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Sample records for metabolic research unit

  1. A human dietary arachidonic acid supplementation study conducted in a metabolic research unit: rationale and design.

    Nelson, G J; Kelley, D S; Emken, E A; Phinney, S D; Kyle, D; Ferretti, A

    1997-04-01

    While there are many reports of studies that fed arachidonic acid (AA) to animals, there are very few reports of AA feeding to humans under controlled conditions. This 130-d study was conceived as a controlled, symmetrical crossover design with healthy, adult male volunteers. They lived in the metabolic research unit (MRU) of the Western Human Nutrition Research (WHNRC) for the entire study. All food was prepared by the WHNRC kitchen. The basal (low-AA) diet consisted of natural foods (30 en% fat, 15 en% protein, and 55 en% carbohydrate), containing 210 mg/d of AA, and met the recommended daily allowance for all nutrients. The high-AA (intervention) diet was similar except that 1.5 g/d of AA in the form of a triglyceride containing 50% AA replaced an equal amount of high-oleic safflower oil in the basal diet. The subjects (ages 20 to 39) were within -10 to +20% of ideal body weight, nonsmoking, and not allowed alcohol in the MRU. Their exercise level was constant, and their body weights were maintained within 2% of entry level. Subjects were initially fed the low-AA diet for 15 d. On day 16, half of the subjects (group A) wee placed on the high-AA diet, and the other group (B) remained on the low-AA diets. On day 65, the two groups switched diets. On day 115, group B returned to the low-AA diet. This design, assuming no carryover effect, allowed us to merge the data from the two groups, with the data comparison days being 65 (low-AA) and 115 (high-AA) for group B and 130 (low-AA) and 65 (high-AA) for group A. The main indices studied were the fatty acid composition of the plasma, red blood cells, platelets, and adipose tissue; in vitro platelet aggregation, bleeding times, clotting factors; immune response as measured by delayed hypersensitivity skin tests, cellular proliferation of peripheral blood mononuclear cells in response to various mitogens and antigens, natural killer cell activity, and response to measles/mumps/rubella and influenza vaccines; the

  2. Uranium chemistry research unit

    Anon.

    1978-01-01

    The initial field of research of this Unit, established in 1973, was the basic co-ordination chemistry of uranium, thorium, copper, cobalt and nickel. Subsequently the interest of the Unit extended to extractive metallurgy relating to these metals. Under the term 'co-ordination chemistry' is understood the interaction of the central transition metal ion with surrounding atoms in its immediate vicinity (within bonding distance) and the influence they have on each other - for example, structural studies for determining the number and arrangement of co-ordinated atoms and spectrophotometric studies to establish how the f electron energy levels of uranium are influenced by the environment. New types of uranium compounds have been synthesized and studied, and the behaviour of uranium ions in non-aqueous systems has also received attention. This work can be applied to the development and study of extractants and new extractive processes for uranium

  3. Urban metabolism: A review of research methodologies

    Zhang, Yan

    2013-01-01

    Urban metabolism analysis has become an important tool for the study of urban ecosystems. The problems of large metabolic throughput, low metabolic efficiency, and disordered metabolic processes are a major cause of unhealthy urban systems. In this paper, I summarize the international research on urban metabolism, and describe the progress that has been made in terms of research methodologies. I also review the methods used in accounting for and evaluating material and energy flows in urban metabolic processes, simulation of these flows using a network model, and practical applications of these methods. Based on this review of the literature, I propose directions for future research, and particularly the need to study the urban carbon metabolism because of the modern context of global climate change. Moreover, I recommend more research on the optimal regulation of urban metabolic systems. Highlights: •Urban metabolic processes can be analyzed by regarding cities as superorganisms. •Urban metabolism methods include accounting, assessment, modeling, and regulation. •Research methodologies have improved greatly since this field began in 1965. •Future research should focus on carbon metabolism and optimal regulation. -- The author reviews research progress in the field of urban metabolism, and based on her literature review, proposes directions for future research

  4. Application Technology Research Unit

    Federal Laboratory Consortium — To conduct fundamental and developmental research on new and improved application technologies to protect floricultural, nursery, landscape, turf, horticultural, and...

  5. The Uranium Chemistry Research Unit

    Anon.

    1983-01-01

    The article discusses the research work done at the Uranium Chemistry Research Unit of the University of Port Elizabeth. The initial research programme dealt with fundamental aspects of uranium chemistry. New uranium compounds were synthesized and their chemical properties were studied. Research was also done to assist the mining industry, as well as on nuclear medicine. Special mentioning is made of the use of technetium for medical diagnosis and therapy

  6. Applications of NMR in biological metabolic research

    Nie Jiarui; Li Xiuqin; He Chunjian

    1989-01-01

    The nuclear magnetic resonance has become a powerful means of studying biological metabolism in non-invasive and non-destructive way. Being used to study the metabolic processes of living system in normal physiological conditions as well as in molecular level, the method is better than other conventional approaches. Using important parameters such as NMR-chemical shifts, longitudinal relaxation time and transverse relaxation time, it is possible to probe the metabolic processes as well as conformation, concentration, transportation and distribution of reacting and resulting substances. The NMR spectroscopy of 1 H, 31 P and 13 C nuclei has already been widely used in metabolic researches

  7. Interdisciplinary Pathways for Urban Metabolism Research

    Newell, J. P.

    2011-12-01

    With its rapid rise as a metaphor to express coupled natural-human systems in cities, the concept of urban metabolism is evolving into a series of relatively distinct research frameworks amongst various disciplines, with varying definitions, theories, models, and emphases. In industrial ecology, housed primarily within the disciplinary domain of engineering, urban metabolism research has focused on quantifying material and energy flows into, within, and out of cities, using methodologies such as material flow analysis and life cycle assessment. In the field of urban ecology, which is strongly influenced by ecology and urban planning, research focus has been placed on understanding and modeling the complex patterns and processes of human-ecological systems within urban areas. Finally, in political ecology, closely aligned with human geography and anthropology, scholars theorize about the interwoven knots of social and natural processes, material flows, and spatial structures that form the urban metabolism. This paper offers three potential interdisciplinary urban metabolism research tracks that might integrate elements of these three "ecologies," thereby bridging engineering and the social and physical sciences. First, it presents the idea of infrastructure ecology, which explores the complex, emergent interdependencies between gray (water and wastewater, transportation, etc) and green (e.g. parks, greenways) infrastructure systems, as nested within a broader socio-economic context. For cities to be sustainable and resilient over time-space, the theory follows, these is a need to understand and redesign these infrastructure linkages. Second, there is the concept of an urban-scale carbon metabolism model which integrates consumption-based material flow analysis (including goods, water, and materials), with the carbon sink and source dynamics of the built environment (e.g. buildings, etc) and urban ecosystems. Finally, there is the political ecology of the material

  8. Rodent Models for Metabolic Syndrome Research

    Sunil K. Panchal

    2011-01-01

    Full Text Available Rodents are widely used to mimic human diseases to improve understanding of the causes and progression of disease symptoms and to test potential therapeutic interventions. Chronic diseases such as obesity, diabetes and hypertension, together known as the metabolic syndrome, are causing increasing morbidity and mortality. To control these diseases, research in rodent models that closely mimic the changes in humans is essential. This review will examine the adequacy of the many rodent models of metabolic syndrome to mimic the causes and progression of the disease in humans. The primary criterion will be whether a rodent model initiates all of the signs, especially obesity, diabetes, hypertension and dysfunction of the heart, blood vessels, liver and kidney, primarily by diet since these are the diet-induced signs in humans with metabolic syndrome. We conclude that the model that comes closest to fulfilling this criterion is the high carbohydrate, high fat-fed male rodent.

  9. Clinical Research Strategies for Fructose Metabolism12

    Laughlin, Maren R.; Bantle, John P.; Havel, Peter J.; Parks, Elizabeth; Klurfeld, David M.; Teff, Karen; Maruvada, Padma

    2014-01-01

    Fructose and simple sugars are a substantial part of the western diet, and their influence on human health remains controversial. Clinical studies in fructose nutrition have proven very difficult to conduct and interpret. NIH and USDA sponsored a workshop on 13–14 November 2012, “Research Strategies for Fructose Metabolism,” to identify important scientific questions and parameters to be considered while designing clinical studies. Research is needed to ascertain whether there is an obesogenic role for fructose-containing sugars via effects on eating behavior and energy balance and whether there is a dose threshold beyond which these sugars promote progression toward diabetes and liver and cardiovascular disease, especially in susceptible populations. Studies tend to fall into 2 categories, and design criteria for each are described. Mechanistic studies are meant to validate observations made in animals or to elucidate the pathways of fructose metabolism in humans. These highly controlled studies often compare the pure monosaccharides glucose and fructose. Other studies are focused on clinically significant disease outcomes or health behaviors attributable to amounts of fructose-containing sugars typically found in the American diet. These are designed to test hypotheses generated from short-term mechanistic or epidemiologic studies and provide data for health policy. Discussion brought out the opinion that, although many mechanistic questions concerning the metabolism of monosaccharide sugars in humans remain to be addressed experimentally in small highly controlled studies, health outcomes research meant to inform health policy should use large, long-term studies using combinations of sugars found in the typical American diet rather than pure fructose or glucose. PMID:24829471

  10. Clinical Epidemiology Unit - overview of research areas

    Clinical Epidemiology Unit (CEU) conducts etiologic research with potential clinical and public health applications, and leads studies evaluating population-based early detection and cancer prevention strategies

  11. The United Nuclear Research Institute

    Kiss, D.

    1978-01-01

    The UNRI, the only common institute of the socialist countries was founded in 1956 in Dubna. The scientists of small countries have the opportunity to take part in fundamental research with very expensive devices which are usually not available for them. There are six research laboratories and one department in the UNRI namely: the theoretical physical laboratory; the laboratory of high energies - there is a synchrophasotron of 1a GeV there; the laboratory of nuclear problems - there is a synchrocyclotron of 680 MeV there; the laboratory of nuclear reactions with the cyclotron U-300 which can accelerate heavy ions; the neutronphysical laboratory with the impulse reactor IBM-30; the laboratory of computation and automatization with two big computers; the department of new acceleration methods. The main results obtained by Hungarian scientist in Dubna are described. (V.N.)

  12. [Genomic research of traditional Chinese medicines in vivo metabolism].

    Xiao, Shui-Ming; Bai, Rui; Zhang, Xiao-Yan

    2016-11-01

    Gene is the base of in vivo metabolism and effectiveness for traditional Chinese medicines (TCM), and the gene expression, regulation and modification are used as the research directions to perform the TCM multi-component, multi-link and multi-target in vivo metabolism studies, which will improve the research on TCM metabolic proecess, effect target and molecular mechanism. Humans are superorganisms with 1% genes inherited from parents and 99% genes from various parts of the human body, mainly coming from the microorganisms in intestinal flora. These indicate that genetically inherited human genome and "second genome" could affect the TCM in vivo metabolism from inheritance and "environmental" aspects respectively. In the present paper, typical case study was used to discuss related TCM in vivo metabolic genomics research, mainly including TCM genomics research and gut metagenomics research, as well as the personalized medicine evoked from the individual difference of above genomics (metagenomics). Copyright© by the Chinese Pharmaceutical Association.

  13. The progress on researching method and metabolism of positron radiopharmaceutical

    Gan Hongmei; Qiao Jinping; Kong Aiying; Zhu Lin

    2010-01-01

    Positron radiopharmaceuticals are mainly used for PET studies, which are used in the field of nuclear medicine as tracers in the diagnosis and treatment of many diseases. They have important position and function in the clinical diagnosis and treatment. Metabolism or biotransformation will happen when PET radio-pharmaceuticals enter into the body. Understanding the metabolic fate of radiopharmaceutical probes is essential for an accurate analysis and interpretation of positron emission tomography imaging. The recent research progress on PET radiopharmaceuticals metabolism was reviewed in this paper, including the metabolism characteristics, research methods, analytical techniques and so on. (authors)

  14. Research at the Dairy and Functional Foods Research Unit

    Dr. Peggy Tomasula is Research Leader of the Dairy and Functional Foods Research Unit (DFFRU), ARS, USDA, Wyndmoor, PA, a group that includes 11 Research Scientists, 4 of whom are Lead Scientists (LS), 13 support scientists, and 3 Retired Collaborators. The mission of the DFFRU is to solve critical ...

  15. 2011 Plant Lipids: Structure, Metabolism, & Function Gordon Research Conference

    Christopher Benning

    2011-02-04

    This is the second Gordon Research Conference on 'Plant Lipids: Structure, Metabolism & Function'. It covers current topics in lipid structure, metabolism and function in eukaryotic photosynthetic organisms including seed plants, algae, mosses and ferns. Work in photosynthetic bacteria is considered as well as it serves the understanding of specific aspects of lipid metabolism in plants. Breakthroughs are discussed in research on plant lipids as diverse as glycerolipids, sphingolipids, lipids of the cell surface, isoprenoids, fatty acids and their derivatives. The program covers nine concepts at the forefront of research under which afore mentioned plant lipid classes are discussed. The goal is to integrate areas such as lipid signaling, basic lipid metabolism, membrane function, lipid analysis, and lipid engineering to achieve a high level of stimulating interaction among diverse researchers with interests in plant lipids. One Emphasis is on the dynamics and regulation of lipid metabolism during plant cell development and in response to environmental factors.

  16. 2007 Plant Metabolic Engineering Gordon Conference and Graduate Research Seminar

    Erich Grotewold

    2008-09-15

    Plant Metabolic Engineering is an emerging field that integrates a diverse range of disciplines including plant genetics, genomics, biochemistry, chemistry and cell biology. The Gordon-Kenan Graduate Research Seminar (GRS) in Plant Metabolic Engineering was initiated to provide a unique opportunity for future researcher leaders to present their work in this field. It also creates an environment allowing for peer-review and critical assessment of work without the intimidation usually associated with the presence of senior investigators. The GRS immediately precedes the Plant Metabolic Engineering Gordon Research Conference and will be for and by graduate students and post-docs, with the assistance of the organizers listed.

  17. Biochemical research elucidating metabolic pathways in Pneumocystis*

    Kaneshiro E.S.

    2010-12-01

    Full Text Available Advances in sequencing the Pneumocystis carinii genome have helped identify potential metabolic pathways operative in the organism. Also, data from characterizing the biochemical and physiological nature of these organisms now allow elucidation of metabolic pathways as well as pose new challenges and questions that require additional experiments. These experiments are being performed despite the difficulty in doing experiments directly on this pathogen that has yet to be subcultured indefinitely and produce mass numbers of cells in vitro. This article reviews biochemical approaches that have provided insights into several Pneumocystis metabolic pathways. It focuses on 1 S-adenosyl-L-methionine (AdoMet; SAM, which is a ubiquitous participant in numerous cellular reactions; 2 sterols: focusing on oxidosqualene cyclase that forms lanosterol in P. carinii; SAM:sterol C-24 methyltransferase that adds methyl groups at the C-24 position of the sterol side chain; and sterol 14α-demethylase that removes a methyl group at the C-14 position of the sterol nucleus; and 3 synthesis of ubiquinone homologs, which play a pivotal role in mitochondrial inner membrane and other cellular membrane electron transport.

  18. Toxic Hazards Research Unit Annual Report: 1986

    1987-04-01

    mediated hemolysis by mercapto compounds. Journal of Applied Toxicology, Volume 6, Number 5, pages 336-370, 1986. Hydrophobic tributyltin ( TBT ...7 ~OF~ AAMRL-TR-87-020 NMRI-87-2 ’~LRES 4 Iq 1986 TOXIC HAZARDS RESEARCH UNIT ANNUAL REPORT WILLIAM E. HOUSTON, Ph.D. RAYMOND S. KUTZMAN, Ph.D...and is approved for publication. FOR THE COMMANDElRi BRUCE 0. STUART, Ph.D. Director, Toxic Hazards Division Harry G. Armstrong Aerospace Medical

  19. Advances in drug metabolism and pharmacogenetics research in Australia.

    Mackenzie, Peter I; Somogyi, Andrew A; Miners, John O

    2017-02-01

    Metabolism facilitates the elimination, detoxification and excretion in urine or bile (as biotransformation products) of a myriad of structurally diverse drugs and other chemicals. The metabolism of drugs, non-drug xenobiotics and many endogenous compounds is catalyzed by families of drug metabolizing enzymes (DMEs). These include the hemoprotein-containing cytochromes P450, which function predominantly as monooxygenases, and conjugation enzymes that transfer a sugar, sulfate, acetate or glutathione moiety to substrates containing a suitable acceptor functional group. Drug and chemical metabolism, especially the enzymes that catalyse these reactions, has been the research focus of several groups in Australia for over four decades. In this review, we highlight the role of recent and current drug metabolism research in Australia, including elucidation of the structure and function of enzymes from the various DME families, factors that modulate enzyme activity in humans (e.g. drug-drug interactions, gene expression and genetic polymorphism) and the application of in vitro approaches for the prediction of drug metabolism parameters in humans, along with the broader pharmacological/clinical pharmacological and toxicological significance of drug metabolism and DMEs and their relevance to drug discovery and development, and to clinical practice. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Research of Houjiayao Unit in North China

    Ji, Y.

    2012-12-01

    "Houjiayao Group" is the standard stratigraphic unit of late Pleistocene in northern China, which was created by Jia Lanpo and Wei Qi during their research on Houjiayao site. Based on the mammal, ancient human fossils and Paleolithic features, "Houjiayao Group" was thought as late Pleistocene sediments. "Houjiayao Group" was defined as late Pleistocene stratigraphic units. However, the problems of the age of "Houjiayao Group", stratigraphic division and other issues, have not yet been well resolved. These issues include: the differences of age-dating results, the unclear comparison between stratigraphic units and regional contrast, the uncertain relationship between "Houjiayao Group" and "Nihewan Layer ", and so on. Houjiayao site which located in the southeast of Houjiayao village in Dongjingji town Yangyuan County, Hebei province of China, is a very important paleolithic site. But some researches show that Houjiayao site is located at the 3th terrace of Liyigou valley and there are many opinions about the age of Houjiayao site, which varies from 20-500 thousand years. Combined with former research results and many research methods, our study was mainly focused on the key problems existing in the study of "Houjiayao Group". Through the use of sequence stratigraphy, chronostratigraphy, biostratigraphy and other theoretical methods, stratigraphic section was studied in the late Pleistocene stratigraphy and sedimentary environment. Through environmental indicators and the age-dating tests, the evolution of ancient geography and environment were identified elementarily. After analyzing informations of this area, geomorphologic investigation and stratum comparation in and around Houjiayao site were done. Houjiayao site is located on the west bank of Liyigou river, which has a tributary named Black Stone River. Two or three layers of volcanic materials were found in this area, those sediments are from a buried paleovolcano in upstream of Black Stone River. The volcanic

  1. metabolicMine: an integrated genomics, genetics and proteomics data warehouse for common metabolic disease research.

    Lyne, Mike; Smith, Richard N; Lyne, Rachel; Aleksic, Jelena; Hu, Fengyuan; Kalderimis, Alex; Stepan, Radek; Micklem, Gos

    2013-01-01

    Common metabolic and endocrine diseases such as diabetes affect millions of people worldwide and have a major health impact, frequently leading to complications and mortality. In a search for better prevention and treatment, there is ongoing research into the underlying molecular and genetic bases of these complex human diseases, as well as into the links with risk factors such as obesity. Although an increasing number of relevant genomic and proteomic data sets have become available, the quantity and diversity of the data make their efficient exploitation challenging. Here, we present metabolicMine, a data warehouse with a specific focus on the genomics, genetics and proteomics of common metabolic diseases. Developed in collaboration with leading UK metabolic disease groups, metabolicMine integrates data sets from a range of experiments and model organisms alongside tools for exploring them. The current version brings together information covering genes, proteins, orthologues, interactions, gene expression, pathways, ontologies, diseases, genome-wide association studies and single nucleotide polymorphisms. Although the emphasis is on human data, key data sets from mouse and rat are included. These are complemented by interoperation with the RatMine rat genomics database, with a corresponding mouse version under development by the Mouse Genome Informatics (MGI) group. The web interface contains a number of features including keyword search, a library of Search Forms, the QueryBuilder and list analysis tools. This provides researchers with many different ways to analyse, view and flexibly export data. Programming interfaces and automatic code generation in several languages are supported, and many of the features of the web interface are available through web services. The combination of diverse data sets integrated with analysis tools and a powerful query system makes metabolicMine a valuable research resource. The web interface makes it accessible to first

  2. American Society for Metabolic and Bariatric Surgery estimation of metabolic and bariatric procedures performed in the United States in 2016.

    English, Wayne J; DeMaria, Eric J; Brethauer, Stacy A; Mattar, Samer G; Rosenthal, Raul J; Morton, John M

    2018-03-01

    Bariatric surgery, despite being the most successful long-lasting treatment for morbid obesity, remains underused as only approximately 1% of all patients who qualify for surgery actually undergo surgery. To determine if patients in need are receiving appropriate therapy, the American Society for Metabolic and Bariatric Surgery created a Numbers Taskforce to specify annual rate of use for obesity treatment interventions. The objective of this study was to determine metabolic and bariatric procedure trends since 2011 and to provide the best estimate of the number of procedures performed in the United States in 2016. United States. We reviewed data from the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program, National Surgical Quality Improvement Program, Bariatric Outcomes Longitudinal Database, and Nationwide Inpatient Sample. In addition, data from industry and outpatient centers were used to estimate outpatient center activity. Data from 2016 were compared with the previous 5 years of data. Compared with 2015, the total number of metabolic and bariatric procedures performed in 2016 increased from approximately 196,000 to 216,000. The sleeve gastrectomy trend is increasing, and it continues to be the most common procedure. The gastric bypass and gastric band trends continued to decrease as seen in previous years. The percentage of revision procedures and biliopancreatic diversion with duodenal switch procedures increased slightly. Finally, intragastric balloons placement emerged as a significant contributor to the cumulative total number of procedures performed. There is increasing use of metabolic and bariatric procedures performed in the United States from 2011 to 2016, with a nearly 10% increase noted from 2015 to 2016. Copyright © 2018 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.

  3. Association between Lifestyle Factors and Metabolic Syndrome among African Americans in the United States

    Chintan J. Bhanushali

    2013-01-01

    Full Text Available Background. Although there is a reported association between lifestyle factors and metabolic syndrome, very few studies have used national level data restricted to the African Americans (AAs in the United States (US. Methods. A cross-sectional evaluation was conducted using the National Health and Nutrition Examination Survey from 1999 to 2006 including men and nonpregnant women of 20 years or older. Multiple logistic regression models were constructed to evaluate the association between lifestyle factors and metabolic syndrome. Results. AA women had a higher prevalence of metabolic syndrome (39.43% than AA men (26.77%. After adjusting for sociodemographic factors, no significant association was found between metabolic syndrome and lifestyle factors including alcohol drinking, cigarette smoking, and physical activity. Age and marital status were significant predictors for metabolic syndrome. With increase in age, both AA men and AA women were more likely to have metabolic syndrome (AA men: ORadj=1.05, 95% CI 1.04–1.06, AA women: ORadj=1.06, 95% CI 1.04–1.07. Single AA women were less likely to have metabolic syndrome than married women (ORadj=0.66, 95% CI 0.43–0.99. Conclusion. Lifestyle factors had no significant association with metabolic syndrome but age and marital status were strong predictors for metabolic syndrome in AAs in the US.

  4. 1995 Toxic Hazards Research Unit Annual Report.

    1996-07-01

    Fifth edition, pp 1640-1641. Cannon, W.C., E.F. Blanton, and K.E. McDonald . 1983. Am. Ind. Hyg. Assoc. 44(12):923933. Capen, C.C. 1995. In: "Casarett...recirculating gas uptake system with a volume of 8.0 L was used for the estimation of whole animal metabolic constants (Vmaxc, K,,,, and Kfc ) (Gargas...Cannon, W.C., E.F. Blanton, and K.E. McDonald . 1983. The flowpast chamber: an improved nose-only exposure system for rodents. Am. Ind. Hyg. Assoc. J. 44

  5. Basic Research in the United States.

    Handler, Philip

    1979-01-01

    Presents a discussion of the development of basic research in the U.S. since World War II. Topics include the creation of the federal agencies, physics and astronomy, chemistry, earth science, life science, the environment, and social science. (BB)

  6. Patterns of research utilization on patient care units

    Lander Janice

    2008-06-01

    Full Text Available Abstract Background Organizational context plays a central role in shaping the use of research by healthcare professionals. The largest group of professionals employed in healthcare organizations is nurses, putting them in a position to influence patient and system outcomes significantly. However, investigators have often limited their study on the determinants of research use to individual factors over organizational or contextual factors. Methods The purpose of this study was to examine the determinants of research use among nurses working in acute care hospitals, with an emphasis on identifying contextual determinants of research use. A comparative ethnographic case study design was used to examine seven patient care units (two adult and five pediatric units in four hospitals in two Canadian provinces (Ontario and Alberta. Data were collected over a six-month period by means of quantitative and qualitative approaches using an array of instruments and extensive fieldwork. The patient care unit was the unit of analysis. Drawing on the quantitative data and using correspondence analysis, relationships between various factors were mapped using the coefficient of variation. Results Units with the highest mean research utilization scores clustered together on factors such as nurse critical thinking dispositions, unit culture (as measured by work creativity, work efficiency, questioning behavior, co-worker support, and the importance nurses place on access to continuing education, environmental complexity (as measured by changing patient acuity and re-sequencing of work, and nurses' attitudes towards research. Units with moderate research utilization clustered on organizational support, belief suspension, and intent to use research. Higher nursing workloads and lack of people support clustered more closely to units with the lowest research utilization scores. Conclusion Modifiable characteristics of organizational context at the patient care unit

  7. Bubble Chamber Research Group Microcomputer Unit

    Bairstow, R.; Barlow, J.; Mace, P.R.; Seller, P.; Waters, M.; Watson, J.G.

    1982-05-01

    A distributed data acquisition system has been developed by the Bubble Chamber Research Group at the Rutherford Appleton laboratory for use with their film measuring machines. The system is based upon a set of microcomputers linked together with a VAX 11/780 computer, in a local area computer network. This network is of the star type and uses a packet switching technique. Each film measuring machine is equipped with a microcomputer which controls the function of the table, buffers data and enhances the interface between operators and machines. This paper provides a detailed description of each microcomputer and can be used as a reference manual for these computers. (author)

  8. RESEARCH OF THE METABOLIC AGE AND BODY MASS INDEX FOR FEMALE STUDENTS

    Galina Petrova Dyakova

    2011-09-01

    Full Text Available Metabolic age - this feature takes into account, the basic metabolism and all the basic physical parameters and the determining of age, which corresponds to this type of metabolism. The aim of the research is to establish a metabolic age and the index of the body mass (Body Mass Index for students. Anthropometric measurement was applied. The analyzer was used for the composition of body weight (body composition analyzer, BC-420MA “Tanita” for determining the metabolic age and body mass index. The conducted monitoring of the metabolic age reveals opportunities to improve students' motivation for healthy lifestyle.

  9. Archaeomagnetic research in the United States midcontinent

    Lengyel, Stacey Nicole

    This dissertation combines archaeomagnetic and independent chronometric data from 240 archaeological features to develop a regional secular variation curve for the U.S. midcontinent. These data were obtained from features located between 31.5--40.5° N latitude and 82.5--93.5° W longitude that have been dated to between 60 and 10,700 cal BP. The archaeomagnetic samples were collected from 41 sites within this region over the past 35 years under the direction of four different researchers: Robert DuBois (University of Oklahoma), Daniel Wolfman (University of Arkansas and New Mexico State Museum), Wulf Gose (University of Texas at Austin), and myself. In this project, the data are initially smoothed through the moving windows method to form the first approximation of the curve. Outlier analyses and pairwise statistical comparisons are utilized to refine the smoothed curve, and the results are compared to other Holocene-aged secular variation records from North America. These analyses indicate that the final curve should be treated as three distinct segments with different precision and use recommendations. First, the 850--75 cal BP segment can be used to date archaeomagnetic sample from the project area with expected temporal precision of 100--200 years. Second, the 2528--850 cal BP segment can be used cautiously to date archaeomagnetic samples with an expected temporal precision of 200--300 years. Third, the 9755--4650 cal BP segment should be used for contextual dating purposes only, in that an undated sample can be put into a regional context through comparison with the segment's constituent samples. Finally, three archaeological problems are addressed through the archaeomagnetic data. First, archaeomagnetic data are used to resolve the temporal conflict between an eastern Tennessee structure's morphology and a much earlier radiocarbon date obtained for the structure. Then, archaeomagnetic data are used to address a number of internal chronology questions

  10. Research needs in metabolism and dosimetry of the actinides

    Richmond, C.R.

    1978-01-01

    The following topics are discussed: uranium mine and mill tailings; environmental standards; recommendations of NCRP and ICRP; metabolic models and health effects; life-time exposures to actinides and other alpha emitters; high-specific-activity actinide isotopes versus naturally occurring isotopic mixtures of uranium isotopes; adequacy of the n factor; and metabolism and dosimetry;

  11. Highlight: Research Chair unites four West African universities in ...

    2016-04-14

    Apr 14, 2016 ... Local and regional experts including researchers, consultants, and academics convened in Cotonou, Benin, on February 26, 2015 to launch a Research Chair on EcoHealth. The Chair unites four West African universities that have pledged to reduce air pollution and non-communicable respiratory ...

  12. Future Directions for Urban Forestry Research in the United States

    John F. Dwyer; David J. Nowak; Gary W. Watson

    2002-01-01

    Urban forestry research promises to continue to be an integral part of the growth and development of forestry in urban and urbanizing areas of the United States. The future is expected to bring increased emphasis on research in support of the care of trees and other plants, ecological restoration, and comprehensive and adaptive management across the landscape....

  13. Infusing Active Learning into the Research Methods Unit

    Bluestone, Cheryl

    2007-01-01

    The research methods unit of survey psychology classes introduces important concepts of scientific reasoning and fluency, making it an ideal course in which to deliver enhanced curricula. To increase interest and engagement, the author developed an expanded research methods and statistics module to give students the opportunity to explore…

  14. Identification of Mutations Underlying 20 Inborn Errors of Metabolism in the United Arab Emirates Population

    Ben-Rebeh, Imen; Hertecant, Jozef L.; Al-Jasmi, Fatma A.; Aburawi, Hanan E.; Al-Yahyaee, Said A.; Al-Gazali, Lihadh

    2012-01-01

    Inborn errors of metabolism (IEM) are frequently encountered by physicians in the United Arab Emirates (UAE). However, the mutations underlying a large number of these disorders have not yet been determined. Therefore, the objective of this study was to identify the mutations underlying a number of IEM disorders among UAE residents from both national and expatriate families. A case series of patients from 34 families attending the metabolic clinic at Tawam Hospital were clinically evaluated, and molecular testing was carried out to determine their causative mutations. The mutation analysis was carried out at molecular genetics diagnostic laboratories. Thirty-eight mutations have been identified as responsible for twenty IEM disorders, including in the metabolism of amino acids, lipids, steroids, metal transport and mitochondrial energy metabolism, and lysosomal storage disorders. Nine of the identified mutations are novel, including two missense mutations, three premature stop codons and four splice site mutations. Mutation analysis of IEM disorders in the UAE population has an important impact on molecular diagnosis and genetic counseling for families affected by these disorders. PMID:22106832

  15. Metabolism

    ... Are More Common in People With Type 1 Diabetes Metabolic Syndrome Your Child's Weight Healthy Eating Endocrine System Blood Test: Basic Metabolic Panel (BMP) Activity: Endocrine System Growth Disorders Diabetes Center Thyroid Disorders Your Endocrine System Movie: Endocrine ...

  16. The Microcomputer in the Clinical Nursing Research Unit

    Schwirian, Patricia M.; Byers, Sandra R.

    1982-01-01

    This paper discusses the microcomputer in clinical nursing research. There are six general areas in which computers have been useful to nurses: nursing notes and charting; patient care plans; automated monitoring of high-tech nursing units; HIS and MIS systems; personnel distribution systems; and education. Three alternative models for the conduct of clinical nursing research in a hospital are described. The first is a centralized model relying on the bureaucratic structure of the hospital. Second is a decentralized network of professional nurses and research support personnel woven together by a Clinical Nurse Researcher, and third is a dedicated clinical nursing research unit. Microcomputers have five characteristics which make them vital tools for nurse researchers: user-friendliness; environment friendliness; low cost; ease of interface with other information systems; and range and quality of software.

  17. Achievement report on research and development of medical and welfare equipment technology. Unit {sup 13}C-MRS for noninvasive measurement of brain metabolism; Iryo fukushi kiki gijutsu kenkyu kaihatsu seika hokokusho. Mushinshuteki no taisha keisokuyo {sup 1}3C-MRS sochi

    NONE

    1999-11-01

    The effort is to develop technologies of conducting highly sensitive, uninterrupted observation of metabolism in the brain by use of the {sup 13}C-MRS unit, for which some carbon chain compounds (glucose, amino acids, etc.), which assume an important part in metabolism, are labelled by a stable isotope {sup 13}C and then administered to living things. A multi-slice HSQC (heteronuclear single quantum coherence) method is developed for the achievement of sensitivity enhanced 16 folds, excellent compound isolating capability, and high localizing capability, and these contribute to the specification of an optimum pulse sequence. A double tuning coil is developed for transmission, and a 6-channel multi-surface coil for reception, these two providing a 3-fold increase in detection probe sensitivity. The nonlinear least-square method is applied for the processing of spectral data, which enables excellent isolation of compounds. It also enables the generation of an inclined magnetic field quick to rise and of a sequence high in amplitude/phase accuracy. New methods are developed for the synthesis of {sup 13}C-labelled glucose, dopa, glutamine, glutamic acid, and GABA (gamma-aminobutyric acid) which are expected to be useful in brain metabolism measurement, and the products are administered to animals for evaluation. (NEDO)

  18. Longitudinal Omics Modelling and Integration in Clinical Metabonomics Research: challenges in childhood metabolic health research

    Peter eSperisen

    2015-08-01

    Full Text Available Systems biology is an important approach for deciphering the complex processes in health maintenance and the etiology of metabolic diseases. Such integrative methodologies will help better understand the molecular mechanisms involved in growth and development throughout childhood, and consequently will result in new insights about metabolic and nutritional requirements of infants, children and adults. To achieve this, a better understanding of the physiological processes at anthropometric, cellular and molecular level for any given individual is needed. In this respect, novel omics technologies in combination with sophisticated data modelling techniques are key. Due to the highly complex network of influential factors determining individual trajectories, it becomes imperative to develop proper tools and solutions that will comprehensively model biological information related to growth and maturation of our body functions. The aim of this review and perspective is to evaluate, succinctly, promising data analysis approaches to enable data integration for clinical research, with an emphasis on the longitudinal component. Approaches based on empirical and mechanistic modelling of omics data are essential to leverage findings from high dimensional omics datasets and enable biological interpretation and clinical translation. On the one hand, empirical methods, which provide quantitative descriptions of patterns in the data, are mostly used for exploring and mining datasets. On the other hand, mechanistic models are based on an understanding of the behavior of a system’s components and condense information about the known functions, allowing robust and reliable analyses to be performed by bioinformatics pipelines and similar tools. Herein, we will illustrate current examples, challenges and perspectives in the applications of empirical and mechanistic modelling in the context of childhood metabolic health research.

  19. Niche differentiation in nitrogen metabolism among methanotrophs within an operational taxonomic unit.

    Hoefman, Sven; van der Ha, David; Boon, Nico; Vandamme, Peter; De Vos, Paul; Heylen, Kim

    2014-04-04

    The currently accepted thesis on nitrogenous fertilizer additions on methane oxidation activity assumes niche partitioning among methanotrophic species, with activity responses to changes in nitrogen content being dependent on the in situ methanotrophic community structure Unfortunately, widely applied tools for microbial community assessment only have a limited phylogenetic resolution mostly restricted to genus level diversity, and not to species level as often mistakenly assumed. As a consequence, intragenus or intraspecies metabolic versatility in nitrogen metabolism was never evaluated nor considered among methanotrophic bacteria as a source of differential responses of methane oxidation to nitrogen amendments. We demonstrated that fourteen genotypically different Methylomonas strains, thus distinct below the level at which most techniques assign operational taxonomic units (OTU), show a versatile physiology in their nitrogen metabolism. Differential responses, even among strains with identical 16S rRNA or pmoA gene sequences, were observed for production of nitrite and nitrous oxide from nitrate or ammonium, nitrogen fixation and tolerance to high levels of ammonium, nitrate, and hydroxylamine. Overall, reduction of nitrate to nitrite, nitrogen fixation, higher tolerance to ammonium than nitrate and tolerance and assimilation of nitrite were general features. Differential responses among closely related methanotrophic strains to overcome inhibition and toxicity from high nitrogen loads and assimilation of various nitrogen sources yield competitive fitness advantages to individual methane-oxidizing bacteria. Our observations proved that community structure at the deepest phylogenetic resolution potentially influences in situ functioning.

  20. Economics of conservation systems research in the Southeastern United States

    The use of conservation systems in crop production is not a new concept in the southeastern United States. In 1978, researchers from across the Southeast met in Griffin, Georgia for the first annual Southern Conservation Agricultural Systems Conference. Four of the ten presentations specifically men...

  1. Conducting qualitative research within Clinical Trials Units: avoiding potential pitfalls.

    Cooper, Cindy; O'Cathain, Alicia; Hind, Danny; Adamson, Joy; Lawton, Julia; Baird, Wendy

    2014-07-01

    The value of using qualitative research within or alongside randomised controlled trials (RCTs) is becoming more widely accepted. Qualitative research may be conducted concurrently with pilot or full RCTs to understand the feasibility and acceptability of the interventions being tested, or to improve trial conduct. Clinical Trials Units (CTUs) in the United Kingdom (UK) manage large numbers of RCTs and, increasingly, manage the qualitative research or collaborate with qualitative researchers external to the CTU. CTUs are beginning to explicitly manage the process, for example, through the use of standard operating procedures for designing and implementing qualitative research with trials. We reviewed the experiences of two UK Clinical Research Collaboration (UKCRC) registered CTUs of conducting qualitative research concurrently with RCTs. Drawing on experiences gained from 15 studies, we identify the potential for the qualitative research to undermine the successful completion or scientific integrity of RCTs. We show that potential problems can arise from feedback of interim or final qualitative findings to members of the trial team or beyond, in particular reporting qualitative findings whilst the trial is on-going. The problems include: We make recommendations for improving the management of qualitative research within CTUs. Copyright © 2014. Published by Elsevier Inc.

  2. The intensive care medicine research agenda in nutrition and metabolism

    Arabi, Yaseen M; Casaer, Michael P; Chapman, Marianne; Heyland, Daren K; Ichai, Carole; Marik, Paul E; Martindale, Robert G; McClave, Stephen A; Preiser, Jean-Charles; Reignier, Jean; Rice, Todd W; Van den Berghe, Greet; van Zanten, Arthur R H; Weijs, Peter J M

    PURPOSE: The objectives of this review are to summarize the current practices and major recent advances in critical care nutrition and metabolism, review common beliefs that have been contradicted by recent trials, highlight key remaining areas of uncertainty, and suggest recommendations for the top

  3. Metabolism

    ... lin), which signals cells to increase their anabolic activities. Metabolism is a complicated chemical process, so it's not ... how those enzymes or hormones work. When the metabolism of body chemicals is ... Hyperthyroidism (pronounced: hi-per-THIGH-roy-dih-zum). Hyperthyroidism ...

  4. United States Domestic Research Reactor Infrastructure TRIGA Reactor Fuel Support

    Morrell, Douglas

    2011-01-01

    The United State Domestic Research Reactor Infrastructure Program at the Idaho National Laboratory manages and provides project management, technical, quality engineering, quality inspection and nuclear material support for the United States Department of Energy sponsored University Reactor Fuels Program. This program provides fresh, unirradiated nuclear fuel to Domestic University Research Reactor Facilities and is responsible for the return of the DOE-owned, irradiated nuclear fuel over the life of the program. This presentation will introduce the program management team, the universities supported by the program, the status of the program and focus on the return process of irradiated nuclear fuel for long term storage at DOE managed receipt facilities. It will include lessons learned from research reactor facilities that have successfully shipped spent fuel elements to DOE receipt facilities.

  5. Research and photovoltaic industry at the United States

    Lerouge, Ch.; Herino, R.; Delville, R.; Allegre, R.

    2006-06-01

    For a big country as the United States, the solar energy can be a solution for the air quality improvement, the greenhouse gases fight and the reduction of the dependence to the imported petroleum and also for the economic growth by the increase of the employment in the solar industry sector. This document takes stock on the photovoltaic in the United States in the industrial and research domains. The american photovoltaic industry is the third behind the Japan and the Germany. (A.L.B.)

  6. Identified metabolic signature for assessing red blood cell unit quality is associated with endothelial damage markers and clinical outcomes

    Bordbar, Aarash; Johansson, Pär I.; Paglia, Giuseppe

    2016-01-01

    shown no difference of clinical outcome for patients receiving old or fresh RBCs. An overlooked but essential issue in assessing RBC unit quality and ultimately designing the necessary clinical trials is a metric for what constitutes an old or fresh RBC unit. STUDY DESIGN AND METHODS: Twenty RBC units...... years and endothelial damage markers in healthy volunteers undergoing autologous transfusions. CONCLUSION: The state of RBC metabolism may be a better indicator of cellular quality than traditional hematologic variables....

  7. Worldwide research productivity in the field of endocrinology and metabolism--a bibliometric analysis.

    Zhao, Xiyan; Ye, Ru; Zhao, Linhua; Lin, Yiqun; Huang, Wenjing; He, Xinhui; Lian, Fengmei; Tong, Xiaolin

    2015-01-01

    Recently, significant contributions to the study of endocrinology and metabolism have been made. The national contribution, however, has not been reported. The aim of this study was to assess national efforts in the field of endocrinology and metabolism. A Web of Science search was performed using subject categories "endocrinology & metabolism" to identify articles published from 2010 to 2014. The total and per capita numbers of articles and citations were analysed for different countries. A total of 79,394 articles were published on endocrinology and metabolism from 2010 to 2014. Most were published in North America, East Asia, and Europe. The majority (82.28%) were reported by authors in high-income countries, 17.64% were published in middle-income countries, and only 0.08% were published in low-income countries. Authors in the United States published the most articles (27.38%), followed by China (7.22%), Italy (5.70%), the United Kingdom (5.6%), and Japan (5.54%). Articles published by authors in the United States had the most citations (260,934). A positive correlation was found between the number of publications and population/gross domestic product (GDP; p endocrinology and metabolism articles were published by authors from high-income countries with few from low-income countries. The United States was the most productive country. However, when population size and GDP were considered, some European countries were ranked higher.

  8. Science Policy Research Unit annual report 1984/1985

    1984-01-01

    The report covers the principal research programmes of the Unit, and also describes its graduate and undergraduate teaching, (listing subjects of postgraduate research) and library services. A list of 1984 published papers and staff is presented. The principle research programmes include: the setting up of the Designated Research Centre on Science, Technology and Energy Policy in British Economic Development; policy for technology and industrial innovation in industrialised countries; energy economics, technology and policy (with a sub-section on coal); European science and industrial policy; science policy and research evaluation; technical change and employment opportunities in the UK economy; new technology, manpower and skills; technology and social change; science and technology policy in developing countries; military technology and arms limitation. Short-term projects and consultancy are also covered.

  9. Metabolic syndrome is associated with exposure to organochlorine pesticides in Anniston, AL, United States☆

    Rosenbaum, Paula F.; Weinstock, Ruth S.; Silverstone, Allen E.; Sjödin, Andreas; Pavuk, Marian

    2017-01-01

    The Anniston Community Health Survey, a cross-sectional study, was undertaken in 2005–2007 to study environmental exposure to polychlorinated biphenyl (PCB) and organochlorine (OC) pesticides and health outcomes among residents of Anniston, AL, United States. The examination of potential risks between these pollutants and metabolic syndrome, a cluster of cardiovascular risk factors (i.e., hypertension, central obesity, dyslipidemia and dysglycemia) was the focus of this analysis. Participants were 548 adults who completed the survey and a clinic visit, were free of diabetes, and had a serum sample for clinical laboratory parameters as well as PCB and OC pesticide concentrations. Associations between summed concentrations of 35 PCB congeners and 9 individual pesticides and metabolic syndrome were examined using generalized linear modeling and logistic regression; odds ratios (OR) and 95% confidence intervals (CI) are reported. Pollutants were evaluated as quintiles and as log transformations of continuous serum concentrations. Participants were mostly female (68%) with a mean age (SD) of 53.6 (16.2) years. The racial distribution was 56% white and 44% African American; 49% met the criteria for metabolic syndrome. In unadjusted logistic regression, statistically significant and positive associations across the majority of quintiles were noted for seven individually modeled pesticides (p,p′-DDT, p,p′-DDE, HCB, β-HCCH, oxychlor, tNONA, Mirex). Following adjustment for covariables (i.e., age, sex, race, education, marital status, current smoking, alcohol consumption, positive family history of diabetes or cardiovascular disease, liver disease, BMI), significant elevations in risk were noted for p,p′-DDT across multiple quintiles (range of ORs 1.61 to 2.36), for tNONA (range of ORs 1.62–2.80) and for p,p′-DDE [OR (95% CI)] of 2.73 (1.09–6.88) in the highest quintile relative to the first. Significant trends were observed in adjusted logistic models for log

  10. Metabolic syndrome is associated with exposure to organochlorine pesticides in Anniston, AL, United States.

    Rosenbaum, Paula F; Weinstock, Ruth S; Silverstone, Allen E; Sjödin, Andreas; Pavuk, Marian

    2017-11-01

    The Anniston Community Health Survey, a cross-sectional study, was undertaken in 2005-2007 to study environmental exposure to polychlorinated biphenyl (PCB) and organochlorine (OC) pesticides and health outcomes among residents of Anniston, AL, United States. The examination of potential risks between these pollutants and metabolic syndrome, a cluster of cardiovascular risk factors (i.e., hypertension, central obesity, dyslipidemia and dysglycemia) was the focus of this analysis. Participants were 548 adults who completed the survey and a clinic visit, were free of diabetes, and had a serum sample for clinical laboratory parameters as well as PCB and OC pesticide concentrations. Associations between summed concentrations of 35 PCB congeners and 9 individual pesticides and metabolic syndrome were examined using generalized linear modeling and logistic regression; odds ratios (OR) and 95% confidence intervals (CI) are reported. Pollutants were evaluated as quintiles and as log transformations of continuous serum concentrations. Participants were mostly female (68%) with a mean age (SD) of 53.6 (16.2) years. The racial distribution was 56% white and 44% African American; 49% met the criteria for metabolic syndrome. In unadjusted logistic regression, statistically significant and positive associations across the majority of quintiles were noted for seven individually modeled pesticides (p,p'-DDT, p,p'-DDE, HCB, β-HCCH, oxychlor, tNONA, Mirex). Following adjustment for covariables (i.e., age, sex, race, education, marital status, current smoking, alcohol consumption, positive family history of diabetes or cardiovascular disease, liver disease, BMI), significant elevations in risk were noted for p,p'-DDT across multiple quintiles (range of ORs 1.61 to 2.36), for tNONA (range of ORs 1.62-2.80) and for p,p'-DDE [OR (95% CI)] of 2.73 (1.09-6.88) in the highest quintile relative to the first. Significant trends were observed in adjusted logistic models for log 10 HCB [OR=6

  11. [General practice research units in Denmark: multidisciplinary research in support of practical work].

    Reventlow, Susanne; Broholm, Katalin Alexa Király; Mäkelä, Marjukka

    2014-01-01

    In Denmark the general practice research units operating in connection with universities provide a home base, training and methodology support for researchers in the field from medical students to general practitioners carrying out practical work. Research issues frequently require a multidisciplinary approach and use of different kinds of materials. Problems arising from the practical work of general practitioners take priority in the wide selection of topics. The units have networked efficiently with organizations of general practitioners and medical education. The combination of research environments has created synergy benefiting everybody and increased the scientific productivity and visibility of the field.

  12. Application of research findings and summary of research needs: Bud Britton Memorial Symposium on Metabolic Disorders of Feedlot Cattle.

    Galyean, M L; Eng, K S

    1998-01-01

    Updated research findings with acidosis, feedlot bloat, liver abscesses, and sudden death syndromes were presented at the Bud Britton Memorial Symposium on Metabolic Disorders of Feedlot Cattle. Possible industry applications include the need to establish guidelines for use of clostridial vaccines in feedlot cattle, further assessment of the relationship between acidosis and polioencephalomalacia, examination of the effects of various ionophores on the incidence of metabolic disorders, and evaluation of the effects of feed bunk management and limit- and restricted-feeding programs on the incidence of metabolic disorders. A multidisciplinary approach among researchers, consulting nutritionists and veterinarians, and feedlot managers will be required for effective progress in research and in the application of research findings. Areas suggested for further research include 1) assessment of feed consumption patterns and social behavior of cattle in large-pen, feedlot settings; 2) evaluation of the relationship between feed intake management systems (feed bunk management programs, limit- and programmed-feeding) and the incidence of metabolic disorders, including delineation of the role of variability in feed intake in the etiology of such disorders; 3) efforts to improve antemortem and postmortem diagnosis, and to establish standardized regional or national epidemiological databases for various metabolic disorders; 4) ascertaining the accuracy of diagnosis of metabolic disorders and determining the relationship of previous health history of animals to the incidence of metabolic disorders; 5) further defining ruminal and intestinal microbiology as it relates to metabolic disorders and deeper evaluation of metabolic changes that occur with such disorders; 6) continued appraisal of the effects of grain processing and specific feed ingredients and nutrients on metabolic disorders, and development of new feed additives to control or prevent these disorders; and 7

  13. The aging of biomedical research in the United States.

    Kirstin R W Matthews

    Full Text Available In the past 30 years, the average age of biomedical researchers has steadily increased. The average age of an investigator at the National Institutes of Health (NIH rose from 39 to 51 between 1980 and 2008. The aging of the biomedical workforce was even more apparent when looking at first-time NIH grantees. The average age of a new investigator was 42 in 2008, compared to 36 in 1980. To determine if the rising barriers at NIH for entry in biomedical research might impact innovative ideas and research, we analyzed the research and publications of Nobel Prize winners from 1980 to 2010 to assess the age at which their pioneering research occurred. We established that in the 30-year period, 96 scientists won the Nobel Prize in medicine or chemistry for work related to biomedicine, and that their groundbreaking research was conducted at an average age of 41-one year younger than the average age of a new investigator at NIH. Furthermore, 78% of the Nobel Prize winners conducted their research before the age of 51, the average age of an NIH principal investigator. This suggested that limited access to NIH might inhibit research potential and novel projects, and could impact biomedicine and the next generation scientists in the United States.

  14. Closing Symposium of the DFG Research Unit FOR 1066

    Niehuis, Reinhard; Kroll, Norbert; Behrends, Kathrin

    2016-01-01

    The book reports on advanced solutions to the problem of simulating wing and nacelle stall, as presented and discussed by internationally recognized researchers at the Closing Symposium of the DFG Research Unit FOR 1066. Reliable simulations of flow separation on airfoils, wings and powered engine nacelles at high Reynolds numbers represent great challenges in defining suitable mathematical models, computing numerically accurate solutions and providing comprehensive experimental data for the validation of numerical simulations. Additional problems arise from the need to consider airframe-engine interactions and inhomogeneous onset flow conditions, as real aircraft operate in atmospheric environments with often-large distortions. The findings of fundamental and applied research into these and other related issues are reported in detail in this book, which targets all readers, academics and professionals alike, interested in the development of advanced computational fluid dynamics modeling for the simulation of...

  15. A high arctic experience of uniting research and monitoring

    Schmidt, Niels Martin; Christensen, Torben R.; Roslin, Tomas

    2017-07-01

    Monitoring is science keeping our thumb on the pulse of the environment to detect any changes of concern for societies. Basic science is the question-driven search for fundamental processes and mechanisms. Given the firm root of monitoring in human interests and needs, basic sciences have often been regarded as scientifically "purer"—particularly within university-based research communities. We argue that the dichotomy between "research" and "monitoring" is an artificial one, and that this artificial split clouds the definition of scientific goals and leads to suboptimal use of resources. We claim that the synergy between the two scientific approaches is well distilled by science conducted under extreme logistic constraints, when scientists are forced to take full advantage of both the data and the infrastructure available. In evidence of this view, we present our experiences from two decades of uniting research and monitoring at the remote research facility Zackenberg in High Arctic Greenland. For this site, we show how the combination of insights from monitoring with the mechanistic understanding obtained from basic research has yielded the most complete understanding of the system—to the benefit of all, and as an example to follow. We therefore urge scientists from across the continuum from monitoring to research to come together, to disregard old division lines, and to work together to expose a comprehensive picture of ecosystem change and its consequences.

  16. Radioactivity and United Kingdom estuaries: an overview identifying research priorities

    Hamilton, E.I.; Clifton, R.J.; Stevens, H.E.

    1985-05-01

    The report consists of the results of an evaluation of research priorities for the environmental radioactivity of estuaries, (and near shore waters) of the United Kingdom. The format of this report is:(i) general conclusions for the future requirements for research in the field of environmental radioactivity; (ii) an overview of some specific recommendations for research; and (iii) an appendix in which a comprehensive evaluation of the research priorities for specific areas of research are given. On the basis that man is the prime target for concern and protection, special attention has been given to the environment in the vicinity of the British Nuclear Fuels (BNFL) reprocessing plant at Sellafield, Cumbria, which is the source of major releases of a variety of radionuclides into the natural environment. Subjects covered in the Appendix are: site factors; pathways to man; source term; hot particles; terrestrial inputs; surveys and monitoring; analysis; organics; field versus laboratory data; biology; bioaccumulation factors; some bioaccumulators of radioactivity; bioturbation; bacteria; genetics; natural change; sediment; resuspension; surfaces; Ksub(d) factors; pore liquids; diagenesis and the ageing processes; airborne transport of radionuclides; models; natural radioactivity; public opinion; recreation; the ICRP; the ALARA principle; decommissioning of nuclear power stations; identification of research requirements; environmental radioactivity - the national effort. (U.K.)

  17. The United States of America and scientific research.

    Gregory J Hather

    2010-08-01

    Full Text Available To gauge the current commitment to scientific research in the United States of America (US, we compared federal research funding (FRF with the US gross domestic product (GDP and industry research spending during the past six decades. In order to address the recent globalization of scientific research, we also focused on four key indicators of research activities: research and development (R&D funding, total science and engineering doctoral degrees, patents, and scientific publications. We compared these indicators across three major population and economic regions: the US, the European Union (EU and the People's Republic of China (China over the past decade. We discovered a number of interesting trends with direct relevance for science policy. The level of US FRF has varied between 0.2% and 0.6% of the GDP during the last six decades. Since the 1960s, the US FRF contribution has fallen from twice that of industrial research funding to roughly equal. Also, in the last two decades, the portion of the US government R&D spending devoted to research has increased. Although well below the US and the EU in overall funding, the current growth rate for R&D funding in China greatly exceeds that of both. Finally, the EU currently produces more science and engineering doctoral graduates and scientific publications than the US in absolute terms, but not per capita. This study's aim is to facilitate a serious discussion of key questions by the research community and federal policy makers. In particular, our results raise two questions with respect to: a the increasing globalization of science: "What role is the US playing now, and what role will it play in the future of international science?"; and b the ability to produce beneficial innovations for society: "How will the US continue to foster its strengths?"

  18. The United States of America and scientific research.

    Hather, Gregory J; Haynes, Winston; Higdon, Roger; Kolker, Natali; Stewart, Elizabeth A; Arzberger, Peter; Chain, Patrick; Field, Dawn; Franza, B Robert; Lin, Biaoyang; Meyer, Folker; Ozdemir, Vural; Smith, Charles V; van Belle, Gerald; Wooley, John; Kolker, Eugene

    2010-08-16

    To gauge the current commitment to scientific research in the United States of America (US), we compared federal research funding (FRF) with the US gross domestic product (GDP) and industry research spending during the past six decades. In order to address the recent globalization of scientific research, we also focused on four key indicators of research activities: research and development (R&D) funding, total science and engineering doctoral degrees, patents, and scientific publications. We compared these indicators across three major population and economic regions: the US, the European Union (EU) and the People's Republic of China (China) over the past decade. We discovered a number of interesting trends with direct relevance for science policy. The level of US FRF has varied between 0.2% and 0.6% of the GDP during the last six decades. Since the 1960s, the US FRF contribution has fallen from twice that of industrial research funding to roughly equal. Also, in the last two decades, the portion of the US government R&D spending devoted to research has increased. Although well below the US and the EU in overall funding, the current growth rate for R&D funding in China greatly exceeds that of both. Finally, the EU currently produces more science and engineering doctoral graduates and scientific publications than the US in absolute terms, but not per capita. This study's aim is to facilitate a serious discussion of key questions by the research community and federal policy makers. In particular, our results raise two questions with respect to: a) the increasing globalization of science: "What role is the US playing now, and what role will it play in the future of international science?"; and b) the ability to produce beneficial innovations for society: "How will the US continue to foster its strengths?"

  19. Elucidation of primary metabolic pathways in Aspergillus species: orphaned research in characterizing orphan genes.

    Andersen, Mikael Rørdam

    2014-11-01

    Primary metabolism affects all phenotypical traits of filamentous fungi. Particular examples include reacting to extracellular stimuli, producing precursor molecules required for cell division and morphological changes as well as providing monomer building blocks for production of secondary metabolites and extracellular enzymes. In this review, all annotated genes from four Aspergillus species have been examined. In this process, it becomes evident that 80-96% of the genes (depending on the species) are still without verified function. A significant proportion of the genes with verified metabolic functions are assigned to secondary or extracellular metabolism, leaving only 2-4% of the annotated genes within primary metabolism. It is clear that primary metabolism has not received the same attention in the post-genomic area as many other research areas--despite its role at the very centre of cellular function. However, several methods can be employed to use the metabolic networks in tandem with comparative genomics to accelerate functional assignment of genes in primary metabolism. In particular, gaps in metabolic pathways can be used to assign functions to orphan genes. In this review, applications of this from the Aspergillus genes will be examined, and it is proposed that, where feasible, this should be a standard part of functional annotation of fungal genomes. © The Author 2014. Published by Oxford University Press.

  20. Clinical research of bone scan characteristics for metabolic bone diseases

    Zhu Ruisen; Luo Qiong; Lu Haikui; Chen Libo; Luo Quanyong

    2009-01-01

    Characteristic images of 99m Tc-MDP bone scintigraphy in patients with metabolic bone diseases (MBD) were analyzed and compared, in an attempt to improve the capability of differential diagnosis in this aspect. A total of 142 cases, clinically confirmed as (MBD), were categorized into six groups: hyperparathyroidism (117), renal osteodystrophy (4), Paget's disease (16), hypophosphatemic osteomalacia (2), Albers-Schonberg disease (2), and Brittle bone disease (1). They were diagnosed clinically or pathologically, and scanned with 99m Tc-MDP bone scintegraphy, from which the 142 MBD cases were classified into 4 types. The cases of Type I had increased amount of 99m Tc-MDP uptake in whole body bones, including hyperparathyroidism, Albers-Schonberg disease, brittle bone disease and renal osteodystrophy. The cases of Type II had high uptake of 99m Tc-MDP in local region of bones, including paget's disease, hypophosphatemic osteomalacia and hyperparathyroidism. A Type I case with pathological fracture or secondary osteopathy was classified as Type III. Type IV cases were in early stage of hyperparathyroidism, with normal bone scan image. Analysis of the characteristics of 99m Tc-MDP bone scintigraphic findings (locations, morphology and intensities) in patients with MBD may be helpful in the differential diagnosis of MBD, in association with the patient's history and X-ray data altogether. (authors)

  1. Exploring the SCOAP3 Research Contributions of the United States

    Marsteller, Matthew

    2016-03-01

    The Sponsoring Consortium for Open Access Publishing in Particle Physics (SCOAP3) is a successful global partnership of libraries, funding agencies and research centers. This presentation will inform the audience about SCOAP3 and also delve into descriptive statistics of the United States' intellectual contribution to particle physics via these open access journals. Exploration of the SCOAP3 particle physics literature using a variety of metrics tools such as Web of Science™, InCites™, Scopus® and SciVal will be shared. ORA or Sci2 will be used to visualize author collaboration networks.

  2. RESEARCH ARTICLE Genetic analysis of drug-metabolizing phase ...

    Navya

    Sorting intolerant from tolerant (SIFT) (http://sift.bii.a-star.edu.sg/) and .... science and technology research projects of Xizang (Tibet) Autonomous Region ..... color schemes, with bright red for very strong LD (LOD > 2, D'= 1), pink red (LOD >.

  3. 2009 Plant Lipids: Structure, Metabolism & Function Gordon Research Conference - February 1- 6 ,2009

    Kent D. Chapman

    2009-02-06

    The Gordon Research Conference on 'Plant Lipids: Structure, Metabolism and Function' has been instituted to accelerate research productivity in the field of plant lipids. This conference will facilitate wide dissemination of research breakthroughs, support recruitment of young scientists to the field of plant lipid metabolism and encourage broad participation of the plant lipid community in guiding future directions for research in plant lipids. This conference will build upon the strengths of the successful, previous biannual meetings of the National Plant Lipid Cooperative (www.plantlipids.org) that began in 1993, but will reflect a broader scope of topics to include the biochemistry, cell biology, metabolic regulation, and signaling functions of plant acyl lipids. Most importantly, this conference also will serve as a physical focal point for the interaction of the plant lipid research community. Applications to attend this conference will be open to all researchers interested in plant lipids and will provide a venue for the presentation of the latest research results, networking opportunities for young scientists, and a forum for the development and exchange of useful lipid resources and new ideas. By bringing together senior- and junior-level scientists involved in plant lipid metabolism, a broad range of insights will be shared and the community of plant lipid researchers will function more as a network of vested partners. This is important for the vitality of the research community and for the perceived value that will encourage conference attendance into the future.

  4. Directions of ICF research in the United States

    Hogan, W.J.; Campbell, E.M.

    1997-01-01

    Inertial confinement fusion (ICF) research in the United States is in a dramatic upswing. Technical progress continues at a rapid pace and with the start of the construction of the National Ignition Facility (NIF) this year the total U.S. budget for ICF for fiscal year 1997 stands at $380 million. The NIF is being built as an essential component of the U.S. Stockpile Stewardship and Management Program which has been formulated to assure the continued safety, reliability, and performance of the downsized nuclear weapons stockpile in the absence of nuclear tests. This paper will discuss some of the directions that the ICF research is now taking. (AIP) copyright 1997 American Institute of Physics

  5. United States Domestic Research Reactor Infrastructure - TRIGA Reactor Fuel Support

    Morrell, Douglas

    2008-01-01

    The purpose of the United State Domestic Research Reactor Infrastructure Program is to provide fresh nuclear reactor fuel to United States universities at no, or low, cost to the university. The title of the fuel remains with the United States government and when universities are finished with the fuel, the fuel is returned to the United States government. The program is funded by the United States Department of Energy - Nuclear Energy division, managed by Department of Energy - Idaho Field Office, and contracted to the Idaho National Laboratory's Management and Operations Contractor - Battelle Energy Alliance. Program has been at Idaho since 1977 and INL subcontracts with 26 United States domestic reactor facilities (13 TRIGA facilities, 9 plate fuel facilities, 2 AGN facilities, 1 Pulstar fuel facility, 1 Critical facility). University has not shipped fuel since 1968 and as such, we have no present procedures for shipping spent fuel. In addition: floor loading rate is unknown, many interferences must be removed to allow direct access to the reactor tank, floor space in the reactor cell is very limited, pavement ends inside our fence; some of the surface is not finished. The whole approach is narrow, curving and downhill. A truck large enough to transport the cask cannot pull into the lot and then back out (nearly impossible / refused by drivers); a large capacity (100 ton), long boom crane would have to be used due to loading dock obstructions. Access to the entrance door is on a sidewalk. The campus uses it as a road for construction equipment, deliveries and security response. Large trees are on both sides of sidewalk. Spent fuel shipments have never been done, no procedures approved or in place, no approved casks, no accident or safety analysis for spent fuel loading. Any cask assembly used in this facility will have to be removed from one crane, moved on the floor and then attached to another crane to get from the staging area to the reactor room. Reactor

  6. Molecular image in biomedical research. Molecular imaging unit of the National Cancer Research Center

    Perez Bruzon, J.; Mulero Anhiorte, F.

    2010-01-01

    This article has two basic objectives. firstly, it will review briefly the most important imaging techniques used in biomedical research indicting the most significant aspects related to their application in the preclinical stage. Secondly, it will present a practical application of these techniques in a pure biomedical research centre (not associated to a clinical facility). Practical aspects such as organisation, equipment, work norms, shielding of the Spanish National Cancer Research Centre (CNIO) Imaging Unit will be shown. This is a pioneering facility in the application of these techniques in research centres without any dependence or any direct relationship with other hospital Nuclear Medicine services. (Author) 7 refs.

  7. Toxic Hazards Research Unit Annual Report (26th) (1989)

    1990-10-01

    enzymes involved in fatty acid metabolism In the absence of a significant degree of enzyme indluction, compounds such as clofibrate and di(2.erthylhoxyl...or chlorotrifluoroethylene oligomers and the acid metabolic products of this hydraulic fluid material. Initial acute studies also were conducted on a...Perhalocarboxylic Acids Physiologically Based Pharniacokinetic Model Polychiorotrifluoroethylene Silahydrocarbon Triethylborane Trimethy lol propane Phosphate

  8. 2001 Gordon Research Conference on Archaea: Ecology [sic], Metabolism. Final progress report [agenda and attendee list

    Daniels, Charles

    2001-08-10

    The Gordon Research Conference on Archaea: Ecology, Metabolism [and Molecular Biology] was held at Proctor Academy, Andover, New Hampshire, August 5-10, 2001. The conference was attended by 135 participants. The attendees represented the spectrum of endeavor in this field, coming from academia, industry, and government laboratories, and included US and foreign scientists, senior researchers, young investigators, and students. Emphasis was placed on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate discussion about the key issues in the field today. Session topics included the following: Ecology and genetic elements; Genomics and evolution; Ecology, genomes and gene regulation; Replication and recombination; Chromatin and transcription; Gene regulation; Post-transcription processing; Biochemistry and metabolism; Proteomics and protein structure; Metabolism and physiology. The featured speaker addressed the topic: ''Archaeal viruses, witnesses of prebiotic evolution?''

  9. On the use of a continuous metabolic syndrome score in pediatric research

    Eisenmann Joey C

    2008-06-01

    Full Text Available Abstract Background The constellation of elevated levels of abdominal adiposity, blood pressure, glucose, and triglycerides and lowered high-density lipoprotein-cholesterol has been termed the metabolic syndrome. Given the current pediatric obesity epidemic, it is perhaps not surprising that recent reports suggest the emergence of the metabolic syndrome during childhood and adolescence. The aim of this paper is to provide an overview of the derivation and utility of the continuous metabolic syndrome score in pediatric epidemiologic research. Methods/Design Data were generated from published papers related to the topic. Conclusion Although there is no universal definition in children or adolescence, recent estimates indicate that approximately 2–10% of youth possess the metabolic syndrome phenotype. Since there is no clear definition and the prevalence rate is relatively low, several authors have derived a continuous score representing a composite risk factor index (i.e., the metabolic syndrome score. This paper provides an overview of the derivation and utility of the continuous metabolic syndrome score in pediatric epidemiological research.

  10. Stress, autonomic imbalance, and the prediction of metabolic risk: A model and a proposal for research.

    Wulsin, Lawson; Herman, James; Thayer, Julian F

    2018-03-01

    Devising novel prevention strategies for metabolic disorders will depend in part on the careful elucidation of the common pathways for developing metabolic risks. The neurovisceral integration model has proposed that autonomic imbalance plays an important role in the pathway from acute and chronic stress to cardiovascular disease. Though generally overlooked by clinicians, autonomic imbalance (sympathetic overactivity and/or parasympathetic underactivity) can be measured and modified by methods that are available in primary care. This review applies the neurovisceral integration concept to the clinical setting by proposing that autonomic imbalance plays a primary role in the development of metabolic risks. We present a testable model, a systematic review of the evidence in support of autonomic imbalance as a predictor for metabolic risks, and specific approaches to test this model as a guide to future research on the role of stress in metabolic disorders. We propose that autonomic imbalance deserves consideration by researchers, clinicians, and policymakers as a target for early interventions to prevent metabolic disorders. Published by Elsevier Ltd.

  11. RNA sequencing: current and prospective uses in metabolic research.

    Vikman, Petter; Fadista, Joao; Oskolkov, Nikolay

    2014-10-01

    Previous global RNA analysis was restricted to known transcripts in species with a defined transcriptome. Next generation sequencing has transformed transcriptomics by making it possible to analyse expressed genes with an exon level resolution from any tissue in any species without any a priori knowledge of which genes that are being expressed, splice patterns or their nucleotide sequence. In addition, RNA sequencing is a more sensitive technique compared with microarrays with a larger dynamic range, and it also allows for investigation of imprinting and allele-specific expression. This can be done for a cost that is able to compete with that of a microarray, making RNA sequencing a technique available to most researchers. Therefore RNA sequencing has recently become the state of the art with regards to large-scale RNA investigations and has to a large extent replaced microarrays. The only drawback is the large data amounts produced, which together with the complexity of the data can make a researcher spend far more time on analysis than performing the actual experiment. © 2014 Society for Endocrinology.

  12. Research in the United States relative to geochemistry and health

    Petrie, W.L.; Cannon, H.L.

    1979-01-01

    Increasing concern regarding the effects of the geochemical environment on health in the United States has fostered research studies in a number of universities and government agencies. The necessity to evaluate the effects of natural and man-made elemental excesses in the environment on health requires the establishment of requirements and tolerance limits for the various elements in water and crops. Maps of the geographic distribution of these elements in rocks, surficial materials and ground and surface waters are also essential for comparison with the occurrence of disease. Funding support for research projects that relate to various parameters of these problems emanates largely from a few federal agencies, and much of the work is conducted at government, university and private facilities. An example of the latter is the National Academy of Sciences-National Research Council, which has several components that are addressing a variety of comparative studies of the geochemical environment related to health; studies involve specific trace elements (like selenium and magnesium), diseases (like cancer, urolithiasis and cardiovascular disease), other health factors (like aging and nutrition) and links with timely major problems (like the health effects of greatly increasing the use of coal). ?? 1979.

  13. Prevalence and component analysis of metabolic syndrome: An Indian atherosclerosis research study perspective

    Saikat Kanjilal

    2008-02-01

    Full Text Available Saikat Kanjilal3, Jayashree Shanker1, Veena S Rao2, Natesha B Khadrinarasimhaih2, Manjari Mukherjee4, Shamanna S Iyengar3, Vijay V Kakkar1,51Mary and Garry Weston Functional Genomics Unit, Thrombosis Research Institute, Bangalore, India; 2Tata Proteomics and Coagulation Unit, Thrombosis Research Institute, Bangalore, India; 3Division of Cardiology, St. Johns Medical College and Hospital, Bangalore, India; 4University Department of Chemical Technology, Mumbai, India; 5Thrombosis Research Institute, Chelsea, London, UKAbstract: Asian Indians have a high predisposition to metabolic syndrome (MS and coronary artery disease (CAD. The present study aimed to estimate MS prevalence in 531 Asian Indian families comprising of 2318 individuals. Anthropometrics and lipid profile were assessed. MS prevalence was estimated using standard Adult Treatment Panel III (ATP-III and World Health Organisation (WHO criteria and modified definitions which included lowered cut-offs for waist circumference (WC (≥90 cm for men and ≥80 cm for women], body mass index (BMI (≥23 kg/m2 and impaired fasting glucose (IFG levels. ATP-III criteria identified a significantly higher proportion of people with MS (N = 933; 40.3% compared with WHO (N = 708; 30.6%; p<0.0001 while modified ATP-III showed maximum gain in percent prevalence among the revised criteria (17.3%; p = 0.0056. The IDF criteria identified similar proportion of subjects with MS (N = 809; 34.9% as the revised WHO criteria (N = 792; 34.2%. The number of MS subjects was highest in the 50–59 years age group. MS was diagnosed a decade earlier in unaffected subjects compared with those with CAD/diabetes using the modified MS criteria. WC correlated significantly with BMI and waist–hip ratio (WHR (p = 0.000. Among MS components, high density lipoprotein cholesterol and BMI contributed significantly in males (71.4% and 85.9% and females (86.8% and 88.8%, respectively. The higher percentage contribution of WC

  14. Status of reactor shielding research in the United States

    Bartine, D.E.

    1983-01-01

    Shielding research in the United States continues to place emphasis on: (1) the development and refinement of shielding design calculational methods and nuclear data; and (2) the performance of confirmation experiments, both to evaluate specific design concepts and to verify specific calculational techniques and input data. The successful prediction of the radiation levels observed within the now-operating Fast Flux Test Facility (FFTF) has demonstrated the validity of this two-pronged approach, which has since been applied to US fast breeder reactor programs and is now being used to determine radiation levels and possible further shielding needs at operating light water reactors, especially under accident conditions. A similar approach is being applied to the back end of the fission fuel cycle to verify that radiation doses at fuel element storage and transportation facilities and within fuel reprocessing plants are kept at acceptable levels without undue economic penalties

  15. Public and nonprofit funding for research on mental disorders in France, the United Kingdom, and the United States.

    Chevreul, Karine; McDaid, David; Farmer, Carrie M; Prigent, Amélie; Park, A-La; Leboyer, Marion; Kupfer, David J; Durand-Zaleski, Isabelle

    2012-07-01

    To document the investments made in research on mental disorders by both government and nonprofit nongovernmental organizations in France, the United Kingdom, and the United States. An exhaustive survey was conducted of primary sources of public and nonprofit organization funding for mental health research for the year 2007 in France and the United Kingdom and for fiscal year 2007-2008 in the United States, augmented with an examination of relevant Web sites and publications. In France, all universities and research institutions were identified using the Public Finance Act. In the United Kingdom, we scrutinized Web sites and hand searched annual reports and grant lists for the public sector and nonprofit charitable medical research awarding bodies. In the United States, we included the following sources: the National Institutes of Health, other administrative entities within the Department of Health and Human Services (eg, Centers for Disease Control and Prevention), the Department of Education, the Department of Veterans Affairs, the Department of Defense, and the National Science Foundation and, for nonprofit funding, The Foundation Center. We included research on all mental disorders and substance-related disorders using the same keywords. We excluded research on mental retardation and dementia and on the promotion of mental well-being. We used the same algorithm in each country to obtain data for only mental health funding in situations in which funding had a broader scope. France spent $27.6 million (2%) of its health research budget on mental disorders, the United Kingdom spent $172.6 million (7%), and the United States spent $5.2 billion (16%). Nongovernmental funding ranged from 1% of total funding for mental health research in France and the United States to 14% in the United Kingdom. Funding for research on mental disorders accounts for low proportions of research budgets compared with funding levels for research on other major health problems, whereas

  16. Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure

    Kit-Yi Leung

    2017-11-01

    Full Text Available Summary: Abnormal folate one-carbon metabolism (FOCM is implicated in neural tube defects (NTDs, severe malformations of the nervous system. MTHFR mediates unidirectional transfer of methyl groups from the folate cycle to the methionine cycle and, therefore, represents a key nexus in partitioning one-carbon units between FOCM functional outputs. Methionine cycle inhibitors prevent neural tube closure in mouse embryos. Similarly, the inability to use glycine as a one-carbon donor to the folate cycle causes NTDs in glycine decarboxylase (Gldc-deficient embryos. However, analysis of Mthfr-null mouse embryos shows that neither S-adenosylmethionine abundance nor neural tube closure depend on one-carbon units derived from embryonic or maternal folate cycles. Mthfr deletion or methionine treatment prevents NTDs in Gldc-null embryos by retention of one-carbon units within the folate cycle. Overall, neural tube closure depends on the activity of both the methionine and folate cycles, but transfer of one-carbon units between the cycles is not necessary. : Leung at al. find that embryonic neural tube closure depends both on the supply of one-carbon units to the folate cycle from glycine cleavage and on the methionine cycle. In contrast, transfer of one-carbon units from the folate cycle to the methionine cycle by MTHFR is dispensable. Keywords: one-carbon metabolism, folic acid, neural tube defects, spina bifida, glycine cleavage system, non-ketotic hyperglycinemia, eye, Mthfr, Gldc

  17. What is Metabolic Syndrome?

    ... Intramural Research Home / Metabolic Syndrome Metabolic Syndrome Also known as What Is Metabolic syndrome ... metabolic risk factors to be diagnosed with metabolic syndrome. Metabolic Risk Factors A Large Waistline Having a large ...

  18. Cryopreservation of Precision-cut Tissue Slices for Application in Drug Metabolism Research

    Graaf, Inge Anne Maria de

    2002-01-01

    The research described in this thesis had two important aims. The first was to determine whether tissue slices could be used as an in vitro tool to predict the in vivo metabolism of new drugs. The second aim was to find a manner to store tissue slices for longer time periods by cryopreservation.

  19. Connecting Arctic Research Across Boundaries through the Arctic Research Consortium of the United States (ARCUS)

    Rich, R. H.; Myers, B.; Wiggins, H. V.; Zolkos, J.

    2017-12-01

    The complexities inherent in Arctic research demand a unique focus on making connections across the boundaries of discipline, institution, sector, geography, knowledge system, and culture. Since 1988, ARCUS has been working to bridge these gaps through communication, coordination, and collaboration. Recently, we have worked with partners to create a synthesis of the Arctic system, to explore the connectivity across the Arctic research community and how to strengthen it, to enable the community to have an effective voice in research funding policy, to implement a system for Arctic research community knowledge management, to bridge between global Sea Ice Prediction Network researchers and the science needs of coastal Alaska communities through the Sea Ice for Walrus Outlook, to strengthen ties between Polar researchers and educators, and to provide essential intangible infrastructure that enables cost-effective and productive research across boundaries. Employing expertise in managing for collaboration and interdisciplinarity, ARCUS complements and enables the work of its members, who constitute the Arctic research community and its key stakeholders. As a member-driven organization, everything that ARCUS does is achieved through partnership, with strong volunteer leadership of each activity. Key organizational partners in the United States include the U.S. Arctic Research Commission, Interagency Arctic Research Policy Committee, National Academy of Sciences Polar Research Board, and the North Slope Science Initiative. Internationally, ARCUS maintains strong bilateral connections with similarly focused groups in each Arctic country (and those interested in the Arctic), as well as with multinational organizations including the International Arctic Science Committee, the Association of Polar Early Career Educators, the University of the Arctic, and the Arctic Institute of North America. Currently, ARCUS is applying the best practices of the science of team science

  20. The Medical Research Council (UK)/Uganda Virus Research Institute Uganda Research Unit on AIDS--'25 years of research through partnerships'.

    Kaleebu, P; Kamali, A; Seeley, J; Elliott, A M; Katongole-Mbidde, E

    2015-02-01

    For the past 25 years, the Medical Research Council/Uganda Virus Research Institute Uganda Research Unit on AIDS has conducted research on HIV-1, coinfections and, more recently, on non-communicable diseases. Working with various partners, the research findings of the Unit have contributed to the understanding and control of the HIV epidemic both in Uganda and globally, and informed the future development of biomedical HIV interventions, health policy and practice. In this report, as we celebrate our silver jubilee, we describe some of these achievements and the Unit's multidisciplinary approach to research. We also discuss the future direction of the Unit; an exemplar of a partnership that has been largely funded from the north but led in the south. © 2014 The Authors. Tropical Medicine & International Health Published by John Wiley & Sons Ltd.

  1. Technology of research of hydroturbine unit work using seismic methods

    Seleznev, V. S.; Liseikin, A. V.; Gromyko, P. V.; Soloviev, V. M.

    2013-05-01

    On August, 17, 2009 one of the most significant accident in hydropower engineering was happened at Sayano-Shushenskaya Hydroelectric Power Station. Specialists of Geophysical Survey SB RAS took part in the State Committee on investigation of the accident cause at Sayano-Shushenskaya HPS. It was determined, that the cause of the accident was a break of stud-bolts on the turbine cover. Why stud-bolts did not stand a load? There were assumptions that hydraulic shock provoked the accident. But, if it is so, seismic station "Cheremushky", situated in 4 km away from the HPS, should has a record of this event. First of all, investigating the record, got at the seismic station in the moment of the accident, it was determined that strength of seismic waves, recorded at the moment of the accident, did not exceed strength of waves got at trotyl explosion of 500 g at a distance to 4 km. The version of hydraulic shock was not proved. There were distinguished low-frequency oscillations and it was determined that the hydroturbine unit (HU) had been raised up more then 10 m in height for 10 sec. Analyzing the seismic station records during the period of more than a year before the accident and records of operating modes of different HU, there was determined that oscillations radiated by second (damaged) HU were approximately 1.5 times more intense than oscillations from all other HU. After the accident at Sayano-Shushenskaya HPS hydroturbine units were started in turns: at first there were started hydroturbine units of old construction (3, 4, 5, 6), then HP of new construction (1, 7, 8, 9). We installed 10 - 15 three-component seismic stations in different points around a HU and studied field of seismic oscillations from it's work. It was determined, that HU radiates a set of monochromatic oscillations divisible by speed of rotation equal to 2.381 Hz. Change of these signals amplitude is connected with change of HU operation modes. Research of changes in oscillations spectral

  2. Medical researchers unite for study on cancer intervention

    Editorial Office

    2016-08-01

    Full Text Available We introduce Drs. Antoine Snijders and Jian-Hua Mao, whose article is published in this issue of AMOR and discuss their views on cancer genetics, targeted therapy, and personalized medicine.Having worked together in numerous joint investigations that have yielded significant results, Dr. Snijders and Dr. Mao would most definitely agree that two heads are better than one. “Researchers these days need to have the ability to collaborate across many different disciplines,” said the duo in an exclusive interview with AMOR. Dr. Snijders and Dr. Mao, both with PhDs in cancer genetics and genomics, are currently based at the Biological Systems and Engineering Division of Lawrence Berkeley National Laboratory, California, which is a member of the national laboratory system supported by the U.S Department of Energy through its Office of Science. The Berkeley Lab is well known for producing excellent scholars, as thirteen Nobel Prize winners are affiliated with the Lab and seventy of its scientists are members of the National Academy of Sciences (NAS, one of the highest honors for a scientist in the United States. Dr. Snijders, a Dutch who has conducted his research at Berkeley Lab for the past eight years, did his Masters in Science (Medical Biology at the Vrije Universiteit Amsterdam, Netherlands – an institute with a strong focus on scientific research and is home to five Spinoza Prize (a.k.a. the “Dutch Nobel” winners. Dr. Snijders’s PhD (cum laude in cancer and molecular biology was awarded by University Utrecht in Netherlands, but his research work was carried out at the University of California San Francisco. Subsequently, he continued his postdoctoral research in molecular cytogenetics at the same institution. A prolific author of 114 publications (with 3,851 citations according to ResearchGate, Dr. Snijders – who also volunteers with California’s Contra Costa County Search and Rescue team for missing persons – has interests in

  3. Changing the Translational Research Landscape: A Review of the Impacts of Biomedical Research Units in England.

    Marjanovic, Sonja; Soper, Bryony; Ismail, Sharif; Reding, Anais; Ling, Tom

    2012-01-01

    This article describes a review of the Biomedical Research Units (BRU) scheme, undertaken for the Department of Health. This review was a perceptions audit of senior executives involved in the scheme, and explored what impact they felt the scheme is having on the translational research landscape. More specifically, we investigated whether and how institutional relationships between NHS and academic partners, industry and other health research system players are changing because of the scheme; how the scheme is helping build critical mass in specific priority disease areas; and the effects of any changes on efforts to deliver the broader goals set out in Best Research for Best Health. The views presented are those of study informants only. The information obtained through our interviews suggests that the BRU scheme is significantly helping shape the health research system to pursue translational research and innovation, with the clear goal of realising patient benefit. The BRUs are already contributing to observable changes in institutional relationships between the NHS and academic partners: trusts and medical schools are collaborating more closely than in the past, have signed up to the same vision of translational research from bench to bedside, and are managing and governing targeted research resources more professionally and transparently than in the past. There is also a stronger emphasis on engaging industry and more strategic thinking about strengthening regional and national collaboration with other hospital trusts, PCTs, research organisations, networks and development agencies. The scheme is also transforming capacity building in the health research system. This includes (i) developing and modernising facilities and equipment for translation; (ii) building a critical mass of human resources through recruitment and training, as well as improving retention of existing expertise; and (iii) helping ensure a steady flow of funds needed to sustain research

  4. Research on Anoplophora glabripennis in the United States

    Robert A. Haack

    2003-01-01

    In the mid-1990s it was estimated that more than 400 exotic (non-native) forest insects had already become established in the United States (HAACK and BYLER, 1993; MATTSON et al., 1994; NIEMELA and MATTSON, 1996). This number has continued to grow with new exotics discovered annually in the United States (HAACK, 2002; HAACK and POLAND, 2001; HAACK et al., 2002). One...

  5. Analysis of Cancer Metabolism by Imaging Hyperpolarized Nuclei: Prospects for Translation to Clinical Research

    John Kurhanewicz

    2011-02-01

    Full Text Available A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo with the goal of improved diagnosis and perhaps therapy. Because of the complexity of biochemical pathways, tracer methods are required for detecting specific enzyme-catalyzed reactions. Stable isotopes such as 13C or 15N with detection by nuclear magnetic resonance provide the necessary information about tissue biochemistry, but the crucial metabolites are present in low concentration and therefore are beyond the detection threshold of traditional magnetic resonance methods. A solution is to improve sensitivity by a factor of 10,000 or more by temporarily redistributing the populations of nuclear spins in a magnetic field, a process termed hyperpolarization. Although this effect is short-lived, hyperpolarized molecules can be generated in an aqueous solution and infused in vivo where metabolism generates products that can be imaged. This discovery lifts the primary constraint on magnetic resonance imaging for monitoring metabolism—poor sensitivity—while preserving the advantage of biochemical information. The purpose of this report was to briefly summarize the known abnormalities in cancer metabolism, the value and limitations of current imaging methods for metabolism, and the principles of hyperpolarization. Recent preclinical applications are described. Hyperpolarization technology is still in its infancy, and current polarizer equipment and methods are suboptimal. Nevertheless, there are no fundamental barriers to rapid translation of this exciting technology to clinical research and perhaps clinical care.

  6. 2012 Molecular Basis of Microbial One-Carbon Metabolism Gordon Research Conferences and Gordon Research Seminar, August 4-10,2012

    Hanson, Thomas

    2012-08-10

    The 2012 Gordon Conference will present and discuss cutting-edge research in the field of microbial metabolism of C1 compounds. The conference will feature the roles and application of C1 metabolism in natural and synthetic systems at scales from molecules to ecosystems. The conference will stress molecular aspects of the unique metabolism exhibited by autotrophic bacteria, methanogens, methylotrophs, aerobic and anaerobic methanotrophs, and acetogens.

  7. 3D intestinal organoids in metabolic research: virtual reality in a dish.

    Tsakmaki, Anastasia; Fonseca Pedro, Patricia; Bewick, Gavin A

    2017-12-01

    The advent of near physiological organoid technology has produced a step change in our understanding of stem cells and has provided the research community with a powerful new cell based tool to model human physiology and disease. We review the pros and cons of intestinal organoid culture systems. The molecular and genetic tools to manipulate them and how they are being used to answer fundamental questions in metabolic research, including the function of enteroendocrine cells in health and disease. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Advantage of Animal Models with Metabolic Flexibility for Space Research Beyond Low Earth Orbit

    Griko, Yuri V.; Rask, Jon C.; Raychev, Raycho

    2017-01-01

    As the worlds space agencies and commercial entities continue to expand beyond Low Earth Orbit (LEO), novel approaches to carry out biomedical experiments with animals are required to address the challenge of adaptation to space flight and new planetary environments. The extended time and distance of space travel along with reduced involvement of Earth-based mission support increases the cumulative impact of the risks encountered in space. To respond to these challenges, it becomes increasingly important to develop the capability to manage an organisms self-regulatory control system, which would enable survival in extraterrestrial environments. To significantly reduce the risk to animals on future long duration space missions, we propose the use of metabolically flexible animal models as pathfinders, which are capable of tolerating the environmental extremes exhibited in spaceflight, including altered gravity, exposure to space radiation, chemically reactive planetary environments and temperature extremes.In this report we survey several of the pivotal metabolic flexibility studies and discuss the importance of utilizing animal models with metabolic flexibility with particular attention given to the ability to suppress the organism's metabolism in spaceflight experiments beyond LEO. The presented analysis demonstrates the adjuvant benefits of these factors to minimize damage caused by exposure to spaceflight and extreme planetary environments. Examples of microorganisms and animal models with dormancy capabilities suitable for space research are considered in the context of their survivability under hostile or deadly environments outside of Earth. Potential steps toward implementation of metabolic control technology in spaceflight architecture and its benefits for animal experiments and manned space exploration missions are discussed.

  9. Reactor aging research. United States Nuclear Regulatory Commission

    Vassilaros, M.G.

    1998-01-01

    The reactor ageing research activities in USA described, are focused on the research of reactor vessel integrity, including regulatory issues and technical aspects. Current emphasis are described for fracture analysis, embrittlement research, inspection capabilities, validation od annealing rule, revision of regulatory guide

  10. Research Note Topographical units and soil types prove more ...

    The floristic data (species presence at each site) were grouped into Land Types, topographical units and broad soil types. Each group was analysed independently using multivariate detrended correspondence analysis (DCA) and the mean similarity test. The floristic data in each Land Type showed a 42% range of ...

  11. Computational fluid dynamics research at the United Technologies Research Center requiring supercomputers

    Landgrebe, Anton J.

    1987-01-01

    An overview of research activities at the United Technologies Research Center (UTRC) in the area of Computational Fluid Dynamics (CFD) is presented. The requirement and use of various levels of computers, including supercomputers, for the CFD activities is described. Examples of CFD directed toward applications to helicopters, turbomachinery, heat exchangers, and the National Aerospace Plane are included. Helicopter rotor codes for the prediction of rotor and fuselage flow fields and airloads were developed with emphasis on rotor wake modeling. Airflow and airload predictions and comparisons with experimental data are presented. Examples are presented of recent parabolized Navier-Stokes and full Navier-Stokes solutions for hypersonic shock-wave/boundary layer interaction, and hydrogen/air supersonic combustion. In addition, other examples of CFD efforts in turbomachinery Navier-Stokes methodology and separated flow modeling are presented. A brief discussion of the 3-tier scientific computing environment is also presented, in which the researcher has access to workstations, mid-size computers, and supercomputers.

  12. Tribal wilderness research needs and issues in the United States and Canada

    Dan McDonald; Tom McDonald; Leo H. McAvoy

    2000-01-01

    This paper represents a dialogue between tribal wilderness managers and researchers on the primary research needs of tribal wilderness in the United States and Canada. The authors identify a number of research priorities for tribal wildlands. The paper also discusses some major issues and challenges faced by researchers conducting research in areas that are culturally...

  13. Inter-relationships between single carbon units' metabolism and resting energy expenditure in weight-losing patients with small cell lung cancer. Effects of methionine supply and chemotherapy

    Sengeløv, H; Hansen, O P; Simonsen, L

    1994-01-01

    The one-carbon unit metabolism was investigated in 8 weight-losing patients with small cell carcinoma of the lung (SCLC). At diagnosis, 6 of the 8 patients had elevated formiminoglutamic acid (FIGLU) excretion after a histidine load, suggesting a lack of one-carbon units. In accordance...

  14. Inter-relationships between single carbon units' metabolism and resting energy expenditure in weight-losing patients with small cell lung cancer. Effects of methionine supply and chemotherapy

    Sengeløv, H; Hansen, O P; Simonsen, L

    1994-01-01

    The one-carbon unit metabolism was investigated in 8 weight-losing patients with small cell carcinoma of the lung (SCLC). At diagnosis, 6 of the 8 patients had elevated formiminoglutamic acid (FIGLU) excretion after a histidine load, suggesting a lack of one-carbon units. In accordance, a signifi...

  15. Key considerations for the success of Medical Education Research and Innovation units in Canada: unit director perceptions.

    Varpio, Lara; Bidlake, Erin; Humphrey-Murto, Sue; Sutherland, Stephanie; Hamstra, Stanley J

    2014-08-01

    Growth in the field of medical education is evidenced by the proliferation of units dedicated to advancing Medical Education Research and Innovation (MERI). While a review of the literature discovered narrative accounts of MERI unit development, we found no systematic examinations of the dimensions of and structures that facilitate the success of these units. We conducted qualitative interviews with the directors of 12 MERI units across Canada. Data were analyzed using qualitative description (Sandelowski in Res Nurs Health 23:334-340, 2000). Final analysis drew on Bourdieu's (Outline of a theory of practice. Cambridge University Press, Cambridge, 1977; Media, culture and society: a critical reader. Sage, London, 1986; Language and symbolic power. Harvard University Press, Cambridge, 1991) concepts of field, habitus, and capital, and more recent research investigating the field of MERI (Albert in Acad Med 79:948-954, 2004; Albert et al. in Adv Health Sci Educ 12:103-115, 2007). When asked about the metrics by which they define their success, directors cited: teaching, faculty mentoring, building collaborations, delivering conference presentations, winning grant funding, and disseminating publications. Analyzed using Bourdieu's concepts, these metrics are discussed as forms of capital that have been legitimized in the MERI field. All directors, with the exception of one, described success as being comprised of elements (capital) at both ends of the service-research spectrum (i.e., Albert's PP-PU structure). Our analysis highlights the forms of habitus (i.e., behaviors, attitudes, demeanors) directors use to negotiate, strategize and position the unit within their local context. These findings may assist institutions in developing a new-or reorganizing an existing-MERI unit. We posit that a better understanding of these complex social structures can help units become savvy participants in the MERI field. With such insight, units can improve their academic output and

  16. Genome-Wide Mapping of Transcriptional Regulation and Metabolism Describes Information-Processing Units in Escherichia coli

    Daniela Ledezma-Tejeida

    2017-08-01

    Full Text Available In the face of changes in their environment, bacteria adjust gene expression levels and produce appropriate responses. The individual layers of this process have been widely studied: the transcriptional regulatory network describes the regulatory interactions that produce changes in the metabolic network, both of which are coordinated by the signaling network, but the interplay between them has never been described in a systematic fashion. Here, we formalize the process of detection and processing of environmental information mediated by individual transcription factors (TFs, utilizing a concept termed genetic sensory response units (GENSOR units, which are composed of four components: (1 a signal, (2 signal transduction, (3 genetic switch, and (4 a response. We used experimentally validated data sets from two databases to assemble a GENSOR unit for each of the 189 local TFs of Escherichia coli K-12 contained in the RegulonDB database. Further analysis suggested that feedback is a common occurrence in signal processing, and there is a gradient of functional complexity in the response mediated by each TF, as opposed to a one regulator/one pathway rule. Finally, we provide examples of other GENSOR unit applications, such as hypothesis generation, detailed description of cellular decision making, and elucidation of indirect regulatory mechanisms.

  17. /sup 15/N analysis in nutritional and metabolic research of infancy

    Heine, W; Richter, I; Plath, C; Wutzke, K; Drescher, U [Rostock Univ. (German Democratic Republic). Bereich Medizin

    1982-01-01

    Investigation of protein metabolism in nutritional pediatric research by means of /sup 15/N tracer techniques has been relatively seldom used up to now. /sup 15/N-labelled compounds for these purposes are not injurious to health. The technique is based on oral or intravenous application of the tracer substances and on /sup 15/N analysis of the urine fractions. The subsequent calculation of protein synthesis and breakdown rate, turnover, and the reutilisation of amino acids from protein breakdown as well as the size of the metabolic pool offers detailed information of protein metabolism. Determination of these parameters were performed in infants on breast milk, formula feeding and on chemically defined diet. As an example of utilisation of D-amino acids for protein synthesis the /sup 15/N-D-phenylalanine retention of parenteral nutrition was found to be 33% of the applied doses at an average. An oral /sup 15/N-glycine loading test proved to be of value for the prediction of the therapeutic effect of human growth hormone. /sup 15/N tracer technique was also tested in utilizing /sup 15/N-urea for bacterial protein synthesis of the intestinal flora and by incorporation of /sup 15/N from /sup 15/N-glycine and /sup 15/N-lysine into the jejunal mucosa for measuring the enterocyte regeneration.

  18. A mini review of dolphin carbohydrate metabolism and suggestions for future research using exhaled air

    Sam eRidgway

    2013-12-01

    Full Text Available In the 1960s, I explored some aspects of carbohydrate metabolism in healthy bottlenose dolphins (Tursiops truncatus. Their physiological picture resembled what had been described for hyperthyroid diabetics. Dolphins have elevated thyroid hormone turnover, and fasting dolphins maintain a relatively high level of plasma glucose. After dolphins ingest glucose, plasma levels remain high for many hours. Interestingly, plasma glucose must exceed 300 mg/dL (about twice as high as the human threshold before glucose appears in urine. Due to their diabetes-like states, trainability, and unique natural respiratory anatomy and physiology, dolphins may offer useful clues to metabolites in the breath that may be used to non-invasively monitor diabetes in humans. Dolphins take very rapid and deep breaths that are four or five times as deep as humans and other terrestrial mammals, making them ideal for physiological assessment using non-invasive exhaled air. Avenues for successfully identifying breath-based markers for metabolic disease and physiology in dolphins can be done with both modern technology and the evolutionarily advantageous canine nose. This review summarizes aspects of dolphin metabolism previously learned and offers new directions for diabetes research that may benefit both dolphin and human health.

  19. The research of high voltage switchgear detecting unit

    Ji, Tong; Xie, Wei; Wang, Xiaoqing; Zhang, Jinbo

    2017-07-01

    In order to understand the status of the high voltage switch in the whole life circle, you must monitor the mechanical and electrical parameters that affect device health. So this paper gives a new high voltage switchgear detecting unit based on ARM technology. It can measure closing-opening mechanical wave, storage motor current wave and contactor temperature to judge the device’s health status. When something goes wrong, it can be on alert and give some advice. The practice showed that it can meet the requirements of circuit breaker mechanical properties temperature online detection.

  20. The United States Advanced Reactor Technologies Research and Development Program

    O’Connor, Thomas J.

    2014-01-01

    The following aspects are addressed: • Nuclear energy mission; • Reactor research development and deployment (RD&D) programs: - Light Water Reactor Sustainability Program; - Small Modular Reactor Licensing Technical Support; - Advanced Reactor Technologies (ART)

  1. Market research of window units and doors industry in Russia

    Grishankova, Elena

    2010-01-01

    The purpose of this research is to analyze macro-environmental and competitive forces in the Russian market and to determine possible entry modes for a new company. Some practical information on legal issues and regulatory organizations is also included in the paper in order to create a comprehensive overview of any potentially influential factors. The conceptual framework is based on the macro-environmental market research approach, Michael Porter’s five forces framework and internationa...

  2. United States Crystalline Repository Project - key research areas

    Patera, E.S.

    1986-01-01

    The Crystalline Repository Project is responsible for siting the second high-level nuclear waste repository in crystalline rock for the US Department of Energy. A methodology is being developed to define data and information needs and a way to evaluate that information. The areas of research the Crystalline Repository Project is involved in include fluid flow in a fractured network, coupled thermal, chemical and flow processes and cooperation in other nations and OECD research programs

  3. Uniting Resilience Research and Practice With an Inequalities Approach

    Angie Hart

    2016-12-01

    Full Text Available The concept of resilience has evolved, from an individual-level characteristic to a wider ecological notion that takes into account broader person–environment interactions, generating an increased interest in health and well-being research, practice and policy. At the same time, the research and policy-based attempts to build resilience are increasingly under attack for responsibilizing individuals and maintaining, rather than challenging, the inequitable structure of society. When adversities faced by children and young people result from embedded inequality and social disadvantage, resilience-based knowledge has the potential to influence the wider adversity context. Therefore, it is vital that conceptualizations of resilience encompass this potential for marginalized people to challenge and transform aspects of their adversity, without holding them responsible for the barriers they face. This article outlines and provides examples from an approach that we are taking in our research and practice, which we have called Boingboing resilience. We argue that it is possible to bring resilience research and practice together with a social justice approach, giving equal and simultaneous attention to individuals and to the wider system. To achieve this goal, we suggest future research should have a co-produced and inclusive research design that overcomes the dilemma of agency and responsibility, contains a socially transformative element, and has the potential to empower children, young people, and families.

  4. Precision-cut intestinal slices: alternative model for drug transport, metabolism, and toxicology research.

    Li, Ming; de Graaf, Inge A M; Groothuis, Geny M M

    2016-01-01

    The absorption, distribution, metabolism, excretion and toxicity (ADME-tox) processes of drugs are of importance and require preclinical investigation intestine in addition to the liver. Various models have been developed for prediction of ADME-tox in the intestine. In this review, precision-cut intestinal slices (PCIS) are discussed and highlighted as model for ADME-tox studies. This review provides an overview of the applications and an update of the most recent research on PCIS as an ex vivo model to study the transport, metabolism and toxicology of drugs and other xenobiotics. The unique features of PCIS and the differences with other models as well as the translational aspects are also discussed. PCIS are a simple, fast, and reliable ex vivo model for drug ADME-tox research. Therefore, PCIS are expected to become an indispensable link in the in vitro-ex vivo-in vivo extrapolation, and a bridge in translation of animal data to the human situation. In the future, this model may be helpful to study the effects of interorgan interactions, intestinal bacteria, excipients and drug formulations on the ADME-tox properties of drugs. The optimization of culture medium and the development of a (cryo)preservation technique require more research.

  5. Toxic-metabolic Risk Factors in Pediatric Pancreatitis: Recommendations for Diagnosis, Management, and Future Research.

    Husain, Sohail Z; Morinville, Veronique; Pohl, John; Abu-El-Haija, Maisam; Bellin, Melena D; Freedman, Steve; Hegyi, Peter; Heyman, Melvin B; Himes, Ryan; Ooi, Chee Y; Schwarzenberg, Sarah J; Usatin, Danielle; Uc, Aliye

    2016-04-01

    Pancreatitis in children can result from metabolic and toxic risk factors, but the evidence linking these factors is sparse. We review the evidence for association or causality of these risk factors in pancreatitis, discuss management strategies, and their rationale. We conducted a review of the pediatric pancreatitis literature with respect to the following risk factors: hyperlipidemia, hypercalcemia, chronic renal failure, smoking exposure, alcohol, and medications. Areas of additional research were identified. Hypertriglyceridemia of 1000 mg/dL or greater poses an absolute risk for pancreatitis; persistent elevations of calcium are predisposing. Further research is necessary to determine whether end-stage renal disease leads to increased pancreatitis in children similar to adults. It is unknown whether cigarette smoking exposure, which clearly increases risk in adults, also increases risk in children. The role of alcohol in pediatric pancreatitis, whether direct or modifying, needs to be elucidated. The evidence supporting most cases of medication-induced pancreatitis is poor. Drug structure, improper handling of drug by host, and bystander status may be implicated. Other pancreatitis risk factors must be sought in all cases. The quality of evidence supporting causative role of various toxic and metabolic factors in pediatric pancreatitis is variable. Careful phenotyping is essential, including search for other etiologic risk factors. Directed therapy includes correction/removal of any agent identified, and general supportive measures. Further research is necessary to improve our understanding of these pancreatitis risk factors in children.

  6. Toxic-Metabolic Risk Factors in Pediatric Pancreatitis: Recommendations for Diagnosis, Management and Future Research

    Husain, Sohail Z.; Morinville, Veronique; Pohl, John; Abu-El-Haija, Maisam; Bellin, Melena D.; Freedman, Steve; Hegyi, Peter; Heyman, Melvin B; Himes, Ryan; Ooi, Chee Y.; Schwarzenberg, Sarah Jane; Usatin, Danielle; Uc, Aliye

    2016-01-01

    Objectives Pancreatitis in children can result from metabolic and toxic risk factors, but the evidence linking these factors is sparse. We review the evidence for association or causality of these risk factors in pancreatitis, discuss management strategies and their rationale. Methods We conducted a review of the pediatric pancreatitis literature with respect to the following risk factors: (a) hyperlipidemia, (b) hypercalcemia, (c) chronic renal failure, (d) smoking exposure, (e) alcohol, and (f) medications. Areas of additional research were identified. Results Hypertriglyceridemia of 1000 mg/dl or greater poses an absolute risk for pancreatitis; persistent elevations of calcium are predisposing. Further research is necessary to determine whether end stage renal disease leads to increased pancreatitis in children similar to adults. It is unknown whether cigarette smoking exposure, which clearly increases risk in adults, also increases risk in children. The role of alcohol in pediatric pancreatitis, whether direct or modifying, needs to be elucidated. The evidence supporting most cases of medication-induced pancreatitis is poor. Drug structure, improper handling of drug by host, and by-stander status may be implicated. Other pancreatitis risk factors must be sought in all cases. Conclusions The quality of evidence supporting causative role of various toxic and metabolic factors in pediatric pancreatitis is variable. Careful phenotyping is essential, including search for other etiologic risk factors. Directed therapy includes correction/ removal of any agent identified, and general supportive measures. Further research is necessary to improve our understanding of these pancreatitis risk factors in children. PMID:26594832

  7. United Kingdom health research analyses and the benefits of shared data.

    Carter, James G; Sherbon, Beverley J; Viney, Ian S

    2016-06-24

    To allow research organisations to co-ordinate activity to the benefit of national and international funding strategies requires assessment of the funding landscape; this, in turn, relies on a consistent approach for comparing expenditure on research. Here, we discuss the impact and benefits of the United Kingdom's Health Research Classification System (HRCS) in national landscaping analysis of health research and the pros and cons of performing large-scale funding analyses. The first United Kingdom health research analysis (2004/2005) brought together the 11 largest public and charity funders of health research to develop the HRCS and use this categorisation to examine United Kingdom health research. The analysis was revisited in 2009/2010 and again in 2014. The most recent quinquennial analysis in 2014 compiled data from 64 United Kingdom research organisations, accounting for 91% of all public/charitable health research funding in the United Kingdom. The three analyses summarise the United Kingdom's health research expenditure in 2004/2005, 2009/2010 and 2014, and can be used to identify changes in research activity and disease focus over this 10 year period. The 2004/2005 analysis provided a baseline for future reporting and evidence for a United Kingdom Government review that recommended the co-ordination of United Kingdom health research should be strengthened to accelerate the translation of basic research into clinical and economic benefits. Through the second and third analyses, we observed strategic prioritisation of certain health research activities and disease areas, with a strong trend toward increased funding for more translational research, and increases in specific areas such as research on prevention. The use of HRCS in the United Kingdom to analyse the research landscape has provided benefit both to individual participatory funders and in coordinating initiatives at a national level. A modest amount of data for each project is sufficient for a

  8. Mapping Investments and Published Outputs in Norovirus Research: A Systematic Analysis of Research Funded in the United States and United Kingdom During 1997-2013.

    Head, Michael G; Fitchett, Joseph R; Lichtman, Amos B; Soyode, Damilola T; Harris, Jennifer N; Atun, Rifat

    2016-02-01

    Norovirus accounts for a considerable portion of the global disease burden. Mapping national or international investments relating to norovirus research is limited. We analyzed the focus and type of norovirus research funding awarded to institutions in the United States and United Kingdom during 1997-2013. Data were obtained from key public and philanthropic funders across both countries, and norovirus-related research was identified from study titles and abstracts. Included studies were further categorized by the type of scientific investigation, and awards related to vaccine, diagnostic, and therapeutic research were identified. Norovirus publication trends are also described using data from Scopus. In total, US and United Kingdom funding investment for norovirus research was £97.6 million across 349 awards; 326 awards (amount, £84.9 million) were received by US institutions, and 23 awards (£12.6 million) were received by United Kingdom institutions. Combined, £81.2 million of the funding (83.2%) was for preclinical research, and £16.4 million (16.8%) was for translational science. Investments increased from £1.7 million in 1997 to £11.8 million in 2013. Publication trends showed a consistent temporal increase from 48 in 1997 to 182 in 2013. Despite increases over time, trends in US and United Kingdom funding for norovirus research clearly demonstrate insufficient translational research and limited investment in diagnostics, therapeutics, or vaccine research. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

  9. Protein turnover and metabolism in the elderly intensive care unit patient

    Phillips, Stuart M.; Dickerson, Roland N.; Moore, Frederick A.; Paddon-Jones, Douglas; Weijs, Peter J. M.

    2017-01-01

    Many intensive care unit (ICU) patients do not achieve target protein intakes particularly in the early days following admittance. This period of iatrogenic protein undernutrition contributes to a rapid loss of lean, in particular muscle, mass in the ICU. The loss of muscle in older (aged >60 years)

  10. Uncited Research Articles in Popular United States General Radiology Journals.

    Rosenkrantz, Andrew B; Chung, Ryan; Duszak, Richard

    2018-05-03

    This study aimed to characterize articles in popular general radiology journals that go uncited for a decade after publication. Using the Web of Science database, we identified annual citation counts for 13,459 articles published in Radiology, American Journal of Roentgenology, and Academic Radiology between 1997 and 2006. From this article cohort, we then identified all original research articles that accrued zero citations within a decade of publication. A concurrent equal-sized cohort of most cited articles was created. Numerous characteristics of the uncited and most cited articles were identified and compared. Only 47 uncited articles went uncited for a decade after publication. When compared to the 47 most cited articles over that same window, the uncited articles were significantly (P articles, uncited articles also had significantly (P articles published in popular general radiology journals, only a very small number of original research investigations remained uncited a decade after publication. Given that citations reflect the impact of radiology research, this observation suggests that journals are appropriately selecting meaningful work. Investigators seeking to avoid futile publication might consider their research initiatives in light of these characteristics. Copyright © 2018 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.

  11. Toxic Hazards Research Unit Annual Technical Report: 1985

    1985-09-01

    varnish makers’ and painters’ naphtha, Toxicol. Appl. Pharmacol., 32:263-281. Carpenter, C. P.. E. R. Kinkead, D. L. Geary, L. J. Sullivan, Jr., and J...and Pharmacology of Inorganic and Fluorine Contairnin Compounds, AMRL-TR-67-224, Aerospace Medical Research Laboiatory, Wright-Patterson Air Force Base

  12. [Research advance in metabolism of effective ingredients from traditional Chinese medicines by probiotics].

    Dai, Cheng-En; Li, Hai-Long; He, Xiao-Ping; Zheng, Fen-Fen; Zhu, Hua-Liu; Liu, Liang-Feng; Du, Wei

    2018-01-01

    The pharmacological activity of active ingredients from Chinese medicine depends greatly on the microecological environment of probiotics in the human body. After effective ingredients from traditional Chinese medicines are metabolized or biotransformed by probiotics, their metabolites can increase pharmacological activity, and can be absorbed more easily to improve the bioavailability. Therefore, the combination of Chinese medicines with probiotics is the innovation point in R&D of functional food and Chinese medicines, and also a new thinking for the modernization of Chinese medicine.This review summarizes and analyses the research progress on metabolism effects of gut microbiota on Chinese medicines components, the regulating effect of effective ingredients from Chinese medicine on intestinal probiotics, the application status of probiotics in traditional Chinese medicines, and the main problems and prospects in the research and development of Chinese medicines products with probiotic, aiming to provide theoretical guidance and practical value for the fermentation engineering of Chinese herbal medicine. Copyright© by the Chinese Pharmaceutical Association.

  13. Towards human exploration of space: The THESEUS review series on nutrition and metabolism research priorities.

    Bergouignan, Audrey; Stein, T Peter; Habold, Caroline; Coxam, Veronique; O' Gorman, Donal; Blanc, Stéphane

    2016-01-01

    Nutrition has multiple roles during space flight from providing sufficient nutrients to meet the metabolic needs of the body and to maintain good health, to the beneficial psychosocial aspects related to the meals. Nutrition is central to the functioning of the body; poor nutrition compromises all the physiological systems. Nutrition is therefore likely to have a key role in counteracting the negative effects of space flight (e.g., radiation, immune deficits, oxidative stress, and bone and muscle loss). As missions increase in duration, any dietary/nutritional deficiencies will become progressively more detrimental. Moreover, it has been recognized that the human diet contains, in addition to essential macronutrients, a complex array of naturally occurring bioactive micronutrients that may confer significant long-term health benefits. It is therefore critical that astronauts be adequately nourished during missions. Problems of nutritional origin are often treatable by simply providing the appropriate nutrients and adequate recommendations. This review highlights six key issues that have been identified as space research priorities in nutrition field: in-flight energy balance; altered feeding behavior; development of metabolic stress; micronutrient deficiency; alteration of gut microflora; and altered fluid and electrolytes balance. For each of these topics, relevance for space exploration, knowledge gaps and proposed investigations are described. Finally, the nutritional questions related to bioastronautics research are very relevant to multiple ground-based-related health issues. The potential spin-offs are both interesting scientifically and potentially of great clinical importance.

  14. Toxic Hazards Research Unit Annual Technical Report: 1984

    1984-09-01

    exposed to TOCP exhibited the classic lesions of delayed neuropathy (Smith and Lillie, 1931; Barnes and Denz, 1953; (avanagh, 1954; and Fenton , 1955...Safety of *.i Chemicals in Food, Drugs, and Cosmetics , The staff of the Divi- sion of Pharmacology of the Federal Food and Drug Administration, Austin...Annual Technical Report: 1967, AMRL-TR-67-137 (AD 834723), Aerospace Medical Research Laboratory, Wright-Patterson Air Force Base, Ohio. Fenton , J. C

  15. Wind Energy in the United States: Market and Research Update

    Goldman, P.R.; Thresher, R.W.; Hock, S.M.

    1999-01-01

    U.S. market activity has increased over the last two years. In 1998, new capacity totaled about 150 MW and projected 1999 capacity additions are over 600 MW. As the electricity market continues to evolve under restructuring, the U.S. Department of Energy (U.S. DOE) Wind Energy Program has positioned itself to work with industry to meet current challenges and opportunities, and prepare for the market of tomorrow. Some opportunities include green power markets and distributed applications, although a primary challenge involves the fact that avoided cost payments to renewable generators are not high enough to economically support projects. A recently incorporated power exchange in California, APX, Inc., has demonstrated that green power does attract a premium over prices on the conventional power exchange. The key elements of the U.S. DOE Wind Program are (1) Applied Research, which is critical for achieving advanced turbine designs capable of competing in a restructured market that emphasizes low cost generation; (2) Turbine Research, which supports the U.S. industry in developing competitive, high performance, reliable wind turbine technology for global energy markets; and (3) Cooperative Research and Testing, under which standards development and certification testing are the key activities for the current year

  16. An Overview of Research Infrastructure for Medieval Studies in the United States: Associations, Institutes, and Universities

    Zan Kocher

    2011-11-01

    Full Text Available This overview of research infrastructure in the United States brieflymentions some institutes, universities, associations, conferences,sources of funding, types of courses, research databases, academicjournals and book publishers. It intends to make American medievalistresources better accessible to colleagues from other countries, and toencourage those who wish to study in the United States and those whoare using the Internet to seek printed or digital materials for theirteaching or research.

  17. Enabling International Safeguards Research and Development in the United States

    Dwight, John E.; Schanfein, Mark J.; Bjornard, Trond A.

    2009-01-01

    Idaho National Laboratory (INL) is the lead laboratory in nuclear energy research and development within the U.S. Department of Energy national laboratory complex. INL is tasked with the advancement of nuclear energy research and development, and leadership in the renaissance of nuclear power globally. INL scientists have been central to the assessment of needs and the integration of technical programs aimed at the world-wide growth of nuclear power. One of the grand challenges of the nuclear energy resurgence is nuclear nonproliferation. Nonproliferation technology development is key to meeting this challenge. The needed advances in nonproliferation technologies are being made more difficult by the growing gap between increasing demands for nuclear materials to support technology development, and reduced availability of these materials. The gap is caused by the reduction, consolidation and more stringent lockdown of nuclear materials, made necessary by heightened and evolving security concerns, in the face of increased demand for materials to support technology development. Ironically, the increased demand for materials for technology development is made necessary by these same security concerns. The situation will continue to worsen if safeguards and security budgets remain limited for the International Atomic Energy Agency (IAEA) and many member states, while growth in global nuclear energy becomes a reality. Effective U.S. leadership in the closing of this gap is vital to homeland security and global stability. INL has taken positive steps, described in this paper, to close this gap by reestablishing a viable base for the development, testing and demonstration of safeguards and security technologies. Key attributes of this technology development base are (1) the availability of a wide variety of special nuclear materials in forms that allow for enhanced accessibility; (2) ease of access by U.S. government, national laboratory, industry and academic institution

  18. An overview of enabling technology research in the United States

    Baker, Charles C.

    2002-01-01

    The mission of the US Fusion Energy Sciences Program is to advance plasma science, fusion science, and fusion technology--the knowledge base needed for an economically and environmentally attractive fusion energy source. In support of this overall mission, the Enabling Technology Program in the US incorporates both near and long term R and D, contributes to material and engineering sciences as well as technology development, contributes to spin-off applications, and performs global systems assessments and focused design studies. This work supports both magnetic and inertial fusion energy (IFE) concepts. The Enabling Technology research mission is to contribute to the national science and technology base by developing the enabling technology for existing and next-step experimental devices, by exploring and understanding key materials and technology feasibility issues for attractive fusion power sources, by conducting advanced design studies that integrate the wealth of our understanding to guide R and D priorities and by developing design solutions for next-step and future devices. The Enabling Technology Program Plan is organized around five elements: plasma technologies, fusion (chamber) technologies, materials sciences, advanced design, and IFE chamber and target technologies. The principal technical features and research objectives are described for each element

  19. An example of a United States Nuclear Research Center

    Bhattacharyya, S. K.

    1999-01-01

    Under the likely scenario in which public support for nuclear energy remains low and fossil fuels continue to be abundant and cheap, government supported nuclear research centers must adapt their missions to ensure that they tackle problems of current significance. It will be critical to be multidisciplinary, to generate economic value, and to apply nuclear competencies to current problems. Addressing problems in nuclear safety, D and D, nuclear waste management, nonproliferation, isotope production are a few examples of current needs in the nuclear arena. Argonne's original mission, to develop nuclear reactor technology, was a critical need for the U.S. in 1946. It would be wise to recognize that this mission was a special instance of a more general one--to apply unique human and physical capital to long term, high risk technology development in response to society's needs. International collaboration will enhance the collective chances for success as the world moves into the 21st century

  20. Public Spending on Health Service and Policy Research in Canada, the United Kingdom, and the United States: A Modest Proposal

    Vidhi Thakkar

    2017-11-01

    Full Text Available Health services and policy research (HSPR represent a multidisciplinary field which integrates knowledge from health economics, health policy, health technology assessment, epidemiology, political science among other fields, to evaluate decisions in health service delivery. Health service decisions are informed by evidence at the clinical, organizational, and policy level, levels with distinct, managerial drivers. HSPR has an evolving discourse spanning knowledge translation, linkage and exchange between research and decision-maker partners and more recently, implementation science and learning health systems. Local context is important for HSPR and is important in advancing health reform practice. The amounts and configuration of national investment in this field remain important considerations which reflect priority investment areas. The priorities set within this field or research may have greater or lesser effects and promise with respect to modernizing health services in pursuit of better value and better population outcomes. Within Canada an asset map for HSPR was published by the national HSPR research institute. Having estimated publiclyfunded research spending in Canada, we sought identify best available comparable estimates from the United States and the United Kingdom. Investments from industry and charitable organizations were not included in these numbers. This commentary explores spending by the United States, Canada, and the United Kingdom on HSPR as a fraction of total public spending on health and the importance of these respective investments in advancing health service performance. Proposals are offered on the merits of common nomenclature and accounting for areas of investigation in pursuit of some comparable way of assessing priority HSPR investments and suggestions for earmarking such investments to total investment in health services spending.

  1. United Kingdom. Report 1 [Marine Radioecology. Current Research and Future Scope

    Templeton, W.L.

    1967-01-01

    Present research programme (long-term): There are five separate research projects in this Group, viz: A. Low-level irradiation studies on marine and fresh-water fish eggs. B. Accumulation and. metabolism of radionuclides by marine organisms. C. Physico-chemical states of radionuclides in sea water, D. Dispersion and transport of radionuclides in the coastal waters of Windscale. E. Mechanisms of the toxicity of zinc to fish. Details of each project are outlined

  2. International stem cell collaboration: how disparate policies between the United States and the United Kingdom impact research.

    Luo, Jingyuan; Flynn, Jesse M; Solnick, Rachel E; Ecklund, Elaine Howard; Matthews, Kirstin R W

    2011-03-08

    As the scientific community globalizes, it is increasingly important to understand the effects of international collaboration on the quality and quantity of research produced. While it is generally assumed that international collaboration enhances the quality of research, this phenomenon is not well examined. Stem cell research is unique in that it is both politically charged and a research area that often generates international collaborations, making it an ideal case through which to examine international collaborations. Furthermore, with promising medical applications, the research area is dynamic and responsive to a globalizing science environment. Thus, studying international collaborations in stem cell research elucidates the role of existing international networks in promoting quality research, as well as the effects that disparate national policies might have on research. This study examined the impact of collaboration on publication significance in the United States and the United Kingdom, world leaders in stem cell research with disparate policies. We reviewed publications by US and UK authors from 2008, along with their citation rates and the political factors that may have contributed to the number of international collaborations. The data demonstrated that international collaborations significantly increased an article's impact for UK and US investigators. While this applied to UK authors whether they were corresponding or secondary, this effect was most significant for US authors who were corresponding authors. While the UK exhibited a higher proportion of international publications than the US, this difference was consistent with overall trends in international scientific collaboration. The findings suggested that national stem cell policy differences and regulatory mechanisms driving international stem cell research in the US and UK did not affect the frequency of international collaborations, or even the countries with which the US and UK most

  3. Sanford Underground Research Facility - The United State's Deep Underground Research Facility

    Vardiman, D.

    2012-12-01

    The 2.5 km deep Sanford Underground Research Facility (SURF) is managed by the South Dakota Science and Technology Authority (SDSTA) at the former Homestake Mine site in Lead, South Dakota. The US Department of Energy currently supports the development of the facility using a phased approach for underground deployment of experiments as they obtain an advanced design stage. The geology of the Sanford Laboratory site has been studied during the 125 years of operations at the Homestake Mine and more recently as part of the preliminary geotechnical site investigations for the NSF's Deep Underground Science and Engineering Laboratory project. The overall geology at DUSEL is a well-defined stratigraphic sequence of schist and phyllites. The three major Proterozoic units encountered in the underground consist of interbedded schist, metasediments, and amphibolite schist which are crosscut by Tertiary rhyolite dikes. Preliminary geotechnical site investigations included drift mapping, borehole drilling, borehole televiewing, in-situ stress analysis, laboratory analysis of core, mapping and laser scanning of new excavations, modeling and analysis of all geotechnical information. The investigation was focused upon the determination if the proposed site rock mass could support the world's largest (66 meter diameter) deep underground excavation. While the DUSEL project has subsequently been significantly modified, these data are still available to provide a baseline of the ground conditions which may be judiciously extrapolated throughout the entire Proterozoic rock assemblage for future excavations. Recommendations for facility instrumentation and monitoring were included in the preliminary design of the DUSEL project design and include; single and multiple point extensometers, tape extensometers and convergence measurements (pins), load cells and pressure cells, smart cables, inclinometers/Tiltmeters, Piezometers, thermistors, seismographs and accelerometers, scanners (laser

  4. Developing a clinical trial unit to advance research in an academic institution.

    Croghan, Ivana T; Viker, Steven D; Limper, Andrew H; Evans, Tamara K; Cornell, Alissa R; Ebbert, Jon O; Gertz, Morie A

    2015-11-01

    Research, clinical care, and education are the three cornerstones of academic health centers in the United States. The research climate has always been riddled with ebbs and flows, depending on funding availability. During a time of reduced funding, the number and scope of research studies have been reduced, and in some instances, a field of study has been eliminated. Recent reductions in the research funding landscape have led institutions to explore new ways to continue supporting research. Mayo Clinic in Rochester, MN has developed a clinical trial unit within the Department of Medicine, which provides shared resources for many researchers and serves as a solution for training and mentoring new investigators and study teams. By building on existing infrastructure and providing supplemental resources to existing research, the Department of Medicine clinical trial unit has evolved into an effective mechanism for conducting research. This article discusses the creation of a central unit to provide research support in clinical trials and presents the advantages, disadvantages, and required building blocks for such a unit. Copyright © 2015 Mayo Clinic. Published by Elsevier Inc. All rights reserved.

  5. The care unit in nursing home research: evidence in support of a definition.

    Estabrooks, Carole A; Morgan, Debra G; Squires, Janet E; Boström, Anne-Marie; Slaughter, Susan E; Cummings, Greta G; Norton, Peter G

    2011-04-14

    Defining what constitutes a resident care unit in nursing home research is both a conceptual and practical challenge. The aim of this paper is to provide evidence in support of a definition of care unit in nursing homes by demonstrating: (1) its feasibility for use in data collection, (2) the acceptability of aggregating individual responses to the unit level, and (3) the benefit of including unit level data in explanatory models. An observational study design was used. Research (project) managers, healthcare aides, care managers, nursing home administrators and directors of care from thirty-six nursing homes in the Canadian prairie provinces of Alberta, Saskatchewan and Manitoba provided data for the study. A definition of care unit was developed and applied in data collection and analyses. A debriefing session was held with research managers to investigate their experiences with using the care unit definition. In addition, survey responses from 1258 healthcare aides in 25 of the 36 nursing homes in the study, that had more than one care unit, were analyzed using a multi-level modeling approach. Trained field workers administered the Alberta Context Tool (ACT), a 58-item self-report survey reflecting 10 organizational context concepts, to healthcare aides using computer assisted personal interviews. To assess the appropriateness of obtaining unit level scores, we assessed aggregation statistics (ICC(1), ICC(2), η², and ω²), and to assess the value of using the definition of unit in explanatory models, we performed multi-level modeling. In 10 of the 36 nursing homes, the care unit definition developed was used to align the survey data (for analytic purposes) to specific care units as designated by our definition, from that reported by the facility administrator. The aggregation statistics supported aggregating the healthcare aide responses on the ACT to the realigned unit level. Findings from the multi-level modeling further supported unit level aggregation. A

  6. Report by the AERES on the unit: Research unit on the environment under the supervision of establishments and bodies: IRSN

    2010-10-01

    This report is a kind of audit report on a research laboratory. The authors discuss an assessment of the whole unit activities in terms of strengths and opportunities, aspects to be improved and risks, productions and publications, scientific quality, influence and attractiveness (awards, recruitment capacity, capacity to obtain financing and to tender, participation to international programs), strategy and governance, and project. These same aspects are then discussed and commented for each research axis: study of the seismic hazard, study of risk management related to waste storage in deep geological layer, radionuclide transfer in the biosphere, study of the effects on ecosystems of a chronic exposure to radioactive materials

  7. Supplemented Creatine Induces Changes in Human Metabolism of Thiocompounds and One- and Two-Carbon Units

    Navrátil, Tomáš; Kohlíková, E.; Petr, M.; Pelclová, D.; Heyrovský, Michael; Přistoupilová, K.

    2010-01-01

    Roč. 59, č. 3 (2010), s. 431-442 ISSN 0862-8408 R&D Projects: GA AV ČR IAA400400806 Institutional research plan: CEZ:AV0Z40400503 Keywords : creatine * creatinine * folates * homocysteine Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 1.646, year: 2010

  8. Proteomic Contributions to Medicinal Plant Research: From Plant Metabolism to Pharmacological Action

    Akiko Hashiguchi

    2017-12-01

    Full Text Available Herbal medicine is a clinical practice of utilizing medicinal plant derivatives for therapeutic purposes. It has an enduring history worldwide and plays a significant role in the fight against various diseases. Herbal drug combinations often exhibit synergistic therapeutic action compared with single-constituent dosage, and can also enhance the cytotoxicity induced by chemotherapeutic drugs. To explore the mechanism underlying the pharmacological action of herbs, proteomic approaches have been applied to the physiology of medicinal plants and its effects on animals. This review article focuses on the existing proteomics-based medicinal plant research and discusses the following topics: (i plant metabolic pathways that synthesize an array of bioactive compounds; (ii pharmacological action of plants tested using in vivo and in vitro studies; and (iii the application of proteomic approaches to indigenous plants with scarce sequence information. The accumulation of proteomic information in a biological or medicinal context may help in formulating the effective use of medicinal plants.

  9. Coordinated Research Projects of the IAEA Atomic and Molecular Data Unit

    Braams, B. J.; Chung, H.-K.

    2011-05-01

    The IAEA Atomic and Molecular Data Unit is dedicated to the provision of databases for atomic, molecular and plasma-material interaction (AM/PMI) data that are relevant for nuclear fusion research. IAEA Coordinated Research Projects (CRPs) are the principal mechanism by which the Unit encourages data evaluation and the production of new data. Ongoing and planned CRPs on AM/PMI data are briefly described here.

  10. Coordinated Research Projects of the IAEA Atomic and Molecular Data Unit

    Braams, B. J.; Chung, H.-K.

    2011-01-01

    The IAEA Atomic and Molecular Data Unit is dedicated to the provision of databases for atomic, molecular and plasma-material interaction (AM/PMI) data that are relevant for nuclear fusion research. IAEA Coordinated Research Projects (CRPs) are the principal mechanism by which the Unit encourages data evaluation and the production of new data. Ongoing and planned CRPs on AM/PMI data are briefly described here.

  11. United States Air Force Graduate Student Research Program. Program Technical rept. Volume 3

    1988-12-01

    patients with coronary artery disease routinely have continuous LV pressures recorded, applying the nuclear stethoscope concurrently will allow...research project. 73-3 I. INTRODUCTION: Bone defects can result from removal of bone from donor sites, diseased bone, excision of tumors, pathologic...large body of data which has clearly documented the existence of a " respiratory burst" of metabolic activity associated with phagocytosis El]. The

  12. The nursing professorial unit: translating acute and critical care nursing research

    Martin Christensen

    2017-11-01

    Full Text Available Background and context: Implementation of current research in practice is challenging for ward-based nursing staff. However, university-based nursing academics are seen as the research experts and are perhaps well placed to support clinical nursing research. The problem lies with the divide between practice and academia; universities often use the clinical environment as the place to conduct research but this is often not translated effectively into practice. The development of a nursing professorial unit for acute and critical care was undertaken to meet this challenge. The unit’s key aim is to develop, mentor and support a nursing research culture that is wholly situated within and driven by the requirements of the clinical environment. Aim: The aim of this article is to offer some insights as to how staff set about engaging with and developing the nursing professorial unit to support nursing research in our local hospital. Conclusions: The article highlights how an effective and coordinated approach to supporting clinical nursing research is possible. The nursing professorial unit has been successful in bridging the divide between academia and practice by using a non-university approach to supporting nursing research. Instead we have adopted the philosophy that practice is the sole driver for research and as academics our role is to support that position. Implications for practice: The adoption of the nursing professorial unit model for supporting clinical nursing research is beneficial in closing the divide between clinical practice and the university The continual presence of the academics in the clinical environment has had a positive impact on research development and implementation in practice The nursing professorial unit has become an integral part of the nursing culture in the hospital environment

  13. An Agenda for Growth and Metabolism Research in Farm Animals: Healthy Food for a Healthy Nation

    Vega, R. S. A.; Manalo, D. D.; Garcia, J. N. M.

    2018-02-01

    The aim of this paper is to present a paradigm shift from meat demand to health driven understanding of the effects of livestock production and meat consumption in human. Included are comments on animal nutrition research with the purpose of getting more relevant health information. The growth and metabolism research covers the principles from feed intake regulation, nutrient digestion, absorption and growth. Meat preservation provides enough food for the urban population, and its major ingredient includes the combination of salt, sugar and fats, suspected to cause food addiction in man. The reported effect of processed red meat causing systemic inflammation is a major consideration in food preparation, diet selection and reasonable control for meat consumption. In livestock “Pharming” the danger of heavy metal contamination of commercial feed poses threat to human health aside from drug residues. It is proposed that the 50% of global greenhouse gas is due to the lifestyle of the rich and epidemic of obesity-related diseases are the effect of livestock “Pharming” and addiction to fast food and or processed meat.

  14. Rock-Mechanics Research. A Survey of United States Research to 1965, with a Partial Survey of Canadian Universities.

    National Academy of Sciences - National Research Council, Washington, DC.

    The results of a survey, conducted by the Committee on Rock Mechanics, to determine the status of training and research in rock mechanics in presented in this publication. In 1964 and 1965 information was gathered by questionnaires sent to industries, selected federal agencies, and universities in both the United States and Canada. Results are…

  15. Calculating the Unit Cost Factors for Decommissioning Cost Estimation of the Nuclear Research Reactor

    Jeong, Kwan Seong; Lee, Dong Gyu; Jung, Chong Hun; Lee, Kune Woo

    2006-01-01

    The estimated decommissioning cost of nuclear research reactor is calculated by applying a unit cost factor-based engineering cost calculation method on which classification of decommissioning works fitted with the features and specifications of decommissioning objects and establishment of composition factors are based. Decommissioning cost of nuclear research reactor is composed of labor cost, equipment and materials cost. Labor cost of decommissioning costs in decommissioning works are calculated on the basis of working time consumed in decommissioning objects. In this paper, the unit cost factors and work difficulty factors which are needed to calculate the labor cost in estimating decommissioning cost of nuclear research reactor are derived and figured out.

  16. FFUSION yearbook 1997. Annual report of the Finnish fusion research unit. Association EURATOM-TEKES

    Karttunen, S; Paettikangas, T [eds.; VTT Energy, Espoo (Finland)

    1998-02-01

    Finnish fusion programme (FFUSION) is one of the eleven national energy research programmes funded by the Technological Development Centre of Finland (TEKES). The FFUSION programme was fully integrated into European Fusion Programme just after Finland joined the European Union. The contract of Association Euratom and Tekes was signed in 1995 and extends to the end of 1999. Finland became a member of JET Joint Undertaking in 1996, other contracts with Euratom include NET agreement and the Staff Mobility Agreement. FFUSION programme with participating research institutes and universities forms the Fusion Research Unit of the Association Euratom-Tekes. This annual report summarises the research activities of the Finnish Research Unit in 1997. The programme consists of two parts: Physics and Technology. The research areas of the physics are: Fusion plasma engineering, and Radio-frequency heating and Plasma diagnostics. The technology is focused into three areas: Fusion reactor materials (first wall components and joining techniques), Remote handling and viewing systems, and Superconductors

  17. Job satisfaction and importance for intensive care unit research coordinators: results from binational survey.

    Rickard, Claire M; Roberts, Brigit L; Foote, Jonathon; McGrail, Matthew R

    2007-09-01

    To measure Intensive Care Unit Research coordinator job satisfaction and importance and to identify priorities for role development. Research coordinator numbers are growing internationally in response to increasing clinical research activity. In Australia, 1% of registered nurses work principally in research, many as Research coordinators. Internationally, the Association of Clinical Research Professionals currently has 6536 certified Research coordinators in 13 countries, with likely additional large numbers practicing without the voluntary certification. Research coordinators are almost always nurses, but little is know about this emerging specialty. Design. Cross-sectional study using anonymous self-report questionnaire. After ethics approval, the McCloskey-Mueller Satisfaction Scale and McCloskey-Mueller Importance Scale were administered via the Internet. The sample was 49 (response rate 71%) Research coordinators from the Australia and New Zealand Intensive Care Unit Research coordinators' Interest Group. Research coordinators were satisfied with structural aspects of the position working business hours; flexibility of working hours; high levels of responsibility and control over their work. Dissatisfaction was expressed regarding: remuneration and recognition; compensation for weekend work; salary package; career advancement opportunities; and childcare facilities. High priorities for role development are those rated highly important but with much lower satisfaction. These are: compensation for weekend call-out work; salary and remuneration package; recognition by management and clinicians; career advancement opportunities; departmental research processes; encouragement and feedback; and number of working hours. Increasing numbers of nurses have been attracted to this clinically based research position. These data contribute to the understanding and development of the role.

  18. Making Research Matter Comment on "Public Spending on Health Service and Policy Research in Canada, the United Kingdom, and the United States: A Modest Proposal".

    Hunter, David J; Frank, John

    2017-08-13

    We offer a UK-based commentary on the recent "Perspective" published in IJHPM by Thakkar and Sullivan. We are sympathetic to the authors' call for increased funding for health service and policy research (HSPR). However, we point out that increasing that investment - in any of the three countries they compare: Canada, the United States and the United Kingdom- will ipso facto not necessarily lead to any better use of research by health system decision-makers in these settings. We cite previous authors' descriptions of the many factors that tend to make the worlds of researchers and decision-makers into "two solitudes." And we call for changes in the structure and funding of HSPR, particularly the incentives now in place for purely academic publishing, to tackle a widespread reality: most published research in HSPR, as in other applied fields of science, is never read or used by the vast majority of decision-makers, working out in the "real world. © 2018 The Author(s); Published by Kerman University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

  19. Cooperative Fish and Wildlife Research Units Program—2017 year in review

    Organ, John F.; Thompson, John D.; Dennerline, Donald E.; Childs, Dawn E.

    2018-02-08

    The Cooperative Fish and Wildlife Research Units Program was involved in a number of notable events during 2017, many concerning our personnel. Dr. Barry Grand left his position as Leader of the Alabama Cooperative Fish and Wildlife Research Unit to become the Cooperative Units Program Supervisor for the South, replacing Dr. Kevin Whalen who took over as Supervisor for the West. We welcomed Dr. Sarah Converse who left the Patuxent Wildlife Research Center to become Leader of the Washington Cooperative Fish and Wildlife Research Unit. Dr. Amanda Rosenberger joined the Tennessee Cooperative Fishery Research Unit as Assistant Leader, transferring from the Missouri Cooperative Unit. Dr. Scott Carleton left his position as Assistant Unit Leader in New Mexico to become Chief of the Region 2 Migratory Bird Program of the U.S. Fish and Wildlife Service.We said farewell to many colleagues who retired. Their departure is bittersweet as we wish them health, happiness, and wellness in retirement. We will miss their companionship and the extraordinary contributions they have made to the Cooperative Fish and Wildlife Research Units Program and conservation.The Cooperative Fish and Wildlife Research Units Program has a record high number of vacant scientist positions due to a combination of retirements and base funding short-falls. These issues are affecting our ability to meet cooperator needs. Yet, we remain highly productive. For example, this year we released a report (https://doi.org/10.3133/cir1427) containing abstracts of nearly 600 of our research projects, covering thematic areas ranging from advanced technologies to wildlife diseases. We provided highly competent, trained scientists and natural resource managers for our cooperators’ workforce. We delivered technical training and guidance to professional practitioners. We provided critical information to cooperators for decisions on species status assessments and management of species of greatest conservation need

  20. Molecular Basis of Microbial One-Carbon Metabolism 2008 Gordon Research Conference (July 20-25, 2008)

    Stephen W. Ragsdale

    2009-08-12

    One-carbon (C-1) compounds play a central role in microbial metabolism. C-1 compounds include methane, carbon monoxide, CO2, and methanol as well as coenzyme-bound one-carbon compounds (methyl-B12, CH3-H4folate, etc). Such compounds are of broad global importance because several C-1 compounds (e.g., CH4) are important energy sources, some (e.g., CO2 and CH4) are potent greenhouse gases, and others (e.g., CH2Cl2) are xenobiotics. They are central in pathways of energy metabolism and carbon fixation by microbes and many are of industrial interest. Research on the pathways of one-carbon metabolism has added greatly to our understanding of evolution, structural biology, enzyme mechanisms, gene regulation, ecology, and applied biology. The 2008 meeting will include recent important findings in the following areas: (a) genomics, metagenomics, and proteomic studies that have expanded our understanding of autotrophy and C-1 metabolism and the evolution of these pathways; (b) redox regulation of carbon cycles and the interrelationship between the carbon cycle and other biogeochemical cycles (sulfur, nitrogen, oxygen); (c) novel pathways for carbon assimilation; (d) biotechnology related to C-1 metabolism; (e) novel enzyme mechanisms including channeling of C-1 intermediates during metabolism; and (f) the relationship between metal homeostasis and the global carbon cycle. The conference has a diverse and gender-balanced slate of speakers and session leaders. The wide variety of disciplines brought to the study of C-1 metabolism make the field an excellent one in which to train young researchers.

  1. Analysis of biotechnological hydrogen production efficiency for microorganisms with different types of metabolism, promising directions for further research

    Людмила Сергіївна Зубченко

    2015-10-01

    Full Text Available The basic biotechnological methods of hydrogen production, namely biological water splitting, using algae or cyanobacteria, dark fermentation and bioelectrochemical systems are analyzed in the article. Biochemical features of hydrogen production by microorganisms with different types of metabolism are reviewed. Disadvantages of each method and the prospects for future research are determined

  2. United States Department of Agriculture-Agricultural Research Service research in application technology for pest management.

    Smith, L A; Thomson, S J

    2003-01-01

    A research summary is presented that emphasizes ARS achievements in application technology over the past 2-3 years. Research focused on the improvement of agricultural pesticide application is important from the standpoint of crop protection as well as environmental safety. Application technology research is being actively pursued within the ARS, with a primary focus on application system development, drift management, efficacy enhancement and remote sensing. Research on application systems has included sensor-controlled hooded sprayers, new approaches to direct chemical injection, and aerial electrostatic sprayers. For aerial application, great improvements in on-board flow controllers permit accurate field application of chemicals. Aircraft parameters such as boom position and spray release height are being altered to determine their effect on drift. Other drift management research has focused on testing of low-drift nozzles, evaluation of pulsed spray technologies and evaluation of drift control adjuvants. Research on the use of air curtain sprayers in orchards, air-assist sprayers for row crops and vegetables, and air deflectors on aircraft has documented improvements in application efficacy. Research has shown that the fate of applied chemicals is influenced by soil properties, and this has implications for herbicide efficacy and dissipation in the environment. Remote sensing systems are being used to target areas in the field where pests are present so that spray can be directed to only those areas. Soil and crop conditions influence propensity for weeds and insects to proliferate in any given field area. Research has indicated distinct field patterns favorable for weed growth and insect concentration, which can provide further assistance for targeted spraying.

  3. The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors.

    Goodarz Danaei

    2009-04-01

    Full Text Available Knowledge of the number of deaths caused by risk factors is needed for health policy and priority setting. Our aim was to estimate the mortality effects of the following 12 modifiable dietary, lifestyle, and metabolic risk factors in the United States (US using consistent and comparable methods: high blood glucose, low-density lipoprotein (LDL cholesterol, and blood pressure; overweight-obesity; high dietary trans fatty acids and salt; low dietary polyunsaturated fatty acids, omega-3 fatty acids (seafood, and fruits and vegetables; physical inactivity; alcohol use; and tobacco smoking.We used data on risk factor exposures in the US population from nationally representative health surveys and disease-specific mortality statistics from the National Center for Health Statistics. We obtained the etiological effects of risk factors on disease-specific mortality, by age, from systematic reviews and meta-analyses of epidemiological studies that had adjusted (i for major potential confounders, and (ii where possible for regression dilution bias. We estimated the number of disease-specific deaths attributable to all non-optimal levels of each risk factor exposure, by age and sex. In 2005, tobacco smoking and high blood pressure were responsible for an estimated 467,000 (95% confidence interval [CI] 436,000-500,000 and 395,000 (372,000-414,000 deaths, accounting for about one in five or six deaths in US adults. Overweight-obesity (216,000; 188,000-237,000 and physical inactivity (191,000; 164,000-222,000 were each responsible for nearly 1 in 10 deaths. High dietary salt (102,000; 97,000-107,000, low dietary omega-3 fatty acids (84,000; 72,000-96,000, and high dietary trans fatty acids (82,000; 63,000-97,000 were the dietary risks with the largest mortality effects. Although 26,000 (23,000-40,000 deaths from ischemic heart disease, ischemic stroke, and diabetes were averted by current alcohol use, they were outweighed by 90,000 (88,000-94,000 deaths from

  4. Current researches on safety assessment of radioactive waste disposal in the United States

    Tasaka, Hiroshi; Kiyose, Ryohei

    1980-01-01

    Recently, the problem of safe disposal of radioactive waste generated from nuclear fuel cycle becomes more important in Japan. On the other hand, many researches on shallow land burial of low-level wastes and geologic isolation of high-level wastes have been carried out in the United States of America. In this report, the researches on the safety assessment of radioactive waste disposal in the United States of America were briefly introduced with emphasis on the studies on behavior and migration of radionuclide from disposed waste in geosphere. (author)

  5. The United States Culture Collection Network (USCCN): Enhancing Microbial Genomics Research through Living Microbe Culture Collections

    Boundy-Mills, Kyria; Hess, Matthias; Bennett, A. Rick; Ryan, Matthew; Kang, Seogchan; Nobles, David; Eisen, Jonathan A.; Inderbitzin, Patrik; Sitepu, Irnayuli R.; Torok, Tamas; Brown, Daniel R.; Cho, Juliana; Wertz, John E.; Mukherjee, Supratim; Cady, Sherry L.

    2015-01-01

    The mission of the United States Culture Collection Network (USCCN; http://usccn.org) is “to facilitate the safe and responsible utilization of microbial resources for research, education, industry, medicine, and agriculture for the betterment of human kind.” Microbial culture collections are a key component of life science research, biotechnology, and emerging global biobased economies. Representatives and users of several microbial culture collections from the United States and Europe gathered at the University of California, Davis, to discuss how collections of microorganisms can better serve users and stakeholders and to showcase existing resources available in public culture collections. PMID:26092453

  6. Salamander chytrid fungus (Batrachochytrium salamandrivorans) in the United States—Developing research, monitoring, and management strategies

    Grant, Evan H. Campbell; Muths, Erin L.; Katz, Rachel A.; Canessa, Stefano; Adams, Michael J.; Ballard, Jennifer R.; Berger, Lee; Briggs, Cheryl J.; Coleman, Jeremy; Gray, Matthew J.; Harris, M. Camille; Harris, Reid N.; Hossack, Blake R.; Huyvaert, Kathryn P.; Kolby, Jonathan E.; Lips, Karen R.; Lovich, Robert E.; McCallum, Hamish I.; Mendelson, Joseph R.; Nanjappa, Priya; Olson, Deanna H.; Powers, Jenny G.; Richgels, Katherine L. D.; Russell, Robin E.; Schmidt, Benedikt R.; Spitzen-van der Sluijs, Annemarieke; Watry, Mary Kay; Woodhams, Douglas C.; White, C. LeAnn

    2016-01-20

    The recently (2013) identified pathogenic chytrid fungus, Batrachochytrium salamandrivorans (Bsal), poses a severe threat to the distribution and abundance of salamanders within the United States and Europe. Development of a response strategy for the potential, and likely, invasion of Bsal into the United States is crucial to protect global salamander biodiversity. A formal working group, led by Amphibian Research and Monitoring Initiative (ARMI) scientists from the U.S. Geological Survey (USGS) Patuxent Wildlife Research Center, Fort Collins Science Center, and Forest and Rangeland Ecosystem Science Center, was held at the USGS Powell Center for Analysis and Synthesis in Fort Collins, Colorado, United States from June 23 to June 25, 2015, to identify crucial Bsal research and monitoring needs that could inform conservation and management strategies for salamanders in the United States. Key findings of the workshop included the following: (1) the introduction of Bsal into the United States is highly probable, if not inevitable, thus requiring development of immediate short-term and long-term intervention strategies to prevent Bsal establishment and biodiversity decline; (2) management actions targeted towards pathogen containment may be ineffective in reducing the long-term spread of Bsal throughout the United States; and (3) early detection of Bsal through surveillance at key amphibian import locations, among high-risk wild populations, and through analysis of archived samples is necessary for developing management responses. Top research priorities during the preinvasion stage included the following: (1) deployment of qualified diagnostic methods for Bsal and establishment of standardized laboratory practices, (2) assessment of susceptibility for amphibian hosts (including anurans), and (3) development and evaluation of short- and long-term pathogen intervention and management strategies. Several outcomes were achieved during the workshop, including development

  7. Review of the research proposal for the steam generator retired from Kori unit 1

    Kim, Joung Soo; Han, Joung Ho; Kim, Hong Pyo; Lim, Yun Soo; Lee, Deok Hyun; Hwang, Seong Sik; Hur, Do Haeng [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2002-03-01

    The tubes of the steam generator retired form Kori unit 1 have many different kinds of failures, such as denting pitting, wastage, ODSCC, PWSCC.Korea Electric Power Research Institute (KEPRI) submitted a research proposal for the steam generator to the Korea Institute S and T Evaluation and Planning (KSITEP). The KISTEP requested Korea Atomic Energy Research Institute to review the proposal by organizing a committee which should be composed of the specialists of the related domestic research institutes. Opinions of the committee on the objectives, research fields, economic benefit and validity in the research proposal were reviewed and suggested optimal research fields to be fulfilled successfully for the retired steam generator. Also, the rolls for the participants in the research works were allocated, which is critical in order to do the project effectively. 6 figs., 5 tabs. (Author)

  8. The NIHR Public Health Research Programme: responding to local authority research needs in the United Kingdom.

    Dorling, Hannah; Cook, Andrew; Ollerhead, Liz; Westmore, Matt

    2015-12-11

    The remit of the National Institute for Health Research Public Health Research (PHR) Programme is to evaluate public health interventions, providing new knowledge on the benefits, costs, acceptability and wider impacts of interventions, set outside of the National Health Service, intended to improve the health of the public and reduce inequalities. This paper illustrates how the PHR Programme is providing new knowledge for public health decision makers, based on the nine key areas for local authority public health action, described by the King's Fund. Many funded PHR projects are evaluating interventions, applied in a range of settings, across the identified key areas for local authority influence. For example, research has been funded on children and young people, and for some of the wider determinants of health, such as housing and travel. Other factors, such as spatial planning, or open and green spaces and leisure, are less represented in the PHR Programme. Further opportunities in research include interventions to improve the health of adolescents, adults in workplaces, and communities. Building evidence for public health interventions at local authority level is important to prioritise and implement effective changes to improve population health.

  9. The Cerebral Palsy Research Registry: Development and Progress Toward National Collaboration in the United States

    Hurley, Donna S.; Sukal-Moulton, Theresa; Msall, Michael E.; Gaebler-Spira, Deborah; Krosschell, Kristin J.; Dewald, Julius P.

    2011-01-01

    Cerebral palsy is the most common neurodevelopmental motor disability in children. The condition requires medical, educational, social, and rehabilitative resources throughout the life span. Several countries have developed population-based registries that serve the purpose of prospective longitudinal collection of etiologic, demographic, and functional severity. The United States has not created a comprehensive program to develop such a registry. Barriers have been large population size, poor interinstitution collaboration, and decentralized medical and social systems. The Cerebral Palsy Research Registry was created to fill the gap between population and clinical-based cerebral palsy registries and promote research in the field. This is accomplished by connecting persons with cerebral palsy, as well as their families, to a network of regional researchers. This article describes the development of an expandable cerebral palsy research registry, its current status, and the potential it has to affect families and persons with cerebral palsy in the United States and abroad. PMID:21677201

  10. Cooperative Fish and Wildlife Research Units Program—2017 year in review postcard

    Organ, John F.; Thompson, John D.; Dennerline, Donald E.; Childs, Dawn E.

    2018-02-08

    This postcard provides details about the Cooperative Fish and Wildlife Research Units Program—2017 Year in Review, U.S. Geological Survey Circular 1438, now available at https://doi.org/10.3133/cir1438. In this report, you will find details about the Cooperative Fish and Wildlife Research Units (CRU) Program relating to its background, fish and wildlife science, students, staffing, vacancies, research funding, outreach and training, science themes, accolades, and professional services. You will see snapshots of CRU projects with information on how results have been or are being applied by cooperators. This is the essence of what we do: science that matters.Throughout the year, keep up with CRU research projects at http://www.coopunits.org.

  11. Inherited metabolic disorders in Thailand.

    Wasant, Pornswan; Svasti, Jisnuson; Srisomsap, Chantragan; Liammongkolkul, Somporn

    2002-08-01

    The study of inborn errors of metabolism (IEM) in Thailand is in its infancy. The majority are clinically diagnosed since there are only a handful of clinicians and scientists with expertise in inherited metabolic disorders, shortage of well-equipped laboratory facilities and lack of governmental financial support. Genetic metabolic disorders are usually not considered a priority due to prevalence of infectious diseases and congenital infections. From a retrospective study at the Medical Genetics Unit, Department of Pediatrics, Siriraj Hospital; estimated pediatrics patients with suspected IEM were approximately 2-3 per cent of the total pediatric admissions of over 5,000 annually. After more than 10 years of research and accumulated clinical experiences, a genetic metabolic center is being established in collaboration with expert laboratories both in Bangkok (Chulabhorn Research Institute) and abroad (Japan and the United States). Numerous inherited metabolic disorders were identified--carbohydrate, amino acids, organic acids, mitochondrial fatty acid oxidation, peroxisomal, mucopolysaccharidoses etc. This report includes the establishment of genetic metabolic center in Thailand, research and pilot studies in newborn screening in Thailand and a multicenter study from 5 institutions (Children's National Center, King Chulalongkorn Memorial Hospital, Pramongkutklao Hospital, Ramathibodi and Siriraj Hospitals). Inherited metabolic disorders reported are fructose-1,6-bisphosphatase deficiency, phenylketonuria, homocystinuria, nonketotic hyperglycinemia, urea cycle defect (arginino succinate lyase deficiency, argininosuccinate synthetase deficiency), Menkes disease, propionic acidemia and mucopolysaccharidoses (Hurler, Hurler-Scheie).

  12. A Status Report on the Global Research in Microbial Metabolic Engineering

    Joe, Min Ho; Lim, Sang Yong; Kim, Dong Ho

    2008-09-15

    Biotechnology industry is now a global 'Mega-Trend' and metabolic engineering technology has important role is this area. Therefore, many countries has made efforts in this field to produce top value added bio-products efficiently using microorganisms. It has been applied to increase the production of chemicals that are already produced by the host organism, to produce desired chemical substances from less expensive feedstock, and to generate products that are new to the host organism. Recent experimental advances, the so-called '-omics' technologies, mainly functional genomics, proteomics and metabolomics, have enabled wholesale generation of new genomic, transcriptomic, proteomic, and metabolomic data. This report provides the insights of the integrated view of metabolism generated by metabolic engineering for biotechnological applications of microbial metabolic engineering.

  13. A Status Report on the Global Research in Microbial Metabolic Engineering

    Joe, Min Ho; Lim, Sang Yong; Kim, Dong Ho

    2008-09-01

    Biotechnology industry is now a global 'Mega-Trend' and metabolic engineering technology has important role is this area. Therefore, many countries has made efforts in this field to produce top value added bio-products efficiently using microorganisms. It has been applied to increase the production of chemicals that are already produced by the host organism, to produce desired chemical substances from less expensive feedstock, and to generate products that are new to the host organism. Recent experimental advances, the so-called '-omics' technologies, mainly functional genomics, proteomics and metabolomics, have enabled wholesale generation of new genomic, transcriptomic, proteomic, and metabolomic data. This report provides the insights of the integrated view of metabolism generated by metabolic engineering for biotechnological applications of microbial metabolic engineering

  14. A Status Report on the Global Research in Microbial Metabolic Engineering

    Joe, Min Ho; Lim, Sang Yong; Kim, Dong Ho

    2008-09-15

    Biotechnology industry is now a global 'Mega-Trend' and metabolic engineering technology has important role is this area. Therefore, many countries has made efforts in this field to produce top value added bio-products efficiently using microorganisms. It has been applied to increase the production of chemicals that are already produced by the host organism, to produce desired chemical substances from less expensive feedstock, and to generate products that are new to the host organism. Recent experimental advances, the so-called '-omics' technologies, mainly functional genomics, proteomics and metabolomics, have enabled wholesale generation of new genomic, transcriptomic, proteomic, and metabolomic data. This report provides the insights of the integrated view of metabolism generated by metabolic engineering for biotechnological applications of microbial metabolic engineering.

  15. The Need for Comparative Education Research to Concentrate on the Cultural Revolution within the United States.

    Petit, M. Loretta

    Comparative education research and courses are needed to identify real revolutionary movements in the current cultural revolution in the United States. The presence of cultural revolution is indicated by, among other things, the development of microcultures. Intranational instead of cross-national studies are of importance in the next few years to…

  16. Research Directions: Multimodal Books in Science-Literacy Units: Language and Visual Images for Meaning Making

    Pappas, Christine C.; Varelas, Maria

    2009-01-01

    This article presents a review of the author's long-term research in urban classrooms. The authors explore six illustrated information books created by children as culminating activities of integrated science-literacy units, Forest and Matter, that they developed, implemented, and studied in several 1st-3rd grade classrooms in Chicago Public…

  17. United States of America. Report 1 [Marine Radioecology. Current Research and Future Scope

    Nakatani, R.E.

    1967-01-01

    Biology Department's aquatic research activities are primarily in freshwater radioecology and not in marine radioecology. The major reason for this lack of marine work is geographical location of our laboratory on the banks of the Columbia River, roughly 300 miles from the ocean. Recently, however, we have completed some preliminary work with 65 Zn metabolism in Anonyx sp., a marine benthic amphipod. Lake some inland laboratories, we have found that limited marine work can be done by hauling in sea water. We have been able to maintain the amphipods in a reasonably healthy state in our laboratory for about four weeks

  18. United States Air Force Research Initiation Program. 1984 Research Reports. Volume 3.

    1986-05-01

    right terminal of lamp 13. Position the second switch below switch A such that the handle may be pulled toward you or pushed away from you. The second...position. 42. Pull the handle of s.itch B toward you to light lamp B. 47. Fush.the handle of switch B all the way forward to light both lamps A and B... goalI was to obtain information that could lead to the stabilization of a . Nd:YAG laser. III. APPROACH At the beginning of this research, some of the

  19. Challenges and strategies for quantitative and qualitative field research in the United Arab Emirates.

    Aw, Tar-Ching; Zoubeidi, Taoufik; Al-Maskari, Fatma; Blair, Iain

    2011-01-01

    Clinical and public health research depends on factors including national systems, socio-cultural influences, and access to organisations and individuals. As a 'new' country, the United Arab Emirates (UAE) has yet to develop strong support for population research. However, there is interest in research. The challenges for quantitative and qualitative research include the varied composition and mobility of the UAE population, with limited health records and disease registries. Long-term follow-up of patients, and tracing foreign workers who may only be in the UAE for a few years, are two major obstacles for longitudinal studies. There can also be a reluctance shown by parts of the population to participate in studies, especially those that require responding to what is perceived as sensitive questions. Successful execution of population research in the UAE requires an understanding of socio-cultural aspects of the study population, and good communication between researchers and participants.

  20. Research on unit commitment with large-scale wind power connected power system

    Jiao, Ran; Zhang, Baoqun; Chi, Zhongjun; Gong, Cheng; Ma, Longfei; Yang, Bing

    2017-01-01

    Large-scale integration of wind power generators into power grid brings severe challenges to power system economic dispatch due to its stochastic volatility. Unit commitment including wind farm is analyzed from the two parts of modeling and solving methods. The structures and characteristics can be summarized after classification has been done according to different objective function and constraints. Finally, the issues to be solved and possible directions of research and development in the future are discussed, which can adapt to the requirements of the electricity market, energy-saving power generation dispatching and smart grid, even providing reference for research and practice of researchers and workers in this field.

  1. [Ethics of research in psychiatry. Comparison of France and the United States].

    Lemoine, P; Pacault-Legendre, V

    1983-01-01

    This article presents a comparison of research ethics in psychopharmacology in France and the United States. The authors present some elements of definition, etymology and of history. In addition, they study how this very specific research is actually done. Many questions are discussed, including the right of the patient, and the problem of normal volunteers. Other aspects are more technical i.e. remuneration, protocol, and the product. Finally the role of the ethics committees is investigated. These committees comprise the third component of the trial that consists of the research and the subject.

  2. Product- and Process Units in the CRITT Translation Process Research Database

    Carl, Michael

    than 300 hours of text production. The database provides the raw logging data, as well as Tables of pre-processed product- and processing units. The TPR-DB includes various types of simple and composed product and process units that are intended to support the analysis and modelling of human text......The first version of the "Translation Process Research Database" (TPR DB v1.0) was released In August 2012, containing logging data of more than 400 translation and text production sessions. The current version of the TPR DB, (v1.4), contains data from more than 940 sessions, which represents more...

  3. Developing nursing research in the United Arab Emirates: a narrative review.

    McCreaddie, M; Kuzemski, D; Griffiths, J; Sojka, E M; Fielding, M; Al Yateem, N; Williams, J J

    2018-03-01

    This article identified, critically analysed and synthesized the literature on international nursing and midwifery research capacity building and standards. The United Arab Emirates is heavily dependent up on expatriate nurses. Only 4% of nurses working within the country are Emirati. The nation is therefore committed to developing nurses and nursing as a profession. The United Arab Emirates' Nursing and Midwifery Council was formed in 2009 and initially focused on regulation, education and specialization. This review was undertaken to inform the work of the Council's newly established Scientific Research Sub-Committee. A rapid narrative review was conducted using the Cumulative Index of Nursing and Allied Health Literature database, key words, Boolean operators, parameters and a journal-specific search. An inclusion/exclusion criterion was identified. The search provided 332 articles with 45 included in the final review. The literature on nursing research 'standards' and 'capacity building' is diverse and inconsistent across continents and in approaches. Nursing research has evolved to varying degrees across the globe. Nevertheless, irrespective of the locale, there are similar problems encountered in growing research, for example nursing faculty shortage, lack of collaborative research, funding. There are also specific challenges in the Middle East and North Africa region. The review was constrained by time and access. There are specific challenges for the United Arab Emirates. However, the country is well placed to learn from the experiences of colleagues elsewhere. Time and commitment is required to build the solid foundations necessary to ensure robust, sustained growth. Identifying research capacity as both a process and outcome at the outset may also assist. Further, it may be prudent to consider initiating a Gulf Coast Countries' collaborative approach to building research capacity to harness scare resources and create a larger critical mass. © 2017

  4. FINAL INTERIM REPORT VERIFICATION SURVEY ACTIVITIES IN FINAL STATUS SURVEY UNITS 7, 8, 9, 10, 11, 13 and 14 AT THE SEPARATIONS PROCESS RESEARCH UNIT, NISKAYUNA, NEW YORK

    Jadick, M.G.

    2010-01-01

    The Separations Process Research Unit (SPRU) facilities were constructed in the late 1940s to research the chemical separation of plutonium and uranium. SPRU operated between February 1950 and October 1953. The research activities ceased following the successful development of the reduction/oxidation and plutonium/uranium extraction processes that were subsequently used by the Hanford and the Savannah River sites.

  5. A continuing success - The United States Foreign Research Reactor Spent Nuclear Fuel Acceptance Program

    Mustin, Tracy P.; Clapper, Maureen; Reilly, Jill E.

    2000-01-01

    The United States Department of Energy, in consultation with the Department of State, adopted the Nuclear Weapons Nonproliferation Policy Concerning Foreign Research Reactor Spent Nuclear Fuel in May 1996. To date, the Foreign Research Reactor (FRR) Spent Nuclear Fuel (SNF) Acceptance Program, established under this policy, has completed 16 spent fuel shipments. 2,651 material test reactor (MTR) assemblies, one Slowpoke core containing less than 1 kilogram of U.S.-origin enriched uranium, 824 Training, Research, Isotope, General Atomic (TRIGA) rods, and 267 TRIGA pins from research reactors around the world have been shipped to the United States so far under this program. As the FRR SNF Acceptance Program progresses into the fifth year of implementation, a second U.S. cross country shipment has been completed, as well as a second overland truck shipment from Canada. Both the cross country shipment and the Canadian shipment were safely and successfully completed, increasing our knowledge and experience in these types of shipments. In addition, two other shipments were completed since last year's RERTR meeting. Other program activities since the last meeting included: taking pre-emptive steps to avoid license amendment pitfalls/showstoppers for spent fuel casks, publication of a revision to the Record of Decision allowing up to 16 casks per ocean going vessel, and the issuance of a cable to 16 of the 41 eligible countries reminding their governments and the reactor operators that the U.S.-origin uranium in their research reactors may be eligible for return to the United States under the Acceptance Program and urging them to begin discussions on shipping schedules. The FRR SNF program has also supported the Department's implementation of the competitive pricing policy for uranium and resumption of shipments of fresh uranium for fabrication into assemblies for research reactors. The United States Foreign Research Reactor Spent Nuclear Fuel Acceptance Program continues

  6. U.S. Geological Survey Cooperative Fish and Wildlife Research Units Program—2016–2017 Research Abstracts

    Dennerline, Donald E.; Childs, Dawn E.

    2017-04-20

    The U.S. Geological Survey (USGS) has several strategic goals that focus its efforts on serving the American people. The USGS Ecosystems Mission Area has responsibility for the following objectives under the strategic goal of “Science to Manage and Sustain Resources for Thriving Economies and Healthy Ecosystems”:Understand, model, and predict change in natural systemsConserve and protect wildlife and fish species and their habitatsReduce or eliminate the threat of invasive species and wildlife diseaseThis report provides abstracts of the majority of ongoing research investigations of the USGS Cooperative Fish and Wildlife Research Units program and is intended to complement the 2016 Cooperative Research Units Program Year in Review Circular 1424 (https://doi.org/10.3133/cir1424). The report is organized by the following major science themes that contribute to the objectives of the USGS:Advanced TechnologiesClimate ScienceDecision ScienceEcological FlowsEcosystem ServicesEndangered Species Conservation, Recovery, and Proactive StrategiesEnergyHuman DimensionsInvasive SpeciesLandscape EcologySpecies of Greatest Conservation NeedSpecies Population, Habitat, and Harvest ManagementWildlife Health and Disease

  7. Ethnographic research into nursing in acute adult mental health units: a review.

    Cleary, Michelle; Hunt, Glenn E; Horsfall, Jan; Deacon, Maureen

    2011-01-01

    Acute inpatient mental health units are busy and sometimes chaotic settings, with high bed occupancy rates. These settings include acutely unwell patients, busy staff, and a milieu characterised by unpredictable interactions and events. This paper is a report of a literature review conducted to identify, analyse, and synthesize ethnographic research in adult acute inpatient mental health units. Several electronic databases were searched using relevant keywords to identify studies published from 1990-present. Additional searches were conducted using reference lists. Ethnographic studies published in English were included if they investigated acute inpatient care in adult settings. Papers were excluded if the unit under study was not exclusively for patients in the acute phase of their mental illness, or where the original study was not fully ethnographic. Ten research studies meeting our criteria were found (21 papers). Findings were grouped into the following overarching categories: (1) Micro-skills; (2) Collectivity; (3) Pragmatism; and (4) Reframing of nursing activities. The results of this ethnographic review reveal the complexity, patient-orientation, and productivity of some nursing interventions that may not have been observed or understood without the use of this research method. Additional quality research should focus on redefining clinical priorities and philosophies to ensure everyday care is aligned constructively with the expectations of stakeholders and is consistent with policy and the realities of the organisational setting. We have more to learn from each other with regard to the effective nursing care of inpatients who are acutely disturbed.

  8. Impact of hypoxia and the metabolic microenvironment on radiotherapy of solid tumors. Introduction of a multiinstitutional research project

    Zips, D.; Petersen, C.; Adam, M.; Molls, M.; Philbrook, C.; Flentje, M.; Haase, A.; Schmitt, P.; Mueller-Klieser, W.; Thews, O.; Walenta, S.; Baumann, M.

    2004-01-01

    Background: recent developments in imaging technology and tumor biology have led to new techniques to detect hypoxia and related alterations of the metabolic microenvironment in tumors. However, whether these new methods can predict radiobiological hypoxia and outcome after fractionated radiotherapy still awaits experimental evaluation. Material and methods: the present article will introduce a multiinstitutional research project addressing the impact of hypoxia and the metabolic microenvironment on radiotherapy of solid tumors. The four laboratories involved are situated at the universities of Dresden, Mainz, Munich and Wuerzburg, Germany. Results: the joint scientific project started to collect data obtained on a set of ten different human tumor xenografts growing in nude mice by applying various imaging techniques to detect tumor hypoxia and related parameters of the metabolic microenvironment. These techniques include magnetic resonance imaging and spectroscopy, metabolic mapping with quantitative bioluminescence and single-photon imaging, histological multiparameter analysis of biochemical hypoxia, perfusion and vasculature, and immunohistochemistry of factors related to angiogenesis, invasion and metastasis. To evaluate the different methods, baseline functional radiobiological data including radiobiological hypoxic fraction and outcome after fractionated irradiation will be determined. Conclusion: besides increasing our understanding of tumor biology, the project will focus on new, clinically applicable strategies for microenvironment profiling and will help to identify those patients that might benefit from targeted interventions to improve tumor oxygenation. (orig.)

  9. United States private-sector physicians and pharmaceutical contract research: a qualitative study.

    Fisher, Jill A; Kalbaugh, Corey A

    2012-01-01

    There have been dramatic increases over the past 20 years in the number of nonacademic, private-sector physicians who serve as principal investigators on US clinical trials sponsored by the pharmaceutical industry. However, there has been little research on the implications of these investigators' role in clinical investigation. Our objective was to study private-sector clinics involved in US pharmaceutical clinical trials to understand the contract research arrangements supporting drug development, and specifically how private-sector physicians engaged in contract research describe their professional identities. We conducted a qualitative study in 2003-2004 combining observation at 25 private-sector research organizations in the southwestern United States and 63 semi-structured interviews with physicians, research staff, and research participants at those clinics. We used grounded theory to analyze and interpret our data. The 11 private-sector physicians who participated in our study reported becoming principal investigators on industry clinical trials primarily because contract research provides an additional revenue stream. The physicians reported that they saw themselves as trial practitioners and as businesspeople rather than as scientists or researchers. Our findings suggest that in addition to having financial motivation to participate in contract research, these US private-sector physicians have a professional identity aligned with an industry-based approach to research ethics. The generalizability of these findings and whether they have changed in the intervening years should be addressed in future studies. Please see later in the article for the Editors' Summary.

  10. United States private-sector physicians and pharmaceutical contract research: a qualitative study.

    Jill A Fisher

    Full Text Available There have been dramatic increases over the past 20 years in the number of nonacademic, private-sector physicians who serve as principal investigators on US clinical trials sponsored by the pharmaceutical industry. However, there has been little research on the implications of these investigators' role in clinical investigation. Our objective was to study private-sector clinics involved in US pharmaceutical clinical trials to understand the contract research arrangements supporting drug development, and specifically how private-sector physicians engaged in contract research describe their professional identities.We conducted a qualitative study in 2003-2004 combining observation at 25 private-sector research organizations in the southwestern United States and 63 semi-structured interviews with physicians, research staff, and research participants at those clinics. We used grounded theory to analyze and interpret our data. The 11 private-sector physicians who participated in our study reported becoming principal investigators on industry clinical trials primarily because contract research provides an additional revenue stream. The physicians reported that they saw themselves as trial practitioners and as businesspeople rather than as scientists or researchers.Our findings suggest that in addition to having financial motivation to participate in contract research, these US private-sector physicians have a professional identity aligned with an industry-based approach to research ethics. The generalizability of these findings and whether they have changed in the intervening years should be addressed in future studies. Please see later in the article for the Editors' Summary.

  11. FFUSION yearbook 1996. Annual report of the Finnish research unit. Association EURATOM-TEKES

    Karttunen, S; Paettikangas, T [eds.; VTT Energy, Espoo (Finland)

    1997-05-01

    Finnish fusion programme (FFUSION) is one of the eleven national energy research programmes funded by the Technological Development Centre of Finland (TEKES). The FFUSION programme was fully integrated into European Fusion Programme just after Finland joined the European Union. The contract of Association Euratom and Tekes was signed in 1995 and extends to the end of 1999. Finland became a member of JET Joint Undertaking in 1996, other contracts with Euratom include NET agreement and the Staff Mobility Agreement. FFUSION programme with participating research institutes and universities forms the Fusion Research Unit of the Association Euratom-Tekes. This annual report summarises the research activities of the Finnish Research Unit in 1996. The programme consists of two parts: Physics and Technology. The research areas of the physics are: Fusion plasma engineering, Radio-frequency heating and plasma diagnostics, and Plasma-wall interactions - ion-beam studies. The technology is focused into three areas: Fusion reactor materials (first wall components and joining techniques), Remote handling and viewing systems, and Superconductors

  12. The role of Clinical Trial Units in investigator- and industry-initiated research projects.

    von Niederhäusern, Belinda; Fabbro, Thomas; Pauli-Magnus, Christiane

    2015-01-01

    Six multidisciplinary competence centres (Clinical Trial Units, CTUs) in Basel, Berne, Geneva, Lausanne, St. Gallen and Zurich provide professional support to clinical researchers in the planning, implementation, conduct and evaluation of clinical studies. Through their coordinated network, these units promote high-quality, nationally harmonised and internationally standardised clinical research conduct in Switzerland. We will describe why this network has been established, how it has been successful in stilling the growing need for clinical research support, which training and education opportunities it offers, and how it created national awareness for the still-existing hurdles towards clinical research excellence in Switzerland. Taking the CTU Basel as an example, we show that a considerable number (25%) of the studies submitted for regulatory approval in 2013 were supported by the CTU, decreasing the number of findings in ethics reviews by about one-third. We conclude that these achievements, together with a Swiss national funding model for clinical research, and improved national coordination, will be critical factors to successfully position Swiss clinical research at the international forefront.

  13. Moving into the 21st century - The United States' Research Reactor Spent Nuclear Fuel Acceptance Program

    Huizenga, David G.; Mustin, Tracy P.; Saris, Elizabeth C.; Reilly, Jill E.

    1999-01-01

    Since 1996, when the United States Department of Energy and the Department of State jointly adopted the Nuclear Weapons Nonproliferation Policy Concerning Foreign Research Reactor Spent Nuclear Fuel, twelve shipments totaling 2,985 MTR and TRIGA spent nuclear fuel assemblies from research reactors around the world have been accepted into the United States. These shipments have contained approximately 1.7 metric tons of HEU and 0.6 metric tons of LEU. Foreign research reactor operators played a significant role in this success. A new milestone in the acceptance program occurred during the summer of 1999 with the arrival of TRIGA spent nuclear fuel from Europe through the Charleston Naval Weapons Station via the Savannah River Site to the Idaho National Engineering and Environmental Laboratory. This shipment consisted of five casks of TRIGA spent nuclear fuel from research reactors in Germany, Italy, Slovenia, and Romania. These casks were transported by truck approximately 2,400 miles across the United States (one cask packaged in an ISO container per truck). Drawing upon lessons learned in previous shipments, significant technical, legal, and political challenges were addressed to complete this cross-country shipment. Other program activities since the last RERTR meeting have included: formulation of a methodology to determine the quantity of spent nuclear fuel in a damaged condition that may be transported in a particular cask (containment analysis for transportation casks); publication of clarification of the fee policy; and continued planning for the outyears of the acceptance policy including review of reactors and eligible material quantities. The United States Foreign Research Reactor Spent Nuclear Fuel Acceptance Program continues to demonstrate success due to the continuing commitment between the United States and the research reactor community to make this program work. We strongly encourage all eligible research reactors to decide as soon as possible to

  14. Research on Key Technologies of Unit-Based CNC Machine Tool Assembly Design

    Zhongqi Sheng

    2014-01-01

    Full Text Available Assembly is the part that produces the maximum workload and consumed time during product design and manufacturing process. CNC machine tool is the key basic equipment in manufacturing industry and research on assembly design technologies of CNC machine tool has theoretical significance and practical value. This study established a simplified ASRG for CNC machine tool. The connection between parts, semantic information of transmission, and geometric constraint information were quantified to assembly connection strength to depict the assembling difficulty level. The transmissibility based on trust relationship was applied on the assembly connection strength. Assembly unit partition based on assembly connection strength was conducted, and interferential assembly units were identified and revised. The assembly sequence planning and optimization of parts in each assembly unit and between assembly units was conducted using genetic algorithm. With certain type of high speed CNC turning center, as an example, this paper explored into the assembly modeling, assembly unit partition, and assembly sequence planning and optimization and realized the optimized assembly sequence of headstock of CNC machine tool.

  15. The United States foreign research reactor spent nuclear fuel acceptance program: Proposal to modify the program

    Messick, C.E.

    2005-01-01

    The United States Department of Energy (DOE), in consultation with the Department of State (DOS), adopted the Nuclear Weapons Nonproliferation Policy Concerning Foreign Research Reactor Spent Nuclear Fuel in May 1996. The policy was slated to expire in May 2009. However, in October 2003, a petition requesting a program extension was delivered to the United States Secretary of Energy from a group of research reactor operators from foreign countries. In April 2004, the Secretary directed DOE undertake an analysis, as required by the National Environmental Policy Act (NEPA), to consider potential extension of the Program. On December 1, 2004, a Federal Register Notice was issued approving the program extension. This paper discusses the findings from the NEPA analysis and the potential changes in the program that may result from implementation of the proposed changes. (author)

  16. The Applied Meteorology Unit: Nineteen Years Successfully Transitioning Research Into Operations for America's Space Program

    Madura, John T.; Bauman, William H., III; Merceret, Francis J.; Roeder, William P.; Brody, Frank C.; Hagemeyer, Bartlett C.

    2011-01-01

    The Applied Meteorology Unit (AMU) provides technology development and transition services to improve operational weather support to America's space program . The AMU was founded in 1991 and operates under a triagency Memorandum of Understanding (MOU) between the National Aeronautics and Space Administration (NASA), the United States Air Force (USAF) and the National Weather Service (NWS) (Ernst and Merceret, 1995). It is colocated with the 45th Weather Squadron (45WS) at Cape Canaveral Air Force Station (CCAFS) and funded by the Space Shuttle Program . Its primary customers are the 45WS, the Spaceflight Meteorology Group (SMG) operated for NASA by the NWS at the Johnson Space Center (JSC) in Houston, TX, and the NWS forecast office in Melbourne, FL (MLB). The gap between research and operations is well known. All too frequently, the process of transitioning research to operations fails for various reasons. The mission of the AMU is in essence to bridge this gap for America's space program.

  17. Research priorities for specialized nursing practice in the United Arab Emirates.

    Al-Yateem, N; Al-Tamimi, M; Brenner, M; Altawil, H; Ahmad, A; Brownie, S

    2017-08-25

    Globally, nurses are undertaking expanded and more specialized roles in healthcare planning and service delivery in response to changing patterns and levels of health service demand. This means the nursing profession is increasingly considered as leaders in health service policy, research and practice. The United Arab Emirates has strengthened nursing governance and practice by establishing a Nursing and Midwifery Council and increasing the activity of nursing specialization, service leadership and research. This study aimed to identify clinically relevant research priorities to facilitate nursing contributions to evidence-based care and strengthening health services in the country. A two-stage Delphi study design was used. The first round involved 783 participants. The second round involved 1116 participants, as more clinical settings were accessed. In total, 58 research priorities across a variety of nursing specialties (paediatrics, emergency care, intensive care, labour and maternity care, operating theatre and long-term care) were identified as highly important. These identified priorities will guide a more informed programme of research in each nursing specialty, with the aim of strengthening the evidence base to improving outcomes for patients and their families in the United Arab Emirates. The findings provide guidance on key areas for nurses to focus research contributions to enhance evidence-based care and strengthen health systems. The identified priorities may also guide researchers in academic institutions to conduct research informed by current, clinically relevant issues. The findings may help inform funders and policymakers to support allocation of funding to research that has potential to contribute to enhancing nursing care in specialist areas. © 2017 International Council of Nurses.

  18. Re-visioning the doctoral research degree in nursing in the United Kingdom.

    Burton, Christopher R; Duxbury, Joy; French, Beverley; Monks, Rob; Carter, Bernie

    2009-05-01

    In the light of concerns about the wider social and economic value of the PhD training programme, this article discusses the challenges being directed primarily at the traditional doctoral programme of study. While the PhD is primarily concerned with the student making an original contribution to knowledge, the value-added component of the doctoral research degree needs to respond to the needs of a wider market of purchasers, and to meet practice and policy requirements for research leadership. The United Kingdom Research Councils (UK GRAD, 2001. Joint Skills Statement of Skills Training Requirements. Available at http://www.grad.ac.uk/downloads/documents/general/Joint%20Skills%20Statementpdf. (last accessed 1st April 2008.) suggest a range of seven skill domains over and above research design and management that should be offered to students. The seven domains are research skills and techniques, participation in the research environment, research management, personal effectiveness, communication, networking and team working, and career management. This article develops and extends these skill domains for the current healthcare context and considers how these should guide the development and evaluation of the value-added components of doctoral research degree programmes in nursing. The challenges that these issues present to academic departments are also discussed. Our conclusion is that PhD research training needs re-visioning and broadening so that the students' experience includes these value-added components.

  19. [Research advance in nitrogen metabolism of plant and its environmental regulation].

    Xu, Zhenzhu; Zhou, Guangsheng

    2004-03-01

    Nitrogen metabolism is not only one of the basic processes of plant physiology, but also one of the important parts of global chemical cycle. Plant nitrogen assimilation directly takes part in the synthesis and conversion of amino acid through the reduction of nitrate. During this stage, some key enzymes, e.g., nitrate reductase (NR), glutamine synthetase (GS), glutamate dehydrogenase (GDH), glutamine synthase (GOGAT), aspargine synthetase (AS), and asparate aminotransferase (AspAT) participate these processes. The protein is assimilated in plant cell through amino acid, and becomes a part of plant organism through modifying, classifying, transporting and storing processes, etc. The nitrogen metabolism is associated with carbonic metabolism through key enzyme regulations and the conversion of products, which consists of basic life process. Among these amino acids in plant cell, glutamic acid (Glu), glutamine (Gln), aspartic acid (Asp) and asparagines (Asn), etc., play a key role, which regulates their conversion each other and their contents in the plant cell through regulating formation and activity of those key enzymes. Environmental factors also affect the conversion and recycle of the key amino acids through regulating gene expression of the key enzymes and their activities. Nitrate and light intensity positively regulate the gene transcription of NR, but ammonium ions and Glu, Gln do the negative way. Water deficit is a very serious constraint on N2 fixation rate and soybean (Glycine max Merr.) grain yield, in which, ureide accumulation and degradation under water deficit appear to be the key issues of feedback mechanism on nitrogen fixation. Water stress decreases NR activity, but increases proteinase activity, and thus, they regulate plant nitrogen metabolism, although there are some different effects among species and cultivars. Water stress also decreases plant tissue protein content, ratio of protein and amino acid, and reduces the absorption of amino

  20. Meeting a Binational Research Challenge: Substance Abuse Among Transnational Mexican Farmworkers in the United States

    Garcia, Victor

    2011-01-01

    To help in understanding the manner in which community, individual, and other factors in the United States and Mexico contribute to drug use among transnational migrants, this paper introduces a binational social ecology model of substance abuse in this population. We draw on our 2 NIH-funded ethnographic studies—1 on problem drinking and the other on drug abuse—among transnational Mexican workers in the mushroom industry of southeastern Pennsylvania. Our model demonstrates that major reasons for substance abuse among transnational migrants include nontraditional living arrangements in labor camps and overcrowded apartments, the absence of kin and community deterrents to drug use, social isolation, the presence of drug use and binge drinking subcultures, the availability of drugs, family history of drugs, previous drug use or witnessing of drug use in Mexico, and drug use norms and drug availability in Mexico. It suggests the need for US and Mexican researchers to collaborate in binational teams and address factors on both sides of the border. Our binational social ecology model, together with our research recommendations, will assist alcohol and drug researchers to discover how community and individual factors in both the United States and abroad fit and interact beyond mere association and provide a more comprehensive research approach to substance abuse research among transnational migrants. PMID:18237326

  1. Characteristics and lessons learned from practice-based research networks (PBRNs in the United States

    Keller S

    2012-09-01

    Full Text Available Melinda M Davis,1,2 Sara Keller,1 Jennifer E DeVoe,1,3 Deborah J Cohen11Department of Family Medicine, 2Oregon Rural Practice-based Research Network, Oregon Health & Science University, Portland, OR, USA; 3OCHIN Practice-based Research Network, Portland, OR, USAAbstract: Practice-based research networks (PBRNs are organizations that involve practicing clinicians in asking and answering clinically relevant research questions. This review explores the origins, characteristics, funding, and lessons learned through practice-based research in the United States. Primary care PBRNs emerged in the USA in the 1970s. Early studies explored the etiology of common problems encountered in primary care practices (eg, headache, miscarriage, demonstrating the gap between research conducted in controlled specialty settings and real-world practices. Over time, national initiatives and an evolving funding climate have shaped PBRN development, contributing to larger networks, a push for shared electronic health records, and the use of a broad range of research methodologies (eg, observational studies, pragmatic randomized controlled trials, continuous quality improvement, participatory methods. Today, there are over 160 active networks registered with the Agency for Healthcare Research and Quality's PBRN Resource Center that engage primary care clinicians, pharmacists, dentists, and other health care professionals in research and quality-improvement initiatives. PBRNs provide an important laboratory for encouraging collaborative research partnerships between academicians and practices or communities to improve population health, conduct comparative effectiveness and patient-centered outcomes research, and study health policy reform. PBRNs continue to face critical challenges that include: (1 adapting to a changing landscape; (2 recruiting and retaining membership; (3 securing infrastructure support; (4 straddling two worlds (academia and community and managing

  2. The Best Practice Unit: a model for learning, research and development

    Jean Pierre Wilken

    2013-06-01

    Full Text Available The Best Practice Unit: a model for learning, research and development The Best Practice Unit (BPU model constitutes a unique form of practice-based research. A variant of the Community of Practice model developed by Wenger, McDermott and Snyder (2002, the BPU has the specific aim of improving professional practice by combining innovation and research. The model is used as a way of working by a group of professionals, researchers and other relevant individuals, who over a period of one to two years, work together towards a desired improvement. The model is characterized by interaction between individual and collective learning processes, the development of new or improved working methods, and the implementation of these methods in daily practice. Multiple knowledge resources are used, including experiential knowledge, professional knowledge and scientific knowledge. The research serves diverse purposes: articulating tacit knowledge, documenting learning and innovation processes, systematically describing the working methods that have been revealed or developed, and evaluating the efficacy of the new methods. Each BPU is supported by a facilitator, whose main task is to optimize learning processes. An analysis of ten different BPUs in different professional fields shows that this is a successful model. The article describes the methodology and results of this study. De Best Practice Unit: een model voor leren, onderzoek en ontwikkeling Het model van de Best Practice Unit (BPU is een unieke vorm van praktijkgericht onderzoek. De Best Practice Unit is een variant van de Community of Practice zoals ontwikkeld door Wenger, McDermott en Snyder (2002 met als specifiek doel om de professionele praktijk te verbeteren door innovatie en onderzoek te combineren. Het model wordt gebruikt om in een periode van 1-2 jaar met een groep professionals, onderzoekers en andere betrokkenen te werken aan een gewenste verbetering. Kenmerkend is de wisselwerking tussen

  3. What should autism research focus upon? Community views and priorities from the United Kingdom

    Dinsmore, Adam; Charman, Tony

    2014-01-01

    The rise in the measured prevalence of autism has been accompanied by much new research and research investment internationally. This study sought to establish whether the pattern of current UK autism research funding maps on to the concerns of the autism community. Interviews and focus groups were conducted with autistic adults, family members, practitioners and researchers to identify their priorities for research. We also captured the views of a large number of stakeholders via an online survey. There was a clear disparity between the United Kingdom’s pattern of funding for autism research and the priorities articulated by the majority of participants. There was general consensus that future priorities for autism research should lie in those areas that make a difference to people’s day-to-day lives. There needs to be greater involvement of the autism community both in priority setting and in research more broadly to ensure that resources reach where they are most needed and can make the most impact. PMID:24789871

  4. Research nurses in New Zealand intensive care units: A qualitative descriptive study.

    Mackle, Diane; Nelson, Katherine

    2018-04-20

    This study explored the role of the research nurse in New Zealand (NZ) Level III intensive care units (ICU). Little was known about this role in NZ prior to this study. To describe the role and responsibilities of NZ ICU research nurses. A qualitative, descriptive approach, using semi structured interviews was used. The study was conducted in six Level III ICUs throughout NZ that employed a research nurse. Interviews were conducted with research nurses (n = 11), principal investigators (n = 6) and nurse managers (n = 6), and the findings were triangulated. The views across all ICUs and stakeholders were generally similar, with differences only being in some operational areas. This study found that the primary role of the research nurse was trial management, where they coordinated all elements of trial conduct. Almost half of the research nurses were involved in trial design through their positions on management committees. Research nurses also played a vital role in patient and trial advocacy, and they bridged the knowledge gap by bringing research to staff nurses, patients and their families. The majority of research nurses reported to a nursing line manager, and had an informal accountability to the PI. The role of NZ ICU research nurses is similar to their international counterparts. This study provides clarity about the research nurse role and showcases their key contribution in ensuring that NZ ICUs undertake high quality research, thus contributing to potential improvements for future patients' outcomes. Copyright © 2018 Australian College of Critical Care Nurses Ltd. Published by Elsevier Ltd. All rights reserved.

  5. Urine metabolic profiling for the pathogenesis research of erosive oral lichen planus.

    Li, Xu-Zhao; Yang, Xu-Yan; Wang, Yu; Zhang, Shuai-Nan; Zou, Wei; Wang, Yan; Li, Xiao-Nan; Wang, Ling-Shu; Zhang, Zhi-Gang; Xie, Liang-Zhen

    2017-01-01

    Oral lichen planus (OLP) is a relatively common chronic immune-pathological and inflammatory disease and potentially oral precancerous lesion. Erosive OLP patients show the higher rate of malignant transformation than patients with non-erosive OLP. Identifying the potential biomarkers related to erosive OLP may help to understand the pathogenesis of the diseases. Metabolic profiles were compared in control and patient subjects with erosive OLP by using ultra-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF-MS) coupled with pattern recognition methods An integrative analysis was used to identify the perturbed metabolic pathways and pathological processes that may be associated with the disease. In total, 12 modulated metabolites were identified and considered as the potential biomarkers of erosive OLP. Multiple metabolic pathways and pathological processes were involved in erosive OLP. The dysregulations of these metabolites could be used to explain the pathogenesis of the disease, which could also be the potential therapeutic targets for the disease. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Overall Assessment of Human Research and Ethics Committees in the United Arab Emirates.

    Abdulrahman, Mahera; Nair, Satish Chandrasekhar

    2017-04-01

    Growing demand for human health research in the United Arab Emirates (UAE) has prompted the need to develop a robust research ethics oversight. Examination of the structure, function, and practices of the human research ethics committees (HRECs), followed by evaluation of standards for measuring research output, was conducted. Results indicate that among the HRECs, 90% followed International Council for Harmonization-Good Clinical Practice guidelines, 66.6% have been in operation for more than 5 years, 95% reviewed proposals within 8 weeks, and 56% reviewed for scientific merit apart from ethics. However, systems to recognize accomplishments of researchers, funding transparency, and adverse event reporting were deployed in less than 30% of all HRECs. Research was incorporated into the vision and mission statements of many (65%) organizations. Research publications, collaborations, and recognitions were used to measure research output and report key performance indicators. In spite, resources to generate research output such as dedicated budget (20%), support staff (20%), and continuous training and mentoring program for medical residents (15%) and HREC members (25%) were somehow lacking. HREC structure and operations in the UAE are similar to other regions of the world. Systems to conduct research and report outcomes are defined in the UAE. Regulatory legislation and allocation of resources to support the clinical research enterprise will not only help to meet growing demand for clinical trials but also transform the quality of patient care in the UAE. It is anticipated that the results of this study will benefit investigators, regulators, pharmaceutical sponsors, and the policy makers in the region.

  7. Progress in human embryonic stem cell research in the United States between 2001 and 2010.

    Keyvan Vakili

    Full Text Available On August 9th, 2001, the federal government of the United States announced a policy restricting federal funds available for research on human embryonic stem cell (hESCs out of concern for the "vast ethical mine fields" associated with the creation of embryos for research purposes. Until the policy was repealed on March 9th, 2009, no U.S. federal funds were available for research on hESCs extracted after August 9, 2001, and only limited federal funds were available for research on a subset of hESC lines that had previously been extracted. This paper analyzes how the 2001 U.S. federal funding restrictions influenced the quantity and geography of peer-reviewed journal publications on hESC. The primary finding is that the 2001 policy did not have a significant aggregate effect on hESC research in the U.S. After a brief lag in early 2000s, U.S. hESC research maintained pace with other areas of stem cell and genetic research. The policy had several other consequences. First, it was tied to increased hESC research funding within the U.S. at the state level, leading to concentration of related activities in a relatively small number of states. Second, it stimulated increased collaborative research between US-based scientists and those in countries with flexible policies toward hESC research (including Canada, the U.K., Israel, China, Spain, and South Korea. Third, it encouraged independent hESC research in countries without restrictions.

  8. FFUSION yearbook 1995. Annual report of the Finnish research unit. Association EURATOM-TEKES

    Karttunen, S; Paettikangas, T [eds.; VTT Energy, Espoo (Finland)

    1996-03-01

    Finnish Fusion Research Programme (FFUSION) is one of the eleven national energy research programmes funded by the Technological Development Centre of Finland (TEKES). All fusion related research in Finland is included in the FFUSION programme and it made it possible to establish a dialogue with the European Fusion Programme already two years before Finland joined the European Union. The process led to the founding of the Association Euratom-TEKES in early 1995. The contract of Association was signed in Helsinki on March 13 1995, to establish the 14th Association in the EU FFusion Programme. This annual report summarises the research activities of the Finnish Research Unit in 1995. The emphasis is on research supported by the EU Commission. The programme consists of two parts: Physics and Technology. The research areas of the physics are: Fusion plasma engineering, Radio-frequency heating and plasma diagnostics, and Plasma-wall interactions - ion-beam studies of the reactor materials. The technology is focused into three areas: Fusion reactor materials (first wall components and joining techniques), and Remote handling

  9. Current nondestructive evaluation research and development trends in the United States

    Jackson, Jerry

    1992-01-01

    An underlying theme present in much of the nondestructive evaluation (NDE) research and development occurring in the United States as well as worldwide is the application of physics and engineering principles toward understanding and optimizing NDE processes. Expanding this trend of using mathematical models for NDE processes is critical to the entire spectrum of NDE technology. In NDE research, modeling anchors the investigation in scientific, proven principles and establishes a firm technical basis to guide the design and development of inspection equipment and approaches. It also provides for understanding the capabilities and the limitations of whatever designs are selected and ultimately applied in the field. This paper reviews the status of these efforts, presents several examples where mathematical modeling is being profitably used for practical inspection work, and shows the path being taken in ongoing research.

  10. Application of the partitive analytical forecasting (PAF) technique to the United States controlled thermonuclear research effort

    Nichols, S.P.

    1975-01-01

    The Partitive Analytical Forecasting (PAF) technique is applied to the overall long-term program plans for the Division of Controlled Thermonuclear Research (DCTR) of the United States Energy Research and Development Administration (ERDA). As part of the PAF technique, the Graphical Evaluation and Review Technique (GERTS) IIIZ computer code is used to perform simulations on a logic network describing the DCTR long-term program plan. Logic networks describing the tokamak, mirror, and theta-pinch developments are simulated individually and then together to form an overall DCTR program network. The results of the simulation of the overall network using various funding schemes and strategies are presented. An economic sensitivity analysis is provided for the tokamak logic networks. An analysis is also performed of the fusion-fission hybrid concept in the context of the present DCTR goals. The results mentioned above as well as the PAF technique itself are evaluated, and recommendations for further research are discussed

  11. Testing of the Advanced Stirling Radioisotope Generator Engineering Unit at NASA Glenn Research Center

    Lewandowski, Edward J.

    2013-01-01

    The Advanced Stirling Radioisotope Generator (ASRG) is a high-efficiency generator being developed for potential use on a Discovery 12 space mission. Lockheed Martin designed and fabricated the ASRG Engineering Unit (EU) under contract to the Department of Energy. This unit was delivered to NASA Glenn Research Center in 2008 and has been undergoing extended operation testing to generate long-term performance data for an integrated system. It has also been used for tests to characterize generator operation while varying control parameters and system inputs, both when controlled with an alternating current (AC) bus and with a digital controller. The ASRG EU currently has over 27,000 hours of operation. This paper summarizes all of the tests that have been conducted on the ASRG EU over the past 3 years and provides an overview of the test results and what was learned.

  12. Research ethics committees in the regulation of clinical research: comparison of Finland to England, Canada, and the United States.

    Hemminki, Elina

    2016-01-19

    The aim of this paper is to compare common features and variation in the work of research ethics committees (RECs) in Finland to three other countries - England, Canada, the United States of America (USA) - in the late 2000s. Several approaches and data sources were used, including semi- or unstructured interviews of experts, documents, previous reports, presentations in meetings and observations. A theoretical framework was created and data from various sources synthesized. In Finland, RECs were regulated by a medical research law, whereas in the other countries many related laws and rules guided RECs; drug trials had specific additional rules. In England and the USA, there was a REC control body. In all countries, members were voluntary and included lay-persons, and payment arrangements varied. Patient protection was the main ethics criteria, but other criteria (research advancement, availability of results, payments, detailed fulfilment of legislation) varied. In all countries, RECs had been given administrative duties. Variations by country included the mandate, practical arrangements, handling of multi-site research, explicitness of proportionate handlings, judging scientific quality, time-limits for decisions, following of projects, role in institute protection, handling conflicts of interests, handling of projects without informed consent, and quality assurance research. The division of work between REC members and secretariats varied in checking of formalities. In England, quality assurance of REC work was thorough, fairly thorough in the USA, and not performed in Finland. The work of RECs in the four countries varied notably. Various deficiencies in the system require action, for which international comparison can provide useful insights.

  13. Qualitative research within trials: developing a standard operating procedure for a clinical trials unit

    2013-01-01

    Background Qualitative research methods are increasingly used within clinical trials to address broader research questions than can be addressed by quantitative methods alone. These methods enable health professionals, service users, and other stakeholders to contribute their views and experiences to evaluation of healthcare treatments, interventions, or policies, and influence the design of trials. Qualitative data often contribute information that is better able to reform policy or influence design. Methods Health services researchers, including trialists, clinicians, and qualitative researchers, worked collaboratively to develop a comprehensive portfolio of standard operating procedures (SOPs) for the West Wales Organisation for Rigorous Trials in Health (WWORTH), a clinical trials unit (CTU) at Swansea University, which has recently achieved registration with the UK Clinical Research Collaboration (UKCRC). Although the UKCRC requires a total of 25 SOPs from registered CTUs, WWORTH chose to add an additional qualitative-methods SOP (QM-SOP). Results The qualitative methods SOP (QM-SOP) defines good practice in designing and implementing qualitative components of trials, while allowing flexibility of approach and method. Its basic principles are that: qualitative researchers should be contributors from the start of trials with qualitative potential; the qualitative component should have clear aims; and the main study publication should report on the qualitative component. Conclusions We recommend that CTUs consider developing a QM-SOP to enhance the conduct of quantitative trials by adding qualitative data and analysis. We judge that this improves the value of quantitative trials, and contributes to the future development of multi-method trials. PMID:23433341

  14. National funding for mental health research in Finland, France, Spain and the United Kingdom.

    Hazo, Jean-Baptiste; Gandré, Coralie; Leboyer, Marion; Obradors-Tarragó, Carla; Belli, Stefano; McDaid, David; Park, A-La; Maliandi, Maria Victoria; Wahlbeck, Kristian; Wykes, Til; van Os, Jim; Haro, Josep Maria; Chevreul, Karine

    2017-09-01

    As part of the Roamer project, we aimed at revealing the share of health research budgets dedicated to mental health, as well as on the amounts allocated to such research for four European countries. Finland, France, Spain and the United Kingdom national public and non-profit funding allocated to mental health research in 2011 were investigated using, when possible, bottom-up approaches. Specifics of the data collection varied from country to country. The total amount of public and private not for profit mental health research funding for Finland, France, Spain and the UK was €10·2, €84·8, €16·8, and €127·6 million, respectively. Charities accounted for a quarter of the funding in the UK and less than six per cent elsewhere. The share of health research dedicated to mental health ranged from 4·0% in the UK to 9·7% in Finland. When compared to the DALY attributable to mental disorders, Spain, France, Finland, and the UK invested respectively €12·5, €31·2, €39·5, and €48·7 per DALY. Among these European countries, there is an important gap between the level of mental health research funding and the economic and epidemiologic burden of mental disorders. Copyright © 2017 Elsevier B.V. and ECNP. All rights reserved.

  15. Progress of the United States foreign research reactor spent nuclear fuel acceptance program

    Huizenga, D.G.; Clapper, M.; Thrower, A.W.

    2002-01-01

    The United States Department of Energy (DOE), in consultation with the Department of State (DOS), adopted the Nuclear Weapons Nonproliferation Policy Concerning Foreign Research Reactor Spent Nuclear Fuel in May 1996. To date, the Foreign Research Reactor (FRR) Spent Nuclear Fuel (SNF) Acceptance Program has completed 23 shipments. Almost 5000 spent fuel assemblies from eligible research reactors throughout the world have been accepted into the United States under this program. Over the past year, another cross-country shipment of fuel was accomplished, as well as two additional shipments in the fourth quarter of calendar year 2001. These shipments attracted considerable safeguards oversight since they occurred post September 11. Recent guidance from the Nuclear Regulatory Commission (NRC) pertaining to security and safeguards issues deals directly with the transport of nuclear material. Since the Acceptance Program has consistently applied above regulatory safety enhancements in transport of spent nuclear fuel, this guidance did not adversely effect the Program. As the Program draws closer to its termination date, an increased number of requests for program extension are received. Currently, there are no plans to extend the policy beyond its current expiration date; therefore, eligible reactor operators interested in participating in this program are strongly encouraged to evaluate their inventory and plan for future shipments as soon as possible. (author)

  16. The unit cost factors and calculation methods for decommissioning - Cost estimation of nuclear research facilities

    Kwan-Seong Jeong; Dong-Gyu Lee; Chong-Hun Jung; Kune-Woo Lee

    2007-01-01

    Available in abstract form only. Full text of publication follows: The uncertainties of decommissioning costs increase high due to several conditions. Decommissioning cost estimation depends on the complexity of nuclear installations, its site-specific physical and radiological inventories. Therefore, the decommissioning costs of nuclear research facilities must be estimated in accordance with the detailed sub-tasks and resources by the tasks of decommissioning activities. By selecting the classified activities and resources, costs are calculated by the items and then the total costs of all decommissioning activities are reshuffled to match with its usage and objectives. And the decommissioning cost of nuclear research facilities is calculated by applying a unit cost factor method on which classification of decommissioning works fitted with the features and specifications of decommissioning objects and establishment of composition factors are based. Decommissioning costs of nuclear research facilities are composed of labor cost, equipment and materials cost. Of these three categorical costs, the calculation of labor costs are very important because decommissioning activities mainly depend on labor force. Labor costs in decommissioning activities are calculated on the basis of working time consumed in decommissioning objects and works. The working times are figured out of unit cost factors and work difficulty factors. Finally, labor costs are figured out by using these factors as parameters of calculation. The accuracy of decommissioning cost estimation results is much higher compared to the real decommissioning works. (authors)

  17. The characteristics analysis of torque and rotation speed of working unit of branch grinder - introductory research

    Warguła Łukasz

    2018-01-01

    Full Text Available Carrying out a realistic research on working units of machines that grinder waste coming from tree and bush trimming requires designing machines that would be more efficient. It is neccesary both to introduce the analysis of already existing solutions as well as searching for innovative ones that would result in the increase of efficiency, lowering the costs and time needed as well as lower exhaust emission into the atmosphere. The results presented below will be used for the following purposes: the analysis of grinding process that supplies data to cunstruct simulating models that reflect the real working conditions of grinding machines. The results of the experiments will allow to estimate the influence of construction featrures, including the ones connected with automatisation. The importance of the carried out research is also applicable to the analisys of influence of grinding process on the form of flakes that result from the process, energy consumption. It also allows to make conclusions leading to the improvement of the processes that use grinded mass.The construction specifity of ths kind of machines and their working principles results from the fact, that the cutting process they perform concerns orthotropic plant material that has inhomogenic structure and physical-chemical properties requires further analysis. The article presents the construcion of a research stand designed to record the characteristisc of changes of the torque and rotation speed of working unit of mill chopper type MQS2800 Macalister. The introductory research results presented below point out that depending on the position of the sample (along the grain against the mill chopper significantly influences on the form of generated changes of the torque. The research stand that has been designed and constructed allows the analysis of both construction features of the chopper as well via the assessment of grinding process also separte paremeters of processed wood.

  18. Mass spectrometry-based metabolomics: applications to biomarker and metabolic pathway research.

    Zhang, Aihua; Sun, Hui; Yan, Guangli; Wang, Ping; Wang, Xijun

    2016-01-01

    Mass spectrometry-based metabolomics has become increasingly popular in molecular medicine. High-definition mass spectrometry (MS), coupled with pattern recognition methods, have been carried out to obtain comprehensive metabolite profiling and metabolic pathway of large biological datasets. This sets the scene for a new and powerful diagnostic approach. Analysis of the key metabolites in body fluids has become an important part of improving disease diagnosis. With technological advances in analytical techniques, the ability to measure low-molecular-weight metabolites in bio-samples provides a powerful platform for identifying metabolites that are uniquely correlated with a specific human disease. MS-based metabolomics can lead to enhanced understanding of disease mechanisms and to new diagnostic markers and has a strong potential to contribute to improving early diagnosis of diseases. This review will highlight the importance and benefit with certain characteristic examples of MS-metabolomics for identifying metabolic pathways and metabolites that accurately screen for potential diagnostic biomarkers of diseases. Copyright © 2015 John Wiley & Sons, Ltd.

  19. Accounting for Diversity in Suicide Research: Sampling and Sample Reporting Practices in the United States.

    Cha, Christine B; Tezanos, Katherine M; Peros, Olivia M; Ng, Mei Yi; Ribeiro, Jessica D; Nock, Matthew K; Franklin, Joseph C

    2018-04-01

    Research on suicidal thoughts and behaviors (STB) has identified many risk factors, but whether these findings generalize to diverse populations remains unclear. We review longitudinal studies on STB risk factors over the past 50 years in the United States and evaluate the methodological practices of sampling and reporting sample characteristics. We found that articles frequently reported participant age and sex, less frequently reported participant race and ethnicity, and rarely reported participant veteran status or lesbian, gay, bisexual, and transgender status. Sample reporting practices modestly and inconsistently improved over time. Finally, articles predominantly featured White, non-Hispanic, young adult samples. © 2017 The American Association of Suicidology.

  20. Scoping Study on Research and Development Priorities for Distribution-System Phasor Measurement Units

    Eto, Joseph H. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Stewart, Emma M. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Smith, Travis [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Buckner, Mark [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Kirkham, Harold [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Tuffner, Francis [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Schoenwald, David A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-04-01

    This report addresses the potential use of phasor measurement units (PMUs) within electricity distribution systems, and was written to assess whether or not PMUs could provide significant benefit, at the national level. We analyze examples of present and emerging distribution-system issues related to reliability, integration of distributed energy resources, and the changing electrical characteristics of load. We find that PMUs offer important and irreplaceable advantages over present approaches. However, we also find that additional research and development for standards, testing and calibration, demonstration projects, and information sharing is needed to help industry capture these benefits.

  1. Research and development activities on Three Mile Island Unit Two. Annual report for 1985

    1986-04-01

    The year 1985 was significant in the cleanup of Three Mile Island Unit 2 (TMI-2). Major milestones in the project included lifting the plenum assembly from the reactor vessel and the start of operations to remove the damaged fuel from the reactor. This report summarizes these milestones and other TMI-2 related cleanup, research, and development activities. Other major topics include the following: waste immobilization and management; fuel shipping cask delivery and testing; sample acquisition and evaluation; and decontamination and dose reduction. 26 figs.

  2. Energy research and development in the United Kingdom: a discussion document. [Monograph

    1976-01-01

    This paper provides a framework for the future planning of United Kingdom research and development in energy technologies. It contains the first steps in the formulation of a national energy R and D strategy. Decision on energy R and D must be taken in the light of the overall aims of energy policies. The main objectives of energy policy are to meet the energy needs of the country at minimum cost in real resources over time, while paying due regard to security of supply, to public safety, to protection of the environment and, where major change is in prospect, to the social consequences of change.

  3. Research on collaborative innovation mechanism of green construction supply chain based on united agency

    Zhang, Min; He, Weiyi

    2018-06-01

    Under the guidance of principal-agent theory and modular theory, the collaborative innovation of green technology-based companies, design contractors and project builders based on united agency will provide direction for the development of green construction supply chain in the future. After analyzing the existing independent agencies, this paper proposes the industry-university-research bilateral collaborative innovation network architecture and modularization with the innovative function of engineering design in the context of non-standard transformation interfaces, analyzes the innovation responsibility center, and gives some countermeasures and suggestions to promote the performance of bilateral cooperative innovation network.

  4. Recruiting bereaved parents for research after infant death in the neonatal intensive care unit.

    Currie, Erin R; Roche, Cathy; Christian, Becky J; Bakitas, Marie; Meneses, Karen

    2016-11-01

    Understanding parental experiences following infant death in the neonatal intensive care unit (NICU) is a high research priority and a necessary first step to improving health services. However, recruiting bereaved parents to discuss their experiences on such an extremely sensitive topic can be challenging and research procedures must be planned carefully in order to get an adequate sample. There is little published in the literature detailing specific strategies for recruiting bereaved parents for grief research, especially strategies for contacting parents and identifying factors that might affect participation. The purpose of this paper is to describe the process of recruiting bereaved parents into a qualitative research study exploring parental NICU experiences and grief responses following infant death. We describe a successful recruitment plan that led to the enrollment of difficult to recruit participants such as fathers, and individuals representing minorities and those from lower socioeconomic (SES) groups. Bereaved parents of infants after an NICU hospitalization should continue to be recruited for research studies for their unique perspectives and valuable insights about the devastating experience of infant death. Participants in this study reported more benefits than harm and the results addressed a critical gap in the literature. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. Pharmacoeconomics and outcomes research degree-granting PhD programs in the United States.

    Slejko, Julia F; Libby, Anne M; Nair, Kavita V; Valuck, Robert J; Campbell, Jonathan D

    2013-01-01

    Evidence is missing on showcasing current practices of degree programs specific to the field of pharmaceutical outcomes research. To measure current practices of pharmacoeconomics and outcomes research PhD programs in the United States and synthesize recommendations for improving the success of programs and prospective students. A 23-question online survey instrument was created and distributed to 32 program directors identified in the International Society for Pharmacoeconomics and Outcomes Research educational directory. Descriptive statistics summarized both the program characteristics (including observed and desired number of faculty and students) and training recommendations (traits of program and student success). Of 30 eligible programs that conferred a PhD in pharmacoeconomics, pharmaceutical outcomes research, or a related field, 16 respondents (53%) completed the survey. Seventy-five percent of respondents were located in a school of pharmacy. The average observed number of faculty (7.5) and students (11.5) was lower than the average desired numbers (8.1) and (14.7), respectively. Reputation of faculty research and a collaborative environment with other disciplines were rated highest for a program's success. Faculty's mentoring experience and reputation and student funding opportunities were rated highest for prospective students' success. Existing and emerging programs as well as prospective students can use these findings to further their chances of success. Copyright © 2013 Elsevier Inc. All rights reserved.

  6. EVALUATION OF THE LEARNING SYSTEM BASED ON RESEARCH (SABI IN THE CICS UMA IPN BIOCHEMISTRY UNIT

    Blanca Elisa Pérez-Magaña

    2014-07-01

    Full Text Available Learning is a steward, permanent, and participatory process where: the apprentice, teacher, classmates, institution and other social factors where the student performs. As detonator of learning is research, which is made from real events that are addressed on the basis of the scientific development of the State of the art. One of the key elements in the professional training of students is the method that is used. Research-based learning system is an educational innovation (SABI, which was used in the learning of basic sciences of the Cardiovascular apparatus in generations unit 33rd, 34th, 35th, 36th and 37th generations in the years of 2008 to 2012's career in medicine and as a result was a decrease in the number of students reproachedimproving achievement. This method is an excellent alternative in the teaching-learning process and can be used both in groups with a variable number of students.

  7. Foreign research reactor irradiated nuclear fuel inventories containing HEU and LEU of United States origin

    Matos, J.E.

    1994-12-01

    This report provides estimates of foreign research reactor inventories of aluminum-based and TRIGA irradiated nuclear fuel elements containing highly enriched and low enriched uranium of United States origin that are anticipated in January 1996, January 2001, and January 2006. These fuels from 104 research reactors in 41 countries are the same aluminum-based and TRIGA fuels that were eligible for receipt under the Department of Energy's Offsite Fuels Policy that was in effect in 1988. All fuel inventory and reactor data that were available as of December 1, 1994, have been included in the estimates of approximately 14,300 irradiated fuel elements in January 1996, 18,800 in January 2001, and 22,700 in January 2006

  8. Overview of feedstock research in the United States, Canada, and Brazil

    Ferrell, J. [Department of Energy, Washington, DC (United States); Tardif, M.L. [CANMET, Ottawa, Ontario (Canada); Couto, L. [Universidade Federal de Vicosa (Brazil); Garca, L.R. [Centro Nacional de Pesquisa de Florestas, Colombo (Brazil); Betters, D. [Colorado State Univ., Fort Collins, CO (United States); Ashworth, J. [Meridian Corp., Alexandria, VA (United States)

    1993-12-31

    This is an overview of the current biomass feedstock efforts in Brazil, Canada, and the United States. The report from Brazil provides an historical perspective of incentive programs, the charcoal and fuelwood energy programs, the alcohol program, and other biomass energy efforts. The efforts in Brazil, particularly with the sugar cane to ethanol and the charcoal and fuelwood programs, dwarfs other commercial biomass systems in the Americas. One of the bright spots in the future is the Biomass Integrated Gasification/Gas Turbine Electricity Project initially funded in 1992. The sugar cane-based ethanol industry continues to develop higher yielding cane varieties and more efficient microorganisms to convert the sugar cane carbohydrates into alcohol. In Canada a number of important institutions and enterprises taking part in the economical development of the country are involved in biomass research and development including various aspects of the biomass such as forestry, agricultural, industrial, urban, food processing, fisheries and peat bogs. Biomass feedstock research in the United States is evolving to reflect Department of Energy priorities. Greater emphasis is placed on leveraging research with the private sector contributing a greater share of funds, for both research and demonstration projects. The feedstock program, managed by ORNL, is focused on limited model species centered at a regional level using a multidisciplinary approach. Activities include a stronger emphasis on emerging environmental issues such as biodiversity, sustainability and habitat management. DOE also is a supporter of the National Biofuels Roundtable, which is developing principles for producing biomass energy in an economically viable and ecologically sound manner. Geographical Information Systems are also being developed as tools to quantify and characterize the potential supply of energy crops in various regions.

  9. Status Report and Research Plan for Cables Harvested from Crystal River Unit 3 Nuclear Generating Plant

    Fifield, Leonard S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-09-20

    Harvested cables from operating or decommissioned nuclear power plants present an important opportunity to validate models, understanding material aging behavior, and validate characterization techniques. Crystal River Unit 3 Nuclear Generating Plant is a pressurized water reactor that was licensed to operate from 1976 to 2013. Cable segments were harvested and made available to the Light Water Reactor Sustainability research program through the Electric Power Research Institute. Information on the locations and circuits within the reactor from whence the cable segments came, cable construction, sourcing and installation information, and photographs of the cable locations prior to harvesting were provided. The cable variations provided represent six of the ten most common cable insulations in the nuclear industry and experienced service usage for periods from 15 to 42 years. Subsequently, these cables constitute a valuable asset for research to understand aging behavior and measurement of nuclear cables. Received cables harvested from Crystal River Unit 3 Nuclear Generating Plant consist of low voltage, insulated conductor surrounded by jackets in lengths from 24 to 100 feet each. Cable materials will primarily be used to investigate aging under simultaneous thermal and gamma radiation exposure. Each cable insulation and jacket material will be characterized in its as-received condition, including determination of the temperatures associated with endothermic transitions in the material using differential scanning calorimetry and dynamic mechanical analysis. Temperatures for additional thermal exposure aging will be selected following the thermal analysis to avoid transitions in accelerated laboratory aging that do not occur in field conditions. Aging temperatures above thermal transitions may also be targeted to investigate the potential for artifacts in lifetime prediction from rapid accelerated aging. Total gamma doses and dose rates targeted for each material

  10. Cytosolic fatty acid-binding proteins: subjects and tools in metabolic research

    Binas, B. [Max Delbrueck Center for Molecular Medicine, Berlin-Buch (Germany)

    1998-12-31

    Fatty acid-binding proteins (FABPs) are major targets for specific binding of fatty acids in vivo. They constitute a widely expressed family of genetically related, small cytosolic proteins which very likely mediate intracellular transport of free long chain fatty acids. Genetic inhibition of FABP expression in vivo should therefore provide a useful tool to investigate and engineer fatty acid metabolism. (orig.) [Deutsch] Fettsaeurebindungsproteine (FABPs) sind wichtige Bindungsstellen fuer Fettsaeuren in vivo; sie bilden eine breit exprimierte Familie genetisch verwandter kleiner Zytosoleiweisse, die sehr wahrscheinlich den intrazellulaeren Transport unveresterter langkettiger Fettsaeuren vermitteln. Die genetische Hemmung der FABP-Expanssion in vivo bietet sich deshalb als Werkzeug zur Erforschung und gezielten Veraenderung des Fettsaeurestoffwechsels an. (orig.)

  11. The Status of Beryllium Research for Fusion in the United States

    Glen R. Longhurst

    2003-01-01

    Use of beryllium in fusion reactors has been considered for neutron multiplication in breeding blankets and as an oxygen getter for plasma-facing surfaces. Previous beryllium research for fusion in the United States included issues of interest to fission (swelling and changes in mechanical and thermal properties) as well as interactions with plasmas and hydrogen isotopes and methods of fabrication. When the United States formally withdrew its participation in the International Thermonuclear Experimental Reactor (ITER) program, much of this effort was terminated. The focus in the U.S. has been mainly on toxic effects of beryllium and on industrial hygiene and health-related issues. Work continued at the INEEL and elsewhere on beryllium-containing molten salts. This activity is part of the JUPITER II Agreement. Plasma spray of ITER first wall samples at Los Alamos National Laboratory has been performed under the European Fusion Development Agreement. Effects of irradiation on beryllium structure are being studied at Oak Ridge National Laboratory. Numerical and phenomenological models are being developed and applied to better understand important processes and to assist with design. Presently, studies are underway at the University of California Los Angeles to investigate thermo-mechanical characteristics of beryllium pebble beds, similar to research being carried out at Forschungszentrum Karlsruhe and elsewhere. Additional work, not funded by the fusion program, has dealt with issues of disposal, and recycling

  12. The status of beryllium research for fusion in the United States

    Longhurst, G.R.; Snead, L.L.; Abou-Sena, A.A.

    2004-01-01

    Use of beryllium in fusion reactor has been considered for neutron multiplication in breeding blankets an as an oxygen getter for plasma - facing surface. Previous beryllium research for fusion in the United States included issues of interest to fission (swelling an changes in mechanical and thermal properties) as well as interactions with plasmas and hydrogen isotopes and methods of fabrication. When the United States formally withdrew its participation in the International Experimental Reactor (ITER) program, much of this effort was terminated. The focus in the U.S. has been mainly on toxic effects of beryllium and on industrial hygiene and health-related issues. Work continued at the INEEL (Idaho National Engineering and Environmental Laboratory) and elsewhere on beryllium-containing molten salts. This activity is part of the JUPITER II Agreement. Plasma spray of ITER first wall samples at Los Alamos National Laboratory has been performed under the European Fusion Development Agreement. Effects of irradiation on beryllium structure are being studied at Oak Ridge National Laboratory. Numerical and phenomenological models are being developed and applied at the University of California Los Angels to investigate thermo-mechanical characteristics of beryllium pebble beds, similar to research being carried out at Forschungszentrum Karlsruhe and elsewhere. Additional work, not funded by the fusion program, has dealt with issues of disposal, and recycling. (author)

  13. Contraceptive choices among women attending the fertility research unit of Usmanu Danfodiyo University Teaching Hospital, Sokoto

    Constance E Shehu

    2013-01-01

    Full Text Available Background: One of the most sensitive and intimate decisions made by any individual or couple is that of fertility control . The knowledge of the factors which influence contraceptive choices may increase its acceptance and uptake. This study determines the choice and reason for contraception among new clients attending the Fertility Research Unit of Usmanu Danfodiyo University Teaching Hospital, Sokoto. Materials and Methods: In this prospective study a structured questionnaire was administered to 251 consecutive clients, who attended the Fertility Research Unit of Usmanu Danfodiyo University Teaching Hospital, Sokoto between 1 July 2008 and 31 December 2008. Results: Most (58.2% of the clients were between 21 and 30 years of age. Many (42.6% were grand multipara. Majority (76.9% of the clients were married. The main source of knowledge of contraception and referral (45.8% was the physicians. Child spacing (87.7% was the most common reason given for contraceptive use. Majority (55.8% of the clients chose Implanon and the least preferred method of contraception was the condom (2.0%. Conclusion: Our data shows that the most commonly chosen contraceptive method in the study population was the Implanon. Child spacing was the main reason for seeking family planning while the source of contraceptive knowledge was the physicians.

  14. Research on the Current Telecommuting Trends in United States and European Union Markets

    Catalina Georgiana PICU

    2016-12-01

    Full Text Available In the context of globalization and due to the accelerated progress made in information and communication technology, more and more companies offer their employees the option of telecommuting. For the past twenty years, telecommuting has been on an asceding trend, an incresing number of people embracing the ability to work from home, using a computer and internet connection to communicate for their jobs. The goal of the paper is to explain the overall notion of telecommuting and to analyze the current trends in the United States and European Union markets. Another objective is to assess the advantages and disadvantages of telecommuting and the important role played by this concept within the striving purpose of corporations to achieve their strategic targets. The study is based upon specialized literature reviews regarding the emergence of telecommuting and the role it plays in organizations. A comparative analysis was conducted by the authors on two regional markets, United States and the European Union, in order to assess the trend in telecommuting and the factors that influence it. The outcome of the research shows that although the benefits of telecommuting are numerous, it does not come without challenges, both being applicable for both the employer, as well as for the employee. The research results of this study can be used by organizations when considering to offer their employees flexible work opportunities which can positively influence the long term business performance.

  15. Overview on advanced nuclear reactors: research and deployment in the United States

    Sandell, L.; Rohrer, S.

    2004-01-01

    For the United States of America, the electricity requirement is expected to continue to rise at rates of approximately 1.8% over the next few years. This means that some 300,000 MW of additional generating capacity need to be made available by 2025. The Energy Policy Act of 2003 is to minimize this expected future growth of electricity consumption and promote research in favor of a diversified energy mix. As a consequence, the U.S. Senate and the House of Representatives passed legislation on electricity generation, on the promotion of, and research into, specific energy sources, and on energy conservation. Currently, coal-fired power plants contribute the largest share to the overall generating capacity. Considerable additions to the generating capacity have been made in the past ten years in gas-fired plants. In the light of the high present gas prices and market volatilities, the construction of new coal-fired power plants is currently under discussion. 103 out of the 436 nuclear power plants at present in operation worldwide are located in the United States. They represent by far the largest share of emission-free generating capacity in the United States. Considerable capacities have been added over the past few years by, up to now, 99 power increases by 0.4 to 17.8%. The Nuclear Power 2010 Program is a joint initiative by the government and industry seeking to further develop advanced nuclear power plant technologies and elaborate a new licensing procedure for nuclear power plants. The proposed licensing procedure and the Westinghouse AP1000, General Electric ESBWR, and AECL ACR-700 advanced reactor lines are presented. (orig.)

  16. First Author Research Productivity of United States Radiation Oncology Residents: 2002-2007

    Morgan, Peter B.; Sopka, Dennis M.; Kathpal, Madeera; Haynes, Jeffrey C.; Lally, Brian E.; Li, Linna

    2009-01-01

    Purpose: Participation in investigative research is a required element of radiation oncology residency in the United States. Our purpose was to quantify the first author research productivity of recent U.S. radiation oncology residents during their residency training. Methods and Materials: We performed a computer-based search of PubMed and a manual review of the proceedings of the annual meetings of the American Society for Therapeutic Radiology and Oncology to identify all publications and presented abstracts with a radiation oncology resident as the first author between 2002 and 2007. Results: Of 1,098 residents trained at 81 programs, 50% published ≥1 article (range, 0-9), and 53% presented ≥1 abstract (range, 0-3) at an American Society for Therapeutic Radiology and Oncology annual meeting. The national average was 1.01 articles published and 1.09 abstracts presented per resident during 4 years of training. Of 678 articles published, 82% represented original research and 18% were review articles. Residents contributed 15% of all abstracts at American Society for Therapeutic Radiology and Oncology annual meetings, and the resident contribution to orally presented abstracts increased from 12% to 21% during the study period. Individuals training at programs with >6 residents produced roughly twice as many articles and abstracts. Holman Research Pathway residents produced double the national average of articles and abstracts. Conclusion: Although variability exists among individuals and among training programs, U.S. radiation oncology residents routinely participate in investigative research suitable for publication or presentation at a scientific meeting. These data provide national research benchmarks that can assist current and future radiation oncology residents and training programs in their self-assessment and research planning.

  17. The regulation and licensing of research reactors and associated facilities in the United Kingdom

    Weightman, M.W.; Willby, C.R.

    1990-01-01

    In the United Kingdom, the Nuclear Installations Inspectorate (NII) licenses nuclear facilities, including research reactors, on behalf of the Health and Safety Executive (HSE). The legislation, the regulatory organizations and the methods of operation that have been developed over the last 30 years result in a largely non-prescriptive form of control that is well suited to research reactors. The most important part of the regulatory system is the license and the attachment of conditions which it permits. These conditions require the licensee to prepare arrangements to control the safety of the facility. In doing so the licensee is encouraged to develop a 'safety culture' within its organization. This is particularly important for research reactors which may have limited staff resources and where the ability, and at times the need, to have access to the core is much greater than for nuclear power plants. Present day issues such as the ageing of nuclear facilities, public access to the rationale behind regulatory decisions, and the emergence of more stringent safety requirements, which include a need for quantified safety criteria, have been addressed by the NII. This paper explores the relevance of such issues to the regulation of research reactors. In particular, it discusses some of the factors associated with research reactors that should be considered in developing criteria for the tolerability of risk from these nuclear facilities. From a consideration of these factors, it is the authors' view that the range of tolerable risk to the public from the operation of new research reactors may be expected to be more stringent than similar criteria for new nuclear power plants, whereas the criteria for tolerable risk for research reactor workers are expected to be about the same as those for power reactor workers

  18. A Review of Fatigue Condition in Patients with Type II Diabetes in Isfahan Endocrine and Metabolism Research Center

    Nasim Vard

    2016-07-01

    Full Text Available Complications of Diabetes such as Fatigue is a serious obstacle hindering the enhancement of health behaviors, including participation in Diabetes self-care programs, and is considered as a challenging problem for nurses and health-care providers in the process of diseases’ treatments and therapies. These complications not only influence the patients’ quality of life, but also, increases the risk of complications. Hence, regarding the importance of the role of fatigue and its subsequent effects on Diabetes’ control as well as the paucity of studies carried out in this field, the current research intended to review fatigue condition in patients with type II Diabetes in Isfahan Endocrine and Metabolism Research Center. The nature of this study is a Quantitative-Descriptive research. For the purpose of the present study, 195 patients with type II Diabetes were selected as the target sample population, based on Non-probability Convenience Sampling Method, from Isfahan Endocrine and Metabolism Research Center. To collect the research data, the researcher used a two-part written questionnaire encompassing Personal Information and Multidimensional Fatigue Symptom Inventory- Short Form (MFSI-SF as the data collection tool. Each of the participants in the present research were briefly advised about the nature and objectives of the research and they were interviewed by the researcher to complete the questionnaire after consent reached with the patients. The collected data was analyzed by SPSS16 statistical analysis software; accordingly the significance level of all the tests was estimated as P˂0.05. The results of the data analysis showed that %85.1 of the patients suffered from fatigue. There was a statistically significant difference between the mean of the severity of fatigue condition between female and male patients in the present study, i.e.23.22 ± 17.49 for women and 13.24 ± 17.73 for men, indexing a significance level of P˂0

  19. Climate change and health in the United States of America: impacts, adaptations, and research

    Jouan, R.; Magaud, M.

    2009-11-01

    After a description of the various impacts of climate change on human health, this report describes and comments the impacts of climate change on health in the USA: impacts of heat waves, of air quality degradation, of extreme climate events, of climate change on infectious diseases and allergies, regional impacts of climate change. In a second part, it describes the strategies of adaptation to the 'climate change and health' issue in the USA: mitigation and adaptation to climate change, adaptation challenges, insufficiently prepared public health system, adaptation to heat waves, adaptation to air quality degradation, adaptation to extreme climate events, adaptation to food- and water-based diseases and to vector-based diseases, examples of proactive adaptation. The last part describes the organisation of research on 'climate change and health' in the USA: nowadays and in the future, role of federal agencies, priority research axes. The 'United States Global Change Research Program' is presented in appendix, as well as the most important research centres (mostly in universities)

  20. Military Nutrition Research: Four Tasks to Address Personnel Readiness and Warfighter Performance

    Ryan, Donna

    2007-01-01

    ... and Materiel Command (USAMRMC) and PBRC, PBRC provides high quality analytical laboratory, nutrition database and metabolic unit support for military nutrition clinical research protocols. Specific Aims...

  1. 78 FR 1 - Soybean Promotion and Research: Amend the Order To Adjust Representation on the United Soybean Board

    2013-01-02

    ... practice and procedure; Advertising; Agricultural research; Marketing agreements; Soybeans and soybean...] Soybean Promotion and Research: Amend the Order To Adjust Representation on the United Soybean Board... occurred since the Board was reapportioned in 2009. As required by the Soybean Promotion, Research, and...

  2. Assessing the research and education needs of the organic dairy industry in the northeastern United States.

    Pereira, A B D; Brito, A F; Townson, L L; Townson, D H

    2013-01-01

    Demographic and management data about organic dairies have been reported previously, but the current study is the first needs assessment of research and educational priorities of organic dairy farmers in the northeastern United States based directly upon their input. Our objectives were to (1) develop an initial understanding of the emerging research and educational needs of organic dairy farmers in the northeastern United States via focus group interviews, and (2) prioritize the needs identified by the focus groups with a broader population of organic dairy farmers via survey methods. Focus group interviews determined the questions used for the survey questionnaire distributed to 1,200 members of the Northeast Organic Dairy Producers Alliance. The members were asked about demographic information, but more importantly, challenges concerning business management and marketing, organic certification, and animal nutrition, health, and reproduction. The results (183 respondents, 15% response rate) were parsed by region (New England farms compared with New York and Pennsylvania farms), herd size (i.e., 12 to 37, 38 to 59, and >60 cows), and years of organic certification (organic treatments for mastitis (92% respondents), growing forages for organic production (84%), and developing value-added products (84%). Farms with organic certification were concerned with level of knowledge and experience of local certifiers, whereas organic producers with ≥ 4 yr of organic certification were more interested in field testing of new organic products. Opportunities for educational programs included learning about direct marketing possibilities (76% respondents) and providing training to regional veterinarians interested in organic remedies (91%). In conclusion, the information obtained from the current needs assessment provides a foundation for future research proposals and educational outreach programs, germane to stakeholder needs, which could benefit the organic dairy industry

  3. Short communication: expression of transporters and metabolizing enzymes in the female lower genital tract: implications for microbicide research.

    Zhou, Tian; Hu, Minlu; Cost, Marilyn; Poloyac, Samuel; Rohan, Lisa

    2013-11-01

    Topical vaginal microbicides have been considered a promising option for preventing the male-to-female sexual transmission of HIV; however, clinical trials to date have not clearly demonstrated robust and reproducible effectiveness results. While multiple approaches may help enhance product effectiveness observed in clinical trials, increasing the drug exposure in lower genital tract tissues is a compelling option, given the difficulty in achieving sufficient drug exposure and positive correlation between tissue exposure and microbicide efficacy. Since many microbicide drug candidates are substrates of transporters and/or metabolizing enzymes, there is emerging interest in improving microbicide exposure and efficacy through local modulation of transporters and enzymes in the female lower genital tract. However, no systematic information on transporter/enzyme expression is available for ectocervical and vaginal tissues of premenopausal women, the genital sites most relevant to microbicide drug delivery. The current study utilized reverse transcriptase polymerase chain reaction (RT-PCR) to examine the mRNA expression profile of 22 transporters and 19 metabolizing enzymes in premenopausal normal human ectocervix and vagina. Efflux and uptake transporters important for antiretroviral drugs, such as P-gp, BCRP, OCT2, and ENT1, were found to be moderately or highly expressed in the lower genital tract as compared to liver. Among the metabolizing enzymes examined, most CYP isoforms were not detected while a number of UGTs such as UGT1A1 were highly expressed. Moderate to high expression of select transporters and enzymes was also observed in mouse cervix and vagina. The implications of this information on microbicide research is also discussed, including microbicide pharmacokinetics, the utilization of the mouse model in microbicide screening, as well as the in vivo functional studies of cervicovaginal transporters and enzymes.

  4. Federal research, development, and demonstration priorities for carbon dioxide removal in the United States

    Sanchez, Daniel L.; Amador, Giana; Funk, Jason; Mach, Katharine J.

    2018-01-01

    Atmospheric carbon dioxide removal (CDR) technologies may be critical to achieving deep decarbonization. Yet a lack of technical and commercial maturity of CDR technologies hinders potential deployment. Needs for commercialization span research, development, and demonstration (RD&D) activities, including development of new materials, reactors, and processes, and rigorous monitoring of a portfolio of demonstration projects. As a world leader in supporting science and engineering, the United States (US) can play an important role in reducing costs and clarifying the sustainable scale of CDR. To date, federal agencies have focused on voluntary or piecemeal CDR programs. Here, we present a synthesis of research and developement needs, relevant agency authority, barriers to coordination, and interventions to enhance RD&D across the federal government of the US. On the basis of agency authority and expertise, the Department of Energy, Department of Agriculture, Department of the Interior, National Oceanic and Atmospheric Administration, and National Science Foundation are most central to conducting research, funding projects, monitoring effects, and promulgating regulations. Key enablers for successful programs include embracing technological diversity and administrative efficiency, fostering agency buy-in, and achieving commercial deployment. Based on these criteria, the executive branch could effectively coordinate RD&D strategy through two complementary pathways: (1) renewing intra-agency commitment to CDR in five primary agencies, including both research and demonstration, and (2) coordinating research prioritization and outcomes across agencies, led by the Office of Science and Technology Policy and loosely based on the National Nanotechnology Initiative. Both pathways can be stimulated by executive order or Congressional mandate. Executive branch implementation can begin at any time; future Farm and Energy Bills provide legislative vehicles for enhancing programs.

  5. United Nations and human cloning: a slender and fortunate defence for biomedical research.

    Edwards, R G

    2003-12-01

    Numerous biomedical scientists have contributed to the wide knowledge on the growth of preimplantation human embryos in vitro, now improving every aspect of the form of clinical care. These data were gained ethically in many countries, to open new vistas including the alleviation of infertility, preimplantation genetic diagnosis and stem cells, combined with some recent reports on human reproductive cloning. After detailed consultations with scientists, clinicians, ethicists and lawyers, many governments passed legislation permitting research under their own particular socially-defined conditions. Virtually all of them rejected reproductive cloning; a few have accepted therapeutic cloning. These legislatures saluted the many biomedical scientists striving to improve IVF and its derivatives, recognizing their immense medical potential. A motion recently placed before the United Nations then recommended a worldwide ban on all forms of human cloning. Proponents included the Vatican and many Roman Catholic countries, the USA and others. Opponents included Belgium, China, Japan, Brazil, UK, Germany and France. Mediation was achieved by Iran and other Muslim nations, and led to a motion passed by single vote for a two-year delay. This may be the first-ever proposal to ban worldwide a particular form of research. It sounds the alarm bells for further research. It raises questions about the UN being an appropriate forum for ethical decisions affecting the entire world and its future medicine. Large blocs of nations committed to particular religions and outlooks confronted each other, a situation in total contrast to the detailed and widespread consultations made by individual governments when deciding their own individual ethics. This event was clearly a narrow escape for free research as defined by each country's own jurisprudence. It also places research on human embryology and reproductive biomedicine into a more critical situation than before. Current liberalism in

  6. Acidification research: evaluation and policy applications; a United Kingdom policy response

    Derwent, R.G.; Wilson, R.B.

    1992-01-01

    The United Kingdom environmental research into the mechanisms of the atmospheric transport and deposition of acidity, to understand the impacts of that acidity on soils, surface waters, forests, crops and the built environment and the consequences for fishery status, freshwater and soil ecosystems. The Critical Loads Approach opens the possibility of more subtle and sensitive ways of tackling the problems of environmental acidification on the European scale. The United Kingdom is contributing vigorously to the Critical Loads Approach through the mapping exercises, the environmental studies that underpin them and the understanding of the driving deposition mechanisms which lead both to pollutant removal and ecosystem contamination. Future progress with the UN ECE Convention on the Long Range Transport of Air Pollution and the revision of the NO x , SO 2 and VOC protocols will rest in very large measure on the shared confidence within Europe in the knowledge of the underpinning environmental science. The Critical Loads Approach should provide an important policy focus within the international scientific community to set environmentally-based targets for future co-ordinated emission control programmes

  7. Software architecture for a multi-purpose real-time control unit for research purposes

    Epple, S.; Jung, R.; Jalba, K.; Nasui, V.

    2017-05-01

    A new, freely programmable, scalable control system for academic research purposes was developed. The intention was, to have a control unit capable of handling multiple PT1000 temperature sensors at reasonable accuracy and temperature range, as well as digital input signals and providing powerful output signals. To take full advantage of the system, control-loops are run in real time. The whole eight bit system with very limited memory runs independently of a personal computer. The two on board RS232 connectors allow to connect further units or to connect other equipment, as required in real time. This paper describes the software architecture for the third prototype that now provides stable measurements and an improvement in accuracy compared to the previous designs. As test case a thermal solar system to produce hot tap water and assist heating in a single-family house was implemented. The solar fluid pump was power-controlled and several temperatures at different points in the hydraulic system were measured and used in the control algorithms. The software architecture proved suitable to test several different control strategies and their corresponding algorithms for the thermal solar system.

  8. Research Regarding the Anticorosiv Protection of Atmospheric and Vacuum Distillation Unit that Process Crude Oil

    M. Morosanu

    2011-12-01

    Full Text Available Due to high boiling temperature, organic acids are present in the warmer areas of metal equipment from atmospheric and vacuum distillation units and determine, increased corrosion processes in furnace tubes, transfer lines, metal equipment within the distillation columns etc. In order to protect the corrosion of metal equipment from atmospheric and vacuum distillation units, against acids, de authors researched solution which integrates corrosion inhibitors and selecting materials for equipment construction. For this purpose, we tested the inhibitor PET 1441, which has dialchilfosfat in his composition and inhibitor based on phosphate ester. In this case, to the metal surface forms a complex phosphorous that forms of high temperature and high fluid speed. In order to form the passive layer and to achieve a 90% protection, we initially insert a shock dose, and in order to ensure further protection there is used a dose of 20 ppm. The check of anticorrosion protection namely the inhibition efficiency is achieved by testing samples made from steel different.

  9. Oil and chemical spill research and development in the United Kingdom

    Goodman, C.

    1992-01-01

    The Marine Pollution Control Unit (MPCU) falls within the UK Department of Transport's Marine Directorate and is the lead agency in the UK for the control of marine pollution. The MPCU assumes central government's responsibility for controlling two aspects of marine pollution: at sea response to oil and chemical spills from ships, and coordinating beach cleaning activities. All research funded by the MPCU is therefore directed at these two responsibilities. The MPCU was established in 1978 after a series of major tanker incidents in European waters (notably the AMOCO CADIZ, France) in recognition of the fact that it was not reasonable to expect the owners of tankers which operate on a world-wide basis to make arrangements for dealing with oil spills wherever they may occur. The UK Government therefore decided to set up a response unit, the MPCU, with specific responsibilities for dealing with oil and chemical spills from ships at sea. The responsibility for dealing with pollution once it comes ashore lies with the local authorities. However, to avoid expenditure by individual authorities on specialized equipment which will be rarely required, the government decided to set up stockpiles of such equipment in strategic locations to be drawn on by authorities as and when necessary. The government also provides training in the use of this equipment, offers scientific and technical advice and, for major spills, will coordinate beach cleaning activities

  10. Sustainable source of omega-3 eicosapentaenoic acid from metabolically engineered Yarrowia lipolytica: from fundamental research to commercial production.

    Xie, Dongming; Jackson, Ethel N; Zhu, Quinn

    2015-02-01

    The omega-3 fatty acids, cis-5, 8, 11, 14, and 17-eicosapentaenoic acid (C20:5; EPA) and cis-4, 7, 10, 13, 16, and 19-docosahexaenoic acid (C22:6; DHA), have wide-ranging benefits in improving heart health, immune function, mental health, and infant cognitive development. Currently, the major source for EPA and DHA is from fish oil, and a minor source of DHA is from microalgae. With the increased demand for EPA and DHA, DuPont has developed a clean and sustainable source of the omega-3 fatty acid EPA through fermentation using metabolically engineered strains of Yarrowia lipolytica. In this mini-review, we will focus on DuPont's technology for EPA production. Specifically, EPA biosynthetic and supporting pathways have been introduced into the oleaginous yeast to synthesize and accumulate EPA under fermentation conditions. This Yarrowia platform can also produce tailored omega-3 (EPA, DHA) and/or omega-6 (ARA, GLA) fatty acid mixtures in the cellular lipid profiles. Fundamental research such as metabolic engineering for strain construction, high-throughput screening for strain selection, fermentation process development, and process scale-up were all needed to achieve the high levels of EPA titer, rate, and yield required for commercial application. Here, we summarize how we have combined the fundamental bioscience and the industrial engineering skills to achieve large-scale production of Yarrowia biomass containing high amounts of EPA, which led to two commercial products, New Harvest™ EPA oil and Verlasso® salmon.

  11. Renewable energies in the United States: support policies and tendencies for research and development

    2009-11-01

    Illustrated by figures, graphs and tables of data, nine articles give overviews of the present evolutions and tendencies for research and development in the energy sector in the United States of America. After a first article commenting the possible evolution of the energy model in this country, the authors are commenting the priority given to innovation for clean energies, the evolution of patents claimed by US companies, the smart-grid-based energy strategy, the evolution of the wind energy sector, the technological evolutions and decreasing prices of the solar energy, the large investments required for a large scale development of geothermal energy, the voluntary policy and the ambitious objectives in the field of bio-energies and bio-fuels, and California as a leader in the field of renewable energies

  12. Research on optimization of combustion efficiency of thermal power unit based on genetic algorithm

    Zhou, Qiongyang

    2018-04-01

    In order to improve the economic performance and reduce pollutant emissions of thermal power units, the characteristics of neural network in establishing boiler combustion model are analyzed based on the analysis of the main factors affecting boiler efficiency by using orthogonal method. In addition, on the basis of this model, the genetic algorithm is used to find the best control amount of the furnace combustion in a certain working condition. Through the genetic algorithm based on real number encoding and roulette selection is concluded: the best control quantity at a condition of furnace combustion can be combined with the boiler combustion system model for neural network training. The precision of the neural network model is further improved, and the basic work is laid for the research of the whole boiler combustion optimization system.

  13. Developmental process and early phases of implementation for the United States Interagency Committee on Human Nutrition Research National Nutrition Research Roadmap

    The United States Congress first called for improved coordination of human nutrition research within and among federal departments and agencies in the 1977 Farm Bill. Today, the Interagency Committee on Human Nutrition Research (ICHNR) is charged with improving the planning, coordination, and commu...

  14. Arthropod genomics research in the United States Department of Agriculture-Agricultural Research Service: Applications of RNA interference and CRISPR gene editing technologies in pest control

    The Agricultural Research Service (ARS) is the intramural research agency of the United States Department of Agriculture (USDA) which addresses basic scientific questions and develops applied solutions to a range of agricultural problems, and in doing so protects national food security and supports ...

  15. An Ergonomic Evaluation of the Extravehicular Mobility Unit (EMU) Space Suit Hard Upper Torso (HUT) Size Effect on Metabolic, Mobility, and Strength Performance

    Reid, Christopher; Harvill, Lauren; England, Scott; Young, Karen; Norcross, Jason; Rajulu, Sudhakar

    2014-01-01

    The objective of this project was to assess the performance differences between a nominally sized Extravehicular Mobility Unit (EMU) space suit and a nominal +1 (plus) sized EMU. Method: This study evaluated suit size conditions by using metabolic cost, arm mobility, and arm strength as performance metrics. Results: Differences between the suit sizes were found only in shoulder extension strength being 15.8% greater for the plus size. Discussion: While this study was able to identify motions and activities that were considered to be practically or statistically different, it does not signify that use of a plus sized suit should be prohibited. Further testing would be required that either pertained to a particular mission critical task or better simulates a microgravity environment that the EMU suit was designed to work in.

  16. Food Insecurity and Its Association With Central Obesity and Other Markers of Metabolic Syndrome Among Persons Aged 12 to 18 Years in the United States.

    Holben, David H; Taylor, Christopher A

    2015-09-01

    Food insecurity is a preventable health threat and may precipitate central obesity and metabolic syndrome in children and adolescents in the United States. To examine (1) health by household food security status; and (2) differences and prevalence of central obesity among persons aged 12 to 18 years in the United States. The National Health and Nutrition Examination Survey was administered to a cross-sectional sample of persons aged 12 to 18 years in 1999 to 2006. Controlling for age, race/ethnicity, and sex differences in mean obesity and chronic disease factors across levels of food insecurity (analysis of covariance [Bonferroni post hoc] and ORs [logistic regression analyses]) were examined, as were differences in the rates of risk factors (χ(2) statistics). A total of 7435 participants were analyzed. Those from marginally food secure (n=751) and low-food secure (n=1206) (population size estimate, 26,714,182) households were significantly more likely than their high-food secure counterparts (n=4831) to be overweight (P=.036) (OR, 1.44), and those from marginally food secure households were 1.3-times more likely to be obese (P=.036). Nearly 25% of respondents from marginally food secure, low-food secure, and very low-food secure (n=647) households reported central obesity (P=.002), which was 1.4 to 1.5 times more likely than those from high-food secure households. Participants from high-food secure households had significantly higher mean high-density lipoprotein values (P=.019). Risk factors indicative of metabolic syndrome were present in 3.1%. Household food insecurity was associated with an increased likelihood of being overweight and having central obesity. Limitations included the use of cross-sectional data and some self-reported data and the inability to control for all moderating variables in obesity and overall health status.

  17. Research needs for strandplain/barrier island reservoirs in the United States

    Cole, E.L.; Fowler, M.L.; Salamy, S.P.; Sarathi, P.S.; Young, M.A.

    1994-12-01

    This report identifies reservoir characterization and reservoir management research needs and IOR process and related research needs for the fourth geologic class, strandplain/barrier island reservoirs. The 330 Class 4 reservoirs in the DOE Tertiary OH Recovery Information System (TORIS) database contain about 30.8 billion barrels of oil or about 9% of the total original oil-in-place (OOIP) in all United States reservoirs. The current projection of Class 4 ultimate recovery with current operations is only 38% of the OOIP, leaving 19 billion barrels as the target for future IOR projects. Using the TORIS database and its predictive and economic models, the recovery potential which could result from future application of IOR technologies to Class 4 reservoirs was estimated to be between 1.0 and 4.3 billion barrels, depending on oil price and the level of technology advancement. The analysis indicated that this potential could be realized through (1) infill drilling alone and in combination with polymer flooding and profile modification, (2) chemical flooding (surfactant), and (3) thermal processes. Most of this future potential is in Texas, Oklahoma, California, and the Rocky Mountain region. Approximately two-thirds of the potentially recoverable resource is at risk of abandonment by the year 2000, which emphasizes the urgent need for the development and demonstration of cost-effective recovery technologies.

  18. Estimating the returns to United Kingdom publicly funded musculoskeletal disease research in terms of net value of improved health outcomes.

    Glover, Matthew; Montague, Erin; Pollitt, Alexandra; Guthrie, Susan; Hanney, Stephen; Buxton, Martin; Grant, Jonathan

    2018-01-10

    Building on an approach applied to cardiovascular and cancer research, we estimated the economic returns from United Kingdom public- and charitable-funded musculoskeletal disease (MSD) research that arise from the net value of the improved health outcomes in the United Kingdom. To calculate the economic returns from MSD-related research in the United Kingdom, we estimated (1) the public and charitable expenditure on MSD-related research in the United Kingdom between 1970 and 2013; (2) the net monetary benefit (NMB), derived from the health benefit in quality adjusted life years (QALYs) valued in monetary terms (using a base-case value of a QALY of £25,000) minus the cost of delivering that benefit, for a prioritised list of interventions from 1994 to 2013; (3) the proportion of NMB attributable to United Kingdom research; and (4) the elapsed time between research funding and health gain. The data collected from these four key elements were used to estimate the internal rate of return (IRR) from MSD-related research investments on health benefits. We analysed the uncertainties in the IRR estimate using a one-way sensitivity analysis. Expressed in 2013 prices, total expenditure on MSD-related research from 1970 to 2013 was £3.5 billion, and for the period used to estimate the rate of return, 1978-1997, was £1.4 billion. Over the period 1994-2013 the key interventions analysed produced 871,000 QALYs with a NMB of £16 billion, allowing for the net NHS costs resulting from them and valuing a QALY at £25,000. The proportion of benefit attributable to United Kingdom research was 30% and the elapsed time between funding and impact of MSD treatments was 16 years. Our best estimate of the IRR from MSD-related research was 7%, which is similar to the 9% for CVD and 10% for cancer research. Our estimate of the IRR from the net health gain to public and charitable funding of MSD-related research in the United Kingdom is substantial, and justifies the research investments

  19. Establishing research strategies, methodologies and technologies to link genomics and proteomics to seagrass productivity, community metabolism, and ecosystem carbon fluxes.

    Mazzuca, Silvia; Björk, M; Beer, S; Felisberto, P; Gobert, S; Procaccini, G; Runcie, J; Silva, J; Borges, A V; Brunet, C; Buapet, P; Champenois, W; Costa, M M; D'Esposito, D; Gullström, M; Lejeune, P; Lepoint, G; Olivé, I; Rasmusson, L M; Richir, J; Ruocco, M; Serra, I A; Spadafora, A; Santos, Rui

    2013-01-01

    A complete understanding of the mechanistic basis of marine ecosystem functioning is only possible through integrative and interdisciplinary research. This enables the prediction of change and possibly the mitigation of the consequences of anthropogenic impacts. One major aim of the European Cooperation in Science and Technology (COST) Action ES0609 "Seagrasses productivity. From genes to ecosystem management," is the calibration and synthesis of various methods and the development of innovative techniques and protocols for studying seagrass ecosystems. During 10 days, 20 researchers representing a range of disciplines (molecular biology, physiology, botany, ecology, oceanography, and underwater acoustics) gathered at The Station de Recherches Sous-marines et Océanographiques (STARESO, Corsica) to study together the nearby Posidonia oceanica meadow. STARESO is located in an oligotrophic area classified as "pristine site" where environmental disturbances caused by anthropogenic pressure are exceptionally low. The healthy P. oceanica meadow, which grows in front of the research station, colonizes the sea bottom from the surface to 37 m depth. During the study, genomic and proteomic approaches were integrated with ecophysiological and physical approaches with the aim of understanding changes in seagrass productivity and metabolism at different depths and along daily cycles. In this paper we report details on the approaches utilized and we forecast the potential of the data that will come from this synergistic approach not only for P. oceanica but for seagrasses in general.

  20. 78 FR 12369 - United States Government Policy for Institutional Oversight of Life Sciences Dual Use Research of...

    2013-02-22

    ... Oversight of Life Sciences Dual Use Research of Concern AGENCY: Office of Science and Technology Policy... comments on the proposed United States Government Policy for Institutional Oversight of Life Sciences Dual... requirements for certain categories of life sciences research at institutions that accept Federal funding for...

  1. A Review of Underground Coal Gasification Research and Development in the United States

    Camp, D. W. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-06-26

    An intense and productive period of research and development on underground coal gasification (UCG) took place in the United States from the mid-1970’s through the late 1980’s. It began with the translation and review of Soviet literature and ended with the Rocky Mountain 1 field test. This demonstrated the feasibility of newly-developed technologies that form the basis of many UCG projects around the world today. This period began with little domestic understanding of UCG and ended with an accurate observation-based conceptual model and a corresponding predictive multi-physics mathematical model of the process. The many accomplishments of this period form the main content of this report. This report also covers recent U.S. activities and accomplishments during the period 2004-2015, and touches briefly on the Bureau of Mines efforts between 1948 and 1963. Most of the activities were funded by the United States Department of Energy and its predecessors. While private/commercially-funded activities are reviewed here, the emphasis is on government-funded work. It has a much greater extent of publicly available reports and papers, and they generally contain much greater technical detail. Field tests were the marquis activities around which an integrated multi-faceted program was built. These are described in detail in Section 4. Highlights from modeling efforts are briefly covered, as the program was integrated and well-rounded, with field results informing models and vice-versa. The primary goal of this report is to review what has been learned about UCG from the U.S. experience in aggregate. This includes observations, conclusions, lessons-learned, phenomena understood, and technology developed. The latter sections of this report review these things.

  2. Protection of human subjects of biomedical research in the United States. A contrast with recent experience in the United Kingdom.

    Levine, R J

    1988-01-01

    In the U.S., the development of extensive regulations for the protection of human subjects of research began in the 1960s and continued through the 1970s. The substance of these regulations reflects the American social and political climate of the time. There is a focus on rights--e.g., to be left alone, to be self-determining--reflected in elaborate requirements to assure the validity and documentation of informed consent. There is also a focus on systems of disinterested review and monitoring procedures to assure uniform adherence to the requirements of the regulations. To the extent that the U.S. has developed extensive regulations in this field, it may be viewed as more advanced than the U.K. And yet, it is apparent that there remain on both sides of the Atlantic very difficult and similar problems regarding the definition of responsible research. Such problems are illustrated by consideration of current controversies about the ethical justification of RCTs. There are some features of the U.S. regulatory system that I can commend to the attention of other nations as they develop policies for the protection of human research subjects. For example, a uniform requirement for informed consent and committee review appears to be responsive to some problems currently encountered in the conduct of RCTs in the U.K. A note of caution is in order, however. Some features of our regulatory policy and practices are excessively inflexible, wasteful of human resources, and occasionally counterproductive.

  3. Preregistration research training of speech and language therapists in the United Kingdom: a nationwide audit of quantity, content and delivery.

    Pagnamenta, Emma; Joffe, Victoria L

    2018-04-24

    To carry out an audit of the quantity and content of research teaching on UK preregistration speech and language therapy (SLT) degree programmes. Lecturers delivering research teaching from each higher education institution providing preregistration training were invited to complete an online survey. Amount of research teaching, content of research teaching (including final-year projects), perceived confidence by staff of graduates in research awareness, research activity and leading research. Responses were received for 14 programmes (10 undergraduate and four postgraduate), representing 73% of all undergraduate courses and 44% of all postgraduate courses in the United Kingdom. Fifty percent of courses included over 30 h of research teaching, with wide variability across both undergraduate and postgraduate courses in number of hours, modules and credits devoted to research. There was no association between quantity of research teaching and perception of adequacy of quantity of teaching. Critical appraisal, statistical software and finding literature were the most common topics taught. Conversely, service evaluation and audit was the least common topic covered. All institutions provided a final-year project, with 11/14 requiring empirical research. Perceived confidence of graduates was higher for research awareness than active research and leading research, but this varied across institutions. There was a strong correlation between lecturers' perceived confidence of graduates in research awareness and number of hours of research teaching. Despite the requirements for healthcare professionals to engage in evidence-based practice, the amount and nature of research training in preregistration courses for SLTs in the United Kingdom is highly variable. Levels of perceived confidence of graduates were also variable, not only for active participation in research, and for leading research, but also for research awareness. This has implications for the ability of SLTs to

  4. Building visual identity of scientific and research units and the role of visualization in cooperation with business

    Alfreda Kamińska

    2014-12-01

    Full Text Available The need for commercialization of scientific research leads to the necessity of changing the orientation of scientific-research units to marketing orientation, which is characterized by, among others, conducting research aimed at learning the clients’ needs and building better communication with the recipients. What is an important element of a unit’s marketing communication is its visual identity system, which the recipients use to build their opinion and their picture of the unit. The goal of this article is an attempt to define the key rules of designing visual identity of scientific and research institutions, as well as presenting the role of visualization in their cooperation with business. In the article the notions of image, identity, corporate identity and visual identity are subject to analysis. The article also presents the significance of visualization in the functioning of research and scientific units, elements of visual identity system and the rules of designing visual identity of scientific and research institutions. An analysis of chosen research-scientific units was carried out with regard to visualization.

  5. Involvement of consumers in studies run by the Medical Research Council Clinical Trials Unit: Results of a survey

    Vale Claire L

    2012-01-01

    Full Text Available Abstract Background We aimed to establish levels of consumer involvement in randomised controlled trials (RCTs, meta-analyses and other studies carried out by the UK Medical Research Council (MRC Clinical Trials Unit across the range of research programs, predominantly in cancer and HIV. Methods Staff responsible for studies that were included in a Unit Progress Report (MRC CTU, April 2009 were asked to complete a semi-structured questionnaire survey regarding consumer involvement. This was defined as active involvement of consumers as partners in the research process and not as subjects of that research. The electronic questionnaires combined open and closed questions, intended to capture quantitative and qualitative information on whether studies had involved consumers; types of activities undertaken; recruitment and support; advantages and disadvantages of involvement and its perceived impact on aspects of the research. Results Between October 2009 and April 2010, 138 completed questionnaires (86% were returned. Studies had been conducted over a 20 year period from 1989, and around half were in cancer; 30% in HIV and 20% were in other disease areas including arthritis, tuberculosis and blood transfusion medicine. Forty-three studies (31% had some consumer involvement, most commonly as members of trial management groups (TMG [88%]. A number of positive impacts on both the research and the researcher were identified. Researchers generally felt involvement was worthwhile and some felt that consumer involvement had improved the credibility of the research. Benefits in design and quality, trial recruitment, dissemination and decision making were also perceived. Researchers felt they learned from consumer involvement, albeit that there were some barriers. Conclusions Whilst most researchers identified benefits of involving consumers, most of studies included in the survey had no involvement. Information from this survey will inform the development

  6. Involvement of consumers in studies run by the Medical Research Council Clinical Trials Unit: results of a survey.

    Vale, Claire L; Thompson, Lindsay C; Murphy, Claire; Forcat, Silvia; Hanley, Bec

    2012-01-13

    We aimed to establish levels of consumer involvement in randomised controlled trials (RCTs), meta-analyses and other studies carried out by the UK Medical Research Council (MRC) Clinical Trials Unit across the range of research programs, predominantly in cancer and HIV. Staff responsible for studies that were included in a Unit Progress Report (MRC CTU, April 2009) were asked to complete a semi-structured questionnaire survey regarding consumer involvement. This was defined as active involvement of consumers as partners in the research process and not as subjects of that research. The electronic questionnaires combined open and closed questions, intended to capture quantitative and qualitative information on whether studies had involved consumers; types of activities undertaken; recruitment and support; advantages and disadvantages of involvement and its perceived impact on aspects of the research. Between October 2009 and April 2010, 138 completed questionnaires (86%) were returned. Studies had been conducted over a 20 year period from 1989, and around half were in cancer; 30% in HIV and 20% were in other disease areas including arthritis, tuberculosis and blood transfusion medicine. Forty-three studies (31%) had some consumer involvement, most commonly as members of trial management groups (TMG) [88%]. A number of positive impacts on both the research and the researcher were identified. Researchers generally felt involvement was worthwhile and some felt that consumer involvement had improved the credibility of the research. Benefits in design and quality, trial recruitment, dissemination and decision making were also perceived. Researchers felt they learned from consumer involvement, albeit that there were some barriers. Whilst most researchers identified benefits of involving consumers, most of studies included in the survey had no involvement. Information from this survey will inform the development of a unit policy on consumer involvement, to guide future

  7. Talent Development Research, Policy, and Practice in Europe and the United States: Outcomes from a Summit of International Researchers

    Subotnik, Rena F.; Stoeger, Heidrun; Olszewski-Kubilius, Paula

    2017-01-01

    The goal of this article is to convey a summary of research and conversation on talent development on the part of a small group of European and American researchers who participated in the Inaugural American European Research Summit in Washington. In the final hours of the summit, participants discussed the state of research on talent development…

  8. Report by the AERES on the unit: Research Unit on Reactor Safety under the supervision of the establishments and bodies: Radioprotection and Nuclear Safety Institute

    2010-10-01

    This report is a kind of audit report on a research laboratory whose activity is organized according to the following themes: behaviour of nuclear fuel under accidental conditions, core fusion accidents, fire in confined environment, and civil engineering and structure behaviour. The authors discuss an assessment of the unit activities in terms of strengths and opportunities, aspects to be improved and recommendations, productions and publications. A more detailed assessment is presented in terms of scientific quality, influence and attractiveness (awards, recruitment capacity, capacity to obtain financing and to tender, participation to international programs), strategy and governance, and project. Each research theme is analyzed in the same way

  9. Addiction research centres and the nurturing of creativity: The Alcohol & Drug Abuse Research Unit at the South African Medical Research Council - strengthening substance abuse research and policy in South Africa.

    Parry, Charles; Morojele, Neo; Myers, Bronwyn; Plüddemann, Andreas

    2013-01-01

    The Alcohol and Drug Abuse Research Unit (ADARU) was established at the South African Medical Research Council (MRC) at the beginning of 2001, although its origins lie in the activities of the Centre for Epidemiological Research in Southern Africa and other MRC entities. Initial challenges included attracting external funding, recruiting new staff, developing the skills of junior staff, publishing in international journals and building national and international collaborative networks. ADARU currently comprises a core staff of 33 members who work on 22 projects spanning substance use epidemiology and associated consequences, intervention studies with at-risk populations and services research. A large component of this portfolio focuses on the link between alcohol and other drug use and human immunodeficiency virus (HIV) risk behaviour, with funding from the US Centers for Disease Control and Prevention. Junior staff members are encouraged to develop independent research interests and pursue PhD studies. Research outputs, such as the 20 papers that were published in 2010 and the 35 conference presentations from that year, form an important part of the unit's research translation activities. We engage actively with policy processes at the local, provincial, national and international levels, and have given particular attention to alcohol policy in recent years. The paper includes an analysis of major challenges currently facing the unit and how we are attempting to address them. It ends with some thoughts on what the unit intends doing to enhance the quality of its research, the capacity of its staff and its international standing. © 2011 The Authors, Addiction © 2011 Society for the Study of Addiction.

  10. The Applied Meteorology Unit: Nineteen Years Successfully Transitioning Research into Operations for America's Space Program

    Madura, John T.; Bauman, William H.; Merceret, Francis J.; Roeder, William P.; Brody, Frank C.; Hagemeyer, Bartlett C.

    2010-01-01

    The Applied Meteorology Unit (AMU) provides technology transition and technique development to improve operational weather support to the Space Shuttle and the entire American space program. The AMU is funded and managed by NASA and operated by a contractor that provides five meteorologists with a diverse mix of advanced degrees, operational experience, and associated skills including data processing, statistics, and the development of graphical user interfaces. The AMU's primary customers are the U.S. Air Force 45th Weather Squadron at Patrick Air Force Base, the National Weather Service Spaceflight Meteorology Group at NASA Johnson Space Center, and the National Weather Service Melbourne FL Forecast Office. The AMU has transitioned research into operations for nineteen years and worked on a wide range of topics, including new forecasting techniques for lightning probability, synoptic peak winds,.convective winds, and summer severe weather; satellite tools to predict anvil cloud trajectories and evaluate camera line of sight for Space Shuttle launch; optimized radar scan strategies; evaluated and implemented local numerical models; evaluated weather sensors; and many more. The AMU has completed 113 projects with 5 more scheduled to be completed by the end of 2010. During this rich history, the AMU and its customers have learned many lessons on how to effectively transition research into operations. Some of these lessons learned include collocating with the operational customer and periodically visiting geographically separated customers, operator submitted projects, consensus tasking process, use of operator primary advocates for each project, customer AMU liaisons with experience in both operations and research, flexibility in adapting the project plan based on lessons learned during the project, and incorporating training and other transition assistance into the project plans. Operator involvement has been critical to the AMU's remarkable success and many awards

  11. Establishing research strategies, methodologies and technologies to link genomics and proteomics to seagrass productivity, community metabolism and ecosystem carbon fluxes

    Silvia eMazzuca

    2013-03-01

    Full Text Available A complete understanding of the mechanistic basis of marine ecosystem functioning is only possible through integrative and interdisciplinary research. This enables the prediction of change and possibly the mitigation of the consequences of anthropogenic impacts. One major aim of the COST Action ES0609 Seagrasses productivity. From genes to ecosystem management, is the calibration and synthesis of various methods and the development of innovative techniques and protocols for studying seagrass ecosystems.During ten days, twenty researchers representing a range of disciplines (molecular biology, physiology, botany, ecology, oceanography, underwater acoustics gathered at the marine station of STARESO (Corsica to study together the nearby Posidonia oceanica meadow. The Station de Recherches Sous-marine et Océanographiques (STARESO is located in an oligotrophic area classified as "pristine site" where environmental disturbances caused by anthropogenic pressure are exceptionally low. The healthy P. oceanica meadow, that grows in front of the lab, colonizes the sea bottom from the surface to 37 m depth. During the study, genomic and proteomic approaches were integrated with ecophysiological and physical approaches with the aim of understanding changes in seagrass productivity and metabolism at different depths and along daily cycles. In this paper we report details on the approaches utilized and we forecast the potential of the data that will come from this synergistic approach not only for P. oceanica but for seagrasses in general.

  12. Government financial support for civil aircraft research, technology and development in four European countries and the United States

    Chandler, B.; Golaszewski, R.; Patten, C.; Rudman, B.; Scott, R.

    1980-01-01

    Data on the levels of government financial support for civil aircraft airframe and engine (CAAE) research and technology (R&T) in the United States and Europe (United Kingdom, West Germany, France and The Netherlands) and means of comparing these levels are provided. Data are presented for the years 1974-1977. European R&T expenditure data were obtained through visits to each of the four European countries, to the Washington office of the European Communities, and by a search of applicable literature. CAAE R&T expenditure data for the United States were obtained from NASA and Federal Aviation Administration (FAA).

  13. Pilot research projects for underground disposal of radioactive wastes in the United States of America

    Stein, R.; Collyer, P.L.

    1984-01-01

    Disposal of commercial radioactive waste in the United States of America in a deep underground formation will ensure permanent isolation from the biosphere with minimal post-closure surveillance and maintenance. The siting, design and development, performance assessment, operation, licensing, certification and decommissioning of an underground repository have stimulated the development of several pilot research projects throughout the country. These pilot tests and projects, along with their resulting data base, are viewed as important steps in the overall location and construction of a repository. Beginning in the 1960s, research at pilot facilities has progressed from underground spent fuel tests in an abandoned salt mine to the production of vitrified nuclear waste in complex borosilicate glass logs. Simulated underground repository experiments have been performed in the dense basalts of Washington State, the volcanic tuffaceous rock of Nevada and both domal and bedded salts of Louisiana and Kansas. In addition to underground pilot in situ tests, other facilities have been constructed or modified to monitor the performance of spent fuel in dry storage wells and self-shielded concrete casks. As the National Waste Terminal Storage (NWTS) programme advances to the next stage of underground site characterization for each of three different geological sites, additional pilot facilities are under consideration. These include a Test and Evaluation Facility (TEF) for site verification and equipment performance and testing, as well as a salt testing facility for verification of in situ simulation equipment. Although not associated with the NWTS programme, the construction of the Waste Isolation Pilot Plant (WIPP) in the bedded salts of New Mexico is well under way for deep testing and experimentation with the defence programme's transuranic nuclear waste. (author)

  14. Summary and abstracts: Applied Research Units and Projects 1996 UCETF Program

    NONE

    1999-05-21

    The Urban Consortium (UC), created by PTI, is a network of jurisdictions with populations of over 250,000. The UC provides a platform for research and enterprise through its Energy, Environmental, Transportation, and Telecommunications and Information Task Forces. The UC provides a unique creative forum where elected and appointed officials and technical managers identify, test, and validate practical ways to improve the provision of public services and, where possible, generate new revenue opportunities. Public Technology, Inc., is the non-profit technology organization of the National League of Cities, the National Association of Counties, and the International City/County Management Association. PTI creates and advances technology-based products, services, and enterprises in cities and counties nationwide. Staffed by PTI, the UC addresses the critical needs of local governments through its Task Forces. The Urban Consortium Energy Task Force (UCETF) program has, since its inception, acted as a laboratory to develop, test solutions and share the resulting products or management approaches with the wider audience of local governments. It has addressed the overlap between energy and environment and economic development policy issues, and, is the nation's most extensive cooperative local government program to improve energy management and decision-making through applied research and technology cooperation. Proposals to meet the specific objectives of the UCETF annual R and D program are solicited from major urban jurisdictions. Projects based on these proposals are then selected by the UCETF for direct conduct and management by staff of city and county governments. Projects selected for each year's program are organized in thematic units to assure effective management and ongoing peer-to-peer experience exchange, with results documented at the end of each program year.

  15. Gender Authorship Trends of Plastic Surgery Research in the United States.

    Silvestre, Jason; Wu, Liza C; Lin, Ines C; Serletti, Joseph M

    2016-07-01

    An increasing number of women are entering the medical profession, but plastic surgery remains a male-dominated profession, especially within academia. As academic aspirations and advancement depend largely on research productivity, the authors assessed the number of articles authored by women published in the journal Plastic and Reconstructive Surgery. Original articles in Plastic and Reconstructive Surgery published during the years 1970, 1980, 1990, 2000, 2004, and 2014 were analyzed. First and senior authors with an M.D. degree and U.S. institutional affiliation were categorized by gender. Authorship trends were compared with those from other specialties. Findings were placed in the context of gender trends among plastic surgery residents in the United States. The percentage of female authors in Plastic and Reconstructive Surgery increased from 2.4 percent in 1970 to 13.3 percent in 2014. Over the same time period, the percentage of female plastic surgery residents increased from 2.6 percent to 32.5 percent. By 2014, there were more female first authors (19.1 percent) than senior authors (7.7 percent) (p < 0.001). As a field, plastic surgery had fewer female authors than other medical specialties including pediatrics, obstetrics and gynecology, general surgery, internal medicine, and radiation oncology (p < 0.05). The increase in representation of female authors in plastic surgery is encouraging but lags behind advances in other specialties. Understanding reasons for these trends may help improve gender equity in academic plastic surgery.

  16. Radioisotope Heater Unit-Based Stirling Power Convertor Development at NASA Glenn Research Center

    Wilson, Scott D.; Geng, Steven M.; Penswick, Lawrence; Schmitz, Paul C.

    2017-01-01

    Stirling Radioisotope Power Systems (RPS) are being developed as an option to provide power on future space science missions where robotic spacecraft will orbit, flyby, land or rove. A variety of mission concepts have been studied by NASA and the U. S. Department of Energy that would utilize RPS for landers, probes, and rovers and only require milliwatts to tens of watts of power. These missions would contain science measuring instruments that could be distributed across planetary surfaces or near objects of interest in space solar flux insufficient for using solar cells. A low power Stirling convertor is being developed to provide an RPS option for future low power applications. Initial concepts convert heat available from several Radioisotope Heater Units to electrical power for spacecraft instruments and communication. Initial development activity includes defining and evaluating a variety of Stirling configurations and selecting one for detailed design, research of advanced manufacturing methods that could simplify fabrication, evaluating thermal interfaces, characterizing components and subassemblies to validate design codes, and preparing for an upcoming demonstration of proof of concept in a laboratory environment.

  17. Apelin Role in the Development of Glucose Metabolism Disorders (Review of the Literature and Our Own Researches

    G.V. Demidenko

    2014-05-01

    Full Text Available The physiological and pathogenetic role of adipokine apelin, endogenous ligand of apelin (APJ or APLNR receptors in the development of glucose metabolism disorders has been analyzed. Established correlations of apelin with components of carbohydrate metabolism confirm the effect on glucose metabolism manifestations. Ambiguous data about apelin level at insulin resistance syndrome, prediabetes, diabetes mellitus type 2, hypertension require further detailed study. The close association of apelin with development of diabetes mellitus type 2 and prediction of cardiovascular events in patients with metabolic syndrome has been found.

  18. Adherence: a review of education, research, practice, and policy in the United States

    Brown TA

    2010-03-01

    Full Text Available Objective: To describe the education, research, practice, and policy related to pharmacist interventions to improve medication adherence in community settings in the United States.Methods: Authors used MEDLINE and International Pharmaceutical Abstracts (since 1990 to identify community and ambulatory pharmacy intervention studies which aimed to improve medication adherence. The authors also searched the primary literature using Ovid to identify studies related to the pharmacy teaching of medication adherence. The bibliographies of relevant studies were reviewed in order to identify additional literature. We searched the tables of content of three US pharmacy education journals and reviewed the American Association of Colleges of Pharmacy website for materials on teaching adherence principles. Policies related to medication adherence were identified based on what was commonly known to the authors from professional experience, attendance at professional meetings, and pharmacy journals.Results: Research and Practice: 29 studies were identified: 18 randomized controlled trials; 3 prospective cohort studies; 2 retrospective cohort studies; 5 case-controlled studies; and one other study. There was considerable variability in types of interventions and use of adherence measures. Many of the interventions were completed by pharmacists with advanced clinical backgrounds and not typical of pharmacists in community settings. The positive intervention effects had either decreased or not been sustained after interventions were removed. Although not formally assessed, in general, the average community pharmacy did not routinely assess and/or intervene on medication adherence. Education: National pharmacy education groups support the need for pharmacists to learn and use adherence-related skills. Educational efforts involving adherence have focused on students’ awareness of adherence barriers and communication skills needed to engage patients in behavioral

  19. Cooperative Fish and Wildlife Research Units Program—2016 year in review

    Organ, John F.; Thompson, John D.; Dennerline, Donald E.; Childs, Dawn E.

    2017-02-22

    SummaryThe Cooperative Fish and Wildlife Research Units (CRU) Program had a productive year in 2016. Despite vacancies in our scientist ranks exceeding 20 percent, our research, training, and teaching portfolio was full and we graduated 93 students and published 398 manuscripts primarily focused on addressing the real conservation challenges of our cooperators. As I’ve stated before, our mission is our legacy: meeting the actionable science needs of our cooperators, providing them technical guidance and assistance in interpreting and applying new advances in science, and developing the future workforce through graduate education and mentoring. Our scientists and the manner in which they approach our mission continue to inspire me. The most rewarding part of my job is meeting and engaging with the students they recruit—the conservation professionals of the future. I cannot help but feel uplifted after discussions with and presentations by these young men and women. Personally, I owe my place in the profession today to the mentoring I received as a CRU student, and today’s CRU scientists have raised the bar. It gives me hope for the future of conservation, and added motivation to see our vacancies filled so that we can expand our portfolio.The National Cooperators’ Coalition has been active and is strategically working to build support on our behalf. Sincere thanks to the American Fisheries Society, the Association of Fish and Wildlife Agencies, the Boone and Crockett Club, the National Association of University Fish and Wildlife Programs, the Wildlife Management Institute, and The Wildlife Society for their efforts and those of their affiliated members.We co-sponsored a workshop at the 2016 North American Wildlife and Natural Resources Conference along with the American Fisheries Society, the Association of Fish and Wildlife Agencies, the Wildlife Management Institute, and The Wildlife Society, titled “Barriers and Bridges in Reconnecting Natural Resources

  20. The shift work and health research agenda: Considering changes in gut microbiota as a pathway linking shift work, sleep loss and circadian misalignment, and metabolic disease.

    Reynolds, Amy C; Paterson, Jessica L; Ferguson, Sally A; Stanley, Dragana; Wright, Kenneth P; Dawson, Drew

    2017-08-01

    Prevalence and impact of metabolic disease is rising. In particular, overweight and obesity are at epidemic levels and are a leading health concern in the Western world. Shift work increases the risk of overweight and obesity, along with a number of additional metabolic diseases, including metabolic syndrome and type 2 diabetes (T2D). How shift work contributes to metabolic disease has not been fully elucidated. Short sleep duration is associated with metabolic disease and shift workers typically have shorter sleep durations. Short sleep durations have been shown to elicit a physiological stress response, and both physiological and psychological stress disrupt the healthy functioning of the intestinal gut microbiota. Recent findings have shown altered intestinal microbial communities and dysbiosis of the gut microbiota in circadian disrupted mice and jet lagged humans. We hypothesize that sleep and circadian disruption in humans alters the gut microbiota, contributing to an inflammatory state and metabolic disease associated with shift work. A research agenda for exploring the relationship between insufficient sleep, circadian misalignment and the gut microbiota is provided. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. Status of anesthesiology resident research education in the United States: structured education programs increase resident research productivity.

    Ahmad, Shireen; De Oliveira, Gildasio S; McCarthy, Robert J

    2013-01-01

    The enhancement of resident research education has been proposed to increase the number of academic anesthesiologists with the skills and knowledge to conduct meaningful research. Program directors (PDs) of the U.S. anesthesiology residency programs were surveyed to evaluate the status of research education during residency training and to test the hypothesis that structured programs result in greater resident research productivity based on resident publications. Survey responses were solicited from 131 anesthesiology residency PDs. Seventy-four percent of PDs responded to the survey. Questions evaluated department demographic information, the extent of faculty research activity, research resources and research funding in the department, the characteristics of resident research education and resident research productivity, departmental support for resident research, and perceived barriers to resident research education. Thirty-two percent of programs had a structured resident research education program. Structured programs were more likely to be curriculum based, require resident participation in a research project, and provide specific training in presentation and writing skills. Productivity expectations were similar between structured and nonstructured programs. Forty percent of structured programs had > 20% of trainees with a publication in the last 2 years compared with 14% of departments with unstructured programs (difference, 26%; 99% confidence interval [CI], 8%-51%; P = 0.01). The percentage of programs that had research rotations for ≥2 months was not different between the structured and the nonstructured programs. A research rotation of >2 months did not increase the percentage of residents who had published an article within the last 2 months compared with a research rotation of 20% of residents with a publication in the last 2 years compared with 36% in programs with >20% of faculty involvement (difference, 21%; 99% CI, -4% to 46%; P = 0.03). Our

  2. Earth Science Research in DUSEL; a Deep Underground Science and Engineering Laboratory in the United States

    Fairhurst, C.; Onstott, T. C.; Tiedje, J. M.; McPherson, B.; Pfiffner, S. M.; Wang, J. S.

    2004-12-01

    A summary of efforts to create one or more Deep Underground Science and Engineering Laboratories (DUSEL) in the United States is presented. A workshop in Berkeley, August 11-14, 2004, explored the technical requirements of DUSEL for research in basic and applied geological and microbiological sciences, together with elementary particle physics and integrated education and public outreach. The workshop was organized by Bernard Sadoulet, an astrophysicist and the principal investigator (PI) of a community-wide DUSEL program evolving in coordination with the National Science Foundation. The PI team has three physicists (in nuclear science, high-energy physics, and astrophysics) and three earth scientists (in geoscience, biology and engineering). Presentations, working group reports, links to previous workshop/meeting talks, and information about DUSEL candidate sites, are presented in http://neutrino.lbl.gov/DUSELS-1. The Berkeley workshop is a continuation of decades of efforts, the most recent including the 2001 Underground Science Conference's earth science and geomicrobiology workshops, the 2002 International Workshop on Neutrino and Subterranean Science, and the 2003 EarthLab Report. This perspective (from three earth science co-PIs, the lead author of EarthLab report, the lead scientist of education/outreach, and the local earth science organizer) is to inform the community on the status of this national initiative, and to invite their active support. Having a dedicated facility with decades-long, extensive three-dimensional underground access was recognized as the most important single attribute of DUSEL. Many research initiatives were identified and more are expected as the broader community becomes aware of DUSEL. Working groups were organized to evaluate hydrology and coupled processes; geochemistry; rock mechanics/seismology; applications (e.g., homeland security, environment assessment, petroleum recovery, and carbon sequestration); geomicrobiology and

  3. Financing the Business. PACE Revised. Level 3. Unit 8. Research & Development Series No. 240CB8.

    Ashmore, M. Catherine; Pritz, Sandra G.

    This individualized, competency-based unit on financing businesses, the eighth of 18 modules, is on the third level of the revised Program for Acquiring Competence in Entrepreneurship (PACE). Intended for the advanced secondary and postsecondary levels and for adults wanting training or retraining, this unit, together with the other materials at…

  4. Research on the pyrolysis of hardwood in an entrained bed process development unit

    Kovac, R.J.; Gorton, C.W.; Knight, J.A.; Newman, C.J.; O' Neil, D.J. (Georgia Inst. of Tech., Atlanta, GA (United States). Research Inst.)

    1991-08-01

    An atmospheric flash pyrolysis process, the Georgia Tech Entrained Flow Pyrolysis Process, for the production of liquid biofuels from oak hardwood is described. The development of the process began with bench-scale studies and a conceptual design in the 1978--1981 timeframe. Its development and successful demonstration through research on the pyrolysis of hardwood in an entrained bed process development unit (PDU), in the period of 1982--1989, is presented. Oil yields (dry basis) up to 60% were achieved in the 1.5 ton-per-day PDU, far exceeding the initial target/forecast of 40% oil yields. Experimental data, based on over forty runs under steady-state conditions, supported by material and energy balances of near-100% closures, have been used to establish a process model which indicates that oil yields well in excess of 60% (dry basis) can be achieved in a commercial reactor. Experimental results demonstrate a gross product thermal efficiency of 94% and a net product thermal efficiency of 72% or more; the highest values yet achieved with a large-scale biomass liquefaction process. A conceptual manufacturing process and an economic analysis for liquid biofuel production at 60% oil yield from a 200-TPD commercial plant is reported. The plant appears to be profitable at contemporary fuel costs of $21/barrel oil-equivalent. Total capital investment is estimated at under $2.5 million. A rate-of-return on investment of 39.4% and a pay-out period of 2.1 years has been estimated. The manufacturing cost of the combustible pyrolysis oil is $2.70 per gigajoule. 20 figs., 87 tabs.

  5. Realising participation within an action research project on two Care Innovation Units providing care for older people.

    Drs Miranda Snoeren; MSc Donna Frost

    2011-01-01

    Background: On two Care Innovation Units in the Netherlands, staff, students and Lecturer Practitioners work intensively together to provide care, create a rich learning environment, and to foster innovation and research. In striving to advance the quality of care and to develop person centred

  6. Dental Health Services Research Unit celebrates 30 years: Report of conference to mark the 30th anniversary of the Dental Health Services Research Unit (DHSRU) at Dundee, held on 1st December 2008.

    Eaton, Kenneth A; Pitts, Nigel B

    2009-04-01

    Over the years, several members of the staff of the Dental Health Services Research Unit (DHSRU) at Dundee have published papers in Primary Dental Care. Furthermore, its Director, Professor Nigel Pitts, together with Drs Jan Clarkson and Gail Topping have co-edited a number of the Faculty of General Dental Practice (UK)'s standards manuals and contributed to others. It had been suggested to the Unit by several parties that, having been in funded existence for some 30 years, it would be appropriate to mark this anniversary with a conference to explore 'Dental Health Services Research: After 30 years, what was the impact, what have we learned and where are we going?' So, following a range of consultations, the conference was convened at the West Park Conference Centre in Dundee with a mixed audience representing both dental research and dental practice.

  7. United States Air Force Summer Faculty Research Program 1989. Program Technical Report. Volume 1

    1989-12-01

    Nebel Limb Radiances Under Sunlit Conditions in the 50-120 KM Altitude Range 61 Estimating Solar Flare Proton Fluences Dr. Hugh Nutley From 1850 with...MCD spectrum. The y axis units are, therefore, absorbance/ Tesla . The sensitivity of the apparatus was estimated to be 0.01 absorbance unit with 1000...the roof and walls, is placed. As a final step the excavated soil is used to cover the structure leaving the entrance and exit ramps open. The

  8. Research progress in roles of gut microbiota and bile acid metabolism in development and progression of NAFLD

    LU Xu

    2014-11-01

    Full Text Available With the prevalence of obesity and metabolic syndrome, the incidence of nonalcoholic fatty liver disease (NAFLD is increasing year by year. Studies have uncovered the important roles of gut microbiota and bile acid metabolism in the development and progression of NAFLD. The roles of gut microbiota, as well bile acid and bile acid receptors, in the development and progression of NAFLD are highlighted.

  9. Research and photovoltaic industry at the United States; Recherche et industrie photovoltaique (PV) aux Etats-Unis

    Lerouge, Ch; Herino, R; Delville, R; Allegre, R

    2006-06-15

    For a big country as the United States, the solar energy can be a solution for the air quality improvement, the greenhouse gases fight and the reduction of the dependence to the imported petroleum and also for the economic growth by the increase of the employment in the solar industry sector. This document takes stock on the photovoltaic in the United States in the industrial and research domains. The american photovoltaic industry is the third behind the Japan and the Germany. (A.L.B.)

  10. Basic Research about Calculation of the Decommissioning Unit Cost based on The KRR-2 Decommissioning Project

    Song, Chan-Ho; Park, Hee-Seong; Ha, Jea-Hyun; Jin, Hyung-Gon; Park, Seung-Kook

    2015-01-01

    The KAERI be used to calculate the decommissioning cost and manage the data of decommissioning activity experience through systems such as the decommissioning information management system (DECOMMIS), Decommissioning Facility Characterization DB System (DEFACS), decommissioning work-unit productivity calculation system (DEWOCS). Some country such as Japan and The United States have the information for decommissioning experience of the NPP and publish reports on decommissioning cost analysis. These reports as valuable data be used to compare with the decommissioning unit cost. In particular, need a method to estimate the decommissioning cost of the NPP because there is no decommissioning experience of NPP in case of Korea. makes possible to predict the more precise prediction about the decommissioning unit cost. But still, there are many differences on calculation for the decommissioning unit cost in domestic and foreign country. Typically, it is difficult to compare with data because published not detailed reports. Therefore, field of estimation for decommissioning cost have to use a unified framework in order to the decommissioning cost be provided to exact of the decommissioning cost

  11. Basic Research about Calculation of the Decommissioning Unit Cost based on The KRR-2 Decommissioning Project

    Song, Chan-Ho; Park, Hee-Seong; Ha, Jea-Hyun; Jin, Hyung-Gon; Park, Seung-Kook [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-05-15

    The KAERI be used to calculate the decommissioning cost and manage the data of decommissioning activity experience through systems such as the decommissioning information management system (DECOMMIS), Decommissioning Facility Characterization DB System (DEFACS), decommissioning work-unit productivity calculation system (DEWOCS). Some country such as Japan and The United States have the information for decommissioning experience of the NPP and publish reports on decommissioning cost analysis. These reports as valuable data be used to compare with the decommissioning unit cost. In particular, need a method to estimate the decommissioning cost of the NPP because there is no decommissioning experience of NPP in case of Korea. makes possible to predict the more precise prediction about the decommissioning unit cost. But still, there are many differences on calculation for the decommissioning unit cost in domestic and foreign country. Typically, it is difficult to compare with data because published not detailed reports. Therefore, field of estimation for decommissioning cost have to use a unified framework in order to the decommissioning cost be provided to exact of the decommissioning cost.

  12. The Research of Utilization Hours of Coal-Fired Power Generation Units Based on Electric Energy Balance

    Liu, Junhui; Yang, Jianlian; Wang, Jiangbo; Yang, Meng; Tian, Chunzheng; He, Xinhui

    2018-01-01

    With grid-connected scale of clean energy such as wind power and photovoltaic power expanding rapidly and cross-province transmission scale being bigger, utilization hours of coal-fired power generation units become lower and lower in the context of the current slowdown in electricity demand. This paper analyzes the influencing factors from the three aspects of demand, supply and supply and demand balance, and the mathematical model has been constructed based on the electric energy balance. The utilization hours of coal-fired power generation units have been solved considering the relationship among proportion of various types of power installed capacity, the output rate and utilization hours. By carrying out empirical research in Henan Province, the utilization hours of coal-fired units of Henan Province in 2020 has been achieved. The example validates the practicability and the rationality of the model, which can provide a basis for the decision-making for coal-fired power generation enterprises.

  13. Opening up animal research and science-society relations? A thematic analysis of transparency discourses in the United Kingdom.

    McLeod, Carmen; Hobson-West, Pru

    2016-10-01

    The use of animals in scientific research represents an interesting case to consider in the context of the contemporary preoccupation with transparency and openness in science and governance. In the United Kingdom, organisations critical of animal research have long called for more openness. More recently, organisations involved in animal research also seem to be embracing transparency discourses. This article provides a detailed analysis of publically available documents from animal protection groups, the animal research community and government/research funders. Our aim is to explore the similarities and differences in the way transparency is constructed and to identify what more openness is expected to achieve. In contrast to the existing literature, we conclude that the slipperiness of transparency discourses may ultimately have transformative implications for the relationship between science and society and that contemporary openness initiatives might be sowing the seeds for change to the status quo. © The Author(s) 2015.

  14. Developing information technology at the Medical Research Unit of the Albert Schweitzer Hospital in Lambaréné, Gabon.

    Dibacka, Paterne Lessihuin; Bounda, Yann; Nguema, Davy Ondo; Lell, Bertrand

    2010-03-01

    Information technology has become a key resource for research institutions, providing services such as hardware, software and network maintenance, as well as data management services. The IT department of the Medical Research Unit (MRU) of the Albert Schweitzer Hospital in Lambaréné, Gabon is a good example of how IT has developed at African Research Centres in recent years and demonstrates the scope of work that a modern research centre needs to offer. It illustrates the development in the past 15 years--from single computers maintained by investigators to the present situation of a group of well-trained local IT personal who are in charge of a variety of hardware and software and who also develop applications for use in a research environment. Open source applications are particularly suited for these needs and various applications are used in data management, data analysis, accounting, administration and quality management.

  15. Opening up animal research and science–society relations? A thematic analysis of transparency discourses in the United Kingdom

    McLeod, Carmen; Hobson-West, Pru

    2015-01-01

    The use of animals in scientific research represents an interesting case to consider in the context of the contemporary preoccupation with transparency and openness in science and governance. In the United Kingdom, organisations critical of animal research have long called for more openness. More recently, organisations involved in animal research also seem to be embracing transparency discourses. This article provides a detailed analysis of publically available documents from animal protection groups, the animal research community and government/research funders. Our aim is to explore the similarities and differences in the way transparency is constructed and to identify what more openness is expected to achieve. In contrast to the existing literature, we conclude that the slipperiness of transparency discourses may ultimately have transformative implications for the relationship between science and society and that contemporary openness initiatives might be sowing the seeds for change to the status quo. PMID:26009149

  16. An Assessment of Research-Doctorate Programs in the United States: Engineering.

    Jones, Lyle V., Ed.; And Others

    The quality of doctoral-level chemical engineering (N=79), civil engineering (N=74), electrical engineering (N=91), and mechanical engineering (N=82) programs at United States universities was assessed, using 16 measures. These measures focused on variables related to: (1) program size; (2) characteristics of graduates; (3) reputational factors…

  17. Magnets for fusion reactors and plasma physics research: state of the art in the United States

    Smith, G.E.

    1977-01-01

    The breadth of magnet development in the United States is covered briefly and a few of the difficult technical issues are touched on. Toroidal field coils for tokamaks and superconducting field coils for mirror devices are covered. Parameters of the magnets of various devices are tabulated

  18. Magnets for fusion reactors and plasma physics research: state of the art in the United States

    Smith, G. E.

    1977-01-01

    The breadth of magnet development in the United States is covered briefly and a few of the difficult technical issues are touched on. Toroidal field coils for tokamaks and superconducting field coils for mirror devices are covered. Parameters of the magnets of various devices are tabulated. (MHR)

  19. Priority research and management issues for the imperiled Great Basin of the western United States

    Jeanne C. Chambers; Michael J. Wisdom

    2009-01-01

    Like many arid and semiarid regions, the Great Basin of the western United States is undergoing major ecological, social, and economic changes that are having widespread detrimental effects on the structure, composition, and function of native ecosystems. The causes of change are highly interactive and include urban, suburban, and exurban growth, past and present land...

  20. Financing the Business. PACE Revised. Level 2. Unit 8. Research & Development Series No. 240BB8.

    Ashmore, M. Catherine; Pritz, Sandra G.

    This unit on financing a small business, the eighth in a series of 18 modules, is on the second level of the revised PACE (Program for Acquiring Competence in Entrepreneurship) comprehensive curriculum. Geared to advanced secondary and beginning postsecondary or adult students, the modules provide an opportunity to learn about and try out…

  1. Financing the Business. PACE Revised. Level 1. Unit 8. Research & Development Series No. 240AB8.

    Ashmore, M. Catherine; Pritz, Sandra G.

    This lesson on financing a business, the eighth in a series of 18 units, is part of the first level of a comprehensive entrepreneurship curriculum entitled: A Program for Acquiring Competence in Entrepreneurship (PACE). (Designed for use with secondary students, the first level of PACE introduces students to the concepts involved in…

  2. United States Department of Agriculture-Agricultural Research Service research programs on microbes for management of plant-parasitic nematodes.

    Meyer, Susan L F

    2003-01-01

    Restrictions on the use of conventional nematicides have increased the need for new methods of managing plant-parasitic nematodes. Consequently, nematode-antagonistic microbes, and active compounds produced by such organisms, are being explored as potential additions to management practices. Programs in this area at the USDA Agricultural Research Service investigate applied biocontrol agents, naturally occurring beneficial soil microbes and natural compounds. Specific research topics include use of plant growth-promoting rhizobacteria and cultural practices for management of root-knot and ring nematodes, determination of management strategies that enhance activity of naturally occurring Pasteuria species (bacterial obligate parasites of nematodes), studies on interactions between biocontrol bacteria and bacterial-feeding nematodes, and screening of microbes for compounds active against plant-parasitic nematodes. Some studies involve biocontrol agents that are active against nematodes and soil-borne plant-pathogenic fungi, or combinations of beneficial bacteria and fungi, to manage a spectrum of plant diseases or to increase efficacy over a broader range of environmental conditions. Effective methods or agents identified in the research programs are investigated as additions to existing management systems for plant-parasitic nematodes.

  3. The Pediatric Emergency Care Applied Research Network: a history of multicenter collaboration in the United States.

    Tzimenatos, Leah; Kim, Emily; Kuppermann, Nathan

    2015-01-01

    In this article, we review the history and progress of a large multicenter research network pertaining to emergency medical services for children. We describe the history, organization, infrastructure, and research agenda of the Pediatric Emergency Care Applied Research Network and highlight some of the important accomplishments since its inception. We also describe the network's strategy to grow its research portfolio, train new investigators, and study how to translate new evidence into practice. This strategy ensures not only the sustainability of the network in the future but the growth of research in emergency medical services for children in general.

  4. International topical meeting on research reactor fuel management (RRFM) - United States foreign research reactor (FRR) spent nuclear fuel (SNF) acceptance program: 2010 update

    Messick, C.E.; Taylor, J.L.; Niehus, M.T.; Landers, C.

    2010-01-01

    The Nuclear Weapons Nonproliferation Policy Concerning Foreign Research Reactor Spent Nuclear Fuel, adopted by the United States Department of Energy (DOE), in consultation with the Department of State (DOS) in May 1996, scheduled to expire May 12, 2016, to return research reactor fuel until May 12, 2019 to the U.S. is in its fourteenth year. This paper provides a brief update on the program, part of the National Nuclear Security Administration (NNSA), and discusses program initiatives and future activities. The goal of the program continues to be recovery of U.S.-origin nuclear materials, which could otherwise be used in weapons, while assisting other countries to enjoy the benefits of nuclear technology. The NNSA is seeking feedback from research reactor operators to help us understand ways to include eligible research reactors who have not yet participated in the program. (author)

  5. Cellular metabolism

    Hildebrand, C.E.; Walters, R.A.

    1977-01-01

    Progress is reported on the following research projects: chromatin structure; the use of circular synthetic polydeoxynucleotides as substrates for the study of DNA repair enzymes; human cellular kinetic response following exposure to DNA-interactive compounds; histone phosphorylation and chromatin structure in cell proliferation; photoaddition products induced in chromatin by uv light; pollutants and genetic information transfer; altered RNA metabolism as a function of cadmium accumulation and intracellular distribution in cultured cells; and thymidylate chromophore destruction by water free radicals

  6. Industry-funded dermatologic research within academia in the United States: fiscal and ethical considerations.

    Blank, I H

    1992-03-01

    Private-sector funding of biomedical research within academia may come from industry, foundations, the dermatologists themselves, and the public at large. Industry-funding is of benefit to both academia and industry. Industry may fund clinical and basic research and product testing. Industry is more willing to fund product testing and clinical research than basic research. Funds for dermatologic research may be obtained from manufacturers of drugs, medical devices, cosmetics, soaps, and detergents. Questions of academic freedom arise when research is funded by industry. The results of academic research are in the public domain; the results of intramural industry research are often proprietary, i.e., "trade secrets." When there is industry funding within academia, any restraints on publication should be held to a minimum and be temporary. Publication should occur in a timely fashion, although recognizing the need for delayed publication if the results concern patentable material. When there is a consultantship, pre-arranged terms of agreement may restrict communication. Patents usually are held by the investigator's institution. The funding company may be granted world-wide, royalty-bearing licenses. Conflicts of interest may arise during any research endeavor; this warrants close attention when the research is industry funded. Stock ownership, speaker fees, blind contracts, etc., should be avoided. In any communication, funding agreements should be stated. Indirect costs are a "necessary evil." There are non-research expenditures associated with all research projects for which the institution is justified in requesting compensation. Indirect costs must have definite connections to a project. As industrial funding of research within academia increases, various facets of the academia-industry relationship are receiving increasing attention. Several aspects of conflicts of interest and indirect costs must yet be resolved. When faced openly and directly, all of these

  7. United States Transuranium and Uranium Registries: Researching radiation protection. USTUR annual report for February 1, 1999 through January 31, 2000

    Ehrhart, Susan M. (ed.); Filipy, Ronald E. (ed.)

    2000-07-01

    The United States Transuranium and Uranium Registries (USTUR) comprise a human tissue research program studying the deposition, biokinetics and dosimetry of the actinide elements in humans with the primary goals of providing data fundamental to the verification, refinement, or future development of radiation protection standards for these and other radionuclides, and of determining possible bioeffects on both a macro and subcellular level attributable to exposure to the actinides. This report covers USTUR activities during the year from February 1999 through January 2000.

  8. United States Transuranium and Uranium Registries: Researching radiation protection. USTUR annual report for February 1, 1999 through January 31, 2000

    Ehrhart, Susan M.; Filipy, Ronald E.

    2000-01-01

    The United States Transuranium and Uranium Registries (USTUR) comprise a human tissue research program studying the deposition, biokinetics and dosimetry of the actinide elements in humans with the primary goals of providing data fundamental to the verification, refinement, or future development of radiation protection standards for these and other radionuclides, and of determining possible bioeffects on both a macro and subcellular level attributable to exposure to the actinides. This report covers USTUR activities during the year from February 1999 through January 2000

  9. Qualitative research within trials: developing a standard operating procedure for a clinical trials unit

    Rapport, Frances; Clement, Clare

    2013-01-01

    BackgroundQualitative research methods are increasingly used within trials to address broader research questions than quantitative methods can address alone. Qualitative methods enable health professionals, service users and other stakeholders to contribute their views and experiences when evaluating health care treatments, interventions or policies. They can influence trial design, allowing for a fuller engagement with research questions, aims and objectives and clarify the complexities of p...

  10. Report by the AERES on the unit: Unit of researches on neutron transport and radioactivity confinement in nuclear installations under the supervision of the establishments and bodies: IRSN

    2010-07-01

    This report is a kind of audit report on a research laboratory whose activity is organized in three departments: neutron transport and criticality (themes: numerical methods, maths and statistics related to the simulation of neutral particle propagation, nuclear data, uncertainty propagation and bias estimation, code qualification and associated experimental programs, neutron transport in reactors and fuel cycle, criticality accidents), radionuclide transfer in radioactive waste disposals (site identification strategy, hydro-mechanical phenomena affecting storage performance, physical-chemical evolution factors, storage modelling), and metrology and confinement of radioactive gases and aerosols. The authors discuss an assessment of the unit activities in terms of strengths and opportunities, aspects to be improved and recommendations, productions and publications. A more detailed assessment is presented for each department in terms of scientific quality, influence and attractiveness (awards, recruitment capacity, capacity to obtain financing and to tender, participation to international programs), strategy and governance, and project

  11. Progress report to United States Energy Research and Development Administration, November 1, 1976--October 31, 1977

    1977-01-01

    Progress is reported for research completed and in progress at Vanderbilt University in the following areas: in beam spectroscopy, coulomb excitation, nucleon transfer reactions, nuclear theory, radioactivity studies

  12. Beyond Bullying: Consideration of Additional Research for the Assessment and Prevention of Potential Rampage School Violence in the United States

    Evonn Welton

    2014-01-01

    Full Text Available For approximately 15 years there have been a number of episodes of rampage school violence in elementary/high school and higher education in the United States. Initial responses included implementation of antibullying programs, disciplinary measures, and increased law security measures. As the incidences have continued, it has become apparent that a more collaborative and interdisciplinary approach is needed for prevention. This paper offers a review of research literature as it applies to proposed innovative strategies for collaborative research, prevention, and intervention in the school setting.

  13. Design and implementation of the Molecular Imaging Unit for large animais at the National Center for Cardiovascular Research

    Lopez, G.; Delgado Alberquilla, R.; Moreno Lopez, J.; Escudero Toro, R.

    2011-01-01

    in this paper describes the most iraportant imaging techniques to be used with the latest equipment as well as the future of PET-MRI combination, its application in research on large animals and the implications for the design of the units, shielding calculation management, sources of radiation and waste. This has reguired value and integrate the specific requirements of a research center in terms of bio security, care of large animals (pigs), health status of animals in an environment of highly demanding conditions PR.

  14. A RESEARCH ON ACCIDENTS RISKS AND CAUSES IN THE NEONATAL INTENSIVE CARE UNITS

    Haluk Tanrıverdi

    2015-10-01

    Full Text Available This study aims to demonstrate the relationship between the qualifications of neonatal intensive care units of hospitals (physical conditions, standard applications, employee qualifications and use of personal protective equipment and work related causes and risks, employee related causes and risks when occupational accidents occur. Accordingly, a survey was prepared and was made among 105 nurses working in 3 public and 3 private hospital's neonatal intensive care units, in the January of 2010. The survey consists of questions about the qualifications of neonatal intensive care units, work related causes and risks, and employee related causes and risks. From the regression analysis conducted, it has been found that confirmed hypotheses in several studies in the literature were not significant in this study. The sub-dimensions in which relationships has been found show that the improvement of the physical environment in workplace, the improvement of the employee qualifications and standard applications can reduce the rate of occupational accidents. According to the results of this study management should take care of the organizational factors besides to improvement of the physical environment in workplace, the improvement of the employee qualifications and standard applications.

  15. Synthetic biology and metabolic engineering.

    Stephanopoulos, Gregory

    2012-11-16

    Metabolic engineering emerged 20 years ago as the discipline occupied with the directed modification of metabolic pathways for the microbial synthesis of various products. As such, it deals with the engineering (design, construction, and optimization) of native as well as non-natural routes of product synthesis, aided in this task by the availability of synthetic DNA, the core enabling technology of synthetic biology. The two fields, however, only partially overlap in their interest in pathway engineering. While fabrication of biobricks, synthetic cells, genetic circuits, and nonlinear cell dynamics, along with pathway engineering, have occupied researchers in the field of synthetic biology, the sum total of these areas does not constitute a coherent definition of synthetic biology with a distinct intellectual foundation and well-defined areas of application. This paper reviews the origins of the two fields and advances two distinct paradigms for each of them: that of unit operations for metabolic engineering and electronic circuits for synthetic biology. In this context, metabolic engineering is about engineering cell factories for the biological manufacturing of chemical and pharmaceutical products, whereas the main focus of synthetic biology is fundamental biological research facilitated by the use of synthetic DNA and genetic circuits.

  16. Maximising value from a United Kingdom Biomedical Research Centre: study protocol.

    Greenhalgh, Trisha; Ovseiko, Pavel V; Fahy, Nick; Shaw, Sara; Kerr, Polly; Rushforth, Alexander D; Channon, Keith M; Kiparoglou, Vasiliki

    2017-08-14

    Biomedical Research Centres (BRCs) are partnerships between healthcare organisations and universities in England. Their mission is to generate novel treatments, technologies, diagnostics and other interventions that increase the country's international competitiveness, to rapidly translate these innovations into benefits for patients, and to improve efficiency and reduce waste in healthcare. As NIHR Oxford BRC (Oxford BRC) enters its third 5-year funding period, we seek to (1) apply the evidence base on how best to support the various partnerships in this large, multi-stakeholder research system and (2) research how these partnerships play out in a new, ambitious programme of translational research. Organisational case study, informed by the principles of action research. A cross-cutting theme, 'Partnerships for Health, Wealth and Innovation' has been established with multiple sub-themes (drug development, device development, business support and commercialisation, research methodology and statistics, health economics, bioethics, patient and public involvement and engagement, knowledge translation, and education and training) to support individual BRC research themes and generate cross-theme learning. The 'Partnerships' theme will support the BRC's goals by facilitating six types of partnership (with patients and citizens, clinical services, industry, across the NIHR infrastructure, across academic disciplines, and with policymakers and payers) through a range of engagement platforms and activities. We will develop a longitudinal progress narrative centred around exemplar case studies, and apply theoretical models from innovation studies (Triple Helix), sociology of science (Mode 2 knowledge production) and business studies (Value Co-creation). Data sources will be the empirical research studies within individual BRC research themes (who will apply separately for NHS ethics approval), plus documentary analysis and interviews and ethnography with research

  17. Turning health research into health promotion: a study of causality and 'critical insights' in a United Kingdom health campaign.

    Piggin, Joe

    2012-10-01

    This article examines how important decisions about health can alter between public health policy formulation and eventual marketing implementation. Specifically, the article traces the development and production of a major United Kingdom social marketing campaign named Change4Life, and examines how ideas about the causes of and solutions to the obesity epidemic are produced in differing ways throughout the health promotion process. This study examines a variety of United Kingdom health research, policy, marketing strategy and marketing messages between 2008 and 2011. This research demonstrates that claims about causality oscillate and alter throughout the research, policy and Change4Life marketing process. These oscillations are problematic, since the Department of Health described the original consumer research as 'critical'. Given both the importance of the health issues being addressed and the amount of funding dedicated to Change4Life, that 'critical' research was directly contradicted in the campaign requires urgent review. To conclude, the article discusses the utility of social marketing when considering causal claims in health promotion. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  18. United States Geological Survey uranium and thorium resource assessment and exploration research program, fiscal year 1980

    Offield, T.W.

    1979-01-01

    Research is being conducted by the USGS for the NURE program in six fields: geochemistry and mineralogy, sedimentary environments, igneous and metamorphic environments, geophysical exploration techniques, U resource assessment, and Th resource assessment. Some FY 1979 research results are reported and discussed

  19. A Resurgence of United Kingdom Nuclear Power Research (2011 EFRC Forum)

    Grimes, Robin W.

    2011-01-01

    Robin W. Grimes, Professor at Imperial College, London, was the third speaker in the May 26, 2011 EFRC Forum session, 'Global Perspectives on Frontiers in Energy Research.' In his presentation, Professor Grimes discussed recent research endeavors in advanced nuclear energy systems being pursued in the UK. The 2011 EFRC Summit and Forum brought together the EFRC community and science and policy leaders from universities, national laboratories, industry and government to discuss 'Science for our Nation's Energy Future.' In August 2009, the Office of Science established 46 Energy Frontier Research Centers. The EFRCs are collaborative research efforts intended to accelerate high-risk, high-reward fundamental research, the scientific basis for transformative energy technologies of the future. These Centers involve universities, national laboratories, nonprofit organizations, and for-profit firms, singly or in partnerships, selected by scientific peer review. They are funded at $2 to $5 million per year for a total planned DOE commitment of $777 million over the initial five-year award period, pending Congressional appropriations. These integrated, multi-investigator Centers are conducting fundamental research focusing on one or more of several 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The purpose of the EFRCs is to integrate the talents and expertise of leading scientists in a setting designed to accelerate research that transforms the future of energy and the environment.

  20. Foreign-Born Women Faculty Work Roles and Productivity at Research Universities in the United States

    Mamiseishvili, Ketevan

    2010-01-01

    Using the data from the 2004 National Study of Postsecondary Faculty (NSOPF:04) survey, the study examined foreign-born women faculty members' work roles and productivity in the areas of teaching, research, and service in comparison with their US-born counterparts at research universities in the US. The findings provided some evidence to suggest…

  1. Moving from a Predominantly Teaching Oriented Culture to a Research Productivity Mission: The Case of Mexico and the United States

    Gustavo Gregorutti

    2010-12-01

    Full Text Available This study qualitatively analyzes the culture conflicts professors in the United States and Mexico are experiencing with the increasing pressures to produce more research about higher education. The first dataset was collected from 36 faculty members from 12 small and medium sized private, doctorate-granting universities. These universities are located in 11 states across the United States. The remaining data came from 44 faculty members employed at four small and medium sized private, doctoral granting universities in four states across Mexico. Results showed that universities in the US are transitioning from a predominantly teaching college culture to a more research orientation. Although the sampled universities continue to offer established graduate programs, faculty members continue to struggle with their teaching requirements and conflicts research productivity pressures place on their teaching and mentoring time with students. Participating faculty members employed in the US were not evenly interested in research opportunities due to the diverse mission objectives promoted by their respective institutions. On the other hand, faculty members employed in Mexico were generally more concerned with their research productivity and subsequent factors, which negatively impact their research productivity. Mexican faculty members rarely cited conflicts between their institutional missions and teaching objectives. This study is highly relevant to policy makers, higher education administrators, and scholars interested in comparative and international higher education. Administrators can benefit from the findings in this study, which provides faculty members’ perceptions and describes departmental structures and organizational dynamics employed to advance greater research and development opportunities. This study concludes with a discussion on how administrators and faculty members should handle the pressures for research productivity and

  2. Survived so what? Identifying priorities for research with children and families post-paediatric intensive care unit.

    Manning, Joseph C; Hemingway, Pippa; Redsell, Sarah A

    2018-03-01

    The involvement of patients and the public in the development, implementation and evaluation of health care services and research is recognized to have tangible benefits in relation to effectiveness and credibility. However, despite >96% of children and young people surviving critical illness or injury, there is a paucity of published reports demonstrating their contribution to informing the priorities for aftercare services and outcomes research. We aimed to identify the service and research priorities for Paediatric Intensive Care Unit survivors with children and young people, their families and other stakeholders. We conducted a face-to-face, multiple-stakeholder consultation event, held in the Midlands (UK), to provide opportunities for experiences, views and priorities to be elicited. Data were gathered using write/draw and tell and focus group approaches. An inductive content analytical approach was used to categorize and conceptualize feedback. A total of 26 individuals attended the consultation exercise, including children and young people who were critical care survivors; their siblings; parents and carers; health professionals; academics; commissioners; and service managers. Consultation findings indicated that future services, interventions and research must be holistic and family-centred. Children and young people advisors reported priorities that focused on longer-term outcomes, whereas adult advisors identified priorities that mapped against the pathways of care. Specific priorities included developing and testing interventions that address unmet communication and information needs. Furthermore, initiatives to optimize the lives and longer-term functional and psycho-social outcomes of Paediatric Intensive Care Unit survivors were identified. This consultation exercise provides further evidence of the value of meaningful patient and public involvement in identifying the priorities for research and services for Paediatric Intensive Care Unit survivors

  3. Validation of the "United Registries for Clinical Assessment and Research" (UR-CARE), a European online registry for clinical care and research in Inflammatory Bowel Disease

    Burisch, Johan; Gisbert, Javier P; Siegmund, Britta

    2018-01-01

    Background: The "United Registries for Clinical Assessment and Research" (UR-CARE) database is an initiative of the European Crohn's and Colitis Organisation (ECCO) to facilitate daily patient care and research studies in inflammatory bowel disease (IBD). Herein, we sought to validate the database......-99%); Case 5: 91% (87-93%)]. These numbers did not differ significantly from those found 6 weeks later (NcNemar's test p>0.05). Conclusion: The UR-CARE database appears to be feasible, valid and reliable as a tool and easy to use regardless of prior user experience and level of clinical IBD experience. UR......-CARE has the potential to enhance future European collaborations regarding clinical research in IBD....

  4. Health and medical research funding agencies' promotion of public engagement within research: a qualitative interview study exploring the United Kingdom context.

    van Bekkum, Jennifer E; Fergie, Gillian M; Hilton, Shona

    2016-03-24

    Public engagement (PE) has become a common feature of many liberal governmental agendas worldwide. Since the turn of this century there has been a succession of United Kingdom policy initiatives to encourage research funding agencies, universities and researchers to reconsider how they engage with citizens and communities. Although most funding agencies now explicitly promote PE within research, little empirical work has been carried out in this area. In this study, we explored why and how health and medical research funding agencies in the United Kingdom have interpreted and implemented their role to promote PE within research. Semi-structured interviews were carried out with 30 key informants from 10 agencies that fund health or medical research. Data were also gathered from agencies' websites and documentation. The analysis was based on the constant comparative method. Across agencies, we found that PE was being interpreted and operationalised in various different ways. The terminology used within funding agencies to describe PE seems to be flexibly applied. Disciplinary differences were evident both in the terminology used to describe PE and the drivers for PE highlighted by participants - with applied health science funders more aligned with participatory models of PE. Within the grant funding process PE was rarely systematically treated as a key component of research. In particular, PE was not routinely incorporated into the planning of funding calls. PE was more likely to be considered in the application and assessment phases, where it was largely appraised as a tool for enhancing science. Concerns were expressed regarding how to monitor and evaluate PE within research. This study suggests funding agencies working within specific areas of health and medicine can promote particular definitions of PE and aligned practices which determine the boundaries in which researchers working in these areas understand and practice PE. Our study also highlights how the

  5. Thematic review series: patient-oriented research. What we have learned about VLDL and LDL metabolism from human kinetics studies.

    Parhofer, Klaus G; Barrett, P Hugh R

    2006-08-01

    Lipoprotein metabolism is the result of a complex network of many individual components. Abnormal lipoprotein concentrations can result from changes in the production, conversion, or catabolism of lipoprotein particles. Studies in hypolipoproteinemia and hyperlipoproteinemia have elucidated the processes that control VLDL secretion as well as VLDL and LDL catabolism. Here, we review the current knowledge regarding apolipoprotein B (apoB) metabolism, focusing on selected clinically relevant conditions. In hypobetalipoproteinemia attributable to truncations in apoB, the rate of secretion is closely linked to the length of apoB. On the other hand, in patients with the metabolic syndrome, it appears that substrate, in the form of free fatty acids, coupled to the state of insulin resistance can induce hypersecretion of VLDL-apoB. Studies in patients with familial hypercholesterolemia, familial defective apoB, and mutant forms of proprotein convertase subtilisin/kexin type 9 show that mutations in the LDL receptor, the ligand for the receptor, or an intracellular chaperone for the receptor are the most important determinants in regulating LDL catabolism. This review also demonstrates the variance of results within similar, or even the same, phenotypic conditions. This underscores the sensitivity of metabolic studies to methodological aspects and thus the importance of the inclusion of adequate controls in studies.

  6. Operational experience of decommissioning techniques for research reactors in the United Kingdom

    England, M.R.; McCool, T.M.

    2002-01-01

    In previous co-ordinated research projects (CRP) conducted by the IAEA no distinction was made between decommissioning activities carried out at nuclear power plants, research reactors or nuclear fuel cycle facilities. As experience was gained and technology advanced it became clear that decommissioning of research reactors had certain specific characteristics which needed a dedicated approach. It was within this context that a CRP on Decommissioning Techniques for Research Reactors was launched and conducted by the IAEA from 1997 to 2001. This paper considers the experience gained from the decommissioning of two research reactors during the course of the CRP namely: (a) the ICI Triga Mk I reactor at Billingham UK which was largely complete by the end of the research project and (b) the Argonaut 100 reactor at the Scottish Universities Research and Reactor centre at East Kilbride in Scotland which is currently is the early stages of dismantling/site operations. It is the intention of this paper with reference to the two case studies outlined above to compare the actual implementation of these works against the original proposals and identify areas that were found to be problematical and/or identify any lessons learnt. (author)

  7. Altered metabolism in cancer

    Locasale Jason W

    2010-06-01

    Full Text Available Abstract Cancer cells have different metabolic requirements from their normal counterparts. Understanding the consequences of this differential metabolism requires a detailed understanding of glucose metabolism and its relation to energy production in cancer cells. A recent study in BMC Systems Biology by Vasquez et al. developed a mathematical model to assess some features of this altered metabolism. Here, we take a broader look at the regulation of energy metabolism in cancer cells, considering their anabolic as well as catabolic needs. See research article: http://www.biomedcentral.com/1752-0509/4/58/

  8. Stroke care: Experiences and clinical research in stroke units in Chennai

    Gobindram Arjundas

    2006-01-01

    Full Text Available Background: S troke is the second commonest cause of death in India with crude overall prevalence rate of 220 per 100,000. With an increasing aging population at risk, the stroke burden in India can be expected to reach epidemic proportions. Materials and Methods: The first protocol-based prospective studies, funded by private agencies was conducted in Madras Institute of Neurology in 1984-86. The results led to establishment of the first stroke unit in Tamil Nadu state, in the institute. The first all-India hospital-based studies in acute stroke was completed as INDIAN COOPERATIVE ACUTE STROKE STUDIES (ICASS I and ICASS II with WHO STEP ONE by members of the Indian Stroke Association between 2000-2005. This has generated very useful data for our country. Results: Mortality in 1984-86 was 40%. Stroke unit in the institute dropped it to 12%. About 10 years later, ICASS studies showed a further fall of mortality to 8%, which is the current international figure in the west. Morbidity pattern showed about half return to their original activities. But about one third are left totally disabled needing prolonged care, for which fiscal, social and rehab provisions have to be done on a national basis. Conclusions: The progress and success of care of Stroke in the last three decades, from treatment in medical and neurology wards to specialized stroke units is presented. The main risk factors are hypertension, diabetes and ischemic heart disease across the country. Hypertension alone or with the other two diseases was present in 72% of cases. Prevention and treatment of these factors will reduce the stroke burden, mortality and morbidity of strokes. The Stroke-team concept can be extended to the smallest hospitals in our country.

  9. The rise of pathophysiologic research in the United States: the role of two Harvard hospitals.

    Tishler, Peter V

    2013-01-01

    Pathophysiologic research, the major approach to understanding and treating disease, was created in the 20th century, and two Harvard-affiliated hospitals, the Peter Bent Brigham Hospital and Boston City Hospital, played a key role in its development. After the Flexner Report of 1910, medical students were assigned clinical clerkships in teaching hospitals. Rockefeller-trained Francis Weld Peabody, who was committed to investigative, pathophysiologic research, was a critical leader in these efforts. At the Brigham, Harvard medical students observed patients closely and asked provocative questions about their diseases. Additionally, physicians returned from World War I with questions concerning the pathophysiology of wartime injuries. At the Boston City Hospital's new Thorndike Memorial Laboratory, Peabody fostered investigative question-based research by physicians. These physicians expanded pathophysiologic investigation from the 1920s. Post-war, Watson and Crick's formulation of the structure of DNA led shortly to modern molecular biology and new research approaches that are being furthered at the Boston Hospitals.

  10. United States of America. Report 7 [Marine Radioecology. Current Research and Future Scope

    Townsley, S.J.

    1967-01-01

    Present research programme (long-term): Interrelationship of environmental salt concentration and concentration of dissolved radionuclides to the rate of accumulation of these nuclides by euryhaline teleosts. Objectives of this research are designed toward the definition of a function that will adequately described the rate of accumulation of selected radionuclides by euryhaline teleosts from littoral or estuarine environments. Concurrent studies are being made to determine the maximum concentration accumulated by these fish under conditions of chronic exposure to selected concentrations in the medium

  11. United States Air Force Summer Faculty Research Program (1986). Program Technical Report. Volume 2

    1986-12-01

    Villa- nueva bone stain for 48 hours. After staining the sections were cleaned in tap water, lightly sanded (600 grit wet/dry paper), washed and...research collaborator. 92-2 I. INTRODUCTION 5 I have been a microbiologist since 1957. I have done research on bacteria , yeasts and filamentous fungi, and...C. Tests for Bacterial Contamination. To determine if bacteria were contaminating the algal cultures, 0.1 ml of algal material was aseptically

  12. Survey on astrobiology research and teaching activities within the United kingdom.

    Dartnell, Lewis R; Burchell, Mark J

    2009-10-01

    While astrobiology is apparently growing steadily around the world, in terms of the number of researchers drawn into this interdisciplinary area and teaching courses provided for new students, there have been very few studies conducted to chart this expansion quantitatively. To address this deficiency, the Astrobiology Society of Britain (ASB) conducted a questionnaire survey of universities and research institutions nationwide to ascertain the current extent of astrobiology research and teaching in the UK. The aim was to provide compiled statistics and an information resource for those who seek research groups or courses of study, and to facilitate new interdisciplinary collaborations. The report here summarizes details gathered on 33 UK research groups, which involved 286 researchers (from undergraduate project students to faculty members). The survey indicates that around 880 students are taking university-level courses, with significant elements of astrobiology included, every year in the UK. Data are also presented on the composition of astrobiology students by their original academic field, which show a significant dominance of physics and astronomy students. This survey represents the first published systematic national assessment of astrobiological academic activity and indicates that this emerging field has already achieved a strong degree of penetration into the UK academic community.

  13. Metabolic Syndrome

    Sevil Ikinci

    2010-10-01

    Full Text Available Metabolic Syndrome is a combination of risk factors including common etiopathogenesis. These risk factors play different roles in occurence of atherosclerotic diseases, type 2 diabetes, and cancers. Although a compromise can not be achieved on differential diagnosis for MS, the existence of any three criterias enable to diagnose MS. These are abdominal obesity, dislipidemia (hypertrigliceridemia, hypercholesterolemia, and reduced high density lipoprotein hypertension, and elevated fasting blood glucose. According to the results of Metabolic Syndrome Research (METSAR, the overall prevalence of MS in Turkey is 34%; in females 40%, and in males it is 28%. As a result of “Western” diet, and increased frequency of obesity, MS is observed in children and in adolescents both in the world and in Turkey. Resulting in chronic diseases, it is thought that the syndrome can be prevented by healthy lifestyle behaviours. [TAF Prev Med Bull 2010; 9(5.000: 535-540

  14. Annual progress report 1993. Work in controlled thermonuclear fusion research performed in the fusion research unit under the contract of association between Euratom and Risoe National Laboratory

    1994-09-01

    The programme of the Research Unit of the Fusion Association Euratom-Risoe National Laboratory covers work in fusion plasma physics and in fusion technology. The fusion plasma physics group has activities within (a) studies of nonlinear dynamical processes in magnetized plasmas, (b) development of pellet injectors for fusion experiments, and (c) development of diagnostics for fusion plasmas. The activities in technology cover radiation damage of fusion reactor materials. A summary of the activities in 1993 is presented. (au) (4 tabs., 21 ills., 64 refs.)

  15. Quantifying the economic impact of government and charity funding of medical research on private research and development funding in the United Kingdom.

    Sussex, Jon; Feng, Yan; Mestre-Ferrandiz, Jorge; Pistollato, Michele; Hafner, Marco; Burridge, Peter; Grant, Jonathan

    2016-02-24

    Government- and charity-funded medical research and private sector research and development (R&D) are widely held to be complements. The only attempts to measure this complementarity so far have used data from the United States of America and are inevitably increasingly out of date. This study estimates the magnitude of the effect of government and charity biomedical and health research expenditure in the United Kingdom (UK), separately and in total, on subsequent private pharmaceutical sector R&D expenditure in the UK. The results for this study are obtained by fitting an econometric vector error correction model (VECM) to time series for biomedical and health R&D expenditure in the UK for ten disease areas (including 'other') for the government, charity and private sectors. The VECM model describes the relationship between public (i.e. government and charities combined) sector expenditure, private sector expenditure and global pharmaceutical sales as a combination of a long-term equilibrium and short-term movements. There is a statistically significant complementary relationship between public biomedical and health research expenditure and private pharmaceutical R&D expenditure. A 1% increase in public sector expenditure is associated in the best-fit model with a 0.81% increase in private sector expenditure. Sensitivity analysis produces a similar and statistically significant result with a slightly smaller positive elasticity of 0.68. Overall, every additional £1 of public research expenditure is associated with an additional £0.83-£1.07 of private sector R&D spend in the UK; 44% of that additional private sector expenditure occurs within 1 year, with the remainder accumulating over decades. This spillover effect implies a real annual rate of return (in terms of economic impact) to public biomedical and health research in the UK of 15-18%. When combined with previous estimates of the health gain that results from public medical research in cancer and

  16. Hazardous-waste landfill research, US EPA (United States Environmental Protection Agency) program

    Schomaker, N.B.

    1988-08-01

    The Land Pollution Control Division (LPCD), Hazardous Waste Engineering Research Lab. (HWERL), U.S. Environmental Protection Agency, in Cincinnati, Ohio, has responsibility for research in solid- and hazardous-waste management with respect to land disposal of wastes. To fulfill the responsibility, the LPCD is developing concepts and is documenting the environmental effects of various waste-disposal practices; and is collecting data necessary to support implementation of disposal guidelines mandated by the Hazardous and Solid Waste Amendments of 1984 (HSWA). This paper presents an overview of the land-disposal research associated with the LPCD hazardous waste program plan and will report the current status of work in the following categorical areas: Hazardous-waste facilities - landfills and surface impoundments; Non-Hazardous waste facilities; and Technology transfer.

  17. Analyses of the transportation of spent research reactor fuel in the United States

    Cashwell, J.W.; Neuhauser, K.S.

    1989-01-01

    The Transportation Technology Center at Sandia National Laboratories has analyzed the impacts of transportation of research reactor spent fuel from US and foreign reactors for the US Department of Energy (DOE) Office of Defense Programs. This effort represents the first comprehensive analytical evaluation of the risks of transporting high-, medium-, and low-enriched uranium spent research reactor fuel by both sea and land. Two separate shipment programs have been analyzed: the shipment of research reactor spent fuel from Taiwan to the US (Fuel Movement Program), and the return of research reactor spent fuels of US origin from foreign and domestic reactors (Research Reactor Fuel Return Program). In order to perform these analyses, a comprehensive methodology for analyzing the probabilities and consequences of transportation in coastal waters and port facilities, handling at the port, and shipment by truck to reprocessing facilities was developed. The Taiwanese fuel consists of low-burnup aluminum-clad metallic uranium research reactor spent fuel; the other fuels are primarily aluminum-clad oxide fuels. The Fuel Movement Program is ongoing, while the Fuel Return Program addresses future shipments over a ten-year period. The operational aspects of the Taiwanese shipments have been uniform, but several possible shipping configurations are possible for the Fuel Return Program shipments. Comprehensive assessments, which bound the impacts of spent fuel transport, demonstrate that when shipments are made in compliance with applicable regulations, the risks for all such transport are low. For comparison with previously licensed transport activities and to provide continuity with earlier analyses, the results for shipment of 150-day-old commercial pressurized water reactor (PWR) spent fuel are presented as part of this study

  18. Reliability research based experience with systems and events at the Kozloduy NPP units 1-4

    Khristova, R; Kaltchev, B; Dimitrov, B [Energoproekt, Sofia (Bulgaria); Nedyalkova, D; Sonev, A [Kombinat Atomna Energetika, Kozloduj (Bulgaria)

    1996-12-31

    An overview of equipment reliability based on operational data of selected safety systems at the Kozloduy NPP is presented. Conclusions are drawn on reliability of the service water system, feed water system, emergency power supply - category 2, emergency high pressure ejection system and spray system. For the units 1-4 all recorded accident protocols in the period 1974-1993 have been processed and the main initiators identified. A list with 39 most frequent initiators of accidents/incidents is compiled. The human-caused errors account for 27% of all events. The reliability characteristics and frequencies have been calculated for all initiating events. It is concluded that there have not been any accidents with consequences for fuel integrity or radioactive release. 14 refs.

  19. The regulatory process, nuclear safety research and the fuel cycle in the United Kingdom

    Watson, P.

    1996-01-01

    The main legislation governing the safety of nuclear installations in the United Kingdom is the Health and Safety at Work Act 1974 (HSWA) and the associated relevant statutory provisions of the Nuclear Installations Act 1965 (as amended). The HSWA sought to simplify and unify all industrial safety legislation and set in place the Health and Safety Commission (HSC) and its executive arm, the Health and Safety Executive (HSE). The Health and Safety Executive's Nuclear Safety Division (NSD) regulates the nuclear activities on such sites through HM Nuclear Installations Inspectorate (NII). Under the Nuclear Installations Act (NIA) no corporate body may use any site for the purpose of installing or operating any reactor, other than such a reactor comprised in a means of transport, or other prescribed installation unless the operator has been granted a nuclear site licence by the Health and Safety Executive. Nuclear fuel cycle facilities are examples of such prescribed installations. (J.P.N.)

  20. Reliability research based experience with systems and events at the Kozloduy NPP units 1-4

    Khristova, R.; Kaltchev, B.; Dimitrov, B.; Nedyalkova, D.; Sonev, A.

    1995-01-01

    An overview of equipment reliability based on operational data of selected safety systems at the Kozloduy NPP is presented. Conclusions are drawn on reliability of the service water system, feed water system, emergency power supply - category 2, emergency high pressure ejection system and spray system. For the units 1-4 all recorded accident protocols in the period 1974-1993 have been processed and the main initiators identified. A list with 39 most frequent initiators of accidents/incidents is compiled. The human-caused errors account for 27% of all events. The reliability characteristics and frequencies have been calculated for all initiating events. It is concluded that there have not been any accidents with consequences for fuel integrity or radioactive release. 14 refs

  1. Evaluation and benchmarking of an EC-QCL-based mid-infrared spectrometer for monitoring metabolic blood parameters in critical care units

    Grafen, M.; Delbeck, S.; Busch, H.; Heise, H. M.; Ostendorf, A.

    2018-02-01

    Mid-infrared spectroscopy hyphenated with micro-dialysis is an excellent method for monitoring metabolic blood parameters as it enables the concurrent, reagent-free and precise measurement of multiple clinically relevant substances such as glucose, lactate and urea in micro-dialysates of blood or interstitial fluid. For a marketable implementation, quantum cascade lasers (QCL) seem to represent a favourable technology due to their high degree of miniaturization and potentially low production costs. In this work, an external cavity (EC) - QCL-based spectrometer and two Fourier-transform infrared (FTIR) spectrometers were benchmarked with regard to the precision, accuracy and long-term stability needed for the monitoring of critically ill patients. For the tests, ternary aqueous solutions of glucose, lactate and mannitol (the latter for dialysis recovery determination) were measured in custom-made flow-through transmission cells of different pathlengths and analyzed by Partial Least Squares calibration models. It was revealed, that the wavenumber tuning speed of the QCL had a severe impact on the EC-mirror trajectory due to matching the digital-analog-converter step frequency with the mechanical resonance frequency of the mirror actuation. By selecting an appropriate tuning speed, the mirror oscillations acted as a hardware smoothing filter for the significant intensity variations caused by mode hopping. Besides the tuning speed, the effects of averaging over multiple spectra and software smoothing parameters (Savitzky-Golay-filters and FT-smoothing) were investigated. The final settings led to a performance of the QCL-system, which was comparable with a research FTIR-spectrometer and even surpassed the performance of a small FTIR-mini-spectrometer.

  2. Communication barriers to applying federal research in support of land management in the United States

    Vita Wright

    2007-01-01

    Barriers to effective communication between researchers and managers can ultimately result in barriers to the application of scientific knowledge and technology for land management. Both individual and organizational barriers are important in terms of how they affect the first three stages of the innovation-decision process: 1) knowledge, where an individual is exposed...

  3. A History of Geothermal Energy Research and Development in the United States. Drilling 1976-2006

    none,

    2010-09-01

    This report, the second in a four-part series, summarizes significant research projects performed by the U.S. Department of Energy (DOE) over 30 years to overcome challenges in drilling and to make generation of electricity from geothermal resources more cost-competitive.

  4. A History of Geothermal Energy Research and Development in the United States. Exploration 1976-2006

    none,

    2010-09-01

    This report, the first in a four-part series, summarizes significant research projects performed by the U.S. Department of Energy (DOE) over 30 years to overcome challenges in exploration and to make generation of electricity from geothermal resources more cost-competitive.

  5. Innovation and change in a rehabilitation unit for the elderly : Through action research

    Hoogwerf, Lucienne Josepha Rosalia

    2002-01-01

    This report describes an eighteen-month action research project in an assessment, treatment and rehabilitation ward for older people in a large metropolitan hospital in New Zealand. The study aimed at developing participative care and the clinical nurse consultant role, and advancing nursing

  6. Learning to Become Graduate Students: Japanese Women's Experience in the Research Unit in Engineering

    Hosaka, Masako

    2010-01-01

    Based on the analysis of 16 interviews with women first-year master's students at two national engineering schools in Japan, this article examines the socialisation role of compulsory undergraduate research experience in Japanese women's decisions to pursue graduate education and choices of the programme. The findings suggest that research…

  7. United States-Latin America Cancer Research Network (US-LA CRN)

    The US–LA CRN was established in 2009 to increase cancer research capacity in Latin America. NCI formalized bilateral agreements with the governments of Argentina, Brazil, Chile, Colombia, Mexico, Peru, Puerto Rico, and Uruguay, to facilitate interactions at the government, institution, and investigator levels.

  8. Census of Institutional Repositories in the United States: MIRACLE Project Research Findings. CLIR Publication No. 140

    Markey, Karen; Rieh, Soo Young; St. Jean, Beth; Kim, Jihyun; Yakel, Elizabeth

    2007-01-01

    In this report, the authors describe results of a nationwide census of institutional repositories in U.S. academic institutions. The census is one of several activities of the MIRACLE Project, an Institute of Museum and Library Services (IMLS)-funded research program based at the University of Michigan. The acronym MIRACLE means "Making…

  9. United States of America. Report 8 [Marine Radioecology. Current Research and Future Scope

    Foster, R.F.

    1967-01-01

    Present research programme: Occurrence of radioactive materials in the environment with emphasis on potential exposure to people. A wide variety of substances that are most apt to transmit: radionuclides to man are (or have been) sampled and analysed. On the basis of these data, human intake of individual nuclides is estimated and the result transformed into estimates of dose

  10. Action Research as Professional Development: Its Role in Education Reform in the United Arab Emirates

    Hathorn, Conley; Dillon, Anna Marie

    2018-01-01

    This paper is concerned with exploring the microsystem of teachers' experiences with education reform within the action research (AR) model for professional development (PD). Within the macrosystem of current major education reform in the UAE, it is timely to explore teachers' experiences of AR as PD to improve pedagogy. The process of engaging in…

  11. Urban forestry research in the United State: the state of art and future prospects

    John F. Dwyer; David J. Nowak; Gary W. Watson

    2001-01-01

    The proceedings include 15 papers presented during four group sessions at the IUFRO XXI World Congress held in Kuala Lumpur, Malaysia during August 2000. Six papers were presented during two sessions organized by IUFRO Research Group (RG) 6.01.00 'Forest recreation, landscape and nature conservation'. The first of session was titled 'Integration of...

  12. United States Geological Survey: uranium and thorium resource assessment and exploration research program, fiscal year 1979

    Offield, T.W.

    1978-01-01

    Objectives and current plans are given for the following projects: uranium geochemistry and mineralogy; uranium in sedimentary environments; uranium in igneous and metamorphic environments; geophysical techniques in uranium and thorium exploration; and thorium investigations and resource assessment. Selected noteworthy results of FY 1978 research are given

  13. United Kingdom. Report 3 [Marine Radioecology. Current Research and Future Scope

    Preston, A.

    1967-01-01

    Present research programmes: There are two current programmes, one in the Irish Sea (fission product distribution in coastal water environments) and one in the Blackwater Estuary - North Sea (effects of discharge of neutron activation radionuclides, e.g, 65 Zn, 51 Cr, 60 Co, 54 Mn, on an estuarine environment)

  14. Analyses of the transportation of spent research reactor fuel in the United States

    Cashwell, J.W.; Neuhauser, K.S.

    1989-01-01

    We analyzed the impacts of transportation of research reactor spent fuel from US and foreign reactors for the US Department of Energy's (DOE) Office of Defense Programs. Two separate shipment programs were analyzed. The shipment of research reactor spent fuel from Taiwan to the US (Fuel Movement Program), and the return of research reactor spent fuels of US origin from foreign and domestic reactors (Research Reactor Fuel Return Program). To perform these analyses, a comprehensive methodology for analyzing the probabilities and consequences of transportation in coastal waters and port facilities, handling at the port, and shipment by truck to reprocessing facilities was developed. The Taiwanese fuel consists of low-burnup aluminum-clad metallic uranium research reactor spent fuel; the other fuels are primarily aluminum-clad oxide fuels. The Fuel Movement Program is ongoing, while the Fuel Return Program addresses future shipments over a ten-year period. The operational aspects of the Taiwanese shipments have been uniform, but several possible shipping configurations are possible for the Fuel Return Program shipments. The risks of transporting spent nuclear fuel and other radioactive materials by all modes have been analyzed extensively. Comprehensive assessments, which bound the impacts of spent fuel transport, demonstrate that when shipments are made in compliance with applicable regulations, the risks for all such transport are low. For comparison with previously licensed transport activities and to provide continuity with earlier analyses, the results for shipment of 150-day-old commercial pressurized water reactor (PWR) spent fuel are presented as part of this study

  15. Opportunities and Challenges in Establishing a Cohort Study: An Example From Cleft Lip/Palate Research in the United Kingdom.

    Stock, Nicola Marie; Humphries, Kerry; Pourcain, Beate St; Bailey, Maggie; Persson, Martin; Ho, Karen M; Ring, Susan; Marsh, Cathy; Albery, Liz; Rumsey, Nichola; Sandy, Jonathan

    2016-05-01

    Cleft lip and/or palate (CL/P) is one of the most common birth conditions in the world, but little is known about its causes. Professional opinion remains divided as to which treatments may be the most beneficial for patients with CL/P, and the factors that contribute to psychological adjustment are poorly understood. The use of different methodological approaches and tools plays a key role in hampering efforts to address discrepancies within the evidence base. A new UK-wide program of research, The Cleft Collective, was established to combat many of these methodological challenges and to address some of the key research questions important to all CL/P stakeholders. To describe the establishment of CL/P cohort studies in the United Kingdom and to consider the many opportunities this resource will generate. To date, protocols have been developed and implemented within most UK cleft teams. Biological samples, environmental information, and data pertaining to parental psychological well-being and child development are being collected successfully. Recruitment is currently on track to meet the ambitious target of approximately 9800 individuals from just more than 3000 families. The Cleft Collective cohort studies represent a significant step forward for research in the field of CL/P. The data collected will form a comprehensive resource of information about individuals with CL/P and their families. This resource will provide the basis for many future projects and collaborations, both in the United Kingdom and around the world.

  16. Luminescent unit computerization to research spectral characteristics of fine film alkali halide crystal

    Zhalimbetov, T.; Zhabetov, A.; Moldagaliev, A.; Sarmukhanov, E.; Shunkeev, K.; Shunkeev, S.; Abdullin, K.; Tokmoldin, C.

    2002-01-01

    The fundamental optical absorption of ion crystals characterizes the creation of different free low energetic electronic excitation (the excitons and electron-hole pairs), but their straight registration is not possible because of incommensurable big absorption factor of alkali halide monocrystals. So to registration the spectrums of alkali halide monocrystal very fine layers are necessary. We have received fine films of Nal and KCl in system of KCl-Nal-KCl, KCl-KI-KCl on the base of universal vacuum post VUP-4, VUP-5 by thermal evaporation. A unique spectral unit has been created For this on the basic the SDL-2 complex. Complex consists of radiator, systems of condensers, monochromators MDR-12 and MDR-23, receivers of radiation, controller by unit. Connect and control of monochromators by means of IBM-compatible computer has been created. Kinematics schemes of monochromators provide consequent removing on output slot of monochromatic radiation in operating range of each diffraction lattice and indication its wavelength. The tumbling diffraction lattices is done the crossbar engines SHDR-711. For this special plate of control and block of reinforcement for crossbar engines in monochromators MDR-12 and MDR-23 are designed and constructed. Created controller of monochromators consists of double cascade preamplifier on transistors n-p-n type (815G) and logical scheme, constructed on summers and K555 series triggers. The preamplifier is used for reinforcement of signal to available amplifier on transistors KT837D. The logical scheme reduces the number of used categories of bidirectional port and enables unhooking the feeding to the windings of crossbar engine at conservation of previous combination of signals. The connection controller of monochromators is done through controller of port of computer with use the parallel interface. For installing computerized system of collection and data processing is provided marketed by means of modern object-oriented programming

  17. Implementing evidence in an onco-haematology nursing unit: a process of change using participatory action research.

    Abad-Corpa, Eva; Delgado-Hito, Pilar; Cabrero-García, Julio; Meseguer-Liza, Cristobal; Zárate-Riscal, Carmen Lourdes; Carrillo-Alcaraz, Andrés; Martínez-Corbalán, José Tomás; Caravaca-Hernández, Amor

    2013-03-01

    To implement evidence in a nursing unit and to gain a better understanding of the experience of change within a participatory action research. Study design of a participatory action research type was use from the constructivist paradigm. The analytical-methodological decisions were inspired by Checkland Flexible Systems for evidence implementation in the nursing unit. The study was carried out between March and November 2007 in the isolation unit section for onco-haematological patients in a tertiary level general university hospital in Spain. Accidental sampling was carried out with the participation of six nurses. Data were collected using five group meetings and individual reflections in participants' dairies. The participant observation technique was also carried out by researchers. Data analysis was carried out by content analysis. The rigorous criteria were used: credibility, confirmability, dependence, transferability and reflexivity. A lack of use of evidence in clinical practice is the main problem. The factors involved were identified (training, values, beliefs, resources and professional autonomy). Their daily practice (complexity in taking decisions, variability, lack of professional autonomy and safety) was compared with an ideal situation (using evidence it will be possible to normalise practice and to work more effectively in teams by increasing safety and professional recognition). It was decided to create five working areas about several clinical topics (mucositis, pain, anxiety, satisfaction, nutritional assessment, nauseas and vomiting, pressure ulcers and catheter-related problems) and seven changes in clinical practice were agreed upon together with 11 implementation strategies. Some reflections were made about the features of the study: the changes produced; the strategies used and how to improve them; the nursing 'subculture'; attitudes towards innovation; and the commitment as participants in the study and as healthcare professionals. The

  18. Sectoral risk research about input-output structure of the United States

    Zhang, Mao

    2018-02-01

    There exist rare researches about economic risk in sectoral level, which is significantly important for risk prewarning. This paper employed status coefficient to measure the symmetry of economic subnetwork, which is negatively correlated with sectoral risk. Then, we do empirical research in both cross section and time series dimensions. In cross section dimension, we study the correlation between sectoral status coefficient and sectoral volatility, earning rate and Sharpe ratio respectively in the year 2015. Next, in the perspective of time series, we first investigate the correlation change between sectoral status coefficient and annual total output from 1997 to 2015. Then, we divide the 71 sectors in America into agriculture, manufacturing, services and government, compare the trend terms of average sectoral status coefficients of the four industries and illustrate the causes behind it. We also find obvious abnormality in the sector of housing. At last, this paper puts forward some suggestions for the federal government.

  19. Hazardous waste landfill research: U. S. E. P. A. (United States Environmental Protection Agency) Program

    Schomaker, N.B.

    1984-06-01

    The hazardous waste land disposal research program is collecting data necessary to support implementation of disposal guidelines mandated by the 'Resource Conservation and Recovery Act of 1976' (RCRA) PL 94-580. This program relating to the categorical areas of landfills, surface impoundments, and underground mines encompasses state-of-the-art documents, laboratory analysis, economic assessment, bench and pilot studies, and full-scale field verification studies. Over the next five years the research will be reported as Technical Resource Documents in support of the RCRA Guidance Documents. These documents will be used to provide guidance for conducting the review and evaluation of land disposal permit applications. This paper will present an overview of this program and will report the current status of the work.

  20. United Kingdom. Report 5 [Marine Radioecology. Current Research and Future Scope

    Mauchline, J.

    1967-01-01

    Four research programmes are suggested: Physical/chemical states of radionuclides in sea water related to their absorption rates by marine organisms; Studies of sea-water/ fresh-water interphases; To discover effects of raising the levels of background radiation by small amounts over long periods; Special studies of neutron-induced radioisotopes of elements such as chromium, manganese, iron, cobalt,, zinc, antimony, beryllium and iodine

  1. Maximising value from a United Kingdom Biomedical Research Centre: study protocol

    Greenhalgh, Trisha; Ovseiko, Pavel V.; Fahy, Nick; Shaw, Sara; Kerr, Polly; Rushforth, Alexander D.; Channon, Keith M.; Kiparoglou, Vasiliki

    2017-01-01

    Background Biomedical Research Centres (BRCs) are partnerships between healthcare organisations and universities in England. Their mission is to generate novel treatments, technologies, diagnostics and other interventions that increase the country’s international competitiveness, to rapidly translate these innovations into benefits for patients, and to improve efficiency and reduce waste in healthcare. As NIHR Oxford BRC (Oxford BRC) enters its third 5-year funding period, we seek to (1) a...

  2. United States Air Force Summer Faculty Research Program 1989. Program Technical Report. Volume 2

    1989-12-01

    968, June 1987. 22. E. Zielinski , H. Schweizer, S. Hausser, R. Stuber, M. H. Pilkuhn, and G. Weimann,"Systematics of laser operation in GaAs/AlGaAs...Mike Hinman, John Wagnon, Dave Froehlich, Scott Huse, Scott Shyne, and Ken Taylor. 79-3 I. Introduction Pattern Recognition (PR) is an important...many aspects of this research was also greatly appreciated. Finally, I want to thank Audrey Martinez, Al Leverette, Lt. Georke, Dave Fernald and

  3. The important role of public-sector research in the United States.

    2013-02-01

    Between 1970 and 2009, US public institutions participated in the research and development of 153 drugs, including 15 vaccines. Between 1990 and 2007, nearly 10% of all the new drugs and vaccines marketed in the US and about 20% of those representing a therapeutic advance originated in public institutions. The proportion of these drugs that represented a substantial therapeutic advance was over twice that of those produced exclusively by the private sector.

  4. Research on Key Technologies of Unit-Based CNC Machine Tool Assembly Design

    Zhongqi Sheng; Lei Zhang; Hualong Xie; Changchun Liu

    2014-01-01

    Assembly is the part that produces the maximum workload and consumed time during product design and manufacturing process. CNC machine tool is the key basic equipment in manufacturing industry and research on assembly design technologies of CNC machine tool has theoretical significance and practical value. This study established a simplified ASRG for CNC machine tool. The connection between parts, semantic information of transmission, and geometric constraint information were quantified to as...

  5. United States Air Force Summer Faculty Research Program. 1980 Program Management Report.

    1980-10-01

    COIVERECP _,-NITED ARFORCE_~~ 14ME FINAL f4- RESEARC - PROGRAM, AAEETRPOT 6. PERFORMING ORG. REPORT NURE 7. AUTH s4 ) ’..---- 8. CONTRACT OR GRANT NUMBFR(si...Winkofsky Multiband Airborne Radio System (MFBARS) Operational Impact Study: A Marketing Perspective 85 Application of Risk Analysis In the Dr. George...OPERATIONAL IMPACT STUDY: A MARKETING PEHSPECTIVE by E.P. WINKOFSKY ABSTRACT In order to transition technological advancements, research laboratories

  6. United States Air Force Research Initiation Program for 1988. Volume 4

    1990-04-01

    Proposal among the ones which were funded as follow-on research projects. 128-13 F. References 1. L. Wallentin and B. Moberg, Lecithin -cholesterol Acyl...Amicon YMT membrane) was evaluated for use in the separation of non-protein-bound cholesterol and hydrolyzable cholesterol esters. This system was...the cholesterol in whole urine passed through the membrane. As shown in Figure 1, about 23% of the total cholesterol and hydrolyzable conjugates in a

  7. United States Air Force Summer Faculty Research Program. 1985 Technical Report. Volume 1.

    1985-12-01

    this research effort was to evaluate the column technique for determining sorption coefficients of organic compounds onto soils. It was intended to... SORPTION COEFFICIENTS DETERMINED BY PULSE DISPLACEMENT Compound Flow Rate (mL/min) K,,q(mL/g) Trichioroethylene 0.2 0.054 0.2 0.057 Naphthalene 1.5...Vernon R. Allen Perfluorinated Polyalkylene Linked Polyimide 4 Quantifying Experience in the Cost Dr. Jihad A. Alsadek of Human Capital 5 The Effects

  8. United States Air Force Graduate Student Research Program. 1989 Program Management Report

    1989-12-01

    regular meetings and loneliness. Other weaknesses mentioned were specific to research problems faced by fellows. 8. Has this been a fruitful, worthwhile...Object Recognitio *** Same Report as Augustus Morr*** 61 Damage in Graphite/Epoxy Plates Bryan Foos Subjected to Low Velocity Impact (1988 Participant... face during the impact event. The depth of surface indentation and the extent of internal damage were measured and correlated with the impact energy

  9. JNC-JAERI united research report. A study on degradation of structural materials under irradiation environment in nuclear reactors

    Hoshiya, Taiji; Takaya, Shigeru; Nagae, Yuji; Aoto, Kazumi; Abe, Yasuhiro; Nakamura, Yasuo; Ueno, Fumiyoshi; Nemoto, Yoshiyuki; Miwa, Yukio; Tsukada, Takashi; Ohmi, Masao; Saito, Junichi; Shimizu, Michio

    2004-10-01

    Japan Nuclear Cycle Development Institute (JNC) and Japan Atomic Energy Research Institute (JAERI) have started a JNC-JAERI united research program cooperatively in fiscal year 2003, which has been aimed for efficient progress and synergistic effect on the research activities of both Institutes in order to lead the facing task of unification between JNC and JAERI. This study has been chosen one of the united research themes because it has been common objective for both Institutes in the research field of structural materials such as Fast Breeder Reactor and Light Water Reactors components. The purpose of the study is to clarify damage mechanism of structural materials under irradiation, and then to develop the methods for damage evaluation and detection in earlier stage of progressing process of damage along grain boundaries. In fiscal year 2003, magnetic flux density distribution (JNC) and micro-corrosion (JAERI) measurement apparatus were newly developed and equipped in Hot Facilities in two Institutes, respectively. The former apparatus, supersensitive Flux Gate sensor was installed, could detector leaked magnetic flux from material damaged by neutron irradiation. The latter one, Atomic Force Microscope was installed, could detect grain boundary corrosion loss after an electrochemical corrosion test of irradiated material. These apparatus were designed and produced in consideration of radiation resistance and remote-controlled operation to equip in hot cells. As the results of preliminary studies using Ni ion irradiated specimen, damage detection by corrosion property in grain boundary was possible but magnetic property change could not detect. We will start the study on neutron irradiation damage by employing the two apparatus as the next step. (author)

  10. Speaking of sex workers: How suppression of research has distorted the United States' domestic HIV response.

    Forbes, Anna

    2015-05-01

    Sex workers remain a vulnerable population at risk for HIV acquisition and transmission. Research suggests that interventions at the individual level, such as condom distribution, are less effective in preventing HIV among sex workers than structural changes such as allowing safer work settings and reducing the harassment and abuse of sex workers by clients and police. In the US, HIV incidence has not declined in the last decade. This may be due in part to its policy of wilful ignorance about sex work, but the data to resolve the question simply do not exist. Political actions such as PEPFAR's prostitution pledge and a congressional campaign against "waste, fraud and abuse" in research are products of an ideological environment that suppresses research on HIV prevention and treatment needs of sex workers. Even basic prevalence data are missing because there is no "sex worker" category in the US National HIV Behavior Surveillance System. However, international efforts are taking a public health approach and are calling for decriminalization of sex work, as the most effective public health strategy for reducing HIV incidence among sex workers. Although such an approach is not yet politically feasible in the US, some urgent practical policy changes can be implemented to improve data collection and generation of evidence to support HIV prevention and treatment programs targeting sex workers. Copyright © 2015. Published by Elsevier Ltd.

  11. Reflexivity and the "Acting Subject": Conceptualizing the Unit of Analysis in Qualitative Health Research.

    Shaw, James A

    2016-07-06

    The ways in which social scientists conceptualize the "reflexive" human subject have important consequences for how we go about our research. Whether and how we understand human subjects to be the authors of our own actions helps to structure what we say about health, health care, and the many other topics addressed in qualitative health research. In this article, I critically discuss assumptions of human reflexivity that are built into qualitative social science of health and medicine. I describe three alternative ways of understanding reflexive thought and human action derived from the theoretical works of Pierre Bourdieu, Bruno Latour, and George Lakoff and Mark Johnson, respectively. I then apply these three different ways of thinking about reflexivity and the acting subject to the analysis of an excerpt of participant observation data from a health services research study of transitions from hospital to home, illuminating the different kinds of analyses that arise from each perspective. I conclude with a call for social scientists to commit to the search for better ways of understanding the human subject, resisting the temptation to "settle" on theoretical statements that close down the path to more sophisticated conceptualizations of human thought and action. © The Author(s) 2016.

  12. RINGOs. Research and Independent Non-governmental Organisations to the United Nations Framework Convention on Climate Change (UNFCCC)

    2007-01-01

    RINGOs are organizations engaged in independent research and analysis aimed at developing sound strategies to address both the causes and consequences of global climate change. They form a constituency in their own right to contribute to the United Nations Framework Convention on Climate Change (UNFCCC), in a parallel way to ENGOs (Environment), BINGOs (Business and Industry), LGMAs (Local governments and municipal authorities) and the IPOs (Indigenous peoples organizations). During the COP and SB meetings of the UNFCCC the RINGOs organize meetings to discuss the developments of the negotiations. RINGOs have also been represented at workshops organized by the UNFCCC Secretariat. RINGO activities are co-ordinated by a steering committee

  13. The millstone industry a summary of research on quarries and producers in the United States, Europe and elsewhere

    Hockensmith, Charles D

    2009-01-01

    Since prehistoric times, the process of cutting rock to make millstones has been one of the most important industries in the world. The first part of this book compiles information on the millstone industry in the United States, which dates between the mid-1600s and the mid-1900s. Primarily based on archival research and brief accounts published in geological and historical volumes, it focuses on conglomerate, granite, flint, quartzite, gneiss, and sandstone quarries in different regions and states. The second part focuses on the millstone quarrying industry in Europe and other areas.

  14. Design of a microprocessor-based Control, Interface and Monitoring (CIM unit for turbine engine controls research

    Delaat, J. C.; Soeder, J. F.

    1983-01-01

    High speed minicomputers were used in the past to implement advanced digital control algorithms for turbine engines. These minicomputers are typically large and expensive. It is desirable for a number of reasons to use microprocessor-based systems for future controls research. They are relatively compact, inexpensive, and are representative of the hardware that would be used for actual engine-mounted controls. The Control, Interface, and Monitoring Unit (CIM) contains a microprocessor-based controls computer, necessary interface hardware and a system to monitor while it is running an engine. It is presently being used to evaluate an advanced turbofan engine control algorithm.

  15. Research on Dynamic Facility Layout Problem of Manufacturing Unit Considering Human Factors

    Jinying Li

    2018-01-01

    Full Text Available As many said, industry 4.0 is an epoch-making revolution which brought the manufacturing market much faster changes and severer competitions. As an important part of the manufacturing system, facility layout has direct impact on business benefit; at the same time, despite the intelligent factory, intelligent production has its own characteristics. However, there is one point on which industry and academia have basically formed a consensus: it is not true that industry 4.0 does not need human beings; on the contrary, human initiative plays an unabated role in the development of industry 4.0. This paper will focus on the dynamic facility layout of the manufacturing unit. Based on the system above and the traditional optimization model, a mathematic model is built to find the best solution combining safety, sustainability, high efficiency, and low cost. And penalty function with adaptive penalty factor and advanced artificial bee colony algorithm is used to solve the constrained model. In the end, by studying few cases, the model is proved to be effective in both efficiency improvement and the implementation of safe and comfort human-machine interaction.

  16. Research productivity of doctor of physical therapy faculty promoted in the southeastern United States.

    Littman, Marissa A; Sonne, James W; Smith, Gerald V

    2017-01-01

    Little information exists on the research productivity of successfully promoted tenure-track Doctor of Physical Therapy (DPT) faculty. To determine the research productivity that typically results in successful promotion. We collected publicly available curriculum vitae (CVs) from faculty currently in accredited DPT programs and who had been successfully promoted from an institution in the southeastern USA from 2000 through 2016. Total publication count, journal impact factor, funding, citations, and other metrics were analysed from 45 subjects of 22 of the 64 CAPTE-accredited DPT programs in the southeast. None of the studied metrics were normally distributed with time to promotion as determined by a Shapiro-Wilk test. These faculty exhibited a median publication count of 4, range 0 to 43; median of average citation count of 12.4, range 0 to 87.25; median of average journal impact factor of 2.866, range 0 to 6.280; median external funding received of $9910, range $0.00 to $19 543 198; and median author h-index of 3, range 0 to 17. The median number of years before promotion was 6, ranging from 3 to 13 years. Linear regression analysis indicates a poor fit with no significant correlation between years before promotion and any of the studied metrics. No correlation between journal impact factor and number of citations was observed (m = -0.22, p = 0.728, R 2  = 0.0003). Prior to promotion 31% (14 of 45) did not receive external funding and 24% (11 of 45) had a 0 h-index. The Carnegie Classification of the institution did not significantly correlate with research productivity metrics in this dataset (p = 0.213). While faculty unsuccessful in promotion were not identifiable using this method, this research can be used by faculty and committees to evaluate research productivity against regional data and promote competitive standards with peer institutions. CAPTE: Commission on Accreditation in Physical Therapist Education; DPT: Doctor of Physical Therapy.

  17. Report by the AERES on the unit: Research unit for man radiation protection under the supervision of establishments and bodies: IRSN

    2010-10-01

    This report is a kind of audit report on a research laboratory, whose activity is dedicated to man radiation protection, and is organized about four main themes: means to determine in any circumstances the dose received by a victim of an external irradiation or internal contamination, characterization of the biological effects ionizing radiations may create in a sane tissue, epidemiological approaches to the assessment of the exceeding risk associated with exposure to ionizing radiation on different populations, and experimental toxicology for the identification of biological effects induced par long duration and low dose exposures to some radionuclides. The authors discuss an assessment of the whole unit activities in terms of strengths and opportunities, productions and publications, scientific quality, influence and attractiveness (awards, recruitment capacity, capacity to obtain financing and to tender, participation to international programs), strategy and governance, and project. These same aspects are then discussed and commented for each theme: dosimetry, ionizing radiation pathology and experimental therapies, epidemiology of ionizing radiations, experimental and post-accidental radio-toxicology

  18. Sodium glucose co-transporter inhibitors for the management of diabetes mellitus: an opinion paper from the Endocrine and Metabolism Practice and Research Network of the American College of Clinical Pharmacy.

    Clements, Jennifer N; Whitley, Heather P; D'Souza, Jennifer J; Gross, Benjamin; Hess, Rick; Reece, Sara; Gentry, Chad; Shealy, Kayce

    2015-01-01

    Type 2 diabetes mellitus (T2DM) carries a high prevalence in the United States and worldwide. Therefore, the number of medication classes being developed and studied has grown. The individualized management of diabetes is accomplished by evaluating a medication's efficacy, safety, and cost, along with the patient's preference and tolerance to the medication. Sodium glucose co-transporter 2 inhibitors are a new therapeutic class indicated for the treatment of diabetes and have a unique mechanism of action, independent of beta-cell function. The first agent approved by the Food and Drug Administration (FDA) was canagliflozin in March 2013. Two agents - dapagliflozin and empagliflozin - were FDA-approved in January and July 2014, respectively. A clear understanding of the new class is needed to identify its appropriate use in clinical practice. Members of the American College of Clinical Pharmacy Endocrine and Metabolism Practice and Research Network reviewed available literature regarding this therapeutic class. The article addresses the advantages, disadvantages, emerging role, and patient education for sodium glucose co-transporter 2 inhibitors. Key limitations for this article include limited access to clinical trial data not published by the pharmaceutical company and limited data on products produced outside the United States.

  19. Community Extreme Tonnage User Service (CETUS): A 5000 Ton Open Research Facility in the United States

    Danielson, L. R.; Righter, K.; Vander Kaaden, K. E.; Rowland, R. L., II; Draper, D. S.; McCubbin, F. M.

    2017-12-01

    Large sample volume 5000 ton multi-anvil presses have contributed to the exploration of deep Earth and planetary interiors, synthesis of ultra-hard and other novel materials, and serve as a sample complement to pressure and temperature regimes already attainable by diamond anvil cell experiments. However, no such facility exists in the Western Hemisphere. We are establishing an open user facility for the entire research community, with the unique capability of a 5000 ton multi-anvil and deformation press, HERA (High pressure Experimental Research Apparatus), supported by a host of extant co-located experimental and analytical laboratories and research staff. We offer wide range of complementary and/or preparatory experimental options. Any required synthesis of materials or follow up experiments can be carried out controlled atmosphere furnaces, piston cylinders, multi-anvil, or experimental impact apparatus. Additionally, our division houses two machine shops that would facilitate any modification or custom work necessary for development of CETUS, one for general fabrication and one located specifically within our experimental facilities. We also have a general sample preparation laboratory, specifically for experimental samples, that allows users to quickly and easily prepare samples for ebeam analyses and more. Our focus as contract staff is on serving the scientific needs of our users and collaborators. We are seeking community expert input on multiple aspects of this facility, such as experimental assembly design, module modifications, immediate projects, and future innovation initiatives. We've built a cooperative network of 12 (and growing) collaborating institutions, including COMPRES. CETUS is a coordinated effort leveraging HERA with our extant experimental, analytical, and planetary process modelling instrumentation and expertise in order to create a comprehensive model of the origin and evolution of our solar system and beyond. We are looking to engage

  20. United States of America. Report 6 [Marine Radioecology. Current Research and Future Scope

    Rice, T.R.

    1967-01-01

    The cycling of radionuclides and effects of radiation in the marine environment are studied at the Radiobiological Laboratory. To gain a more complete understanding of the events following the introduction of radionuclides into the marine environment, we are investigating basic problems in ecology, radiobiology, biochemistry and geochemistry. Emphasis is placed on the cycling of radioactive trace metals through the water, sediment, and biota of the environment and the transmission of these metals through the food web of the sea. Because ionizing radiations from the introduced radionuclides interact with other environmental factors to affect the growth and survival of the biota, we are determining the responses of marine organisms to radiation in various environmental situations. Laboratory facilities consist of a two-storey laboratory, a highlevel radiation building, and a storage building containing a crematory for ashing radioactive organisms. The main building has office and' laboratory space for approximately 16 investigators and supporting staff plus space for visiting investigators. There are now 23 permanent staff members. The main building houses two large salt-water laboratories, three constant temperature rooms and several counting and instrument rooms. Salt water is supplied to the salt-water laboratories, three research laboratories and to the radiation buildings Specialized equipment available to investigators includes an atomic absorption spectrophotometer; differential respirometer; continuous flow, refrigerated centrifuge; 512-channel analyser and low-level detecting equipment; a small animal detector, single-channel analyser equipped with detectors of various sizes, an X-ray machine; and two cobalt-60 irradiators: a 7-curie single-point source used for continuous irradiation and a 1500-curie self-contained source in which marine organisms can be irradiated in flowing sea water. Field equipment is also available. Research activities of the

  1. United States of America. Report 6 [Marine Radioecology. Current Research and Future Scope

    Rice, T. R. [Radiobiological Laboratory, Beaufort, NC (United States); others, and

    1967-03-15

    The cycling of radionuclides and effects of radiation in the marine environment are studied at the Radiobiological Laboratory. To gain a more complete understanding of the events following the introduction of radionuclides into the marine environment, we are investigating basic problems in ecology, radiobiology, biochemistry and geochemistry. Emphasis is placed on the cycling of radioactive trace metals through the water, sediment, and biota of the environment and the transmission of these metals through the food web of the sea. Because ionizing radiations from the introduced radionuclides interact with other environmental factors to affect the growth and survival of the biota, we are determining the responses of marine organisms to radiation in various environmental situations. Laboratory facilities consist of a two-storey laboratory, a highlevel radiation building, and a storage building containing a crematory for ashing radioactive organisms. The main building has office and' laboratory space for approximately 16 investigators and supporting staff plus space for visiting investigators. There are now 23 permanent staff members. The main building houses two large salt-water laboratories, three constant temperature rooms and several counting and instrument rooms. Salt water is supplied to the salt-water laboratories, three research laboratories and to the radiation buildings Specialized equipment available to investigators includes an atomic absorption spectrophotometer; differential respirometer; continuous flow, refrigerated centrifuge; 512-channel analyser and low-level detecting equipment; a small animal detector, single-channel analyser equipped with detectors of various sizes, an X-ray machine; and two cobalt-60 irradiators: a 7-curie single-point source used for continuous irradiation and a 1500-curie self-contained source in which marine organisms can be irradiated in flowing sea water. Field equipment is also available. Research activities of the

  2. United States of America. Report 4 [Marine Radioecology. Current Research and Future Scope

    Osterberg, C.; Pearcy, W.; Carey, A. Jr.; McCauley, J.

    1967-01-01

    Present research programme: Ecological studies of radioactivity in the Columbia River estuary and adjacent Pacific Ocean. Our objectives are: (a) To determine fractionation of radionuclides introduced by the Hanford nuclear reactors in the water, sediments, and biota; (b) To observe concentrating mechanisms, and flow through food chains; (c) To determine rates of vertical transfer across the pyonocline and through upper 1000 metres; (d) To determine depths to which radioactivity has penetrated, using benthos (down to 3000 metres) as biological indicators; (e) To determine physical and chemical states of artificial radionuclides in ocean

  3. United States Air Force Summer Faculty Research Program (1987). Program Technical Report. Volume 2.

    1987-12-01

    Psychology Dept. of Behavioral Sciences Assigned: HRL/MO Drury College Springfield, MO 65802 (417) 865-8731 Dr. Alastair McAulay Degree: Ph.D...Michael D. Matthews, Ph.D. Academic Rank: Assistant Professor Department: Behavioral Sciences Department University: Drury College Research Location... colin -matcd. 1 aWO :wcc.-io o the iceI for equal tie. Stiiyand lineanity C).~ ~ ~ ~ ~~It ret n-1’ 11~ ~eg~ ist be mea-siirec. to femy arialog ctio Aw

  4. Directory of Solar Energy Research Activities in the United States: First Edition, May 1980. [1220 projects

    None

    1980-05-01

    Information covering 1220, FY 1978 and FY 1979 solar energy research projects is included. In addition to the title and text of project summaries, the directory contains the following indexes: subject index, investigator index, performing organization index, and supporting organization index. This information was registered with the Smithsonian Science Information Exchange by Federal, State, and other supporting organizations. The project summaries are categorized in the following areas: biomass, ocean energy, wind energy,photovoltaics, photochemical energy conversion, photobiological energy conversion, solar heating and cooling, solar process heat, solar collectors and concentrators, solar thermal electric generation, and other solar energy conversion. (WHK)

  5. Indium phosphide solar cell research in the United States: Comparison with non-photovoltaic sources

    Weinberg, I.; Swartz, C. K.; Hart, R. E., Jr.

    1989-01-01

    Highlights of the InP solar cell research program are presented. Homojunction cells with efficiencies approaching 19 percent are demonstrated, while 17 percent is achieved for ITO/InP cells. The superior radiation resistance of the two latter cell configurations over both Si and GaAs cells has been shown. InP cells aboard the LIPS3 satellite show no degradation after more than a year in orbit. Computed array specific powers are used to compare the performance of an InP solar cell array to solar dynamic and nuclear systems.

  6. United Kingdom. Report 2 [Marine Radioecology. Current Research and Future Scope

    Martin, J.H.

    1967-01-01

    Present research programme: 1.1. The biology of the Solway Firth in relation to the movement and accumulation of radioactive materials. 1.2. To determine the maximum capacity of the Solway Firth for the receipt of radioactive effluent. 1.3. The work has included study of the estuarine currents, using drifters; study of the relationship between deposition of radioactivity and soil by means of transects; studies of the nature and variation, with season and position in the estuary, of fish feeding; and studies of the flora and fauna of the estuary (including some minor studies of how they are affected by climatic changes)

  7. Synthesis on Quaternary aeolian research in the unglaciated eastern United States

    Markewich, Helaine Walsh; Litwin, Ronald J.; Wysocki, Douglas A.; Pavich, Milan J.

    2015-01-01

    Late-middle and late Pleistocene, and Holocene, inland aeolian sand and loess blanket >90,000 km2 of the unglaciated eastern United States of America (USA). Deposits are most extensive in the Lower Mississippi Valley (LMV) and Atlantic Coastal Plain (ACP), areas presently lacking significant aeolian activity. They provide evidence of paleoclimate intervals when wind erosion and deposition were dominant land-altering processes. This study synthesizes available data for aeolian sand deposits in the LMV, the Eastern Gulf Coastal Plain (EGCP) and the ACP, and loess deposits in the Middle Atlantic Coastal Plain (MACP). Data indicate: (a) the most recent major aeolian activity occurred in response to and coincident with growth and decay of the Laurentide Ice Sheet (LIS); (b) by ∼40 ka, aeolian processes greatly influenced landscape evolution in all three regions; (c) aeolian activity peaked in OIS2; (d) OIS3 and OIS2 aeolian records are in regional agreement with paleoecological records; and (e) limited aeolian activity occurred in the Holocene (EGCP and ACP). Paleoclimate and atmospheric-circulation models (PCMs/ACMs) for the last glacial maximum (LGM) show westerly winter winds for the unglaciated eastern USA, but do not resolve documented W and SW winds in the SEACP and WNW and N winds in the MACP. The minimum areal extent of aeolian deposits in the EGCP and ACP is ∼10,000 km2. For the LMV, it is >80,000 km2. Based on these estimates, published PCMs/ACMs likely underrepresent the areal extent of LGM aeolian activity, as well as the extent and complexity of climatic changes during this interval.

  8. Substance use disorders among immigrants in the United States: A research update.

    Salas-Wright, Christopher P; Vaughn, Michael G; Clark Goings, Trenette T; Córdova, David; Schwartz, Seth J

    2018-01-01

    There is a critical need for the most current information available on the prevalence of substance use disorders (SUD) among immigrants vis-à-vis that of individuals born in the United States (US). We report the prevalence of SUDs among immigrants from major world regions and top immigrant-sending countries, and assess key moderators (i.e., age, gender, family income, age of migration, time in US) of the relationship between immigrant status and SUD risk. The data source used for the present study is the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC-III, 2012-2013), a nationally representative survey of 36,309 civilian, non-institutionalized adults ages 18 and older in the US. Logistic regression was employed to examine the relationship between immigrant status and SUD risk. Immigrants were found to be substantially less likely than US-born individuals to be diagnosed with a past-year or lifetime SUD, including alcohol, cannabis, cocaine, and opioid use disorders. These findings held across major world region and among immigrants from the top-ten immigrant sending nations, and across differences in age, gender, family income, age of migration, and time spent in the US. Results from the present study provide up-to-date and cogent evidence that immigrants use alcohol and drugs, and meet criteria for SUDs, at far lower rates than do US-born individuals. Moreover, we provide new evidence that the protective effect of nativity holds for immigrants from an array of global regions and sending countries, and across key demographic and migration-related differences. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Synthesis on Quaternary aeolian research in the unglaciated eastern United States

    Markewich, Helaine W.; Litwin, Ronald J.; Wysocki, Douglas A.; Pavich, Milan J.

    2015-06-01

    Late-middle and late Pleistocene, and Holocene, inland aeolian sand and loess blanket >90,000 km2 of the unglaciated eastern United States of America (USA). Deposits are most extensive in the Lower Mississippi Valley (LMV) and Atlantic Coastal Plain (ACP), areas presently lacking significant aeolian activity. They provide evidence of paleoclimate intervals when wind erosion and deposition were dominant land-altering processes. This study synthesizes available data for aeolian sand deposits in the LMV, the Eastern Gulf Coastal Plain (EGCP) and the ACP, and loess deposits in the Middle Atlantic Coastal Plain (MACP). Data indicate: (a) the most recent major aeolian activity occurred in response to and coincident with growth and decay of the Laurentide Ice Sheet (LIS); (b) by ∼40 ka, aeolian processes greatly influenced landscape evolution in all three regions; (c) aeolian activity peaked in OIS2; (d) OIS3 and OIS2 aeolian records are in regional agreement with paleoecological records; and (e) limited aeolian activity occurred in the Holocene (EGCP and ACP). Paleoclimate and atmospheric-circulation models (PCMs/ACMs) for the last glacial maximum (LGM) show westerly winter winds for the unglaciated eastern USA, but do not resolve documented W and SW winds in the SEACP and WNW and N winds in the MACP. The minimum areal extent of aeolian deposits in the EGCP and ACP is ∼10,000 km2. For the LMV, it is >80,000 km2. Based on these estimates, published PCMs/ACMs likely underrepresent the areal extent of LGM aeolian activity, as well as the extent and complexity of climatic changes during this interval.

  10. Integrating psychological research on girls with feminist activism: a model for building a liberation psychology in the United States.

    Grant, Kathryn E; Finkelstein, Jo-Ann S; Lyons, Aoife L

    2003-03-01

    A liberation psychology is needed to bridge the gap between psychology's focus on individual distress and broad social forces that foster such distress. We offer a model for bridging this gap by focusing on a specific area of psychology (psychological research on girls) and a specific social movement (feminist activism). Psychological research on girls and feminist activism share the common goal of improving the lives of girls and women. However, both have fallen short of this goal. This is due, in part, to the weaknesses associated with each endeavor and to the fact that the complementary strengths of each have remained isolated from the other. In this paper, we propose a common language and shared framework to integrate psychological research with feminist activism. First, we review the basic strengths and weaknesses associated with psychological research and feminist activism, with a particular focus on how they are distinct from one another. Second, we provide a taxonomic framework for integrating these two areas on the basis of the stress paradigm, with specific examples provided from our recent reviews of the literature and our own empirical work with adolescent girls. Finally, we conclude with recommendations for future work needed to integrate psychological research on girls with feminist activism toward the goal of building a liberation psychology in the United States.

  11. Proposal for coordinated health research in PFAS-contaminated communities in the United States.

    Bruton, Thomas A; Blum, Arlene

    2017-11-14

    The drinking water of more than six million Americans in numerous communities has been found to contain highly fluorinated chemicals at concentrations of concern. Certain of these chemicals, including perfluorooctanoic acid and perfluorooctane sulfonic acid, are known to be persistent, bioaccumulative, and associated with adverse health outcomes in humans and animal models. The possible health impacts of exposure to highly fluorinated chemicals are of great concern to communities whose water has been impacted. Community members want information, and are asking for biomonitoring, exposure pathway analysis, and health studies. Governmental agencies are striving to deal with these multiple concerns in the face of information and resource constraints. We propose the development of a high-level research strategy to maximize what can be learned about health effects of highly fluorinated chemicals and methods to reduce or eliminate exposure. We suggest coordinating the research across multiple communities for greater statistical power. If implemented, such a strategy could help to generate information and evidence integration to enable regulatory decision making and contribute to reducing future exposures.

  12. An Examination of Incentive Strategies to Increase Participation in Outcomes Research for an Adolescent Inpatient Unit.

    Ha, Carolyn; Madan, Alok; Long, Tessa A; Sharp, Carla

    2016-05-01

    Tracking adolescent outcomes after inpatient hospitalization is important in informing clinical care for this age group, as inpatient care is one of the most expensive treatment modalities. This study examined 4 incentive strategies used to maintain adolescent participation in follow-up research (at 6, 12, and 18 mo) after their discharge from the hospital (N=267). A generalized estimation equation approach was taken to investigate whether different incentive strategies predicted adolescent completion of the follow-up assessments at each time point. Findings demonstrate that implementation of social worker contact significantly differed from other incentive strategies in increasing adolescent completion of follow-up assessments (Z=2.51, P=0.012) over the 3 time points, even when controlling for age and sex. Although these findings ultimately need to be confirmed through a randomized controlled study of incentive strategies, they provide preliminary support for the notion that relational incentives, such as maintaining contact with a member of the clinical team at the hospital, may be particularly important in promoting adolescent participation in outcomes research.

  13. Overview of the dairy and food processing research conducted at the Dairy and Functional Foods Research Unit, ERRC, and research to develop sustainable food processes

    The DFFRU is dedicated to solving critical problems in the utilization of milk and specialty crop byproducts by developing high-quality, value-added functional foods and consumer products. The presentation will give an overview of the research projects that will benefit human health and well-being. ...

  14. Regional management units for marine turtles: a novel framework for prioritizing conservation and research across multiple scales.

    Wallace, Bryan P; DiMatteo, Andrew D; Hurley, Brendan J; Finkbeiner, Elena M; Bolten, Alan B; Chaloupka, Milani Y; Hutchinson, Brian J; Abreu-Grobois, F Alberto; Amorocho, Diego; Bjorndal, Karen A; Bourjea, Jerome; Bowen, Brian W; Dueñas, Raquel Briseño; Casale, Paolo; Choudhury, B C; Costa, Alice; Dutton, Peter H; Fallabrino, Alejandro; Girard, Alexandre; Girondot, Marc; Godfrey, Matthew H; Hamann, Mark; López-Mendilaharsu, Milagros; Marcovaldi, Maria Angela; Mortimer, Jeanne A; Musick, John A; Nel, Ronel; Pilcher, Nicolas J; Seminoff, Jeffrey A; Troëng, Sebastian; Witherington, Blair; Mast, Roderic B

    2010-12-17

    Resolving threats to widely distributed marine megafauna requires definition of the geographic distributions of both the threats as well as the population unit(s) of interest. In turn, because individual threats can operate on varying spatial scales, their impacts can affect different segments of a population of the same species. Therefore, integration of multiple tools and techniques--including site-based monitoring, genetic analyses, mark-recapture studies and telemetry--can facilitate robust definitions of population segments at multiple biological and spatial scales to address different management and research challenges. To address these issues for marine turtles, we collated all available studies on marine turtle biogeography, including nesting sites, population abundances and trends, population genetics, and satellite telemetry. We georeferenced this information to generate separate layers for nesting sites, genetic stocks, and core distributions of population segments of all marine turtle species. We then spatially integrated this information from fine- to coarse-spatial scales to develop nested envelope models, or Regional Management Units (RMUs), for marine turtles globally. The RMU framework is a solution to the challenge of how to organize marine turtles into units of protection above the level of nesting populations, but below the level of species, within regional entities that might be on independent evolutionary trajectories. Among many potential applications, RMUs provide a framework for identifying data gaps, assessing high diversity areas for multiple species and genetic stocks, and evaluating conservation status of marine turtles. Furthermore, RMUs allow for identification of geographic barriers to gene flow, and can provide valuable guidance to marine spatial planning initiatives that integrate spatial distributions of protected species and human activities. In addition, the RMU framework--including maps and supporting metadata--will be an

  15. Regional Management Units for Marine Turtles: A Novel Framework for Prioritizing Conservation and Research across Multiple Scales

    Wallace, Bryan P.; DiMatteo, Andrew D.; Hurley, Brendan J.; Finkbeiner, Elena M.; Bolten, Alan B.; Chaloupka, Milani Y.; Hutchinson, Brian J.; Abreu-Grobois, F. Alberto; Amorocho, Diego; Bjorndal, Karen A.; Bourjea, Jerome; Bowen, Brian W.; Dueñas, Raquel Briseño; Casale, Paolo; Choudhury, B. C.; Costa, Alice; Dutton, Peter H.; Fallabrino, Alejandro; Girard, Alexandre; Girondot, Marc; Godfrey, Matthew H.; Hamann, Mark; López-Mendilaharsu, Milagros; Marcovaldi, Maria Angela; Mortimer, Jeanne A.; Musick, John A.; Nel, Ronel; Pilcher, Nicolas J.; Seminoff, Jeffrey A.; Troëng, Sebastian; Witherington, Blair; Mast, Roderic B.

    2010-01-01

    Background Resolving threats to widely distributed marine megafauna requires definition of the geographic distributions of both the threats as well as the population unit(s) of interest. In turn, because individual threats can operate on varying spatial scales, their impacts can affect different segments of a population of the same species. Therefore, integration of multiple tools and techniques — including site-based monitoring, genetic analyses, mark-recapture studies and telemetry — can facilitate robust definitions of population segments at multiple biological and spatial scales to address different management and research challenges. Methodology/Principal Findings To address these issues for marine turtles, we collated all available studies on marine turtle biogeography, including nesting sites, population abundances and trends, population genetics, and satellite telemetry. We georeferenced this information to generate separate layers for nesting sites, genetic stocks, and core distributions of population segments of all marine turtle species. We then spatially integrated this information from fine- to coarse-spatial scales to develop nested envelope models, or Regional Management Units (RMUs), for marine turtles globally. Conclusions/Significance The RMU framework is a solution to the challenge of how to organize marine turtles into units of protection above the level of nesting populations, but below the level of species, within regional entities that might be on independent evolutionary trajectories. Among many potential applications, RMUs provide a framework for identifying data gaps, assessing high diversity areas for multiple species and genetic stocks, and evaluating conservation status of marine turtles. Furthermore, RMUs allow for identification of geographic barriers to gene flow, and can provide valuable guidance to marine spatial planning initiatives that integrate spatial distributions of protected species and human activities. In addition

  16. Sono-leather technology with ultrasound: a boon for unit operations in leather processing - review of our research work at Central Leather Research Institute (CLRI), India.

    Sivakumar, Venkatasubramanian; Swaminathan, Gopalaraman; Rao, Paruchuri Gangadhar; Ramasami, Thirumalachari

    2009-01-01

    Ultrasound is a sound wave with a frequency above the human audible range of 16 Hz to 16 kHz. In recent years, numerous unit operations involving physical as well as chemical processes are reported to have been enhanced by ultrasonic irradiation. There have been benefits such as improvement in process efficiency, process time reduction, performing the processes under milder conditions and avoiding the use of some toxic chemicals to achieve cleaner processing. These could be a better way of augmentation for the processes as an advanced technique. The important point here is that ultrasonic irradiation is physical method activation rather than using chemical entities. Detailed studies have been made in the unit operations related to leather such as diffusion rate enhancement through porous leather matrix, cleaning, degreasing, tanning, dyeing, fatliquoring, oil-water emulsification process and solid-liquid tannin extraction from vegetable tanning materials as well as in precipitation reaction in wastewater treatment. The fundamental mechanism involved in these processes is ultrasonic cavitation in liquid media. In addition to this there also exist some process specific mechanisms for the enhancement of the processes. For instance, possible real-time reversible pore-size changes during ultrasound propagation through skin/leather matrix could be a reason for diffusion rate enhancement in leather processing as reported for the first time. Exhaustive scientific research work has been carried out in this area by our group working in Chemical Engineering Division of CLRI and most of these benefits have been proven with publications in valued peer-reviewed international journals. The overall results indicate that about 2-5-fold increase in the process efficiency due to ultrasound under the given process conditions for various unit operations with additional benefits. Scale-up studies are underway for converting these concepts in to a real viable larger scale operation. In

  17. Unite research with what citizens do for fun: "recreational monitoring" of marine biodiversity.

    Goffredo, Stefano; Pensa, Francesco; Neri, Patrizia; Orlandi, Antonio; Gagliardi, Maria Scola; Velardi, Angela; Piccinetti, Corrado; Zaccanti, Francesco

    2010-12-01

    Institutes often lack funds and manpower to perform large-scale biodiversity monitoring. Citizens can be involved, contributing to the collection of data, thus decreasing costs. Underwater research requires specialist skills and SCUBA certification, and it can be difficult to involve volunteers. The aim of this study was to involve large numbers of recreational divers in marine biodiversity monitoring for increasing the environmental education of the public and collecting data on the status of marine biodiversity. Here we show that thousands of recreational divers can be enrolled in a short time. Using specially formulated questionnaires, nonspecialist volunteers reported the presence of 61 marine taxa encountered during recreational dives, performed as regular sport dives. Validation trials were carried out to assess the accuracy and consistency of volunteer-recorded data, and these were compared to reference data collected by an experienced researcher. In the majority of trials (76%) volunteers performed with an accuracy and consistency of 50-80%, comparable to the performance of conservation volunteer divers on precise transects in other projects. The recruitment of recreational divers involved the main diving and tour operators in Italy, a popular scientific magazine, and mass media. During the four-year study, 3825 divers completed 18757 questionnaires, corresponding to 13539 diving hours. The volunteer-sightings-based index showed that in the monitored area the biodiversity status did not change significantly within the project time scale, but there was a significant negative correlation with latitude, suggesting improved quality in the southernmost areas. This trend could be related to the presence of stressors in the northern areas and has been supported by investigations performed by the Italian Ministry of the Environment. The greatest limitation with using volunteers to collect data was the uneven spatial distribution of samples. The benefits were the

  18. Some research and development on power plants with helium gas turbine units

    Kaplan, M.P.

    1983-01-01

    Research and development projects pursued at the S. M. Kirov Kharkov Turbine Factory Production Association for Nuclear Turbomachinery Manufacturing have probed into prospective use of helium as the working medium in nuclear power facilities. The projects under study are compared mainly in terms of heat efficiency. Solutions are also being sought for problems centering around high efficiency in helium turbocompressors combined with shortening of axial dimensions. Different types of power plants are being compared with attention given to features of the flow passages of turbocompressors. The projects were developed for helium temperatures and pressures downstream of the reactor 950 0 C and 4.8 MPa, and thermal reactor output 2250 MW(th). The reactor is assumed to be served by two turbine plants in the turbocompressor designs

  19. Cooperative earthquake research between the United States and the People's Republic of China

    Russ, D.P.; Johnson, L.E.

    1986-01-01

    This paper describes cooperative research by scientists of the US and the People's Republic of China (PRC) which has resulted in important new findings concerning the fundamental characteristics of earthquakes and new insight into mitigating earthquake hazards. There have been over 35 projects cooperatively sponsored by the Earthquake Studies Protocol in the past 5 years. The projects are organized into seven annexes, including investigations in earthquake prediction, intraplate faults and earthquakes, earthquake engineering and hazards investigation, deep crustal structure, rock mechanics, seismology, and data exchange. Operational earthquake prediction experiments are currently being developed at two primary sites: western Yunnan Province near the town of Xiaguan, where there are several active faults, and the northeast China plain, where the devastating 1976 Tangshan earthquake occurred.

  20. Recent Trends in Oral Cavity Cancer Research Support in the United States.

    Fribley, A M; Svider, P F; Warner, B M; Garshott, D M; Raza, S N; Kirkwood, K L

    2017-01-01

    The objectives were to characterize oral cavity cancer (OCC) funding from the National Institutes of Health (NIH) with a secondary aim of comparing NIH support provided to OCC and other malignancies. NIH awards supporting OCC inquiry from 2000 to 2014 were accessed from the NIH RePORTER database. These data were used to evaluate temporal trends and the role of human papilloma virus and to determine the academic training and professional profiles of the principal investigators. Comparison of 2014 funding levels with other malignancies was also performed, controlling for incidence. Overall funding totals decreased considerably after 2009. Funding administered through the National Institute of Dental and Craniofacial Research (NIDCR) was 6.5 times greater than dollars awarded by the National Cancer Institute in 2000. During the period evaluated, NIDCR support decreased in most years, while National Cancer Institute support increased and approached NIDCR funding levels. Funding for human papilloma virus-related projects gradually rose, from 3.4% of dollars in 2000 to 2004 to 6.2% from 2010 to 2014 ( P < 0.05). A majority of principal investigators had a PhD omnia solus (57%), and 13% possessed dual PhD/clinical degrees. Among clinicians with specialty training, otolaryngologists and oral/maxillofacial pathologists garnered the most funding. OCC had a 2014 funding:incidence ratio of $785, much lower than for other malignancies. There has been increased volatility in funding support in recent years possibly due to budget cuts and sequestration. The National Cancer Institute has played an increasingly important role in supporting OCC research, concomitant with decreasing NIDCR support. Our findings suggest that OCC is underfunded relative to other non-oral cavity malignancies, indicating a need to increase the focus on rectifying the disparity.

  1. Co-ordinated research programme on application of stable isotope tracer methods to studies of amino acid, protein, and energy metabolism in malnourished populations of developing countries. Report on the second research co-ordination meeting

    1996-01-01

    The use of isotopes has revolutionized the field of human nutrition research, but has been of greatest benefit to industrialized countries. The International Atomic Energy Agency is sponsoring programmes using isotopic and related technologies in human nutrition research to address issues that are of priority to developing countries. Scientists participating in the Coordinated Research Programme (CRP) on ''Amino Acid and Protein Metabolism in Malnourished Populations of Developing Countries'' are conducting research on the interaction between infection and amino acid metabolism, particularly the potential diversion of substrates from anabolic pathways to fight infection in marginally nourished children during periods of infections. This topic is of great importance to the nutritional status of children in developing countries, who frequently or chronically have infections and who, as a consequence, may have alterations in nutrient requirements. The CRP has developed and implemented a standardized protocol for measuring leucine oxidation during infection in 8 different countries. The CRP is expected to contribute important new knowledge about interactions between protein utilization, the stresses of unhygienic environments, and infections in marginally nourished people. This information is expected to be applicable to efforts to increase efficient utilization of limited food resources in developing countries. Another highlight of the CRP is that it represents an international team of nutrition scientists who together are building nutritional biology research capabilities in developing countries. Refs, figs, tabs

  2. Co-ordinated research programme on application of stable isotope tracer methods to studies of amino acid, protein, and energy metabolism in malnourished populations of developing countries. Report on the second research co-ordination meeting

    NONE

    1997-12-31

    The use of isotopes has revolutionized the field of human nutrition research, but has been of greatest benefit to industrialized countries. The International Atomic Energy Agency is sponsoring programmes using isotopic and related technologies in human nutrition research to address issues that are of priority to developing countries. Scientists participating in the Coordinated Research Programme (CRP) on ``Amino Acid and Protein Metabolism in Malnourished Populations of Developing Countries`` are conducting research on the interaction between infection and amino acid metabolism, particularly the potential diversion of substrates from anabolic pathways to fight infection in marginally nourished children during periods of infections. This topic is of great importance to the nutritional status of children in developing countries, who frequently or chronically have infections and who, as a consequence, may have alterations in nutrient requirements. The CRP has developed and implemented a standardized protocol for measuring leucine oxidation during infection in 8 different countries. The CRP is expected to contribute important new knowledge about interactions between protein utilization, the stresses of unhygienic environments, and infections in marginally nourished people. This information is expected to be applicable to efforts to increase efficient utilization of limited food resources in developing countries. Another highlight of the CRP is that it represents an international team of nutrition scientists who together are building nutritional biology research capabilities in developing countries. Refs, figs, tabs.

  3. Strategic Academic Unit as a Synergy between Education, Research and Innovations and Its Position in Knowledge Life Cycle

    Pryakhin, A.; Tikhomirov, G.

    2016-01-01

    Full text: The strategic goal of MEPhI is to become a global leader in education, science and innovations. Influence of the world development and current trends imply flexibility of the university to respond to today’s challenges and ability to introduce new forms and organizational structures for effective and efficient education. Strategic Academic Unit (SAE) is a new academic and scientific entity engaging nuclear industry partners in processes related to knowledge breeding, handling, and transfer through education and experience. The new SAE is titled as Institute of Nuclear Physics and Engineering (INPhE). SAE comprises objects belonging to three kinds or classes: education, research, and innovations. Education objects are education programs, teachers, students. Research objects are scientific teams and related mega-science laboratories working for fundamental and applied research. Innovations are typically knowledge assets created in research groups together with industrial partners and customers, recognized by the market, and used by all involved players for the next generations in the knowledge breeding chains. The key elements representing capacity of the SAE and maturity of the university are knowledge assets which are outputs of the intellectual activity and intellectual property itself, that they create. (author

  4. Impact of Subspecialty Fellowship Training on Research Productivity Among Academic Plastic Surgery Faculty in the United States.

    Sood, Aditya; Therattil, Paul J; Chung, Stella; Lee, Edward S

    2015-01-01

    The impact of subspecialty fellowship training on research productivity among academic plastic surgeons is unknown. The authors' aim of this study was to (1) describe the current fellowship representation in academic plastic surgery and (2) evaluate the relationship between h-index and subspecialty fellowship training by experience and type. Academic plastic surgery faculty (N = 590) were identified through an Internet-based search of all ACGME-accredited integrated and combined residency programs. Research output was measured by h-index from the Scopus database as well as a number of peer-reviewed publications. The Kruskal-Wallis test, with a subsequent Mann-Whitney U test, was used for statistical analysis to determine correlations. In the United States, 72% (n = 426) of academic plastic surgeons had trained in 1 or more subspecialty fellowship program. Within this cohort, the largest group had completed multiple fellowships (28%), followed by hand (23%), craniofacial (22%), microsurgery (15%), research (8%), cosmetic (3%), burn (2%), and wound healing (0.5%). Higher h-indices correlated with a research fellowship (12.5; P productivity compared with their colleagues. Craniofacial-trained physicians also demonstrated a higher marker for academic productivity than multiple other specialties. In this study, we show that the type and number of fellowships influence the h-index and further identification of such variables may help improve academic mentorship and productivity within academic plastic surgery.

  5. Expanding the TRI Network for Doctoral Researchers in the Fields of Terrorism, Political Violence and Armed Conflict to the United States of America and Russia

    Alex P. Schmid; Gordon Clubb; Jason Rineheart; Yulia  Netesova

    2011-01-01

    In September 2011, the Terrorism Research Initiative (TRI) announced the creation of a post-graduate terrorism research network in the United Kingdom. The idea was to compile a list of post-graduates conducting research in the UK in the overlapping fields of terrorism, political violence, and armed conflict. While much research is conducted in these three overlapping fields, those involved in research are often unsure what is going on outside their own university department. They also wonder ...

  6. University research reactors in the United States: Their role and value

    1988-01-01

    This report is primarily addressed to the people who make decisions affecting the levels of future university reactor programs URR: university administrators, department heads, federal policy makers, state and local policy makers, those in industry and government who depend upon a supply of nuclear-trained personnel, and those who are concerned with the future of the many sciences that benefit from the unique capabilities of nuclear-based techniques as well as from the nuclear sciences themselves. The major thrust of this report is to illustrate the scientific and social benefits and contributions associated with well-managed and well-funded university reactor programs. The intent is to help a decision maker gain a perspective and appreciation of the scientific, academic, social, and technical values of URR programs. The report also examines the role of university-like reactors in Europe, where a productive community of researchers is apparently served in an exemplary manner. The committee, assesses the security and safeguard needs at small reactors in a university setting in order to help gain a perspective on the potential hazards and relative risks involved. The last chapter discusses the kind of commitment and support needed if a significant population of URRs is to remain productive. 83 refs., 11 figs., 2 tabs

  7. Severe metabolic or mixed acidemia on intensive care unit admission: incidence, prognosis and administration of buffer therapy. A prospective, multiple-center study.

    Jung, Boris; Rimmele, Thomas; Le Goff, Charlotte; Chanques, Gérald; Corne, Philippe; Jonquet, Olivier; Muller, Laurent; Lefrant, Jean-Yves; Guervilly, Christophe; Papazian, Laurent; Allaouchiche, Bernard; Jaber, Samir

    2011-01-01

    In this study, we sought describe the incidence and outcomes of severe metabolic or mixed acidemia in critically ill patients as well as the use of sodium bicarbonate therapy to treat these illnesses. We conducted a prospective, observational, multiple-center study. Consecutive patients who presented with severe acidemia, defined herein as plasma pH below 7.20, were screened. The incidence, sodium bicarbonate prescription and outcomes of either metabolic or mixed severe acidemia were analyzed. Among 2, 550 critically ill patients, 200 (8%) presented with severe acidemia, and 155 (6% of the total admissions) met the inclusion criteria. Almost all patients needed mechanical ventilation and vasopressors during their ICU stay, and 20% of them required renal replacement therapy within the first 24 hours of their ICU stay. Severe metabolic or mixed acidemia was associated with a mortality rate of 57% in the ICU. Delay of acidemia recovery as opposed to initial pH value was associated with increased mortality in the ICU. The type of acidemia did not influence the decision to administer sodium bicarbonate. The incidence of severe metabolic or mixed acidemia in critically ill patients was 6% in the present study, and it was associated with a 57% mortality rate in the ICU. In contradistinction with the initial acid-base parameters, the rapidity of acidemia recovery was an independent risk factor for mortality. Sodium bicarbonate prescription was very heterogeneous between ICUs. Further studies assessing specific treatments may be of interest in this population.

  8. Severe metabolic or mixed acidemia on intensive care unit admission: incidence, prognosis and administration of buffer therapy. a prospective, multiple-center study

    2011-01-01

    Introduction In this study, we sought describe the incidence and outcomes of severe metabolic or mixed acidemia in critically ill patients as well as the use of sodium bicarbonate therapy to treat these illnesses. Methods We conducted a prospective, observational, multiple-center study. Consecutive patients who presented with severe acidemia, defined herein as plasma pH below 7.20, were screened. The incidence, sodium bicarbonate prescription and outcomes of either metabolic or mixed severe acidemia were analyzed. Results Among 2, 550 critically ill patients, 200 (8%) presented with severe acidemia, and 155 (6% of the total admissions) met the inclusion criteria. Almost all patients needed mechanical ventilation and vasopressors during their ICU stay, and 20% of them required renal replacement therapy within the first 24 hours of their ICU stay. Severe metabolic or mixed acidemia was associated with a mortality rate of 57% in the ICU. Delay of acidemia recovery as opposed to initial pH value was associated with increased mortality in the ICU. The type of acidemia did not influence the decision to administer sodium bicarbonate. Conclusions The incidence of severe metabolic or mixed acidemia in critically ill patients was 6% in the present study, and it was associated with a 57% mortality rate in the ICU. In contradistinction with the initial acid-base parameters, the rapidity of acidemia recovery was an independent risk factor for mortality. Sodium bicarbonate prescription was very heterogeneous between ICUs. Further studies assessing specific treatments may be of interest in this population. PMID:21995879

  9. The impact of clinical research activities on communities in rural Africa: the development of the Clinical Research Unit of Nanoro (CRUN) in Burkina Faso.

    Tinto, Halidou; Valea, Innocent; Sorgho, Hermann; Tahita, Marc Christian; Traore, Maminata; Bihoun, Biébo; Guiraud, Issa; Kpoda, Hervé; Rouamba, Jérémi; Ouédraogo, Sayouba; Lompo, Palpouguini; Yara, Sandrine; Kabore, William; Ouédraogo, Jean-Bosco; Guiguemdé, Robert Tinga; Binka, Fred N; Ogutu, Bernhards

    2014-03-22

    The opportunities for developing new drugs and vaccines for malaria control look brighter now than ten years ago. However, there are few places in sub-Saharan Africa with the necessary infrastructure and expertise to support such research in compliance to international standards of clinical research (ICH-GCP). The Clinical Research Unit of Nanoro (CRUN) was founded in 2008 to provide a much-needed GCP-compliant clinical trial platform for an imminent large-scale Phase 3 malaria vaccine trial. A dynamic approach was used that entailed developing the required infrastructure and human resources, while engaging local communities in the process as key stakeholders. This provided a better understanding and ownership of the research activities by the local population. Within five years (2008-2013), the CRUN set up a fully and well-equipped GCP-compliant clinical trial research facility, which enabled to attract 25 grants. The research team grew from ten health workers prior to 2008 to 254 in 2013. A Health and Demographic Surveillance System (HDSS), which covers a total population of about 60,000 people in 24 villages was set up in the district. The local community contributed to the development of the facility through the leadership of the king and the mayor of Nanoro. As a result of their active advocacy, the government extended the national electrical grid to the new research center, and later to the entire village. This produced a positive impact on the community's quality of life. The quality of health care improved substantially, due to the creation of more elaborate clinical laboratory services and the acquisition of state-of-the-art equipment. Involving the community in the key steps of establishing the centre provided the foundation for what was to become the CRUN success story. This experience demonstrates that when clinical trials research sites are carefully developed and implemented, they can have a positive and powerful impact on local communities in

  10. Incentives for orphan drug research and development in the United States.

    Seoane-Vazquez, Enrique; Rodriguez-Monguio, Rosa; Szeinbach, Sheryl L; Visaria, Jay

    2008-12-16

    The Orphan Drug Act (1983) established several incentives to encourage the development of orphan drugs (ODs) to treat rare diseases and conditions. This study analyzed the characteristics of OD designations, approvals, sponsors, and evaluated the effective patent and market exclusivity life of orphan new molecular entities (NMEs) approved in the US between 1983 and 2007. Primary data sources were the FDA Orange Book, the FDA Office of Orphan Drugs Development, and the US Patent and Trademark Office. Data included all orphan designations and approvals listed by the FDA and all NMEs approved by the FDA during the study period. The FDA listed 1,793 orphan designations and 322 approvals between 1983 and 2007. Cancer was the main group of diseases targeted for orphan approvals. Eighty-three companies concentrated 67.7% of the total orphan NMEs approvals. The average time from orphan designation to FDA approval was 4.0 +/- 3.3 years (mean +/- standard deviation). The average maximum effective patent and market exclusivity life was 11.7 +/- 5.0 years for orphan NME. OD market exclusivity increased the average maximum effective patent and market exclusivity life of ODs by 0.8 years. Public programs, federal regulations, and policies support orphan drugs R&D. Grants, research design support, FDA fee waivers, tax incentives, and orphan drug market exclusivity are the main incentives for orphan drug R&D. Although the 7-year orphan drug market exclusivity provision had a positive yet relatively modest overall effect on effective patent and market exclusivity life, economic incentives and public support mechanisms provide a platform for continued orphan drug development for a highly specialized market.

  11. Advanced competencies mapping of critical care nursing: a qualitative research in two Intensive Care Units.

    Alfieri, Emanuela; Mori, Marina; Barbui, Valentina; Sarli, Leopoldo

    2017-07-18

    Nowadays, in Italy, the nursing profession has suffered important changes in response to the needs of citizens' health and to improve the quality of the health service in the country.  At the basis of this development there is an increase of the nurses' knowledge, competencies and responsibilities. Currently, the presence of nurses who have followed post-basic training paths, and the subsequent acquisition of advanced clinical knowledge and specializations, has made it essential for the presence of competencies mappings for each specialty, also to differentiate them from general care nurses. The objective is to get a mapping of nurse's individual competencies working in critical care, to analyze the context of the Parma Hospital and comparing it with the Lebanon Heart Hospital in Lebanon. The survey has been done through a series of interviews involving some of the hospital staff, in order to collect opinions about the ICU nurses' competencies. What emerged from the data allowed us to get a list of important abilities, competencies, character traits and  intensive care nurse activities. Italians and Lebanese nurses appear to be prepared from a technical point of view, with a desire for improvement through specializations, masters and enabling courses in advanced health maneuvers. By respondents nurses can seize a strong desire for professional improvement. At the end of our research we were able to draw a list of different individual competencies, behavioral and moral characteristics. The nurse figure has a high potential and large professional improvement prospects, if more taken into account by the health system.

  12. ASAS Centennial Paper: Impact of animal science research on United States goat production and predictions for the future.

    Sahlu, T; Dawson, L J; Gipson, T A; Hart, S P; Merkel, R C; Puchala, R; Wang, Z; Zeng, S; Goetsch, A L

    2009-01-01

    Goat research in the United States has increased but at a rate less than that in production. Research on goat meat includes nutritional quality, packaging, color, sensory characteristics, and preslaughter management. Goat skins have value for leather, but quality of goat leather has not been extensively studied. Research in the production, quality, antibiotic residues, and sensory characteristics of goat milk and its products has aided development of the US dairy goat industry. Limited progress has been made in genetic improvement of milk or meat production. There is need to explore applications of genomics and proteomics and improve consistency in texture and functionality of goat cheeses. New goat meat and milk products are needed to increase demand and meet the diverse tastes of the American public. Despite research progress in control of mohair and cashmere growth, erratic prices and sale of raw materials have contributed to further declines in US production. Innovative and cooperative ventures are needed for profit sharing up to the consumer level. Internal parasites pose the greatest challenge to goat production in humid areas largely because of anthelmintic resistance. Study of alternative controls is required, including immunity enhancement via nutrition, vaccination, pasture management such as co-grazing with cattle, and genetic resistance. Similarly, the importance of health management is increasing related in part to a lack of effective vaccines for many diseases. Nutrition research should address requirements for vitamins and minerals, efficiencies of protein utilization, adjusting energy requirements for nutritional plane, acclimatization, and grazing conditions, feed intake prediction, and management practices for rapid-growth production systems. Moreover, efficient technology transfer methods are needed to disseminate current knowledge and that gained in future research.

  13. Public Health System Research in Public Health Emergency Preparedness in the United States (2009-2015): Actionable Knowledge Base.

    Savoia, Elena; Lin, Leesa; Bernard, Dottie; Klein, Noah; James, Lyndon P; Guicciardi, Stefano

    2017-09-01

    In 2008, the Institute of Medicine released a letter report identifying 4 research priority areas for public health emergency preparedness in public health system research: (1) enhancing the usefulness of training, (2) improving timely emergency communications, (3) creating and maintaining sustainable response systems, and (4) generating effectiveness criteria and metrics. To (1) identify and characterize public health system research in public health emergency preparedness produced in the United States from 2009 to 2015, (2) synthesize research findings and assess the level of confidence in these findings, and (3) describe the evolution of knowledge production in public health emergency preparedness system research. Search Methods and Selection Criteria. We reviewed and included the titles and abstracts of 1584 articles derived from MEDLINE, EMBASE, and gray literature databases that focused on the organizational or financial aspects of public health emergency preparedness activities and were grounded on empirical studies. We included 156 articles. We appraised the quality of the studies according to the study design. We identified themes during article analysis and summarized overall findings by theme. We determined level of confidence in the findings with the GRADE-CERQual tool. Thirty-one studies provided evidence on how to enhance the usefulness of training. Results demonstrated the utility of drills and exercises to enhance decision-making capabilities and coordination across organizations, the benefit of cross-sector partnerships for successfully implementing training activities, and the value of integrating evaluation methods to support training improvement efforts. Thirty-six studies provided evidence on how to improve timely communications. Results supported the use of communication strategies that address differences in access to information, knowledge, attitudes, and practices across segments of the population as well as evidence on specific

  14. Metabolomics in nutrition research: assessment of metabolic status, response to treatment, and predictors of mortality in malnourished children

    Freemark, Michael

    2014-01-01

    OBJECTIVE: Malnutrition is a major cause of morbidity and mortality in infants and young children. To identify and target those at highest risk there is a critical need to elucidate the pathogenesis of severe acute childhood malnutrition and to characterize biomarkers that predict complications prior to and during treatment. METHODS: We applied targeted and non-targeted metabolomic analysis to characterize the hormonal and metabolic status of malnourished Ugandan infants and young children prior to and during nutritional therapy. Children ages 6mo-5yr were studied at presentation to Mulago Hospital and during inpatient therapy with milk-based formulas and outpatient supplementation with ready-to-use-food. We assessed the relationship between baseline hormone and metabolite levels and subsequent mortality. RESULTS: 77 patients were enrolled in the study; a subset was followed from inpatient treatment to outpatient clinic. Inpatient and outpatient therapies were associated with significant increases in weight/height z scores, but 12.2% of the children died during hospitalization. The levels of more than 100 metabolites were measured in samples of 1 ml of plasma. Treatment was accompanied by striking changes in the levels of fatty acids, amino acids, acylcarnitines, inflammatory cytokines, and various hormones including leptin, insulin, growth hormone, ghrelin, cortisol, IGF-1, GLP-1, and peptide YY. Multivariate regression analysis controlling for HIV and malarial infection identified a number of biochemical factors that were associated with, and may predict, mortality during treatment. CONCLUSIONS: Metabolomic analysis provides a comprehensive hormonal and metabolic profile of severely malnourished children prior to and during nutritional rehabilitation. Metabolomics can be used to identify biomarkers associated with mortality and may thereby facilitate the targeting and treatment of those at greatest risk. (author)

  15. Original Research: Metabolic alterations from early life thyroxine replacement therapy in male Ames dwarf mice are transient.

    Darcy, Justin; Fang, Yimin; Hill, Cristal M; McFadden, Sam; Sun, Liou Y; Bartke, Andrzej

    2016-10-01

    Ames dwarf mice are exceptionally long-lived due to a Prop1 loss of function mutation resulting in deficiency of growth hormone, thyroid-stimulating hormone and prolactin. Deficiency in thyroid-stimulating hormone and growth hormone leads to greatly reduced levels of circulating thyroid hormones and insulin-like growth factor 1, as well as a reduction in insulin secretion. Early life growth hormone replacement therapy in Ames dwarf mice significantly shortens their longevity, while early life thyroxine (T4) replacement therapy does not. Possible mechanisms by which early life growth hormone replacement therapy shortens longevity include deleterious effects on glucose homeostasis and energy metabolism, which are long lasting. A mechanism explaining why early life T4 replacement therapy does not shorten longevity remains elusive. Here, we look for a possible explanation as to why early life T4 replacement therapy does not impact longevity of Ames dwarf mice. We found that early life T4 replacement therapy increased body weight and advanced the age of sexual maturation. We also find that early life T4 replacement therapy does not impact glucose tolerance or insulin sensitivity, and any deleterious effects on oxygen consumption, respiratory quotient and heat production are transient. Lastly, we find that early life T4 replacement therapy has long-lasting effects on bone mineral density and bone mineral content. We suggest that the transient effects on energy metabolism and lack of effects on glucose homeostasis are the reasons why there is no shortening of longevity after early life T4 replacement therapy in Ames dwarf mice. © 2016 by the Society for Experimental Biology and Medicine.

  16. A tribute to Ulrich Heber (1930-2016) for his contribution to photosynthesis research: understanding the interplay between photosynthetic primary reactions, metabolism and the environment.

    Dietz, Karl-Josef; Krause, G Heinrich; Siebke, Katharina; Krieger-Liszkay, Anja

    2018-07-01

    The dynamic and efficient coordination of primary photosynthetic reactions with leaf energization and metabolism under a wide range of environmental conditions is a fundamental property of plants involving processes at all functional levels. The present historical perspective covers 60 years of research aiming to understand the underlying mechanisms, linking major breakthroughs to current progress. It centers on the contributions of Ulrich Heber who had pioneered novel concepts, fundamental methods, and mechanistic understanding of photosynthesis. An important first step was the development of non-aqueous preparation of chloroplasts allowing the investigation of chloroplast metabolites ex vivo (meaning that the obtained results reflect the in vivo situation). Later on, intact chloroplasts, retaining their functional envelope membranes, were isolated in aqueous media to investigate compartmentation and exchange of metabolites between chloroplasts and external medium. These studies elucidated metabolic interaction between chloroplasts and cytoplasm during photosynthesis. Experiments with isolated intact chloroplasts clarified that oxygenation of ribulose-1.5-bisphosphate generates glycolate in photorespiration. The development of non-invasive optical methods enabled researchers identifying mechanisms that balance electron flow in the photosynthetic electron transport system avoiding its over-reduction. Recording chlorophyll a (Chl a) fluorescence allowed one to monitor, among other parameters, thermal energy dissipation by means of 'nonphotochemical quenching' of the excited state of Chl a. Furthermore, studies both in vivo and in vitro led to basic understanding of the biochemical mechanisms of freezing damage and frost tolerance of plant leaves, to SO 2 tolerance of tree leaves and dehydrating lichens and mosses.

  17. Dentist Material Selection for Single-Unit Crowns: Findings from The National Dental Practice-Based Research Network

    Makhija, Sonia K.; Lawson, Nathaniel C.; Gilbert, Gregg H.; Litaker, Mark S.; McClelland, Jocelyn A.; Louis, David R.; Gordan, Valeria V.; Pihlstrom, Daniel J.; Meyerowitz, Cyril; Mungia, Rahma; McCracken, Michael S.

    2016-01-01

    Objectives Dentists enrolled in the National Dental Practice-Based Research Network completed a study questionnaire about techniques and materials used for single-unit crowns and an enrollment questionnaire about dentist/practice characteristics. The objectives were to quantify dentists’ material recommendations and test the hypothesis that dentist’s and practice’s characteristics are significantly associated with these recommendations. Methods Surveyed dentists responded to a contextual scenario asking what material they would use for a single-unit crown on an anterior and posterior tooth. Material choices included: full metal, porcelain-fused-to-metal (PFM), all-zirconia, layered zirconia, lithium disilicate, leucite-reinforced ceramic, or other. Results 1,777 of 2,132 eligible dentists responded (83%). The top 3 choices for anterior crowns were lithium disilicate (54%), layered zirconia (17%), and leucite-reinforced glass ceramic (13%). There were significant differences (p<0.05) by dentist’s gender, race, years since graduation, practice type, region, practice busyness, hours worked/week, and location type. The top 3 choices for posterior crowns were all-zirconia (32%), PFM (31%), and lithium disilicate (21%). There were significant differences (p<0.05) by dentist’s gender, practice type, region, practice busyness, insurance coverage, hours worked/week, and location type. Conclusions Network dentists use a broad range of materials for single-unit crowns for anterior and posterior teeth, adopting newer materials into their practices as they become available. Material choices are significantly associated with dentist’s and practice’s characteristics. Clinical Significance Decisions for crown material may be influenced by factors unrelated to tooth and patient variables. Dentists should be cognizant of this when developing an evidence-based approach to selecting crown material. PMID:27693778

  18. Possible stimuli for strength and power adaptation : acute metabolic responses.

    Crewther, Blair; Cronin, John; Keogh, Justin

    2006-01-01

    The metabolic response to resistance exercise, in particular lactic acid or lactate, has a marked influence upon the muscular environment, which may enhance the training stimulus (e.g. motor unit activation, hormones or muscle damage) and thereby contribute to strength and power adaptation. Hypertrophy schemes have resulted in greater lactate responses (%) than neuronal and dynamic power schemes, suggesting possible metabolic-mediated changes in muscle growth. Factors such as age, sex, training experience and nutrition may also influence the lactate responses to resistance exercise and thereafter, muscular adaptation. Although the importance of the mechanical and hormonal stimulus to strength and power adaptation is well recognised, the contribution of the metabolic stimulus is largely unknown. Relatively few studies for example, have examined metabolic change across neuronal and dynamic power schemes, and not withstanding the fact that those mechanisms underpinning muscular adaptation, in relation to the metabolic stimulus, remain highly speculative. Inconsistent findings and methodological limitations within research (e.g. programme design, sampling period, number of samples) make interpretation further difficult. We contend that strength and power research needs to investigate those metabolic mechanisms likely to contribute to weight-training adaptation. Further research is also needed to examine the metabolic responses to different loading schemes, as well as interactions across age, sex and training status, so our understanding of how to optimise strength and power development is improved.

  19. Gender-Based Violence Against Transgender People in the United States: A Call for Research and Programming.

    Wirtz, Andrea L; Poteat, Tonia C; Malik, Mannat; Glass, Nancy

    2018-01-01

    Gender-based violence (GBV) is an umbrella term for any harm that is perpetrated against a person's will and that results from power inequalities based on gender roles. Most global estimates of GBV implicitly refer only to the experiences of cisgender, heterosexually identified women, which often comes at the exclusion of transgender and gender nonconforming (trans) populations. Those who perpetrate violence against trans populations often target gender nonconformity, gender expression or identity, and perceived sexual orientation and thus these forms of violence should be considered within broader discussions of GBV. Nascent epidemiologic research suggests a high burden of GBV among trans populations, with an estimated prevalence that ranges from 7% to 89% among trans populations and subpopulations. Further, 165 trans persons have been reported murdered in the United States between 2008 and 2016. GBV is associated with multiple poor health outcomes and has been broadly posited as a component of syndemics, a term used to describe an interaction of diseases with underlying social forces, concomitant with limited prevention and response programs. The interaction of social stigma, inadequate laws, and punitive policies as well as a lack of effective GBV programs limits access to and use of GBV prevention and response programs among trans populations. This commentary summarizes the current body of research on GBV among trans populations and highlights areas for future research, intervention, and policy.

  20. Research

    abp

    2014-08-29

    Aug 29, 2014 ... Abstract. Introduction: metabolic syndrome and thyroid dysfunction are two common disorders encountered in the metabolic clinic. Recently, there has been increased interest in the association between the two disorders because of the similarities between symptoms of hypothyroidism and components of ...

  1. International topical meeting on research reactor fuel management (RRFM) - United States Foreign Research Reactor (FRR) Spent Nuclear Fuel (SNF) acceptance program: 2007 update

    Messick, C.E.; Taylor, J.L.

    2007-01-01

    The Nuclear Weapons Non-proliferation Policy Concerning Foreign Research Reactor Spent Nuclear Fuel, adopted by The United States Department of Energy (DOE), in consultation with the Department of State in May 1996, has been extended to expire May 12, 2016, providing an additional 10 years to return fuel to the U.S. This paper provides a brief update on the program, now transferred to the National Nuclear Security Administration (NNSA), and discusses program initiatives and future activities. The goal of the program continues to be recovery of nuclear materials (27 countries have participated so far, returning a total of 7620 spent nuclear fuel elements), which could otherwise be used in weapons, while assisting other countries to enjoy the benefits of nuclear technology. More than ever before, DOE and reactor operators need to work together to schedule shipments as soon as possible, to optimize shipment efficiency over the remaining years of the program. The NNSA is seeking feedback from research reactor operators to help us understand ways to include eligible reactor who have not yet participated in the program

  2. The NEIL Memory Research Unit: psychosocial, biological, physiological and lifestyle factors associated with healthy ageing: study protocol.

    Hannigan, Caoimhe; Coen, Robert F; Lawlor, Brian A; Robertson, Ian H; Brennan, Sabina

    2015-01-01

    Population ageing is a global phenomenon that has characterised demographic trends during the 20th and 21st century. The rapid growth in the proportion of older adults in the population, and resultant increase in the incidence of age-related cognitive decline, dementia and Alzheimer's disease, brings significant social, economic and healthcare challenges. Decline in cognitive abilities represents the most profound threat to active and healthy ageing. Current evidence suggests that a significant proportion of cases of age-related cognitive decline and dementia may be preventable through the modification of risk factors including education, depressive symptomology, physical activity, social engagement and participation in cognitively stimulating activities. The NEIL Memory Research Unit cohort study was established to investigate factors related to brain health and the maintenance of cognitive function. A cohort of 1000 normally ageing adults aged 50 years and over are being recruited to participate in comprehensive assessments at baseline, and at follow-up once every 2 years. The assessment protocol comprises a comprehensive neuropsychological battery, some basic physical measures, psychosocial scales, questionnaire measures related to a range of health, lifestyle and behavioural factors, and a measure of resting state activity using electroencephalography (EEG). The NEIL Memory Research Unit cohort study will address key questions about brain health and cognitive ageing in the population aged 50+, with a particular emphasis on the influence of potentially modifiable factors on cognitive outcomes. Analyses will be conducted with a focus on factors involved in the maintenance of cognitive function among older adults, and therefore will have the potential to contribute significant knowledge related to key questions within the field of cognitive ageing, and to inform the development of public health interventions aimed at preventing cognitive decline and promoting

  3. Expanding the TRI Network for Doctoral Researchers in the Fields of Terrorism, Political Violence and Armed Conflict to the United States of America and Russia

    Alex P. Schmid

    2011-12-01

    Full Text Available In September 2011, the Terrorism Research Initiative (TRI announced the creation of a post-graduate terrorism research network in the United Kingdom. The idea was to compile a list of post-graduates conducting research in the UK in the overlapping fields of terrorism, political violence, and armed conflict. While much research is conducted in these three overlapping fields, those involved in research are often unsure what is going on outside their own university department. They also wonder how their own work relates to current research developments elsewhere. To address these concerns, TRI has been inviting UK researchers to complete a profile form

  4. Effects of Timber Harvesting with Best Management Practices on Ecosystem Metabolism of a Low Gradient Stream on the United States Gulf Coastal Plain

    Abram DaSilva

    2013-06-01

    Full Text Available Stream metabolism can be used as a measure of freshwater ecosystem health because of its responsiveness to natural and anthropogenic changes. In this study, we used stream metabolic rates to test for the effects of a timber harvest with Louisiana’s current best management practices (BMPs. The study was conducted from 2006 to 2010 in a loblolly pine (Pinus taeda stand in north-central Louisiana, USA, 45 ha of which was clear cut harvested in the summer of 2007. Dissolved oxygen (DO, water temperature, and stream depth were recorded at a site upstream (serving as a reference and a site downstream of the harvested area. Using diurnal DO change and an open-system, single-station method at each site, we quantified rates of net ecosystem productivity (NEP, gross primary productivity (GPP, community respiration (CR, and the GPP/CR ratio. The system was predominately heterotrophic, with a GPP/CR ratio of less than one for 82% of the time at the upstream site. No calculated metabolic rate was significantly changed by the timber harvest (two-way ANOVA with interaction; p < 0.001. Overall, the results suggest that timber harvests of similar intensity with Louisiana’s current BMPs may not significantly impact stream biological conditions.

  5. Validation of the 'United Registries for Clinical Assessment and Research' [UR-CARE], a European Online Registry for Clinical Care and Research in Inflammatory Bowel Disease.

    Burisch, Johan; Gisbert, Javier P; Siegmund, Britta; Bettenworth, Dominik; Thomsen, Sandra Bohn; Cleynen, Isabelle; Cremer, Anneline; Ding, Nik John Sheng; Furfaro, Federica; Galanopoulos, Michail; Grunert, Philip Christian; Hanzel, Jurij; Ivanovski, Tamara Knezevic; Krustins, Eduards; Noor, Nurulamin; O'Morain, Neil; Rodríguez-Lago, Iago; Scharl, Michael; Tua, Julia; Uzzan, Mathieu; Ali Yassin, Nuha; Baert, Filip; Langholz, Ebbe

    2018-04-27

    The 'United Registries for Clinical Assessment and Research' [UR-CARE] database is an initiative of the European Crohn's and Colitis Organisation [ECCO] to facilitate daily patient care and research studies in inflammatory bowel disease [IBD]. Herein, we sought to validate the database by using fictional case histories of patients with IBD that were to be entered by observers of varying experience in IBD. Nineteen observers entered five patient case histories into the database. After 6 weeks, all observers entered the same case histories again. For each case history, 20 key variables were selected to calculate the accuracy for each observer. We assumed that the database was such that ≥ 90% of the entered data would be correct. The overall proportion of correctly entered data was calculated using a beta-binomial regression model to account for inter-observer variation and compared to the expected level of validity. Re-test reliability was assessed using McNemar's test. For all case histories, the overall proportion of correctly entered items and their confidence intervals included the target of 90% (Case 1: 92% [88-94%]; Case 2: 87% [83-91%]; Case 3: 93% [90-95%]; Case 4: 97% [94-99%]; Case 5: 91% [87-93%]). These numbers did not differ significantly from those found 6 weeks later [NcNemar's test p > 0.05]. The UR-CARE database appears to be feasible, valid and reliable as a tool and easy to use regardless of prior user experience and level of clinical IBD experience. UR-CARE has the potential to enhance future European collaborations regarding clinical research in IBD.

  6. Methodological approach in determination of small spatial units in a highly complex terrain in atmospheric pollution research: the case of Zasavje region in Slovenia.

    Kukec, Andreja; Boznar, Marija Z; Mlakar, Primoz; Grasic, Bostjan; Herakovic, Andrej; Zadnik, Vesna; Zaletel-Kragelj, Lijana; Farkas, Jerneja; Erzen, Ivan

    2014-05-01

    The study of atmospheric air pollution research in complex terrains is challenged by the lack of appropriate methodology supporting the analysis of the spatial relationship between phenomena affected by a multitude of factors. The key is optimal design of a meaningful approach based on small spatial units of observation. The Zasavje region, Slovenia, was chosen as study area with the main objective to investigate in practice the role of such units in a test environment. The process consisted of three steps: modelling of pollution in the atmosphere with dispersion models, transfer of the results to geographical information system software, and then moving on to final determination of the function of small spatial units. A methodology capable of designing useful units for atmospheric air pollution research in highly complex terrains was created, and the results were deemed useful in offering starting points for further research in the field of geospatial health.

  7. Sleep and Metabolism: An Overview

    Sunil Sharma

    2010-01-01

    Full Text Available Sleep and its disorders are increasingly becoming important in our sleep deprived society. Sleep is intricately connected to various hormonal and metabolic processes in the body and is important in maintaining metabolic homeostasis. Research shows that sleep deprivation and sleep disorders may have profound metabolic and cardiovascular implications. Sleep deprivation, sleep disordered breathing, and circadian misalignment are believed to cause metabolic dysregulation through myriad pathways involving sympathetic overstimulation, hormonal imbalance, and subclinical inflammation. This paper reviews sleep and metabolism, and how sleep deprivation and sleep disorders may be altering human metabolism.

  8. Toxic Hazards Research Unit

    1977-09-01

    greatly enlarged . Histologic examination of the neoplastic tissue growth was per- formed and a diagnosis made of reticulum cell sarcoma of multi...Guinea Pig Venipuncture femoral vein Venipuncture penis Dental exam Rodent Venipuncture tail vein Orbital sinus bleeding Heart Mark rodent using toe

  9. Martin Gibbs (1922-2006): Pioneer of (14)C research, sugar metabolism & photosynthesis; vigilant Editor-in-Chief of Plant Physiology; sage Educator; and humanistic Mentor.

    Black, Clanton C

    2008-01-01

    The very personal touch of Professor Martin Gibbs as a worldwide advocate for photosynthesis and plant physiology was lost with his death in July 2006. Widely known for his engaging humorous personality and his humanitarian lifestyle, Martin Gibbs excelled as a strong international science diplomat; like a personal science family patriarch encouraging science and plant scientists around the world. Immediately after World War II he was a pioneer at the Brookhaven National Laboratory in the use of (14)C to elucidate carbon flow in metabolism and particularly carbon pathways in photosynthesis. His leadership on carbon metabolism and photosynthesis extended for four decades of working in collaboration with a host of students and colleagues. In 1962, he was selected as the Editor-in-Chief of Plant Physiology. That appointment initiated 3 decades of strong directional influences by Gibbs on plant research and photosynthesis. Plant Physiology became and remains a premier source of new knowledge about the vital and primary roles of plants in earth's environmental history and the energetics of our green-blue planet. His leadership and charismatic humanitarian character became the quintessence of excellence worldwide. Martin Gibbs was in every sense the personification of a model mentor not only for scientists but also shown in devotion to family. Here we pay tribute and honor to an exemplary humanistic mentor, Martin Gibbs.

  10. Metabolic Syndrome

    Metabolic syndrome is a group of conditions that put you at risk for heart disease and diabetes. These conditions ... agree on the definition or cause of metabolic syndrome. The cause might be insulin resistance. Insulin is ...

  11. Making Social Work Count: A Curriculum Innovation to Teach Quantitative Research Methods and Statistical Analysis to Undergraduate Social Work Students in the United Kingdom

    Teater, Barbra; Roy, Jessica; Carpenter, John; Forrester, Donald; Devaney, John; Scourfield, Jonathan

    2017-01-01

    Students in the United Kingdom (UK) are found to lack knowledge and skills in quantitative research methods. To address this gap, a quantitative research method and statistical analysis curriculum comprising 10 individual lessons was developed, piloted, and evaluated at two universities The evaluation found that BSW students' (N = 81)…

  12. Sleep and Metabolism: An Overview

    Sharma, Sunil; Kavuru, Mani

    2010-01-01

    Sleep and its disorders are increasingly becoming important in our sleep deprived society. Sleep is intricately connected to various hormonal and metabolic processes in the body and is important in maintaining metabolic homeostasis. Research shows that sleep deprivation and sleep disorders may have profound metabolic and cardiovascular implications. Sleep deprivation, sleep disordered breathing, and circadian misalignment are believed to cause metabolic dysregulation through myriad pathways i...

  13. Overview of the United States department of energy's used fuel disposition research and development campaign

    Nutt, Mark [Argonne National Laboratory, Argonne, IL (United States); Swift, Peter; MacKinnon, Robert; McMahon, Kevin; Sorenson, Ken [Sandia National Laboratories, Albuquerque NM (United States); Birkholzer, Jens [Lawrence Berkeley National Laboratory, Berkeley, CA (United States); Boyle, William; Gunter, Timothy; Larson, Ned [U.S. Department of Energy, Las Vegas, NV (United States)

    2013-07-01

    The United States Department of Energy (US DOE) is conducting research and development (R and D) activities within the Used Fuel Disposition Campaign (UFDC) to support storage, transportation, and disposal of used nuclear fuel (UNF) and wastes generated by existing and future nuclear fuel cycles. R and D activities are ongoing at nine national laboratories, and are divided into two major topical areas: (1) storage and transportation research, and (2) disposal research. Storage R and D focuses on closing technical gaps related to extended storage of UNF. For example, uncertainties remain regarding high-burnup nuclear fuel cladding performance following possible hydride reorientation and creep deformation, and also regarding long-term canister integrity. Transportation R and D focuses on ensuring transportability of UNF following extended storage, addressing data gaps regarding nuclear fuel integrity, retrievability, and demonstration of subcriticality. Disposal R and D focuses on identifying multiple viable geologic disposal options and addressing technical challenges for generic disposal concepts in various host media (e.g., mined repositories in salt, clay/shale, and granitic rocks, and deep borehole disposal in crystalline rock). R and D will transition to site-specific challenges as national policy advances. R and D goals at this stage are to increase confidence in the robustness of generic disposal concepts, to reduce generic sources of uncertainty that may impact the viability of disposal concepts, and to develop science and engineering tools that will support the selection, characterization, and ultimately licensing of a repository. The US DOE has also initiated activities that can be conducted within the constraints of the Nuclear Waste Policy Act to facilitate the development of an interim storage facility and supporting transportation infrastructure. (authors)

  14. External validation of the Intensive Care National Audit & Research Centre (ICNARC) risk prediction model in critical care units in Scotland.

    Harrison, David A; Lone, Nazir I; Haddow, Catriona; MacGillivray, Moranne; Khan, Angela; Cook, Brian; Rowan, Kathryn M

    2014-01-01

    Risk prediction models are used in critical care for risk stratification, summarising and communicating risk, supporting clinical decision-making and benchmarking performance. However, they require validation before they can be used with confidence, ideally using independently collected data from a different source to that used to develop the model. The aim of this study was to validate the Intensive Care National Audit & Research Centre (ICNARC) model using independently collected data from critical care units in Scotland. Data were extracted from the Scottish Intensive Care Society Audit Group (SICSAG) database for the years 2007 to 2009. Recoding and mapping of variables was performed, as required, to apply the ICNARC model (2009 recalibration) to the SICSAG data using standard computer algorithms. The performance of the ICNARC model was assessed for discrimination, calibration and overall fit and compared with that of the Acute Physiology And Chronic Health Evaluation (APACHE) II model. There were 29,626 admissions to 24 adult, general critical care units in Scotland between 1 January 2007 and 31 December 2009. After exclusions, 23,269 admissions were included in the analysis. The ICNARC model outperformed APACHE II on measures of discrimination (c index 0.848 versus 0.806), calibration (Hosmer-Lemeshow chi-squared statistic 18.8 versus 214) and overall fit (Brier's score 0.140 versus 0.157; Shapiro's R 0.652 versus 0.621). Model performance was consistent across the three years studied. The ICNARC model performed well when validated in an external population to that in which it was developed, using independently collected data.

  15. Treatment Recommendations for Single-Unit Crowns: Findings from The National Dental Practice-Based Research Network

    McCracken, Michael S.; Louis, David R.; Litaker, Mark S.; Minyé, Helena M.; Mungia, Rahma; Gordan, Valeria V.; Marshall, Don G.; Gilbert, Gregg H.

    2016-01-01

    Background Objectives were to: (1) quantify practitioner variation in likelihood to recommend a crown; and (2) test whether certain dentist, practice, and clinical factors are significantly associated with this likelihood. Methods Dentists in the National Dental Practice-Based Research Network completed a questionnaire about indications for single-unit crowns. In four clinical scenarios, practitioners ranked their likelihood of recommending a single-unit crown. These responses were used to calculate a dentist-specific “Crown Factor” (CF; range 0–12). A higher score implies a higher likelihood to recommend a crown. Certain characteristics were tested for statistically significant associations with the CF. Results 1,777 of 2,132 eligible dentists responded (83%). Practitioners were most likely to recommend crowns for teeth that were fractured, cracked, endodontically-treated, or had a broken restoration. Practitioners overwhelmingly recommended crowns for posterior teeth treated endodontically (94%). Practice owners, Southwest practitioners, and practitioners with a balanced work load were more likely to recommend crowns, as were practitioners who use optical scanners for digital impressions. Conclusions There is substantial variation in the likelihood of recommending a crown. While consensus exists in some areas (posterior endodontic treatment), variation dominates in others (size of an existing restoration). Recommendations varied by type of practice, network region, practice busyness, patient insurance status, and use of optical scanners. Practical Implications Recommendations for crowns may be influenced by factors unrelated to tooth and patient variables. A concern for tooth fracture -- whether from endodontic treatment, fractured teeth, or large restorations -- prompted many clinicians to recommend crowns. PMID:27492046

  16. Survey of brachytherapy practice in the United States: a report of the Clinical Research Committee of the American Endocurietherapy Society.

    Nag, S; Owen, J B; Farnan, N; Pajak, T F; Martinez, A; Porter, A; Blasko, J; Harrison, L B

    1995-01-01

    To obtain reliable data on the extent of the brachytherapy practice in the United States by conducting a comprehensive survey of all facilities. The Clinical Research Committee of the AES surveyed all 1321 radiation oncology facilities identified in the Patterns of Care Study (PCS) of the American College of Radiology (ACR). Multiple mailings and follow-up were made to obtain a high response rate. Survey responders and nonresponders were compared using chi-square tests. Summary statistics were reported. Of the 1321 facilities, 1054 responded (80%). Hospital-based and larger facilities had a statistically significant higher rate of response. Brachytherapy was being performed at 819 facilities (the median number of procedures = 21-50). Two hundred and two facilities did no brachytherapy. The common isotopes used were 137Cs (705 facilities), 192Ir (585 facilities), 125I (236 facilities), and 131I (194 facilities). The common brachytherapy techniques used were intracavitary (751 facilities), interstitial (536 facilities), intraluminal (310 facilities), and plaques (148 facilities). Remote afterloaded brachytherapy was used at 205 centers as follows: high dose rate (HDR) (164), medium dose rate (MDR) (5), and low dose rate (LDR) (36). Computerized dosimetry was most commonly used (790 facilities), followed by Patterson-Parker (104 facilities) and Quimby (72 facilities). The common sites treated were cervix (701 facilities), endometrium (565 facilities), head and neck (354 facilities), and lung (344 facilities). Data regarding brachytherapy practice has been obtained from a large percentage (80%) of all facilities in the United States. The majority (78-81%) of radiation oncology facilities perform brachytherapy; however, its use is restricted to gynecological implants in many of these centers. The results from this survey will be used to develop a pattern of care study and data registry in brachytherapy.

  17. Understanding arsenic metabolism through a comparative study of arsenic levels in the urine, hair and fingernails of healthy volunteers from three unexposed ethnic groups in the United Kingdom

    Brima, Eid I.; Haris, Parvez I.; Jenkins, Richard O.; Polya, Dave A.; Gault, Andrew G.; Harrington, Chris F.

    2006-01-01

    Very little is known about arsenic (As) metabolism in healthy populations that are not exposed to high concentrations of As in their food or water. Here we present a study with healthy volunteers from three different ethnic groups, residing in Leicester, UK, which reveals statistically significant differences in the levels of total As in urine and fingernail samples. Urine (n = 63), hair (n = 36) and fingernail (n = 36) samples from Asians, Somali Black-Africans and Whites were analysed using inductively coupled plasma mass spectrometry (ICP-MS) and graphite furnace atomic absorption spectroscopy (GF-AAS). The results clearly show that the total concentrations of As in urine and fingernail samples of a Somali Black-African population (urine 7.2 μg/g creatinine; fingernails 723.1 μg/kg) are significantly (P 0.05) in the level of As in the hair samples from these three groups; Somali Black-Africans (116.0 μg/kg), Asians (117.4 μg/kg) and Whites (141.2 μg/kg). Significantly different levels of total As in fingernail and urine and a higher percentage of urinary DMA in the Somali Black-Africans are suggestive of a different pattern of As metabolism in this ethnic group

  18. Metabolic syndrome in chronic hepatitis C infection: does it still matter in the era of directly acting antiviral therapy?

    Lim TR

    2014-12-01

    Full Text Available TR Lim Centre for Liver Research and NIHR Biomedical Research Unit in Liver Disease, University of Birmingham and Liver and Hepatobiliary Unit, Queen Elizabeth Hospital Birmingham, UK Abstract: Metabolic syndrome is prevalent in patients with hepatitis C virus (HCV infection. Given the pandemic spread of HCV infection and metabolic syndrome, the burden of their interaction is a major public health issue. The presence of metabolic syndrome accelerates the progression of liver disease in patients with HCV infection. New drug development in HCV has seen an unprecedented rise in the last year, which resulted in better efficacy, better tolerance, and a shorter treatment duration. This review describes the underlying mechanisms and clinical effects of metabolic syndrome in HCV infection, as well as their importance in the era of new directly acting antiviral therapy. Keywords: HCV, genotype 3, metabolic syndrome, steatosis, directly acting antiviral agents

  19. Metabolic Engineering VII Conference

    Kevin Korpics

    2012-12-04

    The aims of this Metabolic Engineering conference are to provide a forum for academic and industrial researchers in the field; to bring together the different scientific disciplines that contribute to the design, analysis and optimization of metabolic pathways; and to explore the role of Metabolic Engineering in the areas of health and sustainability. Presentations, both written and oral, panel discussions, and workshops will focus on both applications and techniques used for pathway engineering. Various applications including bioenergy, industrial chemicals and materials, drug targets, health, agriculture, and nutrition will be discussed. Workshops focused on technology development for mathematical and experimental techniques important for metabolic engineering applications will be held for more in depth discussion. This 2008 meeting will celebrate our conference tradition of high quality and relevance to both industrial and academic participants, with topics ranging from the frontiers of fundamental science to the practical aspects of metabolic engineering.

  20. Metabolic imaging using PET

    Kudo, Takashi

    2007-01-01

    There is growing evidence that myocardial metabolism plays a key role not only in ischaemic heart disease but also in a variety of diseases which involve myocardium globally, such as heart failure and diabetes mellitus. Understanding myocardial metabolism in such diseases helps to elucidate the pathophysiology and assists in making therapeutic decisions. As well as providing information on regional changes, PET can deliver quantitative information about both regional and global changes in metabolism. This capability of quantitative measurement is one of the major advantages of PET along with physiological positron tracers, especially relevant in evaluating diseases which involve the whole myocardium. This review discusses major PET tracers for metabolic imaging and their clinical applications and contributions to research regarding ischaemic heart disease and other diseases such as heart failure and diabetic heart disease. Future applications of positron metabolic tracers for the detection of vulnerable plaque are also highlighted briefly. (orig.)

  1. INDEPENDENT TECHNICAL ASSESSMENT OF MANAGEMENT OF STORMWATER AND WASTEWATER AT THE SEPARATIONS PROCESS RESEARCH UNIT (SPRU) DISPOSITION PROJECT, NEW YORK

    Abitz, R.; Jackson, D.; Eddy-Dilek, C.

    2011-06-27

    The U.S. Department of Energy (DOE) is currently evaluating the water management procedures at the Separations Process Research Unit (SPRU). The facility has three issues related to water management that require technical assistance: (1) due to a excessive rainfall event in October, 2010, contaminated water collected in basements of G2 and H2 buildings. As a result of this event, the contractor has had to collect and dispose of water offsite; (2) The failure of a sump pump at a KAPL outfall resulted in a Notice of Violation issued by the New York State Department of Environment and Conservation (NYSDEC) and subsequent Consent Order. On-site water now requires treatment and off-site disposition; and (3) stormwater infiltration has resulted in Strontium-90 levels discharged to the storm drains that exceed NR standards. The contractor has indicated that water management at SPRU requires major staff resources (at least 50 persons). The purpose of this review is to determine if the contractor's technical approach warrants the large number of staff resources and to ensure that the technical approach is compliant and in accordance with federal, state and NR requirements.

  2. Transport of HIFAR spent fuel from Lucas Heights Research Establishment to the United Kingdom for reprocessing. Public Environmental Report

    NONE

    1995-10-27

    The normal operations of HIFAR produce thirty-eight spent fuel elements annually. Since 1958, when operations began, 1,660 spent fuel elements have been accumulated and are stored in ANSTO`s engineered interim storage facilities at Lucas Heights. In the light of the limited size of these storage facilities and following the Research Reactor Review (1993) and an Inter-Agency Review, the Commonwealth Government announced its decision to reduce the number of spent fuel elements stored at the site. Therefore, ANSTO has been authorised to negotiate the terms for shipment of spent fuel elements of United Kingdom (UK) origin to the Dounreay reprocessing plant in Scotland. This Public Environment Report, prepared under the Environment Protection (Impact of Proposals) Act 1974, describes the potential impacts and risks of a proposed initial shipment of 120 spent fuel elements to the Dounreay reprocessing plant. It describes the intended packaging and transport procedures and considers possible alternative methods of dealing with the continued production of spent fuel rods and the limited storage capacity at LHRL. The exhaustive analysis of every phase of operations involved in the shipping of a cask of spent HIFAR fuel elements from Lucas Heights to Dounreay, for reprocessing, has shown that there are no significant environmental or public health impacts from such a shipment conducted in accordance with standard, internationally established procedures. 18 refs., 12 tabs., 2 figs.

  3. Solar energy development and aquatic ecosystems in the southwestern United States: potential impacts, mitigation, and research needs.

    Grippo, Mark; Hayse, John W; O'Connor, Ben L

    2015-01-01

    The cumulative impacts of utility-scale solar energy facilities on aquatic ecosystems in the Southwestern United States are of concern, considering the many existing regional anthropogenic stressors. We review the potential impacts of solar energy development on aquatic habitat and biota. The greatest potential for impacts is related to the loss, fragmentation, or prolonged drying of ephemeral water bodies and drainage networks resulting from the loss of desert washes within the construction footprint of the facility. Groundwater-dependent aquatic habitat may also be affected by operational groundwater withdrawal in the case of water-intensive solar technologies. Solar panels have also been found to attract aquatic insects and waterbirds, potentially resulting in mortality. Avoiding construction activity near perennial and intermittent surface waters is the primary means of reducing impacts on aquatic habitats, followed by measures to minimize erosion, sedimentation, and contaminant inputs into waterways. Currently, significant data gaps make solar facility impact assessment and mitigation more difficult. Examples include the need for more regional and site-specific studies of surface-groundwater connectivity, more detailed maps of regional stream networks and riparian vegetation corridors, as well as surveys of the aquatic communities inhabiting ephemeral streams. In addition, because they often lack regulatory protection, there is also a need to develop valuation criteria for ephemeral waters based on their ecological and hydrologic function within the landscape. By addressing these research needs, we can achieve the goal of greater reliance on solar energy, while at the same time minimizing impacts on desert ecosystems.

  4. Transport of HIFAR spent fuel from Lucas Heights Research Establishment to the United Kingdom for reprocessing. Public Environmental Report

    1995-01-01

    The normal operations of HIFAR produce thirty-eight spent fuel elements annually. Since 1958, when operations began, 1,660 spent fuel elements have been accumulated and are stored in ANSTO's engineered interim storage facilities at Lucas Heights. In the light of the limited size of these storage facilities and following the Research Reactor Review (1993) and an Inter-Agency Review, the Commonwealth Government announced its decision to reduce the number of spent fuel elements stored at the site. Therefore, ANSTO has been authorised to negotiate the terms for shipment of spent fuel elements of United Kingdom (UK) origin to the Dounreay reprocessing plant in Scotland. This Public Environment Report, prepared under the Environment Protection (Impact of Proposals) Act 1974, describes the potential impacts and risks of a proposed initial shipment of 120 spent fuel elements to the Dounreay reprocessing plant. It describes the intended packaging and transport procedures and considers possible alternative methods of dealing with the continued production of spent fuel rods and the limited storage capacity at LHRL. The exhaustive analysis of every phase of operations involved in the shipping of a cask of spent HIFAR fuel elements from Lucas Heights to Dounreay, for reprocessing, has shown that there are no significant environmental or public health impacts from such a shipment conducted in accordance with standard, internationally established procedures. 18 refs., 12 tabs., 2 figs

  5. A RWMAC commentary on the Science Policy Research Unit Report: UK Nuclear Decommissioning Policy: time for decision

    Anon.

    1994-04-01

    The Radioactive Waste Management Advisory Committee (RWMAC) is an independent body which advises the Secretaries of State for the Environment, Scotland and Wales, on civil radioactive waste management issues. Chapter 4 of the RWMAC's Twelfth Annual Report discussed nuclear power plant decommissioning strategy. One of the RWMAC's conclusions was that the concept of financial provisioning for power station decommissioning liabilities, which might be passed on to society several generations into the future, deserved further study. A specification for such a study was duly written (Annex 2) and, following consideration of tendered responses, the Science Policy Research Unit (SPRU) at Sussex University, was contracted to carry out the work. The SPRU report stands as a SPRU analysis of the subject. This separate short RWMAC report, which is being released at the same time as the SPRU report, presents the RWMAC's own commentary on the SPRU study. The RWMAC has identified five main issues which should be addressed when deciding on a nuclear plant decommissioning strategy. These are: the technical approach to decommissioning, the basis of financial provisions, treatment of risk, segregation of management of funds, and the need for a wider environmental view. (author)

  6. A RWMAC commentary on the Science Policy Research Unit report: UK nuclear decommissioning policy: time for decision

    1994-04-01

    Chapter 4 of the RWMAC's Twelfth Annual Report discussed nuclear power plant decommissioning strategy. One of the RWMAC's conclusions was that the concept of financial provisioning for power station decommissioning liabilities, which might be passed on to society several generations into the future, deserved further study. A specification for such a study was duly written (Annex 2) and, following consideration of tendered responses, the Science Policy Research Unit (SPRU) at Sussex University, was contracted to carry out the work. The SPRU report stands as a SPRU analysis of the subject. This separate short RWMAC report, which is being released at the same time as the SPRU report, presents the RWMAC's own commentary on the SPRU study. The RWMAC has identified five main issues which should be addressed when deciding on a nuclear plant decommissioning strategy. These are: the technical approach to decommissioning, the basis of financial provisions, treatment of risk, segregation of management of funds, and the need for a wider environmental view. These issues are addressed in this RWMAC report. (author)

  7. NIH Mouse Metabolic Phenotyping Centers: the power of centralized phenotyping.

    Laughlin, Maren R; Lloyd, K C Kent; Cline, Gary W; Wasserman, David H

    2012-10-01

    The Mouse Metabolic Phenotyping Centers (MMPCs) were founded in 2001 by the National Institutes of Health (NIH) to advance biomedical research by providing the scientific community with standardized, high-quality phenotyping services for mouse models of diabetes, obesity, and their complications. The intent is to allow researchers to take optimum advantage of the many new mouse models produced in labs and in high-throughput public efforts. The six MMPCs are located at universities around the country and perform complex metabolic tests in intact mice and hormone and analyte assays in tissues on a fee-for-service basis. Testing is subsidized by the NIH in order to reduce the barriers for mouse researchers. Although data derived from these tests belong to the researcher submitting mice or tissues, these data are archived after publication in a public database run by the MMPC Coordinating and Bioinformatics Unit. It is hoped that data from experiments performed in many mouse models of metabolic diseases, using standard protocols, will be useful in understanding the nature of these complex disorders. The current areas of expertise include energy balance and body composition, insulin action and secretion, whole-body and tissue carbohydrate and lipid metabolism, cardiovascular and renal function, and metabolic pathway kinetics. In addition to providing services, the MMPC staff provides expertise and advice to researchers, and works to develop and refine test protocols to best meet the community's needs in light of current scientific developments. Test technology is disseminated by publications and through annual courses.

  8. Advanced Stirling Convertor Control Unit Testing at NASA Glenn Research Center in the Radioisotope Power Systems System Integration Laboratory

    Dugala, Gina M.; Taylor, Linda M.; Kussmaul, Michael; Casciani, Michael; Brown, Gregory; Wiser, Joel

    2017-01-01

    Future NASA missions could include establishing Lunar or Martian base camps, exploring Jupiters moons and travelling beyond where generating power from sunlight may be limited. Radioisotope Power Systems (RPS) provide a dependable power source for missions where inadequate sunlight or operational requirements make other power systems impractical. Over the past decade, NASA Glenn Research Center (GRC) has been supporting the development of RPSs. The Advanced Stirling Radioisotope Generator (ASRG) utilized a pair of Advanced Stirling Convertors (ASC). While flight development of the ASRG has been cancelled, much of the technology and hardware continued development and testing to guide future activities. Specifically, a controller for the convertor(s) is an integral part of a Stirling-based RPS. For the ASRG design, the controller maintains stable operation of the convertors, regulates the alternating current produced by the linear alternator of the convertor, provides a specified direct current output voltage for the spacecraft, synchronizes the piston motion of the two convertors in order to minimize vibration as well as manage and maintain operation with a stable piston amplitude and hot end temperature. It not only provides power to the spacecraft but also must regulate convertor operation to avoid damage to internal components and maintain safe thermal conditions after fueling. Lockheed Martin Coherent Technologies has designed, developed and tested an Engineering Development Unit (EDU) Advanced Stirling Convertor Control Unit (ACU) to support this effort. GRC used the ACU EDU as part of its non-nuclear representation of a RPS which also consists of a pair of Dual Advanced Stirling Convertor Simulator (DASCS), and associated support equipment to perform a test in the Radioisotope Power Systems System Integration Laboratory (RSIL). The RSIL was designed and built to evaluate hardware utilizing RPS technology. The RSIL provides insight into the electrical

  9. VRML metabolic network visualizer.

    Rojdestvenski, Igor

    2003-03-01

    A successful date collection visualization should satisfy a set of many requirements: unification of diverse data formats, support for serendipity research, support of hierarchical structures, algorithmizability, vast information density, Internet-readiness, and other. Recently, virtual reality has made significant progress in engineering, architectural design, entertainment and communication. We experiment with the possibility of using the immersive abstract three-dimensional visualizations of the metabolic networks. We present the trial Metabolic Network Visualizer software, which produces graphical representation of a metabolic network as a VRML world from a formal description written in a simple SGML-type scripting language.

  10. Dysregulated metabolism contributes to oncogenesis

    Hirschey, Matthew D.; DeBerardinis, Ralph J.; Diehl, Anna Mae E.; Drew, Janice E.; Frezza, Christian; Green, Michelle F.; Jones, Lee W.; Ko, Young H.; Le, Anne; Lea, Michael A.; Locasale, Jason W.; Longo, Valter D.; Lyssiotis, Costas A.; McDonnell, Eoin; Mehrmohamadi, Mahya; Michelotti, Gregory; Muralidhar, Vinayak; Murphy, Michael P.; Pedersen, Peter L.; Poore, Brad; Raffaghello, Lizzia; Rathmell, Jeffrey C.; Sivanand, Sharanya; Vander Heiden, Matthew G.; Wellen, Kathryn E.

    2015-01-01

    Cancer is a disease characterized by unrestrained cellular proliferation. In order to sustain growth, cancer cells undergo a complex metabolic rearrangement characterized by changes in metabolic pathways involved in energy production and biosynthetic processes. The relevance of the metabolic transformation of cancer cells has been recently included in the updated version of the review “Hallmarks of Cancer”, where the dysregulation of cellular metabolism was included as an emerging hallmark. While several lines of evidence suggest that metabolic rewiring is orchestrated by the concerted action of oncogenes and tumor suppressor genes, in some circumstances altered metabolism can play a primary role in oncogenesis. Recently, mutations of cytosolic and mitochondrial enzymes involved in key metabolic pathways have been associated with hereditary and sporadic forms of cancer. Together, these results suggest that aberrant metabolism, once seen just as an epiphenomenon of oncogenic reprogramming, plays a key role in oncogenesis with the power to control both genetic and epigenetic events in cells. In this review, we discuss the relationship between metabolism and cancer, as part of a larger effort to identify a broad-spectrum of therapeutic approaches. We focus on major alterations in nutrient metabolism and the emerging link between metabolism and epigenetics. Finally, we discuss potential strategies to manipulate metabolism in cancer and tradeoffs that should be considered. More research on the suite of metabolic alterations in cancer holds the potential to discover novel approaches to treat it. PMID:26454069

  11. Genetic screening: programs, principles, and research--thirty years later. Reviewing the recommendations of the Committee for the Study of Inborn Errors of Metabolism (SIEM).

    Simopoulos, A P

    2009-01-01

    Screening programs for genetic diseases and characteristics have multiplied in the last 50 years. 'Genetic Screening: Programs, Principles, and Research' is the report of the Committee for the Study of Inborn Errors of Metabolism (SIEM Committee) commissioned by the Division of Medical Sciences of the National Research Council at the National Academy of Sciences in Washington, DC, published in 1975. The report is considered a classic in the field worldwide, therefore it was thought appropriate 30 years later to present the Committee's modus operandi and bring the Committee's recommendations to the attention of those involved in genetics, including organizational, educational, legal, and research aspects of genetic screening. The Committee's report anticipated many of the legal, ethical, economic, social, medical, and policy aspects of genetic screening. The recommendations are current, and future committees should be familiar with them. In 1975 the Committee stated: 'As new screening tests are devised, they should be carefully reviewed. If the experimental rate of discovery of new genetic characteristics means an accelerating rate of appearance of new screening tests, now is the time to develop the medical and social apparatus to accommodate what later on may otherwise turn out to be unmanageable growth.' What a prophetic statement that was. If the Committee's recommendations had been implemented on time, there would be today a federal agency in existence, responsive and responsible to carry out the programs and support research on various aspects of genetic screening, including implementation of a federal law that protects consumers from discrimination by their employers and the insurance industry on the basis of genetic information. Copyright 2008 S. Karger AG, Basel.

  12. Compilation of anatomical, physiological and metabolic characteristics for a Reference Asian Man. Volume 2: Country reports. Results of a co-ordinated research programme 1988-1993

    1998-02-01

    The coordinated Research Programme (CRP) on Compilation of Anatomical, Physiological and Metabolic Characteristics for a Reference Asian Man has been conducted as a programme of the IAEA Regional Co-operative Agreement (RCA) for Asia and the Pacific. The CRP was conducted to provide data for radiation protection purposes that is relevant to the biokinetic and dosimetric characteristics of the ethnic populations in the Asian region The radiological protection decisions that had to be made in the RCA member States following the Chernobyl accident were a significant motivation for establishing the CRP. Funding for the RCM by the Government of Japan is gratefully acknowledged. The IAEA wishes to thank S. Kobayashi for his efforts in support of the CRP. The IAEA extends its appreciation to the Japanese National Institute of Radiological Sciences for acting as the technical secretariat to co-ordinate the work of data compilation. Specifically, the IAEA acknowledges the contributions of H. Kawamura, G. Tanaka and T. Koyanagi. Appreciation is also extended to the National Institute of Radiological Sciences, Japan, the Bhabha Atomic Research Centre, India, and the Chinese Academy of Medical Sciences for the valuable contribution they made to the CRP as hosts for the RCMS. The IAEA officers responsible for this publication were A. Moiseev and R.V. Griffith of the Division of Radiation and Waste Safety. This publication is divided into two volumes: Volume 1 contains a summary of the data and conclusions from the project and Volume 2 the reports from participating countries

  13. A roadmap for research on crassulacean acid metabolism (CAM) to enhance sustainable food and bioenergy production in a hotter, drier world.

    Yang, Xiaohan; Cushman, John C; Borland, Anne M; Edwards, Erika J; Wullschleger, Stan D; Tuskan, Gerald A; Owen, Nick A; Griffiths, Howard; Smith, J Andrew C; De Paoli, Henrique C; Weston, David J; Cottingham, Robert; Hartwell, James; Davis, Sarah C; Silvera, Katia; Ming, Ray; Schlauch, Karen; Abraham, Paul; Stewart, J Ryan; Guo, Hao-Bo; Albion, Rebecca; Ha, Jungmin; Lim, Sung Don; Wone, Bernard W M; Yim, Won Cheol; Garcia, Travis; Mayer, Jesse A; Petereit, Juli; Nair, Sujithkumar S; Casey, Erin; Hettich, Robert L; Ceusters, Johan; Ranjan, Priya; Palla, Kaitlin J; Yin, Hengfu; Reyes-García, Casandra; Andrade, José Luis; Freschi, Luciano; Beltrán, Juan D; Dever, Louisa V; Boxall, Susanna F; Waller, Jade; Davies, Jack; Bupphada, Phaitun; Kadu, Nirja; Winter, Klaus; Sage, Rowan F; Aguilar, Cristobal N; Schmutz, Jeremy; Jenkins, Jerry; Holtum, Joseph A M

    2015-08-01

    Crassulacean acid metabolism (CAM) is a specialized mode of photosynthesis that features nocturnal CO2 uptake, facilitates increased water-use efficiency (WUE), and enables CAM plants to inhabit water-limited environments such as semi-arid deserts or seasonally dry forests. Human population growth and global climate change now present challenges for agricultural production systems to increase food, feed, forage, fiber, and fuel production. One approach to meet these challenges is to increase reliance on CAM crops, such as Agave and Opuntia, for biomass production on semi-arid, abandoned, marginal, or degraded agricultural lands. Major research efforts are now underway to assess the productivity of CAM crop species and to harness the WUE of CAM by engineering this pathway into existing food, feed, and bioenergy crops. An improved understanding of CAM has potential for high returns on research investment. To exploit the potential of CAM crops and CAM bioengineering, it will be necessary to elucidate the evolution, genomic features, and regulatory mechanisms of CAM. Field trials and predictive models will be required to assess the productivity of CAM crops, while new synthetic biology approaches need to be developed for CAM engineering. Infrastructure will be needed for CAM model systems, field trials, mutant collections, and data management. © 2015 ORNL/UT-Battelle New Phytologist © 2015 New Phytologist Trust.

  14. Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC cohort: study protocol and results of the first 3 years of enrollment

    Jee-Seon Shim

    2017-04-01

    Full Text Available Although the etiologies of cardiovascular disease (CVD are widely understood, the goal of finding a globally effective solution for preventing CVD is unrealistic. Therefore, we aimed to conduct a community-based prospective study on the prevention and management of CVD in Korean adults. This study was designed to recruit 8,000 healthy adults over the course of 5 years. The baseline assessment includes a wide range of established CVD risk factors, including demographic characteristics, medical history, health behaviors, psychological conditions, body size and composition, blood pressure, the augmentation index, carotid ultrasonography, an electrocardiogram, and biochemical indicators, as well as some novel factors, such as social network characteristics, exposure to environmental pollutants, inflammatory markers, hemostatic markers, and immunosenescence markers. Annual telephone interviews and follow-up health examinations at 5-year intervals after the baseline assessment are planned to collect information on changes in health status and its determinants. Additionally, indirect follow-up using secondary data sources will be conducted to obtain information on health services utilization and death. So far, more than 6,000 adults have been enrolled during the first three and a half years, and almost all participants have been tracked by annual telephone follow-up surveys. The data have been uploaded to iCReaT, the clinical research information management system of the Korea National Institute of Health.

  15. 22 CFR 63.6 - Assignment of United States Government employees to consult, lecture, teach, engage in research...

    2010-04-01

    ... Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES PAYMENTS TO AND ON BEHALF OF PARTICIPANTS IN THE INTERNATIONAL EDUCATIONAL AND CULTURAL EXCHANGE PROGRAM § 63.6 Assignment of United States... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Assignment of United States Government...

  16. Determining Your Potential as an Entrepreneur. PACE Revised. Level 3. Unit 2. Research & Development Series No. 240CB2.

    Ashmore, M. Catherine; Pritz, Sandra G.

    This individualized, competency-based unit on determining one's potential as an entrepreneur, the second of 18 modules, is on the third level of the revised Program for Acquiring Competence in Entrepreneurship (PACE). Intended for the advanced secondary and postsecondary levels and for adults wanting training or retraining, this unit, together…

  17. Planning the Marketing Strategy. PACE Revised. Level 3. Unit 6. Research & Development Series No. 240CB6.

    Ashmore, M. Catherine; Pritz, Sandra G.

    This individualized, competency-based unit on planning marketing strategy, the sixth of 18 modules, is on the third level of the revised Program for Acquiring Competence in Entrepreneurship (PACE). Intended for the advanced secondary and postsecondary levels and for adults wanting training or retraining, this unit, together with the other…

  18. Speaking the right language: the scientific method as a framework for a continuous quality improvement program within academic medical research compliance units.

    Nolte, Kurt B; Stewart, Douglas M; O'Hair, Kevin C; Gannon, William L; Briggs, Michael S; Barron, A Marie; Pointer, Judy; Larson, Richard S

    2008-10-01

    The authors developed a novel continuous quality improvement (CQI) process for academic biomedical research compliance administration. A challenge in developing a quality improvement program in a nonbusiness environment is that the terminology and processes are often foreign. Rather than training staff in an existing quality improvement process, the authors opted to develop a novel process based on the scientific method--a paradigm familiar to all team members. The CQI process included our research compliance units. Unit leaders identified problems in compliance administration where a resolution would have a positive impact and which could be resolved or improved with current resources. They then generated testable hypotheses about a change to standard practice expected to improve the problem, and they developed methods and metrics to assess the impact of the change. The CQI process was managed in a "peer review" environment. The program included processes to reduce the incidence of infections in animal colonies, decrease research protocol-approval times, improve compliance and protection of animal and human research subjects, and improve research protocol quality. This novel CQI approach is well suited to the needs and the unique processes of research compliance administration. Using the scientific method as the improvement paradigm fostered acceptance of the project by unit leaders and facilitated the development of specific improvement projects. These quality initiatives will allow us to improve support for investigators while ensuring that compliance standards continue to be met. We believe that our CQI process can readily be used in other academically based offices of research.

  19. Lansoprazole use and tuberculosis incidence in the United Kingdom Clinical Practice Research Datalink: A population based cohort.

    Yates, Tom A; Tomlinson, Laurie A; Bhaskaran, Krishnan; Langan, Sinead; Thomas, Sara; Smeeth, Liam; Douglas, Ian J

    2017-11-01

    Recent in vitro and animal studies have found the proton pump inhibitor (PPI) lansoprazole to be highly active against Mycobacterium tuberculosis. Omeprazole and pantoprazole have no activity. There is no evidence that, in clinical practice, lansoprazole can treat or prevent incident tuberculosis (TB) disease. We studied a cohort of new users of lansoprazole, omeprazole, or pantoprazole from the United Kingdom Clinical Practice Research Datalink to determine whether lansoprazole users have a lower incidence of TB disease than omeprazole or pantoprazole users. Negative control outcomes of myocardial infarction (MI) and herpes zoster were also studied. Multivariable Cox proportional hazards regression was used to adjust for potential confounding by a wide range of factors. We identified 527,364 lansoprazole initiators and 923,500 omeprazole or pantoprazole initiators. Lansoprazole users had a lower rate of TB disease (n = 86; 10.0 cases per 100,000 person years; 95% confidence interval 8.1-12.4) than omeprazole or pantoprazole users (n = 193; 15.3 cases per 100,000 person years; 95% confidence interval 13.3-17.7), with an adjusted hazard ratio (HR) of 0.68 (0.52-0.89). No association was found with MI (adjusted HR 1.04; 95% confidence interval 1.00-1.08) or herpes zoster (adjusted HR 1.03; 95% confidence interval 1.00-1.06). Limitations of this study are that we could not determine whether TB disease was due to reactivation of latent infection or a result of recent transmission, nor could we determine whether lansoprazole would have a beneficial effect if given to people presenting with TB disease. In this study, use of the commonly prescribed and cheaply available PPI lansoprazole was associated with reduced incidence of TB disease. Given the serious problem of drug resistance and the adverse side effect profiles of many TB drugs, further investigation of lansoprazole as a potential antituberculosis agent is warranted.

  20. Value based pricing, research and development, and patient access schemes. Will the United Kingdom get it right or wrong?

    Towse, Adrian

    2010-09-01

    The National Health Service (NHS) should reward innovation it values. This will enable the NHS and the United Kingdom (UK) economy to benefit and impact positively on the Research and Development (R&D) decision making of companies. The National Institute for Health and Clinical Excellence (NICE) currently seeks to do this on behalf of the NHS. Yet the Office of Fair Trading proposals for Value Based Pricing add price setting powers--initially for the Department of Health (DH) and then for NICE. This introduces an additional substantial uncertainty that will impact on R&D and, conditional on R&D proceeding, on launch (or not) in the UK. Instead of adding to uncertainty the institutional arrangements for assessing value should seek to be predictable and science based, building on NICE's current arrangements. The real challenge is to increase understanding of the underlying cost-effectiveness of the technology itself by collecting evidence alongside use. The 2009 Pharmaceutical Price Regulation Scheme sought to help do this with Flexible Pricing (FP) and Patient Access Schemes (PASs). The PASs to date have increased access to medicines, but no schemes proposed to date have yet helped to tackle outcomes uncertainty. The 2010 Innovation Pass can also be seen as a form of 'coverage with evidence development.' The NHS is understandably concerned about the costs of running such evidence collection schemes. Enabling the NHS to deliver on such schemes will impact favourably on R&D decisions. Increasing the uncertainty in the UK NHS market through government price setting will reduce incentives for R&D and for early UK launch.

  1. Report by the AERES on the unit: Research unit on the environment under the supervision of establishments and bodies: IRSN; Rapport de l'AERES sur l'unite: Unite de Recherches en Environnement sous tutelle des etablissements et organismes: IRSN

    NONE

    2010-10-15

    This report is a kind of audit report on a research laboratory. The authors discuss an assessment of the whole unit activities in terms of strengths and opportunities, aspects to be improved and risks, productions and publications, scientific quality, influence and attractiveness (awards, recruitment capacity, capacity to obtain financing and to tender, participation to international programs), strategy and governance, and project. These same aspects are then discussed and commented for each research axis: study of the seismic hazard, study of risk management related to waste storage in deep geological layer, radionuclide transfer in the biosphere, study of the effects on ecosystems of a chronic exposure to radioactive materials

  2. Report by the AERES on the unit: Research Unit on Reactor Safety under the supervision of the establishments and bodies: Radioprotection and Nuclear Safety Institute; Rapport de l'AERES sur l'unite: Unite de Recherche en Surete des Reacteurs sous tutelle des etablissements et organismes: Institut de Radioprotection et de Surete Nucleaire

    NONE

    2010-10-15

    This report is a kind of audit report on a research laboratory whose activity is organized according to the following themes: behaviour of nuclear fuel under accidental conditions, core fusion accidents, fire in confined environment, and civil engineering and structure behaviour. The authors discuss an assessment of the unit activities in terms of strengths and opportunities, aspects to be improved and recommendations, productions and publications. A more detailed assessment is presented in terms of scientific quality, influence and attractiveness (awards, recruitment capacity, capacity to obtain financing and to tender, participation to international programs), strategy and governance, and project. Each research theme is analyzed in the same way

  3. Similar or Different?: A Comparative Analysis of Higher Education Research in Political Science and International Relations between the United States of America and the United Kingdom

    Blair, Alasdair

    2015-01-01

    This article focuses on the nature of the writing in 73 articles published in six U.S. and U.K. political science and international relations journals that focus on teaching and learning. A comparative analysis is made of the articles through a review of the characteristics of the authors, the themes researched, the analytical focus, the research…

  4. Research

    abp

    2016-01-27

    Jan 27, 2016 ... obesity, hypertension and diabetes in urban and rural. Cameroon. International Journal Of Obesity. 2002; 26(7):. 1009-116. PubMed | Google Scholar. 13. Akintunde AA, Ayodele OE, Akinwusi PO, Opadijo GO. Metabolic syndrome: comparison of occurrence using three definitions in hypertensive patients.

  5. Research

    2012-10-30

    Oct 30, 2012 ... Prevalence of lipodystrophy and metabolic syndrome among HIV positive ... Use of highly active antiretroviral therapy has led to significant ..... Hypertriglyceridemia were detected in 39%, hypertension in 35.1%, impaired fasting plasma glucose in 24.9%, low HDL .... resistance due to altered fat distribution.

  6. Research

    abp

    2017-05-15

    May 15, 2017 ... Cardiometabolic risk among HIV-Positive Ugandan adults: prevalence, predictors and effect of ... term HIV infection, lifestyle changes, aging and the toxic effects of. ART, are ... Blood pressure and pulse rate were measured using the Omron M6 ..... guidelines on the prevention and management of metabolic.

  7. Forest products research and development organizations in a worldwide setting: A review of structure, governance, and measures of performance of organizations outside the United States

    Paul V. Ellefson; Michael A. Kilgore; Kenneth E. Skog; Christopher D. Risbrudt

    2007-01-01

    Located in 23 countries, 40 forest-products research and development organizations outside the United States were reviewed in 2004 and 2005. The intent was to obtain a better understanding of how such organizations are structured and administered and their performance judged. Investing over $600 million annually, the 40 organizations employed 7,000 to 7,500 scientists...

  8. Locally Based Research and Development Units as Knowledge Brokers and Change Facilitators in Health and Social Care of Older People in Sweden

    Nyström, Monica Elisabeth; Hansson, Johan; Garvare, Rickard; Andersson-Bäck, Monica

    2015-01-01

    This article investigates the role of locally based research and development units (R&Ds) focusing on health and social services. Nearly 300 local R&Ds are funded by the Swedish government with the intention to facilitate knowledge transfer and development of high quality and effective health and social care organisations. Based on…

  9. The Text of Tile Master Agreement between the Agency and the United States of America Governing Sales of Source, By- Product and Special Nuclear Materials for research Purposes

    1974-01-01

    The text of the Master Agreement Governing Sales of Source, Bye Product and Special Nuclear Materials for Research Purposes, which has been concluded between the Agency and the Government of the United States of America, is reproduced herein for the information of all Members,

  10. The TIMSS Videotape Classroom Study: Methods and Findings from an Exploratory Research Project on Eighth-Grade Mathematics Instruction in Germany, Japan, and the United States.

    Stigler, James W.; Gonzales, Patrick; Kawanaka, Takako; Knoll, Steffen; Serrano, Ana

    1999-01-01

    Describes the methods and preliminary findings of the Videotape Classroom Study, a video survey of eighth-grade mathematics lessons in Germany, Japan, and the United States. Part of the Third International Mathematics and Science study, this research project is the first study of videotaped records from national probability samples. (SLD)

  11. Incidence of hypochloremic metabolic alkalosis in dogs and cats with and without nasogastric tubes over a period of up to 36 hours in the intensive care unit.

    Chih, Annie; Rudloff, Elke; Waldner, Cheryl; Linklater, Andrew K J

    2018-05-01

    To evaluate the incidence of hypochloremic metabolic alkalosis (HCMA) in dogs and cats in the ICU that had intermittent nasogastric tube (NGT) aspiration for up to 36 hours. Prospective cohort study (December 2013 to October 2014). Privately owned emergency and referral teaching hospital. Forty-nine client-owned dogs and 16 client-owned cats. Patients wherein NGT placement was recommended and client consent was obtained were included in the interventional group. Those with an NGT placed (NGT group) had the NGT aspirated every 4 hours. Patients for whom placement of a NGT was declined by the owner served as a reference group (NoNGT). Venous blood gas and electrolyte values were obtained every 12 hours. Thirty-five dogs and cats had an NGT placed. Thirty dogs and cats did not have an NGT placed. The serum venous blood gas and electrolyte changes were compared over time within the NGT group and between the NGT and NoNGT groups. No cases developed HCMA. In the NGT group, blood pH increased over time. There was no significant difference between the NGT and the NoNGT group in the average value of pH, HCO 3 - , base excess, chloride, or corrected chloride. Serum venous blood gas, chloride, and corrected chloride changes were not associated with the volumes of gastric fluid aspirated over time. In this small population of dogs and cats, intermittent NGT aspiration was not associated with the development of HCMA over a period of up to 36 hours after NGT placement. © Veterinary Emergency and Critical Care Society 2018.

  12. Analysis of VSAM Research at Carnegie Mellon University and the Sarnoff Corporation: Potential Application to Small Unit Operations

    Dion-Schwarz, Cynthia

    1999-01-01

    This paper summarizes an analysis of the Video Surveillance and Monitoring (VSAM) research being conducted by researchers at Carnegie Mellon University and the Sarnoff Corporation under the Defense Advanced Research Projects Agency...

  13. The National Shipbuilding Research Program, 1997 Ship Production Symposium, Paper No. 21: A Parametric Approach to Machinery Unitization in Shipbuilding

    Jaquith, Peter E; Burns, Richard M; Duneclift, Lee A; Gaskari, Massood; Green, Thomas; Silveira, John L; Walsh, Anthony

    1997-01-01

    During the past ten years, both U.S. and foreign shipyards have developed advanced unitization concepts that include multi-level assemblies representing large vertical segments of ship machinery spaces...

  14. Ca-48 metabolism studies

    Van der Merwe, D.G.

    1987-03-01

    Calcium metabolism has been studied in depth physiologically and is a relatively well-understood element in biochemistry and medicine. There is still only restricted knowledge of the metabolic fate of calcium in normal and abnormal paediatric subjects. The latter is partially owing to inadequate techniques for tracing and modelling calcium pathways in children. The advent of radioactive tracers has unquestionably enhanced medical research and improved the quality of many metabolic studies. The present study was aimed at the development, promotion and justification of a new tracer technique using the stable isotope, calcium-48. The obvious advantages of such a technique are its harmlessness tothe subject, its applicability to both short- and long-term studies as well as its usefulness to the study for which it was originally motivated, viz research defining the actual relationship between a calcium-deficient diet and the occurrence of rickets in rural Black children in South Africa. Exploratory instrumental analyses were performed specifically with serum samples. This proved successful enough to develop a less specific pre-concentration technique which improved the sensitivity and reduces the cost of doing calcium-48 metabolism studies. The results of a simple metabolic study are presented whereby the scope of the technique is demonstrated in a real situation. The possibilities and limitations of double-isotope metabolic studies are discussed, particularly with regard to strontium as the second tracer

  15. Enculturation, perceived stress, and physical activity: implications for metabolic risk among the Yup'ik--the Center for Alaska Native Health Research Study.

    Bersamin, Andrea; Wolsko, Christopher; Luick, Bret R; Boyer, Bert B; Lardon, Cecile; Hopkins, Scarlett E; Stern, Judith S; Zidenberg-Cherr, Sheri

    2014-06-01

    American Indians and Alaska Natives (ANs) report among the lowest levels of physical activity in the USA, but there is very little systematic research examining the determinants of physical activity patterns in these populations. This study investigated the relationships between enculturation (or cultural traditionality), psychosocial stress, and physical activity in a community-based sample of Yup'ik women and men living in rural AN communities. Associations between these variables and several metabolic risk factors were also examined. A sample of 488 Yup'ik participants (284 women and 204 men) from six villages in the Yukon-Kuskokwim Delta region completed a wellness survey and an array of physiological assessments [e.g., body mass index (BMI), blood pressure]. A subset of 179 participants also completed a 3-day pedometer assessment of physical activity. Multivariate linear regression models indicated that participants who were more enculturated (i.e., living more of a traditional lifestyle) and who experienced lower levels of psychosocial stress were significantly more physically active. In turn, both lower levels of psychosocial stress and higher levels of physical activity were associated with lower BMI, lower percent body fat, and lower waist circumference. Findings underscore the importance of gaining a culturally specific understanding of physical activity patterns in indigenous groups in order to inform effective health promotion strategies.

  16. Epigenetics and Cellular Metabolism

    Wenyi Xu

    2016-01-01

    Full Text Available Living eukaryotic systems evolve delicate cellular mechanisms for responding to various environmental signals. Among them, epigenetic machinery (DNA methylation, histone modifications, microRNAs, etc. is the hub in transducing external stimuli into transcriptional response. Emerging evidence reveals the concept that epigenetic signatures are essential for the proper maintenance of cellular metabolism. On the other hand, the metabolite, a main environmental input, can also influence the processing of epigenetic memory. Here, we summarize the recent research progress in the epigenetic regulation of cellular metabolism and discuss how the dysfunction of epigenetic machineries influences the development of metabolic disorders such as diabetes and obesity; then, we focus on discussing the notion that manipulating metabolites, the fuel of cell metabolism, can function as a strategy for interfering epigenetic machinery and its related disease progression as well.

  17. Harmonizing the definition of the metabolic syndrome: comparison of the criteria of the Adult Treatment Panel III and the International Diabetes Federation in United States American and European populations.

    Assmann, Gerd; Guerra, Rudy; Fox, Garrett; Cullen, Paul; Schulte, Helmut; Willett, DuWayne; Grundy, Scott M

    2007-02-15

    The 2 most widely used criteria to diagnose the metabolic syndrome (MS) are those developed by the United States Adult Treatment Panel III of the National Cholesterol Education Program (ATP III) and by the International Diabetes Federation (IDF). A major difference between these 2 sets of criteria is that the IDF places more emphasis on waist circumference. We compared the prevalence of MS using the ATP III and the IDF guidelines in 2 American (the Dallas Health Study and National Health and Nutrition Examination Survey) and 1 German (Prospective Cardiovascular Munster study) population samples. When the ATP III criteria were used, the prevalence of MS was higher in the United States than the German samples in both women (37% vs. 18%) and men (30% vs 25%), whereas when the IDF criteria were used, the prevalence of MS was 25% higher in the German than the American sample. Although in the United States both sets of criteria identified mostly the same people (concordance of about 90%), this was less true in Germany (concordance about 80%). To determine which criteria better predicted adverse cardiovascular outcomes, the incidence of coronary events associated with MS, as defined using the ATP III or the IDF criteria, were compared over a 10-year period among the middle-aged men in the German sample (n = 7,152). A total of 3.4% of men without MS developed an event. A much higher percentage of the men with MS defined by the ATP III criteria (10.7%) than the IDF criteria (5.5%) had a cardiovascular event. In conclusion, although the prevalence of MS was higher when the IDF criteria were used in the German sample, the IDF criteria have lower predictive power for coronary events.

  18. Reduced Cortisol Metabolism during Critical Illness

    Boonen, Eva; Vervenne, Hilke; Meersseman, Philippe; Andrew, Ruth; Mortier, Leen; Declercq, Peter E.; Vanwijngaerden, Yoo-Mee; Spriet, Isabel; Wouters, Pieter J.; Perre, Sarah Vander; Langouche, Lies; Vanhorebeek, Ilse; Walker, Brian R.; Van den Berghe, Greet

    2015-01-01

    BACKGROUND Critical illness is often accompanied by hypercortisolemia, which has been attributed to stress-induced activation of the hypothalamic–pituitary–adrenal axis. However, low corticotropin levels have also been reported in critically ill patients, which may be due to reduced cortisol metabolism. METHODS In a total of 158 patients in the intensive care unit and 64 matched controls, we tested five aspects of cortisol metabolism: daily levels of corticotropin and cortisol; plasma cortisol clearance, metabolism, and production during infusion of deuterium-labeled steroid hormones as tracers; plasma clearance of 100 mg of hydrocortisone; levels of urinary cortisol metabolites; and levels of messenger RNA and protein in liver and adipose tissue, to assess major cortisol-metabolizing enzymes. RESULTS Total and free circulating cortisol levels were consistently higher in the patients than in controls, whereas corticotropin levels were lower (PCortisol production was 83% higher in the patients (P=0.02). There was a reduction of more than 50% in cortisol clearance during tracer infusion and after the administration of 100 mg of hydrocortisone in the patients (P≤0.03 for both comparisons). All these factors accounted for an increase by a factor of 3.5 in plasma cortisol levels in the patients, as compared with controls (Pcortisol clearance also correlated with a lower cortisol response to corticotropin stimulation. Reduced cortisol metabolism was associated with reduced inactivation of cortisol in the liver and kidney, as suggested by urinary steroid ratios, tracer kinetics, and assessment of liver-biopsy samples (P≤0.004 for all comparisons). CONCLUSIONS During critical illness, reduced cortisol breakdown, related to suppressed expression and activity of cortisol-metabolizing enzymes, contributed to hypercortisolemia and hence corticotropin suppression. The diagnostic and therapeutic implications for critically ill patients are unknown. (Funded by the Belgian

  19. Validation of Surgical Intensive Care-Infection Registry: a medical informatics system for intensive care unit research, quality of care improvement, and daily patient care.

    Golob, Joseph F; Fadlalla, Adam M A; Kan, Justin A; Patel, Nilam P; Yowler, Charles J; Claridge, Jeffrey A

    2008-08-01

    We developed a prototype electronic clinical information system called the Surgical Intensive Care-Infection Registry (SIC-IR) to prospectively study infectious complications and monitor quality of care improvement programs in the surgical and trauma intensive care unit. The objective of this study was to validate SIC-IR as a successful health information technology with an accurate clinical data repository. Using the DeLone and McLean Model of Information Systems Success as a framework, we evaluated SIC-IR in a 3-month prospective crossover study of physician use in one of our two surgical and trauma intensive care units (SIC-IR unit versus non SIC-IR unit). Three simultaneous research methodologies were used: a user survey study, a pair of time-motion studies, and an accuracy study of SIC-IR's clinical data repository. The SIC-IR user survey results were positive for system reliability, graphic user interface, efficiency, and overall benefit to patient care. There was a significant decrease in prerounding time of nearly 4 minutes per patient on the SIC-IR unit compared with the non SIC-IR unit. The SIC-IR documentation and data archiving was accurate 74% to 100% of the time depending on the data entry method used. This accuracy was significantly improved compared with normal hand-written documentation on the non SIC-IR unit. SIC-IR proved to be a useful application both at individual user and organizational levels and will serve as an accurate tool to conduct prospective research and monitor quality of care improvement programs.

  20. [Metabolic acidosis].

    Regolisti, Giuseppe; Fani, Filippo; Antoniotti, Riccardo; Castellano, Giuseppe; Cremaschi, Elena; Greco, Paolo; Parenti, Elisabetta; Morabito, Santo; Sabatino, Alice; Fiaccadori, Enrico

    2016-01-01

    Metabolic acidosis is frequently observed in clinical practice, especially among critically ill patients and/or in the course of renal failure. Complex mechanisms are involved, in most cases identifiable by medical history, pathophysiology-based diagnostic reasoning and measure of some key acid-base parameters that are easily available or calculable. On this basis the bedside differential diagnosis of metabolic acidosis should be started from the identification of the two main subtypes of metabolic acidosis: the high anion gap metabolic acidosis and the normal anion gap (or hyperchloremic) metabolic acidosis. Metabolic acidosis, especially in its acute forms with elevated anion gap such as is the case of lactic acidosis, diabetic and acute intoxications, may significantly affect metabolic body homeostasis and patients hemodynamic status, setting the stage for true medical emergencies. The therapeutic approach should be first aimed at early correction of concurrent clinical problems (e.g. fluids and hemodynamic optimization in case of shock, mechanical ventilation in case of concomitant respiratory failure, hemodialysis for acute intoxications etc.), in parallel to the formulation of a diagnosis. In case of severe acidosis, the administration of alkalizing agents should be carefully evaluated, taking into account the risk of side effects, as well as the potential need of renal replacement therapy.

  1. Hematopoietic Stem Cell Transplantation Activity in Pediatric Cancer between 2008 and 2014 in the United States: A Center for International Blood and Marrow Transplant Research Report.

    Khandelwal, Pooja; Millard, Heather R; Thiel, Elizabeth; Abdel-Azim, Hisham; Abraham, Allistair A; Auletta, Jeffery J; Boulad, Farid; Brown, Valerie I; Camitta, Bruce M; Chan, Ka Wah; Chaudhury, Sonali; Cowan, Morton J; Angel-Diaz, Miguel; Gadalla, Shahinaz M; Gale, Robert Peter; Hale, Gregory; Kasow, Kimberly A; Keating, Amy K; Kitko, Carrie L; MacMillan, Margaret L; Olsson, Richard F; Page, Kristin M; Seber, Adriana; Smith, Angela R; Warwick, Anne B; Wirk, Baldeep; Mehta, Parinda A

    2017-08-01

    This Center for International Blood and Marrow Transplant Research report describes the use of hematopoietic stem cell transplantation (HSCT) in pediatric patients with cancer, 4408 undergoing allogeneic (allo) and3076 undergoing autologous (auto) HSCT in the United States between 2008 and 2014. In both settings, there was a greater proportion of boys (n = 4327; 57%), children reports of transplant practices in the United States. Copyright © 2017 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

  2. The TIMSS Videotape Classroom Study: Methods and Findings from an Exploratory Research Project on Eighth-Grade Mathematics Instruction in Germany, Japan, and the United States. A Research and Development Report.

    Stigler, James W.; Gonzales, Patrick; Kwanaka, Takako; Knoll, Steffen; Serrano, Ana

    This report presents the methods and preliminary findings of the Videotape Classroom Study, a video study of eighth-grade mathematics lessons in Germany, Japan, and the United States. This exploratory research project is part of the Third International Mathematics and Science Study (TIMSS). The study included 231 eighth-grade mathematics…

  3. Research

    In pharmacy education, the development of a professional identity has remained .... component completed at the Interdisciplinary Teaching and Learning Unit at UWC. .... did not know that becoming a pharmacist was all about care taking and.

  4. Research

    abp

    2014-05-10

    May 10, 2014 ... Key words: Computerized Tomographic Scan, chronic rhinosinusitis, nasal discharge, nasal .... evaluated using bone window (window width 2,000 Hounsfield units ..... paranasal sinuses and chronic sinusitis in children.

  5. Cerebral Metabolism and the Role of Glucose Control in Acute Traumatic Brain Injury.

    Buitrago Blanco, Manuel M; Prashant, Giyarpuram N; Vespa, Paul M

    2016-10-01

    This article reviews key concepts of cerebral glucose metabolism, neurologic outcomes in clinical trials, the biology of the neurovascular unit and its involvement in secondary brain injury after traumatic brain insults, and current scientific and clinical data that demonstrate a better understanding of the biology of metabolic dysfunction in the brain, a concept now known as cerebral metabolic energy crisis. The use of neuromonitoring techniques to better understand the pathophysiology of the metabolic crisis is reviewed and a model that summarizes the triphasic view of cerebral metabolic disturbance supported by existing scientific data is outlined. The evidence is summarized and a template for future research provided. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. Association of Vitamin D receptor gene polymorphisms with metabolic syndrome and its components among adult Arabs from the United Arab Emirates.

    Hasan, Hayder A; AbuOdeh, Ra'ed O; Muda, Wan Abdul Manan Bin Wan; Mohamed, Hamid Jan Bin Jan; Samsudin, Ab Rani

    2017-12-01

    The aim was to investigate relationships of Vitamin D receptor gene (VDR) polymorphisms to the components of MetS among Arabs adult residing in the United Arab Emirates. A cross-sectional study of 198 Arabs adult (50 males and 148 females). Serum levels of glucose, vitamin D, HDL-C, and TG, and blood pressure were measured. FokI, BsmI & TaqI genotyping of VDR were investigated using PCR-RFLP technique. Age of the participants was 21(9) years with a BMI of 26.8(7.8) kg/m 2 . About 15% had MetS with serum vitamin D levels of 25.5(18.2) nmol/L. VDR genotyping yielded: FokI: 57.1% FF and 38.9% Ff, BsmI: 29.8% bb and 51.5% Bb, while TaqI showed 39.4% TT and 43.4% Tt. The ff carriers had higher total cholesterol [174(12.4) mg/dl] than FF and Ff genotypes. Bb carriers showed higher BMI and LDL-C than BB and bb genotypes. In females, FokI VDR polymorphism showed significant association with systolic blood pressure (SBP) and F allele carriers were at higher risk of developing high SBP [x 2 =4.4, df1, OR=0.29 (95%CI: 0.087-0.98), p=0.035]. VDR gene polymorphisms were not associated with MetS, yet it may affect the severity of some of components of MetS, namely the association of BsmI with obesity, FokI and BsmI with dyslipidemia and FokI with SBP. Copyright © 2017 Diabetes India. Published by Elsevier Ltd. All rights reserved.

  7. Particle Physics and Astronomy Research Council (PPARC) members, United Kingdom, visiting the ATLAS semiconductor tracker (SCT) module tests.

    Patrice Loïez

    2002-01-01

    Photo 01: Mr Peter Warry, PPARC Chairman, Victrex Plc, United Kingdom visiting the ATLAS SCT module tests with Dr Joleen Pater, SCT (Manchester). Photo 02: PPARC Council Members, United Kingdom, visiting the ATLAS SCT module tests. L.t to r.: Mrs Judith Scott, Chief Executive, British Computer Society, Prof. George Efstathiou, Institute of Astronomy, University of Cambridge, Mr Peter Warry, PPARC Chairman, Victrex Plc, Prof. Martin Ward, Director X-Ray Astronomy, of Leicester, Prof. James Stirling, Director, Institute for Particle Physics Phenomenology, University of Durham and Prof. Brian Foster, University of Bristol.

  8. Drug Metabolism

    Home; Journals; Resonance – Journal of Science Education; Volume 19; Issue 3. Drug Metabolism: A Fascinating Link Between Chemistry and Biology. Nikhil Taxak Prasad V Bharatam. General Article Volume 19 Issue 3 March 2014 pp 259-282 ...

  9. Drug Metabolism

    IAS Admin

    behind metabolic reactions, importance, and consequences with several ... required for drug action. ... lism, which is catalyzed by enzymes present in the above-men- ... catalyze the transfer of one atom of oxygen to a substrate produc-.

  10. A bibliometric review of drug and alcohol research focused on Indigenous peoples of Australia, New Zealand, Canada and the United States.

    Clifford, Anton; Shakeshaft, Anthony

    2017-07-01

    Indigenous peoples of Australia, New Zealand, Canada and the United States experience a disproportionately high burden of harms from substance misuse. Research is therefore required to improve our understanding of substance use in Indigenous populations and provide evidence on strategies effective for reducing harmful use. A search of 13 electronic databases for peer-reviewed articles published between 1993 and 2014 focusing on substance use and Indigenous peoples of Australia, New Zealand, Canada and the United States. Relevant abstracts were classified as data or non-data based research. Data-based studies were further classified as measurement, descriptive or intervention and their trends examined by country and drug type. Intervention studies were classified by type and their evaluation designs classified using the Cochrane Effective Practice and Organisation of Care (EPOC) data collection checklist. There was a statistically significant increase from 1993 to 2014 in the percentage of total publications that were data-based (P Indigenous drug and alcohol field are required. The dominance of descriptive research in the Indigenous drug and alcohol field is less than optimal for generating evidence to inform Indigenous drug and alcohol policy and programs. [Clifford A, Shakeshaft A. A bibliometric review of drug and alcohol research focused on Indigenous peoples of Australia, New Zealand, Canada and the United States. Drug Alcohol Rev 2017;36:509-522]. © 2017 Australasian Professional Society on Alcohol and other Drugs.

  11. Health Services Research Spending and Healthcare System Impact; Comment on “Public Spending on Health Service and Policy Research in Canada, the United Kingdom, and the United States: A Modest Proposal”

    Morris L. Barer

    2018-03-01

    Full Text Available The challenges associated with translating health services and policy research (HSPR evidence into practice are many and long-standing. Indeed, those challenges have themselves spawned new areas of research, including knowledge translation and implementation science. These sub-disciplines have increased our understanding of the critical success factors associated with the uptake of research evidence into (system practice. Engaging those for whom research evidence is likely to help solve implementation and/or policy problems, and ensuring that they are key partners throughout the research life-cycle, appear to us (based on current evidence to be the most direct and effective paths to improved knowledge translation. In that regard, building on Canada’s recent Strategy for Patient Oriented Research (SPOR would seem to offer considerable promise. The “modest” proposals offered by Thakkar and Sullivan seem less likely to bear fruit.

  12. United States Air Force Personalized Medicine and Advanced Diagnostics Program Panel: Representative Research at the San Antonio Military Medical Center

    2016-05-20

    health system. dedicated to excellence in global care PROCESSING OF PROFESSIONAL MEDICAL RESEARCH PUBLICATIONS/PRESENTATIONS INSTRUCTIONS 1. The...present this research at the University of Texas at San Antonio/SAMHS & Universities Research Forum, SURF 2016 in San Antonio, TX, on 20 May 2016. The...at San Antonio/SAMHS & Universities Research Forum, SURF 2016 in San Antonio, TX, on 20 May 2016. 3. LAWS AND REGULATIONS: DoD 5500.07-R, Joint

  13. Development of Unique Advanced Medical Research and Development Initiatives in the Western United States and Pacific Rim

    2012-11-01

    funding). Funding from the TATRC/Qualcomm innovation challenge allowed the vLC to expand its TAP (Technology Acceleration Program) model to the...innovative research challenges and pilot projects. Relevance: This research effort to build partnerships and collaborations has significant benefit to...the proposal was Specific research under task 2 of this award has been the following: 1) “Grand Challenge ” in Military Medicine Research, 2) Packaging

  14. Research

    ebutamanya

    2015-03-02

    Mar 2, 2015 ... Joseph Daniels1,&, Ruth Nduati1,2, James Kiarie1,3, Carey Farquhar1,4,5 .... or basic science research career (Socio-Behavioral Research, .... a research environment that supports knowledge sharing to develop research ...

  15. 77 FR 40529 - Soybean Promotion and Research: Amend the Order To Adjust Representation on the United Soybean Board

    2012-07-10

    ... Service 7 CFR Part 1220 [Doc. No. AMS-LS-12-0022] Soybean Promotion and Research: Amend the Order To... in 2009. As required by the Soybean Promotion, Research, and Consumer Information Act (Act... members from 69 to 70. These changes would be reflected in the Soybean Promotion and Research Order (Order...

  16. Being a Mobile International Postgraduate Research Student with Family in the United Kingdom: Conflict, Contestation and Contradictions

    Mwale, Shadreck; Alhawsawi, Sajjadllah; Sayed, Yusuf; Rind, Irfan. A.

    2018-01-01

    The internationalisation of higher education has influenced the dramatic rise in the mobility of students, academics and knowledge across borders. There has been growing research interest focusing on international students studying abroad. While the student experience is an area of education that is often researched, most research focuses on…

  17. Organisation of biological research carried out in the United States by the A.E.C. or under her contract (1960)

    Pellerin, J.

    1960-01-01

    This report is based on information gathered in the course of a trip to the United States, in November and December 1958 which consisted chiefly of visits to the main biological and medical research laboratories and discussions with the heads of these establishments. A description is given of the general organisation of the Atomic Energy Commission's Division of Biology and Medicine, and of the distribution of responsibility for radiation protection work and for biological, medical and agricultural research amongst the various Services attached to it; this is followed by a more detailed account of the activities carried on in this field at the great national laboratories. Finally, the systems of collaboration set up with external research organisations in the form of research contracts are examined, together with the substantial help provided by the A.E.C. for biological, medical and agricultural research in general, owing to a systematic policy of subsidising the distribution of radioisotopes for this purpose. (author) [fr

  18. Metabolic Myopathies.

    Tarnopolsky, Mark A

    2016-12-01

    Metabolic myopathies are genetic disorders that impair intermediary metabolism in skeletal muscle. Impairments in glycolysis/glycogenolysis (glycogen-storage disease), fatty acid transport and oxidation (fatty acid oxidation defects), and the mitochondrial respiratory chain (mitochondrial myopathies) represent the majority of known defects. The purpose of this review is to develop a diagnostic and treatment algorithm for the metabolic myopathies. The metabolic myopathies can present in the neonatal and infant period as part of more systemic involvement with hypotonia, hypoglycemia, and encephalopathy; however, most cases present in childhood or in adulthood with exercise intolerance (often with rhabdomyolysis) and weakness. The glycogen-storage diseases present during brief bouts of high-intensity exercise, whereas fatty acid oxidation defects and mitochondrial myopathies present during a long-duration/low-intensity endurance-type activity or during fasting or another metabolically stressful event (eg, surgery, fever). The clinical examination is often normal between acute events, and evaluation involves exercise testing, blood testing (creatine kinase, acylcarnitine profile, lactate, amino acids), urine organic acids (ketones, dicarboxylic acids, 3-methylglutaconic acid), muscle biopsy (histology, ultrastructure, enzyme testing), MRI/spectroscopy, and targeted or untargeted genetic testing. Accurate and early identification of metabolic myopathies can lead to therapeutic interventions with lifestyle and nutritional modification, cofactor treatment, and rapid treatment of rhabdomyolysis.

  19. Animal metabolism

    Walburg, H.E.

    1977-01-01

    Studies on placental transport included the following: clearance of tritiated water as a baseline measurement for transport of materials across perfused placentas; transport of organic and inorganic mercury across the perfused placenta of the guinea pig in late gestation; and transport of cadmium across the perfused placenta of the guinea pig in late gestation. Studies on cadmium absorption and metabolism included the following: intestinal absorption and retention of cadmium in neonatal rats; uptake and distribution of an oral dose of cadmium in postweanling male and female, iron-deficient and normal rats; postnatal viability and growth in rat pups after oral cadmium administration during gestation; and the effect of calcium and phosphorus on the absorption and toxicity of cadmium. Studies on gastrointestinal absorption and mineral metabolism included: uptake and distribution of orally administered plutonium complex compounds in male mice; gastrointestinal absorption of 144 Ce in the newborn mouse, rat, and pig; and gastrointestinal absorption of 95 Nb by rats of different ages. Studies on iodine metabolism included the following: influence of thyroid status and thiocyanate on iodine metabolism in the bovine; effects of simulated fallout radiation on iodine metabolism in dairy cattle; and effects of feeding iodine binding agents on iodine metabolism in the calf

  20. 22 CFR 63.7 - Grants to United States participants to consult, lecture, teach, engage in research, demonstrate...

    2010-04-01

    ... Section 63.7 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES PAYMENTS TO AND ON BEHALF OF PARTICIPANTS IN THE INTERNATIONAL EDUCATIONAL AND CULTURAL EXCHANGE PROGRAM § 63.7 Grants to... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Grants to United States participants to consult...

  1. Determining Your Potential as an Entrepreneur. PACE Revised. Level 2. Unit 2. Research & Development Series No. 240BB2.

    Ashmore, M. Catherine; Pritz, Sandra G.

    This unit on determining one's potential as an entrepreneur, the second in a series of 18 modules, is on the second level of the revised PACE (Program for Acquiring Competence in Entrepreneurship) comprehensive curriculum. Geared to advanced secondary and beginning postsecondary or adult students, the modules provide an opportunity to learn about…

  2. "Social, technological, and research responses to potential erosion and sediment disasters in the western United States, with examples from California"

    R. M. Rice

    1985-01-01

    Synopsis - Examples from California are used to illustrate typical responses to erosion and debris flow disasters the United States. Political institutions leave virtually all responsibility for disaster prevention to the lowest levels of government or to individuals. Three circumstances in which disasters occur are discussed: urbanized debris cones, urbanized unstable...

  3. Researched solutions for long-term accommodation units for drug-resistant tuberculosis patients in South Africa

    Parsons, S

    2010-09-01

    Full Text Available H and provincial recipients for the planning, design and construction of the units as well as to manage project implementation. The project has provided a unique opportunity to review current policy, to develop guidelines for long-term accommodation of patients...

  4. Social, technological, and research responses to potential erosion and sediment disasters in the western United States, with examples from California

    R. M. Rice

    1985-01-01

    Examples from California are used to illustrate typical responses to erosion and debris flow disasters in the United States. Political institutions leave virtually all responsibility for disaster prevention to the lowest levels of government or to individuals. Three circumstances in which disasters occur are discussed: urbanized debris cones, urbanized unstable...

  5. AN APPRAISAL OF INSTRUCTIONAL UNITS TO ENHANCE STUDENT UNDERSTANDING OF PROFIT-MAXIMIZING PRINCIPLES. RESEARCH SERIES IN AGRICULTURAL EDUCATION.

    BARKER, RICHARD L.; BENDER, RALPH E.

    TWENTY-TWO SELECTED OHIO VOCATIONAL AGRICULTURE TEACHERS AND 262 JUNIOR AND SENIOR VOCATIONAL AGRICULTURE STUDENTS PARTICIPATED IN A STUDY TO MEASURE THE RELATIVE EFFECTIVENESS OF NEWLY DEVELOPED INSTRUCTIONAL UNITS DESIGNED TO ENHANCE STUDENT UNDERSTANDING OF PROFIT-MAXIMIZING PRINCIPLES IN FARM MANAGEMENT. FARM MANAGEMENT WAS TAUGHT IN THE…

  6. Planning the Marketing Strategy. PACE Revised. Level 1. Unit 6. Research & Development Series No. 240AB6.

    Ashmore, M. Catherine; Pritz, Sandra G.

    This lesson on planning a marketing strategy, the sixth in a series of 18 units, is part of the first level of a comprehensive entrepreneurship curriculum entitled: A Program for Acquiring Competence in Entrepreneurship (PACE). (Designed for use with secondary students, the first level of PACE introduces students to the concepts involved in…

  7. Planning the Marketing Strategy. PACE Revised. Level 2. Unit 6. Research & Development Series No. 240BB6.

    Ashmore, M. Catherine; Pritz, Sandra G.

    This unit on planning marketing strategy for a small business, the sixth in a series of 18 modules, is on the second level of the revised PACE (Program for Acquiring Competence in Entrepreneurship) comprehensive curriculum. Geared to advanced secondary and beginning postsecondary or adult students, the modules provide an opportunity to learn about…

  8. A unified metabolism for Mars: A new approach developed from research on extraterrestrial life detection by enzymatically induced exchange of O 18

    1972-01-01

    A general graded life detection approach ranging from environmental and in situ observations to specific metabolic experiments on Mars is reported. A zero dead volume leak and computer mediated data acquisition system is also discussed. Soil analyses were also conducted.

  9. 'Well, It's the Risk of the Unknown… Right?': A Qualitative Study of Perceived Risks and Benefits of HIV Cure Research in the United States.

    Dubé, Karine; Taylor, Jeff; Sylla, Laurie; Evans, David; Dee, Lynda; Burton, Alasdair; Willenberg, Loreen; Rennie, Stuart; Skinner, Asheley; Tucker, Joseph D; Weiner, Bryan J; Greene, Sandra B

    2017-01-01

    Biomedical research towards an HIV cure is advancing in the United States and elsewhere, yet little is known about perceptions of risks and benefits among potential study participants and other stakeholders. We conducted a qualitative study to explore perceived risks and benefits of investigational HIV cure research among people living with HIV (PLWHIV), biomedical HIV cure researchers, policy-makers and bioethicists. We conducted a qualitative research study using in-depth interviews with a purposive sample of PLWHIV, biomedical HIV cure researchers, policy-makers and bioethicists in 2015-2016. We analysed interview transcripts using thematic analysis anchored in grounded theory. We conducted and analyzed 36 key informant interviews. Qualitative analysis revealed four main findings. 1) Potential HIV cure study volunteers noted needing more information and education about the potential risks of HIV cure research. 2) Biomedical HIV cure researchers, policy-makers and bioethicists showed less awareness of social and financial risks of HIV cure research than PLWHIV. 3) Most respondents across the different categories of informants identified some risks that were too great to be acceptable in HIV cure research, although a subset of PLWHIV did not place an upper limit on acceptable risk. 4) PLWHIV showed a better awareness of potential psychological benefits of participating in HIV cure research than other groups of stakeholders. Our research suggests that PLWHIV have a variable understanding of the individual risks, sometimes substantial, associated with participating in biomedical HIV cure research studies. Community engagement and increased research literacy may help improve community understanding. Intensive informed consent procedures will be necessary for ethical study implementation. The current state of HIV cure research offers greater potential benefits to society than to participants. There is likely to be disagreement among regulators, researchers, clinicians

  10. 'Well, It's the Risk of the Unknown… Right?': A Qualitative Study of Perceived Risks and Benefits of HIV Cure Research in the United States.

    Karine Dubé

    Full Text Available Biomedical research towards an HIV cure is advancing in the United States and elsewhere, yet little is known about perceptions of risks and benefits among potential study participants and other stakeholders. We conducted a qualitative study to explore perceived risks and benefits of investigational HIV cure research among people living with HIV (PLWHIV, biomedical HIV cure researchers, policy-makers and bioethicists.We conducted a qualitative research study using in-depth interviews with a purposive sample of PLWHIV, biomedical HIV cure researchers, policy-makers and bioethicists in 2015-2016. We analysed interview transcripts using thematic analysis anchored in grounded theory.We conducted and analyzed 36 key informant interviews. Qualitative analysis revealed four main findings. 1 Potential HIV cure study volunteers noted needing more information and education about the potential risks of HIV cure research. 2 Biomedical HIV cure researchers, policy-makers and bioethicists showed less awareness of social and financial risks of HIV cure research than PLWHIV. 3 Most respondents across the different categories of informants identified some risks that were too great to be acceptable in HIV cure research, although a subset of PLWHIV did not place an upper limit on acceptable risk. 4 PLWHIV showed a better awareness of potential psychological benefits of participating in HIV cure research than other groups of stakeholders.Our research suggests that PLWHIV have a variable understanding of the individual risks, sometimes substantial, associated with participating in biomedical HIV cure research studies. Community engagement and increased research literacy may help improve community understanding. Intensive informed consent procedures will be necessary for ethical study implementation. The current state of HIV cure research offers greater potential benefits to society than to participants. There is likely to be disagreement among regulators, researchers

  11. The use of Global Positioning System units and ArcGIS Online to engage K-12 Students in Research Being Done in their Local Communities

    Butcher, C. E.; Sparrow, E. B.; Clucas, T.

    2015-12-01

    Incorporating K-12 students in scientific research processes and opportunities in their communities is a great way to bridge the gap between research and education and to start building science research capacity at an early age. One goal of the Experimental Program to Stimulate Competitive Research (EPSCoR) Alaska Adapting to Changing Environments project is to engage the local community in the research as well as to share results with the people. By giving K-12 students Global Positioning System (GPS) units, and allowing them to collect and map their own data, they are being exposed to some of the research methods being used by scientists in the Alaska ACE project. This hands-on, minds-on method has been successfully used in formal education settings such as a Junior High School classroom in Nuiqsut, Alaska as well as in informal education settings such as summer camps in Barrow, Alaska and Kenai, Alaska. The students progress from mapping by hand to collecting location data with their GPS units and cameras, and imputing this information into ArcGIS Online to create map products. The data collected were from sites ranging from important places in the community to sites visited during summer camps, with students reflecting on data and site significance. Collecting data, using technology, and creating map products contribute to science skills and practices students need to conduct research of their own and to understand research being done around them. The goal of this education outreach implementation is to bring students closer to the research, understand the process of science, and have the students continue to collect data and contribute to research in their communities. Support provided for this work from the Alaska EPSCoR NSF Award #OIA-1208927 and the state of Alaska is gratefully acknowledged.

  12. [Development and basics of metabolic monitoring in dairy cows. Focus on research in Eastern Germany and at the University of Leipzig, Germany].

    Fürll, M

    2016-01-01

    Systematic metabolic monitoring began in German-speaking countries in the late 1960s, early 1970s, due to an increase in metabolic disorders as a cause of infertility and mastitis and aimed at their prevention through early diagnosis. Development of a unified monitoring standard: Initiated by Rossow, Gürtler, Ehrentraut, Seidel and Furcht a standard "metabolic monitoring in cattle production" was developed in the 1970s. It included farm analysis, clinical and biochemical controls, prophylaxis and follow-up controls. Key points were: periodic screenings of heavily loaded, healthy indicator animals 2-4 days post partum (p.  p.), 2-8 weeks p.  p. and 1-2 weeks ante partum, maximal 10 animals/group, pooled samples are useful, optimal are individual samples, use of informative sample substrate and parameters, precise handling of specimens, expert assessment and follow-up. Metabolic controls during 1982-1989 in approximately 242  000 cows revealed means of 32.9% ketoses, 20.0% metabolic acidosis, 21.9% metabolic alkalosis, 34.2% nitrogen-metabolism disorders, 17.3% sodium deficiency and 23.7% liver disorders. Development of a metabolic profile after 1989: Reference values at higher milk yield, early diagnosis of diseases of the fat mobilization syndrome and improved early diagnosis by new indicators, including creatine kinase (CK), alkaline phosphatase (AP) with isoenzymes, acute phase proteins, cytokines, antioxidants, carnitine and lipoprotein fractions, were established. Optimized blood and urine screenings have important advantages over milk analysis. They are an important method of health and performance stabilization by exact analysis of causes and derived prevention. The fertility related parameters free fatty acids, β-hydroxybutyrate, urea, inorganic phosphate, CK, AP, sodium, potassium, selenium, copper, β-carotene and net acid-base excretion proved to be a standard spectrum for screenings. These should be tested once a year/herd, if necessary as

  13. Systematic analysis of funding awarded to institutions in the United Kingdom for infectious disease research, 1997-2010.

    Head, Michael G; Fitchett, Joseph R; Moore, David Aj; Atun, Rifat

    2015-03-01

    This study aimed to assess the research investments made to UK institutions for all infectious disease research and identify the direction of spend by institution. Systematic analysis. Databases and websites were systematically searched for information on relevant studies funded for the period 1997-2010. UK institutions carrying out infectious disease research. None. Twenty academic institutions receiving greatest sum investments across infection are included here, also NHS sites, Sanger Institute, Health Protection Agency and the Medical Research Council. We measured total funding, median award size, disease areas and position of research along the R&D value chain. Included institutions accounted for £2.1 billion across 5003 studies. Imperial College and University of Oxford received the most investment. Imperial College led the most studies. The Liverpool and London Schools of Tropical Medicine had highest median award size, whereas the NHS sites combined had many smaller studies. Sum NHS funding appears to be declining over time, whilst university income is relatively stable. Several institutions concentrate almost exclusively on pre-clinical research. In some areas, there is clearly a leading institution, e.g. Aberdeen and mycology research or UCL and antimicrobial resistance. UK institutions carry out research across a wide range of infectious disease areas. This analysis can identify centres of excellence and help inform future resource allocation for research priorities. Institutions can use this analysis for establishing expertise within their groups, identifying external collaborators and informing local research strategy.

  14. Systematic analysis of funding awarded for norovirus research to institutions in the United Kingdom, 1997-2010.

    Head, Michael G; Fitchett, Joseph R; Atun, Rifat

    2014-03-01

    Norovirus infections pose great economic and disease burden to health systems around the world. This study quantifies the investments in norovirus research awarded to UK institutions over a 14-year time period. A systematic analysis of public and philanthropic infectious disease research investments awarded to UK institutions between 1997 and 2010. None UK institutions carrying out infectious disease research. Total funding for infectious disease research, total funding for norovirus research, position of norovirus research along the R&D value chain. The total dataset consisted of 6165 studies with sum funding of £2.6 billion. Twelve norovirus studies were identified with a total funding of £5.1 million, 0.2% of the total dataset. Of these, eight were categorized as pre-clinical, three as intervention studies and one as implementation research. Median funding was £200,620. Research funding for norovirus infections in the UK appears to be unacceptably low, given the burden of disease and disability produced by these infections. There is a clear need for new research initiatives along the R&D value chain: from pre-clinical through to implementation research, including trials to assess cost-effectiveness of infection control policies as well as clinical, public health and environmental interventions in hospitals, congregate settings and in the community.

  15. Video Release: 47th Vice President of the United States Joseph R. Biden Jr. Speech at HUPO2017 Global Leadership Gala | Office of Cancer Clinical Proteomics Research

    The Human Proteome Organization (HUPO) has released a video of the keynote speech given by the 47th Vice President of the United States of America Joseph R. Biden Jr. at the HUPO2017 Global Leadership Gala. Under the gala theme “International Cooperation in the Fight Against Cancer,” Biden recognized cancer as a collection of related diseases, the importance of data sharing and harmonization, and the need for collaboration across scientific disciplines as inflection points in cancer research.

  16. Design and construction of coal/biomass to liquids (CBTL) process development unit (PDU) at the University of Kentucky Center for Applied Energy Research (CAER)

    Placido, Andrew [Univ. of Kentucky, Lexington, KY (United States); Liu, Kunlei [Univ. of Kentucky, Lexington, KY (United States); Challman, Don [Univ. of Kentucky, Lexington, KY (United States); Andrews, Rodney [Univ. of Kentucky, Lexington, KY (United States); Jacques, David [Univ. of Kentucky, Lexington, KY (United States)

    2015-10-30

    This report describes a first phase of a project to design, construct and commission an integrated coal/biomass-to-liquids facility at a capacity of 1 bbl. /day at the University of Kentucky Center for Applied Energy Research (UK-CAER) – specifically for construction of the building and upstream process units for feed handling, gasification, and gas cleaning, conditioning and compression. The deliverables from the operation of this pilot plant [when fully equipped with the downstream process units] will be firstly the liquid FT products and finished fuels which are of interest to UK-CAER’s academic, government and industrial research partners. The facility will produce research quantities of FT liquids and finished fuels for subsequent Fuel Quality Testing, Performance and Acceptability. Moreover, the facility is expected to be employed for a range of research and investigations related to: Feed Preparation, Characteristics and Quality; Coal and Biomass Gasification; Gas Clean-up/ Conditioning; Gas Conversion by FT Synthesis; Product Work-up and Refining; Systems Analysis and Integration; and Scale-up and Demonstration. Environmental Considerations - particularly how to manage and reduce carbon dioxide emissions from CBTL facilities and from use of the fuels - will be a primary research objectives. Such a facility has required significant lead time for environmental review, architectural/building construction, and EPC services. UK, with DOE support, has advanced the facility in several important ways. These include: a formal EA/FONSI, and permits and approvals; construction of a building; selection of a range of technologies and vendors; and completion of the upstream process units. The results of this project are the FEED and detailed engineering studies, the alternate configurations and the as-built plant - its equipment and capabilities for future research and demonstration and its adaptability for re-purposing to meet other needs. These are described in

  17. Research on structural integration of thermodynamic system for double reheat coal-fired unit with CO2 capture

    Wang, Lanjing; Shao, Wenjing; Wang, Zhiyue; Fu, Wenfeng; Zhao, Wensheng

    2018-02-01

    Taking the MEA chemical absorption carbon capture system with 85% of the carbon capture rate of a 660MW ultra-super critical unit as an example,this paper puts forward a new type of turbine which dedicated to supply steam to carbon capture system. The comparison of the thermal systems of the power plant under different steam supply schemes by using the EBSILON indicated optimal extraction scheme for Steam Extraction System in Carbon Capture System. The results show that the cycle heat efficiency of the unit introduced carbon capture turbine system is higher than that of the usual scheme without it. With the introduction of the carbon capture turbine, the scheme which extracted steam from high pressure cylinder’ s steam input point shows the highest cycle thermal efficiency. Its indexes are superior to other scheme, and more suitable for existing coal-fired power plant integrated post combustion carbon dioxide capture system.

  18. Fat metabolism during exercise in patients with mitochondrial disease

    Jeppesen, Tina Dysgaard; Orngreen, Mette Cathrine; Van Hall, Gerrit

    2009-01-01

    . Fat metabolism was determined by means of indirect calorimetry and stable isotope technique in patients and healthy subjects. Patients carried various types and loads (mean [SE], 72% [5%]) of mitochondrial DNA (mtDNA) mutations in skeletal muscle. All subjects exercised at the same absolute workload......OBJECTIVE: To determine whether patients with defects of the respiratory chain have metabolic adaptations that promote a preferential use of fats or carbohydrates, similar to what is observed in metabolic myopathies affecting glycolysis or fat oxidation. DESIGN: Causation and case-control study...... (mean [SE], 65 [10] W), corresponding to 72% (in patients) and 30% (in healthy subjects) of maximum oxygen consumption. SETTING: Neuromuscular research unit. PARTICIPANTS: Ten patients with mtDNA mutations and 10 sex-matched healthy subjects. MAIN OUTCOME MEASURES: Fat turnover, plasma concentrations...

  19. Multi-Omics Research Trends in Sepsis: A Bibliometric, Comparative Analysis Between the United States, the European Union 28 Member States, and China.

    Evangelatos, Nikolaos; Satyamoorthy, Kapaettu; Levidou, Georgia; Bauer, Pia; Brand, Helmut; Kouskouti, Christina; Lehrach, Hans; Brand, Angela

    2018-03-01

    "-Omics" research is in transition with the recent rise of multi-omics technology platforms. Integration of "-omics" and multi-omics research is of high priority in sepsis, a heterogeneous syndrome that is widely recognized as a global health burden and a priority biomedical funding field. We report here an original study on bibliometric trends in the use of "-omics" technologies, and multi-omics approaches in particular, in sepsis research in three (supra)national settings, the United States, the European Union 28 Member States (EU-28), and China. Using a 5-year longitudinal bibliometric study design from 2011 to 2015, we analyzed the sepsis-related research articles in English language that included at least one or multi-omics technologies in publicly available form in Medline (free full texts). We found that the United States has had the lead (almost one-third of publications) in the inclusion of an "-omics" or multi-omics technology in sepsis within the study period. However, both China and the EU-28 displayed a significant increase in the number of publications that employed one or more types of "-omics" research (p < 0.005), while the EU-28 displayed a significant increase especially in multi-omics research articles in sepsis (p < 0.05). Notably, more than half of the multi-omics research studies in the sepsis knowledge domain had a university or government/state funding source. Among the multi-omics research publications in sepsis, the combination of genomics and transcriptomics was the most frequent (40.5%), followed by genomics and proteomics (20.4%). We suggest that the lead of the United States in the field of "-omics" and multi-omics research in sepsis is likely at stake, with both the EU-28 and China rapidly increasing their research capacity. Moreover, "triple omics" that combine genomics, proteomics, and metabolomics analyses appear to be uncommon in sepsis, and yet much needed for triangulation of systems science data. These observations

  20. Research

    A descriptive qualitative research design was used to determine whether participants ... simulation as a teaching method; a manikin offering effective learning; confidence ..... Tesch R. Qualitative Research: Analysis Types and Software Tools.