10. Multiscale wavelet representations for mammographic feature analysis

    Science.gov (United States)

    Laine, Andrew F.; Song, Shuwu

    1992-12-01

    This paper introduces a novel approach for accomplishing mammographic feature analysis through multiresolution representations. We show that efficient (nonredundant) representations may be identified from digital mammography and used to enhance specific mammographic features within a continuum of scale space. The multiresolution decomposition of wavelet transforms provides a natural hierarchy in which to embed an interactive paradigm for accomplishing scale space feature analysis. Choosing wavelets (or analyzing functions) that are simultaneously localized in both space and frequency, results in a powerful methodology for image analysis. Multiresolution and orientation selectivity, known biological mechanisms in primate vision, are ingrained in wavelet representations and inspire the techniques presented in this paper. Our approach includes local analysis of complete multiscale representations. Mammograms are reconstructed from wavelet coefficients, enhanced by linear, exponential and constant weight functions localized in scale space. By improving the visualization of breast pathology we can improve the changes of early detection of breast cancers (improve quality) while requiring less time to evaluate mammograms for most patients (lower costs).

  11. Methodological Guidelines for Advertising Research

    DEFF Research Database (Denmark)

    Rossiter, John R.; Percy, Larry

    2017-01-01

    In this article, highly experienced advertising academics and advertising research consultants John R. Rossiter and Larry Percy present and discuss what they believe to be the seven most important methodological guidelines that need to be implemented to improve the practice of advertising research....... Their focus is on methodology, defined as first choosing a suitable theoretical framework to guide the research study and then identifying the advertising responses that need to be studied. Measurement of those responses is covered elsewhere in this special issue in the article by Bergkvist and Langner. Most...

  12. Acoustic emission methodology and application

    CERN Document Server

    Nazarchuk, Zinoviy; Serhiyenko, Oleh

    2017-01-01

    This monograph analyses in detail the physical aspects of the elastic waves radiation during deformation or fracture of materials. I presents the  methodological bases for the practical use of acoustic emission device, and describes the results of theoretical and experimental researches of evaluation of the crack growth resistance of materials, selection of the useful AE signals. The efficiency of this methodology is shown through the diagnostics of various-purpose industrial objects. The authors obtain results of experimental researches with the help of the new methods and facilities.

  13. An LWR design decision Methodology

    International Nuclear Information System (INIS)

    Leahy, T.J.; Rees, D.C.; Young, J.

    1982-01-01

    While all parties involved in nuclear plant regulation endeavor to make decisions which optimize the considerations of plant safety and financial impacts, these decisions are generally made without the benefit of a systematic and rigorous approach to the questions confronting the decision makers. A Design Decision Methodology has been developed which provides such a systematic approach. By employing this methodology, which makes use of currently accepted probabilistic risk assessment techniques and cost estimation, informed decisions may be made against a background of comparisons between the relative levels of safety and costs associated with various design alternatives

  14. Qualitative methodology in developmental psychology

    DEFF Research Database (Denmark)

    Demuth, Carolin; Mey, Günter

    2015-01-01

    Qualitative methodology presently is gaining increasing recognition in developmental psychology. Although the founders of developmental psychology to a large extent already used qualitative procedures, the field was long dominated by a (post) positivistic quantitative paradigm. The increasing rec...... in qualitative research offers a promising avenue to advance the field in this direction.......Qualitative methodology presently is gaining increasing recognition in developmental psychology. Although the founders of developmental psychology to a large extent already used qualitative procedures, the field was long dominated by a (post) positivistic quantitative paradigm. The increasing...

  15. Qualitative Methodology in Unfamiliar Cultures

    DEFF Research Database (Denmark)

    Svensson, Christian Franklin

    2014-01-01

    on a qualitative methodology, conscious reflection on research design and objectivity is important when doing fieldwork. This case study discusses such reflections. Emphasis throughout is given to applied qualitative methodology and its contributions to the social sciences, in particular having to do......This case study discusses qualitative fieldwork in Malaysia. The trends in higher education led to investigating how and why young Indians and Chinese in Malaysia are using the university to pursue a life strategy. Given the importance of field context in designing and analysing research based...

  16. Observational methodology in sport sciences

    Directory of Open Access Journals (Sweden)

    M. Teresa Anguera

    2013-11-01

    Full Text Available This paper reviews the conceptual framework, the key literature and the methods (observation tools, such as category systems and field formats, and coding software, etc. that should be followed when conducting research from the perspective of observational methodology. The observational designs used by the authors’ research group over the last twenty years are discussed, and the procedures for analysing data and assessing their quality are described. Mention is also made of the latest methodological trends in this field, such as the use of mixed methods.

  17. Reflections on Design Methodology Research

    DEFF Research Database (Denmark)

    2011-01-01

    We shall reflect on the results of Design Methodology research and their impact on design practice. In the past 50 years the number of researchers in the field has expanded enormously – as has the number of publications. During the same period design practice and its products have changed...... and produced are also now far more complex and distributed, putting designers under ever increasing pressure. We shall address the question: Are the results of Design Methodology research appropriate and are they delivering the expected results in design practice? In our attempt to answer this question we...

  18. Ghost Hunting as a Means to Illustrate Scientific Methodology and Enhance Critical Thinking

    Science.gov (United States)

    Rockwell, Steven C.

    2012-01-01

    The increasing popularity of television shows featuring paranormal investigations has led to a renewed enthusiasm in ghost hunting activities, and belief in the paranormal in general. These shows typically feature a group of investigators who, while claiming to utilize proper scientifically correct methodologies, violate many core scientific…

  19. BIOLOGICAL FEATURES OF TARAN (RUTILUS HECKELII OF THE DNIEPER-BUG ESTUARY SYSTEM

    Directory of Open Access Journals (Sweden)

    K. Geina

    2016-03-01

    Full Text Available Purpose. To analyze morphological variability and basic biological features of the modern stock of taran of the Dnieper-Bug estuary system in the conditions of the transformed Dnieper flow. Methodology. Morphological variability was determined based on the comparison of morphological features of roach Rutilus rutilus (Linnaeus, 1758 of the Kakhovka reservoir and semi-migratory taran Rutilus rutilus heckelii (Nordmann, 1840 of the Dnieper-Bug estuary system. As a main criterion of the evaluation of the taran stock biological state, we used age, sex structure, growth characteristics, fecundity and condition factor. Fish sampling was carried out at stationary monitoring-observation stations of the Institute of Fisheries NAAS of Ukraine. Field and cameral processing of the collected materials were performed based on conventional methods and guidelines. Findings. Morphological variability analysis demonstrated significant differences between Dnieper and Bug taran. The highest differences were observed for antroventral distance (td=11.19. Significant differences were also observed for antenanal and ventroanal distances td=4.05-4.14. No significant differences were found for meristic features. There were also significant differences between Dnieper-Bug taran and Kakhovka reservoir roach, which had formed a resident form after regulating the Dnieper River flow. Kakhovka reservoir roach is more deep-bodied with Н=32.79%, t-test value was 5.65. Pelvic fins were more shifted to the caudal fin (td=5.28 that resulted in significant difference (p<0.05 in ventroanal distance (td=4.26. Taran also had somewhat smaller length of the anal fin base (td=4.73 but its height was higher – td=5.78. The main peculiarity of the current biological state of taran stock is the domination of young age groups. The small number of fish in the boundary groups of the age series right wing with relative stability of growth features indicate on intensive pressure on the

  20. New quickest transient detection methodology. Nuclear engineering applications

    International Nuclear Information System (INIS)

    Wang, Xin; Jevremovic, Tatjana; Tsoukalas, Lefteri H.

    2003-01-01

    A new intelligent systems methodology for quickest online transient detection is presented. Based on information that includes, but is not limited to, statistical features, energy of frequency components and wavelet coefficients, the new methodology decides whether a transient has emerged. A fuzzy system makes the final decision, the membership functions of which are obtained by artificial neural networks and adjusted in an online manner. Comparisons are performed with conventional methods for transient detection using simulated and plant data. The proposed methodology could be useful in power plant operations, diagnostic and maintenance activities. It is also considered as a design tool for quick design modifications in a virtual design environment aimed at next generation University Research and Training Reactors (URTRs). (The virtual design environment is pursued as part of the Big-10 Consortium sponsored by the new Innovations in Nuclear Infrastructure and Education (INIE) program sponsored by the US Department of Energy.) (author)

  1. Revised INPRO Methodology in the Area of Proliferation Resistance

    International Nuclear Information System (INIS)

    Park, J.H.; Lee, Y.D.; Yang, M.S.; Kim, J.K.; Haas, E.; Depisch, F.

    2008-01-01

    The official INPRO User Manual in the area of proliferation resistance is being processed for the evaluation of innovative nuclear energy systems. Proliferation resistance is one of the goals to be satisfied for future nuclear energy systems in INPRO. The features of currently updated and released INPRO methodology were introduced on basic principles, user requirements and indicators. The criteria for an acceptance limit were specified. The DUPIC fuel cycle was evaluated based on the updated INPRO methodology for the applicability of the INPRO User Manual. However, the INPRO methodology has some difficulty in quantifying the multiplicity and robustness as well as the total cost to improve proliferation resistance. Moreover, the integration method for the evaluation results still needs to be improved.

  2. Millennial Expectations and Constructivist Methodologies: Their Corresponding Characteristics and Alignment

    Science.gov (United States)

    Carter, Timothy L.

    2008-01-01

    In recent years, much emphasis has been placed on constructivist methodologies and their potential benefit for learners of various ages (Brandt & Perkins, 2000; Brooks, 1990). Although certain aspects of the constructivist paradigm have replaced several aspects of the behaviorist paradigm for a large contingency of stakeholders (particularly,…

  3. Personality Assessment of Global Talent: Conceptual and Methodological Issues

    Science.gov (United States)

    van de Vijver, Fons J. R.

    2008-01-01

    The recruitment of managers who will operate in a culturally heterogeneous context (as expatriate managers, managers in a global company, or managers of a multicultural workforce) is increasingly important in an age of globalization. This article describes conceptual and methodological issues in the assessment of such managers, notably in the…

  4. Remember some or remember all? Ageing and strategy effects in visual working memory.

    Science.gov (United States)

    Atkinson, Amy L; Baddeley, Alan D; Allen, Richard J

    2017-08-16

    Recent research (Bengson & Luck, 2015) has indicated that visual working memory capacity for unidimensional items might be boosted by focusing on all presented items, as opposed to a subset of them. However, it is not clear whether the same outcomes would be observed if more complex items were used which require feature binding, a potentially more demanding task. The current experiments therefore examined the effects of encoding strategy using multidimensional items in tasks that required feature binding. Effects were explored across a range of different age groups (Experiment 1) and task conditions (Experiment 2). In both experiments, participants performed significantly better when focusing on a subset of items, regardless of age or methodological variations, suggesting this is the optimal strategy to employ when several multidimensional items are presented and binding is required. Implications for task interpretation and visual working memory function are discussed.

  5. Selective methodology of population dynamics for optimizing a multiobjective environment of job shop production

    Directory of Open Access Journals (Sweden)

    Santiago Ruiz

    2015-01-01

    Full Text Available This paper develops a methodology based on population genetics to improve the performance of two or more variables in job shop production systems. The methodology applies a genetic algorithm with special features in the individual selection when they pass from generation to generation. In comparison with the FIFO method, the proposed methodology showed better results in the variables makespan, idle time and energy cost. When compared with NSGA II, the methodology did not showed relevant differences in makespan and idle time; however better performance was obtained in energy cost and, especially, in the number of required iterations to get the optimal makespan.

  6. THEORETICAL AND METHODOLOGICAL APPROACHES TO REGIONAL COMPETITION INVESTIGATION

    Directory of Open Access Journals (Sweden)

    A.I. Tatarkin

    2006-03-01

    Full Text Available The article is dedicated to theoretical-methodological issues of regional economy competitiveness investigation. Economic essence of regional competitiveness is analyzed, its definition is given. The factors that determine relations of competition on medium and macrolevels are proved. The basic differences between world-economical and inter-regional communications are formulated. The specific features of globalization processes as form of competitive struggle are considered.

  7. [Methodologic inconsistency in anamnesis education at medical schools].

    Science.gov (United States)

    Zago, M A

    1989-01-01

    Some relevant points of the process of obtaining the medical anamnesis and physical examination, and the formulation of diagnostic hypotheses are analyzed. The main methodological features include: preponderance of qualitative data, absence of preselected hypotheses, direct involvement of the observer (physician) with the data source (patient), and selection of hypotheses and changes of the patient during the process. Thus, diagnostic investigation does not follow the paradigm of quantitative scientific method, rooted on the logic positivism, which dominates medical research and education.

  8. Aging changes in the male reproductive system

    Science.gov (United States)

    ... ency/article/004017.htm Aging changes in the male reproductive system To use the sharing features on this page, please enable JavaScript. Aging changes in the male reproductive system may include changes in testicular tissue, sperm production, ...

  9. Risk-Informed Assessment Methodology Development and Application

    International Nuclear Information System (INIS)

    Sung Goo Chi; Seok Jeong Park; Chul Jin Choi; Ritterbusch, S.E.; Jacob, M.C.

    2002-01-01

    Westinghouse Electric Company (WEC) has been working with Korea Power Engineering Company (KOPEC) on a US Department of Energy (DOE) sponsored Nuclear Energy Research Initiative (NERI) project through a collaborative agreement established for the domestic NERI program. The project deals with Risk-Informed Assessment (RIA) of regulatory and design requirements of future nuclear power plants. An objective of the RIA project is to develop a risk-informed design process, which focuses on identifying and incorporating advanced features into future nuclear power plants (NPPs) that would meet risk goals in a cost-effective manner. The RIA design methodology is proposed to accomplish this objective. This paper discusses the development of this methodology and demonstrates its application in the design of plant systems for future NPPs. Advanced conceptual plant systems consisting of an advanced Emergency Core Cooling System (ECCS) and Emergency Feedwater System (EFWS) for a NPP were developed and the risk-informed design process was exercised to demonstrate the viability and feasibility of the RIA design methodology. Best estimate Loss-of-Coolant Accident (LOCA) analyses were performed to validate the PSA success criteria for the NPP. The results of the analyses show that the PSA success criteria can be met using the advanced conceptual systems and that the RIA design methodology is a viable and appropriate means of designing key features of risk-significant NPP systems. (authors)

  10. Methodologic frontiers in environmental epidemiology.

    OpenAIRE

    Rothman, K J

    1993-01-01

    Environmental epidemiology comprises the epidemiologic study of those environmental factors that are outside the immediate control of the individual. Exposures of interest to environmental epidemiologists include air pollution, water pollution, occupational exposure to physical and chemical agents, as well as psychosocial elements of environmental concern. The main methodologic problem in environmental epidemiology is exposure assessment, a problem that extends through all of epidemiologic re...

  11. IMSF: Infinite Methodology Set Framework

    Science.gov (United States)

    Ota, Martin; Jelínek, Ivan

    Software development is usually an integration task in enterprise environment - few software applications work autonomously now. It is usually a collaboration of heterogeneous and unstable teams. One serious problem is lack of resources, a popular result being outsourcing, ‘body shopping’, and indirectly team and team member fluctuation. Outsourced sub-deliveries easily become black boxes with no clear development method used, which has a negative impact on supportability. Such environments then often face the problems of quality assurance and enterprise know-how management. The used methodology is one of the key factors. Each methodology was created as a generalization of a number of solved projects, and each methodology is thus more or less connected with a set of task types. When the task type is not suitable, it causes problems that usually result in an undocumented ad-hoc solution. This was the motivation behind formalizing a simple process for collaborative software engineering. Infinite Methodology Set Framework (IMSF) defines the ICT business process of adaptive use of methods for classified types of tasks. The article introduces IMSF and briefly comments its meta-model.

  12. Environmental Zoning: Some methodological implications

    NARCIS (Netherlands)

    Ike, Paul; Voogd, Henk

    1991-01-01

    The purpose of this article is to discuss some methodological problems of environmental zoning. The principle of environmental zoning will be elaborated. In addition an overview is given of a number of approaches that have been followed in practice to arrive at an integral judgement. Finally some

  13. A methodology for string resolution

    International Nuclear Information System (INIS)

    Karonis, N.T.

    1992-11-01

    In this paper we present a methodology, not a tool. We present this methodology with the intent that it be adopted, on a case by case basis, by each of the existing tools in EPICS. In presenting this methodology, we describe each of its two components in detail and conclude with an example depicting how the methodology can be used across a pair of tools. The task of any control system is to provide access to the various components of the machine being controlled, for example, the Advanced Photon Source (APS). By access, we mean the ability to monitor the machine's status (reading) as well as the ability to explicitly change its status (writing). The Experimental Physics and Industrial Control System (EPICS) is a set of tools, designed to act in concert, that allows one to construct a control system. EPICS provides the ability to construct a control system that allows reading and writing access to the machine. It does this through the notion of databases. Each of the components of the APS that is accessed by the control system is represented in EPICS by a set of named database records. Once this abstraction is made, from physical device to named database records, the process of monitoring and changing the state of that device becomes the simple process of reading and writing information from and to its associated named records

  14. Counting stem cells : methodological constraints

    NARCIS (Netherlands)

    Bystrykh, Leonid V.; Verovskaya, Evgenia; Zwart, Erik; Broekhuis, Mathilde; de Haan, Gerald

    The number of stem cells contributing to hematopoiesis has been a matter of debate. Many studies use retroviral tagging of stem cells to measure clonal contribution. Here we argue that methodological factors can impact such clonal analyses. Whereas early studies had low resolution, leading to

  15. Test reactor risk assessment methodology

    International Nuclear Information System (INIS)

    Jennings, R.H.; Rawlins, J.K.; Stewart, M.E.

    1976-04-01

    A methodology has been developed for the identification of accident initiating events and the fault modeling of systems, including common mode identification, as these methods are applied in overall test reactor risk assessment. The methods are exemplified by a determination of risks to a loss of primary coolant flow in the Engineering Test Reactor

  16. 16 Offsetting deficit conceptualisations: methodological ...

    African Journals Online (AJOL)

    uses the concepts of literacy practices and knowledge recontextualisation to ... 1996, 2000) theory of 'knowledge recontextualisation' in the development of curricula .... cognitive, social and cultural abilities needed to fit in and thrive in the HE learning .... this argument, that a methodology and analytic framework that seeks to ...

  17. Methodology for the case studies

    NARCIS (Netherlands)

    Smits, M.J.W.; Woltjer, G.B.

    2017-01-01

    This document is about the methodology and selection of the case studies. It is meant as a guideline for the case studies, and together with the other reports in this work package can be a source of inform ation for policy officers, interest groups and researchers evaluating or performing impact

  18. Safety at Work : Research Methodology

    NARCIS (Netherlands)

    Beurden, van K. (Karin); Boer, de J. (Johannes); Brinks, G. (Ger); Goering-Zaburnenko, T. (Tatiana); Houten, van Y. (Ynze); Teeuw, W. (Wouter)

    2012-01-01

    In this document, we provide the methodological background for the Safety atWork project. This document combines several project deliverables as defined inthe overall project plan: validation techniques and methods (D5.1.1), performanceindicators for safety at work (D5.1.2), personal protection

  19. Cancer and aging

    DEFF Research Database (Denmark)

    Pedersen, Jacob K; Engholm, Gerda; Skytthe, Axel

    2016-01-01

    Epidemiological cancer data shed light on key questions within basic science, clinical medicine and public health. For decades, Denmark has had linkable health registers that contain individual level data on the entire population with virtually complete follow-up. This has enabled high quality...... studies of cancer epidemiology and minimized the challenges often faced in many countries, such as uncertain identification of the study base, age misreporting, and low validity of the cancer diagnoses. However, methodological challenges still remain to be addressed, especially in cancer epidemiology...... studies among the elderly and the oldest-old. For example, a characteristic pattern for many cancer types is that the incidence increases up to a maximum at about ages 75-90 years and is then followed by a decline or a leveling off at the oldest ages. It has been suggested that the oldest individuals may...

  20. Logic based feature detection on incore neutron spectra

    International Nuclear Information System (INIS)

    Bende-Farkas, S.; Kiss, S.; Racz, A.

    1992-09-01

    A methodology is proposed to investigate neutron spectra in such a way which is similar to human thinking. The goal was to save experts from tedious, mechanical tasks of browsing a large amount of signals in order to recognize changes in the underlying mechanisms. The general framework for detecting features of incore neutron spectra with a rulebased methodology is presented. As an example, the meaningful peaks in the APSDs are determined. This method is a part of a wider project to develop a noise diagnostic expert system. (R.P.) 6 refs.; 6 figs.; 1 tab