WorldWideScience

Sample records for methodological challenges related

  1. Methodological challenges and lessons learned

    DEFF Research Database (Denmark)

    Nielsen, Poul Erik; Gustafsson, Jessica

    2017-01-01

    Taking as point of departure three recently conducted empirical studies, the aim of this article is to theoretically and empirically discuss methodological challenges studying the interrelations between media and social reality and to critically reflect on the methodologies used in the studies....... By deconstructing the studies, the article draws attention to the fact that different methods are able to grasp different elements of social reality. Moreover, by analysing the power relations at play, the article demonstrated that the interplay between interviewer and interviewee, and how both parties fit...... into present power structures, greatly influence the narratives that are co-produced during interviews. The article thus concludes that in order to fully understand complex phenomena it is not just enough to use a mixture of methods, the makeup of the research team is also imperative, as a diverse team...

  2. Investigating the association between medication adherence and health-related quality of life in COPD : Methodological challenges when using a proxy measure of adherence

    NARCIS (Netherlands)

    Boland, Melinde R. S.; van Boven, Job F. M.; Kruis, Annemarije L.; Chavannes, Niels H.; van der Molen, Thys; Goossens, Lucas M. A.; Rutten-van Molken, Maureen P. M. H.

    Background: The association between non-adherence to medication and health-related quality-of-life (HRQoL) in Chronic Obstructive Pulmonary Disease (COPD) remains poorly understood. Different ways to deal with methodological challenges to estimate this association have probably contributed to

  3. Decision making about healthcare-related tests and diagnostic test strategies. Paper 2: a review of methodological and practical challenges.

    Science.gov (United States)

    Mustafa, Reem A; Wiercioch, Wojtek; Cheung, Adrienne; Prediger, Barbara; Brozek, Jan; Bossuyt, Patrick; Garg, Amit X; Lelgemann, Monika; Büehler, Diedrich; Schünemann, Holger J

    2017-12-01

    In this first of a series of five articles, we provide an overview of how and why healthcare-related tests and diagnostic strategies are currently applied. We also describe how our findings can be integrated with existing frameworks for making decisions that guide the use of healthcare-related tests and diagnostic strategies. We searched MEDLINE, references of identified articles, chapters in relevant textbooks, and identified articles citing classic literature on this topic. We provide updated frameworks for the potential roles and applications of tests with suggested definitions and practical examples. We also discuss study designs that are commonly used to assess tests' performance and the effects of tests on people's health. These designs include diagnostic randomized controlled trials and retrospective validation. We describe the utility of these and other currently suggested designs, which questions they can answer and which ones they cannot. In addition, we summarize the challenges unique to decision-making resulting from the use of tests. This overview highlights current challenges in the application of tests in decision-making in healthcare, provides clarifications, and informs the proposed solutions. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Methodological challenges in carbohydrate analyses

    Directory of Open Access Journals (Sweden)

    Mary Beth Hall

    2007-07-01

    Full Text Available Carbohydrates can provide up to 80% of the dry matter in animal diets, yet their specific evaluation for research and diet formulation is only now becoming a focus in the animal sciences. Partitioning of dietary carbohydrates for nutritional purposes should reflect differences in digestion and fermentation characteristics and effects on animal performance. Key challenges to designating nutritionally important carbohydrate fractions include classifying the carbohydrates in terms of nutritional characteristics, and selecting analytical methods that describe the desired fraction. The relative lack of information on digestion characteristics of various carbohydrates and their interactions with other fractions in diets means that fractions will not soon be perfectly established. Developing a system of carbohydrate analysis that could be used across animal species could enhance the utility of analyses and amount of data we can obtain on dietary effects of carbohydrates. Based on quantities present in diets and apparent effects on animal performance, some nutritionally important classes of carbohydrates that may be valuable to measure include sugars, starch, fructans, insoluble fiber, and soluble fiber. Essential to selection of methods for these fractions is agreement on precisely what carbohydrates should be included in each. Each of these fractions has analyses that could potentially be used to measure them, but most of the available methods have weaknesses that must be evaluated to see if they are fatal and the assay is unusable, or if the assay still may be made workable. Factors we must consider as we seek to analyze carbohydrates to describe diets: Does the assay accurately measure the desired fraction? Is the assay for research, regulatory, or field use (affects considerations of acceptable costs and throughput? What are acceptable accuracy and variability of measures? Is the assay robust (enhances accuracy of values? For some carbohydrates, we

  5. Relative Hazard Calculation Methodology

    International Nuclear Information System (INIS)

    DL Strenge; MK White; RD Stenner; WB Andrews

    1999-01-01

    The methodology presented in this document was developed to provide a means of calculating the RH ratios to use in developing useful graphic illustrations. The RH equation, as presented in this methodology, is primarily a collection of key factors relevant to understanding the hazards and risks associated with projected risk management activities. The RH equation has the potential for much broader application than generating risk profiles. For example, it can be used to compare one risk management activity with another, instead of just comparing it to a fixed baseline as was done for the risk profiles. If the appropriate source term data are available, it could be used in its non-ratio form to estimate absolute values of the associated hazards. These estimated values of hazard could then be examined to help understand which risk management activities are addressing the higher hazard conditions at a site. Graphics could be generated from these absolute hazard values to compare high-hazard conditions. If the RH equation is used in this manner, care must be taken to specifically define and qualify the estimated absolute hazard values (e.g., identify which factors were considered and which ones tended to drive the hazard estimation)

  6. Decision making about healthcare-related tests and diagnostic test strategies. Paper 2: a review of methodological and practical challenges

    NARCIS (Netherlands)

    Mustafa, Reem A.; Wiercioch, Wojtek; Cheung, Adrienne; Prediger, Barbara; Brozek, Jan; Bossuyt, Patrick; Garg, Amit X.; Lelgemann, Monika; Büehler, Diedrich; Schünemann, Holger J.

    2017-01-01

    Objectives: In this first of a series of five articles, we provide an overview of how and why healthcare-related tests and diagnostic strategies are currently applied. We also describe how our findings can be integrated with existing frameworks for making decisions that guide the use of

  7. App Studies : Platform Rules and Methodological Challenges

    NARCIS (Netherlands)

    Gerlitz, C.; Helmond, A.; van der Vlist, F.; Weltevrede, E.; De Groote, S.; Majmundar, P.

    2016-01-01

    The panel engages with conceptual and methodological challenges within a specific area of ‘internet rules’, namely the space of mobile apps. Whereas the web was set out to function as a ‘generative’ and open technology facilitating the production of unanticipated services and applications, the

  8. Challenges and Opportunities for Harmonizing Research Methodology

    DEFF Research Database (Denmark)

    van Hees, V. T.; Thaler-Kall, K.; Wolf, K. H.

    2016-01-01

    Objectives: Raw accelerometry is increasingly being used in physical activity research, but diversity in sensor design, attachment and signal processing challenges the comparability of research results. Therefore, efforts are needed to harmonize the methodology. In this article we reflect on how...... increased methodological harmonization may be achieved. Methods: The authors of this work convened for a two-day workshop (March 2014) themed on methodological harmonization of raw accelerometry. The discussions at the workshop were used as a basis for this review. Results: Key stakeholders were identified...... as manufacturers, method developers, method users (application), publishers, and funders. To facilitate methodological harmonization in raw accelerometry the following action points were proposed: i) Manufacturers are encouraged to provide a detailed specification of their sensors, ii) Each fundamental step...

  9. Methodological challenges in retailer buying behaviour research

    DEFF Research Database (Denmark)

    Hansen, Tommy Holm; Skytte, Hans

    This paper presents a review of studies on retailer buying behaviour with focus on the methodological issues. It is argued that the researcher of retailer buying behaviour is faced with particular challenges regarding the sample frame, defining th of analysis, potentially small populations and low...... response rates, buying centres and product specific behaviour. At the end, the authors propose a descriptive research design that will try to take account of the mentioned issues....

  10. Qualitative interviewing: methodological challenges in Arab settings.

    Science.gov (United States)

    Hawamdeh, Sana; Raigangar, Veena

    2014-01-01

    To explore some of the main methodological challenges faced by interviewers in Arab settings, particularly during interviews with psychiatric nurses. Interviews are a tool used commonly in qualitative research. However, the cultural norms and practices of interviewees must be considered to ensure that an appropriate interviewing style is used, a good interviewee-interviewer relationship formed and consent for participation obtained sensitively. A study to explore the nature of psychiatric nurses' practices that used unstructured interviews. This is a methodology paper that discusses a personal experience of addressing many challenges that are specific to qualitative interviewing in Arab settings, supported by literature on the topic. Suggestions for improving the interview process to make it more culturally sensitive are provided and recommendations for future research are made. Openness, flexibility and a reflexive approach by the researcher can help manage challenges in Arab settings. Researchers should allow themselves to understand the cultural elements of a population to adapt interviewing methods with the aim of generating high quality qualitative research.

  11. Assessing species saturation: conceptual and methodological challenges.

    Science.gov (United States)

    Olivares, Ingrid; Karger, Dirk N; Kessler, Michael

    2018-05-07

    Is there a maximum number of species that can coexist? Intuitively, we assume an upper limit to the number of species in a given assemblage, or that a lineage can produce, but defining and testing this limit has proven problematic. Herein, we first outline seven general challenges of studies on species saturation, most of which are independent of the actual method used to assess saturation. Among these are the challenge of defining saturation conceptually and operationally, the importance of setting an appropriate referential system, and the need to discriminate among patterns, processes and mechanisms. Second, we list and discuss the methodological approaches that have been used to study species saturation. These approaches vary in time and spatial scales, and in the variables and assumptions needed to assess saturation. We argue that assessing species saturation is possible, but that many studies conducted to date have conceptual and methodological flaws that prevent us from currently attaining a good idea of the occurrence of species saturation. © 2018 Cambridge Philosophical Society.

  12. Methodological Challenges of Research in Nudging

    NARCIS (Netherlands)

    Kleef, van E.; Trijp, van J.C.M.

    2018-01-01

    Complex societal issues, related to health and sustainability, provide major challenges to scientists, business managers, and policy makers alike. Despite their diversity, these issues have in common that effective solutions to public health (e.g., reducing prevalence of overweight and obesity) and

  13. Family Photography and Persecuted Communities: Methodological Challenges.

    Science.gov (United States)

    McAllister, Kirsten Emiko

    2018-05-01

    This paper examines methodological challenges involved in conducting research on family photographs from persecuted communities, using Japanese Canadian photos as a case study. Approaching family photography as a social practice that instills dominant familial ideologies, the paper examines their "performative scripts" that arrange family members according to normative identities and roles. The paper argues that researchers are not immune to scripts that shape how and what we have been socialized to see (and not see) in family photos. The paper thus presents techniques to distance oneself from these performative scripts and one's involvement in their social and emotional dynamics. Once able to disentangle oneself from the genre's normative practices, the paper argues it is necessary to situate the photos in their social and political context of persecution and survival. Given the insular, inward looking character of family photographs, the paper concludes by calling for intersectional analyses, reflecting on how one might bring one's own family photos into engagement with the photos of Indigenous families and turns to those of the Skwxwú7mesh (Squamish) Nation. © 2018 Canadian Sociological Association/La Société canadienne de sociologie.

  14. Challenges in dental statistics: survey methodology topics

    OpenAIRE

    Pizzo, Giuseppe; Milani, Silvano; Spada, Elena; Ottolenghi, Livia

    2013-01-01

    This paper gathers some contributions concerning survey methodology in dental research, as discussed during the first Workshop of the SISMEC STATDENT working group on statistical methods and applications in dentistry, held in Ancona on the 28th September 2011.The first contribution deals with the European Global Oral Health Indicators Development (EGOHID) Project which proposed a comprehensive and standardized system of epidemiological tools (questionnaires and clinical forms) for national da...

  15. Sex Work Research: Methodological and Ethical Challenges

    Science.gov (United States)

    Shaver, Frances M.

    2005-01-01

    The challenges involved in the design of ethical, nonexploitative research projects with sex workers or any other marginalized population are significant. First, the size and boundaries of the population are unknown, making it extremely difficult to get a representative sample. Second, because membership in hidden populations often involves…

  16. Vulnerable participants in health research: methodological and ethical challenges

    DEFF Research Database (Denmark)

    Nordentoft, Helle Merete; Kappel, Nanna

    2011-01-01

    , leaving both professionals and researchers in ethical and moral dilemmas. In this article, we specifically focus on the methodological challenges of obtaining informed consent from drug users and terminally ill cancer patients in our PhD research. The question is how to illuminate the needs and problems......Ethical guidelines for conducting research are embedded in the Helsinki Declaration of 1964. We contend that these abstract and intentionally universal guidelines need to be appropriated for social and healthcare research, in which purpose and methods often deviate from medical research....... The guidelines appear to be instrumental and over-simplistic representations of the often ‘messy’ realities surrounding the research process that is often guided by relational and local negotiations of ethical solutions. Vulnerable participants, for instance, challenge both professional and research ethics...

  17. Challenges in dental statistics: survey methodology topics

    Directory of Open Access Journals (Sweden)

    Giuseppe Pizzo

    2013-12-01

    Full Text Available This paper gathers some contributions concerning survey methodology in dental research, as discussed during the first Workshop of the SISMEC STATDENT working group on statistical methods and applications in dentistry, held in Ancona on the 28th September 2011.The first contribution deals with the European Global Oral Health Indicators Development (EGOHID Project which proposed a comprehensive and standardized system of epidemiological tools (questionnaires and clinical forms for national data collection on oral health in Europe. The second contribution regards the design and conduct of trials to evaluate the clinical efficacy and safety of toothbrushes and mouthrinses. Finally, a flexible and effective tool used to trace dental age reference charts tailored to Italian children is presented.

  18. Challenging Scandinavian employment relations

    DEFF Research Database (Denmark)

    Ibsen, Christian Lyhne; Larsen, Trine Pernille; Madsen, Jørgen Steen

    2011-01-01

    and employment relations in the Danish, Norwegian and Swedish public sector. In this paper, we argue that although differences exist across the Scandinavian countries, it is evident that they have managed to adopt and implement NPM-inspired reforms without dismantling their universal welfare services and strong......Building on the convergence/divergence approach, this paper examines whether recent new public management (NPM) inspired reforms entailing inter alia cutbacks in the public sector, marketisation and management by performance measures have had significant implications for service provision...... traditions of collective bargaining in the public sector. However, this restructuring is taking its toll on the work environment....

  19. International Relations Research Methodology: Realism

    Directory of Open Access Journals (Sweden)

    Andrey Vladimirovich Shabaga

    2015-12-01

    Full Text Available The article examines the origins and conceptual analysis capabilities of international relations in the framework of a realistic paradigm. We research political conditions and preconditions of the creation of realism’s theory and axiological features of realism’s practice in international relations. We also analyze the basic concepts and schools of realism: Realpolitik, political realism, neorealism, neoclassical realism. It is shown that based on the balance of power in the Realpolitik Prussian and Austrian cases, this understanding of politics within the systematics of the XIX century; the adaptation of the bourgeois liberal and national ideas to the foreign-policy specifics Germany middle of the XIX century. It is shown that political realism is targeting an international actor on the desire to subjugate the greatest possible political space. In the case of political weakness (absolute or relative political realism indicates a way of adapting to circumstances in order to achieve the most desirable of the possible. The article discusses the concept A. Rochau, H. Morgenthau, H. Kissinger, K. Waltz, showing differences and instrumentality realistic theories and concludes that the main provisions of the concept as a whole.

  20. Two Methodological Challenges for Teacher-Researchers: Reflexivity and Trustworthiness

    Science.gov (United States)

    Xerri, Daniel

    2018-01-01

    Teacher research is lauded as a beneficial enterprise both for practitioners and for learners. However, teachers are sometimes accused of not possessing the necessary knowledge and skills to conduct research effectively. This article focuses on the need for teacher-researchers to find means of addressing the methodological challenges of engaging…

  1. Biomimetics as a design methodology – possibilities and challenges

    DEFF Research Database (Denmark)

    Lenau, Torben Anker

    2009-01-01

    Biomimetics – or bionik as it is called in parts of Europe – offer a number of promising opportunities and challenges for the designer. The paper investigates how biomimetics as a design methodology is used in engineering design by looking at examples of biological searches and highlight...

  2. Challenges and Prospects of Methodological Anarchism for Science ...

    African Journals Online (AJOL)

    This paper examjnes Feyerabend's idea of Methodological Anarchism. Specifically, it looks at its challenges and prospects for the growth of science and epistemology in Africa. Feyerabend's point is that people develop best in pluralistic societies; that contain many ideas, traditions and forms of life. It is argued that ...

  3. Economic evaluation in stratified medicine: methodological issues and challenges

    Directory of Open Access Journals (Sweden)

    Hans-Joerg eFugel

    2016-05-01

    Full Text Available Background: Stratified Medicine (SM is becoming a practical reality with the targeting of medicines by using a biomarker or genetic-based diagnostic to identify the eligible patient sub-population. Like any healthcare intervention, SM interventions have costs and consequences that must be considered by reimbursement authorities with limited resources. Methodological standards and guidelines exist for economic evaluations in clinical pharmacology and are an important component for health technology assessments (HTAs in many countries. However, these guidelines have initially been developed for traditional pharmaceuticals and not for complex interventions with multiple components. This raises the issue as to whether these guidelines are adequate to SM interventions or whether new specific guidance and methodology is needed to avoid inconsistencies and contradictory findings when assessing economic value in SM.Objective: This article describes specific methodological challenges when conducting health economic (HE evaluations for SM interventions and outlines potential modifications necessary to existing evaluation guidelines /principles that would promote consistent economic evaluations for SM.Results/Conclusions: Specific methodological aspects for SM comprise considerations on the choice of comparator, measuring effectiveness and outcomes, appropriate modelling structure and the scope of sensitivity analyses. Although current HE methodology can be applied for SM, greater complexity requires further methodology development and modifications in the guidelines.

  4. ASSESSMENT OF QUALITY OF LIFE: PRESENT AND FUTURE METHODOLOGICAL CHALLENGES

    Directory of Open Access Journals (Sweden)

    Isabel Benítez

    2016-01-01

    Full Text Available The growing importance of quality of life in diverse domains, such as health, school performance and social participation, has led to the development of new conceptualisations and assessments of the construct. This diversity of perspectives brings about many benefits, but it also creates an obstacle for the formulation of a single unifying definition of the construct and, therefore, an agreed instrument or assessment framework. The aim of this study is to discuss the current methodological challenges in the measurement of quality of life. Firstly, we provide a brief description of the construct as defined in various areas, then we examine the new methodological developments and different applications. We also present an overview of the different possibilities for future developments in defining and measuring quality of life in national and international studies.

  5. Challenge of superfund community relations

    International Nuclear Information System (INIS)

    Goldman, N.J.

    1991-01-01

    Conducting a community relations effort in a community which is home to a Superfund site is a formidable challenge. Any education press, however appropriate, quickly falls victim to doubt, mistrust of fears of the very public intended to be served by the effort. While each site is uniquely different, the issues raised by affected communities in one part of the country are strikingly similar to those raised in other parts. Those most involved must join those most affected in seeking meaningful solutions and in building the trust that is so vital in moving forward with Superfund

  6. Contemporary challenges for intrafamilial relations

    Directory of Open Access Journals (Sweden)

    M. GOTEA

    2016-11-01

    Full Text Available Nowadays we live in a time of rapid changes, from a social, industrial and technological standpoint. Profound mutations in family institution can be observed, regarding the family structure, lifestyle and the cycle of family life. Today’s tendencies reflect a clear distinction between marriage and the activity of raising children, as we can notice the increased number of marriages without children or the number of single-parent families. That is why, the present paper focus on these two types of intrafamily relationships: couple’s relationship and parent-child relation, pointing out some changes and challenges of contemporary period.

  7. Methodologies for nuclear material accounting and control: challenges and expectations

    International Nuclear Information System (INIS)

    Ramakumar, K.L.

    2007-01-01

    Nuclear Material Accounting and Control (NUMAC) represents one of the most important and indispensable responsibilities of any nuclear installation. The emphasis is to ensure that the nuclear material being handled in the nuclear installation is properly accounted for with the expected accuracy and confidence levels. A number of analytical methods based on both destructive and non-destructive assay techniques are available at the disposal of the nuclear analytical scientists for this purpose and they have been enumerated extensively in literature. Instead of recounting the analytical methodologies available, an attempt has been made in this paper to highlight some of the challenges. (author)

  8. Methodological challenges in qualitative content analysis: A discussion paper.

    Science.gov (United States)

    Graneheim, Ulla H; Lindgren, Britt-Marie; Lundman, Berit

    2017-09-01

    This discussion paper is aimed to map content analysis in the qualitative paradigm and explore common methodological challenges. We discuss phenomenological descriptions of manifest content and hermeneutical interpretations of latent content. We demonstrate inductive, deductive, and abductive approaches to qualitative content analysis, and elaborate on the level of abstraction and degree of interpretation used in constructing categories, descriptive themes, and themes of meaning. With increased abstraction and interpretation comes an increased challenge to demonstrate the credibility and authenticity of the analysis. A key issue is to show the logic in how categories and themes are abstracted, interpreted, and connected to the aim and to each other. Qualitative content analysis is an autonomous method and can be used at varying levels of abstraction and interpretation. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Sulfonylurea herbicides – methodological challenges in setting aquatic limit values

    DEFF Research Database (Denmark)

    Rosenkrantz, Rikke Tjørnhøj; Baun, Anders; Kusk, Kresten Ole

    according to the EU Water Framework Directive, the resulting Water Quality Standards (WQSs) are below the analytical quantification limit, making it difficult to verify compliance with the limit values. However, several methodological concerns may be raised in relation to the very low effect concentrations...... and rimsulfuron. The following parameters were varied during testing: pH, exposure duration, temperature and light/dark cycle. Preliminary results show that a decrease in pH causes an increase in toxicity for all compounds. Exposure to a high concentration for 24 hours caused a reduction in growth rate, from...... for setting limit values for SUs or if more detailed information should be gained by taking methodological considerations into account....

  10. Relative Hazard and Risk Measure Calculation Methodology Rev 1

    International Nuclear Information System (INIS)

    Stenner, Robert D.; White, Michael K.; Strenge, Dennis L.; Aaberg, Rosanne L.; Andrews, William B.

    2000-01-01

    Documentation of the methodology used to calculate relative hazard and risk measure results for the DOE complex wide risk profiles. This methodology is used on major site risk profiles. In February 1997, the Center for Risk Excellence (CRE) was created and charged as a technical, field-based partner to the Office of Science and Risk Policy (EM-52). One of the initial charges to the CRE is to assist the sites in the development of ''site risk profiles.'' These profiles are to be relatively short summaries (periodically updated) that present a broad perspective on the major risk related challenges that face the respective site. The risk profiles are intended to serve as a high-level communication tool for interested internal and external parties to enhance the understanding of these risk-related challenges. The risk profiles for each site have been designed to qualitatively present the following information: (1) a brief overview of the site, (2) a brief discussion on the historical mission of the site, (3) a quote from the site manager indicating the site's commitment to risk management, (4) a listing of the site's top risk-related challenges, (5) a brief discussion and detailed table presenting the site's current risk picture, (6) a brief discussion and detailed table presenting the site's future risk reduction picture, and (7) graphic illustrations of the projected management of the relative hazards at the site. The graphic illustrations were included to provide the reader of the risk profiles with a high-level mental picture to associate with all the qualitative information presented in the risk profile. Inclusion of these graphic illustrations presented the CRE with the challenge of how to fold this high-level qualitative risk information into a system to produce a numeric result that would depict the relative change in hazard, associated with each major risk management action, so it could be presented graphically. This report presents the methodology developed

  11. The challenges facing ethnographic design research: A proposed methodological solution

    DEFF Research Database (Denmark)

    Cash, Philip; Hicks, Ben; Culley, Steve

    2009-01-01

    Central to improving and maintaining high levels of performance in emerging ethnographic design research is a fundamental requirement to address some of the problems associated with the subject. In particular seven core issues are identified and include the complexity of test development......, variability of methods, resource intensiveness, subjectivity, comparability, common metrics and industrial acceptance. To address these problems this paper describes a structured methodological approach in which three main areas are proposed, the modularisation of the research process, the standardisation...... of the dataset and the stratification of the research context. The paper then examines the fundamental requirements of this scheme and how these relate to a Design Observatory approach. Following this, the proposed solution is related back to the initial problem set and potential issues are discussed. Finally...

  12. Caffeine and cognitive performance: persistent methodological challenges in caffeine research.

    Science.gov (United States)

    James, Jack E

    2014-09-01

    Human cognitive performance is widely perceived to be enhanced by caffeine at usual dietary doses. However, the evidence for and against this belief continues to be vigorously contested. Controversy has centred on caffeine withdrawal and withdrawal reversal as potential sources of experimental confounding. In response, some researchers have enlisted "caffeine-naïve" experimental participants (persons alleged to consume little or no caffeine) assuming that they are not subject to withdrawal. This mini-review examines relevant research to illustrate general methodological challenges that have been the cause of enduring confusion in caffeine research. At issue are the processes of caffeine withdrawal and withdrawal reversal, the definition of caffeine-naïve, the population representativeness of participants deemed to be caffeine-naïve, and confounding due to caffeine tolerance. Attention to these processes is necessary if premature conclusions are to be avoided, and if caffeine's complex effects and the mechanisms responsible for those effects are to be illuminated. Strategies are described for future caffeine research aimed at minimising confounding from withdrawal and withdrawal reversal. Copyright © 2014 Elsevier Inc. All rights reserved.

  13. Clinical Studies of Biofield Therapies: Summary, Methodological Challenges, and Recommendations

    Science.gov (United States)

    Hammerschlag, Richard; Mills, Paul; Cohen, Lorenzo; Krieger, Richard; Vieten, Cassandra; Lutgendorf, Susan

    2015-01-01

    Biofield therapies are noninvasive therapies in which the practitioner explicitly works with a client's biofield (interacting fields of energy and information that surround living systems) to stimulate healing responses in patients. While the practice of biofield therapies has existed in Eastern and Western cultures for thousands of years, empirical research on the effectiveness of biofield therapies is still relatively nascent. In this article, we provide a summary of the state of the evidence for biofield therapies for a number of different clinical conditions. We note specific methodological issues for research in biofield therapies that need to be addressed (including practitioner-based, outcomes-based, and research design considerations), as well as provide a list of suggested next steps for biofield researchers to consider. PMID:26665043

  14. The Challenges of Participant Photography: A Critical Reflection on Methodology and Ethics in Two Cultural Contexts.

    Science.gov (United States)

    Murray, Linda; Nash, Meredith

    2017-05-01

    Photovoice and photo-elicitation are two common methods of participant photography used in health research. Although participatory photography has many benefits, this critical reflection provides fellow researchers with insights into the methodological and ethical challenges faced when using such methods. In this article, we critically reflect on two studies that used participatory photography in different cultural contexts. The first study used photo-elicitation to investigate mothers' experiences of infant settling in central Vietnam. The second study used photovoice to explore pregnant embodiment in Australia. Following a discussion of the literature and a detailed overview of the two studies, we examine the methodological challenges in using participant photography before, during and after each study. This is followed by a discussion of ethical concerns that arose in relation to the burden of participation, confidentiality, consent, and the photographing of families and children. To conclude, we highlight implications for using participatory photography in other settings.

  15. Challenges in implementing a Planetary Boundaries based Life-Cycle Impact Assessment methodology

    DEFF Research Database (Denmark)

    Ryberg, Morten; Owsianiak, Mikolaj; Richardson, Katherine

    2016-01-01

    of resolving the challenges and developing such methodology is discussed. The challenges are related to technical issues, i.e., modelling and including the Earth System processes and their control variables as impact categories in Life-Cycle Impact Assessment and to theoretical considerations with respect...... to the interpretation and use of Life-Cycle Assessment results in accordance with the Planetary Boundary framework. The identified challenges require additional research before a Planetary Boundaries based Life-Cycle Impact Assessment method can be developed. Research on modelling the impacts on Earth System processes......Impacts on the environment from human activities are now threatening to exceed thresholds for central Earth System processes, potentially moving the Earth System out of the Holocene state. To avoid such consequences, the concept of Planetary Boundaries was defined in 2009, and updated in 2015...

  16. Methodological challenges when doing research that includes ethnic minorities

    DEFF Research Database (Denmark)

    Morville, Anne-Le; Erlandsson, Lena-Karin

    2016-01-01

    minorities are included. Method: A thorough literature search yielded 21 articles obtained from the scientific databases PubMed, Cinahl, Web of Science and PsychInfo. Analysis followed Arksey and O’Malley’s framework for scoping reviews, applying content analysis. Results: The results showed methodological...

  17. Relative Hazard and Risk Measure Calculation Methodology

    International Nuclear Information System (INIS)

    Stenner, Robert D.; Strenge, Dennis L.; Elder, Matthew S.; Andrews, William B.; Walton, Terry L.

    2003-01-01

    The RHRM equations, as represented in methodology and code presented in this report, are primarily a collection of key factors normally used in risk assessment that are relevant to understanding the hazards and risks associated with projected mitigation, cleanup, and risk management activities. The RHRM code has broad application potential. For example, it can be used to compare one mitigation, cleanup, or risk management activity with another, instead of just comparing it to just the fixed baseline. If the appropriate source term data are available, it can be used in its non-ratio form to estimate absolute values of the associated controlling hazards and risks. These estimated values of controlling hazards and risks can then be examined to help understand which mitigation, cleanup, or risk management activities are addressing the higher hazard conditions and risk reduction potential at a site. Graphics can be generated from these absolute controlling hazard and risk values to graphically compare these high hazard and risk reduction potential conditions. If the RHRM code is used in this manner, care must be taken to specifically define and qualify (e.g., identify which factors were considered and which ones tended to drive the hazard and risk estimates) the resultant absolute controlling hazard and risk values

  18. Health effects of ambient air pollution – recent research development and contemporary methodological challenges

    Directory of Open Access Journals (Sweden)

    Ren Cizao

    2008-11-01

    Full Text Available Abstract Exposure to high levels of air pollution can cause a variety of adverse health outcomes. Air quality in developed countries has been generally improved over the last three decades. However, many recent epidemiological studies have consistently shown positive associations between low-level exposure to air pollution and health outcomes. Thus, adverse health effects of air pollution, even at relatively low levels, remain a public concern. This paper aims to provide an overview of recent research development and contemporary methodological challenges in this field and to identify future research directions for air pollution epidemiological studies.

  19. Local and regional low carbon scenarios methodology, challenges and opportunities

    International Nuclear Information System (INIS)

    2010-01-01

    In its first part, this report discusses the emergence of local climate and energy policy in Europe, the implementation of nationally imposed but regionally anchored energy scenarios (i.e. in France, the Climate Air Energy Regional Schemes or SRCAE). Then it addresses the methodological and political aspects of local and regional low emission scenarios: methodologies and typologies of energy scenarios, ways to define an appropriate emission reduction and energy consumption objective, ways to deal with emission or carbon gaps, ways to make local emission inventories, ways to gather local data, ways to deal with special emission sources, ways to assess and develop local energy efficiency and renewable energy potentials, ways to take energy sufficiency into account, and the evolution from energy autonomy to 100% renewable energy territories. The last part addresses the issues of stake holder and citizen participation in the definition of long term strategies

  20. The Societal Nature of Subjectivity: An Interdisciplinary Methodological Challenge

    Directory of Open Access Journals (Sweden)

    Henning Salling Olesen

    2012-09-01

    Full Text Available The thematic issue presents a psycho-societal approach to qualitative empirical research in several areas of everyday social life. It is an approach which integrates a theory of subjectivity and an interpretation methodology which integrates hermeneutic experiences from text analysis and psychoanalysis. Its particular focus is on subjectivity—as an aspect of the research object and as an aspect of the research process. By the term "approach" is indicated the intrinsic connection between the theorizing of an empirical object and the reflection of the research process and the epistemic subject. In terms of methodology it revives the themes originally launched in FQS exactly ten years ago: "Subjectivity and Reflectivity in Qualitative Research" (BREUER, MRUCK & ROTH, 2002; MRUCK & BREUER, 2003. This editorial introduction presents the intellectual background of the psycho-societal methodology, reflects on its relevance and critical perspectives in a contemporary landscape of social science, and comments the way in which an international and interdisciplinary research group has developed this approach to profane empirical research. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs120345

  1. The origin of life and its methodological challenge.

    Science.gov (United States)

    Wächtershäuser, G

    1997-08-21

    The problem of the origin of life is discussed from a methodological point of view as an encounter between the teleological thinking of the historian and the mechanistic thinking of the chemist; and as the Kantian task of replacing teleology by mechanism. It is shown how the Popperian situational logic of historic understanding and the Popperian principle of explanatory power of scientific theories, when jointly applied to biochemistry, lead to a methodology of biochemical retrodiction, whereby common precursor functions are constructed for disparate successor functions. This methodology is exemplified by central tenets of the theory of the chemo-autotrophic origin of life: the proposal of a surface metabolism with a two-dimensional order; the basic polarity of life with negatively charged constituents on positively charged mineral surfaces; the surface-metabolic origin of phosphorylated sugar metabolism and nucleic acids; the origin of membrane lipids and of chemi-osmosis on pyrite surfaces; and the principles of the origin of the genetic machinery. The theory presents the early evolution of life as a process that begins with chemical necessity and winds up in genetic chance.

  2. Methodological challenges involved in compiling the Nahua pharmacopeia.

    Science.gov (United States)

    De Vos, Paula

    2017-06-01

    Recent work in the history of science has questioned the Eurocentric nature of the field and sought to include a more global approach that would serve to displace center-periphery models in favor of approaches that take seriously local knowledge production. Historians of Iberian colonial science have taken up this approach, which involves reliance on indigenous knowledge traditions of the Americas. These traditions present a number of challenges to modern researchers, including availability and reliability of source material, issues of translation and identification, and lack of systematization. This essay explores the challenges that emerged in the author's attempt to compile a pre-contact Nahua pharmacopeia, the reasons for these challenges, and the ways they may - or may not - be overcome.

  3. Risk assessment of cryogenic installations – implementation, applicability of methodologies and challenges at CERN

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    For the safe design of a cryogenic installation, it is essential to carry out a comprehensive hazard identification and risk estimate in order to put in place the necessary control measures for an adequate risk mitigation. According to CERN Safety Rules, it is mandatory that the organic unit owning a cryogenic facility conducts and documents a risk assessment. This requirement is also given by the European Directive 2014/68/EU to manufacturers of pressure equipment. During the talk, some of the challenges CERN faces in the development of risk assessments across the broad array of activities involving cryogenic equipment in the organization will be discussed. Challenges such as the choice of the best-suited risk assessment methodology based on the features and complexity of the installation/activities, the efforts to develop tools to facilitate hazard identification, risk analysis and definition of related measures to protect the health and safety of workers, such as streamlined guidelines, forms and check...

  4. Introduction to Visual Communication in the Age of Social Media: Conceptual, Theoretical and Methodological Challenges

    Directory of Open Access Journals (Sweden)

    Uta Russmann

    2017-12-01

    Full Text Available This thematic issue of Media and Communication focuses attention on the shift towards visual images on social media as well as the transformation of visual communication which has occurred within the online ecology of social media platforms. The sharing of images is becoming an integral part of the social media experience today, and given that social media platforms are the prime locus for sociability—at least among young people in the West—this shift towards visuals arguably transforms how we relate to each other and the world around us, as well as how we perceive and construct our sense of self. For researchers, this raises conceptual, theoretical and methodological challenges. This thematic issue presents six articles as well as a book review on visual communication in social media focusing on developing a conceptual apparatus and precise definitions of objects and practices of study as well as contributions that address and discuss the methodological challenges as well as their potential solutions. The idea was to synergize research from a wide variety of communication-related disciplines on this rather new topic.

  5. The appropriation of new media and the interrelation with social change in Uasin Gishu, Kenya - methodological and epistemological challenges

    DEFF Research Database (Denmark)

    Gustafsson, Jessica; Nielsen, Poul Erik

    The aim of this paper is to theoretically and empirically discuss methodological challenges related to studying the interrelations between the appropriations of new media and socio-cultural changes in the Global South. Empirically the paper takes its point of departure in three sub-projects within...

  6. Video ethnography during and after caesarean sections: methodological challenges.

    Science.gov (United States)

    Stevens, Jeni; Schmied, Virginia; Burns, Elaine; Dahlen, Hannah G

    2017-07-01

    To describe the challenges of, and steps taken to successfully collect video ethnographic data during and after caesarean sections. Video ethnographic research uses real-time video footage to study a cultural group or phenomenon in the natural environment. It allows researchers to discover previously undocumented practices, which in-turn provides insight into strengths and weaknesses in practice. This knowledge can be used to translate evidence-based interventions into practice. Video ethnographic design. A video ethnographic approach was used to observe the contact between mothers and babies immediately after elective caesarean sections in a tertiary hospital in Sydney, Australia. Women, their support people and staff participated in the study. Data were collected via video footage and field notes in the operating theatre, recovery and the postnatal ward. Challenges faced whilst conducting video ethnographic research included attaining ethics approval, recruiting vast numbers of staff members and 'vulnerable' pregnant women, and endeavouring to be a 'fly on the wall' and a 'complete observer'. There were disadvantages being an 'insider' whilst conducting the research because occasionally staff members requested help with clinical tasks whilst collecting data; however, it was an advantage as it enabled ease of access to the environment and staff members that were to be recruited. Despite the challenges, video ethnographic research enabled the provision of unique data that could not be attained by any other means. Video ethnographic data are beneficial as it provides exceptionally rich data for in-depth analysis of interactions between the environment, equipment and people in the hospital environment. The analysis of this type of data can then be used to inform improvements for future care. © 2016 John Wiley & Sons Ltd.

  7. Organizational ethnography and methodological angst: Myths and challenges in the field

    NARCIS (Netherlands)

    Yanow, D.

    2009-01-01

    Purpose – The purpose of this paper is to assess the myths and challenges in the field of organizational ethnography and methodological angst. Design/methodology/approach – This paper is initially written as an invited keynote address for the 3rd Annual Joint Symposium on “Current Developments in

  8. Conducting Research with LGB People of Color: Methodological Challenges and Strategies

    Science.gov (United States)

    DeBlaere, Cirleen; Brewster, Melanie E.; Sarkees, Anthony; Moradi, Bonnie

    2010-01-01

    Methodological barriers have been highlighted as a primary reason for the limited research with lesbian, gay, and bisexual (LGB) people of color. Thus, strategies for anticipating and addressing potential methodological barriers are needed. To address this need, this article discusses potential challenges associated with conducting research with…

  9. Learning challenges and sustainable development: A methodological perspective.

    Science.gov (United States)

    Seppänen, Laura

    2017-01-01

    Sustainable development requires learning, but the contents of learning are often complex and ambiguous. This requires new integrated approaches from research. It is argued that investigation of people's learning challenges in every-day work is beneficial for research on sustainable development. The aim of the paper is to describe a research method for examining learning challenges in promoting sustainable development. This method is illustrated with a case example from organic vegetable farming in Finland. The method, based on Activity Theory, combines historical analysis with qualitative analysis of need expressions in discourse data. The method linking local and subjective need expressions with general historical analysis is a promising way to overcome the gap between the individual and society, so much needed in research for sustainable development. Dialectically informed historical frameworks have practical value as tools in collaborative negotiations and participatory designs for sustainable development. The simultaneous use of systemic and subjective perspectives allows researchers to manage the complexity of practical work activities and to avoid too simplistic presumptions about sustainable development.

  10. Socioeconomic value of orthopedic devices: evidence and methodological challenges

    Directory of Open Access Journals (Sweden)

    Sorenson C

    2012-10-01

    Full Text Available Corinna Sorenson,1,2 Michael Drummond2,31LSE Health, London School of Economics, London, UK; 2European Health Technology Institute for Socioeconomic Research, Brussels, Belgium; 3Centre for Health Economics, University of York, York, UKAbstract: With continued technological advances in orthopedic devices and increasingly limited health care resources, greater attention will be placed on substantiating the socioeconomic value of these devices. Therefore, this study focused on a systematic review of available economic evaluations of selected orthopedic devices (n = 33 studies to assess their impact on different clinical and economic outcomes. The existing evidence suggests that they have important benefits to patients, including reduced risk of fractures, increased mobility and functioning, and enhanced quality of life, and do so cost effectively or with cost savings. However, we have identified several methodological obstacles to sufficient ascertainment of value, such as a lack of robust information on health economic outcomes and long-term evidence. We also identify areas where additional research is needed to assess more fully the value of orthopedic devices.Keywords: medical devices, orthopedics, health economic evaluation

  11. Temperature biofeedback and sleep: limited findings and methodological challenges

    Directory of Open Access Journals (Sweden)

    De Koninck J

    2012-10-01

    Full Text Available Geneviève Forest,1,2 Cameron van den Heuvel,3 Kurt Lushington,4 Joseph De Koninck21Sleep Laboratory, Département de Psychoéducation et de Psychologie, Université du Québec en Outaouais, Gatineau, Québec, Canada; 2Sleep and Dreams Laboratory, School of Psychology, University of Ottawa, Ottawa, Ontario, Canada; 3Research Branch University of Adelaide, South Australia, Australia; 4School of Psychology, Social Work and Social Policy, University of South Australia, South Australia, AustraliaAbstract: Given the close link between body temperature and sleep, the perspective of manipulating core and peripheral temperature by self-regulation techniques is very appealing. We report here on a series of attempts conducted independently in two laboratories to use self-regulation (biofeedback of oral (central and hand (peripheral temperature, and measured the impact on sleep-onset latency, sleep architecture, and circadian phase. We found that hand temperature was more successful than oral temperature biofeedback. Moreover, an increase in hand temperature was associated with reduced sleep-onset latency. However, most participants found the procedure difficult to implement. The temperature response to biofeedback was reduced in the aged and weakest at the time of sleep onset, and there was not a systematic relationship between the change in temperature and change in sleep latency. Methodological limitations and individual differences may account for these results. Recommendations for future research are presented.Keywords: biofeedback, core body temperature, sleep, circadian rhythm, sleep onset

  12. Organizational Culture and Scale Development: Methodological Challenges and Future Directions

    Directory of Open Access Journals (Sweden)

    Bavik Ali

    2014-12-01

    Full Text Available Defining and measuring organizational culture (OC is of paramount importance to organizations because a strong culture could potentially increase service quality and yield sustainable competitive advantages. However, such process could be challenging to managers because the scope of OC has been defined differently across disciplines and industries, which has led to the development of various scales for measuring OC. In addition, previously developed OC scales may also not be fully applicable in the hospitality and tourism context. Therefore, by highlighting the key factors affecting the business environment and the unique characteristics of hospitality industry, this paper aims to align the scope of OC closely with the industry and to put forth the need for a new OC scale that accurately responds to the context of the hospitality industry.

  13. Socio-Hydrology: Conceptual and Methodological Challenges in the Bidirectional Coupling of Human and Water Systems

    Science.gov (United States)

    Scott, C. A.

    2014-12-01

    This presentation reviews conceptual advances in the emerging field of socio-hydrology that focuses on coupled human and water systems. An important current challenge is how to better couple the bidirectional influences between human and water systems, which lead to emergent dynamics. The interactions among (1) the structure and dynamics of systems with (2) human values and norms lead to (3) outcomes, which in turn influence subsequent interactions. Human influences on hydrological systems are relatively well understood, chiefly resulting from developments in the field of water resources. The ecosystem-service concept of cultural value has expanded understanding of decision-making beyond economic rationality criteria. Hydrological impacts on social processes are less well developed conceptually, but this is changing with growing attention to vulnerability, adaptation, and resilience, particularly in the face of climate change. Methodological limitations, especially in characterizing the range of human responses to hydrological events and drivers, still pose challenges to modeling bidirectional human-water influences. Evidence from multiple case studies, synthesized in more broadly generic syndromes, helps surmount these methodological limitations and offers the potential to improve characterization and quantification of socio-hydrological systems.

  14. Synthesis in land change science: methodological patterns, challenges, and guidelines.

    Science.gov (United States)

    Magliocca, Nicholas R; Rudel, Thomas K; Verburg, Peter H; McConnell, William J; Mertz, Ole; Gerstner, Katharina; Heinimann, Andreas; Ellis, Erle C

    Global and regional economic and environmental changes are increasingly influencing local land-use, livelihoods, and ecosystems. At the same time, cumulative local land changes are driving global and regional changes in biodiversity and the environment. To understand the causes and consequences of these changes, land change science (LCS) draws on a wide array synthetic and meta-study techniques to generate global and regional knowledge from local case studies of land change. Here, we review the characteristics and applications of synthesis methods in LCS and assess the current state of synthetic research based on a meta-analysis of synthesis studies from 1995 to 2012. Publication of synthesis research is accelerating, with a clear trend toward increasingly sophisticated and quantitative methods, including meta-analysis. Detailed trends in synthesis objectives, methods, and land change phenomena and world regions most commonly studied are presented. Significant challenges to successful synthesis research in LCS are also identified, including issues of interpretability and comparability across case-studies and the limits of and biases in the geographic coverage of case studies. Nevertheless, synthesis methods based on local case studies will remain essential for generating systematic global and regional understanding of local land change for the foreseeable future, and multiple opportunities exist to accelerate and enhance the reliability of synthetic LCS research in the future. Demand for global and regional knowledge generation will continue to grow to support adaptation and mitigation policies consistent with both the local realities and regional and global environmental and economic contexts of land change.

  15. Ethical challenges related to next of kin - nursing staffs' perspective.

    Science.gov (United States)

    Tønnessen, Siri; Solvoll, Betty-Ann; Brinchmann, Berit Støre

    2016-11-01

    Patients in clinical settings are not lonely islands; they have relatives who play a more or less active role in their lives. The purpose of this article is to elucidate the ethical challenges nursing staff encounter with patients' next of kin and to discuss how these challenges affect clinical practice. The study is based on data collected from ethical group discussions among nursing staff in a nursing home. The discussions took place in 2011 and 2012. The data were analysed and interpreted by using hermeneutic methodology. All the data have been anonymised and handled with confidentiality. Written informed consent was obtained from all participants. Ethical challenges relating to patients' next of kin were found to be an issue frequently discussed in the groups. Our findings indicate that next of kin have different characteristics, categorised as 'the professionals' and 'the shadows'. In this article, we will describe the next of kin's characteristics and the ethical challenges and practical implications that nursing staff experience in this connection. We will discuss the findings in the light of the four basic principles of medical ethics and propose interventions to help nurses manage ethical challenges related to next of kin. The study reveals the need to enhance nursing staffs' communicative and ethical skills on an individual level, but most importantly, to establish routines in clinical settings for informing and following up next of kin in a systematic and structured way. © The Author(s) 2015.

  16. Narrative inquiry: a relational research methodology for medical education.

    Science.gov (United States)

    Clandinin, D Jean; Cave, Marie T; Berendonk, Charlotte

    2017-01-01

    Narrative research, an inclusive term for a range of methodologies, has rapidly become part of medical education scholarship. In this paper we identify narrative inquiry as a particular theoretical and methodological framework within narrative research and outline its characteristics. We briefly summarise how narrative research has been used in studying medical learners' identity making in medical education. We then turn to the uses of narrative inquiry in studying medical learners' professional identity making. With the turn to narrative inquiry, the shift is to thinking with stories instead of about stories. We highlight four challenges in engaging in narrative inquiry in medical education and point toward promising future research and practice possibilities. © 2016 John Wiley & Sons Ltd and The Association for the Study of Medical Education.

  17. Identifying the determinants of premature mortality in Russia: overcoming a methodological challenge

    Directory of Open Access Journals (Sweden)

    Leon David A

    2007-11-01

    Full Text Available Abstract Background It is thought that excessive alcohol consumption is related to the high mortality among working age men in Russia. Moreover it has been suggested that alcohol is a key proximate driver of the very sharp fluctuations in mortality seen in this group since the mid-1980s. Designing an individual-level study suitable to address the potential acute effects of alcohol consumption on mortality in Russia has posed a challenge to epidemiologists, especially because of the need to identify factors that could underlie the rapid changes up and down in mortality rates that have been such a distinctive feature of the Russian mortality crisis. In order to address this study question which focuses on exposures acting shortly before sudden death, a cohort would be unfeasibly large and would suffer from recruitment bias. Methods Although the situation in Russia is unusual, with a very high death rate characterised by many sudden and apparently unexpected deaths in young men, the methodological problem is common to research on any cause of death where many deaths are sudden. Results We describe the development of an innovative approach that has overcome some of these challenges: a case-control study employing proxy informants and external data sources to collect information about proximate determinants of mortality. Conclusion This offers a set of principles that can be adopted by epidemiologists studying sudden and unexpected deaths in other settings.

  18. Heterogeneous Effects in Education: The Promise and Challenge of Incorporating Intersectionality into Quantitative Methodological Approaches

    Science.gov (United States)

    Schudde, Lauren

    2018-01-01

    To date, the theory of intersectionality has largely guided qualitative efforts in social science and education research. Translating the construct to new methodological approaches is inherently complex and challenging, but offers the possibility of breaking down silos that keep education researchers with similar interests--but different…

  19. Tough Teens: The Methodological Challenges of Interviewing Teenagers as Research Participants

    Science.gov (United States)

    Bassett, Raewyn; Beagan, Brenda L.; Ristovski-Slijepcevic, Svetlana; Chapman, Gwen E.

    2008-01-01

    Encouraging a teenager to have a conversation in a semistructured research interview is fraught with difficulties. The authors discuss the methodological challenges encountered when interviewing adolescents of European Canadian, African Canadian, and Punjabi Canadian families who took part in the Family Food Decision-Making Study in two regions of…

  20. The Psychological Study of Video Game Players: Methodological Challenges and Practical Advice

    Science.gov (United States)

    King, Daniel; Delfabbro, Paul; Griffiths, Mark

    2009-01-01

    Video game playing has received increased academic interest over the last few decades, particularly with regard to the psychological understanding of addiction. Based on the many studies carried out by the authors, this paper summarises some of the methodological challenges which may arise when studying video game players, including obstacles…

  1. Researching local sports initiatives for young migrants from a political perspective: methodological and practical challenges

    Directory of Open Access Journals (Sweden)

    Noemi García-Arjona

    2017-11-01

    Full Text Available The processes of incorporation of young migrants have been studied using a range of new approaches. Among them, sports and physical activity have been claimed as a space for social and cultural integration. To date, most research has been based mainly on ethnographic and grassroots perspectives to better understand the experiences of sports practices of migrants and their families. However, fewer contributions have focused on the political discourse on sports as a field of integration. This article explores methodological challenges arosen when choosing sports policies as a field of study. The main methodological challenges considered include the contested conceptualizations of the target population in sports initiatives and the development of comparative selection criteria for different levels of institutional participants. An indepth analysis of these methodological issues can help to reflect on the ideological constructs of sports as a field of integration and highlight the contribution of the political sociological perspective to existing migration studies.

  2. Researching health inequalities with Community Researchers: practical, methodological and ethical challenges of an 'inclusive' research approach.

    Science.gov (United States)

    Salway, Sarah; Chowbey, Punita; Such, Elizabeth; Ferguson, Beverly

    2015-01-01

    draw on the experiences of 12 CRs. Two sets of data were generated, analysed and integrated: debriefing/active reflection exercises throughout the 18-month research process and individual qualitative interviews with CRs, conducted at the end of the project ( n  = 9). Data were organised using NVivo10 and coded line-by-line using a framework developed iteratively. Synthesis and interpretation were achieved through a series of reflective team exercises involving input from 4 of the CRs. Final consolidation of key themes was conducted by SS and ES. Results Being an 'insider' to the communities brought distinct advantages to the research process but also generated complexities. CRs highlighted how 'something would be lost' without their involvement but still faced challenges in gathering and analysing data. Some CRs found it difficult to practice reflexivity, and problems of ethnic stereotyping were revealed. Conflict between roles as community members and investigators was at times problematic. The approach promoted some aspects of personal empowerment, but CRs were frustrated by the limited impact of the research at the local level. Conclusions Working with CRs offers distinct practical, ethical and methodological advantages to public health researchers, but these are limited by a range of challenges related to 'closeness', orthodox research structures and practices and the complexities of dynamic identities. For research of this type to meet its full potential and avoid harm, there is a need for careful support to CRs and long-term engagement between funders, research institutions and communities.

  3. THE CHALLENGE OF KEEPING-UP: CURRENT METHODOLOGIES IN ANALYZING THE STUDENTS RECRUITING AREA BY UNIVERSITIES

    Directory of Open Access Journals (Sweden)

    MĂLĂESCU SIMONA

    2013-11-01

    Full Text Available The challenge of keeping-up: current methodologies in analyzing the students recruiting area by universities. Despite all progress made in the field and in some collateral areas extremely useful methodologically (e.g. the use of GIS, for some countries emerging from communist space methodologically upgrading to the latest advances in modelling and forecast of students recruitment by universities remains a difficult challenge. The analysis and modelling of the geographical area of recruiting students for a particular university represents even for the foreign literature a niche, not necessarily consciously neglected but only reached sidely due, most likely, to ignoring the benefits which the focus of concerns on this aspect would bring into focus and directing more efficiently university marketing efforts. This paper aims precisely to seek, through a meta-analysis of existing literature, disparate developments that led in some form or will allow improved modeling spatial areas of recruitment of students by universities and the challenges and limitations that apply methodological advances the area where universities belonging to the ex-communist involved. Beyond the theoretical benefit from a practical perspective, the meta-analysis aimed at synthesizing elements of good practice that can be applied to the local university system.

  4. Methodological Challenges in Sustainability Science: A Call for Method Plurality, Procedural Rigor and Longitudinal Research

    Directory of Open Access Journals (Sweden)

    Henrik von Wehrden

    2017-02-01

    Full Text Available Sustainability science encompasses a unique field that is defined through its purpose, the problem it addresses, and its solution-oriented agenda. However, this orientation creates significant methodological challenges. In this discussion paper, we conceptualize sustainability problems as wicked problems to tease out the key challenges that sustainability science is facing if scientists intend to deliver on its solution-oriented agenda. Building on the available literature, we discuss three aspects that demand increased attention for advancing sustainability science: 1 methods with higher diversity and complementarity are needed to increase the chance of deriving solutions to the unique aspects of wicked problems; for instance, mixed methods approaches are potentially better suited to allow for an approximation of solutions, since they cover wider arrays of knowledge; 2 methodologies capable of dealing with wicked problems demand strict procedural and ethical guidelines, in order to ensure their integration potential; for example, learning from solution implementation in different contexts requires increased comparability between research approaches while carefully addressing issues of legitimacy and credibility; and 3 approaches are needed that allow for longitudinal research, since wicked problems are continuous and solutions can only be diagnosed in retrospect; for example, complex dynamics of wicked problems play out across temporal patterns that are not necessarily aligned with the common timeframe of participatory sustainability research. Taken together, we call for plurality in methodologies, emphasizing procedural rigor and the necessity of continuous research to effectively addressing wicked problems as well as methodological challenges in sustainability science.

  5. Ethical challenges facing veterinary professionals in Ireland: results from Policy Delphi with vignette methodology

    Science.gov (United States)

    Magalhães-Sant'Ana, M.; More, S. J.; Morton, D. B.; Hanlon, A.

    2016-01-01

    Ethics is key to the integrity of the veterinary profession. Despite its importance, there is a lack of applied research on the range of ethical challenges faced by veterinarians. A three round Policy Delphi with vignette methodology was used to record the diversity of views on ethical challenges faced by veterinary professionals in Ireland. Forty experts, comprising veterinary practitioners, inspectors and nurses, accepted to participate. In round 1, twenty vignettes describing a variety of ethically challenging veterinary scenarios were ranked in terms of ethical acceptability, reputational risk and perceived standards of practice. Round 2 aimed at characterising challenges where future policy development or professional guidance was deemed to be needed. In round 3, possible solutions to key challenges were explored. Results suggest that current rules and regulations are insufficient to ensure best veterinary practices and that a collective approach is needed to harness workable solutions for the identified ethical challenges. Challenges pertaining mostly to the food chain seem to require enforcement measures whereas softer measures that promote professional discretion were preferred to address challenges dealing with veterinary clinical services. These findings can support veterinary representative bodies, advisory committees and regulatory authorities in their decision making, policy and regulation. PMID:27613779

  6. Assessing the comparative effectiveness of newly marketed medications: methodological challenges and implications for drug development.

    Science.gov (United States)

    Schneeweiss, S; Gagne, J J; Glynn, R J; Ruhl, M; Rassen, J A

    2011-12-01

    Comparative-effectiveness research (CER) aims to produce actionable evidence regarding the effectiveness and safety of medical products and interventions as they are used outside of controlled research settings. Although CER evidence regarding medications is particularly needed shortly after market approval, key methodological challenges include (i) potential bias due to channeling of patients to the newly marketed medication because of various patient-, physician-, and system-related factors; (ii) rapid changes in the characteristics of the user population during the early phase of marketing; and (iii) lack of timely data and the often small number of users in the first few months of marketing. We propose a mix of approaches to generate comparative-effectiveness data in the early marketing period, including sequential cohort monitoring with secondary health-care data and propensity score (PS) balancing, as well as extended follow-up of phase III and phase IV trials, indirect comparisons of placebo-controlled trials, and modeling and simulation of virtual trials.

  7. Post-Traumatic Stress Symptoms in Post-ICU Family Members: Review and Methodological Challenges.

    Science.gov (United States)

    Petrinec, Amy B; Daly, Barbara J

    2016-01-01

    Family members of intensive care unit (ICU) patients are at risk for symptoms of post-traumatic stress disorder (PTSD) following ICU discharge. The aim of this systematic review is to examine the current literature regarding post-ICU family PTSD symptoms with an emphasis on methodological issues in conducting research on this challenging phenomenon. An extensive review of the literature was performed confining the search to English language studies reporting PTSD symptoms in adult family members of adult ICU patients. Ten studies were identified for review published from 2004 to 2012. Findings demonstrate a significant prevalence of family PTSD symptoms in the months following ICU hospitalization. However, there are several methodological challenges to the interpretation of existing studies and to the conduct of future research including differences in sampling, identification of risk factors and covariates of PTSD, and lack of consensus regarding the most appropriate PTSD symptom measurement tools and timing. © The Author(s) 2014.

  8. Narrative inquiry: Locating Aboriginal epistemology in a relational methodology.

    Science.gov (United States)

    Barton, Sylvia S

    2004-03-01

    This methodology utilizes narrative analysis and the elicitation of life stories as understood through dimensions of interaction, continuity, and situation. It is congruent with Aboriginal epistemology formulated by oral narratives through representation, connection, storytelling and art. Needed for culturally competent scholarship is an experience of research whereby inquiry into epiphanies, ritual, routines, metaphors and everyday experience creates a process of reflexive thinking for multiple ways of knowing. Based on the sharing of perspectives, narrative inquiry allows for experimentation into creating new forms of knowledge by contextualizing diabetes from the experience of a researcher overlapped with experiences of participants--a reflective practice in itself. The aim of this paper is to present narrative inquiry as a relational methodology and to analyse critically its appropriateness as an innovative research approach for exploring Aboriginal people's experience living with diabetes. Narrative inquiry represents an alternative culture of research for nursing science to generate understanding and explanation of Aboriginal people's 'diabetic self' stories, and to coax open a window for co-constructing a narrative about diabetes as a chronic illness. The ability to adapt a methodology for use in a cultural context, preserve the perspectives of Aboriginal peoples, maintain the holistic nature of social problems, and value co-participation in respectful ways are strengths of an inquiry partial to a responsive and embodied scholarship.

  9. Methodological Challenges in Estimating Trends and Burden of Cardiovascular Disease in Sub-Saharan Africa

    Directory of Open Access Journals (Sweden)

    Jacob K. Kariuki

    2015-01-01

    Full Text Available Background. Although 80% of the burden of cardiovascular disease (CVD is in developing countries, the 2010 global burden of disease (GBD estimates have been cited to support a premise that sub-Saharan Africa (SSA is exempt from the CVD epidemic sweeping across developing countries. The widely publicized perspective influences research priorities and resource allocation at a time when secular trends indicate a rapid increase in prevalence of CVD in SSA by 2030. Purpose. To explore methodological challenges in estimating trends and burden of CVD in SSA via appraisal of the current CVD statistics and literature. Methods. This review was guided by the Critical review methodology described by Grant and Booth. The review traces the origins and evolution of GBD metrics and then explores the methodological limitations inherent in the current GBD statistics. Articles were included based on their conceptual contribution to the existing body of knowledge on the burden of CVD in SSA. Results/Conclusion. Cognizant of the methodological challenges discussed, we caution against extrapolation of the global burden of CVD statistics in a way that underrates the actual but uncertain impact of CVD in SSA. We conclude by making a case for optimal but cost-effective surveillance and prevention of CVD in SSA.

  10. Challenges and Opportunities for Harmonizing Research Methodology: Raw Accelerometry.

    Science.gov (United States)

    van Hees, Vincent T; Thaler-Kall, Kathrin; Wolf, Klaus-Hendrik; Brønd, Jan C; Bonomi, Alberto; Schulze, Mareike; Vigl, Matthäus; Morseth, Bente; Hopstock, Laila Arnesdatter; Gorzelniak, Lukas; Schulz, Holger; Brage, Søren; Horsch, Alexander

    2016-12-07

    Raw accelerometry is increasingly being used in physical activity research, but diversity in sensor design, attachment and signal processing challenges the comparability of research results. Therefore, efforts are needed to harmonize the methodology. In this article we reflect on how increased methodological harmonization may be achieved. The authors of this work convened for a two-day workshop (March 2014) themed on methodological harmonization of raw accelerometry. The discussions at the workshop were used as a basis for this review. Key stakeholders were identified as manufacturers, method developers, method users (application), publishers, and funders. To facilitate methodological harmonization in raw accelerometry the following action points were proposed: i) Manufacturers are encouraged to provide a detailed specification of their sensors, ii) Each fundamental step of algorithms for processing raw accelerometer data should be documented, and ideally also motivated, to facilitate interpretation and discussion, iii) Algorithm developers and method users should be open about uncertainties in the description of data and the uncertainty of the inference itself, iv) All new algorithms which are pitched as "ready for implementation" should be shared with the community to facilitate replication and ongoing evaluation by independent groups, and v) A dynamic interaction between method stakeholders should be encouraged to facilitate a well-informed harmonization process. The workshop led to the identification of a number of opportunities for harmonizing methodological practice. The discussion as well as the practical checklists proposed in this review should provide guidance for stakeholders on how to contribute to increased harmonization.

  11. Methodological challenges of optical tweezers-based X-ray fluorescence imaging of biological model organisms at synchrotron facilities.

    Science.gov (United States)

    Vergucht, Eva; Brans, Toon; Beunis, Filip; Garrevoet, Jan; Bauters, Stephen; De Rijcke, Maarten; Deruytter, David; Janssen, Colin; Riekel, Christian; Burghammer, Manfred; Vincze, Laszlo

    2015-07-01

    Recently, a radically new synchrotron radiation-based elemental imaging approach for the analysis of biological model organisms and single cells in their natural in vivo state was introduced. The methodology combines optical tweezers (OT) technology for non-contact laser-based sample manipulation with synchrotron radiation confocal X-ray fluorescence (XRF) microimaging for the first time at ESRF-ID13. The optical manipulation possibilities and limitations of biological model organisms, the OT setup developments for XRF imaging and the confocal XRF-related challenges are reported. In general, the applicability of the OT-based setup is extended with the aim of introducing the OT XRF methodology in all research fields where highly sensitive in vivo multi-elemental analysis is of relevance at the (sub)micrometre spatial resolution level.

  12. Methodological challenges in assessing the environmental status of a marine ecosystem: case study of the Baltic Sea.

    Directory of Open Access Journals (Sweden)

    Henn Ojaveer

    Full Text Available Assessments of the environmental status of marine ecosystems are increasingly needed to inform management decisions and regulate human pressures to meet the objectives of environmental policies. This paper addresses some generic methodological challenges and related uncertainties involved in marine ecosystem assessment, using the central Baltic Sea as a case study. The objectives of good environmental status of the Baltic Sea are largely focusing on biodiversity, eutrophication and hazardous substances. In this paper, we conduct comparative evaluations of the status of these three segments, by applying different methodological approaches. Our analyses indicate that the assessment results are sensitive to a selection of indicators for ecological quality objectives that are affected by a broad spectrum of human activities and natural processes (biodiversity, less so for objectives that are influenced by a relatively narrow array of drivers (eutrophications, hazardous substances. The choice of indicator aggregation rule appeared to be of essential importance for assessment results for all three segments, whereas the hierarchical structure of indicators had only a minor influence. Trend-based assessment was shown to be a useful supplement to reference-based evaluation, being independent of the problems related to defining reference values and indicator aggregation methodologies. Results of this study will help in setting priorities for future efforts to improve environmental assessments in the Baltic Sea and elsewhere, and to ensure the transparency of the assessment procedure.

  13. Methodological Challenges in Studies Comparing Prehospital Advanced Life Support with Basic Life Support.

    Science.gov (United States)

    Li, Timmy; Jones, Courtney M C; Shah, Manish N; Cushman, Jeremy T; Jusko, Todd A

    2017-08-01

    Determining the most appropriate level of care for patients in the prehospital setting during medical emergencies is essential. A large body of literature suggests that, compared with Basic Life Support (BLS) care, Advanced Life Support (ALS) care is not associated with increased patient survival or decreased mortality. The purpose of this special report is to synthesize the literature to identify common study design and analytic challenges in research studies that examine the effect of ALS, compared to BLS, on patient outcomes. The challenges discussed in this report include: (1) choice of outcome measure; (2) logistic regression modeling of common outcomes; (3) baseline differences between study groups (confounding); (4) inappropriate statistical adjustment; and (5) inclusion of patients who are no longer at risk for the outcome. These challenges may affect the results of studies, and thus, conclusions of studies regarding the effect of level of prehospital care on patient outcomes should require cautious interpretation. Specific alternatives for avoiding these challenges are presented. Li T , Jones CMC , Shah MN , Cushman JT , Jusko TA . Methodological challenges in studies comparing prehospital Advanced Life Support with Basic Life Support. Prehosp Disaster Med. 2017;32(4):444-450.

  14. Recommendations related to the strategic environmental assessment. Methodological note

    International Nuclear Information System (INIS)

    Le Bris, Charlotte; Brivadier, Isabelle; Fournie, Sebastien; Godart, Angelique; Hubert, Severine; Ille, Yann-Mikiel; Le Mitouard, Eric; Phelep, Michele; Delduc, Paul; Poitevin, Florent; Lemaitre, Valery; Bataille, Tristan; Noulin, Alice; Fevre, Cecile; Kervella, Frederic; Orefici, Christine; Rambaud, Lucile; Antoine, Stephanie; Wormser, Veronique; Garrigou, Olivier; Vinay, Catherine; Cretin, Benedicte; Le Saout, Michaele; Pagnucco, Fabrice; Meinier, Yves; Nicolas, Veronique; Thiolliere, Blandine; Guilbert, Sebastien; Billant, Claude; Saingenest, Patrick

    2015-05-01

    This methodological note aims at giving commissioners and project managers of plans, schemes and programmes or other planning documents related to strategic environmental assessment a comprehensive vision of the approach to be adopted, as well as useful advices and operational recommendations. The first part recalls the main principles of environmental assessment, addresses general issues of organisation of the approach, and clarifies its articulation with the plan/scheme/programme elaboration or other approaches such as the assessment of incidences on the Natura 2000 network. The second part addresses the different chapters which are foreseen by the regulation for the environmental report. Some sheets are proposed on SDAGEs (Water Development and Management Master Plans) and PGIRs (flood risk management plans), on SRCs (quarry regional plan) and SAGEs (Water Development and Management Scheme)

  15. Safety-related operator actions: methodology for developing criteria

    International Nuclear Information System (INIS)

    Kozinsky, E.J.; Gray, L.H.; Beare, A.N.; Barks, D.B.; Gomer, F.E.

    1984-03-01

    This report presents a methodology for developing criteria for design evaluation of safety-related actions by nuclear power plant reactor operators, and identifies a supporting data base. It is the eleventh and final NUREG/CR Report on the Safety-Related Operator Actions Program, conducted by Oak Ridge National Laboratory for the US Nuclear Regulatory Commission. The operator performance data were developed from training simulator experiments involving operator responses to simulated scenarios of plant disturbances; from field data on events with similar scenarios; and from task analytic data. A conceptual model to integrate the data was developed and a computer simulation of the model was run, using the SAINT modeling language. Proposed is a quantitative predictive model of operator performance, the Operator Personnel Performance Simulation (OPPS) Model, driven by task requirements, information presentation, and system dynamics. The model output, a probability distribution of predicted time to correctly complete safety-related operator actions, provides data for objective evaluation of quantitative design criteria

  16. Addressing the Challenges Related to Transforming Qualitative Into Quantitative Data in Qualitative Comparative Analysis

    NARCIS (Netherlands)

    Block, de Debora; Vis, Barbara

    2018-01-01

    The use of qualitative data has so far received relatively little attention in methodological discussions on qualitative comparative analysis (QCA). This article addresses this lacuna by discussing the challenges researchers face when transforming qualitative data into quantitative data in QCA. By

  17. Methodological Challenges in Examining the Impact of Healthcare Predictive Analytics on Nursing-Sensitive Patient Outcomes.

    Science.gov (United States)

    Jeffery, Alvin D

    2015-06-01

    The expansion of real-time analytic abilities within current electronic health records has led to innovations in predictive modeling and clinical decision support systems. However, the ability of these systems to influence patient outcomes is currently unknown. Even though nurses are the largest profession within the healthcare workforce, little research has been performed to explore the impact of clinical decision support on their decisions and the patient outcomes associated with them. A scoping literature review explored the impact clinical decision support systems containing healthcare predictive analytics have on four nursing-sensitive patient outcomes (pressure ulcers, failure to rescue, falls, and infections). While many articles discussed variable selection and predictive model development/validation, only four articles examined the impact on patient outcomes. The novelty of predictive analytics and the inherent methodological challenges in studying clinical decision support impact are likely responsible for this paucity of literature. Major methodological challenges include (1) multilevel nature of intervention, (2) treatment fidelity, and (3) adequacy of clinicians' subsequent behavior. There is currently insufficient evidence to demonstrate efficacy of healthcare predictive analytics-enhanced clinical decision support systems on nursing-sensitive patient outcomes. Innovative research methods and a greater emphasis on studying this phenomenon are needed.

  18. On the Methodology of Research of Sunni-Shiite Relations

    Directory of Open Access Journals (Sweden)

    Olga Sergeevna Chikrizova

    2015-12-01

    Full Text Available The article is devoted to methodological aspects of analysis of confrontation between two biggest trends in Islam - Sunnism and Shiism. It’s extremely important to study Sunni-Shiite relations on the modern stage because they reflect geopolitical and geostrategic rivalry in the region and change of interstate alliances’ configuration. After “the Arab spring” in the Middle East some conflicts have flared up (Iraq, Syria, Yemen, and one of the reasons of all the conflicts is a confrontation between Sunnis and Shiites. Moreover, some more hot spots are brewing, in which the representatives of two major trends in Islam will face (Lebanon, Saudi Arabia, Bahrain. In order to find ways to settle these conflicts we need to learn profoundly the origins, nature and characteristics of Sunni-Shiite relations, and it also determines the relevance of this article’s topic. Using comparative method, historicism, problem-chronological method and quantitative methods of analysis, the author indicates six periods of Sunni-Shiite antagonism, during which the contradictions between two trends had gradually shifted from domestic to international level, and then to global level. Comparing foreign policy practice of Sunni and Shiite states at the present stage, the author proves that nowadays the struggle between Sunnis and Shiites for the implementation of models of the Islamic world’s development takes place. These models are global, they are aimed at the unification of the Islamic world. However they are based on completely different visions of this world’s configuration, particularly in the region of the Middle East.

  19. Relational information in medicine: a challenge

    International Nuclear Information System (INIS)

    Bolboaca, S.; Cadariu, A.; Jaentschi, L.

    2005-01-01

    Nowadays, a sizable amount of information is available in all areas medical domain including radiology. An important provocation is represented by the organization of these huge amounts of medical information, tasks that are essential in order to be used. The present paper presents a proposal of a relational structure for the organization of medical information using key terms and a Visual Fox Pro application for structure management

  20. Unsolicited written narratives as a methodological genre in terminal illness: challenges and limitations.

    Science.gov (United States)

    O'Brien, Mary R; Clark, David

    2012-02-01

    Stories about illness have proven invaluable in helping health professionals understand illness experiences. Such narratives have traditionally been solicited by researchers through interviews and the collection of personal writings, including diaries. These approaches are, however, researcher driven; the impetus for the creation of the story comes from the researcher and not the narrator. In recent years there has been exponential growth in illness narratives created by individuals, of their own volition, and made available for others to read in print or as Internet accounts. We sought to determine whether it was possible to identify such material for use as research data to explore the subject of living with the terminal illness amyotrophic lateral sclerosis/motor neuron disease--the contention being that these accounts are narrator driven and therefore focus on issues of greatest importance to the affected person. We encountered and sought to overcome a number of methodological and ethical challenges, which is our focus here.

  1. Evaluating the effects of the Dietary Guidelines for Americans on consumer behavior and health: methodological challenges.

    Science.gov (United States)

    Guthrie, Joanne F; Smallwood, David M

    2003-12-01

    The Dietary Guidelines for Americans is the official nutrition policy statement for the United States. Government involvement in providing information on private behavior, such as food choice, is justified by the high cost of poor diets, as measured in medical expenses and lost productivity. The Guidelines are intended to provide an up-to-date, consistent information base for federal nutrition education and information efforts and food assistance program regulations. Through these policy mechanisms, the Guidelines are assumed to improve dietary behavior, and, ultimately, health. By law, the Dietary Guidelines for Americans must be updated every five years; however, there is no mandate for evaluation. Evaluation could provide useful information to assess the extent to which the Guidelines positively influence health and provide insights into reasons for their successes and limitations. However, evaluation would also present considerable challenges. This paper discusses the critical data and methodological needs for improving evaluation of the Dietary Guidelines for Americans.

  2. Dialysis-related amyloidosis: challenges and solutions

    Directory of Open Access Journals (Sweden)

    Scarpioni R

    2016-12-01

    Full Text Available R Scarpioni, M Ricardi, V Albertazzi, S De Amicis, F Rastelli, L Zerbini Department of Nephrology and Dialysis, Azienda Unità Sanitaria Local (AUSL Hospital “Guglielmo da Saliceto”, Piacenza, Italy Abstract: Amyloidosis refers to the extracellular tissue deposition of fibrils composed of low-molecular-weight subunits of a variety of proteins. These deposits may result in a wide range of clinical manifestations depending upon their type, location, and the amount of deposition. Dialysis-related amyloidosis is a serious complication of long-term dialysis therapy and is characterized by the deposition of amyloid fibrils, principally composed of β2 microglobulins (β2M, in the osteoarticular structures and viscera. Most of the β2M is eliminated through glomerular filtration and subsequent reabsorption and catabolism by the proximal tubules. As a consequence, the serum levels of β2M are inversely related to the glomerular filtration rate; therefore, in end-stage renal disease patients, β2M levels increase up to 60-fold. Serum levels of β2M are also elevated in several pathological conditions such as chronic inflammation, liver disease, and above all, in renal dysfunction. Retention of amyloidogenic protein has been attributed to several factors including type of dialysis membrane, prolonged uremic state and/or decreased diuresis, advanced glycation end products, elevated levels of cytokines and dialysate. Dialysis treatment per se has been considered to be an inflammatory stimulus, inducing cytokine production (such as interleukin-1, tumor necrosis factor-α, interleukin-6 and complement activation. The released cytokines are thought to stimulate the synthesis and release of β2M by the macrophages and/or augment the expression of human leukocyte antigens (class I, increasing β2M expression. Residual renal function is probably the best determinant of β2M levels. Therefore, it has to be maintained as long as possible. In this article

  3. A review on human reinstatement studies: an overview and methodological challenges.

    Science.gov (United States)

    Haaker, Jan; Golkar, Armita; Hermans, Dirk; Lonsdorf, Tina B

    2014-09-01

    In human research, studies of return of fear (ROF) phenomena, and reinstatement in particular, began only a decade ago and recently are more widely used, e.g., as outcome measures for fear/extinction memory manipulations (e.g., reconsolidation). As reinstatement research in humans is still in its infancy, providing an overview of its stability and boundary conditions and summarizing methodological challenges is timely to foster fruitful future research. As a translational endeavor, clarifying the circumstances under which (experimental) reinstatement occurs may offer a first step toward understanding relapse as a clinical phenomenon and pave the way for the development of new pharmacological or behavioral ways to prevent ROF. The current state of research does not yet allow pinpointing these circumstances in detail and we hope this review will aid the research field to advance in this direction. As an introduction, we begin with a synopsis of rodent work on reinstatement and theories that have been proposed to explain the findings. The review however mainly focuses on reinstatement in humans. We first describe details and variations of the experimental setup in reinstatement studies in humans and give a general overview of results. We continue with a compilation of possible experimental boundary conditions and end with the role of individual differences and behavioral and/or pharmacological manipulations. Furthermore, we compile important methodological and design details on the published studies in humans and end with open research questions and some important methodological and design recommendations as a guide for future research. © 2014 Haaker et al.; Published by Cold Spring Harbor Laboratory Press.

  4. Metabolic consequences of obesity and insulin resistance in polycystic ovary syndrome: diagnostic and methodological challenges.

    Science.gov (United States)

    Jeanes, Yvonne M; Reeves, Sue

    2017-06-01

    Women with polycystic ovary syndrome (PCOS) have a considerable risk of metabolic dysfunction. This review aims to present contemporary knowledge on obesity, insulin resistance and PCOS with emphasis on the diagnostic and methodological challenges encountered in research and clinical practice. Variable diagnostic criteria for PCOS and associated phenotypes are frequently published. Targeted searches were conducted to identify all available data concerning the association of obesity and insulin resistance with PCOS up to September 2016. Articles were considered if they were peer reviewed, in English and included women with PCOS. Obesity is more prevalent in women with PCOS, but studies rarely reported accurate assessments of adiposity, nor split the study population by PCOS phenotypes. Many women with PCOS have insulin resistance, though there is considerable variation reported in part due to not distinguishing subgroups known to have an impact on insulin resistance as well as limited methodology to measure insulin resistance. Inflammatory markers are positively correlated with androgen levels, but detailed interactions need to be identified. Weight management is the primary therapy; specific advice to reduce the glycaemic load of the diet and reduce the intake of pro-inflammatory SFA and advanced glycation endproducts have provided promising results. It is important that women with PCOS are educated about their increased risk of metabolic complications in order to make timely and appropriate lifestyle modifications. Furthermore, well-designed robust studies are needed to evaluate the mechanisms behind the improvements observed with dietary interventions.

  5. Conceptual and methodological challenges to integrating SEA and cumulative effects assessment

    International Nuclear Information System (INIS)

    Gunn, Jill; Noble, Bram F.

    2011-01-01

    The constraints to assessing and managing cumulative environmental effects in the context of project-based environmental assessment are well documented, and the potential benefits of a more strategic approach to cumulative effects assessment (CEA) are well argued; however, such benefits have yet to be clearly demonstrated in practice. While it is widely assumed that cumulative effects are best addressed in a strategic context, there has been little investigation as to whether CEA and strategic environmental assessment (SEA) are a 'good fit' - conceptually or methodologically. This paper identifies a number of conceptual and methodological challenges to the integration of CEA and SEA. Based on results of interviews with international experts and practitioners, this paper demonstrates that: definitions and conceptualizations of CEA are typically weak in practice; approaches to effects aggregation vary widely; a systems perspective lacks in both SEA and CEA; the multifarious nature of SEA complicates CEA; tiering arrangements between SEA and project-based assessment are limited to non-existing; and the relationship of SEA to regional planning remains unclear.

  6. Methodological challenges in measurements of functional ability in gerontological research. A review

    DEFF Research Database (Denmark)

    Avlund, Kirsten

    1997-01-01

    This article addresses two important challenges in the measurement of functional ability in gerontological research: the first challenge is to connect measurements to a theoretical frame of reference which enhances our understanding and interpretation of the collected data; the second relates...... procedure, validity, discriminatory power, and responsiveness. In measures of functional ability it is recommended: 1) always to consider the theoretical frame of reference as part of the validation process (e.g., the theory of "The Disablement Process"; 2) always to assess whether the included activities...

  7. Methodological challenges in a study on falls in an older population of Cape Town, South Africa.

    Science.gov (United States)

    Kalula, Sebastiana Z; Ferreira, Monica; Swingler, George H; Badri, Motasim; Sayer, Avan A

    2017-09-01

    Falls are a major cause of disability, morbidity and mortality in older persons, but have been under researched in developing countries. To describe challenges encountered in a community-based study on falls in a multi-ethnic population aged ≥65 years in a low-income setting. The study was conducted in four stages: A pilot study (n=105) to establish a sample size for the survey. An equipment validation study (n=118) to use for fall risk determination. A cross-sectional baseline (n=837) and a 12-month follow-up survey (n=632) to establish prevalence and risk factors for falls. Prevalence rate of 26.4% (95% CI 23.5-29.5%) and risk factors for recurrent falls: previous falls, self-reported poor mobility and dizziness were established. Adaptations to the gold standard prospective fall research study design were employed: 1) to gain access to the study population in three selected suburbs, 2) to perform assessments in a non-standardised setting, 3) to address subjects' poverty and low literacy levels, and high attrition of subjects and field workers. Studies on falls in the older population of low- to middle-income countries have methodological challenges. Adaptive strategies used in the Cape Town study and the research experience reported may be instructive for investigators planning similar studies in such settings.

  8. Estimating small area health-related characteristics of populations: a methodological review

    Directory of Open Access Journals (Sweden)

    Azizur Rahman

    2017-05-01

    Full Text Available Estimation of health-related characteristics at a fine local geographic level is vital for effective health promotion programmes, provision of better health services and population-specific health planning and management. Lack of a micro-dataset readily available for attributes of individuals at small areas negatively impacts the ability of local and national agencies to manage serious health issues and related risks in the community. A solution to this challenge would be to develop a method that simulates reliable small-area statistics. This paper provides a significant appraisal of the methodologies for estimating health-related characteristics of populations at geographical limited areas. Findings reveal that a range of methodologies are in use, which can be classified as three distinct set of approaches: i indirect standardisation and individual level modelling; ii multilevel statistical modelling; and iii micro-simulation modelling. Although each approach has its own strengths and weaknesses, it appears that microsimulation- based spatial models have significant robustness over the other methods and also represent a more precise means of estimating health-related population characteristics over small areas.

  9. Conceptual and methodological challenges for neuroimaging studies of autistic spectrum disorders

    Directory of Open Access Journals (Sweden)

    Mazzone Luigi

    2010-03-01

    Full Text Available Abstract Autistic Spectrum Disorders (ASDs are a set of complex developmental disabilities defined by impairment in social interaction and communication, as well as by restricted interests or repetitive behaviors. Neuroimaging studies have substantially advanced our understanding of the neural mechanisms that underlie the core symptoms of ASDs. Nevertheless, a number of challenges still remain in the application of neuroimaging techniques to the study of ASDs. We review three major conceptual and methodological challenges that complicate the interpretation of findings from neuroimaging studies in ASDs, and that future imaging studies should address through improved designs. These include: (1 identification and implementation of tasks that more specifically target the neural processes of interest, while avoiding the confusion that the symptoms of ASD may impose on both the performance of the task and the detection of brain activations; (2 the inconsistency that disease heterogeneity in persons with ASD can generate on research findings, particularly heterogeneity of symptoms, symptom severity, differences in IQ, total brain volume, and psychiatric comorbidity; and (3 the problems with interpretation of findings from cross-sectional studies of persons with ASD across differing age groups. Failure to address these challenges will continue to hinder our ability to distinguish findings that outline the causes of ASDs from brain processes that represent downstream or compensatory responses to the presence of the disease. Here we propose strategies to address these issues: 1 the use of simple and elementary tasks, that are easier to understand for autistic subjects; 2 the scanning of a more homogenous group of persons with ASDs, preferably at younger age; 3 the performance of longitudinal studies, that may provide more straight forward and reliable results. We believe that this would allow for a better understanding of both the central pathogenic

  10. Methodological Issues in HIV-Related Social Research in Nigeria

    African Journals Online (AJOL)

    AJRH Managing Editor

    Methodological Issues in HIV/AIDS Social Research in Nigeria ... convaincue au commencement de l'étude qu'une étude sur l'interaction entre le VIH/sida et les questions sensibles comme les ..... One of the vexed issues was the requirement.

  11. Economic relations between turkey and Africa: challenges and ...

    African Journals Online (AJOL)

    Economic relations between turkey and Africa: challenges and prospects. ... The incumbent Turkish government now attaches great importance to developing ... It also seeks to analyse recent Turkish initiatives in Africa's energy sector.

  12. Laboratory methodologies for indicators of iron status: strengths, limitations, and analytical challenges.

    Science.gov (United States)

    Pfeiffer, Christine M; Looker, Anne C

    2017-12-01

    Biochemical assessment of iron status relies on serum-based indicators, such as serum ferritin (SF), transferrin saturation, and soluble transferrin receptor (sTfR), as well as erythrocyte protoporphyrin. These indicators present challenges for clinical practice and national nutrition surveys, and often iron status interpretation is based on the combination of several indicators. The diagnosis of iron deficiency (ID) through SF concentration, the most commonly used indicator, is complicated by concomitant inflammation. sTfR concentration is an indicator of functional ID that is not an acute-phase reactant, but challenges in its interpretation arise because of the lack of assay standardization, common reference ranges, and common cutoffs. It is unclear which indicators are best suited to assess excess iron status. The value of hepcidin, non-transferrin-bound iron, and reticulocyte indexes is being explored in research settings. Serum-based indicators are generally measured on fully automated clinical analyzers available in most hospitals. Although international reference materials have been available for years, the standardization of immunoassays is complicated by the heterogeneity of antibodies used and the absence of physicochemical reference methods to establish "true" concentrations. From 1988 to 2006, the assessment of iron status in NHANES was based on the multi-indicator ferritin model. However, the model did not indicate the severity of ID and produced categorical estimates. More recently, iron status assessment in NHANES has used the total body iron stores (TBI) model, in which the log ratio of sTfR to SF is assessed. Together, sTfR and SF concentrations cover the full range of iron status. The TBI model better predicts the absence of bone marrow iron than SF concentration alone, and TBI can be analyzed as a continuous variable. Additional consideration of methodologies, interpretation of indicators, and analytic standardization is important for further

  13. Investigating DMOs through the Lens of Social Network Analysis: Theoretical Gaps, Methodological Challenges and Practitioner Perspectives

    Directory of Open Access Journals (Sweden)

    Dean HRISTOV

    2015-06-01

    Full Text Available The extant literature on networks in tourism management research has traditionally acknowledged destinations as the primary unit of analysis. This paper takes an alternative perspective and positions Destination Management Organisations (DMOs at the forefront of today’s tourism management research agenda. Whilst providing a relatively structured approach to generating enquiry, network research vis-à-vis Social Network Analysis (SNA in DMOs is often surrounded by serious impediments. Embedded in the network literature, this conceptual article aims to provide a practitioner perspective on addressing the obstacles to undertaking network studies in DMO organisations. A simple, three-step methodological framework for investigating DMOs as interorganisational networks of member organisations is proposed in response to complexities in network research. The rationale behind introducing such framework lies in the opportunity to trigger discussions and encourage further academic contributions embedded in both theory and practice. Academic and practitioner contributions are likely to yield insights into the importance of network methodologies applied to DMO organisations.

  14. Progress and challenges in the development and qualification of multi-level multi-physics coupled methodologies for reactor analysis

    International Nuclear Information System (INIS)

    Ivanov, K.; Avramova, M.

    2007-01-01

    Current trends in nuclear power generation and regulation as well as the design of next generation reactor concepts along with the continuing computer technology progress stimulate the development, qualification and application of multi-physics multi-scale coupled code systems. The efforts have been focused on extending the analysis capabilities by coupling models, which simulate different phenomena or system components, as well as on refining the scale and level of detail of the coupling. This paper reviews the progress made in this area and outlines the remaining challenges. The discussion is illustrated with examples based on neutronics/thermohydraulics coupling in the reactor core modeling. In both fields recent advances and developments are towards more physics-based high-fidelity simulations, which require implementation of improved and flexible coupling methodologies. First, the progresses in coupling of different physics codes along with the advances in multi-level techniques for coupled code simulations are discussed. Second, the issues related to the consistent qualification of coupled multi-physics and multi-scale code systems for design and safety evaluation are presented. The increased importance of uncertainty and sensitivity analysis are discussed along with approaches to propagate the uncertainty quantification between the codes. The incoming OECD LWR Uncertainty Analysis in Modeling (UAM) benchmark is the first international activity to address this issue and it is described in the paper. Finally, the remaining challenges with multi-physics coupling are outlined. (authors)

  15. Progress and challenges in the development and qualification of multi-level multi-physics coupled methodologies for reactor analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ivanov, K.; Avramova, M. [Pennsylvania State Univ., University Park, PA (United States)

    2007-07-01

    Current trends in nuclear power generation and regulation as well as the design of next generation reactor concepts along with the continuing computer technology progress stimulate the development, qualification and application of multi-physics multi-scale coupled code systems. The efforts have been focused on extending the analysis capabilities by coupling models, which simulate different phenomena or system components, as well as on refining the scale and level of detail of the coupling. This paper reviews the progress made in this area and outlines the remaining challenges. The discussion is illustrated with examples based on neutronics/thermohydraulics coupling in the reactor core modeling. In both fields recent advances and developments are towards more physics-based high-fidelity simulations, which require implementation of improved and flexible coupling methodologies. First, the progresses in coupling of different physics codes along with the advances in multi-level techniques for coupled code simulations are discussed. Second, the issues related to the consistent qualification of coupled multi-physics and multi-scale code systems for design and safety evaluation are presented. The increased importance of uncertainty and sensitivity analysis are discussed along with approaches to propagate the uncertainty quantification between the codes. The incoming OECD LWR Uncertainty Analysis in Modeling (UAM) benchmark is the first international activity to address this issue and it is described in the paper. Finally, the remaining challenges with multi-physics coupling are outlined. (authors)

  16. Appropriate methodologies for empirical bioethics: it's all relative.

    Science.gov (United States)

    Ives, Jonathan; Draper, Heather

    2009-05-01

    In this article we distinguish between philosophical bioethics (PB), descriptive policy orientated bioethics (DPOB) and normative policy oriented bioethics (NPOB). We argue that finding an appropriate methodology for combining empirical data and moral theory depends on what the aims of the research endeavour are, and that, for the most part, this combination is only required for NPOB. After briefly discussing the debate around the is/ought problem, and suggesting that both sides of this debate are misunderstanding one another (i.e. one side treats it as a conceptual problem, whilst the other treats it as an empirical claim), we outline and defend a methodological approach to NPOB based on work we have carried out on a project exploring the normative foundations of paternal rights and responsibilities. We suggest that given the prominent role already played by moral intuition in moral theory, one appropriate way to integrate empirical data and philosophical bioethics is to utilize empirically gathered lay intuition as the foundation for ethical reasoning in NPOB. The method we propose involves a modification of a long-established tradition on non-intervention in qualitative data gathering, combined with a form of reflective equilibrium where the demands of theory and data are given equal weight and a pragmatic compromise reached.

  17. Methodological challenges to bridge the gap between regional climate and hydrology models

    Science.gov (United States)

    Bozhinova, Denica; José Gómez-Navarro, Juan; Raible, Christoph; Felder, Guido

    2017-04-01

    The frequency and severity of floods worldwide, together with their impacts, are expected to increase under climate change scenarios. It is therefore very important to gain insight into the physical mechanisms responsible for such events in order to constrain the associated uncertainties. Model simulations of the climate and hydrological processes are important tools that can provide insight in the underlying physical processes and thus enable an accurate assessment of the risks. Coupled together, they can provide a physically consistent picture that allows to assess the phenomenon in a comprehensive way. However, climate and hydrological models work at different temporal and spatial scales, so there are a number of methodological challenges that need to be carefully addressed. An important issue pertains the presence of biases in the simulation of precipitation. Climate models in general, and Regional Climate models (RCMs) in particular, are affected by a number of systematic biases that limit their reliability. In many studies, prominently the assessment of changes due to climate change, such biases are minimised by applying the so-called delta approach, which focuses on changes disregarding absolute values that are more affected by biases. However, this approach is not suitable in this scenario, as the absolute value of precipitation, rather than the change, is fed into the hydrological model. Therefore, bias has to be previously removed, being this a complex matter where various methodologies have been proposed. In this study, we apply and discuss the advantages and caveats of two different methodologies that correct the simulated precipitation to minimise differences with respect an observational dataset: a linear fit (FIT) of the accumulated distributions and Quantile Mapping (QM). The target region is Switzerland, and therefore the observational dataset is provided by MeteoSwiss. The RCM is the Weather Research and Forecasting model (WRF), driven at the

  18. Cognitive models of executive functions development: methodological limitations and theoretical challenges

    Directory of Open Access Journals (Sweden)

    Florencia Stelzer

    2014-01-01

    Full Text Available Executive functions (EF have been defined as a series of higher-order cognitive processes which allow the control of thought, behavior and affection according to the achievement of a goal. Such processes present a lengthy postnatal development which matures completely by the end of adolescence. In this article we make a review of some of the main models of EF development during childhood. The aim of this work is to describe the state of the art related to the topic, identifying the main theoretical difficulties and methodological limitations associated with the different proposed paradigms. Finally, some suggestions are given to cope with such difficulties, emphasizing that the development of an ontology of EF could be a viable alternative to counter them. We believe that futture researches should guide their efforts toward the development of that ontology.

  19. Methodological issues related to studies of lead mobilization during menopause

    Directory of Open Access Journals (Sweden)

    Berkowitz Gertrud S.

    1999-01-01

    Full Text Available While there has been a substantial decline in lead exposure in the United States during the past two decades, mobilization of existing lead stored in bone potentially represents an important endogenous source of exposure for menopausal women. It has been hypothesized that lead may be mobilized from skeletal stores during conditions of high bone turnover, such as during menopause. However, such mobilization has not been documented in prospective studies. This discussion is focussed on some of the methodological difficulties to be anticipated in longitudinal studies of lead mobilization specific to menopause and the issues that need to be taken into account when evaluating the results of such studies. To evaluate whether lead mobilization occurs during menopause, a prospective repeated measures design is needed using X-ray fluorescence analysis of lead in bone and serial measurements of blood lead. Potential confounders and effect modifiers also need to be taken into account in the statistical analysis.

  20. Teaching Culture: The Challenges and Opportunities of International Public Relations.

    Science.gov (United States)

    George, Amiso M.

    2003-01-01

    Focuses on the challenges and opportunities for international public relations practice. Looks at current United States-Arab relations issues in international crisis communication. Discusses those issues, especially the role of culture and media. Proposes strategies including a case study that teachers can use to help students become effective…

  1. METHODOLOGY RELATED TO ESTIMATION OF INVESTMENT APPEAL OF RURAL SETTLEMENTS

    Directory of Open Access Journals (Sweden)

    A. S. Voshev

    2010-03-01

    Full Text Available Conditions for production activity vary considerably from region to region, from area to area, from settlement to settlement. In this connection, investors are challenged to choose an optimum site for a new enterprise. To make the decision, investors follow such references as: investment potential and risk level; their interrelation determines investment appeal of a country, region, area, city or rural settlement. At present Russia faces a problem of «black boxes» represented by a lot of rural settlements. No effective and suitable techniques of quantitative estimation of investment potential, rural settlement risks and systems to make the given information accessible for potential investors exist until now.

  2. New challenges and opportunities in the eddy-covariance methodology for long-term monitoring networks

    Science.gov (United States)

    Papale, Dario; Fratini, Gerardo

    2013-04-01

    Eddy-covariance is the most direct and most commonly applied methodology for measuring exchange fluxes of mass and energy between ecosystems and the atmosphere. In recent years, the number of environmental monitoring stations deploying eddy-covariance systems increased dramatically at the global level, exceeding 500 sites worldwide and covering most climatic and ecological regions. Several long-term environmental research infrastructures such as ICOS, NEON and AmeriFlux selected the eddy-covariance as a method to monitor GHG fluxes and are currently collaboratively working towards defining common measurements standards, data processing approaches, QA/QC procedures and uncertainty estimation strategies, to the aim of increasing defensibility of resulting fluxes and intra and inter-comparability of flux databases. In the meanwhile, the eddy-covariance research community keeps identifying technical and methodological flaws that, in some cases, can introduce - and can have introduced to date - significant biases in measured fluxes or increase their uncertainty. Among those, we identify three issues of presumably greater concern, namely: (1) strong underestimation of water vapour fluxes in closed-path systems, and its dependency on relative humidity; (2) flux biases induced by erroneous measurement of absolute gas concentrations; (3) and systematic errors due to underestimation of vertical wind variance in non-orthogonal anemometers. If not properly addressed, these issues can reduce the quality and reliability of the method, especially as a standard methodology in long-term monitoring networks. In this work, we review the status of the art regarding such problems, and propose new evidences based on field experiments as well as numerical simulations. Our analyses confirm the potential relevance of these issues but also hint at possible coping approaches, to minimize problems during setup design, data collection and post-field flux correction. Corrections are under

  3. Process evaluation of community monitoring under national health mission at Chandigarh, union territory: Methodology and challenges

    Directory of Open Access Journals (Sweden)

    Jaya Prasad Tripathy

    2015-01-01

    Full Text Available Background: Community monitoring was introduced on a pilot mode in 36 selected districts of India in a phased manner. In Chandigarh, it was introduced in the year 2009-2010. A preliminary evaluation of the program was undertaken with special emphasis on the inputs and the processes. Methodology: Quantitative methods included verification against checklists and record reviews. Nonparticipant observation was used to evaluate the conduct of trainings, interviews, and group discussions. Health system had trained health system functionaries (nursing students and Village Health Sanitation Committee [VHSC] members to generate village-based scorecards for assessing community needs. Community needs were assessed independently for two villages under the study area to validate the scores generated by the health system. Results: VHSCs were formed in all 22 villages but without a chairperson or convener. The involvement of VHSC members in the community monitoring process was minimal. The conduct of group discussions was below par due to poor moderation and unequal responses from the group. The community monitoring committees at the state level had limited representation from the non-health sector, lower committees, and the nongovernmental organizations/civil societies. Agreement between the report cards generated by the investigator and the health system in the selected villages was found to be to be fair (0.369 whereas weighted kappa (0.504 was moderate. Conclusion: In spite of all these limitations and challenges, the government has taken a valiant step by trying to involve the community in the monitoring of health services. The dynamic nature of the community warrants incorporation of an evaluation framework into the planning of such programs.

  4. A proposed reductionist solution to address the methodological challenges of inconsistent reflexology maps and poor experimental controls in reflexology research: a discussion paper.

    Science.gov (United States)

    Jones, Jenny; Thomson, Patricia; Lauder, William; Leslie, Stephen J

    2013-03-01

    Reflexology is a complex massage intervention, based on the concept that specific areas of the feet (reflex points) correspond to individual internal organs within the body. Reflexologists trained in the popular Ingham reflexology method claim that massage to these points, using massage techniques unique to reflexology, stimulates an increase in blood supply to the corresponding organ. Reflexology researchers face two key methodological challenges that need to be addressed if a specific treatment-related hemodynamic effect is to be scientifically demonstrated. The first is the problem of inconsistent reflexology foot maps; the second is the issue of poor experimental controls. This article proposes a potential experimental solution that we believe can address both methodological challenges and in doing so, allow any specific hemodynamic treatment effect unique to reflexology to experimentally reveal itself.

  5. Methodological challenges for the evaluation of clinical effectiveness in the context of accelerated regulatory approval: an overview.

    Science.gov (United States)

    Woolacott, Nerys; Corbett, Mark; Jones-Diette, Julie; Hodgson, Robert

    2017-10-01

    Regulatory authorities are approving innovative therapies with limited evidence. Although this level of data is sufficient for the regulator to establish an acceptable risk-benefit balance, it is problematic for downstream health technology assessment, where assessment of cost-effectiveness requires reliable estimates of effectiveness relative to existing clinical practice. Some key issues associated with a limited evidence base include using data, from nonrandomized studies, from small single-arm trials, or from single-center trials; and using surrogate end points. We examined these methodological challenges through a pragmatic review of the available literature. Methods to adjust nonrandomized studies for confounding are imperfect. The relative treatment effect generated from single-arm trials is uncertain and may be optimistic. Single-center trial results may not be generalizable. Surrogate end points, on average, overestimate treatment effects. Current methods for analyzing such data are limited, and effectiveness claims based on these suboptimal forms of evidence are likely to be subject to significant uncertainty. Assessments of cost-effectiveness, based on the modeling of such data, are likely to be subject to considerable uncertainty. This uncertainty must not be underestimated by decision makers: methods for its quantification are required and schemes to protect payers from the cost of uncertainty should be implemented. Crown Copyright © 2017. Published by Elsevier Inc. All rights reserved.

  6. The complexity and challenges of determining GHG (greenhouse gas) emissions from grid electricity consumption and conservation in LCA (life cycle assessment) – A methodological review

    International Nuclear Information System (INIS)

    Soimakallio, Sampo; Kiviluoma, Juha; Saikku, Laura

    2011-01-01

    The way in which GHG (greenhouse gas) emissions associated with grid electricity consumption is handled in different LCA (life cycle assessment) studies, varies significantly. Apart from differences in actual research questions, methodological choices and data set selection have a significant impact on the outcomes. These inconsistencies result in difficulties to compare the findings of various LCA studies. This review paper explores the issue from a methodological point of view. The perspectives of ALCA (attributional life cycle assessment) and CLCA (consequential life cycle assessment) are reflected. Finally, the paper summarizes the key issues and provides suggestions on the way forward. The major challenge related to both of the LCA categories is to determine the GHG emissions of the power production technologies under consideration. Furthermore, the specific challenge in ALCA is to determine the appropriate electricity production mix, and in CLCA, to identify the marginal technologies affected and related consequences. Significant uncertainties are involved, particularly in future-related LCAs, and these should not be ignored. Harmonization of the methods and data sets for various purposes is suggested, acknowledging that selections might be subjective. -- Highlights: ► Methods to assess GHG emissions from grid electricity consumption in LCA vary. ► We explored the major challenges related to various methods. ► Significant uncertainties are involved particularly in future-related GHG emissions. ► The most appropriate method depends on the equity viewpoints.

  7. God, design, and naturalism: Implications of methodological naturalism in science for science-religion relation

    OpenAIRE

    Piotr Bylica; Dariusz Sagan

    2015-01-01

    The aim of this paper is to analyze the implications flowing from adopting methodological naturalism in science, with special emphasis on the relation between science and religion. Methodological naturalism, denying supernatural and teleological explanations, influences the content of scientific theories, and in practice leads to vision of science as compatible with ontological naturalism and in opposition to theism. Ontological naturalism in turn justifies the acceptance of methodological na...

  8. Economic evaluation of health promotion interventions for older people: do applied economic studies meet the methodological challenges?

    Science.gov (United States)

    Huter, Kai; Dubas-Jakóbczyk, Katarzyna; Kocot, Ewa; Kissimova-Skarbek, Katarzyna; Rothgang, Heinz

    2018-01-01

    In the light of demographic developments health promotion interventions for older people are gaining importance. In addition to methodological challenges arising from the economic evaluation of health promotion interventions in general, there are specific methodological problems for the particular target group of older people. There are especially four main methodological challenges that are discussed in the literature. They concern measurement and valuation of informal caregiving, accounting for productivity costs, effects of unrelated cost in added life years and the inclusion of 'beyond-health' benefits. This paper focuses on the question whether and to what extent specific methodological requirements are actually met in applied health economic evaluations. Following a systematic review of pertinent health economic evaluations, the included studies are analysed on the basis of four assessment criteria that are derived from methodological debates on the economic evaluation of health promotion interventions in general and economic evaluations targeting older people in particular. Of the 37 studies included in the systematic review, only very few include cost and outcome categories discussed as being of specific relevance to the assessment of health promotion interventions for older people. The few studies that consider these aspects use very heterogeneous methods, thus there is no common methodological standard. There is a strong need for the development of guidelines to achieve better comparability and to include cost categories and outcomes that are relevant for older people. Disregarding these methodological obstacles could implicitly lead to discrimination against the elderly in terms of health promotion and disease prevention and, hence, an age-based rationing of public health care.

  9. Methodological challenges to multivariate syndromic surveillance: a case study using Swiss animal health data.

    Science.gov (United States)

    Vial, Flavie; Wei, Wei; Held, Leonhard

    2016-12-20

    potential to address more realistic surveillance scenarios through, for example, the inclusion of times series specific parameters, or of covariates known to have an impact on syndrome counts. Nevertheless, many methodological challenges to multivariate surveillance of animal SyS data still remain. Deciding on the amount of corroboration among data streams that is required to escalate into an alert is not a trivial task given the sparse data on the events under consideration (e.g. disease outbreaks).

  10. Qualitative systematic reviews of treatment burden in stroke, heart failure and diabetes - Methodological challenges and solutions

    Science.gov (United States)

    2013-01-01

    Background Treatment burden can be defined as the self-care practices that patients with chronic illness must perform to respond to the requirements of their healthcare providers, as well as the impact that these practices have on patient functioning and well being. Increasing levels of treatment burden may lead to suboptimal adherence and negative outcomes. Systematic review of the qualitative literature is a useful method for exploring the patient experience of care, in this case the experience of treatment burden. There is no consensus on methods for qualitative systematic review. This paper describes the methodology used for qualitative systematic reviews of the treatment burdens identified in three different common chronic conditions, using stroke as our exemplar. Methods Qualitative studies in peer reviewed journals seeking to understand the patient experience of stroke management were sought. Limitations of English language and year of publication 2000 onwards were set. An exhaustive search strategy was employed, consisting of a scoping search, database searches (Scopus, CINAHL, Embase, Medline & PsycINFO) and reference, footnote and citation searching. Papers were screened, data extracted, quality appraised and analysed by two individuals, with a third party for disagreements. Data analysis was carried out using a coding framework underpinned by Normalization Process Theory (NPT). Results A total of 4364 papers were identified, 54 were included in the review. Of these, 51 (94%) were retrieved from our database search. Methodological issues included: creating an appropriate search strategy; investigating a topic not previously conceptualised; sorting through irrelevant data within papers; the quality appraisal of qualitative research; and the use of NPT as a novel method of data analysis, shown to be a useful method for the purposes of this review. Conclusion The creation of our search strategy may be of particular interest to other researchers carrying out

  11. Qualitative systematic reviews of treatment burden in stroke, heart failure and diabetes - methodological challenges and solutions.

    Science.gov (United States)

    Gallacher, Katie; Jani, Bhautesh; Morrison, Deborah; Macdonald, Sara; Blane, David; Erwin, Patricia; May, Carl R; Montori, Victor M; Eton, David T; Smith, Fiona; Batty, G David; Batty, David G; Mair, Frances S

    2013-01-28

    Treatment burden can be defined as the self-care practices that patients with chronic illness must perform to respond to the requirements of their healthcare providers, as well as the impact that these practices have on patient functioning and well being. Increasing levels of treatment burden may lead to suboptimal adherence and negative outcomes. Systematic review of the qualitative literature is a useful method for exploring the patient experience of care, in this case the experience of treatment burden. There is no consensus on methods for qualitative systematic review. This paper describes the methodology used for qualitative systematic reviews of the treatment burdens identified in three different common chronic conditions, using stroke as our exemplar. Qualitative studies in peer reviewed journals seeking to understand the patient experience of stroke management were sought. Limitations of English language and year of publication 2000 onwards were set. An exhaustive search strategy was employed, consisting of a scoping search, database searches (Scopus, CINAHL, Embase, Medline & PsycINFO) and reference, footnote and citation searching. Papers were screened, data extracted, quality appraised and analysed by two individuals, with a third party for disagreements. Data analysis was carried out using a coding framework underpinned by Normalization Process Theory (NPT). A total of 4364 papers were identified, 54 were included in the review. Of these, 51 (94%) were retrieved from our database search. Methodological issues included: creating an appropriate search strategy; investigating a topic not previously conceptualised; sorting through irrelevant data within papers; the quality appraisal of qualitative research; and the use of NPT as a novel method of data analysis, shown to be a useful method for the purposes of this review. The creation of our search strategy may be of particular interest to other researchers carrying out synthesis of qualitative studies

  12. Relating Reasoning Methodologies in Linear Logic and Process Algebra

    Directory of Open Access Journals (Sweden)

    Yuxin Deng

    2012-11-01

    Full Text Available We show that the proof-theoretic notion of logical preorder coincides with the process-theoretic notion of contextual preorder for a CCS-like calculus obtained from the formula-as-process interpretation of a fragment of linear logic. The argument makes use of other standard notions in process algebra, namely a labeled transition system and a coinductively defined simulation relation. This result establishes a connection between an approach to reason about process specifications and a method to reason about logic specifications.

  13. Modeling energy consumption and CO2 emissions at the urban scale: Methodological challenges and insights from the United States

    International Nuclear Information System (INIS)

    Parshall, Lily; Gurney, Kevin; Hammer, Stephen A.; Mendoza, Daniel; Zhou, Yuyu; Geethakumar, Sarath

    2010-01-01

    Local policy makers could benefit from a national, high-resolution inventory of energy consumption and related carbon dioxide (CO 2 ) emissions based on the Vulcan data product, which plots emissions on a 100 km 2 grid. We evaluate the ability of Vulcan to measure energy consumption in urban areas, a scale of analysis required to support goals established as part of local energy, climate or sustainability initiatives. We highlight the methodological challenges of this type of analytical exercise and review alternative approaches. We find that between 37% and 86% of direct fuel consumption in buildings and industry and between 37% and 77% of on-road gasoline and diesel consumption occurs in urban areas, depending on how these areas are defined. We suggest that a county-based definition of urban is preferable to other common definitions since counties are the smallest political unit for which energy data are collected. Urban counties, account for 37% of direct energy consumption, or 50% if mixed urban counties are included. A county-based definition can also improve estimates of per-capita consumption.

  14. Implementation and evaluation of a pharmacist-led hypertension management service in primary care: outcomes and methodological challenges

    OpenAIRE

    Bajorek, Beata; Lemay, Kate S.; Magin, Parker; Roberts, Christopher; Krass, Ines; Armour, Carol L.

    2016-01-01

    Background: Suboptimal utilisation of pharmacotherapy, non-adherence to prescribed treatment, and a lack of monitoring all contribute to poor blood (BP) pressure control in patients with hypertension. Objective: The objective of this study was to evaluate the implementation of a pharmacist-led hypertension management service in terms of processes, outcomes, and methodological challenges. Method: A prospective, controlled study was undertaken within the Australian primary care setting. C...

  15. Modelling marine sediment biogeochemistry: Current knowledge gaps, challenges, and some methodological advice for advancement

    DEFF Research Database (Denmark)

    Lessin, Gennadi; Artioli, Yuri; Almroth-Rosell, Elin

    2018-01-01

    The benthic environment is a crucial component of marine systems in the provision of ecosystem services, sustaining biodiversity and in climate regulation, and therefore important to human society. With the contemporary increase in computational power, model resolution and technological improveme......The benthic environment is a crucial component of marine systems in the provision of ecosystem services, sustaining biodiversity and in climate regulation, and therefore important to human society. With the contemporary increase in computational power, model resolution and technological...... improvements in quality and quantity of benthic data, it is necessary to ensure that benthic systems are appropriately represented in coupled benthic-pelagic biogeochemical and ecological modelling studies. In this paper we focus on five topical challenges related to various aspects of modelling benthic...... environments: organic matter reactivity, dynamics of benthic-pelagic boundary layer, microphytobenthos, biological transport and small-scale heterogeneity, and impacts of episodic events. We discuss current gaps in their understanding and indicate plausible ways ahead. Further, we propose a three...

  16. Defining the methodological challenges and opportunities for an effective science of sociotechnical systems and safety

    Science.gov (United States)

    Waterson, Patrick; Robertson, Michelle M.; Cooke, Nancy J.; Militello, Laura; Roth, Emilie; Stanton, Neville A.

    2015-01-01

    An important part of the application of sociotechnical systems theory (STS) is the development of methods, tools and techniques to assess human factors and ergonomics workplace requirements. We focus in this paper on describing and evaluating current STS methods for workplace safety, as well as outlining a set of six case studies covering the application of these methods to a range of safety contexts. We also describe an evaluation of the methods in terms of ratings of their ability to address a set of theoretical and practical questions (e.g. the degree to which methods capture static/dynamic aspects of tasks and interactions between system levels). The outcomes from the evaluation highlight a set of gaps relating to the coverage and applicability of current methods for STS and safety (e.g. coverage of external influences on system functioning; method usability). The final sections of the paper describe a set of future challenges, as well as some practical suggestions for tackling these. Practitioner Summary: We provide an up-to-date review of STS methods, a set of case studies illustrating their use and an evaluation of their strengths and weaknesses. The paper concludes with a ‘roadmap’ for future work. PMID:25832121

  17. Modelling Marine Sediment Biogeochemistry: Current Knowledge Gaps, Challenges, and Some Methodological Advice for Advancement

    Directory of Open Access Journals (Sweden)

    Gennadi Lessin

    2018-02-01

    Full Text Available The benthic environment is a crucial component of marine systems in the provision of ecosystem services, sustaining biodiversity and in climate regulation, and therefore important to human society. With the contemporary increase in computational power, model resolution and technological improvements in quality and quantity of benthic data, it is necessary to ensure that benthic systems are appropriately represented in coupled benthic-pelagic biogeochemical and ecological modelling studies. In this paper we focus on five topical challenges related to various aspects of modelling benthic environments: organic matter reactivity, dynamics of benthic-pelagic boundary layer, microphytobenthos, biological transport and small-scale heterogeneity, and impacts of episodic events. We discuss current gaps in their understanding and indicate plausible ways ahead. Further, we propose a three-pronged approach for the advancement of benthic and benthic-pelagic modelling, essential for improved understanding, management and prediction of the marine environment. This includes: (A development of a traceable and hierarchical framework for benthic-pelagic models, which will facilitate integration among models, reduce risk of bias, and clarify model limitations; (B extended cross-disciplinary approach to promote effective collaboration between modelling and empirical scientists of various backgrounds and better involvement of stakeholders and end-users; (C a common vocabulary for terminology used in benthic modelling, to promote model development and integration, and also to enhance mutual understanding.

  18. Challenging the reported disadvantages of e-questionnaires and addressing methodological issues of online data collection.

    Science.gov (United States)

    Hunter, Louise

    2012-01-01

    To review the advantages and disadvantages of e-questionnaires, and question whether or not reported disadvantages remain valid or can be limited or circumvented. The internet is likely to become the dominant medium for survey distribution, yet nurses and midwives have been slow to use online technology for research involving questionnaires. Relatively little is known about optimal methods of harnessing the internet's potential in health studies. A small e-questionnaire of health workers. The Medline and Maternity and Infant Care databases were searched for articles containing the words 'web', 'online', or 'internet' and 'survey' or 'questionnaire'. The search was restricted to articles in English published since 2000. The reference lists of retrieved articles were also searched. Reported disadvantages of online data collection, such as sample bias, psychometric distortions, 'technophobia' and lower response rates are discussed and challenged. The author reports her experience of conducting a survey with an e-questionnaire to contribute to the limited body of knowledge in this area, and suggests how to maximise the quantity and quality of responses to e-questionnaires. E-questionnaires offer the researcher an inexpensive, quick and convenient way to collect data. Many of the reported disadvantages of the medium are no longer valid. The science of conducting the perfect e-survey is emerging. However, the lessons learned in the author's study, together with other research, seem to suggest that satisfactory response rates and data quality can be achieved in a relatively short time if certain tactics are used. To get the best results from e-questionnaires, it is suggested that the questionnaire recipients should be targeted carefully and that the value of their potential contribution to the project should be emphasised. E-questionnaires should be convenient, quick and easy to access, and be set out in a way that encourages full and complete responses.

  19. Technologies, Methodologies and Challenges in Network Intrusion Detection and Prevention Systems

    Directory of Open Access Journals (Sweden)

    Nicoleta STANCIU

    2013-01-01

    Full Text Available This paper presents an overview of the technologies and the methodologies used in Network Intrusion Detection and Prevention Systems (NIDPS. Intrusion Detection and Prevention System (IDPS technologies are differentiated by types of events that IDPSs can recognize, by types of devices that IDPSs monitor and by activity. NIDPSs monitor and analyze the streams of network packets in order to detect security incidents. The main methodology used by NIDPSs is protocol analysis. Protocol analysis requires good knowledge of the theory of the main protocols, their definition, how each protocol works.

  20. Characteristic interviews, different strategies: Methodological challenges in qualitative interviewing among respondents with mild intellectual disabilities.

    Science.gov (United States)

    Sigstad, Hanne Marie Høybråten

    2014-06-01

    Conducting qualitative research interviews among individuals with intellectual disabilities, including cognitive limitations and difficulties in communication, presents particular research challenges. One question is whether the difficulties that informants encounter affect interviews to such an extent that the validity of the results is weakened. This article focuses on voluntary informed consent and the specific challenges with the greatest effects on such interviews. The discussion shows that complementary and meaningful descriptions from informants imply the need to employ alternative strategies and methods that may, in other contexts, challenge the traditional understanding of what is acceptable in research. © The Author(s) 2014.

  1. God, design, and naturalism: Implications of methodological naturalism in science for science-religion relation

    Directory of Open Access Journals (Sweden)

    Piotr Bylica

    2015-03-01

    Full Text Available The aim of this paper is to analyze the implications flowing from adopting methodological naturalism in science, with special emphasis on the relation between science and religion. Methodological naturalism, denying supernatural and teleological explanations, influences the content of scientific theories, and in practice leads to vision of science as compatible with ontological naturalism and in opposition to theism. Ontological naturalism in turn justifies the acceptance of methodological naturalism as the best method to know the reality. If we accept realistic interpretation of scientific theories, then methodological naturalism conflicts science with religion. Theistic evolution does not seem to be a proper way to reconcile Darwinism and methodological naturalism with theism. Many of such propositions are boiled down to deism. Although evolution can be interpreted theistically, it is not the way in which majority of modern scientists and respectable scientific institutions understand it.

  2. In vitro cumulative gas production techniques: history, methodological considerations and challenges

    NARCIS (Netherlands)

    Rymer, C.; Huntington, J.A.; Williams, B.A.; Givens, D.I.

    2005-01-01

    Methodology used to measure in vitro gas production is reviewed to determine impacts of sources of variation on resultant gas production profiles (GPP). Current methods include measurement of gas production at constant pressure (e.g., use of gas tight syringes), a system that is inexpensive, but may

  3. Robust Imaging Methodology for Challenging Environments: Wave Equation Dispersion Inversion of Surface Waves

    KAUST Repository

    Li, Jing; Schuster, Gerard T.; Zeng, Zhaofa

    2017-01-01

    A robust imaging technology is reviewed that provide subsurface information in challenging environments: wave-equation dispersion inversion (WD) of surface waves for the shear velocity model. We demonstrate the benefits and liabilities of the method

  4. Practical challenges related to point of care testing

    Directory of Open Access Journals (Sweden)

    Julie L.V. Shaw

    2016-04-01

    Full Text Available Point of care testing (POCT refers to laboratory testing that occurs near to the patient, often at the patient bedside. POCT can be advantageous in situations requiring rapid turnaround time of test results for clinical decision making. There are many challenges associated with POCT, mainly related to quality assurance. POCT is performed by clinical staff rather than laboratory trained individuals which can lead to errors resulting from a lack of understanding of the importance of quality control and quality assurance practices. POCT is usually more expensive than testing performed in the central laboratory and requires a significant amount of support from the laboratory to ensure the quality testing and meet accreditation requirements.Here, specific challenges related to POCT compliance with accreditation standards are discussed along with strategies that can be used to overcome these challenges. These areas include: documentation of POCT orders, charting of POCT results as well as training and certification of individuals performing POCT. Factors to consider when implementing connectivity between POCT instruments and the electronic medical record are also discussed in detail and include: uni-directional versus bidirectional communication, linking patient demographic information with POCT software, the importance of positive patient identification and considering where to chart POCT results in the electronic medical record. Keywords: Point of care Testing, Laboratory accreditation, Medical directive, Results documentation, Electronic Medical Record, Transcription error, Connectivity, Positive patient identification

  5. Practical challenges related to point of care testing.

    Science.gov (United States)

    Shaw, Julie L V

    2016-04-01

    Point of care testing (POCT) refers to laboratory testing that occurs near to the patient, often at the patient bedside. POCT can be advantageous in situations requiring rapid turnaround time of test results for clinical decision making. There are many challenges associated with POCT, mainly related to quality assurance. POCT is performed by clinical staff rather than laboratory trained individuals which can lead to errors resulting from a lack of understanding of the importance of quality control and quality assurance practices. POCT is usually more expensive than testing performed in the central laboratory and requires a significant amount of support from the laboratory to ensure the quality testing and meet accreditation requirements. Here, specific challenges related to POCT compliance with accreditation standards are discussed along with strategies that can be used to overcome these challenges. These areas include: documentation of POCT orders, charting of POCT results as well as training and certification of individuals performing POCT. Factors to consider when implementing connectivity between POCT instruments and the electronic medical record are also discussed in detail and include: uni-directional versus bidirectional communication, linking patient demographic information with POCT software, the importance of positive patient identification and considering where to chart POCT results in the electronic medical record.

  6. Measuring alterations in oscillatory brain networks in schizophrenia with resting-state MEG: State-of-the-art and methodological challenges.

    Science.gov (United States)

    Alamian, Golnoush; Hincapié, Ana-Sofía; Pascarella, Annalisa; Thiery, Thomas; Combrisson, Etienne; Saive, Anne-Lise; Martel, Véronique; Althukov, Dmitrii; Haesebaert, Frédéric; Jerbi, Karim

    2017-09-01

    Neuroimaging studies provide evidence of disturbed resting-state brain networks in Schizophrenia (SZ). However, untangling the neuronal mechanisms that subserve these baseline alterations requires measurement of their electrophysiological underpinnings. This systematic review specifically investigates the contributions of resting-state Magnetoencephalography (MEG) in elucidating abnormal neural organization in SZ patients. A systematic literature review of resting-state MEG studies in SZ was conducted. This literature is discussed in relation to findings from resting-state fMRI and EEG, as well as to task-based MEG research in SZ population. Importantly, methodological limitations are considered and recommendations to overcome current limitations are proposed. Resting-state MEG literature in SZ points towards altered local and long-range oscillatory network dynamics in various frequency bands. Critical methodological challenges with respect to experiment design, and data collection and analysis need to be taken into consideration. Spontaneous MEG data show that local and global neural organization is altered in SZ patients. MEG is a highly promising tool to fill in knowledge gaps about the neurophysiology of SZ. However, to reach its fullest potential, basic methodological challenges need to be overcome. MEG-based resting-state power and connectivity findings could be great assets to clinical and translational research in psychiatry, and SZ in particular. Copyright © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

  7. Development of a Quantitative Methodology to Assess the Impacts of Urban Transport Interventions and Related Noise on Well-Being

    Directory of Open Access Journals (Sweden)

    Matthias Braubach

    2015-05-01

    Full Text Available Well-being impact assessments of urban interventions are a difficult challenge, as there is no agreed methodology and scarce evidence on the relationship between environmental conditions and well-being. The European Union (EU project “Urban Reduction of Greenhouse Gas Emissions in China and Europe” (URGENCHE explored a methodological approach to assess traffic noise-related well-being impacts of transport interventions in three European cities (Basel, Rotterdam and Thessaloniki linking modeled traffic noise reduction effects with survey data indicating noise-well-being associations. Local noise models showed a reduction of high traffic noise levels in all cities as a result of different urban interventions. Survey data indicated that perception of high noise levels was associated with lower probability of well-being. Connecting the local noise exposure profiles with the noise-well-being associations suggests that the urban transport interventions may have a marginal but positive effect on population well-being. This paper also provides insight into the methodological challenges of well-being assessments and highlights the range of limitations arising from the current lack of reliable evidence on environmental conditions and well-being. Due to these limitations, the results should be interpreted with caution.

  8. Development of a quantitative methodology to assess the impacts of urban transport interventions and related noise on well-being.

    Science.gov (United States)

    Braubach, Matthias; Tobollik, Myriam; Mudu, Pierpaolo; Hiscock, Rosemary; Chapizanis, Dimitris; Sarigiannis, Denis A; Keuken, Menno; Perez, Laura; Martuzzi, Marco

    2015-05-26

    Well-being impact assessments of urban interventions are a difficult challenge, as there is no agreed methodology and scarce evidence on the relationship between environmental conditions and well-being. The European Union (EU) project "Urban Reduction of Greenhouse Gas Emissions in China and Europe" (URGENCHE) explored a methodological approach to assess traffic noise-related well-being impacts of transport interventions in three European cities (Basel, Rotterdam and Thessaloniki) linking modeled traffic noise reduction effects with survey data indicating noise-well-being associations. Local noise models showed a reduction of high traffic noise levels in all cities as a result of different urban interventions. Survey data indicated that perception of high noise levels was associated with lower probability of well-being. Connecting the local noise exposure profiles with the noise-well-being associations suggests that the urban transport interventions may have a marginal but positive effect on population well-being. This paper also provides insight into the methodological challenges of well-being assessments and highlights the range of limitations arising from the current lack of reliable evidence on environmental conditions and well-being. Due to these limitations, the results should be interpreted with caution.

  9. Peritoneal dialysis-related peritonitis: challenges and solutions

    Science.gov (United States)

    Salzer, William L

    2018-01-01

    Peritoneal dialysis is an effective treatment modality for patients with end-stage renal disease. The relative use of peritoneal dialysis versus hemodialysis varies widely by country. Data from a 2004 survey reports the percentage of patients with end-stage renal disease treated with peritoneal dialysis to be 5%–10% in economically developed regions like the US and Western Europe to as much as 75% in Mexico. This disparity is probably related to the availability and access to hemodialysis, or in some cases patient preference for peritoneal over hemodialysis. Peritoneal dialysis-related peritonitis remains the major complication and primary challenge to the long-term success of peritoneal dialysis. Fifty years ago, with the advent of the Tenckhoff catheter, patients averaged six episodes of peritonitis per year on peritoneal dialysis. In 2016, the International Society for Peritoneal Dialysis proposed a benchmark of 0.5 episodes of peritonitis per year or one episode every 2 years. Despite the marked reduction in peritonitis over time, peritonitis for the individual patient is problematic. The mortality for an episode of peritonitis is 5% and is a cofactor for mortality in another 16% of affected patients. Prevention of peritonitis and prompt and appropriate management of peritonitis is essential for the long-term success of peritoneal dialysis in all patients. In this review, challenges and solutions are addressed regarding the pathogenesis, clinical features, diagnosis, treatment, and prevention of peritoneal dialysis-related peritonitis from the viewpoint of an infectious disease physician.

  10. Methodological Challenges to Economic Evaluations of Vaccines: Is a Common Approach Still Possible?

    Science.gov (United States)

    Jit, Mark; Hutubessy, Raymond

    2016-06-01

    Economic evaluation of vaccination is a key tool to inform effective spending on vaccines. However, many evaluations have been criticised for failing to capture features of vaccines which are relevant to decision makers. These include broader societal benefits (such as improved educational achievement, economic growth and political stability), reduced health disparities, medical innovation, reduced hospital beds pressures, greater peace of mind and synergies in economic benefits with non-vaccine interventions. Also, the fiscal implications of vaccination programmes are not always made explicit. Alternative methodological frameworks have been proposed to better capture these benefits. However, any broadening of the methodology for economic evaluation must also involve evaluations of non-vaccine interventions, and hence may not always benefit vaccines given a fixed health-care budget. The scope of an economic evaluation must consider the budget from which vaccines are funded, and the decision-maker's stated aims for that spending to achieve.

  11. SUSTAINABILITY ASSESSMENT IN URBAN PLANNING. A CHALLENGE FOR A METHODOLOGICAL CONSTRUCTION: MONTREAL AS CASE STUDY

    Directory of Open Access Journals (Sweden)

    María de Lourdes Flores Lucero

    2014-09-01

    Full Text Available In this paper we describe the methodological process for the qualitative evaluation of the concept of sustainability and its application in the island of Montreal. At the same time we present our theoretical approach and the main results issued of the assessment. We take as analytical tools the Montreal Urban Plan of 2004 and the Strategic Plan for Sustainable Development 2005. We conclude with two main points, first, that the theoretical and pragmatic aspects of urban sustainability in Montreal have been treated in an organic, complex, dynamic and flexible way, allowing social participation and the inclusion of the values of all stakeholders, which are both key elements to follow the path towards sustainability; and secondly, that the approach to an object with such features requires the construction of complex, organic and methodological processes.

  12. Methodological Challenges of Identifying Ultimate Land Use Changes Caused by Biofuel Production

    DEFF Research Database (Denmark)

    Wenzel, Henrik; Kløverpris, Jesper; Nielsen, Per Henning

    2007-01-01

    that is only poorly dealt with by LCA methods. Even though the use of land, or change of land cover and its eco-systems, is acknowledged to be a very important impact of human activities, a methodology for assessing this impact category has not yet  been properly developed within LCA. Some LCA scientists have...... looked into methods for assessing the impacts of given changes of land use, i.e. the impact assessment component of the LCA, but very few have looked into how to actually do the inventory modelling, i.e. how to identify which land is ultimately affected by the decision and system under study. State...... in the systems being studied. The aims of this paper is to analyse the mechanisms influencing the long-term land use consequences of changes in crop demand and propose a methodological framework for identifying these consequences within a global scope. The outset of the paper is the principles of consequential...

  13. METHODOLOGICAL APPROACHES AND CHALLENGES IN ASSESSING THE VALUE OF INTELLECTUAL CAPITAL

    Directory of Open Access Journals (Sweden)

    E. D. Katulskij

    2016-01-01

    Full Text Available Presence at the enterprise znanievyh resources determines its capacity for sustainable and competitive development. The set of knowledge, skills and abilities (which has operational and management personnel, including transformed in intangible and other assets are considered to be the intellectual capital of the enterprise. Empirically, the presence of the intellectual capital of the enterprise can be identified by its success in the market and the ability to generate a high value added product. However, scientific and methodological point of view, approaches to assessing intellectual capital are currently not standardized and do not provide an objective valuation of the capital.This paper presents an overview of the methodological approaches to the valuation of the intellectual capital of companies and shows the problems of using these approaches in analytical procedures. Based on the materials conclusion about the necessity of further development of the intellectual capital evaluation methods enterprises it was made.The purpose / goal. The purpose of this article is to study the specifics of basic methodological approaches to the valuation of the intellectual capital of enterprises. Moreover, among the main tasks is to provide: an analysis of the most frequently used techniques in the Russian and international practice, assessment of intellectual capital.Methodology. The article is a content analysis of the theoretical and scientific-methodical positions, describing the key and the most frequently used Russian and international approaches to the evaluation of the intellectual capital of enterprises.Conclusions / relevance. The practical significance of this paper is to identify the main issues that arise in the evaluation of the intellectual capital of the enterprises, which determines the need for further scientific development and complement the currently used evaluation methods.

  14. Engaging Australian Aboriginal narratives to challenge attitudes and create empathy in health care: a methodological perspective.

    Science.gov (United States)

    Wain, Toni; Sim, Moira; Bessarab, Dawn; Mak, Donna; Hayward, Colleen; Rudd, Cobie

    2016-06-02

    Unconscious bias and negative attitudes towards minority groups have detrimental effects on the way health care is, or is not, provided to these groups. Recognition of racist attitudes and behaviours as well as understanding clients' experiences of health and health care are pivotal to developing better health care strategies to positively impact on the quality and safety of care provided to Indigenous people. Indigenous research demands inclusive research processes and the use of culturally appropriate methodologies. This paper presents a methodological account of collecting narratives which accurately and respectfully reflect Aboriginal Australians' experiences with health care in Western Australia. The purpose of these narratives is to provide health students and professionals with an opportunity to 'walk-in the shoes' of Aboriginal people where face-to-face interaction is not feasible. With the incorporation of Indigenous peoples' voices being an important link in cultural safety, the project was led by an Indigenous Reference group, who encouraged active participation of Aboriginal people in all areas of the project. Using a phenomenological approach and guided by the Indigenous Reference group, yarning data collection was implemented to collect stories focusing on Aboriginal people's experiences with health care services. An open-access, on-line website was established to host education resources developed from these "yarns". Yarning provided a rich source of information on personal experiences and encouraged the story provider to recognise their facilitative role in the research process. While the methodology used in this project was lengthy and labour-intensive it afforded a respectful manner for story collection and highlighted several innate flaws when Western methods are applied to an Indigenous context. Engagement of an Indigenous Reference Group was pivotal to designing an appropriate methodology that incorporated the voices of Aboriginal people in a

  15. Assessing climate risks across different business sectors and industries: an investigation of methodological challenges at national scale for the UK

    Science.gov (United States)

    Surminski, Swenja; Di Mauro, Manuela; Baglee, J. Alastair R.; Connell, Richenda K.; Hankinson, Joel; Haworth, Anna R.; Ingirige, Bingunath; Proverbs, David

    2018-06-01

    Climate change poses severe risks for businesses, which companies as well as governments need to understand in order to take appropriate steps to manage those. This, however, represents a significant challenge as climate change risk assessment is itself a complex, dynamic and geographically diverse process. A wide range of factors including the nature of production processes and value chains, the location of business sites as well as relationships and interdependencies with customers and suppliers play a role in determining if and how companies are impacted by climate risks. This research explores the methodological challenges for a national-scale assessment of climate risks through the lens of the UK Climate Change Risk Assessment (UKCCRA) process and compares the approaches adopted in the first and second UKCCRA (2011, 2016), while also reflecting on international experiences elsewhere. A review of these issues is presented, drawing on a wide body of contemporary evidence from a range of sources including the research disciplines, grey literature and government policy. The study reveals the methodological challenges and highlights six broad themes, namely scale, evidence base, adaptation responses, scope, interdependencies and public policy. The paper concludes by identifying suitable lessons for future national climate risk assessments, which should guide the next phase of research in preparation for UKCCRA3 and those of national-level risk assessments elsewhere. This article is part of the theme issue `Advances in risk assessment for climate change adaptation policy'.

  16. Characteristic Interviews, Different Strategies: Methodological Challenges in Qualitative Interviewing among Respondents with Mild Intellectual Disabilities

    Science.gov (United States)

    Sigstad, Hanne Marie Høybråten

    2014-01-01

    Conducting qualitative research interviews among individuals with intellectual disabilities, including cognitive limitations and difficulties in communication, presents particular research challenges. One question is whether the difficulties that informants encounter affect interviews to such an extent that the validity of the results is weakened.…

  17. Benefits and challenges of qualitative methodologies in cross-cultural psychology studies

    NARCIS (Netherlands)

    de Quadros Rigoni, R.

    2016-01-01

    Qualitative research has been considered increasingly valuable for cross-cultural psychology studies, but its contributions and challenges to the field remain under discussed. This chapter does that by analysing a qualitative study which compares interpretive beliefs and behaviour of street-level

  18. Integrating Ethics into International Business Teaching: Challenges and Methodologies in the Greater China Context

    Science.gov (United States)

    Whitla, Paul

    2011-01-01

    This paper examines the process of integrating ethics into the teaching of international business within the Greater China region. An example of how ethics is integrated into a required undergraduate international business course at a Hong Kong based university is presented. The contextual challenges of developing a course for use in the Greater…

  19. Measurement and verification of low income energy efficiency programs in Brazil: Methodological challenges

    Energy Technology Data Exchange (ETDEWEB)

    Martino Jannuzzi, Gilberto De; Rodrigues da Silva, Ana Lucia; Melo, Conrado Augustus de; Paccola, Jose Angelo; Dourado Maia Gomes, Rodolfo (State Univ. of Campinas, International Energy Initiative (Brazil))

    2009-07-01

    Electric utilities in Brazil are investing about 80 million dollars annually in low-income energy efficiency programs, about half of their total compulsory investments in end-use efficiency programs under current regulation. Since 2007 the regulator has enforced the need to provide evaluation plans for the programs delivered. This paper presents the measurement and verification (MandV) methodology that has been developed to accommodate the characteristics of lighting and refrigerator programs that have been introduced in the Brazilian urban and peri-urban slums. A combination of household surveys, end-use measurements and metering at the transformers and grid levels were performed before and after the program implementation. The methodology has to accommodate the dynamics, housing, electrical wiring and connections of the population as well as their ability to pay for the electricity and program participation. Results obtained in slums in Rio de Janeiro are presented. Impacts of the programs were evaluated in energy terms to households and utilities. Feedback from the evaluations performed also permitted the improvement in the design of new programs for low-income households.

  20. Challenges of characterization of radioactive waste with High composition variability and their consequences measurement methodology

    International Nuclear Information System (INIS)

    Lexa, D.

    2014-01-01

    Radioactive waste characterization is a key step in every nuclear decommissioning project. It normally relies on a combination of facility operational history with results of destructive and non-destructive analysis. A particularly challenging situation arises when historical waste from a nuclear research facility is to be characterized, meaning little or no radiological information is available and the composition of the waste is highly variable. The nuclide vector concept is of limited utility, resulting in increased requirements placed on both the extent and performance of destructive and non-destructive analysis. Specific challenges are illustrated on an example of the decommissioning project underway at the Joint Research Center of the European Commission in Ispra. (author)

  1. Gotta survey somebody : Methodological challenges in population studies of older people

    OpenAIRE

    Kelfve, Susanne

    2015-01-01

    Conducting representative surveys of older people is challenging. This thesis aims to analyze a) the characteristics of individuals at risk of being underrepresented in surveys of older people, b) the systematic errors likely to occur as a result of these selections, and c) whether these systematic errors can be minimized by weighting adjustments.   In Study I, we investigated a) who would be missing from a survey that excluded those living in institutions and that did not use indirect interv...

  2. Conceptual and methodological challenges for neuroimaging studies of autistic spectrum disorders

    OpenAIRE

    Mazzone, Luigi; Curatolo, Paolo

    2010-01-01

    Abstract Autistic Spectrum Disorders (ASDs) are a set of complex developmental disabilities defined by impairment in social interaction and communication, as well as by restricted interests or repetitive behaviors. Neuroimaging studies have substantially advanced our understanding of the neural mechanisms that underlie the core symptoms of ASDs. Nevertheless, a number of challenges still remain in the application of neuroimaging techniques to the study of ASDs. We review three major conceptua...

  3. Transnationality or Globality? The Korean Wave and Methodological Challenges in Media and Cultural studies

    OpenAIRE

    Kang, Jaeho

    2017-01-01

    Making the case for a new media/cultural studies that takes a transregional, transcultural and transdisciplinary approach, this contribution notes how the global popularity of Korean Wave has highlighted the limitations of methods rooted in notions of national identities. Studies have challenged western hegemony of knowledge production and are suggestive of new academic communities beyond Eurocentric nation states that may be both multinational and multicultural.This contribution however warn...

  4. Solving a methodological challenge in work stress evaluation with the Stress Assessment and Research Toolkit (StART): a study protocol.

    Science.gov (United States)

    Guglielmi, Dina; Simbula, Silvia; Vignoli, Michela; Bruni, Ilaria; Depolo, Marco; Bonfiglioli, Roberta; Tabanelli, Maria Carla; Violante, Francesco Saverio

    2013-06-22

    Stress evaluation is a field of strong interest and challenging due to several methodological aspects in the evaluation process. The aim of this study is to propose a study protocol to test a new method (i.e., the Stress Assessment and Research Toolkit) to assess psychosocial risk factors at work. This method addresses several methodological issues (e.g., subjective vs. objective, qualitative vs quantitative data) by assessing work-related stressors using different kinds of data: i) organisational archival data (organisational indicators sheet); ii) qualitative data (focus group); iii) worker perception (questionnaire); and iv) observational data (observational checklist) using mixed methods research. In addition, it allows positive and negative aspects of work to be considered conjointly, using an approach that considers at the same time job demands and job resources. The integration of these sources of data can reduce the theoretical and methodological bias related to stress research in the work setting, allows researchers and professionals to obtain a reliable description of workers' stress, providing a more articulate vision of psychosocial risks, and allows a large amount of data to be collected. Finally, the implementation of the method ensures in the long term a primary prevention for psychosocial risk management in that it aims to reduce or modify the intensity, frequency or duration of organisational demands.

  5. Challenges in developing a methodology for reviewing Nordic research on media and technology in MTE

    DEFF Research Database (Denmark)

    Elf, Nikolaj Frydensbjerg; Hanghøj, Thorkild

    2013-01-01

    important as there exist several alternatives to ‘technology’ and ‘media’ – e.g. ‘the expanded text’, ‘digital media’, ‘multimodal media’ etc. Thus, M&T within MTE can be seen as didactic border objects. Analyzing the Danish studies, we find a clear predominance of interventionist approaches that try...... to push forward the use of new, typically digital M&T. Overall, the studies suggest that such interventions are interpreted in both integrating and disintegrating ways by participating teachers and students. Discussion No systematic reviews of research on M&T in MTE have been made transnationally......The paper presents a methodological framework for a research project, which aims at reviewing Nordic research of mother tongue education with a particular focus on media and technology (M&T). Relevant national context During the last decade, several research projects have had an explicit focus...

  6. Inernational research in health care management: its need in the 21st century, methodological challenges, ethical issues, pitfalls, and practicalities.

    Science.gov (United States)

    Buttigieg, Sandra C; Rathert, Cheryl; D'Aunno, Thomas A; Savage, Grant T

    2015-01-01

    This commentary argues in favor of international research in the 21st century. Advances in technology, science, communication, transport, and infrastructure have transformed the world into a global village. Industries have increasingly adopted globalization strategies. Likewise, the health sector is more internationalized whereby comparisons between diverse health systems, international best practices, international benchmarking, cross-border health care, and cross-cultural issues have become important subjects in the health care literature. The focus has now turned to international, collaborative, cross-national, and cross-cultural research, which is by far more demanding than domestic studies. In this commentary, we explore the methodological challenges, ethical issues, pitfalls, and practicalities within international research and offer possible solutions to address them. The commentary synthesizes contributions from four scholars in the field of health care management, who came together during the annual meeting of the Academy of Management to discuss with members of the Health Care Management Division the challenges of international research. International research is worth pursuing; however, it calls for scholarly attention to key methodological and ethical issues for its success. This commentary addresses salient issues pertaining to international research in one comprehensive account.

  7. The Mediterranean diet and age-related cognitive functioning: A systematic review of study findings and neuropsychological assessment methodology.

    Science.gov (United States)

    Knight, Alissa; Bryan, Janet; Murphy, Karen

    2017-10-01

    The primary aims of this review were to identify studies investigating the association between the MedDiet pattern and age-related cognitive function, to determine the current status of knowledge, and to ascertain whether a lack of standardization with the operationalization of age-related cognitive function and differences in the chosen neuropsychological assessment methodology impacted on the results and findings. The systematic review protocol for this paper was carried out following the statement and general principles of PRISMA and the UK Centre for Reviews and Dissemination (CRD). A systematic search of electronic databases yielded two cross-sectional studies, two cross-sectional/prospective studies, and 11 prospective studies for inclusion. Among this group of studies, conflicting results and conclusions regarding the efficacy of the MedDiet as a therapeutic approach for age-related cognitive function were found. Of importance, clear differences among studies in relation to neuropsychological assessment methodology were identified. Such disparity appeared to be one plausible factor contributing to the lack of consensus among study findings. One of the important challenges for future research will be to aim toward some kind of standardized neuropsychological assessment criteria. This type of endeavor will enable the ability to validate with greater confidence, whether or not adherence to a MedDiet does promote benefit for age-related cognitive function.

  8. Implementation and evaluation of a pharmacist-led hypertension management service in primary care: outcomes and methodological challenges.

    Science.gov (United States)

    Bajorek, Beata; Lemay, Kate S; Magin, Parker; Roberts, Christopher; Krass, Ines; Armour, Carol L

    2016-01-01

    Suboptimal utilisation of pharmacotherapy, non-adherence to prescribed treatment, and a lack of monitoring all contribute to poor blood (BP) pressure control in patients with hypertension. The objective of this study was to evaluate the implementation of a pharmacist-led hypertension management service in terms of processes, outcomes, and methodological challenges. A prospective, controlled study was undertaken within the Australian primary care setting. Community pharmacists were recruited to one of three study groups: Group A (Control - usual care), Group B (Intervention), or Group C (Short Intervention). Pharmacists in Groups B and C delivered a service comprising screening and monitoring of BP, as well as addressing poor BP control through therapeutic adjustment and adherence strategies. Pharmacists in Group C delivered the shortened version of the service. Significant changes to key outcome measures were observed in Group C: reduction in systolic and diastolic BPs at the 3-month visit (P<0.01 and P<0.01, respectively), improvement in medication adherence scores (P=0.01), and a slight improvement in quality of life (EQ-5D-3L Index) scores (P=0.91). There were no significant changes in Group B (the full intervention), and no differences in comparison to Group A (usual care). Pharmacists fed-back that patient recruitment was a key barrier to service implementation, highlighting the methodological implications of screening. A collaborative, pharmacist-led hypertension management service can help monitor BP, improve medication adherence, and optimise therapy in a step-wise approach. However, blood pressure screening can effect behaviour change in patients, presenting methodological challenges in the evaluation of services in this context.

  9. Implementation and evaluation of a pharmacist-led hypertension management service in primary care: outcomes and methodological challenges

    Directory of Open Access Journals (Sweden)

    Bajorek B

    2016-06-01

    Full Text Available Background: Suboptimal utilisation of pharmacotherapy, non-adherence to prescribed treatment, and a lack of monitoring all contribute to poor blood (BP pressure control in patients with hypertension. Objective: The objective of this study was to evaluate the implementation of a pharmacist-led hypertension management service in terms of processes, outcomes, and methodological challenges. Method: A prospective, controlled study was undertaken within the Australian primary care setting. Community pharmacists were recruited to one of three study groups: Group A (Control – usual care, Group B (Intervention, or Group C (Short Intervention. Pharmacists in Groups B and C delivered a service comprising screening and monitoring of BP, as well as addressing poor BP control through therapeutic adjustment and adherence strategies. Pharmacists in Group C delivered the shortened version of the service. Results: Significant changes to key outcome measures were observed in Group C: reduction in systolic and diastolic BPs at the 3-month visit (P<0.01 and P<0.01, respectively, improvement in medication adherence scores (P=0.01, and a slight improvement in quality of life (EQ-5D-3L Index scores (P=0.91. There were no significant changes in Group B (the full intervention, and no differences in comparison to Group A (usual care. Pharmacists fed-back that patient recruitment was a key barrier to service implementation, highlighting the methodological implications of screening. Conclusion: A collaborative, pharmacist-led hypertension management service can help monitor BP, improve medication adherence, and optimise therapy in a step-wise approach. However, blood pressure screening can effect behaviour change in patients, presenting methodological challenges in the evaluation of services in this context.

  10. Methodological challenges and analytic opportunities for modeling and interpreting Big Healthcare Data.

    Science.gov (United States)

    Dinov, Ivo D

    2016-01-01

    Managing, processing and understanding big healthcare data is challenging, costly and demanding. Without a robust fundamental theory for representation, analysis and inference, a roadmap for uniform handling and analyzing of such complex data remains elusive. In this article, we outline various big data challenges, opportunities, modeling methods and software techniques for blending complex healthcare data, advanced analytic tools, and distributed scientific computing. Using imaging, genetic and healthcare data we provide examples of processing heterogeneous datasets using distributed cloud services, automated and semi-automated classification techniques, and open-science protocols. Despite substantial advances, new innovative technologies need to be developed that enhance, scale and optimize the management and processing of large, complex and heterogeneous data. Stakeholder investments in data acquisition, research and development, computational infrastructure and education will be critical to realize the huge potential of big data, to reap the expected information benefits and to build lasting knowledge assets. Multi-faceted proprietary, open-source, and community developments will be essential to enable broad, reliable, sustainable and efficient data-driven discovery and analytics. Big data will affect every sector of the economy and their hallmark will be 'team science'.

  11. Ethical challenges embedded in qualitative research interviews with close relatives.

    Science.gov (United States)

    Haahr, Anita; Norlyk, Annelise; Hall, Elisabeth Oc

    2014-02-01

    Nurse researchers engaged in qualitative interviews with patients and spouses in healthcare may often experience being in unforeseen ethical dilemmas. Researchers are guided by the bioethical principles of justice, beneficence, non-maleficence, respect for human rights and respect for autonomy through the entire research process. However, these principles are not sufficient to prepare researchers for unanticipated ethical dilemmas related to qualitative research interviews. We describe and discuss ethically challenging and difficult moments embedded in two cases from our own phenomenological interview studies. We argue that qualitative interviews involve navigation between being guided by bioethics as a researcher, being a therapist/nurse and being a fellow human being or even a friend. The researchers' premises to react to unexpected situations and act in a sound ethical manner must be enhanced, and there is a need for an increased focus on the researchers' ethical preparation and to continually address and discuss cases from their own interviews.

  12. Ethical Challenges embedded in qualitative research interviews with close relatives

    DEFF Research Database (Denmark)

    Haahr, Anita; Norlyk, Annelise; Hall, Elisabeth

    2013-01-01

    Nurse researchers engaged in qualitative interviews with patients and spouses in healthcare may often experience being in unforseen ethical dilemmas. Researchers are guided by the bioethical principles of justice, beneficence, non-maleficence respect for human rights and respect for autonomy...... through the entire research process. However, these principles are not sufficient to prepare researchers for unanticipated ethical dilemmas related to qualitative researchs interviews. We describe and discuss ethically challenging and difficult moments embedded in two cases from our own phenomenological...... interview studies. We argue that qualitative interviews involve navigation between being guided by bioethics as a researcher, being a therapist/nurse and being a fellow human being or even a friend. The researchers' premises to react to unexpected situations and act in a sound ethical manner must...

  13. After the crisis? Big Data and the methodological challenges of empirical sociology

    Directory of Open Access Journals (Sweden)

    Roger Burrows

    2014-07-01

    Full Text Available Google Trends reveals that at the time we were writing our article on ‘The Coming Crisis of Empirical Sociology’ in 2007 almost nobody was searching the internet for ‘Big Data’. It was only towards the very end of 2010 that the term began to register, just ahead of an explosion of interest from 2011 onwards. In this commentary we take the opportunity to reflect back on the claims we made in that original paper in light of more recent discussions about the social scientific implications of the inundation of digital data. Did our paper, with its emphasis on the emergence of, what we termed, ‘social transactional data’ and ‘digital byproduct data’ prefigure contemporary debates that now form the basis and rationale for this excellent new journal? Or was the paper more concerned with broader methodological, theoretical and political debates that have somehow been lost in all of the loud babble that has come to surround Big Data. Using recent work on the BBC Great British Class Survey as an example this brief paper offers a reflexive and critical reflection on what has become – much to the surprise of its authors – one of the most cited papers in the discipline of sociology in the last decade.

  14. PASSCAL Instrument Center Support for Cryoseismology: Methodologies, Challenges, Development and Instrumentation

    Science.gov (United States)

    Beaudoin, B. C.; Anderson, K. R.; Bilek, S. L.; Carpenter, P.; Childs, D.; Chung, P.; Huerta, A. D.; Lingutla, N.; Nikolaus, K.; Winberry, J. P.

    2017-12-01

    Remote portable seismic stations are, in most cases, constrained by logistics and cost. High latitude operations introduce environmental, technical and logistical challenges that require substantially more engineering work to ensure robust, high quality data return. Since 2006, IRIS PASSCAL has been funded by NSF to develop, deploy, and maintain a pool of polar specific seismic stations. At roughly the same time, PASSCAL began supporting experiments specifically targeting glacier dynamics such as the mechanisms of subglacial hydrology, basal shear stress, ice stream stick slip mechanisms, and glacier seismicity. Although much of the development for high-latitude deployments was directly applicable to cryoseismology, these new experiments introduced a unique series of challenges including high ablation, standing water, and moving stations. Our polar development objectives have focused on: Reducing station power requirements, size and weight; Extending the operational temperature of a station; Simplifying logistics; Engineering solutions that are cost effective, manufacturable, serviceable and reusable; And, developing high-latitude communications for both state-of-health and data transmission. To these ends, PASSCAL continues testing new power storage technology, refining established power systems for lighter and smaller power banks, and exploring telemetry solutions to increase high-bandwidth communication options and abilities for remote seismic stations. Further enhancing PASSCAL's ability to support cryoseismology is a recent NSF funded collaborative effort lead by Central Washing University joined by IRIS and New Mexico Tech to build a Geophysical Earth Observatory for Ice Covered Environments (GEOICE). The GEOICE instrument, power system and other integrated ancillary components are designed to require minimal installation time and logistical load (i.e., size and weight), while maximizing ease-of-use in the field and optimizing costs of instrumentation and

  15. Incorporating intersectionality theory into population health research methodology: challenges and the potential to advance health equity.

    Science.gov (United States)

    Bauer, Greta R

    2014-06-01

    Intersectionality theory, developed to address the non-additivity of effects of sex/gender and race/ethnicity but extendable to other domains, allows for the potential to study health and disease at different intersections of identity, social position, processes of oppression or privilege, and policies or institutional practices. Intersectionality has the potential to enrich population health research through improved validity and greater attention to both heterogeneity of effects and causal processes producing health inequalities. Moreover, intersectional population health research may serve to both test and generate new theories. Nevertheless, its implementation within health research to date has been primarily through qualitative research. In this paper, challenges to incorporation of intersectionality into population health research are identified or expanded upon. These include: 1) confusion of quantitative terms used metaphorically in theoretical work with similar-sounding statistical methods; 2) the question of whether all intersectional positions are of equal value, or even of sufficient value for study; 3) distinguishing between intersecting identities, social positions, processes, and policies or other structural factors; 4) reflecting embodiment in how processes of oppression and privilege are measured and analysed; 5) understanding and utilizing appropriate scale for interactions in regression models; 6) structuring interaction or risk modification to best convey effects, and; 7) avoiding assumptions of equidistance or single level in the design of analyses. Addressing these challenges throughout the processes of conceptualizing and planning research and in conducting analyses has the potential to improve researchers' ability to more specifically document inequalities at varying intersectional positions, and to study the potential individual- and group-level causes that may drive these observed inequalities. A greater and more thoughtful incorporation

  16. School Psychology as a Relational Enterprise: The Role and Process of Qualitative Methodology

    Science.gov (United States)

    Newman, Daniel S.; Clare, Mary M.

    2016-01-01

    The purpose of this article is to explore the application of qualitative research to establishing a more complete understanding of relational processes inherent in school psychology practice. We identify the building blocks of rigorous qualitative research design through a conceptual overview of qualitative paradigms, methodologies, methods (i.e.,…

  17. Methodological challenges in designing dementia prevention trials - The European Dementia Prevention Initiative (EDPI)

    NARCIS (Netherlands)

    Richard, Edo; Andrieu, Sandrine; Solomon, Alina; Mangialasche, Francesca; Ahtiluoto, Satu; Moll van Charante, Eric P.; Coley, Nicola; Fratiglioni, Laura; Neely, Anna Stigsdotter; Vellas, Bruno; van Gool, Willem A.; Kivipelto, Miia

    2012-01-01

    Recent epidemiological studies have indicated numerous associations between vascular and lifestyle related risk factors and incident dementia. However, evidence from randomised controlled trials (RCT) showing effectiveness of interventions aimed at these risk factors in preventing or postponing

  18. Methodological challenges in indirect treatment comparisons: spotlight on a recent comparison of long-acting injectable aripiprazole versus paliperidone palmitate in the treatment of schizophrenia.

    Science.gov (United States)

    Singh, Arun; Gopal, Srihari; Kim, Edward; Mathews, Maju; Kern-Sliwa, Jennifer; Turkoz, Ibrahim; Wooller, Annette; Berlin, Jesse

    2018-03-01

    In a recent study, an indirect treatment comparison was performed to examine the relative efficacy and tolerability of aripiprazole once monthly and paliperidone palmitate once monthly. The authors concluded that the results may suggest relative advantages for aripiprazole once monthly over paliperidone palmitate once monthly in the short-term treatment of schizophrenia. However, the validity of the study is compromised as an indirect treatment comparison using extant data may violate important assumptions. Other methodological issues identified further highlight the challenges of performing indirect treatment comparisons.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/.

  19. Robust Imaging Methodology for Challenging Environments: Wave Equation Dispersion Inversion of Surface Waves

    KAUST Repository

    Li, Jing

    2017-12-22

    A robust imaging technology is reviewed that provide subsurface information in challenging environments: wave-equation dispersion inversion (WD) of surface waves for the shear velocity model. We demonstrate the benefits and liabilities of the method with synthetic seismograms and field data. The benefits of WD are that 1) there is no layered medium assumption, as there is in conventional inversion of dispersion curves, so that the 2D or 3D S-velocity model can be reliably obtained with seismic surveys over rugged topography, and 2) WD mostly avoids getting stuck in local minima. The synthetic and field data examples demonstrate that WD can accurately reconstruct the S-wave velocity distributions in laterally heterogeneous media if the dispersion curves can be identified and picked. The WD method is easily extended to anisotropic media and the inversion of dispersion curves associated with Love wave. The liability is that is almost as expensive as FWI and only recovers the Vs distribution to a depth no deeper than about 1/2~1/3 wavelength.

  20. Methodological challenges surrounding direct-to-consumer advertising research--the measurement conundrum.

    Science.gov (United States)

    Hansen, Richard A; Droege, Marcus

    2005-06-01

    Numerous studies have focused on the impact of direct-to-consumer (DTC) prescription drug advertising on consumer behavior and health outcomes. These studies have used various approaches to assess exposure to prescription drug advertising and to measure the subsequent effects of such advertisements. The objectives of this article are to (1) discuss measurement challenges involved in DTC advertising research, (2) summarize measurement approaches commonly identified in the literature, and (3) discuss contamination, time to action, and endogeneity as specific problems in measurement design and application. We conducted a review of the professional literature to identify illustrative approaches to advertising measurement. Specifically, our review of the literature focused on measurement of DTC advertising exposure and effect. We used the hierarchy-of-effects model to guide our discussion of processing and communication effects. Other effects were characterized as target audience action, sales, market share, and profit. Overall, existing studies have used a variety of approaches to measure advertising exposure and effect, yet the ability of measures to produce a valid and reliable understanding of the effects of DTC advertising can be improved. Our review provides a framework for conceptualizing DTC measurement, and can be used to identify gaps in the literature not sufficiently addressed by existing measures. Researchers should continue to explore correlations between exposure and effect of DTC advertising, but are obliged to improve and validate measurement in this area.

  1. An approach to research on embodiment and forms of knowledge : methodological challenges for interpretation

    DEFF Research Database (Denmark)

    Knudsen, Lars Emmerik Damgaard

    argues. Studying a teacher training program, specifically the relation between placement and teaching, this presentation argues for a ‘meeting point’ and theoretical frame of Merleau-Ponty, Aristotle and Højrup that all dialectally grasps the relations between researcher and interviewee by understanding......Abstract: This paper is on the researcher’s role and the status of the data s/he is inclined to use. The outset is theories on embodied knowledge and knowledge forms such as Pierre Bourdieu, Hubert & Stuart Dreyfus and Jean Lave who all have troubles of how to view embodiment from either...... them as either bodily interwoven, life-mode or virtuously related. The inclusion of subjective perspectives and cultural conditions enlightens educational research as a process of interpretation where the embodied and life mode structured observation both opens and closes ways of interpretation...

  2. Methodological quality and descriptive characteristics of prosthodontic-related systematic reviews.

    Science.gov (United States)

    Aziz, T; Compton, S; Nassar, U; Matthews, D; Ansari, K; Flores-Mir, C

    2013-04-01

    Ideally, healthcare systematic reviews (SRs) should be beneficial to practicing professionals in making evidence-based clinical decisions. However, the conclusions drawn from SRs are directly related to the quality of the SR and of the included studies. The aim was to investigate the methodological quality and key descriptive characteristics of SRs published in prosthodontics. Methodological quality was analysed using the Assessment of Multiple Reviews (AMSTAR) tool. Several electronic resources (MEDLINE, EMBASE, Web of Science and American Dental Association's Evidence-based Dentistry website) were searched. In total 106 SRs were located. Key descriptive characteristics and methodological quality features were gathered and assessed, and descriptive and inferential statistical testing performed. Most SRs in this sample originated from the European continent followed by North America. Two to five authors conducted most SRs; the majority was affiliated with academic institutions and had prior experience publishing SRs. The majority of SRs were published in specialty dentistry journals, with implant or implant-related topics, the primary topics of interest for most. According to AMSTAR, most quality aspects were adequately fulfilled by less than half of the reviews. Publication bias and grey literature searches were the most poorly adhered components. Overall, the methodological quality of the prosthodontic-related systematic was deemed limited. Future recommendations would include authors to have prior training in conducting SRs and for journals to include a universal checklist that should be adhered to address all key characteristics of an unbiased SR process. © 2013 Blackwell Publishing Ltd.

  3. Definition of a shortcut methodology for assessing flood-related Na-Tech risk

    Directory of Open Access Journals (Sweden)

    E. Marzo

    2012-11-01

    Full Text Available In this paper a qualitative methodology for the initial assessment of flood-related Na-Tech risk was developed as a screening tool to identify which situations require a much more expensive quantitative risk analysis (QRA. Through the definition of some suitable key hazard indicators (KHIs, the proposed methodology allows the identification of the Na-Tech risk level associated with a given situation; the analytical hierarchy process (AHP was used as a multi-criteria decision tool for the evaluation of such qualitative KHIs. The developed methodology was validated through two case studies by comparing the predicted risk levels with the results of much more detailed QRAs previously presented in literature and then applied to the real flood happened at Spolana a.s., Neratovice, Czech Republic in August 2002.

  4. Overcoming etch challenges related to EUV based patterning (Conference Presentation)

    Science.gov (United States)

    Metz, Andrew W.; Cottle, Hongyun; Honda, Masanobu; Morikita, Shinya; Kumar, Kaushik A.; Biolsi, Peter

    2017-04-01

    Research and development activities related to Extreme Ultra Violet [EUV] defined patterning continue to grow for cost and extreme process control challenges of Self-Aligned Quad Patterning [SAQP] with continued momentum for EUV ecosystem readiness could provide cost advantages in addition to improved intra-level overlay performance relative to multiple patterning approaches. However, Line Edge Roughness [LER] and Line Width Roughness [LWR] performance of EUV defined resist images are still far from meeting technology needs or ITRS spec performance. Furthermore, extreme resist height scaling to mitigate flop over exacerbates the plasma etch trade-offs related to traditional approaches of PR smoothing, descum implementation and maintaining 2D aspect ratios of short lines or elliptical contacts concurrent with ultra-high photo resist [PR] selectivity. In this paper we will discuss sources of LER/LWR, impact of material choice, integration, and innovative plasma process techniques and describe how TELTM VigusTM CCP Etchers can enhance PR selectivity, reduce LER/LWR, and maintain 2D aspect ratio of incoming patterns. Beyond traditional process approaches this paper will show the utility of: [1] DC Superposition in enhancing EUV resist hardening and selectivity, increasing resistance to stress induced PR line wiggle caused by CFx passivation, and mitigating organic planarizer wiggle; [2] Quasi Atomic Layer Etch [Q-ALE] for ARC open eliminating the tradeoffs between selectivity, CD, and shrink ratio control; and [3] ALD+Etch FUSION technology for feature independent CD shrink and LER reduction. Applicability of these concepts back transferred to 193i based lithography is also confirmed.

  5. Research and Development Projects with ICT and students as learning designers in Primary Schools: A methodological challenge

    DEFF Research Database (Denmark)

    Levinsen, Karin Ellen Tweddell; Sørensen, Birgitte Holm; Tosca, Susana

    of how: • ICT supports students learning, • ICT release time for more teaching, and • teachers digital literacy impact on the role of ICT in the educational practice. Further the call required collaboration between universities and university colleges in order to disseminate knowledge and new practices......In this paper we present some methodological challenges that emerged during the process of shaping the research design for the comprehensive and complex research project Children as learning designers in a digital school. The project is the realization of our proposal to a research call from...... the Danish Ministry of Education named Development projects and pilot school experiments (Udviklingsprojekter med demonstrationsskoleforsøg vedr. it i folkeskolen – see Undervisningsministeriet 2013) in the spring 2013. The call was based on a governmental decision to allocate 500 million DKR to increase...

  6. [Would you mind a little bit less? Methodological and ethical challenges posed by the reduction of overtreatment].

    Science.gov (United States)

    Strech, Daniel

    2013-01-01

    The present paper outlines two central challenges that should be taken into account when making a concerted effort to reduce excessive medical care (overdiagnosis and overtreatment): first, the inevitability of value judgements in the risk-benefit assessment of medical treatment measures in conjunction with the need to go beyond the individual doctor-patient relationship and make these value judgements while, at least in part, assuming the role of acting deputy; and second, the need for a sufficient level of competence and trust in evidence-based medicine on the part of both physicians and patients. The paper will explain how one can say in a methodologically reasonable and ethically acceptable manner that a certain medical measure - in the context of the regular care setting - will objectively cause a "net harm" to the patient. Relevant institutions in the German healthcare system will be described that are currently conducting risk-benefit assessments (by different means and with different purposes). Taking the known entity of clinical guidelines as an example, the paper will demonstrate that the subjects of overdiagnosis and overtreatment as well as shortage of medical care can be more explicitly communicated by employing certain additional methodological tools. Finally, some central implementation barriers to a successful application of "Less is more!" will be presented and critically discussed. (As supplied by publisher). Copyright © 2013. Published by Elsevier GmbH.

  7. A stale challenge to the philosophy of science: commentary on "Is psychology based on a methodological error?" by Michael Schwarz.

    Science.gov (United States)

    Ruck, Nora; Slunecko, Thomas

    2010-06-01

    In his article "Is psychology based on a methodological error?" and based on a quite convincing empirical basis, Michael Schwarz offers a methodological critique of one of mainstream psychology's key test theoretical axioms, i.e., that of the in principle normal distribution of personality variables. It is characteristic of this paper--and at first seems to be a strength of it--that the author positions his critique within a frame of philosophy of science, particularly positioning himself in the tradition of Karl Popper's critical rationalism. When scrutinizing Schwarz's arguments, however, we find Schwarz's critique profound only as an immanent critique of test theoretical axioms. We raise doubts, however, as to Schwarz's alleged 'challenge' to the philosophy of science because the author not at all seems to be in touch with the state of the art of contemporary philosophy of science. Above all, we question the universalist undercurrent that Schwarz's 'bio-psycho-social model' of human judgment boils down to. In contrast to such position, we close our commentary with a plea for a context- and culture sensitive philosophy of science.

  8. Methodologies Developed for EcoCity Related Projects: New Borg El Arab, an Egyptian Case Study

    Directory of Open Access Journals (Sweden)

    Carmen Antuña-Rozado

    2016-08-01

    Full Text Available The aim of the methodologies described here is to propose measures and procedures for developing concepts and technological solutions, which are adapted to the local conditions, to build sustainable communities in developing countries and emerging economies. These methodologies are linked to the EcoCity framework outlined by VTT Technical Research Centre of Finland Ltd. for sustainable community and neighbourhood regeneration and development. The framework is the result of a long experience in numerous EcoCity related projects, mainly Nordic and European in scope, which has been reformulated in recent years to respond to the local needs in the previously mentioned countries. There is also a particular emphasis on close collaboration with local partners and major stakeholders. In order to illustrate how these methodologies can support EcoCity concept development and implementation, results from a case study in Egypt will be discussed. The referred case study relates to the transformation of New Borg El Arab (NBC, near Alexandria, into an EcoCity. The viability of the idea was explored making use of different methodologies (Roadmap, Feasibility Study, and Residents Energy Survey and Building Consumption Assessment and considering the Residential, Commercial/Public Facilities, Industrial, Services/Utilities, and Transport sectors.

  9. Overcoming methodological challenges in evaluating health communication campaigns: evidence from rural Bangladesh.

    Science.gov (United States)

    Guilkey, David K; Hutchinson, Paul L

    2011-06-01

    In this study, we examine the effectiveness of the Smiling Sun multimedia health communication campaign in encouraging women to use family health services in rural Bangladesh. We control for endogenous program placement and address the potential endogeneity of self-reported campaign exposure in health-behavior equations by estimating a set of exposure, contraceptive-use, and antenatal-care equations by full information maximum likelihood (FIML). We find that evaluation methods that do not take into account these nonrandom characteristics of communication and program exposure may produce underestimates of program benefits. Relative to the exposure effect of 3.7 percentage points in the simple model of contraceptive use, the exposure effect in the FIML model is a larger 5.5 percentage points, corresponding to as many as 40,000 additional contraceptive users. We conclude that evaluations of health communication campaigns would benefit from methods such as estimation by FIML that address nonrandom exposure and program targeting.

  10. Brief report on a systematic review of youth violence prevention through media campaigns: Does the limited yield of strong evidence imply methodological challenges or absence of effect?

    Science.gov (United States)

    Cassidy, Tali; Bowman, Brett; McGrath, Chloe; Matzopoulos, Richard

    2016-10-01

    We present a brief report on a systematic review which identified, assessed and synthesized the existing evidence of the effectiveness of media campaigns in reducing youth violence. Search strategies made use of terms for youth, violence and a range of terms relating to the intervention. An array of academic databases and websites were searched. Although media campaigns to reduce violence are widespread, only six studies met the inclusion criteria. There is little strong evidence to support a direct link between media campaigns and a reduction in youth violence. Several studies measure proxies for violence such as empathy or opinions related to violence, but the link between these measures and violence perpetration is unclear. Nonetheless, some evidence suggests that a targeted and context-specific campaign, especially when combined with other measures, can reduce violence. However, such campaigns are less cost-effective to replicate over large populations than generalised campaigns. It is unclear whether the paucity of evidence represents a null effect or methodological challenges with evaluating media campaigns. Future studies need to be carefully planned to accommodate for methodological difficulties as well as to identify the specific elements of campaigns that work, especially in lower and middle income countries. Copyright © 2016 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

  11. A semi-automated methodology for finding lipid-related GO terms.

    Science.gov (United States)

    Fan, Mengyuan; Low, Hong Sang; Wenk, Markus R; Wong, Limsoon

    2014-01-01

    Although semantic similarity in Gene Ontology (GO) and other approaches may be used to find similar GO terms, there is yet a method to systematically find a class of GO terms sharing a common property with high accuracy (e.g., involving human curation). We have developed a methodology to address this issue and applied it to identify lipid-related GO terms, owing to the important and varied roles of lipids in many biological processes. Our methodology finds lipid-related GO terms in a semi-automated manner, requiring only moderate manual curation. We first obtain a list of lipid-related gold-standard GO terms by keyword search and manual curation. Then, based on the hypothesis that co-annotated GO terms share similar properties, we develop a machine learning method that expands the list of lipid-related terms from the gold standard. Those terms predicted most likely to be lipid related are examined by a human curator following specific curation rules to confirm the class labels. The structure of GO is also exploited to help reduce the curation effort. The prediction and curation cycle is repeated until no further lipid-related term is found. Our approach has covered a high proportion, if not all, of lipid-related terms with relatively high efficiency. http://compbio.ddns.comp.nus.edu.sg/∼lipidgo. © The Author(s) 2014. Published by Oxford University Press.

  12. Defining the Enterovirus Diversity Landscape of a Fecal Sample: A Methodological Challenge?

    Science.gov (United States)

    Faleye, Temitope Oluwasegun Cephas; Adewumi, Moses Olubusuyi; Adeniji, Johnson Adekunle

    2016-01-12

    Enteroviruses are a group of over 250 naked icosahedral virus serotypes that have been associated with clinical conditions that range from intrauterine enterovirus transmission withfataloutcome through encephalitis and meningitis, to paralysis. Classically, enterovirus detection was done by assaying for the development of the classic enterovirus-specific cytopathic effect in cell culture. Subsequently, the isolates were historically identified by a neutralization assay. More recently, identification has been done by reverse transcriptase-polymerase chain reaction (RT-PCR). However, in recent times, there is a move towards direct detection and identification of enteroviruses from clinical samples using the cell culture-independent RT semi-nested PCR (RT-snPCR) assay. This RT-snPCR procedure amplifies the VP1 gene, which is then sequenced and used for identification. However, while cell culture-based strategies tend to show a preponderance of certain enterovirus species depending on the cell lines included in the isolation protocol, the RT-snPCR strategies tilt in a different direction. Consequently, it is becoming apparent that the diversity observed in certain enterovirus species, e.g., enterovirus species B(EV-B), might not be because they are the most evolutionarily successful. Rather, it might stem from cell line-specific bias accumulated over several years of use of the cell culture-dependent isolation protocols. Furthermore, it might also be a reflection of the impact of the relative genome concentration on the result of pan-enterovirus VP1 RT-snPCR screens used during the identification of cell culture isolates. This review highlights the impact of these two processes on the current diversity landscape of enteroviruses and the need to re-assess enterovirus detection and identification algorithms in a bid to better balance our understanding of the enterovirus diversity landscape.

  13. Jog Your Mind: methodology and challenges of conducting evaluative research in partnership with community organizations.

    Science.gov (United States)

    Bier, Nathalie; Lorthios-Guilledroit, Agathe; Nour, Kareen; Parisien, Manon; Ellemberg, Dave; Laforest, Sophie

    2015-01-01

    Jog Your Mind is a community-based program aiming at empowering elderly people to maintain their cognitive abilities using a multi-strategic approach including cognitively stimulating activities, mnemonic strategies, and strategies to promote healthy behaviors. It is offered to elderly individuals without known or diagnosed cognitive impairment by volunteers or community practitioners over ten weekly sessions. This paper describes the protocol of a quasi-experimental study designed to evaluate Jog Your Mind. Community responsible to recruit participants were either assigned to the experimental group (participating in the Jog Your Mind program) or to the control group (one-year waiting list). All participants were interviewed at baseline (T1), after the program (T2), and 12 months after the baseline (T3). Primary outcomes were the use of everyday memory strategies and aids and subjective memory functioning in daily life. Secondary outcomes included attitudes, knowledge, and behaviors related to cognitive vitality and cognitive abilities (memory and executive functions). Program delivery, organizational and environmental variables were recorded to document the implementation process. Twenty-three community organizations recruited 294 community-dwelling elderly individuals in total at T1. Between T1 and T3, an attrition rate of 15.2% was obtained. Jog Your Mind is one of the only programs targeting cognition among older adults being offered in community settings by community practitioners. The protocol described was designed with a focus on maximizing broad generalizations of the results while achieving scientific rigor. It can serve as an example to guide future research aiming to evaluate health interventions under natural conditions.

  14. 2015 QuickCompass of Sexual Assult-Related Responders: Statistical Methodology Report

    Science.gov (United States)

    2016-02-01

    Degree Age CAGE5 18 to 24 years olds 25 to 30 years olds 31 to 34 years olds 35 to 40 years olds 41 years old and older Gender CSEX Male Female...2015 QuickCompass of Sexual Assault Prevention and Response- Related Responders Statistical Methodology Report Additional copies of this report...from: http://www.dtic.mil/ Ask for report by ADA630235 DMDC Report No. 2015-039 February 2016 2015 QUICKCOMPASS OF SEXUAL ASSAULT PREVENTION

  15. Application of project management methodology in design management of nuclear safety related structure

    International Nuclear Information System (INIS)

    Chen Mao

    2004-01-01

    This paper focuses on the application of project management methodology in the design management of Nuclear Safety Related Structure (NSRS), considering the design management features of its civil construction. Based on the experiences from the management of several projects, the project management triangle is proposed to be used in the management, to well treat the position of design interface in the project management. Some other management methods are also proposed

  16. Work-Related Stress Risk Assessment in Italy: A Methodological Proposal Adapted to Regulatory Guidelines

    Directory of Open Access Journals (Sweden)

    Benedetta Persechino

    2013-06-01

    Conclusion: This methodological proposal is new on the Italian work-related stress risk assessment scene. Besides providing an evaluation approach using scientifically validated instruments, it ensures the active participation of occupational health professionals in each company. The assessment tools provided enable companies not only to comply with the law, but also to contribute to a database for monitoring and assessment and give access to a reserved area for data analysis and comparisons.

  17. Methodological and theoretical issues in the comparative analysis of gender relations in Western Europe

    OpenAIRE

    S Walby

    1994-01-01

    The aim in this paper is to contribute to the development of a research agenda for the comparative analysis of gender relations in Western Europe. Its focus is the clarification of the methodological and theoretical issues involved. Several different indices of gender inequality are assessed. It is argued that it is important to distinguish between the form and degree of patriarchy, rather than assuming that these are closely associated. Data from the EC and Scandinavia are used to illustrate...

  18. The Adequacy of the Q Methodology for Clinical Validation of Nursing Diagnoses Related to Subjective Foci.

    Science.gov (United States)

    Miguel, Susana; Caldeira, Sílvia; Vieira, Margarida

    2018-04-01

    This article describes the adequacy of the Q methodology as a new option for the validation of nursing diagnoses related to subjective foci. Discussion paper about the characteristics of the Q methodology. This method has been used in nursing research particularly related to subjective concepts and includes both a quantitative and qualitative dimension. The Q methodology seems to be an adequate and innovative method for the clinical validation of nursing diagnoses. The validation of nursing diagnoses related to subjective foci using the Q methodology could improve the level of evidence and provide nurses with clinical indicators for clinical reasoning and for the planning of effective interventions. Descrever a adequação da metodologia Q como uma nova opção para a validação clínica de diagnósticos de enfermagem relacionados com focos subjetivos. MÉTODOS: Artigo de discussão sobre as características da metodologia Q. Este método tem sido utilizado na pesquisa em enfermagem relacionada com conceitos subjetivos e inclui em simultâneo uma vertente qualitativa e quantitativa. CONCLUSÕES: A metodologia Q parece ser uma opção metodológica adequada para a validação clínica de diagnósticos de enfermagem. IMPLICAÇÕES PARA A PRÁTICA: A utilização da metodologia Q na validação clínica de diagnósticos de enfermagem relacionados com focos subjetivos pode melhorar o nível e evidência e facilitar o raciocínio clínico dos enfermeiros, ao providenciar indicadores clínicos também necessários ao desenvolvimento de intervenções efetivas. © 2016 NANDA International, Inc.

  19. Some Theoretical and Methodological Problems Related to Studying the Future of Adult Education

    Directory of Open Access Journals (Sweden)

    Ilija Lavrnja

    1995-12-01

    Full Text Available The following paper first discusses some epistemological and theoretically methodological initial theses for a futurological research in education. In analysing them, the author first dwells upon different orientations and doctrines for futuro logical research work (rational detenninism and indetenninism, agnosticism and probabil· ism. This article is focusing upon possibilities and limits of hypotheses, related to the educational development in the future. In doing so, re-orientation or reconstruction of knowledge, educational phenomena and pedagogical thinking related to the education as a factor inducing individual and social development are taken into account.

  20. HIV Risks, Testing, and Treatment in the Former Soviet Union: Challenges and Future Directions in Research and Methodology.

    Science.gov (United States)

    Saadat, Victoria M

    2015-01-01

    The dissolution of the USSR resulted in independence for constituent republics but left them battling an unstable economic environment and healthcare. Increases in injection drug use, prostitution, and migration were all widespread responses to this transition and have contributed to the emergence of an HIV epidemic in the countries of former Soviet Union. Researchers have begun to identify the risks of HIV infection as well as the barriers to HIV testing and treatment in the former Soviet Union. Significant methodological challenges have arisen and need to be addressed. The objective of this review is to determine common threads in HIV research in the former Soviet Union and provide useful recommendations for future research studies. In this systematic review of the literature, Pubmed was searched for English-language studies using the key search terms "HIV", "AIDS", "human immunodeficiency virus", "acquired immune deficiency syndrome", "Central Asia", "Kazakhstan", "Kyrgyzstan", "Uzbekistan", "Tajikistan", "Turkmenistan", "Russia", "Ukraine", "Armenia", "Azerbaijan", and "Georgia". Studies were evaluated against eligibility criteria for inclusion. Thirty-nine studies were identified across the two main topic areas of HIV risk and barriers to testing and treatment, themes subsequently referred to as "risk" and "barriers". Study design was predominantly cross-sectional. The most frequently used sampling methods were peer-to-peer and non-probabilistic sampling. The most frequently reported risks were condom misuse, risky intercourse, and unsafe practices among injection drug users. Common barriers to testing included that testing was inconvenient, and that results would not remain confidential. Frequent barriers to treatment were based on a distrust in the treatment system. The findings of this review reveal methodological limitations that span the existing studies. Small sample size, cross-sectional design, and non-probabilistic sampling methods were frequently

  1. A review of multi-risk methodologies for natural hazards: Consequences and challenges for a climate change impact assessment.

    Science.gov (United States)

    Gallina, Valentina; Torresan, Silvia; Critto, Andrea; Sperotto, Anna; Glade, Thomas; Marcomini, Antonio

    2016-03-01

    This paper presents a review of existing multi-risk assessment concepts and tools applied by organisations and projects providing the basis for the development of a multi-risk methodology in a climate change perspective. Relevant initiatives were developed for the assessment of multiple natural hazards (e.g. floods, storm surges, droughts) affecting the same area in a defined timeframe (e.g. year, season, decade). Major research efforts were focused on the identification and aggregation of multiple hazard types (e.g. independent, correlated, cascading hazards) by means of quantitative and semi-quantitative approaches. Moreover, several methodologies aim to assess the vulnerability of multiple targets to specific natural hazards by means of vulnerability functions and indicators at the regional and local scale. The overall results of the review show that multi-risk approaches do not consider the effects of climate change and mostly rely on the analysis of static vulnerability (i.e. no time-dependent vulnerabilities, no changes among exposed elements). A relevant challenge is therefore to develop comprehensive formal approaches for the assessment of different climate-induced hazards and risks, including dynamic exposure and vulnerability. This requires the selection and aggregation of suitable hazard and vulnerability metrics to make a synthesis of information about multiple climate impacts, the spatial analysis and ranking of risks, including their visualization and communication to end-users. To face these issues, climate impact assessors should develop cross-sectorial collaborations among different expertise (e.g. modellers, natural scientists, economists) integrating information on climate change scenarios with sectorial climate impact assessment, towards the development of a comprehensive multi-risk assessment process. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Challenge and Error: Critical Events and Attention-Related Errors

    Science.gov (United States)

    Cheyne, James Allan; Carriere, Jonathan S. A.; Solman, Grayden J. F.; Smilek, Daniel

    2011-01-01

    Attention lapses resulting from reactivity to task challenges and their consequences constitute a pervasive factor affecting everyday performance errors and accidents. A bidirectional model of attention lapses (error [image omitted] attention-lapse: Cheyne, Solman, Carriere, & Smilek, 2009) argues that errors beget errors by generating attention…

  3. Factors Relating to Staff Attributions of Control over Challenging Behaviour

    Science.gov (United States)

    Dilworth, Jennifer A.; Phillips, Neil; Rose, John

    2011-01-01

    Background: Previous research has suggested that severity of intellectual disability (ID) and topography of behaviour may influence staff causal attributions regarding challenging behaviour. Subsequently, these causal attributions may influence helping behaviours. This study investigated the relationship between attributions of control over…

  4. Work-related stress risk assessment in Italy: a methodological proposal adapted to regulatory guidelines.

    Science.gov (United States)

    Persechino, Benedetta; Valenti, Antonio; Ronchetti, Matteo; Rondinone, Bruna Maria; Di Tecco, Cristina; Vitali, Sara; Iavicoli, Sergio

    2013-06-01

    Work-related stress is one of the major causes of occupational ill health. In line with the regulatory framework on occupational health and safety (OSH), adequate models for assessing and managing risk need to be identified so as to minimize the impact of this stress not only on workers' health, but also on productivity. After close analysis of the Italian and European reference regulatory framework and work-related stress assessment and management models used in some European countries, we adopted the UK Health and Safety Executive's (HSE) Management Standards (MS) approach, adapting it to the Italian context in order to provide a suitable methodological proposal for Italy. We have developed a work-related stress risk assessment strategy, meeting regulatory requirements, now available on a specific web platform that includes software, tutorials, and other tools to assist companies in their assessments. This methodological proposal is new on the Italian work-related stress risk assessment scene. Besides providing an evaluation approach using scientifically validated instruments, it ensures the active participation of occupational health professionals in each company. The assessment tools provided enable companies not only to comply with the law, but also to contribute to a database for monitoring and assessment and give access to a reserved area for data analysis and comparisons.

  5. Methodology of teaching and new challenges in the training of professionals in the area of industrial radiology

    International Nuclear Information System (INIS)

    Lima, C.M. Araujo; Pelegrineli, S.Q.; Lima, A.R.

    2017-01-01

    One of the main causes of radiological accidents is the lack of knowledge in radiological protection of workers. In order to meet the needs of professionals in radiology techniques in training in industrial radiology and radiological protection, the Training Course in Industrial Radiology was created in 2009 by MAXIM, in partnership with the Casa Branca Faculty. The objective is to present the structure and methodology of teaching used in this course to reach the objectives of training professionals with solid knowledge in industrial radiology, as well as to mention the challenges of this training. For the elaboration of the study, a statistical data base and theoretical analysis of the teaching structure of the course was used. Professional training in industrial radiology is subdivided into basic, specific, practical and complementary modules, totaling a workload of 360 hours. It is noted that most of the professionals trained come from the great urban centers of the country, favoring employability in the port terminals and industries that are located in these regions. It is concluded, therefore, that it is necessary and of great importance for the growing industrial market, the formation of new professionals, mainly in cities of the interior

  6. A pragmatic trial in the Rio de Janeiro subway to capture smokers for a quitline: methodological challenges and opportunities.

    Science.gov (United States)

    Szklo, André Salem; da Silva Freire Coutinho, Evandro; Reichenheim, Michael Eduardo

    2012-01-01

    According to the World Health Organization, smoking is an important cause of death worldwide. To encourage smoking cessation, persuasive messages can be used to raise smokers' risk perception. This article discusses challenges and solutions in designing a study to evaluate the effect of two different communication strategies ("gains from quitting" vs. "losses from continuing smoking") in encouraging calls to a quitline. The authors conducted an intervention study in two subway stations for 4 weeks, considering only 1 strategy per station. Large posters containing non-age-specific images and texts, on the basis of the theme"shortness of breath," were displayed on central dividing columns on the boarding platforms. Call rates from the selected stations, and respective rate ratios, overall and per study week, were calculated. Passengers who were smokers, exposed to the positive-content message, called on average 1.7 times more often than did those exposed to the negative-content message (p = .01). Moreover, call rate ratios did not decline over the 4 weeks of the study (p = .40). The effectiveness findings suggest that antismoking campaigns could use positive-content messages in order to recruit a larger smoker population. The proposed methodology can also be used to evaluate effectiveness of messages for "capturing" individuals with other health problems (e.g., alcohol abuse), thereby increasing its potential impact.

  7. Pragmatic critical realism: could this methodological approach expand our understanding of employment relations?

    Science.gov (United States)

    Mearns, Susan Lesley

    2011-01-01

    This paper seeks to highlight the need for employment relations academics and researchers to expand their use of research methodologies in order for them to enable the advancement of theoretical debate within their discipline. It focuses on the contribution that pragmatical critical realism has made to the field of perception and argues that it would add value to the subject of employment relations. It is a theoretically centred review of pragmatical critical realism and the possible contribution this methodology would make to the field of employment relations. The paper concludes that the employment relationship does not take place in a vacuum rather it is focussed on the interaction between imperfect individuals. Therefore, their interactions are moulded by emotions which can not be explored thoroughly or even acknowledged through a positivists' rigorous but limited acknowledgment of what constitutes 'knowledge' and development of theory. While not rejecting the contribution that quantitative data or positivism have made to the field, the study concludes that pragmatic critical realism has a lot to offer the development of the area and its theoretical foundations.

  8. Nurses' perceptions of the challenges related to the Omanization policy.

    Science.gov (United States)

    Al-Riyami, M; Fischer, I; Lopez, V

    2015-12-01

    Human resource development has become a major concern in Oman since the inception of the 'Omanization' policy in 1988. The main goal of this policy was to replace the expatriate nursing workforce with similarly qualified local nurses to develop a sustainable workforce and achieve self-reliance. The aim of this study is to explore the nurses' perceptions of Omanization policy. A qualitative research design was used and 16 Omani registered nurses and 26 student nurses were interviewed in depth. Transcribed data were analysed using content analysis. Two main themes emerged from the data: 'Challenges of sustaining the local nursing workforce' and 'Challenges of educational preparation for local nurses'. The participants agreed that Omanization benefited national development, social stability and ensuring local workforce. The challenges faced were cultural and work life balance, preparation of nurses and pace of replacement. The participants were concerned that the pace of replacement could leave behind a marked experience gap. A slow-phased approach to Omanization of the nursing workforce was recommended by the participants. Results obtained from this study reflect the perceptions and voices of student nurses and registered nurses only from the Institute of Nursing and Oman Ministry of Health. A policy of this magnitude requires gradual establishment. The upgrading of the nursing education to degree level, continuous professional development, mentoring and role modeling of expert nurses should be established to prepare local nurses for the localization of the nursing workforce. © 2015 International Council of Nurses.

  9. Adaptation and development of software simulation methodologies for cardiovascular engineering: present and future challenges from an end-user perspective.

    Science.gov (United States)

    Díaz-Zuccarini, V; Narracott, A J; Burriesci, G; Zervides, C; Rafiroiu, D; Jones, D; Hose, D R; Lawford, P V

    2009-07-13

    This paper describes the use of diverse software tools in cardiovascular applications. These tools were primarily developed in the field of engineering and the applications presented push the boundaries of the software to address events related to venous and arterial valve closure, exploration of dynamic boundary conditions or the inclusion of multi-scale boundary conditions from protein to organ levels. The future of cardiovascular research and the challenges that modellers and clinicians face from validation to clinical uptake are discussed from an end-user perspective.

  10. [Methodological and operational notes for the assessment and management of the risk of work-related stress].

    Science.gov (United States)

    De Ambrogi, Francesco; Ratti, Elisabetta Ceppi

    2011-01-01

    Today the Italian national debate over the Work-Related Stress Risk Assessment methodology is rather heated. Several methodological proposals and guidelines have been published in recent months, not least those by the "Commissione Consultiva". But despite this wide range of proposals, it appears that there is still a lack of attention to some of the basic methodological issues that must be taken into account in order to correctly implement the above-mentioned guidelines. The aim of this paper is to outline these methodological issues. In order to achieve this, the most authoritative methodological proposals and guidelines have been reviewed. The study focuses in particular on the methodological issues that could lead to important biases if not considered properly. The study leads to some considerations about the methodological validity of a Work-Related Stress Risk Assessment based exclusively on the literal interpretation of the considered proposals. Furthermore, the study provides some hints and working hypotheses on how to overcome these methodological limits. This study should be considered as a starting point for further investigations and debate on the Work-Related Stress Risk Assessment methodology on a national level.

  11. HIV Risks, Testing, and Treatment in the Former Soviet Union: Challenges and Future Directions in Research and Methodology

    Directory of Open Access Journals (Sweden)

    Victoria M. Saadat

    2016-01-01

    Full Text Available Background. The dissolution of the USSR resulted in independence for constituent republics but left them battling an unstable economic environment and healthcare. Increases in injection drug use, prostitution, and migration were all widespread responses to this transition and have contributed to the emergence of an HIV epidemic in the countries of former Soviet Union. Researchers have begun to identify the risks of HIV infection as well as the barriers to HIV testing and treatment in the former Soviet Union. Significant methodological challenges have arisen and need to be addressed. The objective of this review is to determine common threads in HIV research in the former Soviet Union and provide useful recommendations for future research studies.Methods. In this systematic review of the literature, Pubmed was searched for English-language studies using the key search terms “HIV”, “AIDS”, “human immunodeficiency virus”, “acquired immune deficiency syndrome”, “Central Asia”, “Kazakhstan”, “Kyrgyzstan”, “Uzbekistan”, “Tajikistan”, “Turkmenistan”, “Russia”, “Ukraine”, “Armenia”, “Azerbaijan”, and “Georgia”. Studies were evaluated against eligibility criteria for inclusion.Results. Thirty-nine studies were identified across the two main topic areas of HIV risk and barriers to testing and treatment, themes subsequently referred to as “risk” and “barriers”. Study design was predominantly cross-sectional. The most frequently used sampling methods were peer-to-peer and non-probabilistic sampling. The most frequently reported risks were condom misuse, risky intercourse, and unsafe practices among injection drug users.  Common barriers to testing included that testing was inconvenient, and that results would not remain confidential.  Frequent barriers to treatment were based on a distrust in the treatment system. Conclusion. The findings of this review reveal methodological limitations

  12. Big data related technologies, challenges and future prospects

    CERN Document Server

    Chen, Min; Zhang, Yin; Leung, Victor CM

    2014-01-01

    This Springer Brief provides a comprehensive overview of the background and recent developments of big data. The value chain of big data is divided into four phases: data generation, data acquisition, data storage and data analysis. For each phase, the book introduces the general background, discusses technical challenges and reviews the latest advances. Technologies under discussion include cloud computing, Internet of Things, data centers, Hadoop and more. The authors also explore several representative applications of big data such as enterprise management, online social networks, healthcar

  13. Searches for Higgsinos and related challenges in ATLAS

    CERN Document Server

    Mete, Alaettin Serhan; The ATLAS collaboration

    2018-01-01

    Natural models of Supersymmetry (SUSY) typically favour existence of light Higgsinos. Models in which the only accessible SUSY particles are charginos and neutralinos that are predominantly Higgsinos tend to have low mass splitting between these particles. Such models, commonly referred to as compressed models, lead to final states including low-momentum leptons and disappearing tracks that are experimentally challenging to characterise. In this proceeding, the latest results from Higgsino searches that are conducted taking advantage of the large $pp$ collision dataset recorded by ATLAS in 2015 and 2016 at a centre-of-mass energy of 13 TeV are presented.

  14. Searches for Higgsinos and related challenges in ATLAS

    CERN Document Server

    Mete, Alaettin Serhan; The ATLAS collaboration

    2018-01-01

    Natural models of Supersymmetry (SUSY) typically favor existence of light higgsinos. Models in which the only accessible SUSY particles are charginos and neutralinos that are predominantly higgsinos tend to have low mass splitting between these particles. Such models, commonly referred to as compressed models, lead to final states including low-momentum leptons and disappearing tracks that are experimentally challenging to characterize. This talk will present the latest results from Higgsino searches that are conducted taking advantage of the large pp collision dataset recorded by ATLAS in 2015 and 2016 at a centre-of-mass energy of 13 TeV.

  15. Development of a quantitative methodology to assess the impacts of urban transport interventions and related noise on well-being

    NARCIS (Netherlands)

    Braubach, M.; Tobollik, M.; Mudu, P.; Hiscock, R.; Chapizanis, D.; Sarigiannis, D.A.; Keuken, M.; Perez, L.; Martuzzi, M.

    2015-01-01

    Well-being impact assessments of urban interventions are a difficult challenge, as there is no agreed methodology and scarce evidence on the relationship between environmental conditions and well-being. The European Union (EU) project “Urban Reduction of Greenhouse Gas Emissions in China and Europe”

  16. The glycemic index: methodological aspects related to the interpretation of health effects and to regulatory labeling.

    Science.gov (United States)

    Aziz, Alfred

    2009-01-01

    The glycemic index (GI) is an experimental system that classifies carbohydrates (CHO) and CHO-containing foods according to their blood glucose-raising potential. It is based on the glycemic response following the ingestion of a test food containing a defined amount of available CHO relative to that of an equi-carbohydrate portion of either white bread or glucose. The concept has been extended to mixed meals and whole diets where the GI of the meal/diet is expressed as the weighted average of the GI of each food, based on the percentage of the total mealldiet CHO provided by each food. Over the last few decades, a substantial number of epidemiological and interventional studies have reported beneficial associationsleffects of lower GI diets across a wide spectrum of pathophysiological conditions, including diabetes, cardiovascular disease, obesity, and certain forms of cancer. This has prompted proponents of the GI to recommend its use for dietary planning and labeling purposes. However, the currently recommended GI methodology is not well standardized and has several flaws, which brings into question the strength of evidence attributed to the health effects of low-GI diets. This review focuses exclusively on the methodological aspects of the GI, how they might impact the interpretation of data related to the purported health benefits of low GI diets, and the considerations for the use of the GI in food labeling. In addition, alternative systems for classifying the glycemic effects of CHO-containing foods are briefly discussed.

  17. Methodological and Design Considerations in Evaluating the Impact of Prevention Programs on Violence and Related Health Outcomes.

    Science.gov (United States)

    Massetti, Greta M; Simon, Thomas R; Smith, Deborah Gorman

    2016-10-01

    Drawing on research that has identified specific predictors and trajectories of risk for violence and related negative outcomes, a multitude of small- and large-scale preventive interventions for specific risk behaviors have been developed, implemented, and evaluated. One of the principal challenges of these approaches is that a number of separate problem-specific programs targeting different risk areas have emerged. However, as many negative health behaviors such as substance abuse and violence share a multitude of risk factors, many programs target identical risk factors. There are opportunities to understand whether evidence-based programs can be leveraged for potential effects across a spectrum of outcomes and over time. Some recent work has documented longitudinal effects of evidence-based interventions on generalized outcomes. This work has potential for advancing our understanding of the effectiveness of promising and evidence-based prevention strategies. However, conducting longitudinal follow-up of established interventions presents a number of methodological and design challenges. To answer some of these questions, the Centers for Disease Control and Prevention convened a panel of multidisciplinary experts to discuss opportunities to take advantage of evaluations of early prevention programs and evaluating multiple long-term outcomes. This special section of the journal Prevention Science includes a series of papers that begin to address the relevant considerations for conducting longitudinal follow-up evaluation research. This collection of papers is intended to inform our understanding of the challenges and strategies for conducting longitudinal follow-up evaluation research that could be used to drive future research endeavors.

  18. Methodological Adaptations for Investigating the Perceptions of Language-Impaired Adolescents Regarding the Relative Importance of Selected Communication Skills

    Science.gov (United States)

    Reed, Vicki A.; Brammall, Helen

    2006-01-01

    This article describes the systematic and detailed processes undertaken to modify a research methodology for use with language-impaired adolescents. The original methodology had been used previously with normally achieving adolescents and speech pathologists to obtain their opinions about the relative importance of selected communication skills…

  19. Methodological challenges in following up patients of a hospital child protection team: is there a recruitment bias?

    Directory of Open Access Journals (Sweden)

    Lips Ulrich

    2010-11-01

    Full Text Available Abstract Background The aims of this study are to describe the methodological challenges in recruiting a follow-up sample of children referred to an interdisciplinary hospital child protection team (CPT and to compare participating versus non-participating groups on several demographic variables and maltreatment characteristics. Methods Of the 319 in- and outpatients referred to the CPT at University Children's Hospital Zurich from 2005–2006 a sample of 180 children was drawn to contact for a follow-up. The children and their parents were asked to participate in a face-to-face interview at the hospital; in 42 cases the children and parents consented to do so. Alternatively, the parents could take part in a telephone interview (n = 39. Non-participation resulted because no contact or adequate communication in German, French, or English could be established (n = 49 or because the parents or children refused to participate (n = 50. Results Participants and non-participants did not differ significantly in mean child age at follow-up, gender, family status, place of residence, certainty and type of maltreatment, and type of perpetrator. However, the child's nationality had a significant impact: Percentages of foreign nationals were higher in the fully participating group (45%; n = 19 and the non-contactable group (53%; n = 26 and significantly lower in the refusal (26%; n = 10 and the telephone interview group (18%; n = 9. Although a high percentage of families had moved in the few years since the CPT intervention (32%; n = 57, the percentage of moves was not significantly higher in non-participants compared to participants. Conclusions Further research is needed to support these results in different national backgrounds and to test for biases in variables not included – especially socioeconomic status. This includes gathering more detailed information on non-participants, while respecting ethical boundaries. Overall, the fact that only child

  20. A nationwide study on reproductive function, ovarian reserve, and risk of premature menopause in female survivors of childhood cancer: design and methodological challenges

    Directory of Open Access Journals (Sweden)

    Overbeek Annelies

    2012-08-01

    Full Text Available Abstract Background Advances in childhood cancer treatment over the past decades have significantly improved survival, resulting in a rapidly growing group of survivors. However, both chemo- and radiotherapy may adversely affect reproductive function. This paper describes the design and encountered methodological challenges of a nationwide study in the Netherlands investigating the effects of treatment on reproductive function, ovarian reserve, premature menopause and pregnancy outcomes in female childhood cancer survivors (CCS, the DCOG LATER-VEVO study. Methods The study is a retrospective cohort study consisting of two parts: a questionnaire assessing medical, menstrual, and obstetric history, and a clinical assessment evaluating ovarian and uterine function by hormonal analyses and transvaginal ultrasound measurements. The eligible study population consists of adult female 5-year survivors of childhood cancer treated in the Netherlands, whereas the control group consists of age-matched sisters of the participating CCS. To date, study invitations have been sent to 1611 CCS and 429 sister controls, of which 1215 (75% and 333 (78% have responded so far. Of these responders, the majority consented to participate in both parts of the study (53% vs. 65% for CCS and sister controls respectively. Several challenges were encountered involving the study population: dealing with bias due to the differences in characteristics of several types of (non- participants and finding an adequately sized and well-matched control group. Moreover, the challenges related to the data collection process included: differences in response rates between web-based and paper-based questionnaires, validity of self-reported outcomes, interpretation of clinical measurements of women using hormonal contraceptives, and inter- and intra-observer variation of the ultrasound measurements. Discussion The DCOG LATER-VEVO study will provide valuable information about the

  1. A case study of career related challenges of expatriate Indian professionals in the GCC countries.

    OpenAIRE

    Naithani, Pranav

    2013-01-01

    The success of an overseas employment contract is significantly influenced by career related challenges. This paper presents the findings of a primary research conducted in the three GCC countries (Bahrain, Oman and the UAE) to comprehend the key career related challenges faced by professional Indian expatriates. This paper also explores the influence of demographic factors on career related challenges and concludes with the analysis of overall findings.

  2. A case study of career related challenges of expatriate Indian professionals in the GCC countries

    OpenAIRE

    Naithani, Pranav

    2013-01-01

    The success of an overseas employment contract is significantly influenced by career related challenges. This paper presents the findings of a primary research conducted in the three GCC countries (Bahrain, Oman and the UAE) to comprehendthe key career related challenges faced by professional Indian expatriates. This paper also explores the influence of demographic factors on career related challenges and concludes with the analysis of overall findings.

  3. EVALUATION OF RELATIVE GEOMETRIC ACCURACY OF TERRASAR-X BY PIXEL MATCHING METHODOLOGY

    Directory of Open Access Journals (Sweden)

    T. Nonaka

    2016-06-01

    Full Text Available Recently, high-resolution commercial SAR satellites with several meters of resolutions are widely utilized for various applications and disaster monitoring is one of the commonly applied areas. The information about the flooding situation and ground displacement was rapidly announced to the public after the Great East Japan Earthquake 2011. One of the studies reported the displacement in Tohoku region by the pixel matching methodology using both pre- and post- event TerraSAR-X data, and the validated accuracy was about 30 cm at the GEONET reference points. In order to discuss the spatial distribution of the displacement, we need to evaluate the relative accuracy of the displacement in addition to the absolute accuracy. In the previous studies, our study team evaluated the absolute 2D geo-location accuracy of the TerraSAR-X ortho-rectified EEC product for both flat and mountain areas. Therefore, the purpose of the current study was to evaluate the spatial and temporal relative geo-location accuracies of the product by considering the displacement of the fixed point as the relative geo-location accuracy. Firstly, by utilizing TerraSAR-X StripMap dataset, the pixel matching method for estimating the displacement with sub-pixel level was developed. Secondly, the validity of the method was confirmed by comparing with GEONET data. We confirmed that the accuracy of the displacement for X and Y direction was in agreement with the previous studies. Subsequently, the methodology was applied to 20 pairs of data set for areas of Tokyo Ota-ku and Kawasaki-shi, and the displacement of each pair was evaluated. It was revealed that the time series displacement rate had the seasonal trend and seemed to be related to atmospheric delay.

  4. Evaluation of Relative Geometric Accuracy of Terrasar-X by Pixel Matching Methodology

    Science.gov (United States)

    Nonaka, T.; Asaka, T.; Iwashita, K.

    2016-06-01

    Recently, high-resolution commercial SAR satellites with several meters of resolutions are widely utilized for various applications and disaster monitoring is one of the commonly applied areas. The information about the flooding situation and ground displacement was rapidly announced to the public after the Great East Japan Earthquake 2011. One of the studies reported the displacement in Tohoku region by the pixel matching methodology using both pre- and post- event TerraSAR-X data, and the validated accuracy was about 30 cm at the GEONET reference points. In order to discuss the spatial distribution of the displacement, we need to evaluate the relative accuracy of the displacement in addition to the absolute accuracy. In the previous studies, our study team evaluated the absolute 2D geo-location accuracy of the TerraSAR-X ortho-rectified EEC product for both flat and mountain areas. Therefore, the purpose of the current study was to evaluate the spatial and temporal relative geo-location accuracies of the product by considering the displacement of the fixed point as the relative geo-location accuracy. Firstly, by utilizing TerraSAR-X StripMap dataset, the pixel matching method for estimating the displacement with sub-pixel level was developed. Secondly, the validity of the method was confirmed by comparing with GEONET data. We confirmed that the accuracy of the displacement for X and Y direction was in agreement with the previous studies. Subsequently, the methodology was applied to 20 pairs of data set for areas of Tokyo Ota-ku and Kawasaki-shi, and the displacement of each pair was evaluated. It was revealed that the time series displacement rate had the seasonal trend and seemed to be related to atmospheric delay.

  5. Determination of cadmium relative bioavailability in contaminated soils and its prediction using in vitro methodologies.

    Science.gov (United States)

    Juhasz, Albert L; Weber, John; Naidu, Ravi; Gancarz, Dorota; Rofe, Allan; Todor, Damian; Smith, Euan

    2010-07-01

    In this study, cadmium (Cd) relative bioavailability in contaminated (n = 5) and spiked (n = 2) soils was assessed using an in vivo mouse model following administration of feed containing soil or Cd acetate (reference material) over a 15 day exposure period. Cadmium relative bioavailability varied depending on whether the accumulation of Cd in the kidneys, liver, or kidney plus liver was used for relative bioavailability calculations. When kidney plus liver Cd concentrations were used, Cd relative bioavailability ranged from 10.1 to 92.1%. Cadmium relative bioavailability was higher (14.4-115.2%) when kidney Cd concentrations were used, whereas lower values (7.2-76.5%) were derived when liver Cd concentrations were employed in calculations. Following in vivo studies, four in vitro methodologies (SBRC, IVG, PBET, and DIN), encompassing both gastric and intestinal phases, were assessed for their ability to predict Cd relative bioavailability. Pearson correlations demonstrated a strong linear relationship between Cd relative bioavailability and Cd bioaccessibility (0.62-0.91), however, stronger in vivo-in vitro relationships were observed when Cd relative bioavailability was calculated using kidney plus liver Cd concentrations. Whereas all in vitro assays could predict Cd relative bioavailability with varying degrees of confidence (r(2) = 0.348-0.835), large y intercepts were calculated for a number of in vitro assays which is undesirable for in vivo-in vitro predictive models. However, determination of Cd bioaccessibility using the intestinal phase of the PBET assay resulted in a small y intercept (5.14; slope =1.091) and the best estimate of in vivo Cd relative bioavailability (r(2) = 0.835).

  6. Mothers’ non-standard working and childcare-related challenges : A comparison between lone and coupled mothers

    OpenAIRE

    Moilanen, Sanna; May, Vanessa; Räikkönen, Eija; Sevón, Eija; Laakso, Marja-Leena

    2016-01-01

    Purpose – The purpose of this paper is to particularly focus on lone-mother families, comparing the childcare-related challenges experienced by working lone mothers and coupled mothers in three European countries in the context of a 24/7 economy and non-standard working hours (e.g. evening, night and weekend work). Design/methodology/approach – This study utilises survey data from Finnish, Dutch and British working mothers (n=1,106) collected as part of the “Families 24/7” research ...

  7. A methodological approach for the biomechanical cause analysis of golf-related lumbar spine injuries.

    Science.gov (United States)

    Sim, Taeyong; Jang, Dong-Jin; Oh, Euichaul

    2014-01-01

    A new methodological approach employing mechanical work (MW) determination and relative portion of its elemental analysis was applied to investigate the biomechanical causes of golf-related lumbar spine injuries. Kinematic and kinetic parameters at the lumbar and lower limb joints were measured during downswing in 18 golfers. The MW at the lumbar joint (LJ) was smaller than at the right hip but larger than the MWs at other joints. The contribution of joint angular velocity (JAV) to MW was much greater than that of net muscle moment (NMM) at the LJ, whereas the contribution of NMM to MW was greater rather than or similar to that of JAV at other joints. Thus, the contribution of JAV to MW is likely more critical in terms of the probability of golf-related injury than that of NMM. The MW-based golf-related injury index (MWGII), proposed as the ratio of the contribution of JAV to MW to that of NMM, at the LJ (1.55) was significantly greater than those at other joints ( golf-related injuries around the lumbar spine. Therefore, both MW and MWGII should be considered when investigating the biomechanical causes of lumbar spine injuries.

  8. The Practices and Challenges of Public Relations within Two ...

    African Journals Online (AJOL)

    Prof

    public relations within the organizations in Harar and Dire Dawa towns, pertinent to .... Different theoretical models and concepts exist regarding the roles and function of ..... 65% are urban inhabitants, and 35 % rural inhabitants. The region is ...

  9. Accelerant-related burns and drug abuse: Challenging combination.

    Science.gov (United States)

    Leung, Leslie T F; Papp, Anthony

    2018-05-01

    Accelerants are flammable substances that may cause explosion when added to existing fires. The relationships between drug abuse and accelerant-related burns are not well elucidated in the literature. Of these burns, a portion is related to drug manufacturing, which have been shown to be associated with increased burn complications. 1) To evaluate the demographics and clinical outcomes of accelerant-related burns in a Provincial Burn Centre. 2) To compare the clinical outcomes with a control group of non-accelerant related burns. 3) To analyze a subgroup of patients with history of drug abuse and drug manufacturing. Retrospective case control study. Patient data associated with accelerant-related burns from 2009 to 2014 were obtained from the British Columbia Burn Registry. These patients were compared with a control group of non-accelerant related burns. Clinical outcomes that were evaluated include inhalational injury, ICU length of stay, ventilator support, surgeries needed, and burn complications. Chi-square test was used to evaluate categorical data and Student's t-test was used to evaluate mean quantitative data with the p value set at 0.05. A logistic regression model was used to evaluate factors affecting burn complications. Accelerant-related burns represented 28.2% of all burn admissions (N=532) from 2009 to 2014. The accelerant group had higher percentage of patients with history of drug abuse and was associated with higher TBSA burns, ventilator support, ICU stay and pneumonia rates compared to the non-accelerant group. Within the accelerant group, there was no difference in clinical outcomes amongst people with or without history of drug abuse. Four cases were associated with methamphetamine manufacturing, all of which underwent ICU stay and ventilator support. Accelerant-related burns cause significant burden to the burn center. A significant proportion of these patients have history of drug abuse. Copyright © 2017 Elsevier Ltd and ISBI. All rights

  10. A systematic review of studies on psychosocial late effects of childhood cancer: structures of society and methodological pitfalls may challenge the conclusions

    DEFF Research Database (Denmark)

    Lund, Lasse Wegener; Schmiegelow, Kjeld; Rechnitzer, Catherine

    2011-01-01

    High survival rates after childhood cancer raise attention to possible psychosocial late effects. We focus on predictors of psychosocial outcomes based on diagnosis, treatment, demography, somatic disease, and methodological problems. Overall, survivors evaluate their health-related quality of life...

  11. Stress-Related Growth in Two Challenging Conditions

    Czech Academy of Sciences Publication Activity Database

    Šolcová, Iva; Tavel, P.

    2017-01-01

    Roč. 13, č. 1 (2017), č. článku 4. ISSN 1529-5168 Institutional support: RVO:68081740 Keywords : Mars-500 * cruise * personal growth * spirituality, cognitive growth * social growth Subject RIV: AN - Psychology OBOR OECD: Psychology (including human - machine relations)

  12. India-EU relations in health services: prospects and challenges

    Science.gov (United States)

    2011-01-01

    Background India and the EU are currently negotiating a Trade and Investment Agreement which also covers services. This paper examines the opportunities for and constraints to India-EU relations in health services in the context of this agreement, focusing on the EU as a market for India's health services exports and collaboration. The paper provides an overview of key features of health services in the EU and India and their bearing on bilateral relations in this sector. Methods Twenty six semi-structured, in-person, and telephonic interviews were conducted in 2007-2008 in four Indian cities. The respondents included management and practitioners in a variety of healthcare establishments, health sector representatives in Indian industry associations, health sector officials in the Indian government, and official representatives of selected EU countries and the European Commission based in New Delhi. Secondary sources were used to supplement and corroborate these findings. Results The interviews revealed that India-EU relations in health services are currently very limited. However, several opportunity segments exist, namely: (i) Telemedicine; (ii) Clinical trials and research in India for EU-based pharmaceutical companies; (iii) Medical transcriptions and back office support; (iv) Medical value travel; and (v) Collaborative ventures in medical education, research, training, staff deployment, and product development. However, various factors constrain India's exports to the EU. These include data protection regulations; recognition requirements; insurance portability restrictions; discriminatory conditions; and cultural, social, and perception-related barriers. The interviews also revealed several constraints in the Indian health care sector, including disparity in domestic standards and training, absence of clear guidelines and procedures, and inadequate infrastructure. Conclusions The paper concludes that although there are several promising areas for India

  13. India-EU relations in health services: prospects and challenges

    Directory of Open Access Journals (Sweden)

    Chanda Rupa

    2011-02-01

    Full Text Available Abstract Background India and the EU are currently negotiating a Trade and Investment Agreement which also covers services. This paper examines the opportunities for and constraints to India-EU relations in health services in the context of this agreement, focusing on the EU as a market for India's health services exports and collaboration. The paper provides an overview of key features of health services in the EU and India and their bearing on bilateral relations in this sector. Methods Twenty six semi-structured, in-person, and telephonic interviews were conducted in 2007-2008 in four Indian cities. The respondents included management and practitioners in a variety of healthcare establishments, health sector representatives in Indian industry associations, health sector officials in the Indian government, and official representatives of selected EU countries and the European Commission based in New Delhi. Secondary sources were used to supplement and corroborate these findings. Results The interviews revealed that India-EU relations in health services are currently very limited. However, several opportunity segments exist, namely: (i Telemedicine; (ii Clinical trials and research in India for EU-based pharmaceutical companies; (iii Medical transcriptions and back office support; (iv Medical value travel; and (v Collaborative ventures in medical education, research, training, staff deployment, and product development. However, various factors constrain India's exports to the EU. These include data protection regulations; recognition requirements; insurance portability restrictions; discriminatory conditions; and cultural, social, and perception-related barriers. The interviews also revealed several constraints in the Indian health care sector, including disparity in domestic standards and training, absence of clear guidelines and procedures, and inadequate infrastructure. Conclusions The paper concludes that although there are several

  14. Determination of the Relative Sediment Concentration in Water Bodies Using Remote Sensing Methodology

    Directory of Open Access Journals (Sweden)

    Germán Vargas Cuervo

    2017-01-01

    Full Text Available Studies for the determination of the relative concentration of sediments (RCS in bodies of water such as rivers, marshes and river deltas require specialized equipment, field work and laboratory analyses of samples, all with high economic costs. Remote sensing, in regions of the optical electromagnetic spectrum, particularly in the visible range between 0.4 and 0.6 µm, shows radiometric contrasts associated with the relative concentration of sediments in water bodies. This work presents an analysis of the principal spectral, spatial and radiometric properties or characteristics of remote sensors for the determination of the relative concentration of sediments in bodies of water, a methodological process for its cartography at a given time or an established period of time. This cartography is based on digital processing of images rather than direct measurements in the field. Lastly, applications are presented for the delta coast of the southwestern area of the Colombian Caribbean between Barranquilla and Punta Piedra and in the lacustrine area of the Guajaro Reservoir and the Jobo and Capote Wetlands in the upper Canal del Dique, Colombia.

  15. Understanding and Facing Discipline-Related Challenges in the English as a Foreign Language Classroom at Public Schools

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    Josefina Quintero Corzo

    2011-07-01

    Full Text Available Complying with school regulations and teachers' instructions is a basic principle of an excellent class; both novice and experienced teachers face challenging situations when getting into real classrooms, especially those related to classroom management. There are various reasons that explain discipline problems in public schools, as well as varied strategies beginning teachers create and try when coping with those challenges. This article reports an action research study on how this methodology helped a group of teacher-trainees overcome indiscipline in English as a foreign language classrooms at public schools, and align with professional development initiatives which focus on reflection and decision-making processes that the new Colombian policies demand from new teachers seeking a higher quality of education.

  16. Quantifying Averted Disability-Adjusted Life Years as a Performance Indicator for Water Quality Interventions: A Review of Current Methodologies and Challenges

    Directory of Open Access Journals (Sweden)

    Darcy M. Anderson

    2018-06-01

    Full Text Available Sustainable access to safe drinking water protects against infectious disease and promotes overall health. Despite considerable progress toward increasing water access, safe water quality and reliable service delivery remain a challenge. Traditional financing strategies pay implementers based on inputs and activities, with minimal incentives for water quality monitoring and sustained service operation. Pay-for-performance offers an alternative financing strategy that delivers all or a portion of payment based on performance indicators of desired outputs or outcomes. A pay-for-performance approach in the water sector could quantify and incentivize health impact. Averted disability-adjusted life years (ADALYs have been used as a performance indicator to measure the burden of disease averted due to environmental health interventions. Water-related disease burden can be measured for application as an ADALYs performance indicator following either comparative risk assessment or quantitative microbial risk assessment. Comparative risk assessment models disease burden using water source type as a proxy indicator of microbial water quality, while quantitative microbial risk assessment models disease burden using concentrations of indicator pathogens. This paper compares these risk assessment methodologies, and summarizes the limitations of applying these approaches toward quantifying ADALYs as a performance indicator for water quality interventions.

  17. Defence in front of challenges related to climate disruption

    International Nuclear Information System (INIS)

    Alex, Bastien

    2015-03-01

    As the Pentagon already noticed a relationship between security and climate change in a report published more than ten years ago, climate change is now considered as a threat multiplier, and is therefore a major stake for industrial, institutional and military actors of defence. The author first describes the relationship between national security and climatic security, how risks related to global warming have also an actual potential of destabilisation. He describes how this issue is increasingly addressed by defence actors, notably with a strategic approach initiated by the USA, a still holding back France, discussions about the impact of operational capabilities, and a trend for a carbon print decrease for the defence sector. In the next part, the author examines whether policies of adaptation to climate change could involve threats, evokes the development of geo-engineering, and briefly outlines that a failed adaptation could increase vulnerability

  18. Teaching methodologies to promote creativity in the professional skills related to optics knowledge

    Science.gov (United States)

    Fernández-Oliveras, Alicia; Fernandez, Paz; Peña-García, Antonio; Oliveras, Maria L.

    2014-07-01

    We present the methodologies proposed and applied in the context of a teaching-innovation project developed at the University of Granada, Spain. The main objective of the project is the implementation of teaching methodologies that promote the creativity in the learning process and, subsequently, in the acquisition of professional skills. This project involves two subjects related with optics knowledge in undergraduate students. The subjects are "Illumination Engineering" (Bachelor's degree in Civil-Engineering) and "Optical and Optometric Instrumentation" (Bachelor's degree in and Optics and Optometry). For the first subject, the activities of our project were carried out in the theoretical classes. By contrast, in the case of the second subject, such activities were designed for the laboratory sessions. For "Illumination Engineering" we applied the maieutic technique. With this method the students were encouraged to establish relationships between the main applications of the subject and concepts that apparently unrelated with the subject framework. By means of several examples, the students became aware of the importance of cross-curricular and lateral thinking. We used the technique based on protocols of control and change in "Optical and Optometric Instrumentation". The modus operandi was focused on prompting the students to adopt the role of the professionals and to pose questions to themselves concerning the practical content of the subject from that professional role. This mechanism boosted the critical capacity and the independent-learning ability of the students. In this work, we describe in detail both subject proposals and the results of their application in the 2011-2012 academic course.

  19. Urban sprawl, obesity, and cancer mortality in the United States: cross-sectional analysis and methodological challenges.

    Science.gov (United States)

    Berrigan, David; Tatalovich, Zaria; Pickle, Linda W; Ewing, Reid; Ballard-Barbash, Rachel

    2014-01-06

    Urban sprawl has the potential to influence cancer mortality via direct and indirect effects on obesity, access to health services, physical activity, transportation choices and other correlates of sprawl and urbanization. This paper presents a cross-sectional analysis of associations between urban sprawl and cancer mortality in urban and suburban counties of the United States. This ecological analysis was designed to examine whether urban sprawl is associated with total and obesity-related cancer mortality and to what extent these associations differed in different regions of the US. A major focus of our analyses was to adequately account for spatial heterogeneity in mortality. Therefore, we fit a series of regression models, stratified by gender, successively testing for the presence of spatial heterogeneity. Our resulting models included county level variables related to race, smoking, obesity, access to health services, insurance status, socioeconomic position, and broad geographic region as well as a measure of urban sprawl and several interactions. Our most complex models also included random effects to account for any county-level spatial autocorrelation that remained unexplained by these variables. Total cancer mortality rates were higher in less sprawling areas and contrary to our initial hypothesis; this was also true of obesity related cancers in six of seven U.S. regions (census divisions) where there were statistically significant associations between the sprawl index and mortality. We also found significant interactions (p urban sprawl for total and obesity related cancer mortality in both sexes. Thus, the association between urban sprawl and cancer mortality differs in different regions of the US. Despite higher levels of obesity in more sprawling counties in the US, mortality from obesity related cancer was not greater in such counties. Identification of disparities in cancer mortality within and between geographic regions is an ongoing public

  20. Methodology of radionuclides dis incorporation in people related to nuclear and radiological accidents

    International Nuclear Information System (INIS)

    Jimenez F, E. A.

    2014-01-01

    In this paper a classification of the radiological and nuclear accidents is presented, describing which the activities are, where they have occurred, their incidence and the learned lessons in these successes. The radiological accidents in which radioactive materials intervene can occur anywhere, and they are related to no controlled dangerous sources (abandoned, lost, stolen, or found sources), improper use of dangerous industrial and medical sources, exposition and contamination of people in general by an unknown origin, serious over expositions, menaces and willful misconduct, emergencies during transportation of radioactive material. A person can receive a dose of radiation from an external source, because of radioactive material placed on skin or on equipment, or because of ingestion or inhalation of radiological particles. The ingestion or the inhalation of radioactive material can cause an internal dose to the whole body or to a specific organ during a period of time. That is why a description of the processes of incorporation, the stages of incorporation and a description of the biokinetic models are also realized to understand the ingestion, transference and the excretion of the radioactive elements. In order to offer help to a victim of internal contamination, the dosimetric and medical diagnosis is very important. The most important techniques of dosimetric diagnosis are the dosimetry in vivo (cytogenetics and the counting in vivo of the whole body) and the bioassays. These techniques allow obtain data such as the radionuclide, the target organ, the absorbed dose, etc. At the same time, the doctor in charge must be attentive to the patients symptoms and their manifestation time, since they are an indicator, first, the patient suffered an irradiation, and second, of the range esteem of the received radiation dose. These are the parameters that are useful as criterion to decide if a person has to receive some treatment and select the methodologies that

  1. Health related war dioxin in Vietnam today, methodological approach in evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Thom, Le Hong; Tran, Manh Hung; Phung, Tri Dung [Ministry of Health, Ha Noi (Viet Nam)

    2004-09-15

    The Chemical war, that lasted for more than 10 years (1961-1971) had ended 30 years ago, but its severe outcomes on exposed human health seem to be far from ending. By the newest calculations, there should be more than 80 million of herbicides, including no less than 500 kg of Dioxin - 2,3,7,8-TCDD have been sprayed over land of South Vietnam. Dioxin the most ecotoxic agent, that human knowns to now, and have been researched by many scientists over the world. The studies conducted in experimental animals and partly in human tissues, have demonstrated, that dioxin cause the toxicity for many biofunctions, especially for systems like: nervous, digestive, immunoresponses, reproductive health, skin disorders, and carcinogenicity. It seems to be, that Viet nam have become a ''biggest laboratory'' of dioxin testing and its effects studying over the world. Many research into human health have been done, but the opinions of health outcomes, related to dioxin exposure still cause the debates. A lot of studies conducted on nature and man in Viet nam also, unfortunately there is not yet the overview general, concerning the methodological as epidemiological criteria. This report sum up the health, especially the reproductive outcomes, based strictly on the epidemiological disciplines.

  2. Methodological fragments for the planning and decision making related to library utomation projects

    Directory of Open Access Journals (Sweden)

    Wanda Maria Maia da Rocha Paranhos

    2004-01-01

    Full Text Available Library automation processes depend in part in taking decisions on aspects of information and communications technologies (ICTs such as operational software, application software, data base management systems, hardware and communication network. The process depend also on decisions taken on Library Science aspects, specially in relation to the creation and management of bibliographic data which support services provision, such as the funcionalities included in applications software and how software implement desirable standards. The more important standards are AACR2, MARC/XML, ISO2709 and z39.50 communication protocol. Commitment to those standards tend to impact favorably on projects final costs. The cost of construction bibliographic data base may be the more expensive element item in the whole project; that can be minimized with use of cited standards and free bibliographic information available in Internet. The bigger the library holding, the more expressive the economy on this item with this methodology, which allows for full observation of local guidelines for the database construction. A synthetic list of the variety of product solutions available in Brazil is presented appended to the article, as well as an example of a basic request list of items to observe or evaluate in integrated library systems.

  3. Scalable privacy-preserving data sharing methodology for genome-wide association studies: an application to iDASH healthcare privacy protection challenge.

    Science.gov (United States)

    Yu, Fei; Ji, Zhanglong

    2014-01-01

    In response to the growing interest in genome-wide association study (GWAS) data privacy, the Integrating Data for Analysis, Anonymization and SHaring (iDASH) center organized the iDASH Healthcare Privacy Protection Challenge, with the aim of investigating the effectiveness of applying privacy-preserving methodologies to human genetic data. This paper is based on a submission to the iDASH Healthcare Privacy Protection Challenge. We apply privacy-preserving methods that are adapted from Uhler et al. 2013 and Yu et al. 2014 to the challenge's data and analyze the data utility after the data are perturbed by the privacy-preserving methods. Major contributions of this paper include new interpretation of the χ2 statistic in a GWAS setting and new results about the Hamming distance score, a key component for one of the privacy-preserving methods.

  4. A methodological survey identified eight proposed frameworks for the adaptation of health related guidelines.

    Science.gov (United States)

    Darzi, Andrea; Abou-Jaoude, Elias A; Agarwal, Arnav; Lakis, Chantal; Wiercioch, Wojtek; Santesso, Nancy; Brax, Hneine; El-Jardali, Fadi; Schünemann, Holger J; Akl, Elie A

    2017-06-01

    five key steps strategy for adaptation of guidelines to the local context. The SGR method consists of nine steps and takes into consideration both methodological gaps and context-specific normative issues in source guidelines. We identified through searching personal files two abandoned methods. We identified and described eight proposed frameworks for the adaptation of health-related guidelines. There is a need to evaluate these different frameworks to assess rigor, efficiency, and transparency of their proposed processes. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Development of Geometry Optimization Methodology with In-house CFD code, and Challenge in Applying to Fuel Assembly

    International Nuclear Information System (INIS)

    Jeong, J. H.; Lee, K. L.

    2016-01-01

    The wire spacer has important roles to avoid collisions between adjacent rods, to mitigate a vortex induced vibration, and to enhance convective heat transfer by wire spacer induced secondary flow. Many experimental and numerical works has been conducted to understand the thermal-hydraulics of the wire-wrapped fuel bundles. There has been enormous growth in computing capability. Recently, a huge increase of computer power allows to three-dimensional simulation of thermal-hydraulics of wire-wrapped fuel bundles. In this study, the geometry optimization methodology with RANS based in-house CFD (Computational Fluid Dynamics) code has been successfully developed in air condition. In order to apply the developed methodology to fuel assembly, GGI (General Grid Interface) function is developed for in-house CFD code. Furthermore, three-dimensional flow fields calculated with in-house CFD code are compared with those calculated with general purpose commercial CFD solver, CFX. The geometry optimization methodology with RANS based in-house CFD code has been successfully developed in air condition. In order to apply the developed methodology to fuel assembly, GGI function is developed for in-house CFD code as same as CFX. Even though both analyses are conducted with same computational meshes, numerical error due to GGI function locally occurred in only CFX solver around rod surface and boundary region between inner fluid region and outer fluid region.

  6. From Study to Work: Methodological Challenges of a Graduate Destination Survey in the Western Cape, South Africa

    Science.gov (United States)

    du Toit, Jacques; Kraak, Andre; Favish, Judy; Fletcher, Lizelle

    2014-01-01

    Current literature proposes several strategies for improving response rates to student evaluation surveys. Graduate destination surveys pose the difficulty of tracing graduates years later when their contact details may have changed. This article discusses the methodology of one such a survey to maximise response rates. Compiling a sample frame…

  7. Trademarks in the Linguistic Landscape: Methodological and Theoretical Challenges in Qualifying Brand Names in the Public Space

    Science.gov (United States)

    Tufi, Stefania; Blackwood, Robert

    2010-01-01

    In the last few decades, investigations into the linguistic landscape (LL) have sought to analyse written language practices as they are observable in public space. Whilst the LL analysis of language choice in given contexts has opened a host of possibilities for scientific enquiry in the field, the methodologies employed in the collection and…

  8. UPCaD: A Methodology of Integration Between Ontology-Based Context-Awareness Modeling and Relational Domain Data

    Directory of Open Access Journals (Sweden)

    Vinícius Maran

    2018-01-01

    Full Text Available Context-awareness is a key feature for ubiquitous computing scenarios applications. Currently, technologies and methodologies have been proposed for the integration of context-awareness concepts in intelligent information systems to adapt them to the execution of services, user interfaces and data retrieval. Recent research proposed conceptual modeling alternatives to the integration of the domain modeling in RDBMS and context-awareness modeling. The research described using highly expressiveness ontologies. The present work describes the UPCaD (Unified Process for Integration between Context-Awareness and Domain methodology, which is composed of formalisms and processes to guide the data integration considering RDBMS and context modeling. The methodology was evaluated in a virtual learning environment application. The evaluation shows the possibility to use a highly expressive context ontology to filter the relational data query and discusses the main contributions of the methodology compared with recent approaches.

  9. Pregnancy-related hemophagocytic lymphohistiocytosis associated with cytomegalovirus infection: A diagnostic and therapeutic challenge

    Directory of Open Access Journals (Sweden)

    Nor Rafeah Tumian

    2015-08-01

    Conclusion: This case highlights the challenges and difficulties involved in the diagnosis and management of pregnancy-related HLH. Immunosuppressive treatment for HLH can precipitate life-threatening opportunistic infections, which need to be promptly diagnosed and treated.

  10. Legal Challenges Related to the Regulation of a Domain Name System

    Directory of Open Access Journals (Sweden)

    Marius Kalinauskas

    2012-12-01

    Full Text Available Purpose—to review and analyse the problematic aspects related to domain name allocation and further usage processes, highlighting legal regulation of a domain name system.Design/methodology/approach—based on the comparison analysis of scientific literature, authors discuss problematic issues related to the legal regulation of domain name allocation and usage processes, analyse practical approaches and collision cases in the context of a domain name system. The authors examine the positive and negative aspects of a domain naming system and conflicting regulatory specifics. This paper describes the development of institutional bodies responsible for DNS management, supervision approaches and inner functionality policies.Findings—the authors examine domain naming system models and dispute resolution mechanisms, their evolution in the context of Internet development and the structural changes of the Internet governance institutions. The authors analyse tendencies related to DNS regulation and the possible effect of new regulation models in practice, while reflecting interests of stakeholders in the subject field.Research limitations/implications—agreements on the registration of domain names are based on self-regulation principles. A number of different interests may collide when speaking about domain name registration or usage and this issue becomes a major challenge to scientists and lawyers who are seeking an optimal domain-naming regulatory mechanism. The article does not address trademark conflicts within domain names in this respect. This should be considered as an object for separate study, which requires deeper analysis.Practical implications—the authors review key aspects of the domain name system and describe tendencies for the regulatory models.Value—the article emphasizes potential domain naming conflicts and disputes concerning the usage of common terms and phrases in order to manipulate information for illicit purposes. The

  11. Legal Challenges Related to the Regulation of a Domain Name System

    Directory of Open Access Journals (Sweden)

    Marius Kalinauskas

    2013-02-01

    Full Text Available Purpose—to review and analyse the problematic aspects related to domain name allocation and further usage processes, highlighting legal regulation of a domain name system. Design/methodology/approach—based on the comparison analysis of scientific literature, authors discuss problematic issues related to the legal regulation of domain name allocation and usage processes, analyse practical approaches and collision cases in the context of a domain name system. The authors examine the positive and negative aspects of a domain naming system and conflicting regulatory specifics. This paper describes the development of institutional bodies responsible for DNS management, supervision approaches and inner functionality policies. Findings—the authors examine domain naming system models and dispute resolution mechanisms, their evolution in the context of Internet development and the structural changes of the Internet governance institutions. The authors analyse tendencies related to DNS regulation and the possible effect of new regulation models in practice, while reflecting interests of stakeholders in the subject field. Research limitations/implications—agreements on the registration of domain names are based on self-regulation principles. A number of different interests may collide when speaking about domain name registration or usage and this issue becomes a major challenge to scientists and lawyers who are seeking an optimal domain-naming regulatory mechanism. The article does not address trademark conflicts within domain names in this respect. This should be considered as an object for separate study, which requires deeper analysis. Practical implications—the authors review key aspects of the domain name system and describe tendencies for the regulatory models. Value—the article emphasizes potential domain naming conflicts and disputes concerning the usage of common terms and phrases in order to manipulate information for illicit purposes

  12. Do Italian Companies Manage Work-Related Stress Effectively? A Process Evaluation in Implementing the INAIL Methodology.

    Science.gov (United States)

    Di Tecco, Cristina; Ronchetti, Matteo; Ghelli, Monica; Russo, Simone; Persechino, Benedetta; Iavicoli, Sergio

    2015-01-01

    Studies on Intervention Process Evaluation are attracting growing attention in the literature on interventions linked to stress and the wellbeing of workers. There is evidence that some elements relating to the process and content of an intervention may have a decisive role in implementing it by facilitating or hindering the effectiveness of the results. This study aimed to provide a process evaluation on interventions to assess and manage risks related to work-related stress using a methodological path offered by INAIL. The final sample is composed of 124 companies participating to an interview on aspects relating to each phase of the INAIL methodological path put in place to implement the intervention. INAIL methodology has been defined as useful in the process of assessing and managing the risks related to work-related stress. Some factors related to the process (e.g., implementation of a preliminary phase, workers' involvement, and use of external consultants) showed a role in significant differences that emerged in the levels of risk, particularly in relation to findings from the preliminary assessment. Main findings provide information on the key aspects of process and content that are useful in implementing an intervention for assessing and managing risks related to work-related stress.

  13. Do Italian Companies Manage Work-Related Stress Effectively? A Process Evaluation in Implementing the INAIL Methodology

    Science.gov (United States)

    Di Tecco, Cristina; Ronchetti, Matteo; Ghelli, Monica; Russo, Simone; Persechino, Benedetta

    2015-01-01

    Studies on Intervention Process Evaluation are attracting growing attention in the literature on interventions linked to stress and the wellbeing of workers. There is evidence that some elements relating to the process and content of an intervention may have a decisive role in implementing it by facilitating or hindering the effectiveness of the results. This study aimed to provide a process evaluation on interventions to assess and manage risks related to work-related stress using a methodological path offered by INAIL. The final sample is composed of 124 companies participating to an interview on aspects relating to each phase of the INAIL methodological path put in place to implement the intervention. INAIL methodology has been defined as useful in the process of assessing and managing the risks related to work-related stress. Some factors related to the process (e.g., implementation of a preliminary phase, workers' involvement, and use of external consultants) showed a role in significant differences that emerged in the levels of risk, particularly in relation to findings from the preliminary assessment. Main findings provide information on the key aspects of process and content that are useful in implementing an intervention for assessing and managing risks related to work-related stress. PMID:26504788

  14. Exploration of Methodological and Participant-Related Influences on the Number of Artifacts in ERP Data

    Directory of Open Access Journals (Sweden)

    Stephanie M. Shields

    2017-11-01

    Full Text Available Event-related potential (ERP data has low signal-to-noise ratio, requiring the conduction of a large number of trials in order to collect sufficient amounts of data for subsequent analysis. Therefore, it would be highly beneficial if researchers could minimize the number of artifacts that occur in the data, minimizing the number of discarded trials and the total number of trials needed. This study thus examined connections between the number of trials that have to be eliminated due to artifacts and a set of methodological variables, physical considerations, and individual differences. In half of the electroencephalography (EEG data collection blocks, naïve undergraduate participants were asked not to blink for the duration of the block (approximately 2.5 minutes, but in the other half, the stimulus set included blinking cues to give participants a chance to blink during blocks. The number of artifacts did not differ based on whether participants were cued to blink during blocks nor which type of block participants experienced first. However, the first block had significantly more artifacts than other blocks, and the third block had significantly fewer. Participants who had previously known one or both investigators had significantly fewer artifacts in their data than participants who had not, but no significant relationship was found between the number of artifacts and any other individual difference or physical consideration examined. These results imply that researchers could preemptively reduce the number of artifacts in their EEG data by including practice blocks and recruiting friends or acquaintances for studies if possible. Based on subjective, unsolicited participant feedback, the authors also recommend having blink cues in data collection blocks in order to make the task more comfortable for participants. Future studies with similar aims could use different equipment setups, e.g. electrode caps, and experimental manipulation of

  15. An ensemble heterogeneous classification methodology for discovering health-related knowledge in social media messages.

    Science.gov (United States)

    Tuarob, Suppawong; Tucker, Conrad S; Salathe, Marcel; Ram, Nilam

    2014-06-01

    The role of social media as a source of timely and massive information has become more apparent since the era of Web 2.0.Multiple studies illustrated the use of information in social media to discover biomedical and health-related knowledge.Most methods proposed in the literature employ traditional document classification techniques that represent a document as a bag of words.These techniques work well when documents are rich in text and conform to standard English; however, they are not optimal for social media data where sparsity and noise are norms.This paper aims to address the limitations posed by the traditional bag-of-word based methods and propose to use heterogeneous features in combination with ensemble machine learning techniques to discover health-related information, which could prove to be useful to multiple biomedical applications, especially those needing to discover health-related knowledge in large scale social media data.Furthermore, the proposed methodology could be generalized to discover different types of information in various kinds of textual data. Social media data is characterized by an abundance of short social-oriented messages that do not conform to standard languages, both grammatically and syntactically.The problem of discovering health-related knowledge in social media data streams is then transformed into a text classification problem, where a text is identified as positive if it is health-related and negative otherwise.We first identify the limitations of the traditional methods which train machines with N-gram word features, then propose to overcome such limitations by utilizing the collaboration of machine learning based classifiers, each of which is trained to learn a semantically different aspect of the data.The parameter analysis for tuning each classifier is also reported. Three data sets are used in this research.The first data set comprises of approximately 5000 hand-labeled tweets, and is used for cross validation of the

  16. Interrelationships Between Receiver/Relative Operating Characteristics Display, Binomial, Logit, and Bayes' Rule Probability of Detection Methodologies

    Science.gov (United States)

    Generazio, Edward R.

    2014-01-01

    Unknown risks are introduced into failure critical systems when probability of detection (POD) capabilities are accepted without a complete understanding of the statistical method applied and the interpretation of the statistical results. The presence of this risk in the nondestructive evaluation (NDE) community is revealed in common statements about POD. These statements are often interpreted in a variety of ways and therefore, the very existence of the statements identifies the need for a more comprehensive understanding of POD methodologies. Statistical methodologies have data requirements to be met, procedures to be followed, and requirements for validation or demonstration of adequacy of the POD estimates. Risks are further enhanced due to the wide range of statistical methodologies used for determining the POD capability. Receiver/Relative Operating Characteristics (ROC) Display, simple binomial, logistic regression, and Bayes' rule POD methodologies are widely used in determining POD capability. This work focuses on Hit-Miss data to reveal the framework of the interrelationships between Receiver/Relative Operating Characteristics Display, simple binomial, logistic regression, and Bayes' Rule methodologies as they are applied to POD. Knowledge of these interrelationships leads to an intuitive and global understanding of the statistical data, procedural and validation requirements for establishing credible POD estimates.

  17. Thermal Protection for Mars Sample Return Earth Entry Vehicle: A Grand Challenge for Design Methodology and Reliability Verification

    Science.gov (United States)

    Venkatapathy, Ethiraj; Gage, Peter; Wright, Michael J.

    2017-01-01

    Mars Sample Return is our Grand Challenge for the coming decade. TPS (Thermal Protection System) nominal performance is not the key challenge. The main difficulty for designers is the need to verify unprecedented reliability for the entry system: current guidelines for prevention of backward contamination require that the probability of spores larger than 1 micron diameter escaping into the Earth environment be lower than 1 million for the entire system, and the allocation to TPS would be more stringent than that. For reference, the reliability allocation for Orion TPS is closer to 11000, and the demonstrated reliability for previous human Earth return systems was closer to 1100. Improving reliability by more than 3 orders of magnitude is a grand challenge indeed. The TPS community must embrace the possibility of new architectures that are focused on reliability above thermal performance and mass efficiency. MSR (Mars Sample Return) EEV (Earth Entry Vehicle) will be hit with MMOD (Micrometeoroid and Orbital Debris) prior to reentry. A chute-less aero-shell design which allows for self-righting shape was baselined in prior MSR studies, with the assumption that a passive system will maximize EEV robustness. Hence the aero-shell along with the TPS has to take ground impact and not break apart. System verification will require testing to establish ablative performance and thermal failure but also testing of damage from MMOD, and structural performance at ground impact. Mission requirements will demand analysis, testing and verification that are focused on establishing reliability of the design. In this proposed talk, we will focus on the grand challenge of MSR EEV TPS and the need for innovative approaches to address challenges in modeling, testing, manufacturing and verification.

  18. Culturally appropriate methodology in obtaining a representative sample of South Australian Aboriginal adults for a cross-sectional population health study: challenges and resolutions.

    Science.gov (United States)

    Marin, Tania; Taylor, Anne Winifred; Grande, Eleonora Dal; Avery, Jodie; Tucker, Graeme; Morey, Kim

    2015-05-19

    The considerably lower average life expectancy of Aboriginal and Torres Strait Islander Australians, compared with non-Aboriginal and non-Torres Strait Islander Australians, has been widely reported. Prevalence data for chronic disease and health risk factors are needed to provide evidence based estimates for Australian Aboriginal and Torres Strait Islanders population health planning. Representative surveys for these populations are difficult due to complex methodology. The focus of this paper is to describe in detail the methodological challenges and resolutions of a representative South Australian Aboriginal population-based health survey. Using a stratified multi-stage sampling methodology based on the Australian Bureau of Statistics 2006 Census with culturally appropriate and epidemiological rigorous methods, 11,428 randomly selected dwellings were approached from a total of 209 census collection districts. All persons eligible for the survey identified as Aboriginal and/or Torres Strait Islander and were selected from dwellings identified as having one or more Aboriginal person(s) living there at the time of the survey. Overall, the 399 interviews from an eligible sample of 691 SA Aboriginal adults yielded a response rate of 57.7%. These face-to-face interviews were conducted by ten interviewers retained from a total of 27 trained Aboriginal interviewers. Challenges were found in three main areas: identification and recruitment of participants; interviewer recruitment and retainment; and using appropriate engagement with communities. These challenges were resolved, or at least mainly overcome, by following local protocols with communities and their representatives, and reaching agreement on the process of research for Aboriginal people. Obtaining a representative sample of Aboriginal participants in a culturally appropriate way was methodologically challenging and required high levels of commitment and resources. Adhering to these principles has resulted in a

  19. Challenges and Possibilities of Implementation of the Inverted Classroom Methodology: Case Study in a Private Higher Education Institution

    Directory of Open Access Journals (Sweden)

    Paulo Rodrigues Milhorato

    2016-12-01

    Full Text Available Change is a word which characterizes the transition of the industrial society to the knowledge one. In this sense it is necessary to reevaluate the educational processes as well as the needing of nowadays society. In such scenery, it appears as a possibility the model proposed by Eric Mazur, during the 90ties, called inverted classroom. This model uses technology as a support to teaching. This article aims to describe the effects of the inverted classroom methodology in a Private IES. The methodology was based on a qualitative and quantitative research and used questionnaires available in google docs and/or printed matter, applied to the students of the Faculdade Pitágoras located in the Metropolitan area of Belo Horizonte, and also in interviews with teachers and a participating observation. Results show that the students’ profile is favorable to the use of inverted classroom model: they are young and in permanent contact with technology. Nevertheless, their daily routine, a deficient formation basis and the necessity to work in order to bear the cost of a private IES make quite complex the application of this model.

  20. Methodological Framework for Analysis of Buildings-Related Programs: The GPRA Metrics Effort

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, Douglas B.; Anderson, Dave M.; Belzer, David B.; Cort, Katherine A.; Dirks, James A.; Hostick, Donna J.

    2004-06-18

    The requirements of the Government Performance and Results Act (GPRA) of 1993 mandate the reporting of outcomes expected to result from programs of the Federal government. The U.S. Department of Energy’s (DOE’s) Office of Energy Efficiency and Renewable Energy (EERE) develops official metrics for its 11 major programs using its Office of Planning, Budget Formulation, and Analysis (OPBFA). OPBFA conducts an annual integrated modeling analysis to produce estimates of the energy, environmental, and financial benefits expected from EERE’s budget request. Two of EERE’s major programs include the Building Technologies Program (BT) and Office of Weatherization and Intergovernmental Program (WIP). Pacific Northwest National Laboratory (PNNL) supports the OPBFA effort by developing the program characterizations and other market information affecting these programs that is necessary to provide input to the EERE integrated modeling analysis. Throughout the report we refer to these programs as “buildings-related” programs, because the approach is not limited in application to BT or WIP. To adequately support OPBFA in the development of official GPRA metrics, PNNL communicates with the various activities and projects in BT and WIP to determine how best to characterize their activities planned for the upcoming budget request. PNNL then analyzes these projects to determine what the results of the characterizations would imply for energy markets, technology markets, and consumer behavior. This is accomplished by developing nonintegrated estimates of energy, environmental, and financial benefits (i.e., outcomes) of the technologies and practices expected to result from the budget request. These characterizations and nonintegrated modeling results are provided to OPBFA as inputs to the official benefits estimates developed for the Federal Budget. This report documents the approach and methodology used to estimate future energy, environmental, and financial benefits

  1. Methodologies Related to Computational models in View of Developing Anti-Alzheimer Drugs: An Overview.

    Science.gov (United States)

    Baheti, Kirtee; Kale, Mayura Ajay

    2018-04-17

    Since last two decades, there has been more focus on the development strategies related to Anti-Alzheimer's drug research. This may be attributed to the fact that most of the Alzheimer's cases are still mostly unknown except for a few cases, where genetic differences have been identified. With the progress of the disease, the symptoms involve intellectual deterioration, memory impairment, abnormal personality and behavioural patterns, confusion, aggression, mood swings, irritability Current therapies available for this disease give only symptomatic relief and do not focus on manipulations of biololecular processes. Nearly all the therapies to treat Alzheimer's disease, target to change the amyloid cascade which is considered to be an important in AD pathogenesis. New drug regimens are not able to keep pace with the ever-increasing understanding about dementia at molecular level. Looking into these aggravated problems, we though to put forth molecular modeling as a drug discovery approach for developing novel drugs to treat Alzheimer disease. The disease is incurable and it gets worst as it advances and finally causes death. Due to this, the design of drugs to treat this disease has become an utmost priority for research. One of the most important emerging technologies applied for this has been Computer-assisted drug design (CADD). It is a research tool that employs large scale computing strategies in an attempt to develop a model receptor site which can be used for designing of an anti-Alzheimer drug. The various models of amyloid-based calcium channels have been computationally optimized. Docking and De novo evolution are used to design the compounds. These are further subjected to absorption, distribution, metabolism, excretion and toxicity (ADMET) studies to finally bring about active compounds that are able to cross BBB. Many novel compounds have been designed which might be promising ones for the treatment of AD. The present review describes the research

  2. Daycare Staff Emotions and Coping Related to Children of Divorce: A Q Methodological Study

    Science.gov (United States)

    Øverland, Klara; Størksen, Ingunn; Bru, Edvin; Thorsen, Arlene Arstad

    2014-01-01

    This Q methodological study explores emotional experiences and coping of daycare staff when working with children of divorce and their families. Two main coping strategies among daycare staff were identified: 1) Confident copers, and 2) Non-confident copers. Interviews exemplify the two main experiences. Both groups may struggle with coping in…

  3. "To My Relations": Writing and Refusal toward an Indigenous Epistolary Methodology

    Science.gov (United States)

    Cisneros, Nora Alba

    2018-01-01

    In this article, the author presents an Indigenous Epistolary Methodology (IEM) to reflect on what it means for Indigenous women to engage the notion of refusal in traditional writing methods and qualitative research. The author proposes that an IEM, nestled within her familial genealogies, Indigenous Knowledges and Chicana Feminist Epistemology…

  4. Translating Oral Health-Related Quality of Life Measures: Are There Alternative Methodologies?

    Science.gov (United States)

    Brondani, Mario; He, Sarah

    2013-01-01

    Translating existing sociodental indicators to another language involves a rigorous methodology, which can be costly. Free-of-charge online translator tools are available, but have not been evaluated in the context of research involving quality of life measures. To explore the value of using online translator tools to develop oral health-related…

  5. Definition of a short-cut methodology for assessing earthquake-related Na-Tech risk

    International Nuclear Information System (INIS)

    Busini, Valentina; Marzo, Enrico; Callioni, Andrea; Rota, Renato

    2011-01-01

    Highlights: → In industrial sites located in natural hazard-prone areas technological accidents may be triggered by natural events, generating the so-called Na-Tech accidents. → In this paper, a qualitative screening methodology for assessing the earthquake Na-Tech risk has been developed with the aim of identifying which situations deserve a much more expensive Quantitative Risk Analysis. → The simple procedure developed, which summarizes in a suitable Key Hazard Indicator the Na-Tech risk level, has been validated by comparing its results with those of some Quantitative Risk Analyses involving also Na-Tech events and previously presented in the literature. - Abstract: Na-Tech (Natural and Technological) refers to industrial accidents triggered by natural events such as storms, earthquakes, flooding, and lightning. Herein, a qualitative methodology for the initial assessment of earthquake Na-Tech risk has been developed as a screening tool to identify which situations require a much more expensive Quantitative Risk Analysis (QRA). The proposed methodology, through suitable Key Hazard Indicators (KHIs), identifies the Na-Tech risk level associated with a given situation (i.e., a process plant located in a given territory), using the Analytical Hierarchy Process as a multi-criteria decision tool for the evaluation of such KHIs. The developed methodology was validated by comparing its computational results with QRA results that involved Na-Tech events previously presented in literature.

  6. The Challenge of Integrating OHS into Industrial Project Risk Management: Proposal of a Methodological Approach to Guide Future Research (Case of Mining Projects in Quebec, Canada

    Directory of Open Access Journals (Sweden)

    Adel Badri

    2015-06-01

    Full Text Available Although risk management tools are put to good use in many industrial sectors, some large projects have been met with numerous problems due to failure to take occupational health and safety (OHS into consideration. In spite of the high level of risk and uncertainty associated with many industrial projects, the number of studies of methods for managing all known risks systematically remains small. Under effervescent economic conditions, industries must meet several challenges associated with frequent project start-ups. In highly complex and uncertain environments, rigorous management of risk remains indispensable for avoiding threats to the success of projects. Many businesses seek continually to create and improve integrated approaches to risk management. This article puts into perspective the complexity of the challenge of integrating OHS into industrial project risk management. A conceptual and methodological approach is proposed to guide future research focused on meeting this challenge. The approach is based on applying multi-disciplinary research modes to a complex industrial context in order to identify all scenarios likely to contain threats to humans or the environment. A case study is used to illustrate the potential of the proposed approach for application and its contribution to meeting the challenge of taking OHS into consideration. On-site researchers were able to develop a new approach that helped two mining companies in Quebec (Canada to achieve successful integration of OHS into expansion projects.

  7. Methodological developments in qualitative longitudinal research: the advantages and challenges of regular telephone contact with participants in a qualitative longitudinal interview study.

    Science.gov (United States)

    Carduff, Emma; Murray, Scott A; Kendall, Marilyn

    2015-04-11

    Qualitative longitudinal research is an evolving methodology, particularly within health care research. It facilitates a nuanced understanding of how phenomena change over time and is ripe for innovative approaches. However, methodological reflections which are tailored to health care research are scarce. This article provides a synthesised and practical account of the advantages and challenges of maintaining regular telephone contact between interviews with participants in a qualitative longitudinal study. Participants with metastatic colorectal cancer were interviewed at 3 time points over the course of a year. Half the group also received monthly telephone calls to explore the added value and the feasibility of capturing change as close to when it was occurring as possible. The data gathered from the telephone calls added context to the participants' overall narrative and informed subsequent interviews. The telephone calls meant we were able to capture change close to when it happened and there was a more evolved, and involved, relationship between the researcher and the participants who were called on a monthly basis. However, ethical challenges were amplified, boundaries of the participant/researcher relationship questioned, and there was the added analytical burden. The telephone calls facilitated a more nuanced understanding of the illness experience to emerge, when compared with the interview only group. The findings suggest that intensive telephone contact may be justified if retention is an issue, when the phenomena being studied is unpredictable and when participants feel disempowered or lack control. These are potential issues for research involving participants with long-term illness.

  8. School-to-Work-Transition—Career Development and Family Planning: Methodological Guidelines and Challenges of a Qualitative Longitudinal Panel-Study

    Directory of Open Access Journals (Sweden)

    Thomas Kühn

    2000-06-01

    Full Text Available We are presenting the basic features of our qualitative German panel study concerning the job entry of young adults, dealing also with methodological issues. The selection of the respondents in qualified jobs (commercial-technical, crafts/trade, services took into account gender-specific aspects, different labor-market prospects and regions. From the quantitative panel, a theoretical sample of respondents was selected who were interviewed three times in three-years intervals (3 waves. These interviews, focusing on individual biographies (i.e. orientations and action strategies form the basis for constructing a typology. Methodological innovations concern the modeling of the sequence of occupational actions and orientations as life-course sequences and the case-specific and case-comparing analysis of interview transcripts. This was done—based on a data bank containing the interview material—by means of a detailed scheme of categories. The integration of quantitative and qualitative longitudinal data presents a theoretical and methodological challenge. Our focus is on biography and life-course research which suggests an interdisciplinary approach. URN: urn:nbn:de:0114-fqs0002178

  9. Ethics challenges and guidance related to research involving adolescent post-abortion care: a scoping review.

    Science.gov (United States)

    Zulu, Joseph M; Ali, Joseph; Hallez, Kristina; Kass, Nancy; Michelo, Charles; Hyder, Adnan A

    2018-05-02

    An increase in post abortion care (PAC) research with adolescents, particularly in low- and middle-income countries, has brought to attention several associated research ethics challenges. In order to better understand the ethics context of PAC research with adolescents, we conducted a scoping review of published literature. Following a systematic search of PubMed, HINARI, and Google Scholar, we analysed articles meeting inclusion criteria to determine common themes across both the ethical challenges related to PAC research with adolescents and any available guidance on the identified challenges. The literature search identified an initial 3321 records of which 14 were included in analysis following screening. Several ethical challenges stem from abortion being a controversial, sensitive, and stigmatized topic in many settings. Ethical dilemmas experienced by researchers conducting adolescent PAC research included: difficulties in convincing local health providers to permit PAC research; challenges in recruiting and seeking consent due to sensitivity of the subject; effectively protecting confidentiality; managing negative effects of interventions; creating a non-prejudicial atmosphere for research; managing emotional issues among adolescents; and dealing with uncertainty regarding the role of researchers when observing unethical health care practices. Suggested strategies for addressing some of these challenges include: using several sources to recruit study participants, using research to facilitate dialogue on abortion, briefing health workers on any observed unethical practices after data collection, fostering a comprehensive understanding of contextual norms and values, selecting staff with experience working with study populations, and avoiding collection of personal identifiers. Addressing ethical challenges that researchers face when conducting PAC research with adolescents requires guidance at the individual, institutional, community, and international

  10. BIG DATA-Related Challenges and Opportunities in Earth System Modeling

    Science.gov (United States)

    Bamzai, A. S.

    2012-12-01

    Knowledge of the Earth's climate has increased immensely in recent decades, both through observational analysis and modeling. BIG DATA-related challenges emerge in our quest for understanding the variability and predictability of the climate and earth system on a range of time scales, as well as in our endeavor to improve predictive capability using state-of-the-science models. To enable further scientific discovery, bottlenecks in current paradigms need to be addressed. An overview of current NSF activities in Earth System Modeling with a focus on associated data-related challenges and opportunities, will be presented.

  11. Interviews, Disclosures, and Misperceptions: Autistic Adults' Perspectives on Employment Related Challenges

    Directory of Open Access Journals (Sweden)

    Jennifer Sarrett

    2017-06-01

    Full Text Available As increasing numbers of autistic adults are seeking and gaining employment, the experiences of autistic adults in the workplace is critical to consider. Autistic adults encounter a range of challenges in obtaining and keeping employment and often report a range of negative experiences in the workplace. The current research reports the results from a large, national exploratory study on the experiences of autistic adults in the workplace as well as their thoughts on how to improve these experiences for the autism community. In particular, participants reported challenges with the interviewing process, which requires very specific and consistent social behaviors, as well as with feeling comfortable disclosing one's autistic status at work. These challenges are often connected with public misperceptions about autism. The article discusses these challenges as well as strategies to improve autism-related understanding and awareness in the workplace. This work is critical to conversations about diversity in the workplace.

  12. Can Neuroscience Contribute to Practical Ethics? A Critical Review and Discussion of the Methodological and Translational Challenges of the Neuroscience of Ethics.

    Science.gov (United States)

    Racine, Eric; Dubljević, Veljko; Jox, Ralf J; Baertschi, Bernard; Christensen, Julia F; Farisco, Michele; Jotterand, Fabrice; Kahane, Guy; Müller, Sabine

    2017-06-01

    Neuroethics is an interdisciplinary field that arose in response to novel ethical challenges posed by advances in neuroscience. Historically, neuroethics has provided an opportunity to synergize different disciplines, notably proposing a two-way dialogue between an 'ethics of neuroscience' and a 'neuroscience of ethics'. However, questions surface as to whether a 'neuroscience of ethics' is a useful and unified branch of research and whether it can actually inform or lead to theoretical insights and transferable practical knowledge to help resolve ethical questions. In this article, we examine why the neuroscience of ethics is a promising area of research and summarize what we have learned so far regarding its most promising goals and contributions. We then review some of the key methodological challenges which may have hindered the use of results generated thus far by the neuroscience of ethics. Strategies are suggested to address these challenges and improve the quality of research and increase neuroscience's usefulness for applied ethics and society at large. Finally, we reflect on potential outcomes of a neuroscience of ethics and discuss the different strategies that could be used to support knowledge transfer to help different stakeholders integrate knowledge from the neuroscience of ethics. © 2017 John Wiley & Sons Ltd.

  13. Methodology for evaluating gloves in relation to the effects on hand performance capabilities: a literature review.

    Science.gov (United States)

    Dianat, Iman; Haslegrave, Christine M; Stedmon, Alex W

    2012-01-01

    The present study was conducted to review the literature on the methods that have been considered appropriate for evaluation of the effects of gloves on different aspects of hand performance, to make recommendations for the testing and assessment of gloves, and to identify where further research is needed to improve the evaluation protocols. Eighty-five papers meeting the criteria for inclusion were reviewed. Many studies show that gloves may have negative effects on manual dexterity, tactile sensitivity, handgrip strength, muscle activity and fatigue and comfort, while further research is needed to determine glove effects on pinch strength, forearm torque strength and range of finger and wrist movements. The review also highlights several methodological issues (including consideration of both task type and duration of glove use by workers, guidance on the selection and allocation of suitable glove(s) for particular tasks/jobs, and glove design features) that need to be considered in future research. Practitioner Summary: The relevant literature on the effects of protective gloves on different aspects of hand performance was reviewed to make recommendations for the testing and assessment of gloves, and to improve evaluation protocols. The review highlights research areas and methodological issues that need to be considered in future research.

  14. Introducing GaLA: Serious Game potentials, challenges and TEL-related issues

    NARCIS (Netherlands)

    Earp, Jeffrey; Klemke, Roland

    2011-01-01

    Earp, J., & Klemke, R. (2011, 21 September). Introducing GaLA: Serious Game potentials, challenges and TEL-related issues. Presented at TEL-Think-Tank Workshop at the 6th European conference on Technology enhanced learning: towards ubiquitous learning (EC-TEL 2011), Palermo, Italy.

  15. The Rise of International Relations Programs in the Brazilian Federal Universities: Curriculum Specificities and Current Challenges

    Science.gov (United States)

    Ferreira, Marcos Alan S. V.

    2016-01-01

    The aim of this reflection is to study the new international relations (IR) programs introduced by Brazilian federal universities, looking comparatively at their curriculum specificities and current challenges. In recent years, Brazil has seen an increase of IR programs launched in several regions. Since 2003, the Ministry of Education is in the…

  16. Designing a Self-Management App for Young People With Type 1 Diabetes: Methodological Challenges, Experiences, and Recommendations.

    Science.gov (United States)

    Castensøe-Seidenfaden, Pernille; Reventlov Husted, Gitte; Teilmann, Grete; Hommel, Eva; Olsen, Birthe Susanne; Kensing, Finn

    2017-10-23

    Young people with type 1 diabetes often struggle to self-manage their disease. Mobile health (mHealth) apps show promise in supporting self-management of chronic conditions such as type 1 diabetes. Many health care providers become involved in app development. Unfortunately, limited information is available to guide their selection of appropriate methods, techniques, and tools for a participatory design (PD) project in health care. The aim of our study was to develop an mHealth app to support young people in self-managing type 1 diabetes. This paper presents our methodological recommendations based on experiences and reflections from a 2-year research study. A mixed methods design was used to identify user needs before designing the app and testing it in a randomized controlled trial. App design was based on qualitative, explorative, interventional, and experimental activities within an overall iterative PD approach. Several techniques and tools were used, including workshops, a mail panel, think-aloud tests, and a feasibility study. The final mHealth solution was "Young with Diabetes" (YWD). The iterative PD approach supported researchers and designers in understanding the needs of end users (ie, young people, parents, and health care providers) and their assessment of YWD, as well as how to improve app usability and feasibility. It is critical to include all end user groups during all phases of a PD project and to establish a multidisciplinary team to provide the wide range of expertise required to build a usable and useful mHealth app. Future research is needed to develop and evaluate more efficient PD techniques. Health care providers need guidance on what tools and techniques to choose for which subgroups of users and guidance on how to introduce an app to colleagues to successfully implement an mHealth app in health care organizations. These steps are important for anyone who wants to design an mHealth app for any illness. ©Pernille Castens

  17. Challenges, coping strategies, and recommendations related to the HIV services field in the HAART era: a systematic literature review of qualitative studies from the United States and Canada.

    Science.gov (United States)

    Kerr, Zachary Y; Miller, Katye R; Galos, Dylan; Love, Randi; Poole, Charles

    2013-02-01

    Qualitative research methods have been utilized to study the nature of work in the HIV services field. Yet current literature lacks a Highly Active Anti-Retroviral Treatment (HAART) era compendium of qualitative research studying challenges and coping strategies in the field. This study systematically reviewed challenges and coping strategies that qualitative researchers observed in the HIV services field during the HAART era, and their recommendations to organizations. Four online databases were searched for peer-reviewed research that utilized qualitative methods, were published from January 1998 to February 2012, utilized samples of individuals in the HIV services field; occurred in the U.S. or Canada, and contained information related to challenges and/or coping strategies. Abstracts were identified (n=846) and independently read and coded for inclusion by at least two of the four first authors. Identified articles (n=26) were independently read by at least two of the four first authors who recorded the study methodology, participant demographics, challenges and coping strategies, and recommendations. A number of challenges affecting those in the HIV services field were noted, particularly interpersonal and organizational issues. Coping strategies were problem- and emotion-focused. Summarized research recommendations called for increased support, capacity-building, and structural changes. Future research on challenges and coping strategies must provide up-to-date information to the HIV services field while creating, implementing, and evaluating interventions to manage current challenges and reduce the risk of burnout.

  18. Methodological challenges in evaluating health care financing equity in data-poor contexts: lessons from Ghana, South Africa and Tanzania.

    Science.gov (United States)

    Borghi, Josephine; Ataguba, John; Mtei, Gemini; Akazili, James; Meheus, Filip; Rehnberg, Clas; Di, McIntyre

    2009-01-01

    Measurement of the incidence of health financing contributions across socio-economic groups has proven valuable in informing health care financing reforms. However, there is little evidence as to how to carry out financing incidence analysis (FIA) in lower income settings. We outline some of the challenges faced when carrying out a FIA in Ghana, Tanzania and South Africa and illustrate how innovative techniques were used to overcome data weaknesses in these settings. FIA was carried out for tax, insurance and out-of-pocket (OOP) payments. The primary data sources were Living Standards Measurement Surveys (LSMS) and household surveys conducted in each of the countries; tax authorities and insurance funds also provided information. Consumption expenditure and a composite index of socioeconomic status (SES) were used to assess financing equity. Where possible conventional methods of FIA were applied. Numerous challenges were documented and solution strategies devised. LSMS are likely to underestimate financial contributions to health care by individuals. For tax incidence analysis, reported income tax payments from secondary sources were severely under-reported. Income tax payers and shareholders could not be reliably identified. The use of income or consumption expenditure to estimate income tax contributions was found to be a more reliable method of estimating income tax incidence. Assumptions regarding corporate tax incidence had a huge effect on the progressivity of corporate tax and on overall tax progressivity. LSMS consumption categories did not always coincide with tax categories for goods subject to excise tax (e.g., wine and spirits were combined, despite differing tax rates). Tobacco companies, alcohol distributors and advertising agencies were used to provide more detailed information on consumption patterns for goods subject to excise tax by income category. There was little guidance on how to allocate fuel levies associated with 'public transport' use

  19. Accessing Synthetically-Challenging Isoindole-Based Materials for Assessment in Organic Photovoltaics via Chemical and Engineering Methodologies =

    Science.gov (United States)

    Dang, Jeremy

    Isoindoles are a broad class of compounds that comprise a very small space within the domain of established photoactive materials for organic photovoltaics (OPVs). Given this scarcity, combined with the performance appeal of presently and well known isoindole-based compounds such as the phthalocyanines, it is a worthy undertaking to develop new materials in this domain. This thesis aims to bring to light the suitability of five novel, or underexplored, classes of isoindole-based materials for OPVs. These classes are the boron subphthalocyanine (BsubPc) polymers, oxygen-bridged dimers of BsubPcs (mu-oxo-(BsubPc) 2), boron subnaphthalocyanines (BsubNcs), group XIII metal complexes of 1,3-bis(2-pyridylimino)isodinoline (BPI), and the boron tribenzosubporphyrins (BsubPys). The synthesis of these materials was proven to be challenging as evident in their low isolated yields, lengthy synthetic and purification processes, and/or batch-to-batch variations. This outcome was not surprising given their undeveloped chemical nature. The photo- and electro-physical properties were characterized and shown to be desirable for all classes other than the group XIII metal complexes of BPI for OPVs. mu-Oxo-(BsubPc)2 and BsubNcs show promise in this application while BsubPc polymers and BsubPys will be subjects of future exploration. The results from the work herein aid to develop and strengthen the fundamental understanding of the structure-property relationships of isoindole derivatives. On a broader scale, the work demonstrates their versatility as functional materials for OPVs and their possible expansion to other organic electronic technologies like organic light emitting diodes and organic field effect transistors.

  20. Life history theory and breast cancer risk: methodological and theoretical challenges: Response to "Is estrogen receptor negative breast cancer risk associated with a fast life history strategy?".

    Science.gov (United States)

    Aktipis, Athena

    2016-01-01

    In a meta-analysis published by myself and co-authors, we report differences in the life history risk factors for estrogen receptor negative (ER-) and estrogen receptor positive (ER+) breast cancers. Our meta-analysis did not find the association of ER- breast cancer risk with fast life history characteristics that Hidaka and Boddy suggest in their response to our article. There are a number of possible explanations for the differences between their conclusions and the conclusions we drew from our meta-analysis, including limitations of our meta-analysis and methodological challenges in measuring and categorizing estrogen receptor status. These challenges, along with the association of ER+ breast cancer with slow life history characteristics, may make it challenging to find a clear signal of ER- breast cancer with fast life history characteristics, even if that relationship does exist. The contradictory results regarding breast cancer risk and life history characteristics illustrate a more general challenge in evolutionary medicine: often different sub-theories in evolutionary biology make contradictory predictions about disease risk. In this case, life history models predict that breast cancer risk should increase with faster life history characteristics, while the evolutionary mismatch hypothesis predicts that breast cancer risk should increase with delayed reproduction. Whether life history tradeoffs contribute to ER- breast cancer is still an open question, but current models and several lines of evidence suggest that it is a possibility. © The Author(s) 2016. Published by Oxford University Press on behalf of the Foundation for Evolution, Medicine, and Public Health.

  1. 'North-Normandy' radiological report. Methodological report related to continental and marine aquatic compartments

    International Nuclear Information System (INIS)

    Saunier, Jean-Baptiste; Leprieur, Fabrice; Pierrard, Olivier; Bailly Du Bois, Pascal; Boust, Dominique; Wyckaert, Laure; Pinel, Margaux; Sarraza, Manuel; Hamon, Nolwenn; Tetard, Xavier; Fetter, Pierre; Foucher, Eric; Lazard, Coline; Travers-Trolet, Morgane; Verin, Yves; Riviere, Camille; Villette, Frederic

    2015-01-01

    After a recall of the objectives, sampling and analysis strategy, and general methodology of radiological reports, and a general presentation of the radiological report for the 'North-Normandy' region (study framework, geographical scope, demography and activity poles), this report presents the main nuclear installations or sites which use radionuclides of natural or artificial origin: nuclear centres for power production, plants for used fuel processing, storage sites and submerged wastes, Cherbourg naval base, a company of nuclear maintenance (Somanu), industries generating wastes with a reinforced natural radioactivity, and centres of nuclear medicine. The two next chapters describe the characteristics of watersheds, the Channel and North Sea. It presents data acquired by control programmes and radio-ecological studies. The sampling strategies implemented for the continental aquatic environment, and for the coastal and offshore sea environment are described. A synthesis, a planning and perspectives are finally proposed and discussed

  2. ESTABLISHING EMPIRICAL RELATION TO PREDICT TEMPERATURE DIFFERENCE OF VORTEX TUBE USING RESPONSE SURFACE METHODOLOGY

    Directory of Open Access Journals (Sweden)

    PRABAKARAN J.

    2012-12-01

    Full Text Available Vortex tube is a device that produces cold and hot air simultaneously from the source of compressed air. In this work an attempt has been made to investigate the effect of three controllable input variables namely diameter of the orifices, diameter of the nozzles and inlet pressure over the temperature difference in the cold side as output using Response Surface Methodology (RSM. Experiments are conducted using central composite design with three factors at three levels. The influence of vital parameters and interaction among these are investigated using analysis of variance (ANOVA. The proposed mathematical model in this study has proven to fit and in line with experimental values with a 95% confidence interval. It is found that the inlet pressure and diameter of nozzle are significant factors that affect the performance of vortex tube.

  3. Pre-Ebola virus disease laboratory system and related challenges in Liberia

    Directory of Open Access Journals (Sweden)

    Stephen B. Kennedy

    2016-10-01

    Full Text Available Prior to the Ebola virus disease outbreak in Liberia, the laboratory system was duplicativefragmented and minimally coordinated. The National Reference Laboratory was conceptualisedto address the existing challenges by promoting the implementation of effective and sustainablelaboratory services in Liberia. However, in a resource-limited environment such as Liberiaprogress regarding the rebuilding of the health system can be relatively slow, while efforts tosustain the transient gains remain a key challenge for the Ministry of Health. In this paper, wedescribe the pre-Ebola virus disease laboratory system in Liberia and its prevailing efforts toaddress future emerging infectious diseases, as well as current Infectious diseases, all of whichare exacerbated by poverty. We conclude that laboratory and diagnostic services in Liberiahave encountered numerous challenges regarding its efforts to strengthen the healthcaredelivery system. These challenges include limited trained human resource capacity, inadequateinfrastructure, and a lack of coordination. As with most countries in sub-Saharan Africa, whencomparing urban and rural settings, diagnostic and clinical services are generally skewedtoward urban health facilities and private, faith-based health facilities. We recommend thatstructured policy be directed at these challenges for national institutions to develop guidelinesto improve, strengthen and sustain diagnostic and curative laboratory services to effectivelyaddress current infectious diseases and prepare for future emerging and re-emerging infectiousdiseases.

  4. Advancing Understanding on Industrial Relations in Multinational Companies: Key Research Challenges and the INTREPID Contribution

    DEFF Research Database (Denmark)

    Gunnigle, Patrick; Valeria, Pulignano; Edwards, Tony

    2015-01-01

    companies using INTREPID (Investigation of Transnationals’ Employment Practices: an International Database) data. Finally, the paper identifies some of the main industrial relations issues that remain to be addressed, in effect charting a form of research agenda for future work using the INTREPID data......This paper has three principal aims. It firstly provides some theoretical background on the key current research issues and challenges in regard to industrial relations in multinational companies. It then presents a concise review of scholarship to date on industrial relations in multinational...

  5. Study on uncertainty evaluation methodology related to hydrological parameter of regional groundwater flow analysis model

    International Nuclear Information System (INIS)

    Sakai, Ryutaro; Munakata, Masahiro; Ohoka, Masao; Kameya, Hiroshi

    2009-11-01

    In the safety assessment for a geological disposal of radioactive waste, it is important to develop a methodology for long-term estimation of regional groundwater flow from data acquisition to numerical analyses. In the uncertainties associated with estimation of regional groundwater flow, there are the one that concerns parameters and the one that concerns the hydrologeological evolution. The uncertainties of parameters include measurement errors and their heterogeneity. The authors discussed the uncertainties of hydraulic conductivity as a significant parameter for regional groundwater flow analysis. This study suggests that hydraulic conductivities of rock mass are controlled by rock characteristics such as fractures, porosity and test conditions such as hydraulic gradient, water quality, water temperature and that there exists variations more than ten times in hydraulic conductivity by difference due to test conditions such as hydraulic gradient or due to rock type variations such as rock fractures, porosity. In addition this study demonstrated that confining pressure change caused by uplift and subsidence and change of hydraulic gradient under the long-term evolution of hydrogeological environment could possibly produce variations more than ten times of magnitude in hydraulic conductivity. It was also shown that the effect of water quality change on hydraulic conductivity was not negligible and that the replacement of fresh water and saline water caused by sea level change could induce 0.6 times in current hydraulic conductivities in case of Horonobe site. (author)

  6. Lean Six Sigma in health care and the challenge of implementation of Six Sigma methodologies at a Veterans Affairs Medical Center.

    Science.gov (United States)

    Pocha, Christine

    2010-01-01

    Six Sigma and Lean Thinking are quality initiatives initially deployed in industry to improve operational efficiency leading to better quality and subsequent cost savings. The financial rationale for embarking on this quality journey is clear; applying it to today's health care remains challenging. The cost of medical care is increasing at an alarming rate; most of these cost increases are attributed to an aging population and technological advances; therefore, largely beyond control. Furthermore, health care cost increases are caused by unnecessary operational inefficiency associated with the direct medical service delivery process. This article describes the challenging journey of implementing Six Sigma methodology at a tertiary care medical center. Many lessons were learned; however, of utmost importance were team approach, "buy in" of the stakeholders, and the willingness of team members to change daily practice and to adapt new and innovative ways how health care can be delivered. Six Sigma incorporated as part of the "company's or hospital's culture" would be most desirable but the learning curve will be steep.

  7. Becoming a nurse faculty leader: facing challenges through reflecting, persevering and relating in new ways.

    Science.gov (United States)

    Horton-Deutsch, Sara; Young, Patricia K; Nelson, Kristine A

    2010-05-01

    The aim of the present study was to explore the experience of becoming a nurse faculty leader. In a recent interpretation of 23 interviews conducted with nurse faculty leaders from across the United States about their experiences of becoming a leader three themes were identified: being thrust into leadership, taking risks and facing challenges. This interpretive phenomenological study further explicates three aspects of how nurse educators faced challenges in becoming and serving as a leader. Facing challenges meant reflecting, persevering through difficulties and learning to relate to others in new ways. Exemplars of participant experiences are provided for concreteness, to assist readers in determining how findings resonate with their own experience and how they can actualize this resonance in their own leadership practice. In the present study, reflecting, persevering through difficulties and learning to relate with others in a new way was how leaders faced challenges. Leadership development opportunities that facilitate self-exploration, caring and thoughtful interactions with others and values clarification serve as the foundation for becoming a nurse faculty leader who is, in turn, able to build leadership capacity in other individuals and organizations.

  8. Physical Education in relation to the inclusive education: conceptual and methodological reflections

    Directory of Open Access Journals (Sweden)

    David António Rodrigues

    2008-05-01

    Full Text Available Inclusive Education is a main educational orientation in most countries which signed the Salamanca Declaration in 1994. By defining the Inclusive Education (IE as being “for everybody and each individual”, we aim at creating na educative model that rejects exclusion and promotes learning without barriers. Physical Education (PE is part of the inclusive curriculum. Apparently, PE seems to be more receptive to Inclusion, but in fact PE teachers seem to have more difficulties to deal with the inclusion challenges. In PE there is a “double exclusion genealogy” that implies a greater difficulty to answer to diversity. In this article some strategies to improve teacher’s education and support are suggested, in order to make the inclusive quality of PE better.

  9. Development and application of a methodology for the analysis of significant human related event trends in nuclear power plants

    International Nuclear Information System (INIS)

    Cho, H.Y.

    1981-01-01

    A methodology is developed to identify and flag significant trends related to the safety and availability of U.S. commercial nuclear power plants. The development is intended to aid in reducing likelihood of human errors. To assure that the methodology can be easily adapted to various types of classification schemes of operation data, a data bank classified by the Transient Analysis Classification and Evaluation (TRACE) scheme is selected for the methodology. The significance criteria for human-initiated events affecting the systems and for events caused by human deficiencies were developed. Clustering analysis was used to verify the learning trend in multidimensional histograms. A computer code is developed based on the K-Means algorithm and applied to find the learning period in which error rates are monotonously decreasing with plant age. The Freeman-Tukey (F-T) deviates are used to select generic problems identified by a large positive value (here approximately over 2.0) for the deviate. The identified generic problems are: decision errors which are highly associated with reactor startup operations in the learning period of PWR plants (PWRs), response errors which are highly associated with Secondary Non-Nuclear Systems (SNS) in PWRs, and significant errors affecting systems and which are caused by response action are highly associated with startup reactor mode in BWRS

  10. Problems and challenges in relation to the treatment of patients with multimorbidity

    DEFF Research Database (Denmark)

    Søndergaard, Elisabeth; Willadsen, Tora Grauers; Guassora, Ann Dorrit

    2015-01-01

    Objective. To explore views and attitudes among general practitioners (GPs) and researchers in the field of general practice towards problems and challenges related to treatment of patients with multimorbidity. Setting. A workshop entitled Patients with multimorbidity in general practice held...... during the Nordic Congress of General Practice in Tampere, Finland, 2013. Subjects. A total of 180 GPs and researchers. Design. Data for this summary report originate from audio-recorded, transcribed verbatim plenary discussions as well as 76 short questionnaires answered by attendees during the workshop...... of multimorbid patients underlined the GPs’ impression of a fragmented health care system; (iii) GPs found it challenging to establish a good dialogue and prioritize problems with patients within the timeframe of a normal consultation; (iv) the future role of the GP was discussed in relation to diminishing...

  11. An Inexpensive, Stable, and Accurate Relative Humidity Measurement Method for Challenging Environments.

    Science.gov (United States)

    Zhang, Wei; Ma, Hong; Yang, Simon X

    2016-03-18

    In this research, an improved psychrometer is developed to solve practical issues arising in the relative humidity measurement of challenging drying environments for meat manufacturing in agricultural and agri-food industries. The design in this research focused on the structure of the improved psychrometer, signal conversion, and calculation methods. The experimental results showed the effect of varying psychrometer structure on relative humidity measurement accuracy. An industrial application to dry-cured meat products demonstrated the effective performance of the improved psychrometer being used as a relative humidity measurement sensor in meat-drying rooms. In a drying environment for meat manufacturing, the achieved measurement accuracy for relative humidity using the improved psychrometer was ±0.6%. The system test results showed that the improved psychrometer can provide reliable and long-term stable relative humidity measurements with high accuracy in the drying system of meat products.

  12. A Methodological Study of Order Effects in Reporting Relational Aggression Experiences.

    Science.gov (United States)

    Serico, Jennifer M; NeMoyer, Amanda; Goldstein, Naomi E S; Houck, Mark; Leff, Stephen S

    2018-03-01

    Unlike the overt nature of physical aggression, which lends itself to simpler and more direct methods of investigation, the often-masked nature of relational aggression has led to difficulties and debate regarding the most effective tools of study. Given concerns with the accuracy of third-party relational aggression reports, especially as individuals age, self-report measures may be particularly useful when assessing experiences with relational aggression. However, it is important to recognize validity concerns-in particular, the potential effects of item order presentation-associated with self-report of relational aggression perpetration and victimization. To investigate this issue, surveys were administered and completed by 179 young adults randomly assigned to one of four survey conditions reflecting manipulation of item order. Survey conditions included presentation of (a) perpetration items only, (b) victimization items only, (c) perpetration items followed by victimization items, and (d) victimization items followed by perpetration items. Results revealed that participants reported perpetrating relational aggression significantly more often when asked only about perpetration or when asked about perpetration before victimization, compared with participants who were asked about victimization before perpetration. Item order manipulation did not result in significant differences in self-reported victimization experiences. Results of this study indicate a need for greater consideration of item order when conducting research using self-report data and the importance of additional investigation into which form of item presentation elicits the most accurate self-report information.

  13. Validation of a Crowdsourcing Methodology for Developing a Knowledge Base of Related Problem-Medication Pairs.

    Science.gov (United States)

    McCoy, A B; Wright, A; Krousel-Wood, M; Thomas, E J; McCoy, J A; Sittig, D F

    2015-01-01

    Clinical knowledge bases of problem-medication pairs are necessary for many informatics solutions that improve patient safety, such as clinical summarization. However, developing these knowledge bases can be challenging. We sought to validate a previously developed crowdsourcing approach for generating a knowledge base of problem-medication pairs in a large, non-university health care system with a widely used, commercially available electronic health record. We first retrieved medications and problems entered in the electronic health record by clinicians during routine care during a six month study period. Following the previously published approach, we calculated the link frequency and link ratio for each pair then identified a threshold cutoff for estimated problem-medication pair appropriateness through clinician review; problem-medication pairs meeting the threshold were included in the resulting knowledge base. We selected 50 medications and their gold standard indications to compare the resulting knowledge base to the pilot knowledge base developed previously and determine its recall and precision. The resulting knowledge base contained 26,912 pairs, had a recall of 62.3% and a precision of 87.5%, and outperformed the pilot knowledge base containing 11,167 pairs from the previous study, which had a recall of 46.9% and a precision of 83.3%. We validated the crowdsourcing approach for generating a knowledge base of problem-medication pairs in a large non-university health care system with a widely used, commercially available electronic health record, indicating that the approach may be generalizable across healthcare settings and clinical systems. Further research is necessary to better evaluate the knowledge, to compare crowdsourcing with other approaches, and to evaluate if incorporating the knowledge into electronic health records improves patient outcomes.

  14. Validation of a Crowdsourcing Methodology for Developing a Knowledge Base of Related Problem-Medication Pairs

    Science.gov (United States)

    Wright, A.; Krousel-Wood, M.; Thomas, E. J.; McCoy, J. A.; Sittig, D. F.

    2015-01-01

    Summary Background Clinical knowledge bases of problem-medication pairs are necessary for many informatics solutions that improve patient safety, such as clinical summarization. However, developing these knowledge bases can be challenging. Objective We sought to validate a previously developed crowdsourcing approach for generating a knowledge base of problem-medication pairs in a large, non-university health care system with a widely used, commercially available electronic health record. Methods We first retrieved medications and problems entered in the electronic health record by clinicians during routine care during a six month study period. Following the previously published approach, we calculated the link frequency and link ratio for each pair then identified a threshold cutoff for estimated problem-medication pair appropriateness through clinician review; problem-medication pairs meeting the threshold were included in the resulting knowledge base. We selected 50 medications and their gold standard indications to compare the resulting knowledge base to the pilot knowledge base developed previously and determine its recall and precision. Results The resulting knowledge base contained 26,912 pairs, had a recall of 62.3% and a precision of 87.5%, and outperformed the pilot knowledge base containing 11,167 pairs from the previous study, which had a recall of 46.9% and a precision of 83.3%. Conclusions We validated the crowdsourcing approach for generating a knowledge base of problem-medication pairs in a large non-university health care system with a widely used, commercially available electronic health record, indicating that the approach may be generalizable across healthcare settings and clinical systems. Further research is necessary to better evaluate the knowledge, to compare crowdsourcing with other approaches, and to evaluate if incorporating the knowledge into electronic health records improves patient outcomes. PMID:26171079

  15. Methodological challenges in collecting social and behavioural data regarding the HIV epidemic among gay and other men who have sex with men in Australia.

    Directory of Open Access Journals (Sweden)

    Iryna B Zablotska

    Full Text Available BACKGROUND: Behavioural surveillance and research among gay and other men who have sex with men (GMSM commonly relies on non-random recruitment approaches. Methodological challenges limit their ability to accurately represent the population of adult GMSM. We compared the social and behavioural profiles of GMSM recruited via venue-based, online, and respondent-driven sampling (RDS and discussed their utility for behavioural surveillance. METHODS: Data from four studies were selected to reflect each recruitment method. We compared demographic characteristics and the prevalence of key indicators including sexual and HIV testing practices obtained from samples recruited through different methods, and population estimates from respondent-driven sampling partition analysis. RESULTS: Overall, the socio-demographic profile of GMSM was similar across samples, with some differences observed in age and sexual identification. Men recruited through time-location sampling appeared more connected to the gay community, reported a greater number of sexual partners, but engaged in less unprotected anal intercourse with regular (UAIR or casual partners (UAIC. The RDS sample overestimated the proportion of HIV-positive men and appeared to recruit men with an overall higher number of sexual partners. A single-website survey recruited a sample with characteristics which differed considerably from the population estimates with regards to age, ethnically diversity and behaviour. Data acquired through time-location sampling underestimated the rates of UAIR and UAIC, while RDS and online sampling both generated samples that underestimated UAIR. Simulated composite samples combining recruits from time-location and multi-website online sampling may produce characteristics more consistent with the population estimates, particularly with regards to sexual practices. CONCLUSION: Respondent-driven sampling produced the sample that was most consistent to population estimates

  16. Methodological challenges in collecting social and behavioural data regarding the HIV epidemic among gay and other men who have sex with men in Australia.

    Science.gov (United States)

    Zablotska, Iryna B; Frankland, Andrew; Holt, Martin; de Wit, John; Brown, Graham; Maycock, Bruce; Fairley, Christopher; Prestage, Garrett

    2014-01-01

    Behavioural surveillance and research among gay and other men who have sex with men (GMSM) commonly relies on non-random recruitment approaches. Methodological challenges limit their ability to accurately represent the population of adult GMSM. We compared the social and behavioural profiles of GMSM recruited via venue-based, online, and respondent-driven sampling (RDS) and discussed their utility for behavioural surveillance. Data from four studies were selected to reflect each recruitment method. We compared demographic characteristics and the prevalence of key indicators including sexual and HIV testing practices obtained from samples recruited through different methods, and population estimates from respondent-driven sampling partition analysis. Overall, the socio-demographic profile of GMSM was similar across samples, with some differences observed in age and sexual identification. Men recruited through time-location sampling appeared more connected to the gay community, reported a greater number of sexual partners, but engaged in less unprotected anal intercourse with regular (UAIR) or casual partners (UAIC). The RDS sample overestimated the proportion of HIV-positive men and appeared to recruit men with an overall higher number of sexual partners. A single-website survey recruited a sample with characteristics which differed considerably from the population estimates with regards to age, ethnically diversity and behaviour. Data acquired through time-location sampling underestimated the rates of UAIR and UAIC, while RDS and online sampling both generated samples that underestimated UAIR. Simulated composite samples combining recruits from time-location and multi-website online sampling may produce characteristics more consistent with the population estimates, particularly with regards to sexual practices. Respondent-driven sampling produced the sample that was most consistent to population estimates, but this methodology is complex and logistically demanding

  17. Current methodological questions of studying social-political relations of global society

    Directory of Open Access Journals (Sweden)

    Marković Danilo Ž.

    2010-01-01

    planetary and cosmic consequences. Dignity of man and his work, regarding the global character of economic life, whose bearers are multinational corporations, and global character of job market, regarding preservation of dignity of work as presumption of preservation of dignity of man. However, the question is if the contemporary level of science development allows this, first of all social sciences and especially sociology (which is generally determined as the most general science on society and its totality. In fact, the question is if the theoretical-cognitive apparatus of sociology allows studying of the complex structure and category of contemporary society and their dynamics of changes that are not accompanied by development of suitable idea-terminological apparatus. As Sorokin points out, many theories have appeared in sociology since Auguste Comte that had their boom, and then they were contested and finally disappeared. Considering the problems of sociological theories, it should be born in mind that a 'universal' sociological theory cannot exist because few theoretical-methodological attitudes are not enough to interpret accelerated complexity of social development dynamics, and the society is changing very fast. However, it is possible to specify the theory parameters in the context for valid interpretation of development tendencies of self-development of society. Tendency of postmodernism to make the society in its construction and dynamics by its subject of study, especially by establishing postmodern sociological terminology, indicates tendency that postmodernism paradigm questions the referred determinacy of sociology itself, which has been developed and survived as science on classical terminology. A danger exists that paradigm arisen from tendency to modernize cognitional apparatus of sociology (the terms questions existence of the science itself within which it has originated, i.e. sociology. Therefore, postmodern sociological paradigm should be also

  18. Integrated methodology for production related risk management of vehicle electronics (IMPROVE)

    OpenAIRE

    Geis, Stefan Rafael

    2006-01-01

    This scientific work is designated to provide an innovative and integrated conceptional approach to improve the assembly quality of automotive electronics. This is achieved by the reduction and elimination of production related risks of automotive electronics and the implementation of a sustainable solution process. The focus is the development and implementation of an integrated technical risk management approach for automotive electronics throughout the vehicle life cycle and the vehicle pr...

  19. Methodology to estimate the relative pressure field from noisy experimental velocity data

    International Nuclear Information System (INIS)

    Bolin, C D; Raguin, L G

    2008-01-01

    The determination of intravascular pressure fields is important to the characterization of cardiovascular pathology. We present a two-stage method that solves the inverse problem of estimating the relative pressure field from noisy velocity fields measured by phase contrast magnetic resonance imaging (PC-MRI) on an irregular domain with limited spatial resolution, and includes a filter for the experimental noise. For the pressure calculation, the Poisson pressure equation is solved by embedding the irregular flow domain into a regular domain. To lessen the propagation of the noise inherent to the velocity measurements, three filters - a median filter and two physics-based filters - are evaluated using a 2-D Couette flow. The two physics-based filters outperform the median filter for the estimation of the relative pressure field for realistic signal-to-noise ratios (SNR = 5 to 30). The most accurate pressure field results from a filter that applies in a least-squares sense three constraints simultaneously: consistency between measured and filtered velocity fields, divergence-free and additional smoothness conditions. This filter leads to a 5-fold gain in accuracy for the estimated relative pressure field compared to without noise filtering, in conditions consistent with PC-MRI of the carotid artery: SNR = 5, 20 x 20 discretized flow domain (25 X 25 computational domain).

  20. Towards the Development of a Methodology for the Cyber Security Analysis of Safety Related Nuclear Digital I and C Systems

    International Nuclear Information System (INIS)

    Khand, Parvaiz Ahmed; Seong, Poong Hyun

    2007-01-01

    In nuclear power plants the redundant safety related systems are designed to take automatic action to prevent and mitigate accident conditions if the operators and the non-safety systems fail to maintain the plant within normal operating conditions. In case of an event, the failure of these systems has catastrophic consequences. The tendency in the industry over the past 10 years has been to use of commercial of the shelf (COTS) technologies in these systems. COTS software was written with attention to function and performance rather than security. COTS hardware usually designed to fail safe, but security vulnerabilities could be exploited by an attacker to disable the fail safe mechanisms. Moreover, the use of open protocols and operating systems in these technologies make the plants to become vulnerable to a host of cyber attacks. An effective security analysis process is required during all life cycle phases of these systems in order to ensure the security from cyber attacks. We are developing a methodology for the cyber security analysis of safety related nuclear digital I and C Systems. This methodology will cover all phases of development, operation and maintenance processes of software life cycle. In this paper, we will present a security analysis process for the concept stage of software development life cycle

  1. Economic competitiveness gap related to the application of the GAEC standards of cross-compliance on farms: evaluation methodology

    Directory of Open Access Journals (Sweden)

    Marco Fedrizzi

    2015-12-01

    Full Text Available This paper describes the methods used in the monitoring carried out in the farms of the MO.NA.CO. project, to calculate the economic competitiveness gap faced by agricultural holdings that accede to the commitments imposed by the standards included in the project. The monitoring works were performed in agricultural holdings in relation to the particular reference condition of each standard. The processing of the information acquired allowed us to define the working times of each cultivation operation by means of the indications in the recommendations of the Associazione Italiana di Genio Rurale - Italian Rural Engineering Association, that considers the official methodology of the International Commission of the Organisation Scientifique du Travail en Agriculture (C.I.O.S.T.A.. The overall costs and revenues in case of compliance or non-compliance with the commitments of the standard were calculated by using Biondi’s methodology and other norms that indicate the technical and economic coefficients to be used in the calculations (EP 496.2 and D 497.4 ASAE standards. With the data related to the unit cost of ploughing a model Partial Least Squares (PLS has been achieved and validated, and it makes possible to predict the unit cost of this agricultural operation. Finally, the values of the variation of the economic competitiveness gap are reported for each standard.

  2. Applications of High Throughput (Combinatorial) Methodologies to Electronic, Magnetic, Optical, and Energy-Related Materials

    Science.gov (United States)

    2013-06-17

    ray beams in transmission geome- try.48 Using 100 nm thick films in the Ce2O3–Al2O3–HfO2 system, they were able to obtain texture , epitaxial relation...is the identification of lead-free, high piezoelectric coefficient replacements for the commonly used compound Pb(Zr,Ti)O3 ( PZT ). Ferroelectric...Fig. 24 shows the variation in the electric-field induced transition in a bulk ceramic composition spread, where a subtle substitution effect of a

  3. Critical review of methodology and application of risk ranking for prioritisation of food and feed related issues, on the basis of the size of anticipated health impact

    NARCIS (Netherlands)

    Fels-Klerx, van der H.J.; Asselt, van E.D.; Raley, M.; Poulsen, M.; Korsgaard, H.; Bredsdorff, L.; Nauta, M.; Flari, V.; Agostino, D' M.; Coles, D.G.; Frewer, L.J.

    2015-01-01

    This study aimed to critically review methodologies for ranking of risks related to feed/food safety and nutritional hazards, on the basis of their anticipated human health impact. An extensive systematic literature review was performed to identify and characterize the available methodologies for

  4. The KULTURisk Regional Risk Assessment methodology for water-related natural hazards - Part 1: Physical-environmental assessment

    Science.gov (United States)

    Ronco, P.; Gallina, V.; Torresan, S.; Zabeo, A.; Semenzin, E.; Critto, A.; Marcomini, A.

    2014-07-01

    In recent years, the frequency of catastrophes induced by natural hazard has increased and flood events in particular have been recognized as one of the most threatening water-related disasters. Severe floods have occurred in Europe over the last decade causing loss of life, displacement of people and heavy economic losses. Flood disasters are growing as a consequence of many factors, both climatic and non-climatic. Indeed, the current increase of water-related disasters can be mainly attributed to the increase of exposure (increase elements potentially at risk in floodplains area) and vulnerability (i.e. economic, social, geographic, cultural, and physical/environmental characteristics of the exposure). Besides these factors, the strong effect of climate change is projected to radically modify the usual pattern of the hydrological cycle by intensifying the frequency and severity of flood events both at local, regional and global scale. Within this context, it becomes urgent and dramatically relevant the need of promoting and developing effective and pro-active strategies, tools and actions which allow to assess and (possibly) to reduce the flood risks that threats different relevant receptors. Several methodologies to assess the risk posed by water-related natural hazards have been proposed so far, but very few of them can be adopted to implement the last European Flood Directive (FD). The present study is intended to introduce and present a state-of-the-art Regional Risk Assessment (RRA) methodology to evaluate the benefits of risk prevention in terms of reduced environmental risks due to floods. The methodology, developed within the recently phased out FP7-KULTURisk Project (Knowledge-based approach to develop a cULTUre of Risk prevention - KR) is flexible and can be adapted to different case studies (i.e. large rivers, alpine/mountain catchments, urban areas and coastal areas) and spatial scales (i.e. from the large river to the urban scale). The FD compliant

  5. Exploiting Semantic Search Methodologies to Analyse Fast Nuclear Reactor Nuclear Related Information

    International Nuclear Information System (INIS)

    Costantini, L.

    2016-01-01

    Full text: This paper describes an experiment to evaluate the outcomes of using the semantic search engine together with the entity extraction approach and the visualisation tools in large set of nuclear data related to fast nuclear reactors (FNR) documents originated from INIS database and the IAEA web publication. The INIS database has been used because is the larger collection of nuclear related data and a sub-set of it can be utilised to verify the efficiency and the effectiveness of this approach. In a nutshell, the goal of the study was to: 1) find and monitor documents dealing with FNR; 2) building knowledge base (KB) according to the FNR nuclear components and populate the KB with relevant documents; 3) communicate the conclusion of the analysis by utilising visualisation tools. The semantic search engine used in the case study has the capability to perform what is called evidential reasoning: accruing, weighing and evaluating the evidence to determinate a mathematical score for each article that measures its relevance to the subject of interest. This approach provides a means to differentiate between articles that closely meet the search criteria versus those less relevant articles. Tovek software platform was chosen for this case study. (author

  6. Molecular genetic models related to schizophrenia and psychotic illness: heuristics and challenges.

    Science.gov (United States)

    O'Tuathaigh, Colm M P; Desbonnet, Lieve; Moran, Paula M; Kirby, Brian P; Waddington, John L

    2011-01-01

    Schizophrenia is a heritable disorder that may involve several common genes of small effect and/or rare copy number variation, with phenotypic heterogeneity across patients. Furthermore, any boundaries vis-à-vis other psychotic disorders are far from clear. Consequently, identification of informative animal models for this disorder, which typically relate to pharmacological and putative pathophysiological processes of uncertain validity, faces considerable challenges. In juxtaposition, the majority of mutant models for schizophrenia relate to the functional roles of a diverse set of genes associated with risk for the disorder or with such putative pathophysiological processes. This chapter seeks to outline the evidence from phenotypic studies in mutant models related to schizophrenia. These have commonly assessed the degree to which mutation of a schizophrenia-related gene is associated with the expression of several aspects of the schizophrenia phenotype or more circumscribed, schizophrenia-related endophenotypes; typically, they place specific emphasis on positive and negative symptoms and cognitive deficits, and extend to structural and other pathological features. We first consider the primary technological approaches to the generation of such mutants, to include their relative merits and demerits, and then highlight the diverse phenotypic approaches that have been developed for their assessment. The chapter then considers the application of mutant phenotypes to study pathobiological and pharmacological mechanisms thought to be relevant for schizophrenia, particularly in terms of dopaminergic and glutamatergic dysfunction, and to an increasing range of candidate susceptibility genes and copy number variants. Finally, we discuss several pertinent issues and challenges within the field which relate to both phenotypic evaluation and a growing appreciation of the functional genomics of schizophrenia and the involvement of gene × environment interactions.

  7. METHODOLOGICAL PECULIARITIES OF TEACHING FUTURE ECONOMISTS TO READ ENGLISH TEXTS RELATED TO PROFESSIONAL AREA

    Directory of Open Access Journals (Sweden)

    Ліліана Білогорка

    2015-09-01

    Full Text Available The role of reading competence in the structure of English professionally oriented communicative competence has been analysed; types of economics texts which should be used in teaching future economists – scientific economics texts, texts of professional economics activity, educational economics texts, texts of non-professional economics activity have been defined; the necessity of using not only authentic, but also semi-authentic and adapted texts in teaching future economists to read English texts related to professional area has been grounded; bachelor’s level requirements for students’ knowledge and skills in skimming, scanning reading and reading for detail have been defined; direct (cognitive and compensatory and indirect (metacognitive, affective and social learning strategies to enhance the quality of text reading have been specified in the article.

  8. Methodological considerations related to nurse researchers using their own experience of a phenomenon within phenomenology.

    Science.gov (United States)

    Johnston, Colleen M; Wallis, Marianne; Oprescu, Florin I; Gray, Marion

    2017-03-01

    This paper summarizes phenomenology and discusses how nurses can use their own experiences as data and maintain rigour within the method. It explores how data from researchers experiencing the phenomenon of interest could be used to explicate assumptions and pre-understandings and may also be used as data. While the ethnographic concept of insider research has gained popularity, the notion of researcher as participant in phenomenology is relatively new. The lived experience of a phenomenon is unique to each person and utilization of the nurse researcher's experiences of the phenomenon should be considered for inclusion as data. Discussion paper. Articles from 2001 - 2015 in the CINAHL and PubMed databases were identified using keywords such as 'insider research', 'phenomenology', 'bracketing' and 'qualitative research'. In addition, reference lists from articles used were examined to identify additional literature. Phenomenology is a valuable research method. Usability, credibility, trustworthiness and auditability of data collected must be considered to ensure rigour and maintain orientation to the phenomenon under investigation. Nurse researchers may be interviewed as participants if these four principles are considered and methods used are made explicit. Utilizing appropriate research methods are as important as getting clinical practice correct to advance knowledge and benefit those under our care. We recommend using the researchers' experience as a data source to gain a complete picture of the phenomenon under investigation. Using the approach proposed here, nurses can ensure they are incorporating all data sources available while maintaining research rigour. © 2016 John Wiley & Sons Ltd.

  9. Evaluation of the performance of diagnosis-related groups and similar casemix systems: methodological issues.

    Science.gov (United States)

    Palmer, G; Reid, B

    2001-05-01

    With the increasing recognition and application of casemix for managing and financing healthcare resources, the evaluation of alternative versions of systems such as diagnosis-related groups (DRGs) has been afforded high priority by governments and researchers in many countries. Outside the United States, an important issue has been the perceived need to produce local versions, and to establish whether or not these perform more effectively than the US-based classifications. A discussion of casemix evaluation criteria highlights the large number of measures that may be used, the rationale and assumptions underlying each measure, and the problems in interpreting the results. A review of recent evaluation studies from a number of countries indicates that considerable emphasis has been placed on the predictive validity criterion, as measured by the R2 statistic. However, the interpretation of the findings has been affected greatly by the methods used, especially the treatment and definition of outlier cases. Furthermore, the extent to which other evaluation criteria have been addressed has varied widely. In the absence of minimum evaluation standards, it is not possible to draw clear-cut conclusions about the superiority of one version of a casemix system over another, the need for a local adaptation, or the further development of an existing version. Without the evidence provided by properly designed studies, policy-makers and managers may place undue reliance on subjective judgments and the views of the most influential, but not necessarily best informed, healthcare interest groups.

  10. European methodology of analysis vertical restraints under rule of reason in context of cooperative relation specific investments

    Directory of Open Access Journals (Sweden)

    Agamirova Maria, Е.

    2015-06-01

    Full Text Available The problem of underinvestment in specific assets is a key issue in new institutional economics, especially in case of cooperative relation specific investments. It can be solved due to vertical restraints, as an alternative way of vertical integration to transfer control to partner, who makes relation specific investments. The type of relationspecific investments called «cooperative» investments (or cross investments was nearly absent in economic analysis up to the very end of the twentieth century despite of the fact that such investments are widespread. It led to the absence of analysis relation specific investments in official regulation documents. At the same time, different types of relation specific investments can be characterized by different degree of riskiness and need special regulations of vertical agreements. In the paper author makes an attempt to analyze the European methodology of assessment vertical restraints under rule of reason focusing on the type of relation specific investments. It makes possible to improve analysis of vertical restraint in Russian antitrust.

  11. Feasibility Study on the Satellite Rainfall Data for Prediction of Sediment- Related Disaster by the Japanese Prediction Methodology

    Science.gov (United States)

    Shimizu, Y.; Ishizuka, T.; Osanai, N.; Okazumi, T.

    2014-12-01

    In this study, the sediment-related disaster prediction method which based ground gauged rainfall-data, currently practiced in Japan was coupled with satellite rainfall data and applied to domestic large-scale sediment-related disasters. The study confirmed the feasibility of this integrated method. In Asia, large-scale sediment-related disasters which can sweep away an entire settlement occur frequently. Leyte Island suffered from a huge landslide in 2004, and Typhoon Molakot in 2009 caused huge landslides in Taiwan. In the event of these sediment-related disasters, immediate responses by central and local governments are crucial in crisis management. In general, there are not enough rainfall gauge stations in developing countries. Therefore national and local governments have little information to determine the risk level of water induced disasters in their service areas. In the Japanese methodology, a criterion is set by combining two indices: the short-term rainfall index and long-term rainfall index. The short-term rainfall index is defined as the 60-minute total rainfall; the long-term rainfall index as the soil-water index, which is an estimation of the retention status of fallen rainfall in soil. In July 2009, a high-density sediment related disaster, or a debris flow, occurred in Hofu City of Yamaguchi Prefecture, in the western region of Japan. This event was calculated by the Japanese standard methodology, and then analyzed for its feasibility. Hourly satellite based rainfall has underestimates compared with ground based rainfall data. Long-term index correlates with each other. Therefore, this study confirmed that it is possible to deliver information on the risk level of sediment-related disasters such as shallow landslides and debris flows. The prediction method tested in this study is expected to assist for timely emergency responses to rainfall-induced natural disasters in sparsely gauged areas. As the Global Precipitation Measurement (GPM) Plan

  12. Psychosocial determinants of parental human papillomavirus (HPV) vaccine decision-making for sons: Methodological challenges and initial results of a pan-Canadian longitudinal study.

    Science.gov (United States)

    Perez, Samara; Tatar, Ovidiu; Shapiro, Gilla K; Dubé, Eve; Ogilvie, Gina; Guichon, Juliet; Gilca, Vladimir; Rosberger, Zeev

    2016-12-05

    interventions to increase HPV knowledge and increase HPV vaccine uptake. Intentions to vaccinate or planning to speak to one's HCP did not translate into action for most parents over the 9-month follow up; this finding is critical to consider to inform implementation strategies. Methodological challenges are described and suggestions for future research are offered.

  13. Psychosocial determinants of parental human papillomavirus (HPV vaccine decision-making for sons: Methodological challenges and initial results of a pan-Canadian longitudinal study

    Directory of Open Access Journals (Sweden)

    Samara Perez

    2016-12-01

    preferences were identified and can be used in interventions to increase HPV knowledge and increase HPV vaccine uptake. Intentions to vaccinate or planning to speak to one’s HCP did not translate into action for most parents over the 9-month follow up; this finding is critical to consider to inform implementation strategies. Methodological challenges are described and suggestions for future research are offered.

  14. Safety-Related Contractor Activities at Nuclear Power Plants. New Challenges for Regulatory Oversight

    Energy Technology Data Exchange (ETDEWEB)

    Chockie, Alan [Chockie Group International, Inc., Seattle, WA (United States)

    2005-09-15

    The use of contractors has been an integral and important part of the design, construction, operation, and maintenance of nuclear power plants. To ensure the safe and efficient completion of contracted tasks, each nuclear plant licensee has developed and refined formal contract management processes to meet their specific needs and plant requirements. Although these contract management processes have proven to be effective tools for the procurement of support and components tailored to the needs of nuclear power plants, contractor-related incidents and accidents have revealed some serious weaknesses with the implementation of these processes. Identifying and addressing implementation problems are becoming more complicated due to organizational and personnel changes affecting the nuclear power industry. The ability of regulators and licensees to effectively monitor and manage the safety-related performance of contractors will likely be affected by forthcoming organization and personnel changes due to: the aging of the workforce; the decline of the nuclear industry; and the deregulation of nuclear power. The objective of this report is to provide a review of current and potential future challenges facing safety-related contractor activities at nuclear power plants. The purpose is to assist SKI in establishing a strategy for the proactive oversight of contractor safety-related activities at Swedish nuclear power plants and facilities. The nature and role of contractors at nuclear plants is briefly reviewed in the first section of the report. The second section describes the essential elements of the contract management process. Although organizations have had decades of experience with the a contract management process, there remain a number of common implantation weaknesses that have lead to serious contractor-related incidents and accidents. These implementation weaknesses are summarized in the third section. The fourth section of the report highlights the

  15. Safety-Related Contractor Activities at Nuclear Power Plants. New Challenges for Regulatory Oversight

    International Nuclear Information System (INIS)

    Chockie, Alan

    2005-09-01

    The use of contractors has been an integral and important part of the design, construction, operation, and maintenance of nuclear power plants. To ensure the safe and efficient completion of contracted tasks, each nuclear plant licensee has developed and refined formal contract management processes to meet their specific needs and plant requirements. Although these contract management processes have proven to be effective tools for the procurement of support and components tailored to the needs of nuclear power plants, contractor-related incidents and accidents have revealed some serious weaknesses with the implementation of these processes. Identifying and addressing implementation problems are becoming more complicated due to organizational and personnel changes affecting the nuclear power industry. The ability of regulators and licensees to effectively monitor and manage the safety-related performance of contractors will likely be affected by forthcoming organization and personnel changes due to: the aging of the workforce; the decline of the nuclear industry; and the deregulation of nuclear power. The objective of this report is to provide a review of current and potential future challenges facing safety-related contractor activities at nuclear power plants. The purpose is to assist SKI in establishing a strategy for the proactive oversight of contractor safety-related activities at Swedish nuclear power plants and facilities. The nature and role of contractors at nuclear plants is briefly reviewed in the first section of the report. The second section describes the essential elements of the contract management process. Although organizations have had decades of experience with the a contract management process, there remain a number of common implantation weaknesses that have lead to serious contractor-related incidents and accidents. These implementation weaknesses are summarized in the third section. The fourth section of the report highlights the

  16. Aviation Trends Related to Atmospheric Environment Safety Technologies Project Technical Challenges

    Science.gov (United States)

    Reveley, Mary S.; Withrow, Colleen A.; Barr, Lawrence C.; Evans, Joni K.; Leone, Karen M.; Jones, Sharon M.

    2014-01-01

    Current and future aviation safety trends related to the National Aeronautics and Space Administration's Atmospheric Environment Safety Technologies Project's three technical challenges (engine icing characterization and simulation capability; airframe icing simulation and engineering tool capability; and atmospheric hazard sensing and mitigation technology capability) were assessed by examining the National Transportation Safety Board (NTSB) accident database (1989 to 2008), incidents from the Federal Aviation Administration (FAA) accident/incident database (1989 to 2006), and literature from various industry and government sources. The accident and incident data were examined for events involving fixed-wing airplanes operating under Federal Aviation Regulation (FAR) Parts 121, 135, and 91 for atmospheric conditions related to airframe icing, ice-crystal engine icing, turbulence, clear air turbulence, wake vortex, lightning, and low visibility (fog, low ceiling, clouds, precipitation, and low lighting). Five future aviation safety risk areas associated with the three AEST technical challenges were identified after an exhaustive survey of a variety of sources and include: approach and landing accident reduction, icing/ice detection, loss of control in flight, super density operations, and runway safety.

  17. A novel approach to challenging OCD related beliefs using a mobile-app: An exploratory study.

    Science.gov (United States)

    Roncero, María; Belloch, Amparo; Doron, Guy

    2018-06-01

    According to cognitive models, obsessive compulsive symptoms result from catastrophic misinterpretations of commonly occurring intrusive experiences and the use of counterproductive strategies to manage them. Obsessive Compulsive Disorder (OCD) related beliefs such as inflated responsibility, importance of thoughts and perfectionism increases the likelihood of such misinterpretations. Consistent with a growing body of literature supporting the usefulness of mobile delivered technologies in fostering cognitive behavior change, the present study assessed the effectiveness of a novel cognitive training exercise designed to challenge OCD-related beliefs. This mobile app training exercise consists of users having to pull statements challenging OCD beliefs towards themselves (downwards) and to throw away (push upwards) contra-productive self-statements. 36 third-year BA students started the trial. Twenty completed pre and post measures of OCD-beliefs, mood and OCD symptoms including relationship-obsessions. Participants were instructed to complete 3 min of daily training for a period of 15 days. No significant differences were found between completers and non-completers on demographic and most symptom related measures at Time 1. Repeated-measures MANOVA of the 20 completers showed a significant reduction on all OCD symptoms measures and on OCD-beliefs. No significant reduction was found in depression symptoms. Regression analysis showed change in levels of OCD-beliefs was associated with reduction in OCD symptoms at Time 2 over and above OCD symptoms at Time 1. The study is an open trial with non-clinical participants. This mobile delivered training exercise may be useful for the reduction and relapse prevention of OCD-related beliefs and symptoms. Copyright © 2018 Elsevier Ltd. All rights reserved.

  18. Exploring the challenge of health research priority setting in partnership: reflections on the methodology used by the James Lind Alliance Pressure Ulcer Priority Setting Partnership.

    Science.gov (United States)

    Madden, Mary; Morley, Richard

    2016-01-01

    treatment. There is no formal evaluation yet to examine the different approaches used by individual PSPs and the impact these methods have on the quality of the partnership and subsequent outputs. There is no gold standard method for health research topic identification and priority setting and reporting on public involvement in this area is predominantly descriptive rather than evaluative. The JLA Pressure Ulcer PSP (JLAPUP) was developed and worked between 2009 and 2013 to identify and prioritise the top 10 'uncertainties' , or 'unanswered questions', about the effects of pressure ulcer interventions. JLAPUP identified a mismatch between the nature and quality of RCTs in pressure ulcer prevention and treatment and the kind of research evidence desired by patients or service users, carers and health professionals. Results and methods have been reported fully elsewhere. The consultative and deliberative methods used to establish health research priorities in PSPs are fundamentally interpretive. PSPs are therefore an arena in which 'hard' evidence-informed ideals meet 'soft' participatory practices. This article provides an account of the challenges faced in one particular PSP. We explain the rationale for the approaches taken, difficulties faced and the limitations at each stage, because these aspects are particularly under-reported. The JLAPUP case is used to identify possible areas for evaluation and reporting across PSPs. Engaging people with very different health and life experiences in the complexities of health science based discussions of uncertainty is challenging. This is particularly the case when engaging groups routinely excluded from participating in health research, for example, older people with multiple comorbidities. The JLA principles of transparency, inclusivity and avoiding waste in research require paying close critical attention to PSP methodology, including full evaluation and reporting of PSP processes and outcomes. Assessing the impact of PSPs is

  19. Ethical challenges related to elder care. High level decision-makers' experiences

    Directory of Open Access Journals (Sweden)

    Kihlgren Mona

    2007-04-01

    Full Text Available Abstract Background Few empirical studies have been found that explore ethical challenges among persons in high public positions that are responsible for elder care. The aim of this paper was to illuminate the meaning of being in ethically difficult situations related to elder care as experienced by high level decision-makers. Methods A phenomenological-hermeneutic method was used to analyse the eighteen interviews conducted with political and civil servant high level decision-makers at the municipality and county council level from two counties in Sweden. The participants worked at a planning and control as well as executive level and had both budget and quality of elder care responsibilities. Results Both ethical dilemmas and the meaning of being in ethically difficult situations related to elder care were revealed. No differences were seen between the politicians and the civil servants. The ethical dilemmas mostly concerned dealings with extensive care needs and working with a limited budget. The dilemmas were associated with a lack of good care and a lack of agreement concerning care such as vulnerable patients in inappropriate care settings, weaknesses in medical support, dissimilar focuses between the caring systems, justness in the distribution of care and deficient information. Being in ethically difficult situations was challenging. Associated with them were experiences of being exposed, having to be strategic and living with feelings such as aloneness and loneliness, uncertainty, lack of confirmation, the risk of being threatened or becoming a scapegoat and difficult decision avoidance. Conclusion Our paper provides further insight into the ethical dilemmas and ethical challenges met by high level decision-makers', which is important since the overall responsibility for elder care that is also ethically defensible rests with them. They have power and their decisions affect many stakeholders in elder care. Our results can be used to

  20. Ethical challenges related to elder care. High level decision-makers' experiences.

    Science.gov (United States)

    Mamhidir, Anna-Greta; Kihlgren, Mona; Sorlie, Venke

    2007-04-10

    Few empirical studies have been found that explore ethical challenges among persons in high public positions that are responsible for elder care. The aim of this paper was to illuminate the meaning of being in ethically difficult situations related to elder care as experienced by high level decision-makers. A phenomenological-hermeneutic method was used to analyse the eighteen interviews conducted with political and civil servant high level decision-makers at the municipality and county council level from two counties in Sweden. The participants worked at a planning and control as well as executive level and had both budget and quality of elder care responsibilities. Both ethical dilemmas and the meaning of being in ethically difficult situations related to elder care were revealed. No differences were seen between the politicians and the civil servants. The ethical dilemmas mostly concerned dealings with extensive care needs and working with a limited budget. The dilemmas were associated with a lack of good care and a lack of agreement concerning care such as vulnerable patients in inappropriate care settings, weaknesses in medical support, dissimilar focuses between the caring systems, justness in the distribution of care and deficient information. Being in ethically difficult situations was challenging. Associated with them were experiences of being exposed, having to be strategic and living with feelings such as aloneness and loneliness, uncertainty, lack of confirmation, the risk of being threatened or becoming a scapegoat and difficult decision avoidance. Our paper provides further insight into the ethical dilemmas and ethical challenges met by high level decision-makers', which is important since the overall responsibility for elder care that is also ethically defensible rests with them. They have power and their decisions affect many stakeholders in elder care. Our results can be used to stimulate discussions between high level decision-makers and health

  1. A methodological approach to studying resilience mechanisms: demonstration of utility in age and Alzheimer's disease-related brain pathology.

    Science.gov (United States)

    Wolf, Dominik; Fischer, Florian Udo; Fellgiebel, Andreas

    2018-05-01

    The present work aims at providing a methodological approach for the investigation of resilience factors and mechanisms in normal aging, Alzheimer's disease (AD) and other neurodegenerative disorders. By expanding and re-conceptualizing traditional regression approaches, we propose an approach that not only aims at identifying potential resilience factors but also allows for a differentiation between general and dynamic resilience factors in terms of their association with pathology. Dynamic resilience factors are characterized by an increasing relevance with increasing levels of pathology, while the relevance of general resilience factors is independent of the amount of pathology. Utility of the approach is demonstrated in age and AD-related brain pathology by investigating widely accepted resilience factors, including education and brain volume. Moreover, the approach is used to test hippocampal volume as potential resilience factor. Education and brain volume could be identified as general resilience factors against age and AD-related pathology. Beyond that, analyses highlighted that hippocampal volume may not only be disease target but also serve as a potential resilience factor in age and AD-related pathology, particularly at higher levels of tau-pathology (i.e. dynamic resilience factor). Given its unspecific and superordinate nature the approach is suitable for the investigation of a wide range of potential resilience factors in normal aging, AD and other neurodegenerative disorders. Consequently, it may find a wide application and thereby promote the comparability between studies.

  2. Challenges and future direction of molecular research in air pollution-related lung cancers.

    Science.gov (United States)

    Shahadin, Maizatul Syafinaz; Ab Mutalib, Nurul Syakima; Latif, Mohd Talib; Greene, Catherine M; Hassan, Tidi

    2018-04-01

    Hazardous air pollutants or chemical release into the environment by a variety of natural and/or anthropogenic activities may give adverse effects to human health. Air pollutants such as sulphur dioxide (SO2), nitrogen oxides (NOx), carbon monoxide (CO), heavy metals and particulate matter (PM) affect number of different human organs, especially the respiratory system. The International Agency for Research on Cancer (IARC) reported that ambient air pollution is a cause of lung cancer. Recently, the agency has classified outdoor air pollution as well as PM air pollution as Group 1 carcinogens. In addition, several epidemiological studies have shown a positive association between air pollutants to lung cancer risks and mortality. However, there are only a few studies examining the molecular effects of air pollution exposure specifically in lung cancer due to multiple challenges to mimic air pollution exposure in basic experimentation. Another major issue is the lack of adequate adjustments for exposure misclassification as air pollution may differ temporo-spatially and socioeconomically. Thus, the purpose of this paper is to review the current molecular understanding of air pollution-related lung cancer and potential future direction in this challenging yet important research field. Copyright © 2018 Elsevier B.V. All rights reserved.

  3. CHALLENGES AND DILLEMAS WITHIN THE RELATIONS BETWEEN RUSSIA AND THE EUROPEAN UNION

    Directory of Open Access Journals (Sweden)

    Loredana Maria Simionov

    2011-12-01

    Full Text Available Every EU enlargement signified a step towards Central and Eastern Europe, therefore, the 2004 „big bang enlargement”, followed by the one in 2007, modified the geopolitical context within the „old continent” and also increased the importance of the European Union regionally, as well as globally. Integrating the ex-soviet countries into the EU meant taking them out of the Russian sphere of influence, as well as attempting to super size the EU territory in order to increase the European power on a long term. Despite the weakening of Russia after the Cold War, the federation still represents a challenge regarding „pax europea”, as Russia still has an amazing military capacity, as well as important natural resources. The entrance into the Russian sphere of influence, the European energetic dependency on Russia, the conflicts within the separatist regions situated at the EU eastern borders are just few of the many challenges regarding the relations between the European Union and Russia.

  4. Contextual events related to the occurrence of challenging behavior in educational settings

    Directory of Open Access Journals (Sweden)

    Alba CORTINA SERRA

    2017-10-01

    Full Text Available Challenging behaviors (CB displayed by people with intellectual disabilities (ID have a negative effect on their quality of life. The operant theory principles emphasize the relationship between these behaviors and the environment where they take place. This study aimed to identify the contextual variables that are closely related to the occurrence of CB exhibited by children who attend a special school by using an indirect functional assessment instrument; the Contextual Assessment Inventory. Therefore, 17 students have participated in this study where a total of 25 behaviors have been assessed. The results suggested that the social/cultural and the nature of the task or activity categories were more strongly associated with the occurrence of CB. Finally, results are discussed in terms of implications for practitioners. Future researches might address the importance of prevention and universal educational systems.

  5. Experiences addressing health-related financial challenges with disease management among African American women with asthma.

    Science.gov (United States)

    Patel, Minal R; Caldwell, Cleopatra H; Id-Deen, Effat; Clark, Noreen M

    2014-06-01

    Despite economic hardship, compliance with self-management regimens is still evident among individuals and families managing chronic disease. The purpose of this study was to describe how women with asthma address cost-related challenges to management of their condition. In 2012 and 2013, four focus groups were conducted in Southeast Michigan with 26 African American women with asthma, recruited based on maximum variation sampling procedures. A semi-structured interview protocol was employed by trained facilitators. Coded transcripts were analyzed for themes regarding means to reduce the impact of the cost of asthma management. Major themes identified were acceptance of the status quo; stockpiling and sharing medicines; utilizing community assistance programs; reaching out to healthcare providers and social networks for help; foregoing self-management; and utilizing urgent care. Awareness of strategies that are helpful to patients in reducing out-of-pocket costs may better equip service providers and others to develop interventions to make useful strategies more widely available.

  6. T regulatory cells and related immunoregulatory factors in polymorphic light eruption following ultraviolet A1 challenge.

    Science.gov (United States)

    Gambichler, T; Terras, S; Kampilafkos, P; Kreuter, A; Skrygan, M

    2013-12-01

    Polymorphic light eruption (PLE) is considered to be an autoimmune-mediated skin condition in which the normal ultraviolet (UV)-induced local immunosuppression appears to be absent, leading to recognition of photoinduced autoantigens and subsequent inflammation. To investigate T regulatory cells (Tregs) and related immunoregulatory factors in PLE lesions and controls. Skin biopsies were performed in 13 patients with UVA1-challenged PLE, 12 female patients with chronic discoid lupus erythematosus (CDLE) and 11 healthy controls who had exposure to UVA1. Immunohistochemistry and four-colour immunofluorescence studies were performed. Patients with CDLE and UVA1-exposed controls showed significantly decreased epidermal immunoreactivity for CD1a compared with patients with PLE (P = 0·0001). Four-colour immunofluorescence revealed a median percentage of CD4+CD25+FOXP3+ Tregs of 7·6% (range 3·7-13·6%) in PLE, a median of 11·7% (range 9·5-13·9%) in CDLE and a median of 3·4% (range 0-6·8%) in controls. Compared with UVA1-exposed controls, PLE and CDLE lesions showed significantly decreased transforming growth factor (TGF)-β1 immunoreactivity in the epidermis (P = 0·0003). In PLE lesions, we observed significantly decreased interleukin (IL)-10 expression compared with CDLE (P = 0·022). In the dermis, receptor activator of nuclear factor-κB ligand (RANKL) expression was increased in UVA1-exposed controls compared with PLE and CDLE (P = 0·018). Similar to CDLE lesions, UVA1-challenged PLE lesions display an altered immunoregulatory network, as indicated by decreased epidermal or dermal expression of TGF-β1, IL-10 and RANKL, and a relatively low number of Tregs, particularly when compared with other inflammatory skin conditions reported in the literature. © 2013 British Association of Dermatologists.

  7. A protocol for a new methodological model for work-related shoulder complex injuries: From diagnosis to rehabilitation.

    Science.gov (United States)

    Setuain, Igor; Gonzalez-Izal, Miriam; Paularena, Ainara; Luque, Jose Luis; Andersen, Lars L; Izquierdo, Mikel

    2017-02-07

    Work-related injuries of the shoulder complex represent a challenge for clinicians because of the large variety of clinical entities involved and the broad anatomic structures that can be affected. Furthermore, commonly performed orthopedic tests have demonstrated limited accuracy for diagnosing the injury despite considerable research efforts. The aim of this study protocol is therefore to describe a comprehensive approach integrating both a clinical- and functional status-based pathology and an adapted rehabilitation prescription. A longitudinal cohort study will be performed at the Department of Rehabilitation and Medical Assistance of a mutual insurance society for work-related injury management in Spain (Mutua Navarra, Pamplona, Navarra Spain). Patients will be attended by an occupational physician who specializes in work-related injuries and is part of the project team that will systematically visit all the participants. After the medical diagnosis and any requested supplementary evaluations (i.e., radiological examinations), the patients will be referred to the rehabilitation service. Before the physiotherapeutic rehabilitation program is initiated, the patients will undergo a comprehensive functional screening at the biomechanics laboratory. Using a decision-making scheme, the identified functional deficits will be used to customize the individual rehabilitation plan. The proposed objective criteria-based shoulder diagnosis and rehabilitation model could be a new effective strategy for minimizing the time required to regain functional capacity and recover from symptoms among patients with work-related shoulder injuries. The study protocol has been registered on Clinical Trials.gov as NCT02732002 (April 10 th 2016).

  8. Federally Funded Programs Related to Building Energy Use: Overlaps, Challenges, and Opportunities for Collaboration

    Energy Technology Data Exchange (ETDEWEB)

    Cort, Katherine A.; Butner, Ryan S.; Hostick, Donna J.

    2010-10-01

    As energy efficiency in buildings continues to move from discreet technology development to an integrated systems approach, the need to understand and integrate complementary goals and targets becomes more pronounced. Whether within Department of Energy’s (DOE) Building Technologies Program (BTP), across the Office of Energy Efficiency and Renewable Energy (EERE), or throughout DOE and the Federal government, mutual gains and collaboration synergies exist that are not easily achieved because of organizational and time constraints. There also cases where federal agencies may be addressing similar issues, but with different (and sometimes conflicting) outcomes in mind. This report conducts a comprehensive inventory across all EERE and other relevant Federal agencies of potential activities with synergistic benefits. A taxonomy of activities with potential interdependencies is presented. The report identifies a number of federal program objectives, products, and plans related to building energy efficiency and characterizes the current structure and interactions related to these plans and programs. Areas where overlap occurs are identified as are the challenges of addressing issues related to overlapping goals and programs. Based on the input gathered from various sources, including 20 separate interviews with federal agency staff and contractor staff supporting buildings programs, this study identifies a number of synergistic opportunities and makes recommends a number of areas where further collaboration could be beneficial.

  9. The analysis of challenging relations : Influences on interactive behaviour of staff towards clients with intellectual disabilities

    NARCIS (Netherlands)

    Willems, A.P.A.M.; Embregts, P.J.C.M.; Bosman, A.M.T.; Hendriks, A.H.C.

    2014-01-01

    Background Relationships between support staff and clients with intellectual disability (ID) are important for quality of care, especially when dealing with challenging behaviour. Building upon an interpersonal model, this study investigates the influence of client challenging behaviour, staff

  10. Challenging the myth of the irrational dairy farmer; understanding decision-making related to herd health.

    Science.gov (United States)

    Kristensen, E; Jakobsen, E B

    2011-01-01

    Veterinarians working with dairy cows are suggested to refocus their efforts from being task-oriented providers of single-cow therapy and develop themselves into advice-oriented herd health management advisors. The practising cattle veterinarian's ability to translate knowledge into on-farm application requires a profound understanding of the dairy farm as an integrated system. Consequently, educating and motivating farmers are key issues. To achieve such insight the veterinarian needs to work with several scientific disciplines, especially epidemiology and (behavioural) economics. This trans-disciplinary approach offers new methodological possibilities and challenges to students of dairy herd health management. Advisors working with dairy herd health management may sometimes experience that farmers do not follow their advice. Potentially, this could lead to the interpretation that such farmers are behaving irrationally. However, farmers who are confronted with advice suggesting a change of behaviour are placed in a state of cognitive dissonance. To solve such dissonance they may either comply with the advice or reduce the dissonance by convincing themselves that the suggested change in management is impossible to implement. Consequently, herd health management advisors must understand the fundamental and instrumental relationships between individual farmers' values, behaviour and perception of risk, to stimulate and qualify the farmer's decision-making in a way that will increase the farmer's satisfaction and subjective well-being. Traditionally, studies on herd health economics have focussed on financial methods to measure the value of technical outcomes from suggested changes in management, following the basic assumption that farmers strive to maximise profit. Farmers, however, may be motivated by very different activities, e.g. animal health and welfare or other farmers' recognition, making it impossible to provide 'one-size-fts-all' consultancy because the

  11. Testing the validity of a translated pharmaceutical therapy-related quality of life instrument, using qualitative 'think aloud' methodology.

    Science.gov (United States)

    Renberg, T; Kettis Lindblad, A; Tully, M P

    2008-06-01

    In pharmacy practice, there is a need for valid and reliable instruments to study patient-reported outcomes. One potential candidate is a pharmaceutical therapy-related quality of life (PTRQoL) instrument. This study explored the face and content validity, including cognitive aspects of question answering of a PTRQoL instrument, translated from English to Swedish. A sample of 16 customers at Swedish community pharmacies, was asked to fill in the PTRQoL instrument while constantly reporting how they reasoned. The resulting interviews and concurrent probing, were audio-taped, transcribed verbatim and analysed using constant comparison method. The relation between the measurement and its theoretical underpinning was challenged. Respondents neglected to read the instructions, used response options in an unpredictable way, and varied in their interpretations of the items. The combination of 'think-aloud', retrospective probing and qualitative analysis informed on the validity of the PTRQoL instrument and was valuable in questionnaire development. The study also identified specific problems that could be relevant for other instruments probing patients' medicines-related attitudes and behaviour.

  12. Disorders Related to Use of Psychoactive Substances in DSM-5: Changes and Challenges.

    Science.gov (United States)

    Bhad, Roshan; Lal, Rakesh; Balhara, Yatan Pal Singh

    2015-01-01

    In the most recent edition of Diagnostic and Statistical Manual (DSM) that is DSM-5 many modifications have been made in substance use disorder section. These include changes in terminology; sections and categories; diagnostic criteria; threshold for diagnosis; severity; and specifier. Additionally, there have been certain additions and omissions from the earlier version. Critical evaluation of the changes made to the section on disorders related to use of psychoactive substances in India context has not been published so far. The current paper presents a critique of the changes made to the substance use disorder section in DSM-5. The rationale for these changes put forth by DSM-5 work group on substance related disorders have been discussed. Additionally, attempt has been made to highlight the possible future challenges consequent to the current nosological revision for substance use disorder category. Overall DSM-5 seems to be promising in fulfilling its goal of DSM-ICD harmonisation and movement towards an internationally compatible and practical diagnostic system for mental health disorders. It has increased the scope of addiction by inclusion of behavioural addiction. It has also tried to balance the categorical and dimensional approach to diagnosis. However, the real test of this newer edition of one of the most commonly used nosological systems will be during clinical care and research. This will help address the debatable issues regarding the changes that DSM-5 brings with it.

  13. Health challenges of young travelers visiting friends and relatives compared with those traveling for other purposes.

    Science.gov (United States)

    Han, Pauline; Yanni, Emad; Jentes, Emily S; Hamer, Davidson H; Chen, Lin H; Wilson, Mary E; Macleod, William B; Ooi, Winnie W; Kogelman, Laura; Karchmer, Adolf W; Barnett, Elizabeth D

    2012-09-01

    The study objective was to assess differences in demographics and travel health challenges between youths ≤18 years old traveling internationally to visit friends and relatives (VFRs) compared with those traveling for other purposes (non-VFR). The Boston Area Travel Medicine Network consists of 5 clinics collecting anonymous data from international pretravel consultations. Data on all travelers ≤18 years of age seen between January 2008 and July 2010 were used. VFRs were compared with non-VFRs on demographics, primary language, trip characteristics, travel vaccinations administered, malaria prophylaxis and antidiarrheal medications prescribed. Thirty-five percent (610/1731) listed VFR as their purpose of travel. Almost half of VFRs were travel to countries that were yellow fever holoendemic, had malaria risk and were high-risk for typhoid (44% versus 20%, 39% versus 12%, 25% versus 15%, P travel-related morbidity, healthcare providers should be prepared to give travel advice to parents of VFR infants and children, particularly those US-born VFRs with foreign-born parents, regarding antimalarial and antidiarrheal medications and preventing yellow fever, malaria and typhoid.

  14. Synthetic biology as it relates to CAM photosynthesis: challenges and opportunities.

    Science.gov (United States)

    DePaoli, Henrique C; Borland, Anne M; Tuskan, Gerald A; Cushman, John C; Yang, Xiaohan

    2014-07-01

    To meet future food and energy security needs, which are amplified by increasing population growth and reduced natural resource availability, metabolic engineering efforts have moved from manipulating single genes/proteins to introducing multiple genes and novel pathways to improve photosynthetic efficiency in a more comprehensive manner. Biochemical carbon-concentrating mechanisms such as crassulacean acid metabolism (CAM), which improves photosynthetic, water-use, and possibly nutrient-use efficiency, represent a strategic target for synthetic biology to engineer more productive C3 crops for a warmer and drier world. One key challenge for introducing multigene traits like CAM onto a background of C3 photosynthesis is to gain a better understanding of the dynamic spatial and temporal regulatory events that underpin photosynthetic metabolism. With the aid of systems and computational biology, vast amounts of experimental data encompassing transcriptomics, proteomics, and metabolomics can be related in a network to create dynamic models. Such models can undergo simulations to discover key regulatory elements in metabolism and suggest strategic substitution or augmentation by synthetic components to improve photosynthetic performance and water-use efficiency in C3 crops. Another key challenge in the application of synthetic biology to photosynthesis research is to develop efficient systems for multigene assembly and stacking. Here, we review recent progress in computational modelling as applied to plant photosynthesis, with attention to the requirements for CAM, and recent advances in synthetic biology tool development. Lastly, we discuss possible options for multigene pathway construction in plants with an emphasis on CAM-into-C3 engineering. © The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  15. Evaluating the influence of process parameters on soluble microbial products formation using response surface methodology coupled with grey relational analysis.

    Science.gov (United States)

    Xu, Juan; Sheng, Guo-Ping; Luo, Hong-Wei; Fang, Fang; Li, Wen-Wei; Zeng, Raymond J; Tong, Zhong-Hua; Yu, Han-Qing

    2011-01-01

    Soluble microbial products (SMPs) present a major part of residual chemical oxygen demand (COD) in the effluents from biological wastewater treatment systems, and the SMP formation is greatly influenced by a variety of process parameters. In this study, response surface methodology (RSM) coupled with grey relational analysis (GRA) method was used to evaluate the effects of substrate concentration, temperature, NH(4)(+)-N concentration and aeration rate on the SMP production in batch activated sludge reactors. Carbohydrates were found to be the major component of SMP, and the influential priorities of these factors were: temperature>substrate concentration > aeration rate > NH(4)(+)-N concentration. On the basis of the RSM results, the interactive effects of these factors on the SMP formation were evaluated, and the optimal operating conditions for a minimum SMP production in such a batch activated sludge system also were identified. These results provide useful information about how to control the SMP formation of activated sludge and ensure the bioreactor high-quality effluent. Copyright © 2010 Elsevier Ltd. All rights reserved.

  16. Migration-related detention centers: the challenges of an ecological perspective with a focus on justice.

    Science.gov (United States)

    Esposito, Francesca; Ornelas, José; Arcidiacono, Caterina

    2015-06-06

    effective tool to address the multi-level challenges of doing research within them. Furthermore, they can contribute to the development of policies and practices concerned with health, equality, and human rights of all people exposed to migration-related detention. Consistent with these assumptions, empirical studies adopting such a framework are strongly encouraged. These studies should use mixed and multi-method culturally situated designs, based on the development of collaborative and empowering relationships with participants. Ethnographic approaches are recommended.

  17. Keeping Quiet Just Wouldn't be Right: Children's and Adolescents' Evaluations of Challenges to Peer Relational and Physical Aggression.

    Science.gov (United States)

    Mulvey, Kelly Lynn; Killen, Melanie

    2016-09-01

    Youth peer groups hold many different types of norms, including norms supporting aggressive behavior. Challenging or standing up to such aggressive norms can be difficult for children and adolescents, given the pressures to conform to groups. In the current study, the relationship between individual judgments and expectations of the judgments of a peer group about the acceptability of challenging aggressive group norms was investigated. The sample included 9-10 and 13-14 year-olds (N = 292, 52.4 % female). Participants evaluated groups with norms condoning physical and relational aggression. Participants were more supportive of challenges to relational aggression than challenges to physical aggression. Additionally, age-related differences were found, with younger children perceiving challenges to group norms as more feasible than did adolescents. Participants individually rated challenging aggressive norms as okay, but thought that groups would be much less supportive of such challenges. The results also documented the influence of gender stereotypes about aggressive behavior on children's and adolescents' evaluations.

  18. METHODOLOGICAL PROBLEMS OF LAND USE PLANNING LOCALLY IN TERMS OF NEW LAND RELATIONS AND DECENTRALIZATION OF POWER

    Directory of Open Access Journals (Sweden)

    N. Kapinos

    2017-05-01

    Full Text Available Summary Fundamental changes of land relations that have been established for the period of land reform in the independent Ukraine and the new socio-economic and environmental problems identified new character and content of the land. During the land reform in Ukraine to land management encountered new challenges that focus on the implementation of land policy and land relations fundamental change. Accordingly, to land management faces new challenges. Today for events to decentralize power facilities, new land - the territory united local communities should determine for whom the prospect of organizing the use and protection of land and other natural resources. However, the current land law the answer to this problem does not. Instead, normalization is an attempt to issues related to improving the quality of drafting documentation spatial planning (urban planning documents establish procedures for integrated development plans of local communities, the introduction of rules regulating local area to establish procedures for planning, construction and other use areas and about objects, improving public hearings to address public interests and relieve tension in the planning and construction of the territories. However, planning documentation does not solve the problems of perspective development of the organization use and protection of land and other natural resources. There is a need to distinguish between objects of regional urban planning and land management. This is because the urban planning regulations covering mainly two categories of land (settlements, industry, transport, communications and other purposes, not including agricultural land, which houses objects of capital construction. However, they make up for Ukraine just 4.2% of the total area. For the remaining seven categories of land (agricultural land, forest and water resources, conservation, recreation, recreational purposes land use planning and their protection should be based on

  19. Analytical methodology for nuclear safeguards

    International Nuclear Information System (INIS)

    Ramakumar, K.L.

    2011-01-01

    This paper attempts to briefly describe the analytical methodologies available and also highlight some of the challenges, expectations from nuclear material accounting and control (NUMAC) point of view

  20. Experiences addressing health-related financial challenges with disease management among African American women with asthma

    Science.gov (United States)

    Patel, Minal R.; Caldwell, Cleopatra H.; Id-Deen, Effat; Clark, Noreen M.

    2018-01-01

    Objective Despite economic hardship, compliance with self-management regimens is still evident among individuals and families managing chronic disease. The purpose of this study was to describe how women with asthma address cost-related challenges to management of their condition. Methods In 2012 and 2013, four focus groups were conducted in Southeast Michigan with 26 African American women with asthma, recruited based on maximum variation sampling procedures. A semi-structured interview protocol was employed by trained facilitators. Coded transcripts were analyzed for themes regarding means to reduce the impact of the cost of asthma management. Results Major themes identified were acceptance of the status quo; stockpiling and sharing medicines; utilizing community assistance programs; reaching out to healthcare providers and social networks for help; foregoing self-management; and utilizing urgent care. Conclusions Awareness of strategies that are helpful to patients in reducing out-of-pocket costs may better equip service providers and others to develop interventions to make useful strategies more widely available. PMID:24471517

  1. D3R Grand Challenge 2: blind prediction of protein-ligand poses, affinity rankings, and relative binding free energies

    Science.gov (United States)

    Gaieb, Zied; Liu, Shuai; Gathiaka, Symon; Chiu, Michael; Yang, Huanwang; Shao, Chenghua; Feher, Victoria A.; Walters, W. Patrick; Kuhn, Bernd; Rudolph, Markus G.; Burley, Stephen K.; Gilson, Michael K.; Amaro, Rommie E.

    2018-01-01

    The Drug Design Data Resource (D3R) ran Grand Challenge 2 (GC2) from September 2016 through February 2017. This challenge was based on a dataset of structures and affinities for the nuclear receptor farnesoid X receptor (FXR), contributed by F. Hoffmann-La Roche. The dataset contained 102 IC50 values, spanning six orders of magnitude, and 36 high-resolution co-crystal structures with representatives of four major ligand classes. Strong global participation was evident, with 49 participants submitting 262 prediction submission packages in total. Procedurally, GC2 mimicked Grand Challenge 2015 (GC2015), with a Stage 1 subchallenge testing ligand pose prediction methods and ranking and scoring methods, and a Stage 2 subchallenge testing only ligand ranking and scoring methods after the release of all blinded co-crystal structures. Two smaller curated sets of 18 and 15 ligands were developed to test alchemical free energy methods. This overview summarizes all aspects of GC2, including the dataset details, challenge procedures, and participant results. We also consider implications for progress in the field, while highlighting methodological areas that merit continued development. Similar to GC2015, the outcome of GC2 underscores the pressing need for methods development in pose prediction, particularly for ligand scaffolds not currently represented in the Protein Data Bank (http://www.pdb.org), and in affinity ranking and scoring of bound ligands.

  2. Challenges in the management of gas voids in safety related systems

    International Nuclear Information System (INIS)

    Ezekoye, L.I.; Turkowski, W.M.; Ferraraccio, F.P.; Swartz, M.M.

    2009-01-01

    of mechanisms, such as maintenance, gas desorption, vortex activities, cavitation, etc. This paper discusses the sources of gas into safety related systems and the challenges associated with management of gas voids in these systems. Various issues such as gas monitoring, gas purging, gas transport characterization in piping, gas ingestion in safety related pumps, water hammer in discharge piping, and gas impact on the core cooling during design basis accidents are discussed. Industry efforts to support the management of gases in these systems are also presented

  3. Challenges in the management of gas voids in safety related systems

    Energy Technology Data Exchange (ETDEWEB)

    Ezekoye, L.I.; Turkowski, W.M.; Ferraraccio, F.P.; Swartz, M.M. [Westinghouse Electric Company LLC, Pittsburgh (United States)

    2009-04-15

    a number of mechanisms, such as maintenance, gas desorption, vortex activities, cavitation, etc. This paper discusses the sources of gas into safety related systems and the challenges associated with management of gas voids in these systems. Various issues such as gas monitoring, gas purging, gas transport characterization in piping, gas ingestion in safety related pumps, water hammer in discharge piping, and gas impact on the core cooling during design basis accidents are discussed. Industry efforts to support the management of gases in these systems are also presented.

  4. A Grounded Theory of Collaborative Synchronizing in Relation to Challenging Students

    Science.gov (United States)

    Thornberg, Robert

    2012-01-01

    The aim of this study was to investigate multiprofessional collaboration as well as collaboration between professionals and challenging students and their parents in which the focus for these collaborations was on handling the challenging students' academic and social behavior. A grounded theory study of collaboration between a prereferral…

  5. Leadership Challenges of Strategic Research Centres in Relation to Degree of Institutionalisation

    Science.gov (United States)

    Blomqvist, Christine; Agrell, Cecilia; Sandahl, Christer

    2016-01-01

    The purpose of this study was to describe and analyse leadership challenges in the organisation of strategic research centres, focusing on the relationship between organisation and the level of institutionalisation. Four main themes of leadership challenges were identified: (1) the "changing university context," including relationships…

  6. Designing food delivery systems: challenges related to the in vitro methods employed to determine the fate of bioactives in the gut.

    Science.gov (United States)

    Arranz, Elena; Corredig, Milena; Guri, Anilda

    2016-08-10

    An in depth understanding of the underpinning mechanisms that relate to food disruption and processing in the gastrointestinal tract is necessary to achieve optimal intake of nutrients and their bioefficacy. Although in vivo trials can provide insights on physiological responses of nutrients, in vitro assays are often applied as tools to understand specific mechanisms, or as prescreening methods to determine the factors associated with the uptake of food components in the gastrointestinal tract. In vitro assays are also often utilized to design novel or improved food delivery systems. In this review the available approaches to study delivery and uptake of food bioactives and the associated challenges are discussed. For an in depth understanding of food processing in the gastrointestinal tract, it is necessary to apply multidisciplinary methodologies, at the interface between materials science, chemistry, physics and biology.

  7. Teaching Theory of Mind: A Curriculum for Children with High Functioning Autism, Asperger's Syndrome, and Related Social Challenges

    Science.gov (United States)

    Ordetx, Kirstina

    2012-01-01

    This book provides teachers and other professionals with a highly effective, easy-to-follow curriculum for teaching children with high-functioning autism, Asperger syndrome and related social challenges to relate to and interact with others successfully by developing a solid, basic foundation in Theory of Mind (ToM). Dr. Kirstina Ordetx provides…

  8. Exploring the role, needs and challenges of relatives of mothers with HIV or HIV and psychosis: A qualitative study

    NARCIS (Netherlands)

    Spies, Ruan; Derks, Olivia K.; Sterkenburg, Paula S.; Schuengel, Carlo; van Rensburg, Esme

    2016-01-01

    This study explored types and nature of supports by relatives of mothers living with HIV and psychosis in comparison to mothers with HIV only. Interview data on their experiences of their roles, needs and challenges were collected from 33 relatives on mothers with HIV and psychosis (n=12,

  9. Policy Challenges Related to Biofuel Development in Tanzania Politische Herausforderungen in Bezug auf Biokraftstoffe in Tansania

    Directory of Open Access Journals (Sweden)

    Hussein Sosovele

    2010-01-01

    Full Text Available Biofuels have recently emerged as a major issue in energy policy, agricultural development and natural resource management. The growing demand for biofuels is being driven by high oil prices, energy security concerns and global climate change. In Tanzania there is growing interest on the part of foreign private investors in establishing biofuel projects, although globally there are concerns related to biofuel investments. Tanzania has approved a number of such projects, but the biofuel subsector faces several policy challenges that could clearly hamper its development. These include the lack of a holistic and comprehensive energy policy that addresses the broad spectrum of energy options and issues, and weak or absent institutional and legal frameworks. This article highlights some key policy issues critical to the development of biofuels and argues that if these challenges are not addressed at the national policy level, biofuel development may not result in the expected benefits to Tanzania and the majority of its local communities. Biokraftstoffe sind in jüngster Zeit in den Bereichen Energiepolitik, Landwirtschaftsentwicklung und nationales Ressourcenmanagement zu einem wichtigen Thema geworden. Die wachsende Nachfrage nach Biokraftstoffen wird durch die hohen Ölpreise, Befürchtungen in Bezug auf Energiesicherheit und den globalen Klimawandel vorangetrieben. In Tansania ist wachsendes Interesse ausländischer Privatinvestoren an Biokraftstoffprojekten zu beobachten, obwohl es weltweit Bedenken gegenüber solchen Investitionen gibt. Die tansanische Regierung hat einer ganzen Reihe entsprechender Projekte zugestimmt, doch mit dem Biokraftstoffsektor sind politische Herausforderungen verbunden, die diese Entwicklung behindern könnten. Dazu gehören das Fehlen einer ganzheitlichen und umfassenden Energiepolitik, die das ganze Spektrum energiepolitischer Fragestellungen und Optionen einschließt, wie auch schwache oder fehlende institutionelle

  10. PSA methodology

    Energy Technology Data Exchange (ETDEWEB)

    Magne, L

    1997-12-31

    The purpose of this text is first to ask a certain number of questions on the methods related to PSAs. Notably we will explore the positioning of the French methodological approach - as applied in the EPS 1300{sup 1} and EPS 900{sup 2} PSAs - compared to other approaches (Part One). This reflection leads to more general reflection: what contents, for what PSA? This is why, in Part Two, we will try to offer a framework for definition of the criteria a PSA should satisfy to meet the clearly identified needs. Finally, Part Three will quickly summarize the questions approached in the first two parts, as an introduction to the debate. 15 refs.

  11. PSA methodology

    International Nuclear Information System (INIS)

    Magne, L.

    1996-01-01

    The purpose of this text is first to ask a certain number of questions on the methods related to PSAs. Notably we will explore the positioning of the French methodological approach - as applied in the EPS 1300 1 and EPS 900 2 PSAs - compared to other approaches (Part One). This reflection leads to more general reflection: what contents, for what PSA? This is why, in Part Two, we will try to offer a framework for definition of the criteria a PSA should satisfy to meet the clearly identified needs. Finally, Part Three will quickly summarize the questions approached in the first two parts, as an introduction to the debate. 15 refs

  12. Status of Occupational Health and Safety and Related Challenges in Expanding Economy of Tanzania.

    Science.gov (United States)

    Mrema, Ezra J; Ngowi, Aiwerasia V; Mamuya, Simon H D

    2015-01-01

    Occupational health and safety is related with economic activities undertaken in the country. As the economic activities grow and expand, occupational injuries and diseases are more likely to increase among workers in different sectors of economy such as agriculture, mining, transport, and manufacture. This may result in high occupational health and safety services demand, which might be difficult to meet by developing countries that are prioritizing economic expansion without regard to their impact on occupational health and safety. To describe the status of occupational health and safety in Tanzania and outline the challenges in provision of occupational health services under the state of an expanding economy. Tanzania's economy is growing steadily, with growth being driven by communications, transport, financial intermediation, construction, mining, agriculture, and manufacturing. Along with this growth, hazards emanating from work in all sectors of the economy have increased and varied. The workers exposed to these hazards suffer from illness and injuries and yet they are not provided with adequate occupational health services. Services are scanty and limited to a few enterprises that can afford it. Existing laws and regulations are not comprehensive enough to cover the entire population. Implementation of legislation is weak and does not protect the workers. Most Tanzanians are not covered by the occupational health and safety law and do not access occupational health services. Thus an occupational health and safety services strategy, backed by legislations and provided with the necessary resources (competent experts, financial and technological resources), is a necessity in Tanzania. The existing legal provisions require major modifications to meet international requirements and standards. OHS regulations and legislations need refocusing, revision, and strengthening to cover all working population. Capacities should be improved through training and research

  13. Challenging empowerment: AIDS-affected South African children and the need for a multi-level relational approach.

    Science.gov (United States)

    Ansell, Nicola

    2014-01-01

    Critics of empowerment have highlighted the concept's mutability, focus on individual transformation, one-dimensionality and challenges of operationalisation. Relating these critiques to children's empowerment raises new challenges. Drawing on scholarship on children's subjecthood and exercise of power, alongside empirical research with children affected by AIDS, I argue that empowerment envisaged as individual self-transformation and increased capacity to act independently offers little basis for progressive change. Rather it is essential to adopt a relational approach that recognises the need to transform power relationships at multiple levels. This analysis has implications for our wider understanding of empowerment in the 21st century.

  14. Methodological Reflections: Inter- ethnic Research

    DEFF Research Database (Denmark)

    Singla, Rashmi

    2010-01-01

    with both youth and the parental generation with ethnic minority background in Denmark. These reflections include implications and challenges related to researcher’s national, ethnic background and educational, professional position in encounter with   diverse ‘researched persons’ such as youth......This article reflects on the methodological and epistemological aspects of the ethical issues involved in encounters between researcher and research participants with ethnic minority background in contexts with diversity. Specific challenges involved in longitudinal research (10 - 15 years......) are also considered. The issues related to the social relevance of the research deriving from psycho political validity implying consideration of power dynamics in the personal, relational and collective domains are included. The primary basis for these reflections is a follow-up study concerning young...

  15. Breaking the circle: challenging Western sociocultural norms for appearance influences young women's attention to appearance-related media.

    Science.gov (United States)

    Mischner, Isabelle H S; van Schie, Hein T; Engels, Rutger C M E

    2013-06-01

    Paying attention to thin media models may negatively affect women's self-evaluation. This study aimed to reduce the amount of attention that young women give to appearance-related information by challenging the sociocultural norms for appearance, and studied the moderating role of self-esteem. Seventy-one college women either received norm-confirming, norm-challenging, or no information regarding the sociocultural norms for appearance. Subsequently, participants' visual attention to appearance-related and neutral advertisements was measured using an eye-tracker. The results demonstrate that when no information or norm-confirming information was received, women with lower self-esteem paid more attention to the appearance-related advertisements than women with higher self-esteem. Importantly however, when norm-challenging information was received, women with lower self-esteem paid significantly less attention to the appearance-related ads than women with lower self-esteem who did not receive this manipulation. These findings indicate that challenging the sociocultural norms for appearance can attenuate the amount of attention women give to appearance-related media. Copyright © 2013 Elsevier Ltd. All rights reserved.

  16. Significant Attributes and Challenges Related to Cross-Functional Team Communications

    OpenAIRE

    Ali, Majid

    2016-01-01

    Purpose The purpose of the research work is to investigate the importance of the communication in the cross-functional teams and in what which communicational tools provide better convenience of communication in cross-functional team members. Methodology An empirical study including the data collection from the interviews conducted from the participants working in cross-functional teams. Qualitative approach has been adopted to understand the communicational attributes in the cross-functional...

  17. Identification of upregulated immune-related genes in Vibrio harveyi challenged Penaeus monodon postlarvae

    Digital Repository Service at National Institute of Oceanography (India)

    Nayak, S.; Singh, S.K.; Ramaiah, N.; Sreepada, R.A.

    at the early life-stages of shrimps are of great significance. An understanding therefore, of molecular responses and defense mechanism(s) in shrimps against bacterial pathogens is essential. Besides production of antimicrobial biomolecules, the innate... of this strain grown for 24h in seawater nutrient broth were used for the experimental challenge. Cells were harvested by centrifugation and re-suspended in sterilized seawater and the PL were ‘bath’ challenged by adding the harvested cells to attain 2.5- 3...

  18. Talking about epilepsy: Challenges parents face when communicating with their child about epilepsy and epilepsy-related issues.

    Science.gov (United States)

    O'Toole, Stephanie; Lambert, Veronica; Gallagher, Pamela; Shahwan, Amre; Austin, Joan K

    2016-04-01

    The aim of this qualitative study was to explore the challenges that parents of children with epilepsy experienced when engaging in dialog with their child about epilepsy and epilepsy-related issues. Using a qualitative exploratory approach, interviews were conducted with 34 parents of children with epilepsy (aged 6-16 years), consisting of 27 mothers and 7 fathers. Data were transcribed verbatim and thematically analyzed. Findings revealed five main themes: normalizing epilepsy, the invisibility of epilepsy, information concealment, fear of misinforming the child, and difficulty in discussing particular epilepsy-related issues. Many of the communicative challenges experienced by parents impacted on their ability to engage openly in parent-child dialog about epilepsy in the home. Parents face specific challenges when choosing to communicate with their child about epilepsy, relating to creating a sense of normality, reducing fear of causing their child worry, and having a lack of epilepsy-related knowledge. Healthcare professionals who work closely with families living with epilepsy should remain mindful of the importance of discussing family communication surrounding epilepsy and the challenges parents of children with epilepsy face when talking about epilepsy within the home. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Breaking the circle: Challenging Western sociocultural norms for appearance influences young women's attention to appearance-related media

    NARCIS (Netherlands)

    Mischner, I.H.S.; Schie, H.T. van; Engels, R.C.M.E.

    2013-01-01

    Paying attention to thin media models may negatively affect women's self-evaluation. This study aimed to reduce the amount of attention that young women give to appearance-related information by challenging the sociocultural norms for appearance, and studied the moderating role of self-esteem.

  20. Methodological and Reporting Quality of Comparative Studies Evaluating Health-Related Quality of Life of Colorectal Cancer Patients and Controls: A Systematic Review.

    Science.gov (United States)

    Wong, Carlos K H; Guo, Vivian Y W; Chen, Jing; Lam, Cindy L K

    2016-11-01

    Health-related quality of life is an important outcome measure in patients with colorectal cancer. Comparison with normative data has been increasingly undertaken to assess the additional impact of colorectal cancer on health-related quality of life. This review aimed to critically appraise the methodological details and reporting characteristics of comparative studies evaluating differences in health-related quality of life between patients and controls. A systematic search of English-language literature published between January 1985 and May 2014 was conducted through a database search of PubMed, Web of Science, Embase, and Medline. Comparative studies reporting health-related quality-of-life outcomes among patients who have colorectal cancer and controls were selected. Methodological and reporting quality per comparison study was evaluated based on a 11-item methodological checklist proposed by Efficace in 2003 and a set of criteria predetermined by reviewers. Thirty-one comparative studies involving >10,000 patients and >10,000 controls were included. Twenty-three studies (74.2%) originated from European countries, with the largest number from the Netherlands (n = 6). Twenty-eight studies (90.3%) compared the health-related quality of life of patients with normative data published elsewhere, whereas the remaining studies recruited a group of patients who had colorectal cancer and a group of control patients within the same studies. The European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire Core 30 was the most extensively used instrument (n = 16; 51.6%). Eight studies (25.8%) were classified as "probably robust" for clinical decision making according to the Efficace standard methodological checklist. Our further quality assessment revealed the lack of score differences reported (61.3%), contemporary comparisons (36.7%), statistical significance tested (38.7%), and matching of control group (58.1%), possibly leading to

  1. A methodology to compile food metrics related to diet sustainability into a single food database: Application to the French case.

    Science.gov (United States)

    Gazan, Rozenn; Barré, Tangui; Perignon, Marlène; Maillot, Matthieu; Darmon, Nicole; Vieux, Florent

    2018-01-01

    The holistic approach required to assess diet sustainability is hindered by lack of comprehensive databases compiling relevant food metrics. Those metrics are generally scattered in different data sources with various levels of aggregation hampering their matching. The objective was to develop a general methodology to compile food metrics describing diet sustainability dimensions into a single database and to apply it to the French context. Each step of the methodology is detailed: indicators and food metrics identification and selection, food list definition, food matching and values assignment. For the French case, nutrient and contaminant content, bioavailability factors, distribution of dietary intakes, portion sizes, food prices, greenhouse gas emission, acidification and marine eutrophication estimates were allocated to 212 commonly consumed generic foods. This generic database compiling 279 metrics will allow the simultaneous evaluation of the four dimensions of diet sustainability, namely health, economic, social and environmental, dimensions. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Critical review of methodology and application of risk ranking for prioritisation of food and feed related issues, on the basis of the size of anticipated health impact

    DEFF Research Database (Denmark)

    van der Fels-Klerx, H. J.; van Asselt, E. D.; Raley, M.

    , an overarching framework was developed for selection of the appropriate method(s) that could be used for risk ranking of feed and food related hazards, on the basis of human health impact. This framework has the format of a decision tool, with which – given the characteristics of the risk ranking question...... at hand - the most appropriate method(s) can be selected. Application of this overall framework to several case studies showed it can be a useful tool for risk managers/assessors to select the most suitable method for risk ranking of feed/food and diet related hazards, on the basis of expected human......This study aimed to critically review methodologies for ranking of risks related to feed/food safety and nutritional hazards, on the basis of their anticipated human health impact. An extensive systematic literature review was performed to identify and characterize the available methodologies...

  3. Exploring Group Life Design with Teachers in the Context of Poverty Related Psychosocial Challenges

    Science.gov (United States)

    Setlhare, Rubina; Wood, Lesley; Meyer, Lukas

    2017-01-01

    Working in challenging contexts can impact negatively on a teacher's sense of purpose and efficacy. This article explores the potential of group Life Design (LD), a narrative constructivist career counselling process, for supporting ten South African school teachers working at an under-resourced school with understanding their career aspirations…

  4. Struggling to survive: early life challenges in relation to the backtest in pigs

    NARCIS (Netherlands)

    Camerlink, I.; Ursinus, W.W.; Bolhuis, J.E.

    2014-01-01

    Intensively reared piglets may face many early life challenges and these may affect behavior. The objective of this study was to examine the relationship between piglets’ early life circumstances and their behavioral response in a backtest. Hereto, 992 piglets of 14 d of age were subjected to a

  5. Challenges of Dissemination of Islam-related Information for Chinese Muslims in China

    Directory of Open Access Journals (Sweden)

    Ting Ma

    2018-02-01

    Full Text Available This article provided a historical background of the challenges faced in the course of Islamic education of Chinese Muslims in the context of social change. The researcher historically evaluated how social change reshaped the Islamic education of Chinese Muslims, and highlighted the influence of technical developmentonIslamic education in contemporary China. The available research indicated thatsince the 1980s, the challenges faced in the course of Islamic education of Chinese Muslims have gradually shifted from political repercussions to technological development. Due to the limited literature, the researcher called for more research on new media development, especially social mediaand Muslim minority groups in China. The researcher also proposed a research agenda for future studies.

  6. Sino­Pakistan Relations and the Challenges of Post-­Cold War Era

    Directory of Open Access Journals (Sweden)

    Mutahir Ahmed

    2015-04-01

    Full Text Available China has emerged as the world’s second largest economy, and the largest exporter of goods with 9.6 per cent of the global share. Moreover, the last two decades have seen China emerging as an international and regional power of the 21st century. Thus, in order to continue with the economic benefits, China wants peace and stability as well as to play an active role on international and regional fronts. On the other hand, Pakistan, the world’s sixth most populous country, is a major power of South Asia. While having a developed infrastructure and vibrant political and security institutions, Pakistan is nevertheless currently facing many challenges on the economic front, including political instability and religious extremism. This paper is an attempt to analyze the challenges faced by both China and Pakistan in the post-Cold War era.

  7. Stakeholders' perspective on issues and challenges associated with care and treatment of aging-related cognitive impairment disorders in Singapore.

    Science.gov (United States)

    Setia, Monika; Islam, Amina M; Thompson, James P; Matchar, David B

    2011-11-01

    An expanding elderly population poses challenges for the provision of care and treatment for age-related physical and mental disorders. Cognitive impairment (CI)/dementia is one such mental disorder that is on the rise in Singapore and has concomitant implications for social and health systems. The objective of this study is to understand the perspectives of prominent stakeholders about current and future issues and challenges associated with CI/dementia among the elderly in Singapore. Using indepth interviews, this qualitative study obtained the views of multiple stakeholders on issues and challenges associated with CI/dementia in Singapore. The 30 individuals interviewed as part of the study included clinicians, policy-makers, researchers, community workers, administrators, and caregivers. Using a framework approach, interview texts were indexed into domains and issues by utilizing NVivo 9.0 software. The stakeholders expressed concerns related to multiple domains of the CI/dementia care system: attitude and awareness, economics, education, family caregiving, inputs to care system, living arrangements, prevention, screening and diagnosis, and treatment and management of care. Within each domain, multiple issues and challenges were identified by respondents. The study identifies a complex set of inter-related issues and challenges that are associated with the care and treatment of people with CI/dementia. The results suggest that CI and dementia profoundly affect patients, families, and communities and that the issues related to the two disorders are truly system-wide. These findings lay the foundation for utilization of a systems approach to studying CI/dementia and provide an analytic framework for future research on complex health care issues.

  8. Actor groups, related needs, and challenges at the climate downscaling interface

    Science.gov (United States)

    Rössler, Ole; Benestad, Rasmus; Diamando, Vlachogannis; Heike, Hübener; Kanamaru, Hideki; Pagé, Christian; Margarida Cardoso, Rita; Soares, Pedro; Maraun, Douglas; Kreienkamp, Frank; Christodoulides, Paul; Fischer, Andreas; Szabo, Peter

    2016-04-01

    At the climate downscaling interface, numerous downscaling techniques and different philosophies compete on being the best method in their specific terms. Thereby, it remains unclear to what extent and for which purpose these downscaling techniques are valid or even the most appropriate choice. A common validation framework that compares all the different available methods was missing so far. The initiative VALUE closes this gap with such a common validation framework. An essential part of a validation framework for downscaling techniques is the definition of appropriate validation measures. The selection of validation measures should consider the needs of the stakeholder: some might need a temporal or spatial average of a certain variable, others might need temporal or spatial distributions of some variables, still others might need extremes for the variables of interest or even inter-variable dependencies. Hence, a close interaction of climate data providers and climate data users is necessary. Thus, the challenge in formulating a common validation framework mirrors also the challenges between the climate data providers and the impact assessment community. This poster elaborates the issues and challenges at the downscaling interface as it is seen within the VALUE community. It suggests three different actor groups: one group consisting of the climate data providers, the other two groups being climate data users (impact modellers and societal users). Hence, the downscaling interface faces classical transdisciplinary challenges. We depict a graphical illustration of actors involved and their interactions. In addition, we identified four different types of issues that need to be considered: i.e. data based, knowledge based, communication based, and structural issues. They all may, individually or jointly, hinder an optimal exchange of data and information between the actor groups at the downscaling interface. Finally, some possible ways to tackle these issues are

  9. Lost in Translation: The Challenge of Exporting Models of Civil Military Relations

    Science.gov (United States)

    2012-03-01

    society.”27 As Williams has noted, traditional mili- tary culture is confronted by a number of challenges such as cultural relativism and the...imposition of nonmilitary, social, ethical , and political criteria of evaluation on the mili- tary.28 It is these postmodern militaries, and the...members see themselves and what constitutes good governance, ethical behaviour and funda- mental courage.”45 In a study of leadership mythol- ogy in

  10. Hydrogen-related challenges for the steelmaker: the search for proper testing

    Science.gov (United States)

    Thiessen, R. G.

    2017-06-01

    The modern steelmaker of advanced high-strength steels has always been challenged with the conflicting targets of increased strength while maintaining or improving ductility. These new steels help the transportation sector, including the automotive sector, to achieve the goals of increased passenger safety and reduced emissions. With increasing tensile strengths, certain steels exhibit an increased sensitivity towards hydrogen embrittlement (HE). The ability to characterize the material's sensitivity in an as-delivered condition has been developed and accepted (SEP1970), but the complexity of the stress states that can induce an embrittlement together with the wide range of applications for high-strength steels make the development of a standardized test for HE under in-service conditions extremely challenging. Some proposals for evaluating the material's sensitivity give an advantage to materials with a low starting ductility. Despite this, newly developed materials can have a higher original elongation with only a moderate reduction in elongation due to hydrogen. This work presents a characterization of new materials and their sensitivity towards HE. This article is part of the themed issue 'The challenges of hydrogen and metals'.

  11. Using physics-based pose predictions and free energy perturbation calculations to predict binding poses and relative binding affinities for FXR ligands in the D3R Grand Challenge 2

    Science.gov (United States)

    Athanasiou, Christina; Vasilakaki, Sofia; Dellis, Dimitris; Cournia, Zoe

    2018-01-01

    Computer-aided drug design has become an integral part of drug discovery and development in the pharmaceutical and biotechnology industry, and is nowadays extensively used in the lead identification and lead optimization phases. The drug design data resource (D3R) organizes challenges against blinded experimental data to prospectively test computational methodologies as an opportunity for improved methods and algorithms to emerge. We participated in Grand Challenge 2 to predict the crystallographic poses of 36 Farnesoid X Receptor (FXR)-bound ligands and the relative binding affinities for two designated subsets of 18 and 15 FXR-bound ligands. Here, we present our methodology for pose and affinity predictions and its evaluation after the release of the experimental data. For predicting the crystallographic poses, we used docking and physics-based pose prediction methods guided by the binding poses of native ligands. For FXR ligands with known chemotypes in the PDB, we accurately predicted their binding modes, while for those with unknown chemotypes the predictions were more challenging. Our group ranked #1st (based on the median RMSD) out of 46 groups, which submitted complete entries for the binding pose prediction challenge. For the relative binding affinity prediction challenge, we performed free energy perturbation (FEP) calculations coupled with molecular dynamics (MD) simulations. FEP/MD calculations displayed a high success rate in identifying compounds with better or worse binding affinity than the reference (parent) compound. Our studies suggest that when ligands with chemical precedent are available in the literature, binding pose predictions using docking and physics-based methods are reliable; however, predictions are challenging for ligands with completely unknown chemotypes. We also show that FEP/MD calculations hold predictive value and can nowadays be used in a high throughput mode in a lead optimization project provided that crystal structures of

  12. Environmental externalities related to power production on biogas and natural gas based on the EU ExternE methodology

    DEFF Research Database (Denmark)

    Nielsen, Per Sieverts; Ibsen, Liselotte Schleisner

    1998-01-01

    This paper assesses the environmental impacts and external costs from selected electricity generation systems in Denmark. The assessment is carried out as part of the ExternE National Implementation, which is the second phase of the ExternE project and involves case studies from all Western...... European countries. The project use a “bottom-up” methodology to evaluate the external costs associated with a wide range of different fuel cycles. The project has identified priority impacts, where most are impacts from air emissions. Externalities due to atmospheric emissions are calculated through...

  13. Methodology for astronaut reconditioning research.

    Science.gov (United States)

    Beard, David J; Cook, Jonathan A

    2017-01-01

    Space medicine offers some unique challenges, especially in terms of research methodology. A specific challenge for astronaut reconditioning involves identification of what aspects of terrestrial research methodology hold and which require modification. This paper reviews this area and presents appropriate solutions where possible. It is concluded that spaceflight rehabilitation research should remain question/problem driven and is broadly similar to the terrestrial equivalent on small populations, such as rare diseases and various sports. Astronauts and Medical Operations personnel should be involved at all levels to ensure feasibility of research protocols. There is room for creative and hybrid methodology but careful systematic observation is likely to be more achievable and fruitful than complex trial based comparisons. Multi-space agency collaboration will be critical to pool data from small groups of astronauts with the accepted use of standardised outcome measures across all agencies. Systematic reviews will be an essential component. Most limitations relate to the inherent small sample size available for human spaceflight research. Early adoption of a co-operative model for spaceflight rehabilitation research is therefore advised. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. Response to social challenge in young bonnet (Macaca radiata) and pigtail (Macaca nemestrina) macaques is related to early maternal experiences.

    Science.gov (United States)

    Weaver, Ann; Richardson, Rebecca; Worlein, Julie; De Waal, Frans; Laudenslager, Mark

    2004-04-01

    Previous experience affects how young primates respond to challenging social situations. The present retrospective study looked at one aspect of early experience, the quality of the mother-infant relationship, to determine its relationship to young bonnet and pigtail macaques' responses to two social challenges: temporary maternal separation at 5-6 months and permanent transfer to an unfamiliar peer group at 16-17 months. Relationship quality was measured quantitatively on 30 macaque mother-infant pairs with the Relationship Quality Index (RQI), the ratio of relative affiliation to relative agonism as previously applied to capuchin monkeys. Infants with high RQI values had amicable mother-infant relationships and infants with low RQI values had agonistic mother-infant relationships. Young monkeys with amicable and agonistic relationships showed consistent differences in behavior before, during, and after each social challenge, supporting the hypothesis that juveniles from amicable mother-infant relationships based on the RQI coped more effectively with social challenges than did juveniles from agonistic mother-infant relationships. Results suggest 1) characteristic amicability or agonism in early mother-offspring macaque relationships has the potential to influence offspring behavior in tense social contexts and 2) the RQI is useful as one of a coordinated suite of methods for studying the development of social skills. Copyright 2004 Wiley-Liss, Inc.

  15. Obstacles to researching the researchers: a case study of the ethical challenges of undertaking methodological research investigating the reporting of randomised controlled trials.

    Science.gov (United States)

    McKenzie, Joanne E; Herbison, G Peter; Roth, Paul; Paul, Charlotte

    2010-03-21

    Recent cohort studies of randomised controlled trials have provided evidence of within-study selective reporting bias; where statistically significant outcomes are more likely to be more completely reported compared to non-significant outcomes. Bias resulting from selective reporting can impact on meta-analyses, influencing the conclusions of systematic reviews, and in turn, evidence based clinical practice guidelines.In 2006 we received funding to investigate if there was evidence of within-study selective reporting in a cohort of RCTs submitted to New Zealand Regional Ethics Committees in 1998/99. This research involved accessing ethics applications, their amendments and annual reports, and comparing these with corresponding publications. We did not plan to obtain informed consent from trialists to view their ethics applications for practical and scientific reasons. In November 2006 we sought ethical approval to undertake the research from our institutional ethics committee. The Committee declined our application on the grounds that we were not obtaining informed consent from the trialists to view their ethics application. This initiated a seventeen month process to obtain ethical approval. This publication outlines what we planned to do, the issues we encountered, discusses the legal and ethical issues, and presents some potential solutions. Methodological research such as this has the potential for public benefit and there is little or no harm for the participants (trialists) in undertaking it. Further, in New Zealand, there is freedom of information legislation, which in this circumstance, unambiguously provided rights of access and use of the information in the ethics applications. The decision of our institutional ethics committee defeated this right and did not recognise the nature of this observational research. Methodological research, such as this, can be used to develop processes to improve quality in research reporting. Recognition of the potential

  16. Embroidery and Related Manufacturing Techniques for Wearable Antennas: Challenges and Opportunities

    Directory of Open Access Journals (Sweden)

    Aris Tsolis

    2014-05-01

    Full Text Available This paper will review the evolution of wearable textile antennas over the last couple of decades. Particular emphasis will be given to the process of embroidery. This technique is advantageous for the following reasons: (i bespoke or mass produced designs can be manufactured using digitized embroidery machines; (ii glue is not required and (iii the designs are aesthetic and are integrated into clothing rather than being attached to it. The embroidery technique will be compared to alternative manufacturing processes. The challenges facing the industrial and public acceptance of this technology will be assessed. Hence, the key opportunities will be highlighted.

  17. Real-time geomagnetic monitoring for space weather-related applications: Opportunities and challenges

    Science.gov (United States)

    Love, Jeffrey J.; Finn, Carol A.

    2017-07-01

    An examination is made of opportunities and challenges for enhancing global, real-time geomagnetic monitoring that would be beneficial for a variety of operational projects. This enhancement in geomagnetic monitoring can be attained by expanding the geographic distribution of magnetometer stations, improving the quality of magnetometer data, increasing acquisition sampling rates, increasing the promptness of data transmission, and facilitating access to and use of the data. Progress will benefit from new partnerships to leverage existing capacities and harness multisector, cross-disciplinary, and international interests.

  18. Additive Manufacturing of Nickel Superalloys: Opportunities for Innovation and Challenges Related to Qualification

    Science.gov (United States)

    Babu, S. S.; Raghavan, N.; Raplee, J.; Foster, S. J.; Frederick, C.; Haines, M.; Dinwiddie, R.; Kirka, M. K.; Plotkowski, A.; Lee, Y.; Dehoff, R. R.

    2018-06-01

    Innovative designs for turbines can be achieved by advances in nickel-based superalloys and manufacturing methods, including the adoption of additive manufacturing. In this regard, selective electron beam melting (SEBM) and selective laser melting (SLM) of nickel-based superalloys do provide distinct advantages. Furthermore, the direct energy deposition (DED) processes can be used for repair and reclamation of nickel alloy components. The current paper explores opportunities for innovation and qualification challenges with respect to deployment of AM as a disruptive manufacturing technology. In the first part of the paper, fundamental correlations of processing parameters to defect tendency and microstructure evolution will be explored using DED process. In the second part of the paper, opportunities for innovation in terms of site-specific control of microstructure during processing will be discussed. In the third part of the paper, challenges in qualification of AM parts for service will be discussed and potential methods to alleviate these issues through in situ process monitoring, and big data analytics are proposed.

  19. SOME METHODOLOGICAL PROBLEMS IN THE STUDY OF THE INDIVIDUAL OFFENDER IN RELATION TO THE CONCEPT OF "OFFENDER"

    Directory of Open Access Journals (Sweden)

    Novichkov Valery Evgenyevich

    2017-09-01

    Full Text Available The article discusses traditional and non-traditional, but scientifically sound and valid methodological approaches to the study of the individual offender and the offender in their relationship. In particular, substantiate the position criminological approach to the study of criminal behavior of the person and his personality in connection with the set of its biological, physiological, psychological, genetic, "from the outside coming" and other properties and qualities, and in criminal law the offender is to be regarded as persons subject to criminal liability and to include among the currently known characteristics of the individual offender, only those that are covered by the notion "subject of crime". In General, studying the phenomena of the terms "offender" and "offender" should not ignore the data on the "biologization" and "sociological" man, and passing his brain biochemical processes producing motives, feelings, motives, needs etc.

  20. Identifying and evaluating high risk areas and challenges on marine drilling riser system in relation to deepwater problems

    OpenAIRE

    Iversen, Alexander

    2012-01-01

    Master's thesis in Offshore technology The main concerns during drilling operations are riser integrity and maintaining well control. This thesis has mainly been focusing on the problems and challenges faced with the marine riser system to illuminate high risk areas related to riser integrity. A marine riser system consists generally of four main elements; the upper marine riser package, riser joints, lower marine riser package, and the blowout preventer, each playing an important par...

  1. [Methodological aspects in the evaluation of turn-over and up/down sizing as indicators of work-related stress].

    Science.gov (United States)

    Veronesi, G; Bertù, L; Mombelli, S; Cimmino, L; Caravati, G; Conti, M; Abate, T; Ferrario, M M

    2011-01-01

    We discuss the methodological aspects related to the evaluation of turn-over and up-down sizing as indicators of work-related stress, in complex organizations like a university hospital. To estimate the active workers population we developed an algorithm which integrated several administrative databases. The indicators were standardized to take into account some potential confounders (age, sex, work seniority) when considering different hospital structures and job mansions. Main advantages of our method include flexibility in the choice of the analysis detail (hospital units, job mansions, a combination of both) and the possibility to describe over-time trends to measure the success of preventive strategies.

  2. Challenging Assumptions of International Public Relations: When Government Is the Most Important Public.

    Science.gov (United States)

    Taylor, Maureen; Kent, Michael L.

    1999-01-01

    Explores assumptions underlying Malaysia's and the United States' public-relations practice. Finds many assumptions guiding Western theories and practices are not applicable to other countries. Examines the assumption that the practice of public relations targets a variety of key organizational publics. Advances international public-relations…

  3. VALUATION OF INTANGIBLE ASSETS THE MAIN PAWN FOR NEW CHALLENGES RELATED TO THE KNOWLEDGE ERA

    Directory of Open Access Journals (Sweden)

    Paula – Angela VIDRAŞCU

    2014-12-01

    Full Text Available Intangible assets are considered a resource controlled by an economic entity arising from past events that is expected to generate future earnings. Through them we can debate the technical-material and financial developments over time and due to permanent development capacity. Today we are witnessing a constantly changing flow of information found in a perpetual technological change that began the emergence of a new stage in the evolution of society was called knowledge. In this context we talk about the new economy which tries to present more complex reality in which we find ourselves. Evaluation of intangible assets constitute a comprehensive and very complex process that should be treated with great caution, especially since it appears that can lead to new challenges, both because of globalization and the development of technological innovation. It involves understanding the peculiarities of the competence assessment and an independent professional appraiser.

  4. Ethical Challenges when Interviewing Close Relatives Together – An Integrative Review

    DEFF Research Database (Denmark)

    Voltelen, Barbara; Konradsen, Hanne; Østergaard, Birte

    and search terms. Results In total 17 articles were located, 9 containing relevant information about dyadic interviewing, only dealing subtly with questions of ethics. Another 8 articles addressed both dyadic interviewing and ethical considerations. Findings were divided into three different themes......Background and purpose Interviewing two interrelated persons (or more) simultaneously might pose different ethical considerations than interviewing just one person. Such ethical considerations, however, remain largely undescribed in literature, challenging the researcher who wishes to conduct them....... The purpose of this study is to describe the special ethical perspectives concerning joint interviews with interrelated persons. Method An integrative review was performed. A search was conducted in Pub Med, Cinahl, Philosophers Index and Academic Search from 1980 -2014. Data corpus from the 17 articles...

  5. Geophysical Tools, Challenges and Perspectives Related to Natural Hazards, Climate Change and Food Security

    Science.gov (United States)

    Fucugauchi, J. U.

    2013-05-01

    In the coming decades a changing climate and natural hazards will likely increase the vulnerability of agricultural and other food production infrastructures, posing increasing treats to industrialized and developing economies. While food security concerns affect us globally, the huge differences among countries in stocks, population size, poverty levels, economy, technologic development, transportation, health care systems and basic infrastructure will pose a much larger burden on populations in the developing and less developed world. In these economies, increase in the magnitude, duration and frequency of droughts, floods, hurricanes, rising sea levels, heat waves, thunderstorms, freezing events and other phenomena will pose severe costs on the population. For this presentation, we concentrate on a geophysical perspective of the problems, tools available, challenges and short and long-term perspectives. In many instances, a range of natural hazards are considered as unforeseen catastrophes, which suddenly affect without warning, resulting in major losses. Although the forecasting capacity in the different situations arising from climate change and natural hazards is still limited, there are a range of tools available to assess scenarios and forecast models for developing and implementing better mitigation strategies and prevention programs. Earth observation systems, geophysical instrumental networks, satellite observatories, improved understanding of phenomena, expanded global and regional databases, geographic information systems, higher capacity for computer modeling, numerical simulations, etc provide a scientific-technical framework for developing strategies. Hazard prevention and mitigation programs will result in high costs globally, however major costs and challenges concentrate on the less developed economies already affected by poverty, famines, health problems, social inequalities, poor infrastructure, low life expectancy, high population growth

  6. ‘Place’ as conceptual centre: a methodological focus on the bodily relations, movements and expressions of children up to three years of age in kindergarten

    Directory of Open Access Journals (Sweden)

    Karin Hognestad

    2012-12-01

    Full Text Available The purpose of this article is to show how attention on ‘place’ can be productive in methodology concerning the bodily relations, movements and expressions of children up to three years of age who are enrolled in kindergarten. While research that has adopted a hermeneutic and phenomenological approach has contributed to important knowledge concerning young children, we propose re-thinking methodology that takes children’s bodily relations, movements and expressions into concern. Using ‘place’ as a lens, we show how power relations are interrupted and allow for alternative ways for the researcher to relate to data. Inspired by Somerville (2010, elements of place are situated at the centre of the research analysis. The three key elements of place that are put to work are as follows: our relationship to place is constituted in stories and other representations; place learning is local and embodied; and place is a contact zone for cultural contact. The paper is part of a research project which explores how place can be more explicit in educational practices to strengthen kindergarten as a learning arena. We seek to explore how place relations work and what they have the possibility of producing in the analyzing process.

  7. Review Essay: No More Separation between Paid Work and Leisure? Methodological and Empirical Challenges in the Debate about Post-Fordism

    Directory of Open Access Journals (Sweden)

    Birgit Huber

    2005-09-01

    Full Text Available This anthology reflects the spheres of working and living in a neo-liberal society from the viewpoint of cultural studies in European ethnology. Concentrating on daily life, it questions prognoses about regimes of production, new types of manpower and the rediscovery of new structures of society and economy as well as new types of societies. The book is not only about micro-studies—concentrating on micro-studies has often been criticized by both the science of history and cultural studies, which work empirically. The authors of this book work on the basis of ambitious methodological approaches such as "multi-sited-ethnography," which transgresses static fieldwork and is able to grasp the differential between paid work and leisure. These case studies are fully convincing, but reflections about the end of a society in which everyone has a job or about the culture of the "new economy" remain too speculative. The review attempts to place the articles within discussions about changing regimes of production. These discussions began mostly in the field of regulation theory, then in industrial sociology and finally in the sociology of work. Especially innovative methods are considered, which allow the reader to simultaneously analyze the spheres of living and working. URN: urn:nbn:de:0114-fqs050324

  8. A Challenge for Developers: Preserving the Interactivity of Human Relations in a Standalone Application.

    Science.gov (United States)

    Mazur, F. E.

    1993-01-01

    Describes the efforts taken by the Cornell Interactive Theater Ensemble to provide interactive human relations training on date rape using live dramatizations, video with facilitated audience participation, and an electronic multimedia format with decision trees for interactive involvement. (EA)

  9. Towards an optimal adaptation of exposure to NOAA assessment methodology in Multi-Source Industrial Scenarios (MSIS): the challenges and the decision-making process

    Science.gov (United States)

    López de Ipiña, JM; Vaquero, C.; Gutierrez-Cañas, C.

    2017-06-01

    It is expected a progressive increase of the industrial processes that manufacture of intermediate (iNEPs) and end products incorporating ENMs (eNEPs) to bring about improved properties. Therefore, the assessment of occupational exposure to airborne NOAA will migrate, from the simple and well-controlled exposure scenarios in research laboratories and ENMs production plants using innovative production technologies, to much more complex exposure scenarios located around processes of manufacture of eNEPs that, in many cases, will be modified conventional production processes. Here will be discussed some of the typical challenging situations in the process of risk assessment of inhalation exposure to NOAA in Multi-Source Industrial Scenarios (MSIS), from the basis of the lessons learned when confronted to those scenarios in the frame of some European and Spanish research projects.

  10. Methodologies, languages and tools

    International Nuclear Information System (INIS)

    Amako, Katsuya

    1994-01-01

    This is a summary of the open-quotes Methodologies, Languages and Toolsclose quotes session in the CHEP'94 conference. All the contributions to methodologies and languages are relevant to the object-oriented approach. Other topics presented are related to various software tools in the down-sized computing environment

  11. Evaluation of validity and reliability of a methodology for measuring human postural attitude and its relation to temporomandibular joint disorders

    Science.gov (United States)

    Fernández, Ramón Fuentes; Carter, Pablo; Muñoz, Sergio; Silva, Héctor; Venegas, Gonzalo Hernán Oporto; Cantin, Mario; Ottone, Nicolás Ernesto

    2016-01-01

    INTRODUCTION Temporomandibular joint disorders (TMJDs) are caused by several factors such as anatomical, neuromuscular and psychological alterations. A relationship has been established between TMJDs and postural alterations, a type of anatomical alteration. An anterior position of the head requires hyperactivity of the posterior neck region and shoulder muscles to prevent the head from falling forward. This compensatory muscular function may cause fatigue, discomfort and trigger point activation. To our knowledge, a method for assessing human postural attitude in more than one plane has not been reported. Thus, the aim of this study was to design a methodology to measure the external human postural attitude in frontal and sagittal planes, with proper validity and reliability analyses. METHODS The variable postures of 78 subjects (36 men, 42 women; age 18–24 years) were evaluated. The postural attitudes of the subjects were measured in the frontal and sagittal planes, using an acromiopelvimeter, grid panel and Fox plane. RESULTS The method we designed for measuring postural attitudes had adequate reliability and validity, both qualitatively and quantitatively, based on Cohen’s Kappa coefficient (> 0.87) and Pearson’s correlation coefficient (r = 0.824, > 80%). CONCLUSION This method exhibits adequate metrical properties and can therefore be used in further research on the association of human body posture with skeletal types and TMJDs. PMID:26768173

  12. The new Israeli feed safety law: challenges in relation to animal and public health.

    Science.gov (United States)

    Barel, Shimon; Elad, Dani; Cuneah, Olga; Shimshoni, Jakob A

    2017-03-01

    The Israeli feed safety legislation, which came to prominence in the early 1970s, has undergone a major change from simple feed safety and quality regulations to a more holistic concept of control of feed safety and quality throughout the whole feed production chain, from farm to the end user table. In February 2014, a new law was approved by the Israeli parliament, namely the Control of Animal Feed Law, which is expected to enter into effect in 2017. The law is intended to regulate the production and marketing of animal feed, guaranteeing the safety and quality of animal products throughout the production chain. The responsibility on the implementation of the new feed law was moved from the Plant Protection Inspection Service to the Veterinary Services and Animal Health. In preparation for the law's implementation, we have characterized the various sources and production lines of feed for farm and domestic animals in Israel and assessed the current feed safety challenges in terms of potential hazards or undesirable substances. Moreover, the basic requirements for feed safety laboratories, which are mandatory for analyzing and testing for potential contaminants, are summarized for each of the contaminants discussed. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  13. An exploration of neuromorphic systems and related design issues/challenges in dark silicon era

    Science.gov (United States)

    Chandaliya, Mudit; Chaturvedi, Nitin; Gurunarayanan, S.

    2018-03-01

    The current microprocessors has shown a remarkable performance and memory capacity improvement since its innovation. However, due to power and thermal limitations, only a fraction of cores can operate at full frequency at any instant of time irrespective of the advantages of new technology generation. This phenomenon of under-utilization of microprocessor is called as dark silicon which leads to distraction in innovative computing. To overcome the limitation of utilization wall, IBM technologies explored and invented neurosynaptic system chips. It has opened a wide scope of research in the field of innovative computing, technology, material sciences, machine learning etc. In this paper, we first reviewed the diverse stages of research that have been influential in the innovation of neurosynaptic architectures. These, architectures focuses on the development of brain-like framework which is efficient enough to execute a broad set of computations in real time while maintaining ultra-low power consumption as well as area considerations in mind. We also reveal the inadvertent challenges and the opportunities of designing neuromorphic systems as presented by the existing technologies in the dark silicon era, which constitute the utmost area of research in future.

  14. Regulatory challenges related to the licensing of a new nuclear power plant

    International Nuclear Information System (INIS)

    Maris, M.

    2010-01-01

    Assuring the safety and security of nuclear power plants is recognized world-wide as a challenge for all stakeholders. Particular attention goes to plants planned to be built in countries with not sufficiently developed industrial and regulatory infrastructure and experience. A construction and commissioning project, which is usually an international undertaking, gives opportunities to all national stakeholders to develop further their organisations and competences. In the present paper the duties of a regulatory body are recalled as well as the human resources and competences needed for the licensing of a new nuclear power plant. The regulatory body and its technical safety organization(s) should be strengthened and the international cooperation should contribute to this in a systematic and coordinated way. In particular, the donor country should support the necessary development of the regulatory competences and of an effective safety assessment process supporting the national licensing process. Appropriate support can be provided by the International Atomic Energy Agency (IAEA) and through other bi-lateral or multi-lateral programmes

  15. Salvadoran gangs and extortion. Challenges and priorities related to the extortion phenomenon

    Directory of Open Access Journals (Sweden)

    Karla Andrade

    2015-08-01

    Full Text Available During the last few years extortion has garnered a somber relevance for society as a whole, aside from the preponderance it already possessed from law enforcement agents and criminal investigators. The generation of income both in cash and in kind destined for criminal structures, particularly amongst gangs/maras, as well as its implications concerning danger levels and future potential, have made the agencies responsible of public security take a closer look at this crime and ensure there is a full comprehensive assessment made regarding the extortion phenomenon. The above, involved looking into this crime’s different forms of execution, existing enabling factors and the different criminal scenarios it fits into; reviewing how police and prosecutors address these offenses, all operative, investigative and legal implications, as well as the results achieved in the fight against it. Nonetheless, extortionremains a challenge, not only for the institutions involved (Police and the Prosecutor’s Office, but also for the key stakeholders and all those responsible of making strategic decisions for the country.Revista Policía y Seguridad Pública 5(1 2015: 103-148

  16. Knowledge of HIV-related disabilities and challenges in accessing care: Qualitative research from Zimbabwe.

    Directory of Open Access Journals (Sweden)

    Lena Morgon Banks

    Full Text Available While the rapid expansion in antiretroviral therapy access in low and middle income countries has resulted in dramatic declines in mortality rates, many people living with HIV face new or worsening experiences of disability. As nearly 1 in 20 adults are living with HIV in sub-Saharan Africa-many of whom are likely to develop disabling sequelae from long-term infection, co-morbidities and side effects of their treatment-understanding the availability and accessibility of services to address HIV-related disabilities is of vital importance. The aim of this study thus is to explore knowledge of HIV-related disabilities amongst stakeholders working in the fields of HIV and disability and factors impacting uptake and provision of interventions for preventing, treating or managing HIV-related disabilities.In-depth, semi-structured interviews were conducted with ten stakeholders based in Harare, Zimbabwe, who were working in the fields of either disability or HIV. Stakeholders were identified through a priori stakeholder analysis. Thematic Analysis, complemented by constant comparison as described in Grounded Theory, was used to analyse findings.All key informants reported some level of knowledge of HIV-related disability, mostly from observations made in their line of work. However, they reported no interventions or policies were in place specifically to address HIV-related disability. While referrals between HIV and rehabilitation providers were not uncommon, no formal mechanisms had been established for collaborating on prevention, identification and management. Additional barriers to accessing and providing services to address HIV-related disabilities included: the availability of resources, including trained professionals, supplies and equipment in both the HIV and rehabilitation sectors; lack of disability-inclusive adaptations, particularly in HIV services; heavy centralization of available services in urban areas, without accessible, affordable

  17. Aids-related kaposi's sarcoma in a four year old child: the challenge ...

    African Journals Online (AJOL)

    2017-04-01

    Apr 1, 2017 ... KS, endemic (African) KS and iatrogenic (transplanted- related) KS. ... mother so as to prevent mother to child transmission of. HIV. ... use, insect bite or allergy prior to onset of the rashes. ... but there was no history suggestive of sickle cell dis- ease. ... urine microscopy and renal function tests were within.

  18. The Challenges of International Education: Developing a Public Relations Unit for the Asian Region

    Science.gov (United States)

    Fitch, Kate; Surma, Anne

    2006-01-01

    Murdoch University's public relations program attracts a significant number of international students. Up to 60% of students in some units come from Singapore and Malaysia. While many spend at least one year in Australia as part of the three year degree, students in both countries may complete the entire degree offshore from 2007. The authors…

  19. Challenging the 3.0 GPA Eligibility Standard for Public Relations Internships.

    Science.gov (United States)

    Maynard, Michael L.

    1999-01-01

    Analyzes the appropriateness of a 3.0 GPA standard for public relations internship eligibility at one university. Seeks to determine at what GPA cutoff faculty can feel confident that the student will gain from the internship without damaging the program's reputation. Finds students with a 2.7 GPA did as well as students with GPAs ranging from 3.0…

  20. The unique character of traditional forest-related knowledge: threats and challenges ahead

    Science.gov (United States)

    Ronald L. Trosper; John A. Parrotta; Mauro Agnoletti; Vladimir Bocharnikov; Suzanne A. Feary; Monica Gabay; Christian Gamborg; Jesus García Latorre; Elisabeth Johann; Andrey Laletin; Hin Fui Lim; Alfred Oteng-Yeboah; Miguel A. Pinedo-Vasquez; P.S. Ramakrishnan; Yeo-Chang. Youn

    2012-01-01

    This chapter refl ects on the major fi ndings of the lead authors of this book regarding traditional forest-related knowledge (TFRK) using five criteria for distinguishing the unique character of traditional knowledge: (1) its attention to sustainability; (2) relationships to land; (3) identity; (4) reciprocity; and (5) limitations on market involvement. Following an...

  1. Integrating Service Learning into Public Relations Coursework: Applications, Implications, Challenges, and Rewards

    Science.gov (United States)

    Gleason, James P.; Violette, Jayne L.

    2012-01-01

    Drawing on a theoretical framework based on "use-inspired" applied research and service learning practice (Honnet-Porter & Poulsen, 1989), this paper argues the relationship between a service-learning approach and Public Relations coursework is a natural and highly desirable fit. Through examination of the goals of both service-learning and public…

  2. New Media, New Voices: A Complex School Public Relations and Human Resources Challenge

    Science.gov (United States)

    Peck, Craig M.; Mullen, Carol A.

    2008-01-01

    An unprecedented increase in students' personal technology use presents a new area for study within the educational leadership and administration field. Cellular phones, video posting websites, and online social networking destinations empower students to create and distribute school-related images and stories. Student-developed media content can…

  3. Relativity, Quantum Physics and Philosophy in the Upper Secondary Curriculum: Challenges, Opportunities and Proposed Approaches

    Science.gov (United States)

    Henriksen, Ellen K.; Bungum, Berit; Angell, Carl; Tellefsen, Catherine W.; Frågåt, Thomas; Bøe, Maria Vetleseter

    2014-01-01

    In this article, we discuss how quantum physics and relativity can be taught in upper secondary school, in ways that promote conceptual understanding and philosophical reflections. We present the ReleQuant project, in which web-based teaching modules have been developed. The modules address competence aims in the Norwegian national curriculum for…

  4. The Sign of Relation and the Challenges of Journalistic Narratives on the LGBT Community

    Directory of Open Access Journals (Sweden)

    Gean Oliveira Gonçalves

    2018-04-01

    Full Text Available In this article, we present the challenges faced by journalists who interviewed lesbians, gays, bisexuals, transgenders and intersexuals (LGBT to construct narratives and understand the vulnerability that these people must live with, as well as the listening challenges that this process represents. We present a field investigation based on the method of reporting and interview three journalists, understanding their renditions of reports and books they have written on the issue, and elaborating a discussion on the “Sign of Relation”; in other words, how alterity, complexity and complicity can be achieved in journalistic practice; elements that are capable of stimulating authorship and recognizing the differences and inequalities built around gender and sexuality in our societies.   No presente texto, apresentamos os desafios de jornalistas que vão ao encontro de lésbicas, gays, bissexuais, travestis, intersexuais e homens e mulheres transexuais (LGBT para construir narrativas com o devido respeito e compreensão das dimensões de vulnerabilidade em torno da vida dessas pessoas e os desafios de escuta que esse processo representa. Apresentamos uma investida de campo, por meio do método da reportagem, na qual assinalamos as interpretações de três jornalistas sobre seus livros-reportagem com temática LGBT para elaborar uma discussão sobre o “Signo da Relação”, isto é, quais são os caminhos possíveis para alcançar alteridade, complexidade e cumplicidade na prática jornalística, elementos capazes de estimular a autoria e o devido reconhecimento das diferenças e desigualdades construídas em torno do gênero e da sexualidade em nossas sociedades. En este artículo, presentamos los desafíos de periodistas que van al encuentro de lesbianas, gays, bisexuales, travestis, intersexuales y hombres y mujeres transexuales (LGBT para construir narrativas con el debido respeto y comprensión de las dimensiones de vulnerabilidad

  5. Meeting challenges related to the dietary assessment of ethnic minority populations.

    Science.gov (United States)

    Garduño-Diaz, S D; Husain, W; Ashkanani, F; Khokhar, S

    2014-08-01

    Migrants from the Indian subcontinent comprise the largest minority group in the UK. With the process of migration come alterations in lifestyle and eating habits. The present study aimed to disseminate the valuable information, experiences and challenges faced by researchers who conduct studies with ethnic minority groups in the area of diet and nutritional surveys, with an emphasis on migrant South Asians. The findings reported are the result of research carried out during 2008-2012, involving 1100 face-to-face dietary recalls conducted in the UK among South Asian children (aged 1.5-11 years; n = 300) and adults (≥30 years; n = 100). Factors to consider when planning and carrying out diet and nutrition survey studies among migrant South Asians were identified and include the employment of culture-specific tools, visual aid reinforcement and the involvement of key community members and translators to facilitate recruitment and data collection. One of the best practices found when working with minority groups was the use of incentives and tangible benefits to reward study participants. It was also found that constant communication and follow-up of the study participants improved the quality of the data and the likelihood of maintaining links with community members for future studies. From the results of in-house studies and a revision of practices reported in earlier literature, two 24-h face-to-face dietary recalls are recommended as the optimal method for the dietary assessment of migrant South Asians. To complement this assessment, ethnic-specific food frequency questionnaires such as that developed and successfully implemented among South Asians in the present study must be employed. © 2013 The British Dietetic Association Ltd.

  6. Using an autonomous Wave Glider to detect seawater anomalies related to submarine groundwater discharge - engineering challenge

    Science.gov (United States)

    Leibold, P.; Brueckmann, W.; Schmidt, M.; Balushi, H. A.; Abri, O. A.

    2017-12-01

    Coastal aquifer systems are amongst the most precious and vulnerable water resources worldwide. While differing in lateral and vertical extent they commonly show a complex interaction with the marine realm. Excessive groundwater extraction can cause saltwater intrusion from the sea into the aquifers, having a strongly negative impact on the groundwater quality. While the reverse pathway, the discharge of groundwater into the sea is well understood in principle, it's mechanisms and quantities not well constrained. We will present a project that combines onshore monitoring and modeling of groundwater in the coastal plain of Salalah, Oman with an offshore autonomous robotic monitoring system, the Liquid Robotics Wave Glider. Eventually, fluxes detected by the Wave Glider system and the onshore monitoring of groundwater will be combined into a 3-D flow model of the coastal and deeper aquifers. The main tool for offshore SGD investigation project is a Wave Glider, an autonomous vehicle based on a new propulsion technology. The Wave Glider is a low-cost satellite-connected marine craft, consisting of a combination of a sea-surface and an underwater component which is propelled by the conversion of ocean wave energy into forward thrust. While the wave energy propulsion system is purely mechanical, electrical energy for onboard computers, communication and sensors is provided by photovoltaic cells. For the project the SGD Wave Glider is being equipped with dedicated sensors to measure temperature, conductivity, Radon isotope (222Rn, 220Rn) activity concentration as well as other tracers of groundwater discharge. Dedicated software using this data input will eventually allow the Wave Glider to autonomously collect information and actively adapt its search pattern to hunt for spatial and temporal anomalies. Our presentation will focus on the engineering and operational challenges ofdetecting submarine groundwater discharges with the Wave Glider system in the Bay of Salalah

  7. Methodology for the Model-based Small Area Estimates of Cancer-Related Knowledge - Small Area Estimates

    Science.gov (United States)

    The HINTS is designed to produce reliable estimates at the national and regional levels. GIS maps using HINTS data have been used to provide a visual representation of possible geographic relationships in HINTS cancer-related variables.

  8. Guidelines for terms related to chemical speciations and fractionation of elements : definitions, structural aspects, and methodological approaches (IUPAC Recommendations 2000)

    NARCIS (Netherlands)

    Templeton, D.M.; Ariese, F.; Cornelis, R.; Danielsson, L.G.; Muntau, H.; Leeuwen, van H.P.; Lobínski, R.

    2000-01-01

    This paper presents definitions of concepts related to speciation of elements, more particularly speciation analysis and chemical species. Fractionation is distinguished from speciation analysis, and a general outline of fractionation procedures is given. We propose a categorization of species

  9. The Importance of Methodology Evaluation of School Furniture for Czech Children with Mobility Disability in Relation to Children’s Anthropometry

    Directory of Open Access Journals (Sweden)

    Martin Zach

    2014-01-01

    Full Text Available The paper presents results of research conducted under the support of the IGA LDF MENDELU project, id. No. 32/2010 (Anthropometry in Disabled Children in Relation to Furniture and the NIS MPO ČR FR-TI1/050 project (Information System for the Support of Research, Development, Innovation and Furniture Quality. It gives an account of theoretical and methodological foundations, introduces the project’s research objectives. Its major objective is to familiarise professional public with the results of the conducted research the focus of which was to determine requirements for furniture designated for children with mobility restrictions. The defined requirements then constitute the grounds of school furniture assessment methodology. These requirements are divided into three levels that are somehow interconnected. Application of the methodology as a whole is highly wide and can be directed at all educational institutions in the Czech Republic with the pupils from the target group. The evaluation outcome is a report of each evaluated product. The questions raised also belong to a broader context of the issue at hand, related to the project of protection and safety standards establishment in relation to health status of children and youth, in the context of the “Long-term programme of the improvement of health status of the Czech Republic population – Health for everybody in the 21st century” paper, objective 4: HEALTH OF YOUTH – TO BUILD CONDITIONS FOR YOUNG PEOPLE TO BECOME HEALTHIER AND APTER TO FULFILL THEIR ROLE IN THE SOCIETY BY 2020. It is recommended to make a proper definition of the dimensional characteristics of children and update their measurements for furniture design in the Czech Republic constantly (including revision of technical regulations and innovation dimensions in the literature. This can be considered as an opportunity to improve the health of future generations.

  10. The Challenge Treatment of Medication Related Osteonecrosis of the Jaw: A Case Report

    OpenAIRE

    M Rodríguez Sánchez; Bassi AP; Carvalho PS

    2015-01-01

    Bisphosphonates toxicological effect on alveolar bone could be associated to medication related osteonecrosis of the jaw. (MRONJ) Oral surgical procedures as; tooth extractions, implants placements or trauma are suggested risk factors. The aim of this paper is to describe a case of MRONJ and recurrence after the first right mandibular molar extraction. A 54 years old man was referred to the Department of Surgery and Integrated Clinic of Aracatuba Dental School, Univ. Estadual Paulista - UNESP...

  11. Responding to the challenge of leprosy-related disability and ultra-poverty.

    Science.gov (United States)

    Bowers, Bob; Singh, Suren; Kuipers, Pim

    2014-09-01

    The Millennium Development Goals have provided much needed attention to extreme poverty reduction. However, people with disabilities are disproportionately affected by poverty and in some countries, even the goal of US$1 per day is far out of reach. For people with leprosy-related disability living in ultra-poverty (on less than 50 cents a day), many mainstream poverty reduction strategies are inaccessible and inappropriate. A project in north-west Bangladesh developed a more contextually meaningful definition of ultra-poverty according to nutrition energy intake. A total of 2372 people with leprosy-related disability were surveyed. Of those, 1285 individuals fell below the ultra-poverty line. Individualised interventions were implemented over an extended period of time, comprised of targeted practical assistance, enhancing community links, advocacy for entitlements, and further linking with other initiatives. Follow-up data available for 856 individuals showed an average increase in per capita income of 83%. Personal contribution to the family income increased by 65%. There was a 51% increase in families having access to a latrine. Finally families reported eating 30% more meals per day, up from an average of two meals per day. The initiative sought to address poverty in a wide variety of ways, using minimal inputs. Over several years, the results indicate a significant change in the economic situation of individuals with leprosy related disabilities. Other organisations are encouraged to duplicate the intervention and share their results.

  12. Notes on methodology and pitfalls in science and research and on communication of results. Some aspects related to EMF; Synpunkter paa metodik och fallgropar inom vetenskap och forskning samt hur resultaten kommuniceras. Naagra aspekter relaterade till EMF

    Energy Technology Data Exchange (ETDEWEB)

    Cedervall, Bjoern (Unit of Med. Radiation Physics and Med. Radiation Biology, Dept. Oncology and Pathology, Karolinska Inst., Stockholm (Sweden))

    2009-06-15

    There are many aspects of the controversy around EMF and potential risks that are largely unknown to the wider audience. Such aspects form the basis for the topics discussed in this report. More specifically focus has been on arguments related to possible cause-effect where linguistic barriers and societal 'filters' (for instance by uncritical media) may constitute a problem. Regardless of whether scientists are working with for example molecular biology or epidemiology they are confronted with a number of methodological problems that may be difficult or even impossible to master. Such difficulties are seldom seen in press releases, news media and so on but they may still be part of many scientists' daily challenges. The most difficult communication challenge is probably that if something is absolutely safe it cannot be proven. An unknown virus, bacterium, or chemical contaminant may completely ruin experiments in a molecular biology experiment but at least the experiments can be repeated and often measures can be taken once such a contamination has been found. For epidemiological studies there is always a specific challenge in that the investigations cannot be repeated as people never do the same things under the same conditions and in a predictable manner. It is with this background and context that the author has chosen to treat some methodological problems in science as well as the so-called Hill's criteria for cause-effects. A shorter comment has been made with reference to various aspects of the precautionary principle as it is often referred to in the EMF debate but most often, however, it has seldom been clarified what is meant by precautionary practices or actions. Precaution is closely related to human fear and therefore a corresponding chapter has been included. This report ends with a few looks into the historical rear-view mirror which illuminates the anticipated benefits with the invisible and mystical rather than the potential

  13. Signal transduction-related responses to phytohormones and environmental challenges in sugarcane

    Directory of Open Access Journals (Sweden)

    Hemerly Adriana S

    2007-03-01

    Full Text Available Abstract Background Sugarcane is an increasingly economically and environmentally important C4 grass, used for the production of sugar and bioethanol, a low-carbon emission fuel. Sugarcane originated from crosses of Saccharum species and is noted for its unique capacity to accumulate high amounts of sucrose in its stems. Environmental stresses limit enormously sugarcane productivity worldwide. To investigate transcriptome changes in response to environmental inputs that alter yield we used cDNA microarrays to profile expression of 1,545 genes in plants submitted to drought, phosphate starvation, herbivory and N2-fixing endophytic bacteria. We also investigated the response to phytohormones (abscisic acid and methyl jasmonate. The arrayed elements correspond mostly to genes involved in signal transduction, hormone biosynthesis, transcription factors, novel genes and genes corresponding to unknown proteins. Results Adopting an outliers searching method 179 genes with strikingly different expression levels were identified as differentially expressed in at least one of the treatments analysed. Self Organizing Maps were used to cluster the expression profiles of 695 genes that showed a highly correlated expression pattern among replicates. The expression data for 22 genes was evaluated for 36 experimental data points by quantitative RT-PCR indicating a validation rate of 80.5% using three biological experimental replicates. The SUCAST Database was created that provides public access to the data described in this work, linked to tissue expression profiling and the SUCAST gene category and sequence analysis. The SUCAST database also includes a categorization of the sugarcane kinome based on a phylogenetic grouping that included 182 undefined kinases. Conclusion An extensive study on the sugarcane transcriptome was performed. Sugarcane genes responsive to phytohormones and to challenges sugarcane commonly deals with in the field were identified

  14. Methodology for the calculation of source terms related to irradiated fuel accumulated away from nuclear power plants

    International Nuclear Information System (INIS)

    Lima Filho, R.M.; Oliveira, L.F.S. de

    1984-01-01

    A general method for the calculation of the time evolution of source terms related to irradiated fuel is presented. Some applications are discussed which indicated that the method can provide important informations for the engineering design and safety analysis of a temporary storage facility of irradiated fuel elements. (Author) [pt

  15. Relational Discrimination by Pigeons in a Go/No-Go Procedure with Compound Stimuli: A Methodological Note

    Science.gov (United States)

    Campos, Heloisa Cursi; Debert, Paula; Barros, Romariz da Silva; McIlvane, William J.

    2011-01-01

    A go/no-go procedure with compound stimuli typically establishes emergent behavior that parallels in structure and typical outcome that of conventional tests for symmetric, transitive, and equivalence relations in normally capable adults. The present study employed a go/no-go compound stimulus procedure with pigeons. During training, pecks to…

  16. Relative binding affinity prediction of farnesoid X receptor in the D3R Grand Challenge 2 using FEP+

    Science.gov (United States)

    Schindler, Christina; Rippmann, Friedrich; Kuhn, Daniel

    2018-01-01

    Physics-based free energy simulations have increasingly become an important tool for predicting binding affinity and the recent introduction of automated protocols has also paved the way towards a more widespread use in the pharmaceutical industry. The D3R 2016 Grand Challenge 2 provided an opportunity to blindly test the commercial free energy calculation protocol FEP+ and assess its performance relative to other affinity prediction methods. The present D3R free energy prediction challenge was built around two experimental data sets involving inhibitors of farnesoid X receptor (FXR) which is a promising anticancer drug target. The FXR binding site is predominantly hydrophobic with few conserved interaction motifs and strong induced fit effects making it a challenging target for molecular modeling and drug design. For both data sets, we achieved reasonable prediction accuracy (RMSD ≈ 1.4 kcal/mol, rank 3-4 according to RMSD out of 20 submissions) comparable to that of state-of-the-art methods in the field. Our D3R results boosted our confidence in the method and strengthen our desire to expand its applications in future in-house drug design projects.

  17. Relative binding affinity prediction of farnesoid X receptor in the D3R Grand Challenge 2 using FEP.

    Science.gov (United States)

    Schindler, Christina; Rippmann, Friedrich; Kuhn, Daniel

    2018-01-01

    Physics-based free energy simulations have increasingly become an important tool for predicting binding affinity and the recent introduction of automated protocols has also paved the way towards a more widespread use in the pharmaceutical industry. The D3R 2016 Grand Challenge 2 provided an opportunity to blindly test the commercial free energy calculation protocol FEP+ and assess its performance relative to other affinity prediction methods. The present D3R free energy prediction challenge was built around two experimental data sets involving inhibitors of farnesoid X receptor (FXR) which is a promising anticancer drug target. The FXR binding site is predominantly hydrophobic with few conserved interaction motifs and strong induced fit effects making it a challenging target for molecular modeling and drug design. For both data sets, we achieved reasonable prediction accuracy (RMSD ≈ 1.4 kcal/mol, rank 3-4 according to RMSD out of 20 submissions) comparable to that of state-of-the-art methods in the field. Our D3R results boosted our confidence in the method and strengthen our desire to expand its applications in future in-house drug design projects.

  18. CHALLENGES AND OPPORTUNITIES TH E INSURANCE INDU STRY FACING WITH IN RELATION TO CLIMATE CHANGE

    Directory of Open Access Journals (Sweden)

    Fekete Mária FARKASNÉ

    2010-07-01

    Full Text Available Apart from the financial risk the insurance industry are facing with in association with climate change, there are also opportun ities to the sector to develop new markets and provide coverage against weather related risks. This study presents a possible method to examine the potential for introducing a new insurance product, namely an agricultural flood insurance scheme in the United Kingdom. The investigation included the calculation of agricultural flood damage costs, the possible changes in flood risk, the description of farmers’ risk attitude and interests in insurance. In a small scale survey, farmers were asked their experiences related to flooding, farm management practices and thei r willingness to pay for flood insurance using a contingent valuation method. Using statistical analysis it was found the insurance demand is positively correlated with the damage cost predicted and association is likely between farm types and WTP for insurance. Linear regression model suggests that the demand for flood insurance is low amongst farmers in the present risk level. The findi ngs of this research highlight that there is little evidence for the viability of a farmer financed agricultural flood insurance scheme at the moment in the United Kingdom.

  19. Challenges and Outcome of Innovative Behavior: A Qualitative Study of Tourism Related Entrepreneurs

    Directory of Open Access Journals (Sweden)

    Azmil Munif Mohd Bukhari

    2012-07-01

    Full Text Available The tourism industry is currently Malaysia’s third most important industry in terms of foreign exchange earnings after the manufacturing and palm oil sectors. Its contribution to GDP growth is about 7.2%, suggesting that the industry is still in its infancy and therefore offers much scope for future growth. Furthermore tourism industry has been recognized as important economic activities especially during the current economic crisis. Malaysian government announced as part of the Mini Budget tabled in parliament on 10th March 2009 that RM200 million will be allocated to various tourism related programs. However, tourism industry is in a downward spiral due to various reasons such as global economic crisis and strong competition from other countries. Innovative efforts are necessary to further promote this industry so as to reap the full benefits and potential of this sector, besides giving it a competitive edge against its competitors like Thailand, Hong Kong and Singapore. Emphasis should be given to the development of competitive tourism products or services to enhance foreign exchange earnings and savings. Innovative approach such as creativity is the key element for success. This paper attempts to synthesize the scope and role of innovation in the determination of effectiveness of tourism related entrepreneurs. Furthermore, this paper proposed that strategic innovativeness and behavioral innovativeness enhance performance of entrepreneurs.

  20. Global nuclear renaissance - today's issues, challenges and differences relative to the first wave of nuclear plant projects

    International Nuclear Information System (INIS)

    Gardner, William N.

    2010-01-01

    The development and negotiation of an Engineering, Procurement and Construction (EPC) contract is a multi-disciplined and time consuming process. Relative to the first wave on new nuclear build projects of the 1950's - 1970's, today's EPC contracts are more complex for a variety of reasons including more demanding regulatory and environmental requirements, global supply chain versus localization issues and different world wide economic considerations. This paper discusses the impacts of some of these challenges on developing an EPC contract in today's Nuclear Renaissance. (authors)

  1. Adverse events and the relation with quality of life in adults with intellectual disability and challenging behaviour using psychotropic drugs.

    Science.gov (United States)

    Scheifes, Arlette; Walraven, Sanne; Stolker, Joost Jan; Nijman, Henk L I; Egberts, Toine C G; Heerdink, Eibert R

    2016-01-01

    Psychotropic drugs are prescribed to approximately 30-40% of adults with intellectual disability (ID) and challenging behaviour, despite the limited evidence of effectiveness and the potential of adverse events. To assess the prevalence of adverse events in association with psychotropic drug use in adults with ID and challenging behaviour and to examine the relation of these adverse events with the person's quality of life. The presence of adverse events was measured with a questionnaire that had to be filled in by the physicians of the participants. Movement disorders were measured separately with a standardised protocol. The strength of the association between adverse events and Intellectual Disability Quality of Life-16 (IDQOL-16), and daily functioning was investigated using linear regression analyses, taking into account the severity of disease (CGI-S) as potential confounder. Virtually all of 103 adults with ID and challenging behaviour had at least one adverse event (84.4%) and almost half had ≥3 adverse events (45.6%) across different subclasses. Using psychotropic drugs increased the prevalence of adverse events significantly. Respectively 13% of the patients without psychotropic drugs and 61% of the patients with ≥2 psychotropic drugs had ≥3 adverse events. Having adverse events had a significantly negative influence on the quality of life. A large majority of all patients had at least one adverse event associated with psychotropic drug use. More attention is needed for these adverse events and their negative influence on the quality of life of these patients, taking into account the lack of evidence of effectiveness of psychotropic drugs for challenging behaviour. Copyright © 2015. Published by Elsevier Ltd.

  2. The Challenge of Electrochemical Ammonia Synthesis: A New Perspective on the Role of Nitrogen Scaling Relations.

    Science.gov (United States)

    Montoya, Joseph H; Tsai, Charlie; Vojvodic, Aleksandra; Nørskov, Jens K

    2015-07-08

    The electrochemical production of NH3 under ambient conditions represents an attractive prospect for sustainable agriculture, but electrocatalysts that selectively reduce N2 to NH3 remain elusive. In this work, we present insights from DFT calculations that describe limitations on the low-temperature electrocatalytic production of NH3 from N2 . In particular, we highlight the linear scaling relations of the adsorption energies of intermediates that can be used to model the overpotential requirements in this process. By using a two-variable description of the theoretical overpotential, we identify fundamental limitations on N2 reduction analogous to those present in processes such as oxygen evolution. Using these trends, we propose new strategies for catalyst design that may help guide the search for an electrocatalyst that can achieve selective N2 reduction. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Growing inter-Asian connections: Links, rivalries, and challenges in South Korean–Central Asian relations

    Directory of Open Access Journals (Sweden)

    Matteo Fumagalli

    2016-01-01

    Full Text Available The geopolitical context, which emerged from the collapse of the Soviet Union and the end of the Cold War, combined with Korea's growing economic prowess, enabled greater dynamism and diversification in Seoul's foreign policy-making. Growing pressure from energy-intensive economies coupled with new developments and investment in logistics and infrastructure has brought different parts of the Eurasian landmass closer together in recent years. Inter-Asian connections are especially growing. This article uses the case of deepening relations between Korea and the post-Soviet Central Asian republics as a vantage point to reflect on one such example of unfolding Asian inter-connectedness. In addition it sees Seoul's engagement in the region as a fitting example of Korea's broader ambitions to assert itself as a global economic player. The article shows that Korea's policy toward Central Asia has been primarily driven by energy needs and is defined by pragmatism. It finds that the economic dimension of the relationship has greatly overshadowed other aspects such as politics and security. In its pursuit of closer ties with the region Seoul has sought to turn structural weaknesses into added value and has attempted to develop a distinctive, non-threatening profile built around the lack of a political baggage and geopolitical ambitions, and the desire to share its experience of formerly impoverished turned leading economy. In turn, Central Asia's selective integration in the world economy has continued, also thanks to its ties with Korea. The Central Asian republics welcomed the opportunity to diversify their foreign relations, the sources of foreign investment and export routes. At the same time the opaque business environment, a leadership succession, which cannot be postponed for much longer, and Seoul's “no-strings attached” approach expose Korea to some risks as regime stability might not last forever.

  4. Open intensive care units: a global challenge for patients, relatives, and critical care teams.

    Science.gov (United States)

    Cappellini, Elena; Bambi, Stefano; Lucchini, Alberto; Milanesio, Erika

    2014-01-01

    The aims of this study were to describe the current status of intensive care unit (ICU) visiting hours policies internationally and to explore the influence of ICUs' open visiting policies on patients', visitors', and staff perceptions, as well as on patients' outcomes. A review of the literature was done through MEDLINE, EMBASE, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases. The following keywords were searched: "visiting," "hours," "ICU," "policy," and "intensive care unit." Inclusion criteria for the review were original research paper, adult ICU, articles published in the last 10 years, English or Italian language, and available abstract. Twenty-nine original articles, mainly descriptive studies, were selected and retrieved. In international literature, there is a wide variability about open visiting policies in ICUs. The highest percentage of open ICUs is reported in Sweden (70%), whereas in Italy there is the lowest rate (1%). Visiting hours policies and number of allowed relatives are variable, from limits of short precise segments to 24 hours and usually 2 visitors. Open ICUs policy/guidelines acknowledge concerns with visitor hand washing to prevent the risk of infection transmission to patients. Patients, visitors, and staff seem to be inclined to support open ICU programs, although physicians are more inclined to the enhancement of visiting hours than nurses. The percentages of open ICUs are very different among countries. It can be due to local factors, cultural differences, and lack of legislation or hospital policy. There is a need for more studies about the impact of open ICUs programs on patients' mortality, length of stay, infections' risk, and the mental health of patients and their relatives.

  5. Social Responsibility of Partners of Labour Relations as a Factor of Rational Use of Labour Potential: Theoretical and Methodological Approach

    OpenAIRE

    Serikova Olga M.

    2013-01-01

    The article considers social responsibility of the employer and employee as a component of the socially responsible business. It identifies that social responsibility should be directed at such components as introduction of social programmes and improvement of labour conditions; establishment of the social dialogue; business self-perfection that is realised in responsibility for results of labour; increase of responsibility when performing work; use of ethic principles of relations with colle...

  6. The challenge of AIDS-related malignancies in sub-Saharan Africa.

    Directory of Open Access Journals (Sweden)

    Annie J Sasco

    Full Text Available BACKGROUND: With the lengthening of life expectancy among HIV-positive subjects related to the use of highly active antiretroviral treatments, an increased risk of cancer has been described in industrialized countries. The question is to determine what occurs now and will happen in the future in the low income countries and particularly in sub-Saharan Africa where more than two-thirds of all HIV-positive people live in the world. The objective of our paper is to review the link between HIV and cancer in sub-Saharan Africa, putting it in perspective with what is already known in Western countries. METHODS AND FINDINGS: Studies for this review were identified from several bibliographical databases including Pubmed, Scopus, Cochrane, Pascal, Web of Science and using keywords "HIV, neoplasia, epidemiology and Africa" and related MesH terms. A clear association was found between HIV infection and AIDS-classifying cancers. In case-referent studies, odds ratios (OR were ranging from 21.9 (95% Confidence Interval (CI 12.5-38.6 to 47.1 (31.9-69.8 for Kaposi sarcoma and from 5.0 (2.7-9.5 to 12.6 (2.2-54.4 for non Hodgkin lymphoma. The association was less strong for invasive cervical cancer with ORs ranging from 1.1 (0.7-1.2 to 1.6 (1.1-2.3, whereas ORs for squamous intraepithelial lesions were higher, from 4.4 (2.3-8.4 to 17.0 (2.2-134.1. For non AIDS-classifying cancers, squamous cell conjunctival carcinoma of the eye was associated with HIV in many case-referent studies with ORs from 2.6 (1.4-4.9 to 13.0 (4.5-39.4. A record-linkage study conducted in Uganda showed an association between Hodgkin lymphoma and HIV infection with a standardized incidence ratio of 5.7 (1.2-17 although OR in case-referent studies ranged from 1.4 (0.7-2.8 to 1.6 (1.0-2.7. Other cancer sites found positively associated with HIV include lung, liver, anus, penis, vulva, kidney, thyroid and uterus and a decreased risk of female breast cancer. These results so far based on a

  7. The challenge of AIDS-related malignancies in sub-Saharan Africa.

    Science.gov (United States)

    Sasco, Annie J; Jaquet, Antoine; Boidin, Emilie; Ekouevi, Didier K; Thouillot, Fabian; Lemabec, Thomas; Forstin, Marie-Anna; Renaudier, Philippe; N'dom, Paul; Malvy, Denis; Dabis, François

    2010-01-11

    With the lengthening of life expectancy among HIV-positive subjects related to the use of highly active antiretroviral treatments, an increased risk of cancer has been described in industrialized countries. The question is to determine what occurs now and will happen in the future in the low income countries and particularly in sub-Saharan Africa where more than two-thirds of all HIV-positive people live in the world. The objective of our paper is to review the link between HIV and cancer in sub-Saharan Africa, putting it in perspective with what is already known in Western countries. Studies for this review were identified from several bibliographical databases including Pubmed, Scopus, Cochrane, Pascal, Web of Science and using keywords "HIV, neoplasia, epidemiology and Africa" and related MesH terms. A clear association was found between HIV infection and AIDS-classifying cancers. In case-referent studies, odds ratios (OR) were ranging from 21.9 (95% Confidence Interval (CI) 12.5-38.6) to 47.1 (31.9-69.8) for Kaposi sarcoma and from 5.0 (2.7-9.5) to 12.6 (2.2-54.4) for non Hodgkin lymphoma. The association was less strong for invasive cervical cancer with ORs ranging from 1.1 (0.7-1.2) to 1.6 (1.1-2.3), whereas ORs for squamous intraepithelial lesions were higher, from 4.4 (2.3-8.4) to 17.0 (2.2-134.1). For non AIDS-classifying cancers, squamous cell conjunctival carcinoma of the eye was associated with HIV in many case-referent studies with ORs from 2.6 (1.4-4.9) to 13.0 (4.5-39.4). A record-linkage study conducted in Uganda showed an association between Hodgkin lymphoma and HIV infection with a standardized incidence ratio of 5.7 (1.2-17) although OR in case-referent studies ranged from 1.4 (0.7-2.8) to 1.6 (1.0-2.7). Other cancer sites found positively associated with HIV include lung, liver, anus, penis, vulva, kidney, thyroid and uterus and a decreased risk of female breast cancer. These results so far based on a relatively small number of studies warrant

  8. Health-related external cost assessment in Europe: methodological developments from ExternE to the 2013 Clean Air Policy Package.

    Science.gov (United States)

    van der Kamp, Jonathan; Bachmann, Till M

    2015-03-03

    "Getting the prices right" through internalizing external costs is a guiding principle of environmental policy making, one recent example being the EU Clean Air Policy Package released at the end of 2013. It is supported by impact assessments, including monetary valuation of environmental and health damages. For over 20 years, related methodologies have been developed in Europe in the Externalities of Energy (ExternE) project series and follow-up activities. In this study, we aim at analyzing the main methodological developments over time from the 1990s until today with a focus on classical air pollution-induced human health damage costs. An up-to-date assessment including the latest European recommendations is also applied. Using a case from the energy sector, we identify major influencing parameters: differences in exposure modeling and related data lead to variations in damage costs of up to 21%; concerning risk assessment and monetary valuation, differences in assessing long-term exposure mortality risks together with assumptions on particle toxicity explain most of the observed changes in damage costs. These still debated influencing parameters deserve particular attention when damage costs are used to support environmental policy making.

  9. Challenges of Sanitary Compliance Related to Trade in Products of Animal Origin in Southern Africa.

    Science.gov (United States)

    Magwedere, Kudakwashe; Songabe, Tembile; Dziva, Francis

    2015-06-30

    Irrespective of the existence of potentially pathogenic organisms carried by animals, foods of animal origin remain the prime nutrition of humans world-wide. As such, food safety continues to be a global concern primarily to safeguard public health and to promote international trade. Application of integrated risk-based quality assurance procedures on-farm and at slaughterhouses plays a crucial role in controlling hazards associated with foods of animal origin. In the present paper we examine safety assurance systems and associated value chains for foods of animal origin based on historical audit results of some Southern African countries with thriving export trade in animal products, mainly to identify areas for improvement. Among the key deficiencies identified were: i) failure to keep pace with scientific advances related to the ever-changing food supply chain; ii) lack of effective national and regional intervention strategies to curtail pathogen transmission and evolution, notably the zoonotic Shiga toxin-producing Escherichia coli ; and iii) a lack of effective methods to reduce contamination of foods of wildlife origin. The introduction of foods of wildlife origin for domestic consumption and export markets seriously compounds already existing conflicts in legislation governing food supply and safety. This analysis identifies gaps required to improve the safety of foods of wildlife origin.

  10. Severe IgG4-Related Disease in a Young Child: A Diagnosis Challenge

    Directory of Open Access Journals (Sweden)

    Susana Corujeira

    2015-01-01

    Full Text Available Immunoglobulin G4-related disease (IgG4-RD is an increasingly recognized syndrome that can appear with multiple organ involvement, typically with tumor-like swelling, lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, and elevated serum IgG4 concentrations. We report the case of a 22-month-old female child with failure to thrive and recurrent respiratory tract infections since 8 months of age. Physical examination was normal except for pulmonary auscultation with bilateral crackles and wheezes. Laboratory tests revealed elevated erythrocyte sedimentation rate, and elevated serum IgG and IgG4 with polyclonal hypergammaglobulinemia. Thoracic CT and MRI showed multiple mediastinal lymphadenopathies and a nodular posterior mediastinal mass in right paratracheal location with bronchial compression. Initial fine needle aspiration biopsy was compatible with reactive lymphadenopathy but after clinical worsening a thoracoscopic partial resection of the mass was performed and tissue biopsy revealed lymphoplasmacytic infiltrate and increased number of IgG4-positive plasma cells and a ratio of IgG4/IgG positive cells above 40%. Glucocorticoids therapy was started with symptomatic improvement, reduction in the size of the mass, and decrease of serum IgG4 levels after 6 weeks. There are very few reports of IgG4-RD in children. Long-term follow-up is necessary to monitor relapses and additional organ involvement.

  11. Challenges of sanitary compliance related to trade in products of animal origin in Southern Africa

    Directory of Open Access Journals (Sweden)

    Kudakwashe Magwedere

    2015-06-01

    Full Text Available Irrespective of the existence of potentially pathogenic organisms carried by animals, foods of animal origin remain the prime nutrition of humans world-wide. As such, food safety continues to be a global concern primarily to safeguard public health and to promote international trade. Application of integrated risk-based quality assurance procedures on-farm and at slaughterhouses plays a crucial role in controlling hazards associated with foods of animal origin. In the present paper we examine safety assurance systems and associated value chains for foods of animal origin based on historical audit results of some Southern African countries with thriving export trade in animal products, mainly to identify areas for improvement. Among the key deficiencies identified were: i failure to keep pace with scientific advances related to the ever-changing food supply chain; ii lack of effective national and regional intervention strategies to curtail pathogen transmission and evolution, notably the zoonotic Shiga toxin-producing Escherichia coli; and iii a lack of effective methods to reduce contamination of foods of wildlife origin. The introduction of foods of wildlife origin for domestic consumption and export markets seriously compounds already existing conflicts in legislation governing food supply and safety. This analysis identifies gaps required to improve the safety of foods of wildlife origin.

  12. Challenges and Problems in the Kosovo Reality Related to Foreign Direct Investment

    Directory of Open Access Journals (Sweden)

    MSc. Nexhat Shkodra

    2015-06-01

    Full Text Available Economic development is a goal aspired by many countries of the world, Kosovo included. In attaining such goals, many countries face numerous difficulties. Amongst the most often taken paths by various countries is the attraction of foreign direct investments to the country. The term investment includes a wide range of human activities in engaging financial means into one of the areas: immoveable property, bonds and shares, manufacturing and service projects, scientific research, technological development, personnel education, etc. Different from internal investment which is engaged by domestic investors in their own territories, Foreign Direct Investment, the topic of our study, is a form of investment which generates revenues by a company in the country and an affiliate branch outside the investor’s seat. Foreign Direct Investments generate relations through the local company and its branches outside the country. Foreign Direct Investments (FDIs are considered to be a strength giving life to economic development of a country, and especially the developing countries. They have an important role to play in a long-term development of a country, and not only as a capital source, but also in increasing competitive abilities of the domestic economy, by technological transfers, strengthening infrastructure, increased productivity and generation of new employment opportunities.

  13. OPTIMIZATION OF SURFACE RESISTIVITY AND RELATIVE PERMITTIVITY OF SILICONE RUBBER FOR HIGH VOLTAGE APPLICATION USING RESPONSE SURFACE METHODOLOGY

    Directory of Open Access Journals (Sweden)

    N.N. Ali

    2017-06-01

    Full Text Available Silicone Rubber (SiR is considered as one of the most established insulator in High Voltage (HV industry. SiR possess a great function ability such as its lighter weight, great heat resistance and substantial electrical insulation properties. Dynamic research were performed all around the world in order to explore the unique insulating behavior of SiR but very little are done on the optimization of SiR in term of their processing parameters and formulation. In this work, four materials and processing factors were introduced; A: Alumina Trihydrate (ATH, B: Dicumyl-Peroxide (DCP, C: mixing speed and D: mixing time in order to analyze its contribution towards improving the surface resistivity and relative permittivity of SIR rubber. The factors range were set based on prior screening and are defined as; ATH (10 – 50 pphr, Dicumyl Peroxide (0.50 -1.50 pphr, speed of mixer (40 – 70 rpm and mixing period (5 – 10 mins which were then varied accordingly to produce an overall 19 samples of SiR blends. The testing results were analyzed using statistical Design of Experiment (DOE by applying two level full factorial from Design Expert Software (v10 to discover the inter-correlation between the factors studied and benefaction of each factor in improving both surface resistivity and relative permittivity responses of produced SiR blends. The model analysis on surface resistivity shows the coefficient of determination R2 value of 88.72% while the one for relative permittivity shows R2 value of 82.34 %. Combination of both dependent variables had yielded an optimization suggestion for SiR formulation and processing strategy of ATH: 50 pphr, DCP: 0.50 pphr, mixing speed: 70 rpm and mixing period: 10 mins with the desirability level of 0.835. The optimized formulation had resulted in the production of SiR blend with the characteristic of surface resistivity of 1.02039x10^14 Ω/sq and relative permittivity of 4.0231, respectively. In conclusion, it can be

  14. The LBB methodology application results performed on the safety related piping of NPP V-1 in Jaslovske Bohunice

    Energy Technology Data Exchange (ETDEWEB)

    Kupca, L.; Beno, P. [Nuclear Power Plants Research Institute, Trnava (Slovakia)

    1997-04-01

    A broad overview of the leak before break (LBB) application to the Slovakian V-1 nuclear power plant is presented in the paper. LBB was applied to the primary cooling circuit and surge lines of both WWER 440 type units, and also used to assess the integrity of safety related piping in the feed water and main steam systems. Experiments and calculations performed included analyses of stresses, material mechanical properties, corrosion, fatigue damage, stability of heavy component supports, water hammer, and leak rates. A list of analysis results and recommendations are included in the paper.

  15. Methodology for the development of a taxonomy and toolkit to evaluate health-related habits and lifestyle (eVITAL

    Directory of Open Access Journals (Sweden)

    Walsh Carolyn O

    2010-03-01

    Full Text Available Abstract Background Chronic diseases cause an ever-increasing percentage of morbidity and mortality, but many have modifiable risk factors. Many behaviors that predispose or protect an individual to chronic disease are interrelated, and therefore are best approached using an integrated model of health and the longevity paradigm, using years lived without disability as the endpoint. Findings This study used a 4-phase mixed qualitative design to create a taxonomy and related online toolkit for the evaluation of health-related habits. Core members of a working group conducted a literature review and created a framing document that defined relevant constructs. This document was revised, first by a working group and then by a series of multidisciplinary expert groups. The working group and expert panels also designed a systematic evaluation of health behaviors and risks, which was computerized and evaluated for feasibility. A demonstration study of the toolkit was performed in 11 healthy volunteers. Discussion In this protocol, we used forms of the community intelligence approach, including frame analysis, feasibility, and demonstration, to develop a clinical taxonomy and an online toolkit with standardized procedures for screening and evaluation of multiple domains of health, with a focus on longevity and the goal of integrating the toolkit into routine clinical practice. Trial Registration IMSERSO registry 200700012672

  16. [Methodological aspects of risk assessment of work related stress. Italian experience of R Karasek JCQ application, a multiphase approach].

    Science.gov (United States)

    Ferrario, M M; Cesana, G

    2009-01-01

    Due to a new legislation, the assessment of work stress has become compulsory in Italy for all the enterprise. Work stress is become a leading health problem in work settings all over Europe. The two major approaches, the expert-based direct observations and the measurements of the perceived job strain, are briefly introduced emphasizing on strengthens and weaknesses. Among the methods to assess perceived job stress, the Karasek's Job Content Questionnaire has been extensively used in Italy, and the available results support its use because reliable and able to pick up major constrictiveness at work. In addition, because it is now possible to have reference levels, comparisons are possible for either public or private enterprises. Acknowledging the complexity of carrying out reliable assessment of work stress, a multiphase approach is emphasised: first an analysis or current data can be used to estimate the levels of turnover, down-sizing, outsourcing, extra hours, shift work, sickness absenteeism, changes of job titles, work accidents and work-related diseases. At a second step, on groups of workers selected because recognised at risk at the first phase and on control groups, the JCQ can be used to assess workers stress perception. Finally, when constrain conditions emerge,further investigations are required, including: intervention of experts in work organisation analysis, clinical psychological examinations of selected workers, to separate between work-related and personal psychological problems and health consequences.

  17. Communicating Climate Uncertainties: Challenges and Opportunities Related to Spatial Scales, Extreme Events, and the Warming 'Hiatus'

    Science.gov (United States)

    Casola, J. H.; Huber, D.

    2013-12-01

    Many media, academic, government, and advocacy organizations have achieved sophistication in developing effective messages based on scientific information, and can quickly translate salient aspects of emerging climate research and evolving observations. However, there are several ways in which valid messages can be misconstrued by decision makers, leading them to inaccurate conclusions about the risks associated with climate impacts. Three cases will be discussed: 1) Issues of spatial scale in interpreting climate observations: Local climate observations may contradict summary statements about the effects of climate change on larger regional or global spatial scales. Effectively addressing these differences often requires communicators to understand local and regional climate drivers, and the distinction between a 'signal' associated with climate change and local climate 'noise.' Hydrological statistics in Missouri and California are shown to illustrate this case. 2) Issues of complexity related to extreme events: Climate change is typically invoked following a wide range of damaging meteorological events (e.g., heat waves, landfalling hurricanes, tornadoes), regardless of the strength of the relationship between anthropogenic climate change and the frequency or severity of that type of event. Examples are drawn from media coverage of several recent events, contrasting useful and potentially confusing word choices and frames. 3) Issues revolving around climate sensitivity: The so-called 'pause' or 'hiatus' in global warming has reverberated strongly through political and business discussions of climate change. Addressing the recent slowdown in warming yields an important opportunity to raise climate literacy in these communities. Attempts to use recent observations as a wedge between climate 'believers' and 'deniers' is likely to be counterproductive. Examples are drawn from Congressional testimony and media stories. All three cases illustrate ways that decision

  18. Preliminary Survey on TRY Forest Traits and Growth Index Relations - New Challenges

    Science.gov (United States)

    Lyubenova, Mariyana; Kattge, Jens; van Bodegom, Peter; Chikalanov, Alexandre; Popova, Silvia; Zlateva, Plamena; Peteva, Simona

    2016-04-01

    Forest ecosystems provide critical ecosystem goods and services, including food, fodder, water, shelter, nutrient cycling, and cultural and recreational value. Forests also store carbon, provide habitat for a wide range of species and help alleviate land degradation and desertification. Thus they have a potentially significant role to play in climate change adaptation planning through maintaining ecosystem services and providing livelihood options. Therefore the study of forest traits is such an important issue not just for individual countries but for the planet as a whole. We need to know what functional relations between forest traits exactly can express TRY data base and haw it will be significant for the global modeling and IPBES. The study of the biodiversity characteristics at all levels and functional links between them is extremely important for the selection of key indicators for assessing biodiversity and ecosystem services for sustainable natural capital control. By comparing the available information in tree data bases: TRY, ITR (International Tree Ring) and SP-PAM the 42 tree species are selected for the traits analyses. The dependence between location characteristics (latitude, longitude, altitude, annual precipitation, annual temperature and soil type) and forest traits (specific leaf area, leaf weight ratio, wood density and growth index) is studied by by multiply regression analyses (RDA) using the statistical software package Canoco 4.5. The Pearson correlation coefficient (measure of linear correlation), Kendal rank correlation coefficient (non parametric measure of statistical dependence) and Spearman correlation coefficient (monotonic function relationship between two variables) are calculated for each pair of variables (indexes) and species. After analysis of above mentioned correlation coefficients the dimensional linear regression models, multidimensional linear and nonlinear regression models and multidimensional neural networks models are

  19. Hard-to-heal diabetes-related foot ulcers: current challenges and future prospects

    Directory of Open Access Journals (Sweden)

    Nube V

    2016-11-01

    Full Text Available Vanessa Nube,1 Georgina Frank,1 Jessica White,1 Sarah Stubbs,1 Sara Nannery,2 Louise Pfrunder,2 Stephen M Twigg,3 Susan V McLennan4 1Department of Podiatry, Sydney Local Health District, Camperdown, NSW, Australia; 2Diabetes Centre High Risk Foot Service, Royal Prince Alfred Hospital, Camperdown, NSW, Australia; 3Discipline of Medicine, Sydney Medical School, University of Sydney, Camperdown, Sydney, NSW, Australia; 4Department of Endocrinology, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, Australia Abstract: Diabetes-related foot ulceration is a frequent cause for hospital admission and the leading cause of nontraumatic lower limb amputation, placing a high burden on the health system, patient, and their families. Considerable advances in treatments and the establishment of specialized services and teams have improved healing rates and reduced unnecessary amputations. However, amputation rates remain high in some areas, with unacceptable variations within countries yet to be resolved. Specific risk factors including infection, ischemia, ulcer size, depth, and duration as well as probing to bone (or osteomyelitis, location of ulcer, sensory loss, deformity (and high plantar pressure, advanced age, number of ulcers present, and renal disease are associated with poor outcome and delayed healing. To assist in prediction of difficult-to-heal ulcers, more than 13 classification systems have been developed. Ulcer depth (or size, infection, and ischemia are the most common risk factors identified. High-quality treatment protocols and guidelines exist to facilitate best practice in the standard of care. Under these conditions, 66%–77% of foot ulcers will heal. The remaining proportion represents a group unlikely to heal and who will live with a non-healing wound or undergo amputation. The authors have applied their experience of managing patients in this discussion of why some ulcers are harder to heal. The article explores the effects of

  20. A methodology for modelling energy-related human behaviour: Application to window opening behaviour in residential buildings

    DEFF Research Database (Denmark)

    Fabi, Valentina; Andersen, Rune Korsholm; Corgnati, Stefano P.

    2013-01-01

    that affect the results accuracy. Above all, the real energy performance can be affected by the actual behaviour of the building occupants. Thus, there are great benefits to be derived from improving models that simulate the behaviour of human beings within the context of engineered complex systems...... for modelling the human behaviour related to the control of indoor environment. The procedure is applied at models of occupants’ interactions with windows (opening and closing behaviour). Models of occupants’ window opening behaviour were inferred based on measurements and implemented in a simulation program......An energy simulation of a building is a mathematical representation of its physical behaviour considering all the thermal, lighting, acoustics aspects. However, a simulation cannot precisely replicate a real construction because all the simulations are based on a number of key assumptions...

  1. The methodological foundations of mutual integration of scientific knowledge in the field of physical education and sports and related sciences.

    Directory of Open Access Journals (Sweden)

    Kozina Zh.L.

    2012-02-01

    Full Text Available Possibilities of application of scientific knowledge in physical education and sport in contiguous scientific directions are considered. The advanced studies of leading specialists in area of physical education and sport are analysed. It is rotined that on the modern stage scientific developments in area of physical education and sport attained a level, when can be utillized in fundamental and applied sciences. Scientific researches in area of physical education and sport to the application scientific areas, such as pedagogics, psychology, design, programming et al are related. One of examples of mutual integration of scientific knowledge in area of physical education and sport there is theoretical conception of individualization of preparation of sportsmen.

  2. Social Responsibility of Partners of Labour Relations as a Factor of Rational Use of Labour Potential: Theoretical and Methodological Approach

    Directory of Open Access Journals (Sweden)

    Serikova Olga M.

    2013-11-01

    Full Text Available The article considers social responsibility of the employer and employee as a component of the socially responsible business. It identifies that social responsibility should be directed at such components as introduction of social programmes and improvement of labour conditions; establishment of the social dialogue; business self-perfection that is realised in responsibility for results of labour; increase of responsibility when performing work; use of ethic principles of relations with colleagues in the company policy; facilitation to realisation of ecological programmes, open presentation of information about activity of the organisation, influencing the society, economy and environment. Increase of social responsibility would facilitate increase of the level of use of the labour potential. Special attention is paid to ecological responsibility of business as a component of social responsibility, which becomes topical today under conditions of growth of the number of ecological problems.

  3. The varieties of contemplative experience: A mixed-methods study of meditation-related challenges in Western Buddhists.

    Directory of Open Access Journals (Sweden)

    Jared R Lindahl

    Full Text Available Buddhist-derived meditation practices are currently being employed as a popular form of health promotion. While meditation programs draw inspiration from Buddhist textual sources for the benefits of meditation, these sources also acknowledge a wide range of other effects beyond health-related outcomes. The Varieties of Contemplative Experience study investigates meditation-related experiences that are typically underreported, particularly experiences that are described as challenging, difficult, distressing, functionally impairing, and/or requiring additional support. A mixed-methods approach featured qualitative interviews with Western Buddhist meditation practitioners and experts in Theravāda, Zen, and Tibetan traditions. Interview questions probed meditation experiences and influencing factors, including interpretations and management strategies. A follow-up survey provided quantitative assessments of causality, impairment and other demographic and practice-related variables. The content-driven thematic analysis of interviews yielded a taxonomy of 59 meditation-related experiences across 7 domains: cognitive, perceptual, affective, somatic, conative, sense of self, and social. Even in cases where the phenomenology was similar across participants, interpretations of and responses to the experiences differed considerably. The associated valence ranged from very positive to very negative, and the associated level of distress and functional impairment ranged from minimal and transient to severe and enduring. In order to determine what factors may influence the valence, impact, and response to any given experience, the study also identified 26 categories of influencing factors across 4 domains: practitioner-level factors, practice-level factors, relationships, and health behaviors. By identifying a broader range of experiences associated with meditation, along with the factors that contribute to the presence and management of experiences reported

  4. Ethical challenges in nursing homes--staff's opinions and experiences with systematic ethics meetings with participation of residents' relatives.

    Science.gov (United States)

    Bollig, Georg; Schmidt, Gerda; Rosland, Jan Henrik; Heller, Andreas

    2015-12-01

    Many ethical problems exist in nursing homes. These include, for example, decision-making in end-of-life care, use of restraints and a lack of resources. The aim of the present study was to investigate nursing home staffs' opinions and experiences with ethical challenges and to find out which types of ethical challenges and dilemmas occur and are being discussed in nursing homes. The study used a two-tiered approach, using a questionnaire on ethical challenges and systematic ethics work, given to all employees of a Norwegian nursing home including nonmedical personnel, and a registration of systematic ethics discussions from an Austrian model of good clinical practice. Ninety-one per cent of the nursing home staff described ethical problems as a burden. Ninety per cent experienced ethical problems in their daily work. The top three ethical challenges reported by the nursing home staff were as follows: lack of resources (79%), end-of-life issues (39%) and coercion (33%). To improve systematic ethics work, most employees suggested ethics education (86%) and time for ethics discussion (82%). Of 33 documented ethics meetings from Austria during a 1-year period, 29 were prospective resident ethics meetings where decisions for a resident had to be made. Agreement about a solution was reached in all 29 cases, and this consensus was put into practice in all cases. Residents did not participate in the meetings, while relatives participated in a majority of case discussions. In many cases, the main topic was end-of-life care and life-prolonging treatment. Lack of resources, end-of-life issues and coercion were ethical challenges most often reported by nursing home staff. The staff would appreciate systematic ethics work to aid decision-making. Resident ethics meetings can help to reach consensus in decision-making for nursing home patients. In the future, residents' participation should be encouraged whenever possible. © 2015 The Authors. Scandinavian Journal of Caring

  5. Methodology of sustainability accounting

    Directory of Open Access Journals (Sweden)

    O.H. Sokil

    2017-03-01

    Full Text Available Modern challenges of the theory and methodology of accounting are realized through the formation and implementation of new concepts, the purpose of which is to meet the needs of users in standard and unique information. The development of a methodology for sustainability accounting is a key aspect of the management of an economic entity. The purpose of the article is to form the methodological bases of accounting for sustainable development and determine its goals, objectives, object, subject, methods, functions and key aspects. The author analyzes the theoretical bases of the definition and considers the components of the traditional accounting methodology. Generalized structural diagram of the methodology for accounting for sustainable development is offered in the article. The complex of methods and principles of sustainable development accounting for systematized and non-standard provisions has been systematized. The new system of theoretical and methodological provisions of accounting for sustainable development is justified in the context of determining its purpose, objective, subject, object, methods, functions and key aspects.

  6. Applications of landscape genetics in conservation biology: concepts and challenges

    Science.gov (United States)

    Gernot Segelbacher; Samuel A. Cushman; Bryan K. Epperson; Marie-Josee Fortin; Olivier Francois; Olivier J. Hardy; Rolf Holderegger; Stephanie Manel

    2010-01-01

    Landscape genetics plays an increasingly important role in the management and conservation of species. Here, we highlight some of the opportunities and challenges in using landscape genetic approaches in conservation biology. We first discuss challenges related to sampling design and introduce several recent methodological developments in landscape genetics (analyses...

  7. Impact of SPECT corrections on 3D-dosimetry for liver transarterial radioembolization using the patient relative calibration methodology

    Energy Technology Data Exchange (ETDEWEB)

    Pacilio, Massimiliano, E-mail: mpacilio@scamilloforlanini.rm.it; Basile, Chiara [Department of Medical Physics, Azienda Ospedaliera San Camillo Forlanini, Rome 00152 (Italy); Ferrari, Mahila; Botta, Francesca; Cremonesi, Marta [Department of Medical Physics, Istituto Europeo di Oncologia, Milan 20141 (Italy); Chiesa, Carlo [Department of Nuclear Medicine, Istituto Nazionale Tumori IRCCS Foundation, Milan 20133 (Italy); Lorenzon, Leda; Becci, Domenico [Postgraduate School of Medical Physics, “Sapienza” University of Rome, Rome 00185 (Italy); Mira, Marta [Post graduate Health Physics School, University of Milan, Milan 20122 (Italy); Torres, Leonel Alberto; Vergara Gil, Alex [Department of Nuclear Medicine, Clinical Research Division of the Center of Isotopes (DIC-CENTIS), Havana 11100 (Cuba); Coca Perez, Marco [Department of PET-CT and Nuclear Medicine, Imaging Center Medscan-Concepciòn, Concepciòn 4070061 (Chile); Ljungberg, Michael [Department of Medical Radiation Physics, University of Lund, Lund 22100 (Sweden); Pani, Roberto [Department of Medico-surgical Sciences and Biotecnologies, “Sapienza” University of Rome, Rome 00185 (Italy)

    2016-07-15

    Purpose: Many centers aim to plan liver transarterial radioembolization (TARE) with dosimetry, even without CT-based attenuation correction (AC), or with unoptimized scatter correction (SC) methods. This work investigates the impact of presence vs absence of such corrections, and limited spatial resolution, on 3D dosimetry for TARE. Methods: Three voxelized phantoms were derived from CT images of real patients with different body sizes. Simulations of {sup 99m}Tc-SPECT projections were performed with the SIMIND code, assuming three activity distributions in the liver: uniform, inside a “liver’s segment,” or distributing multiple uptaking nodules (“nonuniform liver”), with a tumoral liver/healthy parenchyma ratio of 5:1. Projection data were reconstructed by a commercial workstation, with OSEM protocol not specifically optimized for dosimetry (spatial resolution of 12.6 mm), with/without SC (optimized, or with parameters predefined by the manufacturer; dual energy window), and with/without AC. Activity in voxels was calculated by a relative calibration, assuming identical microspheres and {sup 99m}Tc-SPECT counts spatial distribution. 3D dose distributions were calculated by convolution with {sup 90}Y voxel S-values, assuming permanent trapping of microspheres. Cumulative dose-volume histograms in lesions and healthy parenchyma from different reconstructions were compared with those obtained from the reference biodistribution (the “gold standard,” GS), assessing differences for D95%, D70%, and D50% (i.e., minimum value of the absorbed dose to a percentage of the irradiated volume). γ tool analysis with tolerance of 3%/13 mm was used to evaluate the agreement between GS and simulated cases. The influence of deep-breathing was studied, blurring the reference biodistributions with a 3D anisotropic gaussian kernel, and performing the simulations once again. Results: Differences of the dosimetric indicators were noticeable in some cases, always negative

  8. On methodology

    DEFF Research Database (Denmark)

    Cheesman, Robin; Faraone, Roque

    2002-01-01

    This is an English version of the methodology chapter in the authors' book "El caso Berríos: Estudio sobre información errónea, desinformación y manipulación de la opinión pública".......This is an English version of the methodology chapter in the authors' book "El caso Berríos: Estudio sobre información errónea, desinformación y manipulación de la opinión pública"....

  9. Sex-related effects of an immune challenge on growth and begging behavior of barn swallow nestlings.

    Directory of Open Access Journals (Sweden)

    Andrea Romano

    Full Text Available Parent-offspring conflicts lead the offspring to evolve reliable signals of individual quality, including parasite burden, which may allow parents to adaptively modulate investment in the progeny. Sex-related variation in offspring reproductive value, however, may entail differential investment in sons and daughters. Here, we experimentally manipulated offspring condition in the barn swallow (Hirundo rustica by subjecting nestlings to an immune challenge (injection with bacterial lipopolysaccharide, LPS that simulates a bacterial infection, and assessed the effects on growth, feather quality, expression of morphological (gape coloration and behavioral (posture begging displays involved in parent-offspring communication, as well as on food allocation by parents. Compared to sham-injected controls, LPS-treated chicks suffered a depression of body mass and a reduction of palate color saturation. In addition, LPS treatment resulted in lower feather quality, with an increase in the occurrence of fault bars on wing feathers. The color of beak flanges, feather growth and the intensity of postural begging were affected by LPS treatment only in females, suggesting that chicks of either sex are differently susceptible to the immune challenge. However, irrespective of the effects of LPS, parents equally allocated food among control and challenged offspring both under normal food provisioning and after a short period of food deprivation of the chicks. These results indicate that bacterial infection and the associated immune response entail different costs to offspring of either sex, but a decrease in nestling conditions does not affect parental care allocation, possibly because the barn swallow adopts a brood-survival strategy. Finally, we showed that physiological stress induced by pathogens impairs plumage quality, a previously neglected major negative impact of bacterial infection which could severely affect fitness, particularly among long

  10. Oral Health-Related Quality of Life in the Elderly: A Review and Future Challenges in Thailand

    Directory of Open Access Journals (Sweden)

    Supawadee Naorungroj, DDS, Ph.D.

    2015-09-01

    Full Text Available Oral health related quality of life (OHRQoL is a multidimensional concept that measures perceptions of oral health and the consequences of oral conditions at individual and population levels. Poor oral conditions are associated with a deteriorating quality of life (QoL through functional and psychosocial impacts. As the elder population is growing worldwide and the prevalence of oral diseases among older adults remains high, more at- tention needs to be paid to oral health conditions as well as impacts on QoL. However, there are few population studies regarding OHRQoL in older Thai adults. Apparently, there are several challenges facing the assessment and improvement of the OHRQoL of this aging population. First, effort towards the standardization of instruments and validation of translated instruments is needed. Secondly, a multidisciplinary team, composed of health care providers, dental professionals, and policy makers has to be established. Finally, a holistic oral health care concept must be emphasized in dental educational programs and training. This review presents an overview of OHRQoL and its importance to the elderly and discusses future challenges to this group of the population in Thailand.

  11. Expression Analysis of Immune Related Genes Identified from the Coelomocytes of Sea Cucumber (Apostichopus japonicus in Response to LPS Challenge

    Directory of Open Access Journals (Sweden)

    Ying Dong

    2014-10-01

    Full Text Available The sea cucumber (Apostichopus japonicus occupies a basal position during the evolution of deuterostomes and is also an important aquaculture species. In order to identify more immune effectors, transcriptome sequencing of A. japonicus coelomocytes in response to lipopolysaccharide (LPS challenge was performed using the Illumina HiSeq™ 2000 platform. One hundred and seven differentially expressed genes were selected and divided into four functional categories including pathogen recognition (25 genes, reorganization of cytoskeleton (27 genes, inflammation (41 genes and apoptosis (14 genes. They were analyzed to elucidate the mechanisms of host-pathogen interactions and downstream signaling transduction. Quantitative real-time polymerase chain reactions (qRT-PCRs of 10 representative genes validated the accuracy and reliability of RNA sequencing results with the correlation coefficients from 0.88 to 0.98 and p-value <0.05. Expression analysis of immune-related genes after LPS challenge will be useful in understanding the immune response mechanisms of A. japonicus against pathogen invasion and developing strategies for resistant markers selection.

  12. Normative Bias and Adaptive Challenges: A Relational Approach to Coalitional Psychology and a Critique of Terror Management Theory

    Directory of Open Access Journals (Sweden)

    Carlos David Navarrete

    2005-01-01

    Full Text Available Adherence to ingroup ideology increases after exposure to death-related stimuli, a reaction that proponents of terror management theory (TMT explain as a psychological defense against the uniquely human existential fear of death. We argue that existential concerns are not the relevant issue; rather, such concepts can be subsumed under a larger category of adaptive challenges that prime coalitional thinking. We suggest that increases in adherence to ingroup ideology in response to adaptive challenges are manifestations of normative mental representations emanating from psychological systems designed to enhance coordination and membership in social groups. In providing an alternative to TMT, we (1 explain why the theory is inconsistent with contemporary evolutionary biology, (2 demonstrate that mortality-salience does not have the unique evocative powers ascribed to it by TMT advocates, and (3 discuss our approach to coalitional psychology, a framework consistent with modern evolutionary theory and informed by a broad understanding of cultural variation, can be employed to help account for both the corpus of results in TMT research and the growing body of findings inconsistent with TMT's predictions.

  13. Federalism, intergovernmental relations, and the challenge of the medically uninsurable: a retrospective on high risk pools in the states.

    Science.gov (United States)

    Plein, L Christopher

    2010-01-01

    While relatively overlooked in health policy research and analysis, state high risk insurance pools play a notable role in contemporary health policy arrangements. Also know as State Comprehensive Health Insurance Plans, high-risk pools emerged in the late 1970s as states began to grapple with the challenges of the medically uninsured. Today, thirty-five states operate these programs. To further our understanding of health and human services administration, it is important to examine these plans, especially in context of intergovernmental health policy in the United States. This analysis provides an overview of high risk pool evolution and gives attention to forces that have shaped their development, such as model legislation, funding arrangements, and increasing federal-level interest in their use as platforms to advance national policy initiatives.

  14. Development of methodologies for optimization of surveillance testing and maintenance of safety related equipment at NPPs. Report of a research coordination meeting. Working material

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-09-01

    This report summarizes the results of the first meeting of the Coordinated Research Programme (CRP) on Development of Methodologies for Optimization of Surveillance Testing and Maintenance of Safety Related Equipment at NPPs, held at the Agency Headquarters in Vienna, from 16 to 20 December 1996. The purpose of this Research Coordination Meeting (RCM) was that all Chief Scientific Investigators of the groups participating in the CRP presented an outline of their proposed research projects. Additionally, the participants discussed the objective, scope, work plan and information channels of the CRP in detail. Based on these presentations and discussions, the entire project plan was updated, completed and included in this report. This report represents a common agreed project work plan for the CRP. Refs, figs, tabs.

  15. Surface design methodologychallenge the steel

    International Nuclear Information System (INIS)

    Bergman, M; Rosen, B-G; Eriksson, L; Anderberg, C

    2014-01-01

    The way a product or material is experienced by its user could be different depending on the scenario. It is also well known that different materials and surfaces are used for different purposes. When optimizing materials and surface roughness for a certain something with the intention to improve a product, it is important to obtain not only the physical requirements, but also the user experience and expectations. Laws and requirements of the materials and the surface function, but also the conservative way of thinking about materials and colours characterize the design of medical equipment. The purpose of this paper is to link the technical- and customer requirements of current materials and surface textures in medical environments. By focusing on parts of the theory of Kansei Engineering, improvements of the companys' products are possible. The idea is to find correlations between desired experience or ''feeling'' for a product, -customer requirements, functional requirements, and product geometrical properties -design parameters, to be implemented on new improved products. To be able to find new materials with the same (or better) technical requirements but a higher level of user stimulation, the current material (stainless steel) and its surface (brushed textures) was used as a reference. The usage of focus groups of experts at the manufacturer lead to a selection of twelve possible new materials for investigation in the project. In collaboration with the topical company for this project, three new materials that fulfil the requirements -easy to clean and anti-bacterial came to be in focus for further investigation in regard to a new design of a washer-disinfector for medical equipment using the Kansei based Clean ability approach CAA

  16. Documentary Linguistics: Methodological Challenges and Innovatory Responses

    Science.gov (United States)

    Thieberger, Nick

    2016-01-01

    Seeing the present situation, I think that, at the very least, it behooves us as scientists and as human beings to work responsibly both for the future of our science and for the future of our languages, not so much for reward according to the fashion of the day, but for the sake of posterity. What we need to do now stares us in the face. If we do…

  17. Methodological Challenges for Collaborative Learning Research

    Science.gov (United States)

    Strijbos, Jan-Willem; Fischer, Frank

    2007-01-01

    Research on collaborative learning, both face-to-face and computer-supported, has thrived in the past 10 years. The studies range from outcome-oriented (individual and group learning) to process-oriented (impact of interaction on learning processes, motivation and organisation of collaboration) to mixed studies. Collaborative learning research is…

  18. Surface design methodology - challenge the steel

    Science.gov (United States)

    Bergman, M.; Rosen, B.-G.; Eriksson, L.; Anderberg, C.

    2014-03-01

    The way a product or material is experienced by its user could be different depending on the scenario. It is also well known that different materials and surfaces are used for different purposes. When optimizing materials and surface roughness for a certain something with the intention to improve a product, it is important to obtain not only the physical requirements, but also the user experience and expectations. Laws and requirements of the materials and the surface function, but also the conservative way of thinking about materials and colours characterize the design of medical equipment. The purpose of this paper is to link the technical- and customer requirements of current materials and surface textures in medical environments. By focusing on parts of the theory of Kansei Engineering, improvements of the companys' products are possible. The idea is to find correlations between desired experience or "feeling" for a product, -customer requirements, functional requirements, and product geometrical properties -design parameters, to be implemented on new improved products. To be able to find new materials with the same (or better) technical requirements but a higher level of user stimulation, the current material (stainless steel) and its surface (brushed textures) was used as a reference. The usage of focus groups of experts at the manufacturer lead to a selection of twelve possible new materials for investigation in the project. In collaboration with the topical company for this project, three new materials that fulfil the requirements -easy to clean and anti-bacterial came to be in focus for further investigation in regard to a new design of a washer-disinfector for medical equipment using the Kansei based Clean ability approach CAA.

  19. Methodological Challenges in Measuring Child Maltreatment

    Science.gov (United States)

    Fallon, Barbara; Trocme, Nico; Fluke, John; MacLaurin, Bruce; Tonmyr, Lil; Yuan, Ying-Ying

    2010-01-01

    Objective: This article reviewed the different surveillance systems used to monitor the extent of reported child maltreatment in North America. Methods: Key measurement and definitional differences between the surveillance systems are detailed and their potential impact on the measurement of the rate of victimization. The infrastructure…

  20. Is the amount of exposure to aggressive challenging behaviour related to staff work-related well-being in intellectual disability services? Evidence from a clustered research design.

    Science.gov (United States)

    Flynn, Samantha; Hastings, Richard P; Gillespie, David; McNamara, Rachel; Randell, Elizabeth

    2018-04-17

    Previous research has demonstrated an association between aggressive challenging behaviour (CB) and reductions in work-related well-being for intellectual disability (ID) support staff. Much of this research has used subjective measures of CB. To examine whether exposure to aggressive CB is associated with reduced work-related well-being in staff working in ID residential settings across the UK. A cross-sectional analysis was undertaken as part of a randomised trial; 186 staff from 100 settings completed questionnaires on their CB self-efficacy, empathy, positive work motivation, and burnout. Objective measures of aggressive CB in the preceding 16 weeks were collected from each setting. There was little association between staff exposure to aggressive CB and work-related well-being. Clustering effects were found for emotional exhaustion and positive work motivation, suggesting these variables are more likely to be influenced by the environment in which staff work. The level of clustering may be key to understanding how to support staff working in ID residential settings, and should be explored further. Longitudinal data, and studies including a comparison of staff working in ID services without aggressive CB exposure are needed to fully understand any association between aggressive CB and staff well-being. Copyright © 2018 Elsevier Ltd. All rights reserved.

  1. Engaging Secondary School Students in Food-Related Citizenship: Achievements and Challenges of A Multi-Component Programme

    Directory of Open Access Journals (Sweden)

    Mat Jones

    2012-05-01

    Full Text Available Global food security and sustainability, animal welfare, dietary health, and socially just relations of food production have become prominent societal issues. They are of particular concern for young people as their lives progress towards becoming independent consumers and citizens with the capacity to shape food systems of the future. This paper examined the role of the Food for Life Partnership programme in promoting young people’s engagement with food-related citizenship education in secondary schools. The research consisted of a two stage study of 24 English schools. We surveyed experiences and attitudes of students and staff, and recorded programme activities. The results presented a mixed picture. Staff reports and monitoring evidence showed much successful implementation of programme activities across the whole school. However, there was less evidence of positive student behavioral change. Amongst a range of possibilities to account for the findings, one explanation is the organizational challenges of delivering a complex and ambitious programme in the secondary school setting. This suggests the need to develop food citizenship programmes that combine long term institutional reforms alongside focused interventions with specific groups of students. It also highlights the case for ensuring a place for food related citizenship on the educational policy agenda.

  2. From seduction to sexism: Feminists challenge the ethics of therapist-client sexual relations in 1970s america.

    Science.gov (United States)

    Kim, Susanna; Rutherford, Alexandra

    2015-08-01

    Before the 1970s, psychologists and other mental health professionals who had sex with their patients committed no ethical violations. Indeed, the line between seduction and sexual exploitation in the therapy hour was extremely blurry to patients and therapists alike. This article is about how that changed. We focus on feminist psychologists' efforts, through the American Psychological Association Task Force on Sex Bias and Sex Role Stereotyping in Psychotherapeutic Practice, to document and reduce sexism in psychotherapy, including that involving therapist-client sexual relations. We contextualize these efforts within the larger feminist critique of the psy-disciplines that began in the late 1960s, highlighting how psychologists used several feminist strategies to recast seduction as sexism and revise the profession's ethical standards to specifically state that sexual intimacies with clients are unethical. As an example of a feminist intervention into psychology's-and society's-extant gender ideologies, this process highlights the mutually reinforcing entanglements of psychology and feminism, both methodologically and politically. (c) 2015 APA, all rights reserved).

  3. Methodological guidelines

    International Nuclear Information System (INIS)

    Halsnaes, K.; Callaway, J.M.; Meyer, H.J.

    1999-01-01

    The guideline document establishes a general overview of the main components of climate change mitigation assessment. This includes an outline of key economic concepts, scenario structure, common assumptions, modelling tools and country study assumptions. The guidelines are supported by Handbook Reports that contain more detailed specifications of calculation standards, input assumptions and available tools. The major objectives of the project have been provided a methodology, an implementing framework and a reporting system which countries can follow in meeting their future reporting obligations under the FCCC and for GEF enabling activities. The project builds upon the methodology development and application in the UNEP National Abatement Coasting Studies (UNEP, 1994a). The various elements provide countries with a road map for conducting climate change mitigation studies and submitting national reports as required by the FCCC. (au) 121 refs

  4. Methodological guidelines

    Energy Technology Data Exchange (ETDEWEB)

    Halsnaes, K.; Callaway, J.M.; Meyer, H.J.

    1999-04-01

    The guideline document establishes a general overview of the main components of climate change mitigation assessment. This includes an outline of key economic concepts, scenario structure, common assumptions, modelling tools and country study assumptions. The guidelines are supported by Handbook Reports that contain more detailed specifications of calculation standards, input assumptions and available tools. The major objectives of the project have been provided a methodology, an implementing framework and a reporting system which countries can follow in meeting their future reporting obligations under the FCCC and for GEF enabling activities. The project builds upon the methodology development and application in the UNEP National Abatement Coasting Studies (UNEP, 1994a). The various elements provide countries with a road map for conducting climate change mitigation studies and submitting national reports as required by the FCCC. (au) 121 refs.

  5. Challenges of local water governance

    DEFF Research Database (Denmark)

    Munk Ravnborg, Helle; Bustamante, Rocio; Cissé, Abdoulaye

    2012-01-01

    This article presents the results of comprehensive inventories made of water-related conflict and cooperation occurring in five districts in Africa, Asia and Latin America between 1997 and 2007. Following a description of the conceptual and methodological framework developed for undertaking...... these inventories, the article documents the extent, nature and intensity of water-related conflict and cooperation in the five districts. The article concludes by identifying three challenges relating to the magnitude, complexity and invisibility of local-level conflict and cooperation about water, which efforts...... to improve local water governance would have to address....

  6. Methodology of teaching and new challenges in the training of professionals in the area of industrial radiology; Metodologia de ensino e novos desafios na formação de profissionais na área de radiologia industrial

    Energy Technology Data Exchange (ETDEWEB)

    Lima, C.M. Araujo, E-mail: c.araujo@maximindustrial.com.br [MAXIM Industrial, Rio de Janeiro, RJ (Brazil); Pelegrineli, S.Q. [Faculdade Casa Branca (FACAB), SP (Brazil); Lima, A.R. [Comissão Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil)

    2017-07-01

    One of the main causes of radiological accidents is the lack of knowledge in radiological protection of workers. In order to meet the needs of professionals in radiology techniques in training in industrial radiology and radiological protection, the Training Course in Industrial Radiology was created in 2009 by MAXIM, in partnership with the Casa Branca Faculty. The objective is to present the structure and methodology of teaching used in this course to reach the objectives of training professionals with solid knowledge in industrial radiology, as well as to mention the challenges of this training. For the elaboration of the study, a statistical data base and theoretical analysis of the teaching structure of the course was used. Professional training in industrial radiology is subdivided into basic, specific, practical and complementary modules, totaling a workload of 360 hours. It is noted that most of the professionals trained come from the great urban centers of the country, favoring employability in the port terminals and industries that are located in these regions. It is concluded, therefore, that it is necessary and of great importance for the growing industrial market, the formation of new professionals, mainly in cities of the interior.

  7. Comparative Studies: historical, epistemological and methodological notes

    Directory of Open Access Journals (Sweden)

    Juan Ignacio Piovani

    2017-09-01

    Full Text Available In this article some historical, epistemological and methodological issues related to comparative studies in the social sciences are addressed, with specific reference to the field of education. The starting point is a discussion of the meaning of comparison, its logical structure and its presence in science and in everyday life. It follows the presentation and critical appraisal of the perspectives regarding comparison as a scientific method. It is argued that, even rejecting this restrictive meaning of comparison as a method, there is some consensus on the specificity of comparative studies within the social sciences. And in relation to them, the article address in more detail those studies that can be defined as trans-contextual (cross-national and cross-cultural, with emphasis on the main methodological and technical challenges they face. The socio-historical comparative perspective, which has gained importance in recent years in the field of education, is also discussed.

  8. MIRD methodology

    International Nuclear Information System (INIS)

    Rojo, Ana M.; Gomez Parada, Ines

    2004-01-01

    The MIRD (Medical Internal Radiation Dose) system was established by the Society of Nuclear Medicine of USA in 1960 to assist the medical community in the estimation of the dose in organs and tissues due to the incorporation of radioactive materials. Since then, 'MIRD Dose Estimate Report' (from the 1 to 12) and 'Pamphlets', of great utility for the dose calculations, were published. The MIRD system was planned essentially for the calculation of doses received by the patients during nuclear medicine diagnostic procedures. The MIRD methodology for the absorbed doses calculations in different tissues is explained

  9. Methodology of radionuclides dis incorporation in people related to nuclear and radiological accidents; Metodologia de desincorporacion de radinuclidos en personas relacionadas con accidentes nucleares y radiologicos

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez F, E. A.

    2014-07-01

    In this paper a classification of the radiological and nuclear accidents is presented, describing which the activities are, where they have occurred, their incidence and the learned lessons in these successes. The radiological accidents in which radioactive materials intervene can occur anywhere, and they are related to no controlled dangerous sources (abandoned, lost, stolen, or found sources), improper use of dangerous industrial and medical sources, exposition and contamination of people in general by an unknown origin, serious over expositions, menaces and willful misconduct, emergencies during transportation of radioactive material. A person can receive a dose of radiation from an external source, because of radioactive material placed on skin or on equipment, or because of ingestion or inhalation of radiological particles. The ingestion or the inhalation of radioactive material can cause an internal dose to the whole body or to a specific organ during a period of time. That is why a description of the processes of incorporation, the stages of incorporation and a description of the biokinetic models are also realized to understand the ingestion, transference and the excretion of the radioactive elements. In order to offer help to a victim of internal contamination, the dosimetric and medical diagnosis is very important. The most important techniques of dosimetric diagnosis are the dosimetry in vivo (cytogenetics and the counting in vivo of the whole body) and the bioassays. These techniques allow obtain data such as the radionuclide, the target organ, the absorbed dose, etc. At the same time, the doctor in charge must be attentive to the patients symptoms and their manifestation time, since they are an indicator, first, the patient suffered an irradiation, and second, of the range esteem of the received radiation dose. These are the parameters that are useful as criterion to decide if a person has to receive some treatment and select the methodologies that

  10. Dificultades en los métodos de estudio de exposiciones ambientales y defectos del tubo neural Methodological challenges to assess environmental exposures related to neural tube defects

    Directory of Open Access Journals (Sweden)

    Víctor Hugo Borja-Aburto

    1999-11-01

    Full Text Available Objetivo. Discutir las actitudes en la evaluación de las exposiciones ambientales como factores de riesgo para defectos de riesgo del tubo neural, al tiempo que se presentan los principales factores estudiados hasta la fecha. Resultados. Las exposiciones ambientales se citan muy a menudo como causa de malformaciones congénitas; sin embargo, ha sido difícil establecer esta asociación en los estudios de poblaciones humanas, debido a problemas en su diseño y conducción. Lo anterior es particularmente marcado en el caso del estudio de los defectos del cierre del tubo neural (DTN, que es una de las principales malformaciones y que incluye anencefalia, espina bífida y encefalocele, y su asociación con exposiciones ambientales. Las dificultades en los métodos surgen de: a la medida de frecuencia para realizar comparaciones espacio-temporales; b la clasificación y heterogeneidad de las malformaciones; c la consideración de los factores relacionados con la madre, el padre y el producto, de manera conjunta, y d la evaluación de las exposiciones ambientales. Conclusiones. Hipotéticamente las exposiciones ambientales tanto del padre como de la madre pueden producir daño genético antes y/o después de la concepción por la acción directa sobre el embrión o sobre el complejo fetoplacentario, de tal manera que en la evaluación de exposiciones ambientales: a deben tomarse en cuenta las exposiciones maternas y paternas; b debe considerarse el periodo crítico de exposición, esto es, tres meses anteriores a la concepción para el padre y un mes alrededor de la concepción para la madre; c en la medida de lo posible, la evaluación de la exposición deberá ser cuantitativa, evitando clasificar a los grupos únicamente como expuestos y no expuestos, y d es recomendable emplear marcadores biológicos de exposición siempre que sea posible, así como utilizar marcadores biológicos que permitan clasificar a la población en grupos con distinta susceptibilidad genética.Objective. To discuss the attitudes in the assessment of environmental exposures as risk factors associated with neural tube defects, and to present the main risk factors studied to date. Results. Environmental exposures have been suggested to have a roll in the genesis of birth defects. However, studies conducted in human populations have found difficulties in the design and conduction to show such an association for neural tube defects (anencephaly, espina bifida and encefalocele because of problems raised from: a the frequency measures used to compare time trends and communities, b the classification of heterogeneous malformations, c the inclusion of maternal, paternal and fetal factors as an integrated process and, d the assessment of environmental exposures. Conclusions. Hypothetically both maternal and paternal environmental exposures can produce damage before and after conception by direct action on the embryo and the fetus-placenta complex. Therefore, in the assessment of environmental exposures we need to take into account: a both paternal and maternal exposures; b the critical exposure period, three months before conception for paternal exposures and one month around the conceptional period for maternal exposures; c quantitatively evaluate environmental exposures when possible, avoiding a dichotomous classification; d the use of biological markers of exposure is highly recommended as well as markers of genetic susceptibility.

  11. Opportunities and challenges related to the development of small modular reactors in mines in the Northern Territories of Canada

    Energy Technology Data Exchange (ETDEWEB)

    Sam-Aggrey, H., E-mail: godfree17@hotmail.com [Canadian Nuclear Laboratories, Chalk River, Ontario (Canada)

    2016-06-15

    Small modular reactors (SMRs) are being touted as safer, more cost effective, and more flexible than traditional nuclear power plants. Consequently, it has been argued that SMR technology is pivotal to the revitalization of the nuclear industry at the national and global levels. Drawing mainly on previously published literature, this paper explores the opportunities and challenges related to the deployment of SMRs in the northern territories of Canada. The paper examines the potential role of SMRs in providing an opportunity for remote mines in northern Canada to reduce their vulnerability and dependence on costly, high-carbon diesel fuel. The paper also outlines and discusses some of the potential socio-economic barriers that could impede the successful introduction of SMRs in the territories. These issues include: economic factors (such as the price of primary minerals and economics of mineral exploration, and the cost of SMR deployment), the lack of infrastructure in the territories to support mining developments, and the issues pertaining to the social acceptance of nuclear power generation. (author)

  12. THE CHALLENGES OF CORPORATE GOVERNANCE AND AUDIT IN RELATION TO FINANCIAL PERFORMANCE – TRENDS, LIMITATIONS AND DIRECTIONS TO FOLLOW

    Directory of Open Access Journals (Sweden)

    Alexandra Narcisa CIOBAN (LUCAN

    2016-12-01

    Full Text Available Through this paper we propose to identify and present the latest trends in valuing the corporate governance and audit features in relation to the company performance, measured in financial terms. Our research is qualitative, as it covers a wide range of approache from the perspective of academics and practitioners in the field. In this regard, we consulted the most important resources in the world scientific electronic documentation, such as: Thomson Reuters Web of Science, SpringerLink platform, PROQUEST Central, Oxford Journals, Emerald Journals and other research platforms. The contribution of this research it is valuable both for researchers in the area of financial accounting and practitioners, and aims to identify the recent challenges of the corporate governance and audit in influencing the financial performance of major companies around the world. We analyzed a variety of scientific publications on this subject, more than 70 empirical studies conducted in the US, China, Russia, Japan, India, Malaysia, the Arab countries, UK, Germany, Spain, Romania, etc. After having conducted the research, we carried out a platform with representative variables for corporate governance, audit and financial performance which will serve for future studies in the field. This will facilitate the researchers’ choice for building econometric analysis models since we also surprised existing limitations.

  13. An assessment of international trade related to bioenergy use in Austria—Methodological aspects, recent developments and the relevance of indirect trade

    International Nuclear Information System (INIS)

    Kalt, Gerald; Kranzl, Lukas

    2012-01-01

    Increasing international biomass trade for energy and concerns about sustainability of globally traded biomass have raised interest in assessments of cross-border trade related to bioenergy. Within this paper, approaches to overcome methodological difficulties related to biomass trade are proposed and applied for the case of Austria. Biomass currently has a share of 15.5% in Austria’s primary energy consumption of 1354 PJ (2009). According to energy statistics, the rate of self-sufficiency with biomass for energy (defined as the ratio of domestic production to inland consumption, with both imports and exports taken into account) is 91%. However, feedstock imports for transport fuel production and indirect imports of wood-based fuels (wood processing residues and waste liquor of the paper industry originating from imported wood) are not taken into account in energy statistics, but prove to be of some significance. Imports of agricultural commodities to the amount of 9.7 PJ can be attributed to domestic biofuel production, and indirect imports of wood-based fuels, account for 31 PJ. With these import streams taken into account, the share of domestic fuels in bioenergy use is only 67%, rather than 84%, as official energy statistics suggest. On the other hand, Austria is exporting more than 50% of its production of sawnwood, panelboard and paper products. - Highlights: ► We investigate biomass cross-border trade related to bioenergy use in Austria. ► International biomass trade for energy has increased significantly in recent years. ► A flow wood diagram is derived to identify indirect trade streams of wood fuels. ► Biofuel feedstock imports are about as important as direct biofuel imports. ► 33% of bioenergy in Austria originate from imported biomass (2009).

  14. Elderly Patients with Dementia-Related Symptoms of Severe Agitation and Aggression: Consensus Statement on Treatment Options, Clinical Trials Methodology, and Policy

    Science.gov (United States)

    Salzman, C; Jeste, D; Meyer, RE; Cohen-Mansfield, J; Cummings, J; Grossberg, G; Jarvik, L; Kraemer, H; Lebowitz, B; Maslow, K; Pollock, B; Raskind, M; Schultz, S; Wang, P; Zito, JM; Zubenko, GS

    2009-01-01

    Atypical antipsychotic drugs have been used off-label in clinical practice for treatment of serious dementia-associated agitation and aggression. Following reports of cerebrovascular adverse events associated with the use of atypical antipsychotic in elderly patients with dementia, the FDA issued black box warnings for several atypical antipsychotics, titled “Cerebrovascular Adverse Events, including Stroke, in Elderly Patients with Dementia.” Subsequently, the FDA initiated a meta-analysis of safety data from 17 registration trials across six antipsychotic drugs (five atypical antipsychotics and haloperidol). In 2005, the Agency issued a black box warning regarding increased risk of mortality associated with the use of atypical antipsychotic drugs in this patient population. Geriatric mental health experts participating in a 2006 consensus conference reviewed evidence on the safety and efficacy of antipsychotics, as well as nonpharmacologic approaches, in treating dementia-related symptoms of agitation and aggression. They concluded that, while problems in clinical trials design may have been one of the contributors to the failure to find a signal of drug efficacy, the findings related to drug safety should be taken seriously by clinicians in assessing the potential risks and benefits of treatment in a frail population, and in advising families about treatment. Information provided to patients and family members should be documented in the patient’s chart. Drugs should be used only when non-pharmacologic approaches have failed to adequately control behavioral disruption. Participants also agreed that that there is a need for an FDA-approved medication for the treatment of severe, persistent or recurrent dementia-related symptoms of agitation and aggression (even in the absence of psychosis), that are unresponsive to nonpharmacologic intervention. The authors have outlined methodological enhancements to better evaluate treatment approaches in future

  15. Tolerance to spatial-relational transformations in unfamiliar faces: A further challenge to a configural processing account of identity recognition.

    Science.gov (United States)

    Lorenzino, Martina; Caminati, Martina; Caudek, Corrado

    2018-05-25

    One of the most important questions in face perception research is to understand what information is extracted from a face in order to recognize its identity. Recognition of facial identity has been attributed to a special sensitivity to "configural" information. However, recent studies have challenged the configural account by showing that participants are poor in discriminating variations of metric distances among facial features, especially for familiar as opposed to unfamiliar faces, whereas a configural account predicts the opposite. We aimed to extend these previous results by examining classes of unfamiliar faces with which we have different levels of expertise. We hypothesized an inverse relation between sensitivity to configural information and expertise with a given class of faces, but only for neutral expressions. By first matching perceptual discriminability, we measured tolerance to subtle configural transformations with same-race (SR) versus other-race (OR) faces, and with upright versus upside-down faces. Consistently with our predictions, we found a lower sensitivity to at-threshold configural changes for SR compared to OR faces. We also found that, for our stimuli, the face inversion effect disappeared for neutral but not for emotional faces - a result that can also be attributed to a lower sensitivity to configural transformations for faces presented in a more familiar orientation. The present findings question a purely configural account of face processing and suggest that the role of spatial-relational information in face processing varies according to the functional demands of the task and to the characteristics of the stimuli. Copyright © 2018 Elsevier B.V. All rights reserved.

  16. The challenge for genetic epidemiologists: how to analyze large numbers of SNPs in relation to complex diseases.

    Science.gov (United States)

    Heidema, A Geert; Boer, Jolanda M A; Nagelkerke, Nico; Mariman, Edwin C M; van der A, Daphne L; Feskens, Edith J M

    2006-04-21

    Genetic epidemiologists have taken the challenge to identify genetic polymorphisms involved in the development of diseases. Many have collected data on large numbers of genetic markers but are not familiar with available methods to assess their association with complex diseases. Statistical methods have been developed for analyzing the relation between large numbers of genetic and environmental predictors to disease or disease-related variables in genetic association studies. In this commentary we discuss logistic regression analysis, neural networks, including the parameter decreasing method (PDM) and genetic programming optimized neural networks (GPNN) and several non-parametric methods, which include the set association approach, combinatorial partitioning method (CPM), restricted partitioning method (RPM), multifactor dimensionality reduction (MDR) method and the random forests approach. The relative strengths and weaknesses of these methods are highlighted. Logistic regression and neural networks can handle only a limited number of predictor variables, depending on the number of observations in the dataset. Therefore, they are less useful than the non-parametric methods to approach association studies with large numbers of predictor variables. GPNN on the other hand may be a useful approach to select and model important predictors, but its performance to select the important effects in the presence of large numbers of predictors needs to be examined. Both the set association approach and random forests approach are able to handle a large number of predictors and are useful in reducing these predictors to a subset of predictors with an important contribution to disease. The combinatorial methods give more insight in combination patterns for sets of genetic and/or environmental predictor variables that may be related to the outcome variable. As the non-parametric methods have different strengths and weaknesses we conclude that to approach genetic association

  17. Evaluation of optimum conditions for pachyman encapsulated in poly(D,L-lactic acid nanospheres by response surface methodology and results of a related in vitro study

    Directory of Open Access Journals (Sweden)

    Zheng S

    2016-09-01

    Full Text Available Sisi Zheng, Li Luo, Ruonan Bo, Zhenguang Liu, Jie Xing, Yale Niu, Yuanliang Hu, Jiaguo Liu, Deyun Wang Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China Abstract: This study aimed to optimize the preparation conditions of pachyman (PHY-loaded poly(D,L-lactic acid (PLA (PHYP nanospheres by response surface methodology, explore their characteristics, and assess their effects on splenic lymphocytes. Double emulsion solvent evaporation was used to synthesize PHYP nanospheres, and the optimal preparation conditions were identified as a concentration of poloxamer 188 (F68 (w/v of 0.33%, a concentration of PLA of 30 mg/mL, and a ratio of PLA to drug (w/w of 10.25:1 required to reach the highest encapsulation efficiency, which was calculated to be 59.10%. PHYP had a spherical shape with a smooth surface and uniform size and an evident effect of sustained release and relative stability. Splenic lymphocytes are crucial and multifunctional cells in the immune system, and their immunological properties could be enhanced significantly by PHYP treatment. This study confirmed that PHY encapsulated in PLA nanospheres had comparatively steady properties and exerted obvious immune enhancement. Keywords: PHYP, optimal preparation condition, RSM, in vitro study

  18. Development and application of the Safe Performance Index as a risk-based methodology for identifying major hazard-related safety issues in underground coal mines

    Science.gov (United States)

    Kinilakodi, Harisha

    The underground coal mining industry has been under constant watch due to the high risk involved in its activities, and scrutiny increased because of the disasters that occurred in 2006-07. In the aftermath of the incidents, the U.S. Congress passed the Mine Improvement and New Emergency Response Act of 2006 (MINER Act), which strengthened the existing regulations and mandated new laws to address the various issues related to a safe working environment in the mines. Risk analysis in any form should be done on a regular basis to tackle the possibility of unwanted major hazard-related events such as explosions, outbursts, airbursts, inundations, spontaneous combustion, and roof fall instabilities. One of the responses by the Mine Safety and Health Administration (MSHA) in 2007 involved a new pattern of violations (POV) process to target mines with a poor safety performance, specifically to improve their safety. However, the 2010 disaster (worst in 40 years) gave an impression that the collective effort of the industry, federal/state agencies, and researchers to achieve the goal of zero fatalities and serious injuries has gone awry. The Safe Performance Index (SPI) methodology developed in this research is a straight-forward, effective, transparent, and reproducible approach that can help in identifying and addressing some of the existing issues while targeting (poor safety performance) mines which need help. It combines three injury and three citation measures that are scaled to have an equal mean (5.0) in a balanced way with proportionate weighting factors (0.05, 0.15, 0.30) and overall normalizing factor (15) into a mine safety performance evaluation tool. It can be used to assess the relative safety-related risk of mines, including by mine-size category. Using 2008 and 2009 data, comparisons were made of SPI-associated, normalized safety performance measures across mine-size categories, with emphasis on small-mine safety performance as compared to large- and

  19. Methodological Advances in Dea

    NARCIS (Netherlands)

    L. Cherchye (Laurens); G.T. Post (Thierry)

    2001-01-01

    textabstractWe survey the methodological advances in DEA over the last 25 years and discuss the necessary conditions for a sound empirical application. We hope this survey will contribute to the further dissemination of DEA, the knowledge of its relative strengths and weaknesses, and the tools

  20. NUSAM Methodology for Assessment.

    Energy Technology Data Exchange (ETDEWEB)

    Leach, Janice [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Snell, Mark K. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-07-01

    This document provides a methodology for the performance-based assessment of security systems designed for the protection of nuclear and radiological materials and the processes that produce and/or involve them. It is intended for use with both relatively simple installations and with highly regulated complex sites with demanding security requirements.

  1. Methodological Aspects of the IAEA State Level Concept and Acquisition Path Analysis: A State’s Nuclear Fuel Cycle, Related Capabilities, and the Quantification of Acquisition Paths

    International Nuclear Information System (INIS)

    Lance, K. Kim; Renda, Guido; Cojazzi, Giacomo G. M.

    2015-01-01

    Within its State Level Concept (SLC), the International Atomic Energy Agency (IAEA) envisions a State Level Approach (SLA) for safeguards implementation that considers, inter alia, a State’s nuclear and nuclear-related activities and capabilities as a whole when developing an annual implementation plan. Based on the assessed nuclear fuel cycle and related capabilities of a State, Acquisition Path Analysis (APA) identifies, characterizes, and prioritizes plausible routes for acquiring weapons-usable material to aid in safeguards implementation planning. A review of proposed APA methods and historical evidence indicates that assessments of pathway completion time can be fraught with uncertainty and subject to bias, potentially undermining safeguards effectiveness and efficiency. Based on considerations of theory and evidence, a number of methodological insights are identified to support consistent implementation and ongoing APA development. The use of algorithms to support APA and SLA processes in lieu of human judgement is a contentious issue requiring an evidence- based assessment and is also briefly discussed. This paper captures concepts derived primarily from open sources of information, including publications, presentations, and workshops on on-going APA development by the IAEA and various Member States Support Programs (MSSP) as well as relevant work found in the open literature. While implementation of the SLA has begun for a number of States, these SLAs are being updated and developed for other States. In light of these ongoing developments, the topics covered here should be considered a snapshot in time that does not reflect finished products and does not necessarily reflect official views.

  2. Researching experiences of cancer: the importance of methodology.

    Science.gov (United States)

    Entwistle, V; Tritter, J Q; Calnan, M

    2002-09-01

    This paper draws on contributions to and discussions at a recent MRC HSRC-sponsored workshop 'Researching users' experiences of health care: the case of cancer'. We focus on the methodological and ethical challenges that currently face researchers who use self-report methods to investigate experiences of cancer and cancer care. These challenges relate to: the theoretical and conceptual underpinnings of research; participation rates and participant profiles; data collection methods (the retrospective nature of accounts, description and measurement, and data collection as intervention); social desirability considerations; relationship considerations; the experiences of contributing to research; and the synthesis and presentation of findings. We suggest that methodological research to tackle these challenges should be integrated into substantive research projects to promote the development of a strong knowledge base about experiences of cancer and cancer care.

  3. A Nationwide View of Undergraduates' Interest in Earth-related Careers and Motivation to Tackle Environmental Challenges

    Science.gov (United States)

    Kastens, K. A.; Mara, V.; Turrin, M.

    2016-12-01

    The InTeGrate Attitudinal Instrument (IAI) is an on-line survey that probes students' interest in Earth-related careers, their concern about environmental issues, and their motivation to tackle grand challenges of environmental sustainability and resource limitations. The survey has been taken by several thousand students, at the beginning and end of more than a hundred different undergraduate courses throughout the United States. All courses include some Earth/environmental content, but not all in are geoscience departments. Although results vary somewhat between subpopulations, taken in the aggregate the data paint a nation-wide picture of the state of undergraduates' environmental interests and concerns. Regardless of intended career path, respondents place a high value on working for an organization that is committed to environmentally sustainable practices. Respondents consistently indicate that developments such as global climate change, loss of biodiversity, and water resource limitations are a problem; however, these same students are much less consistent when it comes to engaging in personal behaviors that would help mitigate environmental problems, such as washing clothes in cold water or using recyclable bags when shopping. When asked what factors or sources of information influence their decisions to engage in the specified environmentally sustainable behaviors, the factor most often cited, by a wide margin, is "desire to save money," followed by "concern about pollution." A final open-ended question asked students if they can envision using what they have learned in this course to help society overcome problems of environmental degradation, natural resources limitations, or other environmental issues; if yes, how, and if no, why not. Strong majorities said yes. Among the minority who said no, commonly cited reasons include lack of empowerment (I'm only one person, the problems are too big); course was too general and didn't address solutions; and

  4. A review of biodiversity-related issues and challenges in megadiverse Indonesia and other Southeast Asian countries

    Directory of Open Access Journals (Sweden)

    Kristina von Rintelen

    2017-09-01

    potential yet. A growing national interest in local biodiversity as a natural resource is a welcome development on one hand, but the risk of too many restrictions for, e.g., the science community (high level of bureaucracy at all project stages from planning phase, visa procedures, field work permits, scientific exchange and project managment issues, governmental budget cuts for basic research and restricted access to international literature for Indonesian researchers does significantly hamper the internationalization of biodiversity-related science. In the long run, Indonesia has to find a balance between protectionism and sensible access to its national biodiversity to tackle global challenges in biodiversity conservation, health issues, food security, and climate change.

  5. Testing methodologies

    Energy Technology Data Exchange (ETDEWEB)

    Bender, M.A.

    1990-01-01

    Several methodologies are available for screening human populations for exposure to ionizing radiation. Of these, aberration frequency determined in peripheral blood lymphocytes is the best developed. Individual exposures to large doses can easily be quantitated, and population exposures to occupational levels can be detected. However, determination of exposures to the very low doses anticipated from a low-level radioactive waste disposal site is more problematical. Aberrations occur spontaneously, without known cause. Exposure to radiation induces no new or novel types, but only increases their frequency. The limitations of chromosomal aberration dosimetry for detecting low level radiation exposures lie mainly in the statistical signal to noise'' problem, the distribution of aberrations among cells and among individuals, and the possible induction of aberrations by other environmental occupational or medical exposures. However, certain features of the human peripheral lymphocyte-chromosomal aberration system make it useful in screening for certain types of exposures. Future technical developments may make chromosomal aberration dosimetry more useful for low-level radiation exposures. Other methods, measuring gene mutations or even minute changes on the DNA level, while presently less will developed techniques, may eventually become even more practical and sensitive assays for human radiation exposure. 15 refs.

  6. Testing methodologies

    International Nuclear Information System (INIS)

    Bender, M.A.

    1990-01-01

    Several methodologies are available for screening human populations for exposure to ionizing radiation. Of these, aberration frequency determined in peripheral blood lymphocytes is the best developed. Individual exposures to large doses can easily be quantitated, and population exposures to occupational levels can be detected. However, determination of exposures to the very low doses anticipated from a low-level radioactive waste disposal site is more problematical. Aberrations occur spontaneously, without known cause. Exposure to radiation induces no new or novel types, but only increases their frequency. The limitations of chromosomal aberration dosimetry for detecting low level radiation exposures lie mainly in the statistical ''signal to noise'' problem, the distribution of aberrations among cells and among individuals, and the possible induction of aberrations by other environmental occupational or medical exposures. However, certain features of the human peripheral lymphocyte-chromosomal aberration system make it useful in screening for certain types of exposures. Future technical developments may make chromosomal aberration dosimetry more useful for low-level radiation exposures. Other methods, measuring gene mutations or even minute changes on the DNA level, while presently less will developed techniques, may eventually become even more practical and sensitive assays for human radiation exposure. 15 refs

  7. International conference on fast reactors and related fuel cycles (FR09): Challenges and opportunities. CN-176 presentations

    International Nuclear Information System (INIS)

    2009-01-01

    and development, as well as in design, has not been reported in a coordinated manner, which has made planning and implementation of expensive research and technology development programmes rather difficult. There is a perceived need for an appropriate forum to achieve the twin objectives of exchanging experience and innovative ideas among experts, and of sharing knowledge and mentoring, whereby experienced scientists and technologists, as well as fast reactor programme managers, would share their perspectives with the future generation of young scientists and technologists, helping them to choose research problems of eminence and pursue their careers to meet the challenges of the development of fast reactors with recycle. After almost 20 years, this is also the appropriate time, as fast reactor programmes are currently on an accelerated growth path in many countries of the world. It is in light of this that the IAEA convened on 7-11 December 2009 in Kyoto, Japan, the International Conference on 'Fast Reactors and Related Fuel Cycles - Challenges and Opportunities (FR09)', hosted by the Japan Atomic Energy Agency. This conference aimed at promoting the exchange of information on national and multinational programmes and new developments and experience, with the goal of identifying and critically reviewing problems of importance, and stimulating and facilitating cooperation, development and successful deployment of fast reactors in an expeditious manner

  8. No difference in health-related quality of life, after a food challenge with cashew nut in children participating in a clinical trial

    NARCIS (Netherlands)

    van der Valk, J. P. M.; van Wijk, R. Gerth; Flokstra-de Blok, B. M. J.; van der Velde, J. L.; de Groot, H.; Wichers, H. J.; Dubois, A. E. J.; de Jong, N. W.

    2016-01-01

    Background: Previous studies showed that health-related quality of life (HRQL) significantly improved after the food challenge, with greater improvements in HRQL after a negative outcome than after a positive outcome. It is currently unknown whether this also occurs in patients undergoing DBPCFCs

  9. Ethnographic Methodology

    DEFF Research Database (Denmark)

    Svensson, Christian Franklin

    is reinvested in the enterprise for these purposes. The research has provided a framework for understanding how vulnerable employees reflect and navigate their day-to-day experiences, specifically in relation to the local municipality. The case discusses themes of how fieldwork requires being able to improvise...

  10. Cognitive and Motivational Challenges in Writing: Studying the Relation with Writing Performance across Students' Gender and Achievement Level

    Science.gov (United States)

    De Smedt, Fien; Merchie, Emmelien; Barendse, Mariska; Rosseel, Yves; De Naeghel, Jessie; Van Keer, Hilde

    2018-01-01

    In the past, several assessment reports on writing repeatedly showed that elementary school students do not develop the essential writing skills to be successful in school. In this respect, prior research has pointed to the fact that cognitive and motivational challenges are at the root of the rather basic level of elementary students' writing…

  11. Training Emotional Intelligence Related to Treatment Skills of Staff Working with Clients with Intellectual Disabilities and Challenging Behaviour

    Science.gov (United States)

    Zijlmans, L. J. M.; Embregts, P. J. C. M.; Gerits, L.; Bosman, A. M. T.; Derksen, J. J. L.

    2011-01-01

    Background: Staff working with clients with intellectual disabilities (ID) who display challenging behaviour may contribute to the continuation of this behaviour, because it causes emotional reactions such as anxiety, anger and annoyance, which may prohibit adequate response behaviour. To enhance staff behaviour and treatment skills a training…

  12. The challenge for genetic epidemiologists: how to analyze large numbers of SNPs in relation to complex diseases

    NARCIS (Netherlands)

    Heidema, A.G.; Boer, J.M.A.; Nagelkerke, N.; Mariman, E.C.M.; A, van der D.L.; Feskens, E.J.M.

    2006-01-01

    Genetic epidemiologists have taken the challenge to identify genetic polymorphisms involved in the development of diseases. Many have collected data on large numbers of genetic markers but are not familiar with available methods to assess their association with complex diseases. Statistical methods

  13. Hip/femur fractures associated with the use of benzodiazepines (anxiolytics, hypnotics and related drugs) : A methodological approach to assess consistencies across databases from the PROTECT-EU project

    NARCIS (Netherlands)

    Requena, Gema; Huerta, Consuelo; Gardarsdottir, Helga; Logie, John; González-González, Rocío; Abbing-Karahagopian, Victoria; Miret, Montserrat; Schneider, Cornelia; Souverein, Patrick C.; Webb, Dave; Afonso, Ana; Boudiaf, Nada; Martin, Elisa; Oliva, Belén; Alvarez, Arturo; de Groot, Mark C H; Bate, Andrew; Johansson, Saga; Schlienger, Raymond; Reynolds, Robert; Klungel, Olaf H.; de Abajo, Francisco J.

    2016-01-01

    Background: Results from observational studies may be inconsistent because of variations in methodological and clinical factors that may be intrinsically related to the database (DB) where the study is performed. Objectives: The objectives of this paper were to evaluate the impact of applying a

  14. Hip/femur fractures associated with the use of benzodiazepines (anxiolytics, hypnotics and related drugs) : a methodological approach to assess consistencies across databases from the PROTECT-EU project

    NARCIS (Netherlands)

    Requena, Gema; Huerta, Consuelo; Gardarsdottir, Helga; Logie, John; González-González, Rocío; Abbing-Karahagopian, Victoria; Miret, Montserrat; Schneider, Cornelia; Souverein, Patrick C; Webb, Dave; Afonso, Ana; Boudiaf, Nada; Martin, Elisa; Oliva, Belén; Alvarez, Arturo; De Groot, Mark C H; Bate, Andrew; Johansson, Saga; Schlienger, Raymond; Reynolds, Robert; Klungel, Olaf H; de Abajo, Francisco J

    2016-01-01

    BACKGROUND: Results from observational studies may be inconsistent because of variations in methodological and clinical factors that may be intrinsically related to the database (DB) where the study is performed. OBJECTIVES: The objectives of this paper were to evaluate the impact of applying a

  15. Exploring the Philosophical Underpinnings of Research: Relating Ontology and Epistemology to the Methodology and Methods of the Scientific, Interpretive, and Critical Research Paradigms

    Science.gov (United States)

    Scotland, James

    2012-01-01

    This paper explores the philosophical underpinnings of three major educational research paradigms: scientific, interpretive, and critical. The aim was to outline and explore the interrelationships between each paradigm's ontology, epistemology, methodology and methods. This paper reveals and then discusses some of the underlying assumptions of…

  16. A multi-methodological approach to study the temporal and spatial distribution of air quality related to road transport emissions in Madrid, Spain

    Science.gov (United States)

    Perez, Pedro; Miranda, Regina

    2013-04-01

    The traffic-related atmospheric emissions, composition and transport of greenhouse gases (GHGs) and air toxic pollutants (ATPs), are an important environmental problem that affect climate change and air pollution in Madrid, Spain. Carbon dioxide (CO2) affects the regional weather and particularly fine particle matter (PM) translocate to the people resulting in local health problems. As the main source of emissions comes from road transport, and subsequent combustion of fossil fuels, air quality deterioration may be elevated during weekdays and peak hours. We postulate that traffic-related air quality (CO2, methane CH4, PM, volatile organic compounds VOCs, nitrogen oxides NOx and carbon monoxide CO contents) impairs epidemiology in part via effects on health and disease development, likely increasing the external costs of transport in terms of climate change and air pollution. First, the paper intends to estimate the local air quality related to the road transport emissions of weeks over a domain covering Madrid (used as a case study). The local air quality model (LAQM) is based on gridded and shaped emission fields. The European Environmental Agency (EEA) COPERT modeling system will provide GHGs and ATPs gridded and shaped emission data and mobile source parameters, available for Madrid from preliminary emission inventory records of the Municipality of Madrid and from disaggregated traffic counts of the Traffic Engineering Company and the Metropolitan Company of Metro (METRO-Madrid). The paper intends to obtain estimates of GHGs and ATPs concentrations commensurate with available ground measurements, 24-hour average values, from the Municipality of Madrid. The comparison between estimated concentrations and measurements must show small errors (e.g. fractional error, fractional bias and coefficient of determination). The paper's expected results must determine spatial and temporal patterns in Madrid. The estimates will be used to cross check the primary local

  17. Challenges related to methanization - Bibliographical synthesis by France Nature Environnement. Opinion of FNE on methanization: Which challenges and which desirable development? Methascope: assessment support tool for a methanization project

    International Nuclear Information System (INIS)

    Desaunay, Thomas; Mathien, Adeline; Dorioz, Camille; Saint-Aubin, Thibaud; Banaszuk, Agnes; Badereau, Benedicte de; Capiez, Nathalie; Zoffoli, Maxime

    2014-12-01

    A first document proposes a bibliographical synthesis on the various challenges related to methanization. It addresses the following issues: biogas and public policies, methanization as a natural process of transformation of organic matter, different installations for different territories, matters which can be used in methanization, biogas as a renewable and local energy which can be transformed according to needs, properties and uses of digestate, choice between composting and methanization, energetic crops, methanization and nitrates, regulation, potential risks and pollutions, economic profitability of projects. The second document states the FNE's opinion on methanization, its challenges and the associated desirable development. The third document is a guide which aims at providing knowledge on methanization, at easing dialogue between actors of a territory, and at elaborating a position and an opinion with respect to a specific methanization project on a territory

  18. Statement to International Conference on Fast Reactors and Related Fuel Cycles: Challenges and Opportunities, 7 December 2009, Kyoto, Japan

    International Nuclear Information System (INIS)

    Amano, Yukiya

    2009-01-01

    Full text: Distinguished Guests, Ladies and Gentlemen, It is my honour to address participants at this opening session of the International Conference on Fast Reactors and Related Fuel Cycles: Challenges and Opportunities, organized by the IAEA and hosted by the Japan Atomic Energy Agency. Fast reactor technology has the potential to ensure that energy resources which would last hundreds of years with the technology we are using today will actually last several thousand years. In other words it can withstand enormous increases in demand. This innovative technology also reduces the risk to the environment and helps to limit the burden that will be placed on future generations in the form of waste products. The coming year will be an exciting one for the development of fast-spectrum nuclear reactors. We expect to reach many important milestones: - the first criticality of the China Experimental Fast Reactor; - the restart of the Monju prototype fast reactor in Japan; and - the new insights we will gain through the end-of-life studies at the Phenix reactor in France. In the near future, new fast reactors will be commissioned: the 500MW(e) Prototype Fast Breeder Reactor in India, the first in a series of five of the same type, and the BN-800 reactor in the Russian Federation. Moreover, France, Japan, India, China and the Republic of Korea are preparing advanced prototypes, demonstration or commercial reactors for the 2020-2030 period. Nuclear power is set to be an increasingly important part of the global energy mix in the coming decades as demand for energy grows. Scores of countries in both the developed and developing world have told the IAEA that they are interested in introducing nuclear power. The 30 countries which already have nuclear power reactors are set to build more. This trend is likely to be accompanied by accelerated deployment of fast reactors. Continued advances in research and technology development are necessary to ensure improved economics and

  19. Smart Industry Research in the Field of HRM : Resetting Job Design as an Example of Upcoming Challenges

    NARCIS (Netherlands)

    Habraken, Milou Maria Petronella; Bondarouk, Tatiana; Bondarouk, Tanya; Ruel, Huub; Parry, Emma

    2017-01-01

    Purpose – This chapter aims to encourage and guide Smart Industry HRM-related research by addressing upcoming challenges developed using a Job Design lens. Methodology/approach – The challenges are constructed based on a developed overview of the existing body of work related to Job Design and a

  20. Inverted U-Shaped Curvilinear Relationship between Challenge and One's Intrinsic Motivation: Evidence from Event-Related Potentials.

    Science.gov (United States)

    Ma, Qingguo; Pei, Guanxiong; Meng, Liang

    2017-01-01

    The balance between task demand and one's competence is critical for the maintenance of intrinsic motivation. According to Flow theory and Self-determination theory, optimal challenge gives rise to the maximum intrinsic motivation, and an inverted U-shaped curvilinear relationship between perceived challenge and one's intrinsic motivation is suggested. In order to provide direct experimental evidences for predictions of these theories, in this study, we employed the two-player StopWatch game that we previously designed, which made references to the game format of a badminton tournament. According to our manipulation, a male participant was defeated by the same-sex player paired with him (played by a well-trained confederate of the experimenter) in two matches, one with a wide margin (the complete defeat condition) and another with a narrow one (the near miss condition). Participants performed better and reported to enjoy the near miss match to a greater extent. Besides, an enlarged Stimulus-preceding negativity was elicited when participants were actively anticipating outcomes in the near miss condition, suggesting greater anticipatory attention toward the outcome and an enhanced intrinsic motivation to win. Thus, converging electrophysiological evidences from this study and our former study confirmed the inverted U-shaped curvilinear relationship between perceived challenge and one's intrinsic motivation.

  1. Examining Challenges Related to the Production of Actionable Climate Knowledge for Adaptation Decision-Making: A Focus on Climate Knowledge System Producers

    Science.gov (United States)

    Ernst, K.; Preston, B. L.; Tenggren, S.; Klein, R.; Gerger-Swartling, Å.

    2017-12-01

    Many challenges to adaptation decision-making and action have been identified across peer-reviewed and gray literature. These challenges have primarily focused on the use of climate knowledge for adaptation decision-making, the process of adaptation decision-making, and the needs of the decision-maker. Studies on climate change knowledge systems often discuss the imperative role of climate knowledge producers in adaptation decision-making processes and stress the need for producers to engage in knowledge co-production activities and to more effectively meet decision-maker needs. While the influence of climate knowledge producers on the co-production of science for adaptation decision-making is well-recognized, hardly any research has taken a direct approach to analyzing the challenges that climate knowledge producers face when undertaking science co-production. Those challenges can influence the process of knowledge production and may hinder the creation, utilization, and dissemination of actionable knowledge for adaptation decision-making. This study involves semi-structured interviews, focus groups, and participant observations to analyze, identify, and contextualize the challenges that climate knowledge producers in Sweden face as they endeavor to create effective climate knowledge systems for multiple contexts, scales, and levels across the European Union. Preliminary findings identify complex challenges related to education, training, and support; motivation, willingness, and culture; varying levels of prioritization; professional roles and responsibilities; the type and amount of resources available; and professional incentive structures. These challenges exist at varying scales and levels across individuals, organizations, networks, institutions, and disciplines. This study suggests that the creation of actionable knowledge for adaptation decision-making is not supported across scales and levels in the climate knowledge production landscape. Additionally

  2. The role of herbaceous crops in soil carbon and nitrogen cycles in relation to soil management . methodological approaches and innovative technologies

    International Nuclear Information System (INIS)

    Mohamed, M.A.A.

    2010-01-01

    Soil organic matter is an important pool within the total organic carbon of the planet,being equal to twice that if the atmosphere and three times the biotic one.Organic carbon sequestration in agricultural soils is therefore considered one of the most effective tools to counterbalance the emission of CO 2 from fossil fuels combustion. The role of below ground plant parts in carbon sequestration is much more difficult that of above.ground parts because of the open issues about the determination of root biometrics and root exhudates. Recent literature indicates that root biomass is probably much larger than classically believed and that root surface where exhudation occurs is also underestimated, and so is its role in the rhizosphere.The general objective of this thesis is the evaluation of carbon sequestration in sorghum as a function of soil management. A specific objective is to approach methodological problems relevant to the accurate quantification of the contribution of below ground plant structures to athmosferic carbon sequestration. This objective will be approached through a thorough review of the literature and an experimental setup with different soil management systems in relation to organic matter. In the review special attention is given to the applied tracer methods. The contribution of plant derived organic substances to the SOM turnover obtained with 13 C natural abundance is also reviewed. A related objective is the monitoring of nitrogen dynamics discriminating the contribution of organic matter applied to the soil. In addition to organic C, soil may also contain inorganic C in the form of carbonates. This is of particular relevance to dry lands because calcification and formation of secondary carbonate is an important process in arid and semi-arid regions. Consequently the largest accumulations of carbonate occur in the soils of arid and semi-arid areas. Dynamics of the inorganic carbon pool are poorly understood although it is normally quite

  3. A Methodology for Validating Safety Heuristics Using Clinical Simulations: Identifying and Preventing Possible Technology-Induced Errors Related to Using Health Information Systems

    Science.gov (United States)

    Borycki, Elizabeth; Kushniruk, Andre; Carvalho, Christopher

    2013-01-01

    Internationally, health information systems (HIS) safety has emerged as a significant concern for governments. Recently, research has emerged that has documented the ability of HIS to be implicated in the harm and death of patients. Researchers have attempted to develop methods that can be used to prevent or reduce technology-induced errors. Some researchers are developing methods that can be employed prior to systems release. These methods include the development of safety heuristics and clinical simulations. In this paper, we outline our methodology for developing safety heuristics specific to identifying the features or functions of a HIS user interface design that may lead to technology-induced errors. We follow this with a description of a methodological approach to validate these heuristics using clinical simulations. PMID:23606902

  4. "I don't like talking about it because that's not who I am": Challenges children face during epilepsy-related family communication.

    Science.gov (United States)

    O'Toole, S; Lambert, V; Gallagher, P; Shahwan, A; Austin, J K

    2016-09-01

    Childhood epilepsy not only significantly impacts a child's social relationships and psychosocial wellbeing, but it can also cause disruptions in family relations. Children living with epilepsy often rely on parental figures for guidance in relation to their condition. A paucity of research has examined the challenges for children when communicating about epilepsy with parental figures. This qualitative study explored the challenges faced by children when talking about epilepsy with their parent(s). Semi-structured interviews were conducted with 29 children (aged 6-16 years) living with epilepsy. Participants were recruited from a neurology department of a major pediatric hospital and from a national epilepsy association. Interviews were transcribed verbatim and thematically analyzed. Findings revealed four themes: communication impeding normalcy, parental overprotection, parental reactions to epilepsy-related communication, and restriction of activities as a consequence of epilepsy-related communication. The study highlights the need for a greater understanding of parent-child dialogue surrounding epilepsy and where challenges lie for children in conversing about their condition. Parents and health care professionals play a pivotal role in facilitating an environment where children feel comfortable talking about epilepsy. This information will be instrumental in the development of a communication-based intervention for families living with epilepsy. © The Author(s) 2016.

  5. The Micronesia Challenge: Assessing the Relative Contribution of Stressors on Coral Reefs to Facilitate Science-to-Management Feedback.

    Science.gov (United States)

    Houk, Peter; Camacho, Rodney; Johnson, Steven; McLean, Matthew; Maxin, Selino; Anson, Jorg; Joseph, Eugene; Nedlic, Osamu; Luckymis, Marston; Adams, Katrina; Hess, Don; Kabua, Emma; Yalon, Anthony; Buthung, Eva; Graham, Curtis; Leberer, Trina; Taylor, Brett; van Woesik, Robert

    2015-01-01

    Fishing and pollution are chronic stressors that can prolong recovery of coral reefs and contribute to ecosystem decline. While this premise is generally accepted, management interventions are complicated because the contributions from individual stressors are difficult to distinguish. The present study examined the extent to which fishing pressure and pollution predicted progress towards the Micronesia Challenge, an international conservation strategy initiated by the political leaders of 6 nations to conserve at least 30% of marine resources by 2020. The analyses were rooted in a defined measure of coral-reef-ecosystem condition, comprised of biological metrics that described functional processes on coral reefs. We report that only 42% of the major reef habitats exceeded the ecosystem-condition threshold established by the Micronesia Challenge. Fishing pressure acting alone on outer reefs, or in combination with pollution in some lagoons, best predicted both the decline and variance in ecosystem condition. High variances among ecosystem-condition scores reflected the large gaps between the best and worst reefs, and suggested that the current scores were unlikely to remain stable through time because of low redundancy. Accounting for the presence of marine protected area (MPA) networks in statistical models did little to improve the models' predictive capabilities, suggesting limited efficacy of MPAs when grouped together across the region. Yet, localized benefits of MPAs existed and are expected to increase over time. Sensitivity analyses suggested that (i) grazing by large herbivores, (ii) high functional diversity of herbivores, and (iii) high predator biomass were most sensitive to fishing pressure, and were required for high ecosystem-condition scores. Linking comprehensive fisheries management policies with these sensitive metrics, and targeting the management of pollution, will strengthen the Micronesia Challenge and preserve ecosystem services that coral

  6. The Micronesia Challenge: Assessing the Relative Contribution of Stressors on Coral Reefs to Facilitate Science-to-Management Feedback.

    Directory of Open Access Journals (Sweden)

    Peter Houk

    Full Text Available Fishing and pollution are chronic stressors that can prolong recovery of coral reefs and contribute to ecosystem decline. While this premise is generally accepted, management interventions are complicated because the contributions from individual stressors are difficult to distinguish. The present study examined the extent to which fishing pressure and pollution predicted progress towards the Micronesia Challenge, an international conservation strategy initiated by the political leaders of 6 nations to conserve at least 30% of marine resources by 2020. The analyses were rooted in a defined measure of coral-reef-ecosystem condition, comprised of biological metrics that described functional processes on coral reefs. We report that only 42% of the major reef habitats exceeded the ecosystem-condition threshold established by the Micronesia Challenge. Fishing pressure acting alone on outer reefs, or in combination with pollution in some lagoons, best predicted both the decline and variance in ecosystem condition. High variances among ecosystem-condition scores reflected the large gaps between the best and worst reefs, and suggested that the current scores were unlikely to remain stable through time because of low redundancy. Accounting for the presence of marine protected area (MPA networks in statistical models did little to improve the models' predictive capabilities, suggesting limited efficacy of MPAs when grouped together across the region. Yet, localized benefits of MPAs existed and are expected to increase over time. Sensitivity analyses suggested that (i grazing by large herbivores, (ii high functional diversity of herbivores, and (iii high predator biomass were most sensitive to fishing pressure, and were required for high ecosystem-condition scores. Linking comprehensive fisheries management policies with these sensitive metrics, and targeting the management of pollution, will strengthen the Micronesia Challenge and preserve ecosystem

  7. Leader-member exchange and work-family interactions: the mediating role of self-reported challenge- and hindrance-related stress.

    Science.gov (United States)

    Culbertson, Satoris S; Huffman, Ann H; Alden-Anderson, Rachel

    2010-01-01

    The authors examined the relations among 4 components of the leader-member exchange (LMX) relationship (i.e., contribution, affect, loyalty, and professional respect) and the level of work-family conflict and work-family facilitation that an employee experiences. Further, the authors examined the mediating role of challenge- and hindrance-related self-reported stress on relations. In doing this, the authors linked positive and negative aspects of LMX, stressors, work-family conflict, and work-family facilitation. Data from a sample of full-time employed individuals support some hypothesized relations between components of LMX and work-family interactions. Also, results support the mediating role of hindrance-related stress in the relation between (a) the affect and loyalty components of LMX and (b) work-family conflict. The authors discuss the implications and limitations of their findings.

  8. A Methodological Approach to Assess the Impact of Smarting Action on Electricity Transmission and Distribution Networks Related to Europe 2020 Targets

    Directory of Open Access Journals (Sweden)

    Andrea Bonfiglio

    2017-01-01

    Full Text Available The achievement of the so-called 2020 targets requested by the European Union (EU has determined a significant growth of proposals of solutions and of technical projects aiming at reducing the CO2 emissions and increasing the energy efficiency, as well as the penetration of Renewable Energy Sources (RES in the electric network. As many of them ask for funding from the EU itself, there is the necessity to define a methodology to rank them and decide which projects should be sponsored to obtain the maximum effect on the EU 2020 targets. The present paper aims at (i defining a set of Key Performance Indicators (KPIs to compare different proposals, (ii proposing an analytical methodology to evaluate the defined KPIs and (iii evaluating the maximum impact that the considered action is capable of producing. The proposed methodology is applied to a set of possible interventions performed on a benchmark transmission network test case, in order to show that the defined indicators can be either calculated or measured and that they are useful to rank different “smarting actions”.

  9. Challenges related to the management of energy and transportation infrastructures within the context of future eco cities

    Energy Technology Data Exchange (ETDEWEB)

    Schmitt, Laurent; Culver, Keith; Gaudin, Etienne; Sun, David

    2010-09-15

    The 100 years from 1950 to 2050 will be remembered for the greatest social, cultural, economic and environmental transformation in history - the urbanization of humanity. With half of us now occupying urban space, the future of the human species is tied to the city - Anna Tibaijuka, Under-Secretary-General of the United Nations and Executive Director UN-HABITAT, in remarks at the third session of the World Urban Forum in Vancouver, Canada, in 2006. The urbanization of humanity is both a fact and a challenge. 3.5 billion people live in cities now, and 6 billion people will live in cities by 2050.

  10. Relating follicly-challenged compact stars to bald black holes: A link between two no-hair properties

    Science.gov (United States)

    Yagi, Kent; Yunes, Nicolás

    2015-05-01

    Compact stars satisfy certain no-hair relations through which their multipole moments are given by their mass, spin and quadrupole moment. These relations are approximately independent of their equation of state, relating pressure to density. Such relations are similar to the black hole no-hair theorems, but these possess event horizons inside which information that led to their formation can hide. Compact stars do not possess horizons, so whether their no-hair relations are related to the black hole ones is unclear. We investigate how the two relations are related by studying relations among multipole moments for compact stars with anisotropic pressure as a toy model, which allows such stars to be more compact than those with isotropic pressure. We here show numerically that the compact star no-hair relations approach the black hole ones as the compactness approaches that of a black hole. We also prove analytically that the current dipole moment exactly reaches the black hole limit quadratically in compactness as strongly anisotropic stars approach the black hole limit. We moreover show that compact stars become progressively oblate in this limit, even if prolate at low compactness due to strong anisotropies.

  11. Intelligent systems engineering methodology

    Science.gov (United States)

    Fouse, Scott

    1990-01-01

    An added challenge for the designers of large scale systems such as Space Station Freedom is the appropriate incorporation of intelligent system technology (artificial intelligence, expert systems, knowledge-based systems, etc.) into their requirements and design. This presentation will describe a view of systems engineering which successfully addresses several aspects of this complex problem: design of large scale systems, design with requirements that are so complex they only completely unfold during the development of a baseline system and even then continue to evolve throughout the system's life cycle, design that involves the incorporation of new technologies, and design and development that takes place with many players in a distributed manner yet can be easily integrated to meet a single view of the requirements. The first generation of this methodology was developed and evolved jointly by ISX and the Lockheed Aeronautical Systems Company over the past five years on the Defense Advanced Research Projects Agency/Air Force Pilot's Associate Program, one of the largest, most complex, and most successful intelligent systems constructed to date. As the methodology has evolved it has also been applied successfully to a number of other projects. Some of the lessons learned from this experience may be applicable to Freedom.

  12. Contextual factors, methodological principles and teacher cognition

    Directory of Open Access Journals (Sweden)

    Rupert Walsh

    2014-01-01

    Full Text Available Teachers in various contexts worldwide are sometimes unfairly criticized for not putting teaching methods developed for the well-resourced classrooms of Western countries into practice. Factors such as the teachers’ “misconceptualizations” of “imported” methods, including Communicative Language Teaching (CLT, are often blamed, though the challenges imposed by “contextual demands,” such as large class sizes, are sometimes recognised. Meanwhile, there is sometimes an assumption that in the West there is a happy congruence between policy supportive of CLT or Task-Based Language Teaching, teacher education and supervision, and curriculum design with teachers’ cognitions and their practices. Our case study of three EFL teachers at a UK adult education college is motivated by a wish to question this assumption. Findings from observational and interview data suggest the practices of two teachers were largely consistent with their methodological principles, relating to stronger and weaker forms of CLT respectively, as well as to more general educational principles, such as a concern for learners; the supportive environment seemed to help. The third teacher appeared to put “difficult” contextual factors, for example, tests, ahead of methodological principles without, however, obviously benefiting. Implications highlight the important role of teacher cognition research in challenging cultural assumptions.

  13. Challenged assumptions and invisible effects

    DEFF Research Database (Denmark)

    Wimmelmann, Camilla Lawaetz; Vitus, Kathrine; Jervelund, Signe Smith

    2017-01-01

    for the implementation—different from the assumed conditions—not only challenge the implementation of the intervention but also potentially produce unanticipated yet valuable effects. Research implications – Newly arrived immigrants represent a hugely diverse and heterogeneous group of people with differing values......Purpose – The objective of this study was to examine any unanticipated effects of an educational intervention among newly arrived adult immigrants attending a language school in Denmark. Methodology – A qualitative case study was conducted including interviews with nine informants, observations....... In particular, the assumed (power) relations inherent in immigrant-oriented educational health interventions, in which immigrants are in a novice position, are challenged, as the immigrants are experienced adults (and parents) in regard to healthcare. The paper proposes that such unexpected conditions...

  14. Key Methodological Aspects of Translators' Training in Ukraine and in the USA

    Science.gov (United States)

    Skyba, Kateryna

    2015-01-01

    The diversity of international relations in the globalized world has influenced the role of a translator that is becoming more and more important. Translators' training institutions today are to work out and to implement the best teaching methodology taking into consideration the new challenges of modern multinational and multicultural society.…

  15. Evaluating electronic performance support systems: A methodology focused on future use-in-practice

    NARCIS (Netherlands)

    Collis, Betty; Verwijs, C.A.

    1995-01-01

    Electronic performance support systems, as an emerging type of software environment, present many new challenges in relation to effective evaluation. In this paper, a global approach to a 'usage-orientated' evaluation methodology for software product is presented, followed by a specific example of

  16. Institutional review board challenges related to community-based participatory research on human exposure to environmental toxins: A case study

    Directory of Open Access Journals (Sweden)

    Rudel Ruthann A

    2010-07-01

    Full Text Available Abstract Background We report on the challenges of obtaining Institutional Review Board (IRB coverage for a community-based participatory research (CBPR environmental justice project, which involved reporting biomonitoring and household exposure results to participants, and included lay participation in research. Methods We draw on our experiences guiding a multi-partner CBPR project through university and state Institutional Review Board reviews, and other CBPR colleagues' written accounts and conference presentations and discussions. We also interviewed academics involved in CBPR to learn of their challenges with Institutional Review Boards. Results We found that Institutional Review Boards are generally unfamiliar with CBPR, reluctant to oversee community partners, and resistant to ongoing researcher-participant interaction. Institutional Review Boards sometimes unintentionally violate the very principles of beneficence and justice which they are supposed to uphold. For example, some Institutional Review Boards refuse to allow report-back of individual data to participants, which contradicts the CBPR principles that guide a growing number of projects. This causes significant delays and may divert research and dissemination efforts. Our extensive education of our university Institutional Review Board convinced them to provide human subjects protection coverage for two community-based organizations in our partnership. Conclusions IRBs and funders should develop clear, routine review guidelines that respect the unique qualities of CBPR, while researchers and community partners can educate IRB staff and board members about the objectives, ethical frameworks, and research methods of CBPR. These strategies can better protect research participants from the harm of unnecessary delays and exclusion from the research process, while facilitating the ethical communication of study results to participants and communities.

  17. Challenges in war-related thoracic injury faced by French military surgeons in Afghanistan (2009-2013).

    Science.gov (United States)

    de Lesquen, Henri; Beranger, Fabien; Berbis, Julie; Boddaert, Guillaume; Poichotte, Antoine; Pons, Francois; Avaro, Jean-Philippe

    2016-09-01

    This study reports the challenges faced by French military surgeons in the management of thoracic injury during the latest Afghanistan war. From January 2009 to April 2013, all of the civilian, French and Coalition casualties admitted to French NATO Combat Support Hospital situated on Kabul were prospectively recorded in the French Military Health Service Registry (OPEX(®)). Only penetrating and blunt thoracic trauma patients were retrospectively included. Eighty-nine casualties were included who were mainly civilian (61%) and men (94%) with a mean age of 27.9 years old. Surgeons dealt with polytraumas (78%), severe injuries (mean Injury Severity Score=39.2) and penetrating wounds (96%) due to explosion in 37%, gunshot in 53% and stabbing in 9%. Most of casualties were first observed or drained (n=56). In this non-operative group more than 40% of casualties needed further actions. In the operative group, Damage Control Thoracotomy (n=22) was performed to stop ongoing bleeding and air leakage and Emergency Department Thoracotomy (n=11) for agonal patient. Casualties suffered from hemothorax (60%), pneumothorax (39%), diaphragmatic (37%), lung (35%), heart or great vessels (20%) injuries. The main actions were diaphragmatic sutures (n=25), lung resections (wedge n=6, lobectomy n=4) and haemostasis (intercostal artery ligation n=3, heart injury repairs n=5, great vessels injury repairs n=5). Overall mortality was 11%. The rate of subsequent surgery was 34%. The analysis of the OPEX(®) registry reflects the thoracic surgical challenges of general (visceral) surgeons serving in combat environment during the latest Afghanistan War. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Clinical trial methodology

    National Research Council Canada - National Science Library

    Peace, Karl E; Chen, Ding-Geng

    2011-01-01

    ... in the pharmaceutical industry, Clinical trial methodology emphasizes the importance of statistical thinking in clinical research and presents the methodology as a key component of clinical research...

  19. A Dialogue with Social Media Experts: Measurement and Challenges of Social Media Use in Chinese Public Relations Practice

    OpenAIRE

    Yi Luo; Hua Jiang

    2012-01-01

    With the advent and increasing popularity of new communication technologies, social media tools have been widely used in corporate organization-public communication. The extant literature on social media use in public relations practice has largely centered on the ways social media tools have transformed the practice of public relations in the United States. Limited studies have examined the role of social media in China. The present study represents one of the first to investigate the measur...

  20. Imaginative methodologies in the social sciences

    DEFF Research Database (Denmark)

    Imaginative Methodologies develops, expands and challenges conventional social scientific methodology and language by way of literary, poetic and other alternative sources of inspiration. Sociologists, social workers, anthropologists, criminologists and psychologists all try to rethink, provoke...... and reignite social scientific methodology. Imaginative Methodologies challenges the mainstream social science methodological orthodoxy closely guarding the boundaries between the social sciences and the arts and humanities, pointing out that authors and artists are often engaged in projects parallel to those...... of the social sciences and vice versa, and that artistic and cultural productions today do not constitute a specialist field, but are integral to our social reality. The book will be of interest to scholars and students in the social sciences and across the arts and humanities working with questions...