HTML5 games creating fun with HTML5, CSS3, and WebGL

CERN Document Server

Seidelin, Jacob

2011-01-01

Discover new opportunities for building 2D and 3D games with HTML5 The newest iteration of HTML, HTML5 can be used with JavaScript, CSS3, and WebGL to create beautiful, unique, engaging games that can be played on the web or mobile devices like the iPad or Android phones. Gone are the days where games were only possible with plugin technologies such as Flash and this cutting-edge book shows you how to utilize the latest open web technologies to create a game from scratch using Canvas, HTML5 Audio, WebGL, and WebSockets. You'll discover how to build a framework on which you will create your HTML5 game. Then each successive chapter covers a new aspect of the game, including user input, sound, multiplayer functionality, 2D and 3D graphics, and more. Aims directly at a new way to develop games for the web through the use of HTML5 Demonstrates how to make iOS and Android web apps Explains how to capture player input; create 3D graphics; and incorporate textures, lighting, and sound Guides you through the proce...

RAZVOJ SPLETNIH APLIKACIJ S HTML5

OpenAIRE

Krajnc, Matej

2012-01-01

V diplomskem delu so predstavljene novosti, ki jih prinaša nov predlog za standard HTML5, obdelane so bistvene razlike med starejšim HTML-standardom in novim HTML5-predlogom, prednosti in slabosti. Bistvena razlika med starejšim standardom in novim predlogom za standard je v sami zgradbi oz. strukturi spletne aplikacije. HTML5 uporablja nove strukturne elemente. V samem HTML-ju ni bilo mogoče prikazati medijev, iger in animacij. HTML5 pa že v osnovi omogoča prikazovanje medijev, iger in ani...

Study of HTML Meta-Tags Utilization in Web-based Open-Access Journals

Directory of Open Access Journals (Sweden)

Pegah Pishva

2007-04-01

Full Text Available The present study investigates the extent of utilization of two meta tags – “keywords” and “descriptors” – in Web-based Open-Access Journals. A sample composed of 707 journals taken from DOAJ was used. These were analyzed on the account of utilization of the said meta tags. Findings demonstrated that these journals utilized “keywords” and “descriptors” meta-tags, 33.1% and 29.9% respectively. It was further demonstrated that among various subject classifications, “General Journals” had been the highest while “Mathematics and Statistics Journals” had the least utilization as “keywords” meta-tags. Moreover, “General Journals” and “Chemistry journals”, with 55.6% and 15.4% utilization respectively, had the highest and the lowest “descriptors” meta-tag usage rate. Based on our findings, and when compared against other similar research findings, there had been no significant growth experienced in utilization of these meta tags.

HTML, XHTML, and CSS Bible

CERN Document Server

Schafer, Steven M

2010-01-01

An essential update to the key web authoring standards of HTML, XHTML, and CSS. The existence of Web pages depends on three vital technologies: HTML (base language that Web pages are written in), XHTML (standards that define how to write HTML pages), and CSS (standard that applies formatting styles to Web pages). This new edition provides you with critical coverage of these three Web authoring standards, and places special focus on the upcoming releases of HTML 5 and CSS 3. Serving as a tutorial and reference, this comprehensive resource explains the basic structure and necessary formatting to

HTML5 Canvas Cookbook

CERN Document Server

Rowell, Eric

2011-01-01

Written in cookbook style, this book offers a wide array of techniques for building HTML5 Canvas applications. Each recipe contains step-by-step instructions followed by analysis of what was done in each task and other useful information. The book is designed so that you can read it chapter by chapter, or you can look at the list of recipes and refer to them in no particular order. This book is geared towards web developers who are familiar with HTML and JavaScript. It is written for both beginners and seasoned HTML5 developers with a good working knowledge of JavaScript.

Mastering HTML5 forms

CERN Document Server

Gupta, Gaurav

2013-01-01

This tutorial will show you how to create stylish forms, not only visually appealing, but interactive and customized, in order to gather valuable user inputs and information.Enhance your skills in building responsive and dynamic web forms using HTML5, CSS3, and related technologies. All you need is a basic understanding of HTML and PHP.

HTML5 data and services cookbook

CERN Document Server

Kosev, Gorgi

2013-01-01

A practical approach with hands on recipes to learn more about HTML5 Data and Services, its features and techniques when building websites or web applications.This book is for programmers and developers who work with a lot of backend code and want to get fast tracked into the world of HTML5 and Javascript. It is also for JavaScript developers who would like to update their knowledge with new techniques and capabilities made possible with HTML5.Some experience in HTML and jQuery is assumed.

HTML5: a new standard for the Web.

Science.gov (United States)

Hoy, Matthew B

2011-01-01

HTML5 is the newest revision of the HTML standard developed by the World Wide Web Consortium (W3C). This new standard adds several exciting news features and capabilities to HTML. This article will briefly discuss the history of HTML standards, explore what changes are in the new HTML5 standard, and what implications it has for information professionals. A list of HTML5 resources and examples will also be provided.

Creating and Viewing HTML Files with Python

OpenAIRE

William J. Turkel; Adam Crymble

2012-01-01

This lesson uses Python to create and view an HTML file. If you write programs that output HTML, you can use any browser to look at your results. This is especially convenient if your program is automatically creating hyperlinks or graphic entities like charts and diagrams. Here you will learn how to create HTML files with Python scripts, and how to use Python to automatically open an HTML file in Firefox.

HTML & CSS The Good Parts

CERN Document Server

Henick, Ben

2010-01-01

HTML and CSS are the workhorses of web design, and using them together to build consistent, reliable web pages requires both skill and knowledge. The task is more difficult if you're relying on outdated, confusing, and unnecessary HTML hacks and workarounds. Author Ben Henick shows you how to avoid those traps by going beyond the standard tips, tricks, and techniques to connect the underlying theory and design of HTML and CSS to your everyday work habits. With this practical book, you'll learn how to work with these tools far more effectively than is standard practice for most web developers

HTML 5 up and running

CERN Document Server

Pilgrim, Mark

2010-01-01

If you don't know about the new features available in HTML5, now's the time to find out. This book provides practical information about how and why the latest version of this markup language will significantly change the way you develop for the Web. HTML5 is still evolving, yet browsers such as Safari, Mozilla, Opera, and Chrome already support many of its features -- and mobile browsers are even farther ahead. HTML5: Up & Running carefully guides you though the important changes in this version with lots of hands-on examples, including markup, graphics, and screenshots. You'll learn how to

Creating and Viewing HTML Files with Python

Directory of Open Access Journals (Sweden)

William J. Turkel

2012-07-01

Full Text Available This lesson uses Python to create and view an HTML file. If you write programs that output HTML, you can use any browser to look at your results. This is especially convenient if your program is automatically creating hyperlinks or graphic entities like charts and diagrams. Here you will learn how to create HTML files with Python scripts, and how to use Python to automatically open an HTML file in Firefox.

HTML5 Media

CERN Document Server

Powers, Shelley

2011-01-01

If you're a web developer or designer familiar with CSS and JavaScript, this tightly focused introduction shows you how to add HTML5 media elements to your web pages, and how to provide custom controls for letting web visitors interact with the content. You'll also learn how to provide subtitles and captions, using file formats that work in browsers now. This book includes code samples and downloadable examples to help you take full advantage of audio and video in your web pages. Ensure your audio or video works in all browsers that support HTML5 media elementsLearn about widely supported me

Head First HTML with CSS & XHTML

CERN Document Server

Robson, Elisabeth

2008-01-01

Tired of reading HTML books that only make sense after you're an expert? Then it's about time you picked up Head First HTML with CSS & XHTML and really learned HTML. You want to learn HTML so you can finally create those web pages you've always wanted, so you can communicate more effectively with friends, family, fans, and fanatic customers. You also want to do it right so you can actually maintain and expand your Web pages over time, and so your web pages work in all the browsers and mobile devices out there. Oh, and if you've never heard of CSS, that's okay - we won't tell anyone you're sti

HTML5 The Missing Manual

CERN Document Server

MacDonald, Matthew

2011-01-01

HTML5 is more than a markup language-it's a dozen independent web standards all rolled into one. Until now, all it's been missing is a manual. With this thorough, jargon-free guide, you'll learn how to build web apps that include video tools, dynamic drawings, geolocation, offline web apps, drag-and-drop, and many other features. HTML5 is the future of the Web, and with this book you'll reach it quickly. The important stuff you need to know: Structure web pages in a new way. Learn how HTML5 helps make web design tools and search engines work smarter.Add audio and video without plugins. Build

The Essential Guide to HTML5 Using Games to Learn HTML5 and JavaScript

CERN Document Server

Meyer, Jeanine

2010-01-01

HTML5 opens up a plethora of new avenues for application and game development on the web. Games can now be created and interacted with directly within HTML with no need for users to download extra plugins, or for developers to learn new languages. Important new features such as the Canvas tag enable drawing directly onto the web page, the Audio tag allows sounds to be triggered and played from within your HTML code, the web sockets API brings the facility for real-time communication, and the local storage API enables data such as high scores or game preferences to be kept on a user's computer

Responsive media in HTML5

CERN Document Server

Libby, Alex

2014-01-01

If you are a web designer with a good understanding of CSS, jQuery, and HTML, but new to creating responsive sites, then this book is for you. The prerequisite is a good understanding of CSS and HTML; the demos will suit those who have some prior knowledge of Less CSS, WordPress, or Bootstrap.

Construction of the automated system on the basis of the platform 1С: enterprise using the JSON format

Directory of Open Access Journals (Sweden)

Fat'yanova A. A.

2018-04-01

Full Text Available options of JSON format using to apply it to integrate with third-party applications is discussed in the article. It is offered to use automated systems on platform 1C Enterprise in a parallel mode.

HTML5 Designing Rich Internet Applications

CERN Document Server

David, Matthew

2010-01-01

Implement the powerful new multimedia and interactive capabilities offered by HTML5, including style control tools, illustration tools, video, audio, and rich media solutions. Understand how HTML5 is changing the Web development game with this full-color, project-based treatment that shows you-not just tells you-what HTML5 can do for your Web sites. Reinforce your practical understanding of the new standard with demo applications and tutorials, so that execution is one short step away. The companion website, visualizetheweb.com, is packed full of extra information, online code libraries, and

Rust types from JSON samples - Approximating type providers with procedural macros in Rust

OpenAIRE

Vesteraas, Erik Andreas

2017-01-01

When programmers access external data in a statically typed programming language, they are often faced with a dilemma between convenient and type-safe access to the data. In the programming language F#, a concept called type providers has been proposed as a solution to this problem by having compiler support for libraries with the capability to generate types at compile time. This thesis presents "json_typegen", a project which aims to show the feasibility of similar solutions in the Rust pro...

HTML5 eLearning kit for dummies

CERN Document Server

Boumphrey, Frank

2012-01-01

Helping self-directed learners of all levels learn HTML5 If you want to develop and structure pages for the web, HTML5 is one of the tools you need. This invaluable eLearning kit steps you through learning HTML5, CSS3, and JavaScript. With this dynamic combination of a full-color printed book and a Dummies interactive eLearning course on CD, you'll find a wealth of information on HTML5. Featuring both written and animated step-by-step how-tos, practice labs, helpful videos, numerous examples, and a host of Dummies hints and tips, this package makes your learning process easier. Follow the mate

HTML5 and CSS3 for dummies

CERN Document Server

Karlins , David

2013-01-01

Learn to create powerful and unique websites with HTML5 and CSS3 HTML5 and CSS3 have ushered in an entirely new era in web development and web design. This easy-to-understand full-color guide presents the elements of design and development as equal; therefore, both designers and developers will benefit from learning how to leverage the power behind HTML5 and CSS3. The two-page spreads and helpful insight show you how to use HTML5 and CSS3 in conjunction in order to create websites that possess both powerful function and beautiful design. Incorporates all the trademark elements of the For Dumm

Beginning HTML5 and CSS3 for dummies

CERN Document Server

Tittel, Ed

2013-01-01

Your full-color, friendly guide to getting started with HTML5 and CSS3! HTML and CSS are essential tools for creating dynamic websites and help make your websites even more effective and unique. This friendly-but-straightforward guide gets you started with the basics of the latest versions of HTML and CSS: HTML5 and CSS3. Introducing you to the syntax and structure of the languages, this helpful guide shows you how to create and view a web page, explains ideal usage of HTML5 and CSS3, walks you through the CSS3 rules and style sheets, addresses common mistakes and explains how to fix them, an

Treating JSON as a subset of XML

NARCIS (Netherlands)

S. Pemberton (Steven)

2012-01-01

textabstractXForms 1.0 was an XML technology originally designed as a replacement for HTML Forms. In addressing certain shortcomings of XForms 1.0, the next version, XForms 1.1 became far more than a forms language, but a declarative application language where application production time could be

Beginning HTML and CSS

CERN Document Server

Larsen, Rob

2013-01-01

Everything you need to build websites with the newest versions of HTML and CSS If you develop websites, you know that the goal posts keep moving, especially now that your website must work on not only traditional desktops, but also on an ever-changing range of smartphones and tablets. This step-by-step book efficiently guides you through the thicket. Teaching you the very latest best practices and techniques, this practical reference walks you through how to use HTML5 and CSS3 to develop attractive, modern websites for today's multiple devices. From handling text, forms, and video,

Instant HTMl5 2D platformer

CERN Document Server

Temple, Aidan

2013-01-01

Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. The step-by-step approach taken by this book will show you how to develop a 2D HTML5 platformer-based game that you will be able to publish to multiple devices.This book is great for anyone who has an interest in HTML5 games development, and who already has a basic to intermediate grasp on both the HTML markup and JavaScript programming languages. Therefore, due to this requirement, the book will not discuss the inner workings of either of these languages but will instead attempt to

Language-Based Caching of Dynamically Generated HTML

DEFF Research Database (Denmark)

Brabrand, Claus; Møller, Anders; Olesen, Steffan

2002-01-01

Increasingly, HTML documents are dynamically generated by interactive Web services. To ensure that the client is presented with the newest versions of such documents it is customary to disable client caching causing a seemingly inevitable performance penalty. In the system, dynamic HTML documents...

HTML5 mobile websites turbocharging HTML5 with jQuery, Sencha Touch, and other frameworks

CERN Document Server

David, Matthew

2013-01-01

Build HTML5-powered mobile web experiences with the aid of development frameworks that speed the development of Native App-like experiences. Build on your foundation of HTML and JavaScript with a complete understanding of the different mobile Web browser technologies. You get carefully detailed techniques that are illustrated in full color so you can leverage the Web technologies unique to each mobile browser, apply frameworks such as Sencha Touch to rapidly build out your designs, and design techniques expressly suited for tablet devices. Projects provide hands-on practice and code is prov

Instant HTML5 fonts and typography

CERN Document Server

Jaouher, K

2013-01-01

Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. Written as practical recipes, Instant HTML5 Fonts and Typography How-to will enable you to use custom fonts with outstanding effects.This book is great for both professional and amateur HTML and CSS developers who are looking to use fonts in order to enhance interface design. Familiarity with JavaScript is assumed.

Sequence alignment visualization in HTML5 without Java.

Science.gov (United States)

Gille, Christoph; Birgit, Weyand; Gille, Andreas

2014-01-01

Java has been extensively used for the visualization of biological data in the web. However, the Java runtime environment is an additional layer of software with an own set of technical problems and security risks. HTML in its new version 5 provides features that for some tasks may render Java unnecessary. Alignment-To-HTML is the first HTML-based interactive visualization for annotated multiple sequence alignments. The server side script interpreter can perform all tasks like (i) sequence retrieval, (ii) alignment computation, (iii) rendering, (iv) identification of a homologous structural models and (v) communication with BioDAS-servers. The rendered alignment can be included in web pages and is displayed in all browsers on all platforms including touch screen tablets. The functionality of the user interface is similar to legacy Java applets and includes color schemes, highlighting of conserved and variable alignment positions, row reordering by drag and drop, interlinked 3D visualization and sequence groups. Novel features are (i) support for multiple overlapping residue annotations, such as chemical modifications, single nucleotide polymorphisms and mutations, (ii) mechanisms to quickly hide residue annotations, (iii) export to MS-Word and (iv) sequence icons. Alignment-To-HTML, the first interactive alignment visualization that runs in web browsers without additional software, confirms that to some extend HTML5 is already sufficient to display complex biological data. The low speed at which programs are executed in browsers is still the main obstacle. Nevertheless, we envision an increased use of HTML and JavaScript for interactive biological software. Under GPL at: http://www.bioinformatics.org/strap/toHTML/.

HTML5 rich media foundation

CERN Document Server

David, Matthew

2010-01-01

Learn about the new ways in which video and audio can be easily embedded into your HTML5 Web pages. Discover how you can create new Web media content and how JavaScript, CSS, and SVG can be integrated to create a compelling, rich media foundation for your work. HTML 5, is the first major update to the core language of the Web in over a decade The focus of this book is on innovations that most directly effect Web site design and multimedia integration The companion Web site features working demonstrations and tutorial media for hands-on pract

Semantic-JSON: a lightweight web service interface for Semantic Web contents integrating multiple life science databases.

Science.gov (United States)

Kobayashi, Norio; Ishii, Manabu; Takahashi, Satoshi; Mochizuki, Yoshiki; Matsushima, Akihiro; Toyoda, Tetsuro

2011-07-01

Global cloud frameworks for bioinformatics research databases become huge and heterogeneous; solutions face various diametric challenges comprising cross-integration, retrieval, security and openness. To address this, as of March 2011 organizations including RIKEN published 192 mammalian, plant and protein life sciences databases having 8.2 million data records, integrated as Linked Open or Private Data (LOD/LPD) using SciNetS.org, the Scientists' Networking System. The huge quantity of linked data this database integration framework covers is based on the Semantic Web, where researchers collaborate by managing metadata across public and private databases in a secured data space. This outstripped the data query capacity of existing interface tools like SPARQL. Actual research also requires specialized tools for data analysis using raw original data. To solve these challenges, in December 2009 we developed the lightweight Semantic-JSON interface to access each fragment of linked and raw life sciences data securely under the control of programming languages popularly used by bioinformaticians such as Perl and Ruby. Researchers successfully used the interface across 28 million semantic relationships for biological applications including genome design, sequence processing, inference over phenotype databases, full-text search indexing and human-readable contents like ontology and LOD tree viewers. Semantic-JSON services of SciNetS.org are provided at http://semanticjson.org.

Evaluation of efficient XML interchange (EXI) for large datasets and as an alternative to binary JSON encodings

OpenAIRE

Hill, Bruce W.

2015-01-01

Approved for public release; distribution is unlimited Current and emerging Navy information concepts, including network-centric warfare and Navy Tactical Cloud, presume high network throughput and interoperability. The Extensible Markup Language (XML) addresses the latter requirement, but its verbosity is problematic for afloat networks. JavaScript Object Notation (JSON) is an alternative to XML common in web applications and some non-relational databases. Compact, binary encodings exist ...

Teach Yourself VISUALLY HTML5

CERN Document Server

Wooldridge, Mike

2011-01-01

Make mark-up language more manageable with this visual guide HTML5 is the next-generation of web standard mark-up language, and among other things, it offers amazing new avenues for incorporating multimedia into your sites. What easier way to master all of HTML5's new bells and whistles than with a guide that shows you, screenshot by screenshot, just what to do? Over a hundred tasks that web designers need to know most are explained using, full-color screenshots and how-to steps. From the easy stuff like revised new header and footer elements to complex updates such as canvas and audio, this

Getting started with HTML5 WebSocket programming

CERN Document Server

Pterneas, Vangos

2013-01-01

Getting Started with HTML5 Websocket Programming takes a tutorial-based approach.This book is for anyone who wants to build high-performance, true, real-time web applications. Being familiar with frontend web development (HTML / XHTML, JavaScript) would be ideal.

JREM: An Approach for Formalising Models in the Requirements Phase with JSON and NoSQL Databases

OpenAIRE

Aitana Alonso-Nogueira; Helia Estévez-Fernández; Isaías García

2017-01-01

This paper presents an approach to reduce some of its current flaws in the requirements phase inside the software development process. It takes the software requirements of an application, makes a conceptual modeling about it and formalizes it within JSON documents. This formal model is lodged in a NoSQL database which is document-oriented, that is, MongoDB, because of its advantages in flexibility and efficiency. In addition, this paper underlines the contributions of the detailed approach a...

HTML5 programming with JavaScript for dummies

CERN Document Server

Mueller, John Paul

2013-01-01

Web designers and programmers, add JavaScript to your HTML5 development toolkit without fear Modern websites are complex, and some of the most exciting features - things like geolocation, canvas, portability to mobile and more - require JavaScript to leverage what HTML5 can create. Don't know JavaScript? That's where HTML5 Programming with JavaScript For Dummies comes in. Rather than walking you through JavaScript as a programming language, it approaches JavaScript as a tool to help you enhance web pages. Helps web designers and programmers tap the full power of HT

High Temperature Materials Laboratory (HTML)

Data.gov (United States)

Federal Laboratory Consortium — The six user centers in the High Temperature Materials Laboratory (HTML), a DOE User Facility, are dedicated to solving materials problems that limit the efficiency...

Pro HTML 5 programming powerful APIs for richer internet application development

CERN Document Server

Lubbers, Peter; Salim, Frank

2010-01-01

HTML5 is here, and with it, web applications take on a power, ease, scalability, and responsiveness like never before. In this book, developers will learn how to use the latest cutting-edge HTML5 web technology - available in the most recent versions of modern browsers - to build web applications with unparalleled functionality, speed, and responsiveness. * Explains how you can create real-time HTML5 applications that tap the full potential of modern browsers * Provides practical, real-world examples of HTML5 features in action * Shows which HTML5 features are supported in current browsers * C

HTML Validation of Context-Free Languages

DEFF Research Database (Denmark)

Møller, Anders; Schwarz, Mathias Romme

2011-01-01

We present an algorithm that generalizes HTML validation of individual documents to work on context-free sets of documents. Together with a program analysis that soundly approximates the output of Java Servlets and JSP web applications as context-free languages, we obtain a method for statically...... checking that such web applications never produce invalid HTML at runtime. Experiments with our prototype implementation demonstrate that the approach is useful: On 6 open source web applications consisting of a total of 104 pages, our tool finds 64 errors in less than a second per page, with 0 false...

Instant migration to HTML5 and CSS3 how-to

CERN Document Server

Kanungo, Dushyant

2013-01-01

Written as a practical guide, ""HTML5 and CSS3 Migration How-to"" will show you all you need to know to effectively publish content that adheres to the latest web standards. This book is for developers and designers who have previous knowledge of HTML (or XHTML) and CSS who could use a helpful yet practical guide in order to migrate their existing content to HTML5 and CSS3. It is also ideal for those who are learning web design and development, as plenty of detailed examples of HTML5 and CSS3 implementations are provided.

Contracts for Cooperation between Web Service Programmers and HTML Designers

DEFF Research Database (Denmark)

Böttger, Henning; Møller, Anders; Schwartzbach, Michael I.

2006-01-01

Interactive Web services consist of a mixture of HTML fragments and program code. The fragments, which are maintained by designers, are combined to form HTML pages that are shown to the clients. The code, which is maintained by programmers, is executed on the server to handle the business logic....... Current Web service frameworks provide little help in separating these constituents, which complicates cooperation between programmers and HTML designers. We propose a system based on XML templates and formalized contracts allowing a flexible separation of concerns. The contracts act as interfaces between...... the programmers and the HTML designers and permit tool support for statically checking that both parties fulfill their obligations. This ensures that (1) programmers and HTML designers work more independently focusing on their own expertises, (2) the Web service implementation is better structured and thus easier...

El uso de la etiqueta META en sitios web de bibliotecas

Directory of Open Access Journals (Sweden)

Senso, José A.

2004-09-01

Full Text Available Positioning techniques are being used increasingly to obtain greater visibility for web sites. One of the tools for reaching this objective is provided by HTML itself: the META tags. This work details how they are developed and implemented, and includes an evaluation of their use by web servers from a sampling of national and international libraries.

Cada vez es más común la utilización de técnicas de posicionamiento para lograr una mayor visibilidad de sitios web. Una de las herramientas para lograr este objetivo la proporciona el propio lenguaje HTML: la etiqueta META. En este trabajo se profundiza en su desarrollo y uso y se evalúa su uso dentro de servidores web de bibliotecas representativas en el ámbito nacional e internacional.

Head First HTML5 Programming Building Web Apps with JavaScript

CERN Document Server

Freeman, Eric

2011-01-01

HTML has been on a wild ride. Sure, HTML started as a mere markup language, but more recently HTML's put on some major muscle. Now we've got a language tuned for building web applications with Web storage, 2D drawing, offline support, sockets and threads, and more. And to speak this language you've got to go beyond HTML5 markup and into the world of the DOM, events, and JavaScript APIs. Now you probably already know all about HTML markup (otherwise known as structure) and you know all aboutCSS style (presentation), but what you've been missing is JavaScript (behavior). If all you know about

HTML5 and CSS3 transition, transformation and animation

CERN Document Server

Guarini, Gianluca Daniele

2013-01-01

Quick and simple example-driven introduction to HTML5 Transitions, Transformations and Animations. Learn by doing to create some simply amazing HTML5 web applications. If you are a web developer or designer and would love to learn and use the game changing technologies included within HTML5 this is the right book for you, start at the beginning and learn some of this technologies awesome features around transitions, transformations and animations. This book is for beginners with transitions, transformations and animations that want a quick and simple kick start using clear and reusable example

Instant HTML5 presentations how-to

CERN Document Server

Ferreira, Davi

2013-01-01

Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. Get the job done and learn as you go. A how-To book with practical recipes accompanied with rich screenshots for easy comprehension.As a Packt Instant, this book aims to provide short, fast and focused information to help you get the results that you need.This book is ideal for those with basic front-end development skills who want to create beautiful HTML5 presentations using the reveal.js library. We assume that you know how to create and edit HTML documents. You also must know ho

HTML5 web application development by example

CERN Document Server

Gustafson, JM

2013-01-01

The best way to learn anything is by doing. The author uses a friendly tone and fun examples to ensure that you learn the basics of application development. Once you have read this book, you should have the necessary skills to build your own applications.If you have no experience but want to learn how to create applications in HTML5, this book is the only help you'll need. Using practical examples, HTML5 Web Application Development by Example will develop your knowledge and confidence in application development.

A Prototype HTML Training System for Graphic Communication Majors

Science.gov (United States)

Runquist, Roger L.

2010-01-01

This design research demonstrates a prototype content management system capable of training graphic communication students in the creation of basic HTML web pages. The prototype serve as a method of helping students learn basic HTML structure and commands earlier in their academic careers. Exposure to the concepts of web page creation early in…

17 CFR 232.105 - Limitation on use of HTML documents and hypertext links.

Science.gov (United States)

2010-04-01

... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Limitation on use of HTML... Requirements § 232.105 Limitation on use of HTML documents and hypertext links. (a) Electronic filers must... exhibits to Form N-SAR in HTML. (b) Electronic filers may not include in any HTML document hypertext links...

The definitive guide to HTML 5 video

CERN Document Server

Pfeiffer, Silvia

2010-01-01

Plugins will soon be a thing of the past. The Definitive Guide to HTML5 Video is the first authoritative book on HTML5 video, the new web standard that allows browsers to support audio and video elements natively. This makes it very easy for web developers to publish audio and video, integrating both within the general presentation of web pages. For example, media elements can be styled using CSS (style sheets), integrated into SVG (scalable vector graphics), and manipulated in a Canvas. The book offers techniques for providing accessibility to media elements, enabling consistent handling of a

HTML5 Geolocation

CERN Document Server

Holdener, Anthony

2011-01-01

Truly revolutionary: now you can write geolocation applications directly in the browser, rather than develop native apps for particular devices. This concise book demonstrates the W3C Geolocation API in action, with code and examples to help you build HTML5 apps using the "write once, deploy everywhere" model. Along the way, you get a crash course in geolocation, browser support, and ways to integrate the API with common geo tools like Google Maps. Learn how geo information is gathered from different sources, depending on the deviceDiscover how coordinate systems work, including geodetic syst

On HTML and XML based web design and implementation techniques

International Nuclear Information System (INIS)

Bezboruah, B.; Kalita, M.

2006-05-01

Web implementation is truly a multidisciplinary field with influences from programming, choosing of scripting languages, graphic design, user interface design, and database design. The challenge of a Web designer/implementer is his ability to create an attractive and informative Web. To work with the universal framework and link diagrams from the design process as well as the Web specifications and domain information, it is essential to create Hypertext Markup Language (HTML) or other software and multimedia to accomplish the Web's objective. In this article we will discuss Web design standards and the techniques involved in Web implementation based on HTML and Extensible Markup Language (XML). We will also discuss the advantages and disadvantages of HTML over its successor XML in designing and implementing a Web. We have developed two Web pages, one utilizing the features of HTML and the other based on the features of XML to carry out the present investigation. (author)

Multiplayer game development with HTML5

CERN Document Server

Silveira, Rodrigo

2015-01-01

If you are a HTML5 game developer who can make basic single-player games and you are now ready to incorporate multiplayer functionality in your games as quickly as possible, then this book is ideal for you.

HTML5 Mobile Development Cookbook

CERN Document Server

Chuan, Shi

2012-01-01

The book is written in a cookbook style, presenting examples in the style of recipes, allowing you to go directly to your topic of interest, or follow topics throughout a chapter to gain in-depth knowledge. Developers keen to create HTML5 mobile websites that are fast and responsive across a whole range of mobile devices.

Building websites with HTML5 to work with mobile phones

CERN Document Server

David, Matthew

2013-01-01

The goal of this ebook is to introduce you to mobile Web development. In many ways it is very similar to desktop Web site development - HTML5 is HTML5 no matter what device you install it on.What is different is how you use and interface with the device. Smartphones and tablets like the iPad, iPhone, and android devices are just very different than laptops and desktops. Find out how to work within mobile versions of popular web browsers while maximizing your design with HTML5 and CSS3 basics. Discover how to place items, work with fonts, and control color detail as well

Integration of HTML documents into an XML-based knowledge repository.

Science.gov (United States)

Roemer, Lorrie K; Rocha, Roberto A; Del Fiol, Guilherme

2005-01-01

The Emergency Patient Instruction Generator (EPIG) is an electronic content compiler / viewer / editor developed by Intermountain Health Care. The content is vendor-licensed HTML patient discharge instructions. This work describes the process by which discharge instructions where converted from ASCII-encoded HTML to XML, then loaded to a database for use by EPIG.

HTML5 for Mobile Applications for Learning

NARCIS (Netherlands)

Glahn, Christian

2011-01-01

Glahn, C. (2011). HTML5 for Mobile Applications for Learning. Presentation held at the Blueteam-Workshop, Bluetea/Stepco-group. February, 21, 2011, Heerlen, The Netherlands: Open University of the Netherlands, CELSTEC.

DOM-based Content Extraction of HTML Documents

National Research Council Canada - National Science Library

Gupta, Suhit; Kaiser, Gail; Neistadt, David; Grimm, Peter

2005-01-01

.... Most approaches to removing clutter or making content more readable involve changing font size or removing HTML and data components such as images, which takes away from a webpage's inherent look and feel...

HTML & XHTML Pocket Reference

CERN Document Server

Robbins, Jennifer

2010-01-01

After years of using spacer GIFs, layers of nested tables, and other improvised solutions for building your web sites, getting used to the more stringent standards-compliant design can be intimidating. HTML and XHTML Pocket Reference is the perfect little book when you need answers immediately. Jennifer Niederst-Robbins, author Web Design in a Nutshell, has revised and updated the fourth edition of this pocket guide by taking the top 20% of vital reference information from her Nutshell book, augmenting it judiciously, cross-referencing everything, and organizing it according to the most com

HTML5, DIGITAL RIGHTS MANAGEMENT (DRM, AND THE RHETORIC OF OPENNESS

Directory of Open Access Journals (Sweden)

Michael S. Daubs

2017-01-01

Full Text Available This paper traces linkages between the commoditisation of the Web and “app-centric media”, an environment composed of a multitude of concrete-but-connected software applications. Within this environment, multiplatform HTML5 apps are often framed as the antithesis of Apple’s iOS and Google/Android “siloed” mobile app platforms, but this rhetoric of openness masks corporate involvement in the development of HTML5 and the commoditisation of the very protocols used to build the Web. To illustrate this process, this paper examines one new element of HTML5 that was hotly debated: the inclusion of digital rights management (DRM protocols. Proponents of DRM in HTML5 argued it would increase overall interoperability while balancing the rights of content creators, providers and users. This paper argues, however, that it instead essentially legitimises U.S.-centric copyright protections on a global scale and allows the future development of the Web to be dominated by a select group of media institutions.

Programming HTML5 Applications Building Powerful Cross-Platform Environments in JavaScript

CERN Document Server

Kessin, Zachary

2011-01-01

HTML5 is not just a replacement for plugins. It also makes the Web a first-class development environment by giving JavaScript programmers a solid foundation for building industrial-strength applications. This practical guide takes you beyond simple site creation and shows you how to build self-contained HTML5 applications that can run on mobile devices and compete with desktop apps. You'll learn powerful JavaScript tools for exploiting HTML5 elements, and discover new methods for working with data, such as offline storage and multithreaded processing. Complete with code samples, this book is

publications.html | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; publications.html. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held from ...

associates.html | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; associates.html. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held from 29–30 ...

Timesheets.js: When SMIL Meets HTML5 and CSS3

OpenAIRE

Cazenave , Fabien; Quint , Vincent; Roisin , Cécile

2011-01-01

International audience; In this paper, we explore different ways to publish multimedia documents on the web. We propose a solution that takes advantage of the new multimedia features of web standards, namely HTML5 and CSS3. To avoid the usual development of complex scripts for handling timing, synchronization and user interaction, we propose to complement HTML5 and CSS3 with SMIL Timesheets. This is made possible by a Timesheets scheduler that runs in the browser. Various applications based o...

SU-E-J-114: Web-Browser Medical Physics Applications Using HTML5 and Javascript.

Science.gov (United States)

Bakhtiari, M

2012-06-01

Since 2010, there has been a great attention about HTML5. Application developers and browser makers fully embrace and support the web of the future. Consumers have started to embrace HTML5, especially as more users understand the benefits and potential that HTML5 can mean for the future.Modern browsers such as Firefox, Google Chrome, and Safari are offering better and more robust support for HTML5, CSS3, and JavaScript. The idea is to introduce the HTML5 to medical physics community for open source software developments. The benefit of using HTML5 is developing portable software systems. The HTML5, CSS, and JavaScript programming languages were used to develop several applications for Quality Assurance in radiation therapy. The canvas element of HTML5 was used for handling and displaying the images, and JavaScript was used to manipulate the data. Sample application were developed to: 1. analyze the flatness and symmetry of the radiotherapy fields in a web browser, 2.analyze the Dynalog files from Varian machines, 3. visualize the animated Dynamic MLC files, 4. Simulation via Monte Carlo, and 5. interactive image manipulation. The programs showed great performance and speed in uploading the data and displaying the results. The flatness and symmetry program and Dynalog file analyzer ran in a fraction of second. The reason behind this performance is using JavaScript language which is a lower level programming language in comparison to the most of the scientific programming packages such as Matlab. The second reason is that JavaScript runs locally on client side computers not on the web-servers. HTML5 and JavaScript can be used to develop useful applications that can be run online or offline on different modern web-browsers. The programming platform can be also one of the modern web-browsers which are mostly open source (such as Firefox). © 2012 American Association of Physicists in Medicine.

Advanced game design with HTML5 and JavaScript

CERN Document Server

van der Spuy, Rex

2015-01-01

How do you make a video game? Advanced Game Design with HTML5 and JavaScript is a down to earth education in how to make video games from scratch, using the powerful HTML5 and JavaScript technologies. This book is a point-by-point round up of all the essential techniques that every game designer needs to know. You'll discover how to create and render game graphics, add interactivity, sound, and animation. You'll learn how to build your own custom game engine with reusable components so that you can quickly develop games with maximum impact and minimum code. You'll also learn the secrets o

From HTML to List of Words (part 2

Directory of Open Access Journals (Sweden)

William J. Turkel

2012-07-01

Full Text Available In this lesson, you will learn the Python commands needed to implement the second part of the algorithm begun in the From HTML to a List of Words (part 1. The first half of the algorithm gets the content of an HTML page and saves only the content that follows the tags. The second half of the algorithm does the following: Look at every character in the pageContents string, one character at a time If the character is a left angle bracket ( we are now leaving the tag; ignore the current character, but look at each following character If we’re not inside a tag, append the current character to a new variable: text Split the text string into a list of individual words that can later be manipulated further.

Dynamic HTML The Definitive Reference

CERN Document Server

Goodman, Danny

2007-01-01

Packed with information on the latest web specifications and browser features, this new edition is your ultimate one-stop resource for HTML, XHTML, CSS, Document Object Model (DOM), and JavaScript development. Here is the comprehensive reference for designers of Rich Internet Applications who need to operate in all modern browsers, including Internet Explorer 7, Firefox 2, Safari, and Opera. With this book, you can instantly see browser support for the latest standards-based technologies, including CSS Level 3, DOM Level 3, Web Forms 2.0, XMLHttpRequest for AJAX applications, JavaScript 1.7

Practical Implementation of 10 Rules for Writing REST APIs

Directory of Open Access Journals (Sweden)

Jiri Hradil

2017-01-01

Full Text Available This paper shows a practical implementation of “10 Rules for Writing REST APIs introduced in the article” (Hradil, 2016. The application is done in Invoice Home (Wikilane, 2016, an invoicing web application for small business and entrepreneurs available world-wide. The API is implemented in JSON hypermedia format (ECMA International, 2016 and with Ruby on Rails framework (Hansson, 2016. The main purpose of the API is to allow connection of Invoice Home with external systems and offer Invoice Home data in simpler format compared to the current HTML format of the full-stack web application. The paper could be also used as a basic template or pattern for any other implementation of the JSON API in any web-based application.

Open chemistry: RESTful web APIs, JSON, NWChem and the modern web application.

Science.gov (United States)

Hanwell, Marcus D; de Jong, Wibe A; Harris, Christopher J

2017-10-30

An end-to-end platform for chemical science research has been developed that integrates data from computational and experimental approaches through a modern web-based interface. The platform offers an interactive visualization and analytics environment that functions well on mobile, laptop and desktop devices. It offers pragmatic solutions to ensure that large and complex data sets are more accessible. Existing desktop applications/frameworks were extended to integrate with high-performance computing resources, and offer command-line tools to automate interaction-connecting distributed teams to this software platform on their own terms. The platform was developed openly, and all source code hosted on the GitHub platform with automated deployment possible using Ansible coupled with standard Ubuntu-based machine images deployed to cloud machines. The platform is designed to enable teams to reap the benefits of the connected web-going beyond what conventional search and analytics platforms offer in this area. It also has the goal of offering federated instances, that can be customized to the sites/research performed. Data gets stored using JSON, extending upon previous approaches using XML, building structures that support computational chemistry calculations. These structures were developed to make it easy to process data across different languages, and send data to a JavaScript-based web client.

Adobe acrobat: an alternative electronic teaching file construction methodology independent of HTML restrictions.

Science.gov (United States)

Katzman, G L

2001-03-01

The goal of the project was to create a method by which an in-house digital teaching file could be constructed that was simple, inexpensive, independent of hypertext markup language (HTML) restrictions, and appears identical on multiple platforms. To accomplish this, Microsoft PowerPoint and Adobe Acrobat were used in succession to assemble digital teaching files in the Acrobat portable document file format. They were then verified to appear identically on computers running Windows, Macintosh Operating Systems (OS), and the Silicon Graphics Unix-based OS as either a free-standing file using Acrobat Reader software or from within a browser window using the Acrobat browser plug-in. This latter display method yields a file viewed through a browser window, yet remains independent of underlying HTML restrictions, which may confer an advantage over simple HTML teaching file construction. Thus, a hybrid of HTML-distributed Adobe Acrobat generated WWW documents may be a viable alternative for digital teaching file construction and distribution.

基于HTML5+jQuery Mobile的移动Web应用开发研究%Study of mobile web application development based on HTML5 and jQuery Mobile

Institute of Scientific and Technical Information of China (English)

覃凤萍

2015-01-01

With the rapidly growing popularity of smart devices such as iphone and Android,mobile web technology has gradually become a new hot spot of concern,traditional site will be transferred to the mobile terminal due to market demand . Using jQuery Mobile and HTML5 to do mobile web application development, with the development of simple, short release cycle, cross-platform, cross-platform advantages . In this paper, jQuery Mobile and HTML5 mobile web application development made a presentation and analysis.%随着iphone、Android等智能设备的迅速普及，移动Web技术逐渐成为关注的新热点，传统信息类和电子商务网站因市场需求向移动终端转移。使用jQuery Mobile和HTML5做移动Web应用开发，具有开发简单，发布周期短、跨平台跨设备的优点。文章对jQuery Mobile和HTML5的移动Web应用开发做了介绍和分析。

Instant HTML5 geolocation how-to

CERN Document Server

Werdmuller, Ben

2013-01-01

Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. The book will take a how-to approach, focusing on recipes that demonstrate geolocation in HTML5.This book is for web developers who want to incorporate geolocation technology into their applications. Previous knowledge about geolocation software or standards is not required. However, this book assumes a general understanding of web technologies, and both Javascript and jQuery in particular.

HTML5 game programming with enchant.js

CERN Document Server

Shimizu, Ryo; Fushimi, Ryohei; Tanaka, Ryo; Kratzer, Kevin; McInnis, Brandon; Inc, enchantjs

2013-01-01

Official book from the developers of enchant.js. Enchant.js is open source, so there is no barrier for entry. Provides aspiring game developers with a tool to program fully-fledged games quickly and easily. Teaches the basics of HTML5 and JavaScript, invaluable tools for budding programmers. Shares invaluable tips from professional game developers for creating compelling game design and content.

Beginning iOS Application Development with HTML and JavaScript

CERN Document Server

Wagner, Richard

2012-01-01

Web developers with HTML/JS skills will quickly learn to apply them to the iPhone/iPad platform Beginning to intermediate web developers who want to apply their existing HTML/CSS/JS/Ajax skills to the wildly popular iPhone/iPad OS will love this book. In the highly successful Wrox Beginning format, it enables developers who know these core technologies to use what they already know and get up to speed quickly. It introduces iOS development with web technologies, explains how to enable and optimize web sites for the iPhone and iPad, explores user interface design, then moves into animation, spe

Head First jQuery

CERN Document Server

Benedetti, Ryan

2011-01-01

Want to add more interactivity and polish to your websites? Discover how jQuery can help you build complex scripting functionality in just a few lines of code. With Head First jQuery, you'll quickly get up to speed on this amazing JavaScript library by learning how to navigate HTML documents while handling events, effects, callbacks, and animations. By the time you've completed the book, you'll be incorporating Ajax apps, working seamlessly with HTML and CSS, and handling data with PHP, MySQL and JSON. If you want to learn-and understand-how to create interactive web pages, unobtrusive scrip

A browser-based tool for conversion between Fortran NAMELIST and XML/HTML

Science.gov (United States)

Naito, O.

A browser-based tool for conversion between Fortran NAMELIST and XML/HTML is presented. It runs on an HTML5 compliant browser and generates reusable XML files to aid interoperability. It also provides a graphical interface for editing and annotating variables in NAMELIST, hence serves as a primitive code documentation environment. Although the tool is not comprehensive, it could be viewed as a test bed for integrating legacy codes into modern systems.

A browser-based tool for conversion between Fortran NAMELIST and XML/HTML

Directory of Open Access Journals (Sweden)

O. Naito

2017-01-01

Full Text Available A browser-based tool for conversion between Fortran NAMELIST and XML/HTML is presented. It runs on an HTML5 compliant browser and generates reusable XML files to aid interoperability. It also provides a graphical interface for editing and annotating variables in NAMELIST, hence serves as a primitive code documentation environment. Although the tool is not comprehensive, it could be viewed as a test bed for integrating legacy codes into modern systems.

A profile of the future: what could HTML 5 do for HE by 2015?

Directory of Open Access Journals (Sweden)

Rick Ogden

2012-08-01

Full Text Available HTML 5 is the most significant update of HTML in the last 10 years since XHTML was introduced. It promises a vastly improved user experience, increased browser features, cross compatibility and the ability to provide semantic content. In this paper we discuss the near future position for Higher Education in terms of technological transform, the proposed capabilities of HTML 5, and how they may change and how virtual learning environments are implemented in the future. We offer a set of education-based scenarios and how the emerging standard could benefit them. Finally we conclude with possible implementation timescales.

Evaluation of the Applicability of HTML5 for Mobile Applications in Resource-Constrained Edge Environments

Science.gov (United States)

2014-07-01

fully supported by the HTML5 standard via the HTML5 File API drafted by W3C [ Ranganathan 2013]. Figure 6 shows a JavaScript code example that...W3C). May 2012. http://dev.w3.org/geo/api/spec-source.html [Pusher 2012] Pusher Ltd. Pusher. http://pusher.com (2012). [ Ranganathan 2013... Ranganathan , Arun & Sicking, Jonas. “File API.” World Wide Web Consortium (W3C). 2013. http://www.w3.org/TR/FileAPI/ [Regmi 2011] Regni,Saroj Sharan

HTML5 iPhone application development

CERN Document Server

Crespo, Alvin

2013-01-01

Presented in an easy to follow, step by step tutorial format, this is your guide to web application development for the iOS Safari.This book was meant for you! From the beginner developer to chief technology officer, this book aims to make you an expert in the field of web application development for iOS Safari. Familiarity with HTML, CSS and JavaScript are greatly encouraged but if you're looking to dive right in and find solutions to everyday problems and more, then this book is for you.

A FRAMEWORK FOR ONLINE SPATIO-TEMPORAL DATA VISUALIZATION BASED ON HTML5

Directory of Open Access Journals (Sweden)

B. Mao

2012-07-01

Full Text Available Web is entering a new phase – HTML5. New features of HTML5 should be studied for online spatio-temporal data visualization. In the proposed framework, spatio-temporal data is stored in the data server and is sent to user browsers with WebSocket. Public geo-data such as Internet digital map is integrated into the browsers. Then animation is implemented through the canvas object defined by the HTML5 specification. To simulate the spatio-temporal data source, we collected the daily location of 15 users with GPS tracker. The current positions of the users are collected every minute and are recorded in a file. Based on this file, we generate a real time spatio-temporal data source which sends out current user location every second.By enlarging the real time scales by 60 times, we can observe the movement clearly. The data transmitted with WebSocket is the coordinates of users' current positions, which will can be demonstrated in client browsers.

A Profile of the Future: What Could HTML 5 Do for HE by 2015?

Science.gov (United States)

Griffiths, Lee Scott; Ogden, Rick; Aspin, Rob

2012-01-01

HTML 5 is the most significant update of HTML in the last 10 years since XHTML was introduced. It promises a vastly improved user experience, increased browser features, cross compatibility and the ability to provide semantic content. In this paper we discuss the near future position for Higher Education in terms of technological transform, the…

HTML, XHTML, and CSS All-in-One Desk Reference for Dummies

CERN Document Server

Harris, Andy

2008-01-01

Want to build a killer Web site? Want to make it easy to keep your site up to date? You'll need to know how CSS, HTML, and XHTML work together. HTML, XHTML, and CSS All-In-One Desk Reference For Dummies makes that easy too! These eight minibooks get you started, explain standards, and help you connect all the dots to create sites with pizzazz. This handy, one-stop guide catches you up on XHTML basics and CSS fundamentals. You'll learn how to work with Positionable CSS to create floating elements, margins, and multi-column layouts, and you'll get up to speed on client-side programming with Java

A programmable rules engine to provide clinical decision support using HTML forms.

Science.gov (United States)

Heusinkveld, J; Geissbuhler, A; Sheshelidze, D; Miller, R

1999-01-01

The authors have developed a simple method for specifying rules to be applied to information on HTML forms. This approach allows clinical experts, who lack the programming expertise needed to write CGI scripts, to construct and maintain domain-specific knowledge and ordering capabilities within WizOrder, the order-entry and decision support system used at Vanderbilt Hospital. The clinical knowledge base maintainers use HTML editors to create forms and spreadsheet programs for rule entry. A test environment has been developed which uses Netscape to display forms; the production environment displays forms using an embedded browser.

Web design with HTML and CSS

CERN Document Server

Osborn, Jeremy

2011-01-01

"An invaluable full-color training package for Web design Web design consists of using multiple software tools and codes-such as Dreamweaver, Flash, Silverlight, Illustrator, Photoshop, HTML, and CSS, among others-to craft a unique, robust, and interactive websites. This book teaches you how to effectively use all the major tools involved in web design to create a site that is both attractive and functional. You'll go beyond the basics to learn best practices of good web design so you can go from the drawing board to a successful site. Combining full-color, step-by-step instructions with lesso

Using the HTML5 Filesystem API

CERN Document Server

Bidelman, Eric

2011-01-01

Several client-side storage options are available to web applications, but one area that's been lacking until now is file I/O-the ability to organize binary data into a true hierarchy of folders. That has changed with the advent of HTML5. With this book, you'll learn how to provide your applications with a file system that enables them to create, read, and write files and folders in a sandboxed section of the user's local filesystem. Author Eric Bidelman, a Senior Developer Programs Engineer on the Google Chrome team, provides several techniques and complete code examples for working with th

Developing a distributed HTML5-based search engine for geospatial resource discovery

Science.gov (United States)

ZHOU, N.; XIA, J.; Nebert, D.; Yang, C.; Gui, Z.; Liu, K.

2013-12-01

With explosive growth of data, Geospatial Cyberinfrastructure(GCI) components are developed to manage geospatial resources, such as data discovery and data publishing. However, the efficiency of geospatial resources discovery is still challenging in that: (1) existing GCIs are usually developed for users of specific domains. Users may have to visit a number of GCIs to find appropriate resources; (2) The complexity of decentralized network environment usually results in slow response and pool user experience; (3) Users who use different browsers and devices may have very different user experiences because of the diversity of front-end platforms (e.g. Silverlight, Flash or HTML). To address these issues, we developed a distributed and HTML5-based search engine. Specifically, (1)the search engine adopts a brokering approach to retrieve geospatial metadata from various and distributed GCIs; (2) the asynchronous record retrieval mode enhances the search performance and user interactivity; (3) the search engine based on HTML5 is able to provide unified access capabilities for users with different devices (e.g. tablet and smartphone).

Design of Distance Teaching Live Broadcast System Based on VNC and HTML5 Technology%基于VNC和HTML5技术的远程教学直播系统设计

Institute of Scientific and Technical Information of China (English)

岳峰

2012-01-01

采用VNC和HTML5技术,构建了远程教学直播系统.该系统可实现教师计算机屏幕内容的直播,用户可以使用支持HTML5标准的浏览器访问该系统网站而无需安装任何插件.

TOPS On-Line: Automating the Construction and Maintenance of HTML Pages

Science.gov (United States)

Jones, Kennie H.

1994-01-01

After the Technology Opportunities Showcase (TOPS), in October, 1993, Langley Research Center's (LaRC) Information Systems Division (ISD) accepted the challenge to preserve the investment in information assembled in the TOPS exhibits by establishing a data base. Following the lead of several people at LaRC and others around the world, the HyperText Transport Protocol (HTTP) server and Mosaic were the obvious tools of choice for implementation. Initially, some TOPS exhibitors began the conventional approach of constructing HyperText Markup Language (HTML) pages of their exhibits as input to Mosaic. Considering the number of pages to construct, a better approach was conceived that would automate the construction of pages. This approach allowed completion of the data base construction in a shorter period of time using fewer resources than would have been possible with the conventional approach. It also provided flexibility for the maintenance and enhancement of the data base. Since that time, this approach has been used to automate construction of other HTML data bases. Through these experiences, it is concluded that the most effective use of the HTTP/Mosaic technology will require better tools and techniques for creating, maintaining and managing the HTML pages. The development and use of these tools and techniques are the subject of this document.

Supercharged JavaScript Graphics with HTML5 canvas, jQuery, and More

CERN Document Server

Cecco, Raffaele

2011-01-01

With HTML5 and improved web browser support, JavaScript has become the tool of choice for creating high-performance web graphics. This faced-paced book shows you how to use JavaScript, jQuery, DHTML, and HTML5's Canvas element to create rich web applications for computers and mobile devices. By following real-world examples, experienced web developers learn fun and useful approaches to arcade games, DHTML effects, business dashboards, and other applications. This book serves complex subjects in easily digestible pieces, and each topic acts as a foundation for the next. Tackle JavaScript opti

Dreamweaver CS6 HTML5, CSS3, responsive design, and jQuery

CERN Document Server

Karlins, David

2013-01-01

This book combines accessible, clear, engaging, and candid reference material, advice, and shortcuts with substantial stepbystep instructions for creating a wide range of HTML5 and CSS3 designs and page content in Dreamweaver.This book is geared towards experienced Dreamweaver web designers migrating to HTML5 and jQuery. It also targets web designers new to Dreamweaver who want to jump with two feet into the most current web design tools and features. While focused primarily on Dreamweaver CS5.5, the book includes content of value to readers using older versions of Dreamweaver with directions

Mobile first design with HTML5 and CSS3

CERN Document Server

Gonzalez, Jason

2013-01-01

A user friendly tutorial to develop websites that work for both small and large screens using HTML5 and CSS3.This book is for beginner to intermediate developers and designers, as well as for those in management who want to understand what is possible with modern tools and strategies on the Web.

Verkkoselainten vertailu ja HTML5-teknologian tuki

OpenAIRE

Nevanperä, Joni

2012-01-01

Opinnäytetyön tarkoituksena on tutustua kolmen eri verkkoselaimeen. Tutkittavat verkkoselaimet ovat Mozillan Firefox, Googlen Chrome ja Microsoftin Internet Explorer. Opinnäytetyössä tutkitaan myös kuinka nämä selaimet tukevat HTML5-teknologiaa. Opinnäytetyö selvittää verkkoselainten yhteistä historiaa ja niiden yleiset ominaisuudet. Verkkoselaimista tehdään myös tarkempi analyysi. Tämä sisältää kuvauksen selaimen kehittäjästä, selaimen kehityshistorian ja esittelyn selaimen ominaisuuksis...

A digital imaging teaching file by using the internet, HTML and personal computers

International Nuclear Information System (INIS)

Chun, Tong Jin; Jeon, Eun Ju; Baek, Ho Gil; Kang, Eun Joo; Baik, Seung Kug; Choi, Han Yong; Kim, Bong Ki

1996-01-01

A film-based teaching file takes up space and the need to search through such a file places limits on the extent to which it is likely to be used. Furthermore it is not easy for doctors in a medium-sized hospital to experience a variety of cases, and so for these reasons we created an easy-to-use digital imaging teaching file with HTML(Hypertext Markup Language) and downloaded images via World Wide Web(WWW) services on the Internet. This was suitable for use by computer novices. We used WWW internet services as a resource for various images and three different IMB-PC compatible computers(386DX, 486DX-II, and Pentium) in downloading the images and in developing a digitalized teaching file. These computers were connected with the Internet through a high speed dial-up modem(28.8Kbps) and to navigate the Internet. Twinsock and Netscape were used. 3.0, Korean word processing software, was used to create HTML(Hypertext Markup Language) files and the downloaded images were linked to the HTML files. In this way, a digital imaging teaching file program was created. Access to a Web service via the Internet required a high speed computer(at least 486DX II with 8MB RAM) for comfortabel use; this also ensured that the quality of downloaded images was not degraded during downloading and that these were good enough to use as a teaching file. The time needed to retrieve the text and related images depends on the size of the file, the speed of the network, and the network traffic at the time of connection. For computer novices, a digital image teaching file using HTML is easy to use. Our method of creating a digital imaging teaching file by using Internet and HTML would be easy to create and radiologists with little computer experience who want to study various digital radiologic imaging cases would find it easy to use

RAPID and HTML5's potential

Science.gov (United States)

Torosyan, David

2012-01-01

Just as important as the engineering that goes into building a robot is the method of interaction, or how human users will use the machine. As part of the Human-System Interactions group (Conductor) at JPL, I explored using a web interface to interact with ATHLETE, a prototype lunar rover. I investigated the usefulness of HTML 5 and Javascript as a telemetry viewer as well as the feasibility of having a rover communicate with a web server. To test my ideas I built a mobile-compatible website and designed primarily for an Android tablet. The website took input from ATHLETE engineers, and upon its completion I conducted a user test to assess its effectiveness.

Benefits and Pitfalls of Using HTML5 APIs for Online Experiments and Simulations

Directory of Open Access Journals (Sweden)

Pablo Garaizar

2012-11-01

Full Text Available The most recent advances in the architecture of the Web allow using it as an excellent platform to deliver experiments and simulations over the Internet. However, there are still some challenges related to the animations’ accuracy, to user input collection or to real-time communications that have to be accomplished to properly port native application- based experiments and simulations to the Web. The limitations of the standards preceding HTML5 have forced web developers to embed non-HTML objects using a wide range of non-standard plugins and causing an extremely fragmented execution environment where features must be implemented several times in different programming languages to guarantee full compliance with every user-agent. As HTML5 provides a standard -yet fully-featured- environment to develop and execute applications, web user-agents are now more similar to application players than to simple Internet browsers. In this paper we analyze the benefits and pitfalls of these new Application Programming Interfaces (APIs, providing examples of both good and bad instances of research-related use.

Generic HTML Form Processor: A versatile PHP script to save web-collected data into a MySQL database.

Science.gov (United States)

Göritz, Anja S; Birnbaum, Michael H

2005-11-01

The customizable PHP script Generic HTML Form Processor is intended to assist researchers and students in quickly setting up surveys and experiments that can be administered via the Web. This script relieves researchers from the burdens of writing new CGI scripts and building databases for each Web study. Generic HTML Form Processor processes any syntactically correct HTML forminput and saves it into a dynamically created open-source database. We describe five modes for usage of the script that allow increasing functionality but require increasing levels of knowledge of PHP and Web servers: The first two modes require no previous knowledge, and the fifth requires PHP programming expertise. Use of Generic HTML Form Processor is free for academic purposes, and its Web address is www.goeritz.net/brmic.

HTML5 and CSS3 responsive web design cookbook

CERN Document Server

LaGrone, Benjamin

2013-01-01

As a Cookbook, we are targeting existing developers who need to pick and choose specific recipes in order to help their websites become accessible (and usable) regardless of screen size, device, or browser.HTML5 and CSS3 Responsive Web Design Cookbook, for all of today's wireless Internet devices, is for web developers seeking innovative techniques that deliver fast, intuitive interfacing for the latest mobile Internet devices.

Building HTML5 games with ImpactJS an introduction on HTML5 game development

CERN Document Server

Freeman, Jesse

2012-01-01

Create a real 2D game from start to finish with ImpactJS, the JavaScript game framework that works with the HTML5's Canvas element. Making video games is hard work that requires technical skills, a lot of planning, and-most critically-a commitment to completing the project. With this hands-on guide, you'll learn how to use Impact with other technologies step-by-step. You'll pick up important tips about game design, and discover how to publish Impact games to the Web, desktop, and mobile-including a method to package your game as a native iOS app. Packed with screen shots and sample code, this book is ideal for game developers of all levels. Set up your development environment and discover Impact's advantagesBuild a complete game with core logic, collision detection, and player and monster behaviorLearn why a game design document is critical before you start buildingDisplay and animate game artwork with sprite sheetsAdd sound effects, background music, and textCreate screens to display stats and in-game statu...

SGML/XML to HTML Conversion System and Method for Frame-Based Viewer

National Research Council Canada - National Science Library

Lepore, Marcus A

2008-01-01

..., such as with Java or JavaScript. A parser allows for multi-layered HTML documents comprised of dynamically sizing framesets which combines transformed SGML and external components such as graphics multimedia with executable mini...

Responsive Web Design with HTML5 and CSS3

CERN Document Server

Frain, Ben

2012-01-01

This book will lead you, step by step and with illustrative screenshots, through a real example. Are you writing two websites - one for mobile and one for larger displays? Or perhaps you've heard of Responsive Design but are unsure how to bring HTML5, CSS3, or responsive design all together. If so, this book provides everything you need to take your web pages to the next level - before all your competitors do!

index body.html | sep2000 | jess | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; jess; sep2000; index body.html. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be ...

index body.html | sep2002 | jess | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; jess; sep2002; index body.html. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be ...

texreg: Conversion of Statistical Model Output in R to LATEX and HTML Tables

Directory of Open Access Journals (Sweden)

Philip Leifeld

2013-11-01

Full Text Available A recurrent task in applied statistics is the (mostly manual preparation of model output for inclusion in LATEX, Microsoft Word, or HTML documents usually with more than one model presented in a single table along with several goodness-of-fit statistics. However, statistical models in R have diverse object structures and summary methods, which makes this process cumbersome. This article first develops a set of guidelines for converting statistical model output to LATEX and HTML tables, then assesses to what extent existing packages meet these requirements, and finally presents the texreg package as a solution that meets all of the criteria set out in the beginning. After providing various usage examples, a blueprint for writing custom model extensions is proposed.

Canvas Pocket Reference Scripted Graphics for HTML5

CERN Document Server

Flanagan, David

2010-01-01

The Canvas element is a revolutionary feature of HTML5 that enables powerful graphics for rich Internet applications, and this pocket reference provides the essentials you need to put this element to work. If you have working knowledge of JavaScript, this book will help you create detailed, interactive, and animated graphics -- from charts to animations to video games -- whether you're a web designer or a programmer interested in graphics. Canvas Pocket Reference provides both a tutorial that covers all of the element's features with plenty of examples and a definitive reference to each of t

The definitive guide to HTML5 WebSocket

CERN Document Server

Wang, Vanessa; Moskovits, Peter

2013-01-01

The Definitive Guide to HTML5 WebSocket is the ultimate insider's WebSocket resource. This revolutionary new web technology enables you to harness the power of true real-time connectivity and build responsive, modern web applications.   This book contains everything web developers and architects need to know about WebSocket. It discusses how WebSocket-based architectures provide a dramatic reduction in unnecessary network overhead and latency compared to older HTTP (Ajax) architectures, how to layer widely used protocols such as XMPP and STOMP on top of WebSocket, and how to secure WebSocket c

Renaissance of the Web

Science.gov (United States)

McCarty, M.

2009-09-01

The renaissance of the web has driven development of many new technologies that have forever changed the way we write software. The resulting tools have been applied to both solve problems and creat new ones in a wide range of domains ranging from monitor and control user interfaces to information distribution. This discussion covers which of and how these technologies are being used in the astronomical computing community. Topics include JavaScript, Cascading Style Sheets, HTML, XML, JSON, RSS, iCalendar, Java, PHP, Python, Ruby on Rails, database technologies, and web frameworks/design patterns.

Fetching and Parsing Data from the Web with OpenRefine

Directory of Open Access Journals (Sweden)

Evan Peter Williamson

2017-08-01

Full Text Available OpenRefine is a powerful tool for exploring, cleaning, and transforming data. An earlier Programming Historian lesson, “Cleaning Data with OpenRefine”, introduced the basic functionality of Refine to efficiently discover and correct inconsistency in a data set. Building on those essential data wrangling skills, this lesson focuses on Refine’s ability to fetch URLs and parse web content. Examples introduce some of the advanced features to transform and enhance a data set including: - fetch URLs using Refine - construct URL queries to retrieve information from a simple web API - parse HTML and JSON responses to extract relevant data - use array functions to manipulate string values - use Jython to extend Refine’s functionality It will be helpful to have basic familiarity with OpenRefine, HTML, and programming concepts such as variables and loops to complete this lesson.

HTML5 paikkatietojen hyödyntäminen mobiilimainonnassa

OpenAIRE

Yrjönen, Tuuli

2012-01-01

Opinnäytetyön tarkoituksena oli tutkia HTML5 paikkatietojen käyttöä mobiilimainonnassa. Tavoitteena oli selvittää, mitä mahdollisuuksia paikkatietojen hyödyntämisellä on mainonnan näkökulmasta, sillä paikkasidonnaiset palvelut ovat jo hyvin yleisiä. Lisäksi tavoitteena oli tutkia paikkasidonnaisen mainonnan vaihtoehtoja; mitkä siihen liittyvät rajoitukset ja haasteet ovat ja mitä mahdollisuuksia paikkatietojen hyödyntämiseen mainonnassa tulevaisuudessa on. Opinnäytetyötä varten testattiin ...

Pro Android Web Apps Develop for Android Using HTML5, CSS3 and JavaScript

CERN Document Server

Oehlman, Damon

2011-01-01

Developing applications for Android and other mobile devices using web technologies is now well within reach. When the capabilities of HTML5 are combined with CSS3 and JavaScript, web application developers have an opportunity to develop compelling mobile applications using familiar tools. Not only is it possible to build mobile web apps that feel as good as native apps, but to also write an application once and have it run a variety of different devices. While the HTML5 specification is still evolving, there is a lot that can be used right now to build mobile web apps. Mobile web apps are now

FPGA Based Low Power DES Algorithm Design And Implementation using HTML Technology

DEFF Research Database (Denmark)

Thind, Vandana; Pandey, Bishwajeet; Kalia, Kartik

2016-01-01

In this particular work, we have done power analysis of DES algorithm implemented on 28nm FPGA using HTML (H-HSUL, T-TTL, M-MOBILE_DDR, L-LVCMOS) technology. In this research, we have used high performance software Xilinx ISE where we have selected four different IO Standards i.e. MOBILE_DDR, HSUL...

HTML5: computación en la nube (presentación)

OpenAIRE

Luján Mora, Sergio

2011-01-01

HTML5: Computación en la nube. Qué es, ventajas y desventajas. - Principales ventajas: - Accede a tus aplicaciones y datos desde cualquier sitio - Olvídate de las versiones - Utiliza tus aplicaciones y datos desde cualquier dispositivo con un navegador - No te preocupes por tu ordenador - No te preocupes por las copias de seguridad - Olvídate de los virus y otras amenazas.

A Study of HTML Title Tag Creation Behavior of Academic Web Sites

Science.gov (United States)

Noruzi, Alireza

2007-01-01

The HTML title tag information should identify and describe exactly what a Web page contains. This paper analyzes the "Title element" and raises a significant question: "Why is the title tag important?" Search engines base search results and page rankings on certain criteria. Among the most important criteria is the presence of the search keywords…

Developing Windows Store apps with HTML5 and JavaScript

CERN Document Server

Sarieddine, Rami

2013-01-01

This book is a hands-on guide that follows a step-by-step tutorial approach which discusses Windows 8 application development with HTML5, CSS3, and JavaScript.This book is great for developers who want to start developing for Windows 8 and it also targets developers who want to get introduced to powerful advancements in standards-based web technology, while using it to build Windows Store apps, as well as leveraging their existing skills and code assets in web development.

HTML, CSS, and JavaScript Mobile Development For Dummies

CERN Document Server

Harrel, William

2011-01-01

Learn to build and optimize attractive, functional web sites for smartphones Today, mobile devices outnumber desktop and laptop computers three to one. Skill in developing web sites that work on mobile devices is in demand, and this friendly, step-by-step guide shows how to build and optimize sites using HTML5 and other standard web development tools. Building web sites that work for all types of smartphones and tablets, including iPhones, iPads, Android devices, and BlackBerry devices is a skill much in demand as mobile devices outpace both desktop and laptop computers, and this book gets yo

Self-study program on HTML browser--application to Clinical Nursing General Remarks Course.

Science.gov (United States)

Ochiai, N; Sota, Y; Ezumi, H

1997-01-01

We created a self-study program using HTML browser on the Clinical Nursing General Remarks Course, Eighty-three students each selected a published book on a personal history (written personal reflections from individuals who had undergone medical treatment and hospitalization), read it and submitted reports of their impressions of the histories. Their reports were arranged from a nursing perspective and entered on the home page of our college using HTML browser. We intended that the students would become more interested in reading of the personal histories, and that they would acquire new self-study skills and increase their interest in Internet through use of our program. In addition, we hoped that this program would encourage positive communication and mutual sharing of information. The students were able to easily refer to a personal history according to their interest from a nursing perspective. Therefore this program realized the mutual learning among students and other users.

Multimedia Infographics as Journalistic Narratives and the Possibilities of Html5

OpenAIRE

Walter Teixeira Lima Junior; Eduardo Fernando Uliana Barboza

2015-01-01

The article is a comparative study of multimedia infographic elaborated by the Clarín.com (Argentina) and Folha.com, (Brazil) websites. The objective is to verify and analyze how the two important Latin American mediums of online communication have utilized HTML5 technology and its interactive possibilities in journalistic narrating. The analysis will examine multimedia infographics which have gone through substantial technological changes, altering the format and content of news.  In order t...

Building Android Apps with HTML, CSS, and JavaScript

CERN Document Server

Stark, Jonathan

2010-01-01

If you know HTML, CSS, and JavaScript, you already have the tools you need to develop Android applications. This hands-on book shows you how to use these open source web standards to design and build apps that can be adapted for any Android device -- without having to use Java. You'll learn how to create an Android-friendly web app on the platform of your choice, and then convert it to a native Android app with the free PhoneGap framework. Discover why device-agnostic mobile apps are the wave of the future, and start building apps that offer greater flexibility and a broader reach. Learn the

Desarrollo de un sistema de videoconferencia en HTML 5.0

OpenAIRE

Jinoria Fernández, José Alberto

2013-01-01

[ES] Webcam App es una aplicación que tiene como principal objetivo social que las personas puedan realizar videoconferencias a través de la web de forma gratuita y sencilla. Para el desarrollo de la misma, fueron de gran utilidad los elementos que brinda HTML5.0 para dar soporte multimedia: y . También, se usan dos de las APIs que implementa WebRTC para la trasmisión de audio y video en tiempo real, obtenidos desde la webcam: MediaStream (getUserMedia) y RTCPeerConnection. Para soportar est...

Cycle time reduction by Html report in mask checking flow

Science.gov (United States)

Chen, Jian-Cheng; Lu, Min-Ying; Fang, Xiang; Shen, Ming-Feng; Ma, Shou-Yuan; Yang, Chuen-Huei; Tsai, Joe; Lee, Rachel; Deng, Erwin; Lin, Ling-Chieh; Liao, Hung-Yueh; Tsai, Jenny; Bowhill, Amanda; Vu, Hien; Russell, Gordon

2017-07-01

The Mask Data Correctness Check (MDCC) is a reticle-level, multi-layer DRC-like check evolved from mask rule check (MRC). The MDCC uses extended job deck (EJB) to achieve mask composition and to perform a detailed check for positioning and integrity of each component of the reticle. Different design patterns on the mask will be mapped to different layers. Therefore, users may be able to review the whole reticle and check the interactions between different designs before the final mask pattern file is available. However, many types of MDCC check results, such as errors from overlapping patterns usually have very large and complex-shaped highlighted areas covering the boundary of the design. Users have to load the result OASIS file and overlap it to the original database that was assembled in MDCC process on a layout viewer, then search for the details of the check results. We introduce a quick result-reviewing method based on an html format report generated by Calibre® RVE. In the report generation process, we analyze and extract the essential part of result OASIS file to a result database (RDB) file by standard verification rule format (SVRF) commands. Calibre® RVE automatically loads the assembled reticle pattern and generates screen shots of these check results. All the processes are automatically triggered just after the MDCC process finishes. Users just have to open the html report to get the information they need: for example, check summary, captured images of results and their coordinates.

Building Android Apps with HTML, CSS, and JavaScript Making Native Apps with Standards-Based Web Tools

CERN Document Server

Stark, Jonathan

2012-01-01

It's true: if you know HTML, CSS, and JavaScript, you already have the tools you need to develop Android applications. Now updated for HTML5, the second edition of this hands-on guide shows you how to use open source web standards to design and build apps that can be adapted for any Android device. You'll learn how to create an Android-friendly web app on the platform of your choice, and then use Adobe's free PhoneGap framework to convert it to a native Android app. Discover why device-agnostic mobile apps are the wave of the future, and start building apps that offer greater flexibility and

Transforming clinical imaging and 3D data for virtual reality learning objects: HTML5 and mobile devices implementation.

Science.gov (United States)

Trelease, Robert B; Nieder, Gary L

2013-01-01

Web deployable anatomical simulations or "virtual reality learning objects" can easily be produced with QuickTime VR software, but their use for online and mobile learning is being limited by the declining support for web browser plug-ins for personal computers and unavailability on popular mobile devices like Apple iPad and Android tablets. This article describes complementary methods for creating comparable, multiplatform VR learning objects in the new HTML5 standard format, circumventing platform-specific limitations imposed by the QuickTime VR multimedia file format. Multiple types or "dimensions" of anatomical information can be embedded in such learning objects, supporting different kinds of online learning applications, including interactive atlases, examination questions, and complex, multi-structure presentations. Such HTML5 VR learning objects are usable on new mobile devices that do not support QuickTime VR, as well as on personal computers. Furthermore, HTML5 VR learning objects can be embedded in "ebook" document files, supporting the development of new types of electronic textbooks on mobile devices that are increasingly popular and self-adopted for mobile learning. © 2012 American Association of Anatomists.

Building iPhone Apps with HTML, CSS, and JavaScript Making App Store Apps Without Objective-C or Cocoa

CERN Document Server

Stark, Jonathan

2010-01-01

What people are saying about Building iPhone Apps w/ HTML, CSS, and JavaScript "The future of mobile development is clearly web technologies like CSS, HTML and JavaScript. Jonathan Stark shows you how to leverage your existing web development skills to build native iPhone applications using these technologies." --John Allsopp, author and founder of Web Directions "Jonathan's book is the most comprehensive documentation available for developing web applications for mobile Safari. Not just great tech coverage, this book is an easy read of purely fascinating mobile tidbits in a fun colloquial

SurveyWiz and factorWiz: JavaScript Web pages that make HTML forms for research on the Internet.

Science.gov (United States)

Birnbaum, M H

2000-05-01

SurveyWiz and factorWiz are Web pages that act as wizards to create HTML forms that enable one to collect data via the Web. SurveyWiz allows the user to enter survey questions or personality test items with a mixture of text boxes and scales of radio buttons. One can add demographic questions of age, sex, education, and nationality with the push of a button. FactorWiz creates the HTML for within-subjects, two-factor designs as large as 9 x 9, or higher order factorial designs up to 81 cells. The user enters levels of the row and column factors, which can be text, images, or other multimedia. FactorWiz generates the stimulus combinations, randomizes their order, and creates the page. In both programs HTML is displayed in a window, and the user copies it to a text editor to save it. When uploaded to a Web server and supported by a CGI script, the created Web pages allow data to be collected, coded, and saved on the server. These programs are intended to assist researchers and students in quickly creating studies that can be administered via the Web.

A Modular Framework for Transforming Structured Data into HTML with Machine-Readable Annotations

Science.gov (United States)

Patton, E. W.; West, P.; Rozell, E.; Zheng, J.

2010-12-01

There is a plethora of web-based Content Management Systems (CMS) available for maintaining projects and data, i.a. However, each system varies in its capabilities and often content is stored separately and accessed via non-uniform web interfaces. Moving from one CMS to another (e.g., MediaWiki to Drupal) can be cumbersome, especially if a large quantity of data must be adapted to the new system. To standardize the creation, display, management, and sharing of project information, we have assembled a framework that uses existing web technologies to transform data provided by any service that supports the SPARQL Protocol and RDF Query Language (SPARQL) queries into HTML fragments, allowing it to be embedded in any existing website. The framework utilizes a two-tier XML Stylesheet Transformation (XSLT) that uses existing ontologies (e.g., Friend-of-a-Friend, Dublin Core) to interpret query results and render them as HTML documents. These ontologies can be used in conjunction with custom ontologies suited to individual needs (e.g., domain-specific ontologies for describing data records). Furthermore, this transformation process encodes machine-readable annotations, namely, the Resource Description Framework in attributes (RDFa), into the resulting HTML, so that capable parsers and search engines can extract the relationships between entities (e.g, people, organizations, datasets). To facilitate editing of content, the framework provides a web-based form system, mapping each query to a dynamically generated form that can be used to modify and create entities, while keeping the native data store up-to-date. This open framework makes it easy to duplicate data across many different sites, allowing researchers to distribute their data in many different online forums. In this presentation we will outline the structure of queries and the stylesheets used to transform them, followed by a brief walkthrough that follows the data from storage to human- and machine-accessible web

Teaching meta-analysis using MetaLight

Directory of Open Access Journals (Sweden)

Thomas James

2012-10-01

Full Text Available Abstract Background Meta-analysis is a statistical method for combining the results of primary studies. It is often used in systematic reviews and is increasingly a method and topic that appears in student dissertations. MetaLight is a freely available software application that runs simple meta-analyses and contains specific functionality to facilitate the teaching and learning of meta-analysis. While there are many courses and resources for meta-analysis available and numerous software applications to run meta-analyses, there are few pieces of software which are aimed specifically at helping those teaching and learning meta-analysis. Valuable teaching time can be spent learning the mechanics of a new software application, rather than on the principles and practices of meta-analysis. Findings We discuss ways in which the MetaLight tool can be used to present some of the main issues involved in undertaking and interpreting a meta-analysis. Conclusions While there are many software tools available for conducting meta-analysis, in the context of a teaching programme such software can require expenditure both in terms of money and in terms of the time it takes to learn how to use it. MetaLight was developed specifically as a tool to facilitate the teaching and learning of meta-analysis and we have presented here some of the ways it might be used in a training situation.

Modeling the HTML DOM and Browser API in Static Analysis of JavaScript Web Applications

DEFF Research Database (Denmark)

Jensen, Simon Holm; Madsen, Magnus; Møller, Anders

2011-01-01

of reasoning about the flow of control and data in modern JavaScript applications that interact with the HTML DOM and browser API. One application of such a static analysis is to detect type-related and dataflow-related programming errors. We report on experiments with a range of modern web applications...

Development of Science Teaching/Learning Materials Using a New HTML5 Method

OpenAIRE

Yoshidomi, Kenichi

2013-01-01

A new feature is added to HTML5 for rendering graphics for smartphones and tablets without a plug-in. As a result, dynamic content, which has so far been reproduced by using Flash, can be displayed in browser alone. In earth science education, it is necessary to understand that although natural phenomena, including those of cloud and stars, apparently seem not to change in a short time, they change over a long period of time. Also, it is important to understand how they change. If such phenom...

Taking advantage of HTML5 browsers to realize the concepts of session state and workflow sharing in web-tool applications

Science.gov (United States)

Suftin, I.; Read, J. S.; Walker, J.

2013-12-01

Scientists prefer not having to be tied down to a specific machine or operating system in order to analyze local and remote data sets or publish work. Increasingly, analysis has been migrating to decentralized web services and data sets, using web clients to provide the analysis interface. While simplifying workflow access, analysis, and publishing of data, the move does bring with it its own unique set of issues. Web clients used for analysis typically offer workflows geared towards a single user, with steps and results that are often difficult to recreate and share with others. Furthermore, workflow results often may not be easily used as input for further analysis. Older browsers further complicate things by having no way to maintain larger chunks of information, often offloading the job of storage to the back-end server or trying to squeeze it into a cookie. It has been difficult to provide a concept of "session storage" or "workflow sharing" without a complex orchestration of the back-end for storage depending on either a centralized file system or database. With the advent of HTML5, browsers gained the ability to store more information through the use of the Web Storage API (a browser-cookie holds a maximum of 4 kilobytes). Web Storage gives us the ability to store megabytes of arbitrary data in-browser either with an expiration date or just for a session. This allows scientists to create, update, persist and share their workflow without depending on the backend to store session information, providing the flexibility for new web-based workflows to emerge. In the DSASWeb portal ( http://cida.usgs.gov/DSASweb/ ), using these techniques, the representation of every step in the analyst's workflow is stored as plain-text serialized JSON, which we can generate as a text file and provide to the analyst as an upload. This file may then be shared with others and loaded back into the application, restoring the application to the state it was in when the session file

KVK - a Meta Catalog of Libraries

Directory of Open Access Journals (Sweden)

Michael W. Mönnich

2001-07-01

Full Text Available Over the past years, the majority of libraries worldwide implemented interfaces to allow users to access to their bibliographic databases through the WWW. Usually these interfaces consist of HTML-pages with an embedded FORMS template where the search terms are entered. Thus for the first time it was made possible for the user to access almost every library using only one software: the WWW browser. However, if the user has to search more than one library catalog, e.g. when searching literature for a PhD thesis, he has to access a multitude of catalogs deal with different search forms, different search syntaxes, wildcards etc. This is the case especially for users in Germany. Faced with this situation in 1996, our team at the university library of Karlsruhe came up with the idea to create a virtual catalog enabling our library patrons to search several catalogs simultaneously. The idea was inspired by the successful introduction of meta search engines like metacrawler which perform the same function with internet search engines. So why not try to do it with library catalogs? The idea was discussed, and with support from the faculty of computer science, a prototype was built in July 1996. It proved surprisingly easy to do, so we included not only union catalogs but also bookshops. The meta catalog showed so much potential that we decided not to limit access to our local library patrons but to offer it as a service to the internet community as Karlsruher Virtueller Katalog (KVK, Karlsruhe Virtual Catalog. Once the KVK was announced in several mailing list, the usage peaked within a few weeks and has continued to do so.

Tesauros en HTML. Un modelo de diseño y estructura para su consulta en la malla mundial (WWW.

Directory of Open Access Journals (Sweden)

Valle Bracero, Antonio

2000-06-01

Full Text Available A new model is described for outliníng and structuring thesauri for their use as an aid in the database indexing through the World Wide Web (WWW. Several models used in the different on-line help managers were studied and used as main sources on the start up: AcroRead, HTML Help, NetHelp, etc. These on line help systems are used to provide easy access for the users to the operatíon guidelines for several commercial software packages. For this work the guidelines included in the «Microsoft's HTML Help» were used.

The format used for the prototype thesauri in the trials is the native format of the CAT (Confección Automática de Tesauros application developed in CINDOC. From this format and using the methodology outlined in this paper, an HTML file system including search indexes, location indexes and links was developed. This file system allows the user to go to the precise point of the text that refers to the search term. In that point the user will find a number of indications about the relationship between the search term and cither related items. These later ones can be also used as starting points for new searches.

The preliminary trials made with different thesauri, both on-line and on CD-ROM have provided very good results.

Se describe un modelo de diseño y estructura de tesauros para su consulta y utilización en tratamientos de indización de bases de datos a través de la malla mundial (WWW. Como fuentes de estudio de partida se analizaron los modelos empleados en diferentes gestores de documentación de ayuda: AcroRead, HTML Help, NetHelp, etc., utilizados para facilitar, a los usuarios de las diferentes aplicaciones, las normas de uso de las mismas. Para la elaboración del trabajo, se han adoptado las directrices expuestas en «Microsoft's HTML Help».

El formato origen de los tesauros piloto, empleados en las pruebas, ha sido el establecido para la aplicación CAT (Confección Automática de Tesauros

Physics for JavaScript games, animation, and simulations with HTML5 Canvas

CERN Document Server

Dobre, Adrian

2014-01-01

Have you ever wanted to include believable physical behaviors in your games and projects to give them that extra edge? Physics for JavaScript Games, Animation, and Simulations teaches you how to incorporate real physics, such as gravity, friction, and buoyancy, into your HTML5 games, animations, and simulations. It also includes more advanced topics, such as particle systems, which are essential for creating effects such as sparks or smoke. The book also addresses the key issue of balancing accuracy and simplicity in your games and simulations, and the final chapters provide you with the infor

SOA based Data Architecture for HTML5 Web Applications

Directory of Open Access Journals (Sweden)

Catalin STRIMBEI

2013-01-01

Full Text Available Web Services based architectures have already been established as the preferred way to integrate SOA specific components, from the front-end to the back-end business services. One of the key elements of such architecture are data-based or entity services. In this context, SDO standard and SDO related technologies have been confirmed as a possible approach to aggregate such enterprise-wide federation of data services, mainly backed by database servers, but not limited to them. In the followings, we will discuss an architectural purpose based on SDO approach to seamlessly integrate presentation and data services within an enterprise SOA context. This way we will outline the benefits of a common end-to-end data integration strategy. Also, we will try to argue that using HTML5 based clients as front end services in conjunction with SDO data services could be an effective strategy to adopt the mobile computing in the enterprise context.

Beginning iPhone and iPad Web Apps HTML5, CSS3, JavaScript, UI Design, and Mobile Web Standards

CERN Document Server

Apers, Chris

2011-01-01

This book will help you join the thousands of successful iPhone App developers without needing to learn Objective-C or the Cocoa touch APIs. If you want to apply your existing web development skills to iPhone and iPad development, then now you can. WebKit's support for HTML5 means any web developer can create compelling apps for both the iPhone and the larger-screen iPad. Beginning iPhone & iPad Web Apps takes you through the latest mobile web standards as well as the specific features of the iPhone and iPad. You'll learn about WebKit and Mobile Safari, HTML5 and CSS3, vector graphics and mult

The place of SGML and HTML in building electronic patient records.

Science.gov (United States)

Pitty, D; Gordon, C; Reeves, P; Capey, A; Vieyra, P; Rickards, T

1997-01-01

The authors are concerned that, although popular, SGML (Standard Generalized Markup Language) is only one approach to capturing, storing, viewing and exchanging healthcare information and does not provide a suitable paradigm for solving most of the problems associated with paper based patient record systems. Although a discussion of the relative merits of SGML, HTML (HyperText Markup Language) may be interesting, we feel such a discussion is avoiding the real issues associated with the most appropriate way to model, represent, and store electronic patient information in order to solve healthcare problems, and therefore the medical informatics community should firstly concern itself with these issues. The paper substantiates this viewpoint and concludes with some suggestions of how progress can be made.

Dcumento Rechazo MetaBiblioteca

OpenAIRE

prueba1, prueba; Informe actividades realizadas sobre OJS UPTC

2016-01-01

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Next Generation Flight Displays Using HTML5

Science.gov (United States)

Greenwood, Brian

2016-01-01

The Human Integrated Vehicles and Environments (HIVE) lab at Johnson Space Center (JSC) is focused on bringing together inter-disciplinary talent to design and integrate innovative human interface technologies for next generation manned spacecraft. As part of this objective, my summer internship project centered on an ongoing investigation in to building flight displays using the HTML5 standard. Specifically, the goals of my project were to build and demo "flight-like" crew and wearable displays as well as create a webserver for live systems being developed by the Advanced Exploration Systems (AES) program. In parallel to my project, a LabVIEW application, called a display server, was created by the HIVE that uses an XTCE (XML (Extensible Markup Language) Telemetry and Command Exchange) parser and CCSDS (Consultative Committee for Space Data System) space packet decoder to translate telemetry items sent by the CFS (Core Flight Software) over User Datagram Protocol (UDP). It was the webserver's job to receive these UDP messages and send them to the displays. To accomplish this functionality, I utilized Node.js and the accompanying Express framework. On the display side, I was responsible for creating the power system (AMPS) displays. I did this by using HTML5, CSS and JavaScript to create web pages that could update and change dynamically based on the data they received from the webserver. At this point, I have not started on the commanding, being able to send back to the CFS, portion of the displays but hope to have this functionality working by the completion of my internship. I also created a way to test the webserver's functionality without the display server by making a JavaScript application that read in a comma-separate values (CSV) file and converted it to XML which was then sent over UDP. One of the major requirements of my project was to build everything using as little preexisting code as possible, which I accomplished by only using a handful of Java

MCPerm: a Monte Carlo permutation method for accurately correcting the multiple testing in a meta-analysis of genetic association studies.

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Yongshuai Jiang

Full Text Available Traditional permutation (TradPerm tests are usually considered the gold standard for multiple testing corrections. However, they can be difficult to complete for the meta-analyses of genetic association studies based on multiple single nucleotide polymorphism loci as they depend on individual-level genotype and phenotype data to perform random shuffles, which are not easy to obtain. Most meta-analyses have therefore been performed using summary statistics from previously published studies. To carry out a permutation using only genotype counts without changing the size of the TradPerm P-value, we developed a Monte Carlo permutation (MCPerm method. First, for each study included in the meta-analysis, we used a two-step hypergeometric distribution to generate a random number of genotypes in cases and controls. We then carried out a meta-analysis using these random genotype data. Finally, we obtained the corrected permutation P-value of the meta-analysis by repeating the entire process N times. We used five real datasets and five simulation datasets to evaluate the MCPerm method and our results showed the following: (1 MCPerm requires only the summary statistics of the genotype, without the need for individual-level data; (2 Genotype counts generated by our two-step hypergeometric distributions had the same distributions as genotype counts generated by shuffling; (3 MCPerm had almost exactly the same permutation P-values as TradPerm (r = 0.999; P<2.2e-16; (4 The calculation speed of MCPerm is much faster than that of TradPerm. In summary, MCPerm appears to be a viable alternative to TradPerm, and we have developed it as a freely available R package at CRAN: http://cran.r-project.org/web/packages/MCPerm/index.html.

MASCOT HTML and XML parser: an implementation of a novel object model for protein identification data.

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Yang, Chunguang G; Granite, Stephen J; Van Eyk, Jennifer E; Winslow, Raimond L

2006-11-01

Protein identification using MS is an important technique in proteomics as well as a major generator of proteomics data. We have designed the protein identification data object model (PDOM) and developed a parser based on this model to facilitate the analysis and storage of these data. The parser works with HTML or XML files saved or exported from MASCOT MS/MS ions search in peptide summary report or MASCOT PMF search in protein summary report. The program creates PDOM objects, eliminates redundancy in the input file, and has the capability to output any PDOM object to a relational database. This program facilitates additional analysis of MASCOT search results and aids the storage of protein identification information. The implementation is extensible and can serve as a template to develop parsers for other search engines. The parser can be used as a stand-alone application or can be driven by other Java programs. It is currently being used as the front end for a system that loads HTML and XML result files of MASCOT searches into a relational database. The source code is freely available at http://www.ccbm.jhu.edu and the program uses only free and open-source Java libraries.

Meta-Analyst: software for meta-analysis of binary, continuous and diagnostic data

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Schmid Christopher H

2009-12-01

Full Text Available Abstract Background Meta-analysis is increasingly used as a key source of evidence synthesis to inform clinical practice. The theory and statistical foundations of meta-analysis continually evolve, providing solutions to many new and challenging problems. In practice, most meta-analyses are performed in general statistical packages or dedicated meta-analysis programs. Results Herein, we introduce Meta-Analyst, a novel, powerful, intuitive, and free meta-analysis program for the meta-analysis of a variety of problems. Meta-Analyst is implemented in C# atop of the Microsoft .NET framework, and features a graphical user interface. The software performs several meta-analysis and meta-regression models for binary and continuous outcomes, as well as analyses for diagnostic and prognostic test studies in the frequentist and Bayesian frameworks. Moreover, Meta-Analyst includes a flexible tool to edit and customize generated meta-analysis graphs (e.g., forest plots and provides output in many formats (images, Adobe PDF, Microsoft Word-ready RTF. The software architecture employed allows for rapid changes to be made to either the Graphical User Interface (GUI or to the analytic modules. We verified the numerical precision of Meta-Analyst by comparing its output with that from standard meta-analysis routines in Stata over a large database of 11,803 meta-analyses of binary outcome data, and 6,881 meta-analyses of continuous outcome data from the Cochrane Library of Systematic Reviews. Results from analyses of diagnostic and prognostic test studies have been verified in a limited number of meta-analyses versus MetaDisc and MetaTest. Bayesian statistical analyses use the OpenBUGS calculation engine (and are thus as accurate as the standalone OpenBUGS software. Conclusion We have developed and validated a new program for conducting meta-analyses that combines the advantages of existing software for this task.

Evidence-based Neuro Linguistic Psychotherapy: a meta-analysis.

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Zaharia, Cătălin; Reiner, Melita; Schütz, Peter

2015-12-01

Neuro Linguistic Programming (NLP) Framework has enjoyed enormous popularity in the field of applied psychology. NLP has been used in business, education, law, medicine and psychotherapy to identify people's patterns and alter their responses to stimuli, so they are better able to regulate their environment and themselves. NLP looks at achieving goals, creating stable relationships, eliminating barriers such as fears and phobias, building self-confidence, and self-esteem, and achieving peak performance. Neuro Linguistic Psychotherapy (NLPt) encompasses NLP as framework and set of interventions in the treatment of individuals with different psychological and/or social problems. We aimed systematically to analyse the available data regarding the effectiveness of Neuro Linguistic Psychotherapy (NLPt). The present work is a meta-analysis of studies, observational or randomized controlled trials, for evaluating the efficacy of Neuro Linguistic Programming in individuals with different psychological and/or social problems. The databases searched to identify studies in English and German language: CENTRAL in the Cochrane Library; PubMed; ISI Web of Knowledge (include results also from Medline and the Web of Science); PsycINFO (including PsycARTICLES); Psyndex; Deutschsprachige Diplomarbeiten der Psychologie (database of theses in Psychology in German language), Social SciSearch; National library of health and two NLP-specific research databases: one from the NLP Community (http://www.nlp.de/cgi-bin/research/nlprdb.cgi?action=res_entries) and one from the NLP Group (http://www.nlpgrup.com/bilimselarastirmalar/bilimsel-arastirmalar-4.html#Zweig154). From a total number of 425 studies, 350 were removed and considered not relevant based on the title and abstract. Included, in the final analysis, are 12 studies with numbers of participants ranging between 12 and 115 subjects. The vast majority of studies were prospective observational. The actual paper represents the first

ChemCalc: a building block for tomorrow's chemical infrastructure.

Science.gov (United States)

Patiny, Luc; Borel, Alain

2013-05-24

Web services, as an aspect of cloud computing, are becoming an important part of the general IT infrastructure, and scientific computing is no exception to this trend. We propose a simple approach to develop chemical Web services, through which servers could expose the essential data manipulation functionality that students and researchers need for chemical calculations. These services return their results as JSON (JavaScript Object Notation) objects, which facilitates their use for Web applications. The ChemCalc project http://www.chemcalc.org demonstrates this approach: we present three Web services related with mass spectrometry, namely isotopic distribution simulation, peptide fragmentation simulation, and molecular formula determination. We also developed a complete Web application based on these three Web services, taking advantage of modern HTML5 and JavaScript libraries (ChemDoodle and jQuery).

MetaMeta: integrating metagenome analysis tools to improve taxonomic profiling.

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Piro, Vitor C; Matschkowski, Marcel; Renard, Bernhard Y

2017-08-14

Many metagenome analysis tools are presently available to classify sequences and profile environmental samples. In particular, taxonomic profiling and binning methods are commonly used for such tasks. Tools available among these two categories make use of several techniques, e.g., read mapping, k-mer alignment, and composition analysis. Variations on the construction of the corresponding reference sequence databases are also common. In addition, different tools provide good results in different datasets and configurations. All this variation creates a complicated scenario to researchers to decide which methods to use. Installation, configuration and execution can also be difficult especially when dealing with multiple datasets and tools. We propose MetaMeta: a pipeline to execute and integrate results from metagenome analysis tools. MetaMeta provides an easy workflow to run multiple tools with multiple samples, producing a single enhanced output profile for each sample. MetaMeta includes a database generation, pre-processing, execution, and integration steps, allowing easy execution and parallelization. The integration relies on the co-occurrence of organisms from different methods as the main feature to improve community profiling while accounting for differences in their databases. In a controlled case with simulated and real data, we show that the integrated profiles of MetaMeta overcome the best single profile. Using the same input data, it provides more sensitive and reliable results with the presence of each organism being supported by several methods. MetaMeta uses Snakemake and has six pre-configured tools, all available at BioConda channel for easy installation (conda install -c bioconda metameta). The MetaMeta pipeline is open-source and can be downloaded at: https://gitlab.com/rki_bioinformatics .

Multimedia Infographics as Journalistic Narratives and the Possibilities of Html5

Directory of Open Access Journals (Sweden)

Walter Teixeira Lima Junior

2015-12-01

Full Text Available The article is a comparative study of multimedia infographic elaborated by the Clarín.com (Argentina and Folha.com, (Brazil websites. The objective is to verify and analyze how the two important Latin American mediums of online communication have utilized HTML5 technology and its interactive possibilities in journalistic narrating. The analysis will examine multimedia infographics which have gone through substantial technological changes, altering the format and content of news.  In order to understand the narrative possibilities of Flash and HTLM5 technologies for the production of interactive infographics this study will deal with the infographics section related to Folha.com and Especiales Multimedia from Clarin.com.  The study, both quantitative and qualitative, verified which narrative and informative resources, tools and Internet programming language technologies were utilized by the two mediums of communication based on the analysis model proposed by Albert Cairo in the book Infografia 2.0.

HTML 5 Displays for On-Board Flight Systems

Science.gov (United States)

Silva, Chandika

2016-01-01

During my Internship at NASA in the summer of 2016, I was assigned to a project which dealt with developing a web-server that would display telemetry and other system data using HTML 5, JavaScript, and CSS. By doing this, it would be possible to view the data across a variety of screen sizes, and establish a standard that could be used to simplify communication and software development between NASA and other countries. Utilizing a web- approach allowed us to add in more functionality, as well as make the displays more aesthetically pleasing for the users. When I was assigned to this project my main task was to first establish communication with the current display server. This display server would output data from the on-board systems in XML format. Once communication was established I was then asked to create a dynamic telemetry table web page that would update its header and change as new information came in. After this was completed, certain minor functionalities were added to the table such as a hide column and filter by system option. This was more for the purpose of making the table more useful for the users, as they can now filter and view relevant data. Finally my last task was to create a graphical system display for all the systems on the space craft. This was by far the most challenging part of my internship as finding a JavaScript library that was both free and contained useful functions to assist me in my task was difficult. In the end I was able to use the JointJs library and accomplish the task. With the help of my mentor and the HIVE lab team, we were able to establish stable communication with the display server. We also succeeded in creating a fully dynamic telemetry table and in developing a graphical system display for the advanced modular power system. Working in JSC for this internship has taught me a lot about coding in JavaScript and HTML 5. I was also introduced to the concept of developing software as a team, and exposed to the different

Pengembangan Aplikasi Game dengan Html5 dan Javascript untuk Mengukur Kecerdasan Anak

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Muhammad Ismail

2014-12-01

Full Text Available Educational games are the ideal medium to see the extent to which a student's performance will be assessed. However, to integrate educational games has the technical and practical challenges of their own. This study will be directed to the development of a game that can be used to measure the kind of intelligence and capabilities of a child based on the reference of Psychology Howard Gardner's theory kuisinoerThe purpose of writing is the development of gaming applications with HTML5 and JavaScript enabled to measure intelligence. The data taken from the distribution of questionnaires to 30 respondents were randomly. The data were analyzed by finding the average difference between the results of tests using questionnaires to play the game. From these results it can be concluded that there is a gap/difference between the average differences among the results of the two tests.

Meta-DiSc: a software for meta-analysis of test accuracy data.

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Zamora, Javier; Abraira, Victor; Muriel, Alfonso; Khan, Khalid; Coomarasamy, Arri

2006-07-12

Systematic reviews and meta-analyses of test accuracy studies are increasingly being recognised as central in guiding clinical practice. However, there is currently no dedicated and comprehensive software for meta-analysis of diagnostic data. In this article, we present Meta-DiSc, a Windows-based, user-friendly, freely available (for academic use) software that we have developed, piloted, and validated to perform diagnostic meta-analysis. Meta-DiSc a) allows exploration of heterogeneity, with a variety of statistics including chi-square, I-squared and Spearman correlation tests, b) implements meta-regression techniques to explore the relationships between study characteristics and accuracy estimates, c) performs statistical pooling of sensitivities, specificities, likelihood ratios and diagnostic odds ratios using fixed and random effects models, both overall and in subgroups and d) produces high quality figures, including forest plots and summary receiver operating characteristic curves that can be exported for use in manuscripts for publication. All computational algorithms have been validated through comparison with different statistical tools and published meta-analyses. Meta-DiSc has a Graphical User Interface with roll-down menus, dialog boxes, and online help facilities. Meta-DiSc is a comprehensive and dedicated test accuracy meta-analysis software. It has already been used and cited in several meta-analyses published in high-ranking journals. The software is publicly available at http://www.hrc.es/investigacion/metadisc_en.htm.

MetaGenyo: a web tool for meta-analysis of genetic association studies.

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Martorell-Marugan, Jordi; Toro-Dominguez, Daniel; Alarcon-Riquelme, Marta E; Carmona-Saez, Pedro

2017-12-16

Genetic association studies (GAS) aims to evaluate the association between genetic variants and phenotypes. In the last few years, the number of this type of study has increased exponentially, but the results are not always reproducible due to experimental designs, low sample sizes and other methodological errors. In this field, meta-analysis techniques are becoming very popular tools to combine results across studies to increase statistical power and to resolve discrepancies in genetic association studies. A meta-analysis summarizes research findings, increases statistical power and enables the identification of genuine associations between genotypes and phenotypes. Meta-analysis techniques are increasingly used in GAS, but it is also increasing the amount of published meta-analysis containing different errors. Although there are several software packages that implement meta-analysis, none of them are specifically designed for genetic association studies and in most cases their use requires advanced programming or scripting expertise. We have developed MetaGenyo, a web tool for meta-analysis in GAS. MetaGenyo implements a complete and comprehensive workflow that can be executed in an easy-to-use environment without programming knowledge. MetaGenyo has been developed to guide users through the main steps of a GAS meta-analysis, covering Hardy-Weinberg test, statistical association for different genetic models, analysis of heterogeneity, testing for publication bias, subgroup analysis and robustness testing of the results. MetaGenyo is a useful tool to conduct comprehensive genetic association meta-analysis. The application is freely available at http://bioinfo.genyo.es/metagenyo/ .

Presentation and response timing accuracy in Adobe Flash and HTML5/JavaScript Web experiments.

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Reimers, Stian; Stewart, Neil

2015-06-01

Web-based research is becoming ubiquitous in the behavioral sciences, facilitated by convenient, readily available participant pools and relatively straightforward ways of running experiments: most recently, through the development of the HTML5 standard. Although in most studies participants give untimed responses, there is a growing interest in being able to record response times online. Existing data on the accuracy and cross-machine variability of online timing measures are limited, and generally they have compared behavioral data gathered on the Web with similar data gathered in the lab. For this article, we took a more direct approach, examining two ways of running experiments online-Adobe Flash and HTML5 with CSS3 and JavaScript-across 19 different computer systems. We used specialist hardware to measure stimulus display durations and to generate precise response times to visual stimuli in order to assess measurement accuracy, examining effects of duration, browser, and system-to-system variability (such as across different Windows versions), as well as effects of processing power and graphics capability. We found that (a) Flash and JavaScript's presentation and response time measurement accuracy are similar; (b) within-system variability is generally small, even in low-powered machines under high load; (c) the variability of measured response times across systems is somewhat larger; and (d) browser type and system hardware appear to have relatively small effects on measured response times. Modeling of the effects of this technical variability suggests that for most within- and between-subjects experiments, Flash and JavaScript can both be used to accurately detect differences in response times across conditions. Concerns are, however, noted about using some correlational or longitudinal designs online.

Meta-analysis with R

CERN Document Server

Schwarzer, Guido; Rücker, Gerta

2015-01-01

This book provides a comprehensive introduction to performing meta-analysis using the statistical software R. It is intended for quantitative researchers and students in the medical and social sciences who wish to learn how to perform meta-analysis with R. As such, the book introduces the key concepts and models used in meta-analysis. It also includes chapters on the following advanced topics: publication bias and small study effects; missing data; multivariate meta-analysis, network meta-analysis; and meta-analysis of diagnostic studies.  .

Building a semi-automatic ontology learning and construction system for geosciences

Science.gov (United States)

Babaie, H. A.; Sunderraman, R.; Zhu, Y.

2013-12-01

just HTML5 and Javascript, thereby avoiding cumbersome server side coding present in the traditional approaches. The JSON format used in MongoDB is also suitable for storing and querying RDF data. We will store the domain ontologies and associated linked data in JSON/RDF formats. Our Web interface will be built upon the open source and configurable WebProtege ontology editor. We will develop a simplified mobile version of our user interface which will automatically detect the hosting device and adjust the user interface layout to accommodate different screen sizes. We will also use the Semantic Media Wiki that allows the user to store and query the data within the wiki pages. By using HTML 5, JavaScript, and WebGL, we aim to create an interactive, dynamic, and multi-dimensional user interface that presents various geosciences data sets in a natural and intuitive way.

Options for a health system researcher to choose in Meta Review (MR approaches-Meta Narrative (MN and Meta Triangulation (MT

Directory of Open Access Journals (Sweden)

Sanjeev Davey

2015-01-01

Full Text Available Two new approaches in systematic reviewing i.e. Meta-narrative review(MNR (which a health researcher can use for topics which are differently conceptualized and studied by different types of researchers for policy decisions and Meta-triangulation review(MTR (done to build theory for studying multifaceted phenomena characterized by expansive and contested research domains are ready for penetration in an arena of health system research. So critical look at which approach in Meta-review is better i.e. Meta-narrative review or Meta-triangulation review, can give new insights to a health system researcher. A systematic review on 2 key words-"meta-narrative review" and "meta-triangulation review" in health system research, were searched from key search engines, such as Pubmed, Cochrane library, Bio-med Central and Google Scholar etc till 21st March 2014 since last 20 years. Studies from both developed and developing world were included in any form and scope to draw final conclusions. However unpublished data from thesis was not included in systematic review. Meta-narrative review is a type of systematic review which can be used for a wide range of topics and questions involving making judgments and inferences in public health. On the other hand Meta-triangulation review is a three-phased, qualitative meta-analysis process which can be used to explore variations in the assumptions of alternative paradigms, gain insights into these multiple paradigms at one point of time and addresses emerging themes and the resulting theories.

MetaComp: comprehensive analysis software for comparative meta-omics including comparative metagenomics.

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Zhai, Peng; Yang, Longshu; Guo, Xiao; Wang, Zhe; Guo, Jiangtao; Wang, Xiaoqi; Zhu, Huaiqiu

2017-10-02

During the past decade, the development of high throughput nucleic sequencing and mass spectrometry analysis techniques have enabled the characterization of microbial communities through metagenomics, metatranscriptomics, metaproteomics and metabolomics data. To reveal the diversity of microbial communities and interactions between living conditions and microbes, it is necessary to introduce comparative analysis based upon integration of all four types of data mentioned above. Comparative meta-omics, especially comparative metageomics, has been established as a routine process to highlight the significant differences in taxon composition and functional gene abundance among microbiota samples. Meanwhile, biologists are increasingly concerning about the correlations between meta-omics features and environmental factors, which may further decipher the adaptation strategy of a microbial community. We developed a graphical comprehensive analysis software named MetaComp comprising a series of statistical analysis approaches with visualized results for metagenomics and other meta-omics data comparison. This software is capable to read files generated by a variety of upstream programs. After data loading, analyses such as multivariate statistics, hypothesis testing of two-sample, multi-sample as well as two-group sample and a novel function-regression analysis of environmental factors are offered. Here, regression analysis regards meta-omic features as independent variable and environmental factors as dependent variables. Moreover, MetaComp is capable to automatically choose an appropriate two-group sample test based upon the traits of input abundance profiles. We further evaluate the performance of its choice, and exhibit applications for metagenomics, metaproteomics and metabolomics samples. MetaComp, an integrative software capable for applying to all meta-omics data, originally distills the influence of living environment on microbial community by regression analysis

MetaMetaDB: a database and analytic system for investigating microbial habitability.

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Ching-chia Yang

Full Text Available MetaMetaDB (http://mmdb.aori.u-tokyo.ac.jp/ is a database and analytic system for investigating microbial habitability, i.e., how a prokaryotic group can inhabit different environments. The interaction between prokaryotes and the environment is a key issue in microbiology because distinct prokaryotic communities maintain distinct ecosystems. Because 16S ribosomal RNA (rRNA sequences play pivotal roles in identifying prokaryotic species, a system that comprehensively links diverse environments to 16S rRNA sequences of the inhabitant prokaryotes is necessary for the systematic understanding of the microbial habitability. However, existing databases are biased to culturable prokaryotes and exhibit limitations in the comprehensiveness of the data because most prokaryotes are unculturable. Recently, metagenomic and 16S rRNA amplicon sequencing approaches have generated abundant 16S rRNA sequence data that encompass unculturable prokaryotes across diverse environments; however, these data are usually buried in large databases and are difficult to access. In this study, we developed MetaMetaDB (Meta-Metagenomic DataBase, which comprehensively and compactly covers 16S rRNA sequences retrieved from public datasets. Using MetaMetaDB, users can quickly generate hypotheses regarding the types of environments a prokaryotic group may be adapted to. We anticipate that MetaMetaDB will improve our understanding of the diversity and evolution of prokaryotes.

MetaMetaDB: a database and analytic system for investigating microbial habitability.

Science.gov (United States)

Yang, Ching-chia; Iwasaki, Wataru

2014-01-01

MetaMetaDB (http://mmdb.aori.u-tokyo.ac.jp/) is a database and analytic system for investigating microbial habitability, i.e., how a prokaryotic group can inhabit different environments. The interaction between prokaryotes and the environment is a key issue in microbiology because distinct prokaryotic communities maintain distinct ecosystems. Because 16S ribosomal RNA (rRNA) sequences play pivotal roles in identifying prokaryotic species, a system that comprehensively links diverse environments to 16S rRNA sequences of the inhabitant prokaryotes is necessary for the systematic understanding of the microbial habitability. However, existing databases are biased to culturable prokaryotes and exhibit limitations in the comprehensiveness of the data because most prokaryotes are unculturable. Recently, metagenomic and 16S rRNA amplicon sequencing approaches have generated abundant 16S rRNA sequence data that encompass unculturable prokaryotes across diverse environments; however, these data are usually buried in large databases and are difficult to access. In this study, we developed MetaMetaDB (Meta-Metagenomic DataBase), which comprehensively and compactly covers 16S rRNA sequences retrieved from public datasets. Using MetaMetaDB, users can quickly generate hypotheses regarding the types of environments a prokaryotic group may be adapted to. We anticipate that MetaMetaDB will improve our understanding of the diversity and evolution of prokaryotes.

Introduction, comparison, and validation of Meta-Essentials: A free and simple tool for meta-analysis.

Science.gov (United States)

Suurmond, Robert; van Rhee, Henk; Hak, Tony

2017-12-01

We present a new tool for meta-analysis, Meta-Essentials, which is free of charge and easy to use. In this paper, we introduce the tool and compare its features to other tools for meta-analysis. We also provide detailed information on the validation of the tool. Although free of charge and simple, Meta-Essentials automatically calculates effect sizes from a wide range of statistics and can be used for a wide range of meta-analysis applications, including subgroup analysis, moderator analysis, and publication bias analyses. The confidence interval of the overall effect is automatically based on the Knapp-Hartung adjustment of the DerSimonian-Laird estimator. However, more advanced meta-analysis methods such as meta-analytical structural equation modelling and meta-regression with multiple covariates are not available. In summary, Meta-Essentials may prove a valuable resource for meta-analysts, including researchers, teachers, and students. © 2017 The Authors. Research Synthesis Methods published by John Wiley & Sons Ltd.

Meta-research matters: Meta-spin cycles, the blindness of bias, and rebuilding trust.

Science.gov (United States)

Bero, Lisa

2018-04-01

Meta-research is research about research. Meta-research may not be as click-worthy as a meta-pug-a pug dog dressed up in a pug costume-but it is crucial to understanding research. A particularly valuable contribution of meta-research is to identify biases in a body of evidence. Bias can occur in the design, conduct, or publication of research and is a systematic deviation from the truth in results or inferences. The findings of meta-research can tell us which evidence to trust and what must be done to improve future research. We should be using meta-research to provide the evidence base for implementing systemic changes to improve research, not for discrediting it.

Data Conversion Tool For Tobii Pro Glasses 2 Live Data Files

DEFF Research Database (Denmark)

Wulff-Jensen, Andreas

2017-01-01

The data gathered through the Tobii Pro Glasses 2 is saved in a .json file called livedata.json. This format is convenient for the Tobii analysis software, but for any other analysis software packages it can be rather troublesome as the software packages do not know how to interpret the .json file...

From MetaCognition to MetaPractition

DEFF Research Database (Denmark)

Alcock, Gordon Lindsay

developed frameworks for both quantitative and qualitative Metacognitive and ‘Meta-practitive’ reflection.. Designed to help students adapt to, and adopt new learning strategies; accelerate their understanding and performance within a collaborative ‘Profession Bachelor’ and PBL culture, the author documents...... ‘Metacognitive’ learning portfolios in the initial ‘Learning to Learn (L2L) environment and a self-authoring, ‘Meta-practitive’ approach in the later stages of an ‘Architectural Technology degree....

Network Visualization Project (NVP)

Science.gov (United States)

2016-07-01

Application data flow .............................................................................2 Fig. 2 Sample JSON data...interface supporting improved network analysis and network communication visualization. 2. Application Design NVP consists of 2 parts: back-end data...notation ( JSON ) format. This JSON is provided as input to the front-end application of the project. This interaction of the user with the back-end

META-NORD

DEFF Research Database (Denmark)

Vasilejev, Andrejs; Pedersen, Bolette Sandford; De Smeth, Koenraad

2011-01-01

This position paper presents META-NORD project which develops Nordic and Baltic part of the European open language resource infrastructure. META-NORD works on assembling, linking across languages, and making widely available the basic language resources used by developers, professionals...

Making It Work for Everyone: HTML5 and CSS Level 3 for Responsive, Accessible Design on Your Library's Web Site

Science.gov (United States)

Baker, Stewart C.

2014-01-01

This article argues that accessibility and universality are essential to good Web design. A brief review of library science literature sets the issue of Web accessibility in context. The bulk of the article explains the design philosophies of progressive enhancement and responsive Web design, and summarizes recent updates to WCAG 2.0, HTML5, CSS…

Education Game of Multiplying Based on Horizontal Method of HTML 5 and Android

Directory of Open Access Journals (Sweden)

Michael Yoseph Ricky

2015-09-01

Full Text Available Over the years, technology is growing rapidly followed by the development of game and its variations. Now, game is easily found on a mobile device. Moreover, game on mobile device can also be used as an excellent medium for learning or often referred as educational game because the nature of educational game is practical, easy to carry anywhere, and tends to be fun. This research was to create a mobile game application for learning with Horizontal method based on HTML 5 and Phonegap and to introduce the method as a method of mathematical multiplication process. This research used the Scrum method for program development. The results obtained showed that the game in this study is considered attractive and received a positive response from the player. Player also found it helpful to know the patterns of mathematics through the multiplication ofnumbers in this game. So through this game the player can perform mathematical multiplication calculations quickly.

Developing a Tile-Based Rendering Method to Improve Rendering Speed of 3D Geospatial Data with HTML5 and WebGL

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Seokchan Kang

2017-01-01

Full Text Available A dedicated plug-in has been installed to visualize three-dimensional (3D city modeling spatial data in web-based applications. However, plug-in methods are gradually becoming obsolete, owing to their limited performance with respect to installation errors, unsupported cross-browsers, and security vulnerability. Particularly, in 2015, the NPAPI service was terminated in most existing web browsers except Internet Explorer. To overcome these problems, the HTML5/WebGL (next-generation web standard, confirmed in October 2014 technology emerged. In particular, WebGL is able to display 3D spatial data without plug-ins in browsers. In this study, we attempted to identify the requirements and limitations of displaying 3D city modeling spatial data using HTML5/WebGL, and we propose alternative ways based on the bin-packing algorithm that aggregates individual 3D city modeling data including buildings in tile units. The proposed method reduces the operational complexity and the number and volume of transmissions required for rendering processing to improve the speed of 3D data rendering. The proposed method was validated on real data for evaluating its effectiveness in 3D visualization of city modeling data in web-based applications.

Workflows in bioinformatics: meta-analysis and prototype implementation of a workflow generator

Directory of Open Access Journals (Sweden)

Thoraval Samuel

2005-04-01

Full Text Available Abstract Background Computational methods for problem solving need to interleave information access and algorithm execution in a problem-specific workflow. The structures of these workflows are defined by a scaffold of syntactic, semantic and algebraic objects capable of representing them. Despite the proliferation of GUIs (Graphic User Interfaces in bioinformatics, only some of them provide workflow capabilities; surprisingly, no meta-analysis of workflow operators and components in bioinformatics has been reported. Results We present a set of syntactic components and algebraic operators capable of representing analytical workflows in bioinformatics. Iteration, recursion, the use of conditional statements, and management of suspend/resume tasks have traditionally been implemented on an ad hoc basis and hard-coded; by having these operators properly defined it is possible to use and parameterize them as generic re-usable components. To illustrate how these operations can be orchestrated, we present GPIPE, a prototype graphic pipeline generator for PISE that allows the definition of a pipeline, parameterization of its component methods, and storage of metadata in XML formats. This implementation goes beyond the macro capacities currently in PISE. As the entire analysis protocol is defined in XML, a complete bioinformatic experiment (linked sets of methods, parameters and results can be reproduced or shared among users. Availability: http://if-web1.imb.uq.edu.au/Pise/5.a/gpipe.html (interactive, ftp://ftp.pasteur.fr/pub/GenSoft/unix/misc/Pise/ (download. Conclusion From our meta-analysis we have identified syntactic structures and algebraic operators common to many workflows in bioinformatics. The workflow components and algebraic operators can be assimilated into re-usable software components. GPIPE, a prototype implementation of this framework, provides a GUI builder to facilitate the generation of workflows and integration of heterogeneous

Meta-STEPP: subpopulation treatment effect pattern plot for individual patient data meta-analysis.

Science.gov (United States)

Wang, Xin Victoria; Cole, Bernard; Bonetti, Marco; Gelber, Richard D

2016-09-20

We have developed a method, called Meta-STEPP (subpopulation treatment effect pattern plot for meta-analysis), to explore treatment effect heterogeneity across covariate values in the meta-analysis setting for time-to-event data when the covariate of interest is continuous. Meta-STEPP forms overlapping subpopulations from individual patient data containing similar numbers of events with increasing covariate values, estimates subpopulation treatment effects using standard fixed-effects meta-analysis methodology, displays the estimated subpopulation treatment effect as a function of the covariate values, and provides a statistical test to detect possibly complex treatment-covariate interactions. Simulation studies show that this test has adequate type-I error rate recovery as well as power when reasonable window sizes are chosen. When applied to eight breast cancer trials, Meta-STEPP suggests that chemotherapy is less effective for tumors with high estrogen receptor expression compared with those with low expression. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

A new record editor for Invenio 3

CERN Multimedia

CERN. Geneva

2017-01-01

On this presentation, a new record editor will be presented. Current version under development can be found in https://github.com/inveniosoftware-contrib/ng2-json-editor. This editor uses JSON as its native data format, provides many configuration options and can handle very large JSON documents. An update on the development status and pointers to how to use it in your own installation will be provided.

MetaEasy: A Meta-Analysis Add-In for Microsoft Excel

Directory of Open Access Journals (Sweden)

Evangelos Kontopantelis

2009-04-01

Full Text Available Meta-analysis is a statistical methodology that combines or integrates the results ofseveral independent clinical trials considered by the analyst to be `combinable' (Huque1988. However, completeness and user-friendliness are uncommon both in specialisedmeta-analysis software packages and in mainstream statistical packages that have to relyon user-written commands. We implemented the meta-analysis methodology in an Mi-crosoft Excel add-in which is freely available and incorporates more meta-analysis models(including the iterative maximum likelihood and prole likelihood than are usually avail-able, while paying particular attention to the user-friendliness of the package.

Locating and parsing bibliographic references in HTML medical articles.

Science.gov (United States)

Zou, Jie; Le, Daniel; Thoma, George R

2010-06-01

The set of references that typically appear toward the end of journal articles is sometimes, though not always, a field in bibliographic (citation) databases. But even if references do not constitute such a field, they can be useful as a preprocessing step in the automated extraction of other bibliographic data from articles, as well as in computer-assisted indexing of articles. Automation in data extraction and indexing to minimize human labor is key to the affordable creation and maintenance of large bibliographic databases. Extracting the components of references, such as author names, article title, journal name, publication date and other entities, is therefore a valuable and sometimes necessary task. This paper describes a two-step process using statistical machine learning algorithms, to first locate the references in HTML medical articles and then to parse them. Reference locating identifies the reference section in an article and then decomposes it into individual references. We formulate this step as a two-class classification problem based on text and geometric features. An evaluation conducted on 500 articles drawn from 100 medical journals achieves near-perfect precision and recall rates for locating references. Reference parsing identifies the components of each reference. For this second step, we implement and compare two algorithms. One relies on sequence statistics and trains a Conditional Random Field. The other focuses on local feature statistics and trains a Support Vector Machine to classify each individual word, followed by a search algorithm that systematically corrects low confidence labels if the label sequence violates a set of predefined rules. The overall performance of these two reference-parsing algorithms is about the same: above 99% accuracy at the word level, and over 97% accuracy at the chunk level.

Living network meta-analysis compared with pairwise meta-analysis in comparative effectiveness research: empirical study

Science.gov (United States)

Nikolakopoulou, Adriani; Mavridis, Dimitris; Furukawa, Toshi A; Cipriani, Andrea; Tricco, Andrea C; Straus, Sharon E; Siontis, George C M; Egger, Matthias

2018-01-01

Abstract Objective To examine whether the continuous updating of networks of prospectively planned randomised controlled trials (RCTs) (“living” network meta-analysis) provides strong evidence against the null hypothesis in comparative effectiveness of medical interventions earlier than the updating of conventional, pairwise meta-analysis. Design Empirical study of the accumulating evidence about the comparative effectiveness of clinical interventions. Data sources Database of network meta-analyses of RCTs identified through searches of Medline, Embase, and the Cochrane Database of Systematic Reviews until 14 April 2015. Eligibility criteria for study selection Network meta-analyses published after January 2012 that compared at least five treatments and included at least 20 RCTs. Clinical experts were asked to identify in each network the treatment comparison of greatest clinical interest. Comparisons were excluded for which direct and indirect evidence disagreed, based on side, or node, splitting test (Pmeta-analysis. The frequency and time to strong evidence was compared against the null hypothesis between pairwise and network meta-analyses. Results 49 comparisons of interest from 44 networks were included; most (n=39, 80%) were between active drugs, mainly from the specialties of cardiology, endocrinology, psychiatry, and rheumatology. 29 comparisons were informed by both direct and indirect evidence (59%), 13 by indirect evidence (27%), and 7 by direct evidence (14%). Both network and pairwise meta-analysis provided strong evidence against the null hypothesis for seven comparisons, but for an additional 10 comparisons only network meta-analysis provided strong evidence against the null hypothesis (P=0.002). The median time to strong evidence against the null hypothesis was 19 years with living network meta-analysis and 23 years with living pairwise meta-analysis (hazard ratio 2.78, 95% confidence interval 1.00 to 7.72, P=0.05). Studies directly comparing

BUMS--Bonner sphere Unfolding Made Simple an HTML based multisphere neutron spectrometer unfolding package

CERN Document Server

Sweezy, J; Veinot, K

2002-01-01

A new multisphere neutron spectrometer unfolding package, Bonner sphere Unfolding Made Simple (BUMS) has been developed that uses an HTML interface to simplify data input and code execution for the novice and the advanced user. This new unfolding package combines the unfolding algorithms contained in other popular unfolding codes under one easy to use interface. The interface makes use of web browsing software to provide a graphical user interface to the unfolding algorithms. BUMS integrates the SPUNIT, BON, MAXIET, and SAND-II unfolding algorithms into a single package. This package also includes a library of 14 response matrices, 58 starting spectra, and 24 dose and detector responses. BUMS has several improvements beyond the addition of unfolding algorithms. It has the ability to search for the most appropriate starting spectra. Also, plots of the unfolded neutron spectra are automatically generated. The BUMS package runs via a web server and may be accessed by any computer with access to the Internet at h...

BUMS--Bonner sphere Unfolding Made Simple: an HTML based multisphere neutron spectrometer unfolding package

International Nuclear Information System (INIS)

Sweezy, Jeremy; Hertel, Nolan; Veinot, Ken

2002-01-01

A new multisphere neutron spectrometer unfolding package, Bonner sphere Unfolding Made Simple (BUMS) has been developed that uses an HTML interface to simplify data input and code execution for the novice and the advanced user. This new unfolding package combines the unfolding algorithms contained in other popular unfolding codes under one easy to use interface. The interface makes use of web browsing software to provide a graphical user interface to the unfolding algorithms. BUMS integrates the SPUNIT, BON, MAXIET, and SAND-II unfolding algorithms into a single package. This package also includes a library of 14 response matrices, 58 starting spectra, and 24 dose and detector responses. BUMS has several improvements beyond the addition of unfolding algorithms. It has the ability to search for the most appropriate starting spectra. Also, plots of the unfolded neutron spectra are automatically generated. The BUMS package runs via a web server and may be accessed by any computer with access to the Internet at http://nukeisit.gatech.edu/bums

A browser-based event display for the CMS experiment at the LHC

International Nuclear Information System (INIS)

Hategan, M; McCauley, T; Nguyen, P

2012-01-01

The line between native and web applications is becoming increasingly blurred as modern web browsers are becoming powerful platforms on which applications can be run. Such applications are trivial to install and are readily extensible and easy to use. In an educational setting, web applications permit a way to deploy deploy tools in a highly-restrictive computing environment. The I2U2 collaboration has developed a browser-based event display for viewing events in data collected and released to the public by the CMS experiment at the LHC. The application itself reads a JSON event format and uses the JavaScript 3D rendering engine pre3d. The only requirement is a modern browser using HTML5 canvas. The event display has been used by thousands of high school students in the context of programs organized by I2U2, QuarkNet, and IPPOG. This browser-based approach to display of events can have broader usage and impact for experts and public alike.

An object-oriented approach to deploying highly configurable web interfaces for the ATLAS experiment

CERN Document Server

Lange Ramos, Bruno; The ATLAS collaboration; Pommes, Kathy; Pavani Neto, Varlen; Vieira Arosa, Breno

2015-01-01

In order to manage a heterogeneous and worldwide collaboration, the ATLAS experiment develops web systems that range from supporting the process of publishing scientific papers to monitoring equipment radiation levels. These systems are vastly supported by Glance, a technology that was set forward in 2004 to create an abstraction layer on top of varied databases that automatically recognizes their modeling and generate web search interfaces. Fence (Front ENd ENgine for glaNCE) assembles classes to build applications by making extensive use of configuration files. It produces templates of the core JSON files on top of which it is possible to create Glance-compliant search interfaces. Once the database, its schemas and tables are defined using Glance, its records can be incorporated into the templates by escaping the returned values with a reference to the column identifier wrapped around double enclosing brackets. The developer may also expand on available configuration files to create HTML forms and securely ...

La ilegalidad, los meta-ordenamientos y las meta-preferencias

Directory of Open Access Journals (Sweden)

González , Jorge Iván

2000-06-01

Full Text Available Este artículo tiene como punto de partida los trabajos de Sen sobre meta-ordenamientos y meta-preferencias y busca explicar la ilegalidad como un problema de racionalidad. Después de mostrar el alcance de estas meta-categorías el trabajo desnuda algunas limitaciones de la aproximación costo-beneficio al análisis de la ilegalidad. Más adelante sugiere el concepto de las meta-preferencias, que explora la manera como las creencias y los deseos contribuyen a la formación de las preferencias, ayuda a entender el espacio borroso que existe entre lo legal, lo ilegal, lo legítimo y lo ilegítimo. Según el autor, hace falta reflexionar más sobre la naturaleza de las creencias y deseos que llevan a moldear las preferencias de los individuos y las sociedades, para no caer en explicaciones simplistas de la ilegalidad basadas en criterios arbitrarios de lo bueno. También concluye que la presencia de metapreferencias inconsistentes puede explicar por qué mayores gastos en seguridad y justicia no han resultado en una reducción de la impunidad.

GSA CIO Governance Board Membership List

Data.gov (United States)

General Services Administration — Each agency is expected to post a JSON file for their Bureau IT Leadership Directory to the following URL path: [agency.gov]/digitalstrategy/governanceboards.json....

Perancangan dan Pembuatan Game Online “Penyelamatan Tawanan Perang” Berbasis Html 5 untuk Penerapan Aplikasi Game Facebook Menggunakan Engine Construct 2

OpenAIRE

Asrori, Lutfi; Luthfi, Emha Taufiq

2012-01-01

Gaming technology is one of the highlights of the developer in the virtual world. Recently emerging flash based game called Angry Bird, this game successfully anesthetize the game lovers ranging from children to adults. Then in 2012 also developed the software to create a game with HTML5 base.But unfortunately most outstanding online games and famous people today are made overseas and leading manufacturer classmates agate, artificial personal who want to explore the latest science is still ve...

Meta-connectomics: human brain network and connectivity meta-analyses.

Science.gov (United States)

Crossley, N A; Fox, P T; Bullmore, E T

2016-04-01

Abnormal brain connectivity or network dysfunction has been suggested as a paradigm to understand several psychiatric disorders. We here review the use of novel meta-analytic approaches in neuroscience that go beyond a summary description of existing results by applying network analysis methods to previously published studies and/or publicly accessible databases. We define this strategy of combining connectivity with other brain characteristics as 'meta-connectomics'. For example, we show how network analysis of task-based neuroimaging studies has been used to infer functional co-activation from primary data on regional activations. This approach has been able to relate cognition to functional network topology, demonstrating that the brain is composed of cognitively specialized functional subnetworks or modules, linked by a rich club of cognitively generalized regions that mediate many inter-modular connections. Another major application of meta-connectomics has been efforts to link meta-analytic maps of disorder-related abnormalities or MRI 'lesions' to the complex topology of the normative connectome. This work has highlighted the general importance of network hubs as hotspots for concentration of cortical grey-matter deficits in schizophrenia, Alzheimer's disease and other disorders. Finally, we show how by incorporating cellular and transcriptional data on individual nodes with network models of the connectome, studies have begun to elucidate the microscopic mechanisms underpinning the macroscopic organization of whole-brain networks. We argue that meta-connectomics is an exciting field, providing robust and integrative insights into brain organization that will likely play an important future role in consolidating network models of psychiatric disorders.

University Students' Meta-Modelling Knowledge

Science.gov (United States)

Krell, Moritz; Krüger, Dirk

2017-01-01

Background: As one part of scientific meta-knowledge, students' meta-modelling knowledge should be promoted on different educational levels such as primary school, secondary school and university. This study focuses on the assessment of university students' meta-modelling knowledge using a paper-pencil questionnaire. Purpose: The general purpose…

MIGRATE: A FOSS WEB MAPPING APPLICATION FOR EDUCATING AND RAISING AWARENESS ABOUT MIGRATION FLOWS IN EUROPE

Directory of Open Access Journals (Sweden)

M. A. Brovelli

2017-07-01

Full Text Available Recent years have seen a noticeable growth in migration flows from Africa and Middle East to Southern Europe, thus generating a remarkable increase of attention on media and public opinion, sometimes resulting in stereotypes and prejudices. Funded by the European Commission – Joint Research Centre through the MYGEOSS program, MIGRation pATtterns in Europe (MIGRATE aims at educating the citizens about migration fluxes in Europe using a gamification approach based on a trivia game. MIGRATE is completely developed with Free and Open Source Software. On the server-side Django is used to define the models that handle all the required data and tables are created in a PostgreSQL database. Questions and answers are sent in JSON format to the client, while the geospatial layers in GeoJSON format are rendered on the map interface using OpenLayers 3. Bootstrap, HTML5 and CSS3 are used for responsive design, while the jQuery library is used to ease the JavaScript programming. All the data sources used within MIGRATE are available as full and open access with no restrictions for reuse, except for the obligation to mention the source of the input data. Exploited data sources include OpenStreetMap for geospatial information, and UNHCR, IOM, Eurostat and The Migrant’s Files project for non-geospatial information. Overall, data shows how the users’ perceptions change while playing and that players’ awareness of migration-related problems increases with the number of games played. The source code of MIGRATE and the collected data are available respectively under the EU Public License (EUPL and the CC BY 4.0 license.

SpecPad: device-independent NMR data visualization and processing based on the novel DART programming language and Html5 Web technology.

Science.gov (United States)

Guigas, Bruno

2017-09-01

SpecPad is a new device-independent software program for the visualization and processing of one-dimensional and two-dimensional nuclear magnetic resonance (NMR) time domain (FID) and frequency domain (spectrum) data. It is the result of a project to investigate whether the novel programming language DART, in combination with Html5 Web technology, forms a suitable base to write an NMR data evaluation software which runs on modern computing devices such as Android, iOS, and Windows tablets as well as on Windows, Linux, and Mac OS X desktop PCs and notebooks. Another topic of interest is whether this technique also effectively supports the required sophisticated graphical and computational algorithms. SpecPad is device-independent because DART's compiled executable code is JavaScript and can, therefore, be run by the browsers of PCs and tablets. Because of Html5 browser cache technology, SpecPad may be operated off-line. Network access is only required during data import or export, e.g. via a Cloud service, or for software updates. A professional and easy to use graphical user interface consistent across all hardware platforms supports touch screen features on mobile devices for zooming and panning and for NMR-related interactive operations such as phasing, integration, peak picking, or atom assignment. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

Conducting Meta-Analysis Using SAS

CERN Document Server

Arthur, Winfried; Huffcutt, Allen I; Arthur, Winfred

2001-01-01

Conducting Meta-Analysis Using SAS reviews the meta-analysis statistical procedure and shows the reader how to conduct one using SAS. It presents and illustrates the use of the PROC MEANS procedure in SAS to perform the data computations called for by the two most commonly used meta-analytic procedures, the Hunter & Schmidt and Glassian approaches. This book serves as both an operational guide and user's manual by describing and explaining the meta-analysis procedures and then presenting the appropriate SAS program code for computing the pertinent statistics. The practical, step-by-step instru

Living network meta-analysis compared with pairwise meta-analysis in comparative effectiveness research: empirical study.

Science.gov (United States)

Nikolakopoulou, Adriani; Mavridis, Dimitris; Furukawa, Toshi A; Cipriani, Andrea; Tricco, Andrea C; Straus, Sharon E; Siontis, George C M; Egger, Matthias; Salanti, Georgia

2018-02-28

To examine whether the continuous updating of networks of prospectively planned randomised controlled trials (RCTs) ("living" network meta-analysis) provides strong evidence against the null hypothesis in comparative effectiveness of medical interventions earlier than the updating of conventional, pairwise meta-analysis. Empirical study of the accumulating evidence about the comparative effectiveness of clinical interventions. Database of network meta-analyses of RCTs identified through searches of Medline, Embase, and the Cochrane Database of Systematic Reviews until 14 April 2015. Network meta-analyses published after January 2012 that compared at least five treatments and included at least 20 RCTs. Clinical experts were asked to identify in each network the treatment comparison of greatest clinical interest. Comparisons were excluded for which direct and indirect evidence disagreed, based on side, or node, splitting test (Pmeta-analyses were performed for each selected comparison. Monitoring boundaries of statistical significance were constructed and the evidence against the null hypothesis was considered to be strong when the monitoring boundaries were crossed. A significance level was defined as α=5%, power of 90% (β=10%), and an anticipated treatment effect to detect equal to the final estimate from the network meta-analysis. The frequency and time to strong evidence was compared against the null hypothesis between pairwise and network meta-analyses. 49 comparisons of interest from 44 networks were included; most (n=39, 80%) were between active drugs, mainly from the specialties of cardiology, endocrinology, psychiatry, and rheumatology. 29 comparisons were informed by both direct and indirect evidence (59%), 13 by indirect evidence (27%), and 7 by direct evidence (14%). Both network and pairwise meta-analysis provided strong evidence against the null hypothesis for seven comparisons, but for an additional 10 comparisons only network meta-analysis provided

Longitudinal Meta-analysis

NARCIS (Netherlands)

Hox, J.J.; Maas, C.J.M.; Lensvelt-Mulders, G.J.L.M.

2004-01-01

The goal of meta-analysis is to integrate the research results of a number of studies on a specific topic. Characteristic for meta-analysis is that in general only the summary statistics of the studies are used and not the original data. When the published research results to be integrated

Meta-Teaching: Meaning and Strategy

Science.gov (United States)

Chen, Xiaoduan

2013-01-01

Meta-teaching is the knowledge and reflection on teaching based on meta-ideas. It is the teaching about teaching, a teaching process with practice consciously guided by thinking, inspiring teachers to teach more effectively. Meta-teaching is related to the knowledge, inspection and amendment of teaching activities in terms of their design,…

Meta-analysis a structural equation modeling approach

CERN Document Server

Cheung, Mike W-L

2015-01-01

Presents a novel approach to conducting meta-analysis using structural equation modeling. Structural equation modeling (SEM) and meta-analysis are two powerful statistical methods in the educational, social, behavioral, and medical sciences. They are often treated as two unrelated topics in the literature. This book presents a unified framework on analyzing meta-analytic data within the SEM framework, and illustrates how to conduct meta-analysis using the metaSEM package in the R statistical environment. Meta-Analysis: A Structural Equation Modeling Approach begins by introducing the impo

The Meta-Analytic Big Bang

Science.gov (United States)

Shadish, William R.; Lecy, Jesse D.

2015-01-01

This article looks at the impact of meta-analysis and then explores why meta-analysis was developed at the time and by the scholars it did in the social sciences in the 1970s. For the first problem, impact, it examines the impact of meta-analysis using citation network analysis. The impact is seen in the sciences, arts and humanities, and on such…

MetaSeq: privacy preserving meta-analysis of sequencing-based association studies.

Science.gov (United States)

Singh, Angad Pal; Zafer, Samreen; Pe'er, Itsik

2013-01-01

Human genetics recently transitioned from GWAS to studies based on NGS data. For GWAS, small effects dictated large sample sizes, typically made possible through meta-analysis by exchanging summary statistics across consortia. NGS studies groupwise-test for association of multiple potentially-causal alleles along each gene. They are subject to similar power constraints and therefore likely to resort to meta-analysis as well. The problem arises when considering privacy of the genetic information during the data-exchange process. Many scoring schemes for NGS association rely on the frequency of each variant thus requiring the exchange of identity of the sequenced variant. As such variants are often rare, potentially revealing the identity of their carriers and jeopardizing privacy. We have thus developed MetaSeq, a protocol for meta-analysis of genome-wide sequencing data by multiple collaborating parties, scoring association for rare variants pooled per gene across all parties. We tackle the challenge of tallying frequency counts of rare, sequenced alleles, for metaanalysis of sequencing data without disclosing the allele identity and counts, thereby protecting sample identity. This apparent paradoxical exchange of information is achieved through cryptographic means. The key idea is that parties encrypt identity of genes and variants. When they transfer information about frequency counts in cases and controls, the exchanged data does not convey the identity of a mutation and therefore does not expose carrier identity. The exchange relies on a 3rd party, trusted to follow the protocol although not trusted to learn about the raw data. We show applicability of this method to publicly available exome-sequencing data from multiple studies, simulating phenotypic information for powerful meta-analysis. The MetaSeq software is publicly available as open source.

The Influence of Judgment Calls on Meta-Analytic Findings.

Science.gov (United States)

Tarrahi, Farid; Eisend, Martin

2016-01-01

Previous research has suggested that judgment calls (i.e., methodological choices made in the process of conducting a meta-analysis) have a strong influence on meta-analytic findings and question their robustness. However, prior research applies case study comparison or reanalysis of a few meta-analyses with a focus on a few selected judgment calls. These studies neglect the fact that different judgment calls are related to each other and simultaneously influence the outcomes of a meta-analysis, and that meta-analytic findings can vary due to non-judgment call differences between meta-analyses (e.g., variations of effects over time). The current study analyzes the influence of 13 judgment calls in 176 meta-analyses in marketing research by applying a multivariate, multilevel meta-meta-analysis. The analysis considers simultaneous influences from different judgment calls on meta-analytic effect sizes and controls for alternative explanations based on non-judgment call differences between meta-analyses. The findings suggest that judgment calls have only a minor influence on meta-analytic findings, whereas non-judgment call differences between meta-analyses are more likely to explain differences in meta-analytic findings. The findings support the robustness of meta-analytic results and conclusions.

The meta-analytic big bang.

Science.gov (United States)

Shadish, William R; Lecy, Jesse D

2015-09-01

This article looks at the impact of meta-analysis and then explores why meta-analysis was developed at the time and by the scholars it did in the social sciences in the 1970s. For the first problem, impact, it examines the impact of meta-analysis using citation network analysis. The impact is seen in the sciences, arts and humanities, and on such contemporaneous developments as multilevel modeling, medical statistics, qualitative methods, program evaluation, and single-case design. Using a constrained snowball sample of citations, we highlight key articles that are either most highly cited or most central to the systematic review network. Then, the article examines why meta-analysis came to be in the 1970s in the social sciences through the work of Gene Glass, Robert Rosenthal, and Frank Schmidt, each of whom developed similar theories of meta-analysis at about the same time. The article ends by explaining how Simonton's chance configuration theory and Campbell's evolutionary epistemology can illuminate why meta-analysis occurred with these scholars when it did and not in medical sciences. Copyright © 2015 John Wiley & Sons, Ltd.

Causal Meta-Analysis : Methodology and Applications

NARCIS (Netherlands)

Bax, L.J.

2009-01-01

Meta-analysis is a statistical method to summarize research data from multiple studies in a quantitative manner. This dissertation addresses a number of methodological topics in causal meta-analysis and reports the development and validation of meta-analysis software. In the first (methodological)

Online open neuroimaging mass meta-analysis

DEFF Research Database (Denmark)

Nielsen, Finn Årup; Kempton, Matthew J.; Williams, Steven C. R.

We describe a system for meta-analysis where a wiki stores numerical data in a simple format and a web service performs the numerical computation. We initially apply the system on multiple meta-analyses of structural neuroimaging data results. The described system allows for mass meta-analysis, e...

Dealing with feelings: positive and negative discrete emotions as mediators of news framing effects

NARCIS (Netherlands)

Lecheler, S.; Schuck, A.R.T.; de Vreese, C.H.

2012-01-01

http://citation.allacademic.com/meta/p552756_index.htmlThe underlying psychological processes that enable framing effects are often described as cognitive. Yet, a large body of research suggests that decision-making and opinion formation are also guided by emotionality. As a result, a number of

Application software, domain-specific languages, and language design assistants

NARCIS (Netherlands)

J. Heering (Jan)

2000-01-01

textabstractWhile application software does the real work, domain-specific languages (DSLs) are tools to help produce it efficiently, and language design assistants in turn are meta-tools to help produce DSLs quickly. DSLs are already in wide use (HTML for web pages, Excel macros for spreadsheet

Grey literature in meta-analyses.

Science.gov (United States)

Conn, Vicki S; Valentine, Jeffrey C; Cooper, Harris M; Rantz, Marilyn J

2003-01-01

In meta-analysis, researchers combine the results of individual studies to arrive at cumulative conclusions. Meta-analysts sometimes include "grey literature" in their evidential base, which includes unpublished studies and studies published outside widely available journals. Because grey literature is a source of data that might not employ peer review, critics have questioned the validity of its data and the results of meta-analyses that include it. To examine evidence regarding whether grey literature should be included in meta-analyses and strategies to manage grey literature in quantitative synthesis. This article reviews evidence on whether the results of studies published in peer-reviewed journals are representative of results from broader samplings of research on a topic as a rationale for inclusion of grey literature. Strategies to enhance access to grey literature are addressed. The most consistent and robust difference between published and grey literature is that published research is more likely to contain results that are statistically significant. Effect size estimates of published research are about one-third larger than those of unpublished studies. Unfunded and small sample studies are less likely to be published. Yet, importantly, methodological rigor does not differ between published and grey literature. Meta-analyses that exclude grey literature likely (a) over-represent studies with statistically significant findings, (b) inflate effect size estimates, and (c) provide less precise effect size estimates than meta-analyses including grey literature. Meta-analyses should include grey literature to fully reflect the existing evidential base and should assess the impact of methodological variations through moderator analysis.

Marital status integration and suicide: A meta-analysis and meta-regression.

Science.gov (United States)

Kyung-Sook, Woo; SangSoo, Shin; Sangjin, Shin; Young-Jeon, Shin

2018-01-01

Marital status is an index of the phenomenon of social integration within social structures and has long been identified as an important predictor suicide. However, previous meta-analyses have focused only on a particular marital status, or not sufficiently explored moderators. A meta-analysis of observational studies was conducted to explore the relationships between marital status and suicide and to understand the important moderating factors in this association. Electronic databases were searched to identify studies conducted between January 1, 2000 and June 30, 2016. We performed a meta-analysis, subgroup analysis, and meta-regression of 170 suicide risk estimates from 36 publications. Using random effects model with adjustment for covariates, the study found that the suicide risk for non-married versus married was OR = 1.92 (95% CI: 1.75-2.12). The suicide risk was higher for non-married individuals aged analysis by gender, non-married men exhibited a greater risk of suicide than their married counterparts in all sub-analyses, but women aged 65 years or older showed no significant association between marital status and suicide. The suicide risk in divorced individuals was higher than for non-married individuals in both men and women. The meta-regression showed that gender, age, and sample size affected between-study variation. The results of the study indicated that non-married individuals have an aggregate higher suicide risk than married ones. In addition, gender and age were confirmed as important moderating factors in the relationship between marital status and suicide. Copyright © 2017 Elsevier Ltd. All rights reserved.

OHBM 2017: Practical intensity based meta-analysis

OpenAIRE

Maumet, Camille

2017-01-01

"Practical intensity-based meta-analysis" slides from my talk in the OHBM 2017 educational talk on Neuroimaging meta-analysis.http://www.humanbrainmapping.org/files/2017/ED Courses/Neuroimaging Meta-Analysis.pdf

Formalizing the definition of meta-analysis in Molecular Ecology.

Science.gov (United States)

ArchMiller, Althea A; Bauer, Eric F; Koch, Rebecca E; Wijayawardena, Bhagya K; Anil, Ammu; Kottwitz, Jack J; Munsterman, Amelia S; Wilson, Alan E

2015-08-01

Meta-analysis, the statistical synthesis of pertinent literature to develop evidence-based conclusions, is relatively new to the field of molecular ecology, with the first meta-analysis published in the journal Molecular Ecology in 2003 (Slate & Phua 2003). The goal of this article is to formalize the definition of meta-analysis for the authors, editors, reviewers and readers of Molecular Ecology by completing a review of the meta-analyses previously published in this journal. We also provide a brief overview of the many components required for meta-analysis with a more specific discussion of the issues related to the field of molecular ecology, including the use and statistical considerations of Wright's FST and its related analogues as effect sizes in meta-analysis. We performed a literature review to identify articles published as 'meta-analyses' in Molecular Ecology, which were then evaluated by at least two reviewers. We specifically targeted Molecular Ecology publications because as a flagship journal in this field, meta-analyses published in Molecular Ecology have the potential to set the standard for meta-analyses in other journals. We found that while many of these reviewed articles were strong meta-analyses, others failed to follow standard meta-analytical techniques. One of these unsatisfactory meta-analyses was in fact a secondary analysis. Other studies attempted meta-analyses but lacked the fundamental statistics that are considered necessary for an effective and powerful meta-analysis. By drawing attention to the inconsistency of studies labelled as meta-analyses, we emphasize the importance of understanding the components of traditional meta-analyses to fully embrace the strengths of quantitative data synthesis in the field of molecular ecology. © 2015 John Wiley & Sons Ltd.

What's the Meta?

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Schamiloglu, Edl; Fuks, Mikhail

2010-11-01

The term ``Metamaterial'' was first coined in 1999 by Rodger Walser, University of Texas [B. Munk, Metamaterials: Critique and Alternatives/ (John Wiley & Sons, New York, NY, 2009)]. His definition is as follows: Metamaterials are macroscopic composites having man-made, three-dimensional, periodic cellular architecture designed to produce an optimized combination, not available in nature, of two or more responses to specific excitation./ He chose ``meta'' as the prefix from the Greek work meta meaning beyond. The taxonomy of meta-materials is a problem. It seems that there is no one satisfactory definition that does not restrict a class of worthy meta-materials. This presentation reviews past work on the interaction of high power electromagnetic radiation with 1-D photonic crystals. The purpose of this work was to demonstrate the use of a dielectric to focus the microwave wavebeam and to reflect it quasi-optically. In these experiments using a short pulse SINUS-6 accelerator-driven backward-wave oscillator (BWO) no deleterious effects of the high power electromagnetic fields were observed on the photonic crystal. In addition, planned experiments for an overmoded BWO whose slow wave structure is made from individual wires will be described. This latter has novel mode selection features, in addition to high power handling capability.

Meta-Literacy in Gameworlds

DEFF Research Database (Denmark)

Pajares Tosca, Susana; Carrasco Yelmo, Silviano

2016-01-01

This paper proposes the notion of “meta-literacy”, understood as the player´s ability to navigate between spheres of reality and/or cross boundaries when interacting with a gameworld. We examine how meta-aesthetics functions in videogames and argue that it is relevant at both the fictional level...

An object-oriented approach to deploying highly configurable Web interfaces for the ATLAS experiment

International Nuclear Information System (INIS)

Lange, Bruno; Maidantchik, Carmen; Pavani, Varlen; Arosa, Breno; Abreu, Igor; Pommes, Kathy

2015-01-01

The ATLAS Technical Coordination disposes of 17 Web systems to support its operation. These applications, whilst ranging from managing the process of publishing scientific papers to monitoring radiation levels in the equipment in the experimental cavern, are constantly prone to changes in requirements due to the collaborative nature of the experiment and its management. In this context, a Web framework is proposed to unify the generation of the supporting interfaces. FENCE assembles classes to build applications by making extensive use of JSON configuration files. It relies heavily on Glance, a technology that was set forth in 2003 to create an abstraction layer on top of the heterogeneous sources that store the technical coordination data. Once Glance maps out the database modeling, records can be referenced in the configuration files by wrapping unique identifiers around double enclosing brackets. The deployed content can be individually secured by attaching clearance attributes to their description thus ensuring that view/edit privileges are granted to eligible users only. The framework also provides tools for securely writing into a database. Fully HTML5-compliant multi-step forms can be generated from their JSON description to assure that the submitted data comply with a series of constraints. Input validation is carried out primarily on the server- side but, following progressive enhancement guidelines, verification might also be performed on the client-side by enabling specific markup data attributes which are then handed over to the jQuery validation plug-in. User monitoring is accomplished by thoroughly logging user requests along with any POST data. Documentation is built from the source code using the phpDocumentor tool and made readily available for developers online. Fence, therefore, speeds up the implementation of Web interfaces and reduces the response time to requirement changes by minimizing maintenance overhead. (paper)

An object-oriented approach to deploying highly configurable Web interfaces for the ATLAS experiment

Science.gov (United States)

Lange, Bruno; Maidantchik, Carmen; Pommes, Kathy; Pavani, Varlen; Arosa, Breno; Abreu, Igor

2015-12-01

The ATLAS Technical Coordination disposes of 17 Web systems to support its operation. These applications, whilst ranging from managing the process of publishing scientific papers to monitoring radiation levels in the equipment in the experimental cavern, are constantly prone to changes in requirements due to the collaborative nature of the experiment and its management. In this context, a Web framework is proposed to unify the generation of the supporting interfaces. FENCE assembles classes to build applications by making extensive use of JSON configuration files. It relies heavily on Glance, a technology that was set forth in 2003 to create an abstraction layer on top of the heterogeneous sources that store the technical coordination data. Once Glance maps out the database modeling, records can be referenced in the configuration files by wrapping unique identifiers around double enclosing brackets. The deployed content can be individually secured by attaching clearance attributes to their description thus ensuring that view/edit privileges are granted to eligible users only. The framework also provides tools for securely writing into a database. Fully HTML5-compliant multi-step forms can be generated from their JSON description to assure that the submitted data comply with a series of constraints. Input validation is carried out primarily on the server- side but, following progressive enhancement guidelines, verification might also be performed on the client-side by enabling specific markup data attributes which are then handed over to the jQuery validation plug-in. User monitoring is accomplished by thoroughly logging user requests along with any POST data. Documentation is built from the source code using the phpDocumentor tool and made readily available for developers online. Fence, therefore, speeds up the implementation of Web interfaces and reduces the response time to requirement changes by minimizing maintenance overhead.

An overview of meta-analysis for clinicians

Science.gov (United States)

Lee, Young Ho

2018-01-01

The number of medical studies being published is increasing exponentially, and clinicians must routinely process large amounts of new information. Moreover, the results of individual studies are often insufficient to provide confident answers, as their results are not consistently reproducible. A meta-analysis is a statistical method for combining the results of different studies on the same topic and it may resolve conflicts among studies. Meta-analysis is being used increasingly and plays an important role in medical research. This review introduces the basic concepts, steps, advantages, and caveats of meta-analysis, to help clinicians understand it in clinical practice and research. A major advantage of a meta-analysis is that it produces a precise estimate of the effect size, with considerably increased statistical power, which is important when the power of the primary study is limited because of a small sample size. A meta-analysis may yield conclusive results when individual studies are inconclusive. Furthermore, meta-analyses investigate the source of variation and different effects among subgroups. In summary, a meta-analysis is an objective, quantitative method that provides less biased estimates on a specific topic. Understanding how to conduct a meta-analysis aids clinicians in the process of making clinical decisions. PMID:29277096

An overview of meta-analysis for clinicians.

Science.gov (United States)

Lee, Young Ho

2018-03-01

The number of medical studies being published is increasing exponentially, and clinicians must routinely process large amounts of new information. Moreover, the results of individual studies are often insufficient to provide confident answers, as their results are not consistently reproducible. A meta-analysis is a statistical method for combining the results of different studies on the same topic and it may resolve conflicts among studies. Meta-analysis is being used increasingly and plays an important role in medical research. This review introduces the basic concepts, steps, advantages, and caveats of meta-analysis, to help clinicians understand it in clinical practice and research. A major advantage of a meta-analysis is that it produces a precise estimate of the effect size, with considerably increased statistical power, which is important when the power of the primary study is limited because of a small sample size. A meta-analysis may yield conclusive results when individual studies are inconclusive. Furthermore, meta-analyses investigate the source of variation and different effects among subgroups. In summary, a meta-analysis is an objective, quantitative method that provides less biased estimates on a specific topic. Understanding how to conduct a meta-analysis aids clinicians in the process of making clinical decisions.

A Microsoft-Excel-based tool for running and critically appraising network meta-analyses--an overview and application of NetMetaXL.

Science.gov (United States)

Brown, Stephen; Hutton, Brian; Clifford, Tammy; Coyle, Doug; Grima, Daniel; Wells, George; Cameron, Chris

2014-09-29

The use of network meta-analysis has increased dramatically in recent years. WinBUGS, a freely available Bayesian software package, has been the most widely used software package to conduct network meta-analyses. However, the learning curve for WinBUGS can be daunting, especially for new users. Furthermore, critical appraisal of network meta-analyses conducted in WinBUGS can be challenging given its limited data manipulation capabilities and the fact that generation of graphical output from network meta-analyses often relies on different software packages than the analyses themselves. We developed a freely available Microsoft-Excel-based tool called NetMetaXL, programmed in Visual Basic for Applications, which provides an interface for conducting a Bayesian network meta-analysis using WinBUGS from within Microsoft Excel. . This tool allows the user to easily prepare and enter data, set model assumptions, and run the network meta-analysis, with results being automatically displayed in an Excel spreadsheet. It also contains macros that use NetMetaXL's interface to generate evidence network diagrams, forest plots, league tables of pairwise comparisons, probability plots (rankograms), and inconsistency plots within Microsoft Excel. All figures generated are publication quality, thereby increasing the efficiency of knowledge transfer and manuscript preparation. We demonstrate the application of NetMetaXL using data from a network meta-analysis published previously which compares combined resynchronization and implantable defibrillator therapy in left ventricular dysfunction. We replicate results from the previous publication while demonstrating result summaries generated by the software. Use of the freely available NetMetaXL successfully demonstrated its ability to make running network meta-analyses more accessible to novice WinBUGS users by allowing analyses to be conducted entirely within Microsoft Excel. NetMetaXL also allows for more efficient and transparent

A Microsoft-Excel-based tool for running and critically appraising network meta-analyses—an overview and application of NetMetaXL

Science.gov (United States)

2014-01-01

Background The use of network meta-analysis has increased dramatically in recent years. WinBUGS, a freely available Bayesian software package, has been the most widely used software package to conduct network meta-analyses. However, the learning curve for WinBUGS can be daunting, especially for new users. Furthermore, critical appraisal of network meta-analyses conducted in WinBUGS can be challenging given its limited data manipulation capabilities and the fact that generation of graphical output from network meta-analyses often relies on different software packages than the analyses themselves. Methods We developed a freely available Microsoft-Excel-based tool called NetMetaXL, programmed in Visual Basic for Applications, which provides an interface for conducting a Bayesian network meta-analysis using WinBUGS from within Microsoft Excel. . This tool allows the user to easily prepare and enter data, set model assumptions, and run the network meta-analysis, with results being automatically displayed in an Excel spreadsheet. It also contains macros that use NetMetaXL’s interface to generate evidence network diagrams, forest plots, league tables of pairwise comparisons, probability plots (rankograms), and inconsistency plots within Microsoft Excel. All figures generated are publication quality, thereby increasing the efficiency of knowledge transfer and manuscript preparation. Results We demonstrate the application of NetMetaXL using data from a network meta-analysis published previously which compares combined resynchronization and implantable defibrillator therapy in left ventricular dysfunction. We replicate results from the previous publication while demonstrating result summaries generated by the software. Conclusions Use of the freely available NetMetaXL successfully demonstrated its ability to make running network meta-analyses more accessible to novice WinBUGS users by allowing analyses to be conducted entirely within Microsoft Excel. NetMetaXL also allows

Meta-Analysis at Middle Age: A Personal History

Science.gov (United States)

Glass, Gene V.

2015-01-01

The 40-year history of meta-analysis is traced from the vantage point of one of its originators. Research syntheses leading to the first examples of meta-analysis are identified. Early meta-analyses of the literature on psychotherapy outcomes and school class size are recounted. The influence on the development of meta-analysis of several…

Meta-data for a lot of LOD

NARCIS (Netherlands)

Rietveld, Laurens; Beek, Wouter; Hoekstra, Rinke; Schlobach, Stefan

2017-01-01

This paper introduces the LOD Laundromat meta-dataset, a continuously updated RDF meta-dataset that describes the documents crawled, cleaned and (re)published by the LOD Laundromat. This meta-dataset of over 110 million triples contains structural information for more than 650,000 documents (and

MicroRNA meta-signature of oral cancer: evidence from a meta-analysis.

Science.gov (United States)

Zeljic, Katarina; Jovanovic, Ivan; Jovanovic, Jasmina; Magic, Zvonko; Stankovic, Aleksandra; Supic, Gordana

2018-03-01

It was the aim of the study to identify commonly deregulated miRNAs in oral cancer patients by performing a meta-analysis of previously published miRNA expression profiles in cancer and matched normal non-cancerous tissue in such patients. Meta-analysis included seven independent studies analyzed by a vote-counting method followed by bioinformatic enrichment analysis. Amongst seven independent studies included in the meta-analysis, 20 miRNAs were found to be deregulated in oral cancer when compared with non-cancerous tissue. Eleven miRNAs were consistently up-regulated in three or more studies (miR-21-5p, miR-31-5p, miR-135b-5p, miR-31-3p, miR-93-5p, miR-34b-5p, miR-424-5p, miR-18a-5p, miR-455-3p, miR-450a-5p, miR-21-3p), and nine were down-regulated (miR-139-5p, miR-30a-3p, miR-376c-3p, miR-885-5p, miR-375, miR-486-5p, miR-411-5p, miR-133a-3p, miR-30a-5p). The meta-signature of identified miRNAs was functionally characterized by KEGG enrichment analysis. Twenty-four KEGG pathways were significantly enriched, and TGF-beta signaling was the most enriched signaling pathway. The highest number of meta-signature miRNAs was involved in the sphingolipid signaling pathway. Natural killer cell-mediated cytotoxicity was the pathway with most genes regulated by identified miRNAs. The rest of the enriched pathways in our miRNA list describe different malignancies and signaling. The identified miRNA meta-signature might be considered as a potential battery of biomarkers when distinguishing oral cancer tissue from normal, non-cancerous tissue. Further mechanistic studies are warranted in order to confirm and fully elucidate the role of deregulated miRNAs in oral cancer.

RAMESES publication standards: meta-narrative reviews

Directory of Open Access Journals (Sweden)

Wong Geoff

2013-01-01

Full Text Available Abstract Background Meta-narrative review is one of an emerging menu of new approaches to qualitative and mixed-method systematic review. A meta-narrative review seeks to illuminate a heterogeneous topic area by highlighting the contrasting and complementary ways in which researchers have studied the same or a similar topic. No previous publication standards exist for the reporting of meta-narrative reviews. This publication standard was developed as part of the RAMESES (Realist And MEta-narrative Evidence Syntheses: Evolving Standards project. The project's aim is to produce preliminary publication standards for meta-narrative reviews. Methods We (a collated and summarized existing literature on the principles of good practice in meta-narrative reviews; (b considered the extent to which these principles had been followed by published reviews, thereby identifying how rigor may be lost and how existing methods could be improved; (c used a three-round online Delphi method with an interdisciplinary panel of national and international experts in evidence synthesis, meta-narrative reviews, policy and/or publishing to produce and iteratively refine a draft set of methodological steps and publication standards; (d provided real-time support to ongoing meta-narrative reviews and the open-access RAMESES online discussion list so as to capture problems and questions as they arose; and (e synthesized expert input, evidence review and real-time problem analysis into a definitive set of standards. Results We identified nine published meta-narrative reviews, provided real-time support to four ongoing reviews and captured questions raised in the RAMESES discussion list. Through analysis and discussion within the project team, we summarized the published literature, and common questions and challenges into briefing materials for the Delphi panel, comprising 33 members. Within three rounds this panel had reached consensus on 20 key publication standards, with an

Metadata In, Library Out. A Simple, Robust Digital Library System

Directory of Open Access Journals (Sweden)

Tonio Loewald

2010-06-01

Full Text Available Tired of being held hostage to expensive systems that did not meet our needs, the University of Alabama Libraries developed an XML schema-agnostic, light-weight digital library delivery system based on the principles of "Keep It Simple, Stupid!" Metadata and derivatives reside in openly accessible web directories, which support the development of web agents and new usability software, as well as modification and complete retrieval at any time. The file name structure is echoed in the file system structure, enabling the delivery software to make inferences about relationships, sequencing, and complex object structure without having to encapsulate files in complex metadata schemas. The web delivery system, Acumen, is built of PHP, JSON, JavaScript and HTML5, using MySQL to support fielded searching. Recognizing that spreadsheets are more user-friendly than XML, an accompanying widget, Archivists Utility, transforms spreadsheets into MODS based on rules selected by the user. Acumen, Archivists Utility, and all supporting software scripts will be made available as open source.

lawn: An R client for the Turf JavaScript Library for Geospatial Analysis

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lawn is an R package to provide access to the geospatial analysis capabilities in the Turf javascript library. Turf expects data in GeoJSON format. Given that many datasets are now available natively in GeoJSON providing an easier method for conducting geospatial analyses on thes...

Protocol-developing meta-ethnography reporting guidelines (eMERGe).

Science.gov (United States)

France, E F; Ring, N; Noyes, J; Maxwell, M; Jepson, R; Duncan, E; Turley, R; Jones, D; Uny, I

2015-11-25

Designing and implementing high-quality health care services and interventions requires robustly synthesised evidence. Syntheses of qualitative research studies can provide evidence of patients' experiences of health conditions; intervention feasibility, appropriateness and acceptability to patients; and advance understanding of health care issues. The unique, interpretive, theory-based meta-ethnography synthesis approach is suited to conveying patients' views and developing theory to inform service design and delivery. However, meta-ethnography reporting is often poor quality, which discourages trust in, and use of, meta-ethnography findings. Users of evidence syntheses require reports that clearly articulate analytical processes and findings. Tailored research reporting guidelines can raise reporting standards but none exists for meta-ethnography. This study aims to create an evidence-based meta-ethnography reporting guideline articulating the methodological standards and depth of reporting required to improve reporting quality. The mixed-methods design of this National Institute of Health Research-funded study (http://www.stir.ac.uk/emerge/) follows good practice in research reporting guideline development comprising: (1) a methodological systematic review (PROSPERO registration: CRD42015024709) to identify recommendations and guidance in conducting/reporting meta-ethnography; (2) a review and audit of published meta-ethnographies to identify good practice principles and develop standards in conduct/reporting; (3) an online workshop and Delphi studies to agree guideline content with 45 international qualitative synthesis experts and 45 other stakeholders including patients; (4) development and wide dissemination of the guideline and its accompanying detailed explanatory document, a report template for National Institute of Health Research commissioned meta-ethnographies, and training materials on guideline use. Meta-ethnography, devised in the field of education

Meta-media and meta-communication - Revisiting the concept of genre in the digital media environment

Directory of Open Access Journals (Sweden)

Klaus Bruhn Jensen

2011-08-01

Full Text Available As analytical categories, genres have traditionally occupied a middle ground – between media as technologies and institutions, on the one hand, and discourses as material and modal forms of expression and interaction, on the other. With digitalization, the very concept of genre is in doubt: is the world wide web, Facebook, or the writing on its walls the genre? This article situat es genre in relation to the concepts of meta-media and meta-communication. First, I characterize the computer and the internet as metamedia, incorporating previous genres of embodied communication as well as mass communication. Second, I describe genres as a variety of meta-communication, which serves to configure communication in the first place. In conclusion, I discuss whether and how a category of meta-genres might help to account for some distinctive features of the digital media environment.

A Meta-Meta-Analysis: Empirical Review of Statistical Power, Type I Error Rates, Effect Sizes, and Model Selection of Meta-Analyses Published in Psychology

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Cafri, Guy; Kromrey, Jeffrey D.; Brannick, Michael T.

2010-01-01

This article uses meta-analyses published in "Psychological Bulletin" from 1995 to 2005 to describe meta-analyses in psychology, including examination of statistical power, Type I errors resulting from multiple comparisons, and model choice. Retrospective power estimates indicated that univariate categorical and continuous moderators, individual…

Network meta-analysis: an introduction for pharmacists.

Science.gov (United States)

Xu, Yina; Amiche, Mohamed Amine; Tadrous, Mina

2018-05-21

Network meta-analysis is a new tool used to summarize and compare studies for multiple interventions, irrespective of whether these interventions have been directly evaluated against each other. Network meta-analysis is quickly becoming the standard in conducting therapeutic reviews and clinical guideline development. However, little guidance is available to help pharmacists review network meta-analysis studies in their practice. Major institutions such as the Cochrane Collaboration, Agency for Healthcare Research and Quality, Canadian Agency for Drugs and Technologies in Health, and National Institute for Health and Care Excellence Decision Support Unit have endorsed utilizing network meta-analysis to establish therapeutic evidence and inform decision making. Our objective is to introduce this novel technique to pharmacy practitioners, and highlight key assumptions behind network meta-analysis studies.

Data analysis with the DIANA meta-scheduling approach

International Nuclear Information System (INIS)

Anjum, A; McClatchey, R; Willers, I

2008-01-01

The concepts, design and evaluation of the Data Intensive and Network Aware (DIANA) meta-scheduling approach for solving the challenges of data analysis being faced by CERN experiments are discussed in this paper. Our results suggest that data analysis can be made robust by employing fault tolerant and decentralized meta-scheduling algorithms supported in our DIANA meta-scheduler. The DIANA meta-scheduler supports data intensive bulk scheduling, is network aware and follows a policy centric meta-scheduling. In this paper, we demonstrate that a decentralized and dynamic meta-scheduling approach is an effective strategy to cope with increasing numbers of users, jobs and datasets. We present 'quality of service' related statistics for physics analysis through the application of a policy centric fair-share scheduling model. The DIANA meta-schedulers create a peer-to-peer hierarchy of schedulers to accomplish resource management that changes with evolving loads and is dynamic and adapts to the volatile nature of the resources

HTML5 e as possibilidades narrativas jornalísticas na infografia multimídia

Directory of Open Access Journals (Sweden)

Walter Teixeira Lima Junior

2015-12-01

Full Text Available O artigo propõe o estudo comparativo dos infográficos multimídia produzidos pelos sites Clarín.com, da Argentina e Folha.com, do Brasil. A pesquisa tem como objetivo verificar e analisar como esses dois importantes veículos de comunicação online da América Latina têm utilizado a tecnologia HTML5 e suas possibilidades interativas na narrativa jornalística. Para tanto, a análise vai se ater à infografia multimídia, que tem passado por profundas mudanças tecnológicas, alterando o formato e o conteúdo da notícia. Para abordar as possibilidades narrativas das tecnologias Flash e HTLM5 na produção de infográficos interativos, o trabalho compara as seções Infográficos, veiculada pela Folha.com, e Especiales Multimedia, do Clarín.com. O estudo, quantitativo e qualitativo, verificou quais recursos narrativos e informativos, ferramentas e tecnologias de linguagem de programação para Internet foram utilizados pelos dois meios de comunicação, com base no modelo de análise proposto por Alberto Cairo no livro Infografia 2.0.

MetaJC++: A flexible and automatic program transformation technique using meta framework

Science.gov (United States)

Beevi, Nadera S.; Reghu, M.; Chitraprasad, D.; Vinodchandra, S. S.

2014-09-01

Compiler is a tool to translate abstract code containing natural language terms to machine code. Meta compilers are available to compile more than one languages. We have developed a meta framework intends to combine two dissimilar programming languages, namely C++ and Java to provide a flexible object oriented programming platform for the user. Suitable constructs from both the languages have been combined, thereby forming a new and stronger Meta-Language. The framework is developed using the compiler writing tools, Flex and Yacc to design the front end of the compiler. The lexer and parser have been developed to accommodate the complete keyword set and syntax set of both the languages. Two intermediate representations have been used in between the translation of the source program to machine code. Abstract Syntax Tree has been used as a high level intermediate representation that preserves the hierarchical properties of the source program. A new machine-independent stack-based byte-code has also been devised to act as a low level intermediate representation. The byte-code is essentially organised into an output class file that can be used to produce an interpreted output. The results especially in the spheres of providing C++ concepts in Java have given an insight regarding the potential strong features of the resultant meta-language.

Managerial Meta-knowledge, Uncertainty, and Adaptation

DEFF Research Database (Denmark)

Jensen, Henrik; Foss, Nicolai Juul

"Managerial Meta-Knowledge, Uncertainty, and Adaptation: Governance Choice when Firms do not Know their Capabilities" Much research on economic organization (e.g., transaction cost economics) is based on an assumption that firms accurately know their own capabilities. In terms of what managers know...... about the resources of the firm (including employee knowledge) we argue that this amounts to an assumption of perfect managerial meta-knowledge. However, research streams on resource cognition, transaction memory and organizational self- knowledge suggests that this assumption is not in general...... warranted. We examine the implications for economic organization of less-than-perfect managerial meta-knowledge. Specifically, we show that imperfect managerial meta- knowledge is a cause of surprises in contractual relationships, affects the ability of coordinated adaptation, and an opportunism...

Sistem Monitoring Online Kualitas Air Akuakultur untuk Tambak Udang Menggunakan Aplikasi Berbasis Android

Directory of Open Access Journals (Sweden)

Priyani Kusrini

2016-12-01

Full Text Available Pemantauan kualitas air di tambak udang yang efektif sangat dibutuhkan agar produksi udang meningkat. Oleh karena itu, pada penelitian ini telah dibuat aplikasi sistem online monitoring kualitas air tambak udang berbasis android. Pengambilan data parameter sensor dilakukan di kampus LIPI menggunakan stasiun sensor yang datanya ditransmisikan ke data logger untuk selanjutnya dikirimkan ke website. Data yang diperoleh dari website berupa data php (Hyper Text Preprocessor dan kemudian diubah menjadi data JSON (Java Script Object Notation. Parsing data dilakukan dengan menggunakan fungsi json_encode untuk membuat string JSON dari objek dan array sehingga data dapat dibaca di Android Studio. Aplikasi ini sangat mudah dioperasikan dan sangat efisien.

Systematic review, meta-analysis, and meta-regression: Successful second-line treatment for Helicobacter pylori.

Science.gov (United States)

Muñoz, Neus; Sánchez-Delgado, Jordi; Baylina, Mireia; Puig, Ignasi; López-Góngora, Sheila; Suarez, David; Calvet, Xavier

2018-06-01

Multiple Helicobacter pylori second-line schedules have been described as potentially useful. It remains unclear, however, which are the best combinations, and which features of second-line treatments are related to better cure rates. The aim of this study was to determine that second-line treatments achieved excellent (>90%) cure rates by performing a systematic review and when possible a meta-analysis. A meta-regression was planned to determine the characteristics of treatments achieving excellent cure rates. A systematic review for studies evaluating second-line Helicobacter pylori treatment was carried out in multiple databases. A formal meta-analysis was performed when an adequate number of comparative studies was found, using RevMan5.3. A meta-regression for evaluating factors predicting cure rates >90% was performed using Stata Statistical Software. The systematic review identified 115 eligible studies, including 203 evaluable treatment arms. The results were extremely heterogeneous, with 61 treatment arms (30%) achieving optimal (>90%) cure rates. The meta-analysis favored quadruple therapies over triple (83.2% vs 76.1%, OR: 0.59:0.38-0.93; P = .02) and 14-day quadruple treatments over 7-day treatments (91.2% vs 81.5%, OR; 95% CI: 0.42:0.24-0.73; P = .002), although the differences were significant only in the per-protocol analysis. The meta-regression did not find any particular characteristics of the studies to be associated with excellent cure rates. Second-line Helicobacter pylori treatments achieving>90% cure rates are extremely heterogeneous. Quadruple therapy and 14-day treatments seem better than triple therapies and 7-day ones. No single characteristic of the treatments was related to excellent cure rates. Future approaches suitable for infectious diseases-thus considering antibiotic resistances-are needed to design rescue treatments that consistently achieve excellent cure rates. © 2018 John Wiley & Sons Ltd.

On termination of meta-programs

NARCIS (Netherlands)

Serebrenik, A.; De Schreye, D.; Nieuwenhuis, R.; Voronkov, A.

2001-01-01

The term meta-programming refers to the ability of writing programs that have other programs as data and exploit their semantics [4]. The choice of logic programming as a basis for meta-programming offers a number of practical and theoretical advantages. One of them is the possibility of tackling

Meta-Analysis of Coefficient Alpha

Science.gov (United States)

Rodriguez, Michael C.; Maeda, Yukiko

2006-01-01

The meta-analysis of coefficient alpha across many studies is becoming more common in psychology by a methodology labeled reliability generalization. Existing reliability generalization studies have not used the sampling distribution of coefficient alpha for precision weighting and other common meta-analytic procedures. A framework is provided for…

Minireview: Mode of action of meta-diamide insecticides.

Science.gov (United States)

Nakao, Toshifumi; Banba, Shinichi

2015-06-01

Meta-diamides [3-benzamido-N-(4-(perfluoropropan-2-yl)phenyl)benzamides] are a distinct class of RDL GABA receptor noncompetitive antagonists showing high insecticidal activity against Spodoptera litura. The mode of action of the meta-diamides was demonstrated to be distinct from that of conventional noncompetitive antagonists (NCAs) such as fipronil, picrotoxin, lindane, dieldrin, and α-endosulfan. It was suggested that meta-diamides act at or near G336 in the M3 region of the Drosophila RDL GABA receptor. Although the site of action of the meta-diamides appears to overlap with that of macrocyclic lactones including avermectins and milbemycins, differential effects of mutations on the actions of the meta-diamides and the macrocyclic lactones were observed. Molecular modeling studies revealed that the meta-diamides may bind to an inter-subunit pocket near G336 in the Drosophila RDL GABA receptor better when in the closed state, which is distinct from the NCA-binding site, which is in a channel formed by M2s. In contrast, the macrocyclic lactones were suggested to bind to an inter-subunit pocket near G336 in the Drosophila RDL GABA receptor when in the open state. Furthermore, mechanisms underlying the high selectivity of meta-diamides are discussed. This minireview highlights the unique features of novel meta-diamide insecticides and demonstrates why meta-diamides are anticipated to become prominent insecticides that are effective against pests resistant to cyclodienes and fipronil. Copyright © 2014 Elsevier Inc. All rights reserved.

Investigation of publication bias in meta-analyses of diagnostic test accuracy: a meta-epidemiological study

NARCIS (Netherlands)

van Enst, W. Annefloor; Ochodo, Eleanor; Scholten, Rob J. P. M.; Hooft, Lotty; Leeflang, Mariska M.

2014-01-01

The validity of a meta-analysis can be understood better in light of the possible impact of publication bias. The majority of the methods to investigate publication bias in terms of small study-effects are developed for meta-analyses of intervention studies, leaving authors of diagnostic test

Rethinking Meta-Analysis: Applications for Air Pollution Data and Beyond

Science.gov (United States)

Goodman, Julie E; Petito Boyce, Catherine; Sax, Sonja N; Beyer, Leslie A; Prueitt, Robyn L

2015-01-01

Meta-analyses offer a rigorous and transparent systematic framework for synthesizing data that can be used for a wide range of research areas, study designs, and data types. Both the outcome of meta-analyses and the meta-analysis process itself can yield useful insights for answering scientific questions and making policy decisions. Development of the National Ambient Air Quality Standards illustrates many potential applications of meta-analysis. These applications demonstrate the strengths and limitations of meta-analysis, issues that arise in various data realms, how meta-analysis design choices can influence interpretation of results, and how meta-analysis can be used to address bias and heterogeneity. Reviewing available data from a meta-analysis perspective can provide a useful framework and impetus for identifying and refining strategies for future research. Moreover, increased pervasiveness of a meta-analysis mindset—focusing on how the pieces of the research puzzle fit together—would benefit scientific research and data syntheses regardless of whether or not a quantitative meta-analysis is undertaken. While an individual meta-analysis can only synthesize studies addressing the same research question, the results of separate meta-analyses can be combined to address a question encompassing multiple data types. This observation applies to any scientific or policy area where information from a variety of disciplines must be considered to address a broader research question. PMID:25969128

A type-driven approach to concrete meta programming.

NARCIS (Netherlands)

J.J. Vinju (Jurgen)

2005-01-01

textabstractApplications that manipulate programs as data are called meta programs. Examples of meta programs are compilers, source-to-source translators and code generators. Meta programming can be supported by the ability to represent program fragments in concrete syntax instead of abstract

78 FR 52571 - Tennessee Valley Authority, Browns Ferry Nuclear Plant, Unit 1; Applications and Amendments to...

Science.gov (United States)

2013-08-23

... the NRC's E-Filing system does not support unlisted software, and the NRC Meta System Help Desk will... submitting a document to the NRC in accordance with the E-Filing rule, the participant must file the document... http://www.nrc.gov/site-help/e-submittals.html . A filing is considered complete at the time the...

Statistical Power in Meta-Analysis

Science.gov (United States)

Liu, Jin

2015-01-01

Statistical power is important in a meta-analysis study, although few studies have examined the performance of simulated power in meta-analysis. The purpose of this study is to inform researchers about statistical power estimation on two sample mean difference test under different situations: (1) the discrepancy between the analytical power and…

Trial Sequential Analysis in systematic reviews with meta-analysis

Directory of Open Access Journals (Sweden)

Jørn Wetterslev

2017-03-01

Full Text Available Abstract Background Most meta-analyses in systematic reviews, including Cochrane ones, do not have sufficient statistical power to detect or refute even large intervention effects. This is why a meta-analysis ought to be regarded as an interim analysis on its way towards a required information size. The results of the meta-analyses should relate the total number of randomised participants to the estimated required meta-analytic information size accounting for statistical diversity. When the number of participants and the corresponding number of trials in a meta-analysis are insufficient, the use of the traditional 95% confidence interval or the 5% statistical significance threshold will lead to too many false positive conclusions (type I errors and too many false negative conclusions (type II errors. Methods We developed a methodology for interpreting meta-analysis results, using generally accepted, valid evidence on how to adjust thresholds for significance in randomised clinical trials when the required sample size has not been reached. Results The Lan-DeMets trial sequential monitoring boundaries in Trial Sequential Analysis offer adjusted confidence intervals and restricted thresholds for statistical significance when the diversity-adjusted required information size and the corresponding number of required trials for the meta-analysis have not been reached. Trial Sequential Analysis provides a frequentistic approach to control both type I and type II errors. We define the required information size and the corresponding number of required trials in a meta-analysis and the diversity (D2 measure of heterogeneity. We explain the reasons for using Trial Sequential Analysis of meta-analysis when the actual information size fails to reach the required information size. We present examples drawn from traditional meta-analyses using unadjusted naïve 95% confidence intervals and 5% thresholds for statistical significance. Spurious conclusions in

META-ANALYSIS: THE WAY FORWARD IN MEDICAL DISCOVERY

African Journals Online (AJOL)

data, and (6) report the results. Define the Research Question. A meta-analysis begins with a question. Common questions addressed in meta-analyses are whether one. META-ANALYSIS: THE WAY FORWARD IN MEDICAL DISCOVERY. Akinyemi J.O. MSc (Medical Statistics), B Tech (Comp. Sc.) Correspondence:.

C-reactive protein gene polymorphisms and myocardial infarction risk: a meta-analysis and meta-regression.

Science.gov (United States)

Zhu, Yanbin; Liu, Tongku; He, Haitao; Sun, Yuqing; Zhuo, Fengling

2013-12-01

C-reactive protein (CRP), the classic acute-phase protein, plays an important role in the etiology of myocardial infarction (MI). Emerging evidence has shown that the common polymorphisms in the CRP gene may influence an individual's susceptibility to MI; but individually published studies showed inconclusive results. This meta-analysis aimed to derive a more precise estimation of the associations between CRP gene polymorphisms and MI risk. A literature search of PubMed, Embase, Web of Science, and China BioMedicine (CBM) databases was conducted on articles published before June 1st, 2013. Crude odds ratio (OR) with 95% confidence interval (CI) were calculated. Nine case-control studies were included with a total of 2992 MI patients and 4711 healthy controls. The meta-analysis results indicated that CRP rs3093059 (T>C) polymorphism was associated with decreased risk of MI, especially among Asian populations. However, similar associations were not observed in CRP rs1800947 (G>C) and rs2794521 (G>A) polymorphisms (all p>0.05) among both Asian and Caucasian populations. Univariate and multivariate meta-regression analyses showed that ethnicity may be a major source of heterogeneity. No publication bias was detected in this meta-analysis. In conclusion, the current meta-analysis indicates that CRP rs3093059 (T>C) polymorphism may be associated with decreased risk of MI, especially among Asian populations.

MetaMap

Data.gov (United States)

U.S. Department of Health & Human Services — MetaMap is a highly configurable application developed by the Lister Hill National Center for Biomedical Communications at the National Library of Medicine (NLM) to...

Meta-análise em pesquisas científicas: enfoque em metodologias Meta analysis in scientific research: a methodological approach

Directory of Open Access Journals (Sweden)

P.A. Lovatto

2007-07-01

Full Text Available Este texto descreve os princípios básicos de sistematização com enfoque em meta-análise. É apresentado o estado da arte da meta-análise, recuperando informações de sua evolução e metodologias básicas para sua realização. São descritos seus antecedentes históricos, os limites das abordagens clássicas de revisão de literatura, as bases conceituais, os objetivos e justificativas. É indicada uma metodologia geral para realização da meta-análise. São apresentados os critérios para a definição dos objetivos. São descritos os procedimentos de sistematização das informações e gestão de base bibliográfica de dados destinada aos estudos meta-analíticos (seleção, codificação, filtragem de dados. São apresentadas as análises mais comuns (gráfica, ponderações, a escolha do modelo estatístico (um fator explicativo qualitativo, um efeito qualitativo ou quantitativo, os fatores de interferência, os procedimentos pós-analíticos (variações residuais, heterogeneidade entre resultados. Em síntese, este texto mostra que a meta-análise é superior às formas tradicionais de revisão de literatura por estimar com maior precisão os efeitos dos tratamentos, ajustando-os para a heterogeneidade experimental. No entanto, a meta-análise exige os efeitos na sistematização e análise dos resultados da pesquisa.This text describes a basic approach of systematization with focus on meta-analysis. It is presented the art state of the meta-analysis, recovering information of its evolution and basic methodologies for its accomplishment. In this text are described the historical antecedents of meta-analysis, the limits of the classic approaches of literature review, the conceptual bases and the objectives. It is indicated a general methodology for meta-analysis procedures. The criteria for the definition of the objectives are presented. The procedures of the systematization and management of bibliographical data base selected to

Using structural equation modeling for network meta-analysis.

Science.gov (United States)

Tu, Yu-Kang; Wu, Yun-Chun

2017-07-14

Network meta-analysis overcomes the limitations of traditional pair-wise meta-analysis by incorporating all available evidence into a general statistical framework for simultaneous comparisons of several treatments. Currently, network meta-analyses are undertaken either within the Bayesian hierarchical linear models or frequentist generalized linear mixed models. Structural equation modeling (SEM) is a statistical method originally developed for modeling causal relations among observed and latent variables. As random effect is explicitly modeled as a latent variable in SEM, it is very flexible for analysts to specify complex random effect structure and to make linear and nonlinear constraints on parameters. The aim of this article is to show how to undertake a network meta-analysis within the statistical framework of SEM. We used an example dataset to demonstrate the standard fixed and random effect network meta-analysis models can be easily implemented in SEM. It contains results of 26 studies that directly compared three treatment groups A, B and C for prevention of first bleeding in patients with liver cirrhosis. We also showed that a new approach to network meta-analysis based on the technique of unrestricted weighted least squares (UWLS) method can also be undertaken using SEM. For both the fixed and random effect network meta-analysis, SEM yielded similar coefficients and confidence intervals to those reported in the previous literature. The point estimates of two UWLS models were identical to those in the fixed effect model but the confidence intervals were greater. This is consistent with results from the traditional pairwise meta-analyses. Comparing to UWLS model with common variance adjusted factor, UWLS model with unique variance adjusted factor has greater confidence intervals when the heterogeneity was larger in the pairwise comparison. The UWLS model with unique variance adjusted factor reflects the difference in heterogeneity within each comparison

Random error in cardiovascular meta-analyses

DEFF Research Database (Denmark)

Albalawi, Zaina; McAlister, Finlay A; Thorlund, Kristian

2013-01-01

BACKGROUND: Cochrane reviews are viewed as the gold standard in meta-analyses given their efforts to identify and limit systematic error which could cause spurious conclusions. The potential for random error to cause spurious conclusions in meta-analyses is less well appreciated. METHODS: We exam...

Prototyping SOS meta-theory in Maude

NARCIS (Netherlands)

Mousavi, M.R.; Reniers, M.A.; Mosses, P.D.; Ulidowski, I.

2006-01-01

We present a prototype implementation of SOS meta-theory in the Maude term rewriting language. The prototype defines the basic concepts of SOS meta-theory (e.g., transition formulae, deduction rules and transition system specifications) in Maude. Besides the basic definitions, we implement methods

Spatial effects in meta-foodwebs.

Science.gov (United States)

Barter, Edmund; Gross, Thilo

2017-08-30

In ecology it is widely recognised that many landscapes comprise a network of discrete patches of habitat. The species that inhabit the patches interact with each other through a foodweb, the network of feeding interactions. The meta-foodweb model proposed by Pillai et al. combines the feeding relationships at each patch with the dispersal of species between patches, such that the whole system is represented by a network of networks. Previous work on meta-foodwebs has focussed on landscape networks that do not have an explicit spatial embedding, but in real landscapes the patches are usually distributed in space. Here we compare the dispersal of a meta-foodweb on Erdős-Rényi networks, that do not have a spatial embedding, and random geometric networks, that do have a spatial embedding. We found that local structure and large network distances in spatially embedded networks, lead to meso-scale patterns of patch occupation by both specialist and omnivorous species. In particular, we found that spatial separations make the coexistence of competing species more likely. Our results highlight the effects of spatial embeddings for meta-foodweb models, and the need for new analytical approaches to them.

Diet influenced tooth erosion prevalence in children and adolescents: Results of a meta-analysis and meta-regression

NARCIS (Netherlands)

Salas, M.M.; Nascimento, G.G.; Vargas-Ferreira, F.; Tarquinio, S.B.; Huysmans, M.C.D.N.J.M.; Demarco, F.F.

2015-01-01

OBJECTIVE: The aim of the present study was to assess the influence of diet in tooth erosion presence in children and adolescents by meta-analysis and meta-regression. DATA: Two reviewers independently performed the selection process and the quality of studies was assessed. SOURCES: Studies

GWAMA: software for genome-wide association meta-analysis

Directory of Open Access Journals (Sweden)

Mägi Reedik

2010-05-01

Full Text Available Abstract Background Despite the recent success of genome-wide association studies in identifying novel loci contributing effects to complex human traits, such as type 2 diabetes and obesity, much of the genetic component of variation in these phenotypes remains unexplained. One way to improving power to detect further novel loci is through meta-analysis of studies from the same population, increasing the sample size over any individual study. Although statistical software analysis packages incorporate routines for meta-analysis, they are ill equipped to meet the challenges of the scale and complexity of data generated in genome-wide association studies. Results We have developed flexible, open-source software for the meta-analysis of genome-wide association studies. The software incorporates a variety of error trapping facilities, and provides a range of meta-analysis summary statistics. The software is distributed with scripts that allow simple formatting of files containing the results of each association study and generate graphical summaries of genome-wide meta-analysis results. Conclusions The GWAMA (Genome-Wide Association Meta-Analysis software has been developed to perform meta-analysis of summary statistics generated from genome-wide association studies of dichotomous phenotypes or quantitative traits. Software with source files, documentation and example data files are freely available online at http://www.well.ox.ac.uk/GWAMA.

MetaQTL: a package of new computational methods for the meta-analysis of QTL mapping experiments

Directory of Open Access Journals (Sweden)

Charcosset Alain

2007-02-01

Full Text Available Abstract Background Integration of multiple results from Quantitative Trait Loci (QTL studies is a key point to understand the genetic determinism of complex traits. Up to now many efforts have been made by public database developers to facilitate the storage, compilation and visualization of multiple QTL mapping experiment results. However, studying the congruency between these results still remains a complex task. Presently, the few computational and statistical frameworks to do so are mainly based on empirical methods (e.g. consensus genetic maps are generally built by iterative projection. Results In this article, we present a new computational and statistical package, called MetaQTL, for carrying out whole-genome meta-analysis of QTL mapping experiments. Contrary to existing methods, MetaQTL offers a complete statistical process to establish a consensus model for both the marker and the QTL positions on the whole genome. First, MetaQTL implements a new statistical approach to merge multiple distinct genetic maps into a single consensus map which is optimal in terms of weighted least squares and can be used to investigate recombination rate heterogeneity between studies. Secondly, assuming that QTL can be projected on the consensus map, MetaQTL offers a new clustering approach based on a Gaussian mixture model to decide how many QTL underly the distribution of the observed QTL. Conclusion We demonstrate using simulations that the usual model choice criteria from mixture model literature perform relatively well in this context. As expected, simulations also show that this new clustering algorithm leads to a reduction in the length of the confidence interval of QTL location provided that across studies there are enough observed QTL for each underlying true QTL location. The usefulness of our approach is illustrated on published QTL detection results of flowering time in maize. Finally, MetaQTL is freely available at http://bioinformatics.org/mqtl.

Bayesian Meta-Analysis of Coefficient Alpha

Science.gov (United States)

Brannick, Michael T.; Zhang, Nanhua

2013-01-01

The current paper describes and illustrates a Bayesian approach to the meta-analysis of coefficient alpha. Alpha is the most commonly used estimate of the reliability or consistency (freedom from measurement error) for educational and psychological measures. The conventional approach to meta-analysis uses inverse variance weights to combine…

Online Open Neuroimaging Mass Meta-Analysis with a Wiki

DEFF Research Database (Denmark)

Nielsen, Finn Arup; Kempton, Matthew J.; Williams, Steven C. R.

2015-01-01

We describe a system for meta-analysis where a wiki stores numerical data in a simple comma-separated values format and a web service performs the numerical statistical computation. We initially apply the system on multiple meta-analyses of structural neuroimaging data results. The described system...... allows for mass meta-analysis, e.g., meta-analysis across multiple brain regions and multiple mental disorders providing an overview of important relationships and their uncertainties in a collaborative environment....

Evaluation of Workflow Management Systems - A Meta Model Approach

Directory of Open Access Journals (Sweden)

Michael Rosemann

1998-11-01

Full Text Available The automated enactment of processes through the use of workflow management systems enables the outsourcing of the control flow from application systems. By now a large number of systems, that follow different workflow paradigms, are available. This leads to the problem of selecting the appropriate workflow management system for a given situation. In this paper we outline the benefits of a meta model approach for the evaluation and comparison of different workflow management systems. After a general introduction on the topic of meta modeling the meta models of the workflow management systems WorkParty (Siemens Nixdorf and FlowMark (IBM are compared as an example. These product specific meta models can be generalized to meta reference models, which helps to specify a workflow methodology. Exemplary, an organisational reference meta model is presented, which helps users in specifying their requirements for a workflow management system.

Meta-analytic framework for liquid association.

Science.gov (United States)

Wang, Lin; Liu, Silvia; Ding, Ying; Yuan, Shin-Sheng; Ho, Yen-Yi; Tseng, George C

2017-07-15

Although coexpression analysis via pair-wise expression correlation is popularly used to elucidate gene-gene interactions at the whole-genome scale, many complicated multi-gene regulations require more advanced detection methods. Liquid association (LA) is a powerful tool to detect the dynamic correlation of two gene variables depending on the expression level of a third variable (LA scouting gene). LA detection from single transcriptomic study, however, is often unstable and not generalizable due to cohort bias, biological variation and limited sample size. With the rapid development of microarray and NGS technology, LA analysis combining multiple gene expression studies can provide more accurate and stable results. In this article, we proposed two meta-analytic approaches for LA analysis (MetaLA and MetaMLA) to combine multiple transcriptomic studies. To compensate demanding computing, we also proposed a two-step fast screening algorithm for more efficient genome-wide screening: bootstrap filtering and sign filtering. We applied the methods to five Saccharomyces cerevisiae datasets related to environmental changes. The fast screening algorithm reduced 98% of running time. When compared with single study analysis, MetaLA and MetaMLA provided stronger detection signal and more consistent and stable results. The top triplets are highly enriched in fundamental biological processes related to environmental changes. Our method can help biologists understand underlying regulatory mechanisms under different environmental exposure or disease states. A MetaLA R package, data and code for this article are available at http://tsenglab.biostat.pitt.edu/software.htm. ctseng@pitt.edu. Supplementary data are available at Bioinformatics online. © The Author (2017). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

ResistoMap-online visualization of human gut microbiota antibiotic resistome.

Science.gov (United States)

Yarygin, Konstantin S; Kovarsky, Boris A; Bibikova, Tatyana S; Melnikov, Damir S; Tyakht, Alexander V; Alexeev, Dmitry G

2017-07-15

We created ResistoMap—a Web-based interactive visualization of the presence of genetic determinants conferring resistance to antibiotics, biocides and heavy metals in human gut microbiota. ResistoMap displays the data on more than 1500 published gut metagenomes of world populations including both healthy subjects and patients. Multiparameter display filters allow visual assessment of the associations between the meta-data and proportions of resistome. The geographic map navigation layer allows to state hypotheses regarding the global trends of antibiotic resistance and correlates the gut resistome variations with the national clinical guidelines on antibiotics application. ResistoMap was implemented using AngularJS, CoffeeScript, D3.js and TopoJSON. The tool is publicly available at http://resistomap.rcpcm.org. yarygin@phystech.edu. Supplementary data are available at Bioinformatics online. © The Author(s) 2017. Published by Oxford University Press.

Development of a Common Format of Questionnaire Tests for a Web-based Platform of Population and Experimental Psychological Research

Directory of Open Access Journals (Sweden)

Nikulchev Evgeny

2018-01-01

Full Text Available A web platform for psychological research needs a single format of questionnaire tests to ensure interaction between its components. The study proposes a general test structure, variant questions, variations in response types, and an embedded domain-specific language for computations. The use of JSON is proposed and justified to store the hierarchical structure of the questionnaire test, and JSON Schema is defined as a technology suitable for the formation of the standard. From the considered validation instruments for compliance with the standard described in JSON Schema, ajv was defined as the most applicable to the task. To build the documentation, Doca is relevant, but this tool needs to be modified to meet the requirements of the task.

Aplikasi Game Edukasi Membuat Canang Berbasis Android

Directory of Open Access Journals (Sweden)

Anak Agung Made Dian Krisnandari

2016-01-01

Full Text Available Game membuat canang merupakan suatu game edukasi yang dibuat untuk memperkenalkan canang pada umat Hindu, khususnya anak-anak. Game ini akan menampilkan berbagai macam canang yang digunakan pada kehidupan sehari-hari oleh umat Hindu. Game membuat canang berbasis mobile ini dibuat dengan menggunakan aplikasi Corona SDK. Corona didalam penggunakan aplikasinya menggunakan ekstensi data yang berbasis Lua, dimana Lua memiliki ekstensi data yang ringan dan mudah untuk dioprasikan sehingga sangat cocok digunakan untuk membuat game. Game edukasi ini juga memiliki perhitungan score yang dibuat dengan sangat sederhana dengan menggunakan basis data yang disebut JSON. JSON (JavaScript Object Notation merupakan format yang ringan untuk memasukan data ke dalam sebuah variabel.   Kata Kunci : game, canang, android, edukasi, Corona SDK, Lua, JSON

Evaluating the Quality of Evidence from a Network Meta-Analysis

Science.gov (United States)

Salanti, Georgia; Del Giovane, Cinzia; Chaimani, Anna; Caldwell, Deborah M.; Higgins, Julian P. T.

2014-01-01

Systematic reviews that collate data about the relative effects of multiple interventions via network meta-analysis are highly informative for decision-making purposes. A network meta-analysis provides two types of findings for a specific outcome: the relative treatment effect for all pairwise comparisons, and a ranking of the treatments. It is important to consider the confidence with which these two types of results can enable clinicians, policy makers and patients to make informed decisions. We propose an approach to determining confidence in the output of a network meta-analysis. Our proposed approach is based on methodology developed by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group for pairwise meta-analyses. The suggested framework for evaluating a network meta-analysis acknowledges (i) the key role of indirect comparisons (ii) the contributions of each piece of direct evidence to the network meta-analysis estimates of effect size; (iii) the importance of the transitivity assumption to the validity of network meta-analysis; and (iv) the possibility of disagreement between direct evidence and indirect evidence. We apply our proposed strategy to a systematic review comparing topical antibiotics without steroids for chronically discharging ears with underlying eardrum perforations. The proposed framework can be used to determine confidence in the results from a network meta-analysis. Judgements about evidence from a network meta-analysis can be different from those made about evidence from pairwise meta-analyses. PMID:24992266

Trial Sequential Methods for Meta-Analysis

Science.gov (United States)

Kulinskaya, Elena; Wood, John

2014-01-01

Statistical methods for sequential meta-analysis have applications also for the design of new trials. Existing methods are based on group sequential methods developed for single trials and start with the calculation of a required information size. This works satisfactorily within the framework of fixed effects meta-analysis, but conceptual…

Meta-analysis in microbiology

Directory of Open Access Journals (Sweden)

N Pabalan

2014-01-01

Full Text Available The use of meta-analysis in microbiology may facilitate decision-making that impacts public health policy. Directed at clinicians and researchers in microbiology, this review outlines the steps in performing this statistical technique, addresses its biases and describes its value in this discipline. The survey to estimate extent of the use of meta-analyses in microbiology shows the remarkable growth in the use of this research methodology, from a minimal Asian output to a level comparable with those of Europe and North America in the last 7 years.

Teknik Perangkingan Meta-search Engine

OpenAIRE

Puspitaningrum, Diyah

2014-01-01

Meta-search engine mengorganisasikan penyatuan hasil dari berbagai search engine dengan tujuan untuk meningkatkan presisi hasil pencarian dokumen web. Pada survei teknik perangkingan meta-search engine ini akan didiskusikan isu-isu pra-pemrosesan, rangking, dan berbagai teknik penggabungan hasil pencarian dari search engine yang berbeda-beda (multi-kombinasi). Isu-isu implementasi penggabungan 2 search engine dan 3 search engine juga menjadi sorotan. Pada makalah ini juga dibahas arahan penel...

Shadow-free multimers as extreme-performance meta-atoms

Science.gov (United States)

Safari, M.; Albooyeh, M.; Simovski, C. R.; Tretyakov, S. A.

2018-02-01

We generalize the concept of parity-time symmetric structures with the goal to create meta-atoms exhibiting extraordinary abilities to overcome the presumed limitations in the scattering of overall lossless particles, such as nonzero forward scattering and the equality of scattering and extinction powers for all lossless particles. Although the forward scattering amplitude and the extinction cross section of our proposed meta-atoms vanish, they scatter incident energy into other directions, with controllable directionality. These meta-atoms possess extreme electromagnetic properties not achievable for passive scatterers. As an example, we study meta-atoms consisting of two or three small dipole scatterers. We consider possible microwave realizations in the form of short dipole antennas loaded by lumped elements. The proposed meta-atom empowers extraordinary response of a shadow-free scatterer and theoretically enables most unusual material properties when used as a building block of an artificial medium.

Meta-Analysis in Stata Using Gllamm

Science.gov (United States)

Bagos, Pantelis G.

2015-01-01

There are several user-written programs for performing meta-analysis in Stata (Stata Statistical Software: College Station, TX: Stata Corp LP). These include metan, metareg, mvmeta, and glst. However, there are several cases for which these programs do not suffice. For instance, there is no software for performing univariate meta-analysis with…

Trial Sequential Analysis in systematic reviews with meta-analysis

DEFF Research Database (Denmark)

Wetterslev, Jørn; Jakobsen, Janus Christian; Gluud, Christian

2017-01-01

BACKGROUND: Most meta-analyses in systematic reviews, including Cochrane ones, do not have sufficient statistical power to detect or refute even large intervention effects. This is why a meta-analysis ought to be regarded as an interim analysis on its way towards a required information size...... from traditional meta-analyses using unadjusted naïve 95% confidence intervals and 5% thresholds for statistical significance. Spurious conclusions in systematic reviews with traditional meta-analyses can be reduced using Trial Sequential Analysis. Several empirical studies have demonstrated...

Development of a combined database for meta-epidemiological research

DEFF Research Database (Denmark)

Savović, Jelena; Harris, Ross J; Wood, Lesley

2010-01-01

or review. Unique identifiers were assigned to each reference and used to identify duplicate trials. Sets of meta-analyses with overlapping trials were identified and duplicates removed. Overlapping trials were used to examine agreement between assessments of trial characteristics. The combined database...... database will be used to examine the combined evidence on sources of bias in randomized controlled trials. The strategy used to remove overlap between meta-analyses may be of use for future empirical research. Copyright © 2010 John Wiley & Sons, Ltd.......Collections of meta-analyses assembled in meta-epidemiological studies are used to study associations of trial characteristics with intervention effect estimates. However, methods and findings are not consistent across studies. To combine data from 10 meta-epidemiological studies into a single...

Drivers of wetland conversion: a global meta-analysis.

Science.gov (United States)

van Asselen, Sanneke; Verburg, Peter H; Vermaat, Jan E; Janse, Jan H

2013-01-01

Meta-analysis of case studies has become an important tool for synthesizing case study findings in land change. Meta-analyses of deforestation, urbanization, desertification and change in shifting cultivation systems have been published. This present study adds to this literature, with an analysis of the proximate causes and underlying forces of wetland conversion at a global scale using two complementary approaches of systematic review. Firstly, a meta-analysis of 105 case-study papers describing wetland conversion was performed, showing that different combinations of multiple-factor proximate causes, and underlying forces, drive wetland conversion. Agricultural development has been the main proximate cause of wetland conversion, and economic growth and population density are the most frequently identified underlying forces. Secondly, to add a more quantitative component to the study, a logistic meta-regression analysis was performed to estimate the likelihood of wetland conversion worldwide, using globally-consistent biophysical and socioeconomic location factor maps. Significant factors explaining wetland conversion, in order of importance, are market influence, total wetland area (lower conversion probability), mean annual temperature and cropland or built-up area. The regression analyses results support the outcomes of the meta-analysis of the processes of conversion mentioned in the individual case studies. In other meta-analyses of land change, similar factors (e.g., agricultural development, population growth, market/economic factors) are also identified as important causes of various types of land change (e.g., deforestation, desertification). Meta-analysis helps to identify commonalities across the various local case studies and identify which variables may lead to individual cases to behave differently. The meta-regression provides maps indicating the likelihood of wetland conversion worldwide based on the location factors that have determined historic

Identifying null meta-analyses that are ripe for updating

Directory of Open Access Journals (Sweden)

Fang Manchun

2003-07-01

Full Text Available Abstract Background As an increasingly large number of meta-analyses are published, quantitative methods are needed to help clinicians and systematic review teams determine when meta-analyses are not up to date. Methods We propose new methods for determining when non-significant meta-analytic results might be overturned, based on a prediction of the number of participants required in new studies. To guide decision making, we introduce the "new participant ratio", the ratio of the actual number of participants in new studies to the predicted number required to obtain statistical significance. A simulation study was conducted to study the performance of our methods and a real meta-analysis provides further evidence. Results In our three simulation configurations, our diagnostic test for determining whether a meta-analysis is out of date had sensitivity of 55%, 62%, and 49% with corresponding specificity of 85%, 80%, and 90% respectively. Conclusions Simulations suggest that our methods are able to detect out-of-date meta-analyses. These quick and approximate methods show promise for use by systematic review teams to help decide whether to commit the considerable resources required to update a meta-analysis. Further investigation and evaluation of the methods is required before they can be recommended for general use.

Advances in meta-analysis: examples from internal medicine to neurology.

Science.gov (United States)

Copetti, Massimiliano; Fontana, Andrea; Graziano, Giusi; Veneziani, Federica; Siena, Federica; Scardapane, Marco; Lucisano, Giuseppe; Pellegrini, Fabio

2014-01-01

We review the state of the art in meta-analysis and data pooling following the evolution of the statistical models employed. Starting from a classic definition of meta-analysis of published data, a set of apparent antinomies which characterized the development of the meta-analytic tools are reconciled in dichotomies where the second term represents a possible generalization of the first one. Particular attention is given to the generalized linear mixed models as an overall framework for meta-analysis. Bayesian meta-analysis is discussed as a further possibility of generalization for sensitivity analysis and the use of priors as a data augmentation approach. We provide relevant examples to underline how the need for adequate methods to solve practical issues in specific areas of research have guided the development of advanced methods in meta-analysis. We show how all the advances in meta-analysis naturally merge into the unified framework of generalized linear mixed models and reconcile apparently conflicting approaches. All these complex models can be easily implemented with the standard commercial software available. © 2013 S. Karger AG, Basel.

Multivariate Methods for Meta-Analysis of Genetic Association Studies.

Science.gov (United States)

Dimou, Niki L; Pantavou, Katerina G; Braliou, Georgia G; Bagos, Pantelis G

2018-01-01

Multivariate meta-analysis of genetic association studies and genome-wide association studies has received a remarkable attention as it improves the precision of the analysis. Here, we review, summarize and present in a unified framework methods for multivariate meta-analysis of genetic association studies and genome-wide association studies. Starting with the statistical methods used for robust analysis and genetic model selection, we present in brief univariate methods for meta-analysis and we then scrutinize multivariate methodologies. Multivariate models of meta-analysis for a single gene-disease association studies, including models for haplotype association studies, multiple linked polymorphisms and multiple outcomes are discussed. The popular Mendelian randomization approach and special cases of meta-analysis addressing issues such as the assumption of the mode of inheritance, deviation from Hardy-Weinberg Equilibrium and gene-environment interactions are also presented. All available methods are enriched with practical applications and methodologies that could be developed in the future are discussed. Links for all available software implementing multivariate meta-analysis methods are also provided.

Dictator games: A meta study

OpenAIRE

Engel, Christoph

2010-01-01

Over the last 25 years, more than a hundred dictator game experiments have been published. This meta study summarizes the evidence. Exploiting the fact that most experiments had to fix parameters they did not intend to test, in multiple regression the meta study is able to assess the effect of single manipulations, controlling for a host of alternative explanatory factors. The resulting rich dataset also provides a testbed for comparing alternative specifications of the statistical model for ...

Estrategias de autorregulación del aprendizaje: contribución de la orientación de meta y la estructura de metas del aula

Directory of Open Access Journals (Sweden)

Martha Leticia GAETA GONZÁLEZ

2006-01-01

Full Text Available Los estudiantes autorregulados muestran habilidad para seleccionar y usar estrategias de aprendizaje acordes a las demandas de diferentes tareas. La orientación personal de los alumnos hacia una meta, así como su percepción de la estructura del aula, pueden contribuir en este sentido. Este trabajo analiza las relaciones entre la estructura de metas del aula, la orientación personal de meta y el uso de estrategias de control volitivo -motivacional y emocional- y de estrategias metacognitivas, en una muestra de alumnos (n=105 de Educación Secundaria Obligatoria (E.S.O., en centros públicos y concertados, mediante el auto-reporte. Los resultados indican que el adoptar una orientación de meta al aprendizaje, así como hacer uso de estrategias volitivas, predicen el uso de estrategias metacognitivas. Además, la estructura de metas orientada al aprendizaje influye indirectamente en esta relación, a través de la orientación de meta.

Cenp-meta is required for sustained spindle checkpoint

Directory of Open Access Journals (Sweden)

Thomas Rubin

2014-05-01

Full Text Available Cenp-E is a kinesin-like motor protein required for efficient end-on attachment of kinetochores to the spindle microtubules. Cenp-E immunodepletion in Xenopus mitotic extracts results in the loss of mitotic arrest and massive chromosome missegregation, whereas its depletion in mammalian cells leads to chromosome segregation defects despite the presence of a functional spindle assembly checkpoint (SAC. Cenp-meta has previously been reported to be the Drosophila homolog of vertebrate Cenp-E. In this study, we show that cenp-metaΔ mutant neuroblasts arrest in mitosis when treated with colchicine. cenp-metaΔ mutant cells display a mitotic delay. Yet, despite the persistence of the two checkpoint proteins Mad2 and BubR1 on unattached kinetochores, these cells eventually enter anaphase and give rise to highly aneuploid daughter cells. Indeed, we find that cenp-metaΔ mutant cells display a slow but continuous degradation of cyclin B, which eventually triggers the mitotic exit observed. Thus, our data provide evidence for a role of Cenp-meta in sustaining the SAC response.

Meta-Times and Extended Subordination

DEFF Research Database (Denmark)

Barndorff-Nielsen, Ole; Pedersen, Jan

The problem of defining subordination of a homogeneous Lévy basis by a non-negative homogeneous Lévy basis is discussed. An explicit construction, generalizing the usual one-dimensional case, is given. This construction involves certain random meta-time changes.......The problem of defining subordination of a homogeneous Lévy basis by a non-negative homogeneous Lévy basis is discussed. An explicit construction, generalizing the usual one-dimensional case, is given. This construction involves certain random meta-time changes....

Affective evolutionary music composition with MetaCompose

DEFF Research Database (Denmark)

Scirea, Marco; Togelius, Julian; Eklund, Peter

2017-01-01

This paper describes the MetaCompose music generator, a compositional, extensible framework for affective music composition. In this context ‘affective’ refers to the music generator’s ability to express emotional information. The main purpose of MetaCompose is to create music in real-time that can...

Metamaterial bricks and quantization of meta-surfaces

Science.gov (United States)

Memoli, Gianluca; Caleap, Mihai; Asakawa, Michihiro; Sahoo, Deepak R.; Drinkwater, Bruce W.; Subramanian, Sriram

2017-02-01

Controlling acoustic fields is crucial in diverse applications such as loudspeaker design, ultrasound imaging and therapy or acoustic particle manipulation. The current approaches use fixed lenses or expensive phased arrays. Here, using a process of analogue-to-digital conversion and wavelet decomposition, we develop the notion of quantal meta-surfaces. The quanta here are small, pre-manufactured three-dimensional units--which we call metamaterial bricks--each encoding a specific phase delay. These bricks can be assembled into meta-surfaces to generate any diffraction-limited acoustic field. We apply this methodology to show experimental examples of acoustic focusing, steering and, after stacking single meta-surfaces into layers, the more complex field of an acoustic tractor beam. We demonstrate experimentally single-sided air-borne acoustic levitation using meta-layers at various bit-rates: from a 4-bit uniform to 3-bit non-uniform quantization in phase. This powerful methodology dramatically simplifies the design of acoustic devices and provides a key-step towards realizing spatial sound modulators.

Meta-analysis in clinical trials revisited.

Science.gov (United States)

DerSimonian, Rebecca; Laird, Nan

2015-11-01

In this paper, we revisit a 1986 article we published in this Journal, Meta-Analysis in Clinical Trials, where we introduced a random-effects model to summarize the evidence about treatment efficacy from a number of related clinical trials. Because of its simplicity and ease of implementation, our approach has been widely used (with more than 12,000 citations to date) and the "DerSimonian and Laird method" is now often referred to as the 'standard approach' or a 'popular' method for meta-analysis in medical and clinical research. The method is especially useful for providing an overall effect estimate and for characterizing the heterogeneity of effects across a series of studies. Here, we review the background that led to the original 1986 article, briefly describe the random-effects approach for meta-analysis, explore its use in various settings and trends over time and recommend a refinement to the method using a robust variance estimator for testing overall effect. We conclude with a discussion of repurposing the method for Big Data meta-analysis and Genome Wide Association Studies for studying the importance of genetic variants in complex diseases. Published by Elsevier Inc.

Determinants of investment behaviour. Methods and applications of meta-analysis

International Nuclear Information System (INIS)

Koetse, M.J.

2006-01-01

Meta-analysis is gradually gaining ground in economics as a research method to objectively and quantitatively summarise a body of existing empirical evidence. This dissertation studies the performance of well-known meta-analytic models and presents two meta-analysis applications. Despite its many attractive features, meta-analysis faces several methodical difficulties, especially when applied in economic research. We investigate two specific methodical problems that any meta-analysis in economics will have to deal with, viz., systematic effect-size variation due to primary-study misspecifications, and random effect-size heterogeneity. Using Monte-Carlo analysis we investigate the effects of these methodical problems on the results of a meta-analysis, and study the small-sample properties of several well-known and often applied meta-estimators. The focus of the meta-analysis applications is on two topics that are relevant for understanding investment behaviour, viz., the impact of uncertainty on investment spending, and the potential for substitution of capital for energy in production processes. In the first application we aim to shed light on the direction of the relationship between investment and uncertainty, and to uncover which factors are empirically relevant for explaining the wide variety in study outcomes. In the second application our goal is to analyse the direction and magnitude of capital-energy substitution potential, and to analyse the empirical relevance of suggested sources of variation in elasticity estimates

Determinants of investment behaviour. Methods and applications of meta-analysis

Energy Technology Data Exchange (ETDEWEB)

Koetse, M.J.

2006-03-14

Meta-analysis is gradually gaining ground in economics as a research method to objectively and quantitatively summarise a body of existing empirical evidence. This dissertation studies the performance of well-known meta-analytic models and presents two meta-analysis applications. Despite its many attractive features, meta-analysis faces several methodical difficulties, especially when applied in economic research. We investigate two specific methodical problems that any meta-analysis in economics will have to deal with, viz., systematic effect-size variation due to primary-study misspecifications, and random effect-size heterogeneity. Using Monte-Carlo analysis we investigate the effects of these methodical problems on the results of a meta-analysis, and study the small-sample properties of several well-known and often applied meta-estimators. The focus of the meta-analysis applications is on two topics that are relevant for understanding investment behaviour, viz., the impact of uncertainty on investment spending, and the potential for substitution of capital for energy in production processes. In the first application we aim to shed light on the direction of the relationship between investment and uncertainty, and to uncover which factors are empirically relevant for explaining the wide variety in study outcomes. In the second application our goal is to analyse the direction and magnitude of capital-energy substitution potential, and to analyse the empirical relevance of suggested sources of variation in elasticity estimates.

Global Prevalence of Elder Abuse: A Meta-analysis and Meta-regression.

Science.gov (United States)

Ho, C Sh; Wong, S Y; Chiu, M M; Ho, R Cm

2017-06-01

Elder abuse is increasingly recognised as a global public health and social problem. There has been limited inter-study comparison of the prevalence and risk factors for elder abuse. This study aimed to estimate the pooled and subtype prevalence of elder abuse worldwide and identify significant associated risk factors. We conducted a meta-analysis and meta-regression of 34 population-based and 17 non-population-based studies. The pooled prevalences of elder abuse were 10.0% (95% confidence interval, 5.2%-18.6%) and 34.3% (95% confidence interval, 22.9%-47.8%) in population-based studies and third party- or caregiver-reported studies, respectively. Being in a marital relationship was found to be a significant moderator using random-effects model. This meta-analysis revealed that third parties or caregivers were more likely to report abuse than older abused adults. Subgroup analyses showed that females and those resident in non-western countries were more likely to be abused. Emotional abuse was the most prevalent elder abuse subtype and financial abuse was less commonly reported by third parties or caregivers. Heterogeneity in the prevalence was due to the high proportion of married older adults in the sample. Subgroup analysis showed that cultural factors, subtypes of abuse, and gender also contributed to heterogeneity in the pooled prevalence of elder abuse.

Systematic review and meta-analysis in cardiac surgery: a primer.

Science.gov (United States)

Yanagawa, Bobby; Tam, Derrick Y; Mazine, Amine; Tricco, Andrea C

2018-03-01

The purpose of this article is to review the strengths and weaknesses of systematic reviews and meta-analyses to inform our current understanding of cardiac surgery. A systematic review and meta-analysis of a focused topic can provide a quantitative estimate for the effect of a treatment intervention or exposure. In cardiac surgery, observational studies and small, single-center prospective trials provide most of the clinical outcomes that form the evidence base for patient management and guideline recommendations. As such, meta-analyses can be particularly valuable in synthesizing the literature for a particular focused surgical question. Since the year 2000, there are over 800 meta-analysis-related publications in our field. There are some limitations to this technique, including clinical, methodological and statistical heterogeneity, among other challenges. Despite these caveats, results of meta-analyses have been useful in forming treatment recommendations or in providing guidance in the design of future clinical trials. There is a growing number of meta-analyses in the field of cardiac surgery. Knowledge translation via meta-analyses will continue to guide and inform cardiac surgical practice and our practice guidelines.

Multivariate meta-analysis: Potential and promise

Science.gov (United States)

Jackson, Dan; Riley, Richard; White, Ian R

2011-01-01

The multivariate random effects model is a generalization of the standard univariate model. Multivariate meta-analysis is becoming more commonly used and the techniques and related computer software, although continually under development, are now in place. In order to raise awareness of the multivariate methods, and discuss their advantages and disadvantages, we organized a one day ‘Multivariate meta-analysis’ event at the Royal Statistical Society. In addition to disseminating the most recent developments, we also received an abundance of comments, concerns, insights, critiques and encouragement. This article provides a balanced account of the day's discourse. By giving others the opportunity to respond to our assessment, we hope to ensure that the various view points and opinions are aired before multivariate meta-analysis simply becomes another widely used de facto method without any proper consideration of it by the medical statistics community. We describe the areas of application that multivariate meta-analysis has found, the methods available, the difficulties typically encountered and the arguments for and against the multivariate methods, using four representative but contrasting examples. We conclude that the multivariate methods can be useful, and in particular can provide estimates with better statistical properties, but also that these benefits come at the price of making more assumptions which do not result in better inference in every case. Although there is evidence that multivariate meta-analysis has considerable potential, it must be even more carefully applied than its univariate counterpart in practice. Copyright © 2011 John Wiley & Sons, Ltd. PMID:21268052

Publication bias in dermatology systematic reviews and meta-analyses.

Science.gov (United States)

Atakpo, Paul; Vassar, Matt

2016-05-01

Systematic reviews and meta-analyses in dermatology provide high-level evidence for clinicians and policy makers that influence clinical decision making and treatment guidelines. One methodological problem with systematic reviews is the under representation of unpublished studies. This problem is due in part to publication bias. Omission of statistically non-significant data from meta-analyses may result in overestimation of treatment effect sizes which may lead to clinical consequences. Our goal was to assess whether systematic reviewers in dermatology evaluate and report publication bias. Further, we wanted to conduct our own evaluation of publication bias on meta-analyses that failed to do so. Our study considered systematic reviews and meta-analyses from ten dermatology journals from 2006 to 2016. A PubMed search was conducted, and all full-text articles that met our inclusion criteria were retrieved and coded by the primary author. 293 articles were included in our analysis. Additionally, we formally evaluated publication bias in meta-analyses that failed to do so using trim and fill and cumulative meta-analysis by precision methods. Publication bias was mentioned in 107 articles (36.5%) and was formally evaluated in 64 articles (21.8%). Visual inspection of a funnel plot was the most common method of evaluating publication bias. Publication bias was present in 45 articles (15.3%), not present in 57 articles (19.5%) and not determined in 191 articles (65.2%). Using the trim and fill method, 7 meta-analyses (33.33%) showed evidence of publication bias. Although the trim and fill method only found evidence of publication bias in 7 meta-analyses, the cumulative meta-analysis by precision method found evidence of publication bias in 15 meta-analyses (71.4%). Many of the reviews in our study did not mention or evaluate publication bias. Further, of the 42 articles that stated following PRISMA reporting guidelines, 19 (45.2%) evaluated for publication bias. In

Pd(II)-catalysed meta-C–H functionalizations of benzoic acid derivatives

Science.gov (United States)

Li, Shangda; Cai, Lei; Ji, Huafang; Yang, Long; Li, Gang

2016-01-01

Benzoic acids are highly important structural motifs in drug molecules and natural products. Selective C–H bond functionalization of benzoic acids will provide synthetically useful tools for step-economical organic synthesis. Although direct ortho-C–H functionalizations of benzoic acids or their derivatives have been intensely studied, the ability to activate meta-C–H bond of benzoic acids or their derivatives in a general manner via transition-metal catalysis has been largely unsuccessful. Although chelation-assisted meta-C–H functionalization of electron-rich arenes was reported, chelation-assisted meta-C–H activation of electron-poor arenes such as benzoic acid derivatives remains a formidable challenge. Herein, we report a general protocol for meta-C–H olefination of benzoic acid derivatives using a nitrile-based sulfonamide template. A broad range of benzoic acid derivatives are meta-selectively olefinated using molecular oxygen as the terminal oxidant. The meta-C–H acetoxylation, product of which is further transformed at the meta-position, is also reported. PMID:26813919

All-dielectric meta-holograms with holographic images transforming longitudinally

KAUST Repository

Wang, Qiu; Xu, Quan; Zhang, Xueqian; Tian, Chunxiu; Xu, Yuehong; Gu, Jianqiang; Tian, Zhen; Ouyang, Chunmei; Zhang, Xixiang; Han, Jiaguang; Zhang, Weili

2017-01-01

Metasurfaces are unique subwavelength geometries capable of engineering electromagnetic waves at will, delivering new opportunities for holography. Most previous meta-holograms, so-called phase-only meta-holograms, modulate only the amplitude distribution of a virtual object, and require optimizing techniques to improve the image quality. However, the phase distribution of the reconstructed image is usually overlooked in previous studies, leading to inevitable information loss. Here, we demonstrate all-dielectric meta-holograms that allow tailoring of both the phase and amplitude distributions of virtual objects. Several longitudinal manipulations of the holographic images are theoretically and experimentally demonstrated, including shifting, stretching, and rotating, enabling a large depth of focus. Furthermore, a new meta-hologram with a three-dimensional holographic design method is demonstrated with an even enhanced depth of focus. The proposed meta-holograms offer more freedom in holographic design and open new avenues for designing complex three-dimensional holography.

All-dielectric meta-holograms with holographic images transforming longitudinally

KAUST Repository

Wang, Qiu

2017-11-22

Metasurfaces are unique subwavelength geometries capable of engineering electromagnetic waves at will, delivering new opportunities for holography. Most previous meta-holograms, so-called phase-only meta-holograms, modulate only the amplitude distribution of a virtual object, and require optimizing techniques to improve the image quality. However, the phase distribution of the reconstructed image is usually overlooked in previous studies, leading to inevitable information loss. Here, we demonstrate all-dielectric meta-holograms that allow tailoring of both the phase and amplitude distributions of virtual objects. Several longitudinal manipulations of the holographic images are theoretically and experimentally demonstrated, including shifting, stretching, and rotating, enabling a large depth of focus. Furthermore, a new meta-hologram with a three-dimensional holographic design method is demonstrated with an even enhanced depth of focus. The proposed meta-holograms offer more freedom in holographic design and open new avenues for designing complex three-dimensional holography.

Systematic review with meta-analysis

DEFF Research Database (Denmark)

Kimer, N; Krag, A; Møller, Søren

2014-01-01

BACKGROUND: Rifaximin is recommended for prevention of hepatic encephalopathy (HE). The effects of rifaximin on overt and minimal HE are debated. AIM: To perform a systematic review and meta-analysis of randomised controlled trials (RCTs) on rifaximin for HE. METHODS: We performed electronic...... and manual searches, gathered information from the U.S. Food and Drug Administration Home Page, and obtained unpublished information on trial design and outcome measures from authors and pharmaceutical companies. Meta-analyses were performed and results presented as risk ratios (RR) with 95% confidence...

a meta-analysis

Indian Academy of Sciences (India)

Chrissa G. Tsiara

2018-03-13

Mar 13, 2018 ... a meta-analysis of case–control studies was conducted. Univariate and ...... recent hepatitis C virus: potential benefit for ribavirin use in. HCV/HIV ... C/G polymorphism in breast pathologies and in HIV-infected patients.

Escala de Metas de Estudio para Estudiantes Universitarios

Directory of Open Access Journals (Sweden)

María Victoria Pérez Villalobos

2009-01-01

Full Text Available Actualmente disponemos de gran cantidad de trabajos que muestran la implicación de las metas de estudio en la motivación por estudiar y aprender. Este trabajo analiza la motivación académica y, especialmente, la variable "metas de estudio". El principal propósito de esta investigación es conocer las características psicométricas de la adaptación de la Escala de Metas de Estudio a la población universitaria chilena. Los participantes son 542 estudiantes chilenos, de distintas facultades universitarias. Los resultados del análisis factorial y de consistencia interna son aceptables en las tres subescalas. Estos resultados fundamentan el uso de la Escala de Metas de Estudio para evaluar la motivación al estudio de alumnas y alumnos universitarios en Chile (CL.

Elastic wave manipulation by using a phase-controlling meta-layer

Science.gov (United States)

Shen, Xiaohui; Sun, Chin-Teh; Barnhart, Miles V.; Huang, Guoliang

2018-03-01

In this work, a high pass meta-layer for elastic waves is proposed. An elastic phase-controlling meta-layer is theoretically realized using parallel and periodically arranged metamaterial sections based on the generalized Snell's law. The elastic meta-layer is composed of periodically repeated supercells, in which the frequency dependent elastic properties of the metamaterial are used to control a phase gradient at the interface between the meta-layer and conventional medium. It is analytically and numerically demonstrated that with a normal incident longitudinal wave, the wave propagation characteristics can be directly manipulated by the periodic length of the meta-layer element at the sub-wavelength scale. It is found that propagation of the incident wave through the interface is dependent on whether the working wavelength is longer or shorter than the periodic length of the meta-layer element. Specifically, a mode conversion of the P-wave to an SV-wave is investigated as the incident wave passes through the meta-layer region. Since the most common and damaging elastic waves in civil and mechanical industries are in the low frequency region, the work in this paper has great potential in the seismic shielding, engine vibration isolation, and other highly dynamic fields.

MetaPhinder-Identifying Bacteriophage Sequences in Metagenomic Data Sets

DEFF Research Database (Denmark)

Jurtz, Vanessa Isabell; Villarroel, Julia; Lund, Ole

2016-01-01

genome structure of many bacteriophages. The method is demonstrated to outperform both BLAST methods based on single hits and methods based on k-mer comparisons. MetaPhinder is available as a web service at the Center for Genomic Epidemiology https://cge.cbs.dtu.dk/services/MetaPhinder/, while the source...... and understand them. Here we present MetaPhinder, a method to identify assembled genomic fragments (i.e. contigs) of phage origin in metage-nomic data sets. The method is based on a comparison to a database of whole genome bacteriophage sequences, integrating hits to multiple genomes to accomodate for the mosaic...... code can be downloaded from https://bitbucket.org/genomicepidemiology/metaphinder or https://github.com/vanessajurtz/MetaPhinder....

Mechanical meta-materials

NARCIS (Netherlands)

Zadpoor, A.A.

2016-01-01

The emerging concept of mechanical meta-materials has received increasing attention during the last few years partially due to the advances in additive manufacturing techniques that have enabled fabricating materials with arbitrarily complex micro/nano-architectures. The rationally designed

Strong coupling effects between a meta-atom and MIM nanocavity

Directory of Open Access Journals (Sweden)

San Chen

2012-09-01

Full Text Available In this paper, we investigate the strong coupling effects between a meta-atom and a metal-insulator-metal (MIM nanocavity. By changing the meta-atom sizes, we achieve the meta-atomic electric dipole, quadrupole or multipole interaction with the plasmonic nanocavity, in which characteristic anticrossing behaviors demonstrate the occurrence of the strong coupling. The various interactions present obviously different splitting values and behaviors of dependence on the meta-atomic position. The largest Rabi-type splittings, about 360.0 meV and 306.1 meV, have been obtained for electric dipole and quadrupole interaction, respectively. We attribute the large splitting to the highly-confined cavity mode and the large transition dipole of the meta-atom. Also the Rabi-type oscillation in time domain is given.

Women's meta-perceptions of attractiveness and their relations to body image.

Science.gov (United States)

Dijkstra, Pieternel; Barelds, Dick P H

2011-01-01

The present study examined meta-perceptions of attractiveness among women. More specifically, ratings were collected about how women thought their partner, family and friends, and strangers would view their physical attractiveness. In an online survey, 1287 Dutch women (aged 19-80 years) answered questions concerning meta-perceptions of attractiveness, demographic data, body mass index (BMI), body image (Body Areas Satisfaction Scale, self-rated general physical attractiveness, and actual-ideal weight discrepancy), and self-esteem. Results showed that women's meta-perceptions of attractiveness reflected the level of closeness of the relationship with the other person, with the most positive meta-perceptions reported for the partner, followed by those for family and friends, and the least positive meta-perceptions for strangers. Meta-perceptions were strongly related to body image, self-esteem and BMI. Self-ratings of attractiveness appeared to be lower than all meta-perceptions of attractiveness, suggesting that women are aware of their own negative self-bias and/or other people's positive bias. Copyright © 2010 Elsevier Ltd. All rights reserved.

Network meta-analysis-highly attractive but more methodological research is needed

Directory of Open Access Journals (Sweden)

Singh Sonal

2011-06-01

Full Text Available Abstract Network meta-analysis, in the context of a systematic review, is a meta-analysis in which multiple treatments (that is, three or more are being compared using both direct comparisons of interventions within randomized controlled trials and indirect comparisons across trials based on a common comparator. To ensure validity of findings from network meta-analyses, the systematic review must be designed rigorously and conducted carefully. Aspects of designing and conducting a systematic review for network meta-analysis include defining the review question, specifying eligibility criteria, searching for and selecting studies, assessing risk of bias and quality of evidence, conducting a network meta-analysis, interpreting and reporting findings. This commentary summarizes the methodologic challenges and research opportunities for network meta-analysis relevant to each aspect of the systematic review process based on discussions at a network meta-analysis methodology meeting we hosted in May 2010 at the Johns Hopkins Bloomberg School of Public Health. Since this commentary reflects the discussion at that meeting, it is not intended to provide an overview of the field.

The end of meta search engines in Europe?

NARCIS (Netherlands)

Husovec, Martin

2015-01-01

The technology behind the meta search engines supports countless number of Internet services ranging from the price and quality comparison websites to more sophisticated traffic connection finders and general search engines like Google. Meta search engines generally increase market transparency,

Conducting Meta-Analyses Based on p Values

Science.gov (United States)

van Aert, Robbie C. M.; Wicherts, Jelte M.; van Assen, Marcel A. L. M.

2016-01-01

Because of overwhelming evidence of publication bias in psychology, techniques to correct meta-analytic estimates for such bias are greatly needed. The methodology on which the p-uniform and p-curve methods are based has great promise for providing accurate meta-analytic estimates in the presence of publication bias. However, in this article, we show that in some situations, p-curve behaves erratically, whereas p-uniform may yield implausible estimates of negative effect size. Moreover, we show that (and explain why) p-curve and p-uniform result in overestimation of effect size under moderate-to-large heterogeneity and may yield unpredictable bias when researchers employ p-hacking. We offer hands-on recommendations on applying and interpreting results of meta-analyses in general and p-uniform and p-curve in particular. Both methods as well as traditional methods are applied to a meta-analysis on the effect of weight on judgments of importance. We offer guidance for applying p-uniform or p-curve using R and a user-friendly web application for applying p-uniform. PMID:27694466

Meta-analysis of individual registry results enhances international registry collaboration.

Science.gov (United States)

Paxton, Elizabeth W; Mohaddes, Maziar; Laaksonen, Inari; Lorimer, Michelle; Graves, Stephen E; Malchau, Henrik; Namba, Robert S; Kärrholm, John; Rolfson, Ola; Cafri, Guy

2018-03-28

Background and purpose - Although common in medical research, meta-analysis has not been widely adopted in registry collaborations. A meta-analytic approach in which each registry conducts a standardized analysis on its own data followed by a meta-analysis to calculate a weighted average of the estimates allows collaboration without sharing patient-level data. The value of meta-analysis as an alternative to individual patient data analysis is illustrated in this study by comparing the risk of revision of porous tantalum cups versus other uncemented cups in primary total hip arthroplasties from Sweden, Australia, and a US registry (2003-2015). Patients and methods - For both individual patient data analysis and meta-analysis approaches a Cox proportional hazard model was fit for time to revision, comparing porous tantalum (n = 23,201) with other uncemented cups (n = 128,321). Covariates included age, sex, diagnosis, head size, and stem fixation. In the meta-analysis approach, treatment effect size (i.e., Cox model hazard ratio) was calculated within each registry and a weighted average for the individual registries' estimates was calculated. Results - Patient-level data analysis and meta-analytic approaches yielded the same results with the porous tantalum cups having a higher risk of revision than other uncemented cups (HR (95% CI) 1.6 (1.4-1.7) and HR (95% CI) 1.5 (1.4-1.7), respectively). Adding the US cohort to the meta-analysis led to greater generalizability, increased precision of the treatment effect, and similar findings (HR (95% CI) 1.6 (1.4-1.7)) with increased risk of porous tantalum cups. Interpretation - The meta-analytic technique is a viable option to address privacy, security, and data ownership concerns allowing more expansive registry collaboration, greater generalizability, and increased precision of treatment effects.

A meta-model for computer executable dynamic clinical safety checklists.

Science.gov (United States)

Nan, Shan; Van Gorp, Pieter; Lu, Xudong; Kaymak, Uzay; Korsten, Hendrikus; Vdovjak, Richard; Duan, Huilong

2017-12-12

Safety checklist is a type of cognitive tool enforcing short term memory of medical workers with the purpose of reducing medical errors caused by overlook and ignorance. To facilitate the daily use of safety checklists, computerized systems embedded in the clinical workflow and adapted to patient-context are increasingly developed. However, the current hard-coded approach of implementing checklists in these systems increase the cognitive efforts of clinical experts and coding efforts for informaticists. This is due to the lack of a formal representation format that is both understandable by clinical experts and executable by computer programs. We developed a dynamic checklist meta-model with a three-step approach. Dynamic checklist modeling requirements were extracted by performing a domain analysis. Then, existing modeling approaches and tools were investigated with the purpose of reusing these languages. Finally, the meta-model was developed by eliciting domain concepts and their hierarchies. The feasibility of using the meta-model was validated by two case studies. The meta-model was mapped to specific modeling languages according to the requirements of hospitals. Using the proposed meta-model, a comprehensive coronary artery bypass graft peri-operative checklist set and a percutaneous coronary intervention peri-operative checklist set have been developed in a Dutch hospital and a Chinese hospital, respectively. The result shows that it is feasible to use the meta-model to facilitate the modeling and execution of dynamic checklists. We proposed a novel meta-model for the dynamic checklist with the purpose of facilitating creating dynamic checklists. The meta-model is a framework of reusing existing modeling languages and tools to model dynamic checklists. The feasibility of using the meta-model is validated by implementing a use case in the system.

Dynamical SUSY breaking in meta-stable vacua

International Nuclear Information System (INIS)

Intriligator, Kenneth; Seiberg, Nathan; Shih, David

2006-01-01

Dynamical supersymmetry breaking in a long-lived meta-stable vacuum is a phenomenologically viable possibility. This relatively unexplored avenue leads to many new models of dynamical supersymmetry breaking. Here, we present a surprisingly simple class of models with meta-stable dynamical supersymmetry breaking: N = 1 supersymmetric QCD, with massive flavors. Though these theories are strongly coupled, we definitively demonstrate the existence of meta-stable vacua by using the free-magnetic dual. Model building challenges, such as large flavor symmetries and the absence of an R-symmetry, are easily accommodated in these theories. Their simplicity also suggests that broken supersymmetry is generic in supersymmetric field theory and in the landscape of string vacua

META-COMMUNICATION FOR REFLECTIVE ONLINE CONVERSATIONS: Models for Distance Education

Directory of Open Access Journals (Sweden)

Yasin OZARSLAN

2012-01-01

Full Text Available “Meta Communication” is the process between message designers when they are talking about the learning process, as distinguished from their articulation of the “substantive” learning, itself. Therefore, it is important to understand how to design reflective online conversations and how to implement a diverse milieu for prospective online learners so that they are able to transfer their information, knowledge, and learning from theoretical forms to real life experiences. This book discusses meta-communication for reflective online conversations to provide digital people with models for distance education. This book brings together meta-communication, distance education, and models as well as reflective online conversations at the same time.The book is consisted of 321 pages covering 17 chapters. Topics covered in this book are divided into four sections: Meta-communicative knowledge building and online communications, dynamic models of meta-communication and reflective conversations, designing online messages for reflections, and meta-communicative assessments and reflective communication skills. The book's broader audience is anyone who is involved in e-learning.

The SQL++ Query Language: Configurable, Unifying and Semi-structured

OpenAIRE

Ong, Kian Win; Papakonstantinou, Yannis; Vernoux, Romain

2014-01-01

NoSQL databases support semi-structured data, typically modeled as JSON. They also provide limited (but expanding) query languages. Their idiomatic, non-SQL language constructs, the many variations, and the lack of formal semantics inhibit deep understanding of the query languages, and also impede progress towards clean, powerful, declarative query languages. This paper specifies the syntax and semantics of SQL++, which is applicable to both JSON native stores and SQL databases. The SQL++ sem...

Meta Search Engines.

Science.gov (United States)

Garman, Nancy

1999-01-01

Describes common options and features to consider in evaluating which meta search engine will best meet a searcher's needs. Discusses number and names of engines searched; other sources and specialty engines; search queries; other search options; and results options. (AEF)

Meta-analyses triggered by previous (false-)significant findings : Problems and solutions

NARCIS (Netherlands)

Schuit, Ewoud; Roes, Kit C B; Mol, Ben W J; Kwee, Anneke; Moons, Karel G M; Groenwold, Rolf H H

2015-01-01

BACKGROUND: Meta-analyses are typically triggered by a (potentially false-significant) finding in one of the preceding primary studies. We studied consequences of meta-analysis investigating effects when primary studies that triggered such meta-analysis are also included. METHODS: We analytically

The more total cognitive load is reduced by cues, the better retention and transfer of multimedia learning: A meta-analysis and two meta-regression analyses.

Science.gov (United States)

Xie, Heping; Wang, Fuxing; Hao, Yanbin; Chen, Jiaxue; An, Jing; Wang, Yuxin; Liu, Huashan

2017-01-01

Cueing facilitates retention and transfer of multimedia learning. From the perspective of cognitive load theory (CLT), cueing has a positive effect on learning outcomes because of the reduction in total cognitive load and avoidance of cognitive overload. However, this has not been systematically evaluated. Moreover, what remains ambiguous is the direct relationship between the cue-related cognitive load and learning outcomes. A meta-analysis and two subsequent meta-regression analyses were conducted to explore these issues. Subjective total cognitive load (SCL) and scores on a retention test and transfer test were selected as dependent variables. Through a systematic literature search, 32 eligible articles encompassing 3,597 participants were included in the SCL-related meta-analysis. Among them, 25 articles containing 2,910 participants were included in the retention-related meta-analysis and the following retention-related meta-regression, while there were 29 articles containing 3,204 participants included in the transfer-related meta-analysis and the transfer-related meta-regression. The meta-analysis revealed a statistically significant cueing effect on subjective ratings of cognitive load (d = -0.11, 95% CI = [-0.19, -0.02], p < 0.05), retention performance (d = 0.27, 95% CI = [0.08, 0.46], p < 0.01), and transfer performance (d = 0.34, 95% CI = [0.12, 0.56], p < 0.01). The subsequent meta-regression analyses showed that dSCL for cueing significantly predicted dretention for cueing (β = -0.70, 95% CI = [-1.02, -0.38], p < 0.001), as well as dtransfer for cueing (β = -0.60, 95% CI = [-0.92, -0.28], p < 0.001). Thus in line with CLT, adding cues in multimedia materials can indeed reduce SCL and promote learning outcomes, and the more SCL is reduced by cues, the better retention and transfer of multimedia learning.

Drivers of Wetland Conversion: a Global Meta-Analysis

NARCIS (Netherlands)

van Asselen, S.; Verburg, P.H.; Vermaat, J.E.; Janse, J.

2013-01-01

Meta-analysis of case studies has become an important tool for synthesizing case study findings in land change. Meta-analyses of deforestation, urbanization, desertification and change in shifting cultivation systems have been published. This present study adds to this literature, with an analysis

Detonation of Meta-stable Clusters

Energy Technology Data Exchange (ETDEWEB)

Kuhl, Allen; Kuhl, Allen L.; Fried, Laurence E.; Howard, W. Michael; Seizew, Michael R.; Bell, John B.; Beckner, Vincent; Grcar, Joseph F.

2008-05-31

We consider the energy accumulation in meta-stable clusters. This energy can be much larger than the typical chemical bond energy (~;;1 ev/atom). For example, polymeric nitrogen can accumulate 4 ev/atom in the N8 (fcc) structure, while helium can accumulate 9 ev/atom in the excited triplet state He2* . They release their energy by cluster fission: N8 -> 4N2 and He2* -> 2He. We study the locus of states in thermodynamic state space for the detonation of such meta-stable clusters. In particular, the equilibrium isentrope, starting at the Chapman-Jouguet state, and expanding down to 1 atmosphere was calculated with the Cheetah code. Large detonation pressures (3 and 16 Mbar), temperatures (12 and 34 kilo-K) and velocities (20 and 43 km/s) are a consequence of the large heats of detonation (6.6 and 50 kilo-cal/g) for nitrogen and helium clusters respectively. If such meta-stable clusters could be synthesized, they offer the potential for large increases in the energy density of materials.

A methodological systematic review of what's wrong with meta-ethnography reporting.

Science.gov (United States)

France, Emma F; Ring, Nicola; Thomas, Rebecca; Noyes, Jane; Maxwell, Margaret; Jepson, Ruth

2014-11-19

Syntheses of qualitative studies can inform health policy, services and our understanding of patient experience. Meta-ethnography is a systematic seven-phase interpretive qualitative synthesis approach well-suited to producing new theories and conceptual models. However, there are concerns about the quality of meta-ethnography reporting, particularly the analysis and synthesis processes. Our aim was to investigate the application and reporting of methods in recent meta-ethnography journal papers, focusing on the analysis and synthesis process and output. Methodological systematic review of health-related meta-ethnography journal papers published from 2012-2013. We searched six electronic databases, Google Scholar and Zetoc for papers using key terms including 'meta-ethnography.' Two authors independently screened papers by title and abstract with 100% agreement. We identified 32 relevant papers. Three authors independently extracted data and all authors analysed the application and reporting of methods using content analysis. Meta-ethnography was applied in diverse ways, sometimes inappropriately. In 13% of papers the approach did not suit the research aim. In 66% of papers reviewers did not follow the principles of meta-ethnography. The analytical and synthesis processes were poorly reported overall. In only 31% of papers reviewers clearly described how they analysed conceptual data from primary studies (phase 5, 'translation' of studies) and in only one paper (3%) reviewers explicitly described how they conducted the analytic synthesis process (phase 6). In 38% of papers we could not ascertain if reviewers had achieved any new interpretation of primary studies. In over 30% of papers seminal methodological texts which could have informed methods were not cited. We believe this is the first in-depth methodological systematic review of meta-ethnography conduct and reporting. Meta-ethnography is an evolving approach. Current reporting of methods, analysis and

Tuning the hybridization bandgap by meta-molecules with in-unit interaction

Energy Technology Data Exchange (ETDEWEB)

Chen, Yongqiang; Li, Yunhui, E-mail: liyunhui@tongji.edu.cn; Wu, Qian; Jiang, Haitao; Zhang, Yewen; Chen, Hong [Key Laboratory of Advanced Micro-Structured Materials, Ministry of Education, School of Physics Science and Engineering, Tongji University, Shanghai 200092 (China)

2015-09-07

In this paper, we demonstrate that the hybridization bandgap (HBG) can be tuned conveniently by deep subwavelength meta-molecules with in-unit interaction. Spontaneous-emission-cancellation-like (SEC-like) effect is realized in a meta-molecule by introducing the destructive interference of two detuned meta-atoms. The meta-atoms consisting of subwavelength zero-index-metamaterial-based resonators are side-coupled to a microstrip. Compared to conventional HBG configurations, the presence of in-unit interaction between meta-atoms provides more flexibility in tuning the bandgap properties, keeping the device volume almost unchanged. Both numerical simulations and microwave experiments confirm that the width, depth, and spectrum shape of HBG can be tuned by simply introducing SEC-like interaction into the meta-molecule. Due to these features, our design may be promising to be applied in microwave or optics communications systems with strict limitation of device volume and flexible bandgap properties.

MetaBAT: Metagenome Binning based on Abundance and Tetranucleotide frequence

Energy Technology Data Exchange (ETDEWEB)

Kang, Dongwan; Froula, Jeff; Egan, Rob; Wang, Zhong

2014-03-21

Grouping large fragments assembled from shotgun metagenomic sequences to deconvolute complex microbial communities, or metagenome binning, enables the study of individual organisms and their interactions. Here we developed automated metagenome binning software, called MetaBAT, which integrates empirical probabilistic distances of genome abundance and tetranucleotide frequency. On synthetic datasets MetaBAT on average achieves 98percent precision and 90percent recall at the strain level with 281 near complete unique genomes. Applying MetaBAT to a human gut microbiome data set we recovered 176 genome bins with 92percent precision and 80percent recall. Further analyses suggest MetaBAT is able to recover genome fragments missed in reference genomes up to 19percent, while 53 genome bins are novel. In summary, we believe MetaBAT is a powerful tool to facilitate comprehensive understanding of complex microbial communities.

Prevalence of rapid eye movement sleep behavior disorder (RBD) in Parkinson's disease: a meta and meta-regression analysis.

Science.gov (United States)

Zhang, Xiaona; Sun, Xiaoxuan; Wang, Junhong; Tang, Liou; Xie, Anmu

2017-01-01

Rapid eye movement sleep behavior disorder (RBD) is thought to be one of the most frequent preceding symptoms of Parkinson's disease (PD). However, the prevalence of RBD in PD stated in the published studies is still inconsistent. We conducted a meta and meta-regression analysis in this paper to estimate the pooled prevalence. We searched the electronic databases of PubMed, ScienceDirect, EMBASE and EBSCO up to June 2016 for related articles. STATA 12.0 statistics software was used to calculate the available data from each research. The prevalence of RBD in PD patients in each study was combined to a pooled prevalence with a 95 % confidence interval (CI). Subgroup analysis and meta-regression analysis were performed to search for the causes of the heterogeneity. A total of 28 studies with 6869 PD cases were deemed eligible and included in our meta-analysis based on the inclusion and exclusion criteria. The pooled prevalence of RBD in PD was 42.3 % (95 % CI 37.4-47.1 %). In subgroup analysis and meta-regression analysis, we found that the important causes of heterogeneity were the diagnosis criteria of RBD and age of PD patients (P = 0.016, P = 0.019, respectively). The results indicate that nearly half of the PD patients are suffering from RBD. Older age and longer duration are risk factors for RBD in PD. We can use the minimal diagnosis criteria for RBD according to the International Classification of Sleep Disorders to diagnose RBD patients in our daily work if polysomnography is not necessary.

Simpson's paradox visualized: The example of the Rosiglitazone meta-analysis

Directory of Open Access Journals (Sweden)

Schumacher Martin

2008-05-01

Full Text Available Abstract Background Simpson's paradox is sometimes referred to in the areas of epidemiology and clinical research. It can also be found in meta-analysis of randomized clinical trials. However, though readers are able to recalculate examples from hypothetical as well as real data, they may have problems to easily figure where it emerges from. Method First, two kinds of plots are proposed to illustrate the phenomenon graphically, a scatter plot and a line graph. Subsequently, these can be overlaid, resulting in a overlay plot. The plots are applied to the recent large meta-analysis of adverse effects of rosiglitazone on myocardial infarction and to an example from the literature. A large set of meta-analyses is screened for further examples. Results As noted earlier by others, occurrence of Simpson's paradox in the meta-analytic setting, if present, is associated with imbalance of treatment arm size. This is well illustrated by the proposed plots. The rosiglitazone meta-analysis shows an effect reversion if all trials are pooled. In a sample of 157 meta-analyses, nine showed an effect reversion after pooling, though non-significant in all cases. Conclusion The plots give insight on how the imbalance of trial arm size works as a confounder, thus producing Simpson's paradox. Readers can see why meta-analytic methods must be used and what is wrong with simple pooling.

Angry Birds, Angry Children, and Angry Meta-Analysts: A Reanalysis.

Science.gov (United States)

Furuya-Kanamori, Luis; Doi, Suhail A R

2016-05-01

Ferguson's (2015a) meta-analysis assessed a very important and controversial topic about children's mental health and video games. In response to the concerns raised by researchers about the appropriateness of the meta-analytical methods used by Ferguson; we decided to reanalyze the data and discuss two major misconceptions about meta-analysis. We argue that partial correlations can (and should) be meta-analyzed instead of zero-order bivariate correlations if the predictors included in the partial correlation represent a similar construct. We also discuss the fallacy by which the conventional meta-analytical model assumes that the studies' effect sizes came into being according to the same random effect construct used by the analysis. Our replication results using partial correlations, standardized (valid and reliable) outcomes, and an improved meta-analytical model (that does not assume a random effect is the mechanism of data generation) confirmed the main results of Ferguson's meta-analysis. There was a significant yet very small effect on aggressive behavior of exposure to both general, rp = 0.062, 95% CI [0.012, 0.112], and violent, rp = 0.055, 95% CI [0.019, 0.091], video games. A very small effect was seen on reduced prosocial behavior, but this was only in the general video game exposure category, rp = 0.072, 95% CI [0.045, 0.100]. © The Author(s) 2016.

The politics of meta-governance in transnational private sustainability governance

OpenAIRE

Fransen, L.

2015-01-01

In order to address challenges resulting from interactions between transnational private sustainability standard organizations, initiatives emerge that meta-govern these standards. Contrary to prevailing understandings in public policy literature, such meta-governance initiatives are mostly run by nongovernmental rather than governmental actors. While literature presents the sustainability standards field as predominantly governed by one meta-governor, ISEAL, it is hardly recognized that, alo...

The metacompiler system META-II/X

International Nuclear Information System (INIS)

Kneis, W.

1975-03-01

It is the objective of this work to demonstrate by the properties of the META-II/X system and concrete compiler implementation for IML that a simple and universally applicable symbol processor allows to develop in a very easy manner precompilers for problem oriented languages. The main feature consists in the fact that no auxiliary routines coded manually had to be added for special implementation. The translation of IML is exclusively defined by the compiler description written in the META language. As a whole, META-II/X proves to be a system which is relatively convenient to handle in automating the translation of explicit languages. The decisive point is the choise of an assembler language as target language allowing to transfer to the assembler level references not completely resolved. Implementation includes the possibility of an uncomplicated transfer of the whole system inclusive of the internal compiler representations. (orig.) [de

Why, when and how to update a meta-ethnography qualitative synthesis.

Science.gov (United States)

France, Emma F; Wells, Mary; Lang, Heidi; Williams, Brian

2016-03-15

Meta-ethnography is a unique, systematic, qualitative synthesis approach widely used to provide robust evidence on patient and clinician beliefs and experiences and understandings of complex social phenomena. It can make important theoretical and conceptual contributions to health care policy and practice. Since beliefs, experiences, health care contexts and social phenomena change over time, the continued relevance of the findings from meta-ethnographies cannot be assumed. However, there is little guidance on whether, when and how meta-ethnographies should be updated; Cochrane guidance on updating reviews of intervention effectiveness is unlikely to be fully appropriate. This is the first in-depth discussion on updating a meta-ethnography; it explores why, when and how to update a meta-ethnography. Three main methods of updating the analysis and synthesis are examined. Advantages and disadvantages of each method are outlined, relating to the context, purpose, process and output of the update and the nature of the new data available. Recommendations are made for the appropriate use of each method, and a worked example of updating a meta-ethnography is provided. This article makes a unique contribution to this evolving area of meta-ethnography methodology.

Meta-Analytical Studies in Transport Economics. Methodology and Applications

Energy Technology Data Exchange (ETDEWEB)

Brons, M.R.E.

2006-05-18

Vast increases in the external costs of transport in the late twentieth century have caused national and international governmental bodies to worry about the sustainability of their transport systems. In this thesis we use meta-analysis as a research method to study various topics in transport economics that are relevant for sustainable transport policymaking. Meta-analysis is a research methodology that is based on the quantitative summarisation of a body of previously documented empirical evidence. In several fields of economic, meta-analysis has become a well-accepted research tool. Despite the appeal of the meta-analytical approach, there are methodological difficulties that need to be acknowledged. We study a specific methodological problem which is common in meta-analysis in economics, viz., within-study dependence caused by multiple sampling techniques. By means of Monte Carlo analysis we investigate the effect of such dependence on the performance of various multivariate estimators. In the applied part of the thesis we use and develop meta-analytical techniques to study the empirical variation in indicators of the price sensitivity of demand for aviation transport, the price sensitivity of demand for gasoline, the efficiency of urban public transport and the valuation of the external costs of noise from rail transport. We focus on the estimation of mean values for these indicators and on the identification of the impact of conditioning factors.

Methodology Series Module 6: Systematic Reviews and Meta-analysis.

Science.gov (United States)

Setia, Maninder Singh

2016-01-01

Systematic reviews and meta-analysis have become an important of biomedical literature, and they provide the "highest level of evidence" for various clinical questions. There are a lot of studies - sometimes with contradictory conclusions - on a particular topic in literature. Hence, as a clinician, which results will you believe? What will you tell your patient? Which drug is better? A systematic review or a meta-analysis may help us answer these questions. In addition, it may also help us understand the quality of the articles in literature or the type of studies that have been conducted and published (example, randomized trials or observational studies). The first step it to identify a research question for systematic review or meta-analysis. The next step is to identify the articles that will be included in the study. This will be done by searching various databases; it is important that the researcher should search for articles in more than one database. It will also be useful to form a group of researchers and statisticians that have expertise in conducting systematic reviews and meta-analysis before initiating them. We strongly encourage the readers to register their proposed review/meta-analysis with PROSPERO. Finally, these studies should be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis checklist.

DEVSML 2.0: The Language and the Stack

Science.gov (United States)

2012-03-01

problems outside it. For example, HTML for web pages, Verilog and VHDL for hardware description, etc. are DSLs for very specific domains. A DSL can be...Engineering ( MDE ) paradigm where meta-modeling allows such transformations. The metamodeling approach to Model Integrated Computing (MIC) brings...University of Arizona, 2007 [5] Mittal, S, Martin, JLR, Zeigler, BP, "DEVS-Based Web Services for Net-centric T&E", Summer Computer Simulation

Providing the meta-model of development of competency using the meta-ethnography approach: Part 2. Synthesis of the available competency development models

Directory of Open Access Journals (Sweden)

Shahram Yazdani

2016-12-01

Full Text Available Background and Purpose: ConsideringBackground and Purpose: Considering the importance and necessity of competency-based education at a global level and with respect to globalization and the requirement of minimum competencies in medical fields, medical education communities and organizations worldwide have tried to determine the competencies, present frameworks and education models to respond to be sure of the ability of all graduates. In the literature, we observed numerous competency development models that refer to the same issues with different terminologies. It seems that evaluation and synthesis of all these models can finally result in designing a comprehensive meta-model for competency development.Methods: Meta-ethnography is a useful method for synthesis of qualitative research that is used to develop models that interpret the results in several studies. Considering that the aim of this study is to ultimately provide a competency development meta-model, in the previous section of the study, the literature review was conducted to achieve competency development models. Models obtained through the search were studied in details, and the key concepts of the models and overarching concepts were extracted in this section, models’ concepts were reciprocally translated and the available competency development models were synthesized.Results: A presentation of the competency development meta-model and providing a redefinition of the Dreyfus brothers model.Conclusions: Given the importance of competency-based education at a global level and the need to review curricula and competency-based curriculum design, it is required to provide competency development as well as meta-model to be the basis for curriculum development. As there are a variety of competency development models available, in this study, it was tried to develop the curriculum using them.Keywords: Meta-ethnography, Competency development, Meta-model, Qualitative synthesis

A case study of discordant overlapping meta-analyses: vitamin d supplements and fracture.

Directory of Open Access Journals (Sweden)

Mark J Bolland

Full Text Available BACKGROUND: Overlapping meta-analyses on the same topic are now very common, and discordant results often occur. To explore why discordant results arise, we examined a common topic for overlapping meta-analyses- vitamin D supplements and fracture. METHODS AND FINDINGS: We identified 24 meta-analyses of vitamin D (with or without calcium and fracture in a PubMed search in October 2013, and analysed a sample of 7 meta-analyses in the highest ranking general medicine journals. We used the AMSTAR tool to assess the quality of the meta-analyses, and compared their methodologies, analytic techniques and results. Applying the AMSTAR tool suggested the meta-analyses were generally of high quality. Despite this, there were important differences in trial selection, data extraction, and analytical methods that were only apparent after detailed assessment. 25 trials were included in at least one meta-analysis. Four meta-analyses included all eligible trials according to the stated inclusion and exclusion criteria, but the other 3 meta-analyses "missed" between 3 and 8 trials, and 2 meta-analyses included apparently ineligible trials. The relative risks used for individual trials differed between meta-analyses for total fracture in 10 of 15 trials, and for hip fracture in 6 of 12 trials, because of different outcome definitions and analytic approaches. The majority of differences (11/16 led to more favourable estimates of vitamin D efficacy compared to estimates derived from unadjusted intention-to-treat analyses using all randomised participants. The conclusions of the meta-analyses were discordant, ranging from strong statements that vitamin D prevents fractures to equally strong statements that vitamin D without calcium does not prevent fractures. CONCLUSIONS: Substantial differences in trial selection, outcome definition and analytic methods between overlapping meta-analyses led to discordant estimates of the efficacy of vitamin D for fracture prevention

Occupational and environmental scleroderma. Systematic review and meta-analysis.

Science.gov (United States)

Rubio-Rivas, Manuel; Moreno, Rafael; Corbella, Xavier

2017-03-01

The etiology of systemic sclerosis (SSc) remains unknown; however, several occupational and environmental factors have been implicated. Our objective was to perform a meta-analysis of all studies published on SSc associated with occupational and environmental exposure. The review was undertaken by means of MEDLINE and SCOPUS from 1960 to 2014 and using the terms: "systemic," "scleroderma," or "systemic sclerosis/chemically induced" [MesH]. The Newcastle-Ottawa Scale was used for the qualifying assessment. The inverse variance-weighted method was performed. The meta-analysis of silica exposure included 15 case-control studies [overall OR 2.81 (95%CI 1.86-4.23; p < 0.001)] and 4 cohort studies [overall RR 17.52 (95%CI 5.98-51.37; p < 0.001)]; the meta-analysis of solvents exposure included 13 case-control studies (overall OR 2.00 [95%CI 1.32-3.02; p = 0.001); the meta-analysis of breast implants exposure included 4 case-control studies (overall OR 1.68 (95%CI 1.65-1.71; p < 0.001)) and 6 cohort studies (overall RR 2.13 (95%CI 0.86-5.27; p = 0.10)); the meta-analysis of epoxy resins exposure included 4 case-control studies (overall OR 2.97 (95%CI 2.31-3.83; p < 0.001)), the meta-analysis of pesticides exposure included 3 case-control studies (overall OR 1.02 (95%CI 0.78-1.32; p = 0.90)) and, finally, the meta-analysis of welding fumes exposure included 4 studies (overall OR 1.29 (95%CI 0.44-3.74; p = 0.64)). Not enough studies citing risks related to hair dyes have been published to perform an accurate meta-analysis. Silica and solvents were the two most likely substances related to the pathogenesis of SSc. While silica is involved in particular jobs, solvents are widespread and more people are at risk of having incidental contact with them.

Semantic Web Without SPARQL.pdf

OpenAIRE

Szekely, Pedro

2016-01-01

Discuss the creation of large Semantic Web applications with billions of triples. Instead of using a traditional SPARQL endpoint, our toolchain is a pure JSON toolchain using JSON-LD and ElasticSearch to support queries. The toolchain is familiar to all developers, does not require knowledge of Semantic Web technologies, and performance is 10X better than using SPARQL endpoints. The presentation illustrates the approach in the context of an application to fight human trafficking, using data f...

Meta-Analysis for Sociology – A Measure-Driven Approach

Science.gov (United States)

Roelfs, David J.; Shor, Eran; Falzon, Louise; Davidson, Karina W.; Schwartz, Joseph E.

2013-01-01

Meta-analytic methods are becoming increasingly important in sociological research. In this article we present an approach for meta-analysis which is especially helpful for sociologists. Conventional approaches to meta-analysis often prioritize “concept-driven” literature searches. However, in disciplines with high theoretical diversity, such as sociology, this search approach might constrain the researcher’s ability to fully exploit the entire body of relevant work. We explicate a “measure-driven” approach, in which iterative searches and new computerized search techniques are used to increase the range of publications found (and thus the range of possible analyses) and to traverse time and disciplinary boundaries. We demonstrate this measure-driven search approach with two meta-analytic projects, examining the effects of various social variables on all-cause mortality. PMID:24163498

Meta-analyzing dependent correlations: an SPSS macro and an R script.

Science.gov (United States)

Cheung, Shu Fai; Chan, Darius K-S

2014-06-01

The presence of dependent correlation is a common problem in meta-analysis. Cheung and Chan (2004, 2008) have shown that samplewise-adjusted procedures perform better than the more commonly adopted simple within-sample mean procedures. However, samplewise-adjusted procedures have rarely been applied in meta-analytic reviews, probably due to the lack of suitable ready-to-use programs. In this article, we compare the samplewise-adjusted procedures with existing procedures to handle dependent effect sizes, and present the samplewise-adjusted procedures in a way that will make them more accessible to researchers conducting meta-analysis. We also introduce two tools, an SPSS macro and an R script, that researchers can apply to their meta-analyses; these tools are compatible with existing meta-analysis software packages.

A meta-frontier approach for causal inference in productivity analysis

DEFF Research Database (Denmark)

Henningsen, Arne; Mpeta, Daniel F.; Adem, Anwar S.

(2012) and create a meta-frontier in order to estimate the effects of participation on the farms’ meta-technology ratio, their group technical efficiency, and their meta-technology technical efficiency. The empirical analysis uses a cross-sectional data set from sunflower farmers in Tanzania, where some...... by the contractor’s provision of (additional) extension service and seeds of high-yielding varieties to the contract farmers....

Perceived Discrimination and Health: A Meta-Analytic Review

Science.gov (United States)

Pascoe, Elizabeth A.; Richman, Laura Smart

2009-01-01

Perceived discrimination has been studied with regard to its impact on several types of health effects. This meta-analysis provides a comprehensive account of the relationships between multiple forms of perceived discrimination and both mental and physical health outcomes. In addition, this meta-analysis examines potential mechanisms by which…

Scribl: an HTML5 Canvas-based graphics library for visualizing genomic data over the web.

Science.gov (United States)

Miller, Chase A; Anthony, Jon; Meyer, Michelle M; Marth, Gabor

2013-02-01

High-throughput biological research requires simultaneous visualization as well as analysis of genomic data, e.g. read alignments, variant calls and genomic annotations. Traditionally, such integrative analysis required desktop applications operating on locally stored data. Many current terabyte-size datasets generated by large public consortia projects, however, are already only feasibly stored at specialist genome analysis centers. As even small laboratories can afford very large datasets, local storage and analysis are becoming increasingly limiting, and it is likely that most such datasets will soon be stored remotely, e.g. in the cloud. These developments will require web-based tools that enable users to access, analyze and view vast remotely stored data with a level of sophistication and interactivity that approximates desktop applications. As rapidly dropping cost enables researchers to collect data intended to answer questions in very specialized contexts, developers must also provide software libraries that empower users to implement customized data analyses and data views for their particular application. Such specialized, yet lightweight, applications would empower scientists to better answer specific biological questions than possible with general-purpose genome browsers currently available. Using recent advances in core web technologies (HTML5), we developed Scribl, a flexible genomic visualization library specifically targeting coordinate-based data such as genomic features, DNA sequence and genetic variants. Scribl simplifies the development of sophisticated web-based graphical tools that approach the dynamism and interactivity of desktop applications. Software is freely available online at http://chmille4.github.com/Scribl/ and is implemented in JavaScript with all modern browsers supported.

metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis.

Science.gov (United States)

Cichonska, Anna; Rousu, Juho; Marttinen, Pekka; Kangas, Antti J; Soininen, Pasi; Lehtimäki, Terho; Raitakari, Olli T; Järvelin, Marjo-Riitta; Salomaa, Veikko; Ala-Korpela, Mika; Ripatti, Samuli; Pirinen, Matti

2016-07-01

A dominant approach to genetic association studies is to perform univariate tests between genotype-phenotype pairs. However, analyzing related traits together increases statistical power, and certain complex associations become detectable only when several variants are tested jointly. Currently, modest sample sizes of individual cohorts, and restricted availability of individual-level genotype-phenotype data across the cohorts limit conducting multivariate tests. We introduce metaCCA, a computational framework for summary statistics-based analysis of a single or multiple studies that allows multivariate representation of both genotype and phenotype. It extends the statistical technique of canonical correlation analysis to the setting where original individual-level records are not available, and employs a covariance shrinkage algorithm to achieve robustness.Multivariate meta-analysis of two Finnish studies of nuclear magnetic resonance metabolomics by metaCCA, using standard univariate output from the program SNPTEST, shows an excellent agreement with the pooled individual-level analysis of original data. Motivated by strong multivariate signals in the lipid genes tested, we envision that multivariate association testing using metaCCA has a great potential to provide novel insights from already published summary statistics from high-throughput phenotyping technologies. Code is available at https://github.com/aalto-ics-kepaco anna.cichonska@helsinki.fi or matti.pirinen@helsinki.fi Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press.

EXPLORING IMPLICIT META-DISCOURSE IN LEGAL DISCOURSE: AN ANALYSIS OF THE CHINESE AND AMERICAN CONSTITUTIONS

Directory of Open Access Journals (Sweden)

Mengyu He

2017-09-01

Full Text Available Research in meta-discourse, particularly explicit meta-discourse or meta-discourse markers has contributed much knowledge on the discourse features of specialised genres. However, there are very few studies on implicit meta-discourse. The current study explores implicit meta-discourse in legal discourse by comparing the implicit interpersonal meta-discourse in the Constitution of the People’s Republic of China with the Constitution of the United States. The focus of the study is the use of implicit meta-discourse, particularly the grammatical meta-discourse in the legal discourse of two different languages and cultural groups. The findings demonstrate that there are similarities and differences in the use of implicit meta-discourse in the two constitutions. Within the context of language discourse, the findings of the current study suggest that legal discourse is distinctive in the use of implicit interpersonal meta-discourse, particularly in the way writers intrude into the discourse implicitly by certain key grammatical forms of meta-discourse. Despite the objectivity and rigour of legal discourse, the current study found that there is some level of subjectivity in such discourse, evident from the use of implicit meta-discourse.

MetaQUAST: evaluation of metagenome assemblies.

Science.gov (United States)

Mikheenko, Alla; Saveliev, Vladislav; Gurevich, Alexey

2016-04-01

During the past years we have witnessed the rapid development of new metagenome assembly methods. Although there are many benchmark utilities designed for single-genome assemblies, there is no well-recognized evaluation and comparison tool for metagenomic-specific analogues. In this article, we present MetaQUAST, a modification of QUAST, the state-of-the-art tool for genome assembly evaluation based on alignment of contigs to a reference. MetaQUAST addresses such metagenome datasets features as (i) unknown species content by detecting and downloading reference sequences, (ii) huge diversity by giving comprehensive reports for multiple genomes and (iii) presence of highly relative species by detecting chimeric contigs. We demonstrate MetaQUAST performance by comparing several leading assemblers on one simulated and two real datasets. http://bioinf.spbau.ru/metaquast aleksey.gurevich@spbu.ru Supplementary data are available at Bioinformatics online. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Meta fluid dynamic as a gauge field theory

International Nuclear Information System (INIS)

Mendes, A.C.R.; Neves, C.; Oliveira, W.; Takakura, F.I.

2003-01-01

In this paper, the analog of Maxwell electromagnetism for hydrodynamic turbulence, the meta fluid dynamics, is extended in order to reformulate the meta fluid dynamics as a gauge field theory. That analogy opens up the possibility to investigate this theory as a constrained system. Having this possibility in mind, we propose a Lagrangian to describe this new theory of turbulence and, subsequently, analyze it from the symplectic point of view. From this analysis, a hidden gauge symmetry is revealed, providing a clear interpretation and meaning of the physics behind the meta fluid theory. Also, the geometrical interpretation to the gauge symmetries is discussed. (author)

Meta-Synthesis of Research on Information Seeking Behaviour

Science.gov (United States)

Urquhart, Christine

2011-01-01

Introduction: Meta-synthesis methods may help to make more sense of information behaviour research evidence. Aims and objectives: The objectives are to: 1) identify and examine the theoretical research strategies commonly used in information behaviour research; 2) discuss meta-synthesis methods that might be appropriate to the type of research…

Leisure in transformation: Meta-trends changing the world | Edginton ...

African Journals Online (AJOL)

Meta-trends often arise from underlying shifts in social, cultural, political, ... discussed the impact of several key meta-trends on leisure, quality of life and community ... changes and shifts; 2) social media, technology and universal connectivity; ...

Examining the Inclusion of Quantitative Research in a Meta-Ethnographic Review

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Booker, Rhae-Ann Richardson

2010-01-01

This study explored how one might extend meta-ethnography to quantitative research for the advancement of interpretive review methods. Using the same population of 139 studies on racial-ethnic matching as data, my investigation entailed an extended meta-ethnography (EME) and comparison of its results to a published meta-analysis (PMA). Adhering to…

Conducting meta-analyses of HIV prevention literatures from a theory-testing perspective.

Science.gov (United States)

Marsh, K L; Johnson, B T; Carey, M P

2001-09-01

Using illustrations from HIV prevention research, the current article advocates approaching meta-analysis as a theory-testing scientific method rather than as merely a set of rules for quantitative analysis. Like other scientific methods, meta-analysis has central concerns with internal, external, and construct validity. The focus of a meta-analysis should only rarely be merely describing the effects of health promotion, but rather should be on understanding and explaining phenomena and the processes underlying them. The methodological decisions meta-analysts make in conducting reviews should be guided by a consideration of the underlying goals of the review (e.g., simply effect size estimation or, preferably theory testing). From the advocated perspective that a health behavior meta-analyst should test theory, the authors present a number of issues to be considered during the conduct of meta-analyses.

Curcuminoids Lower Plasma Leptin Concentrations: A Meta-analysis.

Science.gov (United States)

Atkin, Stephen L; Katsiki, Niki; Derosa, Giuseppe; Maffioli, Pamela; Sahebkar, Amirhossein

2017-12-01

Curcumin is a naturally occurring polyphenol that has been suggested to improve several metabolic diseases. Leptin is an adipokine involved in metabolic status and appetite, with marked crosstalk with other systems. Available data suggest that curcumin may affect leptin levels; therefore, this meta-analysis was performed to evaluate this. A systematic review and meta-analysis were undertaken on all randomized controlled trials of curcumin studies that included the measurement of leptin. The search included PubMed-Medline, Scopus, ISI Web of Knowledge, and Google Scholar databases. Quantitative data synthesis was performed by using a random-effects model, with standardized mean difference and 95% confidence interval as summary statistics. A funnel plot, Begg's rank correlation, and Egger's weighted regression tests assessed the presence of publication bias. Four eligible articles comprising five treatment arms were selected for the meta-analysis. Meta-analysis showed a significant decrease in plasma leptin concentrations following curcumin treatment (standardized mean difference: -0.69, 95% confidence interval: -1.16, -0.23, p = 0.003; I 2  = 76.53%). There was no evidence of publication bias. This meta-analysis showed that curcumin supplementation is associated with a decrease in leptin levels that may be regarded as a potential mechanism for the metabolic effects of curcumin. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression

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Cai, Xianlei; Wang, Chen; Yu, Wanqi; Fan, Wenjie; Wang, Shan; Shen, Ning; Wu, Pengcheng; Li, Xiuyang; Wang, Fudi

2016-01-01

The objective of this study was to investigate the associations between selenium exposure and cancer risk. We identified 69 studies and applied meta-analysis, meta-regression and dose-response analysis to obtain available evidence. The results indicated that high selenium exposure had a protective effect on cancer risk (pooled OR = 0.78; 95%CI: 0.73–0.83). The results of linear and nonlinear dose-response analysis indicated that high serum/plasma selenium and toenail selenium had the efficacy on cancer prevention. However, we did not find a protective efficacy of selenium supplement. High selenium exposure may have different effects on specific types of cancer. It decreased the risk of breast cancer, lung cancer, esophageal cancer, gastric cancer, and prostate cancer, but it was not associated with colorectal cancer, bladder cancer, and skin cancer. PMID:26786590

Empirical Comparison of Publication Bias Tests in Meta-Analysis.

Science.gov (United States)

Lin, Lifeng; Chu, Haitao; Murad, Mohammad Hassan; Hong, Chuan; Qu, Zhiyong; Cole, Stephen R; Chen, Yong

2018-04-16

Decision makers rely on meta-analytic estimates to trade off benefits and harms. Publication bias impairs the validity and generalizability of such estimates. The performance of various statistical tests for publication bias has been largely compared using simulation studies and has not been systematically evaluated in empirical data. This study compares seven commonly used publication bias tests (i.e., Begg's rank test, trim-and-fill, Egger's, Tang's, Macaskill's, Deeks', and Peters' regression tests) based on 28,655 meta-analyses available in the Cochrane Library. Egger's regression test detected publication bias more frequently than other tests (15.7% in meta-analyses of binary outcomes and 13.5% in meta-analyses of non-binary outcomes). The proportion of statistically significant publication bias tests was greater for larger meta-analyses, especially for Begg's rank test and the trim-and-fill method. The agreement among Tang's, Macaskill's, Deeks', and Peters' regression tests for binary outcomes was moderately strong (most κ's were around 0.6). Tang's and Deeks' tests had fairly similar performance (κ > 0.9). The agreement among Begg's rank test, the trim-and-fill method, and Egger's regression test was weak or moderate (κ < 0.5). Given the relatively low agreement between many publication bias tests, meta-analysts should not rely on a single test and may apply multiple tests with various assumptions. Non-statistical approaches to evaluating publication bias (e.g., searching clinical trials registries, records of drug approving agencies, and scientific conference proceedings) remain essential.

Systematic review and meta-analysis of glyphosate exposure and risk of lymphohematopoietic cancers.

Science.gov (United States)

Chang, Ellen T; Delzell, Elizabeth

2016-01-01

This systematic review and meta-analysis rigorously examines the relationship between glyphosate exposure and risk of lymphohematopoietic cancer (LHC) including NHL, Hodgkin lymphoma (HL), multiple myeloma (MM), and leukemia. Meta-relative risks (meta-RRs) were positive and marginally statistically significant for the association between any versus no use of glyphosate and risk of NHL (meta-RR = 1.3, 95% confidence interval (CI) = 1.0-1.6, based on six studies) and MM (meta-RR = 1.4, 95% CI = 1.0-1.9; four studies). Associations were statistically null for HL (meta-RR = 1.1, 95% CI = 0.7-1.6; two studies), leukemia (meta-RR = 1.0, 95% CI = 0.6-1.5; three studies), and NHL subtypes except B-cell lymphoma (two studies each). Bias and confounding may account for observed associations. Meta-analysis is constrained by few studies and a crude exposure metric, while the overall body of literature is methodologically limited and findings are not strong or consistent. Thus, a causal relationship has not been established between glyphosate exposure and risk of any type of LHC.

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Comparing Active Pediatric Obesity Treatments Using Meta-Analysis

Science.gov (United States)

Gilles, Allyson; Cassano, Michael; Shepherd, Elizabeth J.; Higgins, Diana; Hecker, Jeffrey E.; Nangle, Douglas W.

2008-01-01

The current meta-analysis reviews research on the treatment of pediatric obesity focusing on studies that have been published since 1994. Eleven studies (22 comparisons, 115 effect sizes, N = 447) were included in the present meta-analysis. Results indicated that comprehensive behavioral interventions may be improved in at least two ways:…

How to conduct a qualitative meta-analysis: Tailoring methods to enhance methodological integrity.

Science.gov (United States)

Levitt, Heidi M

2018-05-01

Although qualitative research has long been of interest in the field of psychology, meta-analyses of qualitative literatures (sometimes called meta-syntheses) are still quite rare. Like quantitative meta-analyses, these methods function to aggregate findings and identify patterns across primary studies, but their aims, procedures, and methodological considerations may vary. This paper explains the function of qualitative meta-analyses and their methodological development. Recommendations have broad relevance but are framed with an eye toward their use in psychotherapy research. Rather than arguing for the adoption of any single meta-method, this paper advocates for considering how procedures can best be selected and adapted to enhance a meta-study's methodological integrity. Through the paper, recommendations are provided to help researchers identify procedures that can best serve their studies' specific goals. Meta-analysts are encouraged to consider the methodological integrity of their studies in relation to central research processes, including identifying a set of primary research studies, transforming primary findings into initial units of data for a meta-analysis, developing categories or themes, and communicating findings. The paper provides guidance for researchers who desire to tailor meta-analytic methods to meet their particular goals while enhancing the rigor of their research.

Graphics and Statistics for Cardiology: Data visualisation for meta-analysis.

Science.gov (United States)

Kiran, Amit; Crespillo, Abel Pérez; Rahimi, Kazem

2017-01-01

Graphical displays play a pivotal role in understanding data sets and disseminating results. For meta-analysis, they are instrumental in presenting findings from multiple studies. This report presents guidance to authors wishing to submit graphical displays as part of their meta-analysis to a clinical cardiology journal, such as HeartWhen using graphical displays for meta-analysis, we recommend the following: Use a flow diagram to describe the number of studies returned from the initial search, the inclusion/exclusion criteria applied and the final number of studies used in the meta-analysis.Present results from the meta-analysis using a figure that incorporates a forest plot and underlying (tabulated) statistics, including test for heterogeneity.Use displays such as funnel plot (minimum 10 studies) and Galbraith plot to visually present distribution of effect sizes or associations in order to evaluate small-study effects and publication bias).For meta-regression, the bubble plot is a useful display for assessing associations by study-level factors.Final checks on graphs, such as appropriate use of axis scale, line pattern, text size and graph resolution, should always be performed. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies

DEFF Research Database (Denmark)

Gyöngyösi, Mariann; Wojakowski, Wojciech; Navarese, Eliano P

2016-01-01

In contrast to multiple publication-based meta-analyses involving clinical cardiac regeneration therapy in patients with recent myocardial infarction, a recently published meta-analysis based on individual patient data reported no effect of cell therapy on left ventricular function or clinical...

Inflammatory bowel disease meta-evidence and its challenges

DEFF Research Database (Denmark)

Delaney, J; Laws, P; Wille-Jørgensen, P

2015-01-01

AIM: The aim of this study was to compare the methodological quality and input paper characteristics of systematic reviews and meta-analyses reported in the medical and surgical literature by performing a systematic 'overview of reviews'. Ulcerative colitis (UC) and Crohn's disease (CD) were used...... offer a positive conclusion. The papers used to generate meta-evidence in M papers have a greater degree of corporate and government sponsorship, and are more likely to come from journals with higher impact factors.......AIM: The aim of this study was to compare the methodological quality and input paper characteristics of systematic reviews and meta-analyses reported in the medical and surgical literature by performing a systematic 'overview of reviews'. Ulcerative colitis (UC) and Crohn's disease (CD) were used...... as the framework for this comparison as they are relatively common serious conditions, with both medical and surgical options for therapy. METHOD: Medline, Embase, CINHAL and the Cochrane Database were searched to November 2013. Eligible papers were systematic reviews or meta-analyses that considered a question...

Asymmetric and symmetric meta-correlations in financial markets

International Nuclear Information System (INIS)

Li Xiaohui; Shen Xiangying; Huang Jiping

2016-01-01

In financial markets, the relation between fluctuations of stock prices and trading behaviors is complex. It is intriguing to quantify this kind of meta-correlation between market fluctuations and the synchronous behaviors. We refine the theoretical index leverage model proposed by Reigneron et al. , to exactly quantify the meta-correlation under various levels of price fluctuations [Reigneron P A, Allez R and Bouchaud J P 2011 Physica A 390 3026]. The characteristics of meta-correlations in times of market losses, are found to be significantly different in Chinese and American financial markets. In addition, unlike the asymmetric results at the daily scale, the correlation behaviors are found to be symmetric at the high-frequency scale. (paper)

Mass meta-analysis in Talairach space

DEFF Research Database (Denmark)

Nielsen, Finn Årup

2004-01-01

We provide a method for mass meta-analysis in a neuroinformatics database containing stereotaxic Talairach coordinates from neuroimaging experiments. Database labels are used to group the individual experiments, e.g., according to cognitive function, and the consistent pattern of the experiments...... of experiments, and the distances to the null hypotheses are used to sort the voxels across groups of experiments. This allows for mass meta-analysis, with the construction of a list with the most prominent associations between brain areas and group labels. Furthermore, the method can be used for functional...

Introducing Meta-Partition, a Useful Methodology to Explore Factors That Influence Ecological Effect Sizes.

Directory of Open Access Journals (Sweden)

Zaida Ortega

Full Text Available The study of the heterogeneity of effect sizes is a key aspect of ecological meta-analyses. Here we propose a meta-analytic methodology to study the influence of moderators in effect sizes by splitting heterogeneity: meta-partition. To introduce this methodology, we performed a meta-partition of published data about the traits that influence species sensitivity to habitat loss, that have been previously analyzed through meta-regression. Thus, here we aim to introduce meta-partition and to make an initial comparison with meta-regression. Meta-partition algorithm consists of three steps. Step 1 is to study the heterogeneity of effect sizes under the assumption of fixed effect model. If heterogeneity is found, we perform step 2, that is, to partition the heterogeneity by the moderator that minimizes heterogeneity within a subset while maximizing heterogeneity between subsets. Then, if effect sizes of the subset are still heterogeneous, we repeat step 1 and 2 until we reach final subsets. Finally, step 3 is to integrate effect sizes of final subsets, with fixed effect model if there is homogeneity, and with random effects model if there is heterogeneity. Results show that meta-partition is valuable to assess the importance of moderators in explaining heterogeneity of effect sizes, as well as to assess the directions of these relations and to detect possible interactions between moderators. With meta-partition we have been able to evaluate the importance of moderators in a more objective way than with meta-regression, and to visualize the complex relations that may exist between them. As ecological issues are often influenced by several factors interacting in complex ways, ranking the importance of possible moderators and detecting possible interactions would make meta-partition a useful exploration tool for ecological meta-analyses.

MISTRAL : A Language for Model Transformations in the MOF Meta-modeling Architecture

NARCIS (Netherlands)

Kurtev, Ivan; van den Berg, Klaas; Aßmann, Uwe; Aksit, Mehmet; Rensink, Arend

2005-01-01

n the Meta Object Facility (MOF) meta-modeling architecture a number of model transformation scenarios can be identified. It could be expected that a meta-modeling architecture will be accompanied by a transformation technology supporting the model transformation scenarios in a uniform way. Despite

The Economic Value of Mangroves: A Meta-Analysis

Science.gov (United States)

Marwa Salem; D. Evan Mercer

2012-01-01

This paper presents a synthesis of the mangrove ecosystem valuation literature through a meta-regression analysis. The main contribution of this study is that it is the first meta-analysis focusing solely on mangrove forests, whereas previous studies have included different types of wetlands. The number of studies included in the regression analysis is 44 for a total...

Comparison of Maladaptive Meta Cognition Beliefs among Substance Dependents and Non-Dependents

Directory of Open Access Journals (Sweden)

Omid Saed

2011-05-01

Full Text Available Introduction: The aim of present research was the comparison of maladaptive meta cognition beliefs among substance abusers and non abusers. Methods: For this purpose 70 substance abusers and 70 individuals from the general population by purposive sampling participated in this research and responded to meta cognition questionnaire. For analysis data multiple analysis of variance (MANOVA and discriminant analysis were run. Results: MANOVA revealed that there was significant difference in linier combination of dependent variables (meta cognitive beliefs among two groups also, analysis of dependent variables lonely showed that two groups were significantly different in Positive meta cognitive beliefs, "Negative meta cognitive beliefs", "lack of cognitive confidence", "need to control of thoughts", and "cognitive self-consciousness". Also, the discriminant analysis indicated that three meta-cognitive factors included “negative meta cognitive beliefs", "need to control of thoughts" and "cognitive self-consciousness" were significant predictors to discriminate substance abusers. Conclusion: With consideration of the results it can be concluded that substance abusers have more maladaptive beliefs and these maladaptive beliefs can lead to susceptibility toward substance abuse and staying in this disorder. It is hoped that psychotherapists can be more useful in treating and staying in this research.

Small studies are more heterogeneous than large ones: a meta-meta-analysis

NARCIS (Netherlands)

Hout, J. in't; Ioannidis, J.P.; Borm, G.F.; Goeman, J.J.

2015-01-01

OBJECTIVES: Between-study heterogeneity plays an important role in random-effects models for meta-analysis. Most clinical trials are small, and small trials are often associated with larger effect sizes. We empirically evaluated whether there is also a relationship between trial size and

Apparently conclusive meta-analyses may be inconclusive--Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses

DEFF Research Database (Denmark)

Brok, Jesper; Thorlund, Kristian; Wetterslev, Jørn

2008-01-01

BACKGROUND: Random error may cause misleading evidence in meta-analyses. The required number of participants in a meta-analysis (i.e. information size) should be at least as large as an adequately powered single trial. Trial sequential analysis (TSA) may reduce risk of random errors due to repeti......BACKGROUND: Random error may cause misleading evidence in meta-analyses. The required number of participants in a meta-analysis (i.e. information size) should be at least as large as an adequately powered single trial. Trial sequential analysis (TSA) may reduce risk of random errors due...

Methodological Quality Assessment of Meta-analyses in Endodontics.

Science.gov (United States)

Kattan, Sereen; Lee, Su-Min; Kohli, Meetu R; Setzer, Frank C; Karabucak, Bekir

2018-01-01

The objectives of this review were to assess the methodological quality of published meta-analyses related to endodontics using the assessment of multiple systematic reviews (AMSTAR) tool and to provide a follow-up to previously published reviews. Three electronic databases were searched for eligible studies according to the inclusion and exclusion criteria: Embase via Ovid, The Cochrane Library, and Scopus. The electronic search was amended by a hand search of 6 dental journals (International Endodontic Journal; Journal of Endodontics; Australian Endodontic Journal; Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology; Endodontics and Dental Traumatology; and Journal of Dental Research). The searches were conducted to include articles published after July 2009, and the deadline for inclusion of the meta-analyses was November 30, 2016. The AMSTAR assessment tool was used to evaluate the methodological quality of all included studies. A total of 36 reports of meta-analyses were included. The overall quality of the meta-analyses reports was found to be medium, with an estimated mean overall AMSTAR score of 7.25 (95% confidence interval, 6.59-7.90). The most poorly assessed areas were providing an a priori design, the assessment of the status of publication, and publication bias. In recent publications in the field of endodontics, the overall quality of the reported meta-analyses is medium according to AMSTAR. Copyright © 2017 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

As Limitações dos Sistemas de Metas

Directory of Open Access Journals (Sweden)

Mário Teixeira Reis Neto

2011-04-01

Full Text Available Neste ambiente de grandes incertezas em que as organizações estão inseridas, a correta utilização de um sistema de medição pode significar vantagem competitiva e desempenho. Este ensaio procura esclarecer os limites dos sistemas de medição, verificando se a utilização de metas de resultado é suficiente para que uma empresa tenha um desempenho superior. O objetivo é analisar a teoria das metas sob um olhar crítico, observando os limites da utilização de diversos tipos de metas, até mesmo no serviço público. Buscou-se fazer uma análise das pesquisas dos autores que defendem a utilização de metas para se ter desempenho e, a partir das suas premissas, analisar os estudos dos autores que as criticam, mostrando que elas podem causar, dependendo da situação, sérios danos financeiros e à imagem da organização. Após essa análise, verificou-se que as metas possuem um importante papel no aumento do desempenho da organização, todavia, deve-se ter certo cuidado na sua utilização, pois elas podem levar as pessoas a comportamentos não éticos, à inibição da cooperação e do aprendizado organizacional, entre outros.

Meta-analysis of expression and function of neprilysin in Alzheimer's disease.

Science.gov (United States)

Zhang, Huifeng; Liu, Dan; Wang, Yixing; Huang, Huanhuan; Zhao, Yujia; Zhou, Hui

2017-09-14

Neprilysin (NEP) is one of the most important Aβ-degrading enzymes, and its expression and activity in Alzheimer's brain have been widely reported, but the results remain debatable. Thus, the meta-analysis was performed to elucidate the role of NEP in Alzheimer's disease (AD). The relevant case-control or cohort studies were retrieved according to our inclusion/exclusion criteria. Six studies with 123 controls and 141 AD cases, seven studies with 102 controls and 90 AD cases, and four studies with 93 controls and 132 AD cases were included in meta-analysis of NEP's protein, mRNA, and enzyme activity respectively. We conducted Meta regression to detect the sources of heterogeneity and further performed cumulative meta-analysis or subgroup analysis. Our meta-analysis revealed a significantly lower level of NEP mRNA (SMD=-0.44, 95%CI: -0.87, -0.00, p=0.049) in AD cases than in non-AD cases, and such pattern was not altered over time in the cumulative meta-analysis. However, the decrease of NEP protein (SMD=-0.18, 95%CI: -0.62, 0.25) and enzyme activity (SMD=-0.35, 95%CI: -1.03, 0.32) in AD cases did not pass the significance check, while the cumulative meta-analysis by average age showed the pooled effect became insignificant as adding the studies with younger subjects, which indicates that the protein expression and enzyme activity of NEP in the cortex are affected by age. Therefore, the present meta-analysis suggests the need of further investigation of roles of NEP in AD pathogenesis and treatment. Copyright © 2017 Elsevier B.V. All rights reserved.

Meta-analysis for evidence synthesis in plant pathology: an overview.

Science.gov (United States)

Madden, L V; Paul, P A

2011-01-01

Meta-analysis is the analysis of the results of multiple studies, which is typically performed in order to synthesize evidence from many possible sources in a formal probabilistic manner. In a simple sense, the outcome of each study becomes a single observation in the meta-analysis of all available studies. The methodology was developed originally in the social sciences by Smith, Glass, Rosenthal, Hunter, and Schmidt, based on earlier pioneering contributions in statistics by Fisher, Pearson, Yates, and Cochran, but this approach to research synthesis has now been embraced within many scientific disciplines. However, only a handful of articles have been published in plant pathology and related fields utilizing meta-analysis. After reviewing basic concepts and approaches, methods for estimating parameters and interpreting results are shown. The advantages of meta-analysis are presented in terms of prediction and risk analysis, and the high statistical power that can be achieved for detecting significant effects of treatments or significant relationships between variables. Based on power considerations, the fallacy of naïve counting of P values in a narrative review is demonstrated. Although there are many advantages to meta-analysis, results can be biased if the analysis is based on a nonrepresentative sample of study outcomes. Therefore, novel approaches for characterizing the upper bound on the bias are discussed, in order to show the robustness of meta-analysis to possible violation of assumptions.

A new miniaturized negative-index meta-atom for tri-band applications

Directory of Open Access Journals (Sweden)

Hossain Mohammad Jakir

2017-07-01

Full Text Available In this paper, a miniature negative index meta-atom was designed; simulated, fabricated and measured based on parallel incidence of electromagnetic wave that can maintain a tri-band applications in microwave spectra. Compare to the other multi-band conventional metamaterial, the proposed meta-atom structure allows miniaturization factor and follows better effective medium ratio (EMR. Finite-integration technique (FIT based computer simulation technology (CST electromagnetic simulator was adopted to examine the design of the meta-atom. It exhibits tri-band response in conjunction with backward wave property over a certain frequency band in the microwave regime. Furthermore, the effective medium ratio is considerably improved compared to previously reported metamaterial. Moreover, few parametric analyses were done with the meta-atom. The size, scattering parameters and effective medium parameters of the proposed negative index miniaturized meta-atom is appropriate for tri-band applications.

ESTABLECIMIENTO DE METAS, COMPORTAMIENTO Y DESEMPEÑO

Directory of Open Access Journals (Sweden)

2000-01-01

Full Text Available Existen varios enfoques motivacionales que se inclinan más hacia las causas próximas del comportamiento que hacia las necesidades y características (la suposición básica es que las personas se sienten más motivadas cuando sus valores, sus necesidades y su carácter se ajustan al contexto laboral y organizacional que cuando no lo están. Los enfoques de causas próximas al comportamiento se centran principalmente en las creencias que la gente tiene acerca de su propio desempeño, como por ejemplo lo que están tratando de hacer, desean hacer, piensan que pueden hacer, o realmente esperan hacer. Estos enfoques específicos se basan en el supuesto de que las creencias propias acerca de las actividades futuras de una persona (y las propias interpretaciones de actividades pasadas influyen en sus acciones en el presente. En esta última categoría se incluyen las teorías del establecimiento de metas, la auto-eficacia y las expectativas. Estas teorías se asemejan en cuanto a que cada concepto requiere que la gente piense y juzgue su desempeño futuro con base en las experiencias pasadas y su valoración del momento. Las metas tienden a reflejar lo que la gente desea hacer, la auto-eficacia refleja lo que la gente piensa que puede hacer y las expectativas reflejan el “mejor estimativo” que tiene la gente sobre las consecuencias de sus acciones.En este documento se revisan criterios para comprender la relación entre el establecimiento de metas y el desempeño, incluyendo definiciones, diferentes medidas, perspectivas, enfoques, mediadores y moderadores, sobre diferentes investigaciones prácticas acerca del establecimiento de metas. Finalmente, este escrito proporciona la base para propuestas de investigación específicas concernientes a la confiabilidad y validez de la medida y la posibilidad de generalizar esta teoría para distintas tareas (por ejemplo, labores complejas, dificultad de las metas, trabajos novedosos, para diversas

Systematic reviews with meta-analysis: Why, when, and how?

NARCIS (Netherlands)

Crocetti, E.

2016-01-01

Systematic reviews with meta-analysis represent the gold standard for conducting reliable and transparent reviews of the literature. The purpose of this article is threefold: (a) to address why and when it is worthwhile to conduct a systematic review with meta-analysis, covering advantages of this

The ATLAS PanDA Monitoring System and its Evolution

Science.gov (United States)

Klimentov, A.; Nevski, P.; Potekhin, M.; Wenaus, T.

2011-12-01

The PanDA (Production and Distributed Analysis) Workload Management System is used for ATLAS distributed production and analysis worldwide. The needs of ATLAS global computing imposed challenging requirements on the design of PanDA in areas such as scalability, robustness, automation, diagnostics, and usability for both production shifters and analysis users. Through a system-wide job database, the PanDA monitor provides a comprehensive and coherent view of the system and job execution, from high level summaries to detailed drill-down job diagnostics. It is (like the rest of PanDA) an Apache-based Python application backed by Oracle. The presentation layer is HTML code generated on the fly in the Python application which is also responsible for managing database queries. However, this approach is lacking in user interface flexibility, simplicity of communication with external systems, and ease of maintenance. A decision was therefore made to migrate the PanDA monitor server to Django Web Application Framework and apply JSON/AJAX technology in the browser front end. This allows us to greatly reduce the amount of application code, separate data preparation from presentation, leverage open source for tools such as authentication and authorization mechanisms, and provide a richer and more dynamic user experience. We describe our approach, design and initial experience with the migration process.

The ATLAS PanDA Monitoring System and its Evolution

International Nuclear Information System (INIS)

Klimentov, A; Nevski, P; Wenaus, T; Potekhin, M

2011-01-01

The PanDA (Production and Distributed Analysis) Workload Management System is used for ATLAS distributed production and analysis worldwide. The needs of ATLAS global computing imposed challenging requirements on the design of PanDA in areas such as scalability, robustness, automation, diagnostics, and usability for both production shifters and analysis users. Through a system-wide job database, the PanDA monitor provides a comprehensive and coherent view of the system and job execution, from high level summaries to detailed drill-down job diagnostics. It is (like the rest of PanDA) an Apache-based Python application backed by Oracle. The presentation layer is HTML code generated on the fly in the Python application which is also responsible for managing database queries. However, this approach is lacking in user interface flexibility, simplicity of communication with external systems, and ease of maintenance. A decision was therefore made to migrate the PanDA monitor server to Django Web Application Framework and apply JSON/AJAX technology in the browser front end. This allows us to greatly reduce the amount of application code, separate data preparation from presentation, leverage open source for tools such as authentication and authorization mechanisms, and provide a richer and more dynamic user experience. We describe our approach, design and initial experience with the migration process.

Parents' experiences of neonatal transfer. A meta-study of qualitative research 2000-2017.

Science.gov (United States)

Aagaard, Hanne; Hall, Elisabeth O C; Ludvigsen, Mette S; Uhrenfeldt, Lisbeth; Fegran, Liv

2018-02-15

Transfers of critically ill neonates are frequent phenomena. Even though parents' participation is regarded as crucial in neonatal care, a transfer often means that parents and neonates are separated. A systematic review of the parents' experiences of neonatal transfer is lacking. This paper describes a meta-study addressing qualitative research about parents' experiences of neonatal transfer. Through deconstruction and reflections of theories, methods, and empirical data, the aim was to achieve a deeper understanding of theoretical, empirical, contextual, historical, and methodological issues of qualitative studies concerning parents' experiences of neonatal transfer over the course of this meta-study (2000-2017). Meta-theory and meta-method analyses showed that caring, transition, and family-centered care were main theoretical frames applied and that interviewing with a small number of participants was the preferred data collection method. The meta-data-analysis showed that transfer was a scary, unfamiliar, and threatening experience for the parents; they were losing familiar context, were separated from their neonate, and could feel their parenthood disrupted. We identified 'wavering and wandering' as a metaphoric representation of the parents' experiences. The findings add knowledge about meta-study as an approach for comprehensive qualitative research and point at the value of meta-theory and meta-method analyses. © 2018 John Wiley & Sons Ltd.

A systematic review of the quality and impact of anxiety disorder meta-analyses.

Science.gov (United States)

Ipser, Jonathan C; Stein, Dan J

2009-08-01

Meta-analyses are seen as representing the pinnacle of a hierarchy of evidence used to inform clinical practice. Therefore, the potential importance of differences in the rigor with which they are conducted and reported warrants consideration. In this review, we use standardized instruments to describe the scientific and reporting quality of meta-analyses of randomized controlled trials of the treatment of anxiety disorders. We also use traditional and novel metrics of article impact to assess the influence of meta-analyses across a range of research fields in the anxiety disorders. Overall, although the meta-analyses that we examined had some flaws, their quality of reporting was generally acceptable. Neither the scientific nor reporting quality of the meta-analyses was predicted by any of the impact metrics. The finding that treatment meta-analyses were cited less frequently than quantitative reviews of studies in current "hot spots" of research (ie, genetics, imaging) points to the multifactorial nature of citation patterns. A list of the meta-analyses included in this review is available on an evidence-based website of anxiety and trauma-related disorders.

Parents’ experiences of neonatal transfer. A meta-study of qualitative research 2000-2017

DEFF Research Database (Denmark)

Aagaard, Hanne; Hall, Elisabeth; Ludvigsen, Mette Spliid

2018-01-01

Transfers of critically ill neonates are frequent phenomena. Even though parents’ par- ticipation is regarded as crucial in neonatal care, a transfer often means that parents and neonates are separated. A systematic review of the parents’ experiences of neo- natal transfer is lacking. This paper ...... identified ‘wavering and wandering’ as a metaphoric representation of the parents’ experiences. The findings add knowledge about meta- study as an approach for com- prehensive qualitative research and point at the value of meta- theory and meta- method analyses....... describes a meta- study addressing qualitative re- search about parents’ experiences of neonatal transfer. Through deconstruction and reflections of theories, methods, and empirical data, the aim was to achieve a deeper understanding of theoretical, empirical, contextual, historical, and methodological is......- sues of qualitative studies concerning parents’ experiences of neonatal transfer over the course of this meta- study (2000–2017). Meta- theory and meta- method analyses showed that caring, transition, and family- centered care were main theoretical frames applied and that interviewing with a small...

Less is less: a systematic review of graph use in meta-analyses.

Science.gov (United States)

Schild, Anne H E; Voracek, Martin

2013-09-01

Graphs are an essential part of scientific communication. Complex datasets, of which meta-analyses are textbook examples, benefit the most from visualization. Although a number of graph options for meta-analyses exist, the extent to which these are used was hitherto unclear. A systematic review on graph use in meta-analyses in three disciplines (medicine, psychology, and business) and nine journals was conducted. Interdisciplinary differences, which are mirrored in the respective journals, were revealed, that is, graph use correlates with external factors rather than methodological considerations. There was only limited variation in graph types (with forest plots as the most important representatives), and diagnostic plots were very rare. Although an increase in graph use over time could be observed, it is unlikely that this phenomenon is specific to meta-analyses. There is a gaping discrepancy between available graphic methods and their application in meta-analyses. This may be rooted in a number of factors, namely, (i) insufficient dissemination of new developments, (ii) unsatisfactory implementation in software packages, and (iii) minor attention on graphics in meta-analysis reporting guidelines. Using visualization methods to their full capacity is a further step in using meta-analysis to its full potential. Copyright © 2013 John Wiley & Sons, Ltd.

Meta-analysis in a nutshell: Techniques and general findings

DEFF Research Database (Denmark)

Paldam, Martin

2015-01-01

The purpose of this article is to introduce the technique and main findings of meta-analysis to the reader, who is unfamiliar with the field and has the usual objections. A meta-analysis is a quantitative survey of a literature reporting estimates of the same parameter. The funnel showing...

Updated Meta-Analysis of Learner Control within Educational Technology

Science.gov (United States)

Karich, Abbey C.; Burns, Matthew K.; Maki, Kathrin E.

2014-01-01

Giving a student control over their learning has theoretical and intuitive appeal, but its effects are neither powerful nor consistent in the empirical literature base. This meta-analysis updated previous meta-analytic research by Niemiec, Sikorski, and Walberg by studying the overall effectiveness of providing learner control within educational…

Internet Renewable energy Information System (IRIS)

DEFF Research Database (Denmark)

Bäurle, Britta; Nielsen, Vilhjalmur; Ménard, Lionel

1999-01-01

Even though the Internet is now a widely accessible data source, the unorganised flood of information makes a specific request e.g. for renewable energy products inefficient. In addition, existing databases on renewable energies are often old and incomplete. The objective of IRIS has been...... to organise and retrieve renewable energy product information on the Internet instead of collecting it manually. Updating coincides with the self interestself-interest of manufacturers to present their latest renewable energy products on their own HTML documents. IRIS is based on a set of powerful tools...... and intends to find, extract, collect and index HTML documents with standardised META tags that are widely spread across web servers on the Internet. This paper presents the structure of IRIS, the software tools, and gives one example of how to categorise and prepare web-sites with product information...

Hypothyroidism and carpal tunnel syndrome: a meta-analysis.

Science.gov (United States)

Shiri, Rahman

2014-12-01

This study aimed to assess the magnitude of the association between hypothyroidism and carpal tunnel syndrome (CTS). Eighteen studies were included in a random-effects meta-analysis. A meta-analysis of the studies that did not control their estimates for any confounder showed an association between a thyroid disease (hypo- or hyperthyroidism) and CTS (N = 9,573, effect size [ES] = 1.32 (95% confidence interval [CI], 1.04-1.68) and between hypothyroidism and CTS (N = 64,531, ES = 2.15 [95% CI, 1.64-2.83]). When a meta-analysis limited to the studies that controlled their estimates for some potential confounders, the association between a thyroid disease and CTS disappeared (N = 4,799, ES = 1.17 [95% CI, 0.71-1.92], I(2) = 0%), and the effect size for hypothyroidism largely attenuated (N = 71,133, ES = 1.44 [95% CI, 1.27-1.63], I(2) = 0%). Moreover, there was evidence of publication bias. This meta-analysis found only a modest association between hypothyroidism and CTS. Confounding and publication bias may still account for part of the remaining excess risk. © 2014 Wiley Periodicals, Inc.

Meta-analysis on the efficacy of foot-and-mouth disease emergency vaccination

DEFF Research Database (Denmark)

Hisham Beshara Halasa, Tariq; Boklund, Anette; Cox, S.

2012-01-01

The objectives of this study were to provide a summary quantification of the efficacy of FMD emergency vaccination based on a systematic review and a meta-analysis of available literature, and to further discuss the suitability of this review and meta-analysis to summarize and further interpret...... of clinical signs including FMD lesions and fever, while the virological protection parameter was estimated based on the outcome of laboratory tests that were used to diagnose FMD infection. A meta-analysis relative risk was calculated per protection parameter. Results of the meta-analyses were examined using...... vaccine. Fortunately, no significant bias that would alter the conclusions was encountered in the analysis. Meta-analysis showed to be a useful tool to summarize literature results from a systematic review of the efficacy of foot and mouth disease emergency vaccination....

The politics of meta-governance in transnational private sustainability governance

NARCIS (Netherlands)

Fransen, L.

2015-01-01

In order to address challenges resulting from interactions between transnational private sustainability standard organizations, initiatives emerge that meta-govern these standards. Contrary to prevailing understandings in public policy literature, such meta-governance initiatives are mostly run by

Meta-shell Approach for Constructing Lightweight and High Resolution X-Ray Optics

Science.gov (United States)

McClelland, Ryan S.

2016-01-01

Lightweight and high resolution optics are needed for future space-based x-ray telescopes to achieve advances in high-energy astrophysics. Past missions such as Chandra and XMM-Newton have achieved excellent angular resolution using a full shell mirror approach. Other missions such as Suzaku and NuSTAR have achieved lightweight mirrors using a segmented approach. This paper describes a new approach, called meta-shells, which combines the fabrication advantages of segmented optics with the alignment advantages of full shell optics. Meta-shells are built by layering overlapping mirror segments onto a central structural shell. The resulting optic has the stiffness and rotational symmetry of a full shell, but with an order of magnitude greater collecting area. Several meta-shells so constructed can be integrated into a large x-ray mirror assembly by proven methods used for Chandra and XMM-Newton. The mirror segments are mounted to the meta-shell using a novel four point semi-kinematic mount. The four point mount deterministically locates the segment in its most performance sensitive degrees of freedom. Extensive analysis has been performed to demonstrate the feasibility of the four point mount and meta-shell approach. A mathematical model of a meta-shell constructed with mirror segments bonded at four points and subject to launch loads has been developed to determine the optimal design parameters, namely bond size, mirror segment span, and number of layers per meta-shell. The parameters of an example 1.3 m diameter mirror assembly are given including the predicted effective area. To verify the mathematical model and support opto-mechanical analysis, a detailed finite element model of a meta-shell was created. Finite element analysis predicts low gravity distortion and low thermal distortion. Recent results are discussed including Structural Thermal Optical Performance (STOP) analysis as well as vibration and shock testing of prototype meta-shells.

CrossFit Overview: Systematic Review and Meta-analysis.

Science.gov (United States)

Claudino, João Gustavo; Gabbett, Tim J; Bourgeois, Frank; Souza, Helton de Sá; Miranda, Rafael Chagas; Mezêncio, Bruno; Soncin, Rafael; Cardoso Filho, Carlos Alberto; Bottaro, Martim; Hernandez, Arnaldo Jose; Amadio, Alberto Carlos; Serrão, Julio Cerca

2018-02-26

CrossFit is recognized as one of the fastest growing high-intensity functional training modes in the world. However, scientific data regarding the practice of CrossFit is sparse. Therefore, the objective of this study is to analyze the findings of scientific literature related to CrossFit via systematic review and meta-analysis. Systematic searches of the PubMed, Web of Science, Scopus, Bireme/MedLine, and SciELO online databases were conducted for articles reporting the effects of CrossFit training. The systematic review followed the PRISMA guidelines. The Oxford Levels of Evidence was used for all included articles, and only studies that investigated the effects of CrossFit as a training program were included in the meta-analysis. For the meta-analysis, effect sizes (ESs) with 95% confidence interval (CI) were calculated and heterogeneity was assessed using a random-effects model. Thirty-one articles were included in the systematic review and four were included in the meta-analysis. However, only two studies had a high level of evidence at low risk of bias. Scientific literature related to CrossFit has reported on body composition, psycho-physiological parameters, musculoskeletal injury risk, life and health aspects, and psycho-social behavior. In the meta-analysis, significant results were not found for any variables. The current scientific literature related to CrossFit has few studies with high level of evidence at low risk of bias. However, preliminary data has suggested that CrossFit practice is associated with higher levels of sense of community, satisfaction, and motivation.

Meta-analysis in epidemiology | Yach | South African Medical Journal

African Journals Online (AJOL)

Meta-analysis is the structured and systematic qualitative and quantitative integration of the results of several independent studies (Le. the epidemiology of results). As in any epidemiological study, a meta-analysis needs to start with clearly stated aims and objectives. Attention needs to be paid to selection bias in selecting ...

Incidence and predictors of oral feeding intolerance in acute pancreatitis: A systematic review, meta-analysis, and meta-regression.

Science.gov (United States)

Bevan, Melody G; Asrani, Varsha M; Bharmal, Sakina; Wu, Landy M; Windsor, John A; Petrov, Maxim S

2017-06-01

Tolerance of oral food is an important criterion for hospital discharge in patients with acute pancreatitis. Patients who develop oral feeding intolerance have prolonged hospitalisation, use additional healthcare resources, and have impaired quality of life. This study aimed to quantify the incidence of oral feeding intolerance, the effect of confounders, and determine the best predictors of oral feeding intolerance. Clinical studies indexed in three electronic databases (EMBASE, MEDLINE, and the Cochrane Central Register of Controlled Trials) were reviewed. Incidence and predictor data were meta-analysed and possible confounders were investigated by meta-regression analysis. A total of 22 studies with 2024 patients met the inclusion criteria, 17 of which (with 1550 patients) were suitable for meta-analysis. The incidence of oral feeding intolerance was 16.3%, and was not affected by WHO region, age, sex, or aetiology of acute pancreatitis. Nine of the 22 studies investigated a total of 62 different predictors of oral feeding intolerance. Serum lipase level prior to refeeding, pleural effusions, (peri)pancreatic collections, Ranson score, and Balthazar score were found to be statistically significant in meta-analyses. Oral feeding intolerance affects approximately 1 in 6 patients with acute pancreatitis. Serum lipase levels of more than 2.5 times the upper limit of normal prior to refeeding is a potentially useful threshold to identify patients at high risk of developing oral feeding intolerance. Copyright © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Tunable meta-atom using liquid metal embedded in stretchable polymer

Energy Technology Data Exchange (ETDEWEB)

Liu, Peng; Yang, Siming; Wang, Qiugu; Jiang, Huawei; Song, Jiming; Dong, Liang, E-mail: ldong@iastate.edu [Department of Electrical and Computer Engineering, Iowa State University, Ames, Iowa 50011 (United States); Jain, Aditya [Department of Electrical and Computer Engineering, Iowa State University, Ames, Iowa 50011 (United States); Ames Laboratory, U.S. DOE and Department of Physics and Astronomy, Iowa State University, Ames, Iowa 50011 (United States); Koschny, Thomas; Soukoulis, Costas M. [Ames Laboratory, U.S. DOE and Department of Physics and Astronomy, Iowa State University, Ames, Iowa 50011 (United States)

2015-07-07

Reconfigurable metamaterials have great potential to alleviate complications involved in using passive metamaterials to realize emerging electromagnetic functions, such as dynamical filtering, sensing, and cloaking. This paper presents a new type of tunable meta-atoms in the X-band frequency range (8–12 GHz) toward reconfigurable metamaterials. The meta-atom is made of all flexible materials compliant to the surface of an interaction object. It uses a liquid metal-based split-ring resonator as its core constituent embedded in a highly flexible elastomer. We demonstrate that simple mechanical stretching of the meta-atom can lead to the great flexibility in reconfiguring its resonance frequency continuously over more than 70% of the X-band frequency range. The presented meta-atom technique provides a simple approach to dynamically tune response characteristics of metamaterials over a broad frequency range.

Tunable meta-atom using liquid metal embedded in stretchable polymer

International Nuclear Information System (INIS)

Liu, Peng; Yang, Siming; Wang, Qiugu; Jiang, Huawei; Song, Jiming; Dong, Liang; Jain, Aditya; Koschny, Thomas; Soukoulis, Costas M.

2015-01-01

Reconfigurable metamaterials have great potential to alleviate complications involved in using passive metamaterials to realize emerging electromagnetic functions, such as dynamical filtering, sensing, and cloaking. This paper presents a new type of tunable meta-atoms in the X-band frequency range (8–12 GHz) toward reconfigurable metamaterials. The meta-atom is made of all flexible materials compliant to the surface of an interaction object. It uses a liquid metal-based split-ring resonator as its core constituent embedded in a highly flexible elastomer. We demonstrate that simple mechanical stretching of the meta-atom can lead to the great flexibility in reconfiguring its resonance frequency continuously over more than 70% of the X-band frequency range. The presented meta-atom technique provides a simple approach to dynamically tune response characteristics of metamaterials over a broad frequency range

Meta-IDBA: a de Novo assembler for metagenomic data.

Science.gov (United States)

Peng, Yu; Leung, Henry C M; Yiu, S M; Chin, Francis Y L

2011-07-01

Next-generation sequencing techniques allow us to generate reads from a microbial environment in order to analyze the microbial community. However, assembling of a set of mixed reads from different species to form contigs is a bottleneck of metagenomic research. Although there are many assemblers for assembling reads from a single genome, there are no assemblers for assembling reads in metagenomic data without reference genome sequences. Moreover, the performances of these assemblers on metagenomic data are far from satisfactory, because of the existence of common regions in the genomes of subspecies and species, which make the assembly problem much more complicated. We introduce the Meta-IDBA algorithm for assembling reads in metagenomic data, which contain multiple genomes from different species. There are two core steps in Meta-IDBA. It first tries to partition the de Bruijn graph into isolated components of different species based on an important observation. Then, for each component, it captures the slight variants of the genomes of subspecies from the same species by multiple alignments and represents the genome of one species, using a consensus sequence. Comparison of the performances of Meta-IDBA and existing assemblers, such as Velvet and Abyss for different metagenomic datasets shows that Meta-IDBA can reconstruct longer contigs with similar accuracy. Meta-IDBA toolkit is available at our website http://www.cs.hku.hk/~alse/metaidba. chin@cs.hku.hk.

Does chocolate reduce blood pressure? A meta-analysis

Directory of Open Access Journals (Sweden)

Ried Karin

2010-06-01

Full Text Available Abstract Background Dark chocolate and flavanol-rich cocoa products have attracted interest as an alternative treatment option for hypertension, a known risk factor for cardiovascular disease. Previous meta-analyses concluded that cocoa-rich foods may reduce blood pressure. Recently, several additional trials have been conducted with conflicting results. Our study summarises current evidence on the effect of flavanol-rich cocoa products on blood pressure in hypertensive and normotensive individuals. Methods We searched Medline, Cochrane and international trial registries between 1955 and 2009 for randomised controlled trials investigating the effect of cocoa as food or drink compared with placebo on systolic and diastolic blood pressure (SBP/DBP for a minimum duration of 2 weeks. We conducted random effects meta-analysis of all studies fitting the inclusion criteria, as well as subgroup analysis by baseline blood pressure (hypertensive/normotensive. Meta-regression analysis explored the association between type of treatment, dosage, duration or baseline blood pressure and blood pressure outcome. Statistical significance was set at P Results Fifteen trial arms of 13 assessed studies met the inclusion criteria. Pooled meta-analysis of all trials revealed a significant blood pressure-reducing effect of cocoa-chocolate compared with control (mean BP change ± SE: SBP: -3.2 ± 1.9 mmHg, P = 0.001; DBP: -2.0 ± 1.3 mmHg, P = 0.003. However, subgroup meta-analysis was significant only for the hypertensive or prehypertensive subgroups (SBP: -5.0 ± 3.0 mmHg; P = 0.0009; DBP: -2.7 ± 2.2 mm Hg, P = 0.01, while BP was not significantly reduced in the normotensive subgroups (SBP: -1.6 ± 2.3 mmHg, P = 0.17; DBP: -1.3 ± 1.6 mmHg, P = 0.12. Nine trials used chocolate containing 50% to 70% cocoa compared with white chocolate or other cocoa-free controls, while six trials compared high- with low-flavanol cocoa products. Daily flavanol dosages ranged from 30

Using meta-analytic path analysis to test theoretical predictions in health behavior: An illustration based on meta-analyses of the theory of planned behavior.

Science.gov (United States)

Hagger, Martin S; Chan, Derwin K C; Protogerou, Cleo; Chatzisarantis, Nikos L D

2016-08-01

Synthesizing research on social cognitive theories applied to health behavior is an important step in the development of an evidence base of psychological factors as targets for effective behavioral interventions. However, few meta-analyses of research on social cognitive theories in health contexts have conducted simultaneous tests of theoretically-stipulated pattern effects using path analysis. We argue that conducting path analyses of meta-analytic effects among constructs from social cognitive theories is important to test nomological validity, account for mediation effects, and evaluate unique effects of theory constructs independent of past behavior. We illustrate our points by conducting new analyses of two meta-analyses of a popular theory applied to health behaviors, the theory of planned behavior. We conducted meta-analytic path analyses of the theory in two behavioral contexts (alcohol and dietary behaviors) using data from the primary studies included in the original meta-analyses augmented to include intercorrelations among constructs and relations with past behavior missing from the original analysis. Findings supported the nomological validity of the theory and its hypotheses for both behaviors, confirmed important model processes through mediation analysis, demonstrated the attenuating effect of past behavior on theory relations, and provided estimates of the unique effects of theory constructs independent of past behavior. Our analysis illustrates the importance of conducting a simultaneous test of theory-stipulated effects in meta-analyses of social cognitive theories applied to health behavior. We recommend researchers adopt this analytic procedure when synthesizing evidence across primary tests of social cognitive theories in health. Copyright © 2016 Elsevier Inc. All rights reserved.

Meta-GWAS Accuracy and Power (MetaGAP Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies.

Directory of Open Access Journals (Sweden)

Ronald de Vlaming

2017-01-01

Full Text Available Large-scale genome-wide association results are typically obtained from a fixed-effects meta-analysis of GWAS summary statistics from multiple studies spanning different regions and/or time periods. This approach averages the estimated effects of genetic variants across studies. In case genetic effects are heterogeneous across studies, the statistical power of a GWAS and the predictive accuracy of polygenic scores are attenuated, contributing to the so-called 'missing heritability'. Here, we describe the online Meta-GWAS Accuracy and Power (MetaGAP calculator (available at www.devlaming.eu which quantifies this attenuation based on a novel multi-study framework. By means of simulation studies, we show that under a wide range of genetic architectures, the statistical power and predictive accuracy provided by this calculator are accurate. We compare the predictions from the MetaGAP calculator with actual results obtained in the GWAS literature. Specifically, we use genomic-relatedness-matrix restricted maximum likelihood to estimate the SNP heritability and cross-study genetic correlation of height, BMI, years of education, and self-rated health in three large samples. These estimates are used as input parameters for the MetaGAP calculator. Results from the calculator suggest that cross-study heterogeneity has led to attenuation of statistical power and predictive accuracy in recent large-scale GWAS efforts on these traits (e.g., for years of education, we estimate a relative loss of 51-62% in the number of genome-wide significant loci and a relative loss in polygenic score R2 of 36-38%. Hence, cross-study heterogeneity contributes to the missing heritability.

MetaABC--an integrated metagenomics platform for data adjustment, binning and clustering.

Science.gov (United States)

Su, Chien-Hao; Hsu, Ming-Tsung; Wang, Tse-Yi; Chiang, Sufeng; Cheng, Jen-Hao; Weng, Francis C; Kao, Cheng-Yan; Wang, Daryi; Tsai, Huai-Kuang

2011-08-15

MetaABC is a metagenomic platform that integrates several binning tools coupled with methods for removing artifacts, analyzing unassigned reads and controlling sampling biases. It allows users to arrive at a better interpretation via series of distinct combinations of analysis tools. After execution, MetaABC provides outputs in various visual formats such as tables, pie and bar charts as well as clustering result diagrams. MetaABC source code and documentation are available at http://bits2.iis.sinica.edu.tw/MetaABC/ CONTACT: dywang@gate.sinica.edu.tw; hktsai@iis.sinica.edu.tw Supplementary data are available at Bioinformatics online.

Meta-analysis of randomized clinical trials in the era of individual patient data sharing.

Science.gov (United States)

Kawahara, Takuya; Fukuda, Musashi; Oba, Koji; Sakamoto, Junichi; Buyse, Marc

2018-06-01

Individual patient data (IPD) meta-analysis is considered to be a gold standard when the results of several randomized trials are combined. Recent initiatives on sharing IPD from clinical trials offer unprecedented opportunities for using such data in IPD meta-analyses. First, we discuss the evidence generated and the benefits obtained by a long-established prospective IPD meta-analysis in early breast cancer. Next, we discuss a data-sharing system that has been adopted by several pharmaceutical sponsors. We review a number of retrospective IPD meta-analyses that have already been proposed using this data-sharing system. Finally, we discuss the role of data sharing in IPD meta-analysis in the future. Treatment effects can be more reliably estimated in both types of IPD meta-analyses than with summary statistics extracted from published papers. Specifically, with rich covariate information available on each patient, prognostic and predictive factors can be identified or confirmed. Also, when several endpoints are available, surrogate endpoints can be assessed statistically. Although there are difficulties in conducting, analyzing, and interpreting retrospective IPD meta-analysis utilizing the currently available data-sharing systems, data sharing will play an important role in IPD meta-analysis in the future.

Meta-analysis for quantitative microbiological risk assessments and benchmarking data

NARCIS (Netherlands)

Besten, den H.M.W.; Zwietering, M.H.

2012-01-01

Meta-analysis studies are increasingly being conducted in the food microbiology area to quantitatively integrate the findings of many individual studies on specific questions or kinetic parameters of interest. Meta-analyses provide global estimates of parameters and quantify their variabilities, and

A systematic meta-review of evaluations of youth violence prevention programs: Common and divergent findings from 25 years of meta-analyses and systematic reviews☆

Science.gov (United States)

Matjasko, Jennifer L.; Vivolo-Kantor, Alana M.; Massetti, Greta M.; Holland, Kristin M.; Holt, Melissa K.; Cruz, Jason Dela

2018-01-01

Violence among youth is a pervasive public health problem. In order to make progress in reducing the burden of injury and mortality that result from youth violence, it is imperative to identify evidence-based programs and strategies that have a significant impact on violence. There have been many rigorous evaluations of youth violence prevention programs. However, the literature is large, and it is difficult to draw conclusions about what works across evaluations from different disciplines, contexts, and types of programs. The current study reviews the meta-analyses and systematic reviews published prior to 2009 that synthesize evaluations of youth violence prevention programs. This meta-review reports the findings from 37 meta-analyses and 15 systematic reviews; the included reviews were coded on measures of the social ecology, prevention approach, program type, and study design. A majority of the meta-analyses and systematic reviews were found to demonstrate moderate program effects. Meta-analyses yielded marginally smaller effect sizes compared to systematic reviews, and those that included programs targeting family factors showed marginally larger effects than those that did not. In addition, there are a wide range of individual/family, program, and study moderators of program effect sizes. Implications of these findings and suggestions for future research are discussed. PMID:29503594

Lung cancer risk in painters: a meta-analysis Risco de câncer de pulmão em pintores: uma meta-análise

Directory of Open Access Journals (Sweden)

Neela Guha

2011-08-01

Full Text Available We conducted a meta-analysis to quantitatively compare the association between occupation as a painter and the incidence or mortality from lung cancer. PubMed and the reference lists of pertinent publications were searched and reviewed. For the meta-analysis, we used data from 47 independent cohort, record linkage, and case-control studies (from a total of 74 reports, including > 11,000 incident cases or deaths from lung cancer among painters. Three authors independently abstracted data and assessed study quality. The summary relative risk (meta-RR, random effects for lung cancer in paint-ers was 1.35 [95% confidence interval (CI, 1.29-1.41; 47 studies] and 1.35 (95% CI, 1.21-1.51; 27 studies after controlling for smoking. The relative risk was higher in never-smokers (meta-RR = 2.00; 95% CI, 1.09-3.67; 3studies and persisted when restricted to studies that adjusted for other occupational exposures (meta-RR = 1.57; 95% CI, 1.21-2.04; 5 studies. These results support the conclusion that occupational exposures in painters are causally associated with the risk of lung cancer.Conduziu-se uma meta-análise para comparar quatitativamente a associação entre o trabalho de pintor e a incidência ou mortalidade por câncer de pulmão. PubMed e listas de referência de publicações pertinentes foram pesquisadas e revisadas. Para a análise, foram usados dados de 47 estudos de caso, coorte independente e ligação de dados (de um total de 74 relatórios, incluindo > 11 mil casos de incidentes ou morte por câncer de pulmão entre pintores. Três autores coletaram dados e avaliaram a qualidade de estudo. O risco relativo (meta-RR, efeitos aleatórios de câncer de pulmão em pintores foi de 1,35 [95% intervalo de confiança (IC, 1,29-1,41; 47 estudos] e 1,35 (95% IC, 1,21-1,51; 27 estudos depois de se destacar os fumantes. O risco relativo foi maior naqueles que nunca fumaram (meta-RR = 2.00; 95% CI, 1,09-3,67; 3 estudos e persistiu quanto restringido a

Signs of Meta-understanding

DEFF Research Database (Denmark)

Schrøder, Lise

2005-01-01

This paper is addressing aspects of usability and user needs at the meta-communicational level concerning how to facilitate an increased reuse of datasets related to buildings due to a Danish public geo-information management and infrastructure perspective. Lead by the goal of analyzing usability...

MetaRanker 2.0: a web server for prioritization of genetic variation data.

Science.gov (United States)

Pers, Tune H; Dworzyński, Piotr; Thomas, Cecilia Engel; Lage, Kasper; Brunak, Søren

2013-07-01

MetaRanker 2.0 is a web server for prioritization of common and rare frequency genetic variation data. Based on heterogeneous data sets including genetic association data, protein-protein interactions, large-scale text-mining data, copy number variation data and gene expression experiments, MetaRanker 2.0 prioritizes the protein-coding part of the human genome to shortlist candidate genes for targeted follow-up studies. MetaRanker 2.0 is made freely available at www.cbs.dtu.dk/services/MetaRanker-2.0.

Twenty years of meta-analyses in orthopaedic surgery: has quality kept up with quantity?

Science.gov (United States)

Dijkman, Bernadette G; Abouali, Jihad A K; Kooistra, Bauke W; Conter, Henry J; Poolman, Rudolf W; Kulkarni, Abhaya V; Tornetta, Paul; Bhandari, Mohit

2010-01-01

As the number of studies in the literature is increasing, orthopaedic surgeons highly depend on meta-analyses as their primary source of scientific evidence. The objectives of this review were to assess the scientific quality and number of published meta-analyses on orthopaedics-related topics over time. We conducted, in duplicate and independently, a systematic review of published meta-analyses in orthopaedics in the years 2005 and 2008 and compared them with a previous systematic review of meta-analyses from 1969 to 1999. A search of electronic databases (MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews) was performed to identify meta-analyses published in 2005 and 2008. We searched bibliographies and contacted content experts to identify additional relevant studies. Two investigators independently assessed the quality of the studies, using the Oxman and Guyatt index, and abstracted relevant data. We included forty-five and forty-four meta-analyses from 2005 and 2008, respectively. While the number of meta-analyses increased fivefold from 1999 to 2008, the mean quality score did not change significantly over time (p = 0.067). In the later years, a significantly lower proportion of meta-analyses had methodological flaws (56% in 2005 and 68% in 2008) compared with meta-analyses published prior to 2000 (88%) (p = 0.006). In 2005 and 2008, respectively, 18% and 30% of the meta-analyses had major to extensive flaws in their methodology. Studies from 2008 with positive conclusions used and described appropriate criteria for the validity assessment less often than did those with negative results. The use of random-effects and fixed-effects models as pooling methods became more popular toward 2008. Although the methodological quality of orthopaedic meta-analyses has increased in the past twenty years, a substantial proportion continues to show major to extensive flaws. As the number of published meta-analyses is increasing, a routine checklist for

Application software, domain-specific languages, and language design assistants

OpenAIRE

Heering, Jan

2000-01-01

textabstractWhile application software does the real work, domain-specific languages (DSLs) are tools to help produce it efficiently, and language design assistants in turn are meta-tools to help produce DSLs quickly. DSLs are already in wide use (HTML for web pages, Excel macros for spreadsheet applications, VHDL for hardware design, ...), but many more will be needed for both new as well as existing application domains. Language design assistants to help develop them currently exist only in...

Dropout from exercise randomized controlled trials among people with depression: A meta-analysis and meta regression.

Science.gov (United States)

Stubbs, Brendon; Vancampfort, Davy; Rosenbaum, Simon; Ward, Philip B; Richards, Justin; Soundy, Andrew; Veronese, Nicola; Solmi, Marco; Schuch, Felipe B

2016-01-15

Exercise has established efficacy in improving depressive symptoms. Dropouts from randomized controlled trials (RCT's) pose a threat to the validity of this evidence base, with dropout rates varying across studies. We conducted a systematic review and meta-analysis to investigate the prevalence and predictors of dropout rates among adults with depression participating in exercise RCT's. Three authors identified RCT's from a recent Cochrane review and conducted updated searches of major electronic databases from 01/2013 to 08/2015. We included RCT's of exercise interventions in people with depression (including major depressive disorder (MDD) and depressive symptoms) that reported dropout rates. A random effects meta-analysis and meta regression were conducted. Overall, 40 RCT's were included reporting dropout rates across 52 exercise interventions including 1720 people with depression (49.1 years (range=19-76 years), 72% female (range=0-100)). The trim and fill adjusted prevalence of dropout across all studies was 18.1% (95%CI=15.0-21.8%) and 17.2% (95%CI=13.5-21.7, N=31) in MDD only. In MDD participants, higher baseline depressive symptoms (β=0.0409, 95%CI=0.0809-0.0009, P=0.04) predicted greater dropout, whilst supervised interventions delivered by physiotherapists (β=-1.2029, 95%CI=-2.0967 to -0.3091, p=0.008) and exercise physiologists (β=-1.3396, 95%CI=-2.4478 to -0.2313, p=0.01) predicted lower dropout. A comparative meta-analysis (N=29) established dropout was lower in exercise than control conditions (OR=0.642, 95%CI=0.43-0.95, p=0.02). Exercise is well tolerated by people with depression and drop out in RCT's is lower than control conditions. Thus, exercise is a feasible treatment, in particular when delivered by healthcare professionals with specific training in exercise prescription. Copyright © 2015 Elsevier B.V. All rights reserved.

Psychotherapy for chronic major depression and dysthymia: A meta analysis.

NARCIS (Netherlands)

Cuijpers, P.; Straten, van A.; Schuurmans, J.; Oppen, van P.C.; Hollon, S.D.; Andersson, G.

2009-01-01

Abstract Although several studies have examined the effects of psychotherapy on chronic depression and dysthymia, no meta-analysis has been conducted to integrate results of these studies. We conducted a meta-analysis of 16 randomized trials examining the effects of psychotherapy on chronic

Chiral meta-atoms rotated by light

International Nuclear Information System (INIS)

Liu Mingkai; Powell, David A.; Shadrivov, Ilya V.

2012-01-01

We study the opto-mechanical properties of coupled chiral meta-atoms based on a pair of twisted split-ring resonators. By using a simple analytical model in conjunction with the Maxwell stress tensor, we capture insight into the mechanism and find that this structure can be used as a general prototype of subwavelength light-driven actuators over a wide range of frequencies. This coupled structure can provide a strong and tunable torque, and can support different opto-mechanical modes, including uniform rotation, periodically variable rotation and damped oscillations. Our results suggest that chiral meta-atoms are good candidates for creating sub-wavelength motors or wrenches controlled by light.

Chiral meta-atoms rotated by light

Science.gov (United States)

Liu, Mingkai; Powell, David A.; Shadrivov, Ilya V.

2012-07-01

We study the opto-mechanical properties of coupled chiral meta-atoms based on a pair of twisted split-ring resonators. By using a simple analytical model in conjunction with the Maxwell stress tensor, we capture insight into the mechanism and find that this structure can be used as a general prototype of subwavelength light-driven actuators over a wide range of frequencies. This coupled structure can provide a strong and tunable torque, and can support different opto-mechanical modes, including uniform rotation, periodically variable rotation and damped oscillations. Our results suggest that chiral meta-atoms are good candidates for creating sub-wavelength motors or wrenches controlled by light.

Metas académicas y estrategias de aprendizaje en estudiantes universitarios

Directory of Open Access Journals (Sweden)

Antonio Valle

Full Text Available Tomando en cuenta que no existe concordancia en la literatura entre los resultados de diferentes estudios respecto de la relevancia de la adopción de un tipo u otro de meta para el aprendizaje académico, en el presente artículo se estudia la relación entre los diferentes tipos de orientaciones motivacionales (metas de aprendizaje, metas de rendimiento y metas de evitación del trabajo y el uso de estrategias cognitivas y de autorregulación. En el trabajo participan 632 estudiantes universitarios de diversas titulaciones de la universidad española. Aunque el estudio es de tipo correlacional, los análisis de los datos obtenidos, corroborando estudios anteriores, aportan información de interés para la discusión del problema que se investigó, por ejemplo que sólo los niveles más altos de metas de aprendizaje se encuentran asociados con una mayor utilización de estrategias de aprendizaje. Son discutidas implicaciones educativas de estos datos

Metas académicas y estrategias de aprendizaje en estudiantes universitarios

Directory of Open Access Journals (Sweden)

Antonio Valle

Full Text Available Tomando en cuenta que no existe concordancia en la literatura entre los resultados de diferentes estudios respecto de la relevancia de la adopción de un tipo u otro de meta para el aprendizaje académico, en el presente artículo se estudia la relación entre los diferentes tipos de orientaciones motivacionales (metas de aprendizaje, metas de rendimiento y metas de evitación del trabajo y el uso de estrategias cognitivas y de autorregulación. En el trabajo participan 632 estudiantes universitarios de diversas titulaciones de la universidad española. Aunque el estudio es de tipo correlacional, los análisis de los datos obtenidos, corroborando estudios anteriores, aportan información de interés para la discusión del problema que se investigó, por ejemplo que sólo los niveles más altos de metas de aprendizaje se encuentran asociados con una mayor utilización de estrategias de aprendizaje. Son discutidas implicaciones educativas de estos datos.

Oxytocin Modulates Meta-Mood as a Function of Age and Sex

Directory of Open Access Journals (Sweden)

Natalie eEbner

2015-09-01

Full Text Available Attending to and understanding one’s own feelings are components of meta-mood and constitute important socio-affective skills across the entire lifespan. Growing evidence suggests a neuromodulatory role of the neuropeptide oxytocin on various socio-affective processes. Going beyond previous work that almost exclusively examined young men and perceptions of emotions in others, the current study investigated effects of intranasal oxytocin on meta-mood in young and older men and women. In a double-blind between-group design, participants were randomly assigned to self-administer either intranasal oxytocin or a placebo before responding to items from the Trait Meta-Mood Scale about attention to feelings and clarity of feelings. In contrast to older women, oxytocin relative to placebo increased attention to feelings in older men. Oxytocin relative to placebo enhanced meta-mood in young female participants but reduced it in older female participants. This pattern of findings supports an age- and sex-differential modulatory function of the neuropeptide oxytocin on meta-mood, possibly associated with neurobiological differences with age and sex.

Likelihood ratio meta-analysis: New motivation and approach for an old method.

Science.gov (United States)

Dormuth, Colin R; Filion, Kristian B; Platt, Robert W

2016-03-01

A 95% confidence interval (CI) in an updated meta-analysis may not have the expected 95% coverage. If a meta-analysis is simply updated with additional data, then the resulting 95% CI will be wrong because it will not have accounted for the fact that the earlier meta-analysis failed or succeeded to exclude the null. This situation can be avoided by using the likelihood ratio (LR) as a measure of evidence that does not depend on type-1 error. We show how an LR-based approach, first advanced by Goodman, can be used in a meta-analysis to pool data from separate studies to quantitatively assess where the total evidence points. The method works by estimating the log-likelihood ratio (LogLR) function from each study. Those functions are then summed to obtain a combined function, which is then used to retrieve the total effect estimate, and a corresponding 'intrinsic' confidence interval. Using as illustrations the CAPRIE trial of clopidogrel versus aspirin in the prevention of ischemic events, and our own meta-analysis of higher potency statins and the risk of acute kidney injury, we show that the LR-based method yields the same point estimate as the traditional analysis, but with an intrinsic confidence interval that is appropriately wider than the traditional 95% CI. The LR-based method can be used to conduct both fixed effect and random effects meta-analyses, it can be applied to old and new meta-analyses alike, and results can be presented in a format that is familiar to a meta-analytic audience. Copyright © 2016 Elsevier Inc. All rights reserved.

A linked GeoData map for enabling information access

Science.gov (United States)

Powell, Logan J.; Varanka, Dalia E.

2018-01-10

and pasting the data into a new file that follows the syntax of JSON–LD. Additionally, the Features file contained its own set of geometries, which was exported into a separate JSON–LD file along with its elevation value to form a fourth file, named “features-geo.json.” Extracted data from external files can be represented in HyperText Markup Language (HTML) path objects. The goal was to import multiple JSON–LD files using this approach.

Caffeine ingestion enhances Wingate performance: a meta-analysis.

Science.gov (United States)

Grgic, Jozo

2018-03-01

The positive effects of caffeine ingestion on aerobic performance are well-established; however, recent findings are suggesting that caffeine ingestion might also enhance components of anaerobic performance. A commonly used test of anaerobic performance and power output is the 30-second Wingate test. Several studies explored the effects of caffeine ingestion on Wingate performance, with equivocal findings. To elucidate this topic, this paper aims to determine the effects of caffeine ingestion on Wingate performance using meta-analytic statistical techniques. Following a search through PubMed/MEDLINE, Scopus, and SportDiscus ® , 16 studies were found meeting the inclusion criteria (pooled number of participants = 246). Random-effects meta-analysis of standardized mean differences (SMD) for peak power output and mean power output was performed. Study quality was assessed using the modified version of the PEDro checklist. Results of the meta-analysis indicated a significant difference (p = .005) between the placebo and caffeine trials on mean power output with SMD values of small magnitude (0.18; 95% confidence interval: 0.05, 0.31; +3%). The meta-analysis performed for peak power output indicated a significant difference (p = .006) between the placebo and caffeine trials (SMD = 0.27; 95% confidence interval: 0.08, 0.47 [moderate magnitude]; +4%). The results from the PEDro checklist indicated that, in general, studies are of good and excellent methodological quality. This meta-analysis adds on to the current body of evidence showing that caffeine ingestion can also enhance components of anaerobic performance. The results presented herein may be helpful for developing more efficient evidence-based recommendations regarding caffeine supplementation.

Spatial Bayesian latent factor regression modeling of coordinate-based meta-analysis data.

Science.gov (United States)

Montagna, Silvia; Wager, Tor; Barrett, Lisa Feldman; Johnson, Timothy D; Nichols, Thomas E

2018-03-01

Now over 20 years old, functional MRI (fMRI) has a large and growing literature that is best synthesised with meta-analytic tools. As most authors do not share image data, only the peak activation coordinates (foci) reported in the article are available for Coordinate-Based Meta-Analysis (CBMA). Neuroimaging meta-analysis is used to (i) identify areas of consistent activation; and (ii) build a predictive model of task type or cognitive process for new studies (reverse inference). To simultaneously address these aims, we propose a Bayesian point process hierarchical model for CBMA. We model the foci from each study as a doubly stochastic Poisson process, where the study-specific log intensity function is characterized as a linear combination of a high-dimensional basis set. A sparse representation of the intensities is guaranteed through latent factor modeling of the basis coefficients. Within our framework, it is also possible to account for the effect of study-level covariates (meta-regression), significantly expanding the capabilities of the current neuroimaging meta-analysis methods available. We apply our methodology to synthetic data and neuroimaging meta-analysis datasets. © 2017, The International Biometric Society.

Spatial Bayesian Latent Factor Regression Modeling of Coordinate-based Meta-analysis Data

Science.gov (United States)

Montagna, Silvia; Wager, Tor; Barrett, Lisa Feldman; Johnson, Timothy D.; Nichols, Thomas E.

2017-01-01

Summary Now over 20 years old, functional MRI (fMRI) has a large and growing literature that is best synthesised with meta-analytic tools. As most authors do not share image data, only the peak activation coordinates (foci) reported in the paper are available for Coordinate-Based Meta-Analysis (CBMA). Neuroimaging meta-analysis is used to 1) identify areas of consistent activation; and 2) build a predictive model of task type or cognitive process for new studies (reverse inference). To simultaneously address these aims, we propose a Bayesian point process hierarchical model for CBMA. We model the foci from each study as a doubly stochastic Poisson process, where the study-specific log intensity function is characterised as a linear combination of a high-dimensional basis set. A sparse representation of the intensities is guaranteed through latent factor modeling of the basis coefficients. Within our framework, it is also possible to account for the effect of study-level covariates (meta-regression), significantly expanding the capabilities of the current neuroimaging meta-analysis methods available. We apply our methodology to synthetic data and neuroimaging meta-analysis datasets. PMID:28498564

Early Versus Delayed Motion After Rotator Cuff Repair: A Systematic Review of Overlapping Meta-analyses.

Science.gov (United States)

Houck, Darby A; Kraeutler, Matthew J; Schuette, Hayden B; McCarty, Eric C; Bravman, Jonathan T

2017-10-01

Previous meta-analyses have been conducted to compare outcomes of early versus delayed motion after rotator cuff repair. To conduct a systematic review of overlapping meta-analyses comparing early versus delayed motion rehabilitation protocols after rotator cuff repair to determine which meta-analyses provide the best available evidence. Systematic review. A systematic review was performed by searching PubMed and Cochrane Library databases. Search terms included "rotator cuff repair," "early passive motion," "immobilization," "rehabilitation protocol," and "meta-analysis." Results were reviewed to determine study eligibility. Patient outcomes and structural healing were extracted from these meta-analyses. Meta-analysis quality was assessed using the Oxman-Guyatt and Quality of Reporting of Meta-analyses (QUOROM) systems. The Jadad decision algorithm was then used to determine which meta-analyses provided the best level of evidence. Seven meta-analyses containing a total of 5896 patients met the eligibility criteria (1 Level I evidence, 4 Level II evidence, 2 Level III evidence). None of these meta-analyses found immobilization to be superior to early motion; however, most studies suggested that early motion would increase range of motion (ROM), thereby reducing time of recovery. Three of these studies suggested that tear size contributed to the choice of rehabilitation to ensure proper healing of the shoulder. A study by Chan et al in 2014 received the highest QUOROM and Oxman-Guyatt scores, and therefore this meta-analysis appeared to have the highest level of evidence. Additionally, a study by Riboh and Garrigues in 2014 was selected as the highest quality study in this systematic review according to the Jadad decision algorithm. The current, best available evidence suggests that early motion improves ROM after rotator cuff repair but increases the risk of rotator cuff retear. Lower quality meta-analyses indicate that tear size may provide a better strategy in

Road safety effects of roundabouts: A meta-analysis.

Science.gov (United States)

Elvik, Rune

2017-02-01

This paper presents a meta-analysis of the road safety effects of converting junctions to roundabouts. 44 studies containing a total of 154 estimates of effect were included. Based on a meta-regression analysis, converting junctions to roundabouts is associated with a reduction of fatal accidents of about 65% and a reduction of injury accidents of about 40%. The mean effect on property-damage-only accidents is ambiguous. Summary estimates of effect are robust for fatal and injury accidents, but vary depending on the model of meta-analysis and the treatment of outlying data points for property-damage-only accidents. A trim-and-fill analysis suggests a weak tendency for publication bias, with modest influence on summary estimates of effect. It is concluded that roundabouts are very effective in reducing traffic fatalities. Copyright © 2016 Elsevier Ltd. All rights reserved.

Psychotherapy for chronic major depression and dysthymia: A meta analysis

NARCIS (Netherlands)

Cuijpers, P.; van Straten, A.; Schuurmans, J.; van Oppen, P.C.; Hollon, S.D.; Andersson, G.

2010-01-01

Although several studies have examined the effects of psychotherapy on chronic depression and dysthymia, no meta-analysis has been conducted to integrate results of these studies. We conducted a meta-analysis of 16 randomized trials examining the effects of psychotherapy on chronic depression and

Psychotherapy for chronic major depression and dysthymia: A meta analysis.

NARCIS (Netherlands)

Cuijpers, P.; van Straten, A.; Schuurmans, J.; van Oppen, P.C.; Hollon, S.D.; Andersson, G.

2009-01-01

Although several studies have examined the effects of psychotherapy on chronic depression and dysthymia, no meta-analysis has been conducted to integrate results of these studies. We conducted a meta-analysis of 16 randomized trials examining the effects of psychotherapy on chronic depression and

Dietary Assessment in the MetaCardis Study

DEFF Research Database (Denmark)

Verger, Eric O; Armstrong, Patrice; Nielsen, Trine

2017-01-01

Cardis FFQ and 3 consecutive self-administered web-based 24-hour dietary recalls (DRs). STATISTICAL ANALYSES PERFORMED: Several measures of validity of the French MetaCardis FFQ were evaluated: estimations of food groups, energy, and nutrient intakes from the DRs and the FFQ, Spearman and Pearson...... correlations, cross-classification, and Bland-Altman analyses. RESULTS: The French MetaCardis FFQ tended to report higher food, energy, and nutrient intakes compared with the DRs. Mean correlation coefficient was 0.429 for food, 0.460 for energy, 0.544 for macronutrients, 0.640 for alcohol, and 0...

Historical crime novels and meta-reflective aesthetics

DEFF Research Database (Denmark)

Agger, Gunhild; Jacobsen, Michael Hviid

2014-01-01

layers with a contemporary setting. The second will be represented by the ‘literary’, meta-reflective novel involving crime and investigation, but in untraditional ways where various levels of reflection form a part of the plot. In various ways, both contribute to highlight the influence of fictitious...... (2009) Kerstin Ekman continued her exploration of the act of crime, inspired by, re-writing and commenting on Hjalmar Söderberg’s Doctor Glas (1905). This novel represents a peculiar way of combining a historical setting with a meta-reflective strategy, which is strongly appealing. This strategy has...

A simple technique investigating baseline heterogeneity helped to eliminate potential bias in meta-analyses.

Science.gov (United States)

Hicks, Amy; Fairhurst, Caroline; Torgerson, David J

2018-03-01

To perform a worked example of an approach that can be used to identify and remove potentially biased trials from meta-analyses via the analysis of baseline variables. True randomisation produces treatment groups that differ only by chance; therefore, a meta-analysis of a baseline measurement should produce no overall difference and zero heterogeneity. A meta-analysis from the British Medical Journal, known to contain significant heterogeneity and imbalance in baseline age, was chosen. Meta-analyses of baseline variables were performed and trials systematically removed, starting with those with the largest t-statistic, until the I 2 measure of heterogeneity became 0%, then the outcome meta-analysis repeated with only the remaining trials as a sensitivity check. We argue that heterogeneity in a meta-analysis of baseline variables should not exist, and therefore removing trials which contribute to heterogeneity from a meta-analysis will produce a more valid result. In our example none of the overall outcomes changed when studies contributing to heterogeneity were removed. We recommend routine use of this technique, using age and a second baseline variable predictive of outcome for the particular study chosen, to help eliminate potential bias in meta-analyses. Copyright © 2017 Elsevier Inc. All rights reserved.

Incorporating uncertainty regarding applicability of evidence from meta-analyses into clinical decision making.

Science.gov (United States)

Kriston, Levente; Meister, Ramona

2014-03-01

Judging applicability (relevance) of meta-analytical findings to particular clinical decision-making situations remains challenging. We aimed to describe an evidence synthesis method that accounts for possible uncertainty regarding applicability of the evidence. We conceptualized uncertainty regarding applicability of the meta-analytical estimates to a decision-making situation as the result of uncertainty regarding applicability of the findings of the trials that were included in the meta-analysis. This trial-level applicability uncertainty can be directly assessed by the decision maker and allows for the definition of trial inclusion probabilities, which can be used to perform a probabilistic meta-analysis with unequal probability resampling of trials (adaptive meta-analysis). A case study with several fictitious decision-making scenarios was performed to demonstrate the method in practice. We present options to elicit trial inclusion probabilities and perform the calculations. The result of an adaptive meta-analysis is a frequency distribution of the estimated parameters from traditional meta-analysis that provides individually tailored information according to the specific needs and uncertainty of the decision maker. The proposed method offers a direct and formalized combination of research evidence with individual clinical expertise and may aid clinicians in specific decision-making situations. Copyright © 2014 Elsevier Inc. All rights reserved.

A SQL-Database Based Meta-CASE System and its Query Subsystem

Science.gov (United States)

Eessaar, Erki; Sgirka, Rünno

Meta-CASE systems simplify the creation of CASE (Computer Aided System Engineering) systems. In this paper, we present a meta-CASE system that provides a web-based user interface and uses an object-relational database system (ORDBMS) as its basis. The use of ORDBMSs allows us to integrate different parts of the system and simplify the creation of meta-CASE and CASE systems. ORDBMSs provide powerful query mechanism. The proposed system allows developers to use queries to evaluate and gradually improve artifacts and calculate values of software measures. We illustrate the use of the systems by using SimpleM modeling language and discuss the use of SQL in the context of queries about artifacts. We have created a prototype of the meta-CASE system by using PostgreSQL™ ORDBMS and PHP scripting language.

Aprendizaje autorregulado, metas académicas y rendimiento en evaluaciones de estudiantes universitarios

Directory of Open Access Journals (Sweden)

Marcela Valencia Serrano

2013-01-01

Full Text Available Objetivo. Explorar la relación entre aprendizaje autorregulado, metas académicas y rendimiento en una evaluación académica de ocho estudiantes universitarias. Método. Se realizó una entrevista semi- estructurada, una observación directa de una sesión de estudio y protocolos verbales durante y después de la sesión. Resultados. En relación con las metas académicas, se encontró que tres estudiantes tuvieron u na única orientación a metas de dominio por aproximación, mientras que cinco orien taron a múltiples metas académicas. Respecto al aprendizaje autorregulado, se encontraron estudiantes con b ajos y altos niveles. En la relación entre aprendizaje autorregulado, metas académicas y rendimiento en la evaluación fue posible identificar tres grupos de estudiantes: (a altos niveles de autorregulación y orientación única a metas de dominio por aproximación, (b bajos niveles de autorregulación y múltipl e orientación a metas de dominio y ejecución en tendencias de aproximación y evitación, y (c variaciones en el nivel de autorregulación con múltiple orientación a metas académicas. Todas las estudiantes obtuvieron cali ficaciones aprobatorias en la evaluación, independientemente de su nivel de autorregulación y de la orientaci ón a metas académicas. Conclusión. El abordaje procedimental del aprendizaje autorregulado, en función de las metas académicas, permitió obtener información relevante para la comprensión de este proceso, por lo que se recomienda seguir realizando este tipo de estudios para dar cuenta de los diferentes fu ncionamientos de las estudiantes universitarias en tiempo real, de sus variaciones y relación con otros aspectos motivacionales involucrados en sus procesos de aprendizaje.

Informational institutions in the agrifood sector: meta-information and meta-governance of environmental sustainability

NARCIS (Netherlands)

Ge, L.; Brewster, Christopher

2016-01-01

In the agrifood sector, the explosive increase in information about environmental sustainability, often in uncoordinated information systems, has created a new form of ignorance (‘meta-ignorance’) that diminishes the effectiveness of information on decision-makers. Flows of information are governed

A Microsoft-Excel-based tool for running and critically appraising network meta-analyses—an overview and application of NetMetaXL

OpenAIRE

Brown, Stephen; Hutton, Brian; Clifford, Tammy; Coyle, Doug; Grima, Daniel; Wells, George; Cameron, Chris

2014-01-01

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. BACKGROUND: The use of network meta-analysis has increased dramatically in recent years. WinBUGS, a freely available Bayesian software package, has been the most widely used software package to conduct network meta-ana...

Meta-synthesis of qualitative research: the challenges and opportunities.

Science.gov (United States)

Mohammed, Mohammed A; Moles, Rebekah J; Chen, Timothy F

2016-06-01

Synthesis of qualitative studies is an emerging area that has been gaining more interest as an important source of evidence for improving health care policy and practice. In the last decade there have been numerous attempts to develop methods of aggregating and synthesizing qualitative data. Although numerous empirical qualitative studies have been published about different aspects of health care research, to date, the aggregation and syntheses of these data has not been commonly reported, particularly in pharmacy practice related research. This paper describes different methods of conducting meta-synthesis and provides an overview of selected common methods. The paper also emphasizes the challenges and opportunities associated with conducting meta-synthesis and highlights the importance of meta-synthesis in informing practice, policy and research.

Does chocolate reduce blood pressure? A meta-analysis.

Science.gov (United States)

Ried, Karin; Sullivan, Thomas; Fakler, Peter; Frank, Oliver R; Stocks, Nigel P

2010-06-28

Dark chocolate and flavanol-rich cocoa products have attracted interest as an alternative treatment option for hypertension, a known risk factor for cardiovascular disease. Previous meta-analyses concluded that cocoa-rich foods may reduce blood pressure. Recently, several additional trials have been conducted with conflicting results. Our study summarises current evidence on the effect of flavanol-rich cocoa products on blood pressure in hypertensive and normotensive individuals. We searched Medline, Cochrane and international trial registries between 1955 and 2009 for randomised controlled trials investigating the effect of cocoa as food or drink compared with placebo on systolic and diastolic blood pressure (SBP/DBP) for a minimum duration of 2 weeks. We conducted random effects meta-analysis of all studies fitting the inclusion criteria, as well as subgroup analysis by baseline blood pressure (hypertensive/normotensive). Meta-regression analysis explored the association between type of treatment, dosage, duration or baseline blood pressure and blood pressure outcome. Statistical significance was set at P chocolate compared with control (mean BP change +/- SE: SBP: -3.2 +/- 1.9 mmHg, P = 0.001; DBP: -2.0 +/- 1.3 mmHg, P = 0.003). However, subgroup meta-analysis was significant only for the hypertensive or prehypertensive subgroups (SBP: -5.0 +/- 3.0 mmHg; P = 0.0009; DBP: -2.7 +/- 2.2 mm Hg, P = 0.01), while BP was not significantly reduced in the normotensive subgroups (SBP: -1.6 +/- 2.3 mmHg, P = 0.17; DBP: -1.3 +/- 1.6 mmHg, P = 0.12). Nine trials used chocolate containing 50% to 70% cocoa compared with white chocolate or other cocoa-free controls, while six trials compared high- with low-flavanol cocoa products. Daily flavanol dosages ranged from 30 mg to 1000 mg in the active treatment groups, and interventions ran for 2 to 18 weeks. Meta-regression analysis found study design and type of control to be borderline significant but possibly indirect predictors

What Makes a Good Educator? The Relevance of Meta Programmes

Science.gov (United States)

Brown, Nigel

2004-01-01

This paper reports the results of a qualitative study which explores the relevance of meta programmes to students' perceptions of teaching quality. Meta programmes are a model of personality preferences from the discipline of Neuro Linguistic Programming (NLP). Research into teaching effectiveness indicates that students rate as important "hygiene…

Values of natural and human-made wetlands: A meta-analysis

NARCIS (Netherlands)

Ghermandi, A.; van den Bergh, J.C.J.M.; Brander, L.M.; de Groot, H.L.F.; Nunes, P.A.L.D.

2010-01-01

The values of goods and services provided by wetland ecosystems are examined through a meta-analysis of an expanded database of wetland value estimates and with a focus on human-made wetlands. This study extends and improves upon previous meta-analyses of the wetland valuation literature in terms of

Cholelithiasis, cholecystectomy and risk of hepatocellular carcinoma: A meta-analysis

Directory of Open Access Journals (Sweden)

Lingyun Guo

2014-01-01

Full Text Available Available evidence of the relationship between cholelithiasis, cholecystectomy, and risk of liver cancer and hence we conducted a meta-analysis to investigate the relationships. PubMed, EMBASE, and ISI Web of Knowledge were searched to identify all published cohort studies and case-control studies that evaluated the relationships of cholelithiasis, cholecystectomy and risk of liver cancer and single-cohort studies which evaluated the incidence of liver cancer among patients who understood cholecystectomy (up to February 2013. Comprehensive meta-analysis software was used for meta-analysis. A total of 11 observational studies (six cohort studies and five case-control studies were included in this meta-analysis. The result from meta-analysis showed that cholecystectomy (risk ratio [RR]: 1.59, 95% confidence interval [CI]: 1.01-2.51, I2 = 72% and cholecystolithiasis (RR: 5.40, 95% CI: 3.69-7.89, I2 = 93% was associated with more liver cancer, especially for intrahepatic cholangiocarcinoma (ICC (cholecystectomy: RR: 3.51, 95% CI: 1.84-6.71, I2 = 26%; cholecystolithiasis: RR: 11.06, 95% CI: 6.99-17.52, I2 = 0%. The pooled standardized incidence rates (SIR of liver cancer in patients who understood cholecystectomy showed cholecystectomy might increase the incidence of liver cancer (SIR: 1.57, 95% CI: 1.13-2.20, I2 = 15%. Based on the results of the meta-analysis, cholecystectomy and cholecystolithiasis seemed to be involved in the development of liver cancer, especially for ICC. However, most available studies were case-control studies and short-term cohort studies, so the future studies should more long-term cohort studies should be well-conducted to evaluate the long-term relationship.

Longitudinal analysis of meta-analysis literatures in the database of ISI Web of Science.

Science.gov (United States)

Zhu, Changtai; Jiang, Ting; Cao, Hao; Sun, Wenguang; Chen, Zhong; Liu, Jinming

2015-01-01

The meta-analysis is regarded as an important evidence for making scientific decision. The database of ISI Web of Science collected a great number of high quality literatures including meta-analysis literatures. However, it is significant to understand the general characteristics of meta-analysis literatures to outline the perspective of meta-analysis. In this present study, we summarized and clarified some features on these literatures in the database of ISI Web of Science. We retrieved the meta-analysis literatures in the database of ISI Web of Science including SCI-E, SSCI, A&HCI, CPCI-S, CPCI-SSH, CCR-E, and IC. The annual growth rate, literature category, language, funding, index citation, agencies and countries/territories of the meta-analysis literatures were analyzed, respectively. A total of 95,719 records, which account for 0.38% (99% CI: 0.38%-0.39%) of all literatures, were found in the database. From 1997 to 2012, the annual growth rate of meta-analysis literatures was 18.18%. The literatures involved in many categories, languages, fundings, citations, publication agencies, and countries/territories. Interestingly, the index citation frequencies of the meta-analysis were significantly higher than that of other type literatures such as multi-centre study, randomize controlled trial, cohort study, case control study, and cases report (Panalysis has been becoming more and more prominent in recent years. In future, in order to promote the validity of meta-analysis, the CONSORT and PRISMA standard should be continuously popularized in the field of evidence-based medicine.

Applying the Business Process and Practice Alignment Meta-model: Daily Practices and Process Modelling

Directory of Open Access Journals (Sweden)

Ventura Martins Paula

2017-03-01

Full Text Available Background: Business Process Modelling (BPM is one of the most important phases of information system design. Business Process (BP meta-models allow capturing informational and behavioural aspects of business processes. Unfortunately, standard BP meta-modelling approaches focus just on process description, providing different BP models. It is not possible to compare and identify related daily practices in order to improve BP models. This lack of information implies that further research in BP meta-models is needed to reflect the evolution/change in BP. Considering this limitation, this paper introduces a new BP meta-model designed by Business Process and Practice Alignment Meta-model (BPPAMeta-model. Our intention is to present a meta-model that addresses features related to the alignment between daily work practices and BP descriptions. Objectives: This paper intends to present a metamodel which is going to integrate daily work information into coherent and sound process definitions. Methods/Approach: The methodology employed in the research follows a design-science approach. Results: The results of the case study are related to the application of the proposed meta-model to align the specification of a BP model with work practices models. Conclusions: This meta-model can be used within the BPPAM methodology to specify or improve business processes models based on work practice descriptions.

MADAM - An open source meta-analysis toolbox for R and Bioconductor

Directory of Open Access Journals (Sweden)

Graber Armin

2010-03-01

Full Text Available Abstract Background Meta-analysis is a major theme in biomedical research. In the present paper we introduce a package for R and Bioconductor that provides useful tools for performing this type of work. One idea behind the development of MADAM was that many meta-analysis methods, which are available in R, are not able to use the capacities of parallel computing yet. In this first version, we implemented one meta-analysis method in such a parallel manner. Additionally, we provide tools for combining the results from a set of methods in an ensemble approach. Functionality for visualization of results is also provided. Results The presented package enables the carrying out of meta-analysis either by providing functions directly or by wrapping them to existing implementations. Overall, five different meta-analysis methods are now usable through MADAM, along with another three methods for combining the corresponding results. Visualizing the results is eased by three included functions. For developing and testing meta-analysis methods, a mock up data generator is integrated. Conclusions The use of MADAM enables a user to focus on one package, in turn enabling them to work with the same data types across a set of methods. By making use of the snow package, MADAM can be made compatible with an existing parallel computing infrastructure. MADAM is open source and freely available within CRAN http://cran.r-project.org.

MetaStorm: A Public Resource for Customizable Metagenomics Annotation.

Directory of Open Access Journals (Sweden)

Gustavo Arango-Argoty

Full Text Available Metagenomics is a trending research area, calling for the need to analyze large quantities of data generated from next generation DNA sequencing technologies. The need to store, retrieve, analyze, share, and visualize such data challenges current online computational systems. Interpretation and annotation of specific information is especially a challenge for metagenomic data sets derived from environmental samples, because current annotation systems only offer broad classification of microbial diversity and function. Moreover, existing resources are not configured to readily address common questions relevant to environmental systems. Here we developed a new online user-friendly metagenomic analysis server called MetaStorm (http://bench.cs.vt.edu/MetaStorm/, which facilitates customization of computational analysis for metagenomic data sets. Users can upload their own reference databases to tailor the metagenomics annotation to focus on various taxonomic and functional gene markers of interest. MetaStorm offers two major analysis pipelines: an assembly-based annotation pipeline and the standard read annotation pipeline used by existing web servers. These pipelines can be selected individually or together. Overall, MetaStorm provides enhanced interactive visualization to allow researchers to explore and manipulate taxonomy and functional annotation at various levels of resolution.

MetaStorm: A Public Resource for Customizable Metagenomics Annotation.

Science.gov (United States)

Arango-Argoty, Gustavo; Singh, Gargi; Heath, Lenwood S; Pruden, Amy; Xiao, Weidong; Zhang, Liqing

2016-01-01

Metagenomics is a trending research area, calling for the need to analyze large quantities of data generated from next generation DNA sequencing technologies. The need to store, retrieve, analyze, share, and visualize such data challenges current online computational systems. Interpretation and annotation of specific information is especially a challenge for metagenomic data sets derived from environmental samples, because current annotation systems only offer broad classification of microbial diversity and function. Moreover, existing resources are not configured to readily address common questions relevant to environmental systems. Here we developed a new online user-friendly metagenomic analysis server called MetaStorm (http://bench.cs.vt.edu/MetaStorm/), which facilitates customization of computational analysis for metagenomic data sets. Users can upload their own reference databases to tailor the metagenomics annotation to focus on various taxonomic and functional gene markers of interest. MetaStorm offers two major analysis pipelines: an assembly-based annotation pipeline and the standard read annotation pipeline used by existing web servers. These pipelines can be selected individually or together. Overall, MetaStorm provides enhanced interactive visualization to allow researchers to explore and manipulate taxonomy and functional annotation at various levels of resolution.

Conducting a meta-ethnography of qualitative literature: lessons learnt.

Science.gov (United States)

Atkins, Salla; Lewin, Simon; Smith, Helen; Engel, Mark; Fretheim, Atle; Volmink, Jimmy

2008-04-16

Qualitative synthesis has become more commonplace in recent years. Meta-ethnography is one of several methods for synthesising qualitative research and is being used increasingly within health care research. However, many aspects of the steps in the process remain ill-defined. We utilized the seven stages of the synthesis process to synthesise qualitative research on adherence to tuberculosis treatment. In this paper we discuss the methodological and practical challenges faced; of particular note are the methods used in our synthesis, the additional steps that we found useful in clarifying the process, and the key methodological challenges encountered in implementing the meta-ethnographic approach. The challenges included shaping an appropriate question for the synthesis; identifying relevant studies; assessing the quality of the studies; and synthesising findings across a very large number of primary studies from different contexts and research traditions. We offer suggestions that may assist in undertaking meta-ethnographies in the future. Meta-ethnography is a useful method for synthesising qualitative research and for developing models that interpret findings across multiple studies. Despite its growing use in health research, further research is needed to address the wide range of methodological and epistemological questions raised by the approach.

MetaStorm: A Public Resource for Customizable Metagenomics Annotation

Science.gov (United States)

Arango-Argoty, Gustavo; Singh, Gargi; Heath, Lenwood S.; Pruden, Amy; Xiao, Weidong; Zhang, Liqing

2016-01-01

Metagenomics is a trending research area, calling for the need to analyze large quantities of data generated from next generation DNA sequencing technologies. The need to store, retrieve, analyze, share, and visualize such data challenges current online computational systems. Interpretation and annotation of specific information is especially a challenge for metagenomic data sets derived from environmental samples, because current annotation systems only offer broad classification of microbial diversity and function. Moreover, existing resources are not configured to readily address common questions relevant to environmental systems. Here we developed a new online user-friendly metagenomic analysis server called MetaStorm (http://bench.cs.vt.edu/MetaStorm/), which facilitates customization of computational analysis for metagenomic data sets. Users can upload their own reference databases to tailor the metagenomics annotation to focus on various taxonomic and functional gene markers of interest. MetaStorm offers two major analysis pipelines: an assembly-based annotation pipeline and the standard read annotation pipeline used by existing web servers. These pipelines can be selected individually or together. Overall, MetaStorm provides enhanced interactive visualization to allow researchers to explore and manipulate taxonomy and functional annotation at various levels of resolution. PMID:27632579

Hydropower externalities: A meta-analysis

International Nuclear Information System (INIS)

Mattmann, Matteo; Logar, Ivana; Brouwer, Roy

2016-01-01

This paper presents a meta-analysis of existing research related to the economic valuation of the external effects of hydropower. A database consisting of 81 observations derived from 29 studies valuing the non-market impacts of hydropower electricity generation is constructed with the main aim to quantify and explain the economic values for positive and negative hydropower externalities. Different meta-regression model specifications are used to test the robustness of significant determinants of non-market values, including different types of hydropower impacts. The explanatory and predictive power of the estimated models is relatively high. Whilst controlling for sample and study characteristics, we find significant evidence for public aversion towards deteriorations of landscape, vegetation and wildlife caused by hydropower projects. There is however only weak evidence of willingness to pay for mitigating these effects. The main positive externality of hydropower generation, the avoidance of greenhouse gas emission, positively influences welfare estimates when combined with the share of hydropower in national energy production. Sensitivity to scope is detected, but not linked to specific externalities or non-market valuation methods. - Highlights: • A global meta-analysis of valuation studies of hydropower externalities is presented. • Positive and negative externalities are distinguished. • Welfare losses due to environmental deteriorations outweigh gains of GHG reductions. • There is only weak evidence of public WTP for mitigating negative externalities. • The non-market values of hydropower externalities are sensitive to scope.

Group boundary permeability moderates the effect of a dependency meta-stereotype on help-seeking behaviour.

Science.gov (United States)

Zhang, Lange; Kou, Yu; Zhao, Yunlong; Fu, Xinyuan

2016-08-01

Previous studies have found that when low-status group members are aware that their in-group is stereotyped as dependent by a specific out-group (i.e. a dependency meta-stereotype is salient), they are reluctant to seek help from the high-status out-group to avoid confirming the negative meta-stereotype. However, it is unclear whether low-status group members would seek more help in the context of a salient dependency meta-stereotype when there is low (vs. high) group boundary permeability. Therefore, we conducted two experiments to examine the moderating effect of permeability on meta-stereotype confirmation with a real group. In study 1, we manipulated the salience of the dependency meta-stereotype, measured participants' perceived permeability and examined their help-seeking behaviour in a real-world task. Participants who perceived low permeability sought more help when the meta-stereotype was salient (vs. not salient), whereas participants who perceived high permeability sought the same amount of help across conditions. In study 2, we manipulated the permeability levels and measured the dependency meta-stereotype. Participants who endorsed a high-dependency meta-stereotype sought more help than participants who endorsed a low-dependency meta-stereotype; this effect was particularly strong in the low-permeability condition. The implications of these results for social mobility and intergroup helping are discussed. © 2015 International Union of Psychological Science.

Dielectric Meta-Holograms Enabled with Dual Magnetic Resonances in Visible Light.

Science.gov (United States)

Li, Zile; Kim, Inki; Zhang, Lei; Mehmood, Muhammad Q; Anwar, Muhammad S; Saleem, Murtaza; Lee, Dasol; Nam, Ki Tae; Zhang, Shuang; Luk'yanchuk, Boris; Wang, Yu; Zheng, Guoxing; Rho, Junsuk; Qiu, Cheng-Wei

2017-09-26

Efficient transmission-type meta-holograms have been demonstrated using high-index dielectric nanostructures based on Huygens' principle. It is crucial that the geometry size of building blocks be judiciously optimized individually for spectral overlap of electric and magnetic dipoles. In contrast, reflection-type meta-holograms using the metal/insulator/metal scheme and geometric phase can be readily achieved with high efficiency and small thickness. Here, we demonstrate a general platform for design of dual magnetic resonance based meta-holograms based on the geometric phase using silicon nanostructures that are quarter wavelength thick for visible light. Significantly, the projected holographic image can be unambiguously observed without a receiving screen even under the illumination of natural light. Within the well-developed semiconductor industry, our ultrathin magnetic resonance-based meta-holograms may have promising applications in anticounterfeiting and information security.

Effectiveness of Mobile Devices on Vocabulary Learning: A Meta-Analysis

Science.gov (United States)

Mahdi, Hassan Saleh

2018-01-01

Mobile devices are considered as the most widely used information and communication technologies. They have provided great advantages in language learning. This study reports a meta-analysis of the effectiveness of using mobile devices on vocabulary learning. A meta-analysis was conducted on research that compared the outcomes from students…

Mean-field theory of meta-learning

International Nuclear Information System (INIS)

Plewczynski, Dariusz

2009-01-01

We discuss here the mean-field theory for a cellular automata model of meta-learning. Meta-learning is the process of combining outcomes of individual learning procedures in order to determine the final decision with higher accuracy than any single learning method. Our method is constructed from an ensemble of interacting, learning agents that acquire and process incoming information using various types, or different versions, of machine learning algorithms. The abstract learning space, where all agents are located, is constructed here using a fully connected model that couples all agents with random strength values. The cellular automata network simulates the higher level integration of information acquired from the independent learning trials. The final classification of incoming input data is therefore defined as the stationary state of the meta-learning system using simple majority rule, yet the minority clusters that share the opposite classification outcome can be observed in the system. Therefore, the probability of selecting a proper class for a given input data, can be estimated even without the prior knowledge of its affiliation. The fuzzy logic can be easily introduced into the system, even if learning agents are built from simple binary classification machine learning algorithms by calculating the percentage of agreeing agents

Systematic review with meta-analysis

DEFF Research Database (Denmark)

Roda, G; Narula, N; Pinotti, R

2017-01-01

and meta-analysis of epidemiological studies reporting on extension of ulcerative colitis to determine frequency of disease extension in patients with limited ulcerative colitis at diagnosis. METHODS: We performed a systematic literature search to identify studies on disease extension of ulcerative colitis...... (UC) and predictors of disease progression. RESULTS: Overall, 41 studies were eligible for systematic review but only 30 for meta-analysis. The overall pooled frequency of UC extension was 22.8% with colonic extension being 17.8% at 5 years and 31% at 10 years. Extension was 17.8% (95% CI 11...... in patients from North America (37.8%) than from Europe (19.6%) (Pmeta-analysis, approximately one quarter of patients with limited UC extend over time with most extension occurring during the first 10 years. Rate of extension depends on age at diagnosis and geographic origin...

Network meta-analyses performed by contracting companies and commissioned by industry

NARCIS (Netherlands)

Schuit, Ewoud; Ioannidis, John P A

2016-01-01

Background: Industry commissions contracting companies to perform network meta-analysis for health technology assessment (HTA) and reimbursement submissions. Our objective was to estimate the number of network meta-analyses performed by consulting companies contracted by industry, to assess whether

Memory and Obstructive Sleep Apnea: A Meta-Analysis

Science.gov (United States)

Wallace, Anna; Bucks, Romola S.

2013-01-01

Study Objectives: To examine episodic memory performance in individuals with obstructive sleep apnea (OSA). Design Meta-analysis was used to synthesize results from individual studies examining the impact of OSA on episodic memory performance. The performance of individuals with OSA was compared to healthy controls or normative data. Participants Forty-two studies were included, comprising 2,294 adults with untreated OSA and 1,364 healthy controls. Studies that recorded information about participants at baseline prior to treatment interventions were included in the analysis. Measurements Participants were assessed with tasks that included a measure of episodic memory: immediate recall, delayed recall, learning, and/or recognition memory. Results: The results of the meta-analyses provide evidence that individuals with OSA are significantly impaired when compared to healthy controls on verbal episodic memory (immediate recall, delayed recall, learning, and recognition) and visuo-spatial episodic memory (immediate and delayed recall), but not visual immediate recall or visuo-spatial learning. When patients were compared to norms, negative effects of OSA were found only in verbal immediate and delayed recall. Conclusions: This meta-analysis contributes to understanding of the nature of episodic memory deficits in individuals with OSA. Impairments to episodic memory are likely to affect the daily functioning of individuals with OSA. Citation Wallace A; Bucks RS. Memory and obstructive sleep apnea: a meta-analysis. SLEEP 2013;36(2):203-220. PMID:23372268

Neurological Soft Signs in Schizophrenia: A Meta-analysis

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Chan, Raymond C. K.; Xu, Ting; Heinrichs, R. Walter; Yu, Yue; Wang, Ya

2010-01-01

Background: Neurological soft signs (NSS) are hypothesized as candidate endophenotypes for schizophrenia, but their prevalence and relations with clinical and demographic data are unknown. The authors undertook a quantification (meta-analysis) of the published literature on NSS in patients with schizophrenia and healthy controls. A systematic search was conducted for published articles reporting NSS and related data using standard measures in schizophrenia and healthy comparison groups. Method: A systematic search was conducted for published articles reporting data on the prevalence of NSS in schizophrenia using standard clinical rating scales and healthy comparison groups. Meta-analyses were performed using the Comprehensive Meta-analysis software package. Effect sizes (Cohen d) indexing the difference between schizophrenic patients and the healthy controls were calculated on the basis of reported statistics. Potential moderator variables evaluated included age of patient samples, level of education, sample sex proportions, medication doses, and negative and positive symptoms. Results: A total of 33 articles met inclusion criteria for the meta-analysis. A large and reliable group difference (Cohen d) indicated that, on average, a majority of patients (73%) perform outside the range of healthy subjects on aggregate NSS measures. Cognitive performance and positive and negative symptoms share 2%–10% of their variance with NSS. Conclusions: NSS occur in a majority of the schizophrenia patient population and are largely distinct from symptomatic and cognitive features of the illness. PMID:19377058

Conceptual design studies for the liquid metal target META:LIC

International Nuclear Information System (INIS)

Class, A.G.; Fazio, C.; Fetzer, J.R.; Gordeev, S.

2014-01-01

When the construction of ESS (European Spallation Source) in Sweden was initiated, the target station concept selection group decided to reevaluate a variety of target designs to respect new developments in their selection process. The META:LIC (MEgawatt TArget:Lead bIsmuth Cooled) target concept was developed following an extensive analysis of existing and new proposed designs and reached the level of proof of principle within only 2 years. ESS selected META:LIC as comparative target option for licensing purposes during the design update phase of ESS. The present work describes the design motivation of META:LIC referring to properties and design features of other targets. Therefore, META:LIC design is an evolutionary target which incorporates the extensive experience of liquid metal targets. The modular LBE (Lead Bismuth Eutectic) target concept with focus on the target module is introduced. Both, a window target option for the start of operation and a windowless option with extended lifetime are foreseen. Thermohydraulic simulations show that adequate window cooling can be realized. The stability of the free surface in the windowless option has been shown. Robust target module instrumentation based on free surface levels and the MEGAPIE experience is proposed for target control. Since the META:LIC concept foresees a horizontal extraction for both moderators and target from the monolith a safety concept based on the SNS and JSNS experience is proposed

Affective and cognitive meta-bases of attitudes: Unique effects on information interest and persuasion.

Science.gov (United States)

See, Ya Hui Michelle; Petty, Richard E; Fabrigar, Leandre R

2008-06-01

The authors investigated the predictive utility of people's subjective assessments of whether their evaluations are affect- or cognition driven (i.e., meta-cognitive bases) as separate from whether people's attitudes are actually affect- or cognition based (i.e., structural bases). Study 1 demonstrated that meta-bases uniquely predict interest in affective versus cognitive information above and beyond structural bases and other related variables (i.e., need for cognition and need for affect). In Study 2, meta-bases were shown to account for unique variance in attitude change as a function of appeal type. Finally, Study 3 showed that as people became more deliberative in their judgments, meta-bases increased in predictive utility, and structural bases decreased in predictive utility. These findings support the existence of meta-bases of attitudes and demonstrate that meta-bases are distinguishable from structural bases in their predictive utility. (PsycINFO Database Record (c) 2008 APA, all rights reserved).

On the Multilevel Nature of Meta-Analysis: A Tutorial, Comparison of Software Programs, and Discussion of Analytic Choices.

Science.gov (United States)

Pastor, Dena A; Lazowski, Rory A

2018-01-01

The term "multilevel meta-analysis" is encountered not only in applied research studies, but in multilevel resources comparing traditional meta-analysis to multilevel meta-analysis. In this tutorial, we argue that the term "multilevel meta-analysis" is redundant since all meta-analysis can be formulated as a special kind of multilevel model. To clarify the multilevel nature of meta-analysis the four standard meta-analytic models are presented using multilevel equations and fit to an example data set using four software programs: two specific to meta-analysis (metafor in R and SPSS macros) and two specific to multilevel modeling (PROC MIXED in SAS and HLM). The same parameter estimates are obtained across programs underscoring that all meta-analyses are multilevel in nature. Despite the equivalent results, not all software programs are alike and differences are noted in the output provided and estimators available. This tutorial also recasts distinctions made in the literature between traditional and multilevel meta-analysis as differences between meta-analytic choices, not between meta-analytic models, and provides guidance to inform choices in estimators, significance tests, moderator analyses, and modeling sequence. The extent to which the software programs allow flexibility with respect to these decisions is noted, with metafor emerging as the most favorable program reviewed.

Methemoglobinemia associated with loxoscelism Meta-hemoglobinemia associada ao loxoscelismo

Directory of Open Access Journals (Sweden)

Orlando C. de O. Barreto

1990-02-01

Full Text Available In twenty five patients who presented the cutaneous form of loxoscelism, serum haptoglobin and lactic dehydrogenase, erythrocyte glucose-6-phosphate dehydrogenase, glutathione reductase, glutathione peroxidase, methemoglobin, bilirubin and reticulocytes were investigated after bite. No hemolysis was detected but an increase in methemoglobin was found in 54% of the cases; in 7% it was between 1.1% and 2%, in 27% it ranged from 2.1% to 4%, and in 20% from 4.1% to 8%. Blood samples of a normal, blood group 0 individual and of a patient who exhibited methemoglobinemia after Loxosceles bite were incubated separately with antisera against Loxosceles gaucho, Crotalus terrificus, Bothrops jararaca, with Loxosceles gaucho venom and 0.3% phenol. No methemoglobin was found after 1, 4,8 and 15 days in both sets of samples. At the 25th day all the samples, including the controls, exhibited similar methemoglobin reductase decrease. The data suggest that the methemoglobinemia which occurs in 50% of the patients probably arises from in vivo venom metabolism, inasmuch as the crude venom does not induce methemoglobinemia.Vinte e cinco pacientes que apresentaram a forma cutânea do loxoscelismo foram estudados após a picada, determinando-se a glicose-6-fosfato desidrogenase, glutationa redutase e glutationa peroxidase eritrocitárias, haptoglobina e latico desidrogenase séricas, bilirrubina, reticulócitos e meta-hemoglobina. Não foi observada hemólise aumentada, mas foi detectado aumento da meta-hemoglobina em 54% dos casos: em 7% entre 1,1% e 2%, em 27% variou de 2,1% a 4%, e em 20% de 4,1 a 8%. Amostras de sangue de um indivíduo normal do grupo 0 de uma paciente que exibiu meta-hemoglobina após picada por Loxosceles foram incubadas separadamente com anti-soros contra Loxosceles gancho, Crotalus terrificus e Bothrops jararaca, com veneno de Loxosceles gaucho e fenol a 3%, e não se detectou aumento de meta-hemoglobina depois de 1, 4, 8 e 15 dias em todas

Meta-learning framework applied in bioinformatics inference system design.

Science.gov (United States)

Arredondo, Tomás; Ormazábal, Wladimir

2015-01-01

This paper describes a meta-learner inference system development framework which is applied and tested in the implementation of bioinformatic inference systems. These inference systems are used for the systematic classification of the best candidates for inclusion in bacterial metabolic pathway maps. This meta-learner-based approach utilises a workflow where the user provides feedback with final classification decisions which are stored in conjunction with analysed genetic sequences for periodic inference system training. The inference systems were trained and tested with three different data sets related to the bacterial degradation of aromatic compounds. The analysis of the meta-learner-based framework involved contrasting several different optimisation methods with various different parameters. The obtained inference systems were also contrasted with other standard classification methods with accurate prediction capabilities observed.

LAS METAS MÚLTIPLES: ANÁLISIS PREDICTIVO DEL RENDIMIENTO ACADÉMICO EN ESTUDIANTES CHILENOS

OpenAIRE

Leandro Navas Martínez; José Antonio Soriano Llorca; Francisco Pablo Holgado Tello; Irene Jover Mira

2016-01-01

Este estudio parte de la perspectiva que analiza el contenido de las metas en contextos académicos para explicar la motivación para los estudios. El objeti - vo es analizar la estructura que presentan las metas múltiples en estudiantes chilenos y sus relaciones con el rendimiento académico. Esto implica valorar las cualidades psicométricas del Cuestionario de Metas y valorar la contri - bución de las diferentes metas como variables predictoras del rendimiento académico. Participan 1773 es...

Methods for meta-analysis of multiple traits using GWAS summary statistics.

Science.gov (United States)

Ray, Debashree; Boehnke, Michael

2018-03-01

Genome-wide association studies (GWAS) for complex diseases have focused primarily on single-trait analyses for disease status and disease-related quantitative traits. For example, GWAS on risk factors for coronary artery disease analyze genetic associations of plasma lipids such as total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides (TGs) separately. However, traits are often correlated and a joint analysis may yield increased statistical power for association over multiple univariate analyses. Recently several multivariate methods have been proposed that require individual-level data. Here, we develop metaUSAT (where USAT is unified score-based association test), a novel unified association test of a single genetic variant with multiple traits that uses only summary statistics from existing GWAS. Although the existing methods either perform well when most correlated traits are affected by the genetic variant in the same direction or are powerful when only a few of the correlated traits are associated, metaUSAT is designed to be robust to the association structure of correlated traits. metaUSAT does not require individual-level data and can test genetic associations of categorical and/or continuous traits. One can also use metaUSAT to analyze a single trait over multiple studies, appropriately accounting for overlapping samples, if any. metaUSAT provides an approximate asymptotic P-value for association and is computationally efficient for implementation at a genome-wide level. Simulation experiments show that metaUSAT maintains proper type-I error at low error levels. It has similar and sometimes greater power to detect association across a wide array of scenarios compared to existing methods, which are usually powerful for some specific association scenarios only. When applied to plasma lipids summary data from the METSIM and the T2D-GENES studies, metaUSAT detected genome-wide significant loci beyond the ones identified by univariate analyses

Forecasting urban water demand: A meta-regression analysis.

Science.gov (United States)

Sebri, Maamar

2016-12-01

Water managers and planners require accurate water demand forecasts over the short-, medium- and long-term for many purposes. These range from assessing water supply needs over spatial and temporal patterns to optimizing future investments and planning future allocations across competing sectors. This study surveys the empirical literature on the urban water demand forecasting using the meta-analytical approach. Specifically, using more than 600 estimates, a meta-regression analysis is conducted to identify explanations of cross-studies variation in accuracy of urban water demand forecasting. Our study finds that accuracy depends significantly on study characteristics, including demand periodicity, modeling method, forecasting horizon, model specification and sample size. The meta-regression results remain robust to different estimators employed as well as to a series of sensitivity checks performed. The importance of these findings lies in the conclusions and implications drawn out for regulators and policymakers and for academics alike. Copyright © 2016. Published by Elsevier Ltd.

Meta-analysis in plant pathology: synthesizing research results.

Science.gov (United States)

Rosenberg, M S; Garrett, K A; Su, Z; Bowden, R L

2004-09-01

ABSTRACT Meta-analysis is a set of statistical procedures for synthesizing research results from a number of different studies. An estimate of a statistical effect, such as the difference in disease severity for plants with or without a management treatment, is collected from each study along with a measure of the variance of the estimate of the effect. Combining results from different studies will generally result in increased statistical power so that it is easier to detect small effects. Combining results from different studies may also make it possible to compare the size of the effect as a function of other predictor variables such as geographic region or pathogen species. We present a review of the basic methodology for meta-analysis. We also present an example of meta-analysis of the relationship between disease severity and yield loss for foliar wheat diseases, based on data collected from a decade of fungicide and nematicide test results.

Meta-Analyses of Predictors of Hope in Adolescents.

Science.gov (United States)

Yarcheski, Adela; Mahon, Noreen E

2016-03-01

The purposes of this study were to identify predictors of hope in the literature reviewed, to use meta-analysis to determine the mean effect size (ES) across studies between each predictor and hope, and to examine four moderators on each predictor-hope relationship. Using preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines for the literature reviewed, 77 published studies or doctoral dissertations completed between 1990 and 2012 met the inclusion criteria. Eleven predictors of hope were identified and each predictor in relation to hope was subjected to meta-analysis. Five predictors (positive affect, life satisfaction, optimism, self-esteem, and social support) of hope had large mean ESs, 1 predictor (depression) had a medium ES, 4 predictors (negative affect, stress, academic achievement, and violence) had small ESs, and 1 predictor (gender) had a trivial ES. Findings are interpreted for the 11 predictors in relation to hope. Limitations and conclusions are addressed; future studies are recommended. © The Author(s) 2014.

Meta Modernism: An Introduction

Science.gov (United States)

Snell, Joel

2016-01-01

The author introduces Hegel. From the triad (Hegelian Dialect), he briefly gives an overview of the history of philosophy. In true Hegelian form, it is now time to reform "Postmodernism" and replace it with "Meta modernism." Postmodern had a short life from 1950 to now and has left few adherents. It is confusing and…

Interleukin-8 for diagnosis of neonatal sepsis: a meta-analysis.

Directory of Open Access Journals (Sweden)

Min Zhou

Full Text Available Neonatal sepsis (NS is a life-threatening disorder and an important cause of morbidity and mortality in neonates. Previous studies showed that interleukin 8 (IL-8 may effectively and rapidly diagnose NS.We conducted the systematic review and meta-analysis to investigate the diagnostic value of the IL-8 in NS.The literature was searched in PUBMED, EMBASE, Cochrane Library, CNKI, VIP and other Chinese Medical Databases during October 1998 to January 2014 using set search criteria. Each included study was evaluated by quality assessment of diagnostic accuracy studies tool. Two investigators independently extracted the data and study characteristics, and disagreements, if any, were resolved by consensus. Meta-disc software was used to calculate the pooled sensitivity, specificity and summary diagnostic odds ratio (SDOR, I² or Cochrane Q to test heterogeneity, and meta-regression to investigate the source of heterogeneity. Funnel plots were used to test the potential presence of publication bias. False-positive report probability (FPRP was calculated to confirm the significance of the results.Eight studies (548 neonates were included in this meta-analysis. The pooled sensitivity and specificity of IL-8 were 0.78 and 0.84, respectively, which had moderate accuracy in the diagnosis of NS. The pooled diagnostic odds ratio (DOR and area under curve (AUC was 21.64 and 0.8908 (Q*=0.8215, respectively. The diagnostic threshold analysis showed that there was no threshold effect. The meta-regression analysis showed the cut-off, QUADAS and onset time have no effect on the heterogeneity. The funnel plots showed the existence of publication bias.Meta-analysis showed IL-8 had a moderate accuracy (AUC=0.8908 for the diagnosis of NS. IL-8 is a helpful biomarker for early diagnosis of NS. However, we should combine the results with clinical symptoms and signs, laboratory and microbial results.

Age, the psychological contract, and job attitudes : a meta-analysis

NARCIS (Netherlands)

Bal, P. Matthijs; de Lange, Annet H.; Jansen, Paul G. W.; van der Velde, Mandy E. G.

Age, the psychological contract, and job attitudes: a meta-analysis P.M. Bal, A H. De Lange, P.G.W Jansen Er M.E G Van der Velde, Gedrag en Organisatie, volume 23, March 2010, nr 1, pp 44-72. The meta-analysis investigated the relations between age and psychological contracts It was expected that

Effect of reporting bias on meta-analyses of drug trials

DEFF Research Database (Denmark)

Hart, Beth; Lundh, Andreas; Bero, Lisa

2012-01-01

To investigate the effect of including unpublished trial outcome data obtained from the Food and Drug Administration (FDA) on the results of meta-analyses of drug trials.......To investigate the effect of including unpublished trial outcome data obtained from the Food and Drug Administration (FDA) on the results of meta-analyses of drug trials....

Using beta coefficients to impute missing correlations in meta-analysis research: Reasons for caution.

Science.gov (United States)

Roth, Philip L; Le, Huy; Oh, In-Sue; Van Iddekinge, Chad H; Bobko, Philip

2018-06-01

Meta-analysis has become a well-accepted method for synthesizing empirical research about a given phenomenon. Many meta-analyses focus on synthesizing correlations across primary studies, but some primary studies do not report correlations. Peterson and Brown (2005) suggested that researchers could use standardized regression weights (i.e., beta coefficients) to impute missing correlations. Indeed, their beta estimation procedures (BEPs) have been used in meta-analyses in a wide variety of fields. In this study, the authors evaluated the accuracy of BEPs in meta-analysis. We first examined how use of BEPs might affect results from a published meta-analysis. We then developed a series of Monte Carlo simulations that systematically compared the use of existing correlations (that were not missing) to data sets that incorporated BEPs (that impute missing correlations from corresponding beta coefficients). These simulations estimated ρ̄ (mean population correlation) and SDρ (true standard deviation) across a variety of meta-analytic conditions. Results from both the existing meta-analysis and the Monte Carlo simulations revealed that BEPs were associated with potentially large biases when estimating ρ̄ and even larger biases when estimating SDρ. Using only existing correlations often substantially outperformed use of BEPs and virtually never performed worse than BEPs. Overall, the authors urge a return to the standard practice of using only existing correlations in meta-analysis. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Instance Selection for Classifier Performance Estimation in Meta Learning

OpenAIRE

Marcin Blachnik

2017-01-01

Building an accurate prediction model is challenging and requires appropriate model selection. This process is very time consuming but can be accelerated with meta-learning–automatic model recommendation by estimating the performances of given prediction models without training them. Meta-learning utilizes metadata extracted from the dataset to effectively estimate the accuracy of the model in question. To achieve that goal, metadata descriptors must be gathered efficiently and must be inform...

Metaprop: a Stata command to perform meta-analysis of binomial data.

Science.gov (United States)

Nyaga, Victoria N; Arbyn, Marc; Aerts, Marc

2014-01-01

Meta-analyses have become an essential tool in synthesizing evidence on clinical and epidemiological questions derived from a multitude of similar studies assessing the particular issue. Appropriate and accessible statistical software is needed to produce the summary statistic of interest. Metaprop is a statistical program implemented to perform meta-analyses of proportions in Stata. It builds further on the existing Stata procedure metan which is typically used to pool effects (risk ratios, odds ratios, differences of risks or means) but which is also used to pool proportions. Metaprop implements procedures which are specific to binomial data and allows computation of exact binomial and score test-based confidence intervals. It provides appropriate methods for dealing with proportions close to or at the margins where the normal approximation procedures often break down, by use of the binomial distribution to model the within-study variability or by allowing Freeman-Tukey double arcsine transformation to stabilize the variances. Metaprop was applied on two published meta-analyses: 1) prevalence of HPV-infection in women with a Pap smear showing ASC-US; 2) cure rate after treatment for cervical precancer using cold coagulation. The first meta-analysis showed a pooled HPV-prevalence of 43% (95% CI: 38%-48%). In the second meta-analysis, the pooled percentage of cured women was 94% (95% CI: 86%-97%). By using metaprop, no studies with 0% or 100% proportions were excluded from the meta-analysis. Furthermore, study specific and pooled confidence intervals always were within admissible values, contrary to the original publication, where metan was used.

Natural funnel asymmetries. A simulation analysis of the three basic tools of meta analysis

DEFF Research Database (Denmark)

Callot, Laurent Abdelkader Francois; Paldam, Martin

Meta-analysis studies a set of estimates of one parameter with three basic tools: The funnel diagram is the distribution of the estimates as a function of their precision; the funnel asymmetry test, FAT; and the meta average, where PET is an estimate. The FAT-PET MRA is a meta regression analysis...

GetReal in network meta-analysis : a review of the methodology

NARCIS (Netherlands)

Efthimiou, Orestis; Debray, Thomas P A; van Valkenhoef, Gert; Trelle, Sven; Panayidou, Klea; Moons, Karel G M; Reitsma, Johannes B.; Shang, Aijing; Salanti, Georgia

2016-01-01

Pairwise meta-analysis is an established statistical tool for synthesizing evidence from multiple trials, but it is informative only about the relative efficacy of two specific interventions. The usefulness of pairwise meta-analysis is thus limited in real-life medical practice, where many competing

Network meta-analysis-highly attractive but more methodological research is needed

NARCIS (Netherlands)

Li, Tianjing; Puhan, Milo A.; Vedula, Swaroop S.; Singh, Sonal; Dickersin, Kay; Cameron, Chris; Goodman, Steven N.; Mills, Edward; Musch, David; ter Riet, Gerben; Robinson, Karen; Schmid, Christopher; Song, Fujian; Thorlund, Kristian; Trikalinos, Thomas

2011-01-01

Network meta-analysis, in the context of a systematic review, is a meta-analysis in which multiple treatments (that is, three or more) are being compared using both direct comparisons of interventions within randomized controlled trials and indirect comparisons across trials based on a common

Matching Procedures in Autism Research: Evidence from Meta-Analytic Studies

Science.gov (United States)

Shaked, Michal; Yirmiya, Nurit

2004-01-01

In this paper, we summarize some of our findings from a series of three meta-analyses and discuss their implications for autism research. In the first meta-analysis, we examined studies addressing the theory of mind hypothesis in autism. This analysis revealed that theory of mind disabilities are not unique to autism, although what may be unique…

Estimation of silver in Ag-meta kaolinite by neutron activation

International Nuclear Information System (INIS)

Daniels, E.A.; Rao, S.M.

1981-01-01

The present work is based on the neutron activation of Ag-meta kaolinite for the determination of its silver content from the β-activity of the compound using standard tables which showed the percentage of silver in mixtures of silver nitrate and meta kaolinite of known composition against β-activity of the mixture activated under identical conditions. (author)

Bayesian meta-analysis models for microarray data: a comparative study

Directory of Open Access Journals (Sweden)

Song Joon J

2007-03-01

Full Text Available Abstract Background With the growing abundance of microarray data, statistical methods are increasingly needed to integrate results across studies. Two common approaches for meta-analysis of microarrays include either combining gene expression measures across studies or combining summaries such as p-values, probabilities or ranks. Here, we compare two Bayesian meta-analysis models that are analogous to these methods. Results Two Bayesian meta-analysis models for microarray data have recently been introduced. The first model combines standardized gene expression measures across studies into an overall mean, accounting for inter-study variability, while the second combines probabilities of differential expression without combining expression values. Both models produce the gene-specific posterior probability of differential expression, which is the basis for inference. Since the standardized expression integration model includes inter-study variability, it may improve accuracy of results versus the probability integration model. However, due to the small number of studies typical in microarray meta-analyses, the variability between studies is challenging to estimate. The probability integration model eliminates the need to model variability between studies, and thus its implementation is more straightforward. We found in simulations of two and five studies that combining probabilities outperformed combining standardized gene expression measures for three comparison values: the percent of true discovered genes in meta-analysis versus individual studies; the percent of true genes omitted in meta-analysis versus separate studies, and the number of true discovered genes for fixed levels of Bayesian false discovery. We identified similar results when pooling two independent studies of Bacillus subtilis. We assumed that each study was produced from the same microarray platform with only two conditions: a treatment and control, and that the data sets

Managing complex research datasets using electronic tools: A meta-analysis exemplar

Science.gov (United States)

Brown, Sharon A.; Martin, Ellen E.; Garcia, Theresa J.; Winter, Mary A.; García, Alexandra A.; Brown, Adama; Cuevas, Heather E.; Sumlin, Lisa L.

2013-01-01

Meta-analyses of broad scope and complexity require investigators to organize many study documents and manage communication among several research staff. Commercially available electronic tools, e.g., EndNote, Adobe Acrobat Pro, Blackboard, Excel, and IBM SPSS Statistics (SPSS), are useful for organizing and tracking the meta-analytic process, as well as enhancing communication among research team members. The purpose of this paper is to describe the electronic processes we designed, using commercially available software, for an extensive quantitative model-testing meta-analysis we are conducting. Specific electronic tools improved the efficiency of (a) locating and screening studies, (b) screening and organizing studies and other project documents, (c) extracting data from primary studies, (d) checking data accuracy and analyses, and (e) communication among team members. The major limitation in designing and implementing a fully electronic system for meta-analysis was the requisite upfront time to: decide on which electronic tools to use, determine how these tools would be employed, develop clear guidelines for their use, and train members of the research team. The electronic process described here has been useful in streamlining the process of conducting this complex meta-analysis and enhancing communication and sharing documents among research team members. PMID:23681256

Meta-analysis for genome-wide association studies using case-control design: application and practice.

Science.gov (United States)

Shim, Sungryul; Kim, Jiyoung; Jung, Wonguen; Shin, In-Soo; Bae, Jong-Myon

2016-01-01

This review aimed to arrange the process of a systematic review of genome-wide association studies in order to practice and apply a genome-wide meta-analysis (GWMA). The process has a series of five steps: searching and selection, extraction of related information, evaluation of validity, meta-analysis by type of genetic model, and evaluation of heterogeneity. In contrast to intervention meta-analyses, GWMA has to evaluate the Hardy-Weinberg equilibrium (HWE) in the third step and conduct meta-analyses by five potential genetic models, including dominant, recessive, homozygote contrast, heterozygote contrast, and allelic contrast in the fourth step. The 'genhwcci' and 'metan' commands of STATA software evaluate the HWE and calculate a summary effect size, respectively. A meta-regression using the 'metareg' command of STATA should be conducted to evaluate related factors of heterogeneities.

A hierarchy of patient-reported outcome measures for meta-analysis of knee osteoarthritis trials

DEFF Research Database (Denmark)

Juhl, Carsten Bogh; Lund, Hans; Guyatt, GH

2010-01-01

Title A hierarchy of patient-reported outcome measures for meta-analysis of knee osteoarthritis trials: empirical evidence from a survey of high impact journals Objective To develop a prioritized list for extracting patient-reported outcomes (PROs) measuring pain and disability for meta-analyses ......Title A hierarchy of patient-reported outcome measures for meta-analysis of knee osteoarthritis trials: empirical evidence from a survey of high impact journals Objective To develop a prioritized list for extracting patient-reported outcomes (PROs) measuring pain and disability for meta...... composite disability scores. Conclusions As choosing the most favorable PROs from individual trials can overestimate the effect compared to a systematic approach, using a prioritized list as presented in this study is recommended to reduce reviewer's likelihood of biased selection of PROs in meta-analyses....

MetaFIND: A feature analysis tool for metabolomics data

Directory of Open Access Journals (Sweden)

Cunningham Pádraig

2008-11-01

Full Text Available Abstract Background Metabolomics, or metabonomics, refers to the quantitative analysis of all metabolites present within a biological sample and is generally carried out using NMR spectroscopy or Mass Spectrometry. Such analysis produces a set of peaks, or features, indicative of the metabolic composition of the sample and may be used as a basis for sample classification. Feature selection may be employed to improve classification accuracy or aid model explanation by establishing a subset of class discriminating features. Factors such as experimental noise, choice of technique and threshold selection may adversely affect the set of selected features retrieved. Furthermore, the high dimensionality and multi-collinearity inherent within metabolomics data may exacerbate discrepancies between the set of features retrieved and those required to provide a complete explanation of metabolite signatures. Given these issues, the latter in particular, we present the MetaFIND application for 'post-feature selection' correlation analysis of metabolomics data. Results In our evaluation we show how MetaFIND may be used to elucidate metabolite signatures from the set of features selected by diverse techniques over two metabolomics datasets. Importantly, we also show how MetaFIND may augment standard feature selection and aid the discovery of additional significant features, including those which represent novel class discriminating metabolites. MetaFIND also supports the discovery of higher level metabolite correlations. Conclusion Standard feature selection techniques may fail to capture the full set of relevant features in the case of high dimensional, multi-collinear metabolomics data. We show that the MetaFIND 'post-feature selection' analysis tool may aid metabolite signature elucidation, feature discovery and inference of metabolic correlations.

Fatal flaws in a recent meta-analysis on abortion and mental health.

Science.gov (United States)

Steinberg, Julia R; Trussell, James; Hall, Kelli S; Guthrie, Kate

2012-11-01

Similar to other reviews within the last 4 years, a thorough review by the Royal College of Psychiatrists, published in December 2011, found that compared to delivery of an unintended pregnancy, abortion does not increase women's risk of mental health problems. In contrast, a meta-analysis published in September 2011 concluded that abortion increases women's risk of mental health problems by 81% and that 10% of mental health problems are attributable to abortions. Like others, we strongly question the quality of this meta-analysis and its conclusions. Here we detail seven errors of this meta-analysis and three significant shortcomings of the included studies because policy, practice and the public have been misinformed. These errors and shortcomings render the meta-analysis' conclusions invalid. Copyright © 2012 Elsevier Inc. All rights reserved.

Subsystem density functional theory with meta-generalized gradient approximation exchange-correlation functionals.

Science.gov (United States)

Śmiga, Szymon; Fabiano, Eduardo; Laricchia, Savio; Constantin, Lucian A; Della Sala, Fabio

2015-04-21

We analyze the methodology and the performance of subsystem density functional theory (DFT) with meta-generalized gradient approximation (meta-GGA) exchange-correlation functionals for non-bonded molecular systems. Meta-GGA functionals depend on the Kohn-Sham kinetic energy density (KED), which is not known as an explicit functional of the density. Therefore, they cannot be directly applied in subsystem DFT calculations. We propose a Laplacian-level approximation to the KED which overcomes this limitation and provides a simple and accurate way to apply meta-GGA exchange-correlation functionals in subsystem DFT calculations. The so obtained density and energy errors, with respect to the corresponding supermolecular calculations, are comparable with conventional approaches, depending almost exclusively on the approximations in the non-additive kinetic embedding term. An embedding energy error decomposition explains the accuracy of our method.

Autogenic training: a meta-analysis of clinical outcome studies.

Science.gov (United States)

Stetter, Friedhelm; Kupper, Sirko

2002-03-01

Autogenic training (AT) is a self-relaxation procedure by which a psychophysiological determined relaxation response is elicited. A meta-analysis was performed to evaluate the clinical effectiveness of AT. Seventy-three controlled outcome studies were found (published 1952-99). Sixty studies (35 randomized controlled trials [RCT]) qualified for inclusion in the meta-analysis. Medium-to-large effect sizes (ES) occurred for pre-post comparisons of disease-specific AT-effects, with the RCTs showing larger ES. When AT was compared to real control conditions, medium ES were found. Comparisons of AT versus other psychological treatment mostly resulted in no effects or small negative ES. This pattern of results was stable at follow-up. Unspecific AT-effects (i.e., effects on mood, cognitive performance, quality of life, and physiological variables) tended to be even larger than main effects. Separate meta-analyses for different disorders revealed a significant reduction of the heterogeneity of ES. Positive effects (medium range) of AT and of AT versus control in the meta-analysis of at least 3 studies were found for tension headache/migraine, mild-to-moderate essential hypertension, coronary heart disease, asthma bronchiale, somatoform pain disorder (unspecified type), Raynaud's disease, anxiety disorders, mild-to-moderate depression/dysthymia, and functional sleep disorders.

Meta-analyses of HFE variants in coronary heart disease.

Science.gov (United States)

Lian, Jiangfang; Xu, Limin; Huang, Yi; Le, Yanping; Jiang, Danjie; Yang, Xi; Xu, Weifeng; Huang, Xiaoyan; Dong, Changzheng; Ye, Meng; Zhou, Jianqing; Duan, Shiwei

2013-09-15

HFE gene variants can cause hereditary hemochromatosis (HH) that often comes along with an increased risk of coronary heart disease (CHD). The goal of our study is to assess the contribution of four HFE gene variants to the risk of CHD. We conducted four meta-analyses of the studies examining the association between four HFE gene variants and the risk of CHD. A systematic search was conducted using MEDLINE, EMBASE, Web of Science and China National Knowledge Infrastructure (CNKI), Wanfang Chinese Periodical. Meta-analyses showed that HFE rs1799945-G allele was associated with a 6% increased risk of CHD (P=0.02, odds ratio (OR)=1.06, 95% confidence interval (CI)=1.01-1.11). However, no association between the other three HFE gene variants (rs1800562, rs1800730, and rs9366637) and CHD risk was observed by the meta-analyses (all P values>0.05). In addition, the results of our case-control study indicated that rs1800562 and rs1800730 were monomorphic, and that rs1799945 and rs9366637 were not associated with CHD in Han Chinese. Our meta-analysis suggested that a significant association existed between rs1799945 mutation and CHD, although this mutation was rare in Han Chinese. Copyright © 2013 Elsevier B.V. All rights reserved.

Night shift work and breast cancer risk: what do the meta-analyses tell us?

Science.gov (United States)

Pahwa, Manisha; Labrèche, France; Demers, Paul A

2018-05-22

Objectives This paper aims to compare results, assess the quality, and discuss the implications of recently published meta-analyses of night shift work and breast cancer risk. Methods A comprehensive search was conducted for meta-analyses published from 2007-2017 that included at least one pooled effect size (ES) for breast cancer associated with any night shift work exposure metric and were accompanied by a systematic literature review. Pooled ES from each meta-analysis were ascertained with a focus on ever/never exposure associations. Assessments of heterogeneity and publication bias were also extracted. The AMSTAR 2 checklist was used to evaluate quality. Results Seven meta-analyses, published from 2013-2016, collectively included 30 cohort and case-control studies spanning 1996-2016. Five meta-analyses reported pooled ES for ever/never night shift work exposure; these ranged from 0.99 [95% confidence interval (CI) 0.95-1.03, N=10 cohort studies) to 1.40 (95% CI 1.13-1.73, N=9 high quality studies). Estimates for duration, frequency, and cumulative night shift work exposure were scant and mostly not statistically significant. Meta-analyses of cohort, Asian, and more fully-adjusted studies generally resulted in lower pooled ES than case-control, European, American, or minimally-adjusted studies. Most reported statistically significant between-study heterogeneity. Publication bias was not evident in any of the meta-analyses. Only one meta-analysis was strong in critical quality domains. Conclusions Fairly consistent elevated pooled ES were found for ever/never night shift work and breast cancer risk, but results for other shift work exposure metrics were inconclusive. Future evaluations of shift work should incorporate high quality meta-analyses that better appraise individual study quality.

Association between Hypertension and Epistaxis: Systematic Review and Meta-analysis.

Science.gov (United States)

Min, Hyun Jin; Kang, Hyun; Choi, Geun Joo; Kim, Kyung Soo

2017-12-01

Objective Whether there is an association or a cause-and-effect relationship between epistaxis and hypertension is a subject of longstanding controversy. The objective of this systematic review and meta-analysis was to determine the association between epistaxis and hypertension and to verify whether hypertension is an independent risk factor of epistaxis. Data Sources A comprehensive search was performed using the MEDLINE, EMBASE, and Cochrane Library databases. Review Methods The review was performed according to the Meta-analysis of Observational Studies in Epidemiology guidelines and reported using the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. Results We screened 2768 unique studies and selected 10 for this meta-analysis. Overall, the risk of epistaxis was significantly increased for patients with hypertension (odds ratio, 1.532 [95% confidence interval (CI), 1.181-1.986]; number needed to treat, 14.9 [95% CI, 12.3-19.0]). Results of the Q test and I 2 statistics suggested considerable heterogeneity ([Formula: see text] = 0.038, I 2 = 49.3%). The sensitivity analysis was performed by excluding 1 study at a time, and it revealed no change in statistical significance. Conclusion Although this meta-analysis had some limitations, our study demonstrated that hypertension was significantly associated with the risk of epistaxis. However, since this association does not support a causal relationship between hypertension and epistaxis, further clinical trials with large patient populations will be required to determine the impact of hypertension on epistaxis.

Limitations and risks of meta-analyses of longevity studies

DEFF Research Database (Denmark)

Sebastiani, Paola; Bae, Harold; Gurinovich, Anastasia

2017-01-01

Searching for genetic determinants of human longevity has been challenged by the rarity of data sets with large numbers of individuals who have reached extreme old age, inconsistent definitions of the phenotype, and the difficulty of defining appropriate controls. Meta-analysis - a statistical...... method to summarize results from different studies - has become a common tool in genetic epidemiology to accrue large sample sizes for powerful genetic association studies. In conducting a meta-analysis of studies of human longevity however, particular attention must be made to the definition of cases...... and controls (including their health status) and on the effect of possible confounders such as sex and ethnicity upon the genetic effect to be estimated. We will show examples of how a meta-analysis can inflate the false negative rates of genetic association studies or it can bias estimates of the association...

Derivative discontinuity and exchange-correlation potential of meta-GGAs in density-functional theory.

Science.gov (United States)

Eich, F G; Hellgren, Maria

2014-12-14

We investigate fundamental properties of meta-generalized-gradient approximations (meta-GGAs) to the exchange-correlation energy functional, which have an implicit density dependence via the Kohn-Sham kinetic-energy density. To this purpose, we construct the most simple meta-GGA by expressing the local exchange-correlation energy per particle as a function of a fictitious density, which is obtained by inverting the Thomas-Fermi kinetic-energy functional. This simple functional considerably improves the total energy of atoms as compared to the standard local density approximation. The corresponding exchange-correlation potentials are then determined exactly through a solution of the optimized effective potential equation. These potentials support an additional bound state and exhibit a derivative discontinuity at integer particle numbers. We further demonstrate that through the kinetic-energy density any meta-GGA incorporates a derivative discontinuity. However, we also find that for commonly used meta-GGAs the discontinuity is largely underestimated and in some cases even negative.

Estimating required information size by quantifying diversity in random-effects model meta-analyses

DEFF Research Database (Denmark)

Wetterslev, Jørn; Thorlund, Kristian; Brok, Jesper

2009-01-01

an intervention effect suggested by trials with low-risk of bias. METHODS: Information size calculations need to consider the total model variance in a meta-analysis to control type I and type II errors. Here, we derive an adjusting factor for the required information size under any random-effects model meta......-analysis. RESULTS: We devise a measure of diversity (D2) in a meta-analysis, which is the relative variance reduction when the meta-analysis model is changed from a random-effects into a fixed-effect model. D2 is the percentage that the between-trial variability constitutes of the sum of the between...... and interpreted using several simulations and clinical examples. In addition we show mathematically that diversity is equal to or greater than inconsistency, that is D2 >or= I2, for all meta-analyses. CONCLUSION: We conclude that D2 seems a better alternative than I2 to consider model variation in any random...

Derivative discontinuity and exchange-correlation potential of meta-GGAs in density-functional theory

International Nuclear Information System (INIS)

Eich, F. G.; Hellgren, Maria

2014-01-01

We investigate fundamental properties of meta-generalized-gradient approximations (meta-GGAs) to the exchange-correlation energy functional, which have an implicit density dependence via the Kohn-Sham kinetic-energy density. To this purpose, we construct the most simple meta-GGA by expressing the local exchange-correlation energy per particle as a function of a fictitious density, which is obtained by inverting the Thomas-Fermi kinetic-energy functional. This simple functional considerably improves the total energy of atoms as compared to the standard local density approximation. The corresponding exchange-correlation potentials are then determined exactly through a solution of the optimized effective potential equation. These potentials support an additional bound state and exhibit a derivative discontinuity at integer particle numbers. We further demonstrate that through the kinetic-energy density any meta-GGA incorporates a derivative discontinuity. However, we also find that for commonly used meta-GGAs the discontinuity is largely underestimated and in some cases even negative

Exercise and Bone Density: Meta-Analysis

National Research Council Canada - National Science Library

Kelley, George A; Sharpe-Kelley, Kristi

2007-01-01

.... Since no meta-analysis had existed using individual patient data (IPD) to examine the effects of exercise on BMD, our second two-year period of funding was devoted to examining the feasibility...

Validation of the Adolescent Meta-cognition Questionnaire Version

Directory of Open Access Journals (Sweden)

Kazem Khoramdel

2012-03-01

Full Text Available Background: The role and importance of meta-cognitive beliefs in creating and retaining of anxiety disorders were explained initially in meta-cognitive theory. The purpose of this study was to validate the Meta-cognitions Questionnaire-Adolescent version (MCQ-A in normal Iranian people and compare of meta-cognitive beliefs between adolescents with anxiety disorders and normal individuals.Materials and Method: This was a standardized study. First of all, the original version was translated into Persian then administered to 204 (101 boys and 103 girls adolescent aged 13 through 17 years. Theyhave been clustered randomly. They were selected from the schools of Isfahan, together with mood and feelings questionnaire and revised children's manifest anxiety scale. In order to assess reliability, method of internal consistency (Chronbach’s alpha and split-half coefficient was used, and also in order to assess validity, convergent validity, criterion validity and confirmatory factor analysis were used. Results: The results of correlation coefficient of convergent validity showed a relation between total score of (MCQ-A and its components with anxiety and depression except cognitive self-consciousness. Data were indicative of appropriate level of Coranbach’s alpha and split-half reliability coefficients of the MCQ-A and extracted factors. The results of factor analysis by principle components analysis and using varimax rotation showed 5 factors that account for 0.45% of the variance. Conclusion: MCQ-A has satisfactory psychometric properties in Iranian people

Anxiety Levels in Children with Autism Spectrum Disorder : A Meta-Analysis

NARCIS (Netherlands)

van Steensel, F.J.A.; Heeman, E.J.

The aim of the current study was to meta-analytically examine whether anxiety levels in children with autism spectrum disorders (ASD) are elevated. A total of 83 articles were selected from a systematic literature search and were included in the meta-analyses. Results demonstrated that children with

A meta-analysis of serious digital games for healthy lifestyle promotion

Science.gov (United States)

Several systematic reviews have described health-promoting effects of serious games, but so far no meta-analysis has been reported. This paper presents a meta-analysis of 54 serious digital game studies for healthy lifestyle promotion, in which we investigated the overall effectiveness of serious di...

Meta-analyses on viral hepatitis

DEFF Research Database (Denmark)

Gluud, Lise L; Gluud, Christian

2009-01-01

This article summarizes the meta-analyses of interventions for viral hepatitis A, B, and C. Some of the interventions assessed are described in small trials with unclear bias control. Other interventions are supported by large, high-quality trials. Although attempts have been made to adjust...

Systematic review and meta-analyses

DEFF Research Database (Denmark)

Dreier, Julie Werenberg; Andersen, Anne-Marie Nybo; Berg-Beckhoff, Gabriele

2014-01-01

1990 were excluded. RESULTS: The available literature supported an increased risk of adverse offspring health in association with fever during pregnancy. The strongest evidence was available for neural tube defects, congenital heart defects, and oral clefts, in which meta-analyses suggested between a 1...

Improved score statistics for meta-analysis in single-variant and gene-level association studies.

Science.gov (United States)

Yang, Jingjing; Chen, Sai; Abecasis, Gonçalo

2018-06-01

Meta-analysis is now an essential tool for genetic association studies, allowing them to combine large studies and greatly accelerating the pace of genetic discovery. Although the standard meta-analysis methods perform equivalently as the more cumbersome joint analysis under ideal settings, they result in substantial power loss under unbalanced settings with various case-control ratios. Here, we investigate the power loss problem by the standard meta-analysis methods for unbalanced studies, and further propose novel meta-analysis methods performing equivalently to the joint analysis under both balanced and unbalanced settings. We derive improved meta-score-statistics that can accurately approximate the joint-score-statistics with combined individual-level data, for both linear and logistic regression models, with and without covariates. In addition, we propose a novel approach to adjust for population stratification by correcting for known population structures through minor allele frequencies. In the simulated gene-level association studies under unbalanced settings, our method recovered up to 85% power loss caused by the standard methods. We further showed the power gain of our methods in gene-level tests with 26 unbalanced studies of age-related macular degeneration . In addition, we took the meta-analysis of three unbalanced studies of type 2 diabetes as an example to discuss the challenges of meta-analyzing multi-ethnic samples. In summary, our improved meta-score-statistics with corrections for population stratification can be used to construct both single-variant and gene-level association studies, providing a useful framework for ensuring well-powered, convenient, cross-study analyses. © 2018 WILEY PERIODICALS, INC.

Thresholds for statistical and clinical significance in systematic reviews with meta-analytic methods

DEFF Research Database (Denmark)

Jakobsen, Janus Christian; Wetterslev, Jorn; Winkel, Per

2014-01-01

BACKGROUND: Thresholds for statistical significance when assessing meta-analysis results are being insufficiently demonstrated by traditional 95% confidence intervals and P-values. Assessment of intervention effects in systematic reviews with meta-analysis deserves greater rigour. METHODS......: Methodologies for assessing statistical and clinical significance of intervention effects in systematic reviews were considered. Balancing simplicity and comprehensiveness, an operational procedure was developed, based mainly on The Cochrane Collaboration methodology and the Grading of Recommendations...... Assessment, Development, and Evaluation (GRADE) guidelines. RESULTS: We propose an eight-step procedure for better validation of meta-analytic results in systematic reviews (1) Obtain the 95% confidence intervals and the P-values from both fixed-effect and random-effects meta-analyses and report the most...

A systematic review and meta-analysis of the circulatory, erythrocellular and CSF selenium levels in Alzheimer's disease: A metal meta-analysis (AMMA study-I).

Science.gov (United States)

Reddy, Varikasuvu Seshadri; Bukke, Suman; Dutt, Naveen; Rana, Puneet; Pandey, Arun Kumar

2017-07-01

Available studies in the literature on the selenium levels in Alzheimer's disease (AD) are inconsistent with some studies reporting its decrease in the circulation, while others reported an increase or no change as compared to controls. The objective of this study was to perform a meta-analysis of circulatory (plasma/serum and blood), erythrocyte and cerebrospinal fluid (CSF) selenium levels in AD compared controls. We also performed a meta-analysis of the correlation coefficients (r) to demonstrate the associations between selenium and glutathione peroxidase (GPx) in AD patients. All major databases were searched for eligible studies. We included 12 case-control/observational studies reporting selenium concentrations in AD and controls. Pooled-overall effect size as standardized mean difference (SMD) and pooled r-values were generated using Review Manager 5.3 and MedCalc 15.8 software. Random-effects meta-analysis indicated a decrease in circulatory (SMD=-0.44), erythrocellular (SMD=-0.52) and CSF (SMD=-0.14) selenium levels in AD patients compared to controls. Stratified meta-analysis demonstrated that the selenium levels were decreased in both the subgroups with (SMD=-0.55) and without (SMD=-0.37) age matching between AD and controls. Our results also demonstrated a direct association between decreased selenium levels and GPx in AD. This meta-analysis suggests that circulatory selenium concentration is significantly lower in AD patients compared to controls and this decrease in selenium is directly correlated with an important antioxidant enzyme, the GPx, in AD. Copyright © 2017 Elsevier GmbH. All rights reserved.

Solving Large Clustering Problems with Meta-Heuristic Search

DEFF Research Database (Denmark)

Turkensteen, Marcel; Andersen, Kim Allan; Bang-Jensen, Jørgen

In Clustering Problems, groups of similar subjects are to be retrieved from data sets. In this paper, Clustering Problems with the frequently used Minimum Sum-of-Squares Criterion are solved using meta-heuristic search. Tabu search has proved to be a successful methodology for solving optimization...... problems, but applications to large clustering problems are rare. The simulated annealing heuristic has mainly been applied to relatively small instances. In this paper, we implement tabu search and simulated annealing approaches and compare them to the commonly used k-means approach. We find that the meta-heuristic...

Softwareland Chronicles: A Software Development Meta-Process Proposal

Directory of Open Access Journals (Sweden)

Bolanos Sandro

2016-05-01

Full Text Available This paper presents the software development meta-process (SD-MP as a proposal to set up software projects. Within this proposal we offer conceptual elements that help solve the war of methodologies and processes in favor of an integrating viewpoint, where the main flaws associated with conventional and agile approaches are removed. Our newly developed software platform to support the meta-process is also presented together with three case studies involving projects currently in progress, where the framework proposed in SD-MP has been applied.

A meta-analysis of cerebrovascular disease and hyperhomocysteinaemia

DEFF Research Database (Denmark)

Nielsen, G M; Tvedegaard, K C; Andersen, Niels Trolle

2000-01-01

Hyperhomocysteinaemia has been identified as a risk factor for stroke and cerebrovascular disease in several studies. To evaluate the evidence we performed a meta-analysis. We found 21 studies searching Medline from 1966-July 1999 using the key words homocysteine, homocystine and cerebrovascular...... was used. The reports on 8 cross-sectional and 4 longitudinal studies gave data on the mean and standard deviations of plasma or serum homocysteine for both cases and controls, and these studies were included in the meta-analysis. The results of the 5 excluded studies all pointed to a positive relationship...

The prevalence of food allergy: A meta-analysis

DEFF Research Database (Denmark)

Rona, Roberto J.; Keil, Thomas; Summers, Colin

2007-01-01

Background: There is uncertainty about the prevalence of food allergy in communities. Objective: To assess the prevalence of food allergy by performing a meta-analysis according to the method of assessment used. Methods: The foods assessed were cow's milk, hen's egg, peanut, fish, shellfish....... The meta-analysis included only original studies. They were stratified by age groups: infant/preschool, school children, and adults. Results: A total of 934 articles were identified, but only 51 were considered appropriate for inclusion. The prevalence of self-reported food allergy was very high compared...

Understanding the physical attractiveness literature: Qualitative reviews versus meta-analysis.

Science.gov (United States)

Feingold, Alan

2017-01-01

The target article is a qualitative review of selected findings in the physical attractiveness literature. This commentary explains why the meta-analytic approach, frequently used by other attractiveness reviewers, is preferable for drawing unbiased conclusions about the effects of attractiveness. The article's main contribution is affording a foundation for subsequent meta-analysis of the studies discussed in a subjective fashion.