WorldWideScience

Sample records for method offers possibilities

  1. Simposium 19: Teaching Offers Many Possibilities

    Directory of Open Access Journals (Sweden)

    Denise Vaz Macedo

    2014-08-01

    Full Text Available K-Education(PortugueseChair: V. TrindadeBayardo Torres; Clovis Wannmacher; Denise Macedo  Teaching Offers Many Possibilities Denise Vaz Macedo Biochemistry Department, Biology Institute, Unicamp, Campinas, Brazil.   In the last years my research lines are maintained exclusively through my biochemistry teaching activities at graduation and specialization course (360h. The teaching methodology used was developed over these 20 years into the classroom research. It is based on five practical activities carried out at the initial moment by the students themselves, who monitor the effects of different physical activity situations through the measurement of some plasma metabolites on point of care devices. After instructions the students perform the exercises collects and tabulate the data generated and document all the doubts arising. The educational goal right now is to show that the theory related to muscle contraction, the ATP-producing metabolic pathways is linked to their profession. At adequate moments each group presents to the whole class the practical activity carried out, the data and the doubts produced. After a fully discussion the students are able to relate the data to the studied theory. Also the initial doubts are clarified. A questionnaire applied before and after the discipline indicates the learning effectiveness of this method. Some other results: the students who have demonstrated special interest in the classroom normally join into de lab. Simultaneously they are also prepared for the teaching activity. The demand of specialization course is greater than the supply. The financial resources generated are expressive and administered by the University Foundation. They are fully applied to purchase permanent and consumption materials and for the payment of eventual scholarships for lab researchers. The publication in indexed journals has been constant and regular, and the obtained experimental results always return to the

  2. Plant nominal power uprating offers attractive possibilities

    International Nuclear Information System (INIS)

    Bruyere, Michel

    2004-01-01

    Increasing the rated thermal power of an existing plant represents a particularly profitable way for a plant operator to increase electricity production. For PWR plants, a 5% increase in power can, in fact, generally be achieved without significantly modifying systems and equipments based upon the margin in the original design. Larger power increases can be achieved in the case of S.G. replacement. Based on recent analysis of a 3 loop PWR, 900 MWe, up to 12% power uprating is feasible with an appropriate replacement S.G. The general rule is to perform power uprating without significant increase of average primary temperature. This is mainly a result of consideration of S.G. tube corrosion, of fuel clad corrosion and of core safety margins (DNBR margins in particular). This paper will present a general overview of the analyses for large power uprating: program of work, main conclusions on the following items: 1. Safety demonstration (accident analysis, safeguard systems capacity verification, required protection setpoints modifications...) 2. Normal operation review (possible consequences of power uprating on the plant maneuverability and on the fuel management performances) 3. Systems and components mechanical integrity review and potential effect on the plant lifetime of the new operating conditions

  3. Offers

    CERN Multimedia

    Staff Association

    2012-01-01

    proposes the following offer: 15% discount for the Staff Association members who enroll their children in summer FUTUREKIDS activities. Extracurricular Activities For Your Children The FUTUREKIDS Geneva Learning Center is open 6 days a week and offers a selection of after-school extracurricular activities for children and teenagers (ages 5 to 16). In addition to teaching in its Learning Centers, Futurekids collaborates with many private schools in Suisse Romande (Florimont, Moser, Champittet, Ecole Nouvelle, etc.) and with the Département de l'Instruction Publique (DIP) Genève. Courses and camps are usually in French but English groups can be set up on demand. FUTUREKIDS Computer Camps (during school holidays) FUTUREKIDS Computer Camps are a way of having a great time during vacations while learning something useful, possibly discovering a new hobby or even, why not, a future profession. Our computer camps are at the forefront of technology. Themes are diverse and suit all ...

  4. Offers

    CERN Multimedia

    Staff Association

    2013-01-01

    FUTUREKIDS proposes 15% discount for the Staff Association members who enroll their children in FUTUREKIDS activities. New workshop for 12-15 year olds, on how to develop applications for Android phones. Easter activities calendar Extracurricular Activities For Your Children The FUTUREKIDS Geneva Learning Center is open 6 days a week and offers a selection of after-school extracurricular activities for children and teenagers (ages 5 to 16). In addition to teaching in its Learning Centers, Futurekids collaborates with many private schools in Suisse Romande (Florimont, Moser, Champittet, Ecole Nouvelle, etc.) and with the Département de l'Instruction Publique (DIP) Genève. Courses and camps are usually in French but English groups can be set up on demand. FUTUREKIDS Computer Camps (during school holidays) FUTUREKIDS Computer Camps are a way of having a great time during vacations while learning something useful, possibly discovering a new hobby or even, why not, a fut...

  5. Offer

    CERN Multimedia

    Staff Association

    2015-01-01

    RRP Communication organizes cultural events such as concerts, shows, sporting events. The members of the Staff Association profits from a reduction of 10 CHF per ticket. How to proceed: The ticket reservation is made by mail info@rrp.ch. You need to give the following information: Name of the show, and which date chosen Number of tickets, and category Name and surname Address Telephone number Mention “offer CERN”, and attach a photocopy of your Staff Association member card. After your reservation, you will be sent a copy with a payslip to the address mentioned above. Once paid, the members have the possibility to: pick up their ticket(s) from the cash register the evening of the show (opens 1 hour before the show) by showing their member card; receive the ticket(s) to the address indicated above, by registered mail, subject to an extra cost of 10CHF. Next show : More information at http://www.rrp.ch/

  6. Possibilities of roentgenological method

    International Nuclear Information System (INIS)

    Sivash, Eh.S.; Sal'man, M.M.

    1980-01-01

    Literary and experimental data on estimating possibilities of roentgenologic investigations using an electron optical amplifier, X-ray television and roentgen cinematography are generalized. Different methods of studying gastro-intestinal tract are compared. The advantage of the roentgenologic method over the endoscopic method after stomach resection is shown [ru

  7. Offers

    CERN Multimedia

    Staff Association

    2011-01-01

    Special offers for our members       Go Sport in Val Thoiry is offering 15% discount on all purchases made in the shop upon presentation of the Staff Association membership card (excluding promotions, sale items and bargain corner, and excluding purchases using Go Sport  and Kadéos gift cards. Only one discount can be applied to each purchase).  

  8. Offers

    CERN Multimedia

    Staff Association

    2012-01-01

    L'Occitane en Provence proposes the following offer: 10 % discount on all products in all L'Occitane shops in Metropolitan France upon presentation of your Staff Association membership card and a valid ID. This offer is valid only for one person, is non-transferable and cannot be combined with other promotions.

  9. Offers

    CERN Multimedia

    Staff Association

    2014-01-01

    New offers : Discover the theater Galpon in Geneva. The Staff Association is happy to offer to its members a discount of 8.00 CHF on a full-price ticket (tickets of 15.00 CHF instead of 22.00 CHF) so do not hesitate anymore (mandatory reservation by phone + 4122 321  21 76 as tickets are quickly sold out!). For further information, please see our website: http://staff-association.web.cern.ch/fr/content/th%C3%A9%C3%A2tre-du-galpon  

  10. Offer

    CERN Multimedia

    Staff Association

    2016-01-01

    CERN was selected and participated in the ranking "Best Employers" organized by the magazine Bilan. To thank CERN for its collaboration, the magazine offers a reduction to the subscription fee for all employed members of personnel. 25% off the annual subscription: CHF 149.25 instead of CHF 199 .— The subscription includes the magazine delivered to your home for a year, every other Wednesday, as well as special editions and access to the e-paper. To benefit from this offer, simply fill out the form provided for this purpose. To get the form, please contact the secretariat of the Staff Association (Staff.Association@cern.ch).

  11. Offers

    CERN Multimedia

    Staff Association

    2013-01-01

    SPECIAL OFFER FOR OUR MEMBERS Prices Spring and Summer 2013 Day ticket: same price weekends, public holidays and weekdays: Children from 5 to 15 years old: 30 CHF instead of 39 CHF Adults from 16 years old: 36 CHF instead of 49 CHF Bonus! Free for children under 5 Tickets available at the Staff Association Secretariat.

  12. Offers

    CERN Multimedia

    Association du personnel

    2013-01-01

    SPECIAL OFFER FOR OUR MEMBERS Prices Spring and Summer 2013 Day ticket: same price weekends, public holidays and weekdays: – Children from 5 to 15 years old: 30 CHF instead of 39 CHF – Adults from 16 years old: 36 CHF instead of 49 CHF – Bonus! Free for children under 5 Tickets available at the Staff Association Secretariat.

  13. Offers

    CERN Document Server

    Staff Association

    2015-01-01

    New offer for our members. The Staff Association CERN staff has recently concluded a framework agreement with AXA Insurance Ltd, General-Guisan-Strasse 40, 8401 Winterthur. This contract allows you to benefit from a preferential tariff and conditions for insurances: Motor vehicles for passenger cars and motorcycles of the product line STRADA: 10% discount Household insurance (personal liability and household contents) the product line BOX: 10% discount Travel insurance: 10% discount Buildings: 10% discount Legal protection: 10% discount AXA is number one on the Swiss insurance market. The product range encompasses all non-life insurance such as insurance of persons, property, civil liability, vehicles, credit and travel as well as innovative and comprehensive solutions in the field of occupational benefits insurance for individuals and businesses. Finally, the affiliate AXA-ARAG (legal expenses insurance) completes the offer. Armed with your staff association CERN card, you can always get the off...

  14. Offer

    CERN Multimedia

    Staff Association

    2010-01-01

      Special offer for members of the Staff Association and their families 10% reduction on all products in the SEPHORA shop (sells perfume, beauty products etc.) in Val Thoiry ALL YEAR ROUND. Plus 20% reduction during their “vente privée”* three or four times a year. Simply present your Staff Association membership card when you make your purchase. * Next “vente privée” from 22th to 29th November 2010

  15. Offer

    CERN Multimedia

    Staff Association

    2011-01-01

      Special offer for members of the Staff Association and their families 10% reduction on all products in the SEPHORA shop (sells perfume, beauty products etc.) in Val Thoiry ALL YEAR ROUND. Plus 20% reduction during their “vente privée”* three or four times a year. Simply present your Staff Association membership card when you make your purchase. * Next “vente privée” from 25th to 27th March 2011  

  16. Offers

    CERN Multimedia

    Staff Association

    2012-01-01

    SPECIAL OFFER FOR OUR MEMBERS Single tariff Adulte/Enfant Tickets “Zone terrestre” 20 euros instead of 25 euros. Access to Aqualibi: 5 euros instead of 8 euros on presentation of your ticket SA member. Free for children under 3, with limited access to the attractions. More information on our website : http://association.web.cern.ch/association/en/OtherActivities/Walibi.html

  17. Offers

    CERN Multimedia

    Staff Association

    2012-01-01

    SPECIAL OFFER FOR OUR MEMBERS Prices Spring and Summer 2012 Half-day ticket: 5 hours, same price weekends, public holidays and weekdays. Children from 5 to 15 years old: 26 CHF instead of 35 CHF Adults from 16 years old: 32 CHF instead of 43 CHF Bonus! Free for children under 5. Aquaparc Les Caraïbes sur Léman 1807 Le Bouveret (VS)

  18. Offer

    CERN Multimedia

    CARLSON WAGONLIT TRAVEL

    2011-01-01

    Special offer   From 14th to 28th February 2011: no CWT service fee! For any new reservation of a holiday package (flight + hotel/apartment) from a catalog “summer 2011” For any additional information our staff is at your disposal from Monday – Friday, from 8h30 to 16h30. Phone number 72763 or 72797 Carlson Wagonlit Tavel, Agence du CERN  

  19. Offers

    CERN Document Server

    Staff Association

    2011-01-01

    Banque cantonale de Genève (BCGE) The BCGE Business partner programme devised for members of the CERN Staff Association offers personalized banking solutions with preferential conditions. The advantages are linked to salary accounts (free account keeping, internet banking, free Maestro and credit cards, etc.), mortgage lending, retirement planning, investment, credit, etc. The details of the programme and the preferential conditions are available on our website: http://association.web.cern.ch/association/en/OtherActivities/BCGE.html.  

  20. Offers

    CERN Multimedia

    Staff Association

    2012-01-01

    Special offer for members of the Staff Association and their families 10 % reduction on all products in the Sephora shop (sells perfume, beauty products etc.) in Val Thoiry all year round. Plus 20 % reduction during their “vente privée”* three or four times a year. Simply present your Staff Association membership card when you make your purchase. * next “vente privée” from 21st November to 1st December 2012 Please contact the Staff Association Secretariat to get the discount voucher.

  1. Offers

    CERN Multimedia

    Staff Association

    2012-01-01

    Special offer for members of the Staff Association and their families 10% reduction on all products in the SEPHORA shop (sells perfume, beauty products etc.) in Val Thoiry ALL YEAR ROUND. Plus 20% reduction during their “vente privée”* three or four times a year. Simply present your Staff Association membership card when you make your purchase. * Next “vente privée” from 21st to 26th May 2012 Please contact the Staff Association Secretariat to get the discount voucher  

  2. Offers

    CERN Multimedia

    Staff Association

    2013-01-01

    The « Théâtre de Carouge » offers a 5.- CHF discount for all shows (30.- CHF instead of 35.- CHF) and for the season tickets "Premières représentations" (132.- CHF instead of 162.- CHF) and "Classique" (150.- CHF instead of 180.- CHF). Please send your reservation by email to smills@tcag.ch via your professional email address. Please indicate the date of your reservation, your name and firstname and your telephone number A confirmation will be sent by email. Your membership card will be asked when you collect the tickets. More information on www.tcag.ch and www.tcag.ch/blog/

  3. Offers

    CERN Multimedia

    Staff Association

    2013-01-01

    Special offer for members of the Staff Association and their families 10 % reduction on all products in the SEPHORA shop (sells perfume, beauty products etc.) in Val Thoiry ALL YEAR ROUND. Plus 20 % reduction during their “vente privée”* three or four times a year. Simply present your Staff Association membership card when you make your purchase. * Next “vente privée” from 11th to 23rd November 2013 Please contact the Staff Association Secretariat to get the discount voucher.  

  4. Offers

    CERN Multimedia

    Staff Association

    2014-01-01

    Special offer for members of the Staff Association and their families 10 % reduction on all products in the SEPHORA shop (sells perfume, beauty products etc.) in Val Thoiry ALL YEAR ROUND. Simply present your Staff Association membership card when you make your purchase. Plus 20 % reduction during their “vente privée”* three or four times a year. * Next “vente privée” from 24th September to 6th November 2014 Please contact the Staff Association Secretariat to get the discount voucher.  

  5. Offers

    CERN Multimedia

    Staff Association

    2014-01-01

    Passeport Gourmand   Are you dying for a nice meal? The “Passeport Gourmand” offers discounted prices to the members of the Staff Association (available until April 2015 and on sale in the Staff Association Secretariat): Passeport gourmand Ain / Savoie/ Haute Savoie: 56 CHF instead of 79 CHF. Passeport gourmand Geneva / neighbouring France:72 CHF instead of 95 CHF. To the members of the Staff Association: Benefit of reduced tickets: CHF 10 (instead of  18 CHF at the desk) on sale to the secretariat of the Staff Association, Building 510-R010 (in front of the Printshop).

  6. Offers

    CERN Multimedia

    Staff Association

    2015-01-01

    New season 2015-2016 The new season was revealed in May, and was warmly welcomed by the press, which is especially enthusiastic about the exceptional arrival of Fanny Ardand in September in the framework of Cassandre show. Discover the programme 2015-2016. The theatre La Comédie proposes different offers to our members Benefit from a reduction of 20 % on a full price ticket during all the season: from 38 CHF to 23 CHF ticket instead of 50 CHF to 30 CHF depending on the show. Buy two seasonal tickets at the price of one (offers valid upon availability, and until 30 september 2015) 2 Cards Libertà for 240 CHF instead of 480 CHF. Cruise freely through the season with 8 perfomances of your choice per season. These cards are transferrable, and can be shared with one or more accompanying persons. 2 Abo Piccolo for 120 CHF instead of 240 CHF. Let yourself be surprised a theatre performance with our discovery seasonal tickets, which includes 4 flagship perfomances for the season. ...

  7. Offers

    CERN Multimedia

    Staff Association

    2011-01-01

    At the UN Cultural kiosk (door C6) This offer is meant for international civil servants, members of diplomatic missions as well as official delegates under presentation of their accreditation card. Matthew Lee & 5 musiciens Du Blues, du Boogie, du Rock’n’Roll 28 octobre 2011 à 20h30 Théâtre du Léman Quai du Mont-Blanc 19 Hôtel Kempinski Genève Matthew Lee is an exciting pianist singer combining classic Rock’n’Roll with timeless ballads. He revisits the standards, being alternately Jerry Lee Lewis, Chuck Berry, Little Richards and many others... He is a showman with a soulful voice and displays virtuosity during his piano solos. Simply amazing! 20 % reduction Tickets from 32 to 68 CHF Kiosque Culturel ONU Palais des Nations Porte 6 Avenue de la Paix 8-14 1211 Genève 10 Tél. 022 917 11 11 info@kiosqueonu.ch

  8. Offers

    CERN Multimedia

    Association du personnel

    2010-01-01

    THEATRE FORUM DE MEYRIN 1, place des Cinq-Continents 1217 Meyrin    Special offer for members of the Staff Association: Reduced ticket prices for the play Love is my sin (in English) from 15 to 17 March at 8.30pm http://www.forum-meyrin.ch/main.php?page=119&s=12   First category: 37 CHF instead of 46 CHF Second category (seats towards the sides): 30 CHF instead of 38 CHF Please present your CERN card and your Staff Association membership card at the ticket office. Ticket reservation: tel. 022 989 34 34 (from Monday to Friday 2pm to 6pm) or e-mail : billetterie@forum-meyrin.ch  

  9. Offers

    CERN Multimedia

    Staff Association

    2013-01-01

    Do not hesitate to benefit of our offers in our partners: Théâtre de Carouge Discount of 5 CHF for all shows (30 CHF instead of 35 CHF) and on season tickets « first performance » ( 132 CHF instead 162 CHF) and also on « classical » ( 150 CHF instead of 180 CHF) upon presentation of your Staff Association membership card before payment. Théâtre La Comédie de Genève  20% off on tickets (full price – also available for partner): from 24 to 32 CHF a ticket instead of 30 to 40 CHF depending on the shows. 40% off on annual subscriptions (access to the best seats, pick up tickets at the last minute): 200 CHF for 9 shows (about 22 CHF a ticket instead of 30 to 40 CHF. Discounted card: 60 CHF and single price ticket of 16 CHF.

  10. Offer

    CERN Document Server

    Staff Association

    2011-01-01

    DETAILS OF THE AGREEMENT WITH BCGE The BCGE Business partner programme devised for members of the CERN Staff Association offers personalized banking solutions with preferential conditions. The advantages are linked to salary accounts (free account keeping, internet banking, free Maestro and credit cards, etc.), mortgage lending, retirement planning, investment, credit, etc. The details of the programme and the preferential conditions are available on the Staff Association web site and from the secretariat (http://cern.ch/association/en/OtherActivities/BCGE.html). To benefit from these advantages, you will need to fill in the form available on our site, which must then be stamped by the Staff Association as proof that you are a paid-up member.  

  11. Offer

    CERN Multimedia

    Staff Association

    2016-01-01

    The “La Comédie” theatre unveiled its programme for the season 2016–2017 in late May, and it was met with great enthusiasm by the press. Leading names of the European and Swiss theatre scenes, such as director Joël Pommerat who recently won four Molière awards, will make an appearance! We are delighted to share this brand new, rich and varied programme with you. The “La Comédie” theatre has various discounts for our members Buy 2 subscriptions for the price of 1 : 2 cards “Libertà” for CHF 240.- instead of CHF 480.- Cruise freely through the season with an 8-entry card valid for the shows of your choice. These cards are transferable and can be shared with one or more accompanying persons. 2 cards “Piccolo” for CHF 120 instead of CHF 240.- This card lets you discover 4 shows which are suitable for all audiences (offers valid while stock lasts and until October 31, 20...

  12. Offers

    CERN Multimedia

    Staff Association

    2011-01-01

    Special offer for members of the Staff Association and their families 10% reduction on all products in the SEPHORA shop (sells perfume, beauty products etc.) in Val Thoiry ALL YEAR ROUND. Plus 20% reduction during their “vente privée”* three or four times a year. Simply present your Staff Association membership card when you make your purchase. * Next “vente privée” from 21st to 26th November 2011 New BCGE Business partner benefits As you may remember thanks to our BCGE business partner agreement you benefit from various advantages such as free annual subscription on your Silver or Gold credit card both for yourself and your partner (joint account). Please be informed that as of October 1st  2011 the below mentioned features will be added to your annual credit card subscription : MasterCard/Visa Silver and Gold: travel cancellation as well as related services such as holiday interruption best guaranteed price Only for Ma...

  13. Advances in Scientific Possibilities Offered by Real-Time Monitoring Technology.

    Science.gov (United States)

    Kleiman, Evan M; Nock, Matthew K

    2017-01-01

    There has been a marked increase in research aimed at studying dynamic (e.g., day-to-day, moment-to-moment) changes in mental disorders and related behavior problems. Indeed, the number of scientific papers published that focus on real-time monitoring has been nearly doubling every five years for the past several decades. These methods allow for a more fine-grained description of phenomena of interest as well as for real-world tests of theoretical models of human behavior. Here we comment on the recent study by van Winkel and colleagues (this issue)as an excellent example of the use of real-time monitoring methods to better understand mental disorders. We also discuss the expanding universe of new technologies (e.g., smartphones, wearable biosensors) that can be used to make discoveries about psychopathology and related constructs and describe what we perceive to be some of the most exciting scientific possibilities that can be achieved in the near term by taking advantage of these new and rapidly developing tools.

  14. Age, genesis and exploration for mineral deposits: the possibilities offered by lead isotopes

    International Nuclear Information System (INIS)

    Marcoux, E.; Calvez, J.Y.

    1985-01-01

    After a brief theoretical survey of the subject, the paper discusses the assistance that lead isotopes can bring to solving problems of metallogenesis and mineral exploration. Lead isotopes act as a true geologic clock when radioactive decay of lead takes place in a closed U-Th-Pb system, or when these conditions have been recreated by homogenization of a large crustal segment. The lead clock is thus reliable for deposits whose process of formation was part of a hydrothermal event that affected a significant part of the crust, most importantly in island-arc volcanosedimentary deposits, much less so for deposits formed by spatially restricted hydrothermal activity such as the emplacement of veins. Very interesting possibilities are also to be found in the capacity of lead isotopes to act as geochemical tracers. In conjunction with paragenetic and gitologic studies, determination of the isotopic composition of lead allows the sources of metals to be identified and permits an approach to the understanding of inheritance phenomena in a mineral deposit or province. This information also assists in unravelling the successive metallogenic processes in a region, thus contributing to refinement of the concept of a metallogenic province. Lastly lead isotopes provide an additional factor in assessing the economic potential of a deposit undergoing exploration. The method is based on a comparison of the isotopic signature of the deposit with that of economic mineralization occuring elsewhere in the circa. Examples of stratiform deposits and the gold-bearing veins of Limousin are described. The application of this method to gossans can provide additional information to standard geochemistry and thus assist in grading of targets [fr

  15. What can be offered to couples at (possibly) increased genetic risk?

    OpenAIRE

    Read, Andrew P.; Donnai, Dian

    2012-01-01

    We review the reasons why a couple might seek specialist genetic counselling about a possible reproductive risk and the options available to them. Most commonly, the couple will be concerned about the risk of recurrence of a medical condition that has already occurred in the family. Sometimes, the increased risk may come from their ethnicity or because of a consanguineous marriage, rather than because any problem has occurred previously. The geneticist must identify the exact nature of any pr...

  16. Analyzing the Magnetopause Internal Structure: New Possibilities Offered by MMS Tested in a Case Study

    Science.gov (United States)

    Rezeau, L.; Belmont, G.; Manuzzo, R.; Aunai, N.; Dargent, J.

    2018-01-01

    We explore the structure of the magnetopause using a crossing observed by the Magnetospheric Multiscale (MMS) spacecraft on 16 October 2015. Several methods (minimum variance analysis, BV method, and constant velocity analysis) are first applied to compute the normal to the magnetopause considered as a whole. The different results obtained are not identical, and we show that the whole boundary is not stationary and not planar, so that basic assumptions of these methods are not well satisfied. We then analyze more finely the internal structure for investigating the departures from planarity. Using the basic mathematical definition of what is a one-dimensional physical problem, we introduce a new single spacecraft method, called LNA (local normal analysis) for determining the varying normal, and we compare the results so obtained with those coming from the multispacecraft minimum directional derivative (MDD) tool developed by Shi et al. (2005). This last method gives the dimensionality of the magnetic variations from multipoint measurements and also allows estimating the direction of the local normal when the variations are locally 1-D. This study shows that the magnetopause does include approximate one-dimensional substructures but also two- and three-dimensional structures. It also shows that the dimensionality of the magnetic variations can differ from the variations of other fields so that, at some places, the magnetic field can have a 1-D structure although all the plasma variations do not verify the properties of a global one-dimensional problem. A generalization of the MDD tool is proposed.

  17. What can be offered to couples at (possibly) increased genetic risk?

    Science.gov (United States)

    Read, Andrew P; Donnai, Dian

    2012-07-01

    We review the reasons why a couple might seek specialist genetic counselling about a possible reproductive risk and the options available to them. Most commonly, the couple will be concerned about the risk of recurrence of a medical condition that has already occurred in the family. Sometimes, the increased risk may come from their ethnicity or because of a consanguineous marriage, rather than because any problem has occurred previously. The geneticist must identify the exact nature of any problem and determine the risks in the light of the mode of inheritance, any investigations undertaken and any other relevant information. The geneticist will then review the options open to the couple, and help them arrive at their own decision in a non-directive way. Some couples may opt to do nothing and let nature take its course but others may request prenatal or pre-implantation diagnosis, or they may avoid the conception of an at-risk child by using donor gametes, adoption or even decide not to have children.

  18. Possibilities of Particle Finite Element Methods in Industrial Forming Processes

    Science.gov (United States)

    Oliver, J.; Cante, J. C.; Weyler, R.; Hernandez, J.

    2007-04-01

    The work investigates the possibilities offered by the particle finite element method (PFEM) in the simulation of forming problems involving large deformations, multiple contacts, and new boundaries generation. The description of the most distinguishing aspects of the PFEM, and its application to simulation of representative forming processes, illustrate the proposed methodology.

  19. Possibilities and methods for mapping air pollution

    Energy Technology Data Exchange (ETDEWEB)

    LeBlanc, F

    1971-01-01

    For various reasons lichens seem to be much more sensitive to air pollution than flowering plants. Various methods to map the long-range effect of phytotoxicants on epiphytic lichens and mosses have been proposed. This paper outlines a few of these and proposes a new method. In Sudbury, Ontario, vegetation has been greatly affected by sulfur dioxide emanating from three huge smelters. The author shows that his map based on the response of lichens matches quite well with another map from the same area based on continuous SO/sub 2/ monitoring. The advantage of the biological map is that it took two weeks to accumulate the data required while the other one took ten years.

  20. Parental acceptability of contraceptive methods offered to their teen during a confidential health care visit.

    Science.gov (United States)

    Hartman, Lauren B; Shafer, Mary-Ann; Pollack, Lance M; Wibbelsman, Charles; Chang, Fay; Tebb, Kathleen P

    2013-02-01

    To examine parental acceptability of contraceptive methods offered confidentially to their adolescent daughter. A random sample of 261 parents/guardians with a daughter aged 12-17 years completed a telephone survey examining the relationship between parental acceptability of seven contraceptive methods and adolescents' likelihood to have sex, parenting beliefs, parents' sexual health as teens, sexually transmitted infection knowledge, and demographic factors. Acceptability was highest for oral contraceptive pills (59%) and lowest for intrauterine device (18%). Parental acceptance of teens' autonomy was significantly associated with increased acceptability of all methods. Parental knowledge of sexually transmitted infections was poor, and 51% found it acceptable for clinicians to provide their sexually active teen with condoms. Parents were more accepting of oral contraceptive pills and condoms compared with intrauterine devices and implants. Parental recognition of their teen's autonomy was associated with greater parental acceptability of clinicians providing their adolescent with contraceptives (regardless of the specific type of method being offered). Copyright © 2013 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  1. Determination of Tropical Forage Preferences Using Two Offering Methods in Rabbits

    Directory of Open Access Journals (Sweden)

    A. M. Safwat

    2014-04-01

    Full Text Available Two methods of feed preference trials were compared to evaluate the acceptability of 5 fresh foliages: Leucaena leucocephala, Moringa oleifera, Portulaca oleracea, Guazuma ulmifolia, and Brosimum alicastrum that was included as control. The evaluation included chemical analyses and forage intake by rabbits. The first method was a cafeteria trial; 12 California growing rabbits aged 8 wk, allocated in individual cages, were offered the five forage plants at the same time inside the cage, while in the second trial 60 California growing rabbits aged 8 wk, allocated individually, were randomly distributed into 5 experimental groups (n = 12/group; for each group just one forage species was offered at a time. The testing period for each method lasted for 7 d, preceded by one week of adaptation. The results showed that B. alicastrum and L. lecocephala were the most preferred forages while on the contrary G. ulmifolia was the least preferred one by rabbits. The results also revealed that the CV% value for the 2nd method (16.32%, which the tested forages were presented separately to rabbits, was lower and methodologically more acceptable than such value for the 1st method (34.28%, which all forages were presented together at the same time. It can be concluded that a range of tropical forages were consumed in acceptable quantities by rabbits, suggesting that diets based on such forages with a concentrate supplement could be used successfully for rabbit production. However, growth performance studies are still needed before recommendations could be made on appropriate ration formulations for commercial use.

  2. Danish method study on cervical screening in women offered HPV vaccination as girls (Trial23)

    DEFF Research Database (Denmark)

    Thamsborg, Lise Holst; Andersen, Berit; Larsen, Lise Grupe

    2018-01-01

    arm) or present screening plus an HPV test (HPV arm). The study started 1 February 2017 and will run over three screening rounds corresponding to 7-8 years. ANALYSES: The primary endpoint is cervical intraepithelial neoplasia grade 3 or above. The trial is undertaken as a non-inferiority study......INTRODUCTION: The first birth cohorts of women offered human papillomavirus (HPV) vaccination as girls are now entering cervical screening. However, there is no international consensus on how to screen HPV vaccinated women. These women are better protected against cervical cancer and could...... vaccination as girls. METHODS: Trial23 is a method study embedded in the existing cervical screening programme in four out of five Danish regions. Without affecting the screening programme, women born in 1994 are randomised to present screening with liquid-based cytology every third year (present programme...

  3. Selective extraction of actinides from high level liquid wastes. Study of the possibilities offered by the Redox properties of actinides

    International Nuclear Information System (INIS)

    Adnet, J.M.

    1991-07-01

    Partitioning of high level liquid wastes coming from nuclear fuel reprocessing by the PUREX process, consists in the elimination of minor actinides (Np, Am, and traces of Pu and U). Among the possible processes, the selective extraction of actinides with oxidation states higher than three is studied. First part of this work deals with a preliminary step; the elimination of the ruthenium from fission products solutions using the electrovolatilization of the RuO4 compound. The second part of this work concerns the complexation and oxidation reactions of the elements U, Np, Pu and Am in presence of a compound belonging to the insaturated polyanions family: the potassium phosphotungstate. For actinide ions with oxidation state (IV) complexed with phosphotungstate anion the extraction mechanism by dioctylamine was studied and the use of a chromatographic extraction technic permitted successful separations between tetravalents actinides and trivalents actinides. Finally, in accordance with the obtained results, the basis of a separation scheme for the management of fission products solutions is proposed

  4. THE STIMULATING OFFER OF RURAL TOURISM IN BUDA VILLAGE, BERZUNŢI COUNTY; POSSIBILITIES OF (READAPTATION REGARDING THE MODERN TOURIST PREFERENCES

    Directory of Open Access Journals (Sweden)

    GAMAN George

    2015-06-01

    Full Text Available Considering the fact that the village taken into study, like many Romanian settlements, faces with problems like depopulation and accelerated aging of local community, being unable to sustain an optimal agriculture, caused by shortcomings expansion of the industrialization process, the present paper aims to highlight the chances of rural tourism implementation, its possible effects and to realize a stimulative offer, readjusting it to the modern tourist preferences, through a rigorous analysis of primary and derived tourist offer by means of graphic, cartographic materials and through a survey application which aims to reveal the local community’s perception over rural tourism.

  5. PUBLIC PRIVATE PARTNERSHIP OFFERS NO MAGIC SOLUTIONS, BUT A METHOD FOR RESOLVING COMMUNITY NEEDS.

    Directory of Open Access Journals (Sweden)

    Pana Elena Cristina

    2015-07-01

    Full Text Available Public-private partnership (PPP is considered an important tool in financing public sector investments, its purpose being to provide more capital to invest in the most efficient manner. PPPs development has become more important as the economic and financial crisis has challenged the ability of the public bugets to raise adequate financial means and to allocate resources to specific projects. Local governments agree with the participation in realization of PPPs, which leads to increased efficiency, a shorter implementation and a value of the provision of services as large as possible. The advantages of implementing concern: appropriate sharing of risks and responsibilities; mainly public sector retains sovereign powers and the private sector has tasks requiring the implementation; private investment lifecycle as decisive elements of the forms of stimulation of PPP is long; it provides a long-term contractual relationship and offers innovation, in particular by specification of results, level of service and payment mechanisms . In the Member States of the European Union, the adoption of public-private partnership was made differently from one sector to another and from one country to another. At this point one can distinguish three types, namely: " Advanced PPP adopters" with very important projects in the transport sector (road, rail and in the construction of public buildings and equipment (schools, hospitals, prisons but also in the environment sector( water / waste treatment, waste management ; "Medium PPP adopters ", with projects completed or under execution and excellent results in the transport sector; " PPP adopters at a low level ", where PPP is lacking in all sectors and is in a preliminary stage of adoption. Great Britain, Spain and Romania are three countries and at the same time three levels of adopting, corresponding to the three types of PPP adopters. Although the partnership is thought as one which must bring benefits to both

  6. The Healthy Home Offerings via the Mealtime Environment (HOME) Plus study: Design and methods1

    Science.gov (United States)

    Fulkerson, Jayne A.; Neumark-Sztainer, Dianne; Story, Mary; Gurvich, Olga; Kubik, Martha Y.; Garwick, Ann; Dudovitz, Bonnie

    2014-01-01

    Background Informed and engaged parents and healthful home environments are essential for the health of youth. Although research has shown health benefits associated with family meals, to date, no randomized controlled trial (RCT) has been developed to examine the impact of a family meals intervention on behavioral and health outcomes. Methods/Design The Healthy Home Offerings via the Mealtime Environment (HOME) Plus study is a two-arm (intervention versus attention-only control) RCT being conducted in Minneapolis/St. Paul. Built on previous pilot research, HOME Plus aims to increase the frequency and healthfulness of family meals and snacks and reduce children’s sedentary behavior, particularly screen time, to promote healthier eating and activity behaviors and prevent obesity. HOME Plus is delivered to families in community settings. The program includes 10 monthly sessions focused on nutrition and activity education, meal planning and preparation skill development. In addition, five motivational goal-setting phone calls are conducted with parents. The primary outcome measure is age- and gender-adjusted child BMI-z score at post-intervention by treatment group. Secondary household-level outcomes include family meal frequency, home availability of healthful foods (fruits/vegetables) and unhealthful foods (high-fat/sugary snacks) and beverages (sugar-sweetened beverages), and the quality of foods served at meals and snacks. Secondary child outcomes include dietary intake of corresponding foods and beverages and screen time. Conclusions The HOME Plus RCT actively engages whole families of 8–12 year old children to promote healthier eating and activity behaviors and prevent obesity through promotion of family meals and snacks and limited media use. PMID:24480729

  7. Possible transfer of traditional energy intensive industries towards developing countries. Offers of energy resource in the CIER [Comision de Integracion Electrica Regional] area in relation to this transfer

    International Nuclear Information System (INIS)

    Facchini Ferro, A.; D'Amado Campo, R.

    1989-01-01

    Due to the steep rise in oil prices in the early 1970s, South American countries became aware of the advisability of developing their abundant and renewable hydroelectric resources. The second energy crisis of 1979 pushed up oil prices still further and the consequences in the South American electricity sector included contractions in markets, overcapacity, and difficult financial circumstances. Increases in exports were seen as a way to reduce the burden of those countries' heavy debts and to improve economic conditions. To harmonize the interests of development of highly energy intensive industries in developed countries and the economic development of developing countries, the possibility of marketing energy as an industrial input should be considered. Evidence of the advantages that South American countries can offer to such industrial transfers is presented. These countries offer a source of plentiful hydropower from installations in operation, under construction, or projected as major developments. These installations are already largely interconnected through high- and extra-high-voltage power transmission networks. Technical information is given on the installed generating capacities, including thermal reserve plants; utilization levels; transmission line interconnections; and remaining renewable and non-renewable energy resources. Considerations regarding the political and financial implications of industrial transfers are discussed. 6 refs., 9 figs

  8. The Healthy Home Offerings via the Mealtime Environment (HOME) Plus study: design and methods.

    Science.gov (United States)

    Fulkerson, Jayne A; Neumark-Sztainer, Dianne; Story, Mary; Gurvich, Olga; Kubik, Martha Y; Garwick, Ann; Dudovitz, Bonnie

    2014-05-01

    Informed and engaged parents and healthful home environments are essential for the health of youth. Although research has shown health benefits associated with family meals, to date, no randomized controlled trial (RCT) has been developed to examine the impact of a family meals intervention on behavioral and health outcomes. The Healthy Home Offerings via the Mealtime Environment (HOME) Plus study is a two-arm (intervention versus attention-only control) RCT being conducted in Minneapolis/St. Paul. Built on previous pilot research, HOME Plus aims to increase the frequency and healthfulness of family meals and snacks and reduce children's sedentary behavior, particularly screen time, to promote healthier eating and activity behaviors and prevent obesity. HOME Plus is delivered to families in community settings. The program includes 10 monthly sessions focused on nutrition and activity education, meal planning and preparation skill development. In addition, five motivational goal-setting phone calls are conducted with parents. The primary outcome measure is age- and gender-adjusted child BMI-z score at post-intervention by treatment group. Secondary household-level outcomes include family meal frequency, home availability of healthful foods (fruits/vegetables) and unhealthful foods (high-fat/sugary snacks) and beverages (sugar-sweetened beverages), and the quality of foods served at meals and snacks. Secondary child outcomes include dietary intake of corresponding foods and beverages and screen time. The HOME Plus RCT actively engages whole families of 8-12 year old children to promote healthier eating and activity behaviors and prevent obesity through promotion of family meals and snacks and limited media use. Copyright © 2014 Elsevier Inc. All rights reserved.

  9. Analysis of possible systematic errors in the Oslo method

    International Nuclear Information System (INIS)

    Larsen, A. C.; Guttormsen, M.; Buerger, A.; Goergen, A.; Nyhus, H. T.; Rekstad, J.; Siem, S.; Toft, H. K.; Tveten, G. M.; Wikan, K.; Krticka, M.; Betak, E.; Schiller, A.; Voinov, A. V.

    2011-01-01

    In this work, we have reviewed the Oslo method, which enables the simultaneous extraction of the level density and γ-ray transmission coefficient from a set of particle-γ coincidence data. Possible errors and uncertainties have been investigated. Typical data sets from various mass regions as well as simulated data have been tested against the assumptions behind the data analysis.

  10. Special Offers

    CERN Multimedia

    Association du personnel

    2011-01-01

    Walibi Rhône-Alpes is open until 31 October. Reduced prices for children and adults at this French attraction park in Les Avenières. For more information about all these offers, please consult our web site: http://association.web.cern.ch/association/en/OtherActivities/Offers.html

  11. Non-surgical sterilisation methods may offer a sustainable solution to feral horse (Equus caballus) overpopulation.

    Science.gov (United States)

    Hall, Sally Elizabeth; Nixon, Brett; Aitken, R John

    2017-09-01

    Feral horses are a significant pest species in many parts of the world, contributing to land erosion, weed dispersal and the loss of native flora and fauna. There is an urgent need to modify feral horse management strategies to achieve public acceptance and long-term population control. One way to achieve this is by using non-surgical methods of sterilisation, which are suitable in the context of this mobile and long-lived species. In this review we consider the benefits of implementing novel mechanisms designed to elicit a state of permanent sterility (including redox cycling to generate oxidative stress in the gonad, random peptide phage display to target non-renewable germ cells and the generation of autoantibodies against proteins essential for conception via covalent modification) compared with that of traditional immunocontraceptive approaches. The need for a better understanding of mare folliculogenesis and conception factors, including maternal recognition of pregnancy, is also reviewed because they hold considerable potential in providing a non-surgical mechanism for sterilisation. In conclusion, the authors contend that non-surgical measures that are single shot and irreversible may provide a sustainable and effective strategy for feral horse control.

  12. Special offers

    CERN Multimedia

    Staff Association

    2011-01-01

    Are you a member of the Staff Association? Did you know that as a member you can benefit from the following special offers: BCGE (Banque Cantonale de Genève): personalized banking solutions with preferential conditions. TPG: reduced rates on annual transport passes for active and retired staff. Aquaparc: reduced ticket prices for children and adults at this Swiss waterpark in Le Bouveret. FNAC: 5% reduction on FNAC vouchers. For more information about all these offers, please consult our web site: http://association.web.cern.ch/association/en/OtherActivities/Offers.html

  13. Special Offers

    CERN Multimedia

    Association du personnel

    2011-01-01

    Are you a member of the Staff Association? Did you know that as a member you can benefit from the following special offers: BCGE (Banque Cantonale de Genève): personalized banking solutions with preferential conditions. TPG: reduced rates on annual transport passes for active and retired staff. Aquaparc: reduced ticket prices for children and adults at this Swiss waterpark in Le Bouveret. Walibi: reduced prices for children and adults at this French attraction park in Les Avenières. FNAC: 5% reduction on FNAC vouchers. For more information about all these offers, please consult our web site: http://association.web.cern.ch/association/en/OtherActivities/Offers.html

  14. Conventional cable testing methods: strengths, weaknesses and possibilities

    International Nuclear Information System (INIS)

    Reynolds, P.H.

    1988-01-01

    The paper reviews the major conventional methods that can be used to test power plant cables. It assesses their usefulness in diagnosing the condition of the insulation of the cable and then proposes some possible directions for innovation. The methods examined are dc insulation resistance measurement, ac signal injection for continuous monitoring and fault location, and the ac measurement of capacitance and loss angle. Specific subjects considered are the effects of temperature, cable construction and installation, and the validity of insulation resistance or loss angle measurement. The innovative proposals refer to the use of automation in the measurement and of computer-based Expert Systems for the evaluation of the results

  15. Offers INTERSOCCER

    CERN Multimedia

    Staff Association

    2014-01-01

      Summer Football camps   New offer to the members of the Staff Association – INTERSOCCER: 12% discount on summer football camps and courses for children (bilingual) so do not hesitate anymore!    

  16. Alternative containment integrity test methods, an overview of possible techniques

    International Nuclear Information System (INIS)

    Spletzer, B.L.

    1986-01-01

    A study is being conducted to develop and analyze alternative methods for testing of containment integrity. The study is focused on techniques for continuously monitoring containment integrity to provide rapid detection of existing leaks, thus providing greater certainty of the integrity of the containment at any time. The study is also intended to develop techniques applicable to the currently required Type A integrated leakage rate tests. A brief discussion of the range of alternative methods currently being considered is presented. The methods include applicability to all major containment types, operating and shutdown plant conditions, and quantitative and qualitative leakage measurements. The techniques are analyzed in accordance with the current state of knowledge of each method. The bulk of the techniques discussed are in the conceptual stage, have not been tested in actual plant conditions, and are presented here as a possible future direction for evaluating containment integrity. Of the methods considered, no single method provides optimum performance for all containment types. Several methods are limited in the types of containment for which they are applicable. The results of the study to date indicate that techniques for continuous monitoring of containment integrity exist for many plants and may be implemented at modest cost

  17. Special Offers

    CERN Multimedia

    Association du personnel

    2011-01-01

    Are you a member of the Staff Association? Did you know that as a member you can benefit from the following special offers: BCGE (Banque Cantonale de Genève): personalized banking solutions with preferential conditions.     TPG: reduced rates on annual transport passes for active and retired staff.     Aquaparc: reduced ticket prices for children and adults at this Swiss waterpark in Le Bouveret.     Walibi: reduced prices for children and adults at this French attraction park in Les Avenières.       FNAC: 5% reduction on FNAC vouchers.       For more information about all these offers, please consult our web site: http://association.web.cern.ch/association/en/OtherActivities/Offers.html

  18. Special Offers

    CERN Multimedia

    Staff Association

    2011-01-01

    Are you a member of the Staff Association? Did you know that as a member you can benefit from the following special offers: BCGE (Banque Cantonale de Genève): personalized banking solutions with preferential conditions.     TPG: reduced rates on annual transport passes for all active and retired staff.     Aquaparc: reduced ticket prices for children and adults at this Swiss waterpark in Le Bouveret.     Walibi: reduced prices for children and adults at this French attraction park in Les Avenières.       FNAC: 5% reduction on FNAC vouchers.       For more information about all these offers, please consult our web site: http://association.web.cern.ch/association/en/OtherActivities/Offers.html

  19. Special offer

    CERN Multimedia

    Staff Association

    2010-01-01

    Special offer for members of the Staff Association and their families 10% reduction on all products in the SEPHORA shop (sells perfume, beauty products etc.) in Val Thoiry ALL YEAR ROUND. Plus 20% reduction during their “vente privée”* three or four times a year. Simply present your Staff Association membership card when you make your purchase. * next “vente privée” from 24th to 29th May 2010  

  20. Special offer

    CERN Multimedia

    Staff Association

    2011-01-01

    SPECIAL OFFER FOR OUR MEMBERS Tarif unique Adulte/Enfant Entrée Zone terrestre 19 euros instead of 23 euros Entrée “Zone terrestre + aquatique” 24 euros instead of 31 euros Free for children under 3, with limited access to the attractions. Walibi Rhône-Alpes is open daily from 22 June to 31 August, and every week end from 3 September until 31 October. Closing of the “zone aquatique” 11 September.

  1. Effects of forage offering method on performance, rumen fermentation, nutrient digestibility and nutritional behaviour in Holstein dairy calves.

    Science.gov (United States)

    EbnAli, A; Khorvash, M; Ghorbani, G R; Mahdavi, A H; Malekkhahi, M; Mirzaei, M; Pezeshki, A; Ghaffari, M H

    2016-10-01

    The potential effect of dietary forage supplementation on the performance and rumen development in dairy calves is well established. However, limited research has been directed to the comparative effects of forage offering methods on calf performance. The objective of the present study was to determine the effects of forage provision methods (total mixed ration or free choice) on the performance, nutrient digestibility, rumen fermentation and nutritional behaviour in newborn calves. Forty-five Holstein dairy calves (3 days of age and 41 ± 2 kg of body weight) were assigned to the following three groups (n = 15): (i) starter without forage provision (CON), (ii) starter supplemented with 10% alfalfa hay (AH) as a total mixed ration (AH-TMR) and (iii) starter and AH as a free-choice provision (AH-FC) for a period of 70 days. All the calves were offered 5 l of milk/day from day 3 to 50, and 2.5 l/day from day 50 until weaning on day 56. Dry matter intake (DMI) was greater (p forage tended (p = 0.08) to increase crude protein digestibility and overall volatile fatty acids (VFA) concentrations in the rumen. No differences were observed among the treatments at the time spent on standing, lying, eating and performing non-nutritive oral behaviours. Compared to CON calves, animals in the AH-TMR treatment spent more time (p forage supplementation in both forage offering methods increased total DMI, ruminal pH and ruminating time in dairy calves. Hence, there is no benefit in the free-choice provision of AH in dairy calves. Journal of Animal Physiology and Animal Nutrition © 2016 Blackwell Verlag GmbH.

  2. Danish method study on cervical screening in women offered HPV vaccination as girls (Trial23): a study protocol.

    Science.gov (United States)

    Thamsborg, Lise Holst; Andersen, Berit; Larsen, Lise Grupe; Christensen, Jette; Johansen, Tonje; Hariri, Jalil; Christiansen, Sanne; Rygaard, Carsten; Lynge, Elsebeth

    2018-05-26

    The first birth cohorts of women offered human papillomavirus (HPV) vaccination as girls are now entering cervical screening. However, there is no international consensus on how to screen HPV vaccinated women. These women are better protected against cervical cancer and could therefore be offered less intensive screening. Primary HPV testing is more sensitive than cytology, allowing for a longer screening interval. The aim of Trial23 is to investigate if primary HPV testing with cytology triage of HPV positive samples is a reasonable screening scheme for women offered HPV vaccination as girls. Trial23 is a method study embedded in the existing cervical screening programme in four out of five Danish regions. Without affecting the screening programme, women born in 1994 are randomised to present screening with liquid-based cytology every third year (present programme arm) or present screening plus an HPV test (HPV arm). The study started 1 February 2017 and will run over three screening rounds corresponding to 7-8 years. The primary endpoint is cervical intraepithelial neoplasia grade 3 or above. The trial is undertaken as a non-inferiority study including intention-to-treat and per-protocol analyses. The potential effect of primary HPV screening with a 6-year interval will be calculated from the observed data. The study protocol has been submitted to the ethical committee and deemed a method study. All women are screened according to routine guidelines. The study will contribute new evidence on the future screening of HPV vaccinated birth cohorts of women. All results will be published in open-access journal. NCT03049553; Pre-results. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  3. Toward a Buddhist Sociology: Theories, Methods, and Possibilities

    Science.gov (United States)

    Schipper, Janine

    2012-01-01

    This article explores potential links between Buddhism and sociology, highlighting the many commonalities between sociology and Buddhism, with an emphasis on ways that Buddhist thought and practice may contribute to the field of sociology. What could Buddhism offer to our understanding of social institutions, social problems, and to the dynamics…

  4. About possibilities using of theoretical calculation methods in radioecology

    International Nuclear Information System (INIS)

    Demoukhamedova, S.D.; Aliev, D.I.; Alieva, I.N.

    2002-01-01

    Full text: Increasing the radiation level into environment is accompanied by accumulation of radioactive compounds into organism and/or their migration into biosphere. Radiotoxins are accumulated into irradiated plants and animals in result of violation of exchanging processes. The are play an important role at the pathogenesis of irradiation. To date, there is well known that even small quantity of the pesticides capable intensified the radiation effect. To understand the mechanism of radiation effect on physiologically active compounds and their complexes, the knowledge of such molecules three-dimensional organization and electron structure is essential. This work is devoted to study the pesticides of carbamate range, i.e. 'sevin' and its derivatives the physiological activity of which has been connected with cholinesterase degradation. Spatial organization and conformational possibilities of the pesticides has been studied using a method of the theoretical conformational analysis on the base of computational program worked out in laboratory of Molecular Biophysics at the Baku State University. Quantum-chemical methods CNDO/2, AM1 and PM3 and complex programs 'LEV' were used in studies of electronic structures of 'sevin' and number of its analogues. Charge distribution on the atoms, optimization of geometrical electrooptic parameters, as well as molecular electrostatic potentials, electron density and nuclear forces were calculated. Visual maps and surface of valence electron density distribution in the given plane and surface of electron-nuclear forces distribution projection were constructed. The geometrical and energetic characteristics, charges on the atoms of investigated pesticides, as well as the maps and relief of the valence electron density distribution on the atoms have been received. According to calculation results, the changing of charge distribution in naphthalene ring is observed. The conclusion was made that the carbonyl group is essential for

  5. NEW POSSIBILITIES OF ENVIRONMENTALY FRIENDLY CLEANING METHOD BY LASER TECHNOLOGY

    Directory of Open Access Journals (Sweden)

    Lýdia Sobotová

    2016-12-01

    Full Text Available Still deteriorating environment, requirements for reducing of production waste, requirements for the protection of the working environment, the formation of new technologies and materials, as well as the economic conditions are forcing manufacturers to use the environmentally friendly technology. The contribution deals with new progressive possibilities of cleaning products, raw materials and with the establishment of a minimum production waste. The research focuses on the possibilities of laser cleaning of materials, under defined technological conditions. In the contribution is presented the results of realized experiments in Technical University of Kosice, together created in cooperation with Trumpf Slovakia, s.r.o

  6. Method for detecting clusters of possible uranium deposits

    International Nuclear Information System (INIS)

    Conover, W.J.; Bement, T.R.; Iman, R.L.

    1978-01-01

    When a two-dimensional map contains points that appear to be scattered somewhat at random, a question that often arises is whether groups of points that appear to cluster are merely exhibiting ordinary behavior, which one can expect with any random distribution of points, or whether the clusters are too pronounced to be attributable to chance alone. A method for detecting clusters along a straight line is applied to the two-dimensional map of 214 Bi anomalies observed as part of the National Uranium Resource Evaluation Program in the Lubbock, Texas, region. Some exact probabilities associated with this method are computed and compared with two approximate methods. The two methods for approximating probabilities work well in the cases examined and can be used when it is not feasible to obtain the exact probabilities

  7. On the Possibility of a Scientific Theory of Scientific Method.

    Science.gov (United States)

    Nola, Robert

    1999-01-01

    Discusses the philosophical strengths and weaknesses of Laudan's normative naturalism, which understands the principles of scientific method to be akin to scientific hypotheses, and therefore open to test like any principle of science. Contains 19 references. (Author/WRM)

  8. Possibilities of implementing nonthermal processing methods in the dairy industry

    OpenAIRE

    Irena Jeličić

    2010-01-01

    In the past two decades a lot of research in the field of food science has focused on new, non-thermal processing methods. This article describes the most intensively investigated new processing methodsfor implementation in the dairy industry, like microfiltration, high hydrostatic pressure, ultrasound and pulsed electric fields. For each method an overview is given for the principle of microbial inactivation, the obtained results regarding reduction of microorganisms as well as the positive ...

  9. The Quality Assessment of the Services Offered to the Students of the College of Education at King Saud University Using (SERVQUAL) Method

    Science.gov (United States)

    Alhabeeb, Abdurrahman Mohammad

    2015-01-01

    The goal of this study is measuring the level of quality service offered to students at the college of education at King Saud University, specifically the gap between students' perceptions and expectations of the quality of the offered service. The descriptive analytical approach has been applied in the study using SERVQUAL method to collect data…

  10. Possibilities and methods for biochemical assessment of radiation injury

    Energy Technology Data Exchange (ETDEWEB)

    Minkova, M [Meditsinska Akademiya, Sofia (Bulgaria). Nauchen Inst. po Rentgenologiya i Radiobiologiya

    1986-01-01

    An extensitive review (77 references) is made of the application of biochemical diagnostic methods for assessment of radiation diseases. A brief characteristics of several biochemical indicators is given: deoxycytidine, thymidine, rho-aminoisocarboxylic acid, DNA-ase, nucleic acids. Influence of such factors as age, sex, season etc. is studied by means of functional biochemical indicators as: creatine, triptophanic metabolites, 5-hydroxy-indolacetic acid, biogenic amines, serum proteins, enzymes, etc.

  11. Possibilities of implementing nonthermal processing methods in the dairy industry

    Directory of Open Access Journals (Sweden)

    Irena Jeličić

    2010-06-01

    Full Text Available In the past two decades a lot of research in the field of food science has focused on new, non-thermal processing methods. This article describes the most intensively investigated new processing methodsfor implementation in the dairy industry, like microfiltration, high hydrostatic pressure, ultrasound and pulsed electric fields. For each method an overview is given for the principle of microbial inactivation, the obtained results regarding reduction of microorganisms as well as the positive and undesirable effects on milk composition and characteristics. Most promising methods for further implementation in the dairy industry appeared to be combination of moderate temperatures with high hydrostatic pressure, respectively, pulsed electric fields and microfiltration, since those treatments did not result in any undesirable changes in sensory properties of milk. Additionally, milk treatment with these methodsresulted in a better milk fat homogenization, faster rennet coagulation, shorter duration of milk fermentations, etc. Very good results regarding microbial inactivation were obtained by treating milkwith combination of moderate temperatures and high intensity ultrasound which is also called a process of thermosonification. However, thermosonification treatments often result in undesirablechanges in milk sensory properties, which is most probably due to ultrasonic induced milk fat oxidation. This article also shortly describes the use of natural compounds with antimicrobial effects such as bacteriocins, lactoperoxidase system and lysozime. However their implementation is limited for reasons like high costs, interaction with other food ingredients, poor solubility, narrow activity spectrum, spontaneous loss of bacteriocinogenicity, etc. In addition, principles of antimicrobial effect of microwaves and ultraviolet irradiation are described. However their implementation in the dairy industry failed mostly due to technical and commercial reasons.

  12. Weighted mean: A possible method to express overall Dhatu Sarata

    Directory of Open Access Journals (Sweden)

    Chandar Prakash Gunawat

    2015-01-01

    Full Text Available Several questions are being raised regarding the accuracy of the methods of diagnosis and reporting of various clinical parameters according to Ayurveda in recent times. Uniformity in reporting, issues related to inter-rater variability, uniformity in applying statistical tests, reliability, consistency, and validation of various tools, - are some of the major concerns that are being voiced. Dhatu Sarata is one such domain where no substantial work has been carried out to address these issues. The Sanskrit term "Dhatu" roughly translates as a "tissue.". Sarata stands for the status of Dhatu in a given individual, i.e., it describes whether the status is excellent, moderate, or poor. In the available research literature, there are several gaps while dealing with and reporting the clinical assessment of Dhatu. Most of the workers group an individual into any one of the categories of Dhatu Sarata, and this approach neglects the contribution of other Dhatus to the overall Sarata in that individual. In this communication, we propose the usefulness of "weighted mean" in expressing the overall Sarata in an individual. This gives the researcher a freedom of not classifying an individual into any one group of Sarata, while also simultaneously allowing him/her to retain the focus on the status of an individual Dhatu.

  13. Weighted mean: A possible method to express overall Dhatu Sarata.

    Science.gov (United States)

    Gunawat, Chandar Prakash; Singh, Girish; Patwardhan, Kishor; Gehlot, Sangeeta

    2015-01-01

    Several questions are being raised regarding the accuracy of the methods of diagnosis and reporting of various clinical parameters according to Ayurveda in recent times. Uniformity in reporting, issues related to inter-rater variability, uniformity in applying statistical tests, reliability, consistency, and validation of various tools, - are some of the major concerns that are being voiced. Dhatu Sarata is one such domain where no substantial work has been carried out to address these issues. The Sanskrit term "Dhatu" roughly translates as a "tissue." Sarata stands for the status of Dhatu in a given individual, i.e., it describes whether the status is excellent, moderate, or poor. In the available research literature, there are several gaps while dealing with and reporting the clinical assessment of Dhatu. Most of the workers group an individual into any one of the categories of Dhatu Sarata, and this approach neglects the contribution of other Dhatus to the overall Sarata in that individual. In this communication, we propose the usefulness of "weighted mean" in expressing the overall Sarata in an individual. This gives the researcher a freedom of not classifying an individual into any one group of Sarata, while also simultaneously allowing him/her to retain the focus on the status of an individual Dhatu.

  14. Paradigms, pragmatism and possibilities: mixed-methods research in speech and language therapy.

    Science.gov (United States)

    Glogowska, Margaret

    2011-01-01

    After the decades of the so-called 'paradigm wars' in social science research methodology and the controversy about the relative place and value of quantitative and qualitative research methodologies, 'paradigm peace' appears to have now been declared. This has come about as many researchers have begun to take a 'pragmatic' approach in the selection of research methodology, choosing the methodology best suited to answering the research question rather than conforming to a methodological orthodoxy. With the differences in the philosophical underpinnings of the two traditions set to one side, an increasing awareness, and valuing, of the 'mixed-methods' approach to research is now present in the fields of social, educational and health research. To explore what is meant by mixed-methods research and the ways in which quantitative and qualitative methodologies and methods can be combined and integrated, particularly in the broad field of health services research and the narrower one of speech and language therapy. The paper discusses the ways in which methodological approaches have already been combined and integrated in health services research and speech and language therapy, highlighting the suitability of mixed-methods research for answering the typically multifaceted questions arising from the provision of complex interventions. The challenges of combining and integrating quantitative and qualitative methods and the barriers to the adoption of mixed-methods approaches are also considered. The questions about healthcare, as it is being provided in the 21st century, calls for a range of methodological approaches. This is particularly the case for human communication and its disorders, where mixed-methods research offers a wealth of possibilities. In turn, speech and language therapy research should be able to contribute substantively to the future development of mixed-methods research. © 2010 Royal College of Speech & Language Therapists.

  15. Analysis of the Possibility to Organize the Management Accounting through the Target Costing (TC Method in the Romanian Entities

    Directory of Open Access Journals (Sweden)

    Sorinel CĂPUŞNEANU

    2011-09-01

    Full Text Available This article presents a way of organizing the management accounting and cost calculation through the Target Costing method. There are treated the development stages of Target Costing method, and the role of the management accountant in the development and implementation of this method. The causes behind the choice to adapt the principles of Target Costing method to the Romanian General Accounting Plan and the operation of accounts used in highlighting economic and financial operations at the entity leve have been analyzedl. There are treated theoretical and applied the methodological steps taken in the management accounting and cost calculation. The article ends with the conclusions of the authors about the possibility of adapting the principles of Target Costing method to the Romanian General Accounting Plan and the advantages offered by this method.

  16. Manipulation-free cultures of human iPSC-derived cardiomyocytes offer a novel screening method for cardiotoxicity.

    Science.gov (United States)

    Rajasingh, Sheeja; Isai, Dona Greta; Samanta, Saheli; Zhou, Zhi-Gang; Dawn, Buddhadeb; Kinsey, William H; Czirok, Andras; Rajasingh, Johnson

    2018-04-05

    Induced pluripotent stem cell (iPSC)-based cardiac regenerative medicine requires the efficient generation, structural soundness and proper functioning of mature cardiomyocytes, derived from the patient's somatic cells. The most important functional property of cardiomyocytes is the ability to contract. Currently available methods routinely used to test and quantify cardiomyocyte function involve techniques that are labor-intensive, invasive, require sophisticated instruments or can adversely affect cell vitality. We recently developed optical flow imaging method analyses and quantified cardiomyocyte contractile kinetics from video microscopic recordings without compromising cell quality. Specifically, our automated particle image velocimetry (PIV) analysis of phase-contrast video images captured at a high frame rate yields statistical measures characterizing the beating frequency, amplitude, average waveform and beat-to-beat variations. Thus, it can be a powerful assessment tool to monitor cardiomyocyte quality and maturity. Here we demonstrate the ability of our analysis to characterize the chronotropic responses of human iPSC-derived cardiomyocytes to a panel of ion channel modulators and also to doxorubicin, a chemotherapy agent with known cardiotoxic side effects. We conclude that the PIV-derived beat patterns can identify the elongation or shortening of specific phases in the contractility cycle, and the obtained chronotropic responses are in accord with known clinical outcomes. Hence, this system can serve as a powerful tool to screen the new and currently available pharmacological compounds for cardiotoxic effects.

  17. PlantSize Offers an Affordable, Non-destructive Method to Measure Plant Size and Color in Vitro

    Directory of Open Access Journals (Sweden)

    Dóra Faragó

    2018-02-01

    Full Text Available Plant size, shape and color are important parameters of plants, which have traditionally been measured by destructive and time-consuming methods. Non-destructive image analysis is an increasingly popular technology to characterize plant development in time. High throughput automatic phenotyping platforms can simultaneously analyze multiple morphological and physiological parameters of hundreds or thousands of plants. Such platforms are, however, expensive and are not affordable for many laboratories. Moreover, determination of basic parameters is sufficient for most studies. Here we describe a non-invasive method, which simultaneously measures basic morphological and physiological parameters of in vitro cultured plants. Changes of plant size, shape and color is monitored by repeated photography with a commercial digital camera using neutral white background. Images are analyzed with the MatLab-based computer application PlantSize, which simultaneously calculates several parameters including rosette size, convex area, convex ratio, chlorophyll and anthocyanin contents of all plants identified on the image. Numerical data are exported in MS Excel-compatible format. Subsequent data processing provides information on growth rates, chlorophyll and anthocyanin contents. Proof-of-concept validation of the imaging technology was demonstrated by revealing small but significant differences between wild type and transgenic Arabidopsis plants overexpressing the HSFA4A transcription factor or the hsfa4a knockout mutant, subjected to different stress conditions. While HSFA4A overexpression was associated with better growth, higher chlorophyll and lower anthocyanin content in saline conditions, the knockout hsfa4a mutant showed hypersensitivity to various stresses. Morphological differences were revealed by comparing rosette size, shape and color of wild type plants with phytochrome B (phyB-9 mutant. While the technology was developed with Arabidopsis plants

  18. Tackling the workforce crisis in district nursing: can the Dutch Buurtzorg model offer a solution and a better patient experience? A mixed methods case study.

    Science.gov (United States)

    Drennan, Vari M; Calestani, Melania; Ross, Fiona; Saunders, Mary; West, Peter

    2018-06-06

    Despite policy intentions for more healthcare out of hospital, district nursing services face multiple funding and staffing challenges, which compromise the care delivered and policy objectives. What is the impact of the adapted Buurtzorg model on feasibility, acceptability and effective outcomes in an English district nursing service? Mixed methods case study. Primary care. Neighbourhood nursing team (Buurtzorg model), patients and carers, general practitioners (GPs), other health professionals, managers and conventional district nurses. The adapted Buurtzorg model of community nursing demonstrated feasibility and acceptability to patients, carers, GPs and other health professionals. For many patients, it was preferable to previous experiences of district nursing in terms of continuity in care, improved support of multiple long-term conditions (encompassing physical, mental and social factors) and proactive care. For the neighbourhood nurses, the ability to make operational and clinical decisions at team level meant adopting practices that made the service more responsive, accessible and efficient and offered a more attractive working environment. Challenges were reported by nurses and managers in relation to the recognition and support of the concept of self-managing teams within a large bureaucratic healthcare organisation. While there were some reports of clinical effectiveness and efficiency, this was not possible to quantify, cost or compare with the standard district nursing service. The adapted Buurtzorg model of neighbourhood nursing holds potential for addressing issues of concern to patients, carers and staff in the community. The two interacting innovations, that is, a renewed focus on patient and carer-centred care and the self-managing team, were implemented in ways that patients, carers, other health professionals and nurses could identify difference for both the nursing care and also the nurses' working lives. It now requires longer term

  19. Awareness of doctors of health care and possible therapy methods for alcohol and drug dependant patients in Latvia

    Directory of Open Access Journals (Sweden)

    Dave V.

    2012-10-01

    Full Text Available Aim is to investigate the knowledge of Latvian doctors about addiction treatment and healthcare possibilities in Latvia, to compare which methods are the best known to physicians, and which are offered to addicted patients. Work material and methods. Questionnaire was developed by researchers themselves, it contains 14 questions (about demographical data, treatment methods and their application. 250 questionnaires were distributed, 158 (63, 2% were received. Results. Average age of participants – 43.7 years. 31,0% of respondents are psychiatrists, 13,3% – addiction specialists, 34,8% – other specialists (general practitioners, internists, health care doctors, neurologists and others, 12,0% – psychotherapists, 4,4% – surgeons, 1,9% – dentists and 1,9% – paediatricians. The best known were detoxification (98,2% and suggestion (892% methods. The least known methods for drug addicts were substitution therapy (73,4% and rehabilitation communities (73,4%. The most recommended treatment method was Minnesota programme – 108 (68,4% and detoxification 99 (62,7%, the least recommended – substitution therapy – 29 (18,5%. Conclusions. 17,1% of respondents do not meet patients with addiction problems, but 20,3% of respondents don’t recommend any of treatment methods. Although 73%-98% of respondents have information about treatment methods, only 18%-68% of respondents offer them.

  20. PARTIAL TRAINING METHOD FOR HEURISTIC ALGORITHM OF POSSIBLE CLUSTERIZATION UNDER UNKNOWN NUMBER OF CLASSES

    Directory of Open Access Journals (Sweden)

    D. A. Viattchenin

    2009-01-01

    Full Text Available A method for constructing a subset of labeled objects which is used in a heuristic algorithm of possible  clusterization with partial  training is proposed in the  paper.  The  method  is  based  on  data preprocessing by the heuristic algorithm of possible clusterization using a transitive closure of a fuzzy tolerance. Method efficiency is demonstrated by way of an illustrative example.

  1. Detection methods for legionellae. Possibilities and limitations of detection methods; Niet alle detectiemethoden geschikt voor legionellagroei. Mogelijkheden en beperkingen detectiemethoden

    Energy Technology Data Exchange (ETDEWEB)

    Scheffer, W.

    2011-06-15

    This article provides an overview of existing and new methods for detecting legionella in water. It offers insight in the characteristics and applications of existing and new detection methods. However, it is impossible to assess the value of alternative methods at the moment. That will require additional research. [Dutch] Een overzicht is gemaakt van bestaande en nieuwe methoden om legionella in water aan te tonen. Daarmee wordt inzicht verkregen in de kenmerken en toepassingsmogelijkheden van bestaande en nieuwe detectiemethoden. De waarde van alternatieve methoden in een installatie kan echter nog niet worden beoordeeld. Daarvoor is nader onderzoek nodig.

  2. Study of the possibilities of using nuclear methods for characterizing the surface region of glasses

    International Nuclear Information System (INIS)

    Hsiung, P.

    1983-01-01

    Following a review of the different methods used for the analysis of surfaces, we give a detailed description of charged particle elastic backscattering and the experimental devices. We then apply this method to the study of the lixiviation of borosilicate glasses in aqueous media and to the characterization of two heavy elements, cerium and thorium and their possible interaction in simple borosilicates [fr

  3. Introduction on microbiological and biological methods and their possible combination with other analytical techniques for the detection of irradiated food

    International Nuclear Information System (INIS)

    Leonardi, M.

    1991-01-01

    Food irradiation is a physical method of processing and preserving food. One of the main purposes of the application of this technology to food is to obtain specific biological effects on the treated foodstuff. Typical examples of these treatment effects are listed in the article. A whole range of techniques is at disposal of the analyst to assure the Quality Control (QC) of various foodstuffs. They are based on microbiological, organoleptical, chemical, biochemical, immunological and/or physical methods. In the case of irradiation preserved food the opinion of the writer is that very often only a combination of analytical methods can solve the problem of detection of irradiated foodstuffs and in particular in most cases this combination could be formed by a biological or microbiological method + a chemical or physical one. The meaning of these combination of techniques is manifold. Combining the advantages of a rapid screening method with those of a more refined, reliable, even if more time consuming one; offering the possibility to carry out the analysis for the control of irradiated foodstuffs to different kinds of food control laboratories, often equipped in a different way, are some of the most evident advantages. These methods are briefly explained. At present, none method seems promising for the quantitative determination of the irradiation dose. Moreover, some of the proposed methods can only give a good presumption of the irradiation treatment applied to particular foodstuffs. (18 refs)

  4. A Novel Centrifugation Method Using a Cell Salvage Device Offers an Alternative to the Use of Leukocyte-Depleting Filters for Autologous Blood Transfusions.

    Science.gov (United States)

    Barchilon, Michael; Gaspar, Cristina; Mexas, Angela; Nieter, Don

    2016-12-01

    Autotransfusion protocols often use the use of costly filters, such as leukocyte-depleting filters (LDFs), to minimize reinfusion of activated leukocytes and inflammatory mediators associated with reperfusion injury (RI). LDFs are used extensively in hospital settings; however, they represent an additional capital expenditure for hospitals, as well as a constraint on the reinfusion rate of blood products for health-care providers. We compared a commonly used LDF to a novel centrifugation method employing a widely used cell salvage device. Complete blood counts and enzyme-linked immunosorbent assays (ELISAs) measuring tumor necrosis factor-α (TNF-α) and interleukin-2 (IL-2) were performed to compare the efficacy of these methodologies. The LDF removed, on average, 94% of all leukocytes, including 96% of neutrophils. The centrifugation method removed, on average, 89% of all leukocytes, including 91% of neutrophils and resulted in a highly concentrated red blood cell product. Our results suggest both methods offer equivalent leukocyte reduction. TNF-α was also comparably reduced following our novel centrifugation method and the LDF method and IL-2 levels were undetectable in all samples. These results indicate our novel centrifugation method may preclude the need for a LDF during select autotransfusion applications.

  5. Innovative gas offers

    International Nuclear Information System (INIS)

    Sala, O.; Mela, P.; Chatelain, F.

    2007-01-01

    New energy offers are progressively made available as the opening of gas market to competition becomes broader. How are organized the combined offers: gas, electricity, renewable energies and energy services? What are the marketing strategies implemented? Three participants at this round table present their offer and answer these questions. (J.S.)

  6. Possible classification of the methods of operational research applicable in the field of defense

    Directory of Open Access Journals (Sweden)

    Mučibabić Spasoje

    2006-01-01

    Full Text Available The overall dynamic development of operational research in various fields of human activities urges the need for a clearer and mathematically more explicit classification of its methods. This need is also very urgent in the field of defense, particularly because of the complications of modern conflicts, as well as of new security requirements. One of the possible classifications of methods based on the theory of games as a mathematical model for solving conflict situations is presented in this paper. The connections between methods and their mathematical description are underlined.

  7. Time-of-Flight Measurements as a Possible Method to Observe Anyonic Statistics

    Science.gov (United States)

    Umucalılar, R. O.; Macaluso, E.; Comparin, T.; Carusotto, I.

    2018-06-01

    We propose a standard time-of-flight experiment as a method for observing the anyonic statistics of quasiholes in a fractional quantum Hall state of ultracold atoms. The quasihole states can be stably prepared by pinning the quasiholes with localized potentials and a measurement of the mean square radius of the freely expanding cloud, which is related to the average total angular momentum of the initial state, offers direct signatures of the statistical phase. Our proposed method is validated by Monte Carlo calculations for ν =1 /2 and 1 /3 fractional quantum Hall liquids containing a realistic number of particles. Extensions to quantum Hall liquids of light and to non-Abelian anyons are briefly discussed.

  8. A sequential fuzzy diagnosis method for rotating machinery using ant colony optimization and possibility theory

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Hao; Ping, Xueliang; Cao, Yi; Lie, Ke [Jiangnan University, Wuxi (China); Chen, Peng [Mie University, Mie (Japan); Wang, Huaqing [Beijing University, Beijing (China)

    2014-04-15

    This study proposes a novel intelligent fault diagnosis method for rotating machinery using ant colony optimization (ACO) and possibility theory. The non-dimensional symptom parameters (NSPs) in the frequency domain are defined to reflect the features of the vibration signals measured in each state. A sensitive evaluation method for selecting good symptom parameters using principal component analysis (PCA) is proposed for detecting and distinguishing faults in rotating machinery. By using ACO clustering algorithm, the synthesizing symptom parameters (SSP) for condition diagnosis are obtained. A fuzzy diagnosis method using sequential inference and possibility theory is also proposed, by which the conditions of the machinery can be identified sequentially. Lastly, the proposed method is compared with a conventional neural networks (NN) method. Practical examples of diagnosis for a V-belt driving equipment used in a centrifugal fan are provided to verify the effectiveness of the proposed method. The results verify that the faults that often occur in V-belt driving equipment, such as a pulley defect state, a belt defect state and a belt looseness state, are effectively identified by the proposed method, while these faults are difficult to detect using conventional NN.

  9. Possibilities and limitations of the kinetic plot method in supercritical fluid chromatography.

    Science.gov (United States)

    De Pauw, Ruben; Desmet, Gert; Broeckhoven, Ken

    2013-08-30

    Although supercritical fluid chromatography (SFC) is becoming a technique of increasing importance in the field of analytical chromatography, methods to compare the performance of SFC-columns and separations in an unbiased way are not fully developed. The present study uses mathematical models to investigate the possibilities and limitations of the kinetic plot method in SFC as this easily allows to investigate a wide range of operating pressures, retention and mobile phase conditions. The variable column length (L) kinetic plot method was further investigated in this work. Since the pressure history is identical for each measurement, this method gives the true kinetic performance limit in SFC. The deviations of the traditional way of measuring the performance as a function of flow rate (fixed back pressure and column length) and the isopycnic method with respect to this variable column length method were investigated under a wide range of operational conditions. It is found that using the variable L method, extrapolations towards other pressure drops are not valid in SFC (deviation of ∼15% for extrapolation from 50 to 200bar pressure drop). The isopycnic method provides the best prediction but its use is limited when operating closer towards critical point conditions. When an organic modifier is used, the predictions are improved for both methods with respect to the variable L method (e.g. deviations decreases from 20% to 2% when 20mol% of methanol is added). Copyright © 2013 Elsevier B.V. All rights reserved.

  10. STUDY CONCERNING THE POSSIBILITY OF GAMMA-SPECTROSCOPY METHOD TO DETERMINE THE TOTAL POTASSIUM IN SOILS

    Directory of Open Access Journals (Sweden)

    Tamara Leah

    2011-12-01

    Full Text Available It was proved the possibility of determination the total potassium in soils by gamma-spectroscopic method with subsequent calculation of total potassium content in according to value of 40K isotope (expressed in Becquerel, Bq, using the formula: К2О, % = С . А, where: C – conversion coefficient, A – activity of isotope 40K in soil, Bq/kg. Conversion coefficient for chernozems of Moldova – C=0,00337.

  11. Possible generalization of the method of evolution in the coupling constant

    International Nuclear Information System (INIS)

    Belyaev, V.B.; Solovtsova, O.P.

    1980-01-01

    Two possible generalizations of the method of evolution in the coupling constant are presented. The consideration is given for a concrete case of the three-body problem: the πd scattering at the zeroth pion energy. It is shown that two approaches provide the value for the πd scattering length which is close to that obtained by solving the Faddeev equations [ru

  12. Possible application of underground leaching of uranium in ''sandstone'' deposits by drilling method

    International Nuclear Information System (INIS)

    Bareja, E.

    1988-01-01

    Underground leaching as the method for excavation of uranium from its sandstone deposits is applied in many countries. A preliminary examination of a possible use of this method to sandstone deposits in Poland suggests it to be analysed against the uranium mineralization, noted within sediments of the Lower Triassic age in the Peribaltic Syneclise in the Krynica Morska - Paslek area. Before a definite decision on such exploitation of uranium, geologic and hydrogeologic conditions should be studied of individual uranium-bearing beds, particularly their permeability and insulation by impermeable claystone series as well as extraction of uranium from its bearing sandstones. The depth at which uranium-bearing beds occur, forms a very important item. The depth at which uranium ores described in literature and exploited by this method occur, does not exceed 700 m. 7 refs. (author)

  13. On possibility of transuranium element by the method of transport reactions

    International Nuclear Information System (INIS)

    Sinitsyna, G.S.; Krashenitsyn, G.N.; Shestakov, B.I.

    1983-01-01

    A possibility to use chemical transport reaction for separation of uranium, plutonium and some transplutonium elements is shown. The method is based on the use of the known plutonium property to form tetrachloride existing only in the gaseous phase in chlorine atmosphere, which is transported ever the temperature gradiept. Two ways of transport reaction realization - the method of flow and the method of diffusion in closed volume are tested. The experiments are made using specially synthesized plutonium dioxide, containing uranium, americium, curium, lanthanum, terbium, barium. Chlorination is realized by the mixture of chlorine and carbon tetrachloride at temperatures 723-953 K. Plutonium trichloride is deposited in the range 613-653 K, uranium - in the range 473-523 K, curium, americium, lanthanum, terbium, barium remain in the start zone if its temperature does not exceed 873 K

  14. The FTA Method And A Possibility Of Its Application In The Area Of Road Freight Transport

    Directory of Open Access Journals (Sweden)

    Poliaková Adela

    2015-06-01

    Full Text Available The Fault Tree process utilizes logic diagrams to portray and analyse potentially hazardous events. Three basic symbols (logic gates are adequate for diagramming any fault tree. However, additional recently developed symbols can be used to reduce the time and effort required for analysis. A fault tree is a graphical representation of the relationship between certain specific events and the ultimate undesired event (2. This paper deals to method of Fault Tree Analysis basic description and provides a practical view on possibility of application by quality improvement in road freight transport company.

  15. The FTA Method And A Possibility Of Its Application In The Area Of Road Freight Transport

    Science.gov (United States)

    Poliaková, Adela

    2015-06-01

    The Fault Tree process utilizes logic diagrams to portray and analyse potentially hazardous events. Three basic symbols (logic gates) are adequate for diagramming any fault tree. However, additional recently developed symbols can be used to reduce the time and effort required for analysis. A fault tree is a graphical representation of the relationship between certain specific events and the ultimate undesired event (2). This paper deals to method of Fault Tree Analysis basic description and provides a practical view on possibility of application by quality improvement in road freight transport company.

  16. Teaching Research Methods and Statistics in eLearning Environments: Pedagogy, Practical Examples, and Possible Futures

    Science.gov (United States)

    Rock, Adam J.; Coventry, William L.; Morgan, Methuen I.; Loi, Natasha M.

    2016-01-01

    Generally, academic psychologists are mindful of the fact that, for many students, the study of research methods and statistics is anxiety provoking (Gal et al., 1997). Given the ubiquitous and distributed nature of eLearning systems (Nof et al., 2015), teachers of research methods and statistics need to cultivate an understanding of how to effectively use eLearning tools to inspire psychology students to learn. Consequently, the aim of the present paper is to discuss critically how using eLearning systems might engage psychology students in research methods and statistics. First, we critically appraise definitions of eLearning. Second, we examine numerous important pedagogical principles associated with effectively teaching research methods and statistics using eLearning systems. Subsequently, we provide practical examples of our own eLearning-based class activities designed to engage psychology students to learn statistical concepts such as Factor Analysis and Discriminant Function Analysis. Finally, we discuss general trends in eLearning and possible futures that are pertinent to teachers of research methods and statistics in psychology. PMID:27014147

  17. Teaching Research Methods and Statistics in eLearning Environments: Pedagogy, Practical Examples, and Possible Futures.

    Science.gov (United States)

    Rock, Adam J; Coventry, William L; Morgan, Methuen I; Loi, Natasha M

    2016-01-01

    Generally, academic psychologists are mindful of the fact that, for many students, the study of research methods and statistics is anxiety provoking (Gal et al., 1997). Given the ubiquitous and distributed nature of eLearning systems (Nof et al., 2015), teachers of research methods and statistics need to cultivate an understanding of how to effectively use eLearning tools to inspire psychology students to learn. Consequently, the aim of the present paper is to discuss critically how using eLearning systems might engage psychology students in research methods and statistics. First, we critically appraise definitions of eLearning. Second, we examine numerous important pedagogical principles associated with effectively teaching research methods and statistics using eLearning systems. Subsequently, we provide practical examples of our own eLearning-based class activities designed to engage psychology students to learn statistical concepts such as Factor Analysis and Discriminant Function Analysis. Finally, we discuss general trends in eLearning and possible futures that are pertinent to teachers of research methods and statistics in psychology.

  18. Tunnelling support methods and their possible application to machine rock face excavation in coal mining

    Energy Technology Data Exchange (ETDEWEB)

    Maidl, B.; Edeling, H.

    1981-06-11

    Mechanized pushing through the rocks is possible even in teary rock if protective measures are taken directly behind the drill bit. Present arch-type supports are best reinforced with sprayed concrete as it will take up rock deformations. In this case, however, the question soon arises whether arch-type steel supports should be used at all. So far, mature solutions have not been found but they will be possible if the mining industry is really interested. Sprayed concrete with admixtures of reinforcing steel fibers plays a major role here as it will protect miner's heads already at an early stage and is suitable as support even at a later stage. Equally interesting would be reinforced concrete pumped behind advancing formwork. A combination of both techniques may turn out to be the most suitable method to replace arch-type supports. A problem of particular importance is machine bracing in the fresh concrete lining. If the concrete is filled in directly behind the drill bit, it is only 4 to 6 h old when it reaches the bracing device, i.e., its pressure resistance is lower than the contact pressure of present mining machinery. It may be difficult to find a solution here but it is considered to be possible. With shell concrete, the formwork should be constructed so as to withstand the contact pressure.

  19. A possible method of carbon deposit mapping on plasma facing components using infrared thermography

    International Nuclear Information System (INIS)

    Mitteau, R.; Spruytte, J.; Vallet, S.; Travere, J.M.; Guilhem, D.; Brosset, C.

    2007-01-01

    The material eroded from the surface of plasma facing components is redeposited partly close to high heat flux areas. At these locations, the deposit is heated by the plasma and the deposition pattern evolves depending on the operation parameters. The mapping of the deposit is still a matter of intense scientific activity, especially during the course of experimental campaigns. A method based on the comparison of surface temperature maps, obtained in situ by infrared cameras and by theoretical modelling is proposed. The difference between the two is attributed to the thermal resistance added by deposited material, and expressed as a deposit thickness. The method benefits of elaborated imaging techniques such as possibility theory and fuzzy logics. The results are consistent with deposit maps obtained by visual inspection during shutdowns

  20. Possibility of determination of the Galaxy age by the method of uranium - thorium isotopic relations

    International Nuclear Information System (INIS)

    Lyutostanskij, Yu.S.; Malevannyj, S.V.; Panov, I.V.; Chechetkin, V.M.

    1988-01-01

    Calculations concerning the formation of heavy elements in an astrophysical fast nuclear process characteristics of the Supernova explosions are carried out in the kinetic model of nucleosynthesis. The age of the Galaxy T G has been calculated making use of the method of uranium-thorium isotopic relations supplemented with the data on 244 Pu abundance in meteorites. T G is shown to be strongly dependent upon the calculation method applied to production of nuclei in r process, upon the data on neutron-rich nuclei and as well upon the external conditions, i.e. the density and temperature in the explosing star. The possibility of nucleosynthesis takes place due to close Supernova explosion, which enriched the chemical content of earth matter with heavy elements is analyzed. The range of allowed values of parameters of the theory of nucleosynthesis is studied

  1. Possibility of applying the gamma-gamma method to the in situ determination of uranium-ore densities

    International Nuclear Information System (INIS)

    Czubek, J.; Guitton, J.

    1965-01-01

    The principles of the gamma-gamma method are reviewed. It is shown in particular that, under certain conditions, the method makes it possible to obtain a representative measurement of the electronic density. Chemical analyses have been carried out on samples obtained from uranium deposits. The results show that an exact correlation exists between the massive and electronic densities. It is possible to consider the possibility of measuring the density of uranium-containing rocks by the gamma-gamma method. (authors) [fr

  2. Screening possible solid electrolytes by calculating the conduction pathways using Bond Valence method

    Science.gov (United States)

    Gao, Jian; Chu, Geng; He, Meng; Zhang, Shu; Xiao, RuiJuan; Li, Hong; Chen, LiQuan

    2014-08-01

    Inorganic solid electrolytes have distinguished advantages in terms of safety and stability, and are promising to substitute for conventional organic liquid electrolytes. However, low ionic conductivity of typical candidates is the key problem. As connective diffusion path is the prerequisite for high performance, we screen for possible solid electrolytes from the 2004 International Centre for Diffraction Data (ICDD) database by calculating conduction pathways using Bond Valence (BV) method. There are 109846 inorganic crystals in the 2004 ICDD database, and 5295 of them contain lithium. Except for those with toxic, radioactive, rare, or variable valence elements, 1380 materials are candidates for solid electrolytes. The rationality of the BV method is approved by comparing the existing solid electrolytes' conduction pathways we had calculated with those from experiments or first principle calculations. The implication for doping and substitution, two important ways to improve the conductivity, is also discussed. Among them Li2CO3 is selected for a detailed comparison, and the pathway is reproduced well with that based on the density functional studies. To reveal the correlation between connectivity of pathways and conductivity, α/ γ-LiAlO2 and Li2CO3 are investigated by the impedance spectrum as an example, and many experimental and theoretical studies are in process to indicate the relationship between property and structure. The BV method can calculate one material within a few minutes, providing an efficient way to lock onto targets from abundant data, and to investigate the structure-property relationship systematically.

  3. Application possibility of the direct current conduction method for nondestructive crack measurement

    International Nuclear Information System (INIS)

    Riedl, R.

    1982-01-01

    An important value to determine the danger of cracks is the determination of crack depths. The crack depth can be determined quite accurate by means of the direct current conduction method, if one holds onto certain rules. Often complicated experimental set-ups are applied. However, portable commercial devices can be obtained that can be used for partial fluxation, that yield good results. By means of two examples: crack conduction samples in which the built-up of a constant-cracking is persued up to a certain depth, as well as the persuasion of an continuing crack in a bearing cylinder, shall be demonstrated that is very well possible to record accurate profiles with commercial devices and to avoid expensive measurement devices. (orig.) [de

  4. Offers for our members

    CERN Multimedia

    Staff Association

    2013-01-01

    The Courir shops propose the following offer: 15% discount on all articles (not on sales) in the Courir shops (Val Thoiry, Annemasse and Neydens) and 5% discount on sales upon presentation of your Staff Association membership card and an identity card before payment. Summer is here, enjoy our offers for the aquatic parcs! Walibi : Tickets "Zone terrestre": 21 € instead of 26 €. Access to Aqualibi: 5 € instead of 8 € on presentation of your SA member ticket. Free for children (3-11 years old) before 12 h 00. Free for children under 3, with limited access to the attractions. Car park free. * * * * * Aquaparc : Day ticket: – Children: 30 CHF instead of 39 CHF – Adults : 36 CHF instead of 49 CHF Bonus! Free for children under 5.

  5. Offers for our members

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    Summer is coming, enjoy our offers for the aquatic parcs! Walibi : Tickets "Zone terrestre": 25 € instead of 31 €. Access to Aqualibi: 5 € instead of 8 € on presentation of your Staff Association member ticket. Free for children under 100 cm. Car park free. * * * * * Aquaparc : Day ticket: – Children: 33 CHF instead of 39 CHF – Adults : 33 CHF instead of 49 CHF Bonus! Free for children under 5.  

  6. Offers for our members

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    Staff Association

    2017-01-01

    Summer is here, enjoy our offers for the aquatic parcs! Walibi : Tickets "Zone terrestre": 24 € instead of 30 €. Access to Aqualibi: 5 € instead of 6 € on presentation of your SA member ticket. Free for children under 100 cm. Car park free. * * * * * Aquaparc : Day ticket: – Children: 33 CHF instead of 39 CHF – Adults : 33 CHF instead of 49 CHF Bonus! Free for children under 5.

  7. Offers for our members

    CERN Multimedia

    Staff Association

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    Summer is coming, enjoy our offers for the aquatic parcs! Walibi : Tickets "Zone terrestre": 24 € instead of 30 €. Access to Aqualibi: 5 € instead of 6 € on presentation of your SA member ticket. Free for children under 100 cm. Car park free. * * * * * Aquaparc : Day ticket: – Children: 33 CHF instead of 39 CHF – Adults : 33 CHF instead of 49 CHF Bonus! Free for children under 5.

  8. Theoretical and Practical Studies on a Possible Genetic Method for Tsetse Fly Control

    Energy Technology Data Exchange (ETDEWEB)

    Curtis, C. F. [Tsetse Research Laboratory, School of Veterinary Science, University Of Bristol, Langford, Bristol (United Kingdom); Hill, W. G. [Institute of Animal Genetics, Edinburgh (United Kingdom)

    1968-06-15

    Chromosome translocations may be useful in pest control because they are a common type of mutation in a variety of organisms and, frequently, the heterozygote is semi-sterile and the homo- zygote folly fertile. It might be possible to induce such a translocation in a pest species, to breed from a selected ancestral pair of translocation homozygotes a large number of the homozygotes and to release these into a wild population. This would cause the production of heterozygotes in the wild population and hence would reduce the fertility of the population. This reduction would persist for a number of generations. Calculations, based on simplified assumptions, showed that this method of fertility reduction might be more economical than the use of sterilized males. In the present paper a theoretical comparison is made of the translocation and sterilized-male methods for the control of tsetse flies (Glossina sp.). A computer model has been set up which simulates, as far as possible, the known facts about birth, mating and death in a wild tsetse population. The predicted effects of releases of sterilized males and of translocation homozygotes are described and the modifications which would be caused by density-dependent mortality, migration and reduced viability of the translocation genotypes and sterilized males are indicated. It is concluded that to eradicate a well isolated wild population the numbers of translocation homozygotes required might well be considerably less than the number of sterilized males required for the same task. However, immigration into the population would greatly reduce the efficiency of the translocation method. The progress so far in attempting to produce a suitable translocation in Glossina austeni is described. Males have been treated with 5-7 krad of gamma radiation and a number of semi-sterile individuals have been selected from among their progeny. The semi-sterility is inherited and, by analogy with the results in other organisms, is

  9. A possible method for non-Hermitian and Non-PT-symmetric Hamiltonian systems.

    Directory of Open Access Journals (Sweden)

    Jun-Qing Li

    Full Text Available A possible method to investigate non-Hermitian Hamiltonians is suggested through finding a Hermitian operator η+ and defining the annihilation and creation operators to be η+ -pseudo-Hermitian adjoint to each other. The operator η+ represents the η+ -pseudo-Hermiticity of Hamiltonians. As an example, a non-Hermitian and non-PT-symmetric Hamiltonian with imaginary linear coordinate and linear momentum terms is constructed and analyzed in detail. The operator η+ is found, based on which, a real spectrum and a positive-definite inner product, together with the probability explanation of wave functions, the orthogonality of eigenstates, and the unitarity of time evolution, are obtained for the non-Hermitian and non-PT-symmetric Hamiltonian. Moreover, this Hamiltonian turns out to be coupled when it is extended to the canonical noncommutative space with noncommutative spatial coordinate operators and noncommutative momentum operators as well. Our method is applicable to the coupled Hamiltonian. Then the first and second order noncommutative corrections of energy levels are calculated, and in particular the reality of energy spectra, the positive-definiteness of inner products, and the related properties (the probability explanation of wave functions, the orthogonality of eigenstates, and the unitarity of time evolution are found not to be altered by the noncommutativity.

  10. On the possibility of non-invasive multilayer temperature estimation using soft-computing methods.

    Science.gov (United States)

    Teixeira, C A; Pereira, W C A; Ruano, A E; Ruano, M Graça

    2010-01-01

    This work reports original results on the possibility of non-invasive temperature estimation (NITE) in a multilayered phantom by applying soft-computing methods. The existence of reliable non-invasive temperature estimator models would improve the security and efficacy of thermal therapies. These points would lead to a broader acceptance of this kind of therapies. Several approaches based on medical imaging technologies were proposed, magnetic resonance imaging (MRI) being appointed as the only one to achieve the acceptable temperature resolutions for hyperthermia purposes. However, MRI intrinsic characteristics (e.g., high instrumentation cost) lead us to use backscattered ultrasound (BSU). Among the different BSU features, temporal echo-shifts have received a major attention. These shifts are due to changes of speed-of-sound and expansion of the medium. The originality of this work involves two aspects: the estimator model itself is original (based on soft-computing methods) and the application to temperature estimation in a three-layer phantom is also not reported in literature. In this work a three-layer (non-homogeneous) phantom was developed. The two external layers were composed of (in % of weight): 86.5% degassed water, 11% glycerin and 2.5% agar-agar. The intermediate layer was obtained by adding graphite powder in the amount of 2% of the water weight to the above composition. The phantom was developed to have attenuation and speed-of-sound similar to in vivo muscle, according to the literature. BSU signals were collected and cumulative temporal echo-shifts computed. These shifts and the past temperature values were then considered as possible estimators inputs. A soft-computing methodology was applied to look for appropriate multilayered temperature estimators. The methodology involves radial-basis functions neural networks (RBFNN) with structure optimized by the multi-objective genetic algorithm (MOGA). In this work 40 operating conditions were

  11. Offers for our members

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    Summer is here, enjoy our offers for the aquatic parcs! Walibi : Tickets "Zone terrestre": 21 € instead of 26 €. Access to Aqualibi: 5 € instead of 8 € on presentation of your SA member ticket. Free for children (3-11 years old) before 12 h 00. Free for children under 3, with limited access to the attractions. Car park free. * * * * * Aquaparc : Day ticket: – Children: 30 CHF instead of 39 CHF – Adults : 36 CHF instead of 49 CHF Bonus! Free for children under 5.

  12. Offers for our members

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    Summer is here, enjoy our offers for the aquatic parcs! Walibi : Tickets "Zone terrestre": 21,50 € instead of 27 €. Access to Aqualibi: 5 € instead of 6 € on presentation of your SA member ticket. Free for children (3-11 years old) before 12:00 p.m. Free for children under 3, with limited access to the attractions. Car park free. * * * * * Aquaparc : Day ticket: – Children: 33 CHF instead of 39 CHF – Adults : 33 CHF instead of 49 CHF Bonus! Free for children under 5.

  13. Offers for our members

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    Summer is here, enjoy our offers for the aquatic parcs! Walibi : Tickets "Zone terrestre": 23 € instead of 29 €. Access to Aqualibi: 5 € instead of 6 € on presentation of your SA member ticket. Free for children (3-11 years old) before 12:00 p.m. Free for children under 3, with limited access to the attractions. Car park free. * * * * * Aquaparc : Day ticket: – Children: 33 CHF instead of 39 CHF – Adults : 33 CHF instead of 49 CHF Bonus! Free for children under 5.

  14. Offers for our members

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    Summer is here, enjoy our offers for the water parks! Walibi: Tickets "Zone terrestre": 24 € instead of 30 €. Access to Aqualibi: 5 € instead of 6 € on presentation of your ticket purchased at the Staff Association. Bonus! Free for children under 100 cm, with limited access to the attractions. Free car park. *  *  *  *  *  *  *  * Aquaparc: Day ticket: -  Children: 33 CHF instead of 39 CHF -  Adults : 33 CHF instead of 49 CHF Bonus! Free for children under 5 years old.

  15. Project modepen: holistic educational model for the empowerment of the configuracional thought of the children and girls aged 0 to 10 by the possibilities offered by the learning process based on mathematical problems

    Directory of Open Access Journals (Sweden)

    Mileidy Salcedo Barragán

    2013-10-01

    Full Text Available In the educational work it is necessary the pedagogical practice is based on high levels of theoretical appropriation that allows the continuous improvement in terms of methods, procedures, and logically results that influence the learning of the child. Ownership of the content through problémica education favours creativity and logical thinking. The mental processes to reasoning, in order to obtain information and make decisions, compared with the purpose of mathematics in the curriculum guidelines are important, it considers that the knowledge of the area (their concepts and structures are a powerful tool for the development of thinking skills. Seen in this way, mathematical knowledge and teaching problémica become allies with common goals of teaching and learning.  

  16. Assessment of the Possibility of Using Reclaimed Materials for Making Cores by the Blowing Method

    Directory of Open Access Journals (Sweden)

    Dańko R.

    2017-03-01

    Full Text Available The cumulative results of investigations of the possibility of using the reclaimed materials after the mechanical, thermal or mechanical-thermal reclamation for making cores by means of the blowing method in the alkaline CO2 technology, are presented in the paper. Three kinds of spent sands: with furfuryl resin, bentonite and alkaline phenolic resin, obtained from the foundry, were subjected to three kinds of reclamation: mechanical, thermal and combined mechanical-thermal, applying for this aim adequate experimental devices. The obtained reclaims were assessed with regard to the degree of the matrix liberation from the determined binding material. Reclaims of moulding sands with binders of the form of resin were assessed with regard to ignition loss values and pH reaction, while reclaims of moulding sands with bentonite with regard to the residual clay content and pH value. In all cases the results of the performed sieve analyses were estimated and the average characteristic diameter dl was determined. The reclaimed matrix was applied as a full substitute of the fresh high-silica sand in typical procedures of preparing core sands used for making shaped samples for bending strength investigations, Rgu.

  17. SHAPE AND CONSTRUCTION OF BRICK VAULTS. CRITERIA, METHODS AND TOOLS FOR A POSSIBLE CATALOGUE

    Directory of Open Access Journals (Sweden)

    R. Brumana

    2017-05-01

    Full Text Available The use of cloister vaults in the construction of noble buildings, as covering elements for square or rectangular rooms, is widespread and well-known. The geometric continuity at the intrados makes generally possible the execution all over the span of frescoes, stucco and decorations. The construction of brick vaults, from the late Middle Age, was sped up by limiting the centering to the wooden planks arches that were instrumental in the profile determination. Nowadays, the availability of several procedures, phases and tools for carrying out a survey allows to draw reliable assumptions about the construction methods and the execution time. It is mandatory to determine the properties of the binders, the shape and dimensions of the bricks, and to carry out a comparison between the geometry of the intrados surface and the evidences emerging at the extrados. The support of the laser scanner technique allows to accurately identify the surface profile and thickness. All these indications, in turn, are useful, in view of an interpretation of the structural behavior, to identify weaknesses, and to highlight contributing factors of instability (if any. The paper focuses on a well-documented case, the Magio Grasselli palace in Cremona in which the cloister vaults of two main rooms show different construction systems, although they were built almost at the same time. The thermographic recordings and laser-scanner surveys highlight the various arrangements used for the cloister vaults.

  18. MMB-GUI: a fast morphing method demonstrates a possible ribosomal tRNA translocation trajectory.

    Science.gov (United States)

    Tek, Alex; Korostelev, Andrei A; Flores, Samuel Coulbourn

    2016-01-08

    Easy-to-use macromolecular viewers, such as UCSF Chimera, are a standard tool in structural biology. They allow rendering and performing geometric operations on large complexes, such as viruses and ribosomes. Dynamical simulation codes enable modeling of conformational changes, but may require considerable time and many CPUs. There is an unmet demand from structural and molecular biologists for software in the middle ground, which would allow visualization combined with quick and interactive modeling of conformational changes, even of large complexes. This motivates MMB-GUI. MMB uses an internal-coordinate, multiscale approach, yielding as much as a 2000-fold speedup over conventional simulation methods. We use Chimera as an interactive graphical interface to control MMB. We show how this can be used for morphing of macromolecules that can be heterogeneous in biopolymer type, sequence, and chain count, accurately recapitulating structural intermediates. We use MMB-GUI to create a possible trajectory of EF-G mediated gate-passing translocation in the ribosome, with all-atom structures. This shows that the GUI makes modeling of large macromolecules accessible to a wide audience. The morph highlights similarities in tRNA conformational changes as tRNA translocates from A to P and from P to E sites and suggests that tRNA flexibility is critical for translocation completion. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  19. Offer for our members

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    The Staff Association CERN staff has recently concluded a framework agreement with AXA Insurance Ltd, General-Guisan-Strasse 40, 8401 Winterthur. This contract allows you to benefit from a preferential tariff and conditions for insurances: Motor vehicles for passenger cars and motorcycles of the product line STRADA: 10% discount Household insurance (personal liability and household contents) the product line BOX: 10% discount Travel insurance: 10% discount Buildings: 10% discount Legal protection: 10% discount AXA is number one on the Swiss insurance market. The product range encompasses all non-life insurance such as insurance of persons, property, civil liability, vehicles, credit and travel as well as innovative and comprehensive solutions in the field of occupational benefits insurance for individuals and businesses. Finally, the affiliate AXA-ARAG (legal expenses insurance) completes the offer. For those of you already insured with the company, contact your current advisor. Others may contact a counsel...

  20. Offers for our members

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    La banque LCL propose aux membres de l’Association du personnel les avantages suivants : – Un barème Privilège sur le Prêt immobilier – Des avantages tarifaires sur l’épargne, notamment l’assurance-vie. – Un taux préférentiel de prêt à la consommation. En outre, jusqu’au 30 septembre 2013, elle offre 50€ à tous les nouveaux clients, membres de l'Association du personnel. Summer is here, enjoy our offers for the aquatic parcs! Tickets "Zone terrestre" : 21 € instead of de 26 €. Access to Aqualibi : 5 euros instead of 8 euros on presentation of your SA member ticket. Free for children (3-11 years old) before 12 h 00. Free for children under 3, with limited access to the attractions. Free car park. * * * * * * * Full day ticket: – Children : 30 CHF instead of 39 CHF &...

  1. Offers for our members

    CERN Multimedia

    Staff Association

    2013-01-01

    The warm weather arrives, it's time to take advantage of our offers Walibi and Aquapark! Walibi : Tickets "Zone terrestre": 21 € instead of 26 € Access to Aqualibi: 5 € instead of 8 € on presentation of your SA member ticket. Free for children (3-11 years old) before 12 h 00. Free for children under 3, with limited access to the attractions. Car park free. * * * * * Aquaparc : Half-day ticket (5 hours): – Children: 26 CHF instead of 35 CHF – Adults : 32 CHF instead of 43 CHF Day ticket: – Children: 30 CHF instead of 39 CHF – Adults : 36 CHF instead of 49 CHF Free for children under 5.

  2. Postgraduates courses offered to nursing

    Directory of Open Access Journals (Sweden)

    Pedro Jorge Araujo

    2011-07-01

    Full Text Available Aim: To know the official masters that the Spanish Universities have offered during the academic course 2010/2011.Material and methods: Descriptive observational and transversal court study, in which it has analysed 170 university official masters and in which it has used a questionnaire with a total of 15 questions elaborated for this work.Results: 52 Spanish Universities of the 75 that there is have offered during the academic course 2010/2011 official masters that can realise for graduated in infirmary. By areas, the official masters more offered have been the ones of nutrition and alimentary security. 76,33% of the official masters have a length of 1 academic year. Almost the half of the official masters have an orientation researcher-professional and almost 40% researcher. 62,65% of the masters give of face-to-face way. In 52,1% of the official masters do not realise external practices and 86,2% has continuity with the doctorate.Conclusions: It has seen that it is necessary that expand the number of masters including other fields of study that contribute to a main specialisation of the professionals of the infirmary. An important percentage of official masters give in face-to-face modality, and there is very few offered on-line or to distance.

  3. Single Case Method in Psychology: How to Improve as a Possible Methodology in Quantitative Research.

    Science.gov (United States)

    Krause-Kjær, Elisa; Nedergaard, Jensine I

    2015-09-01

    Awareness of including Single-Case Method (SCM), as a possible methodology in quantitative research in the field of psychology, has been argued as useful, e.g., by Hurtado-Parrado and López-López (IPBS: Integrative Psychological & Behavioral Science, 49:2, 2015). Their article introduces a historical and conceptual analysis of SCMs and proposes changing the, often prevailing, tendency of neglecting SCM as an alternative to Null Hypothesis Significance Testing (NHST). This article contributes by putting a new light on SCM as an equally important methodology in psychology. The intention of the present article is to elaborate this point of view further by discussing one of the most fundamental requirements as well as main characteristics of SCM regarding temporality. In this respect that; "…performance is assessed continuously over time and under different conditions…" Hurtado-Parrado and López-López (IPBS: Integrative Psychological & Behavioral Science, 49:2, 2015). Defining principles when it comes to particular units of analysis, both synchronic (spatial) and diachronic (temporal) elements should be incorporated. In this article misunderstandings of the SCM will be adduced, and further the temporality will be described in order to propose how the SCM could have a more severe usability in psychological research. It is further discussed how to implement SCM in psychological methodology. It is suggested that one solution might be to reconsider the notion of time in psychological research to cover more than a variable of control and in this respect also include the notion of time as an irreversible unity within life.

  4. Service Offering at Electrical Equipment Manufacturers

    Directory of Open Access Journals (Sweden)

    Lucie Kaňovská

    2015-09-01

    Full Text Available Purpose of the article: The aim of the paper is to uncover ways of managing service offering provided by electrical equipment manufactures in the Czech Republic. The segment is extremely important for Czech industry nowadays, especially because of many companies being subcontractors for the car industry and mechanical engineering. The producers of electric equipment comply with the Czech industry classification CZ-NACE 27. Methodology/methods: The questionnaire in the form of the Likert scale was prepared to gather information about customer services. The respondents were usually directors or managers, e.g. employees with high competencies of knowing customer services in this particular market. The total of 22 companies were included in the survey. Research was focused on the following industries classifications belonging to CZ-NACE 27: CZ-NACE 27, CZ-NACE 271 and CZ-NACE 273. According to Czech Statistical Office the total number of companies belonging to these 3 segments is 136. It means 16,2% companies belonging to CZ-NACE 27 participated in our research. Basic statistical methods were used to analyse the complete database. Scientific aim: The paper deals with the problem of service offering provided by today’s manufacturers. Global understanding of services that manufacturers really develop, sell, deliver and manage is still limited. Findings: Managing service offering provided by today‘s manufacturers shows that 1 Manufacturers not offer only tangible products, but also wide range of services and even information and support. 2 New products are not designed only according to company technicians, but also according to their customers. Their products and services are developed, tested and improved according to their needs. 3 Services provide complex customer care from time product selection to its end. Conclusions: Manufacturers of tangible products need to enlarge their product offering to be able to satisfy customers. Therefore

  5. Reading for empowerment: Intertextuality offers creative possibilities for enlightened citizenry

    Directory of Open Access Journals (Sweden)

    Fetson Kalua

    2012-08-01

    Full Text Available Julia Kristeva coined the term ‘intertextuality’ to explain her utter belief in the mutability and movement of texts, in contradistinction to the time-honoured popular idea that a text is an autonomous and self-evident object. For Kristeva, any text implies the existence and embedding of other texts, also known as sub-texts, within it. This has far-reaching implications for the way we read, engage with, and interpret various texts. This article describes the concept of intertextuality as a model of reading which puts the reader at the centre of the reading process. It goes on to link intertextuality to other domains of literacy, notably the notion of ‘spheres of literacy’. Central to intertextuality and spheres of literacy is their privileging of the reader, as opposed to the author, in the reading process. Finally, the article explores the ways in which our awareness and use of intertextuality can help to develop a literate and free-thinking citizenry who derive utmost autonomy and empowerment from various cultural texts accessible to them.

  6. A comparison of possibilities of using methods of internal corporate education - coaching and mentoring

    OpenAIRE

    Kolmistrová, Aneta

    2013-01-01

    This thesis examines the application of two educational methods - coaching and mentoring - in an internal corporate education system. Attention is first drawn to the concept of corporate education, while terms such as education effectiveness and procedures of actual implementation are clarified. Thereafter, both examined methods are defined and goals to achieve through these methods are presented. Both methods are then compared, with the emphasis on their similarities and differences. The the...

  7. Quantity-quality measuring method possibilities in improving operator's learning quality

    International Nuclear Information System (INIS)

    Zvonarev, V.P.

    1984-01-01

    Possibilities of obtainnjng qualitative-quantitative estimations of different aspects of learning process and their application in determination of learning purposes, substantiation of the training program choice of types and forms of studies directed at quality improvement of operator learning are considered

  8. Dynamics of vortex domain walls in ferromagnetic nanowires - A possible method for chirality manipulation

    Science.gov (United States)

    Li, Y.; Lu, Z.; Chen, C.; Cheng, M.; Yin, H.; Wang, W.; Li, C.; Liu, Y.; Xiong, R.; Shi, J.

    2018-06-01

    The dynamic behaviors of vortex domain walls (VDWs) in ferromagnetic nanowires driven by a magnetic field above Walker breakdown field (Hw) were investigated using micromagnetic simulation. It was found when nanowire has proper geometrical dimensions, the VDW may oscillate in a chirality invariant mode or a chirality switching mode depending on applied field and damping constant. At fixed damping constant, the oscillation mode can be controlled by applied field - with the increase of applied field, the oscillation of VDW change from a chirality invariant mode to a variant one. As the oscillation of VDW changes from chirality invariant regime to chirality switching regime, the oscillation frequency and amplification will undergo an abnormal change, which may offer a fingerprint for the switch of oscillation mode. Our finding proposes a simple way to control the chirality of a VDW by properly manipulating nanowire geometry and applied field, which may have important applications in VDW-based devices.

  9. Estimation of daily reference evapotranspiration (ETo) using artificial intelligence methods: Offering a new approach for lagged ETo data-based modeling

    Science.gov (United States)

    Mehdizadeh, Saeid

    2018-04-01

    Evapotranspiration (ET) is considered as a key factor in hydrological and climatological studies, agricultural water management, irrigation scheduling, etc. It can be directly measured using lysimeters. Moreover, other methods such as empirical equations and artificial intelligence methods can be used to model ET. In the recent years, artificial intelligence methods have been widely utilized to estimate reference evapotranspiration (ETo). In the present study, local and external performances of multivariate adaptive regression splines (MARS) and gene expression programming (GEP) were assessed for estimating daily ETo. For this aim, daily weather data of six stations with different climates in Iran, namely Urmia and Tabriz (semi-arid), Isfahan and Shiraz (arid), Yazd and Zahedan (hyper-arid) were employed during 2000-2014. Two types of input patterns consisting of weather data-based and lagged ETo data-based scenarios were considered to develop the models. Four statistical indicators including root mean square error (RMSE), mean absolute error (MAE), coefficient of determination (R2), and mean absolute percentage error (MAPE) were used to check the accuracy of models. The local performance of models revealed that the MARS and GEP approaches have the capability to estimate daily ETo using the meteorological parameters and the lagged ETo data as inputs. Nevertheless, the MARS had the best performance in the weather data-based scenarios. On the other hand, considerable differences were not observed in the models' accuracy for the lagged ETo data-based scenarios. In the innovation of this study, novel hybrid models were proposed in the lagged ETo data-based scenarios through combination of MARS and GEP models with autoregressive conditional heteroscedasticity (ARCH) time series model. It was concluded that the proposed novel models named MARS-ARCH and GEP-ARCH improved the performance of ETo modeling compared to the single MARS and GEP. In addition, the external

  10. AlOx Coating of Ultrastable Zeolite Y: A Possible Method for Vanadium Passivation of FCC Catalysts

    NARCIS (Netherlands)

    Weckhuysen, B.M.; Catana, Gabriela; Grünert, W.; Voort, P. van der; Vansant, E.F.; Schoonheydt, R.A.

    2000-01-01

    AlOx coating is proposed as a possible method for vanadium passivation of the ultrastable zeolite Y (USY). Two coating methods are discussed: (i) the deposition of the [Al13O4(OH)24(H2O)12]7+ ([Al13]) complex from aqueous solutions and (ii) the anchoring of alumoxane by in situ triisobutylaluminum

  11. Scintillation method possibilities for uranium detection in the lungs of a man

    International Nuclear Information System (INIS)

    Dolgirev, E.I.; Kajdanovskij, G.N.; Lossner, V.

    1978-01-01

    Detecting systems using various types of scintillation crystals were studied to find out whether it was possible to estimate the content of natural uranium in the lungs during lifetime. Data on the graduation of these systems obtained by use of an anthropomorphic phantom of the human trunk are given, as are values of minimal detectable levels of uranium in the lungs. A technique for a planned periodic monitoring of uranium in the lungs of every radiation worker is presented

  12. Environmental and economic assessment methods for waste management decision-support: possibilities and limitations.

    Science.gov (United States)

    Finnveden, Göran; Björklund, Anna; Moberg, Asa; Ekvall, Tomas

    2007-06-01

    A large number of methods and approaches that can be used for supporting waste management decisions at different levels in society have been developed. In this paper an overview of methods is provided and preliminary guidelines for the choice of methods are presented. The methods introduced include: Environmental Impact Assessment, Strategic Environmental Assessment, Life Cycle Assessment, Cost-Benefit Analysis, Cost-effectiveness Analysis, Life-cycle Costing, Risk Assessment, Material Flow Accounting, Substance Flow Analysis, Energy Analysis, Exergy Analysis, Entropy Analysis, Environmental Management Systems, and Environmental Auditing. The characteristics used are the types of impacts included, the objects under study and whether the method is procedural or analytical. The different methods can be described as systems analysis methods. Waste management systems thinking is receiving increasing attention. This is, for example, evidenced by the suggested thematic strategy on waste by the European Commission where life-cycle analysis and life-cycle thinking get prominent positions. Indeed, life-cycle analyses have been shown to provide policy-relevant and consistent results. However, it is also clear that the studies will always be open to criticism since they are simplifications of reality and include uncertainties. This is something all systems analysis methods have in common. Assumptions can be challenged and it may be difficult to generalize from case studies to policies. This suggests that if decisions are going to be made, they are likely to be made on a less than perfect basis.

  13. Possibility of determination of the level of antioxidants in human body using spectroscopic methods

    International Nuclear Information System (INIS)

    Timofeeva, E; Gorbunova, E

    2016-01-01

    In this work, the processes of antioxidant defence against aggressive free radicals in human body were investigated theoretically; and the existing methods of diagnosis of oxidative stress and disturbance of antioxidant activity were reviewed. Also, the kinetics of free radical reactions in the oxidation of luminol and interaction antioxidants (such as chlorophyll in the multicomponent system of plant's leaves and ubiquinone) with the UV radiation were investigated experimentally by spectroscopic method. The results showed that this method is effective for recording the luminescence of antioxidants, free radicals, chemiluminescent reactions and fluorescence. In addition these results reveal new opportunities for the study of the antioxidant activity and antioxidant balance in a multicomponent system by allocating features of the individual components in spectral composition. A creation of quality control method for drugs, that are required for oxidative stress diagnosis, is a promising direction in the development of given work. (paper)

  14. Possibilities of the application of multicriteria analysis and PROMETHEE methods, on an example of aircraft choice

    Directory of Open Access Journals (Sweden)

    Aleksandar Ž. Drenovac

    2012-07-01

    Full Text Available This paper proves that the application of the PROMETHEE method, one of better known methods of multicriteria optimization, can be used as a generalized criterion for many different situations when solving diverse problems and at all levels of the military organization. The decision-making process can be simplified, resulting in a higher level of reliability of decisions of the Ministry of Defence and higher levels of command in Serbian Armed Forces while solving important multicriteria problems above all.

  15. Teaching Research Methods and Statistics in eLearning Environments: Pedagogy, Practical Examples, and Possible Futures

    OpenAIRE

    Rock, Adam J.; Coventry, William L.; Morgan, Methuen I.; Loi, Natasha M.

    2016-01-01

    Generally, academic psychologists are mindful of the fact that, for many students, the study of research methods and statistics is anxiety provoking (Gal, Ginsburg, & Schau, 1997). Given the ubiquitous and distributed nature of eLearning systems (Nof, Ceroni, Jeong, & Moghaddam, 2015), teachers of research methods and statistics need to cultivate an understanding of how to effectively use eLearning tools to inspire psychology students to learn. Consequently, the aim of the present paper is to...

  16. User evaluations offer promise for pod-intravaginal ring as a drug delivery platform: A mixed methods study of acceptability and use experiences.

    Science.gov (United States)

    Guthrie, Kate M; Rosen, Rochelle K; Vargas, Sara E; Getz, Melissa L; Dawson, Lauren; Guillen, Melissa; Ramirez, Jaime J; Baum, Marc M; Vincent, Kathleen L

    2018-01-01

    Effective HIV prevention requires efficient delivery of safe and efficacious drugs and optimization of user adherence. The user's experiences with the drug, delivery system, and use parameters are critical to product acceptability and adherence. Prevention product developers have the opportunity to directly control a drug delivery system and its impact on acceptability and adherence, as well as product efficacy. Involvement of potential users during preclinical design and development can facilitate this process. We embedded a mixed methods user evaluation study into a safety and pharmacokinetics (PK) trial of a pod-intravaginal ring delivering antiretroviral agents. Women enrolled in two cohorts, ultimately evaluating the safety/PK of a pod-IVRs delivering TDF-alone, TDF-FTC, and/or TDF-FTC-MVC. A 7-day use period was targeted for each pod-IVR, regardless of drug or drug combination. During the clinical study, participants provided both quantitative (i.e., survey) and qualitative (i.e., in-depth interview) data capturing acceptability, perceptibility, and adherence behaviors. Initial sexual and reproductive health history surveys, daily diaries, a final acceptability and willingness to use survey, and a qualitative in-depth interview comprised the user evaluation data for each pod-IVR experienced by the participants. Overall, the majority of participants (N = 10) reported being willing to use the pod-IVR platform for HIV prevention should it advance to market. Confidence to use the pod-IVR (e.g., insertion, removal) was high. There were no differences noted in the user experience of the pod-IVR platform; that is, whether the ring delivered TDF-alone, TDF-FTC, or TDF-FTC-MVC, users' experiences of the ring were similar and acceptable. Participants did report specific experiences, both sensory and behavioral, that impacted their use behaviors with respect to the ring, and which could ultimately impact acceptability and adherence. These experiences, and user

  17. Using possibility of QFD method for development of the "ready-to-go" package

    Directory of Open Access Journals (Sweden)

    Jelena Dragoljub Krstic

    2014-07-01

    Full Text Available Although quality function deployment (QFD is the mostly used in the development of new products, the methodology is equally varied and applied as a packaging design/development tool. Due to the fact that the demands of the market, i.e. users are constantly changing, the designers of all products, as well as the designers of packaging for food products, must implement the introduced requirements on the newly design of its products. The goal of this paper was to explain the QFD method with the aim to understand the mode of its operation and implementation, with an explanation of its potential for practical application in the packaging design process, as well as to highlight all the advantages and disadvantages of this method. The goal of the implementation of QFD method during the development of the packaging, as one of the types of products, is to find exactly the features and functions of the customer, i.e. what the user expects from the packaging, i.e. by this method, customer's voice transforms into new products that really meet their needs. It can be concluded that the application of QFD methods can reduce the length of the product development cycle, in this case the packaging, while simultaneously improving the quality and marketing of products in the market.

  18. [Quality management in surgery--an overview of methods and possibilities].

    Science.gov (United States)

    Schmidt, C; Möller, J; Reibe, F; Güntert, B; Kremer, B

    2003-06-01

    Numerous methods of assessing quality in health care have been presented over the last years. Since the German health care reform of 2000 introduced a legal obligation to quality assurance, hospitals have to meet that condition. However, no specific system of quality assurance was implicated. Therefore, many potential users search for systems suiting their own needs. However, German hospitals can benefit from international experience in quality management. Accreditation, visitation, excellence schemes, and certification seem to be the dominant methods. Every method is worthy of hospital evaluation. Certifications illustrate the quality system view without regard to profession, while excellence schemes evaluate the development of quality management in hospitals. Accreditation portrays a specific hospital as a whole, while visitations follow the professional perspective of quality assurance. Depending on the perspective and aims, there are advantages and disadvantages in each method. Finally, a combination of two may also be helpful. Indeed, no "role model" exists yet for assessing quality in health care. These methods of quality management are applicable especially in surgery, because a variety of standard outcome parameters such as length of stay, duration of procedure, and complication and relapse rates are already available.

  19. 48 CFR 570.303-3 - Late offers, modifications of offers, and withdrawals of offers.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Late offers, modifications of offers, and withdrawals of offers. 570.303-3 Section 570.303-3 Federal Acquisition Regulations... PROPERTY Contracting Procedures for Leasehold Interests in Real Property 570.303-3 Late offers...

  20. CURRENT METHODS OF ENDOTHELIAL DYSFUNCTION ASSESSMENT AND THEIR POSSIBLE USE IN THE PRACTICAL MEDICINE

    Directory of Open Access Journals (Sweden)

    A. V. Shabrov

    2016-01-01

    Full Text Available A review contains a description of the most common methods of evaluation and monitoring of "endothelial dysfunction" that are assessed in terms of their information content and applicability in the practice of medicine. The term "endothelial function" is interpreted primarily as a function of the regulation of capillary blood flow, carried out by the expense of the dynamic change of the phase of vasoconstriction and vasodilatation in vessels of resistive type (in accordance with the changing needs of cellular metabolism. Assessment of endothelial dysfunction is understood as a generalized indicator of the extent and nature of violations of the regulation of peripheral circulation. It includes an assessment of imbalances between endotheliumdependent vasoconstrictor and vasodilating factors or mismatch of the local and central regulation of capillary blood flow in response to various functional tests or other effects (eg, cold test, or test with local ischemia. All methods of endothelial dysfunction assessment in the survey are divided into invasive and non-invasive. The main feature of invasive methods lies in the direct effect on the endothelium of the coronary or other vessels by introducing into these vessels vasoactive substances such as acetylcholine. Response to the test (vasoconstriction or vasodilation is evaluated by coronary angiography or by ultrasound. Non-invasive methods of the assessment of endothelial dysfunction or functions of regulation of the peripheral circulation are regarded as the most promising for widespread use. There are two basic methods that underlie functional tests: methods PAT (peripheral arterial tone and PHG (polyhepatography. Assessment of endothelial dysfunction in many modern scientific researches is important. They are regarded as the causative factors of many different diseases. Such assessments can be useful in everyday medical practice. Assessment of endothelial function provides the clinician with

  1. Possibilities of Utilizing the Method of Analytical Hierarchy Process Within the Strategy of Corporate Social Business

    Science.gov (United States)

    Drieniková, Katarína; Hrdinová, Gabriela; Naňo, Tomáš; Sakál, Peter

    2010-01-01

    The paper deals with the analysis of the theory of corporate social responsibility, risk management and the exact method of analytic hierarchic process that is used in the decision-making processes. The Chapters 2 and 3 focus on presentation of the experience with the application of the method in formulating the stakeholders' strategic goals within the Corporate Social Responsibility (CSR) and simultaneously its utilization in minimizing the environmental risks. The major benefit of this paper is the application of Analytical Hierarchy Process (AHP).

  2. A computational method for comparing the behavior and possible failure of prosthetic implants

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, C.; Hollerbach, K.; Perfect, S.; Underhill, K.

    1995-05-01

    Prosthetic joint implants currently in use exhibit high Realistic computer modeling of prosthetic implants provides an opportunity for orthopedic biomechanics researchers and physicians to understand possible in vivo failure modes, without having to resort to lengthy and costly clinical trials. The research presented here is part of a larger effort to develop realistic models of implanted joint prostheses. The example used here is the thumb carpo-metacarpal (cmc) joint. The work, however, can be applied to any other human joints for which prosthetic implants have been designed. Preliminary results of prosthetic joint loading, without surrounding human tissue (i.e., simulating conditions under which the prosthetic joint has not yet been implanted into the human joint), are presented, based on a three-dimensional, nonlinear finite element analysis of three different joint implant designs.

  3. A survey of direct inversion methods having possible application to tunnel detection

    International Nuclear Information System (INIS)

    Mager, R.D.

    1985-01-01

    Within recent years there has been considerable interest in the development of geophysical methods for the location of hidden underground tunnels and cavities. Consideration of this problem has been motivated by military applications, such as the detection of shallow man-made tunnels and arm caches, as well as civilian applications such as detection of limestone cavities in karst terrain and the mapping of abandoned mine workings. There are also applications for in-situ coal gasification and for the monitoring of nuclear waste disposal sites. The most reliable method presently used to map these underground anomalies has been direct detection by closely spaced drilling. However, the high cost of drilling renders this method impractical except for detailed and localized mapping, and certainly unfeasible for any type of broad-scale reconnaissance activity. Largely motivated by petroleum and mineral exploration needs, however, the seismic industry has seen a virtual revolution in acquisition and processing techniques within the past ten years. Paralleling these developments have been corresponding developments in acoustical imaging and non-destructive testing. Researchers in the field of inverse scattering have produced a number of new methods for target imaging from backscattered reflection data

  4. Radium accumulation in animal thyroid glands: a possible method for uranium and thorium prospecting

    International Nuclear Information System (INIS)

    Wogman, N.A.; Brodzinski, R.L.; Middlesworth, L.V.

    1976-01-01

    A method of prospecting for uranium and thorium is proposed based on uptake of their radioactive daughters, 226 Ra and 228 Ra, by plants, the collection of plant material by herbivores, the concentration of the radioactive species by specific animal tissues, and the subsequent gamma-ray analysis of the tissues

  5. Childhood and Adolescent Animal Cruelty Methods and Their Possible Link to Adult Violent Crimes

    Science.gov (United States)

    Hensley, Christopher; Tallichet, Suzanne E.

    2009-01-01

    Few researchers have investigated the potentially predictive power of childhood and adolescent animal cruelty methods as they are associated with subsequent interpersonal violence in adulthood. Based on a sample of 261 inmates at medium- and maximum-security prisons in a southern state, the present study examines the relationship between several…

  6. Soil sampling and extraction methods with possible application to pear thrips (Thysanoptera: Thripidae)

    Science.gov (United States)

    John E. Bater

    1991-01-01

    Techniques are described for the sampling and extraction of microarthropods from soil and the potential of these methods to extract the larval stages of the pear thrips, Taeniothrips inconsequens (Uzel), from soil cores taken in sugar maple stands. Also described is a design for an emergence trap that could be used to estimate adult thrips...

  7. Offer

    CERN Multimedia

    Staff Association

    2015-01-01

    Le parc ouvre ses portes le samedi 4 avril 2015!   La Chasse aux Oeufs du 4 au 26 avril En plus de ses 25 attractions et spectacles, le parc proposera aux enfants de 3 à 12 ans de relever le challenge d’une course aux oeufs dans un jardin de Pâques reconstitué ! Autant de petits oeufs à trouver dans un temps limite ; tout cela au milieu de lapins, poules, fleurs et autres oeufs géants pour repartir avec des gourmandises en chocolat de la marque Revillon Chocolatier.   Profitez de notre offre spéciale pour nos membres : Tarif unique Adulte/Enfant Entrée Zone terrestre 21,50 euros au lieu de 27 euros Accès à l’Aqualibi : 5 euros au lieu de 8 euros sur présentation du billet d’entrée au tarif membre AP. Entrée gratuite pour les enfants de moins de 3 ans, avec accès limité aux attractions. Les billet...

  8. Offers

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    Staff Association

    2014-01-01

      Bénéficiez du tarif spécial de 35 CHF/personne + 1 accompagnant au Théâtre de Carouge  en étant membre de l’Association du personnel.  Envoyez votre réservation par mail à smills@tcag.ch via votre adresse mail professionnelle. Indiquez la date de votre réservation, votre nom, prénom et numéro de téléphone. Une confirmation de réservation vous sera retournée par mail. La présentation de votre carte de membre sera demandée lors du retrait des billets.   De Molière – Mise en scène de Jean Liermier Argan, veuf, remarié avec Béline qui n’attend que la mort de son mari pour hériter, multiplie saignées, purges et autres ingestions de remèdes. Angélique, sa fille, vuet &a...

  9. OFFERS

    CERN Multimedia

    Staff Association

    2014-01-01

    Nouveau partenaire - Joy’s Club   Venez profiter des remises au Joy’s Club / Minigolf à Divonne-les-bains en tant que membre de l’Association ! Sur présentation de votre carte membre, vous bénéficierez d’une remise immédiate telle que : - Pour une partie adulte : 6 euros au lieu de 7 euros - Pour une partie enfant : 4 euros au lieu de 5 euros - Pour le mini Park : 6 euros au lieu de 7 euros Pour plus de renseignements, n’hésitez pas à demander au Secrétariat de l’Association ou à consulter notre site web: http://staff-association.web.cern.ch/fr/socioculturel/offres  

  10. Offers

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    2014-01-01

    12 % discount on football camps and courses for children from 3 to 13 years old, with bilingual coaches.   Now also courses during the autumn holidays! In order to get the discount you need to register online, then send a mail to info@intersoccer.ch with a scan of your membership card to recieve a refund of the discount.

  11. Offers

    CERN Multimedia

    Staff association

    2014-01-01

        Envie de soirée au théâtre, n’hésitez pas à bénéficier de nos offres pour nos membres ! Théâtre de Carouge : Réduction de 5 CHF pour tous les spectacles (30 CHF au lieu de 35 CHF) Le théâtre de Carouge vous présente sa nouvelle pièce : La double insconstance Du vedredi 21 mars au dimanche 6 avril 2014 De Marivaux Mise en scène de Philippe Mentha Audio-description le mardi 1er avril et le samedi 5 avril 2014 Il règne un doux mélange de révoltes et de séductions, de ruses et de fatalité dans cette Double Inconstance de Marivaux que met en scène Philippe Mentha, membre fondateur du Théâtre de Carouge et directeur depuis plus de trente ans du Théâtre Kléber-Méleau. L’allure d...

  12. Offers

    CERN Multimedia

    Staff Association

    2015-01-01

    Tickets "Zone terrestre": 21 € instead of 27 €. Access to Aqualibi: 5 € instead of 8 € on presentation of your SA member ticket. Free for children (3-11 years old) before 12 h 00. Free for children under 3, with limited access to the attractions. Car park free.

  13. Offers

    CERN Multimedia

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    2013-01-01

    Découvrez les plus belles tables de Suisse romande et de France voisine en bénéficiant des réductions suivantes sur chaque repas, pendant une année : 50 % pour 2 personnes, 40 % pour 3 personnes, 30 % pour 4 personnes, 20 % pour 5 à 6 personnes. Comment ça marche ? Faites votre choix parmi les 110 restaurants de votre région et réservez votre table pour 2, 3, 4, 5 ou 6 personnes. Présentez votre Passeport Gourmand dès votre arrivée. Savourez votre repas et profitez d’une réduction exceptionnelle sur votre addition (hors boissons, menu du jour et business lunch). Quels sont vos avantages ? Profitez du prix préférentiel pour les membres de l’association du CERN : – Passeport Gourmand Genève : CHF 75.- (au lieu de CHF 95.-) – Passeport Gourmand Ain/Savoie/Haute-Savoie : CHF 59.- (au lieu de CH...

  14. Offers

    CERN Multimedia

    Staff Association

    2012-01-01

    Si cette offre vous intéresse, merci d’envoyer un mail à mh.boulanger@comedie.ch avec le détail de votre réservation via votre adresse mail professionnelle. Le retrait des places se fait à la billetterie sur présentation de votre carte de membre de l’Association du personnel. Pour toute commande d’abonnement ou de carte de réduction par courrier ou internet, cocher le tarif collectif en indiquant le nom de l’entreprise et en joignant un justificatif nominatif. Pour tout renseignement, n’hésitez pas à contacter Marie-Hélène Boulanger : –  Tel. : 022 809 60 86 –  email : mh.boulanger@comedie.ch

  15. Offers

    CERN Multimedia

    Staff Association

    2013-01-01

    Découvrez les plus belles tables de Suisse romande et de France voisine en bénéficiant des réductions suivantes sur chaque repas, pendant une année : 50 % pour 2 personnes / 40 % pour 3 personnes / 30 % pour 4 personnes / 20 % pour 5 à 6 personnes. Comment ça marche ? Faites votre choix parmi les 110 restaurants de votre région et réservez votre table pour 2, 3, 4, 5 ou 6 personnes. Présentez votre Passeport Gourmand dès votre arrivée. Savourez votre repas et profitez d’une réduction exceptionnelle sur votre addition (hors boissons, menu du jour et business lunch). Quels sont vos avantages ? Profitez du prix préférentiel pour les membres de l’association du CERN : – Passeport Gourmand Genève : CHF 75.- (au lieu de CHF 95.-) – Passeport Gourmand Ain/Savoie/Haute-Savoie : CHF 59.- (au lieu de...

  16. Offers

    CERN Multimedia

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    2013-01-01

    Concert Scoop music tour sur le parc Walibi ! Vendredi 12 Juillet Vous trouverez la présentation de l’événement et les vidéos des artistes attendus avec leurs titres faisant vibrer les radios en ce moment sur le site internet http://www.walibi.com/rhone-alpes/fr-fr/evenements/scoop-music-tour. Le concert est gratuit et débute à la fermeture du parc avec une première partie surprise. Profitez donc d’une belle journée sur le parc et finissez en beauté avec le concert de l’été !

  17. Offers

    CERN Multimedia

    Staff Association

    2014-01-01

    To our members 5% discount on Fnac vouchers Vouchers of 50.-, 100.- et 200. - CHF Valid in the 4 shops in Switzerland without restriction on purchases. On sale in the office of Secretariat of the staff Association.

  18. On the possibility of reprocessing spent nuclear fuel and radioactive waste by plasma methods

    Energy Technology Data Exchange (ETDEWEB)

    Vorona, N. A.; Gavrikov, A. V., E-mail: gavrikov@ihed.ras.ru; Samokhin, A. A.; Smirnov, V. P. [Russian Academy of Sciences, Joint Institute for High Temperatures (Russian Federation); Khomyakov, Yu. S. [Innovation–Technology Center of the Project Proryv (Russian Federation)

    2015-12-15

    The concept of plasma separation of spent nuclear fuel and radioactive waste is presented. An approach that is based on using an accelerating potential to overcome the energy and angular spread of plasma ions at the separation region inlet and utilizing a potential well to separate spatially the ions of different masses is proposed. It is demonstrated that such separation may be performed at distances of about 1 m with electrical potentials of about 1 kV and a magnetic field of about 1 kG. The estimates of energy consumption and performance of the plasma separation method are presented. These estimates illustrate its potential for technological application. The results of development and construction of an experimental setup for testing the method of plasma separation are presented.

  19. Biological dosimetry of local radiation accidents of skin: possible cytological and biochemical methods

    International Nuclear Information System (INIS)

    Potten, C.S.

    1986-01-01

    Skin erythema or skin reaction is a highly dose-dependent change in skin appearance. A few gray can usually be detected in humans but higher doses are usually required for experimental rodents. The disadvantages are that the end-point is subjective and the response strongly influenced by numerous physical and biological factors. Changes in the levels of pigmentation can be detected in the epidermis and possibly the hair follicles but generally these only become apparent after chronic exposures. The skin appendages, particularly the hair follicles, could represent sensitive systems for detecting radiation exposures, but the cyclic behaviour of the hair follicles is difficult to control or determine in an accident. Acute cell death can be measured in the follicle germ and changes in the thickness and appearance of the hair are easily detected: in severe cases there is loss of hair (epilation). The number of dead cells per follicle section increased at a rate of 2.9/Gy and doses of about 0.2Gy can be easily detected. The width of the hair is reduced by about 7-8%/Gy and this change, which results in a dysplastic hair is believed to be the consequences of cell death in the follicles. (author)

  20. The Possibility of Using of Selected Biotechnological Method by Dwarf Rabbit

    Directory of Open Access Journals (Sweden)

    Martin Fik

    2013-10-01

    Full Text Available The aim of this work was to evaluate the possibility of using insemination in small scale breed condition of lop dwarf white of red eyes. Monitored were three groups of does. In group 1 was used to induce receptivity an agent-based PMSG. In Group 2 to induce receptivity was used 30 minute common housing (8 - 10 of does before insemination. In group 3 was used natural mating. State of receptivity was recorded through a numerical scale 1 (pale vulva, 2 (pink vulva, 3 (red vulva and 4 (violet vulva. Does in group 1 and 2 were inseminated polysperm insemination dose (0.3 ml / doe. By comparing the receptivity in group 1 (state of receptivity 2.81 and 2 (state of receptivity 2.56 were not found statistically significant differences. The best reproduction results were recorded in group 1 where on the one done insemination accounted for 3.12 pc of newborn pups. The number of pups born per one done insemination was 2.04 pc. The lowest scores were recorded in group 3 where the number of pups born per one successfully copulated doe was 1.3 pc.

  1. Possible evolutions of rare isotope production methods and the associated instrumentation

    International Nuclear Information System (INIS)

    Mittig, W.

    2013-01-01

    Highlights: • High intensity light and heavy ion accelerators reach up to MW average beam power. • Large solid angle spectrometers achieved high resolution by sophisticated corrections. • Optimization depends on the global layout of the accelerator-experimental devices. • Optimization of the use of primary and secondary beams is new frontier opening now. -- Abstract: In recent decades, an impressive progress was made in high intensity light and heavy ion accelerators, reaching now several hundreds kilowatts to megawatt average beam power. Simultaneously, large solid angle spectrometers were developed, preserving good resolution properties by the introduction of sophisticated high order corrections. For further progress in the study of the properties of nuclei far from stability, it will be important to optimize the global layout of the accelerator-experimental devices. It will be more and more important to take radiation safety concerns into account since the very conception of the devices. The global efficiency to obtain a result concerning the properties of a given nucleus depends not only on the detection efficiencies but also on the resolution of the measurement device. Another new frontier may open now, this is the optimization of the use of primary and secondary beams to avoid dumping of possibly useful beams, and utilize them for multiple purposes. Different aspects of this optimization will be discussed

  2. Is it possible to diagnose idiopathic chondropathia of the patella by radiological methods

    International Nuclear Information System (INIS)

    Kaufmann, J.; Langlotz, M.; Zurich Univ.

    1984-01-01

    In a retrospective study of 47 cases of chondromalacia proved by operation, a correct diagnosis had been made by arthrography in three cases. In 44 patients a false negative finding had been obtained. A prospective study was carried out comparing single and double contrast arthrography as well as double contrast arthrotomography and scintigraphy in ten patients with typical chondropathia. It was confirmed by arthroscopy in nine cases. Only two patients with severe chondromalacia showed abnormal findings by arthrography or scintigraphy. Our investigation has led to the conclusion that arthrography is not a suitable method for demonstrating idiopathic chondropathia of the patella. (orig.) [de

  3. Age of Saurashtra miliolites by U-Th decay series methods: possible implications to their origin

    International Nuclear Information System (INIS)

    Hussain, N.; Bhandari, N.; Ramanathan, K.R.; Somayajulu, B.L.K.

    1980-01-01

    The miliolite deposits of Saurashtra have been dated by 234 U, 230 Th, 231 Pa and 14 C methods. Concordant ages of approximately 10 5 years using the U decay series isotopes are obtained which agree with the ages of the coral reefs of Okha-Dwaraka coast suggesting a contemporaneous origin for both. The lower 14 C ages (<= 40,000 years) may be due to a recent influx of seawater or ground water. Quartz and clay minerals together constitute only <= 10% by weight, as such the aeolin characteristics of quartz grains may not be relevant to the origin of the miliolites. (auth.)

  4. A possible method to produce a polarized antiproton beam at intermediate energies

    International Nuclear Information System (INIS)

    Spinka, H.; Vaandering, E.W.; Hofmann, J.S.

    1994-01-01

    A feasible and conservative design for a medium energy polarized antiproton beam has been presented. The design requires an intense beam of unpolarized antiprotons (≥ 10 7 /sec) from a typical secondary beam line in order to achieve reasonable anti pp elastic scattering count rates. All three beam spin directions can be achieved. Methods were discussed to reverse the spin directions in modest times, and to change to a polarized proton beam if desired. It is expected that experiments with such a beam would have a profound effect on the understanding of the anti NN interaction at intermediate energies

  5. Is it possible to diagnose idiopathic chondropathia of the patella by radiological methods

    Energy Technology Data Exchange (ETDEWEB)

    Kaufmann, J.; Langlotz, M.

    1984-10-01

    In a retrospective study of 47 cases of chondromalacia proved by operation, a correct diagnosis had been made by arthrography in three cases. In 44 patients a false negative finding had been obtained. A prospective study was carried out comparing single and double contrast arthrography as well as double contrast arthrotomography and scintigraphy in ten patients with typical chondropathia. It was confirmed by arthroscopy in nine cases. Only two patients with severe chondromalacia showed abnormal findings by arthrography or scintigraphy. Our investigation has led to the conclusion that arthrography is not a suitable method for demonstrating idiopathic chondropathia of the patella.

  6. Age of Saurashtra miliolites by U-Th decay series methods: possible implications to their origin

    Energy Technology Data Exchange (ETDEWEB)

    Hussain, N; Bhandari, N; Ramanathan, K R; Somayajulu, B L.K. [Physical Research Lab., Ahmedabad (India)

    1980-03-01

    The miliolite deposits of Saurashtra have been dated by /sup 234/U, /sup 230/Th, /sup 231/Pa and /sup 14/C methods. Concordant ages of approximately 10/sup 5/ years using the U decay series isotopes are obtained which agree with the ages of the coral reefs of Okha-Dwaraka coast suggesting a contemporaneous origin for both. The lower /sup 14/C ages (<= 40,000 years) may be due to a recent influx of seawater or ground water. Quartz and clay minerals together constitute only <= 10% by weight, as such the aeolin characteristics of quartz grains may not be relevant to the origin of the miliolites.

  7. [When to consult the institutional bioethics committee? The deliberative method for resolving possible dilemmas].

    Science.gov (United States)

    Rabadán, Alejandra T; Tripodoro, Vilma A

    2017-01-01

    In healthcare, an ethical concern that arises during the decision making process is considered to be a bioethical dilemma. It is often the case that in the absence of proper deliberation, the problem is transferred to a bioethics committee, not even representing precisely a dilemma. Bioethics emerged as a discipline in the mid-20th century. It is defined as a support to decision-making in ethical dilemmas centered on two aspects: ethics of clinical investigation, focused on protecting the rights of research subjects, and bioethics in medical practice, of an advisory nature. To recognize the difference among difficult or complex clinical circumstances and ethical dilemmas could allow knowing when it is necessary to request for advice of a committee. It is not so much a question of deciding what is right or wrong, but which is the most advisable solution to a problem. We review the history of Bioethics Committees in Argentina that are facing today the challenge of promoting social responsibility and opening deliberations to community and health professionals. In the 20th century two historical moments are recognized: a pioneering and slow first period, and a second one of legal regulatory framework. Considering deliberation as a method of ethics, this article proposes a case analysis procedure and the deliberative method to elucidate dilemmas, with or without the help of a Committee.

  8. Carbonated hydrocalumite synthesized by the microwave method as a possible antacid

    Energy Technology Data Exchange (ETDEWEB)

    Linares, Carlos F., E-mail: clinares@uc.edu.ve [Unidad de Síntesis de Materiales y Metales de Transición, Facultad de Ciencias y Tecnología, Departamento de Química, Universidad de Carabobo, Valencia, Edo, Carabobo Apartado Postal 3336 (Venezuela, Bolivarian Republic of); Moscosso, Joel; Alzurutt, Victor; Ocanto, Freddy; Bretto, Pablo [Unidad de Síntesis de Materiales y Metales de Transición, Facultad de Ciencias y Tecnología, Departamento de Química, Universidad de Carabobo, Valencia, Edo, Carabobo Apartado Postal 3336 (Venezuela, Bolivarian Republic of); González, Gema [Laboratorio de Materiales, Centro Tecnológico, Instituto Venezolano de Investigaciones Científicas (IVIC), Carretera Panamericana Km 11 Altos de Pipe, Los Teques (Venezuela, Bolivarian Republic of)

    2016-04-01

    A carbonated hydrocalumite was synthesized by the microwave method for being used as antacid. The gel was formed using Ca and Al nitrate solutions in a basic medium (NaOH + Na{sub 2}CO{sub 3}), then, this gel was aged and heated in a domestic microwave for 2.5 min (1250 W). The obtained white solid was washed with distilled water, dried in an oven at 100 °C for 18 h and characterized by different techniques such as: X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FT-IR), BET surface area measurements, scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX). Finally, the carbonated hydrocalumite was tested as antacid by using a synthetic gastric juice and its activity was compared with a commercial antacid formulated with hydrotalcite. Results showed that the carbonated hydrocalumite was more effective than that commercial antacid. - Highlights: • Carbonated hydrocalumite was synthesized by the microwave method. • The aging time was drastically reduced. • Carbonated hydrocalumite was more active as antacid than a commercial antacid based on hydrotalcites.

  9. When to consult the institutional bioethics committee? The deliberative method for resolving possible dilemmas

    Directory of Open Access Journals (Sweden)

    Alejandra T Rabadán

    2017-12-01

    Full Text Available In healthcare, an ethical concern that arises during the decision making process is considered to be a bioethical dilemma. It is often the case that in the absence of proper deliberation, the problem is transferred to a bioethics committee, not even representing precisely a dilemma. Bioethics emerged as a discipline in the mid-20th century. It is defined as a support to decision-making in ethical dilemmas centered on two aspects: ethics of clinical investigation, focused on protecting the rights of research subjects, and bioethics in medical practice, of an advisory nature. To recognize the difference among difficult or complex clinical circumstances and ethical dilemmas could allow knowing when it is necessary to request for advice of a committee. It is not so much a question of deciding what is right or wrong, but which is the most advisable solution to a problem. We review the history of Bioethics Committees in Argentina that are facing today the challenge of promoting social responsibility and opening deliberations to community and health professionals. In the 20th century two historical moments are recognized: a pioneering and slow first period, and a second one of legal regulatory framework. Considering deliberation as a method of ethics, this article proposes a case analysis procedure and the deliberative method to elucidate dilemmas, with or without the help of a Committee.

  10. Possibilities of the particle finite element method for fluid-soil-structure interaction problems

    Science.gov (United States)

    Oñate, Eugenio; Celigueta, Miguel Angel; Idelsohn, Sergio R.; Salazar, Fernando; Suárez, Benjamín

    2011-09-01

    We present some developments in the particle finite element method (PFEM) for analysis of complex coupled problems in mechanics involving fluid-soil-structure interaction (FSSI). The PFEM uses an updated Lagrangian description to model the motion of nodes (particles) in both the fluid and the solid domains (the later including soil/rock and structures). A mesh connects the particles (nodes) defining the discretized domain where the governing equations for each of the constituent materials are solved as in the standard FEM. The stabilization for dealing with an incompressibility continuum is introduced via the finite calculus method. An incremental iterative scheme for the solution of the non linear transient coupled FSSI problem is described. The procedure to model frictional contact conditions and material erosion at fluid-solid and solid-solid interfaces is described. We present several examples of application of the PFEM to solve FSSI problems such as the motion of rocks by water streams, the erosion of a river bed adjacent to a bridge foundation, the stability of breakwaters and constructions sea waves and the study of landslides.

  11. Integrated application of health improving methods of Pilates and Bodyflex for improving psychophysiological possibilities of students

    Directory of Open Access Journals (Sweden)

    Zh.L. Kozina

    2014-03-01

    Full Text Available Purpose: to determine the effect of complex application procedures Bodyflex and Pilates using information and communication technology on the level of psycho-physiological capabilities of students. Material: the study involved 46 university students. Research methods - physiological (speed detection of simple and complex reactions in different modes of testing, the level of functional mobility and strength of the nervous system, pedagogical experiment, methods of mathematical statistics. Results: the positive effect on the level of the developed technique psychophysiological capacities of students. The application of the developed technique in the experimental group showed a significant decrease in the latency time of a simple visual-motor reaction time latent complex visual-motor reaction time test run "level of functional mobility of nervous processes" in feedback mode. Found that the use of Bodyflex and Pilates promotes strength of nervous processes. Conclusions: the recommended use in the learning process of students of complex techniques of Pilates Bodyflex using information and communication technologies, increased levels of psychophysiological features, mobility and strength of the nervous processes.

  12. Some possibilities of the slow electron diffraction method when studying film systems

    International Nuclear Information System (INIS)

    Kirsanova, T.S.; Tumareva, T.A.; Kiseleva, L.A.

    1982-01-01

    A film structure of an initial thickness was studied with film probing in depth by an electron beam; for this purpose energy of incident electrons changed in sufficient wide ranges. Barium oxide films of 6-10 monolayer thickness deposited on a monocrystal (110) W have been chosen for the investigation. The structure was detected in a certain temperature range (850-1250 K) and the maximum development, the largest energy range fit approximatly 1000-1100 K temperature. Optimal temperature increases slightly with increasing an initial film thickness. The investigations carried on have shown that the structure of barium oxide films is heterogeneous in the layer thickness. This is concerned espicially the films of 6-10 monolayers. Notwithstanding the thickness trifle, the ''surface'' which structure was different from a region immediately adjacent to a substrate may be separated in films of this area. The method of the investigation in layers, i. e. the method for observing the film structure when varying incident electron energy permitted to establish that an absolute by certain structure of the layer adjacent to a substrate corresponds to each structure of the surface layer. In turn the structures of the layer adjacent to a substrate for the total film thickness of 6-10 monolayers turn out to be similar to the structures of 2-5 monolayer film, anyhow these structures are described with similar diffraction pictures

  13. Carbonated hydrocalumite synthesized by the microwave method as a possible antacid.

    Science.gov (United States)

    Linares, Carlos F; Moscosso, Joel; Alzurutt, Victor; Ocanto, Freddy; Bretto, Pablo; González, Gema

    2016-04-01

    A carbonated hydrocalumite was synthesized by the microwave method for being used as antacid. The gel was formed using Ca and Al nitrate solutions in a basic medium (NaOH+Na2CO3), then, this gel was aged and heated in a domestic microwave for 2.5 min (1250 W). The obtained white solid was washed with distilled water, dried in an oven at 100 °C for 18 h and characterized by different techniques such as: X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FT-IR), BET surface area measurements, scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX). Finally, the carbonated hydrocalumite was tested as antacid by using a synthetic gastric juice and its activity was compared with a commercial antacid formulated with hydrotalcite. Results showed that the carbonated hydrocalumite was more effective than that commercial antacid. Copyright © 2016 Elsevier B.V. All rights reserved.

  14. Modern methods of drilling wells by large diameter bits and possible fields of application

    Energy Technology Data Exchange (ETDEWEB)

    Arnold, W

    1970-04-01

    For the needs of up-to-date mining in construction of shafts and mining installations, large diameter wells are often used. In the near future, application of this type of well will be of great importance in the oil industry for stimulation of oil and gas recovery by atomic explosion. Such wells can be used for mineral extraction from subsea and other accessible deposits. The presented state of drilling techniques and technology by large diameter bits is described and similarities and differences with deep-well drilling are pointed out. Some economical data indicate the advantage of drilling by large-diameter bits in comparison with standard methods of construction of shafts and mining installations.

  15. Possibilities Of Metals Extracton From Spent Metallic Automotive Catalytic Converters By Using Biometallurgical Method

    Directory of Open Access Journals (Sweden)

    Willner J.

    2015-09-01

    Full Text Available The main task of automotive catalytic converters is reducing the amount of harmful components of exhaust gases. Metallic catalytic converters are an alternative to standard ceramic catalytic converters. Metallic carriers are usually made from FeCrAl steel, which is covered by a layer of Precious Group Metals (PGMs acting as a catalyst. There are many methods used for recovery of platinum from ceramic carriers in the world, but the issue of platinum and other metals recovery from metallic carriers is poorly described. The article presents results of preliminary experiments of metals biooxidation (Fe, Cr and Al from spent catalytic converters with metallic carrier, using bacteria of the Acidithiobacillus genus.

  16. Radiation purification of the chemical industry effluents and possibilities of realization of this method

    International Nuclear Information System (INIS)

    Petryaev, E.P.; Kovalevskaya, A.M.; Shlyk, V.G.; Savushkin, I.A.; Kazazyan, V.T.

    1977-01-01

    Radiation-chemical methods for synthetic fibre industry effluents purification from cyanides, sulphides and monomers, as well as for disinfection of circulation water and improvement in sedimental and filtering properties of waste active slurry in petrochemical industry are described. Chemical plant effluents are purified by 70-90% from cyanides at the dose rate of 0,3 - 0,5 Mrad, by 60 - 70% from sulphides and monomers at the dose of 0,2 Mrad. Circulation water of petroleum processing plant is disinfected at the dose of 0,08 Mrad; the rates of filtration and sedimentation of waste active slurry increase two and three fold, correspondingly, at the dose of 0,6 Mrad. The power of radiation sources required for the industrial realization of radiation purification of liquid wastes has been calculated

  17. Cumulative Mass and NIOSH Variable Lifting Index Method for Risk Assessment: Possible Relations.

    Science.gov (United States)

    Stucchi, Giulia; Battevi, Natale; Pandolfi, Monica; Galinotti, Luca; Iodice, Simona; Favero, Chiara

    2018-02-01

    Objective The aim of this study was to explore whether the Variable Lifting Index (VLI) can be corrected for cumulative mass and thus test its efficacy in predicting the risk of low-back pain (LBP). Background A validation study of the VLI method was published in this journal reporting promising results. Although several studies highlighted a positive correlation between cumulative load and LBP, cumulative mass has never been considered in any of the studies investigating the relationship between manual material handling and LBP. Method Both VLI and cumulative mass were calculated for 2,374 exposed subjects using a systematic approach. Due to high variability of cumulative mass values, a stratification within VLI categories was employed. Dummy variables (1-4) were assigned to each class and used as a multiplier factor for the VLI, resulting in a new index (VLI_CMM). Data on LBP were collected by occupational physicians at the study sites. Logistic regression was used to estimate the risk of acute LBP within levels of risk exposure when compared with a control group formed by 1,028 unexposed subjects. Results Data showed greatly variable values of cumulative mass across all VLI classes. The potential effect of cumulative mass on damage emerged as not significant ( p value = .6526). Conclusion When comparing VLI_CMM with raw VLI, the former failed to prove itself as a better predictor of LBP risk. Application To recognize cumulative mass as a modifier, especially for lumbar degenerative spine diseases, authors of future studies should investigate potential association between the VLI and other damage variables.

  18. Possible reaction pathways of the lincomycin molecule according to the DFT calculation method

    Directory of Open Access Journals (Sweden)

    Eren Bahar

    2017-01-01

    Full Text Available Human-used antibiotics are eliminated from the body with little or no transformation at all. Traces of eliminated antibiotics enter the receiving environment directly since they cannot be treated in prevalent wastewater treatment facilities. Thus, wastewaters containing traces of antibiotics have to be treated accordingly. Lincomycin is subsequently isolated from Streptomyces lincolnensis. Lincomycin and its derivatives are antibiotics exhibiting biological activity against Gram-positive bacteria, and are natural antibiotics in the environment as pollutants. This study aims to predict the degradation mechanism of lincomycin molecule in the gaseous phase and aqueous media. Probable reaction path of lincomycin molecule with OH radicals was analyzed. Optimized geometry was calculated via Gauss View 5. Subsequently, the lowest energy status was determined through geometric optimization via Gaussian 09 program. Aiming to determine the intermediates in photocatalytic degradation mechanism of lincomycin, geometric optimization of the molecule was realized through DFT method. Activation energy for the probable reaction path was calculated, and their most stable state from the thermodynamic perspective determined for the gaseous phase and aqueous media. Impact of water solvent was investigated using the conductor-like screening solvation model (COSMO. The predicted mechanism was confirmed by comparison with experimental results on simple structures reported in literature.

  19. Endoscopic Vasectomy of Male Feral Pigeons (Columba livia) as a Possible Method of Population Control.

    Science.gov (United States)

    Heiderich, Elisabeth; Schildger, Bernd; Lierz, Michael

    2015-03-01

    To evaluate whether single-entry endoscopic vasectomy of male feral pigeons (Columba livia) significantly reduced fertility and would potentially be valuable for control of feral pigeon populations, 252 male feral pigeons were caught in the city of Berne and endoscopically vasectomized. In this procedure, approximately 1 cm of the deferent duct was removed bilaterally. Rapid, uneventful recoveries occurred in 94% (237/252) of the pigeons, whereas 6% (15/252) died because of complications associated with the procedure, consisting of perforation of the ureter (9/15), major hemorrhage (5/15), and respiratory arrest (1/15). Mean anesthesia time was 23±6 minutes. The vasectomized males were habituated to 2 pigeon houses together with fertile females. Another pigeon house with fertile pairs acted as control. All eggs laid were candled weekly to assess fertility. In the 2 pigeon houses with vasectomized males, the mean fertilization rate was 0.9% (5/563), while in the control pigeon house, the rate was 100% (39/39). The results indicate that endoscopic vasectomy of male feral pigeons may be a promising tool for field control of feral pigeon populations, especially in combination with other methods such as pigeon houses.

  20. An evaluation of possible EU air transport emissions trading scheme allocation methods

    International Nuclear Information System (INIS)

    Morrell, Peter

    2007-01-01

    The European Commission has been requested by member states to study the incorporation of air transport into their existing emissions trading scheme (ETS). Only CO 2 is to be included, at least initially. This paper focuses on the method of allocation of emissions permits in the EU context. It has been assumed here that the EU ETS will be applied only to intra-EU flights and that airlines will be the entities selected for implementation. Three UK airlines were selected to evaluate three main types of allocation: grandfathering, auctioning and benchmarking. The airlines were representative of the three major airline business models: network, low-cost carrier and charter/leisure. Based on 2003/2004 aircraft/engine type and operating data, the per passenger impact of each allocation option was analysed for each airline. A new benchmarking approach is proposed that takes into account both the landing and take-off (LTO) cycle and per kilometre emissions: this avoids penalising shorter sector operators and focuses on the damage caused by aircraft and their engines and not on passengers. (author)

  1. A simple method to estimate restoration volume as a possible predictor for tooth fracture.

    Science.gov (United States)

    Sturdevant, J R; Bader, J D; Shugars, D A; Steet, T C

    2003-08-01

    Many dentists cite the fracture risk posed by a large existing restoration as a primary reason for their decision to place a full-coverage restoration. However, there is poor agreement among dentists as to when restoration placement is necessary because of the inability to make objective measurements of restoration size. The purpose of this study was to compare a new method to estimate restoration volumes in posterior teeth with analytically determined volumes. True restoration volume proportion (RVP) was determined for 96 melamine typodont teeth: 24 each of maxillary second premolar, mandibular second premolar, maxillary first molar, and mandibular first molar. Each group of 24 was subdivided into 3 groups to receive an O, MO, or MOD amalgam preparation design. Each preparation design was further subdivided into 4 groups of increasingly larger size. The density of amalgam used was calculated according to ANSI/ADA Specification 1. The teeth were weighed before and after restoration with amalgam. Restoration weight was calculated, and the density of amalgam was used to calculate restoration volume. A liquid pycnometer was used to calculate coronal volume after sectioning the anatomic crown from the root horizontally at the cementoenamel junction. True RVP was calculated by dividing restoration volume by coronal volume. An occlusal photograph and a bitewing radiograph were made of each restored tooth to provide 2 perpendicular views. Each image was digitized, and software was used to measure the percentage of the anatomic crown restored with amalgam. Estimated RVP was calculated by multiplying the percentage of the anatomic crown restored from the 2 views together. Pearson correlation coefficients were used to compare estimated RVP with true RVP. The Pearson correlation coefficient of true RVP with estimated RVP was 0.97 overall (Pvolume of restorative material in coronal tooth structure. The fact that it can be done in a nondestructive manner makes it attractive for

  2. Offering Incentives from the Outside

    DEFF Research Database (Denmark)

    Emmanuel, Nikolas G.

    2017-01-01

    Incentives offer a good deal of underexplored opportunities to help manage conflict by encouraging political bargaining. This study has two primary objectives. First, it furthers the discussion of how external third parties can help manage conflicts. Second, it offers a typology of the available ...

  3. Finding possible transition states of defects in silicon-carbide and alpha-iron using the dimer method

    CERN Document Server

    Gao Fei; Weber, W J; Corrales, L R; Jonsson, H

    2003-01-01

    Energetic primary recoil atoms from ion implantation or fast neutron irradiation produce isolated point defects and clusters of both vacancies and interstitials. The migration energies and mechanisms for these defects are crucial to successful multiscale modeling of microstructural evolution during ion-implantation, thermal annealing, or under irradiation over long periods of time. The dimer method is employed to search for possible transition states of interstitials and small interstitial clusters in SiC and alpha-Fe. The method uses only the first derivatives of the potential energy to find saddle points without knowledge of the final state of the transition. In SiC, the possible migration pathway for the C interstitial is found to consist of the first neighbor jump via a Si site or second neighbor jump, but the relative probability for the second neighbor jump is very low. In alpha-Fe, the possible transition states are studied as a function of interstitial cluster size, and the lowest energy barriers corr...

  4. Possibilities of the Integration of the Method of the Ecologically Oriented Independent Scientific Research in the Study Process

    Science.gov (United States)

    Grizans, Jurijs; Vanags, Janis

    2010-01-01

    The aim of this paper is to analyse possibilities of the integration of the method of the ecologically oriented independent scientific research in the study process. In order to achieve the set aim, the following scientific research methods were used: analysis of the conceptual guidelines for the development of environmentally oriented entrepreneurship, interpretation of the experts' evaluation of the ecologically oriented management, analysis of the results of the students' ecologically oriented independent scientific research, as well as monographic and logically constructive methods. The results of the study give an opportunity to make conclusions and to develop conceptual recommendations on how to introduce future economics and business professionals with the theoretical and practical aspects of ecologically oriented management during the study process.

  5. Body size distribution in ground beetles (Coleoptera: Carabidae) as a possible monitoring method of environmental impacts of transgenic maize

    DEFF Research Database (Denmark)

    Grumo, Davide di; Lövei, Gabor L.

    2015-01-01

    Despite the obligatory post-market environmental monitoring of genetically modified (GM) crops in Europe, there are no available standards on methods. Our aim was to examine the suitability of using changes in carabid body size distribution as a possible monitoring method. The sampling was carried...... informative Lorenz asymmetry coefficients. A total of 6339 carabids belonging to 38 species were captured and indentified. The analysis detected a shift in size distribution between months but no important differences in the assemblages in Bt vs. non-Bt maize plots were found. We concluded that an increasing...... body size trend from spring to autumn was evident, and the use of a multilevel analysis was important to correctly interpret the body size distribution. Therefore, the proposed methods are indeed sensitive to subtle changes in the structure of the carabid assemblages, and they have the potential...

  6. The estimation possibility of cleaning from radionuclides for the coast parts of drainage system by the soil fractionating method

    International Nuclear Information System (INIS)

    Karlin, Y.V.; Chuikov, V.Y.; Belianina, N.G.; Barinov, A.S.

    1996-01-01

    In this paper is considered the possibility of the cleaning from the radionuclides for the coast parts of the drainage system at the Moscow SIA open-quotes Radonclose quotes by the soil fractionating treatment. It is showed that this method cannot to be used for the cleaning of the soils near water flowing (a river, a spring or a open drainage system) because the most part of the soil size-fractions is the fine fractions and the main contaminant radionuclide ( 137 Cs) is distributed among the different soil components homogeneously

  7. new possibilities in diagnostic radiology

    OpenAIRE

    Scheel, Michael

    2014-01-01

    Diffusion Tensor Imaging (DTI) allows a non-invasive diffusion-based tissue characterization and thus offers completely new possibilities in the field of diagnostic radiology. On the one hand, this method allows an improved detection of pathological changes at the microstructural level, which are frequently not detectable in conventional MRI methods. On the other hand new strategies for therapy monitoring are feasible by quantification of diffusion parameters (e.g., Parallel, Radial and Mean ...

  8. Teaching Research Methods and Statistics in eLearning Environments:Pedagogy, Practical Examples and Possible Futures

    Directory of Open Access Journals (Sweden)

    Adam John Rock

    2016-03-01

    Full Text Available Generally, academic psychologists are mindful of the fact that, for many students, the study of research methods and statistics is anxiety provoking (Gal, Ginsburg, & Schau, 1997. Given the ubiquitous and distributed nature of eLearning systems (Nof, Ceroni, Jeong, & Moghaddam, 2015, teachers of research methods and statistics need to cultivate an understanding of how to effectively use eLearning tools to inspire psychology students to learn. Consequently, the aim of the present paper is to discuss critically how using eLearning systems might engage psychology students in research methods and statistics. First, we critically appraise definitions of eLearning. Second, we examine numerous important pedagogical principles associated with effectively teaching research methods and statistics using eLearning systems. Subsequently, we provide practical examples of our own eLearning-based class activities designed to engage psychology students to learn statistical concepts such as Factor Analysis and Discriminant Function Analysis. Finally, we discuss general trends in eLearning and possible futures that are pertinent to teachers of research methods and statistics in psychology.

  9. An Offer You Cannot Refuse: Obtaining Efficiency and Fairness in Preplay Negotiation Games with Conditional Offers

    DEFF Research Database (Denmark)

    Goranko, Valentin; Turrini, Paolo

    2013-01-01

    . Such offers transform the payoff matrix of the original game and allow for some degree of cooperation between rational players while preserving the non-cooperative nature of the game. We focus on 2-player negotiations games arising in the preplay phase when offers for payments are made conditional...... on a suggested matching offer of the same kind being made in return by the receiver. We study and analyze such bargaining games, obtain results describing their possible solutions and discuss the degrees of efficiency and fairness that can be achieved in such negotiation process depending on whether time...

  10. New offer for our members

    CERN Document Server

    Staff Association

    2018-01-01

    Evolution 2, your specialist for Outdoor Adventures Be it for a ski lesson, a parachute jump or for a mountain bike descent, come live an unforgettable experience with our outdoor specialists. Benefit from a 10 % discount on all activities: Offer is open to SA members and their family members living in the same household, upon presentation of the membership card. Offer available for all bookings made between 1 June 2018 and 30 May 2019. Offer available on all the Evoltion2 sites. A wide range of summer and winter activities. More information on http://evolution2.com/ Contact and reservation : +33 (0)4.50.02.63.35 management@evolution2.com

  11. Line-averaging measurement methods to estimate the gap in the CO2 balance closure – possibilities, challenges, and uncertainties

    Directory of Open Access Journals (Sweden)

    A. Ziemann

    2017-11-01

    Full Text Available An imbalance of surface energy fluxes using the eddy covariance (EC method is observed in global measurement networks although all necessary corrections and conversions are applied to the raw data. Mainly during nighttime, advection can occur, resulting in a closing gap that consequently should also affect the CO2 balances. There is the crucial need for representative concentration and wind data to measure advective fluxes. Ground-based remote sensing techniques are an ideal tool as they provide the spatially representative CO2 concentration together with wind components within the same voxel structure. For this purpose, the presented SQuAd (Spatially resolved Quantification of the Advection influence on the balance closure of greenhouse gases approach applies an integrated method combination of acoustic and optical remote sensing. The innovative combination of acoustic travel-time tomography (A-TOM and open-path Fourier-transform infrared spectroscopy (OP-FTIR will enable an upscaling and enhancement of EC measurements. OP-FTIR instrumentation offers the significant advantage of real-time simultaneous measurements of line-averaged concentrations for CO2 and other greenhouse gases (GHGs. A-TOM is a scalable method to remotely resolve 3-D wind and temperature fields. The paper will give an overview about the proposed SQuAd approach and first results of experimental tests at the FLUXNET site Grillenburg in Germany. Preliminary results of the comprehensive experiments reveal a mean nighttime horizontal advection of CO2 of about 10 µmol m−2 s−1 estimated by the spatially integrating and representative SQuAd method. Additionally, uncertainties in determining CO2 concentrations using passive OP-FTIR and wind speed applying A-TOM are systematically quantified. The maximum uncertainty for CO2 concentration was estimated due to environmental parameters, instrumental characteristics, and retrieval procedure with a total amount of approximately

  12. Line-averaging measurement methods to estimate the gap in the CO2 balance closure - possibilities, challenges, and uncertainties

    Science.gov (United States)

    Ziemann, Astrid; Starke, Manuela; Schütze, Claudia

    2017-11-01

    An imbalance of surface energy fluxes using the eddy covariance (EC) method is observed in global measurement networks although all necessary corrections and conversions are applied to the raw data. Mainly during nighttime, advection can occur, resulting in a closing gap that consequently should also affect the CO2 balances. There is the crucial need for representative concentration and wind data to measure advective fluxes. Ground-based remote sensing techniques are an ideal tool as they provide the spatially representative CO2 concentration together with wind components within the same voxel structure. For this purpose, the presented SQuAd (Spatially resolved Quantification of the Advection influence on the balance closure of greenhouse gases) approach applies an integrated method combination of acoustic and optical remote sensing. The innovative combination of acoustic travel-time tomography (A-TOM) and open-path Fourier-transform infrared spectroscopy (OP-FTIR) will enable an upscaling and enhancement of EC measurements. OP-FTIR instrumentation offers the significant advantage of real-time simultaneous measurements of line-averaged concentrations for CO2 and other greenhouse gases (GHGs). A-TOM is a scalable method to remotely resolve 3-D wind and temperature fields. The paper will give an overview about the proposed SQuAd approach and first results of experimental tests at the FLUXNET site Grillenburg in Germany. Preliminary results of the comprehensive experiments reveal a mean nighttime horizontal advection of CO2 of about 10 µmol m-2 s-1 estimated by the spatially integrating and representative SQuAd method. Additionally, uncertainties in determining CO2 concentrations using passive OP-FTIR and wind speed applying A-TOM are systematically quantified. The maximum uncertainty for CO2 concentration was estimated due to environmental parameters, instrumental characteristics, and retrieval procedure with a total amount of approximately 30 % for a single

  13. Methodical Challenges and a Possible Resolution in the Assessment of Receptor Reserve for Adenosine, an Agonist with Short Half-Life

    Directory of Open Access Journals (Sweden)

    Judit Zsuga

    2017-05-01

    Full Text Available The term receptor reserve, first introduced and used in the traditional receptor theory, is an integrative measure of response-inducing ability of the interaction between an agonist and a receptor system (consisting of a receptor and its downstream signaling. The underlying phenomenon, i.e., stimulation of a submaximal fraction of receptors can apparently elicit the maximal effect (in certain cases, provides an opportunity to assess the receptor reserve. However, determining receptor reserve is challenging for agonists with short half-lives, such as adenosine. Although adenosine metabolism can be inhibited several ways (in order to prevent the rapid elimination of adenosine administered to construct concentration–effect (E/c curves for the determination, the consequent accumulation of endogenous adenosine biases the results. To address this problem, we previously proposed a method, by means of which this bias can be mathematically corrected (utilizing a traditional receptor theory-independent approach. In the present investigation, we have offered in silico validation of this method by simulating E/c curves with the use of the operational model of agonism and then by evaluating them using our method. We have found that our method is suitable to reliably assess the receptor reserve for adenosine in our recently published experimental setting, suggesting that it may be capable for a qualitative determination of receptor reserve for rapidly eliminating agonists in general. In addition, we have disclosed a possible interference between FSCPX (8-cyclopentyl-N3-[3-(4-(fluorosulfonylbenzoyloxypropyl]-N1-propylxanthine, an irreversible A1 adenosine receptor antagonist, and NBTI (S-(2-hydroxy-5-nitrobenzyl-6-thioinosine, a nucleoside transport inhibitor, i.e., FSCPX may blunt the effect of NBTI.

  14. Petroleum development offers way out of poverty

    International Nuclear Information System (INIS)

    Mollet, P.

    1996-01-01

    The North African states of Algeria, Libya, Tunisia and Egypt are starting to explore the possibility of fuelling their economic development using their petroleum reserves which have not, as yet, been exploited. Poverty and Islamic extremism is widespread, leading to political difficulties domestically and a reluctance on the part of international oil companies to reinvest in the region. Despite these problems, growth in the local petroleum industry may yet offer a path to economic growth. (UK)

  15. THE POSSIBILITY OF REDUCING THE IMPACT OF TRAFFIC NOISE ON THE PERSON IN THE PASSENGER CARS OF A RAILWAY TRANSPORT IS THE METHOD, BASED ON THE MASKING EFFECT

    Directory of Open Access Journals (Sweden)

    S. V. Shmakov

    2008-01-01

    Full Text Available The problem of reduction of the long-term traffic noise effect on the person in coach passenger spaces is examined. The method of solving the problem is offered. The corresponding calculations and analysis of results are performed. The functional diagram on technical realization of this method is proposed.

  16. The Opinion of Latvian Teachers About the Most Suitable Teaching Methods and Possibilities to Make Lessons Interesting

    Directory of Open Access Journals (Sweden)

    Porozovs Juris

    2017-12-01

    Full Text Available Student’s learning motivation and learning outcomes depend on the ability of the teacher to interest students, the chosen teaching methods and proficiency to manage the learning process. Teacher who can successfully choose teaching content, material resources and different teaching methods is able to cause interest about his subject. Teacher who is interested in teaching process himself can help students to learn a subject. The aim of the study was to find out the Latvian teachers' opinion about the disturbing factors affecting the achievement of high learning outcomes for students, the most suitable teaching methods and the possibilities to make lessons interesting. The survey of teachers of different schools in Latvia regarding their students’ learning motivation was carried out. The data from 482 teachers’ answers were analysed. The results of the research showed that the majority of surveyed teachers consider that learning motivation of Latvia students has decreased during the last few years. Teachers point out several factors, which do not allow students to reach high learning outcomes, the most important of them are: the inability of students to link career and success with learning and lack of life goals; inability of students to concentrate attention during lessons; indisposition of students to do homework. The teachers consider laboratory works, discussions, project works, group works and teacher’s presentations and narrative of new material as the most suitable teaching methods. Teachers consider that the most important personality trait of teachers and learning motivation for students to improve their skills is the teacher’s ability to teach the subject in an interesting way. Teachers believe that lessons can be made interesting if modern technologies and teaching methods are used during lessons and when the teacher is able to connect the subject with real life.

  17. Analysis of possibility to apply new mathematical methods (R-function theory) in Monte Carlo simulation of complex geometry

    International Nuclear Information System (INIS)

    Altiparmakov, D.

    1988-12-01

    This analysis is part of the report on ' Implementation of geometry module of 05R code in another Monte Carlo code', chapter 6.0: establishment of future activity related to geometry in Monte Carlo method. The introduction points out some problems in solving complex three-dimensional models which induce the need for developing more efficient geometry modules in Monte Carlo calculations. Second part include formulation of the problem and geometry module. Two fundamental questions to be solved are defined: (1) for a given point, it is necessary to determine material region or boundary where it belongs, and (2) for a given direction, all cross section points with material regions should be determined. Third part deals with possible connection with Monte Carlo calculations for computer simulation of geometry objects. R-function theory enables creation of geometry module base on the same logic (complex regions are constructed by elementary regions sets operations) as well as construction geometry codes. R-functions can efficiently replace functions of three-value logic in all significant models. They are even more appropriate for application since three-value logic is not typical for digital computers which operate in two-value logic. This shows that there is a need for work in this field. It is shown that there is a possibility to develop interactive code for computer modeling of geometry objects in parallel with development of geometry module [sr

  18. Investigation of the Practical Possibility of Solving Problems on Generalized Cellular Automata Associated with Cryptanalysis by Mean Algebraic Methods

    Directory of Open Access Journals (Sweden)

    P. G. Klyucharev

    2017-01-01

    Full Text Available A number of previous author’s papers proposed methods for constructing various cryptographic algorithms, including block ciphers and cryptographic hash functions, based on generalized cellular automata. This one is aimed at studying a possibility to use the algebraic cryptanalysis methods related to the construction of Gröbner bases for the generalized cellular automata to be applied in cryptography, i.e. this paper studies the possibility for using algebraic cryptanalysis methods to solve the problems of inversion of a generalized cellular automaton and recovering the key of such an automaton.If the cryptographic algorithm is represented as a system of polynomial equations over a certain finite field, then its breach is reduced to solving this system with respect to the key. Although the problem of solving a system of polynomial equations in a finite field is NP-difficult in the general case, the solution of a particular system can have low computational cost.Cryptanalysis based on the construction of a system of polynomial equations that links plain text, cipher-text and key, and its solution by algebraic methods, is usually called algebraic cryptanalysis. Among the main methods to solve systems of polynomial equations are those to construct Gröbner bases.Cryptanalysis of ciphers and hash functions based on generalized cellular automata can be reduced to various problems. We will consider two such problems: the problem of inversion of a generalized cellular automaton, which, in case we know the values of the cells after k iterations, enables us to find the initial values. And the task of recovering the key, which is to find the initial values of the remaining cells, using the cell values after k steps and the initial values of a part of the cells.A computational experiment was carried out to solve the two problems above stated in order to determine the maximum size of a generalized cellular automaton for which the solution of these

  19. Literature studies and tests of non-destructive testing methods with possible applications for concrete construction in nuclear power plants

    International Nuclear Information System (INIS)

    Ulriksen, Peter

    2010-09-01

    The present report details a survey of methods suitable for detecting delamination in nuclear power-plant cooling-water channels. It is also a close-up study of the russian instrument A1220 Monolith manufactured by ACSYS. The measuring principle is that echoes from discontinuities within the concrete are recorded as a function of time. By assuming a velocity this time can be converted to a depth. The instrument is known for operating with shear-waves at 55 kHz and it has generated impressive images of structures in the concrete like rebars, voids, thickness and horizontal cracks (delamination). Since the instrument simultaneously introduces three novelties, i.e. -Dry-point coupling between transducer and concrete -Shear waves -Transmitter and receiver consisting of several elements there is reason to try and understand which of the novelties is responsible for the good results and what requirements there would be on the methodology. A special interest is directed towards the possibility to use the instrument together with an automated X-Y-scanner with the purpose to obtain high resolution 3D imagery. A such survey is possible to perform with the instrument, but as soon as the number of measuring points comes above a couple of hundreds the task becomes tiresome. It is suitable to perform automated measurements with a grid of 1 cm. It was discovered that it is possible to connect S-wave as well as P-wave transducers to the instrument. Delamination can be detected with several methods. Thermography should be mentioned but will not be treated in this report. The best options are supposed to be: -Profiling with the A1220 instrument in dry channels -Profiling with a sonar in a water filled channel -Vibration measurements using a water-jet in a dry channel -Impedance measurements in a dry channel Impedance measurements are well developed regarding theory and improvements can take place in the methodology. This can hopefully be performed in a future project. The

  20. The offerings from the Hyperboreans.

    Science.gov (United States)

    Ruck, C A

    1983-08-01

    The ancient Greeks believed that the fruits of agriculture could be harvested only if one first appeased the spirit of the primitive avatars from which the edible crop had been evolved over the centuries through hybridization and cultivation. On occasion, this appeasement was secured through the sacrifice of a human victim, a person who for various reasons could be considered to represent a similar primitivism. By the classical age, this extreme form of sacrificial appeasement appears to have been reserved for times of unusual crisis, such as pestilence or natural disaster, for at such times, the resurgent forces of primitivism seemed to threaten the entire civilization with regression back to its wilder origins. Other forms of appeasement were ordinarily substituted for the actual offering of a human victim. Amongst these was the enactment of puberty rites, for the natural growth and maturation of an individual could be thought to symbolize this same evolutionary process. Each infant is born as a wild creature who must develop into a socialized adult through the metaphoric death of its former self as it assumes the responsibilities of civilized life in crossing the threshold to sexual maturity. A similar symbolic victim was customarily represented by the offering of first fruits. A portion of the cultivated crop was prematurely cut and consecrated to redeem and release the ripening harvest from the dangerous contamination with the spirits of its pre-agricultural precedents. On the island of Delos, a special version of this consecration was performed. Each year, the various Greek cities would send a sheaf of unripened grain to the sanctuary of the god Apollo and his twin sister Artemis. Amongst these annual offerings, there was one that was supposed to have originated from the Hyperboreans, a mythical people who were thought to live in the original homeland of the two gods. This special Hyperborean offering differed from the others, for it was said to contain a

  1. Advanced methods for a probabilistic safety analysis of fires. Development of advanced methods for performing as far as possible realistic plant specific fire risk analysis (fire PSA)

    International Nuclear Information System (INIS)

    Hofer, E.; Roewekamp, M.; Tuerschmann, M.

    2003-07-01

    In the frame of the research project RS 1112 'Development of Methods for a Recent Probabilistic Safety Analysis, Particularly Level 2' funded by the German Federal Ministry of Economics and Technology (BMWi), advanced methods, in particular for performing as far as possible realistic plant specific fire risk analyses (fire PSA), should be developed. The present Technical Report gives an overview on the methodologies developed in this context for assessing the fire hazard. In the context of developing advanced methodologies for fire PSA, a probabilistic dynamics analysis with a fire simulation code including an uncertainty and sensitivity study has been performed for an exemplary scenario of a cable fire induced by an electric cabinet inside the containment of a modern Konvoi type German nuclear power plant taking into consideration the effects of fire detection and fire extinguishing means. With the present study, it was possible for the first time to determine the probabilities of specified fire effects from a class of fire events by means of probabilistic dynamics supplemented by uncertainty and sensitivity analyses. The analysis applies a deterministic dynamics model, consisting of a dynamic fire simulation code and a model of countermeasures, considering effects of the stochastics (so-called aleatory uncertainties) as well as uncertainties in the state of knowledge (so-called epistemic uncertainties). By this means, probability assessments including uncertainties are provided to be used within the PSA. (orig.) [de

  2. Phase-based x-ray scattering—A possible method to detect cancer cells in a very early stage

    Energy Technology Data Exchange (ETDEWEB)

    Feye-Treimer, U., E-mail: feye-treimer@helmholtz-berlin.de; Treimer, W. [Department of Mathematics, Physics and Chemistry, University of Applied Sciences, D-13353 Berlin, Germany and Joint Department G-GTOMO, Helmholtz Zentrum fuer Materialien und Energie Berlin, D-14109 Berlin (Germany)

    2014-05-15

    diseased. Conclusions: With this proposed method it should be in principle possible to detect cancer cells in apparently healthy tissues in biopsies and/or in samples of the far border region of abscised or excised tissues. Thus this method could support established methods in diagnostics of cancer-suspicious samples.

  3. Antifungal Effect of Henna against Candida albicans Adhered to Acrylic Resin as a Possible Method for Prevention of Denture Stomatitis

    Science.gov (United States)

    Nawasrah, Amal; AlNimr, Amani; Ali, Aiman A.

    2016-01-01

    Denture stomatitis is a very common disease affecting the oral mucosa of denture wearers. The aim of this study was to measure the antifungal effect of henna against Candida albicans adhered to acrylic resin as a possible method for prevention of denture stomatitis. One-hundred-eighty acrylic plates were prepared of heat-cured acrylic denture resin. The specimens were divided into six groups of 30 samples each. The first group was only polymer and monomer following the conventional manufacturer instruction for processing complete dentures. The other five groups were processed by adding different concentration of Yamani henna powder (Harazi) to the polymer in a concentration of henna: polymer 1%, 2.5%, 5%, 7.5% and 10%, respectively. Samples were incubated in artificial saliva rich with Candida albicans at 37 °C, and the effect of henna on Candida albicans was evaluated in two different methods: semi-quantitative slide count and a culture-based quantitative assay (quantitative). Variation in the number of live Candida was observed with the increase in the concentration of Yamani henna powder. It was observed that the variation in live Candida, between control group and group B (concentration of Yamani henna powder was 1%), was statistically significant with a p-value of 0.0001. Similarly, variations in live Candida were significant, when the concentration of powder was 7.5% or 10% in contrast with control group and p-values were 0.0001 and 0.001 respectively. Adding henna to acrylic resin denture could be effective in controlling Candida albicans proliferation on the denture surface; however, its effects on the physical properties of acrylic resin denture need further studies. PMID:27223294

  4. Is it possible to predict the presence of colorectal cancer in a blood test?: a probabilistic approach method

    Directory of Open Access Journals (Sweden)

    José Manuel Navarro-Rodríguez

    Full Text Available Introduction: The assessment of the state of immunosurveillance (the ability of the organism to prevent the development of neoplasias in the blood has prognostic implications of interest in colorectal cancer. We evaluated and quantified a possible predictive character of the disease in a blood test using a mathematical interaction index of several blood parameters. The predictive capacity of the index to detect colorectal cancer was also assessed. Methods: We performed a retrospective case-control study of a comparative analysis of the distribution of blood parameters in 266 patients with colorectal cancer and 266 healthy patients during the period from 2009 to 2013. Results: Statistically significant differences (p < 0.05 were observed between patients with colorectal cancer and the control group in terms of platelet counts, fibrinogen, total leukocytes, neutrophils, systemic immunovigilance indexes (neutrophil to lymphocyte ratio and platelet to lymphocyte ratio, hemoglobin, hematocrit and eosinophil levels. These differences allowed the design of a blood analytical profile that calculates the risk of colorectal cancer. This risk profile can be quantified via a mathematical formula with a probabilistic capacity to identify patients with the highest risk of the presence of colorectal cancer (area under the ROC curve = 0.85. Conclusions: We showed that a colorectal cancer predictive character exists in blood which can be quantified by an interaction index of several blood parameters. The design and development of interaction indexes of blood parameters constitutes an interesting research line for the development and improvement of programs for the screening of colorectal cancer.

  5. CJEP will offer open science badges.

    Science.gov (United States)

    Pexman, Penny M

    2017-03-01

    This editorial announces the decision of the Canadian Journal of Experimental Psychology (CJEP) to offer Open Science Framework (OSF) Badges. The Centre for Open Science provides tools to facilitate open science practices. These include the OSF badges. The badges acknowledge papers that meet standards for openness of data, methods, or research process. They are now described in the CJEP Submission Guidelines, and are provided in the editorial. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  6. Policy offers protection from harassment

    Science.gov (United States)

    McNutt, Marcia

    We face a number of legal and ethical issues in our work as scientists and as AGU members. To uphold the highest ethical standards in our professional activities, the Council has adopted policies on free access to published material, ethics in publishing, and misconduct in science. But what about guidelines to govern the personal behavior that constitutes harassment, sexual or otherwise?For years the AGU headquarters staff has had a policy that offers protection from harassment and rules for dealing with it, but the membership went without one until 1994. That year the Council adopted a policy that extends to the membership as well as to the staff and the vendors they encounter at meetings. The law only requires a policy to prevent harassment in the workplace, but the Council felt that a harassment policy was particularly important for members because the subtle behavior that can constitute harassment is most likely to occur at events that combine work and social interaction, such as the meetings, conferences, and training seminars that AGU members attend.

  7. A study of a possible early reindeer domestication site on the Iamal peninsula (Russia) using geoarchaeological methods and lipid biomarkers.

    Science.gov (United States)

    Harrault, Loic; Milek, Karen; Dawson, Lorna; Anderson, David

    2016-04-01

    In past centuries, indigenous hunters in Northern Eurasia shifted from being hunters to being herders of reindeer. Even at low human population densities, large reindeer herds can alter the landscape and leave long-term biochemical signatures in the soil. Although indigenous social-ecological systems have been thought to be resilient in space and time, most are considered to be at risk due to climate and socio-economic changes related to anthropogenic activities. This situation calls for a long-term perspective to place human-animal relations in their respective contexts. As an ancient livelihood still practiced across vast areas of Northern Eurasia, reindeer herding is a nexus for feedbacks between humans, animals and environment. The Iarte site, on the Iuribei River in the central part of the Iamal peninsula is thought to be an important site of reindeer domestication dating back to the 12th century due to the enormous quantities of butchered reindeer bones found in recent excavations. The large amount of buried reindeer bones found at the settlement suggests that herds should have stood near the site despite the lack of any architectural remains of corrals or pens. The history of a possible early relation to domesticate reindeer can be described with geoarchaeological methods, including lipid biomarkers, which can indicate the presence of past human and animal activities. Among lipid biomarkers, faecal markers such as stanols and bile acids have already been used in archaeological contexts to identify and distinguish between different species because they are persistent over time and can have a species specific profile. Near the Iarte settlement, we conducted a soil survey and sampling programme and combined geoarchaeological measurements (including electrical conductivity, magnetic susceptibility and elemental analysis) with lipid analysis of soil samples, to identify the potential presence of standing reindeer herds. The different soil layers have been

  8. POSSIBILITIES OF APPLYING THE DEA METHOD IN THE ASSESSMENT OF EFFICIENCY OF COMPANIES IN THE ELECTRIC POWER INDUSTRY: REVIEW OF WIND ENERGY COMPANIES

    Directory of Open Access Journals (Sweden)

    Dario Maradin

    2014-07-01

    Full Text Available One of the fundamental tasks of modern power system is finding ways to produce stable and continuous electricity from scarce energy resources. One of the possible solutions is introduction, implementation and improvement of alternative forms of energy such as renewable energy sources, particularly wind energy as an increasingly important energy source which is expected to further increase its share in total electricity production. Numerous methods can be used in assessing the efficiency of wind energy companies, and in the focus of this research is the Data Envelopment Analysis method (DEA, a widely accepted methodology given its interdisciplinary approach and flexibility. This method represents a step forward in the field of renewable energy management, because it provides the possibility to compare the selected companies with the best in the industry (the most efficient and the possibility of determining sources of inefficiency and, consequently, the possibilities of their elimination.

  9. Mobile Learning as a Method of Ubiquitous Learning: Students' Attitudes, Readiness, and Possible Barriers to Implementation in Higher Education

    Science.gov (United States)

    Alhassan, Riyadh

    2016-01-01

    The purpose of this study was to explore the attitudes and level of readiness, and possible barriers to implementing Mobile Learning as a part of ubiquitous learning. In addition, the study attempted to find out to what extent students are interested in mobile learning. It also aimed to answer the question regarding the readiness of college…

  10. Possibilities for decreasing detection limits of analytical methods for determination of transformation products of unsymmetrical dimethylhydrazine in environmental samples

    Directory of Open Access Journals (Sweden)

    Bulat Kenessov

    2015-12-01

    Full Text Available Most rockets of middle and heavy class launched from Kazakhstan, Russia, China and other countries still use highly toxic unsymmetrical dimethylhydrazine (UDMH as a liquid propellant. Study of migration, distribution and accumulation of UDMH transformation products in environment and human health impact assessment of space rocket activity are currently complicated due to the absence of analytical methods allowing detection of trace concentrations of these compounds in analyzed samples. This paper reviews methods and approaches, which can be applied for development of such methods. Detection limits at a part-per-trillion (ppt level may be achieved using most selective and sensitive methods based on gas or liquid chromatography in combination of tandem or high-resolution mass spectrometry. In addition, 1000-fold concentration of samples or integrated sample preparation methods, e.g., dynamic headspace extraction, are required. Special attention during development and application of such methods must be paid to purity of laboratory air, reagents, glassware and analytical instruments.

  11. Advantages and Disadvantages of Possible Methods of Managing the Production on the Assembly Lines in the Given Company

    OpenAIRE

    Václavková, Eva

    2014-01-01

    The bachelor thesis deals with methods of lean management, more exactly production planning and managing the production lines assembly. In this thesis, production planning system, kanban cards and heijunka will be described. The aim of this thesis is to describe methods of managing the production lines assembly and to suggest more effective management.

  12. Possibilities and consequences of the Total Cumulative Exergy Loss method in improving the sustainability of power generation

    International Nuclear Information System (INIS)

    Stougie, Lydia; Kooi, Hedzer J. van der

    2016-01-01

    Highlights: • The TCExL method can be applied to all kinds of technological systems. • All exergy losses during the lifetime of a technological system are considered. • The results of the TCExL method are independent of time and weighting factors. • Applying the TCExL method can improve the sustainability of power generation. • The system with the lowest TCExL score is not always economically favourable. - Abstract: It is difficult to decide which power generation system is the most sustainable when environmental, economic and social sustainability aspects are taken into account. Problems with conventional environmental sustainability assessment methods are that no consensus exists about the applied models and weighting factors and that exergy losses are not considered. Economic sustainability assessment methods do not lead to results that are independent of time because they are influenced by market developments, while social sustainability assessment methods suffer from the availability and qualitative or semi-quantitative nature of data. Existing exergy analysis methods do not take into account all exergy losses and/or are extended with factors or equations that are not commonly accepted. The new Total Cumulative Exergy Loss (TCExL) method is based on fundamental thermodynamic equations and takes into account all exergy losses caused by a technological system during its life cycle, i.e. internal exergy losses, exergy losses caused by emission abatement and exergy losses related to land use. The development of the TCExL method is presented as well as the application of this method and environmental, economic and social sustainability assessment methods to two case studies: power generation in combination with LNG evaporation and Fossil versus renewable energy sources for power generation. According to the results of the assessments, large differences exist between the environmental sustainability assessment and TCExL methods in the sense that different

  13. 48 CFR 25.503 - Group offers.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Group offers. 25.503... PROGRAMS FOREIGN ACQUISITION Evaluating Foreign Offers-Supply Contracts 25.503 Group offers. (a) If the solicitation or an offer specifies that award can be made only on a group of line items or on all line items...

  14. 48 CFR 570.306 - Evaluating offers.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Evaluating offers. 570.306... Real Property 570.306 Evaluating offers. (a) You must evaluate offers solely in accordance with the... solicitation. The file must include the basis for evaluation, an analysis of each offer, and a summary of...

  15. 48 CFR 225.503 - Group offers.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Group offers. 225.503... OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Evaluating Foreign Offers-Supply Contracts 225.503 Group offers. Evaluate group offers in accordance with FAR 25.503, but apply the evaluation...

  16. Employer health insurance offerings and employee enrollment decisions.

    Science.gov (United States)

    Polsky, Daniel; Stein, Rebecca; Nicholson, Sean; Bundorf, M Kate

    2005-10-01

    To determine how the characteristics of the health benefits offered by employers affect worker insurance coverage decisions. The 1996-1997 and the 1998-1999 rounds of the nationally representative Community Tracking Study Household Survey. We use multinomial logistic regression to analyze the choice between own-employer coverage, alternative source coverage, and no coverage among employees offered health insurance by their employer. The key explanatory variables are the types of health plans offered and the net premium offered. The models include controls for personal, health plan, and job characteristics. When an employer offers only a health maintenance organization married employees are more likely to decline coverage from their employer and take-up another offer (odds ratio (OR)=1.27, phealth plan coverage an employer offers affects whether its employees take-up insurance, but has a smaller effect on overall coverage rates for workers and their families because of the availability of alternative sources of coverage. Relative to offering only a non-HMO plan, employers offering only an HMO may reduce take-up among those with alternative sources of coverage, but increase take-up among those who would otherwise go uninsured. By modeling the possibility of take-up through the health insurance offers from the employer of the spouse, the decline in coverage rates from higher net premiums is less than previous estimates.

  17. On the possibility of reprocessing of fuel elements of dispersion type with copper matrix by pyrochemical methods

    International Nuclear Information System (INIS)

    Vasin, B.D.; Ivanov, V.A.; Shchetinskij, A.V.; Vavilov, S.K.; Savochkin, Yu.P.; Bychkov, A.V.; Kormilitsyn, M.V.

    2005-01-01

    A consideration is given to pyrochemical processes suitable for separation of uranium dioxide from structural materials when reprocessing cermet type fuel elements. The estimation of the possibility to apply liquid antimony and bismuth, potassium and copper chlorides melts is made. The specimens compacted of copper and uranium dioxide powders in a stainless steel can are used as simulators of fuel element sections. It is concluded that the dissolution of structural materials in molten salts at the stage of uranium dioxide concentration is the process of choice for reprocessing of dispersion type fuel elements [ru

  18. Sport's offer as an instrument of sports marketing mix

    Directory of Open Access Journals (Sweden)

    Gašović Milan

    2004-01-01

    Full Text Available Taking logical postulate that a product is all what can be offered on the market in order to satisfy needs, demands or wants of customer, regarding the core of sport's offer (product, marketing experts must give answers to three key questions: What can sports companies, teams or individuals offer to consumer? What needs can sports companies, teams or individuals satisfy? What instruments (techniques and methods should use marketing experts in sports organizations in order to satisfy identified customer needs? .

  19. Assessment of the possibility of using data mining methods to predict sorption isotherms of selected organic compounds on activated carbon

    Directory of Open Access Journals (Sweden)

    Dąbek Lidia

    2017-01-01

    Full Text Available The paper analyses the use of four data mining methods (Support Vector Machines. Cascade Neural Networks. Random Forests and Boosted Trees to predict sorption on activated carbons. The input data for statistical models included the activated carbon parameters, organic substances and equilibrium concentrations in the solution. The assessment of the predictive abilities of the developed models was made with the use of mean absolute error (MAE, mean absolute percentage error (MAPE, and root mean squared error (RMSE. The computations proved that methods of data mining considered in the study can be applied to predict sorption of selected organic compounds 011 activated carbon. The lowest values of sorption prediction errors were obtained with the Cascade Neural Networks method (MAE = 1.23 g/g; MAPE = 7.90% and RMSE = 1.81 g/g, while the highest error values were produced by the Boosted Trees method (MAE=14.31 g/g; MAPE = 39.43% and RMSE = 27.76 g/g.

  20. Possibilities and scope of the double isotope effect method in the elucidation of mechanisms of enzyme catalyzed reactions

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, H L; Medina, R [Technische Univ. Muenchen, Freising (Germany, F.R.). Lehrstuhl fuer Allgemeine Chemie und Biochemie

    1991-01-01

    Kinetic isotope effects on enzyme catalyzed reactions are indicative for the first irreversible in a sequence of individual steps. Hints on the relative velocities of other steps can only be obtained from the partitioning factor R and its dependence on external reaction conditions. In general, the experimental data needed are obtained from isotope abundance measurements in a defined position of the substrate or product as a function of turnover. This method does not reveal events dealing with neighbour atoms or preceding the main isotope sensitive step. In the method presented here, the analytical measurement is extended to the second atom involved in a bond fission of formation (Double Isotope Effect Method). It is shown that the additional results obtained support the identification of the main isotopically sensitive step and its relative contribution to the overall reaction rate, the identification of other kinetically significant steps and the differentiation between stepwise and concerted reaction mechanisms. The method and its advantages are demonstrated on reactions comprising C-N-bond splitting (urease and arginase reaction), C-C-bound fission (reactions catalyzed by pyruvate-dehydrogenase, pyruvate-formiate-lyase and lactate-oxidase), C-O-bound formation (ribulose-bisphosphate-oxygenase reaction), and N-O-bond fission (nitrate- and nitrite-reductase reactions). (orig.).

  1. Comparison of Methods and Interdisciplinary Possibilities. The Case of Literature Reviews in Social Work and in Nursing Sciences

    Science.gov (United States)

    Couturier, Yves; Dumas-Laverdiere, Christian

    2006-01-01

    The reflections on interdisciplinarity cover several dimensions. One, among them, concerns the nature of what occurs between two disciplines. Does inter-disciplinarity relate to an intention, to a metatheory, to the object, or to a method? It is this ultimate space that we propose to study, supported by Reswebers (2000) proposition, putting the…

  2. The possibilities of the detection of boiling in the reactor core on the basis of acoustic emission method

    International Nuclear Information System (INIS)

    Liska, J.

    1978-01-01

    A method is described of detecting the crisis of boiling in the core of PWR type reactors which may lead to fuel element failure. The method can be applied both in reactor development and operation. It is based on boiling detection by acoustic emission testing. The acoustic signal is measured by means of a piezoelectric transducer immersed in water or attached to one end of a waveguide immersed in water. Signals may be measured in either a wide frequency range or in a band approaching the transducer resonance frequency. This is selected such as to be outside the noise band. Experiments in an open water tank and in a water loop showed that under favourable conditions, the acoustic emission testing method was very sensitive, the intensity of acoustic signals was proportional to boiling intensity, and information contained in the emission spectrum shape was primarily of a qualitative nature. The method remains to be tested in an actual reactor where many spurious noise sources exist. (O.K.)

  3. Outline of a method for final storage of low- and medium-active waste from possible Danish power reactors

    International Nuclear Information System (INIS)

    Brodersen, K.; Jensen, J.; Oestergaard, K.

    1977-02-01

    A method is outlined for the final storage of Danish low-and medium-active power reactor waste. The waste drums are contained in large concretre blocks placed just below the ground surface. A plant for storing waste by means of this method is sketched. It consists of a system of reinforced concrete pits with the top level with the ground surface. Each pit measures c. 5 x 5 m and is c. 6 m deep. The pits are envisaged cast with a permanent inside, step-like shuttering of thin steel plates. The volume between the drums will be cast with concrete when a pit is filled. Calculations are given of the construction and running costs. It is estimated that the final storage of reactor wastes is only a small problem regarding economy and space, and also that there is hardly doubt that full safety can be achieved. (B.P.)

  4. Possibility of determining the concentration of the gas phase in a two-phase stream by an acoustical method

    Energy Technology Data Exchange (ETDEWEB)

    Butenko, A N; Potapenko, A E; Chistyakov, E S

    1976-01-01

    The method is based on the recording of the amplitude-frequency characteristics of a circular piezoelectric resonator (sensor) during movement of a stream of a two-phase medium. It is shown that the electrical voltage drop across the transducer and the natural oscillating frequency of the transducer depend on the concentration of the gas phase in the two-phase mixture, allowing an instrument to be developed for measurement of this concentration.

  5. The importance of activity-based methods in radiology and the technology that now makes this possible.

    Science.gov (United States)

    Monge, Paul

    2006-01-01

    Activity-based methods serve as a dynamic process that has allowed many other industries to reduce and control their costs, increase productivity, and streamline their processes while improving product quality and service. The method could serve the healthcare industry in an equally beneficial way. Activity-based methods encompass both activity based costing (ABC) and activity-based management (ABM). ABC is a cost management approach that links resource consumption to activities that an enterprise performs, and then assigns those activities and their associated costs to customers, products, or product lines. ABM uses the resource assignments derived in ABC so that operation managers can improve their departmental processes and workflows. There are three fundamental problems with traditional cost systems. First, traditional systems fail to reflect the underlying diversity of work taking place within an enterprise. Second, it uses allocations that are, for the most part, arbitrary Single step allocations fail to reflect the real work-the activities being performed and the associate resources actually consumed. Third, they only provide a cost number that, standing alone, does not provide any guidance on how to improve performance by lowering cost or enhancing throughput.

  6. AGAPEROS Searches for microlensing in the LMC with the Pixel Method; 2, Selection of possible microlensing events

    CERN Document Server

    Melchior, A.L.; Ansari, R; Aubourg, E.; Baillon, P.; Bareyre, P.; Bauer, F.; Beaulieu, J.-Ph.; Bouquet, A.; Brehin, S.; Cavalier, F.; Char, S.; Couchot, F.; Coutures, C.; Ferlet, R.; Fernandez, J.; Gaucherel, C.; Giraud-Heraud, Y.; Glicenstein, J.-F.; Goldman, B.; Gondolo, P.; Gros, M.; Guibert, J.; Hardin, D.; Kaplan, J.; de Kat, J.; Lachieze-Rey, M.; Laurent, B; Lesquoy, E; Magneville, Ch.; Mansoux, B.; Marquette, J.-B.; Maurice, E.; Milsztajn, A.; Moniez, M.; Moreau, O.; Moscoso, L.; Palanque-Delabrouille, N.; Perdereau. O.; Prevot, L.; Renault, C.; Queinnec, F.; Rich, J.; Spiro, M.; Vidal-Madjar, A.; Vigroux, L.; Zylberajch, S.; Magneville, Ch.

    1998-01-01

    We apply the pixel method of analysis (sometimes called ``pixel lensing'') to a small subset of the EROS-1 microlensing observations of the bar of the Large Magellanic Cloud (LMC). The pixel method is designed to find microlensing events of unresolved source stars and had heretofore been applied only to M31 where essentially all sources are unresolved. With our analysis optimised for the detection of long-duration microlensing events due to 0.01-1 Mo Machos, we detect no microlensing events and compute the corresponding detection efficiencies. We show that the pixel method should detect 10 to 20 times more microlensing events for M>0.05 Mo Machos compared to a classical analysis of the same data which latter monitors only resolved stars. In particular, we show that for a full halo of Machos in the mass range 0.1 -- 0.5 Mo, a pixel analysis of the three-year EROS-1 data set covering 0.39 deg^2 would yield 4 events.

  7. Is it possible to predict the presence of colorectal cancer in a blood test? A probabilistic approach method.

    Science.gov (United States)

    Navarro Rodríguez, José Manuel; Gallego Plazas, Javier; Borrás Rocher, Fernando; Calpena Rico, Rafael; Ruiz Macia, José Antonio; Morcillo Ródenas, Miguel Ángel

    2017-10-01

    The assessment of the state of immunosurveillance (the ability of the organism to prevent the development of neoplasias) in the blood has prognostic implications of interest in colorectal cancer. We evaluated and quantified a possible predictive character of the disease in a blood test using a mathematical interaction index of several blood parameters. The predictive capacity of the index to detect colorectal cancer was also assessed. We performed a retrospective case-control study of a comparative analysis of the distribution of blood parameters in 266 patients with colorectal cancer and 266 healthy patients during the period from 2009 to 2013. Statistically significant differences (p indexes (neutrophil to lymphocyte ratio and platelet to lymphocyte ratio), hemoglobin, hematocrit and eosinophil levels. These differences allowed the design of a blood analytical profile that calculates the risk of colorectal cancer. This risk profile can be quantified via a mathematical formula with a probabilistic capacity to identify patients with the highest risk of the presence of colorectal cancer (area under the ROC curve = 0.85). We showed that a colorectal cancer predictive character exists in blood which can be quantified by an interaction index of several blood parameters. The design and development of interaction indexes of blood parameters constitutes an interesting research line for the development and improvement of programs for the screening of colorectal cancer.

  8. Newborn behaviour to locate the breast when skin-to-skin: a possible method for enabling early self-regulation.

    Science.gov (United States)

    Widström, A-M; Lilja, G; Aaltomaa-Michalias, P; Dahllöf, A; Lintula, M; Nissen, E

    2011-01-01

    The aim of this study was to provide a more detailed analysis of the infant's behavioural sequence that begins immediately after birth and terminates with grasping the nipple, suckling and then falling asleep. Twenty-eight full-term infants were videotaped immediately after birth. A video protocol was developed to examine infant behaviours identified from five random videotapes. When birth crying had stopped, the babies showed a short period of relaxation and then successively became alert. They went through an 'awakening phase', an 'active phase' with movements of limbs, rooting activity and looking at the mother's face, a 'crawling phase' with soliciting sounds, a 'familiarization phase' with licking of the areola, and a 'suckling phase' and last a 'sleeping phase'. Five factors related to the time spent to locate the breast: more number of looks at the breast 10-20 min after birth (p crawling (p = 0,0040); increased number of 'soliciting sounds' (p = 0.0022); and performing hand-breast-mouth movements (p = 0.0105) related to shorter time. Inborn breastfeeding reflexes were depressed at birth, possibly because of a depressed sensory system. It is hypothesized that when the infant is given the option to peacefully go through the nine behavioural phases birth cry, relaxation, awakening, activity, crawling, resting, familiarization, suckling and sleeping when skin-to-skin with its mother this results in early optimal self-regulation. © 2010 The Author(s)/Acta Paediatrica © 2010 Foundation Acta Paediatrica.

  9. CURRICULAR OFFER INFLUENCING STUDENTS’ SATISFACTION: COMPARATIVE STUDY

    Directory of Open Access Journals (Sweden)

    Oana DUMITRASCU

    2014-11-01

    Full Text Available The main objective of the study is the determination of students’ satisfaction regarding curricular activities. The study has been accomplished using the qualitative and quantitative research, using the bibliographic study, various secondary sources and different primary sources. The study is developed with a marketing research and accomplished using the survey method. 699 students from four universities have been questioned. Due to a comparative study the University of Applied Sciences Worms, University of Applied Sciences Wiesbaden Rüsselsheim, University of Applied Sciences Frankfurt am Main and Nürtingen-Geislingen University have been analysed and their similarities and differences have been identified. The collected data, based on the established sample, is evaluated through univariate and bivariate analysis. In accordance with the evaluated sample, specific gaps from each region are identified regarding the curricular offer of the analysed universities. As a result to the conducted study, recommendations for the University of Applied Sciences Worms regarding the student’s satisfaction concerning the curricular offer are presented.

  10. Economic Dispatch of Demand Response Balancing through Asymmetric Block Offers

    DEFF Research Database (Denmark)

    O'Connell, Niamh; Pinson, Pierre; Madsen, Henrik

    2015-01-01

    This paper proposes a method of describing the load shifting ability of flexible electrical loads in a manner suitable for existing power system dispatch frameworks. The concept of an asymmetric block offer for flexible loads is introduced. This offer structure describes the ability of a flexible...

  11. Possibilities of Formation of Dioxins and Furans in Metallurgical Processes as well as Methods of their Reduction

    Directory of Open Access Journals (Sweden)

    Holtzer, M.

    2007-01-01

    Full Text Available The metallurgical industry, among others, generates various kinds of wastes: gaseous, dusts, wastes and sewage. Special attention of the European Union is directed towards the elimination or significant reduction of the gaseous-dust contamination emissions including the most hazardous compounds, such as dioxins and furans. In the article the sources of dioxins and furans in metallurgical industry are described along with the reduction methods of these pollutants. Particularly the activities recommended as the Best Available Techniques (BAT in order to reduce the PCDD/PCDF emission from sintering processes, non-ferrous metallurgy and foundry engineering have been presented.

  12. 17 CFR 230.253 - Offering circular.

    Science.gov (United States)

    2010-04-01

    .... Repetition of information should be avoided; cross-referencing of information within the document is... COMPLETENESS OF ANY OFFERING CIRCULAR OR OTHER SELLING LITERATURE. THESE SECURITIES ARE OFFERED PURSUANT TO AN...

  13. A method to associate all possible combinations of genetic and environmental factors using GxE landscape plot.

    Science.gov (United States)

    Nagaie, Satoshi; Ogishima, Soichi; Nakaya, Jun; Tanaka, Hiroshi

    2015-01-01

    Genome-wide association studies (GWAS) and linkage analysis has identified many single nucleotide polymorphisms (SNPs) related to disease. There are many unknown SNPs whose minor allele frequencies (MAFs) as low as 0.005 having intermediate effects with odds ratio between 1.5~3.0. Low frequency variants having intermediate effects on disease pathogenesis are believed to have complex interactions with environmental factors called gene-environment interactions (GxE). Hence, we describe a model using 3D Manhattan plot called GxE landscape plot to visualize the association of p-values for gene-environment interactions (GxE). We used the Gene-Environment iNteraction Simulator 2 (GENS2) program to simulate interactions between two genetic loci and one environmental factor in this exercise. The dataset used for training contains disease status, gender, 20 environmental exposures and 100 genotypes for 170 subjects, and p-values were calculated by Cochran-Mantel-Haenszel chi-squared test on known data. Subsequently, we created a 3D GxE landscape plot of negative logarithm of the association of p-values for all the possible combinations of genetic and environmental factors with their hierarchical clustering. Thus, the GxE landscape plot is a valuable model to predict association of p-values for GxE and similarity among genotypes and environments in the context of disease pathogenesis. GxE - Gene-environment interactions, GWAS - Genome-wide association study, MAFs - Minor allele frequencies, SNPs - Single nucleotide polymorphisms, EWAS - Environment-wide association study, FDR - False discovery rate, JPT+CHB - HapMap population of Japanese in Tokyo, Japan - Han Chinese in Beijing.

  14. A study of the process of two staged anaerobic fermentation as a possible method for purifying sewage

    Energy Technology Data Exchange (ETDEWEB)

    Inoue, Y; Kouama, K; Matsuo, T

    1983-01-01

    Great attention has recently been given to the study of the processes of anaerobic fermentation, which may become alternatives to the existing methods for purifying waste waters which use aerobic microorganisms. A series of experimentswere conducted with the use of an artificially prepared liquid (fermented milk and starch) which imitates the waste to be purified, in order to explain the capabilities of the process of two staged anaerobic fermentation (DAS) as a method for purifying waste waters. The industrial system of the process includes: a fermentation vat for acetic fermentation with recirculation of the sediment, a primary settler, a fermentation tank for methane fermentation and a secondary settler. The process was conducted at a loading speed (based on Carbon) from 0.15 to 0.4 kilograms per cubic meter per day at a temperature of 38C. The degree of conversion of the fermented organic substances into volatile organic acids was not a function of the loading speed and was 54 to 57 percent in the acetic fermentation tank, where 95 to 97 percent of the organic material was broken down with the production of methane and carbon dioxide.

  15. Ultra-fast DNA-based multiplex convection PCR method for meat species identification with possible on-site applications.

    Science.gov (United States)

    Song, Kyung-Young; Hwang, Hyun Jin; Kim, Jeong Hee

    2017-08-15

    The aim of this study was to develop an ultra-fast molecular detection method for meat identification using convection Palm polymerase chain reaction (PCR). The mitochondrial cytochrome b (Cyt b) gene was used as a target gene. Amplicon size was designed to be different for beef, lamb, and pork. When these primer sets were used, each species-specific set specifically detected the target meat species in singleplex and multiplex modes in a 24min PCR run. The detection limit was 1pg of DNA for each meat species. The convection PCR method could detect as low as 1% of meat adulteration. The stability of the assay was confirmed using thermal processed meats. We also showed that direct PCR can be successfully performed with mixed meats and food samples. These results suggest that the developed assay may be useful in the authentication of meats and meat products in laboratory and rapid on-site applications. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. INTERCULTURAL ISSUES OF THE TOURIST OFFER

    Directory of Open Access Journals (Sweden)

    Cristina Elena ALBU

    2015-03-01

    Full Text Available Tourism is an opportunity for people from different cultures to meet and interact, to exchange ideas, traditions and ways of thinking. In this industry it is very easy to judge a person just after taking an overall look and studying her general behavior. The aim of this article is to determine the intercultural issues that can show up during the tourist act, while people belonging to different cultures interact. The research method used for creating this article is documentary study. The tourist offer shall be adapted to different types of tourist, taking into consideration some aspects as tourists’ behavior, the type of tourism they prefer and, most of all, the culture they belong to and the culture of the people from the place they visit. Despite the immense diversity of our minds, there is a structure that can serve as a basis for mutual understanding.

  17. 43 CFR 12.715 - Evaluating offers.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Evaluating offers. 12.715 Section 12.715... Act-Supplies § 12.715 Evaluating offers. (a) Unless the head of the grantee organization or a designee at a level no lower than the grantee's designated awarding official determines otherwise, the offered...

  18. 5 CFR 536.104 - Reasonable offer.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Reasonable offer. 536.104 Section 536.104... Provisions § 536.104 Reasonable offer. (a) For the purpose of determining whether grade retention eligibility or entitlement must be terminated under § 536.207 or 536.208, the offer of a position is a reasonable...

  19. 7 CFR 3560.656 - Incentives offers.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Incentives offers. 3560.656 Section 3560.656... AGRICULTURE DIRECT MULTI-FAMILY HOUSING LOANS AND GRANTS Housing Preservation § 3560.656 Incentives offers. (a) The Agency will offer a borrower, who submits a prepayment request meeting the conditions of § 3560...

  20. 48 CFR 12.205 - Offers.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Offers. 12.205 Section 12... ACQUISITION OF COMMERCIAL ITEMS Special Requirements for the Acquisition of Commercial Items 12.205 Offers. (a) Where technical information is necessary for evaluation of offers, agencies should, as part of market...

  1. 32 CFR 536.64 - Final offers.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Final offers. 536.64 Section 536.64 National... UNITED STATES Investigation and Processing of Claims § 536.64 Final offers. (a) When claims personnel... less than the amount claimed, a settlement authority will make a written final offer within his or her...

  2. The primary relevance of subconsciously offered attitudes

    DEFF Research Database (Denmark)

    Kristiansen, Tore

    2015-01-01

    ) and subconsciously (covertly) offered attitudes – because subconsciously offered attitudes appear to be a driving force in linguistic variation and change in a way that consciously offered attitudes are not. The argument is based on evidence from empirical investigations of attitudes and use in the ‘...

  3. Innovative gas offers; Les offres gazieres innovantes

    Energy Technology Data Exchange (ETDEWEB)

    Sala, O.; Mela, P. [Gaz de France (GDF), 75 - Paris (France); Chatelain, F. [Primagaz, 75 - Paris (France)

    2007-07-01

    New energy offers are progressively made available as the opening of gas market to competition becomes broader. How are organized the combined offers: gas, electricity, renewable energies and energy services? What are the marketing strategies implemented? Three participants at this round table present their offer and answer these questions. (J.S.)

  4. Offer patterns of nationally placed livers by donation service area.

    Science.gov (United States)

    Lai, Jennifer C; Feng, Sandy; Vittinghoff, Eric; Roberts, John P

    2013-04-01

    We previously reported that national liver distribution is highly concentrated in 6 US centers, and this raises the possibility of expedited placement. Therefore, we evaluated all national offers of nationally placed livers (n=1625) to adult wait-list candidates from February 2005 to January 2010. We developed a model to predict national utilization pathways; pathways exceeding the best-fit linear unbiased predictions by ≥3 standard errors were defined as preferred. All 51 donation service areas (DSAs) placed 1 or more livers nationally, but the percentage per DSA ranged from 1% to 36%. Of 2830 possible national DSA-center pathways, 87% were used. Five hundred eighty livers (36%) were accepted on the first national offer. Four DSAs accounted for 47% of first-national-offer livers, and 44% of these were accepted by a single center. In comparison with first-offer livers using nonpreferred pathways, first offers along a preferred pathway were offered to fewer status 1 candidates (19% versus 61%) and had lower median model for end-stage liver disease (MELD) scores (22 versus 36, Poffer to non-status 1 candidates with MELD scores less than their local transplant MELD scores. Although this practice may facilitate liver placement, it raises the possibility of expedience trumping patient need. Here we propose changes to the national liver distribution system that will help to balance equity, efficiency, and transparency. Copyright © 2013 American Association for the Study of Liver Diseases.

  5. [The receptorial responsiveness method (RRM): a new possibility to estimate the concentration of pharmacologic agonists at their receptors].

    Science.gov (United States)

    Pák, Krisztián; Kiss, Zsuzsanna; Erdei, Tamás; Képes, Zita; Gesztelyi, Rudolf

    2014-01-01

    Cardiovascular disease is the biggest challenge in terms of life expectancy in developed countries. Adenosine contributes to the adaptation of the heart to ischemia and hypoxia, because adenosine, in addition to its metabolite role in the nucleic acid metabolism, is the endogenous agonist of the ubiquitous adenosine receptor family. Adenosine receptor activation is beneficial in most cases, it improves the balance between energy supply and consumption, reduces injury caused by stressors and inhibits the unfavorable tissue remodeling. Pharmacological manipulation of cardioprotective effects evoked by adenosine is an important, although to date not sufficiently utilized endeavor that may have therapeutic and preventive implications in cardiovascular diseases. As the ligand binding site of adenosine receptors is accessible from the extracellular space, it is especially important to know the adenosine concentration of the interstitial fluid ([Ado](ISF)). However, in the functioning heart, [Ado](ISF) values range in an extremely wide interval, spanning from nano- to micromolar concentrations, as estimated by the commonly used methods. Our recently developed procedure, the receptorial responsiveness method (RRM), may resolve this problem in certain cases. RRM enables quantification of an acute increase in the concentration of a pharmacological agonist, uniquely in the microenvironment of the receptors of the given agonist. As a limitation, concentration of agonists with short half-life (just like adenosine) at their receptors can only be quantified with the equieffective concentration of a stable agonist exerting the same action. In a previous study using RRM, inhibition of the transmembrane nucleoside transport in the euthyroid guinea pig atrium produced an increase in [Ado](ISF) that was equieffective with 18.8 +/- 3 nM CPA (N6-cyclopentyladenosine, a stable, selective A1 adenosine receptor agonist). This finding is consistent with observations of others, i.e., in the

  6. A study of electrochemical precipitation as a possible method of removing radium from uranium industry liquid wastes

    International Nuclear Information System (INIS)

    Paiva, M.I.F. de

    1996-09-01

    Of the various dissolved species contained in the effluents from the mining and milling of uranium ores, the one which is of particular concern for environmental protection is Radium-226. The literature shows that, in recent years, considerable efforts have been made to develop treatment systems that can achieve the stricter effluent discharge standards imposed by the regulatory bodies. There has also been a concern to treat the already existent sludges from previous treatments. The main priority is to limit, as much as possible, the arising of sludge from future treatment systems. The most common treatment used is the addition of lime and limestone to raise the pH followed by barium chloride to form a very finely divided Ba(Ra)SO 4 precipitate which is then settled in large ponds or basins. In spite of the high decontamination factors obtained with this technique, these may not be satisfactory in terms of environmental protection. In addition, the industry is increasingly aware of the economical benefits resulting from treatment processes that allow water reuse to the process. The main objectives of this work were to carry out a fundamental study of a new technique, Electrochemical Precipitation, and assess its viability to remove undesirable ions from liquid solutions, in this particular case, radium from liquid wastes resulting from the milling of uranium ores. To achieve the proposed objectives, research was carried out using strontium sulphate precipitative membranes combined with an electrical field. Barium was used as a target ion due to its similarity to radium and no radioactive characteristics. The process studied, combines electrical ionic transport and selective precipitation, which relies on a solubility difference between the inorganic membrane and the ions to be separated. This study investigated different parameters involved in the process such as flowrate, current density, different cell geometries and the gap between half cells (internal volume of

  7. Probing of possible olanzapine binding site on human serum albumin: Combination of spectroscopic methods and molecular dynamics simulation

    International Nuclear Information System (INIS)

    Shahlaei, Mohsen; Rahimi, Behnoosh; Ashrafi-Kooshk, Mohammad Reza; Sadrjavadi, Komail; Khodarahmi, Reza

    2015-01-01

    Human serum albumin (HSA)-drug binding affinity is one of the major factors that determine the pharmacokinetics, halftime and bioavailability of drugs in various tissues. In the present study, the interaction of olanzapine (OLZ), a thienobenzodiazepine drug, administered for the treatment of schizophrenia and bipolar disorder, with HSA has been studied using spectroscopic methods such as ultraviolet absorbance, fluorescence and FTIR combined with computational procedures. Analyzing of the Stern–Volmer quenching data showed only one primary binding site on HSA with a binding constant of 4.12×10 4 M −1 at 298 K. Thermodynamic analyses showed enthalpy change (ΔH°) and entropy change (ΔS°) were 28.03±3.42 kJ mol −1 and −25.52±11.52 J mol −1 K −1 , respectively. Molecular docking results suggested the hydrophobic residues such as Val 216 , Leu 327 , Ala 350 and polar residues such as Glu 354 play an important role in the drug binding. Decrement in α-helix content of the protein upon OLZ binding was also confirmed by evidences provided by molecular dynamics simulation as well as FTIR spectroscopy. - Highlights: • Leu 327 , Ala 350 as well as hydrophilic residues of HSA play an important role in the binding reaction. • The drug has only one primary binding site on HSA with a binding constant of 4.12×10 4 M −1 at 298 K. • The drug binds near to site I

  8. Probing of possible olanzapine binding site on human serum albumin: Combination of spectroscopic methods and molecular dynamics simulation

    Energy Technology Data Exchange (ETDEWEB)

    Shahlaei, Mohsen, E-mail: mohsenshahlaei@yahoo.com [Nano drug delivery research Center, Research Center, Kermanshah University of Medical Sciences, Kermanshah (Iran, Islamic Republic of); Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah (Iran, Islamic Republic of); Rahimi, Behnoosh [Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah (Iran, Islamic Republic of); Student research committee, Kermanshah University of Medical Sciences, Kermanshah (Iran, Islamic Republic of); Ashrafi-Kooshk, Mohammad Reza [Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah (Iran, Islamic Republic of); Sadrjavadi, Komail [Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah (Iran, Islamic Republic of); Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah (Iran, Islamic Republic of); Khodarahmi, Reza, E-mail: rkhodarahmi@mbrc.ac.ir [Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah (Iran, Islamic Republic of); Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah (Iran, Islamic Republic of)

    2015-02-15

    Human serum albumin (HSA)-drug binding affinity is one of the major factors that determine the pharmacokinetics, halftime and bioavailability of drugs in various tissues. In the present study, the interaction of olanzapine (OLZ), a thienobenzodiazepine drug, administered for the treatment of schizophrenia and bipolar disorder, with HSA has been studied using spectroscopic methods such as ultraviolet absorbance, fluorescence and FTIR combined with computational procedures. Analyzing of the Stern–Volmer quenching data showed only one primary binding site on HSA with a binding constant of 4.12×10{sup 4} M{sup −1} at 298 K. Thermodynamic analyses showed enthalpy change (ΔH°) and entropy change (ΔS°) were 28.03±3.42 kJ mol{sup −1} and −25.52±11.52 J mol{sup −1} K{sup −1}, respectively. Molecular docking results suggested the hydrophobic residues such as Val{sub 216}, Leu{sub 327}, Ala{sub 350} and polar residues such as Glu{sub 354} play an important role in the drug binding. Decrement in α-helix content of the protein upon OLZ binding was also confirmed by evidences provided by molecular dynamics simulation as well as FTIR spectroscopy. - Highlights: • Leu{sub 327}, Ala{sub 350} as well as hydrophilic residues of HSA play an important role in the binding reaction. • The drug has only one primary binding site on HSA with a binding constant of 4.12×10{sup 4} M{sup −1} at 298 K. • The drug binds near to site I.

  9. Antifungal Susceptibility Testing of Aspergillus spp. by Using a Composite Correlation Index (CCI)-Based Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry Method Appears To Not Offer Benefit over Traditional Broth Microdilution Testing.

    Science.gov (United States)

    Gitman, Melissa R; McTaggart, Lisa; Spinato, Joanna; Poopalarajah, Rahgavi; Lister, Erin; Husain, Shahid; Kus, Julianne V

    2017-07-01

    Aspergillus spp. cause serious invasive lung infections, and Aspergillus fumigatus is the most commonly encountered clinically significant species. Voriconazole is considered to be the drug of choice for treating A. fumigatus infections; however, rising resistance rates have been reported. We evaluated a matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS)-based method for the differentiation between wild-type and non-wild-type isolates of 20 Aspergillus spp. (including 2 isolates of Aspergillus ustus and 1 of Aspergillus calidoustus that were used as controls due their intrinsic low azole susceptibility with respect to the in vitro response to voriconazole). At 30 and 48 h of incubation, there was complete agreement between Cyp51A sequence analysis, broth microdilution, and MALDI-TOF MS classification of isolates as wild type or non-wild type. In this proof-of-concept study, we demonstrated that MALDI-TOF MS can be used to accurately detect A. fumigatus strains with reduced voriconazole susceptibility. However, rather than proving to be a rapid and simple method for antifungal susceptibility testing, this particular MS-based method showed no benefit over conventional testing methods. © Crown copyright 2017.

  10. Antifungal Susceptibility Testing of Aspergillus spp. by Using a Composite Correlation Index (CCI)-Based Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry Method Appears To Not Offer Benefit over Traditional Broth Microdilution Testing

    Science.gov (United States)

    Gitman, Melissa R.; McTaggart, Lisa; Spinato, Joanna; Poopalarajah, Rahgavi; Lister, Erin; Husain, Shahid

    2017-01-01

    ABSTRACT Aspergillus spp. cause serious invasive lung infections, and Aspergillus fumigatus is the most commonly encountered clinically significant species. Voriconazole is considered to be the drug of choice for treating A. fumigatus infections; however, rising resistance rates have been reported. We evaluated a matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS)-based method for the differentiation between wild-type and non-wild-type isolates of 20 Aspergillus spp. (including 2 isolates of Aspergillus ustus and 1 of Aspergillus calidoustus that were used as controls due their intrinsic low azole susceptibility with respect to the in vitro response to voriconazole). At 30 and 48 h of incubation, there was complete agreement between Cyp51A sequence analysis, broth microdilution, and MALDI-TOF MS classification of isolates as wild type or non-wild type. In this proof-of-concept study, we demonstrated that MALDI-TOF MS can be used to accurately detect A. fumigatus strains with reduced voriconazole susceptibility. However, rather than proving to be a rapid and simple method for antifungal susceptibility testing, this particular MS-based method showed no benefit over conventional testing methods. PMID:28404678

  11. Marketing strategy to differentiate the offer

    OpenAIRE

    Miceski, Trajko; Pasovska, Silvana

    2013-01-01

    The marketing strategy for differentiation of the offers is important and accepted strategy especially by the bigger legal entities. The differentiation of the offers leads to bigger profit and bigger profitability in operation, through targeting of the demand towards the product of the enterprise. The vertical differentiation of the offers is directed towards the quality of the product itself which is observed as a something superior despite the competitive product which is observed as somet...

  12. Flightless mutants in the melon fly and oriental fruit fly (Diptera: Tephritidae) and their possible role in the sterile insect release method

    International Nuclear Information System (INIS)

    McCombs, S.D.; Saul, S.H.

    1992-01-01

    Two new mutants that affect adult wing morphology and render the flies incapable of flight.sbd.bubble wing (bw) in the melon fly, Bactrocera cucurbitae (Coquillett), and small wing (sw) in the oriental fruit fly, Bactrocera dorsalis (Hendel).sbd.are described. Both mutants have variable expression and are caused by autosomal, recessive genes. We discuss the possible role of these alleles in constructing genetic sex sorting systems to improve the effectiveness and efficiency of the sterile insect release method

  13. 12 CFR 335.501 - Tender offers.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Tender offers. 335.501 Section 335.501 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY SECURITIES OF NONMEMBER INSURED BANKS § 335.501 Tender offers. The provisions of the applicable and currently...

  14. 43 CFR 12.815 - Evaluating offers.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Evaluating offers. 12.815 Section 12.815 Public Lands: Interior Office of the Secretary of the Interior ADMINISTRATIVE AND AUDIT REQUIREMENTS AND... Act-Construction Materials § 12.815 Evaluating offers. (a) The restrictions of the Buy American Act do...

  15. 48 CFR 2825.203 - Evaluating offers.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Evaluating offers. 2825.203 Section 2825.203 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE Socioeconomic Programs FOREIGN ACQUISITION Buy American Act-Construction Materials 2825.203 Evaluating offers. The HCA, or...

  16. Industrial Heritage in Tuzla Canton Tourist Offer

    Directory of Open Access Journals (Sweden)

    Edin Jahić

    2014-04-01

    Full Text Available Industrial heritage has a great importance in development of tourism of Tuzla Canton because this is a region which had well developed industry in the past. Major part of this industry has been destroyed and now can be used for touristic purposes Besides this function, industrial plants can be used for development of culture, education, etc., and we already have such positive examples in wealthier European countries. The aim of the survey was to examine the opinion of tourist agencies, which are providers of tourist services, on further development of tourism in the region of Tuzla Canton, with special emphasis on industrial tourism, because tourist agencies are one of the key factors in creation of tourism development. Methods used for data collecting, processing and analysis are: historical, descriptive, comparative, case study, survey (SPSS version 20. Elements that need improving and further development are highlighted. The research results can help the tourist destination management, in this case TC, but also all segments of the tourism industry of TC, improve their offer and communication with a potential tourism market.

  17. 12 CFR 563g.21 - Filing of copies of offering circulars in certain exempt offerings.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Filing of copies of offering circulars in certain exempt offerings. 563g.21 Section 563g.21 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY SECURITIES OFFERINGS § 563g.21 Filing of copies of offering circulars in certain...

  18. Hospitalized Patients' Responses to Offers of Prayer.

    Science.gov (United States)

    McMillan, Kathy; Taylor, Elizabeth Johnston

    2018-02-01

    Most Americans pray; many pray about their health. When they are hospitalized, however, do patients want an offer of prayer from a healthcare provider? This project allowed for the measurement of hospitalized patient's responses to massage therapists' offers of a colloquial prayer after a massage. After the intervention, 78 patients completed questionnaires that elicited quantitative data that were analyzed using uni- and bivariate statistical analyses. In this sample, 88% accepted the offer of prayer, 85% found it helpful, and 51% wanted prayer daily. Patients may welcome prayer, as long as the clinician shows "genuine kindness and respect."

  19. What serious video games can offer child obesity prevention.

    Science.gov (United States)

    Thompson, Debbe

    2014-07-16

    Childhood obesity is a worldwide issue, and effective methods encouraging children to adopt healthy diet and physical activity behaviors are needed. This viewpoint addresses the promise of serious video games, and why they may offer one method for helping children eat healthier and become more physically active. Lessons learned are provided, as well as examples gleaned from personal experiences.

  20. What serious video games can offer child obesity prevention

    Science.gov (United States)

    Childhood obesity is a worldwide issue, and effective methods encouraging children to adopt healthy diet and physical activity behaviors are needed. This viewpoint addresses the promise of serious video games, and why they may offer one method for helping children eat healthier and become more physi...

  1. 16 CFR 238.2 - Initial offer.

    Science.gov (United States)

    2010-01-01

    ... § 238.2 Initial offer. (a) No statement or illustration should be used in any advertisement which creates a false impression of the grade, quality, make, value, currency of model, size, color, usability...

  2. Sustainable Offering Practices Through Stakeholders Engagement

    Directory of Open Access Journals (Sweden)

    Bijay Prasad Kushwaha

    2018-02-01

    Full Text Available Sustainable development is achieved by satisfying the current ends without shrinking the existing means which can serve as needs for the society in the future. It has become global motive and responsibility of present community to utilize resources in an optimum way with minimum environmental damage. The objective of this paper is to study theoretical framework and practical approaches on sustainable offering practices through customer engagement. The study has also examined the opportunities and challenges of sustainable offering practices in India. The study is based on a previous study and secondary data has been used for analysis. The outcome revealed the process for successful sustainable offering practices in context of Indian consumers. The analysis has helped to understand different practices of sustainable offering through engaging stakeholders.

  3. The Possibility of Using Monte Carlo Method in the Case of Decision-Making under Conditions of Risk Concerning an Agricultural Economics Issue

    Directory of Open Access Journals (Sweden)

    Dominika Crnjac Milić

    2013-07-01

    Full Text Available Monte Carlo method is a probabilistic computer algorithm in which the value of one or more random variables is given by the density function, and the goal of which is to predict all the possible outcomes of a process it has been applied to and the probability of their occurrence. As such, the Monte Carlo method proves to be extremely useful in the process of decision- making under conditions of risk. This paper discusses an example of function optimization with the aim of finding a solution that will deliver the highest profits in the described agricultural economics-related problem under risk-free conditions. A Monte Carlo simulation is carried out and the solution under conditions of risk is also found. For that purpose, a special program code was written.

  4. The CT (Hounsfield unit) number of brain tissue in healthy infants. A new reliable method for detection of possible degenerative disease.

    Science.gov (United States)

    Boris, P; Bundgaard, F; Olsen, A

    1987-01-01

    It is difficult to correlate CT Hounsfield unit (H. U.) numbers from one CT investigation to another and from one CT scanner to another, especially when dealing with small changes in the brain substance, as in degenerative brain diseases in children. By subtracting the mean value of cerebrospinal fluid (CSF) from the mean value of grey and white matter, it is possible to remove most of the errors due, for example, to maladjustments, short and long-term drift, X-ray fan, and detector asymmetry. Measurements of white and grey matter using these methods showed CT H. U. numbers changing from 15 H. U. to 22 H. U. in white matter and 23 H. U. to 30 H. U. in grey matter in 86 healthy infants aged 0-5 years. In all measurements, the difference between grey and white matter was exactly 8 H. U. The method has proven to be highly accurate and reproducible.

  5. New fusion method offers hope of new energy source

    CERN Multimedia

    Chang, K

    2002-01-01

    Scientists from Sandia National Laboratories have reported that they have acheived thermonuclear fusion using the Z accelerator. It is the first observation of fusion using a pulsed power source (1 page).

  6. A multidisciplinary approach for the study of the effects of active tectonics along the North Anatolian fault zone: possibilities for the application of the electrical self potential method

    Directory of Open Access Journals (Sweden)

    W. Balderer

    1994-06-01

    Full Text Available The aims of this joint interdisciplinary project “Marmara” of ETH Zurich and the Istanbul Technical University (ITO are to study the effects of active tectonics as evidenced by geology, geodesy and seismology on hydrogeology and geothermics in selected areas along the North Anatolian fault zone. Within the framework of this project thermal water systems in seven different areas have been investigated or are under investigation up to now (SchindIer et al., 1993. For three study areas along the North Anatolian fault zone (from east to west of Kuzuluk/Adapazari, Bursa and of Canakkale the investigations with respect to the geological and hydrogeological features are complete. The now possible hydrogeological characterisation shows encouraging possibilities for the application of new methods like the electrical self potential method for the following reasons: 1 a fully interdisciplinary approach, including seismic survey with especially conceived network, geodetic survey to investigate tectonic movements by the GPS method, geothermic survey combined with geological mapping and hydrogeological investigations of normal mineral and thermal waters; 2 groundwaters of very different chemical and isotopical composition e.g.: Ca-HCO3-type thermal waters of up to 82 °C temperature and total mineralisation of 500 mg/I to 1500 mg/I in the Bursa area, Na-HCO3-type cold mineral waters of up to 2500 mg/I to thermal waters of same mineralisation of up to 80 °C temperature, containing large amounts of CO2 of up to 1 l per 1 kg of water (at surface conditions in the Kuzuluk area and Na-Cl-type waters presenting real thermal brines of up to 65 000 mg/I of total mineralisation and temperatures of up to 100 °C in the Canakkale area; 3 distinct types of hydrodynamic flow regime in areas of different geological and tectonic structure. Based on the results of the investigations within these areas the possibilities of further studies including self potential methods

  7. The ultimatum game: Discrete vs. continuous offers

    Science.gov (United States)

    Dishon-Berkovits, Miriam; Berkovits, Richard

    2014-09-01

    In many experimental setups in social-sciences, psychology and economy the subjects are requested to accept or dispense monetary compensation which is usually given in discrete units. Using computer and mathematical modeling we show that in the framework of studying the dynamics of acceptance of proposals in the ultimatum game, the long time dynamics of acceptance of offers in the game are completely different for discrete vs. continuous offers. For discrete values the dynamics follow an exponential behavior. However, for continuous offers the dynamics are described by a power-law. This is shown using an agent based computer simulation as well as by utilizing an analytical solution of a mean-field equation describing the model. These findings have implications to the design and interpretation of socio-economical experiments beyond the ultimatum game.

  8. NANOMEDICINE: will it offer possibilities to overcome multiple drug resistance in cancer?

    Science.gov (United States)

    Friberg, Sten; Nyström, Andreas M

    2016-03-09

    This review is written with the purpose to review the current nanomedicine literature and provide an outlook on the developments in utilizing nanoscale drug constructs in treatment of solid cancers as well as in the potential treatment of multi-drug resistant cancers. No specific design principles for this review have been utilized apart from our active choice to avoid results only based on in vitro studies. Few drugs based on nanotechnology have progressed to clinical trials, since most are based only on in vitro experiments which do not give the necessary data for the research to progress towards pre-clinical studies. The area of nanomedicine has indeed spark much attention and holds promise for improved future therapeutics in the treatment of solid cancers. However, despite much investment few targeted therapeutics have successfully progressed to early clinical trials, indicating yet again that the human body is complicated and that much more understanding of the fundamentals of receptor interactions, physics of nanomedical constructs and their circulation in the body is indeed needed. We believe that nanomedical therapeutics can allow for more efficient treatments of resistant cancers, and may well be a cornerstone for RNA based therapeutics in the future given their general need for shielding from the harsh environment in the blood stream.

  9. Thermal expression of intersubjectivity offers new possibilities to human-machine and technologically mediated interactions

    Directory of Open Access Journals (Sweden)

    Arcangelo eMerla

    2014-07-01

    Full Text Available The evaluation of the psychophysiological state of the interlocutor is an important element of interpersonal relationships and communication. Thermal infrared imaging has proved to be a reliable tool for non-invasive and contact-less evaluation of vital signs, psychophysiological responses and emotional states. This technique is quickly spreading in many fields, from psychometrics to social and developmental psychology; and from the touch-less monitoring of vital signs and stress, up to the human-machine interaction. In particular, thermal IR imaging promises to be of use for gathering information about affective states in social situations. This paper presents the state of the art of thermal infrared imaging in psychophysiology and in the assessment of affective states. The goal is to provide insights about its potentialities and limits for its use in human-artificial agent interaction in order to contribute to a major issue in the field: the perception by an artificial agent of human psychophysiological and affective states.

  10. Interfunctional Coordination of Service Offering Provided by Manufacturers

    OpenAIRE

    Kanovska, Lucie; Tomaskova, Eva

    2017-01-01

    Interfunctional coordination (IFC) aims to develop cooperation between the different departments of a company. Services offered by companies increase customer orientation of a company and help satisfy its customers. IFC and cus-tomer orientation are the main parts of market orientation. Market orientation is one of many possible ways how to in-crease business performance and competitiveness of companies. The aim of the paper is to describe main findings of the research, which was focused on r...

  11. Analysis of possible application of regression analysis method in automation of fitting numerical data; Analiza mogucnosti primene metoda regresione analize u cilju automatizovanog fitovanja numerickih podataka

    Energy Technology Data Exchange (ETDEWEB)

    Altiparmakov, D; Zavaljevski, N; Dasic, N [Boris Kidric Institute of Nuclear Sciences Vinca, Beograd (Yugoslavia)

    1988-12-15

    The report presents an analysis of possible calculation procedure for automated data fitting. The problem is defined in the first part, and it is shown that solution demands optimisation under invariance conditions (stochastic errors) which is part of theory of planning optimal experiments. A rough review of knowledge in this field is given. Second part of the report some statistical and optimisation methods are analysed in more detail in order to be used for automated fitting. Evaluation of possible relevant calculation procedure is presented. Izvestaj prikazuje analizu mogucnosti realizacije racunskog postupka za automatizovano fitovanje poodataka. U prvom delu izvestaja razmatran je postavljeni problem i ukazano je da njegovo resavanje zahteva optimizaciju u uslovima neodredjenosti (slucajnih gresaka) sto spada u okvir teorije planiranja optimalnih eksperimenata. Dat je grubi pregled stepena izucenosti ove probblematike. U drugom delu izvestaja detaljnije su razmotrene neke statisticke i optimizacione metode koje bi se koristile u cilju automatizovanog fitovanja. Na osnovu toga data je procena mogucnosti realizacije odgovarajuuceg racunskog postupka. (author)

  12. The Etiquette of Accepting a Job Offer

    Science.gov (United States)

    Perlmutter, David D.

    2013-01-01

    The academic job market is overcrowded, but departments are hiring, and each year thousands of graduate students and other candidates will get phone calls offering them tenure-track positions. It is typically a moment of mutual giddiness. The department heads are excited at the prospect of a terrific new colleague; the job applicants now know that…

  13. 16 CFR 502.101 - Introductory offers.

    Science.gov (United States)

    2010-01-01

    ... Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENT OF GENERAL POLICY OR... FAIR PACKAGING AND LABELING ACT Retail Sale Price Representations § 502.101 Introductory offers. (a... retail sale at a price lower than the anticipated ordinary and customary retail sale price. (b) The...

  14. Scientific Library Offers New Training Options | Poster

    Science.gov (United States)

    The Scientific Library is expanding its current training opportunities by offering webinars, allowing employees to take advantage of trainings from the comfort of their own offices. Due to the nature of their work, some employees find it inconvenient to attend in-person training classes; others simply prefer to use their own computers. The Scientific Library has been

  15. Screening the possibility for removing cadmium and other heavy metals from wastewater sludge and bio-ashes by an electrodialytic method

    DEFF Research Database (Denmark)

    Ottosen, Lisbeth M.; Pedersen, Anne Juul; Hansen, Henrik K.

    2007-01-01

    in wastewater sludge and bio-ashes (straw and wood) using an electrodialytic method. The waste products were treated as stirred suspensions. During the remediation the suspension was acidified from water splitting at the anion exchange membrane and the acidification mobilized Cd that was removed...... with Cd, and the wood ash had a high initial pH (13.3). The mass of wastewater sludge and bio-ashes decreased during treatment but the concentration of other heavy metals (Pb, Ni, Cu and Zn) was not increased to exceed limiting values in remediated matrix.......Both wastewater sludge and fly ash from combustion of biomass (bio-ash) have traditionally been applied to agricultural land in Denmark. However, Cd concentrations often exceed limiting values. The present study is a preliminary investigation of the possibility for reducing the Cd concentration...

  16. Possible preparation of wood-plastic composites based on unsaturated polyester resins and styrene by radiation and chemical methods in combination

    International Nuclear Information System (INIS)

    Pesek, M.; Pultar, F.; Jarkovsky, J.; Andr, J.

    1983-01-01

    Using the radiation chemical method it is possible to prepare wood-plastic composites using doses of 1 to 2.5 kGy. The impregnation mixture in the wood gelatinates and subsequent curing using chemical initiators takes place without outflow of the mixture from the wood and without formation of incrustations. The basic components of the impregnation mixtures used were unsaturated polyester resins; styrene or methyl methacrylate was used as the thinner. The proven initiator of polymerization was 2,2'-azobisisobutyronitrile. The technology is described of wood impregnation and radiation or chemical curing. The effects were monitored of viscosity, temperature, radiation dose and the concentrations of the individual components of the impregnation mixtures and initiators of polymerization on the process of the preparation of wood-plastic composites. (M.D.)

  17. Technical classification and evaluation of possible methods for disposal of the wax for coating that leftover during preparation of the pineapple for export

    International Nuclear Information System (INIS)

    Carvajal Torres, Carlos

    2013-01-01

    The search and evaluation of possible methods of disposal are made for the waste of wax, generated during the coating of pineapple. Most suitable processes are characterized by means of tests in the laboratory, with the purpose of to assess the quality of treatment. The information of the possible methods of disposal to be employed has been collected through a literature review. The most suitable method was selected through of an evaluation, by application of a matrix of decision, which, a set of professionals related to this thematic were consulted. The coagulation-flocculation method is chosen according to the criteria considered and a series of evaluations was applied in the laboratory, to define the actual results that were obtained with the application of this treatment. The coagulant concentration and initial pH of the wax were determined statistically, and have had a significant effect on the volume of floc obtained. Also, within of the operating conditions established have been obtained that the optimum dose of flocculant has been 350 mg/L for Iron II sulphate and 400 mg/L for aluminum sulphate. A removal of the 88,7% is obtained for the chemical oxygen demand, 85,3% for the biochemical oxygen demand and 81,1% for fats and oils by employing aluminum sulphate. The yields for the removal of chemical oxygen demand has been of 80,3%, when is used the iron II sulphate, and for biochemical oxygen demand has been of the 80.5%, while the removal of fats and oils has been of 84,9%. A physicochemical process is proposed as a treatment system, and it consists of a roughing channel, a fast mixing zone (coagulation), a mixing zone slowly (flocculation) and a sedimentation. A sand filter of upward flow has complemented the system, followed by an activated carbon bed and horizontal wetland of subsurface flow. Besides, a sludge drying bed has disposed. The cost for construction of the treatment system has estimated of ₡12.700000. A physicochemical characterization of the

  18. Receipt of a pediatric liver offer as the first offer reduces waitlist mortality for adult women.

    Science.gov (United States)

    Ge, Jin; Gilroy, Richard; Lai, Jennifer C

    2018-03-31

    In liver transplantation, adults with small stature have a greater susceptibility to waitlist mortality. This may explain the persistent waitlist mortality disparity that exists for women. We hypothesized that women who receive early offers of pediatric donor livers have improved waitlist survival, and that preferentially offering these organs to women mitigates this sex-based disparity. We analyzed donor liver offers from 2010 to 2014. Adult candidates who received a first offer that ranked within the first three match run positions from the donors' perspective were classified based on gender and whether they received a pediatric versus adult offer. We used competing risks regression to associate first offer type and waitlist mortality. 8,101 waitlist candidates received a first offer that was ranked within the first three match run positions: 5.6% (293/5,202) men and 6.2% (179/2,899) women received a pediatric donor liver as their first offer. In multivariable analyses, compared to adult-first men, adult-first women (sHR1.33, 95%CI 1.17-1.51, p offer had a lower risk of waitlist mortality compared to those who receive adult offers. Our data provides a simple approach to mitigating the increased waitlist mortality experienced by women by incorporating donor and recipient size, as variables, into organ allocation. This article is protected by copyright. All rights reserved. © 2018 by the American Association for the Study of Liver Diseases.

  19. 7 CFR 1494.501 - Submission of offers to CCC.

    Science.gov (United States)

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS EXPORT BONUS PROGRAMS Export Enhancement... contract unit price, delivery terms (e.g., FOB, C&F, etc.); the nature of any arrangements or... CCC bonus; (B) The intention to submit an offer; or (C) The methods or factors used to calculate the...

  20. Classroom "Cupcake" Celebrations: Observations of Foods Offered and Consumed

    Science.gov (United States)

    Isoldi, Kathy K.; Dalton, Sharron; Rodriguez, Desiree P.; Nestle, Marion

    2012-01-01

    Objective: To describe food and beverage types offered and consumed during classroom celebrations at an elementary school in a low-income, urban community. In addition, to report student intake of fresh fruit provided alongside other party foods. Methods: Observations held during 4 classroom celebrations. Food and beverage items were measured and…

  1. Possible preparation of wood-plastic materials based on unsaturated polyester resins and methyl metacrylate, by radiation and chemical methods in combination

    International Nuclear Information System (INIS)

    Pesek, M.

    1982-01-01

    The preparation of wood-plastic combinations (WPC) using combined methods for curing intermediate products and final products is described. In the first step, impregnated wood was irradiated using doses of 1 to 10 kGy in the presence of chemical initiators of polymerization. Thereafter, curing of this partly cured impregnating mixture was accomplished in the wood at elevated temperatures with the aid of chemical initiators of polymerization. Impregnation mixtures based on unsaturated polyester resins and methyl methacrylate, and the wood species European Beech (Fagus silvatica) and Black Alder (Alnus glutinosa) were used. The results indicate that this method of preparing WPC allows substantially lower radiation doses to be used, i.e., doses in the range of 1 to 2.5 kGy. These doses gelatinate the impregnation mixture in the wood so that the subsequent curing by chemical polymerization initiators proceeds without the impregnation mixture flowing out of the wood, and without forming bosses and incrustations. Intermediate products and wood products needing no further finish may thus be prepared: in some cases regrinding or repolish is sufficient. The possibility of using impregnation mixtures based on various unsaturated polyester resins was investigated, and the influence on the curing process of temperature, polymerization initiator concentration, methyl methacrylate concentration, inhibitor concentration, and other factors affecting curing was evaluated. (author)

  2. Wind offering in energy and reserve markets

    DEFF Research Database (Denmark)

    Soares, Tiago; Pinson, Pierre; Morais, Hugo

    2016-01-01

    The increasing penetration of wind generation in power systems to fulfil the ambitious European targets will make wind power producers to play an even more important role in the future power system. Wind power producers are being incentivized to participate in reserve markets to increase...... their revenue, since currently wind turbine/farm technologies allow them to provide ancillary services. Thus, wind power producers are to develop offering strategies for participation in both energy and reserve markets, accounting for market rules, while ensuring optimal revenue. We consider a proportional...... offering strategy to optimally decide upon participation in both markets by maximizing expected revenue from day-ahead decisions while accounting for estimated regulation costs for failing to provide the services. An evaluation of considering the same proportional splitting of energy and reserve in both...

  3. FOREIGN LANGUAGE PROGRAMS OFFERED IN TURKISH UNIVERSITIES

    Directory of Open Access Journals (Sweden)

    Bengül CETINTAS

    2016-10-01

    Full Text Available n this study, the departments of philology and teaching, which take place in higher education programs in Turkey and give education in foreign language, have been examined. 23 different languages are offered to philology students who wants to attend to faculty of literature. Students can prefer classical languages besides modern languages. However, English, German, French, Arabic and Japanese are offered to the students of teaching department. To teach another foreign language, pedagogical formation is also required.This study focuses on the departments of German Language Teaching and German Language and Literature. From this point, the place and the importance of other philology and foreign language teaching departments in Turkish higher education have been examined.

  4. Strategies and tactics in structuring equity offerings

    International Nuclear Information System (INIS)

    Emes, A. F.

    1998-01-01

    Volatile changes in the oil and gas sector investment climate within the last few months were reviewed in an effort to illustrate that despite the sharp downturn in the attractiveness of gas and oil sector investments, certain financing transactions are still being completed, and 'deals' are still available, provided that they are made attractive to investors. Investors may be more selective, may be looking more carefully at the issuing company's track record and management, but they are still there for the right deal. Flow-through offerings, share-for-share, or share-for-property acquisitions, joint ventures, sale of assets as alternative to equity, the junior capital pool as an alternative to initial public offering, the reverse take over, use of the royalty tax market, project financing, convertible debentures, and the use of warrants were explored as options available to issuers to attract investors even during difficult times

  5. 75 FR 32840 - Securities Offering Disclosures

    Science.gov (United States)

    2010-06-09

    ... make an informed investment decision regarding a possible purchase or sale of a savings association's... control number. As part of the approval process, we invite comments on the following information...

  6. How much is our fairness worth? The effect of raising stakes on offers by Proposers and minimum acceptable offers in Dictator and Ultimatum Games.

    Directory of Open Access Journals (Sweden)

    Julie Novakova

    Full Text Available BACKGROUND: The aim of this study was to determine whether people respond differently to low and high stakes in Dictator and Ultimatum Games. We assumed that if we raised the stakes high enough, we would observe more self-orientated behavior because fairness would become too costly, in spite of a possible risk of a higher punishment. METHODS: A questionnaire was completed by a sample of 524 university students of biology. A mixed linear model was used to test the relation between the amount at stake (CZK 20, 200, 2,000, 20,000 and 200,000, i.e., approximately $1-$10,000 and the shares, as well as the subjects' gender and the design of the study (single vs. multiple games for different amounts. RESULTS: We have discovered a significant relationship between the amount at stake and the minimum acceptable offer in the Ultimatum Game and the proposed shares in both Ultimatum and Dictator Games (p = 0.001, p<0.001, p = 0.0034. The difference between playing a single game or more games with several amounts at stake did not influence the relation between the stakes and the offered and minimum acceptable shares. Women proved significantly more generous than men in their offers in the Dictator Game (p = 0.007. CONCLUSION: Our results suggest that people's behavior in the Dictator and Ultimatum Games depends on the amount at stake. The players tended to lower their relative proposed shares, as well as their relative minimum acceptable offers. We propose that the Responders' sense of equity and fair play depends on the stakes because of the costs of maintaining fairness. However, our results also suggest that the price of fairness is very high and that it is very difficult, probably even impossible, to buy the transition of Homo sociologicus into Homo economicus.

  7. Turnkey offering a claimed sector 'first'.

    Science.gov (United States)

    Law, Oliver

    2011-01-01

    Manufacturer and supplier of LED theatre lights, HD camera systems, video integration technologies, and ceiling support units, Trumpf Medical Systems UK, and "logistical services" company Canute International Medical Services (CIMS), one of whose specialities is providing mobile medical units for diagnostic imaging, have entered into a partnership that will see the two companies offer fully fitted out modular operating theatres and other medical/clinical buildings incorporating the latest technology and equipment, on a fully project-managed, "turnkey" basis. Oliver Law, Trumpf Medical Systems UK managing director, explains the background, and the new service's anticipated customer benefits.

  8. Albania, offshore subscribed, offering EOR opportunities

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    This paper reports that Albania is starting a campaign to offer field development/enhanced recovery projects to foreign companies. The fields chosen for EOR projects and their producing lithologies are: Patos-Marinza, sandstone. Kucova-Arrza, sandstone. Gorisht-Kocul, limestone. Ballsh-Hekal, limestone. Cakran-Mollaj, limestone. Visoka, limestone. Delvina, limestone. Field locations mostly lie along Albania's Adriatic Sea coast. Oil production began in Albania in 1929, peaked at about 60,000 b/d in 1975 and has steadily fallen

  9. Screening the possibility for removing cadmium and other heavy metals from wastewater sludge and bio-ashes by an electrodialytic method

    International Nuclear Information System (INIS)

    Ottosen, Lisbeth M.; Pedersen, Anne J.; Hansen, Henrik K.; Ribeiro, Alexandra B.

    2007-01-01

    Both wastewater sludge and fly ash from combustion of biomass (bio-ash) have traditionally been applied to agricultural land in Denmark. However, Cd concentrations often exceed limiting values. The present study is a preliminary investigation of the possibility for reducing the Cd concentration in wastewater sludge and bio-ashes (straw and wood) using an electrodialytic method. The waste products were treated as stirred suspensions. During the remediation the suspension was acidified from water splitting at the anion exchange membrane and the acidification mobilized Cd that was removed to the electrode compartments. Even though the matrices were very different the remediation was successful in all cases. After treatment the Cd concentration in the ashes allowed for spreading at agricultural land and the limiting concentration of 0.8 mg Cd/kg for the wastewater sludge was almost reached (0.84 and 0.88 mg Cd/kg). The main differences of the waste products influencing the remediation process were: the sludges had a high content of organic particles that were mobilized by electrophoresis and fouled the anion exchange membrane; the straw-ash contained a lot of chloride, which formed anionic complexes with Cd, and the wood ash had a high initial pH (13.3). The mass of wastewater sludge and bio-ashes decreased during treatment but the concentration of other heavy metals (Pb, Ni, Cu and Zn) was not increased to exceed limiting values in remediated matrix

  10. Revising shortwave and longwave radiation archives in view of possible revisions of the WSG and WISG reference scales: methods and implications

    Science.gov (United States)

    Nyeki, Stephan; Wacker, Stefan; Gröbner, Julian; Finsterle, Wolfgang; Wild, Martin

    2017-08-01

    A large number of radiometers are traceable to the World Standard Group (WSG) for shortwave radiation and the interim World Infrared Standard Group (WISG) for longwave radiation, hosted by the Physikalisch-Meteorologisches Observatorium Davos/World Radiation Centre (PMOD/WRC, Davos, Switzerland). The WSG and WISG have recently been found to over- and underestimate radiation values, respectively (Fehlmann et al., 2012; Gröbner et al., 2014), although research is still ongoing. In view of a possible revision of the reference scales of both standard groups, this study discusses the methods involved and the implications on existing archives of radiation time series, such as the Baseline Surface Radiation Network (BSRN). Based on PMOD/WRC calibration archives and BSRN data archives, the downward longwave radiation (DLR) time series over the 2006-2015 period were analysed at four stations (polar and mid-latitude locations). DLR was found to increase by up to 3.5 and 5.4 W m-2 for all-sky and clear-sky conditions, respectively, after applying a WISG reference scale correction and a minor correction for the dependence of pyrgeometer sensitivity on atmospheric integrated water vapour content. Similar increases in DLR may be expected at other BSRN stations. Based on our analysis, a number of recommendations are made for future studies.

  11. How possible is the development of an operational psychometric method to assess the presence of the 5-HTTLPR s allele? Equivocal preliminary findings

    Directory of Open Access Journals (Sweden)

    Laszik Andras

    2010-05-01

    Full Text Available Abstract Objective The s allele of the 5-hydroxytryptamine transporter-linked promoter region (5-HTTLPR polymorphism of the serotonin transporter gene has been found to be associated with neuroticism-related traits, affective temperaments and response to selective serotonin reuptake inhibitor (SSRI treatment. The aim of the current study was to develop a psychometric tool that could at least partially substitute for laboratory testing and could predict the presence of the s allele. Methods The study included 138 women of Caucasian origin, mean 32.20 ± 1.02 years old. All subjects completed the Hungarian standardised version of the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire (TEMPS-A instrument and were genotyped for 5-HTTLPR using PCR. The statistical analysis included the calculation of the Index of Discrimination (D, Discriminant Function Analysis, creation of scales on the basis of the above and then item analysis and calculation of sensitivity and specificity. Results Four indices were eventually developed, but their psychometric properties were relatively poor and their joint application did not improve the outcome. Conclusions We could not create a scale that predicts the 5-HTTLPR genotype with sufficient sensitivity and specificity, therefore we could not substitute a psychometric scale for laboratory genetic testing in predicting genotype, and also possibly affective disorder characterisation and treatment.

  12. Characteristics of a Bulk High-Critical Temperature Superconductor Fabricated by the Shock Compaction Method: Possible Use as a Highly Sensitive Magnetic Sensor

    International Nuclear Information System (INIS)

    Fujita, H; Maeji, Y; Yamagata, K; Itoh, M; Kezuka, H; Kikuchi, M; Atou, T; Kawasaki, M; Fukuoka, K

    2006-01-01

    A magnetic sensor, constructed of bulk Bi-Pb-Sr-Ca-Cu-O (BPSCCO), was fabricated by use of the shock compaction method, employing a propellant gun-system, and then sintered under through use of an electronic furnace. The specimen as a magnetic sensor was maintained in the superconducting state at 77.4 K, under a current density J of approximately 40 A/cm 2 in the absence of an excitation magnetic field B ex . The superconducting state was then broken and the specimen exposed to a B ex value of 40x10 -4 T. That is, the resistance R meas of the specimen occurred when exposed to 40x10 -4 T under a constant J of 40 A/cm 2 . The magnetic sensitivity S of the specimen was approximately 13 %/(10 -4 T) over the range of measurement of the magnetic field B meas from 0 to ±5x10 -4 T, under a constant 40x10 -4 T for the value of B ex , being approximately 13 times greater than that of a giant magnetoresistance (GMR) sensor. It was, consequently, determined that it was possible to apply the bulk BPSCCO specimen as a highly sensitive magnetic sensor

  13. Characteristics of a Bulk High-Critical Temperature Superconductor Fabricated by the Shock Compaction Method: Possible Use as a Highly Sensitive Magnetic Sensor

    Energy Technology Data Exchange (ETDEWEB)

    Fujita, H [Interdisci. Grad. School of Sci. and Engi., Grad. School of Kinki University, Higashi-Osaka, Osaka 577-8502 (Japan); Maeji, Y [Interdisci. Grad. School of Sci. and Engi., Grad. School of Kinki University, Higashi-Osaka, Osaka 577-8502 (Japan); Yamagata, K [Relia. Eval. Technol. Center, Nitto Denko Corp., Onomichi, Hiroshima 722-0212 (Japan); Itoh, M [Interdisci. Grad. School of Sci. and Engi., Grad. School of Kinki University, Higashi-Osaka, Osaka 577-8502 (Japan); Kezuka, H [Faculty of Bionics, Tokyo University of Technol., Hachioji, Tokyo 192-0982 (Japan); Kikuchi, M [Kansen Fukushi Research Center, Tohoku Fukushi University Sendai, Miyagi 989-3201 (Japan); Atou, T [Insti. for Mate. Research, Tohoku University Sendai, Miyagi 980-8577 (Japan); Kawasaki, M [Insti. for Mate. Research, Tohoku University Sendai, Miyagi 980-8577 (Japan); Fukuoka, K [Insti. for Mate. Research, Tohoku University Sendai, Miyagi 980-8577 (Japan)

    2006-06-01

    A magnetic sensor, constructed of bulk Bi-Pb-Sr-Ca-Cu-O (BPSCCO), was fabricated by use of the shock compaction method, employing a propellant gun-system, and then sintered under through use of an electronic furnace. The specimen as a magnetic sensor was maintained in the superconducting state at 77.4 K, under a current density J of approximately 40 A/cm{sup 2} in the absence of an excitation magnetic field B{sub ex}. The superconducting state was then broken and the specimen exposed to a B{sub ex} value of 40x10{sup -4} T. That is, the resistance R{sub meas} of the specimen occurred when exposed to 40x10{sup -4} T under a constant J of 40 A/cm{sup 2}. The magnetic sensitivity S of the specimen was approximately 13 %/(10{sup -4} T) over the range of measurement of the magnetic field B{sub meas} from 0 to {+-}5x10{sup -4} T, under a constant 40x10{sup -4} T for the value of B{sub ex}, being approximately 13 times greater than that of a giant magnetoresistance (GMR) sensor. It was, consequently, determined that it was possible to apply the bulk BPSCCO specimen as a highly sensitive magnetic sensor.

  14. Offer - La Comédie theatre

    CERN Multimedia

    Staff Association

    2017-01-01

    The “La Comédie” theatre unveiled its programme for the season 2017–2018. We are delighted to share this brand new, rich and varied programme with you. The “La Comédie” theatre has various discounts for our members Buy 2 subscriptions for the price of 1 : 2 cards “Libertà” for CHF 240.- instead of CHF 480.- Cruise freely through the season with an 8-entry card valid for the shows of your choice. These cards are transferable and can be shared with one or more accompanying persons. 2 cards “Piccolo” for CHF 120 instead of CHF 240.- This card lets you discover 4 shows which are suitable for all audiences (offers valid while stock lasts) Benefit from a reduction of 20 % on a full price ticket during all the season: from CHF 40.- to CHF 24.- ticket instead of CHF 50.- to CHF 30.- depending on the show (Also valid for one accompanying person). Interested in one of these offers? Create an ac...

  15. Wind offering in energy and reserve markets

    Science.gov (United States)

    Soares, T.; Pinson, P.; Morais, H.

    2016-09-01

    The increasing penetration of wind generation in power systems to fulfil the ambitious European targets will make wind power producers to play an even more important role in the future power system. Wind power producers are being incentivized to participate in reserve markets to increase their revenue, since currently wind turbine/farm technologies allow them to provide ancillary services. Thus, wind power producers are to develop offering strategies for participation in both energy and reserve markets, accounting for market rules, while ensuring optimal revenue. We consider a proportional offering strategy to optimally decide upon participation in both markets by maximizing expected revenue from day-ahead decisions while accounting for estimated regulation costs for failing to provide the services. An evaluation of considering the same proportional splitting of energy and reserve in both day- ahead and balancing market is performed. A set of numerical examples illustrate the behavior of such strategy. An important conclusion is that the optimal split of the available wind power between energy and reserve strongly depends upon prices and penalties on both market trading floors.

  16. What Do Ecological Paradigms Offer to Conservation?

    International Nuclear Information System (INIS)

    Ale, S.B.; Howe, H.F.; Ale, S.B.; Howe, H.F.

    2010-01-01

    Ecological theory provides applications to biodiversity management but often falls short of expectations. One possibility is that heuristic theories of a young science are too immature. Logistic growth predicts a carrying capacity, but fisheries managed with the Lotka-Volterra paradigm continue to collapse. A second issue is that general predictions may not be useful. The theory of island biogeography predicts species richness but does not predict community composition. A third possibility is that the theory itself may not have much to do with nature, or that empirical parameterization is too difficult to know. The meta population paradigm is relevant to conservation, but meta populations might not be common in nature. For instance, empirical parameterization within the meta population paradigm is usually infeasible. A challenge is to determine why ecology fails to match needs of managers sometimes but helps at other. Managers may expect too much of paradigmatic blueprints, while ecologists believe them too much. Those who implement biodiversity conservation plans need simple, pragmatic guidelines based on science. Is this possible. What is possible An eclectic review of theory and practice demonstrate the power and weaknesses of the ideas that guide conservation and attempt to identify reasons for prevailing disappointment.

  17. Why do patients decline participation in offered pulmonary rehabilitation?

    DEFF Research Database (Denmark)

    Mathar, Helle; Fastholm, Pernille; Lange, Peter

    2017-01-01

    of chronic obstructive pulmonary disease and among stable patients attending an outpatient clinic. Participants: Patients who decline participation in offered pulmonary rehabilitation, who speak Danish, who are able to give informed consent and to participate in a 1-hour interview. Method: The research...... question was answered through interviews with 19 patients. Data Analysis: The interviews were recorded and transcribed verbatim. The transcripts were analyzed using inductive content analysis. The transcripts were condensed; categories were developed providing different types of explanations for declining...

  18. Does offering prenatal screening influence pregnant women's attitudes regarding prenatal testing?

    NARCIS (Netherlands)

    Kleinveld, J.H.; van den Berg, M.; van Eijk, J.T.; van Vugt, J.M.G.; van der Wal, G.; Timmermans, D.R.M.

    2008-01-01

    Objectives: This study aims to find out whether offering prenatal screening for Down syndrome and neural tube defects influences pregnant women's attitudes toward having a screening test. Methods: Women were randomised into a group that was offered prenatal screening and a group that was not offered

  19. environmental education programmes offered by delta

    African Journals Online (AJOL)

    ENVIRONMENTAL CENTRE: SOME RESEARCH FINDINGS ... approach so as to achieve education for sustainable .... Qualitative research tbat emphasises ..... Quantitative Approaches. Sage ... Applied Social Research Methods Series 5.

  20. Tourist offer and tourist fair: Marketing approach

    Directory of Open Access Journals (Sweden)

    Berber Ivana

    2007-01-01

    Full Text Available Nowadays, the main aim of tourism system, which is an important part of economy, is a preservation and an improvement of itself supply, as well as connection with demand. As there are many of promotion activities, it requests their adequate observation. Fair activities, as one of the possible ways of promotion, have its own advantages, especially in total tourism product promotion. This paper is focused on importance and role of tourism fairs in continuously achievement of tourism system goals.

  1. Solar panels offer array of hope.

    Science.gov (United States)

    Baillie, Jonathan

    2009-01-01

    The installation of what is believed to be the largest array of solar thermal panels currently in use at a UK NHS hospital has taken place at an ideal time for the facility in question, Harlow's Princess Alexandra Hospital, with the hospital's gas bill alone having risen by 153% over the past nine months thanks to soaring energy prices, and the estates department keen to mitigate the effects in any way possible. Jonathan Baillie reports.

  2. Outdoor Education Course - The New Product of a Company Offer

    OpenAIRE

    Beránek, Jiří

    2007-01-01

    and Key Words Title: Outdoor Education Course- The New Product of a Company Offer Aim: Analysis and evaluation of needs and attitudes of the present company clients of Firma na zážitky, s.r.o. company in the outdoor education field to frame a pilot project of an outdoor course programme. Method: Method of questionnare was used to analyse and evaluate needs and attitudes ofthe company clients. Results: A project of outdoor course programme was created according to results of realized research....

  3. CEE region offers ample value proposition

    Energy Technology Data Exchange (ETDEWEB)

    Dobrova, Helena; Gawenda, Piotr [IHS, Geneva (Switzerland)

    2008-12-15

    The Central-Eastern Europe region (CEE) continues to evolve and offer ample value propositions to various types of operators. This area experiences a surge of exploration and production (E and P) interest over the past years. The bulk of the present-day production in the CEE countries is derived from mature oil and gas fields situated in prolific hydrocarbon provinces known since the mid-XIX century (e.g., the Carpathians in Poland and Romania). Yet, these areas still remain the major exploration targets to this day. The authors of the contribution under consideration summarize the E and P activities in the CEE countries during the past 12 to 18 months. This summary shows a fairly heterogeneous petroleum-related exploration picture: some countries have yet to launch their first E and P operations, others maintain a somewhat limited level of activities, while a few states, namely Bulgaria, Hungary, Poland and Romania, show a very busy contractual and operational shedule. The effords are yielding astounding results in some countries, delivered principally by small-size to medium-size independent explorers, as well as former state entities and a few remaining NOCs.

  4. Ottawa offers funds for particle accelerator

    International Nuclear Information System (INIS)

    1991-01-01

    The federal government has offered to contribute at least $236 million toward the controversial KAON particle accelerator facility in Vancouver. Justice Minister Kim Campbell says that no deal on the project has been signed, but negotiations with British Columbia are going well. She said Ottawa is prepared to contribute a third of the operating costs. The facility is intended to investigate the basic structure of matter by smashing atoms into their tiniest components known as quarks. It's estimated that operating costs will be in the range of $90 million a year. Campbell said the United States is willing to contribute $100 million toward the project, but did not know what this would be for. Debate about the KAON facility within the scientific community has been raging for years. Many scientists fear KAON would draw money away from other areas of research, which already face chronic financial problems. Campbell insisted that KAON would not distort overall research priorities, but made no firm commitments about increases for other areas of science. She said money for KAON, assuming the project does get final approval, will not be delivered before the 1994 fiscal year and won't affect efforts to reduce the federal deficit

  5. Possibilities and limitations of analogue methods for studying the dynamics of nuclear power stations; Possibilites et limitations du calcul analogique pour les etudes dynamiques de centrales nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Caillet, C; Deat, M [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    1. Introduction: the present paper is devoted to analog simulation of problems related to nuclear reactors other than the simulation of the kinetic equations which is well known. 2. Thermodynamic problems: various problems relative to temperature evolution in a reactor, in a pipe, in an exchanger, in a turbine, are studied, and simulation techniques used by earlier authors are critically reviewed. 3. Pipe simulators: it is shown that this problem can be solved by the use of specialized simulators which will be described and analysed. 4. Rotating machine simulators: the particular aspect of rotating machine calculations introducing frequent use of diagrams is emphasized. A simulator requiring both digital and analogue methods is described. 5. The study of a nuclear power station: as an example it is proposed to discuss problems a rising in connection with the preceding elements (a, b, c, d) when simulating the behaviour of large nuclear plants. The part played by ordinary computing elements for the simulation of the different servomechanism transfer functions is considered and process of regulation is outlined. 6. Conclusion: the necessity of the use of high quality simulators and computers is underlined and the accuracy of the solutions is discussed. (author)Fren. [French] 1. Cinetique des reacteurs: la simulation des equations cinetiques d'un reacteur nucleaire ne pose desormais plus de probleme. II est donc possible de faire le point des differentes applications de la technique analogique dans ce domaine. 2. Les problemes thermodynamiques: on discute les differents problemes poses par l'evolution des temperatures dans un reacteur, dans une tuyauterie, dans un echangeur, dans une turbine, et on passe en revue les techniques de simulation proposees jusqu'a ce jour. 3s simulateurs de tuyauteries: on montre comment les differents problemes poses ci-dessus peuvent etre resolus, pour une classe tres vaste de reacteurs par l'emploi de simulateurs speciaux que l

  6. Offering Strategy of a Flexibility Aggregator in a Balancing Market Using Asymmetric Block Offers

    DEFF Research Database (Denmark)

    Bobo, Lucien Ali; Delikaraoglou, Stefanos; Vespermann, Niklas

    2018-01-01

    scenarios are used to find optimal load-shifting offers under uncertainty. The problem is formulated as a stochastic mixed-integer linear program and can be solved with reasonable computational time. This work is taking place in the framework of the real-life demonstration project EcoGrid 2.0, which......In order to enable large-scale penetration of renewables with variable generation, new sources of flexibility have to be exploited in the power systems. Allowing asymmetric block offers (including response and rebound blocks) in balancing markets can facilitate the participation of flexibility...... aggregators and unlock load-shifting flexibility from, e.g., thermostatic loads. In this paper, we formulate an optimal offering strategy for a risk-averse flexibility aggregator participating in such a market. Using a price-taker approach, load flexibility characteristics and balancing market price forecast...

  7. On feelings as a heuristic for making offers in ultimatum negotiations.

    Science.gov (United States)

    Stephen, Andrew T; Pham, Michel Tuan

    2008-10-01

    This research examined how reliance on emotional feelings as a heuristic influences how offers are made. Results from three experiments using the ultimatum game show that, compared with proposers who do not rely on their feelings, proposers who rely on their feelings make less generous offers in the standard ultimatum game, more generous offers in a variant of the game allowing responders to make counteroffers, and less generous offers in a dictator game in which no responses are allowed. Reliance on feelings triggers a more literal form of play, whereby proposers focus more on how they feel toward the content of the offers than on how they feel toward the possible outcomes of those offers, as if the offers were the final outcomes. Proposers who rely on their feelings also tend to focus on gist-based construals of the negotiation that capture only the essential aspects of the situation.

  8. 48 CFR 225.7703-3 - Evaluating offers.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Evaluating offers. 225... Iraq or Afghanistan 225.7703-3 Evaluating offers. (a) Evaluate offers submitted in response to... Afghanistan, as follows: (1) If the low offer is an offer of a product or service from Iraq or Afghanistan...

  9. Marketing Digital Offerings Is Different: Strategies for Teaching about Digital Offerings in the Marketing Classroom

    Science.gov (United States)

    Roberts, Scott D.; Micken, Kathleen S.

    2015-01-01

    Digital offerings represent different challenges for marketers than do traditional goods and services. After reviewing the literature, the authors suggest ways that the marketing of digital goods and services might be better presented to and better understood by students. The well-known four challenges of services marketing model (e.g.,…

  10. Marketing in Dutch mainline congregations. The importance of what religious organizations offer and how they offer

    NARCIS (Netherlands)

    Sengers, E.

    2010-01-01

    In rational choice theory, the central explanatory term for the vitality of religious organizations is 'cost'. The higher the cost, the more successful the organization is supposed to be. However, as cost and reward are complementary, research should also pay attention to the rewards offered by

  11. 17 CFR 230.802 - Exemption for offerings in connection with an exchange offer or business combination for the...

    Science.gov (United States)

    2010-04-01

    ... connection with an exchange offer or business combination for the securities of foreign private issuers. 230... Offers and Business Combinations § 230.802 Exemption for offerings in connection with an exchange offer or business combination for the securities of foreign private issuers. Offers and sales in any...

  12. The Effect of Subsidies on the Offer of Sea Transport

    Directory of Open Access Journals (Sweden)

    Drago Pupavac

    2017-01-01

    Full Text Available The main goal of this academic discussion is to study the effect of subsidies on the offer of sea transport. Research results are based on the method of microeconomic analysis. The knowledge obtained through this academic discussion may prove to be of assistance to managers in the area of sea transport in deliberating on more efficient and market-oriented business models. The results of this work reveal that subsidies in sea transport make sense if they contribute to the improvement of the quality of transport or are of help to those for whom they are intended.

  13. USE OF POWERPOINT POSSIBILITIES IN IMPLEMENTATION OF PROJECT METHOD INTO THE LEARNING PROCESS WHILE STUDYING CHEMISTRY IN PROFESSION-ORIENTED SCHOOL

    Directory of Open Access Journals (Sweden)

    Maria D. Tukalo

    2011-02-01

    Full Text Available The article reveals the importance of the opportunities and prospects for the introduction of PowerPoint project method in chemistry lessons in profession-oriented school, which is a prerequisite in the search for innovative, effective and optimal computer-oriented teaching methods and forms for the establishment of conditions for the development of creative potential of students based on competences through the organization individual, creative and research activities in the educational system of modern technology. It enables to design the educational process, use of generalized methods of training for providing training and guaranteed results.

  14. 33 CFR 5.37 - Offer of facilities.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Offer of facilities. 5.37 Section... GUARD AUXILIARY § 5.37 Offer of facilities. Any member of the Auxiliary desiring to place a vessel... in such communication which facility is offered. Except in emergencies, an offer to the Coast Guard...

  15. 46 CFR 201.144 - Offer of proof.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Offer of proof. 201.144 Section 201.144 Shipping... PROCEDURE Evidence (Rule 14) § 201.144 Offer of proof. An offer of proof made in connection with an... accompany the record as the offer of proof. ...

  16. 45 CFR 81.85 - Offer of proof.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Offer of proof. 81.85 Section 81.85 Public Welfare... 80 OF THIS TITLE Hearing Procedures § 81.85 Offer of proof. An offer of proof made in connection with... identification and shall accompany the record as the offer of proof. ...

  17. 49 CFR 604.43 - Offer of proof.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Offer of proof. 604.43 Section 604.43..., DEPARTMENT OF TRANSPORTATION CHARTER SERVICE Hearings. § 604.43 Offer of proof. A party whose evidence has... respond to the offer of proof, may offer the evidence on the record when filing an appeal. ...

  18. 38 CFR 18b.64 - Offer of proof.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Offer of proof. 18b.64... Procedures § 18b.64 Offer of proof. An offer of proof made in connection with an objection taken to any... record as the offer of proof. ...

  19. 48 CFR 570.203-3 - Soliciting offers.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Soliciting offers. 570.203... 570.203-3 Soliciting offers. (a) Solicit offers by providing each prospective offeror a proposed short..., evaluation procedures and submissions of offers. ...

  20. 12 CFR 563g.4 - Non-public offering.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Non-public offering. 563g.4 Section 563g.4 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY SECURITIES OFFERINGS § 563g.4 Non-public offering. Offers and sales of securities by an issuer that satisfy the conditions of...

  1. 12 CFR 563g.8 - Use of the offering circular.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Use of the offering circular. 563g.8 Section 563g.8 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY SECURITIES OFFERINGS § 563g.8 Use of the offering circular. (a) An offering circular or amendment declared effective by the...

  2. 12 CFR 563g.2 - Offering circular requirement.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Offering circular requirement. 563g.2 Section 563g.2 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY SECURITIES OFFERINGS § 563g.2 Offering circular requirement. (a) General. No savings association shall offer or sell, directly...

  3. ISMB 2016 offers outstanding science, networking, and celebration.

    Science.gov (United States)

    Fogg, Christiana

    2016-01-01

    The annual international conference on Intelligent Systems for Molecular Biology (ISMB) is the major meeting of the International Society for Computational Biology (ISCB). Over the past 23 years the ISMB conference has grown to become the world's largest bioinformatics/computational biology conference. ISMB 2016 will be the year's most important computational biology event globally. The conferences provide a multidisciplinary forum for disseminating the latest developments in bioinformatics/computational biology. ISMB brings together scientists from computer science, molecular biology, mathematics, statistics and related fields. Its principal focus is on the development and application of advanced computational methods for biological problems. ISMB 2016 offers the strongest scientific program and the broadest scope of any international bioinformatics/computational biology conference. Building on past successes, the conference is designed to cater to variety of disciplines within the bioinformatics/computational biology community.  ISMB 2016 takes place July 8 - 12 at the Swan and Dolphin Hotel in Orlando, Florida, United States. For two days preceding the conference, additional opportunities including Satellite Meetings, Student Council Symposium, and a selection of Special Interest Group Meetings and Applied Knowledge Exchange Sessions (AKES) are all offered to enable registered participants to learn more on the latest methods and tools within specialty research areas.

  4. Preliminary investigation of the possibility for implementation of modified pharmacopoeial HPLC methods for quality control of metronidazole and ciprofloxacin in medicinal products used in veterinary medicine

    Directory of Open Access Journals (Sweden)

    Marjan Piponski

    2015-03-01

    Full Text Available Quality control of veterinary medicine products containing two different frequently used antibiotics metronidazole and ciprofloxacin hydrochloride, was considered and performed, using modified pharmacopoeial HPLC methods. Three different HPLC systems were used: Varian ProStar, Perkin Elmer Series and UPLC Shimadzu Prominence XR. The chromatographic columns used were LiChropher RP Select B 75 mm x 4 mm with 5 μm particles and Discovery C18 100 mm x 4,6 mm with 5 μm particles. Chromatographic methods used for both analytes were compendial, with minor modifications made for experimental purposes. Minor modifications of the pharmacopoeia prescribed chromatographic conditions, in both cases, led to better chromatographic parameters, good resolution and shorter analysis times. Optimized methods can be used for: determination of metronidazole in gel formulation, for its simultaneous quantification with preservatives present in the formulation and even for identification and quantification of its specified impurity, 2-methyl-5-nitroimidazole; determination of ciprofloxacin hydrochloride in film coated tablets and eye drops and identification and quantification of its specified impurities. These slightly modified and optimized pharmacopoeial methods for quality control of metronidazole and ciprofloxacin dosage forms used in veterinary medicine can be successfully applied in laboratories for quality control of veterinary medicines.

  5. Is the Evaluation of the Students' Values Possible? An Integrated Approach to Determining the Weights of Students' Personal Goals Using Multiple-Criteria Methods

    Science.gov (United States)

    Dadelo, Stanislav; Turskis, Zenonas; Zavadskas, Edmundas Kazimieras; Kacerauskas, Tomas; Dadeliene, Ruta

    2016-01-01

    To maximize the effectiveness of a decision, it is necessary to support decision-making with integrated methods. It can be assumed that subjective evaluation (considering only absolute values) is only remotely connected with the evaluation of real processes. Therefore, relying solely on these values in process management decision-making would be a…

  6. Technique of experimental definition of optical thickness of the plasma channel by the method of lightening and possibilities of its application for pulsing discharge in water

    International Nuclear Information System (INIS)

    Fedorovich, O.A.

    2008-01-01

    Results of development and application of a technique of experimental definition of optical thickness τ of the plasma channel in water by the method of lightening are given. Plasma of the discharge in water managed to be lighten through on a stage of relaxation and the logarithm of coefficient of passage of radiation from an extraneous radiation source have been determined. The basic contribution to size of optical thickness gives absorption of radiation, instead of dispersion. But this value is not real optical thickness. Calculation of atoms N a concentration in the channel on values τ, received by the lightening through method, at 4 - 15 times is overestimated in comparison to the values of concentration, received by other independent method. Results of direct measurements of τ by illumination of the plasma channel by reference source EhV-45 are overestimated because of features of passage of appearing through radiation through the channel of the discharge in water of the cylindrical form as it represents a disseminating lens. The reasons of this distinguish of the received by lightening through method values of τ in cylindrical plasma channel in liquids are given. The technique of definition of time of a delay of the beginning of expansion of the channel concerning the moment of submission of a voltage on a digit interval is developed

  7. Influence of the reclamation method of spent moulding sands on the possibility of creating favourable conditions for gases flow in a mould

    Directory of Open Access Journals (Sweden)

    Łucarz M.

    2017-03-01

    Full Text Available The results of investigations concerning the influence of the applied sand matrix (fresh sand, reclaim on the properties of moulding sands used for production of large dimensional castings (ingot moulds, ladles, are presented in the hereby paper. The performed investigations were aimed at determining the influence of various reclamation methods of spent moulding sands on the quality of the obtained reclaimed material. Moulding sands were prepared on the fresh quartz matrix as well as on sand matrices obtained after various reclamation methods. The selected moulding sand parameters were tested (strength, permeability, grindability, ignition losses, pH reactions. It can be stated, on the basis of the performed investigations, that the kind of the applied moulding sand matrix is of an essential meaning from the point of view of creating conditions minimising formation of large amounts of gases and their directional migration in a casting mould.

  8. Radiotracer methods for effluent transport studies. A possibility of application for coastal sea waters and underground waters in near-sea region; Metody znacznikowe w badaniach transportu zanieczyszczen

    Energy Technology Data Exchange (ETDEWEB)

    Strzelecki, M.; Owczarczyk, A. [Institute of Nuclear Chemistry and Technology, Warsaw (Poland)

    1994-12-31

    The surface and ground waters are a final receivers of industrial, agriculture and municipal effluents. The observation of their transport and deposition in environmental waters can be the expansion measure for ecological hazard estimation. The tracer methods are one of more convenient tools for studying the number of problems connecting with environmental waters protection. Among them the topics are described in the paper: transport of effluents in big water reservoirs and rivers as well as the effluent transport in aquifers. 9 refs.

  9. The possible ways for soil complex purification from radionuclides in conditions of large-scale contamination and effectiveness of used methods

    International Nuclear Information System (INIS)

    Bondar, Y.; Konoplia, E.

    1999-01-01

    There has been a considerable aggregate effect of natural factors on soils contaminated with radioactive pollution by autopurification. Such factors such as natural decay, vertical migration of nuclides over the soil profile, as well as cyclic carrying of nuclides from the soil by vegetation, have been analyzed. The contaminated Belarus Polessie soils, as the result of the Chernobyl Catastrophe, have shown that during the past 13 years, a 1.5-1.7 fold decrease of long living radionuclides has taken place in the rooting layer. The qualitative characteristics of the soil purification process by phytocoenosis have been established, and the effectiveness and limitations of this method have been demonstrated. The effect of microbiological soil processes on the radionuclides mobility have been studied and the issues of the migration process intensification by means of optimal nutrient media have been considered. Hydroseparation of highly dispersed soil particles with simultaneous consideration of the soil organic substance contents allows attainment of a purification coefficient of 1.5-2. Further increase of C pur leads to irreversible humus substance loss and depriving the soil of its fertility, in addition the quantity of solid wastes dramatically increases that should be localized. A soil cut has been carried out on an experimental plot. It has been shown that the effectiveness of this method is high in comparison with other appropriate methods. However, with time, the purification rate decreases due to the radionuclides exceeding the bounds of the cutting layer caused by migration. (author)

  10. Family planning providers' role in offering PrEP to women.

    Science.gov (United States)

    Seidman, Dominika; Weber, Shannon; Carlson, Kimberly; Witt, Jacki

    2018-03-09

    Pre-exposure prophylaxis (PrEP) provides a radically different HIV prevention option for women. Not only is PrEP the first discrete, woman-controlled method that is taken in advance of exposure, but it is both safe and highly effective, offering over 90% protection if taken daily. While multiple modalities of PrEP are in development ranging from vaginal rings to injectables and implants, only PrEP with oral tenofovir/emtricitabine is currently FDA-approved. Family planning clinics provide key access points for many women to learn about and obtain PrEP. By incorporating PrEP services into family planning care, family planning providers have the opportunity to meet women's expectations, ensure women are aware of and offered comprehensive HIV prevention options, and reverse emerging disparities in PrEP access. Despite real and perceived barriers to integrating PrEP into family planning care, providing PrEP services, ranging from education to onsite provision, is not only possible but an important component of providing high-quality sexual and reproductive healthcare to women. Lessons learned from early adopters will help guide those in family planning settings initiating or enhancing PrEP services. Copyright © 2018. Published by Elsevier Inc.

  11. Comparison of different treatment planning optimization methods for vaginal HDR brachytherapy with multichannel applicators: A reduction of the high doses to the vaginal mucosa is possible.

    Science.gov (United States)

    Carrara, Mauro; Cusumano, Davide; Giandini, Tommaso; Tenconi, Chiara; Mazzarella, Ester; Grisotto, Simone; Massari, Eleonora; Mazzeo, Davide; Cerrotta, Annamaria; Pappalardi, Brigida; Fallai, Carlo; Pignoli, Emanuele

    2017-12-01

    A direct planning approach with multi-channel vaginal cylinders (MVCs) used for HDR brachytherapy of vaginal cancers is particularly challenging. Purpose of this study was to compare the dosimetric performances of different forward and inverse methods used for the optimization of MVC-based vaginal treatments for endometrial cancer, with a particular attention to the definition of strategies useful to limit the high doses to the vaginal mucosa. Twelve postoperative vaginal HDR brachytherapy treatments performed with MVCs were considered. Plans were retrospectively optimized with three different methods: Dose Point Optimization followed by Graphical Optimization (DPO + GrO), Inverse Planning Simulated Annealing with two different class solutions as starting conditions (surflPSA and homogIPSA) and Hybrid Inverse Planning Optimization (HIPO). Several dosimetric parameters related to target coverage, hot spot extensions and sparing of organs at risk were analyzed to evaluate the quality of the achieved treatment plans. Dose homogeneity index (DHI), conformal index (COIN) and a further parameter quantifying the proportion of the central catheter loading with respect to the overall loading (i.e., the central catheter loading index: CCLI) were also quantified. The achieved PTV coverage parameters were highly correlated with each other but uncorrelated with the hot spot quantifiers. HomogIPSA and HIPO achieved higher DHIs and CCLIs and lower volumes of high doses than DPO + GrO and surflPSA. Within the investigated optimization methods, HIPO and homoglPSA showed the highest dose homogeneity to the target. In particular, homogIPSA resulted also the most effective in reducing hot spots to the vaginal mucosa. Copyright © 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

  12. Possible Overestimation of Surface Disinfection Efficiency by Assessment Methods Based on Liquid Sampling Procedures as Demonstrated by In Situ Quantification of Spore Viability ▿

    Science.gov (United States)

    Grand, I.; Bellon-Fontaine, M.-N.; Herry, J.-M.; Hilaire, D.; Moriconi, F.-X.; Naïtali, M.

    2011-01-01

    The standard test methods used to assess the efficiency of a disinfectant applied to surfaces are often based on counting the microbial survivors sampled in a liquid, but total cell removal from surfaces is seldom achieved. One might therefore wonder whether evaluations of microbial survivors in liquid-sampled cells are representative of the levels of survivors in whole populations. The present study was thus designed to determine the “damaged/undamaged” status induced by a peracetic acid disinfection for Bacillus atrophaeus spores deposited on glass coupons directly on this substrate and to compare it to the status of spores collected in liquid by a sampling procedure. The method utilized to assess the viability of both surface-associated and liquid-sampled spores included fluorescence labeling with a combination of Syto 61 and Chemchrome V6 dyes and quantifications by analyzing the images acquired by confocal laser scanning microscopy. The principal result of the study was that the viability of spores sampled in the liquid was found to be poorer than that of surface-associated spores. For example, after 2 min of peracetic acid disinfection, less than 17% ± 5% of viable cells were detected among liquid-sampled cells compared to 79% ± 5% or 47% ± 4%, respectively, when the viability was evaluated on the surface after or without the sampling procedure. Moreover, assessments of the survivors collected in the liquid phase, evaluated using the microscopic method and standard plate counts, were well correlated. Evaluations based on the determination of survivors among the liquid-sampled cells can thus overestimate the efficiency of surface disinfection procedures. PMID:21742922

  13. Possible overestimation of surface disinfection efficiency by assessment methods based on liquid sampling procedures as demonstrated by in situ quantification of spore viability.

    Science.gov (United States)

    Grand, I; Bellon-Fontaine, M-N; Herry, J-M; Hilaire, D; Moriconi, F-X; Naïtali, M

    2011-09-01

    The standard test methods used to assess the efficiency of a disinfectant applied to surfaces are often based on counting the microbial survivors sampled in a liquid, but total cell removal from surfaces is seldom achieved. One might therefore wonder whether evaluations of microbial survivors in liquid-sampled cells are representative of the levels of survivors in whole populations. The present study was thus designed to determine the "damaged/undamaged" status induced by a peracetic acid disinfection for Bacillus atrophaeus spores deposited on glass coupons directly on this substrate and to compare it to the status of spores collected in liquid by a sampling procedure. The method utilized to assess the viability of both surface-associated and liquid-sampled spores included fluorescence labeling with a combination of Syto 61 and Chemchrome V6 dyes and quantifications by analyzing the images acquired by confocal laser scanning microscopy. The principal result of the study was that the viability of spores sampled in the liquid was found to be poorer than that of surface-associated spores. For example, after 2 min of peracetic acid disinfection, less than 17% ± 5% of viable cells were detected among liquid-sampled cells compared to 79% ± 5% or 47% ± 4%, respectively, when the viability was evaluated on the surface after or without the sampling procedure. Moreover, assessments of the survivors collected in the liquid phase, evaluated using the microscopic method and standard plate counts, were well correlated. Evaluations based on the determination of survivors among the liquid-sampled cells can thus overestimate the efficiency of surface disinfection procedures.

  14. Possibilities of surface-sensitive X-ray methods for studying the molecular mechanisms of interaction of nanoparticles with model membranes

    Energy Technology Data Exchange (ETDEWEB)

    Novikova, N. N., E-mail: nn-novikova07@yandex.ru; Kovalchuk, M. V.; Yakunin, S. N. [National Research Centre “Kurchatov Institute,” (Russian Federation); Konovalov, O. V. [European Synchrotron Radiation Facility (France); Stepina, N. D. [Russian Academy of Sciences, Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” (Russian Federation); Rogachev, A. V. [National Research Centre “Kurchatov Institute,” (Russian Federation); Yurieva, E. A. [Moscow Research Institute of Pediatrics and Pediatric Surgery (Russian Federation); Marchenko, I. V.; Bukreeva, T. V. [National Research Centre “Kurchatov Institute,” (Russian Federation); Ivanova, O. S.; Baranchikov, A. E.; Ivanov, V. K. [Russian Academy of Sciences, Kurnakov Institute of General and Inorganic Chemistry (Russian Federation)

    2016-09-15

    The processes of structural rearrangement in a model membrane, i.e., an arachic acid monolayer formed on a colloidal solution of cerium dioxide or magnetite, are studied in situ in real time by the methods of X-ray standing waves and 2D diffraction. It is shown that the character of the interaction of nanoparticles with the monolayer is determined by their nature and sizes and depends on the conditions of nanoparticle synthesis. In particular, the structure formation in the monolayer–particle system is greatly affected by the stabilizer (citric acid), which is introduced into the colloidal solution during synthesis.

  15. Benefits and challenges perceived by patients with cancer when offered a nurse navigator

    Directory of Open Access Journals (Sweden)

    Marianne Kirstine Thygesen

    2011-10-01

    Full Text Available Introduction: Lack of communication, care and respect from healthcare professionals can be challenges for patients in trajectories of cancer, possibly accompanied by experienced fragmentation of the care, anxiety and worries. One way to try to improve delivery of care is additional help from Nurse Navigators (NN offered in a predefined shorter or longer period, but patients´ experiences with this have seldom been investigated. Aims: To explore patients´ experiences of an NN offered in a short period of a longer trajectory of cancer. Methods: NN worked from the hospital side in the transition between primary care and a university hospital before admission. A phenomenological-hermeneutical longitudinal study was performed from referral and until two months after discharge from the hospital. Semi-structured interviews provided data for the analysis, which started open-minded. Results:  Affectional bonds were made to NN and patients felt that they benefited from her presence and her help, which they requested until one month after discharge. They were deeply disappointed and felt rejected when the contact to the NN stopped. Conclusion: In efforts to increase quality of care for patients with cancer we recommend paying special attention to critical periods in their trajectories, as well as to the theory of attachment to supplement thoughts of continuity of care and coordination in the care for women. In short, it is fine to offer additional help to those who can use it, but in practice as well as in research we call attention to awareness on how and when to stop the help, to prevent patients from feeling hurt.

  16. Nutrient offerings from the meals and snacks served in four daycare centers in Guatemala City.

    NARCIS (Netherlands)

    Vossenaar, M.; Panday, B.; Hamelinck, V.; Soto-Méndez, M.J.; Doak, C.M.; Solomons, N.W.

    2011-01-01

    Objective: To assess the nutritional content and contribution to recommended nutrient intakes of the menu offerings in diverse daycare centers serving low-income urban families in Guatemala City. Methods: An observational study design was used to record all food and drink items offered to children

  17. Photocatalytic properties of BiVO{sub 4} prepared by the co-precipitation method: Degradation of rhodamine B and possible reaction mechanisms under visible irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-de la Cruz, A., E-mail: azael70@yahoo.com.mx [Facultad de Ingenieria Mecanica y Electrica, Universidad Autonoma de Nuevo Leon, Ciudad Universitaria, C.P. 66451, San Nicolas de los Garza, N.L. (Mexico); Perez, U.M. Garcia [Facultad de Ingenieria Mecanica y Electrica, Universidad Autonoma de Nuevo Leon, Ciudad Universitaria, C.P. 66451, San Nicolas de los Garza, N.L. (Mexico)

    2010-02-15

    Bismuth vanadate (BiVO{sub 4}) was synthesized by the co-precipitation method at 200 {sup o}C. The photocatalytic activity of the oxide was tested for the photodegradation of rhodamine B under visible light irradiation. The analysis of the total organic carbon showed that the mineralization of rhodamine B over a BiVO{sub 4} photocatalyst ({approx}40% after 100 h of irradiation) is feasible. In the same way, a gas chromatography analysis coupled with mass spectroscopy revealed the existence of organic intermediates during the photodegradation process such as ethylbenzene, o-xylene, m-xylene, and phthalic anhydride. The modification of variables such as dispersion pH, amount of dissolved O{sub 2}, and irradiation source was studied in order to know the details about the photodegradation mechanism.

  18. Photocatalytic properties of BiVO4 prepared by the co-precipitation method: Degradation of rhodamine B and possible reaction mechanisms under visible irradiation

    International Nuclear Information System (INIS)

    Martinez-de la Cruz, A.; Perez, U.M. Garcia

    2010-01-01

    Bismuth vanadate (BiVO 4 ) was synthesized by the co-precipitation method at 200 o C. The photocatalytic activity of the oxide was tested for the photodegradation of rhodamine B under visible light irradiation. The analysis of the total organic carbon showed that the mineralization of rhodamine B over a BiVO 4 photocatalyst (∼40% after 100 h of irradiation) is feasible. In the same way, a gas chromatography analysis coupled with mass spectroscopy revealed the existence of organic intermediates during the photodegradation process such as ethylbenzene, o-xylene, m-xylene, and phthalic anhydride. The modification of variables such as dispersion pH, amount of dissolved O 2 , and irradiation source was studied in order to know the details about the photodegradation mechanism.

  19. Contact method or automated immersion technique: possible application and limitations of ultrasonic testing in the fusion reactor; Kontakttechnik oder automatisierte Tauchtechnik. Einsatzmoeglichkeiten und Beschraenkungen der Ultraschallpruefung im Fusionsreaktor

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Tatiana; Knaak, Stefan; Aktaa, Jarir [Karlsruher Institut fuer Technologie (KIT), Eggenstein-Leopoldshafen (Germany). Inst. fuer Angewandte Materialien Werkstoff- und Biomechanik (IAM-WBM); Rey, Joerg; Neuberger, Heiko [Karlsruher Institut fuer Technologie (KIT), Eggenstein-Leopoldshafen (Germany). Inst. fuer Neutronenphysik und Reaktortechnik (INR); Krueger, Friedhelm [Krueger Erodiertechnik GmbH und Co.KG, Biedenkopf (Germany); Karlsruher Institut fuer Technologie (KIT), Eggenstein-Leopoldshafen (Germany)

    2014-11-01

    The tritium breeding blanket is the most important component of a thermonuclear reactor combining the protective function against plasma impact and heat exchange. The breeding blanket concept is based on the use of helium as coolant and beryllium pebbles as neutron multiplier. As structural material the low-activation ferritic-martensitic steel EUROFER (9Cr-W-V-T) is used. For quality assurance the components of the breeding blankets are tested using different non-destructive testing methods. The contact methodology applies the testing equipment VEO in combination of the 10 MHz array-wheel sensor of the ultrasonic phased array series. Immersion testing is performed using the automated facility KC 200 from GE Inspection technologies.

  20. Possibility of application of low-frequency piezothromboelastografy method for the evaluation of haemostatic potential of blood in coronary bypass surgery on the background of long aspirinotherapy

    Directory of Open Access Journals (Sweden)

    Elena V. Fanaskova

    2017-01-01

    Full Text Available Aim. To assess the hemostatic system on the aspirin therapy background using the VerifyNow Aspirin test, as well as examining platelet aggregation and low-frequency piezothromboelastography in patients with coronary artery disease during coronary artery bypass grafting.Materials and methods. 100 people with coronary artery disease who were taking aspirin (75–100 mg daily for more than 1 year were examined. The study was performed in the perioperative period of coronary bypass surgery without aspirin withdrawal. Evaluation of hemostasis was performed by the VerifyNow Aspirin тest (USA, platelet aggregation (Нelena Laboratories AggRAMTM, Britain and the low-frequency piezothromboelastography (ARP-01M “Mednord”, Russia.Results. Patients included in the study were sensitive to aspirin when under long-term administration of a drug: indicator test was VerifyNow ARU 496,9 ± 21,3%, the platelet aggregation to ADP and adrenaline was reduced by 46% and 52%, respectively. In the early postoperative period platelet aggregation of ADP decreased by 73,2%, collagen – 75,9%, and adrenaline – 82,64% in comparison with the control group.Perioperative hemorrhagic complications in the study group were not observed. Reduction of platelet aggregation after aspirin therapy was accompanied by an increase in thrombin activity of the blood, which allows for evaluation of the method of low-frequency piezothromboelastography (LPTEG. In the early postoperative period, the results of LPTEG, thrombin potential, and anticoagulant and fibrinolytic activity of blood were partially normalized without reaching the level of the control group.Conclusion. For the evaluation of hemostasis under aspirin therapy it is advisable to apply the low-frequency piezothromboelastography, which in contrast to the VerifyNow test and traditional platelet aggregation, allows one to reveal a degree of impairment in thrombin blood activity and to conduct an integrative assessment on all

  1. Possibility of applying the gamma-gamma method to the in situ determination of uranium-ore densities; Les possibilites d'application de la methode gamma-gamma a la determination en place de la densite des minerais d'uranium

    Energy Technology Data Exchange (ETDEWEB)

    Czubek, J; Guitton, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1965-07-01

    The principles of the gamma-gamma method are reviewed. It is shown in particular that, under certain conditions, the method makes it possible to obtain a representative measurement of the electronic density. Chemical analyses have been carried out on samples obtained from uranium deposits. The results show that an exact correlation exists between the massive and electronic densities. It is possible to consider the possibility of measuring the density of uranium-containing rocks by the gamma-gamma method. (authors) [French] Les principes de la methode gamma-gamma sont rappeles. En particulier, il est montre que, dans certaines conditions, la methode permet une mesure representative de la densite electronique. Des analyses chimiques ont ete effectuees sur des echantillons provenant de gisements uraniferes. Les resultats indiquent qu'il existe une correlation precise entre leur densite massique et leur densite electronique. Il est possible d'envisager la mesure de la densite des roches uraniferes par la methode gamma-gamma.

  2. Information Uncertainty in Electricity Markets: Introducing Probabilistic Offers

    DEFF Research Database (Denmark)

    Papakonstantinou, Athanasios; Pinson, Pierre

    2016-01-01

    We propose a shift from the current paradigm of electricity markets treating stochastic producers similarly to conventional ones in terms of their offers. We argue that the producers’ offers should be probabilistic to reflect the limited predictability of renewable energy generation, while we...... should design market mechanisms to accommodate such offers. We argue that the transition from deterministic offers is a natural next step in electricity markets, by analytically proving our proposal’s equivalence with a two-price conventional market....

  3. Analysis of Polish internet retail sites offering electronic cigarettes.

    Science.gov (United States)

    Zarobkiewicz, Michał Konrad; Woźniakowski, Mateusz Mariusz; Sławiński, Mirosław Aleksander; Samborski, Patryk Michał; Wawryk-Gawda, Ewelina; Jodłowska-Jędrych, Barbara

    Electronic cigarettes as possibly healthier alternative to conventional cigarettes are gaining popularity worldwide, although they are still hazardous to human health. Partly it is caused by unregulated advertising and online sales. Unfortunately it is more and more popular for youth to try electronic cigarettes. The aim of the study was to assess the marketing claims used by Polish websites offering electronic cigarettes. A search using Google search engine was performed in July 2015 for two keywords: e-papierosy [e-cigarettes] and elektroniczne papierosy [electronic cigarettes]. First 150 websites (15 pages) were listed. After initial review 86 pages met all inclusion criteria and were included in the study. Pages were searched for presence of 13 selected marketing claims as well as age-related warning and any social websites connections. Age-related warning was present on only 33.72% (n=29) websites. Two thirds has its own Facebook fan-page with average 1922.09 ± 3634.86 likes. Articles about health are available on 10.46% (n=9) websites, 53.49% (n=46) states that e-cigarettes are healthier than conventional ones, 39.53% (n=34) emphasized that during usage of e-cigarettes no tarry substances are produced. Two pages had special article in which conventional and electronic cigarettes were compared. Almost half (44.19%) remarked that e-cigarettes are cheaper in usage than conventional, one third pointed out the simplicity of usage. 32.56% advertised e-cigarettes as aid in quitting smoking. One fourth stated that e-cigarettes are harmless for surroundings. 33.72% marketed them as a way of bypassing public smoking act. 56.98% remarked the variety of liquid tastes offered. Electronic cigarettes and their rising popularity create another new possible threat for public health as the widely available information emphasize safety of e-cigarettes usage and as their availability and usage is not limited or restricted by law. electronic cigarettes, e-cigarettes, internet

  4. Renewable energy sources offering flexibility through electricity markets

    DEFF Research Database (Denmark)

    Soares, Tiago

    governments. Renewable energy sources are characterized by their uncertain and variable production that limits the current operation and management tools of the power system. Nevertheless, recent developments of renewable energy technologies enable these resources to provide, to some extent, ancillary......All over the world, penetration of renewable energy sources in power systems has been increasing, creating new challenges in electricity markets and for operation and management of power systems, since power production from these resources is by nature uncertain and variable. New methods and tools...... in both energy and reserve markets. In this context, the main contribution of this thesis is the design and development of optimal offering strategies for the joint participation of renewables in the energy and reserve markets. Two distinct control policies for the splitting of available wind power...

  5. 48 CFR 852.273-70 - Late offers.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Late offers. 852.273-70... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 852.273-70 Late offers. As prescribed in 873.110(a), insert the following provision: Late Offers (JAN 2003) This provision replaces...

  6. 12 CFR 810.2 - Public notice of offering.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Public notice of offering. 810.2 Section 810.2 Banks and Banking FEDERAL FINANCING BANK FEDERAL FINANCING BANK BILLS § 810.2 Public notice of offering. On the occasion of an offering of FFB bills, tenders therefor will be invited through public notices...

  7. 14 CFR 13.225 - Offer of proof.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Offer of proof. 13.225 Section 13.225... INVESTIGATIVE AND ENFORCEMENT PROCEDURES Rules of Practice in FAA Civil Penalty Actions § 13.225 Offer of proof. A party whose evidence has been excluded by a ruling of the administrative law judge may offer the...

  8. 7 CFR 29.57 - Where inspection is offered.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Where inspection is offered. 29.57 Section 29.57... REGULATIONS TOBACCO INSPECTION Regulations Permissive Inspection § 29.57 Where inspection is offered. Tobacco..., samplers, or weighers are available and the tobacco is offered under conditions that permit of its proper...

  9. 34 CFR 101.85 - Offer of proof.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Offer of proof. 101.85 Section 101.85 Education... PRACTICE AND PROCEDURE FOR HEARINGS UNDER PART 100 OF THIS TITLE Hearing Procedures § 101.85 Offer of proof. An offer of proof made in connection with an objection taken to any ruling of the presiding officer...

  10. 48 CFR 19.804-2 - Agency offering.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Agency offering. 19.804-2....804-2 Agency offering. (a) After completing its evaluation, the agency must notify the SBA of the... statement that prior to the offering no solicitation for the specific acquisition has been issued as a small...

  11. 7 CFR 15.122 - Offer of proof.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Offer of proof. 15.122 Section 15.122 Agriculture..., Decisions and Administrative Review Under the Civil Rights Act of 1964 Hearing Procedures § 15.122 Offer of proof. An offer of proof made in connection with an objection taken to any ruling of the hearing officer...

  12. 14 CFR 406.155 - Offer of proof.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Offer of proof. 406.155 Section 406.155... Transportation Adjudications § 406.155 Offer of proof. A party whose evidence has been excluded by a ruling of the administrative law judge may offer the evidence for the record on appeal. ...

  13. 7 CFR 3431.17 - VMLRP service agreement offer.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false VMLRP service agreement offer. 3431.17 Section 3431... Administration of the Veterinary Medicine Loan Repayment Program § 3431.17 VMLRP service agreement offer. The Secretary will make an offer to successful applicants to enter into an agreement with the Secretary to...

  14. 5 CFR 339.302 - Authority to offer examinations.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Authority to offer examinations. 339.302... QUALIFICATION DETERMINATIONS Medical Examinations § 339.302 Authority to offer examinations. An agency may, at its option, offer a medical examination (including a psychiatric evaluation) in any situation where...

  15. 14 CFR 16.231 - Offer of proof.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Offer of proof. 16.231 Section 16.231... PRACTICE FOR FEDERALLY-ASSISTED AIRPORT ENFORCEMENT PROCEEDINGS Hearings § 16.231 Offer of proof. A party whose evidence has been excluded by a ruling of the hearing officer may offer the evidence on the record...

  16. 36 CFR 1150.79 - Offer of proof.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Offer of proof. 1150.79... BOARD PRACTICE AND PROCEDURES FOR COMPLIANCE HEARINGS Hearing Procedures § 1150.79 Offer of proof. An offer of proof made in connection with an objection taken to a ruling of the judge rejecting or...

  17. 31 CFR 309.6 - Public notice of offering.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Public notice of offering. 309.6 Section 309.6 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... Public notice of offering. When Treasury bills are to be offered, tenders therefor will be invited...

  18. 48 CFR 619.804-2 - Agency offering.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Agency offering. 619.804-2 Section 619.804-2 Federal Acquisition Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS SMALL... offering. (a) When applicable, this notification shall identify that the offering is in accordance with the...

  19. 47 CFR 76.1621 - Equipment compatibility offer.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Equipment compatibility offer. 76.1621 Section... MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Notices § 76.1621 Equipment compatibility offer. Cable system... offer to supply each subscriber with special equipment that will enable the simultaneous reception of...

  20. 48 CFR 12.602 - Streamlined evaluation of offers.

    Science.gov (United States)

    2010-10-01

    ... offers. 12.602 Section 12.602 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... for Commercial Items 12.602 Streamlined evaluation of offers. (a) When evaluation factors are used... evaluation factors. (b) Offers shall be evaluated in accordance with the criteria contained in the...

  1. 49 CFR 1503.641 - Offer of proof.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Offer of proof. 1503.641 Section 1503.641... Rules of Practice in TSA Civil Penalty Actions § 1503.641 Offer of proof. A party whose evidence has been excluded by a ruling of the ALJ may offer the evidence for the record on appeal. ...

  2. 14 CFR 151.29 - Procedures: Offer, amendment, and acceptance.

    Science.gov (United States)

    2010-01-01

    ... resolution or ordinance must, as appropriate under the local law— (1) Set forth the terms of the offer at... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Procedures: Offer, amendment, and... § 151.29 Procedures: Offer, amendment, and acceptance. (a) Upon approving a project, the Administrator...

  3. 17 CFR 230.155 - Integration of abandoned offerings.

    Science.gov (United States)

    2010-04-01

    ... offering disclose information about the abandoned private offering, including: (i) The size and nature of... were (or who the issuer reasonably believes were): (i) Accredited investors (as that term is defined in... document used in the private offering discloses any changes in the issuer's business or financial condition...

  4. 42 CFR 417.153 - Offer of HMO alternative.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Offer of HMO alternative. 417.153 Section 417.153... § 417.153 Offer of HMO alternative. (a) Basic rule. An employing entity that is subject to this subpart and that elects to include one or more qualified HMOs must offer the HMO alternative in accordance...

  5. 7 CFR 1494.601 - Acceptance of offers by CCC.

    Science.gov (United States)

    2010-01-01

    ... exporting countries; and the cost effectiveness of the payment of a CCC bonus amount in view of CCC's... exporter's offer by CCC but not later than 10 a.m. of the next business day after the date the offer was... accepted by CCC by 10 a.m. of the next business day after the date for which the offer was submitted for...

  6. 19 CFR 172.32 - Authority to accept offers.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Authority to accept offers. 172.32 Section 172.32 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE....32 Authority to accept offers. The authority to accept offers in compromise, subject to the...

  7. HPLC-UV Method for the Identification and Screening of Hydroquinone, Ethers of Hydroquinone and Corticosteroids Possibly Used as Skin-Whitening Agents in Illicit Cosmetic Products.

    Science.gov (United States)

    Gimeno, Pascal; Maggio, Annie-Françoise; Bancilhon, Marjorie; Lassu, Nelly; Gornes, Hervé; Brenier, Charlotte; Lempereur, Laurent

    2016-03-01

    Corticosteroids, hydroquinone and its ethers are regulated in cosmetics by the Regulation 1223/2009. As corticosteroids are forbidden to be used in cosmetics and cannot be present as contaminants or impurities, an identification of one of these illicit compounds deliberately introduced in these types of cosmetics is enough for market survey control. In order to quickly identify skin-whitening agents present in illegal cosmetics, this article proposes an HPLC-UV method for the identification and screening of hydroquinone, 3 ethers of hydroquinone and 39 corticosteroids that may be found in skin-whitening products. Two elution gradients were developed to separate all compounds. The main solvent gradient (A) allows the separation of 39 compounds among the 43 compounds considered in 50 min. Limits of detection on skin-whitening cosmetics are given. For compounds not separated, a complementary gradient elution (B) using the same solvents is proposed. Between 2004 and 2009, a market survey on "skin-whitening cosmetic" was performed on 150 samples and highlights that more than half of the products tested do not comply with the Cosmetic Regulation 1223/2009 (amending the Council Directive 76/768/EEC). © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  8. A kidney offer acceptance decision tool to inform the decision to accept an offer or wait for a better kidney.

    Science.gov (United States)

    Wey, Andrew; Salkowski, Nicholas; Kremers, Walter K; Schaffhausen, Cory R; Kasiske, Bertram L; Israni, Ajay K; Snyder, Jon J

    2018-04-01

    We developed a kidney offer acceptance decision tool to predict the probability of graft survival and patient survival for first-time kidney-alone candidates after an offer is accepted or declined, and we characterized the effect of restricting the donor pool with a maximum acceptable kidney donor profile index (KDPI). For accepted offers, Cox proportional hazards models estimated these probabilities using transplanted kidneys. For declined offers, these probabilities were estimated by considering the experience of similar candidates who declined offers and the probability that declining would lead to these outcomes. We randomly selected 5000 declined offers and estimated these probabilities 3 years post-offer had the offers been accepted or declined. Predicted outcomes for declined offers were well calibrated (offers been accepted, the probabilities of graft survival and patient survival were typically higher. However, these advantages attenuated or disappeared with higher KDPI, candidate priority, and local donor supply. Donor pool restrictions were associated with worse 3-year outcomes, especially for candidates with high allocation priority. The kidney offer acceptance decision tool could inform offer acceptance by characterizing the potential risk-benefit trade-off associated with accepting or declining an offer. © 2017 The American Society of Transplantation and the American Society of Transplant Surgeons.

  9. Evaluation of possible occurrence of mutation in MMR repair system genes in resistant and sensitiveclinical strains of Mycobacterium tuberculosisby using sequencing method

    Directory of Open Access Journals (Sweden)

    AmirPoyan Afzali

    2016-07-01

    Full Text Available Background:during recent years, the incidence and spread of drug resistance in Mycobacterium tuberculosis, the bacterium causing tuberculosis, has set this disease in World Health Organizationpriorities alignment of diseases like AIDS and hepatitis. Study of close examination of resistant and susceptible clinical strains genotypes is necessary to overcome drug resistance. Among the numerous repair systems, only there are limited number of encoding genes of DNA repair enzymes in Mycobacterium tuberculosis. Commonly these genes have been conserved and any changes among them likely increasethe mutation occurance due to the impossibility of correctionof spontaneous mutations insensitive strains of this bacteria.mut genes encodeDNA repairable enzymes.This study investigated the mutations in these genes and the effect of these mutations on tuberculosis drug resistance. Materials&Methods: In this study,of 29 available specimens,we were selected 8 susceptible strains and 21 resistantstrains andafter ordering appropriate primers and performing the proliferation reaction two types of amplicons produced which includingfragments of genes mut T2 and mut T4 and they were sent inorder to sequencing. Results:The results of chain reactionprimer represents an appropriate choice of primerswhich were investigated. Sequencing results showed that overall 73% of resistant strains that had been selected for study of mutT4gene, have no mutations in codons 48of mutT4 gene, and 70% of resistant strains have no GGA >>> CGA mutation at codon 58 of mutT2 gene. Conclusion: One of the strategies to overcome tuberculosis drug resistance is a close examination of genotypes of resistant and susceptible clinical strains. Results of this study was performedby examining changes in mut T2 and mut T4 gene sequence. The mutation in mut T2 always associated with mutation in mut T4, in this way, the first mutation may occurs in mut T4and after that, the second mutationmay occurs in mut T

  10. Chlorinated paraffin analysis by gas chromatography Orbitrap high-resolution mass spectrometry: Method performance, investigation of possible interferences and analysis of fish samples.

    Science.gov (United States)

    Krätschmer, Kerstin; Cojocariu, Cristian; Schächtele, Alexander; Malisch, Rainer; Vetter, Walter

    2018-03-02

    For decades, high quantities of short-chain chlorinated paraffins (SCCP) and medium-chain chlorinated paraffins (MCCP) have been widely used, for instance as plasticizers or flame retardants, leading to global pollution due to unintentional emissions from products or waste. Due to the high complexity of chlorinated paraffins with several thousand congeners there is no consensus on an analytical procedure for SCCPs and MCCPs in food samples. Amongst the multitude of methods currently in use, high-resolution mass spectrometry is particularly valuable for in-depth studies of homologue patterns. Here we analyse SCCPs and MCCPs with gas chromatography coupled to high-resolution Orbitrap mass spectrometry (GC-Orbitrap-HRMS) operated in full-scan acquisition in electron capture negative ion (ECNI) mode at 60,000 and 120,000 resolution (FWHM, m/z 200, equals roughly 30,000 and 60,000 at 5% peak height). Linear dynamic range, selectivity and sensitivity tests confirmed an excellent linearity in a concentration range of 25-15,000 pg/μL with very low limits of detection (LODs) in the low pg/μL range. Spiking experiments with high levels of native mono- and di-ortho-polychlorinated biphenyls (PCBs) and mixtures of MCCP and SCCP standards did not have a negative impact on isotope ratios of the examined homologues. Besides the [M-Cl] - fragment ions used for quantification, the mass spectra of homologues also featured [M-HCl] - ions whose abundance increased with decreasing chlorination degree. In addition, [M-HCl-Cl] - ions were detected with a relative abundance of 5-10%. Three salmon (Salmo salar) samples farmed in Norway showed a consistent CP homologue pattern which differed both from the CP pattern in a sample from Scottish aquaculture and a wild salmon sample. These measurements produce evidence that discretely different CP patterns may exist in different areas of origin. Our results demonstrate that GC/ECNI-Orbitrap-HRMS is well-suited for the analysis of CPs by

  11. The possibilities and limitations of neuronavigation method in the treatment of intracranial pathology, on the basis of anatomic registering markers and preoperative magnetic resonance imaging

    International Nuclear Information System (INIS)

    Lickendorf, M.

    2007-01-01

    Introduction: The evaluation of technical parameters of the system and the evaluation of the influence of changing intraoperative conditions on the accuracy of the indications of the neuronavigational system has the key meaning in the effectiveness on the work of a neurosurgeon. On the other hand the employment of neuronavigation during an operation on the brain allows to get an insight into the dynamics and directions of the shifts of individual brain structures in regard to themselves and hard integuments. Material and methods: In the experimental part of the work an analysis was done of the theoretical and actual accuracy of indications of the neuronavigational system obtained after the registering process in modal and clinical conditions. In the clinical part of the work, during the operations of 69 patients with the use of the neuronavigational system an analysis was done of the dynamics and the direction of shifts of the brain's surface and the boundaries of pathological focus in regard to the placement and volume of the pathological focus, volume of the peritumorous edema and the usage of the escape of the cerebrospinal fluid, as well as resulting from those shifts the divergence in the indications of the neuronavigational system. Results and conclusions: A smaller accuracy of the neuronavigational system in clinical than in modal conditions was proved. Anatomical registering markers cause the shifts of areas of greatest accuracy to the face area of patients, not including in its range the back sides of the head and there localized 65.4% of pathological focuses. In model and clinical conditions significant differences between computer error of the RMSE registering process and the marker localization error empirically defined were proved. In result of the analysis of the shifts of the cerebral cortex during the operation of tumors: Meta, Astr. II, Astr. III, GBM, vascular and intrachamberal it was proved that the peritumorous edema, the volume of the

  12. Negotiating for more: the multiple equivalent simultaneous offer.

    Science.gov (United States)

    Heller, Richard E

    2014-02-01

    Whether a doctor, professional baseball manager, or a politician, having successful negotiation skills is a critical part of being a leader. Building upon prior journal articles on negotiation strategy, the author presents the concept of the multiple equivalent simultaneous offer (MESO). The concept of a MESO is straightforward: as opposed to making a single offer, make multiple offers with several variables. Each offer alters the different variables, such that the end result of each offer is equivalent from the perspective of the party making the offer. Research has found several advantages to the use of MESOs. For example, using MESOs, an offer was more likely to be accepted, and the counterparty was more likely to be satisfied with the negotiated deal. Additional benefits have been documented as well, underscoring why a prepared radiology business leader should understand the theory and practice of MESO. Copyright © 2014 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  13. Google Maps offers a new way to evaluate claudication.

    Science.gov (United States)

    Khambati, Husain; Boles, Kim; Jetty, Prasad

    2017-05-01

    Accurate determination of walking capacity is important for the clinical diagnosis and management plan for patients with peripheral arterial disease. The current "gold standard" of measurement is walking distance on a treadmill. However, treadmill testing is not always reflective of the patient's natural walking conditions, and it may not be fully accessible in every vascular clinic. The objective of this study was to determine whether Google Maps, the readily available GPS-based mapping tool, offers an accurate and accessible method of evaluating walking distances in vascular claudication patients. Patients presenting to the outpatient vascular surgery clinic between November 2013 and April 2014 at the Ottawa Hospital with vasculogenic calf, buttock, and thigh claudication symptoms were identified and prospectively enrolled in our study. Onset of claudication symptoms and maximal walking distance (MWD) were evaluated using four tools: history; Walking Impairment Questionnaire (WIQ), a validated claudication survey; Google Maps distance calculator (patients were asked to report their daily walking routes on the Google Maps-based tool runningmap.com, and walking distances were calculated accordingly); and treadmill testing for onset of symptoms and MWD, recorded in a double-blinded fashion. Fifteen patients were recruited for the study. Determination of walking distances using Google Maps proved to be more accurate than by both clinical history and WIQ, correlating highly with the gold standard of treadmill testing for both claudication onset (r = .805; P Google Maps tool was also efficient, with reporting times averaging below 4 minutes. For vascular claudicants with no other walking limitations, Google Maps is a promising new tool that combines the objective strengths of the treadmill test and incorporates real-world walking environments. It offers an accurate, efficient, inexpensive, and readily accessible way to assess walking distances in patients with

  14. Satellite communications: possibilities and problems

    International Nuclear Information System (INIS)

    Hine, M.

    1986-01-01

    Communication links via satellites are becoming available in Europe, both as part of the development of the telephone system and as special services aimed at data traffic. They offer the possibility of speeds between 50 kb/s and 2 Mb/s, without the problems and long term commitments of long distance land lines. Such links are provided by the PTT's as circuits which can be booked for variable periods, and have error rates which can be very low and well controlled. Problems in networking can arise from the satellite delay, particularly if errors occur in the local connections, and from the leased circuit and tariff philosophies of the PTT's. (Auth.)

  15. 43 CFR 4.840 - Offer of proof.

    Science.gov (United States)

    2010-10-01

    ... the Interior-Effectuation of Title VI of the Civil Rights Act of 1964 Hearing § 4.840 Offer of proof. An offer of proof made in connection with an objection taken to any ruling of the administrative law... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Offer of proof. 4.840 Section 4.840 Public...

  16. Offer and Acceptance of Apology in Victim-Offender Mediation

    OpenAIRE

    Dhami, MK; Dhami, MK

    2012-01-01

    Past research on restorative justice (RJ) has highlighted the importance of apology for both victims and offenders and the prevalence of apology during the RJ process. The present study moves this work further by examining the nature of the apologies that are offered during victim-offender mediation, as well as the individual-, case-, and mediation-level factors that can affect the offer and acceptance of apology. In addition, we measure the implications that the offer and acceptance of apolo...

  17. Triple Play Service and IPTV Services Offered within it

    Directory of Open Access Journals (Sweden)

    Dagmar Pajdusakova

    2008-01-01

    Full Text Available This paper deals with Triple Play multimedia service and figures its architecture. Triple Play offers voice, video and data services together in one customer connection. There is offered IPTV (Internet Protocol Television service within this service, where we can include also Video on Demand service and other different additional services. In the paper is described classification of Video on Demand services.

  18. 20 CFR 655.120 - Offered wage rate.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Offered wage rate. 655.120 Section 655.120... the United States (H-2A Workers) Prefiling Procedures § 655.120 Offered wage rate. (a) To comply with... wage that is the highest of the AEWR, the prevailing hourly wage or piece rate, the agreed-upon...

  19. Christus' offer bij Paulus vergeleken met de offeropvattingen van Philo

    NARCIS (Netherlands)

    Stelma, Juurd Hari

    1938-01-01

    Een vergelijking der offeropvattingen van Paulus en Philo brengt ons in aanraking met twee principieel verschillende voorstellingen aangaande het offer. Het offer van Christus is voor Paulus de gave Gods, waardoor de macht van de zonde en dood vernietigd en de schuld verzoend is. Door de

  20. 48 CFR 53.301-33 - Solicitation, Offer and Award.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Solicitation, Offer and Award. 53.301-33 Section 53.301-33 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Illustrations of Forms 53.301-33 Solicitation, Offer and Award. ER09DE97...

  1. University Offer Rates for Candidates from Different Ethnic Categories

    Science.gov (United States)

    Noden, Philip; Shiner, Michael; Modood, Tariq

    2014-01-01

    Previous research suggested that candidates from some black and minority ethnic groups were less likely to receive an offer of a place from an "old" university. These findings were disputed in a re-analysis carried out for HEFCE which found that only Pakistani candidates were significantly less likely to receive offers (from both…

  2. 7 CFR 58.5 - Where service is offered.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Where service is offered. 58.5 Section 58.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Grading Service § 58.5 Where service is offered. Subject to the provisions of this part, inspection or...

  3. 14 CFR 151.121 - Procedures: Offer; sponsor assurances.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Procedures: Offer; sponsor assurances. 151.121 Section 151.121 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Engineering Proposals § 151.121 Procedures: Offer; sponsor assurances. Each sponsor must adopt the following...

  4. 15 CFR 90.13 - Offer of hearing.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Offer of hearing. 90.13 Section 90.13 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade BUREAU OF THE CENSUS, DEPARTMENT OF COMMERCE PROCEDURE FOR CHALLENGING CERTAIN POPULATION AND INCOME ESTIMATES § 90.13 Offer of...

  5. 9 CFR 592.22 - Where service is offered.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Where service is offered. 592.22 Section 592.22 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS General § 592.22 Where service is offered...

  6. 45 CFR 2544.115 - Who may offer a donation?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Who may offer a donation? 2544.115 Section 2544... COMMUNITY SERVICE SOLICITATION AND ACCEPTANCE OF DONATIONS § 2544.115 Who may offer a donation? Anyone... donation to the Corporation. ...

  7. 17 CFR 230.419 - Offerings by blank check companies.

    Science.gov (United States)

    2010-04-01

    ... derivative securities relating to securities held in the escrow or trust account may be exercised or... other derivative securities issued in the initial offering are exercisable, there is a continuous... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Offerings by blank check...

  8. Assuring Quality in Online Offerings: Insights from a University's Faculty

    Science.gov (United States)

    Budden, Connie B.; Budden, Heather L.; Hall, Michelle; Longman, Debbie G.

    2015-01-01

    As the growth of online education offered by universities accelerates and spreads, universities are increasingly grappling with concerns related to widespread availability and the maintenance of academic quality. The "Quality Matters at Southeastern" Program fosters quality through a peer review process and offers a certification process…

  9. Perceived value creation process: focus on the company offer

    Directory of Open Access Journals (Sweden)

    Irena Pandža Bajs

    2012-12-01

    Full Text Available In the competitive business environment, as the number of rational consumers faced with many choices increases, companies can achieve their dominance best by applying the business concepts oriented to consumers in order to deliver a value which is different and better than that of their competitors. Among the various products on the market, an educated consumer chooses the offer that provides the greatest value for him/her. Therefore, it is essential for each company to determine how consumers perceive the value of its offer, and which factors determine the high level of perceived value for current and potential consumers. An analysis of these factors provides guidance on how to improve the existing offer and what the offer to be delivered in the future should be like. That could increase the perceived value of the company offer and result in a positive impact on consumer satisfaction and on establishing a stronger, longterm relationship with consumers. The process of defining the perceived value of a particular market offer is affected by the factors of the respective company’s offer as well as by competition factors, consumer factors and buying process factors. The aim of this paper is to analyze the relevant knowledge about the process of creating the perceived value of the company’s market offer and the factors that influence this process. The paper presents a conceptual model of the perceived value creation process in consumers’ mind.

  10. 48 CFR 252.217-7002 - Offering property for exchange.

    Science.gov (United States)

    2010-10-01

    ... exchange. 252.217-7002 Section 252.217-7002 Federal Acquisition Regulations System DEFENSE ACQUISITION... of Provisions And Clauses 252.217-7002 Offering property for exchange. As prescribed in 217.7005, use the following provision: Offering Property for Exchange (DEC 1991) (a) The property described in item...

  11. 31 CFR 50.13 - Offer, purchase, and renewal.

    Science.gov (United States)

    2010-07-01

    ... Section 50.13 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK INSURANCE PROGRAM Disclosures as Conditions for Federal Payment § 50.13 Offer, purchase, and renewal. An insurer is deemed to be in compliance with the requirement of providing disclosure “at the time of offer, purchase...

  12. 20 CFR 655.122 - Contents of job offers.

    Science.gov (United States)

    2010-04-01

    ... less than the same benefits, wages, and working conditions that the employer is offering, intends to... worker on a day during the work contract period is less than the number of hours offered, as specified in... the records for not less than 3 years after the date of the certification. (k) Hours and earnings...

  13. 31 CFR 342.0 - Offering of notes.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Offering of notes. 342.0 Section 342.0 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE... or greater denomination. This offering was effective from May 1, 1967 until the close of business...

  14. Improved understanding of protein complex offers insight into DNA

    Science.gov (United States)

    Summer Science Writing Internship Improved understanding of protein complex offers insight into DNA clearer understanding of the origin recognition complex (ORC) - a protein complex that directs DNA replication - through its crystal structure offers new insight into fundamental mechanisms of DNA replication

  15. Theoretical and Methodological Considerations on the Public Offers

    OpenAIRE

    Claudia Catalina SAVA

    2013-01-01

    This paper describes the most important characteristics of the public offers, both from the theoretical and methodological view. The European Union emphasizes clarity and transparency. The author focuses on specific provisions of European Directive and Romanian law and regulations related to voluntary and mandatory takeover bids, on characteristics such as price, offeror and offeeree right, offer timetable.

  16. 48 CFR 52.247-51 - Evaluation of Export Offers.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Evaluation of Export....247-51 Evaluation of Export Offers. As prescribed in 47.305-6(e), insert the following provision: Evaluation of Export Offers (JAN 2001) (a) Port handling and ocean charges—other than DOD water terminals...

  17. Negotiation as a form of persuasion: arguments in first offers.

    Science.gov (United States)

    Maaravi, Yossi; Ganzach, Yoav; Pazy, Asya

    2011-08-01

    In this article we examined aspects of negotiation within a persuasion framework. Specifically, we investigated how the provision of arguments that justified the first offer in a negotiation affected the behavior of the parties, namely, how it influenced counteroffers and settlement prices. In a series of 4 experiments and 2 pilot studies, we demonstrated that when the generation of counterarguments was easy, negotiators who did not add arguments to their first offers achieved superior results compared with negotiators who used arguments to justify their first offer. We hypothesized and provided evidence that adding arguments to a first offer was likely to cause the responding party to search for counterarguments, and this, in turn, led him or her to present counteroffers that were further away from the first offer.

  18. High-testosterone men reject low ultimatum game offers.

    Science.gov (United States)

    Burnham, Terence C

    2007-09-22

    The ultimatum game is a simple negotiation with the interesting property that people frequently reject offers of 'free' money. These rejections contradict the standard view of economic rationality. This divergence between economic theory and human behaviour is important and has no broadly accepted cause. This study examines the relationship between ultimatum game rejections and testosterone. In a variety of species, testosterone is associated with male seeking dominance. If low ultimatum game offers are interpreted as challenges, then high-testosterone men may be more likely to reject such offers. In this experiment, men who reject low offers ($5 out of $40) have significantly higher testosterone levels than those who accept. In addition, high testosterone levels are associated with higher ultimatum game offers, but this second finding is not statistically significant.

  19. Initial Public Offering – Finance Source of Stock

    Directory of Open Access Journals (Sweden)

    Sorin Claudiu Radu

    2013-10-01

    Full Text Available Capital market offers a wide range of options for financing companies, which can be tailored to meet their exact needs. Thus, they have the opportunity of primary security sale (shares and bonds on the stock exchange, which may take place through a tender, in which case the financial instruments issued by a company are underwritten at the date of issue, or through a secondary offer, in which case they are issued and offered for sale by the issuer. If the public sale offer focuses on shares and aims at transforming the issuing company into a public one, then it bears the name of IPO (Initial Public Offering. The present work aims for the evolution of IPO trends on the European market in the aftermath of the global crisis outbreak. The market of IPO carried out by BSE is also analyzed herewith.

  20. A decision analytical cost analysis of offering ECV in a UK district general hospital

    Directory of Open Access Journals (Sweden)

    Burr Robin

    2001-07-01

    Full Text Available Abstract Objective To determine the care pathways and implications of offering mothers the choice of external cephalic version (ECV at term for singleton babies who present with an uncomplicated breech pregnancy versus assisted breech delivery or elective caesarean. Design A prospective observational audit to construct a decision analysis of uncomplicated full term breech presentations. Setting The North Staffordshire NHS Trust. Subjects All women (n = 176 who presented at full term with a breech baby without complications during July 1995 and June 1997. Main outcome measures The study determined to compare the outcome in terms of the costs and cost consequences for the care pathways that resulted from whether a women chose to accept the offer of ECV or not. All the associated events were then mapped for the two possible pathways. The costs were considered only within the hospital setting, from the perspective of the health care provider up to the point of delivery. Results The additional costs for ECV, assisted breech delivery and elective caesarean over and above a normal birth were £186.70, £425.36 and £1,955.22 respectively. The total expected cost of the respective care pathways for "ECV accepted" and "ECV not accepted" (including the probability of adverse events were £1,452 and £1,828 respectively, that is the cost of delivery through the ECV care pathways is less costly than the non ECV delivery care pathway. Conclusions Implementing an ECV service may yield cost savings in secondary care over and above the traditional delivery methods for breech birth of assisted delivery or caesarean section. The scale of these expected cost savings are in the range of £248 to £376 per patient. This converts to a total expected cost saving of between £43,616 and £44,544 for the patient cohort considered in this study.

  1. School Music Advocates Go Straight to Video: Online Services like SchoolTube Offer Far-Reaching Possibilities

    Science.gov (United States)

    Block, Debbie Galante

    2009-01-01

    A few years ago, Bill Pendziwiatr of Crestwood School District in Pennsylvania helped create a video documenting six local music programs, including snippets of rehearsals and performances by choirs, traditional bands, jazz and rock ensembles, orchestras, even a clapping class. His goal was to distribute the video all over the state so that…

  2. New possibilities in hydrological monitoring offered by experiences of Citizen Science: CITHYD, a web application for hydrometric measurements in rivers

    Science.gov (United States)

    Galimberti, Giacomo; Balbo, Alessandro

    2017-04-01

    In addition to the data commonly used in hydrological predictions (such as the peaks over a threshold or the annual maximum series or the daily average values of the variables of interest), it is now clear the importance of using all available information, integrating different kinds of data, with appropriate methodologies, including non-systematic measurements and historical values recorded in the past. This is of particular interest in ungauged or poorly gauged basins, often of small size, where there are very few data, but often high hydraulic risk. The wide spread of technologies and sensors useful for data collection (e.g. via smartphones) enable the involvement of citizens in the measurement, transmission and analysis of data. The research concerns the development of a web - application, called CITHYD (Citizen Hydrology) for the collection of hydrometric measurements in rivers from citizens. CITHYD is an application that receives water level data, collected and sent by citizens, in river cross sections instrumented with a staff gauge and an information panel, performs simple reliability checks, stores the data, publishes them and creates statistics freely available for all (under Italian Open Data License 2.0). The application needs an information panel containing a unique QR code for every staff gauge. Through smartphones and TLC network the citizen can transmit the water level seen on a staff gauge existing on a river basin to a geodatabase with web interface. The user, thanks to the QR code, immediately accesses the data entry mask form related to that staff gauge and can insert the water level just read. Data are published almost in real time on a map and the data, inserted by all users, can be read and downloaded, as text files, tables and graphics. The Open Data stored in the DB can be used for scientific research, for calibration and validation of models, to improve the knowledge of the territory and for planning and design. The Citizen Science experience supports the involvement of local communities in living and take care of the rivers of their territory and can promote the creation of a virtuous circle in data collection through social networks, educational and communication events. It can also be used during emergencies, by authorized users, to collect level measurements for risk management and flood protection. The application has been fully developed and is now at the end of the testing phase. Some Italian local administrations are evaluating the use of CITHYD in small catchments in their territories in order to improve community engagement and resilience.

  3. (Block) Chain Reaction: A Blockchain Revolution Sweeps into Health Care, Offering the Possibility for a Much-Needed Data Solution.

    Science.gov (United States)

    Mertz, Leslie

    2018-01-01

    Electronic health records may have digitized patient data, but getting that data from one clinician to another remains a huge challenge, especially since patients often have multiple doctors ordering tests, prescribing drugs, and providing treatment. Many experts now believe that blockchain technology might be just the thing to get a patient's pertinent medical information from where it is stored to where it is needed, as well as to allow patients to easily view their own medical histories. In addition, blockchain technology might also be able to help with other aspects of health care, such as improving the insurance claim or other administrative processes within healthcare networks and making health-related population data available to biomedical researchers.

  4. Robotic Transversus Abdominis Release (TAR: is it possible to offer minimally invasive surgery for abdominal wall complex defects?

    Directory of Open Access Journals (Sweden)

    MARIA VITÓRIA FRANÇA DO AMARAL

    Full Text Available ABSTRACT We describe the preliminary national experience and the early results of the use of robotic surgery to perform the posterior separation of abdominal wall components by the Transversus Abdominis Release (TAR technique for the correction of complex defects of the abdominal wall. We performed the procedures between 04/2/2015 and 06/15/2015 and the follow-up time was up to six months, with a minimum of two months. The mean surgical time was five hours and 40 minutes. Two patients required laparoscopic re-intervention, since one developed hernia by peritoneal migration of the mesh and one had mesh extrusion. The procedure proved to be technically feasible, with a still long surgical time. Considering the potential advantages of robotic surgery and those related to TAR and the results obtained when these two techniques are associated, we conclude that they seem to be a good option for the correction of complex abdominal wall defects.

  5. Evaluating alternative offering strategies for wind producers in a pool

    International Nuclear Information System (INIS)

    Rahimiyan, Morteza; Morales, Juan M.; Conejo, Antonio J.

    2011-01-01

    Highlights: → Out-of-sample analysis allows comparing diverse offers using real-world data. → Offering the best production forecast is not optimal for a wind producer. → Stochastic programming offers lead to maximum expected profit. → Offering the best production forecast is not generally optimal for risk control. → Stochastic programming offers lead to the best tradeoff profit versus risk. -- Abstract: As wind power technology matures and reaches break-even cost, wind producers find it increasingly attractive to participate in pool markets instead of being paid feed-in tariffs. The key issue is then how a wind producer should offer in the pool markets to achieve maximum profit while controlling the variability of such profit. This paper compares two families of offering strategies based, respectively, on a naive use of wind production forecasts and on stochastic programming models. These strategies are compared through a comprehensive out-of-sample chronological analysis based on real-world data. A number of relevant conclusions are then duly drawn.

  6. Decision support for organ offers in liver transplantation.

    Science.gov (United States)

    Volk, Michael L; Goodrich, Nathan; Lai, Jennifer C; Sonnenday, Christopher; Shedden, Kerby

    2015-06-01

    Organ offers in liver transplantation are high-risk medical decisions with a low certainty of whether a better liver offer will come along before death. We hypothesized that decision support could improve the decision to accept or decline. With data from the Scientific Registry of Transplant Recipients, survival models were constructed for 42,857 waiting-list patients and 28,653 posttransplant patients from 2002 to 2008. Daily covariate-adjusted survival probabilities from these 2 models were combined into a 5-year area under the curve to create an individualized prediction of whether an organ offer should be accepted for a given patient. Among 650,832 organ offers from 2008 to 2013, patient survival was compared by whether the clinical decision was concordant or discordant with model predictions. The acceptance benefit (AB)--the predicted gain or loss of life by accepting a given organ versus waiting for the next organ--ranged from 3 to -22 years (harm) and varied geographically; for example, the average benefit of accepting a donation after cardiac death organ ranged from 0.47 to -0.71 years by donation service area. Among organ offers, even when AB was >1 year, the offer was only accepted 10% of the time. Patient survival from the time of the organ offer was better if the model recommendations and the clinical decision were concordant: for offers with AB > 0, the 3-year survival was 80% if the offer was accepted and 66% if it was declined (P decision support may improve patient survival in liver transplantation. © 2015 American Association for the Study of Liver Diseases.

  7. How do underwriters value initial public offerings? An empirical analysis of the french IPO market

    NARCIS (Netherlands)

    P.G.J. Roosenboom (Peter)

    2007-01-01

    textabstractThis paper investigates how French underwriters value the stocks of companies they bring public. Underwriters often use several valuation methods to determine their fair value estimate of the initial public offering (IPO) firm's equity. We investigate five of these valuation methods:

  8. New Therapies Offer Valuable Options for Patients with Melanoma

    Science.gov (United States)

    Two phase III clinical trials of new therapies for patients with metastatic melanoma presented in June at the 2011 ASCO conference confirmed that vemurafenib and ipilimumab (Yervoy™) offer valuable new options for the disease.

  9. FORUM Obstetric risk avoidance: Will anyone be offering obstetrics ...

    African Journals Online (AJOL)

    performing deliveries in private practice by the end of the decade?' If the answer to the ... Insurance companies, although offering an insurance product, also ... deliver in provincial facilities, shifting the workload and liability to the state.

  10. French scientists offered time to set up companies

    CERN Document Server

    Butler, D

    1999-01-01

    The French minister of national education, research and technology announced that French researchers working for public research institutes and universities are to be offered up to six years sabbatical leave to set up their own companies (11 para)

  11. Managerial segmentation of service offerings in work commuting.

    Science.gov (United States)

    2015-03-01

    Methodology to efficiently segment markets for public transportation offerings has been introduced and exemplified in an : application to an urban travel corridor in which high tech companies predominate. The principal objective has been to introduce...

  12. Quality assurance programs from laboratories offering radiological protection services

    International Nuclear Information System (INIS)

    Marrero Garcia, M.; Prendes Alonso, M.; Jova Sed, L.; Morales Monzon, J.A.

    1998-01-01

    The implementation of an adequate program for quality assurance in institutions servicing radiological protection programs will become an additional tool to achieve security targets included in that program. All scientific and technical services offered by CPHR employ quality assurance systems

  13. Mental Health Providers: Credentials, Services Offered and What to Expect

    Science.gov (United States)

    ... and specific services they offer Treatment approaches and philosophy Which insurance providers they work with Office hours, ... trademarks of Mayo Foundation for Medical Education and Research. © 1998-2018 Mayo Foundation for Medical Education and ...

  14. Brand positioning through banking services' offer: Serbian perspective

    OpenAIRE

    Novčić Branka; Damnjanović Vesna; Filipović Vinka

    2012-01-01

    The subject of this paper relates to the determination of interdependent relationship of the key elements necessary for the positioning of brands in the banking market in Serbia. The main goal of this paper is to analyze the way in which managers of banks in Serbia perceived brand positioning of banks in which they work, and the value of the customer service offer - corporate clients. Research focuses on identifying and comparing the dependent relationships between the key elements of offers'...

  15. The effects of affiliations on the initial public offering pricing

    OpenAIRE

    Geranio, Manuela; Mazzoli, Camilla; Palmucci, Fabrizio

    2017-01-01

    This paper studies the impact of affiliations between lead managers, venture capitalists, and institutional investors on the Initial Public Offering (IPO) pricing. Using a sample of 1996 US IPOs issued between 1997 and 2010, we find that affiliations strongly and positively affect the offer price by improving the information production process. We also show that the underpricing is affected by affiliations because of conflicts of interest that exist between the players: when an institutional ...

  16. Availability of websites offering to sell psilocybin spores and psilocybin.

    Science.gov (United States)

    Lott, Jason P; Marlowe, Douglas B; Forman, Robert F

    2009-09-01

    This study assesses the availability of websites offering to sell psilocybin spores and psilocybin, a powerful hallucinogen contained in Psilocybe mushrooms. Over a 25-month period beginning in March 2003, eight searches were conducted in Google using the term "psilocybin spores." In each search the first 100 nonsponsored links obtained were scored by two independent raters according to standardized criteria to determine whether they offered to sell psilocybin or psilocybin spores. No attempts were made to procure the products offered for sale in order to ascertain whether the marketed psilocybin was in fact "genuine" or "counterfeit." Of the 800 links examined, 58% led to websites offering to sell psilocybin spores. Additionally, evidence that whole Psilocybe mushrooms are offered for sale online was obtained. Psilocybin and psilocybin spores were found to be widely available for sale over the Internet. Online purchase of psilocybin may facilitate illicit use of this potent psychoactive substance. Additional studies are needed to assess whether websites offering to sell psilocybin and psilocybin spores actually deliver their products as advertised.

  17. Which offers more scope to suppress river phytoplankton blooms: reducing nutrient pollution or riparian shading?

    Science.gov (United States)

    Hutchins, M G; Johnson, A C; Deflandre-Vlandas, A; Comber, S; Posen, P; Boorman, D

    2010-10-01

    River flow and quality data, including chlorophyll-a as a surrogate for river phytoplankton biomass, were collated for the River Ouse catchment in NE England, which according to established criteria is a largely unpolluted network. Against these data, a daily river quality model (QUESTOR) was setup and successfully tested. Following a review, a river quality classification scheme based on phytoplankton biomass was proposed. Based on climate change predictions the model indicated that a shift from present day oligotrophic/mesotrophic conditions to a mesotrophic/eutrophic system could occur by 2080. Management options were evaluated to mitigate against this predicted decline in quality. Reducing nutrient pollution was found to be less effective at suppressing phytoplankton growth than the less costly option of establishing riparian shading. In the Swale tributary, ongoing efforts to reduce phosphorus loads in sewage treatment works will only reduce peak (95th percentile) phytoplankton by 11%, whereas a reduction of 44% is possible if riparian tree cover is also implemented. Likewise, in the Ure, whilst reducing nitrate loads by curtailing agriculture in the headwaters may bring about a 10% reduction, riparian shading would instead reduce levels by 47%. Such modelling studies are somewhat limited by insufficient field data but offer a potentially very valuable tool to assess the most cost-effective methods of tackling effects of eutrophication. Copyright 2010 Elsevier B.V. All rights reserved.

  18. Vibrating crystals as possible neutron monochromators

    International Nuclear Information System (INIS)

    Stoica, A.D.; Popovici, M.

    1983-09-01

    The Bragg reflection of neutrons of vibratinq perfect crystals is considered. The additional possibilities offered by the Doppler effect for shaping neutron beams in the k-space are discussed. A simple model for computing the vibrating crystal reflectivity is proposed. (author)

  19. Possibility Fuzzy Soft Set

    Directory of Open Access Journals (Sweden)

    Shawkat Alkhazaleh

    2011-01-01

    Full Text Available We introduce the concept of possibility fuzzy soft set and its operation and study some of its properties. We give applications of this theory in solving a decision-making problem. We also introduce a similarity measure of two possibility fuzzy soft sets and discuss their application in a medical diagnosis problem.

  20. Telemedicine. Possibilities and perspectives

    International Nuclear Information System (INIS)

    Lenzen, H.; Meier, N.; Bick, U.

    1997-01-01

    Radiological teaching files on the Interent suffer from certain restrictions such as limited user interactivity. The Internet teaching project CONRAD (computer online network for radiological didactics) circumvents these restrictions by using a new database structure that also reflects the development of a diagnosis over time. The cases are presented in the Internet with different HTML-based teaching programs. To support interactivity, CONRAD offers the building of online learning groups over the Internet. (orig.) [de

  1. Investor Reaction to Mandatory Offers on the Warsaw Stock Exchange

    Directory of Open Access Journals (Sweden)

    Szymon Okoń

    2012-06-01

    Full Text Available The following paper aims to assess investor reaction to mandatory offers on the Warsaw Stock Exchange, which is important because knowledge about these reactions can be used to make better investment decisions. This paper highlights the importance of procedure in making a mandatory offer and its grounds in the Polish legal system. Additionally, it presents empirical research on the reactions of investors to mandatory offers on the Warsaw Stock Exchange. It has been provided that mandatory offers have a significant impact on the price of a company’s shares listed on the Warsaw Stock Exchange. Knowledge about the reactions of investors to a mandatory offer may be used when selecting securities for an investment portfolio. The findings may provide guidance in deciding whether to begin or end investment in the company, both for individual and institutional investors. The event study methodology approach used in the paper is regarded as valuable and can be the basis for further research in other areas of the capital market research, especially in the context of information efficiency.

  2. BUSINESS NEEDS AND GRADUATE BUSINESS SCHOOL OFFERINGS IN MARKETING.

    Science.gov (United States)

    Thams, Meg; Glueck, Deborah

    2007-04-01

    The purpose of this study was to determine if a gap exists in the skill and knowledge businesses require of marketing employees and what the Association to Advance Collegiate Schools of Business (AACSB) accredited schools actually provide. In this quantitative study, two set of data were collected and compared, and a gap analysis conducted. A questionnaire was used to obtain data from members of the Business Marketing Association (BMA) regarding course preferences that would best prepare students for positions in marketing. Records analysis was then undertaken of the marketing course offerings of AACSB accredited MBA programs offering an emphasis in Marketing. Gap analysis was conducted by applying a test of difference to the results of the two data collection efforts. Results of the study suggest that some misalignment between school offerings and business needs exists.

  3. BUSINESS NEEDS AND GRADUATE BUSINESS SCHOOL OFFERINGS IN MARKETING

    Science.gov (United States)

    Thams, Meg; Glueck, Deborah

    2010-01-01

    The purpose of this study was to determine if a gap exists in the skill and knowledge businesses require of marketing employees and what the Association to Advance Collegiate Schools of Business (AACSB) accredited schools actually provide. In this quantitative study, two set of data were collected and compared, and a gap analysis conducted. A questionnaire was used to obtain data from members of the Business Marketing Association (BMA) regarding course preferences that would best prepare students for positions in marketing. Records analysis was then undertaken of the marketing course offerings of AACSB accredited MBA programs offering an emphasis in Marketing. Gap analysis was conducted by applying a test of difference to the results of the two data collection efforts. Results of the study suggest that some misalignment between school offerings and business needs exists. PMID:26726319

  4. The voluntary safeguards offer of the United States

    International Nuclear Information System (INIS)

    Houck, F.S.

    1985-01-01

    During negotiations of the Treaty on the Non-Proliferation of Nuclear Weapons (NPT) concerns were expressed by non-nuclear-weapon States that their acceptance of Agency safeguards would put them at a disadvantage vis-a-vis the nuclear-weapon States. To allay these concerns, the United States and the United Kingdom in December 1967 made voluntary offers to accept Agency safeguards on their peaceful nuclear activities. Subsequently, France made a voluntary offer, the safeguards agreement for which was approved by the IAEA Board of Governors in February 1978, with a view to encouraging acceptance of Agency safeguards by additional States. More recently, in February 1985 the Board approved the safeguards agreement for the voluntary offer of the USSR, made inter alia to encourage further acceptance of Agency safeguards. These safeguards agreements with nuclear-weapon-States have two important features in common: Namely, they result from voluntary offers to accept safeguards rather than from multilateral or bilateral undertakings, and they give the Agency the right but generally not an obligation to apply its safeguards. The agreements differ in certain respects, the most noteworthy of which is the scope of the nuclear activities covered by each offer. The agreements of the United States and United Kingdom are the broadest, covering all peaceful nuclear activities in each country. The safeguards agreement for the US voluntary offer has been in force since December 1980. Now is an appropriate time to review the experience with the agreement's implementation during its first four years, as well as its history and salient features

  5. Extracting product offers from e-shop websites

    OpenAIRE

    Horch, Andrea; Kett, Holger; Weisbecker, Anette

    2016-01-01

    On-line retailers as well as e-shoppers are very interested in gathering product records from the Web in order to compare products and prices. The consumers compare products and prices to find the best price for a specific product or they want to identify alternatives for a product whereas the on-line retailers need to compare their offers with those of their competitors for being able to remain competitive. As there is a huge number and vast array of product offers in the Web the product dat...

  6. STUDY REGARDING OFFER ON DISTANCE ACCOUNTING EDUCATION IN ROMANIA

    Directory of Open Access Journals (Sweden)

    TEIUŞAN SORIN-CIPRIAN

    2015-12-01

    Full Text Available The national study programme forms of organization are: daily attendance studies, low attendance studies, and distance education. The objective of this study is to research the distance accounting education. The paper examines the offer for distance education in accounting. We identified all public and private universities who provide a study program on distance accounting education. By analysing the maximum number of students that can be schooled in distance learning and the tuition fee, comparative with full-time program, we intend to offer information to those interested in the accounting education domain.

  7. Customer expectations and current offers from food trucks in Helsinki

    OpenAIRE

    Nguyen, An

    2017-01-01

    The aim of this thesis is to determine whether there is a gap between what customers expect and what the food trucks in Helsinki offers in term of diversity of products, price, time and location of service. Do the current offers match with what customers would like to have? The food truck concept has a long history and since 2008 became an international phenomenon. However, it is still relatively young in Helsinki. There are concerted efforts from different parties included the city’s au...

  8. Development of Sremski Karlovci wine tourism and integration in the regional tourism offer

    Directory of Open Access Journals (Sweden)

    Škrbić Iva

    2015-01-01

    Full Text Available Integration and globalisation processes are unavoidable in all fields of business economy, including tourism. Potential success of wine tourism in Sremski Karlovci should be based on diversification of products that entails an influx of tourism and winemaking into other fields of economy. During the development of wine tourism offer, it would be advisable to consult the experiences of the developed wine region and to use their models, which is done in this paper, via benchmark analysis of offers of Sremski Karlovci wineries with those of the Ontario region (Canada and the place of Villány (Hungary. The goal of this paper is to establish the possible directions of development of the integral product of wine tourism of Sremski Karlovci as a prerequisite for integration into the regional tourism offer. The research indicates that wine tourism offer of Sremski Karlovci is underdeveloped. A large number of product diversification fields are not recognised. The future development of Sremski Karlovci wineries should be based on conquering of those very fields. Such a tourism product could more easily be integrated into the regional wine tourism offer.

  9. On possibility of using E, H - crossed fields and gas-dynamic flowing of argon in the processes of degassing by the method of ion-stimulated desorption of residual gas in the KUTI-20

    International Nuclear Information System (INIS)

    Sharapov, V.E.

    1985-01-01

    In the project considered if the possibility to use the degassing of an adhezatior chamber inner walls, using the method of ion-stimulated desorption (ISD) of residual gas in the glow discharge is considered. It is suggested that the experiment should be realized using the model or the KUTI (PKUTI) prototype to decrease operation pressure to p -7 Pa (2x10 -9 Tor) at the expense of introduction of the technology described and certain modifications in the processes of leak-in and pumping. The use of crossed E,H-fields and gasodynamic regime of argon flow in the process of preliminary degassing of the adhezator chamber by the glow discharge is the main idea of the project

  10. Expensive blood safety initiatives may offer less benefit than we think

    DEFF Research Database (Denmark)

    Kamper-Jørgensen, Mads; Hjalgrim, Henrik; Edgren, Gustaf

    2010-01-01

    Various blood safety initiatives have ensured a historically low risk of infection transmission through blood transfusion. Although further prevention of infection transmission is possible through, for example, nucleic acid testing and future introduction of pathogen inactivation, such initiative...... are very costly in relation to the benefit they offer. Although estimation of the cost-effectiveness requires detailed information about the survival of transfusion recipients, previous cost-effectiveness analyses have relied on incorrect survival assumptions....

  11. New Channels, New Possibilities

    DEFF Research Database (Denmark)

    Pieterson, Willem; Ebbers, Wolfgang; Østergaard Madsen, Christian

    2017-01-01

    In this contribution we discuss the characteristics of what we call the fourth generation of public sector service channels: social robots. Based on a review of relevant literature we discuss their characteristics and place into multi-channel models of service delivery. We argue that social robots......-channel models of service delivery. This is especially relevant given the current lack of evaluations of such models, the broad range of channels available, and their different stages of deployment at governments around the world. Nevertheless, social robots offer an potentially very relevant addition...

  12. PREDICTION OF DEMAND FOR PRIMARY BOND OFFERINGS USING ARTIFICIAL NEURAL NETWORKS

    Directory of Open Access Journals (Sweden)

    Michal Tkac

    2014-12-01

    Full Text Available Purpose: Primary bond markets represent an interesting investment opportunity not only for banks, insurance companies, and other institutional investors, but also for individuals looking for capital gains. Since offered securities vary in terms of their rating, industrial classification, coupon, or maturity, demand of buyers for particular offerings often overcomes issued volume and price of given bond on secondary market consequently rises. Investors might be regarded as consumers purchasing required service according to their specific preferences at desired price. This paper aims at analysis of demand for bonds on primary market using artificial neural networks.Design/methodology: We design a multilayered feedforward neural network trained by Levenberg-Marquardt algorithm in order to estimate demand for individual bonds based on parameters of particular offerings. Outcomes obtained by artificial neural network are compared with conventional econometric methods.Findings: Our results indicate that artificial neural network significantly outperformed standard econometric techniques and on examined sample of primary bond offerings achieved considerably better performance in terms of prediction accuracy and mean squared error.Originality: We show that proposed neural network is able to successfully predict demand for primary obligation offerings based on their specifications. Moreover, we identify relevant parameters of issues which are able to considerably affect total demand for given security.  Our findings might not only help investors to detect marketable securities, but also enable issuing entities to increase demand for their bonds in order to decrease their offering price. 

  13. 20 CFR 655.1308 - Offered wage rate.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Offered wage rate. 655.1308 Section 655.1308 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR TEMPORARY EMPLOYMENT OF... require exercising judgment and may coordinate the activities of other staff. They may have supervisory...

  14. A Roadmap for Offering MOOC from an LMIC Institution

    Science.gov (United States)

    Abidi, Syed Hani; Pasha, Aamna; Moran, Greg; Ali, Syed

    2017-01-01

    MOOCs are massive open online courses that are globally accessible, free of charge. Given their cost-free and open accessibility, it is surprising that only a few institutions have offered MOOCs from low- and middle-income countries (LMICs). Pakistan recently made this short list of LMICs as the first two MOOCs were launched from the country, in…

  15. Ontario's standard offer programs: moving toward a cleaner energy future

    International Nuclear Information System (INIS)

    Shervill, P.

    2006-01-01

    The Ontario Standard Offer Program is designed to ensure reliable, long-term electricity supply for Ontario. The functional areas of the program are planning, conservation and supply sector development. The long-term plan is to create a self-sustaining electricity market in Ontario with 2700 MW renewable sources by 2010 including wind, waterpower, solar photovoltaic (PV) and biomass

  16. 40 CFR 303.32 - Pre-payment offers.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 27 2010-07-01 2010-07-01 false Pre-payment offers. 303.32 Section 303.32 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS CITIZEN AWARDS FOR INFORMATION ON CRIMINAL VIOLATIONS UNDER...

  17. 44 CFR 19.415 - Access to course offerings.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Access to course offerings. 19.415 Section 19.415 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY... in wrestling, boxing, rugby, ice hockey, football, basketball, and other sports the purpose or major...

  18. Conference Offers Girls Opportunity to Expand Career Horizons

    Science.gov (United States)

    Offers Girls Opportunity to Expand Career Horizons For more information contact: e:mail: Public Affairs Golden, Colo., Feb. 11, 1997 -- Expanding Your Horizons, a conference for girls grades 6 - 9 and Employed Women, Girls Incorporated of Metro Denver, King Soopers, McDonalds, the TCI Adult Program and the

  19. Offering-level strategy formulation in health service organizations.

    Science.gov (United States)

    Pointer, D D

    1990-01-01

    One of six different strategies must be selected for a health service offering to provide consumers with distinctive value and achieve sustainable competitive advantage in a market or market segment. Decisions must be made regarding objectives sought, market segmentation, market scope, and the customer-value proposition that will be pursued.

  20. 47 CFR 54.407 - Reimbursement for offering Lifeline.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Reimbursement for offering Lifeline. 54.407... (CONTINUED) UNIVERSAL SERVICE Universal Service Support for Low-Income Consumers § 54.407 Reimbursement for... carrier may receive universal service support reimbursement for each qualifying low-income consumer served...

  1. 20 CFR 655.202 - Contents of job offers.

    Science.gov (United States)

    2010-04-01

    ... of hours worked by the worker is less than the number offered in accordance with the guarantee, the... will not adversely affect the wages and working conditions of similarly employed U.S. workers, each... working conditions are required by the provisions of paragraph (a) of this section, the OFLC Administrator...

  2. Review of Full Spectrum of Services offered at Special Libraries

    Directory of Open Access Journals (Sweden)

    Fatemeh Assian

    2009-12-01

    Full Text Available   Special libraries fill a very important role in providing services to corporate users. The necessity to identify and promote the full spectrum of services offered by these type of libraries is felt more than ever. The present paper attempts to describe these services by reviewing the literature published in this respect.

  3. Special offer from the Carlson Wagonlit Travel agency

    CERN Multimedia

    Carlson Wagonlit Travel

    2011-01-01

    Special offer 4th – 28th April Reduced CWT service fee for any new reservation of a holiday package (flight + hotel/apartment). Reserve for 1, 2, 3 or more travelers – pay the service fee for one person only. Valid at your CWT CERN agency.

  4. Epoxy adhesives offer broad choice for challenging applications

    CERN Multimedia

    Stevens, P

    2006-01-01

    "While they do not offer quite the same fascination as the "instant" adhesives that deliver great strenght from a single drop, exposy adhesives are now available with a remarkably wide range of material properties. As such, grades can be specified for use on almost any material type in most industries"

  5. 31 CFR 352.0 - Offering of bonds.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Offering of bonds. 352.0 Section 352.0 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE... terminate at the close of business on August 31, 2004. [69 FR 40318, July 2, 2004] ...

  6. An Evaluation of Guidance and Counselling Services Offered to ...

    African Journals Online (AJOL)

    This paper sought to evaluate the guidance and counselling services offered to students in Gwanda urban and peri-urban secondary schools. Guidance and counselling is regarded as a programme and service in the education system, providing advice with regards to students' education, career planning, social issues or ...

  7. 28 CFR 54.415 - Access to course offerings.

    Science.gov (United States)

    2010-07-01

    ..., music, and adult education courses. (b)(1) With respect to classes and activities in physical education... SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities Prohibited § 54.415 Access to course offerings. (a) A...

  8. 41 CFR 101-4.415 - Access to course offerings.

    Science.gov (United States)

    2010-07-01

    ..., music, and adult education courses. (b)(1) With respect to classes and activities in physical education... EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities Prohibited § 101-4.415 Access to course offerings. (a) A...

  9. Method

    Directory of Open Access Journals (Sweden)

    Ling Fiona W.M.

    2017-01-01

    Full Text Available Rapid prototyping of microchannel gain lots of attention from researchers along with the rapid development of microfluidic technology. The conventional methods carried few disadvantages such as high cost, time consuming, required high operating pressure and temperature and involve expertise in operating the equipment. In this work, new method adapting xurography method is introduced to replace the conventional method of fabrication of microchannels. The novelty in this study is replacing the adhesion film with clear plastic film which was used to cut the design of the microchannel as the material is more suitable for fabricating more complex microchannel design. The microchannel was then mold using polymethyldisiloxane (PDMS and bonded with a clean glass to produce a close microchannel. The microchannel produced had a clean edge indicating good master mold was produced using the cutting plotter and the bonding between the PDMS and glass was good where no leakage was observed. The materials used in this method is cheap and the total time consumed is less than 5 hours where this method is suitable for rapid prototyping of microchannel.

  10. Offer as a creative foundation of direct marketing

    Directory of Open Access Journals (Sweden)

    Kocić Milan

    2010-01-01

    Full Text Available Investments into communications mix are specific because besides significant financial resources it also involves creative marketing ideas that are a result of imagination and experience. However, the application of direct marketing communication mix is like 'a cave on iceberg'. The visible aspect presented through promotional content is only a small part of the whole process including experts from different fields. The process of creation a new communication mix of direct marketing must fully use all the challenges posed by sophisticated technology. Direct marketing depicted by new technology (cable television, telemarketing and the Internet can substantially increase the competitive advantage of enterprises in attracting their customer's attention and creating their loyalty as well. The companies use the mentioned media more frequently in order to create such offers that will lead towards strengthening loyalty of the existing customers, while simultaneously attracting those customers who were previously making purchases with our direct competitors. Hence, an offer as a creatively designed marketing vehicle proposes a number of potential benefits to a client. However, the client will be able to claim those benefits only in the case when a customer takes action as suggested by a communicated message. Basically, those are 'the rules of the game' that regulate relationship between company and client in direct marketing. Creating offers which guide the process of direct marketing is in the domain of customer relations management. Without an attractive offer, consumers will not create any type of measurable response to a company and therefore relations with clients would never emerge. On the other hand, if a company fails to continuously follow client's needs and wants, those engaged in direct sales will not be able to create adequate offers that would satisfy clients and motivate them to repeat purchases. .

  11. Who are the adolescents saying "No" to cannabis offers.

    Science.gov (United States)

    Burdzovic Andreas, Jasmina; Pape, Hilde; Bretteville-Jensen, Anne Line

    2016-06-01

    Adolescents who refuse direct cannabis offers and remain non-users represent a potentially very informative, yet surprisingly understudied group. We examined a range of risk and protective factors putatively associated with this poorly understood "cannabis-resilient" profile. Paper-and-pencil questionnaires assessing substance use, peer and family relations, and behavioral and personality characteristics were completed by 19,303 middle- and high-school students from 82 schools in Norway (response rate 84%) The lifetime prevalence of cannabis use was 7.6%. Another 10.4% reported no use of the drug despite having received recent cannabis offers. Results from the multinomial logistic regression revealed a set of characteristics differentiating adolescents who resisted such offers from those who: (a) neither received the offers nor used, and, more importantly, (b) used the drug. Specifically, parent-child relationship quality, negative drug-related beliefs, absence of close relationships with cannabis-users, low delinquency, no regular tobacco use, and infrequent alcohol intoxication were all associated with increased odds of being in the cannabis-resilient vs. cannabis-user group. This pattern of results was comparable across middle- and high-school cohorts, but the parent-child relationship quality and delinquency were significantly associated with cannabis-resilient vs. cannabis-use outcome only among younger and older adolescents, respectively. Among other low-risk characteristics, better relationships with parents and beliefs that drug use is problematic were associated with adolescents' refusals to accept cannabis offers. These results may have implications for novel preventive strategies targeting cannabis-exposed adolescents. Copyright © 2016. Published by Elsevier Ireland Ltd.

  12. Stock Price Performance Following Equity Offerings at Oslo Stock Exchange: Is Investing in SEO Companies Hazardous to Your Wealth?

    OpenAIRE

    Grieg, Benedicte Willumsen

    2012-01-01

    I examine the stock price performance following a seasoned equity offering at Oslo Stock Exchange. Through an empirical analysis I find that the existence of a negative announcement effect associated with issuing seasoned equity, as well as a long-run underperformance, is also applicable in the Norwegian market. The level of asymmetry can to a large extent explain the price drop and varies with characteristics like sector, offering size, floatation method, and pre-offer performance. The long-...

  13. ANALISIS NILAI WAJAR SAHAM PUBLIK DALAM TENDER OFFER (Studi Kasus PT Bentoel Internasional Investama Tbk

    Directory of Open Access Journals (Sweden)

    Herlitah

    2014-08-01

    Full Text Available The purpose of this research is to analyze Fair Value of the stock price of PT Bentoel Internasional Investama Tbk. for tender offer after the acquisition from British American Tobacco. The Discounted Cash Flow/DCF Method of the Income Approach used for calculation within the Free Cash Flow to The Equity/FCFE Model.

  14. "What Have the Humanities to Offer 21st-Century Europe?": Reflections of a Note Taker

    Science.gov (United States)

    Parker, Jan

    2008-01-01

    The Humanities have much to offer 21st-century Europe, in terms of both method and issues which may complement and correct those of Science and Social Science. These include, for instance, humanities' generation of plural narratives and plural explanations, of attention to singularity and complexity, and to others' sensibilities and ways of…

  15. method

    Directory of Open Access Journals (Sweden)

    L. M. Kimball

    2002-01-01

    Full Text Available This paper presents an interior point algorithm to solve the multiperiod hydrothermal economic dispatch (HTED. The multiperiod HTED is a large scale nonlinear programming problem. Various optimization methods have been applied to the multiperiod HTED, but most neglect important network characteristics or require decomposition into thermal and hydro subproblems. The algorithm described here exploits the special bordered block diagonal structure and sparsity of the Newton system for the first order necessary conditions to result in a fast efficient algorithm that can account for all network aspects. Applying this new algorithm challenges a conventional method for the use of available hydro resources known as the peak shaving heuristic.

  16. Cost-effectiveness of primary offer of IVF vs. primary offer of IUI followed by IVF (for IUI failures in couples with unexplained or mild male factor subfertility

    Directory of Open Access Journals (Sweden)

    Lyratzopoulos Georgios

    2006-06-01

    Full Text Available Abstract Background In unexplained and mild male factor subfertility, both intrauterine insemination (IUI and in-vitro fertilisation (IVF are indicated as first line treatments. Because the success rate of IUI is low, many couples failing IUI subsequently require IVF treatment. In practice, it is therefore important to examine the comparative outcomes (live birth-producing pregnancy, costs, and cost-effectiveness of primary offer of IVF, compared with primary offer of IUI followed by IVF for couples failing IUI. Methods Mathematical modelling was used to estimate comparative clinical and cost effectiveness of either primary offer of one full IVF cycle (including frozen cycles when applicable or "IUI + IVF" (defined as primary IUI followed by IVF for IUI failures to a hypothetical cohort of subfertile couples who are eligible for both treatment strategies. Data used in calculations were derived from the published peer-reviewed literature as well as activity data of local infertility units. Results Cost-effectiveness ratios for IVF, "unstimulated-IUI (U-IUI + IVF", and "stimulated IUI (S-IUI + IVF" were £12,600, £13,100 and £15,100 per live birth-producing pregnancy respectively. For a hypothetical cohort of 100 couples with unexplained or mild male factor subfertility, compared with primary offer of IVF, 6 cycles of "U-IUI + IVF" or of "S-IUI + IVF" would cost an additional £174,200 and £438,000, representing an opportunity cost of 54 and 136 additional IVF cycles and 14 to 35 live birth-producing pregnancies respectively. Conclusion For couples with unexplained and mild male factor subfertility, primary offer of a full IVF cycle is less costly and more cost-effective than providing IUI (of any modality followed by IVF.

  17. Another Theory is Possible

    DEFF Research Database (Denmark)

    Manners, Ian James

    2016-01-01

    The article argues that dissident voices which attempt to theorise Europe differently and advocate another European trajectory have been largely excluded and left unheard in mainstream discussions over the past decade of scholarship and analysis. Dissident voices in European Union studies are tho...... theory, is possible – indeed, probable....

  18. Neural substrates underlying the tendency to accept anger-infused ultimatum offers during dynamic social interactions.

    Science.gov (United States)

    Gilam, Gadi; Lin, Tamar; Raz, Gal; Azrielant, Shir; Fruchter, Eyal; Ariely, Dan; Hendler, Talma

    2015-10-15

    In managing our way through interpersonal conflict, anger might be crucial in determining whether the dispute escalates to aggressive behaviors or resolves cooperatively. The Ultimatum Game (UG) is a social decision-making paradigm that provides a framework for studying interpersonal conflict over division of monetary resources. Unfair monetary UG-offers elicit anger and while accepting them engages regulatory processes, rejecting them is regarded as an aggressive retribution. Ventro-medial prefrontal-cortex (vmPFC) activity has been shown to relate to idiosyncratic tendencies in accepting unfair offers possibly through its role in emotion regulation. Nevertheless, standard UG paradigms lack fundamental aspects of real-life social interactions in which one reacts to other people in a response contingent fashion. To uncover the neural substrates underlying the tendency to accept anger-infused ultimatum offers during dynamic social interactions, we incorporated on-line verbal negotiations with an obnoxious partner in a repeated-UG during fMRI scanning. We hypothesized that vmPFC activity will differentiate between individuals with high or low monetary gains accumulated throughout the game and reflect a divergence in the associated emotional experience. We found that as individuals gained more money, they reported less anger but also more positive feelings and had slower sympathetic response. In addition, high-gain individuals had increased vmPFC activity, but also decreased brainstem activity, which possibly reflected the locus coeruleus. During the more angering unfair offers, these individuals had increased dorsal-posterior Insula (dpI) activity which functionally coupled to the medial-thalamus (mT). Finally, both vmPFC activity and dpI-mT connectivity contributed to increased gain, possibly by modulating the ongoing subjective emotional experience. These ecologically valid findings point towards a neural mechanism that might nurture pro-social interactions by

  19. Characterization of Near-Surface Geology and Possible Voids Using Resistivity and Electromagnetic Methods at the Gran Quivira Unit of Salinas Pueblo Missions National Monument, Central New Mexico, June 2005

    Science.gov (United States)

    Ball, Lyndsay B.; Lucius, Jeffrey E.; Land, Lewis A.; Teeple, Andrew

    2006-01-01

    At the Gran Quivira Unit of Salinas Pueblo Missions National Monument in central New Mexico, a partially excavated pueblo known as Mound 7 has recently become architecturally unstable. Historical National Park Service records indicate both natural caves and artificial tunnels may be present in the area. Knowledge of the local near-surface geology and possible locations of voids would aid in preservation of the ruins. Time-domain and frequency-domain electromagnetic as well as direct-current resistivity methods were used to characterize the electrical structure of the near-surface geology and to identify discrete electrical features that may be associated with voids. Time-domain electromagnetic soundings indicate three major electrical layers; however, correlation of these layers to geologic units was difficult because of the variability of lithologic data from existing test holes. Although resistivity forward modeling was unable to conclusively determine the presence or absence of voids in most cases, the high-resistivity values (greater than 5,000 ohm-meters) in the direct-current resistivity data indicate that voids may exist in the upper 50 meters. Underneath Mound 7, there is a possibility of large voids below a depth of 20 meters, but there is no indication of substantial voids in the upper 20 meters. Gridded lines and profiled inversions of frequency-domain electromagnetic data showed excellent correlation to resistivity features in the upper 5 meters of the direct-current resistivity data. This technique showed potential as a reconnaissance tool for detecting voids in the very near surface.

  20. Loan Products Included in the Offer of Commercial Banks

    Directory of Open Access Journals (Sweden)

    Vasile Dedu

    2009-04-01

    Full Text Available A bank loan is the main form of economical credit. It is for corporate activities – for medium and big companies and for retail activities – for small companies and individuals. The conditions for credit mainly depend on the quality of customers, it means their ability to perform a profitable activity and to be able to pay back the credits. For reasons which are mainly connected to marketing, bank practice has developed a large range of credit names, trying to emphasize some of the parts of the products or to take profit of some competition advantages in relation with customers’ products. We are trying to include the offer of bank loans in a typology which takes into account the law, the bank field rules and the main technical features of the offered products.

  1. Offer and Acceptance under the Russian Civil Code

    Directory of Open Access Journals (Sweden)

    Valery Musin

    2013-01-01

    Full Text Available The article deals with a procedure of entering into a contract under Russian civil law both at the domestic and foreign markets. An offer and an acceptance are considered in the light or relevant provisions of the Russian Civil Codes of 1922, 1964 and that currently effective as compared with rules of the UN Convention on Contracts for the International Sale of Goods 1980 and INIDROIT Principles of International Commercial Contracts 2010.

  2. What does rCBF-SPECT offer in schizophrenia?

    International Nuclear Information System (INIS)

    Syed, G.M.S.; Barrett, J.J.; Toone, B.K.

    1992-01-01

    Schizophrenia is a major psychiatric problem common in the younger population. Structural imaging and findings on autopsy have not yet revealed a specific deficit in these patients. Uncertainty in clinical diagnosis based on a set of signs and symptoms is another drawback in the management of this patient population. Regional cerebral blood flow studies (rCBF) using single photon emission computed tomography (SPECT) offers the opportunity to study the underlying phenomenon and to detect the specific functional deficits in schizophrenia. (Author)

  3. International fuel cycle centres offer large economics and easier financing

    International Nuclear Information System (INIS)

    Smith, D.

    1977-01-01

    The summary report of the IAEA study project on multi-national regional nuclear fuel cycle indicates that for facilities of reasonable size such projects offer very decisive advantages in fuel cycle costs and resource availability over national facilities in general, and more markedly over the other alternative of the open ended, non-recycle fuel route. The economic evaluation of alternative fuel cycle strategies, one of the basic studies summarised in the report, is considered. (author)

  4. High-testosterone men reject low ultimatum game offers

    OpenAIRE

    Burnham, Terence C

    2007-01-01

    The ultimatum game is a simple negotiation with the interesting property that people frequently reject offers of ‘free’ money. These rejections contradict the standard view of economic rationality. This divergence between economic theory and human behaviour is important and has no broadly accepted cause. This study examines the relationship between ultimatum game rejections and testosterone. In a variety of species, testosterone is associated with male seeking dominance. If low ultimatum game...

  5. Offer and acceptance under the Russian Civil Code

    OpenAIRE

    Musin, Valery

    2013-01-01

    The article deals with a procedure of entering into a contract under Russian civil law both at the domestic and foreign markets. An offer and an acceptance are considered in the light or relevant provisions of the Russian Civil Codes of 1922, 1964 and that currently effective as compared with rules of the UN Convention on Contracts for the International Sale of Goods 1980 and INIDROIT Principles of International Commercial Contracts 2010.

  6. What Bulgarian Banks offer via Internet: an Overview

    OpenAIRE

    Bojidar Bojinov

    2003-01-01

    The new information technologies adoption and e-commerce emergence change the role of financial intermediaries in new E-conomy. During the last years, the bank started an expansion to the web – they offer broad range of traditional bank products and services via Internet. The remote banking become one of the main channels for bank services distribution. The Internet expansion of the Bulgarian banks is at its beginning. The showed results are based on the Internet research, which has aimed to ...

  7. What Bulgarian Banks offer via Internet: an Overview (v2)

    OpenAIRE

    Bojidar Bojinov

    2003-01-01

    The new information technologies adoption and e-commerce emergence change the role of financial intermediaries in new E-conomy. During the last years, the bank started an expansion to the web – they offer broad range of traditional bank products and services via Internet. The remote banking become one of the main channels for bank services distribution. The Internet expansion of the Bulgarian banks is at its beginning. The showed results are based on the Internet research, which has aimed to ...

  8. Flexible Consumers Reserving Electricity and Offering Profitable Downward Regulation

    OpenAIRE

    Höning, Nicolas; La Poutré, Han; Strunz, K.

    2012-01-01

    htmlabstractPrevious work on demand response in smart grids considers dynamic real-time prices, but has so far neglected to consider how consumers can also be involved in planning ahead, both for scheduling of consumption and reserving their ability to regulate downward during balancing. This work models a flexible consumer in a novel two-settlement electricity auction. The consumer buys electricity on an ahead market and offers downward regulation on the balancing market. Bidding in two- set...

  9. PRIVATE BANKING AND WEALTH MANAGEMENT SERVICES OFFERED BY BANKS

    OpenAIRE

    IMOLA DRIGĂ; DORINA NIŢĂ; IOAN CUCU

    2009-01-01

    The paper examines the features of private banking business focusing on the substantial growth in private banking over the last decade as commercial banks have targeted upmarket high net worth individuals. The accumulation of wealth has prompted the development of private banking services for high net worth individuals, offering special relationships and investment services. Private banking is about much more than traditional banking services of deposits and loans. It's about providing a one-...

  10. Banks offer SE more than it asked for

    International Nuclear Information System (INIS)

    Janoska, J.

    2004-01-01

    About a year ago, when new management took over the financial department of Slovenske elektrarne (SE), a.s. the company was in crisis. It faced an acute cash-flow deficit and due loans of over 20 bill. Sk (501.21 mil. Eur). SE could not provide adequate guarantees for the required loans and without state guarantees it was virtually impossible or too expensive to obtain additional loans. But last week the situation changed for the better. Despite the fact that due to the restructuring of SE's loan portfolio, the company will pay the banks 3 bill. Sk (75.18 mil. Eur) less interest over the next three years than under the original arrangements, even the bakers seemed satisfied. A loan portfolio full of non-standard agreements signed with about 30 banks had previously prevented decisions regarding the structure of the company's assets and liabilities.The cabinet refused to admit that SE was in crisis and offered SE for sale, although it could not be privatised due to its debt structure and the fact that it was close to default. Despite this unfavourable situation, company economists decided to make an offensive move -in cooperation with a small group of banks they converted the tens of company loan agreements into a new loan package that will be simpler, cheaper, and with longer maturity periods, which will not require state guarantees. SE managed to restructure debts with a total value of 550 mil. Eur and until these transactions are completed the banks offered SE a bridge loan of 110 mil. Eur. The transaction related to a syndicated loan of 350 mil. Eur which was concluded in April. Eurobonds with a total value of 200 mil. Eur were issued two months later. The banks offered the company more than it requested. Demand for the Eurobond issue exceeded the 200 mil. Eur of bonds on offer. (author)

  11. Restaurant challenge offers healthful meal options and builds diabetes awareness.

    Science.gov (United States)

    Blair, Angela M; Drass, Janice A; Stone, Marylou; Rhoades, Deborah; Baldwin, Susan A; Russ, Kelsey M

    2011-01-01

    The Frederick Restaurant Challenge is an innovative project based on a collaborative effort among community organizations and partners designed to offer delicious healthful meal options at local restaurants during the month of November for American Diabetes Month. Local restaurants were challenged to participate and submitted recipes for healthful meals to the Frederick County Diabetes Coalition for review by registered dietitians. Diners voted on meals to determine the challenge winner(s), and were eligible to win prizes as well. Publicity prior to and during the month was effective in creating positive news about healthful meals when eating out, raised awareness about diabetes, and provided restaurants with desirable advertising opportunities. Feedback from restaurants and diners was overwhelmingly positive. The purpose of this article is to describe this successful low-budget project to encourage its replication in local communities. The Frederick Restaurant Challenge proved to be a very successful, innovative, low-budget project that met its intended goals: to develop healthful meal options for people with diabetes (or for anyone wishing to eat healthier); to demonstrate that healthful food can taste delicious; and to encourage restaurants to continue offering healthful options on their menus beyond the challenge month. Community interventions such as the Frederick Restaurant Challenge offer unique and important strategies for affecting change and raising awareness not only for people with diabetes but also for the entire community.

  12. Exploiting the possibilities of simulators for driver training

    NARCIS (Netherlands)

    De Groot, S.

    2013-01-01

    Training in a simulator offers potential advantages compared to training in a non-simulated environment. Generally it is cheaper, safer, there is more control over the environment, and data collection is less complicated. These potential advantages give simulators the possibility to offer effective

  13. Conditions and development tendencies of touristic offer in Kupres municipality (Bosnia and Herzegovina

    Directory of Open Access Journals (Sweden)

    Ante Šiljeg

    2010-12-01

    Full Text Available Data on tourism represent a basic indicator of the tourist market situation. The very course of the development of a tourist destination, the distribution of tourist resources, as well as the possibility of implementing changes in the tourist offer, all depend upon this data. Strong competition and the increasingly demanding visitors cause the responsible authorities to conduct constant planning and coordination. The term "tourist planning" implies an integral and strategic planning which includes: destination analysis, defining goals, adoption of strategies and programs, planning of land usage, organization of market, defining the desirable economic effect of tourism, and the cooperation of all subjects in the tourist offer. The efficacy of such planning reflects in the tourism indicators which serve as a framework for the assessment of an existing situation and the forming of management guidelines. One of the most relevant indicators of conditions is the opinion of tourists who rate the advantages and the shortcomings of tourist offer in the area which they visit, as well as the opinion of the indigenous population which participates in the creation of the tourist offer.The results of this paper are based upon the conducted survey among the visitors of sport-recreational centres Čajuša and Stožer, and the indigenous population of Kupres municipality. The structural characteristics of the examinees and the values of the actual opinions on the tourist offer have been determined. The perceived discrepancies in the answers from Croatian and domestic visitors indicate a tradition of visiting similar European destinations. The increase in number of tourists by 50% has been achieved in the last several years, primarily thanks to the snowmaking on the ski slopes, but also due to an improved tourist offer (ski courses, ski-lifts, ski kindergarten, snowboard slopes, traditional food, etc.. Although the pre-war tourist capacities still wait for a

  14. Conditions and development tendencies of touristic offer in Kupres municipality (Bosnia and Herzegovina

    Directory of Open Access Journals (Sweden)

    Ante Šiljeg

    2010-01-01

    Full Text Available Data on tourism represent a basic indicator of the tourist market situation. The very course of the development of a tourist destination, the distribution of tourist resources, as well as the possibility of implementing changes in the tourist offer, all depend upon this data. Strong competition and the increasingly demanding visitors cause the responsible authorities to conduct constant planning and coordination. The term "tourist planning" implies an integral and strategic planning which includes: destination analysis, defining goals, adoption of strategies and programs, planning of land usage, organization of market, defining the desirable economic effect of tourism, and the cooperation of all subjects in the tourist offer. The efficacy of such planning reflects in the tourism indicators which serve as a framework for the assessment of an existing situation and the forming of management guidelines. One of the most relevant indicators of conditions is the opinion of tourists who rate the advantages and the shortcomings of tourist offer in the area which they visit, as well as the opinion of the indigenous population which participates in the creation of the tourist offer. The results of this paper are based upon the conducted survey among the visitors of sport-recreational centres Čajuša and Stožer, and the indigenous population of Kupres municipality. The structural characteristics of the examinees and the values of the actual opinions on the tourist offer have been determined. The perceived discrepancies in the answers from Croatian and domestic visitors indicate a tradition of visiting similar European destinations. The increase in number of tourists by 50% has been achieved in the last several years, primarily thanks to the snowmaking on the ski slopes, but also due to an improved tourist offer (ski courses, ski-lifts, ski kindergarten, snowboard slopes, traditional food, etc.. Although the pre-war tourist capacities still wait for a

  15. Offer of authentic food as a condition for gastronomic tourism development

    Directory of Open Access Journals (Sweden)

    Bojana Kalenjuk

    2015-10-01

    Full Text Available By perceiving the food as an important part of the tourism offer in terms of biological needs of tourists, the question arises as to how it can be further exploited to contribute to tourism development. In this regard, food prepared using the local ingredients, according to the old methods of processing and serving, and in an authentic way, can be of interest to the tourists of selective forms of tourism, also known as food tourism, gastronomic tourism and gourmet tourism. The research aims to demonstrate the quality of food offer in the hospitality industry of Vojvodina and examine whether it can meet the requirements of foreign tourists who travel for it. The survey was conducted in 147 catering facilities in Vojvodina offering food and beverages, by means of direct and indirect collecting of written offers, and includes the statistical analysis of 10,923 meals. The aim is to indicate the current state of gastronomic offer and all advantages of authentic food and gastronomic tourism.

  16. Distribution of the educational offer (EOT and formal tourism research structures (FSRT in Ecuador

    Directory of Open Access Journals (Sweden)

    Thiago Duarte Pimentel

    2017-12-01

    Full Text Available The objective of this study was to identify the Ecuadorian educational system, in particular its educational offer in tourism (EOT and to analyze how it is formed and distributed according to different types (universities and non-universities and levels (undergraduate and postgraduate. Specifically, it analyzes its relation with the production of scientific knowledge in tourism, in Ecuador, through the existence of formal research structures (FRST linked to the EOT. The theoretical basis presents the discussion on the sociology of vocational education and training in tourism, as well as on institutionalized structures of knowledge production. Empirically, all the institutions of higher education of the country (IHE were identified according to the data of the Secretaría de Educación Superior, Ciencia, Tecnología e Innovación (SENESCYT, and through the information available on their websites, the ihe in which there was education offer in tourism and linked to this offer the existence of first. The method was previously developed by Pimentel and De Paula (2014. As a result, and conclusion, it has been evidenced that the offer of EOT and FRST is highly asymmetric in the country. Internal discrepancies were also identified for EOT, as the offer of the degree courses predominates, whose thematic area focuses on the subject of economy and management. Therefore, there is a need to seek more balance between EOT, its types, levels and thematic areas.

  17. Representing Uncertainty by Probability and Possibility

    DEFF Research Database (Denmark)

    of uncertain parameters. Monte Carlo simulation is readily used for practical calculations. However, an alternative approach is offered by possibility theory making use of possibility distributions such as intervals and fuzzy intervals. This approach is well suited to represent lack of knowledge or imprecision......Uncertain parameters in modeling are usually represented by probability distributions reflecting either the objective uncertainty of the parameters or the subjective belief held by the model builder. This approach is particularly suited for representing the statistical nature or variance...

  18. The possibilities of laser scattering diagnostics in plasmas

    International Nuclear Information System (INIS)

    Doebele, H.F.

    1974-01-01

    The laser has opened many new possibilities for plasma diagnostics. Intensive monochromatic light sources with higher precision and better time resolution have helped to improve such well-known techniques as interferometry and Schlieren method. At the same time, the range of applicability was extended into the infrared range. Due to the wave length dependence of the plasma diffraction index, the effects increase approximately lambda in interferometry and approximately lambda 2 in the Schlieren methods. The laser also helped to develop entirely new methods such as utilization of the Faraday effect in the electrons of a plasma in a magnetic field which allows the calculation of the product nsub(e) x B from the rotation of the polarization plane of monochromatic light with linear polarization. Here, too, the effect increases approximately lambda 2 , and measurements have been carried out up to FIR (HCN,337 μ). The best diagnostic possibilities are offered by the Thomson scattering diagnostics. Electron and ion temperatures, electron densities, drift velocities, magnetic fields, wave propagation and dissipation can be measured by this method. (orig./AK) [de

  19. Towards the Possible Film

    OpenAIRE

    Dawood, S.

    2014-01-01

    Towards the Possible Film is a study in parallel universes – and the sparks that fly when worlds collide. As much of a projection into a far-off future as a flashback to a long-forgotten past, Dawood’s vivid 20-minute tableau combines the resonance of a mythic fable with the hallucinatory haziness of a waking dream. Emerging from the waves, as if transported from another dimension, two blue-skinned astronauts materialise on a red-rocked shoreline (Sidi Ifni in Southern Morocco). Blinking into...

  20. Future possibilities at ISOLDE

    International Nuclear Information System (INIS)

    Haas, H.

    1991-01-01

    The performance of the ISOLDE facility at CERN is summarized and recently achieved target/ion-source and separator improvements are presented. New ion source principles being tested include multistep laser ionization, bunched surface ionization, and ECR ion source. The prospects for the high-resolution separator ISOLDE-3 are described. The possibilities of a new ISOLDE installation at the PS Booster at CERN are presented together with the planned features of the new facility. Add-on devices to improve the performance that are presently being discussed are an electrostatic sector field, an electron beam ion stripper, and a high voltage platform for energy boosting. (author) 7 refs.; 5 figs

  1. Ball Bearing Stiffnesses- A New Approach Offering Analytical Expressions

    Science.gov (United States)

    Guay, Pascal; Frikha, Ahmed

    2015-09-01

    Space mechanisms use preloaded ball bearings in order to withstand the severe vibrations during launch.The launch strength requires the calculation of the bearing stiffness, but this calculation is complex. Nowadays, there is no analytical expression that gives the stiffness of a bearing. Stiffness is computed using an iterative algorithm such as Newton-Raphson, to solve the nonlinear system of equations.This paper aims at offering a simplified analytical approach, based on the assumption that the contact angle is constant. This approach gives analytical formulas of the stiffness of preloaded ball bearing.

  2. Airports offer unrealized potential for alternative energy production.

    Science.gov (United States)

    DeVault, Travis L; Belant, Jerrold L; Blackwell, Bradley F; Martin, James A; Schmidt, Jason A; Wes Burger, L; Patterson, James W

    2012-03-01

    Scaling up for alternative energy such as solar, wind, and biofuel raises a number of environmental issues, notably changes in land use and adverse effects on wildlife. Airports offer one of the few land uses where reductions in wildlife abundance and habitat quality are necessary and socially acceptable, due to risk of wildlife collisions with aircraft. There are several uncertainties and limitations to establishing alternative energy production at airports, such as ensuring these facilities do not create wildlife attractants or other hazards. However, with careful planning, locating alternative energy projects at airports could help mitigate many of the challenges currently facing policy makers, developers, and conservationists.

  3. Software-as-a-Service Offer Differentiation by Business Unit

    Directory of Open Access Journals (Sweden)

    Islam Balbaa

    2011-01-01

    Full Text Available This article summarizes the author's recent research into the fit between software-as-a-service (SaaS tools and the requirements of particular business units. First, an overview of SaaS is provided, including a summary of its benefits to users and software vendors. Next, the approach used to gather and analyze data about the SaaS solutions offered on the Force.com AppExchange is outlined. Finally, the article describes the managerial implications of this research.

  4. The offer to eligible clients and gas purchase

    International Nuclear Information System (INIS)

    Willson, G.; Brun, C.; Lautard, Ph.

    2003-01-01

    This article gathers 4 presentations given at the 2003 natural gas congress of Paris about the impacts of the deregulation of the natural gas market. The first presentation presents the impact of the UK gas market deregulation on the energy expenses of the French tire manufacturer Michelin. The second presentation treats of Gaz de France offer to eligible clients. The third presentation presents the operation of the gas hub of Zeebrugge and the arbitration of prices, and the last presentation deals with the gas trading activity of Total company. (J.S.)

  5. Technical Training: WBTechT offers online training

    CERN Multimedia

    Monique Duval

    2005-01-01

    CERN Technical Training 2005 The 2005 CERN Web-Based Technical Training portal is a computer-skills site offering multimedia learning. Visit http://www.course-source.net/sites/cern/ to self-register, consult the available programmes or request a course via EDH. A self-directed online course costs 50.- CHF for desktop applications and 90.- CHF for technical applications for three months' unlimited access. Visit the WBTechT portal or http://www.cern.ch/TechnicalTraining, and contact Technical.Training@cern.ch or your DTOs to find out more information. ENSEIGNEMENT TECHNIQUE TECHNICAL TRAINING Monique Duval 74924 technical.training@cern.ch

  6. Technical Training: WBTechT offers online training

    CERN Multimedia

    Monique Duval

    2005-01-01

    CERN Technical Training 2005 The 2005 CERN Web-Based Technical Training (WBTechT) portal is a computer-skills site offering multimedia learning. Visit http://www.course-source.net/sites/cern/ to self-register, consult the available programmes or request a course via EDH. A self-directed online course costs 50.- CHF for desktop applications and 90.- CHF for technical applications for three months' unlimited access. Visit the WBTechT portal or http://www.cern.ch/TechnicalTraining, and contact Technical.Training@cern.ch or your DTO to find out more information. ENSEIGNEMENT TECHNIQUE TECHNICAL TRAINING Monique Duval 74924 technical.training@cern.ch

  7. Public offering system of research and development ideas in JAPC

    International Nuclear Information System (INIS)

    Yamamoto, Kazuhiko; Enami, Hisashi; Sakaiwaki, Yuuji; Nakayama, Yoshiyuki

    2011-01-01

    Public offering system of research and development ideas in The Japan Atomic Power Company (JAPC) is introduced. This system is established in 1999 to solve various subjects existing in JAPC's nuclear power stations by using highly advanced technique possessed by the enterprises or the organizations limited in Fukui Prefecture, and also to contribute them to become more advanced in their skill of technology. We have improved this system to make the results more applicable. We think it is important to coexist with the local community for the company engaged in nuclear energy as to cooperate together for the improvement of the local society. (author)

  8. Lafora disease offers a unique window into neuronal glycogen metabolism.

    Science.gov (United States)

    Gentry, Matthew S; Guinovart, Joan J; Minassian, Berge A; Roach, Peter J; Serratosa, Jose M

    2018-05-11

    Lafora disease (LD) is a fatal, autosomal recessive, glycogen-storage disorder that manifests as severe epilepsy. LD results from mutations in the gene encoding either the glycogen phosphatase laforin or the E3 ubiquitin ligase malin. Individuals with LD develop cytoplasmic, aberrant glycogen inclusions in nearly all tissues that more closely resemble plant starch than human glycogen. This Minireview discusses the unique window into glycogen metabolism that LD research offers. It also highlights recent discoveries, including that glycogen contains covalently bound phosphate and that neurons synthesize glycogen and express both glycogen synthase and glycogen phosphorylase. © 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

  9. Optimization method development of the core characteristics of a fast reactor in order to explore possible high performance solutions (a solution being a consistent set of fuel, core, system and safety)

    International Nuclear Information System (INIS)

    Ingremeau, J.-J.X.

    2011-01-01

    In the study of any new nuclear reactor, the design of the core is an important step. However designing and optimising a reactor core is quite complex as it involves neutronics, thermal-hydraulics and fuel thermomechanics and usually design of such a system is achieved through an iterative process, involving several different disciplines. In order to solve quickly such a multi-disciplinary system, while observing the appropriate constraints, a new approach has been developed to optimise both the core performance (in-cycle Pu inventory, fuel burn-up, etc...) and the core safety characteristics (safety estimators) of a Fast Neutron Reactor. This new approach, called FARM (Fast Reactor Methodology) uses analytical models and interpolations (Meta-models) from CEA reference codes for neutronics, thermal-hydraulics and fuel behaviour, which are coupled to automatically design a core based on several optimization variables. This global core model is then linked to a genetic algorithm and used to explore and optimise new core designs with improved performance. Consideration has also been given to which parameters can be best used to define the core performance and how safety can be taken into account.This new approach has been used to optimize the design of three concepts of Gas cooled Fast Reactor (GFR). For the first one, using a SiC/SiCf-cladded carbide-fuelled helium-bonded pin, the results demonstrate that the CEA reference core obtained with the traditional iterative method was an optimal core, but among many other possibilities (that is to say on the Pareto front). The optimization also found several other cores which exhibit some improved features at the expense of other safety or performance estimators. An evolution of this concept using a 'buffer', a new technology being developed at CEA, has hence been introduced in FARM. The FARM optimisation produced several core designs using this technology, and estimated their performance. The results obtained show that

  10. Possibilities for using a temperature-controlled pyrolysis method in order to determine the bonding form of mecury in soils and sediments; Moeglichkeiten der Anwendung eines temperaturgesteuerten Pyrolyseverfahrens zur Bestimmung der Bindungsform des Quecksilbers in Boeden und Sedimenten

    Energy Technology Data Exchange (ETDEWEB)

    Biester, H.

    1994-12-31

    The bonding behaviour of mercury in solids was investigated by means of a temperature-controlled pyrolysis method. Starting from the special property of elemental mercury to evaporate already at room temperature, a method was developed which permits to characterize different mercury bonding forms on the basis of Hg evaporation behaviour from solids at continuously increased temperature. The method starts from the assumption that it is possible to thermally reduce compounded mercury and release it in elemental form. The focus of the work was on the study of Hg bonding behaviour in soils and sediments. The soil samples used were from the areas of two mercury deposits, different kyanizing sites, some former mirror factories, and a chlor-alkali electrolysis workshop. The investigated sediments are a collection of mercury-polluted samples from the rivers Elbe, Rhine, Murg, the Rio Sao Joao de Meriti (Brazil) and some brooks and rivers of the Saar-Nahe depression. (orig./EF) [Deutsch] In der vorliegenden Arbeit wurde das Bindungsverhalten von Quecksilber in Feststoffen mittels eines temperaturgesteuerten Pyrolyseverfahrens untersucht. Ausgehend von der besonderen Eigenschaften des elementaren Quecksilbers, bereits bei Zimmertemperatur zu verdampfen, wurde ein Verfahren entwickelt, das eine Charakterisierung verschiedener Quecksilberbindungsformen aufgrund des Abdampfverhaltens des Hg aus dem Feststoff unter kontinuierlicher Temperaturerhoehung zulaesst. Dem Verfahren liegt dabei die Annahme zugrunde, dass sich das Quecksilber in seinen Verbindungen thermisch reduzieren und in elementarer Form freisetzen laesst. Durch den kontinuierlichen Aufheizprozess erfolgt die Freisetzung des Quecksilbers in Abhaengigkeit von der Bindungsstaerke in unterschiedlichen Temperaturbereichen. Die Darstellung der Ergebnisse erfolgte in Form von Abdampfkurven, die die Extinktion in Abhaengigkeit von der Temperatur darstellen. Der Schwerpunkt dieser Arbeit lag auf der Untersuchung des

  11. Possible future HERA analyses

    International Nuclear Information System (INIS)

    Geiser, Achim

    2015-12-01

    A variety of possible future analyses of HERA data in the context of the HERA data preservation programme is collected, motivated, and commented. The focus is placed on possible future analyses of the existing ep collider data and their physics scope. Comparisons to the original scope of the HERA pro- gramme are made, and cross references to topics also covered by other participants of the workshop are given. This includes topics on QCD, proton structure, diffraction, jets, hadronic final states, heavy flavours, electroweak physics, and the application of related theory and phenomenology topics like NNLO QCD calculations, low-x related models, nonperturbative QCD aspects, and electroweak radiative corrections. Synergies with other collider programmes are also addressed. In summary, the range of physics topics which can still be uniquely covered using the existing data is very broad and of considerable physics interest, often matching the interest of results from colliders currently in operation. Due to well-established data and MC sets, calibrations, and analysis procedures the manpower and expertise needed for a particular analysis is often very much smaller than that needed for an ongoing experiment. Since centrally funded manpower to carry out such analyses is not available any longer, this contribution not only targets experienced self-funded experimentalists, but also theorists and master-level students who might wish to carry out such an analysis.

  12. A Garden of Possibilities

    CERN Document Server

    Carolyn Lee

    2010-01-01

    Renowned landscape architect and designer Charles Jencks recently visited CERN along with the architect of the Globe, Hervé Dessimoz, to investigate the possibility of creating a cosmic-inspired garden at the entrance to the Laboratory.   Left to right: Charles Jencks, Peter Higgs, Rolf Heuer in the garden of cosmic speculation. Photo credit: University of Edinburgh/Maverick photo agency Charles Jencks is a master at designing whimsical, intriguing outdoor spaces that hold a much deeper meaning than just an interesting view. His Garden of Cosmic Speculation at his home in Scotland uses designs recalling cosmic forces, DNA, organic cells, spirals of time, black holes and the Universe, made with landform, plants, sculpture and water to re-shape the natural landscape. One of the possible symbols for CERN that came to his mind was the cosmic uroborus, an ancient Egyptian symbol of a snake eating its own tail dating back to 1600 BC. “Many scientists have discussed this as a poss...

  13. Will the next generation of basal insulins offer clinical advantages?

    Science.gov (United States)

    Garber, A J

    2014-06-01

    The 21st century has seen the arrival of several insulin analogue products and the refinement of insulin regimens, with widespread advocacy of continuous titration algorithms and earlier initiation of supplementary insulin therapy (predominantly using basal insulins) in type 2 diabetes. Nevertheless, many insulin-treated diabetes patients remain in poor glycaemic control. This might reflect insufficient titration effort or lax adherence, but these issues could in some cases result from concerns about hypoglycaemia. Certainly there is scope for improving the pharmacokinetic/pharmacodynamic (PK/PD) profile of basal insulin, and three new products offer this prospect. Insulin degludec, now in clinical use, and PEGylated insulin lispro, in development, have greatly extended action profiles that result from two very different, but unique, mechanisms. With once-daily dosing, these insulins produce stable PK/PD profiles at steady state, associated with a low incidence of hypoglycaemia. The feasibility of varied daily dose timing has also been confirmed with insulin degludec. High strength formulations of insulin glargine and insulin degludec offer the prospect of a reduced injection number/volume in high dose users, and in the case of glargine, the PK/PD profile might also be favourably modified. This review considers critically the clinical evidence and expectations we should have for these new basal insulins. © 2013 John Wiley & Sons Ltd.

  14. Market Timing, lifecycle stage and Seasoned Equity offerings

    Directory of Open Access Journals (Sweden)

    Vilma Sousa Ismael da Costa

    2014-08-01

    Full Text Available The tradeoff theory suggests that companies must issue shares to investments, when its leverage index is greater than your target rate, while the pecking order theory predicts that when capital offerings occur, the capital will be used to finance investments as the last source of funding, after their debt capacity have been exhausted. In contrast, the market timing theory predicts arguments that companies will adopt opportunistic behavior by issuing shares to take advantage of the high prices of the shares. Although the market timing theory has a significant influence on the decision to make a SEO, Brazilian literature contains little evidence about their economic importance and their effects. Thus, the present research aims to fill this gap in the Brazilian scenario. Specifically, we sought to assess the explanatory power of the relationship of market timing and the lifecycle theory in the issuance of SEO, which predicts that young companies with high market-to-book (MB and low operating cash flow sell shares to finance the investment, while mature companies, with low MB, pay dividends and fund investment internally. The sample was composed by non-financial companies with shares traded on BM&FBovespa. As main results, we can conclude that there is relationship between SEO and MB and size. On the other hand, were not observed evidence confirming the relationship between lifecycle stage and stock return, both in the previous year, and the year following the completion of the offer.

  15. Offering memorable patient experience through creative, dynamic marketing strategy

    Science.gov (United States)

    Raţiu, M; Purcărea, T

    2008-01-01

    Creative, dynamic strategies are the ones that identify new and better ways of uniquely offering the target customers what they want or need. A business can achieve competitive advantage if it chooses a marketing strategy that sets the business apart from anyone else. Healthcare services companies have to understand that the customer should be placed in the centre of all specific marketing operations. The brand message should reflect the focus on the patient. Healthcare products and services offered must represent exactly the solutions that customers expect. The touchpoints with the patients must be well mastered in order to convince them to accept the proposed solutions. Healthcare service providers must be capable to look beyond customer's behaviour or product and healthcare service aquisition. This will demand proactive and far–reaching changes, including focusing specifically on customer preference, quality, and technological interfaces; rewiring strategy to find new value from existing and unfamiliar sources; disintegrating and radically reassembling operational processes; and restructuring the organization to accommodate new typess of work and skill. PMID:20108466

  16. Optimal offering strategy for a concentrating solar power plant

    International Nuclear Information System (INIS)

    Dominguez, R.; Baringo, L.; Conejo, A.J.

    2012-01-01

    Highlights: ► Concentrating solar power (CSP) plants are becoming economically viable. ► CSP production is positively correlated with the demand. ► CSP plants can be made dispatchable by using molten salt storage facilities. ► Integrating CSP plants in a market constitutes a relevant challenge. -- Abstract: This paper provides a methodology to build offering curves for a concentrating solar power plant. This methodology takes into account the uncertainty in the thermal production from the solar field and the volatility of market prices. The solar plant owner is a price-taker producer that participates in a pool-based electricity market with the aim of maximizing its expected profit. To enhance the value of the concentrating solar power plant, a molten salt heat storage is considered, which allows producing electricity during periods without availability of the solar resource. To derive offering curves, a mixed-integer linear programming model is proposed, which is robust from the point of view of the uncertainty associated with the thermal production of the solar field and stochastic from the point of view of the uncertain market prices.

  17. Offering memorable patient experience through creative, dynamic marketing strategy.

    Science.gov (United States)

    Purcărea, Victor Lorín; Raţíu, Monica; Purcărea, Theodor; Davila, Carol

    2008-01-01

    Creative, dynamic strategies are the ones that identify new and better ways of uniquely offering the target customers what they want or need. A business can achieve competitive advantage if it chooses a marketing strategy that sets the business apart from anyone else. Healthcare services companies have to understand that the customer should be placed in the centre of all specific marketing operations. The brand message should reflect the focus on the patient. Healthcare products and services offered must represent exactly the solutions that customers expect. The touchpoints with the patients must be well mastered in order to convince them to accept the proposed solutions. Healthcare service providers must be capable to look beyond customer's behaviour or product and healthcare service aquisition. This will demand proactive and far-reaching changes, including focusing specifically on customer preference, quality, and technological interfaces; rewiring strategy to find new value from existing and unfamiliar sources: disintegrating and radically reassembling operational processes: and restructuring the organization to accommodate new types of work and skill.

  18. Brand positioning through banking services' offer: Serbian perspective

    Directory of Open Access Journals (Sweden)

    Novčić Branka

    2012-01-01

    Full Text Available The subject of this paper relates to the determination of interdependent relationship of the key elements necessary for the positioning of brands in the banking market in Serbia. The main goal of this paper is to analyze the way in which managers of banks in Serbia perceived brand positioning of banks in which they work, and the value of the customer service offer - corporate clients. Research focuses on identifying and comparing the dependent relationships between the key elements of offers' brand positioning: brand awareness, brand associations, perceived quality and brand loyalty. For the purpose of the research presented in this paper on-line surveying techniques was applied. 49 responses were collected form banking managers responsible for corporate clients. Results were analyzed using one-way analysis of variance (ANOVA.Acquired results indicate that there is a strong correlation between the observed elements: awareness of the brand-brand associations, brand association-perceived quality and perceived quality of brand-loyalty. Also, this paper provides an overview of the current position of the banking brands, as well as guidelines for improving the position of banking brands on the Serbian market.

  19. Possibilities of hydrogen removal

    International Nuclear Information System (INIS)

    Langer, G.; Koehling, A.; Nikodem, H.

    1982-12-01

    In the event of hypothetical severe accidents in light-water reactors, considerable amounts of hydrogen may be produced and released into the containment. Combustion of the hydrogen may jeopardize the integrity of the containment. The study reported here aimed to identify methods to mitigate the hydrogen problem. These methods should either prevent hydrogen combustion, or limit its effects. The following methods have been investigated: pre-inerting; chemical oxygen absorption; removal of oxygen by combustion; post-inerting with N 2 , CO 2 , or halon; aqueous foam; water fog; deliberate ignition; containment purging; and containment venting. The present state of the art in both nuclear and non-nuclear facilities, has been identified. The assessment of the methods was based on accident scenarios assuming significant release of hydrogen and the spectrum of requirements derived from these scenarios was used to determine the advantages and drawbacks of the various methods, assuming their application in a pressurized-water reactor of German design. (orig.) [de

  20. Pediatric oncologist willingness to offer germline TP53 testing in osteosarcoma.

    Science.gov (United States)

    Shaul, Eliana; Roth, Michael; Lo, Yungtai; Geller, David S; Hoang, Bang; Yang, Rui; Malkin, David; Gorlick, Richard; Gill, Jonathan

    2018-03-15

    Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome caused by mutations in the tumor-suppressor gene TP53. Osteosarcoma is a sentinel cancer in LFS. Prior studies using Sanger sequencing platforms have demonstrated that 3% of individuals with osteosarcoma harbor a mutation in TP53. New data from next-generation sequencing have demonstrated that 3.8% of patients with osteosarcoma have a known pathogenic variant, and an additional 5.7% carry exonic variants of unknown significance in TP53. Pediatric oncologists were e-mailed an anonymous 18-question survey assessing their willingness to offer TP53 germline testing to a child with osteosarcoma with or without a family history, and they were evaluated for changes in their choices with the prior data and the new data. One hundred seventy-seven pediatric oncologists (22%) responded to the survey. Respondents were more likely to offer TP53 testing to a patient with a positive family history (77.4% vs 12.4%; P offer TP53 testing once they were provided with the new data (25.4% vs 12.4%; P = .0038). The proportion of providers who responded that they were unsure increased significantly when they were presented with the new data (25.4% vs 10.2%; P = .0002). Potential implications for other family members and the possibility that surveillance imaging would detect new malignancies at an earlier stage were important factors influencing a provider's decision to offer TP53 testing. Recent data increase the proportion of providers willing to offer testing, and this suggests concern on the part of pediatric oncologists that variants of unknown significance may be disease-defining in rare cancers. Cancer 2018;124:1242-50. © 2018 American Cancer Society. © 2018 American Cancer Society.