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Sample records for merocyanine mc form

  1. Photoisomerization of merocyanine 540 in polymer-surfactant ...

    Indian Academy of Sciences (India)

    Photoisomerization of merocyanine 540 (MC540) in a polymer-surfactant aggregate is studied using picosecond time resolved emission spectroscopy. The aggregate consists of the polymer, poly(vinylpyrrolidone) (PVP) and the surfactant, sodium dodecyl sulphate (SDS). With increase in the concentration of SDS in an ...

  2. Stilbazolium Merocyanine Dye Determination in Different Solutions, Concentrations and Colloids Using SERS

    DEFF Research Database (Denmark)

    Pajchrowski, Grzegorz; Abdali, Salim; Nørbygaard, Thomas

    2006-01-01

    Surface Enhanced Raman Scattering (SERS) measurements were carried out on stilbazolium merocyanine dye in methanol and pyridine solvents. Both solutions were measured in series of concentrations, covering a range of 5·10-5 M to 5·10-8 M. In these measurements Ag and Au colloids were used and the ......Surface Enhanced Raman Scattering (SERS) measurements were carried out on stilbazolium merocyanine dye in methanol and pyridine solvents. Both solutions were measured in series of concentrations, covering a range of 5·10-5 M to 5·10-8 M. In these measurements Ag and Au colloids were used...... report here on the success of using SERS to obtain Raman spectra of merocyanine dye at very low concentration in an attempt of new approach, which can be used for further investigations of the dye. The SERS spectra will here be reported and the results from different solutions, colloids, concentrations...

  3. One-pot three-component synthesis and photophysical characteristics of novel triene merocyanines

    Directory of Open Access Journals (Sweden)

    Christian Muschelknautz

    2014-03-01

    Full Text Available Novel triene merocyanines, i.e. 1-styryleth-2-enylidene and 4-(1,3,3-trimethylindolin-2-ylidenebut-2-en-1-ylideneindolones are obtained in good to excellent yields in a consecutive three-component insertion Sonogashira coupling–addition sequence. The selectivity of either series is remarkable and has its origin in the stepwise character of the terminal addition step as shown by extensive computations on the DFT level. All merocyanines display intense absorption bands in solution and the film spectra indicate J-aggregation. While 1-styryleth-2-enylideneindolones show an intense deep red emission in films, 4-(1,3,3-trimethylindolin-2-ylidenebut-2-en-1-ylideneindolones are essentially nonemissive in films or in the solid state. TD-DFT computations rationalize the charge-transfer nature of the characteristic broad long-wavelength absorptions bands.

  4. Limiting-dilution analysis for the determination of leukemic cell frequencies after bone marrow decontamination with mafosfamide or merocyanine 540

    Energy Technology Data Exchange (ETDEWEB)

    Porcellini, A.; Talevi, N.; Marchetti-Rossi, M.T.; Palazzi, M.; Manna, A.; Sparaventi, G.; Delfini, C.; Valentini, M.

    1987-11-01

    To stimulate a leukemia remission marrow, cell suspensions of normal human bone marrow were mixed with human acute lymphoblastic or myelogenous leukemic cells of the CCRF-SF, Nalm-6, and K-562 lines. The cell mixtures were incubated in vitro with mafosfamide (AZ) or with the photoreactive dye merocyanine 540 (MC-540). A quantity of 10(4) cells of the treated suspensions was dispensed into microculture plates, and graded cell numbers of the line used to contaminate the normal marrow were added. Limiting-dilution analysis was used to estimate the frequency of leukemia cells persisting after treatment with the decontaminating agents. Treatment with AZ or MC-540 produced a total elimination (ie, 6 logs or 5.3 logs respectively) of B cell acute leukemia cells (CCRF-SB), whereas nearly 1.7 logs and 2 logs of K-562 acute myelogenous blasts were still present in the cell mixtures after treatment with MC-540 and AZ, respectively. Treatment of the Nalm-6-contaminated cell mixtures with AZ resulted in 100% elimination of clonogenic cells, whereas nearly 80% decontamination was obtained with MC-540. Our results suggest that treatment with AZ could be an effective method of eliminating clonogenic tumor cells from human bone marrow. MC-540, shown by previous studies to spare sufficient pluripotential stem cells to ensure hemopoietic reconstitution in the murine model and in clinical application, has comparable effects and merits trials for possible clinical use in autologous bone marrow transplantation.

  5. Limiting-dilution analysis for the determination of leukemic cell frequencies after bone marrow decontamination with mafosfamide or merocyanine 540

    International Nuclear Information System (INIS)

    Porcellini, A.; Talevi, N.; Marchetti-Rossi, M.T.; Palazzi, M.; Manna, A.; Sparaventi, G.; Delfini, C.; Valentini, M.

    1987-01-01

    To stimulate a leukemia remission marrow, cell suspensions of normal human bone marrow were mixed with human acute lymphoblastic or myelogenous leukemic cells of the CCRF-SF, Nalm-6, and K-562 lines. The cell mixtures were incubated in vitro with mafosfamide (AZ) or with the photoreactive dye merocyanine 540 (MC-540). A quantity of 10(4) cells of the treated suspensions was dispensed into microculture plates, and graded cell numbers of the line used to contaminate the normal marrow were added. Limiting-dilution analysis was used to estimate the frequency of leukemia cells persisting after treatment with the decontaminating agents. Treatment with AZ or MC-540 produced a total elimination (ie, 6 logs or 5.3 logs respectively) of B cell acute leukemia cells (CCRF-SB), whereas nearly 1.7 logs and 2 logs of K-562 acute myelogenous blasts were still present in the cell mixtures after treatment with MC-540 and AZ, respectively. Treatment of the Nalm-6-contaminated cell mixtures with AZ resulted in 100% elimination of clonogenic cells, whereas nearly 80% decontamination was obtained with MC-540. Our results suggest that treatment with AZ could be an effective method of eliminating clonogenic tumor cells from human bone marrow. MC-540, shown by previous studies to spare sufficient pluripotential stem cells to ensure hemopoietic reconstitution in the murine model and in clinical application, has comparable effects and merits trials for possible clinical use in autologous bone marrow transplantation

  6. Inactivation of viruses in platelet suspensions that retain their in vitro characteristics: Comparison of psoralen-ultraviolet A and merocyanine 540-visible light methods

    International Nuclear Information System (INIS)

    Dodd, R.Y.; Moroff, G.; Wagner, S.; Dabay, M.H.; Dorfman, E.; George, V.; Ribeiro, A.; Shumaker, J.; Benade, L.E.

    1991-01-01

    The ability of two fundamentally different photochemical procedures to inactivate model viruses in platelet suspensions was compared. Merocyanine 540 (MC 540) with visible light was used as an example of an oxygen-dependent chemical-directed at the viral membrane, and aminomethyl trimethyl psoralen (AMT) with ultraviolet A light (UVA) was used as an example of a nucleic acid-directed system. Antiviral conditions in petri dishes were identified and the effects of these procedures on platelet suspensions in plastic storage containers were studied. Concentrations of photochemicals in the 10 to 150 mumol range with 30 to 60 minutes of visible light (MC 540) or 1 to 2 minutes of UVA (AMT) readily inactivated 5 to 6 log10 of vesicular stomatitis virus (VSV) and other model viruses in platelet suspensions, provided the plasma concentration was reduced to about 15 percent by the use of a synthetic platelet storage medium. Extracellular pH, morphology scores, and aggregation response dropped markedly when platelets were treated with MC 540 and visible light. However, treatment with 136 mumol per L of AMT and 1 to 3 minutes of UVA could inactivate 5 log10 of VSV in platelet suspensions with retention of platelet characteristics for 4 days, particularly if oxygen levels were reduced during treatment. These studies demonstrate that AMT-UVA treatment meets the initial requirements for virus inactivation in platelet suspensions

  7. The Social Attribution Task-Multiple Choice (SAT-MC): A Psychometric and Equivalence Study of an Alternate Form.

    Science.gov (United States)

    Johannesen, Jason K; Lurie, Jessica B; Fiszdon, Joanna M; Bell, Morris D

    2013-01-01

    The Social Attribution Task-Multiple Choice (SAT-MC) uses a 64-second video of geometric shapes set in motion to portray themes of social relatedness and intentions. Considered a test of "Theory of Mind," the SAT-MC assesses implicit social attribution formation while reducing verbal and basic cognitive demands required of other common measures. We present a comparability analysis of the SAT-MC and the new SAT-MC-II, an alternate form created for repeat testing, in a university sample (n = 92). Score distributions and patterns of association with external validation measures were nearly identical between the two forms, with convergent and discriminant validity supported by association with affect recognition ability and lack of association with basic visual reasoning. Internal consistency of the SAT-MC-II was superior (alpha = .81) to the SAT-MC (alpha = .56). Results support the use of SAT-MC and new SAT-MC-II as equivalent test forms. Demonstrating relatively higher association to social cognitive than basic cognitive abilities, the SAT-MC may provide enhanced sensitivity as an outcome measure of social cognitive intervention trials.

  8. Synthesis of merocyanines analogues based on the pyrazolin-5-one system

    International Nuclear Information System (INIS)

    Park, Soo Youl; Oh, Sea Wha

    2003-01-01

    The majority of dyes belong to the chromophoric class known as donor-acceptor systems. The essential structural feature of such systems is the presence of one or more electron donating groups conjugated to one or more electron withdrawing groups via an unsaturated bridge. The pyrazolin-5-one system is an effective electron acceptor residue, and can also act as a weak electron donor. In our experiments, the various symmetrical and unsymmetrical H-chromophores were synthesized in the indoxyl, imidazo(1,2-a)pyridin-2-one, pyrazolin-5-one, and pyridin-2-6-dione residues, resulting in cross-conjugated donor-acceptor systems. And the visible light absorption was then associated with the migration of electron density from the donor region of the molecule to the acceptor region. Also, it was useful to prepare related non-cross-conjugated donor acceptor chromophores by combining these residues with other electron donor or acceptor moieties. For convenience such chromophores are referred to as merocyanines

  9. Photophysical properties of a surfactive long-chain styryl merocyanine dye as fluorescent probe

    Energy Technology Data Exchange (ETDEWEB)

    Ismail, L.F.M., E-mail: Lailafmi@yahoo.com [Al-Azhar University, Faculty of Science, Chemistry Department, Nasr City, 12 Ibrahim El-Nagar, El-Hegaz Sq. Heliopolis, Cairo 11315 (Egypt)

    2012-09-15

    This work deals with detailed investigations of the photophysical properties of a styryl merocyanine dye, namely 1-cetyl-4-[4 Prime -(methoxy) styryl]-pyridinium bromide (CMSPB) of molecular rotor type. The solvatochromic analyses of the data in different solvents using the Kamlet-Taft parameters ({alpha}, {beta}, {pi}{sup Low-Asterisk }) were discussed. Optical excitation of the studied merocyanine dye populates a CT S{sub 1} state with about 22.64 folds higher dipole moment value relative to that in the S{sub 0} state. Moreover, the effect of solvent viscosity (glycerol at various temperatures (299.0-351.0 K)) on CMSPB fluorescent properties is analyzed to understand the molecular mechanisms of the characteristic increase in CMSPB fluorescence intensity. The results indicate that CMSPB exhibits fluorescent properties typical for molecular rotors. The results show that torsional relaxation dynamics of molecular rotors in high-viscosity solvents cannot be described by the simple stick boundary hydrodynamics defined by the Debye-Stokes-Einstein (DSE) equation. The fluorescence depolarization behavior in glycerol at various temperatures (299.0-351.0 K) shows that the molecular rotational diffusion is controlled by the free volume of the medium. Furthermore, excited state studies in ethanol/chloroform mixture revealed the formation of weak complex with chloroform of stoichiometry 1:1 with formation constant of 0.004l mol{sup -1}. Moreover, the increase of the quantum yield values in micellar solutions of CTAB and SDS relative to that of water indicates that the guest dye molecules are microencapsulated into the hydrophobic interior of host micelle. The obtained non-zero values of fluorescence polarization in micellar solution imply reduced rotational depolarization of dye molecules via association with the surfactant. Upon comparing the spectral data in micelles with those in homogeneous solvent systems, more can be learned of the structural details of the micellar

  10. Extraction of tributyltin and triphenyltin across a single oil droplet/water interface

    International Nuclear Information System (INIS)

    Chikama, Katsumi; Negishi, Takayuki; Nakatani, Kiyoharu

    2004-01-01

    Tributyltin (TBT + ) and triphenyltin (TPT + ) were extracted with merocyanine 540 (MC - ) from water into a 1,6-dichlorohexane droplet with the radius of 40 μm and the absorption spectra of MC - were measured by a single microdroplet manipulation and microabsorption technique. The mass transfer rate and the partitioning ratio of MC - were characteristically influenced by the TBT + , TPT + , MC - , and Cl - concentrations in water. The ion pair extraction processes of the organotin compounds with the anions were discussed in terms of the ion transfer and adsorption-desorption of the solutes

  11. Extraction of tributyltin and triphenyltin across a single oil droplet/water interface

    Energy Technology Data Exchange (ETDEWEB)

    Chikama, Katsumi; Negishi, Takayuki; Nakatani, Kiyoharu

    2004-07-01

    Tributyltin (TBT{sup +}) and triphenyltin (TPT{sup +}) were extracted with merocyanine 540 (MC{sup -}) from water into a 1,6-dichlorohexane droplet with the radius of 40 {mu}m and the absorption spectra of MC{sup -} were measured by a single microdroplet manipulation and microabsorption technique. The mass transfer rate and the partitioning ratio of MC{sup -} were characteristically influenced by the TBT{sup +}, TPT{sup +}, MC{sup -}, and Cl{sup -} concentrations in water. The ion pair extraction processes of the organotin compounds with the anions were discussed in terms of the ion transfer and adsorption-desorption of the solutes.

  12. Fluorescence quenching of fluorescein by Merocyanine 540 in liposomes

    International Nuclear Information System (INIS)

    Toprak, Mahmut; Meryem Aydin, Burcu; Arik, Mustafa; Onganer, Yavuz

    2011-01-01

    The fluorescence quenching of fluorescein (FL) by merociyanine 540 (MC540) was examined in L-egg lecithin phosphatidycholine (PC) liposomes using spectroscopic methods. The type of quenching mechanism (dynamic or static) was evaluated using the Stern-Volmer plots. Findings were also supported by the temperature studies and florescence decay measurements. The Stern-Volmer equation was utilized to calculate bimolecular quenching constants (K q ). Furthermore, the bimolecular quenching constant of the quencher in the liposomes (K SV ), partition coefficient (K p ), binding constant (K), and corresponding thermodynamic parameters ΔH, ΔS, and ΔG were calculated. The quenching property was also used in determining quantitatively (K p ) the partition coefficient of Merociyanini 540 in PC liposome.The obtained data indicated that static quenching occurred in the system and the K SV values decreased with increasing lipid concentration. In addition, thermodynamic analysis suggested that van der Waals interactions and hydrogen bonding were the main acting forces between fluorescein and merociyanine 540 molecules in the medium. - Highlights: → Fluorescence quenching of FL by MC540 in liposome system was analyzed. → Fluorescence quenching mechanism of FL by MC540 was consistent with the static model. → Binding FL to MC540 was spontaneous and carried out by hydrogen bond and van der Waals forces.

  13. Advances in Spiropyrans/Spirooxazines and Applications Based on Fluorescence Resonance Energy Transfer (FRET with Fluorescent Materials

    Directory of Open Access Journals (Sweden)

    Hongyan Xia

    2017-12-01

    Full Text Available Studies on the following were reviewed: (1 the structure of spiropyrans and spirooxazines (two kinds of spiro compounds under external stimuli and (2 the construction and applications of composite systems based on fluorescence resonance energy transfer (FRET with fluorescent materials. When treated with different stimuli (light, acids and bases, solvents, metal ions, temperature, redox potential, and so on, spiropyrans/spirooxazines undergo transformations between the ring-closed form (SP, the ring-opened merocyanine (MC form, and the protonated ring-opened form (MCH. This is due to the breakage of the spiro C–O bond and the protonation of MC, along with a color change. Various novel, multifunctional materials based on photochromic spiropyrans and spirooxazines have been successfully developed because of the vastly differently physiochemical properties posssed by the SP, MC and MCH forms. Among the three different structural forms, the MC form has been studied most extensively. The MC form not only gives complexes with various inorganic particles, biological molecules, and organic chemicals but also acts as the energy acceptor (of energy from fluorescent molecules during energy transfer processes that take place under proper conditions. Furthermore, spiropyran and spirooxazine compounds exhibit reversible physicochemical property changes under proper stimuli; this provides more advantages compared with other photochromic compounds. Additionally, the molecular structures of spiropyrans and spirooxazines can be easily modified and extended, so better compounds can be obtained to expand the scope of already known applications. Described in detail are: (1 the structural properties of spiropyrans and spirooxazines and related photochromic mechanisms; (2 composite systems based on spiropyrans and spirooxazines, and (3 fluorescent materials which have potential applications in sensing, probing, and a variety of optical elements.

  14. McSustainability and McJustice: Certification, Alternative Food and Agriculture, and Social Change

    Directory of Open Access Journals (Sweden)

    Maki Hatanaka

    2014-11-01

    Full Text Available Alternative food and agriculture movements increasingly rely on market-based approaches, particularly voluntary standards and certification, to advance environmental sustainability and social justice. Using a case study of an ecological shrimp project in Indonesia that became certified organic, this paper raises concerns regarding the impacts of certification on alternative food and agriculture movements, and their aims of furthering sustainability and justice. Drawing on George Ritzer’s McDonaldization framework, I argue that the ecological shrimp project became McDonaldized with the introduction of voluntary standards and certification. Specifically, efficiency, calculability, predictability, and control became key characteristics of the shrimp project. While the introduction of such characteristics increased market access, it also entailed significant costs, including an erosion of trust and marginalization and alienation of farmers. Given such tradeoffs, in concluding I propose that certification is producing particular forms of environmental sustainability and social justice, what I term McSustainability and McJustice. While enabling the expansion of alternative food and agriculture, McSustainability and McJustice tend to allow little opportunity for farmer empowerment and food sovereignty, as well as exclude aspects of sustainable farming or ethical production that are not easily measured, standardized, and validated.

  15. APLIKASI ANALISIS DISKRIMINAN DALAM MENENTUKAN KEPUTUSAN PEMBELIAN PRODUK McCafe (Studi Kasus: McDonald’s Jimbaran Bali

    Directory of Open Access Journals (Sweden)

    TRISNA RAMADHAN

    2018-02-01

    Full Text Available McDonald’s is one of fast food company that is growing rapidly. McDonald’s continues to innovate to satisfy customers. It introduced the concept of a cafe with the name McCafe. Because of the competition with other fast food restaurants, McDonald’s needs to improve the quality of McCafe favored by customers. Thus, this research was conducted to aim at getting the indicators that are best describing customers characteristic. This research used discriminant analysis methods. Discriminant analysis was used to classify customers into groups of loyal customers or non loyal customers.. The indicators that distinguished the decision of the customer to buy McCafe Jimbaran product were affordable prices and locations that are easily accessible to customers. The formed discriminant function had an accuracy of 91,67 percent in classifying the customers.

  16. The Embodied Subjectivity of a Half-Formed Narrator: Sexual Abuse, Language (Unformation and Melancholic Girlhood in Eimear McBride’s A Girl is a Half-Formed Thing

    Directory of Open Access Journals (Sweden)

    Shadia Abdel-Rahman Téllez

    2018-03-01

    Full Text Available Set in Ireland, in some undetermined time and place, Eimear McBride’s A Girl is a Half-formed Thing (2014 is a story about the crisis of identity of a nameless girl who has been sexually abused by her uncle in her teens. The aberrant sexualisation resulting from rape and the socially pre-established discourses of girlhood and womanhood provoke the fragmentation of the protagonist’s identity as a female subject and her transformation into a “half-formed thing”. McBride tries to capture this process of half-formation by means of language and other experimental narrative strategies, which are a clear legacy of modernism and the works by female writers from the Celtic Tiger period. The violent world, in which the main character is under the rule of her authoritative mother and predatory uncle, contrasts with the loving relationship with her terminally ill brother. The melancholic experiences of shame and guilt invade the Girl’s sense of embodied identity and interfere with the process of becoming an individual. The death of her brother is the ultimate trigger for the half-formed girl to disengage permanently from her “sinful” body, opening the possibility of an alternative mode of being in the world. The analysis of this novel-long stream-of-consciousness focuses on the narration of the conflicts with corporeality, abnormal sexualisation, the dissolution of subjectivity and failure to regain agency over a powerless body.

  17. McStas

    DEFF Research Database (Denmark)

    Willendrup, Peter Kjær; Farhi, Emmanuel; Bergbäck Knudsen, Erik

    2014-01-01

    experiments. McStas is being actively used for the design-update of the European Spallation Source (ESS) in Lund. This paper includes an introduction to the McStas package, recent and ongoing simulation projects. Further, new features in releases McStas 1.12c and 2.0 are discussed.......The McStas neutron ray-tracing simulation package is a collaboration between Risø DTU, ILL, University of Copenhagen and the PSI. During its lifetime, McStas has evolved to become the world leading software in the area of neutron scattering simulations for instrument design, optimisation, virtual...

  18. Experience in Collaboration: McDenver at McDonald's.

    Science.gov (United States)

    Combs, Clarice Sue

    2002-01-01

    The McDenver at McDonald's project provided a nontraditional, community-based teaching and learning environment for faculty and students in a health, physical education, and recreation (HPER) department and a school of nursing. Children and parents come to McDonald's, children received developmental screenings, and parents completed conferences…

  19. Opening a spiropyran ring by way of an exciplex intermediate.

    Science.gov (United States)

    Benniston, Andrew C; Harriman, Anthony; Howell, Sarah L; Li, Peiyi; Lydon, Donocadh P

    2007-02-02

    A molecular dyad has been synthesized in which the main chromophore is a 1,4-diethynylated benzene residue terminated with pyrene moieties, this latter unit acting as a single chromophore. A spiropyran group has been condensed to the central phenylene ring so as to position a weak electron donor close to the pyrene unit. Illumination of the pyrene-based chromophore leads to formation of a fluorescent exciplex in polar solvents but pyrene-like fluorescence is observed in nonpolar solvents. The exciplex has a lifetime of a few nanoseconds and undergoes intersystem crossing to the pyrene-like triplet state with low efficiency. Attaching a 4-nitrobenzene group to the open end of the spiropyran unit creates a new route for decay of the exciplex whereby the triplet state of the spiropyran is formed. Nonradiative decay of this latter species results in ring opening to form the corresponding merocyanine species. Rate constants for the various steps have been obtained from time-resolved fluorescence spectroscopy carried out over a modest temperature range. Under visible light illumination, the merocyanine form reverts to the original spiropyran geometry so that the cycle is closed. Energy transfer from the pyrene chromophore to the merocyanine unit leads to an increased rate of ring closure and serves to push the steady-state composition in favor of the spiropyran form.

  20. Design of Thermochromic Polynorbornene Bearing Spiropyran Chromophore Moieties: Synthesis, Thermal Behavior and Dielectric Barrier Discharge Plasma Treatment

    Directory of Open Access Journals (Sweden)

    Saleh A. Ahmed

    2017-11-01

    Full Text Available A new class of thermochromic polynorbornene with pendent spiropyran moieties has been synthesized. Functionalization of norbornene monomers with spirobenzopyran moieties has been achieved using Steglich esterification. These new monomeric materials were polymerized via Ring Opening Metathesis Polymerization (ROMP. In spite of their poor solubility, polynorbornenes with spirobenzopyran exhibited thermochromic behavior due to the conversion of their closed spiropyran moieties to the open merocyanine form. Moreover, these polymers displayed bathochromic shifts in their optical response, which was attributed to the J-aggregation of the attached merocyanine moieties that were associated with their high concentration in the polymeric chain. The surface of the obtained polymers was exposed to atmospheric pressure air Dielectric Barrier Discharge (DBD plasma system, which resulted in the reduction of the surface porosity and converted some surface area into completely non-porous regions. Moreover, the plasma system created some areas with highly ordered J-aggregates of the merocyanine form in thread-like structures. This modification of the polymers’ morphology may alter their applications and allow for these materials to be potential candidates for new applications, such as non-porous membranes for reverse osmosis, nanofiltration, or molecular separation in the gas phase.

  1. EVALUATING CHAMBERLAIN'S, McGREGOR'S, AND McRAE'S ...

    African Journals Online (AJOL)

    2012-08-08

    Aug 8, 2012 ... spine and base of skull radiographs which however have diagnostic challenges due to the complexity of the ... McGregor's and Mc Rae's using CT bone windows ... metastatic lesion were excluded from the study. RESULTS.

  2. McDonald's vs Father Christmas

    Science.gov (United States)

    Pratt, Dave; Simpson, Amanda

    2004-01-01

    Mathematics in textbooks and indeed in conventional classrooms is often presented as exercises or worksheets in which the mathematics itself has been processed into a form that is easily digested. This McDonald's version of mathematics ensures that the mathematical skill or technique is laid bare and typically the sole focus of attention. In this…

  3. Qualification of McCARD/MASTER Code System for Yonggwang Unit 4

    International Nuclear Information System (INIS)

    Park, Ho Jin; Shim, Hyung Jin; Joo, Han Gyu; Kim, Chang Hyo

    2011-01-01

    Recently, we have developed the new two-step procedure based on the Monte Carlo (MC) methods. In this procedure, one can generate the few group constants including the few-group diffusion constants by the MC method augmented by the critical spectrum, which is provided by the solution to the homogeneous 0-dimensional B1 equation. In order to examine the qualification of the few-group constants generated by MC method, we combine MASTER with McCARD to form McCARD/MASTER code system for two-step core neutronics calculations. In the fictitious PWR system problems, the core design parameters calculated by the two-step McCARD/MASTER analysis agree well with those from the direct MC calculations. In this paper, a neutronic design analysis for the initial core of Yonggwang Nuclear Unit 4 (YGN4) is conducted using McCARD/MASTER two-step procedure to examine the qualification of two group constants from McCARD in terms of a real PWR core problem. To compare with the results, the nuclear design report and measured data are chosen as the reference solutions

  4. Alumina-Forming Austenitic Stainless Steels Strengthened by Laves Phase and MC Carbide Precipitates

    Science.gov (United States)

    Yamamoto, Y.; Brady, M. P.; Lu, Z. P.; Liu, C. T.; Takeyama, M.; Maziasz, P. J.; Pint, B. A.

    2007-11-01

    Creep strengthening of Al-modified austenitic stainless steels by MC carbides or Fe2Nb Laves phase was explored. Fe-20Cr-15Ni-(0-8)Al and Fe-15Cr-20Ni-5Al base alloys (at. pct) with small additions of Nb, Mo, W, Ti, V, C, and B were cast, thermally-processed, and aged. On exposure from 650 °C to 800 °C in air and in air with 10 pct water vapor, the alloys exhibited continuous protective Al2O3 scale formation at an Al level of only 5 at. pct (2.4 wt pct). Matrices of the Fe-20Cr-15Ni-5Al base alloys consisted of γ (fcc) + α (bcc) dual phase due to the strong α-Fe stabilizing effect of the Al addition and exhibited poor creep resistance. However, adjustment of composition to the Fe-15Cr-20Ni-5Al base resulted in alloys that were single-phase γ-Fe and still capable of alumina scale formation. Alloys that relied solely on Fe2Nb Laves phase precipitates for strengthening exhibited relatively low creep resistance, while alloys that also contained MC carbide precipitates exhibited creep resistance comparable to that of commercially available heat-resistant austenitic stainless steels. Phase equilibria studies indicated that NbC precipitates in combination with Fe2Nb were of limited benefit to creep resistance due to the solution limit of NbC within the γ-Fe matrix of the alloys studied. However, when combined with other MC-type strengtheners, such as V4C3 or TiC, higher levels of creep resistance were obtained.

  5. ExMC Technology Watch

    Science.gov (United States)

    Krihak, M.; Barr, Y.; Watkins, S.; Fung, P.; McGrath, T.; Baumann, D.

    2012-01-01

    . Second, a RASC-AL (Revolutionary Aerospace Systems Concepts - Academic Linkage) topic for FY12 was developed for medical systems and astronaut health under the Human-Focused Mars Mission Systems and Technologies theme. Announcement of the competition was made to the public in August 2011. Finally, critical Tech Watch information was prepared for public release in the form of gap reports. Complementing the ExMC technology gaps in the public domain, gap reports were generated, reviewed and revised through a series of technical, medical and subject matter expert reviews before approval for public release. An important vehicle for the public release of such documents was development of the ExMC wiki website, which will continue to be populated with gap reports and relevant documents throughout the upcoming year.

  6. McKenzie River Subbasin Assessment, Summary Report 2000.

    Energy Technology Data Exchange (ETDEWEB)

    Alsea Geospatial, Inc.

    2000-02-01

    This document summarizes the findings of the McKenzie River Subbasin Assessment: Technical Report. The subbasin assessment tells a story about the McKenzie River watershed. What is the McKenzie's ecological history, how is the McKenzie doing today, and where is the McKenzie watershed headed ecologically? Knowledge is a good foundation for action. The more we know, the better prepared we are to make decisions about the future. These decisions involve both protecting good remaining habitat and repairing some of the parts that are broken in the McKenzie River watershed. The subbasin assessment is the foundation for conservation strategy and actions. It provides a detailed ecological assessment of the lower McKenzie River and floodplain, identifies conservation and restoration opportunities, and discusses the influence of some upstream actions and processes on the study area. The assessment identifies restoration opportunities at the reach level. In this study, a reach is a river segment from 0.7 to 2.7 miles long and is defined by changes in land forms, land use, stream junctions, and/or cultural features. The assessment also provides flexible tools for setting priorities and planning projects. The goal of this summary is to clearly and concisely extract the key issues, findings, and recommendations from the full-length Technical Report. The high priority recommended action items highlight areas that the McKenzie Watershed Council can significantly influence, and that will likely yield the greatest ecological benefit. People are encouraged to read the full Technical Report if they are interested in the detailed methods, findings, and references used in this study.

  7. Depletion layer characteristics and photovoltaic energy conversion in organic P-N heterojunctions

    Energy Technology Data Exchange (ETDEWEB)

    Chamberlain, G A

    1983-11-01

    The depletion layer characteristics of an organic p-n heterojunction were investigated by measuring the temperature variation of the capacitance, rectification and photovoltaic short-circuit current and open-circuit voltage. The cell consisted of indium-tin-oxide-coated glass/n-type malachite green/p-type merocyanine/Au exposed to chlorine vapour, in the absence of air, to effect the marked rectification and photovoltaic properties observed. Capacitance measurements indicate that a depletion layer of about 65 nm and a barrier height of about 0.8 eV are formed between the two dyes. The forward dark current is dominated by electron tunnelling from the malachite green to the merocyanine. Using an asymmetric trapping model, the reverse saturation current was explained as the thermally activated emission of electrons from filled traps at the Fermi energy of the merocyanine to empty traps in the malachite green over a barrier of 0.72+-0.1 eV. When the cell is working in the photovoltaic mode, the photocurrent is limited by the poor carrier photogeneration efficiency in the malachite green.

  8. Corrections to O(α7(lnα)mc2) fine-structure splittings and O(α6(lnα)mc2) energy levels in helium

    International Nuclear Information System (INIS)

    Zhang, T.

    1996-01-01

    Fully relativistic formulas for the energy-level shifts arising from no-pair exchange diagrams of two transverse photons plus an arbitrary number of Coulomb photons are derived in closed form within the external potential Bethe-Salpeter formalism. O(α 7 (lnα)mc 2 ) corrections to the fine-structure splittings of helium are obtained and expressed in terms of expectation values of nonrelativistic operators. O(α 7 mc 2 ) operators from exchange diagrams are found in nonrelativistic approximation. O(α 6 m 2 c 2 /M) nucleus-electron operators contributing to the fine-structure splittings are derived. Nonrelativistic operators of O(α 6 mc 2 ) corrections to the triplet levels of helium are presented. Nonrelativistic operators of O(α 6 (lnα)mc 2 ) corrections to the helium singlet levels and to positronium S levels are derived. O(α 6 m 2 c 2 /M) hydrogen and O(α 6 mc 2 ) positronium P levels, and O(α 6 (lnα)mc 2 ) corrections of first order to positronium S levels, are calculated using the derived operators for helium, in agreement with those obtained previously by others, except for one term in corrections to positronium P levels. In addition, the O(α 6 mc 2 ) Dirac energies for hydrogenic non-S levels are exactly reproduced in a perturbative calculation. copyright 1996 The American Physical Society

  9. Reversible photoluminescence in spiropyran-modified porous silicon

    International Nuclear Information System (INIS)

    Lee, Chen-Yu; Hu, Chih-Hsuan; Cheng, Sheng-Lin; Chu, Chih-Chien; Hsiao, Vincent K.S.

    2015-01-01

    Spiropyran-modified porous silicon (spiro-PS) was used for the first time as an organic–inorganic hybrid material by using reversible photoluminescence (PL). Before spiropyran modification, the peak wavelength from PS was approximately 600 nm. Subsequent spiropyran modification strongly quenched the PL intensity, from 15,000 to 2000 counts. However, under UV light irradiation, the PL intensity from spiro-PS was increased gradually to 20,000 counts because of the photoinduced ring opening from a colorless spiropyran (SP-form) to a colored merocyanine (MC-form). Furthermore, the resulting peak wavelength of the PL of an MC–PS sample red-shifted from 600 to 650 nm, and the PL intensity was higher than that of unmodified PS. Because the fluorescence emission band (500–700 nm) of PS substantially overlapped the absorption band (500–700 nm) of the MC-form of spiropyran, the energy transfer from the PS (donor) to the open-ring-state MC-form (acceptor) occurs efficiently. The intensity of the PL from spiro-PS can be reversibly modulated using a heat stimulus. The current demonstrations have potential in reversible solid-state lighting or data storage applications. - Highlights: • Spiropyran-modified porous silicon (spiro-PS) was used for the first time as an organic–inorganic hybrid material with reversible photoluminescence (PL). • UV light irradiation make PL intensity from spiro-PS increased due to the photo-induced ring opening process. • The energy transfer from the PS (donor) to the open-ring state of spiropyran (acceptor) was to be efficient due to the fluorescence emission band of PS substantially overlapped with the absorption band of the ring-opened spiro. • The intensity of the PL from spiro-PS can be reversibly modulated using a heat stimulus

  10. THE McELIECE CRYPTOSYSTEM WITH ARRAY CODES

    Directory of Open Access Journals (Sweden)

    Vedat Şiap

    2011-12-01

    Full Text Available Public-key cryptosystems form an important part of cryptography. In these systems, every user has a public and a private key. The public key allows other users to encrypt messages, which can only be decoded using the secret private key. In that way, public-key cryptosystems allow easy and secure communication between all users without the need to actually meet and exchange keys. One such system is the McEliece Public-Key cryptosystem, sometimes also called McEliece Scheme. However, as we live in the information age, coding is used in order to protecet or correct the messages in the transferring or the storing processes. So, linear codes are important in the transferring or the storing. Due to richness of their structure array codes which are linear are also an important codes. However, the information is then transferred into the source more securely by increasing the error correction capability with array codes. In this paper, we combine two interesting topics, McEliece cryptosystem and array codes.

  11. α-Skew π-McCoy Rings

    Directory of Open Access Journals (Sweden)

    Areej M. Abduldaim

    2013-01-01

    Full Text Available As a generalization of α-skew McCoy rings, we introduce the concept of α-skew π-McCoy rings, and we study the relationships with another two new generalizations, α-skew π1-McCoy rings and α-skew π2-McCoy rings, observing the relations with α-skew McCoy rings, π-McCoy rings, α-skew Armendariz rings, π-regular rings, and other kinds of rings. Also, we investigate conditions such that α-skew π1-McCoy rings imply α-skew π-McCoy rings and α-skew π2-McCoy rings. We show that in the case where R is a nonreduced ring, if R is 2-primal, then R is an α-skew π-McCoy ring. And, let R be a weak (α,δ-compatible ring; if R is an α-skew π1-McCoy ring, then R is α-skew π2-McCoy.

  12. MC 68020 μp architecture

    International Nuclear Information System (INIS)

    Casals, O.; Dejuan, E.; Labarta, J.

    1988-01-01

    The MC68020 is a 32-bit microprocessor object code compatible with the earlier MC68000 and MC68010. In this paper we describe its architecture and two coprocessors: the MC68851 paged memory management unit and the MC68882 floating point coprocessor. Between its most important characteristics we can point up: addressing mode extensions for enhanced support of high level languages, an on-chip instruction cache and full support of virtual memory. (Author)

  13. Improved algorithms and advanced features of the CAD to MC conversion tool McCad

    International Nuclear Information System (INIS)

    Lu, L.; Fischer, U.; Pereslavtsev, P.

    2014-01-01

    Highlights: •The latest improvements of the McCad conversion approach including decomposition and void filling algorithms is presented. •An advanced interface for the materials editing and assignment has been developed and added to the McCAD GUI. •These improvements have been tested and successfully applied to DEMO and ITER NBI (Neutral Beam Injector) applications. •The performance of the CAD model conversion process is shown to be significantly improved. -- Abstract: McCad is a geometry conversion tool developed at KIT to enable the automatic bi-directional conversions of CAD models into the Monte Carlo (MC) geometries utilized for neutronics calculations (CAD to MC) and, reversed (MC to CAD), for visualization purposes. The paper presents the latest improvements of the conversion algorithms including improved decomposition, void filling and an advanced interface for the materials editing and assignment. The new implementations and features were tested on fusion neutronics applications to the DEMO and ITER NBI (Neutral Beam Injector) models. The results demonstrate greater stability and enhanced efficiency of McCad conversion process

  14. McMYB12 Transcription Factors Co-regulate Proanthocyanidin and Anthocyanin Biosynthesis in Malus Crabapple

    OpenAIRE

    Tian, Ji; Zhang, Jie; Han, Zhen-yun; Song, Ting-ting; Li, Jin-yan; Wang, Ya-ru; Yao, Yun-cong

    2017-01-01

    The flavonoid compounds, proanthocyanidins (PAs), protect plants from biotic stresses, contribute to the taste of many fruits, and are beneficial to human health in the form of dietary antioxidants. In this study, we functionally characterized two Malus crabapple R2R3-MYB transcription factors, McMYB12a and McMYB12b, which co-regulate PAs and anthocyanin biosynthesis. McMYB12a was shown to be mainly responsible for upregulating the expression of anthocyanin biosynthetic genes by binding to th...

  15. Medical Genetics at McGill: The History of a Pioneering Research Group.

    Science.gov (United States)

    Canning, Christopher; Weisz, George; Tone, Andrea; Cambrosio, Alberto

    2013-01-01

    The McGill Group in Medical Genetics was formed in 1972, supported by the Medical Research Council and successor Canadian Institutes for Health Research until September 2009, making it the longest active biomedical research group in the history of Canada. We document the history of the McGill Group and situate its research within a broader history of medical genetics. Drawing on original oral histories with the Group's members, surviving documents, and archival materials, we explore how the Group's development was structured around epistemological trends in medical genetics, policy choices made by research agencies, and the development of genetics at McGill University and its hospitals.

  16. Occurrence of the Microcystins MC-LW and MC-LF in Dutch Surface Waters and Their Contribution to Total Microcystin Toxicity

    Directory of Open Access Journals (Sweden)

    Elisabeth J. Faassen

    2013-07-01

    Full Text Available Microcystins (MCs are the most frequently found cyanobacterial toxins in freshwater systems. Many MC variants have been identified and variants differ in their toxicity. Recent studies showed that the variants MC-LW and MC-LF might be more toxic than MC-LR, the variant that is most abundant and mostly used for risk assessments. As little is known about the presence of these two variants in The Netherlands, we determined their occurrence by analyzing 88 water samples and 10 scum samples for eight MC variants ((dm-7-MC-RR, MC-YR, (dm-7-MC-LR, MC-LY, MC-LW and MC-LF by liquid chromatography with tandem mass spectrometry detection. All analyzed MC variants were detected, and MC-LW and/or MC-LF were present in 32% of the MC containing water samples. When MC-LW and MC-LF were present, they contributed to nearly 10% of the total MC concentrations, but due to their suspected high toxicity, their average contribution to the total MC toxicity was estimated to be at least 45%. Given the frequent occurrence and possible high toxicity of MC-LW and MC-LF, it seems better to base health risk assessments on the toxicity contributions of different MC variants than on MC-LR concentrations alone.

  17. Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors

    DEFF Research Database (Denmark)

    Holst, Birgitte; Elling, Christian E; Schwartz, Thue W

    2002-01-01

    -melanocortin stimulating hormone (alpha-MSH) in the MC1 and MC4 receptors, respectively. In the presence of peptide agonist, Zn(II) acted as an enhancer on both receptors, because it shifted the dose-response curves to the left: most pronounced was a 6-fold increase in alpha-MSH potency on the MC1 receptor. The effect......An endogenous metal-ion site in the melanocortin MC1 and MC4 receptors was characterized mainly in transiently transfected COS-7 cells. ZnCl(2) alone stimulated signaling through the Gs pathway with a potency of 11 and 13 microm and an efficacy of 50 and 20% of that of alpha...... affinities and profiles were similar for a number of the 2,2'-bipyridine and 1,10-phenanthroline analogs in complex with Zn(II) in the MC1 and MC4 receptors. However, the potencies and efficacies of the metal-ion complexes were very different in the two receptors, and close to full agonism was obtained...

  18. MC++: A parallel, portable, Monte Carlo neutron transport code in C++

    International Nuclear Information System (INIS)

    Lee, S.R.; Cummings, J.C.; Nolen, S.D.

    1997-01-01

    MC++ is an implicit multi-group Monte Carlo neutron transport code written in C++ and based on the Parallel Object-Oriented Methods and Applications (POOMA) class library. MC++ runs in parallel on and is portable to a wide variety of platforms, including MPPs, SMPs, and clusters of UNIX workstations. MC++ is being developed to provide transport capabilities to the Accelerated Strategic Computing Initiative (ASCI). It is also intended to form the basis of the first transport physics framework (TPF), which is a C++ class library containing appropriate abstractions, objects, and methods for the particle transport problem. The transport problem is briefly described, as well as the current status and algorithms in MC++ for solving the transport equation. The alpha version of the POOMA class library is also discussed, along with the implementation of the transport solution algorithms using POOMA. Finally, a simple test problem is defined and performance and physics results from this problem are discussed on a variety of platforms

  19. ERSN-OpenMC, a Java-based GUI for OpenMC Monte Carlo code

    Directory of Open Access Journals (Sweden)

    Jaafar EL Bakkali

    2016-07-01

    Full Text Available OpenMC is a new Monte Carlo transport particle simulation code focused on solving two types of neutronic problems mainly the k-eigenvalue criticality fission source problems and external fixed fission source problems. OpenMC does not have any Graphical User Interface and the creation of one is provided by our java-based application named ERSN-OpenMC. The main feature of this application is to provide to the users an easy-to-use and flexible graphical interface to build better and faster simulations, with less effort and great reliability. Additionally, this graphical tool was developed with several features, as the ability to automate the building process of OpenMC code and related libraries as well as the users are given the freedom to customize their installation of this Monte Carlo code. A full description of the ERSN-OpenMC application is presented in this paper.

  20. Electric Vehicle Performance at McMurdo Station (Antarctica) and Comparison with McMurdo Station Conventional Vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Sears, T.; Lammert, M.; Colby, K.; Walter, R.

    2014-09-01

    This report examines the performance of two electric vehicles (EVs) at McMurdo, Antarctica (McMurdo). The study examined the performance of two e-ride Industries EVs initially delivered to McMurdo on February 16, 2011, and compared their performance and fuel use with that of conventional vehicles that have a duty cycle similar to that of the EVs used at McMurdo.

  1. Alex McQueen : power

    Index Scriptorium Estoniae

    1998-01-01

    A. McQueeni moevälisest tegevusest. 'American Express' tellis temalt krediitkaardi kujunduse. 1998. a. suvest ajakirja 'Dazed & Confused' abitoimetaja. A. McQueen on lubanud olla Björki (Island) video kunstiline juht.

  2. McUniversities Revisited: A Comparison of University and McDonald's Casual Employee Experiences in Australia

    Science.gov (United States)

    Nadolny, Andrew; Ryan, Suzanne

    2015-01-01

    The McDonaldization of higher education refers to the transformation of universities from knowledge generators to rational service organizations or "McUniversities". This is reflected in the growing dependence on a casualized academic workforce. The article explores the extent to which the McDonaldization thesis applies to universities…

  3. McRunjob: A High Energy Physics Workflow Planner for Grid Production Processing

    CERN Document Server

    Graham, G E; Bertram, I; Graham, Gregory E.; Evans, Dave; Bertram, Iain

    2003-01-01

    McRunjob is a powerful grid workflow manager used to manage the generation of large numbers of production processing jobs in High Energy Physics. In use at both the DZero and CMS experiments, McRunjob has been used to manage large Monte Carlo production processing since 1999 and is being extended to uses in regular production processing for analysis and reconstruction. Described at CHEP 2001, McRunjob converts core metadata into jobs submittable in a variety of environments. The powerful core metadata description language includes methods for converting the metadata into persistent forms, job descriptions, multi-step workflows, and data provenance information. The language features allow for structure in the metadata by including full expressions, namespaces, functional dependencies, site specific parameters in a grid environment, and ontological definitions. It also has simple control structures for parallelization of large jobs. McRunjob features a modular design which allows for easy expansion to new job d...

  4. Hydrologic Process Parameterization of Electrical Resistivity Imaging of Solute Plumes Using POD McMC

    Science.gov (United States)

    Awatey, M. T.; Irving, J.; Oware, E. K.

    2016-12-01

    Markov chain Monte Carlo (McMC) inversion frameworks are becoming increasingly popular in geophysics due to their ability to recover multiple equally plausible geologic features that honor the limited noisy measurements. Standard McMC methods, however, become computationally intractable with increasing dimensionality of the problem, for example, when working with spatially distributed geophysical parameter fields. We present a McMC approach based on a sparse proper orthogonal decomposition (POD) model parameterization that implicitly incorporates the physics of the underlying process. First, we generate training images (TIs) via Monte Carlo simulations of the target process constrained to a conceptual model. We then apply POD to construct basis vectors from the TIs. A small number of basis vectors can represent most of the variability in the TIs, leading to dimensionality reduction. A projection of the starting model into the reduced basis space generates the starting POD coefficients. At each iteration, only coefficients within a specified sampling window are resimulated assuming a Gaussian prior. The sampling window grows at a specified rate as the number of iteration progresses starting from the coefficients corresponding to the highest ranked basis to those of the least informative basis. We found this gradual increment in the sampling window to be more stable compared to resampling all the coefficients right from the first iteration. We demonstrate the performance of the algorithm with both synthetic and lab-scale electrical resistivity imaging of saline tracer experiments, employing the same set of basis vectors for all inversions. We consider two scenarios of unimodal and bimodal plumes. The unimodal plume is consistent with the hypothesis underlying the generation of the TIs whereas bimodality in plume morphology was not theorized. We show that uncertainty quantification using McMC can proceed in the reduced dimensionality space while accounting for the

  5. Validation of a short form of the Western Ontario and McMaster Universities Osteoarthritis Index function subscale in hip and knee osteoarthritis.

    Science.gov (United States)

    Baron, Gabriel; Tubach, Florence; Ravaud, Philippe; Logeart, Isabelle; Dougados, Maxime

    2007-05-15

    A short version of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) function scale has recently been developed to enhance the applicability of the scale in routine practice and clinical research for patients with hip and knee osteoarthritis. The goal of the present study was to validate this short form. We conducted a prospective 4-week cohort study of 1,036 outpatients. Performance on the WOMAC function long form (LF) and short form (SF) was compared. Agreement between responses on the 2 forms was examined according to a Bland-Altman plot. Responsiveness to change (by standardized response mean [SRM]), reproducibility (intraclass correlation coefficient [ICC]), and internal consistency (Cronbach's alpha) were computed for both forms. Construct validity was assessed based on functional impairment as measured on a numerical rating scale. At baseline, 24% of patients who completed the WOMAC LF had missing data for at least 1 item as compared with only 6% of patients who completed the WOMAC SF. The mean WOMAC SF score was greater than the mean WOMAC LF score (mean +/- SD difference -4.3 +/- 4.8 on a 0-100 scale). SRMs were 0.61 and 0.73, ICCs were 0.76 and 0.68, and Cronbach's alphas were 0.93 and 0.85 for the WOMAC LF and SF, respectively. The 2 forms had comparable correlation with functional impairment. The WOMAC function short form has a low rate of missing data and is a responsive, reproducible, and valid measure. The mean SF score was 4 points higher than the mean LF score.

  6. 75 FR 27286 - McKelvie Geographic Area Range Allotment Management Planning on the Samuel R. McKelvie National...

    Science.gov (United States)

    2010-05-14

    ... range allotment management planning on the McKelvie Geographic Area, Samuel R. McKelvie National Forest... DEPARTMENT OF AGRICULTURE Forest Service McKelvie Geographic Area Range Allotment Management Planning on the Samuel R. McKelvie National Forest, Bessey Ranger District in Nebraska AGENCY: Forest...

  7. McMYB12 Transcription Factors Co-regulate Proanthocyanidin and Anthocyanin Biosynthesis in Malus Crabapple.

    Science.gov (United States)

    Tian, Ji; Zhang, Jie; Han, Zhen-Yun; Song, Ting-Ting; Li, Jin-Yan; Wang, Ya-Ru; Yao, Yun-Cong

    2017-03-03

    The flavonoid compounds, proanthocyanidins (PAs), protect plants from biotic stresses, contribute to the taste of many fruits, and are beneficial to human health in the form of dietary antioxidants. In this study, we functionally characterized two Malus crabapple R2R3-MYB transcription factors, McMYB12a and McMYB12b, which co-regulate PAs and anthocyanin biosynthesis. McMYB12a was shown to be mainly responsible for upregulating the expression of anthocyanin biosynthetic genes by binding to their promoters, but to be only partially responsible for regulating PAs biosynthetic genes. In contrast, McMYB12b showed preferential binding to the promoters of PAs biosynthetic genes. Overexpression of McMYB12a and McMYB12b in tobacco (Nicotiana tabacum) altered the expression of flavonoid biosynthetic genes and promoted the accumulation of PAs and anthocyanins in tobacco petals. Conversely, transient silencing their expression in crabapple plants, using a conserved gene region, resulted in reduced PAs and anthocyanin production a green leaf phenotype. Meanwhile, transient overexpression of the two genes and silenced McMYB12s in apple (Malus domestica) fruit had a similar effect as overexpression in tobacco and silenced in crabapple. This study reveals a new mechanism for the coordinated regulation of PAs and anthocyanin accumulation in crabapple leaves, which depends on an auto-regulatory balance involving McMYB12a and McMYB12b expression.

  8. Corporate communication or McCommunication? Considering a McDonaldization of corporate communication hypothesis

    NARCIS (Netherlands)

    Verhoeven, P.

    2015-01-01

    In this essay the perspective of Ritzer's McDonaldization of Society Thesis is the starting point for developing hypotheses about corporate communication (CorpCom). The central idea of McDonaldization is that increasing numbers of organizations are run as fast food restaurants, focusing on:

  9. Michel Trottier-McDonald

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics. Michel Trottier-McDonald. Articles written in Pramana – Journal of Physics. Volume 79 Issue 5 November 2012 pp 1337-1340 Poster Presentations. Tau reconstruction, energy calibration and identification at ATLAS · Michel Trottier-McDonald on behalf of the ATLAS ...

  10. Dynamics of transfer of electron excitation in a donor-acceptor system with a carbon chain and ways of its relaxation

    Directory of Open Access Journals (Sweden)

    M.M. Sevryukova

    2017-12-01

    Full Text Available The optical properties and dynamics of transport of electron excitation and the ways of its relaxation in the supramolecular D–π–A complex on the basis of merocyanines have been investigated. There have been found two components in the transfer of charge: fast and slow, which correspond to different conformational states of the carbon chain in merocyanines. It was found that the main photoluminescence of the studied molecular solutions of merocyanines by its nature is similar to the exciplex luminescence, as a manifestation of resonant and charge transfer interaction in an excited state. The lifetime in this state is about 2000 ps.

  11. Realizing tunable molecular thermal devices based on photoisomerism—Is it possible?

    Energy Technology Data Exchange (ETDEWEB)

    Ranganathan, Raghavan; Sasikumar, Kiran; Keblinski, Pawel, E-mail: keblip@rpi.edu [Department of Materials Science and Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180 (United States)

    2015-01-14

    In this work, we address the question if it is possible to tune the thermal conductance through photoisomerism-capable molecular junctions. Using non-equilibrium molecular dynamics simulations, we study heat flow due to phonons between two silicon leads connected via two classes of photoisomeric molecules—(a) azobenzene and (b) Spiropyran (SP)–Merocyanine (MC) isomers. For the case of azobenzene, isomeric states with different conformations are realized via mechanical strain, while in the case of SP-MC, via a hybridization change. Based on the phononic contribution to thermal conductance, we observe that the thermal conductance of both junctions is rather insensitive to the isomeric state, thereby rendering the tunability of molecular thermal devices rather difficult. Consistent with these observations, the vibrational density of states for different configurations yields very similar spectra. We note that including the effect of electronic contribution to thermal conductance could enhance the tunability of thermal properties, albeit weakly.

  12. The Effects of Spatial Diversity and Imperfect Channel Estimation on Wideband MC-DS-CDMA and MC-CDMA

    Science.gov (United States)

    2009-10-01

    In our previous work, we compared the theoretical bit error rates of multi-carrier direct sequence code division multiple access (MC- DS - CDMA ) and...consider only those cases where MC- CDMA has higher frequency diversity than MC- DS - CDMA . Since increases in diversity yield diminishing gains, we conclude

  13. Qualification test of few group constants generated from an MC method by the two-step neutronics analysis system McCARD/MASTER

    International Nuclear Information System (INIS)

    Park, Ho Jin; Shim, Hyung Jin; Joo, Han Gyu; Kim, Chang Hyo

    2011-01-01

    The purpose of this paper is to examine the qualification of few group constants estimated by the Seoul National University Monte Carlo particle transport analysis code McCARD in terms of core neutronics analyses and thus to validate the McCARD method as a few group constant generator. The two- step core neutronics analyses are conducted for a mini and a realistic PWR by the McCARD/MASTER code system in which McCARD is used as an MC group constant generation code and MASTER as a diffusion core analysis code. The two-step calculations for the effective multiplication factors and assembly power distributions of the two PWR cores by McCARD/MASTER are compared with the reference McCARD calculations. By showing excellent agreements between McCARD/MASTER and the reference MC core neutronics analyses for the two PWRs, it is concluded that the MC method implemented in McCARD can generate few group constants which are well qualified for high-accuracy two-step core neutronics calculations. (author)

  14. The McDonaldization of Higher Education.

    Science.gov (United States)

    Hayes, Dennis, Ed.; Wynyard, Robin, Ed.

    The essays in this collection discuss the future of the university in the context of the "McDonaldization" of society and of academia. The idea of McDonaldization, a term coined by G. Ritzer (1998), provides a tool for looking at the university and its inevitable changes. The chapters are: (1) "Enchanting McUniversity: Toward a…

  15. Helium trapping at Ti-rich MC particles in Ti-modified austenitic stainless steel

    International Nuclear Information System (INIS)

    Maziasz, P.J.

    1980-01-01

    Helium trapping by Ti-rich MC particles is characterized by first, the formation of a high concentration of tiny cavities at the interfaces and secondly, a cavity denuded zone that extends into the surrounding matrix. Very few cavities form on other phases in the system when MC is present. The trapping is effective in HFIR from at least 370 to 600 0 C. The phases produced in unmodified steel do not exhibit this type of strong helium trapping. This trapping helps minimize the swelling for a given amount of helium. Compositionally, MC is strongly enriched in Ti, Mo, V, and Nb and depleted in Si, Ni, Cr, and Fe, both thermally and after irradiation in HFIR. The compositional behavior of MC is unusual because phases that are stabilized by irradiation are generally enriched in Si and/or Ni. The data are obtained using quantitative x-ray EDS for particles on extraction replicas. The microstructural and compositional information is examined with respect to concepts or trends from several theories to begin to understand the nature of the helium trapping

  16. Cytotoxicity of Titanate-Calcium Complexes to MC3T3 Osteoblast-Like Cells

    Science.gov (United States)

    Drury, Jeanie L.; Moussi, Joelle; Taylor-Pashow, Kathryn M. L.

    2016-01-01

    Monosodium titanates (MST) are a relatively novel form of particulate titanium dioxide that have been proposed for biological use as metal sorbents or delivery agents, most recently calcium (II). In these roles, the toxicity of the titanate or its metal complex is crucial to its biological utility. The aim of this study was to determine the cytotoxicity of MST and MST-calcium complexes with MC3T3 osteoblast-like cells; MST-Ca(II) complexes could be useful to promote bone formation in various hard tissue applications. MC3T3 cells were exposed to native MST or MST-Ca(II) complexes for 24–72 h. A CellTiter-Blue® assay was employed to assess the metabolic activity of the cells. The results showed that MST and MST-Ca(II) suppressed MC3T3 metabolic activity significantly in a dose-, time-, and cell-density-dependent fashion. MST-Ca(II) suppressed MC3T3 metabolism in a statistically identical manner as native MST at all concentrations. We concluded that MST and MST-Ca(II) are significantly cytotoxic to MC3T3 cells through a mechanism yet unknown; this is a potential problem to the biological utility of these complexes. PMID:28044136

  17. Cytotoxicity of Titanate-Calcium Complexes to MC3T3 Osteoblast-Like Cells

    Directory of Open Access Journals (Sweden)

    Yen-Wei Chen

    2016-01-01

    Full Text Available Monosodium titanates (MST are a relatively novel form of particulate titanium dioxide that have been proposed for biological use as metal sorbents or delivery agents, most recently calcium (II. In these roles, the toxicity of the titanate or its metal complex is crucial to its biological utility. The aim of this study was to determine the cytotoxicity of MST and MST-calcium complexes with MC3T3 osteoblast-like cells; MST-Ca(II complexes could be useful to promote bone formation in various hard tissue applications. MC3T3 cells were exposed to native MST or MST-Ca(II complexes for 24–72 h. A CellTiter-Blue® assay was employed to assess the metabolic activity of the cells. The results showed that MST and MST-Ca(II suppressed MC3T3 metabolic activity significantly in a dose-, time-, and cell-density-dependent fashion. MST-Ca(II suppressed MC3T3 metabolism in a statistically identical manner as native MST at all concentrations. We concluded that MST and MST-Ca(II are significantly cytotoxic to MC3T3 cells through a mechanism yet unknown; this is a potential problem to the biological utility of these complexes.

  18. McStas and Mantid integration

    DEFF Research Database (Denmark)

    Nielsen, T. R.; Markvardsen, A. J.; Willendrup, Peter Kjær

    2015-01-01

    McStas and Mantid are two well-established software frameworks within the neutron scattering community. McStas has been primarily used for simulating the neutron transport mechanisms in instruments, while Mantid has been primarily used for data reduction. We report here the status of our work don...

  19. The MC4 receptor and control of appetite

    NARCIS (Netherlands)

    Adan, R. A. H.; Tiesjema, B.; Hillebrand, J. J. G.; La Fleur, S. E.; Kas, M. J. H.; de Krom, M.

    2006-01-01

    Mutations in the human melanocortin (MC)4 receptor have been associated with obesity, which underscores the relevance of this receptor as a drug target to treat obesity. Infusion of MC4R agonists decreases food intake, whereas inhibition of MC receptor activity by infusion of an MC receptor

  20. Evidence that multiple genetic variants of MC4R play a functional role in the regulation of energy expenditure and appetite in Hispanic children

    Science.gov (United States)

    Melanocortin-4-receptor (MC4R) haploinsufficiency is the most common form of monogenic obesity; however, the frequency of MC4R variants and their functional effects in general populations remain uncertain. The aim of this study was to identify and characterize the effects of MC4R variants in Hispani...

  1. Ilusões de modernidade: o fetiche da marca McDonald's no Brasil Illusions of modernity: the fetish of McDonald's' brand in Brazil

    Directory of Open Access Journals (Sweden)

    Isleide Arruda Fontenelle

    2006-08-01

    Full Text Available Objetiva-se apresentar e discutir as relações atuais entre imagem e entretenimento a partir de pesquisas realizadas sobre a construção da imagem de marca McDonald's e sobre as modernas técnicas de marketing. Visando compreender porque nos tornamos consumidores de imagens, procurou-se recuperar, a partir da própria historia do McDonald's, os acontecimentos econômicos, sociais, culturais, políticos, que teriam nos transformado em uma sociedade na qual "estar na imagem é existir". Embora trágica em seu sentido de fundo, essa perda da forma nos é compensada por imagens de diversão e felicidade que as marcas nos transmitem. Ao final, questiona-se o alcance global dessa promessa a partir de uma digressão sobre o Brasil: como a marca McDonald's nos fornece as imagens para uma certa constituição identitária; e o seu nome para um sentimento de permanência? Como falar de "identificação" com uma marca que, aparentemente, não teria uma relação histórica e cultural com o Brasil?This article presents and discusses the current relationship between image and entertainment, based on the results of research studies on the constitution of McDonald's' brand image all over the world and contemporary marketing. Aiming to understand why we have become image consumers, those studies tried to recover, based on McDonald's history, economical, social, cultural, and political events that have lead us towards an obsessed image society, in which, "being in the image is the same as existing". Although tragic in its bottom line, that inexistence of form is compensated to us by amusement and happiness images conveyed by the brands. Finally, the research questions the global reach of that promise, starting from a digression on Brazil: how does McDonald's' brand supply us images for a certain identity constitution; and its brand name for a permanence feeling? How is it possible to speak of "identification" with a brand that, seemingly, would not have a

  2. Examples of MC and A systems to meet prompt accountability specifications

    Energy Technology Data Exchange (ETDEWEB)

    Eggers, R F; Brouns, R J; Bryant, J L; Davenport, L C; Brite, D W; Kinnison, R R; Fager, J E; Williams, R C; Wilson, R L

    1983-01-01

    Proposed regulations for NRC licensees authorized to possess and process formula quantities of strategic special nuclear material (SSNM) would require each licensee to implement a material control and accounting (MC and A) system capable of prompt loss detection and alarm resolution. In support of the loss detection and alarm response activities an overcheck program would also be implemented. This program would include personnel qualification and training, quality control, inventory verification and shipper-receiver transaction verification. However, the frequeny of physical inventory verification would be about once per year rather than once every two months. In addition MC and A activities would include procedures for the prevention and detection of data falsification and other forms of deceit that might undermine the performance of the loss detection and response systems. This report provides examples of prompt accountability systems for four plants: mixed oxide fuel fabrication, uranium hexafluoride conversion, high enriched uranium fuel fabrication, and high enriched uranium scrap recovery. Purpose of this report is to provide guidance to the MC and A system designer and evaluator on how the proposed requirements might be met.

  3. Examples of MC and A systems to meet prompt accountability specifications

    International Nuclear Information System (INIS)

    Eggers, R.F.; Brouns, R.J.; Bryant, J.L.; Davenport, L.C.; Brite, D.W.; Kinnison, R.R.; Fager, J.E.; Williams, R.C.; Wilson, R.L.

    1983-01-01

    Proposed regulations for NRC licensees authorized to possess and process formula quantities of strategic special nuclear material (SSNM) would require each licensee to implement a material control and accounting (MC and A) system capable of prompt loss detection and alarm resolution. In support of the loss detection and alarm response activities an overcheck program would also be implemented. This program would include personnel qualification and training, quality control, inventory verification and shipper-receiver transaction verification. However, the frequeny of physical inventory verification would be about once per year rather than once every two months. In addition MC and A activities would include procedures for the prevention and detection of data falsification and other forms of deceit that might undermine the performance of the loss detection and response systems. This report provides examples of prompt accountability systems for four plants: mixed oxide fuel fabrication, uranium hexafluoride conversion, high enriched uranium fuel fabrication, and high enriched uranium scrap recovery. Purpose of this report is to provide guidance to the MC and A system designer and evaluator on how the proposed requirements might be met

  4. Barbara McClintock, Jumping Genes, and Transposition

    Science.gov (United States)

    McClintock Honored * Woman of Science * Educational Material * Resources with Additional Information Barbara McClintock's remarkable life spanned the history of genetics in the twentieth century. ... [T]he science of Dedicate Famous Scientist Stamps ... Woman of Science: McClintock, Barbara and the Jumping Genes, 4,000

  5. Shaping ability of NT Engine and McXim rotary nickel-titanium instruments in simulated root canals. Part 1.

    Science.gov (United States)

    Thompson, S A; Dummer, P M

    1997-07-01

    The aim of this study was to determine the shaping ability of NT Engine and McXim nickel-titanium rotary instruments in simulated root canals. In all, 40 canals consisting of four different shapes in terms of angle and position of curvature were prepared by a combination of NT Engine and McXim instruments using the technique recommended by the manufacturer. Part 1 of this two-part report describes the efficacy of the instruments in terms of preparation time, instrument failure, canal blockages, loss of canal length and three-dimensional canal form. Overall, the mean preparation time for all canals was 6.01 min, with canal shape having a significant effect (P Engine and McXim instruments prepared canals rapidly, with few deformations, no canal blockages and with minimal change in working length. The three-dimensional form of the canals demonstrated good flow and taper characteristics.

  6. Comparison of the Effect of Dry Cupping Therapy and Acupressure at BL23 Point on Intensity of Postpartum Perineal Pain Based on the Short Form of McGill Pain Questionnaire.

    Science.gov (United States)

    Akbarzade, Marzieh; Ghaemmaghami, Mehrnoush; Yazdanpanahi, Zahra; Zare, Najaf; Mohagheghzadeh, Abdolali; Azizi, Amir

    2016-01-01

    Perineal pain is a major morbidity in the first few days after delivery. This study aimed to investigate the effect of dry cupping therapy and acupressure at BL23 point on the intensity of postpartum perineal pain based on the short-form of McGill pain questionnaire (SMPQ). The present clinical trial was conducted on 150 subjects in 3 groups of 50 cases. After at least 4-8 hr of delivery, cupping therapy was performed for 15-20 min up to 3 times a week (once a day) and acupressure was performed for 15-20 min based on clockwise model. The short-form of McGill pain questionnaire was completed both before and after the intervention. The SPSS statistical software was used to analyze the data using repeated measures ANOVA. Besides, pcupping therapy group, mean of the perineal pain intensity reduced from 37.5±6.8 before the intervention to 11.1±6.1, 6.9±4.7, and 3.8±3.6 immediately, 24 hr, and 2 weeks after the intervention, respectively. The results of study showed that the differences between the intervention and control groups were statistically significant (pcupping therapy and acupressure reduced perineal pain. Therefore, they may be considered as effective treatments for reducing pain intensity of allowing delivery.

  7. ProMC: Input-output data format for HEP applications using varint encoding

    Science.gov (United States)

    Chekanov, S. V.; May, E.; Strand, K.; Van Gemmeren, P.

    2014-10-01

    A new data format for Monte Carlo (MC) events, or any structural data, including experimental data, is discussed. The format is designed to store data in a compact binary form using variable-size integer encoding as implemented in the Google's Protocol Buffers package. This approach is implemented in the PROMC library which produces smaller file sizes for MC records compared to the existing input-output libraries used in high-energy physics (HEP). Other important features of the proposed format are a separation of abstract data layouts from concrete programming implementations, self-description and random access. Data stored in PROMC files can be written, read and manipulated in a number of programming languages, such C++, JAVA, FORTRAN and PYTHON.

  8. Workshop for development of formal MC and A plans

    International Nuclear Information System (INIS)

    Erkkila, B.H.; Hatcher, C.R.; Scott, S.C.; Thomas, K.E.

    1998-01-01

    Upgrades to both physical protection and material controls and accountability (MC and A) are progressing at many nuclear facilities in the Russian Federation. In general, Russian facilities are well prepared to address issues related to physical protection. The infrastructure to plan and implement physical protection upgrades is already in place in Russia. The infrastructure to integrate new and existing MC and A capabilities is not as well developed. The authors experience has shown that working with Russian facility management and technical personnel to draft an MC and A plan provides a way of moving MC and A upgrades forward. Los Alamos has developed a workshop for Russian nuclear facilities to facilitate the preparation of their facility MC and A plans. The workshops have been successful in bringing together facility management, safeguards specialists, and operations personnel to initiate the process of drafting these MC and A plans. The MC and A plans provide the technical basis for scheduling future MC and A upgrades at the facilities. Although facility MC and A plans are site specific, the workshop can be tailored to guide the development of an MC and A plan for any Russian nuclear site

  9. McDonald’s Corporation - 2015 (MCD)

    OpenAIRE

    Alen Badal

    2017-01-01

    McDonald’s Corporation, 2015 is aiming to enlighten the “Experience of the Future” for consumers, with a special focus on the ‘younger’ generation. Beginning in 2015 and moving forward, McDonald’s has operationalized the functions of its strategy to bett er serve consumers with such offerings as trial-testing a build-your-burger strategy with the order being served at the table, known as the “Create Your Taste” program. The restaurant chain has introduced the all-day breakfast menu and ‘McPic...

  10. Adolescent Purchasing Behavior at McDonald's and Subway.

    Science.gov (United States)

    Lesser, Lenard I; Kayekjian, Karen C; Velasquez, Paz; Tseng, Chi-Hong; Brook, Robert H; Cohen, Deborah A

    2013-10-01

    To assess whether adolescents purchasing food at a restaurant marketed as "healthy" (Subway) purchase fewer calories than at a competing chain (McDonald's). We studied 97 adolescents who purchased a meal at both restaurants on different days, using each participant as his or her control. We compared the difference in calories purchased by adolescents at McDonald's and Subway in a diverse area of Los Angeles, CA. Adolescents purchased an average of 1,038 calories (standard error of the mean [SEM]: 41) at McDonald's and 955 calories (SEM 39) at Subway. The difference of 83 calories (95% confidence interval [CI]: -20 to 186) was not statistically significant (p = .11). At McDonald's, participants purchased significantly more calories from drinks (151 vs. 61, p McDonald's vs. 35 at Subway, p McDonald's (.15 vs. .57 cups, p McDonald's. Although Subway meals had more vegetables, meals from both restaurants are likely to contribute to overeating. Copyright © 2013 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  11. McXtrace

    DEFF Research Database (Denmark)

    Bergbäck Knudsen, Erik; Prodi, Andrea; Baltser, Jana

    2013-01-01

    to the standard X-ray simulation software SHADOW. McXtrace is open source, licensed under the General Public License, and does not require the user to have access to any proprietary software for its operation. The structure of the software is described in detail, and various examples are given to showcase...

  12. Smart Fluid System Dually Responsive to Light and Electric Fields: An Electrophotorheological Fluid.

    Science.gov (United States)

    Yoon, Chang-Min; Jang, Yoonsun; Noh, Jungchul; Kim, Jungwon; Jang, Jyongsik

    2017-10-24

    Electrophotorheological (EPR) fluids, whose rheological activity is dually responsive to light and electric fields (E fields), is formulated by mixing photosensitive spiropyran-decorated silica (SP-sSiO 2 ) nanoparticles with zwitterionic lecithin and mineral oil. A reversible photorheological (PR) activity of the EPR fluid is developed via the binding and releasing mechanism of lecithin and merocyanine (MC, a photoisomerized form of SP) under ultraviolet (UV) and visible (VIS) light applications. Moreover, the EPR fluid exhibits an 8-fold higher electrorheological (ER) performance compared to the SP-sSiO 2 nanoparticle-based ER fluid (without lecithin) under an E field, which is attributed to the enhanced dielectric properties facilitated by the binding of the lecithin and SP molecules. Upon dual application of UV light and an E field, the EPR fluid exhibits high EPR performance (ca. 115.3 Pa) that far exceeds its separate PR (ca. 0.8 Pa) and ER (ca. 57.5 Pa) activities, because of the synergistic contributions of the PR and ER effects through rigid and fully connected fibril-like structures. Consequently, this study offers a strategy on formulation of dual-stimuli responsive smart fluid systems.

  13. Rotated Walsh-Hadamard Spreading with Robust Channel Estimation for a Coded MC-CDMA System

    Directory of Open Access Journals (Sweden)

    Raulefs Ronald

    2004-01-01

    Full Text Available We investigate rotated Walsh-Hadamard spreading matrices for a broadband MC-CDMA system with robust channel estimation in the synchronous downlink. The similarities between rotated spreading and signal space diversity are outlined. In a multiuser MC-CDMA system, possible performance improvements are based on the chosen detector, the channel code, and its Hamming distance. By applying rotated spreading in comparison to a standard Walsh-Hadamard spreading code, a higher throughput can be achieved. As combining the channel code and the spreading code forms a concatenated code, the overall minimum Hamming distance of the concatenated code increases. This asymptotically results in an improvement of the bit error rate for high signal-to-noise ratio. Higher convolutional channel code rates are mostly generated by puncturing good low-rate channel codes. The overall Hamming distance decreases significantly for the punctured channel codes. Higher channel code rates are favorable for MC-CDMA, as MC-CDMA utilizes diversity more efficiently compared to pure OFDMA. The application of rotated spreading in an MC-CDMA system allows exploiting diversity even further. We demonstrate that the rotated spreading gain is still present for a robust pilot-aided channel estimator. In a well-designed system, rotated spreading extends the performance by using a maximum likelihood detector with robust channel estimation at the receiver by about 1 dB.

  14. Interobserver agreement on Poser's and the new McDonald's diagnostic criteria for multiple sclerosis.

    Science.gov (United States)

    Zipoli, V; Portaccio, E; Siracusa, G; Pracucci, G; Sorbi, S; Amato, M P

    2003-10-01

    We assessed the interobserver agreement on the diagnosis of multiple sclerosis (MS) in a study sample consisting of 41 MS (15 relapsing remitting, two secondary progressive, five primary progressive and 19 presenting their first clinical attack) and three non-MS cases. Clinical and paraclinical information was recorded in standardized forms. Four neurologists were asked to make a diagnosis using Poser's and McDonald's criteria and to assess MRI scans according to the McDonald's guidelines. In terms of the kappa statistic (kappa), we found a moderate agreement on the overall diagnosis using both Poser's and McDonald's criteria (kappa, respectively 0.57 and 0.52). As for distinct diagnostic categories, we observed a moderate to substantial agreement for the three McDonald categories (range of kappa values 0.49-0.64) and a fair to substantial agreement for the nine Poser categories (range of kappa values 0.37-0.67). Taking into account clinical information, the agreement on dissemination over time was substantially higher (kappa = 0.69) than that found on dissemination over space (kappa = 0.46). In contrast, for MRI assessment, the agreement for spatial dissemination was substantial (kappa = 0.74) compared with the fair agreement (kappa = 0.25) yielded by dissemination over time. The new McDonald's criteria yield a good overall diagnostic reliability, and compare favourably with Poser's classification in terms of agreement on distinct diagnostic categories.

  15. MC Carbide Characterization in High Refractory Content Powder-Processed Ni-Based Superalloys

    Science.gov (United States)

    Antonov, Stoichko; Chen, Wei; Huo, Jiajie; Feng, Qiang; Isheim, Dieter; Seidman, David N.; Sun, Eugene; Tin, Sammy

    2018-04-01

    Carbide precipitates in Ni-based superalloys are considered to be desirable phases that can contribute to improving high-temperature properties as well as aid in microstructural refinement of the material; however, they can also serve as crack initiation sites during fatigue. To date, most of the knowledge pertaining to carbide formation has originated from assessments of cast and wrought Ni-based superalloys. As powder-processed Ni-based superalloys are becoming increasingly widespread, understanding the different mechanisms by which they form becomes increasingly important. Detailed characterization of MC carbides present in two experimental high Nb-content powder-processed Ni-based superalloys revealed that Hf additions affect the resultant carbide morphologies. This morphology difference was attributed to a higher magnitude of elastic strain energy along the interface associated with Hf being soluble in the MC carbide lattice. The composition of the MC carbides was studied through atom probe tomography and consisted of a complex carbonitride core, which was rich in Nb and with slight Hf segregation, surrounded by an Nb carbide shell. The characterization results of the segregation behavior of Hf in the MC carbides and the subsequent influence on their morphology were compared to density functional theory calculations and found to be in good agreement, suggesting that computational modeling can successfully be used to tailor carbide features.

  16. McMYB10 regulates coloration via activating McF3'H and later structural genes in ever-red leaf crabapple.

    Science.gov (United States)

    Tian, Ji; Peng, Zhen; Zhang, Jie; Song, Tingting; Wan, Huihua; Zhang, Meiling; Yao, Yuncong

    2015-09-01

    The ever-red leaf trait, which is important for breeding ornamental and higher anthocyanin plants, rarely appears in Malus families, but little is known about the regulation of anthocyanin biosynthesis involved in the red leaves. In our study, HPLC analysis showed that the anthocyanin concentration in ever-red leaves, especially cyanidin, was significantly higher than that in evergreen leaves. The transcript level of McMYB10 was significantly correlated with anthocyanin synthesis between the 'Royalty' and evergreen leaf 'Flame' cultivars during leaf development. We also found the ever-red leaf colour cultivar 'Royalty' contained the known R6 : McMYB10 sequence, but was not in the evergreen leaf colour cultivar 'Flame', which have been reported in apple fruit. The distinction in promoter region maybe is the main reason why higher expression level of McMYB10 in red foliage crabapple cultivar. Furthermore, McMYB10 promoted anthocyanin biosynthesis in crabapple leaves and callus at low temperatures and during long-day treatments. Both heterologous expression in tobacco (Nicotiana tabacum) and Arabidopsis pap1 mutant, and homologous expression in crabapple and apple suggested that McMYB10 could promote anthocyanins synthesis and enhanced anthocyanin accumulation in plants. Interestingly, electrophoretic mobility shift assays, coupled with yeast one-hybrid analysis, revealed that McMYB10 positively regulates McF3'H via directly binding to AACCTAAC and TATCCAACC motifs in the promoter. To sum up, our results demonstrated that McMYB10 plays an important role in ever-red leaf coloration, by positively regulating McF3'H in crabapple. Therefore, our work provides new perspectives for ornamental fruit tree breeding. © 2015 Society for Experimental Biology, Association of Applied Biologists and John Wiley & Sons Ltd.

  17. McSUB V2.0, an upgraded version of the Monte Carlo library McSUB with inclusion of weight factors

    International Nuclear Information System (INIS)

    Hoek, M.

    1991-02-01

    The Monte Carlo library McSUB, which was described in an earlier report, has been upgraded to McSUB V2.0. McSUB V2.0 can be used to simulate the neutron transport in a medium which is a mixture of hydrogen and carbon or a mixture of deuterium and carbon. The implemented neutron energy interval is 0.1 - 20 MeV and the library can be used to simulate elastic and inelastic scattering. The inelastic scattering with carbon takes into account the four lowest excited states of the carbon nucleus. McSUB V2.0 is downward compatible with McSUB expect for the layout of the parameter file which now contains more variables. The major upgrade has been the inclusion of routines using weight factors which has speeded up the old version considerably. McSUB V2.0 also makes a biasing technique possible. It is now possible to e.g. let a neutron scatter with a selected nucleus followed by a biased scattering direction. (au)

  18. Thermal behavior of J-aggregates in a Langmuir-Blodgett film of pure merocyanine dye investigated by UV-visible and IR absorption spectroscopy.

    Science.gov (United States)

    Hirano, Yoshiaki; Tateno, Shinsuke; Maio, Ari; Ozaki, Yukihiro

    2009-03-05

    We have characterized the structure of J-aggregate in a Langmuir-Blodgett film of pure merocyanine dye (MS18) fabricated under an aqueous subphase containing a cadmium ion (Cd2+) and have investigated its thermal behavior by UV-visible and IR absorption spectroscopy in the range from 25 to 250 degrees C with a continuous scan. The results of both UV-visible and IR absorption spectra indicate that temperature-dependent changes in the MS18 aggregation state in the pure MS18 system are closely and mildly linked with the MS18 intramolecular charge transfer and the behavior of the packing, orientation, conformation, and thermal mobility of MS18 hydrocarbon chain, respectively. The J-aggregate in the pure MS18 system dissociates from 25 to 150 degrees C, and the dissociation temperature at 150 degrees C is higher by 50 degrees C than that in the previous MS18- arachidic acid (C20) binary system. The lower dissociation temperature in the binary system originates from the fact that temperature-dependent structural disorder of cadmium arachidate (CdC20), being phase-separated from MS18, has an influence on the dissociation of J-aggregate. From 160 to 180 degrees C, thermally induced blue-shifted bands, caused by the oligomeric MS18 aggregation, appear at around 520 nm in the pure MS18 system by contraries, regardless of the lack of driving force by the melting phenomenon of CdC20. The temperature at which the 520 nm bands occur is in good agreement with the melting point (160 degrees C) of hydrocarbon chain in MS18 with Cd2+, whereas its chromophore part is clearly observed to melt near 205 degrees C by UV-visible spectra. Therefore, it is suggested that the driving force that induces the 520 nm band in the pure MS18 system arises from the partial melting of hydrocarbon chain in MS18 with Cd2+.

  19. Adaptation and heterogeneity of Escherichia coli MC1000 growing in complex environments

    DEFF Research Database (Denmark)

    Puentes-Téllez, Pilar; Hansen, Martin Asser; Sørensen, Søren

    2013-01-01

    In a study aiming to assess bacterial evolution in complex growth media, we evaluated the long-term adaptive response of Escherichia coli MC1000 in Luria-Bertani (LB) medium. Seven parallel populations were founded and followed over 150 days in sequential batch cultures under three different oxygen...... conditions (defined environments), and 19 evolved forms were isolated. The emergence of forms with enhanced fitness was evident in competition experiments of all evolved forms versus the ancestral strain. The evolved forms were then subjected to phenotypic and genomic analyses relative to the ancestor...... in galR, a repressor of the galactose operon. Concomitantly, the new forms revealed enhanced growth on galactose as well as galactose-containing disaccharides. This response was likely driven by the LB medium....

  20. Discrete Time McKean–Vlasov Control Problem: A Dynamic Programming Approach

    Energy Technology Data Exchange (ETDEWEB)

    Pham, Huyên, E-mail: pham@math.univ-paris-diderot.fr; Wei, Xiaoli, E-mail: tyswxl@gmail.com [Laboratoire de Probabilités et Modèles Aléatoires, CNRS, UMR 7599, Université Paris Diderot (France)

    2016-12-15

    We consider the stochastic optimal control problem of nonlinear mean-field systems in discrete time. We reformulate the problem into a deterministic control problem with marginal distribution as controlled state variable, and prove that dynamic programming principle holds in its general form. We apply our method for solving explicitly the mean-variance portfolio selection and the multivariate linear-quadratic McKean–Vlasov control problem.

  1. Discrete Time McKean–Vlasov Control Problem: A Dynamic Programming Approach

    International Nuclear Information System (INIS)

    Pham, Huyên; Wei, Xiaoli

    2016-01-01

    We consider the stochastic optimal control problem of nonlinear mean-field systems in discrete time. We reformulate the problem into a deterministic control problem with marginal distribution as controlled state variable, and prove that dynamic programming principle holds in its general form. We apply our method for solving explicitly the mean-variance portfolio selection and the multivariate linear-quadratic McKean–Vlasov control problem.

  2. The McClean Lake uranium project

    International Nuclear Information System (INIS)

    Blaise, J.R.

    2001-01-01

    The McClean Lake Uranium Project, located in the northern part of Saskatchewan, consists of five uranium deposits, Jeb - Sue A - Sue B - Sue C - McClean, scattered in three different locations on the mineral lease. On 16 March 1995, COGEMA Resources Inc and its partners, Denison Mines Ltd and OURD (Canada) Co Ltd, made the formal decision to develop the McClean Lake Project. Construction of the mine and mill started during summer 1995 and should be finished by mid 1997. Mining of the first deposit, Jeb started in 1996, ore being currently mined. The start of the yellowcake production is scheduled to start this fall. (author)

  3. Implatation of MC2 computer code

    International Nuclear Information System (INIS)

    Seehusen, J.; Nair, R.P.K.; Becceneri, J.C.

    1981-01-01

    The implantation of MC2 computer code in the CDC system is presented. The MC2 computer code calculates multigroup cross sections for tipical compositions of fast reactors. The multigroup constants are calculated using solutions of PI or BI approximations for determined buckling value as weighting function. (M.C.K.) [pt

  4. Reliability of McConnell's classification of patellar orientation in symptomatic and asymptomatic subjects.

    Science.gov (United States)

    Watson, C J; Propps, M; Galt, W; Redding, A; Dobbs, D

    1999-07-01

    Test-retest reliability study with blinded testers. To determine the intratester reliability of the McConnell classification system and to determine whether the intertester reliability of this system would be improved by one-on-one training of the testers, increasing the variability and numbers of subjects, blinding the testers to the absence or presence of patellofemoral pain syndrome, and adhering to the McConnell classification system as it is taught in the "McConnell Patellofemoral Treatment Plan" continuing education course. The McConnell classification system is currently used by physical therapy clinicians to quantify static patellar orientation. The measurements generated from this system purportedly guide the therapist in the application of patellofemoral tape and in assessment of the efficacy of treatment interventions on changing patellar orientation. Fifty-six subjects (age range, 21-65 years) provided a total of 101 knees for assessment. Seventy-six knees did not produce symptoms. A researcher who did not participate in the measuring process determined that 17 subjects had patellofemoral pain syndrome in 25 knees. Two testers concurrently measured static patellar orientation (anterior/posterior and medial/lateral tilt, medial/lateral glide, and patellar rotation) on subjects, using the McConnell classification system. Repeat measures were performed 3-7 days later. A kappa (kappa) statistic was used to assess the degree of agreement within each tester and between testers. The kappa coefficients for intratester reliability varied from -0.06 to 0.35. Intertester reliability ranged from -0.03 to 0.19. The McConnell classification system, in its current form, does not appear to be very reliable. Intratester reliability ranged from poor to fair, and intertester reliability was poor to slight. This system should not be used as a measurement tool or as a basis for treatment decisions.

  5. Age McCanni büroo = Offices of Age McCann

    Index Scriptorium Estoniae

    2010-01-01

    Tallinnas Rotermanni 8 asuva Age McCanni büroo sisekujundusest. Sisekujunduse autorid: sisearhitekt Kerli Valk (Kukuhaus OÜ) ja arhitekt Tomomi Hayashi (HG Arhitektuur OÜ), nende tähtsamate tööde loetelu

  6. MC and A system design workshop

    International Nuclear Information System (INIS)

    Schneider, R.A.; Harms, N.L.

    1984-01-01

    The workshop had as its goal the development of a Material Control and Accounting (MC and A) system for a low enriched uranium fuel fabrication plant. The factors to be considered for each of the ten key elements of the safeguards (MC and A) are presented in the text for the session

  7. A Causal Inference Model Explains Perception of the McGurk Effect and Other Incongruent Audiovisual Speech.

    Directory of Open Access Journals (Sweden)

    John F Magnotti

    2017-02-01

    Full Text Available Audiovisual speech integration combines information from auditory speech (talker's voice and visual speech (talker's mouth movements to improve perceptual accuracy. However, if the auditory and visual speech emanate from different talkers, integration decreases accuracy. Therefore, a key step in audiovisual speech perception is deciding whether auditory and visual speech have the same source, a process known as causal inference. A well-known illusion, the McGurk Effect, consists of incongruent audiovisual syllables, such as auditory "ba" + visual "ga" (AbaVga, that are integrated to produce a fused percept ("da". This illusion raises two fundamental questions: first, given the incongruence between the auditory and visual syllables in the McGurk stimulus, why are they integrated; and second, why does the McGurk effect not occur for other, very similar syllables (e.g., AgaVba. We describe a simplified model of causal inference in multisensory speech perception (CIMS that predicts the perception of arbitrary combinations of auditory and visual speech. We applied this model to behavioral data collected from 60 subjects perceiving both McGurk and non-McGurk incongruent speech stimuli. The CIMS model successfully predicted both the audiovisual integration observed for McGurk stimuli and the lack of integration observed for non-McGurk stimuli. An identical model without causal inference failed to accurately predict perception for either form of incongruent speech. The CIMS model uses causal inference to provide a computational framework for studying how the brain performs one of its most important tasks, integrating auditory and visual speech cues to allow us to communicate with others.

  8. McClean Lake. Site Guide

    International Nuclear Information System (INIS)

    2016-09-01

    Located over 700 kilometers northeast of Saskatoon, Areva's McClean Lake site is comprised of several uranium mines and one of the most technologically advanced uranium mills in the world - the only mill designed to process high-grade uranium ore without dilution. Areva has operated several open-pit uranium mines at the McClean Lake site, and is evaluating future mines at and near the site. The McClean Lake mill has recently undergone a multimillion-dollar upgrade and expansion, which has doubled its annual production capacity of uranium concentrate to 24 million pounds. It is the only facility in the world capable of processing high-grade uranium ore without diluting it. The mill processes the ore from the Cigar Lake mine, the world's second largest and highest-grade uranium mine. The McClean Lake site operates 365 days a year on a week-in/week-out rotation schedule for workers, over 50% of whom reside in northern Saskatchewan communities. Tailings are waste products resulting from milling uranium ore. This waste is made up of leach residue solids, waste solutions and chemical precipitates that are carefully engineered for long-term disposal. The TMF serves as the repository for all resulting tailings. This facility allows proper waste management, which minimizes potential adverse environmental effects. Mining projections indicate that the McClean Lake mill will produce tailings in excess of the existing capacity of the TMF. After evaluating a number of options, Areva has decided to pursue an expansion of this facility. Areva is developing the Surface Access Borehole Resource Extraction (SABRE) mining method, which uses a high-pressure water jet placed at the bottom of the drill hole to extract ore. Areva has conducted a series of tests with this method and is evaluating its potential for future mining operations. McClean Lake maintains its certification in ISO 14001 standards for environmental management and OHSAS 18001 standards for occupational health

  9. CloudMC: a cloud computing application for Monte Carlo simulation

    International Nuclear Information System (INIS)

    Miras, H; Jiménez, R; Miras, C; Gomà, C

    2013-01-01

    This work presents CloudMC, a cloud computing application—developed in Windows Azure®, the platform of the Microsoft® cloud—for the parallelization of Monte Carlo simulations in a dynamic virtual cluster. CloudMC is a web application designed to be independent of the Monte Carlo code in which the simulations are based—the simulations just need to be of the form: input files → executable → output files. To study the performance of CloudMC in Windows Azure®, Monte Carlo simulations with penelope were performed on different instance (virtual machine) sizes, and for different number of instances. The instance size was found to have no effect on the simulation runtime. It was also found that the decrease in time with the number of instances followed Amdahl's law, with a slight deviation due to the increase in the fraction of non-parallelizable time with increasing number of instances. A simulation that would have required 30 h of CPU on a single instance was completed in 48.6 min when executed on 64 instances in parallel (speedup of 37 ×). Furthermore, the use of cloud computing for parallel computing offers some advantages over conventional clusters: high accessibility, scalability and pay per usage. Therefore, it is strongly believed that cloud computing will play an important role in making Monte Carlo dose calculation a reality in future clinical practice. (note)

  10. CloudMC: a cloud computing application for Monte Carlo simulation.

    Science.gov (United States)

    Miras, H; Jiménez, R; Miras, C; Gomà, C

    2013-04-21

    This work presents CloudMC, a cloud computing application-developed in Windows Azure®, the platform of the Microsoft® cloud-for the parallelization of Monte Carlo simulations in a dynamic virtual cluster. CloudMC is a web application designed to be independent of the Monte Carlo code in which the simulations are based-the simulations just need to be of the form: input files → executable → output files. To study the performance of CloudMC in Windows Azure®, Monte Carlo simulations with penelope were performed on different instance (virtual machine) sizes, and for different number of instances. The instance size was found to have no effect on the simulation runtime. It was also found that the decrease in time with the number of instances followed Amdahl's law, with a slight deviation due to the increase in the fraction of non-parallelizable time with increasing number of instances. A simulation that would have required 30 h of CPU on a single instance was completed in 48.6 min when executed on 64 instances in parallel (speedup of 37 ×). Furthermore, the use of cloud computing for parallel computing offers some advantages over conventional clusters: high accessibility, scalability and pay per usage. Therefore, it is strongly believed that cloud computing will play an important role in making Monte Carlo dose calculation a reality in future clinical practice.

  11. Use of the McQuarrie equation for the computation of shear viscosity via equilibrium molecular dynamics

    International Nuclear Information System (INIS)

    Chialvo, A.A.; Debenedetti, P.G.

    1991-01-01

    To date, the calculation of shear viscosity for soft-core fluids via equilibrium molecular dynamics has been done almost exclusively using the Green-Kubo formalism. The alternative mean-squared displacement approach has not been used, except for hard-sphere fluids, in which case the expression proposed by Helfand [Phys. Rev. 119, 1 (1960)] has invariably been selected. When written in the form given by McQuarrie [Statistical Mechanics (Harper ampersand Row, New York, 1976), Chap. 21], however, the mean-squared displacement approach offers significant computational advantages over both its Green-Kubo and Helfand counterparts. In order to achieve comparable statistical significance, the number of experiments needed when using the Green-Kubo or Helfand formalisms is more than an order of magnitude higher than for the McQuarrie expression. For pairwise-additive systems with zero linear momentum, the McQuarrie method yields frame-independent shear viscosities. The hitherto unexplored McQuarrie implementation of the mean-squared displacement approach to shear-viscosity calculation thus appears superior to alternative methods currently in use

  12. Genetics Home Reference: McLeod neuroacanthocytosis syndrome

    Science.gov (United States)

    ... Castiglioni C, Oechsner M, Goebel HH, Heppner FL, Jung HH. McLeod myopathy revisited: more neurogenic and less ... 130(Pt 12):3285-96. Citation on PubMed Jung HH, Danek A, Frey BM. McLeod syndrome: a ...

  13. Something black in the American Psyche: formal innovation and Freudian imagery in the comics of Winsor McCay and Robert Crumb.

    Science.gov (United States)

    Shannon, Edward A

    2010-01-01

    Winsor McCay’s Little Nemo in Slumberland anticipates Robert Crumb’s work. McCay’s innocent dreamscapes seem antithetical to the sexually explicit work of anti-capitalist Crumb, but Nemo looks forward to Crumb in subject and form. Nemo’s presentation of class, gender, and race, and its pre-Freudian sensibility are ironic counterpoints to Crumb’s political, Freudian comix.

  14. McDonaldization and Job Insecurity

    Directory of Open Access Journals (Sweden)

    Emeka W. Dumbili

    2013-06-01

    Full Text Available The article examines how and why the McDonaldization of banking system in Nigeria engenders job insecurity. This is imperative because it provides an explicit revelation of the root causes of job insecurity in the sector that other scholars have totally omitted. No Nigerian scholar has applied the thesis in relation to job insecurity, which is the major problem in Nigeria’s banking industry. The article based on the analysis of secondary data and observations, therefore, draws on McDonaldization thesis to examine the upsurge of rationalization in the sector since consolidation exercise began in 2005. The article argues that the sector’s rising rationalization and ensuing efficiency, calculability, predictability, and control are necessary. However, these have inevitably engendered job insecurity and its adverse consequences. Based on the critical analyses of available evidence, the article concludes that the best option is to commence resistance of the McDonaldization processes, especially those that replace human with nonhuman technology or make customers unpaid workers.

  15. Henry P. McKean Jr. selecta

    CERN Document Server

    Moerbeke, Pierre; Moll, Victor

    2015-01-01

    This volume presents a selection of papers by Henry P. McKean, which illustrate the various areas in mathematics in which he has made seminal contributions. Topics covered include probability theory, integrable systems, geometry and financial mathematics. Each paper represents a contribution by Prof. McKean, either alone or together with other researchers, that has had a profound influence in the respective area.

  16. Geophysical expression of caldera related volcanism, structures and mineralization in the McDermitt volcanic field

    Science.gov (United States)

    Rytuba, J. J.; Blakely, R. J.; Moring, B.; Miller, R.

    2013-12-01

    The High Rock, Lake Owyhee, and McDermitt volcanic fields, consisting of regionally extensive ash flow tuffs and associated calderas, developed in NW Nevada and SE Oregon following eruption of the ca. 16.7 Ma Steens flood basalt. The first ash flow, the Tuff of Oregon Canyon, erupted from the McDermitt volcanic field at 16.5Ma. It is chemically zoned from peralkaline rhyolite to dacite with trace element ratios that distinguish it from other ash flow tuffs. The source caldera, based on tuff distribution, thickness, and size of lithic fragments, is in the area in which the McDermitt caldera (16.3 Ma) subsequently formed. Gravity and magnetic anomalies are associated with some but not all of the calderas. The White Horse caldera (15.6 Ma), the youngest caldera in the McDermitt volcanic field has the best geophysical expression, with both aeromagnetic and gravity lows coinciding with the caldera. Detailed aeromagnetic and gravity surveys of the McDermitt caldera, combined with geology and radiometric surveys, provides insight into the complexities of caldera collapse, resurgence, post collapse volcanism, and hydrothermal mineralization. The McDermitt caldera is among the most mineralized calderas in the world, whereas other calderas in these three Mid Miocene volcanic fields do not contain important hydrothermal ore deposits, despite having similar age and chemistry. The McDermitt caldera is host to Hg, U, and Li deposits and potentially significant resources of Ga, Sb, and REE. The geophysical data indicate that post-caldera collapse intrusions were important in formation of the hydrothermal systems. An aeromagnetic low along the E caldera margin reflects an intrusion at a depth of 2 km associated with the near-surface McDermitt-hot-spring-type Hg-Sb deposit, and the deeper level, high-sulfidation Ga-REE occurrence. The Li deposits on the W side of the caldera are associated with a series of low amplitude, small diameter aeromagnetic anomalies that form a continuous

  17. The OpenMC Monte Carlo particle transport code

    International Nuclear Information System (INIS)

    Romano, Paul K.; Forget, Benoit

    2013-01-01

    Highlights: ► An open source Monte Carlo particle transport code, OpenMC, has been developed. ► Solid geometry and continuous-energy physics allow high-fidelity simulations. ► Development has focused on high performance and modern I/O techniques. ► OpenMC is capable of scaling up to hundreds of thousands of processors. ► Results on a variety of benchmark problems agree with MCNP5. -- Abstract: A new Monte Carlo code called OpenMC is currently under development at the Massachusetts Institute of Technology as a tool for simulation on high-performance computing platforms. Given that many legacy codes do not scale well on existing and future parallel computer architectures, OpenMC has been developed from scratch with a focus on high performance scalable algorithms as well as modern software design practices. The present work describes the methods used in the OpenMC code and demonstrates the performance and accuracy of the code on a variety of problems.

  18. NTS MC and A History

    International Nuclear Information System (INIS)

    Mary Alice Price; Kim Young

    2008-01-01

    Within the past three and a half years, the Nevada Test Site (NTS) has progressed from a Category IV to a Category I nuclear material facility. In accordance with direction from the U.S. Department of Energy (DOE) Secretary and National Nuclear Security Administration (NNSA) Administrator, NTS received shipments of large quantities of special nuclear material from Los Alamos National Laboratory (LANL) and other sites in the DOE complex. December 2004 was the first occurrence of Category I material at the NTS, with the exception of two weeks of sub-critical underground testing in 2001, since 1992. The Material Control and Accountability (MC and A) program was originally a jointlab effort by LANL, Lawrence Livermore National Laboratory, and Bechtel Nevada, but in March 2006 the NNSA Nevada Site Office appointed the NTS Management and Operations contractor with sole responsibility. This paper will discuss the process and steps taken to transition the NTS MC and A program from multiple organizations to a single entity and from a Category IV to a Category I program. This transition flourished as MC and A progressed from the 2004 Office of Assessment (OA) rating of 'Significant Weakness' to the 2007 OA assessment rating of 'Effective Performance'. The paper will provide timelines, funding and staffing issues, OA assessment findings and corrective actions, and future expectations. The process has been challenging, but MC and A's innovative responses to the challenges have been very successful

  19. Bit Error Rate Analysis for MC-CDMA Systems in Nakagami- Fading Channels

    Directory of Open Access Journals (Sweden)

    Li Zexian

    2004-01-01

    Full Text Available Multicarrier code division multiple access (MC-CDMA is a promising technique that combines orthogonal frequency division multiplexing (OFDM with CDMA. In this paper, based on an alternative expression for the -function, characteristic function and Gaussian approximation, we present a new practical technique for determining the bit error rate (BER of multiuser MC-CDMA systems in frequency-selective Nakagami- fading channels. The results are applicable to systems employing coherent demodulation with maximal ratio combining (MRC or equal gain combining (EGC. The analysis assumes that different subcarriers experience independent fading channels, which are not necessarily identically distributed. The final average BER is expressed in the form of a single finite range integral and an integrand composed of tabulated functions which can be easily computed numerically. The accuracy of the proposed approach is demonstrated with computer simulations.

  20. Techno-Orientalism with Chinese Characteristics: Maureen F. McHugh’s China Mountain Zhang

    Directory of Open Access Journals (Sweden)

    Christopher T. Fan

    2015-03-01

    Full Text Available Christopher T. Fan argues that McHugh’s award-winning 1992 science fiction novel perceives the twilight of the American Century by offering a “critical realism,” to use Georg Lukács’s phrase, of postsocialist US–China interdependency. In other words, it offers a form in which we perceive ourselves as subjects and objects of the twenty-first century world-system’s most important bilateral relationship. Moreover, as a novel about US–China interdependency, it implicitly critiques the binary Orientalism that structures the rapidly growing body of work on “techno-Orientalist” formations. Fan's analysis thus extends arguments about American Orientalism’s non-Manichean formations (Christina Klein, Melani McAlister, Colleen Lye into the postsocialist era.The novel’s near-future, China-centric world analogizes McHugh’s personal crises of professional desire as a precarious laborer in New York City, with the massive reorientation of desires from Maoist politics to market-directed individuality that she witnessed among her students when she taught in China from 1987–1988. Chinese racial form plays a crucial mediating role in the novel because it reflects the revival of Confucian humanist discourse in reform-era China as a way to focus a national project of rapidly generating capitalist desire. Finally, by describing US–China interdependency, this article also generates a theory of US–China neoliberalism that corrects for universalist, Euro-American accounts of neoliberal subject formation (Lauren Berlant, as well as insufficiently subject-sensitive accounts (Aihwa Ong.

  1. Manual del McVCO 1999

    Science.gov (United States)

    McChesney, P.J.

    1999-01-01

    El McVCO es un generador de frecuencias basado en un microcontrolador que reemplaza al oscilador controlado por voltaje (VCO) utilizado en telemetría analógica de datos sísmicas. Acepta señales de baja potencia desde un sismómetro y produce una señal subportadora modulada en frecuencia adecuada para enlaces telefónicos o vía radio a un lugar remoto de recolección de datos. La frecuencia de la subportadora y la ganancia pueden ser seleccionadas mediante un interruptor. Tiene la opción de poder operar con dos canales para la observación con ganancia alta y baja. El McVCO fue diseñado con el propósito de mejorar la telemetría analógica de las señales dentro de la Pacific Northwest Seismograph Network (PNSN) (Red Sismográfica del Noroeste del Pacífico). Su desarrollo recibió el respaldo del Programa de Geofísica de la Universidad de Washington y del "Volcano Hazards and Earthquake Hazards programs of the United States Geological Survey (USGS) (Programa de Investigaciones de Riesgos Volcánicos y Programa de Investigaciones de Riesgos Sísmicos de los EEUU). Cientos de instrumentos se han construido e instalado. Además de utilizarlo el PNSN, el McVCO es usado por el Observatorio Vulcanológico de Alaska para monitorear los volcanes aleutianos y por el USGS Volcano Disaster Assistance Program (Programa de Ayuda en las Catástrofes Volcánicas del USGS) para responder a crisis volcánicas en otros países. Este manual cubre el funcionamiento del McVCO, es una referencia técnica para aquellos que necesitan saber con más detalle cómo funciona el McVCO, y cubre una serie de temas que requieren un trato explícito o que derivan del despliegue del instrumento.

  2. J.B. McLachlan: a biography

    Energy Technology Data Exchange (ETDEWEB)

    Frank, D.

    1999-07-01

    This social history and biography of James Bryson McLaughlin (1869-1916) describes McLaughlin's leadership as an educator and instigator in organizing Nova Scotia's coal miners during the labour wars in the 1920s. McLaughlin's background and childhood, education, reputation, religion, family life, health, and death are described. Included are descriptions of the life of coal miners in Cape Breton, radical left politics in Canada and the organizers involved, the political economy of the coal industry, child labour, churches, coal markets and prices, company towns and housing, mining disasters and fatalities, elections, First World War efforts, the depression, immigrants, and strikes. The labour organizations, companies, churches, and politicians involved in the struggles for union acceptance are discussed. 872 refs., 7 figs., 24 photos.

  3. Perhydropolysilazane-derived silica-polymethylmethacrylate hybrid thin films highly doped with spiropyran: Effects of polymethylmethacrylate on the hardness, chemical durability and photochromic properties

    International Nuclear Information System (INIS)

    Yamano, Akihiro; Kozuka, Hiromitsu

    2011-01-01

    Polymethylmethacrylate (PMMA)-perhydropolysilazane (PHPS) hybrid thin films doped with spiropyran were prepared by spin-coating, which were then converted into 0.26-1.7 μm thick, spiropyran-doped PMMA-silica hybrid films by exposure treatment over aqueous ammonia. The spiropyran/(spiropyran + PHPS + PMMA) mass ratio was fixed at a high value of 0.2 so that the films exhibit visual photochromic changes in color, while the PMMA/(PMMA + PHPS) mass ratio, r, was varied. The spiropyran molecules in the as-prepared films were in merocyanine (MC) and spiro (SP) forms, with and without an optical absorption at 500 nm, at low (r ≤ 0.2) and high (r ≥ 0.4) PMMA contents, respectively. When PMMA content r was increased from 0 to 0.2, the degree of the MC-to-SP conversion on vis light illumination was enhanced, while at higher r's the spiropyran molecules underwent photodegradation. When the silica film (r = 0) was soaked in xylene under vis light, the spiropyran molecules were almost totally leached out, while not on soaking in the dark. On the other hand, no leaching occurred for the film of r = 0.2 either in the presence or absence of vis light. These suggest that the introduction of PMMA is effective in improving the chemical durability of the films, while the silica film (r = 0) is an interesting material with a photoresponsive controlled-release ability. The pencil hardness of the films decreased with increasing PMMA content, but remained over 9H at r ≤ 0.4.

  4. Application of quality assurance to MC and A systems

    International Nuclear Information System (INIS)

    Skinner, A.J.; Delvin, W.L.

    1986-01-01

    Application of the principles of quality assurance to MC and A has been done at DOE's Savannah River Operations Office. The principles were applied to the functions within the MC and A Branch, including both the functions used to operate the Branch and those used to review the MC and A activities of DOE/SR's contractor. The purpose of this paper is to discuss that application of quality assurance and to show how the principles of quality assurance relate to the functions of a MC and A system, for both a DOE field office and a contractor. The principles (presented as requirements from the NQA-1 standard) are briefly discussed, a method for applying quality assurance is outlined, application at DOE/SR is shown, and application to a contractor's MC and A system is discussed

  5. Modeling of the energy savings of variable recruitment McKibben muscle bundles

    Science.gov (United States)

    Meller, Michael A.; Chipka, Jordan B.; Bryant, Matthew J.; Garcia, Ephrahim

    2015-03-01

    McKibben artificial muscles are often utilized in mobile robotic applications that require compliant and light weight actuation capable of producing large forces. In order to increase the endurance of these mobile robotic platforms, actuation efficiency must be addressed. Since pneumatic systems are rarely more than 30% efficient due to the compressibility of the working fluid, the McKibben muscles are hydraulically powered. Additionally, these McKibben artificial muscles utilize an inelastic bladder to reduce the energy losses associated with elastic energy storage in the usual rubber tube bladders. The largest energy losses in traditional valve-controlled hydraulic systems are found in the valving implementation to match the required loads. This is performed by throttling, which results in large pressure drops over the control valves and significant fluid power being wasted as heat. This paper discusses how these throttling losses are reduced by grouping multiple artificial muscles to form a muscle bundle where, like in skeletal muscle, more elements that make up the muscle bundle are recruited to match the load. This greatly lessens the pressure drops by effectively changing the actuator area, leading to much higher efficiencies over a broader operation envelope. Simulations of several different loading scenarios are discussed that reveal the benefits of such an actuation scheme.

  6. Fast Food McDonald's China Fix

    Institute of Scientific and Technical Information of China (English)

    DAVID HENDRICKSON

    2006-01-01

    @@ Since the opening of its first outlet 16 years ago, McDonald's China operation has on many levels proven enormously successful.Home to more than 750 locations nationwide, the Middle Kingdom today ranks as one of McDonald's ten largest markets,with returns hovering in doubles digits and raking in billions annually. As lucrative as it may be, however, China has nonetheless developed into a relative sore spot for the world's leading fast food giant.

  7. Eschatologisch-Soteriologische Aspekte in Cormac McCarthy’s Roman: „The Road/Die Straße“

    Directory of Open Access Journals (Sweden)

    Peter Blomen

    2012-06-01

    Full Text Available Abstract to: Eschatological and Soteriological Aspects in Cormac McCarthy’s Novel „The Road“ - My deliberations emanate from the fact that McCarthy’s “The Road” was praised by the critics as the “book nearest approaching the Old Testament in the history of literature”. In the first instance, in this essay, consideration was given as to the philosophical-metaphysical foundations of this work of McCarthy’s as a whole. Moreover, connections with the Ontology of Martin Heidegger were established and, in particular, consideration with regard to his understanding of Humanity. These philosophical ways of thinking were, very briefly, applied to an early work of McCarthy’s, “Outer Dark”.In the main part of the deliberations I focus on the aspects and elements of the Judeo-Christian traditions which can be detected, in quantitatively large numbers, in McCarthy’s novel “The Road”. Nevertheless, these traditions found their way into world literature to which McCarthy refers directly or indirectly. A large part ofmy text analysis is devoted to the hidden parts of the eschatological-soteriological literature, as they appearagain in the novel “The Road”.Decisive, however, is that the loan which McCarthy takes in hand from the eschatological-soteriological characterised literary tradition, not only in a hyperbolical manner for his own literary purposes rather over and above the apocalypse of our time and the therefrom emerging redemption in the form of the Father-Son-Relationship, which is commemorated over and beyond death. McCarthy’s most important message exists not merely therein that the human race itself – deservedly – prepares its own end, rather the by far happier hopeful message that the book conveys, is the most important assertion of belief that St. Paul in the first Letter to the Corinthians undertakes: That the world, from pain, sorrow and ashes, may rise again in beauty and grace – presupposing we have not

  8. Inhibition of serotonin transport by (+)McN5652 is noncompetitive

    Energy Technology Data Exchange (ETDEWEB)

    Hummerich, Rene [Biochemical Laboratory, Central Institute of Mental Health, 68159 Mannheim (Germany); Schulze, Oliver [Department of Nuclear Medicine, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg (Germany); Raedler, Thomas [Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg (Germany); Mikecz, Pal [Department of Nuclear Medicine, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg (Germany); Reimold, Matthias [Department of Nuclear Medicine, University Hospital Tuebingen, D-72076 Tuebingen (Germany); Brenner, Winfried [Department of Nuclear Medicine, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg (Germany); Clausen, Malte [Department of Nuclear Medicine, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg (Germany); Schloss, Patrick [Biochemical Laboratory, Central Institute of Mental Health, 68159 Mannheim (Germany); Buchert, Ralph [Department of Nuclear Medicine, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg (Germany)]. E-mail: buchert@uke.uni-hamburg.de

    2006-04-15

    Introduction: Imaging of the serotonergic innervation of the brain using positron emission tomography (PET) with the serotonin transporter (SERT) ligand [{sup 11C}] (+)McN5652 might be affected by serotonin in the synaptic cleft if there is relevant interaction between [{sup 11}C] (+)McN5652 and serotonin at the SERT. The aim of the present study therefore was to pharmacologically characterize the interaction of [{sup 11}C] (+)McN5652 and serotonin at the SERT. Methods: In vitro saturation analyses of [{sup 3}H]serotonin uptake into HEK293 cells stably expressing the human SERT were performed in the absence and presence of unlabelled (+)McN5652. Data were evaluated assuming Michaelis-Menten kinetics. Results: Unlabelled (+)McN5652 significantly reduced the maximal rate of serotonin transport V {sub max} of SERT without affecting the Michaelis-Menten constant K {sub M}. Conclusions: This finding indicates that (+)McN5652 inhibits serotonin transport through the SERT in a noncompetitive manner. This might suggest that [{sup 11}C] (+)McN5652 PET is not significantly affected by endogenous serotonin.

  9. Inhibition of serotonin transport by (+)McN5652 is noncompetitive

    International Nuclear Information System (INIS)

    Hummerich, Rene; Schulze, Oliver; Raedler, Thomas; Mikecz, Pal; Reimold, Matthias; Brenner, Winfried; Clausen, Malte; Schloss, Patrick; Buchert, Ralph

    2006-01-01

    Introduction: Imaging of the serotonergic innervation of the brain using positron emission tomography (PET) with the serotonin transporter (SERT) ligand [ 11C ] (+)McN5652 might be affected by serotonin in the synaptic cleft if there is relevant interaction between [ 11 C] (+)McN5652 and serotonin at the SERT. The aim of the present study therefore was to pharmacologically characterize the interaction of [ 11 C] (+)McN5652 and serotonin at the SERT. Methods: In vitro saturation analyses of [ 3 H]serotonin uptake into HEK293 cells stably expressing the human SERT were performed in the absence and presence of unlabelled (+)McN5652. Data were evaluated assuming Michaelis-Menten kinetics. Results: Unlabelled (+)McN5652 significantly reduced the maximal rate of serotonin transport V max of SERT without affecting the Michaelis-Menten constant K M . Conclusions: This finding indicates that (+)McN5652 inhibits serotonin transport through the SERT in a noncompetitive manner. This might suggest that [ 11 C] (+)McN5652 PET is not significantly affected by endogenous serotonin

  10. Official portrait of Astronaut Ronald E. McNair

    Science.gov (United States)

    1985-01-01

    Official portrait of Astronaut Ronald E. McNair. McNair is in the blue shuttle flight suit, standing in front of a table which holds a model of the Space Shuttle. An American flag is visible behind him.

  11. An ordinal model of the McGurk illusion

    DEFF Research Database (Denmark)

    Andersen, Tobias

    2011-01-01

    Audiovisual information is integrated in speech perception. One manifestation of this is the McGurk illusion in which watching the articulating face alters the auditory phonetic percept. Understanding this phenomenon fully requires a computational model with predictive power. Here, we describe...... model it also employed 30 free parameters where the ordinal model needed only 14. Testing the predictive power of the models using a form of cross-validation we found that, although both models performed rather poorly, the ordinal model performed better than the FLMP. Based on these findings we suggest...... that ordinal models generally have greater predictive power because they are constrained by a priori information about the adjacency of phonetic categories....

  12. Epilepsy and McArdle Disease in A Child

    Directory of Open Access Journals (Sweden)

    Faruk incecik

    2015-03-01

    Full Text Available McArdle's disease, defined by the lack of functional glycogen phosphorylase in striated muscle, is inherited as an autosomal recessive trait. Patients typically suffer from reduced exercise tolerance, with muscle cramps and pain provoked by exercise, along with easy fatigability and weakness after exercise. Following prolonged exertion, contractures, rhabdomyolysis, and myoglobinuria may occur. Central nervous system symptoms have rarely been reported in McArdle disease. In this case report, a 13-year-old boy with epilepsy and McArdle's disease is presented. [Cukurova Med J 2015; 40(Suppl 1: 5-7

  13. Incomplete McCune-Albright Syndrome: A Case Report

    Directory of Open Access Journals (Sweden)

    Nagehan Aslan

    2014-08-01

    Full Text Available Fibrous dysplasia of bone is a genetic, non-inheritable disease that can cause bone pain, bone deformities and fracture. It has a large clinic spectrum from benign monostotic fibrous dysplasia to McCune-Albright syndrome. Rare McCune-Albright syndrome is characterized by precocious puberty, cafe au lait spots and fibrous dysplasia. Herein we presented a case who was preferred to hospital with pathological fractures and diagnosed with Incomplet McCune Albright syndrome because of the lack of endocrine hyperfunction and developed early puberty at clinical course.

  14. McJobs and Pieces of Flair: Linking McDonaldization to Alienating Work

    Science.gov (United States)

    Treiber, Linda Ann

    2013-01-01

    This article offers strategies for teaching about rationality, bureaucracy, and social change using George Ritzer's "The McDonaldization of Society" and its ideas about efficiency, predictability, calculability, and control. Student learning is facilitated using a series of strategies: making the familiar strange, explaining…

  15. Melanocortin MC(4) receptor-mediated feeding and grooming in rodents.

    Science.gov (United States)

    Mul, Joram D; Spruijt, Berry M; Brakkee, Jan H; Adan, Roger A H

    2013-11-05

    Decades ago it was recognized that the pharmacological profile of melanocortin ligands that stimulated grooming behavior in rats was strikingly similar to that of Xenopus laevis melanophore pigment dispersion. After cloning of the melanocortin MC1 receptor, expressed in melanocytes, and the melanocortin MC4 receptor, expressed mainly in brain, the pharmacological profiles of these receptors appeared to be very similar and it was demonstrated that these receptors mediate melanocortin-induced pigmentation and grooming respectively. Grooming is a low priority behavior that is concerned with care of body surface. Activation of central melanocortin MC4 receptors is also associated with meal termination, and continued postprandial stimulation of melanocortin MC4 receptors may stimulate natural postprandial grooming behavior as part of the behavioral satiety sequence. Indeed, melanocortins fail to suppress food intake or induce grooming behavior in melanocortin MC4 receptor-deficient rats. This review will focus on how melanocortins affect grooming behavior through the melanocortin MC4 receptor, and how melanocortin MC4 receptors mediate feeding behavior. This review also illustrates how melanocortins were the most likely candidates to mediate grooming and feeding based on the natural behaviors they induced. Copyright © 2013 Elsevier B.V. All rights reserved.

  16. NNLO QCD corrections to the $B\\to X_s \\gamma$ matrix elements using interpolation in $m_c$

    CERN Document Server

    Misiak, M; Misiak, Mikolaj; Steinhauser, Matthias

    2007-01-01

    One of the most troublesome contributions to the NNLO QCD corrections to B -> X_s gamma originates from three-loop matrix elements of four-quark operators. A part of this contribution that is proportional to the QCD beta-function coefficient beta_0 was found in 2003 as an expansion in m_c/m_b. In the present paper, we evaluate the asymptotic behaviour of the complete contribution for m_c >> m_b/2. The asymptotic form of the beta_0-part matches the small-m_c expansion very well at the threshold m_c = m_b/2. For the remaining part, we perform an interpolation down to the measured value of m_c, assuming that the beta_0-part is a good approximation at m_c=0. Combining our results with other contributions to the NNLO QCD corrections, we find BR(B -> X_s gamma) = (3.15 +_ 0.23) x 10^-4 for E_gamma > 1.6 GeV in the B-meson rest frame. The indicated error has been obtained by adding in quadrature the following uncertainties: non-perturbative (5%), parametric (3%), higher-order perturbative (3%), and the interpolation...

  17. Improving queuing service at McDonald's

    Science.gov (United States)

    Koh, Hock Lye; Teh, Su Yean; Wong, Chin Keat; Lim, Hooi Kie; Migin, Melissa W.

    2014-07-01

    Fast food restaurants are popular among price-sensitive youths and working adults who value the conducive environment and convenient services. McDonald's chains of restaurants promote their sales during lunch hours by offering package meals which are perceived to be inexpensive. These promotional lunch meals attract good response, resulting in occasional long queues and inconvenient waiting times. A study is conducted to monitor the distribution of waiting time, queue length, customer arrival and departure patterns at a McDonald's restaurant located in Kuala Lumpur. A customer survey is conducted to gauge customers' satisfaction regarding waiting time and queue length. An android app named Que is developed to perform onsite queuing analysis and report key performance indices. The queuing theory in Que is based upon the concept of Poisson distribution. In this paper, Que is utilized to perform queuing analysis at this McDonald's restaurant with the aim of improving customer service, with particular reference to reducing queuing time and shortening queue length. Some results will be presented.

  18. The Travails of Criticality: Understanding Peter McLaren's Revolutionary Vocation. An Article Review of Peter McLaren, "Pedagogy of Insurrection" (New York: Peter Lang, 2015)

    Science.gov (United States)

    Baldacchino, John

    2017-01-01

    This is an article review of Peter McLaren's "Pedagogy of Insurrection" (New York: Peter Lang, 2015). While it seeks to position McLaren's work within the context of critical pedagogy, this paper also assesses McLaren from the wider discussion of Marxist--Hegelian discourse as it evolved within the Left. Engaging with McLaren critically,…

  19. Purification and characterization of enterocin MC13 produced by a potential aquaculture probiont Enterococcus faecium MC13 isolated from the gut of Mugil cephalus.

    Science.gov (United States)

    Satish Kumar, R; Kanmani, P; Yuvaraj, N; Paari, K A; Pattukumar, V; Arul, V

    2011-12-01

    A bacteriocin producer strain MC13 was isolated from the gut of Mugil cephalus (grey mullet) and identified as Enterococcus faecium. The bacteriocin of E. faecium MC13 was purified to homogeneity, as confirmed by Tricine sodium dodecyl sulphate - polyacrylamide gel electrophoresis (SDS-PAGE). Reverse-phase high-performance liquid chromatography (HPLC) analysis showed a single active fraction eluted at 26 min, and matrix-assisted laser desorption ionization time of flight (MALDI-TOF) mass spectrometry analysis showed the molecular mass to be 2.148 kDa. The clear zone in native PAGE corresponding to enterocin MC13 band further substantiated its molecular mass. A dialyzed sample (semicrude preparation) of enterocin MC13 was broad spectrum in its action and inhibited important seafood-borne pathogens: Listeria monocytogenes , Vibrio parahaemolyticus, and Vibrio vulnificus. This antibacterial substance was sensitive to proteolytic enzymes: trypsin, protease, and chymotrypsin but insensitive to catalase and lipase, confirming that inhibition was due to the proteinaceous molecule, i.e., bacteriocin, and not due to hydrogen peroxide. Enterocin MC13 tolerated heat treatment (up to 90 °C for 20 min). Enterococcus faecium MC13 was effective in bile salt tolerance, acid tolerance, and adhesion to the HT-29 cell line. These properties reveal the potential of E. faecium MC13 to be a probiotic bacterium. Enterococcus faecium MC13 could be used as potential fish probiotic against pathogens such as V. parahaemolyticus, Vibrio harveyi, and Aeromonas hydrophila in fisheries. Also, this could be a valuable seafood biopreservative against L. monocytogenes.

  20. The Einstein formula: E0=mc2. 'Isn't the Lord laughing?'

    International Nuclear Information System (INIS)

    Okun, L B

    2008-01-01

    The article traces the way Einstein formulated the relation between energy and mass in his work from 1905 to 1955. Einstein emphasized quite often that the mass m of a body is equivalent to its rest energy E 0 . At the same time, he frequently resorted to the less clear-cut statement of the equivalence of energy and mass. As a result, Einstein's formula E 0 =mc 2 still remains much less known than its popular form, E=mc 2 , in which E is the total energy equal to the sum of the rest energy and the kinetic energy of a freely moving body. One of the consequences of this is the widespread fallacy that the mass of a body increases when its velocity increases and even that this is an experimental fact. As wrote the playwright A N Ostrovsky 'Something must exist for people, something so austere, so lofty, so sacrosanct that it would make profaning it unthinkable.' (from the history of physics)

  1. Multiple bodies in the spirituality of the gay porn star McCree: reflections on corporeality and subjectivity

    Directory of Open Access Journals (Sweden)

    Peter Nynäs

    2011-01-01

    Full Text Available Body modification practices have lately gained growing visibility in contemporary Western cultures. It is more like a trend or fashion ranging from, on the on hand, decorative tattoos and piercing, to branding, implants and surgery on the other. In most forms body modification occurs without any obvious religious, spiritual or ideological marks attached, but some forms involve discourses that explicitly address such aspirations. However, despite the fluidity and diversity of practices, it can be claimed that body modification represents specific or distinct ways of working with the body that differ from other forms of contemporary Western body cultures. Further, it needs be considered as part of the broader body culture. Hence it draws our attention to the role of corporeality in contemporary Western culture. Body modification could be regarded as a reaction to the nature of contemporary society, a way of compensating the lack of corporeal engagement in the world. Its former association with different subcultures might underpin this oppositional position. On the other hand, some scholars regard body-modification as nothing but part of the contemporary free floating carnival of signs, as mere mainstream supermarket signifiers, emptied of meaning and deprived of any external references. In this article emphasis is put on forms of body modification that more explicitly connote religion. One example of body modification is explored from an empirical perspective: the story about the spirituality of the gay porn star Logan McCree. This is a personal narrative about spirituality in which tattooing plays a central role. Still, despite being personal it is also part of McCree’s public image. With the help of both literature and the examples on body modification the place of corporeality in the story of McCree is explored. The aim is to shed some light on corporeality and in particular in relation to subjectivity.

  2. Potential effects of the next 100 billion hamburgers sold by McDonald's.

    Science.gov (United States)

    Spencer, Elsa H; Frank, Erica; McIntosh, Nichole F

    2005-05-01

    McDonald's has sold >100 billion beef-based hamburgers worldwide with a potentially considerable health impact. This paper explores whether there would be any advantages if the next 100 billion burgers were instead plant-based burgers. Nutrient composition of the beef hamburger patty and the McVeggie burger patty were obtained from the McDonald's website; sales data were obtained from the McDonald's customer service. Consuming 100 billion McDonald's beef burgers versus the same company's McVeggie burgers would provide, approximately, on average, an additional 550 million pounds of saturated fat and 1.2 billion total pounds of fat, as well as 1 billion fewer pounds of fiber, 660 million fewer pounds of protein, and no difference in calories. These data suggest that the McDonald's new McVeggie burger represents a less harmful fast-food choice than the beef burger.

  3. MC Sensor—A Novel Method for Measurement of Muscle Tension

    Directory of Open Access Journals (Sweden)

    Sašo Tomažič

    2011-09-01

    Full Text Available This paper presents a new muscle contraction (MC sensor. This MC sensor is based on a novel principle whereby muscle tension is measured during muscle contractions. During the measurement, the sensor is fixed on the skin surface above the muscle, while the sensor tip applies pressure and causes an indentation of the skin and intermediate layer directly above the muscle and muscle itself. The force on the sensor tip is then measured. This force is roughly proportional to the tension of the muscle. The measurement is non-invasive and selective. Selectivity of MC measurement refers to the specific muscle or part of the muscle that is being measured and is limited by the size of the sensor tip. The sensor is relatively small and light so that the measurements can be performed while the measured subject performs different activities. Test measurements with this MC sensor on the biceps brachii muscle under isometric conditions (elbow angle 90° showed a high individual linear correlation between the isometric force and MC signal amplitudes (0.97 ≤ r ≤ 1. The measurements also revealed a strong correlation between the MC and electromyogram (EMG signals as well as good dynamic behaviour by the MC sensor. We believe that this MC sensor, when fully tested, will be a useful device for muscle mechanic diagnostics and that it will be complementary to existing methods.

  4. Thermal behavior of H-aggregate in a mixed Langmuir-Blodgett film of merocyanine dye, arachidic acid, and n-octadecane ternary system investigated by UV-visible and IR absorption spectroscopy.

    Science.gov (United States)

    Hirano, Yoshiaki; Tateno, Shinsuke; Yamashita, Yoshihide; Ozaki, Yukihiro

    2008-11-13

    We have investigated the thermal behavior of H-aggregate in a mixed Langmuir-Blodgett (LB) film of the merocyanine dye (MS18)-arachidic acid (C20)- n-octadecane (AL18) ternary system by means of UV-visible and IR absorption spectroscopy in the range from 25 to 250 degrees C with a continuous scan. The results of both UV-visible and IR spectra indicate that the temperature-dependent variation in MS 18 aggregation state is linked not only with the degree of intramolecular charge transfer and the behavior of packing, orientation, conformation, and thermal mobility of the MS18 hydrocarbon chain but also with the presence and absence of AL18. The H-aggregate dissociates from 25 up to 50 degrees C, which is caused by the AL18 evaporation from the mixed LB film and the increment of thermal mobility of the MS18 hydrocarbon chain. From 110 to 160 degrees C, blue-shifted bands, attributed to the oligomeric MS18 aggregation, appear near 515 nm in the MS18-C 20-AL18 ternary system as well. The temperature at which the 515 nm band occurs is identical for both present ternary system and previously investigated MS18-deuterated arachidic acid (C20- d) binary system, and it is in good agreement with the melting point (110 degrees C) of cadmium arachidate (CdC20). Therefore, it is indicated that the driving force which induces the 515 nm band comes from the melting phenomenon of CdC20 molecules which are phase-separated from MS 18 molecules in as-deposited LB films.

  5. A McCollough Effect Generated at Binocular Site

    Directory of Open Access Journals (Sweden)

    Qiujie Weng

    2011-05-01

    Full Text Available Following exposures to alternating gratings with unique combination of orientation and colors, an achromatic grating would appear tinted with its perceived color contingent on the grating's orientation. This orientation-contingent color after effect is called the McCollough effect. The lack of interocular transfer of the McCollough effect suggests that the McCollough effect is primarily established in monocular channels. Here we explored the possibility that the McCollough effect can be induced at a binocular site. During adaptation, a red vertical grating and a green horizontal grating are dichoptically presented to the two eyes. In the ‘binocular rivalry’ condition, these two gratings were constantly presented throughout the adaptation duration and subjects experienced the rivalry between the two gratings. In the ‘physical alternation’ condition, the two dichoptic gratings physically alternated during adaptation, perceptually similar to binocular rivalry. Interestingly, following dichoptic adaptation either in the rivalry condition or in the physical alternation condition, a binocularly viewed achromatic test grating appeared colored depending on its orientation: a vertical grating appeared greenish and a horizontal grating pinkish. In other words, we observed a McCollough effect following dichoptic adaptation, which can only be explained by a binocular site of orientation-contingent color adaptation.

  6. Tom McCarthy, Karl Marx, and the Money on the Books

    Directory of Open Access Journals (Sweden)

    Nicholas Huber

    2017-11-01

    Full Text Available By way of contrast to recent work on the problematic of representation of capital and its prioritized aesthetic mode, visuality, this article addresses the problematic of mediation in financialized capitalism through an attention to the relationship between writing and contemporary money forms. To elaborate this problematic, mediation is deployed methodologically as well: selections from two bodies of work concerned with capitalist monetary phenomena—those of Karl Marx and the novelist Tom McCarthy—are analyzed in parallel. McCarthy’s 'oeuvre' is presented as preoccupied with monetary-inscriptive techniques and pockmarked by Marxian concepts and concerns. It is argued that 'Remainder', specifically, can be read as theorizing the relationship between money and writing under early 21st-century regimes of finance capital through its elaboration of retail loyalty accounts and the multivalent concept of ‘remainder’ or ‘surplus’. The article reads this theorization against neglected sections of Marx’s second volume of 'Capital' in which money is enigmatically treated from the perspective of bookkeeping.

  7. Ecological effects of contaminants in McCoy Branch, 1989-1990

    Energy Technology Data Exchange (ETDEWEB)

    Ryon, M.G. (ed.)

    1992-01-01

    The 1984 Hazardous and Solid Waste Amendments to the Resource Conservation and Recovery Act (RCRA) required assessment of all current and former solid waste management units. Such a RCRA Facility Investigation (RFI) was required of the Y-12 Plant for their Filled Coal Ash Pond on McCoy Branch. Because the disposal of coal ash in the ash pond, McCoy Branch, and Rogers Quarry was not consistent with the Tennessee Water Quality Act, several remediation steps were implemented or planned for McCoy Branch to address disposal problems. The McCoy Branch RFI plan included provisions for biological monitoring of the McCoy Branch watershed. The objectives of the biological monitoring were to: (1) document changes in biological quality of McCoy Branch after completion of a pipeline and after termination of all discharges to Rogers Quarry, (2) provide guidance on the need for additional remediation, and (3) evaluate the effectiveness of implemented remedial actions. The data from the biological monitoring program will also determine if the classified uses, as identified by the State of Tennessee, of McCoy Branch are being protected and maintained. This report discusses results from toxicity monitoring of snails fish community assessment, and a Benthic macroinvertebrate community assessment.

  8. McArdle disease: a case report and review

    Directory of Open Access Journals (Sweden)

    Leite A

    2012-01-01

    Full Text Available Alberto Leite, Narciso Oliveira, Manuela RochaInternal Medicine Department, Hospital de Braga, PortugalAbstract: McArdle disease (glycogen storage disease type V is a pure myopathy caused by an inherited deficit of myophosphorylase. The disease exhibits clinical heterogeneity, but patients typically experience exercise intolerance, acute crises of early fatigue, and contractures, sometimes with rhabdomyolysis and myoglobinuria, triggered by static muscle contractions or dynamic exercise. We present the case of a 54-year-old man with a lifelong history of fatigability, worsening on exertion. Laboratory evaluation revealed significant elevations in levels of creatine kinase (7924 U/L, lactate dehydrogenase (624 U/L, and myoglobulin (671 ng/mL. A muscle biopsy confirmed the presence of McArdle disease. This case report illustrates how, due to embarrassment, the patient hid his symptoms for many years and was eventually extremely relieved and “liberated” once McArdle disease was diagnosed 40 years later.Keywords: McArdle disease, glycogen storage disease, myophosphorylase

  9. Personal Background Interview of Jim McBarron

    Science.gov (United States)

    McBarron, Jim; Wright, Rebecca

    2012-01-01

    Jim McBarron exhibits a wealth of knowledge gathered from more than 40 years of experience with NASA, EVA, and spacesuits. His biography, progression of work at NASA, impact on EVA and the U.S. spacesuit, and career accomplishments are of interest to many. Wright, from the JSC History Office, conducted a personal background interview with McBarron. This interview highlighted the influences and decision-making methods that impacted McBarron's technical and management contributions to the space program. Attendees gained insight on the external and internal NASA influences on career progression within the EVA and spacesuit, and the type of accomplishments and technical advances that committed individuals can make. He concluded the presentation with a question and answer period that included a brief discussion about close calls and Russian spacesuits.

  10. Visual search for motion-form conjunctions: is form discriminated within the motion system?

    Science.gov (United States)

    von Mühlenen, A; Müller, H J

    2001-06-01

    Motion-form conjunction search can be more efficient when the target is moving (a moving 45 degrees tilted line among moving vertical and stationary 45 degrees tilted lines) rather than stationary. This asymmetry may be due to aspects of form being discriminated within a motion system representing only moving items, whereas discrimination of stationary items relies on a static form system (J. Driver & P. McLeod, 1992). Alternatively, it may be due to search exploiting differential motion velocity and direction signals generated by the moving-target and distractor lines. To decide between these alternatives, 4 experiments systematically varied the motion-signal information conveyed by the moving target and distractors while keeping their form difference salient. Moving-target search was found to be facilitated only when differential motion-signal information was available. Thus, there is no need to assume that form is discriminated within the motion system.

  11. Upper cervical spine movement during intubation: fluoroscopic comparison of the AirWay Scope, McCoy laryngoscope, and Macintosh laryngoscope.

    Science.gov (United States)

    Maruyama, K; Yamada, T; Kawakami, R; Kamata, T; Yokochi, M; Hara, K

    2008-01-01

    The AirWay Scope (AWS) is a new fibreoptic intubation device, which allows visualization of the glottic structures without alignment of the oral, pharyngeal, and tracheal axes, and thus may be useful in patients with limited cervical spine (C-spine) movement. We fluoroscopically evaluated upper C-spine movement during intubation with the AWS or Macintosh or McCoy laryngoscope. Forty-five patients, with normal C-spine, scheduled for elective surgery were randomly assigned to one of the three intubation devices. Movement of the upper C-spine was examined by measuring angles formed by adjacent vertebrae during intubation. Time to intubation was also recorded. Median cumulative upper C-spine movement was 22.3 degrees, 32.3 degrees, and 36.5 degrees with the AWS, Macintosh laryngoscope, and McCoy laryngoscope, respectively (Pmovement of the C-spine at C1/C2 in comparison with the Macintosh or McCoy laryngoscope (P=0.012), and at C3/C4 in comparison with the McCoy laryngoscope (P=0.019). Intubation time was significantly longer in the AWS group than in the Macintosh group (P=0.03). Compared with the Macintosh or McCoy laryngoscope, the AWS produced less movement of upper C-spine for intubation in patients with a normal C-spine.

  12. McStas event logger

    DEFF Research Database (Denmark)

    Bergbäck Knudsen, Erik; Willendrup, Peter Kjær; Klinkby, Esben Bryndt

    2014-01-01

    Functionality is added to the McStas neutron ray-tracing code, which allows individual neutron states before and after a scattering to be temporarily stored, and analysed. This logging mechanism has multiple uses, including studies of longitudinal intensity loss in neutron guides and guide coatin...

  13. McClintock's challenge in the 21st century

    KAUST Repository

    Fedoroff, Nina V.

    2012-11-13

    In 1950, Barbara McClintock published a Classic PNAS article, "The origin and behavior of mutable loci in maize," which summarized the evidence leading to her discovery of transposition. The article described a number of genome alterations revealed through her studies of the Dissociation locus, the first mobile genetic element she identified. McClintock described the suite of nuclear events, including transposon activation and various chromosome aberrations and rearrangements, that unfolded in the wake of genetic crosses that brought together two broken chromosomes 9. McClintock left future generations with the challenge of understanding how genomes respond to genetic and environmental stresses by mounting adaptive responses that frequently include genome restructuring.

  14. Elimination of clonogenic tumor cells from HL-60, Daudi, and U-937 cell lines by laser photoradiation therapy: implications for autologous bone marrow purging

    International Nuclear Information System (INIS)

    Gulliya, K.S.; Pervaiz, S.

    1989-01-01

    Laser photoradiation therapy was tested in an in vitro model for its efficacy in the elimination of non-Hodgkin's lymphoma cells. Results show that at 31.2 J/cm2 of laser light in the presence of 20 micrograms/mL of merocyanine 540 (MC540) there was greater than 5 log reduction in Burkitt's lymphoma (Daudi) cells. Similar tumor cell kill was obtained for leukemia (HL-60) cells at a laser light dose of 93.6 J/cm2. However, to obtain the same efficiency of killing for histiocytic lymphoma (U-937) cells, a higher dose of MC540 (25 micrograms/mL) was required. Clonogenic tumor stem cell colony formation was reduced by greater than 5 logs after laser photoradiation therapy. Under identical conditions for each cell line the percent survival for granulocyte-macrophage colony-forming units (CFU-GM, 45.9%, 40%, 17.5%), granulocyte/erythroid/macrophage/megakaryocyte (GEMM, 40.1%, 20.1%, 11.5%), colony-forming units (CFU-C, 16.2%, 9.1%, 1.8%), and erythroid burst-forming units (BFU-E, 33.4%, 17.8%, 3.9%) was significantly higher than the tumor cells. Mixing of gamma ray-irradiated normal marrow cells with tumor cells (1:1 and 10:1 ratio) did not interfere with the elimination of tumor cells. The effect of highly purified recombinant interferon alpha (rIFN) on laser photoradiation therapy of tumor cells was also investigated. In the presence of rIFN (30 to 3,000 U/mL), the viability of leukemic cells was observed to increase from 0% to 1.5% with a concurrent decrease in membrane polarization, suggesting an increase in fluidity of cell membrane in response to rIFN. However, at higher doses of rIFN (6,000 to 12,000 U/mL) this phenomenon was not observed. The viability of lymphoma cells remained unaffected at all doses of rIFN tested

  15. McEvoy, Kieran; McGregor, Lorna, Transitional Justice from below. Grassroots Activism and the Struggle for Change

    Directory of Open Access Journals (Sweden)

    José M. Atiles-Osoria

    2012-10-01

    Full Text Available El texto editado por Kieran McEvoy y Lorna McGregor representa un esfuerzo por repensar, redefinir e introducir un debate en el seno de la literatura y de las corrientes de estudio sobre la justicia transicional. Generalmente, la justicia transicional ha sido pensada como un conglomerado de estrategias jurídico‑políticas y socio‑económicas implementadas para lidiar con las violaciones de los derechos humanos, con la violencia política del pasado y los procesos de reconstrucción del Estado pos...

  16. Meelis Lao kuulutas eile sõja McDonald'sile / Peeter Raidla

    Index Scriptorium Estoniae

    Raidla, Peeter, 1955-

    2004-01-01

    Ärimees Meelis Lao lasi rendivaidlusele viidates sulgeda Viru tänava kiirtoitlustusasutuse McDonald's. Vt. samas: McDonald'si rendivaidlus küünib aastate taha; McDonald's andis asja politseisse; Meelis Lao kannab probleemide lahendaja tiitlit

  17. Astronauts McNair and Stewart prepare for reentry

    Science.gov (United States)

    1984-01-01

    Astronauts Ronald E. McNair and Robert L. Stewart prepare for the re-entry phase of the shuttle Challenger near the end of the 41-B mission. The are stationed behind the crew commander and pilot. Stewart is already wearing his helmet. McNair is stowing some of his gear.

  18. New developments in the McStas neutron instrument simulation package

    International Nuclear Information System (INIS)

    Willendrup, P K; Knudsen, E B; Klinkby, E; Nielsen, T; Farhi, E; Filges, U; Lefmann, K

    2014-01-01

    The McStas neutron ray-tracing software package is a versatile tool for building accurate simulators of neutron scattering instruments at reactors, short- and long-pulsed spallation sources such as the European Spallation Source. McStas is extensively used for design and optimization of instruments, virtual experiments, data analysis and user training. McStas was founded as a scientific, open-source collaborative code in 1997. This contribution presents the project at its current state and gives an overview of the main new developments in McStas 2.0 (December 2012) and McStas 2.1 (expected fall 2013), including many new components, component parameter uniformisation, partial loss of backward compatibility, updated source brilliance descriptions, developments toward new tools and user interfaces, web interfaces and a new method for estimating beam losses and background from neutron optics.

  19. Drilling and testing specifications for the McGee well

    International Nuclear Information System (INIS)

    Patterson, J.K.

    1982-01-01

    The McGee Well is a part of the Basalt Waste Isolation Project's subsurface site selection and characterization activities. Information from the McGee Well support site hydrologic characterization and repository design. These test specifications include details for the drilling and testing of the McGee. It includes the predicted stratigraphy, the drilling requirements, description of tests to be conducted, intervals selected for hydrologic testing, and a schedule of the drilling and testing activities. 19 refs., 10 figs., 7 tabs

  20. Developing and design a website for mc kalla oy

    OpenAIRE

    Bekele, Henok

    2013-01-01

    This bachelor thesis is about Website development and design. I have a chance to work with Mc kalla Oy. Mc kalla Oy is a construction company from Kempele which was founded 2011. They have projects in Central-Finland, through Northern Finland to Lapland. This thesis is to develop and design a new website to Mc kalla Oy. Wordpress is used to develop the new website. For the development process I use school server (.opiskelijaprojektit.net). The Thesis contains two main parts designing the ...

  1. Integration of OpenMC methods into MAMMOTH and Serpent

    Energy Technology Data Exchange (ETDEWEB)

    Kerby, Leslie [Idaho National Lab. (INL), Idaho Falls, ID (United States); Idaho State Univ., Idaho Falls, ID (United States); DeHart, Mark [Idaho National Lab. (INL), Idaho Falls, ID (United States); Tumulak, Aaron [Idaho National Lab. (INL), Idaho Falls, ID (United States); Univ. of Michigan, Ann Arbor, MI (United States)

    2016-09-01

    OpenMC, a Monte Carlo particle transport simulation code focused on neutron criticality calculations, contains several methods we wish to emulate in MAMMOTH and Serpent. First, research coupling OpenMC and the Multiphysics Object-Oriented Simulation Environment (MOOSE) has shown promising results. Second, the utilization of Functional Expansion Tallies (FETs) allows for a more efficient passing of multiphysics data between OpenMC and MOOSE. Both of these capabilities have been preliminarily implemented into Serpent. Results are discussed and future work recommended.

  2. McDonald’s Corporation - 2015 (MCD

    Directory of Open Access Journals (Sweden)

    Alen Badal

    2017-07-01

    Full Text Available McDonald’s Corporation, 2015 is aiming to enlighten the “Experience of the Future” for consumers, with a special focus on the ‘younger’ generation. Beginning in 2015 and moving forward, McDonald’s has operationalized the functions of its strategy to bett er serve consumers with such offerings as trial-testing a build-your-burger strategy with the order being served at the table, known as the “Create Your Taste” program. The restaurant chain has introduced the all-day breakfast menu and ‘McPick 2’ for $5.00. Additionally, the company has engaged consumers by way of social media and is interested in having a smart phone application in use. Other roll-outs include processing transactions by way of mobile-payment with such channels as ‘Google Wallet, Soft card and Apple Pay.’ The fast-food giant continues to test a variety of strategies at select locations aimed at increasing shareholder value as a result of both introducing and modifying the point-of-sale services and food & beverage offerings¹.

  3. Ecological effects of contaminants in McCoy Branch, 1991--1993

    Energy Technology Data Exchange (ETDEWEB)

    Ryon, M.G. [ed.

    1996-09-01

    The 1984 Hazardous and Solid Waste Amendments to the Resource Conservation and Recovery Act (RCRA) required assessment of all current and former solid waste management units. Following guidelines under RCRA and the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), a remedial investigation (RI) was required of the Y-12 Plant for their filled coal ash pond (FCAP) and associated areas on McCoy Branch. The RI process was initiated and assessments were presented. Because the disposal of coal ash in the ash pond, McCoy Branch, and Rogers Quarry was not consistent with the Tennessee Water Quality Act, several remediation steps were implemented between 1986 and 1994 for McCoy Branch to address disposal problems. The required ecological risk assessments of McCoy Branch watershed included provisions for biological monitoring of the watershed. The objectives of the biological monitoring were to (1) document changes in biological quality of McCoy Branch after completion of a pipeline bypassing upper McCoy Branch and further, after termination of all discharges to Rogers Quarry, (2) provide guidance on the need for additional remediation, and (3) evaluate the effectiveness of implemented remedial actions. The data from the biological monitoring program may also determine whether the goals of protection of human health and the environment of McCoy Branch are being accomplished.

  4. Red hair is the null phenotype of MC1R.

    Science.gov (United States)

    Beaumont, Kimberley A; Shekar, Sri N; Cook, Anthony L; Duffy, David L; Sturm, Richard A

    2008-08-01

    The Melanocortin-1 Receptor (MC1R) is a G-protein coupled receptor, which is responsible for production of the darker eumelanin pigment and the tanning response. The MC1R gene has many polymorphisms, some of which have been linked to variation in pigmentation phenotypes within human populations. In particular, the p.D84E, p.R151C, p.R160W and p.D294 H alleles have been strongly associated with red hair, fair skin and increased skin cancer risk. These red hair colour (RHC) variants are relatively well described and are thought to result in altered receptor function, while still retaining varying levels of signaling ability in vitro. The mouse Mc1r null phenotype is yellow fur colour, the p.R151C, p.R160W and p.D294 H alleles were able to partially rescue this phenotype, leading to the question of what the true null phenotype of MC1R would be in humans. Due to the rarity of MC1R null alleles in human populations, they have only been found in the heterozygous state until now. We report here the first case of a homozygous MC1R null individual, phenotypic analysis indicates that red hair and fair skin is found in the absence of MC1R function.

  5. Eccentric Voices and the Representation of Vocal Virtuosity in Fiction: James McCourt’s Mawrdew Czgowchwz

    Directory of Open Access Journals (Sweden)

    Marcin Stawiarski

    2016-06-01

    Full Text Available This paper examines the representation of vocal virtuosity in fiction. It focuses on the concept of voice as it is represented in a work of fiction through musical eccentricity. The paper centres on James McCourt’s Mawrdew Czgowchwz (1975. James McCourt’s novel tells the story of an opera singer, Mawrdew Czgowchwz. In the novel, the voice is related to extravagance and fanaticism, so that it relates to violence and conflict. In McCourt’s novel, the stylistic features of the text show a hyperbolic use of language resorting to Rabelaisian lists, foreign vocabulary, neologisms, or nonce-words, which create tongue-twister cornucopia effects of linguistic musicality. The paper aims to demonstrate that (a the mode of eccentricity is a fundamental mode of representing music in literature; (b eccentricity rubs off on the very structure of the text, so that it leads to singular forms of operatic musicalization of fiction and musicalized writing; (c the voice ends up turning into a fetish object.

  6. McCarthyism and American Opera L’Opéra américain face au McCarthyisme

    Directory of Open Access Journals (Sweden)

    Klaus-Dieter Gross

    2009-11-01

    Full Text Available L’atmosphère anti-communiste qui caractérisa les États-Unis entre la fin de la seconde Guerre Mondiale et la fin des années 1950, et qui culmina avec des mesures légales ou extra-légales prises par le Comité des Activités Anti-américaines et par le sénateur McCarthy, eut une influence décisive sur l’opéra américain. Quelques rares ouvrages manifestent un soutien diffus pour le McCarthyisme (Still et Nabobov, tandis que d’autres nient son impact en promouvant des idées de gauche (Robinson et Blitzstein. D’autres œuvres incorporent la peur de la vague rouge dans leurs thèmes, mais sans lui donner une importance autre que secondaire. Enfin, trois opéras (Bernstein, Floyd et Ward abordent frontalement la question du fonctionnement rituel et des méthodes liberticides du McCarthyisme. Le déclin de ce mouvement coïncida, vers le début des années 1960, avec l’émergence d’un style opératique moins traditionaliste et plus abstrait.

  7. Is McMurray′s osteotomy obsolete?

    Directory of Open Access Journals (Sweden)

    Phaltankar P

    1995-10-01

    Full Text Available A review of the method of performing, advantages, disadvantages of McMurray′s displacement osteotomy with regard to treatment of nonunion of transcervical fracture neck femur with viable femoral head was carried out in this study of ten cases, in view of the abandonment of the procedure in favour of angulation osteotomy. Good results obtained in the series attest to the usefulness of McMurray′s osteotomy in the difficult problem of nonunion of transcervical fracture neck femur in well selected cases with certain advantages over the angulation osteotomy due to the ′Armchair effect′.

  8. An Interview with Joe McMann: His Life Lessons

    Science.gov (United States)

    McMann, Joe

    2011-01-01

    Pica Kahn conducted "An Interview with Joe McMann: His Life Lessons" on May 23, 2011. With over 40 years of experience in the aerospace industry, McMann has gained a wealth of knowledge. Many have been interested in his biography, progression of work at NASA, impact on the U.S. spacesuit, and career accomplishments. This interview highlighted the influences and decision-making methods that impacted his technical and management contributions to the space program. McMann shared information about the accomplishments and technical advances that committed individuals can make.

  9. On coincidence of Pettis and McShane integrability

    Czech Academy of Sciences Publication Activity Database

    Fabian, Marián

    2015-01-01

    Roč. 65, č. 1 (2015), s. 83-106 ISSN 0011-4642 R&D Projects: GA ČR(CZ) GAP201/12/0290 Institutional support: RVO:67985840 Keywords : Pettis integral * McShane integral * MC-filling family Subject RIV: BA - General Mathematics Impact factor: 0.284, year: 2015 http://link.springer.com/article/10.1007/s10587-015-0161-x

  10. Hesburger asub ründama, McDonalds teeb kaevikuid / Andres Reimer

    Index Scriptorium Estoniae

    Reimer, Andres

    2005-01-01

    Hesburger tahab Eestis oma restoranide hulka kolmekordistada. McDonald's Eestis ei laiene, kuid kavatseb ettevõtte efektiivsust suurendada. Eesti hamburgerirestoranide kett Nehatu on konkurentsist välja langenud. Tabelid: Tulemused; Hamburgerirestoranid Eestis; Hamburger ja McDonald's maailmas. Lisad: Hakkas Hesburgeri partneriks; Hakka McDonald'si partneriks

  11. A Comparison of the McMaster and Circumplex Family Assessment Instruments.

    Science.gov (United States)

    Fristad, Mary A.

    1989-01-01

    Compared clinical rating scales and self-report scales from McMaster and Circumplex models of family functioning with families (N=41). Found McMaster instruments had superior sensitivity; greater correspondence between clinical rating scales and family member self-report inventories on McMaster instruments; and lack of support for the curvilinear…

  12. Angus McBean - Portraits

    NARCIS (Netherlands)

    Pepper, T.

    2007-01-01

    Angus McBean (1904-90) was one of the most extraordinary British photographers of the twentieth century. In a career that spanned the start of the Second World War through the birth of the 'Swinging Sixties' to the 1980s, he became the most prominent theatre photographer of his generation and, along

  13. Sex-specific allelic transmission bias suggests sexual conflict at MC1R.

    Science.gov (United States)

    Ducret, Valérie; Gaigher, Arnaud; Simon, Céline; Goudet, Jérôme; Roulin, Alexandre

    2016-09-01

    Sexual conflict arises when selection in one sex causes the displacement of the other sex from its phenotypic optimum, leading to an inevitable tension within the genome - called intralocus sexual conflict. Although the autosomal melanocortin-1-receptor gene (MC1R) can generate colour variation in sexually dichromatic species, most previous studies have not considered the possibility that MC1R may be subject to sexual conflict. In the barn owl (Tyto alba), the allele MC1RWHITE is associated with whitish plumage coloration, typical of males, and the allele MC1RRUFOUS is associated with dark rufous coloration, typical of females, although each sex can express any phenotype. Because each colour variant is adapted to specific environmental conditions, the allele MC1RWHITE may be more strongly selected in males and the allele MC1RRUFOUS in females. We therefore investigated whether MC1R genotypes are in excess or deficit in male and female fledglings compared with the expected Hardy-Weinberg proportions. Our results show an overall deficit of 7.5% in the proportion of heterozygotes in males and of 12.9% in females. In males, interannual variation in assortative pairing with respect to MC1R explained the year-specific deviations from Hardy-Weinberg proportions, whereas in females, the deficit was better explained by the interannual variation in the probability of inheriting the MC1RWHITE or MC1RRUFOUS allele. Additionally, we observed that sons inherit the MC1RRUFOUS allele from their fathers on average slightly less often than expected under the first Mendelian law. Transmission ratio distortion may be adaptive in this sexually dichromatic species if males and females are, respectively, selected to display white and rufous plumages. © 2016 John Wiley & Sons Ltd.

  14. Evaluation of uranium anomalies in the McCaslin Syncline, northeastern Wisconsin

    International Nuclear Information System (INIS)

    Blackburn, W.H.; Mathews, G.W.

    1982-01-01

    On the basis of this investigation, the McCaslin area does not demonstrate sufficient recognition criteria to be considered favorable for the occurrence of uranium deposits that are analogous to quartz-pebble conglomerate deposits or unconformity-related deposits. Neither model is applicable because: (1) More often than not the conglomeratic lenses of the McCaslin Quartzite are polymictic. (2) Pyrite and chlorite are essentially lacking; (3) Pervasive chloritic and hematitic alteration are not present in the McCaslin district; (4) The maximum estimated age of the McCaslin is 1.9 b.y.; (5) The notable absence of anomalous uranium values in the basal McCaslin Quartzite, and especially where known faulting intersects the McCaslin, suggests that a process for concentrating uranium has not been effective in the area; (6) The Waupee Volcanics are not known to contain any extensive graphitic or chloritic schists, nor do they have more than normal amounts of uranium; (7) Uranium anomalies in stream-water, stream-sediment, and aerial surveys may be explained by uranium derived from the relatively uraniferous Hager Rhyolite, or other granitic intrusives related to the Wolf River batholith. The McCaslin area warrants no further investigation; it will not contribute any significant new potential the the NURE resource base. 3 figures, 3 tables

  15. Iconicity and Typography in Steve McCaffery’s Panel-Poems Iconicité et typographie chez Steve McCaffery: les poèmes-panneaux

    Directory of Open Access Journals (Sweden)

    Fiona McMahon

    2007-01-01

    Full Text Available Cet article se propose de retracer les étapes d’un projet d’écriture qui se rattache historiquement aux mouvances internationales de la poésie concrète comme à l’émergence d’une poétique de l’iconicité chez l’avant-garde nord-américaine du vingtième siècle. Le matérialisme dont se réclame la poésie de Steve McCaffery se traduit dans son œuvre typographique Carnival (1967-75 par une pratique mettant en jeu la lettre, le plus petit dénominateur de la langue, et la page, qui doit se laisser transformer pour que se réalise un nouvel espace de signification poétique. Le dialogue qui se joue entre le lisible et le visible prend forme grâce à un répertoire de techniques expérimenté avec la machine à écrire et de concert avec le lecteur, devenu acteur de l’œuvre poétique. La pratique architecturale du poème-panneau chez McCaffery sera envisagée dans son rapport actuel avec le prolongement des problématiques de la poésie visuelle chez l’avant-garde nord-américaine.

  16. Development of performance tests for an automated MC and A system

    International Nuclear Information System (INIS)

    Kok, K.D.; Klingensmith, R.W.; Riffle, W.; Carver, R.D.; Schumacher, S.S.; Lavender, J.C.; Smith, B.W.

    1988-01-01

    Performance tests of MC and A systems using computers are described, and some example scenarios are discussed. Facility personnel or an external inspection group may use performance tests to evaluate MC and A capabilities under actual operating conditions. This paper addresses test elements common to both user groups. Performance tests consist of scenario development, security, and safety measures, conduct, and evaluation. Because exercises often test scenarios against which the MC and A system is protecting, they may require additional security and safety measures. Computer systems enhance MC and A by providing greater speed, increased precision, and automated checks. Performance tests for MC and A systems using computers differ from performance tests employing manual data systems in that the scenarios must anticipate computer actions rather than utilize controllers to adjust the scenario

  17. Entrevista com Eric McLuhan

    Directory of Open Access Journals (Sweden)

    McLuhan, Eric

    2011-01-01

    Full Text Available Marshall McLuhan faria 100 anos em 2011. Para marcar esta data, que já provocou uma recente revisitação à obra do teórico, o XI Seminário Internacional da Comunicação, promovido pela PUCRS, destacou temas como as relações do homem com as tecnologias e os efeitos psicológicos das mídias para nortear às discussões dos três dias de evento. Mas se engana que acredita que entender a obra mcluhiana é tarefa fácil. Mesmo tendo se dedicado com afinco a explicar metáforas como ‘o meio é a mensagem’ e ‘aldeia global’, McLuhan nunca chegou a ser completamente entendido. Ou as pessoas não sedavam ao trabalho de entendê-lo, ou, simplesmente, não conseguiam enxergar as mudanças que estavam acontecendo com a mesma clareza que o pesquisador. Numa tentativa não só de entender a obra do ‘profeta da globalização’, mas de ampliar os entendimentos sobre as tecnologias e as extensões do homem, Eric McLuhan, filho do teórico, participou como palestrante do Seminário para falar, entre outros assuntos, da percepção acadêmica quanto a obra de seu pai, além de introduzir novas ideias sobre televisão, globalização e ecologia

  18. Reductionist Challenges to Explanatory Pluralism : Comment on McCauley

    NARCIS (Netherlands)

    Eronen, Markus I.

    2009-01-01

    In this comment, I first point out some problems in McCauley's defense of the traditional conception of general analytical levels. Then I present certain reductionist arguments against explanatory pluralism that are not based on the New Wave model of intertheoretic reduction, against which McCauley

  19. ATLAS Monte Carlo tunes for MC09

    CERN Document Server

    The ATLAS collaboration

    2010-01-01

    This note describes the ATLAS tunes of underlying event and minimum bias description for the main Monte Carlo generators used in the MC09 production. For the main shower generators, pythia and herwig (with jimmy), the MRST LO* parton distribution functions (PDFs) were used for the first time in ATLAS. Special studies on the performance of these, conceptually new, PDFs for high pt physics processes at LHC energies are presented. In addition, a tune of jimmy for CTEQ6.6 is presented, for use with MC@NLO.

  20. Mickey Mouse poses with a portrait of Ronald McNair

    Science.gov (United States)

    1999-01-01

    In the gymnasium of Ronald McNair Magnet School in Cocoa, Fla., Mickey Mouse poses with a portrait of NASA astronaut Ronald McNair. The portrait was presented to the school by Walt Disney World during a tribute to McNair. The school had previously been renamed for the fallen astronaut who was one of a crew of seven who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

  1. The great war correspondent: Francis McCullagh, 1874–1956

    OpenAIRE

    Horgan, John

    2009-01-01

    Trotsky of Russia knows Francis McCullagh. So does President Calles of Mexico. Peter, the King of Serbia, was McCullagh’s friend. The headhunters of the upper Amazon list Francis McCullagh as one of their principal deities. The warring tribes of Morocco call him blood brother. A room is always ready for him in the imperial palace of Siam. The latchstrings of hundreds of Siberian peasant huts are out in anticipation of his coming.

  2. Esther McCready, RN: Nursing Advocate for Civil Rights

    Science.gov (United States)

    Pollitt, Phoebe A

    2016-02-15

    More than a decade before the Civil Rights Act of 1964, as an African American teenager from Baltimore, Maryland, Esther McCready challenged the discriminatory admissions policies of the University of Maryland School of Nursing (UMSON). The article explores nurse advocacy and how Esther McCready advocated for herself and greater racial equity in nursing education during a time of civil rights turmoil. Her actions eventually resulted in the formation of numerous schools of nursing for African Americans across the south. This article recounts McCready’s early life experiences and the powerful impact her actions had on creating educational options for nurses during a time when they were severely limited for African American women, including discussion of her student days at UMSON and her journey after nursing school. A review of pertinent legal cases and policies related to segregation and integration of higher education in the mid-twentieth century is presented, along with details of McCready’s continued education and advocacy.

  3. Truncation of the many body hierarchy and relaxation times in the McKean model

    International Nuclear Information System (INIS)

    Schmitt, K.J.

    1987-01-01

    In the McKean model the BBGKY-hierarchy is equivalent to a simple hierarchy of coupled equations for the p-particle correlation functions. Truncation effects and the convergence of the one-particle distribution towards its exact shape have been studied. In the long time limit the equations can be solved in a closed form. It turns out that the p-particle correlation decays p-times faster than the non-equilibrium one-particle distribution

  4. TRUNCATION OF THE MANY BODY HIERARCHY AND RELAXATION TIMES IN THE McKEAN MODEL

    OpenAIRE

    Schmitt , K.-J.

    1987-01-01

    In the McKean model the BBGKY-hierarchy is equivalent to a simple hierarchy of coupled equations for the p-particle correlation functions. Truncation effects and the convergence of the one-particle distribution towards its exact shape have been studied. In the long time limit the equations can be solved in a closed form. It turns out that the p-particle correlation decays p-times faster than the non-equilibrium one-particle distribution.

  5. Differential Muscle Involvement in Mice and Humans Affected by McArdle Disease

    DEFF Research Database (Denmark)

    Krag, Thomas O; Pinós, Tomàs; Nielsen, Tue L

    2016-01-01

    McArdle disease (muscle glycogenosis type V) is caused by myophosphorylase deficiency, which leads to impaired glycogen breakdown. We investigated how myophosphorylase deficiency affects muscle physiology, morphology, and glucose metabolism in 20-week-old McArdle mice and compared the findings...... to those in McArdle disease patients. Muscle contractions in the McArdle mice were affected by structural degeneration due to glycogen accumulation, and glycolytic muscles fatigued prematurely, as occurs in the muscles of McArdle disease patients. Homozygous McArdle mice showed muscle fiber disarray...... no substitution for the missing muscle isoform. In the mice, the tibialis anterior (TA) muscles were invariably more damaged than the quadriceps muscles. This may relate to a 7-fold higher level of myophosphorylase in TA compared to quadriceps in wild-type mice and suggests higher glucose turnover in the TA. Thus...

  6. Philip McLaren and the Indigenous-Australian Crime Novel

    Directory of Open Access Journals (Sweden)

    Cornelis Martin Renes

    2017-01-01

    Full Text Available This paper locates the postcolonial crime novel as a space for disenfranchised groups to write back to the marginalisation inherent in the process of colonisation, and explores the example of Australia. From its inception in the mid-19th century, Australian crime fiction reflected upon the challenging harshness and otherness of the Australian experience for the free and convict settler, expelled from the metropole. It created a series of popular subgenres derived from the convict narrative proper, while more ‘standard’ modes of crime fiction, popularised in and through British and American crime fiction, were late to develop. Whereas Australian crime fiction has given expression to the white experience of the continent in manifold ways, up until recently it made no room for Indigenous voices – with the exception of the classic Inspector Napoleon Bonaparte series written by the prolific Arthur Upfield in the first half of the 20th century. For the longest time, this absence reflected the dispossession, dispersal and disenfranchisement of the colonised Indigenous peoples at large; there were neither Aboriginal voices nor Aboriginal authors, which made the textual space of the Australian crime novel a discursive terra nullius. This paper will look at the only Indigenous-Australian author to date with a substantial body of work in crime fiction, Philip McLaren, and elucidate how his four crime novels break new ground in Australian crime fiction by embedding themselves within a political framework of Aboriginal resilience and resistance to neo/colonialism. Written as of the 1990s, McLaren’s oeuvre is eclectic in that it does not respond to traditional formats of Australian crime fiction, shifts between generic subtypes and makes incursions into other genres. The paper concludes that McLaren’s oeuvre has not been conceived of as the work of a crime writer per se, but rather that its form and content are deeply informed by the racist violence

  7. Obama ja McCaini lugu Ameerika presidendivalimistel : kes võidab? / Jonatan Vseviov

    Index Scriptorium Estoniae

    Vseviov, Jonatan

    2008-01-01

    Autor analüüsib USA presidendikandidaatide Barack Obama ja John McCaini valimiskampaaniat, sellel ajal esitatavat lugu minevikust ja tulevikust, kus keskseks tegelaseks on kandidaat ise ning asepresidendikandidaatide valikut. Obamal on muutuste narratiiv - soov muuta senist poliitikat, McCainil aga narratiiv kogemustest ja sõltumatusest. Vt. samas: Barack Obama; John McCain; Hendrik Vosman. Obama valmistub koostama staaride kabinetti; Evelyn Kaldoja. Michelle Obamat võrreldakse Jackie Kennedyga; Missioonitundega õlleprintsess Cindy Hensley McCain

  8. Validation of Shielding Analysis Capability of SuperMC with SINBAD

    Directory of Open Access Journals (Sweden)

    Chen Chaobin

    2017-01-01

    Full Text Available Abstract: The shielding analysis capability of SuperMC was validated with the Shielding Integral Benchmark Archive Database (SINBAD. The SINBAD was compiled by RSICC and NEA, it includes numerous benchmark experiments performed with the D-T fusion neutron source facilities of OKTAVIAN, FNS, IPPE, etc. The results from SuperMC simulation were compared with experimental data and MCNP results. Very good agreement with deviation lower than 1% was achieved and it suggests that SuperMC is reliable in shielding calculation.

  9. MC-PDFT can calculate singlet-triplet splittings of organic diradicals

    Science.gov (United States)

    Stoneburner, Samuel J.; Truhlar, Donald G.; Gagliardi, Laura

    2018-02-01

    The singlet-triplet splittings of a set of diradical organic molecules are calculated using multiconfiguration pair-density functional theory (MC-PDFT), and the results are compared with those obtained by Kohn-Sham density functional theory (KS-DFT) and complete active space second-order perturbation theory (CASPT2) calculations. We found that MC-PDFT, even with small and systematically defined active spaces, is competitive in accuracy with CASPT2, and it yields results with greater accuracy and precision than Kohn-Sham DFT with the parent functional. MC-PDFT also avoids the challenges associated with spin contamination in KS-DFT. It is also shown that MC-PDFT is much less computationally expensive than CASPT2 when applied to larger active spaces, and this illustrates the promise of this method for larger diradical organic systems.

  10. Autoradiographic imaging of the serotonin transporter, using S-[18F](fluoromethyl)-(+)-McN5652 ([18F]Me-McN) in the brains of several animal species

    International Nuclear Information System (INIS)

    Kretzschmar, M.; Zessin, J.; Brust, P.; Cumming, P.; Bergmann, R.

    2002-01-01

    The [ 18 F]fluoromethyl analogue of (+)-McN5652 ([ 18 F]Me-McN) was recently proposed as a new potential PET tracer [1]. To further validate its use in PET, we studied the binding of [ 18 F]Me-McN in the brains of rats and pigs using autoradiography. The binding was compared with the uptake of the known 5-HT uptake inhibitor [ 3 H] citalopram [2] and the radioligand (+)-[ 11 C]McN5652. The binding of the three compounds was qualitatively identical in the autoradiograms of the individual brains. Intense labelling was observed in regions known to be serotonin uptake sites. The binding was specifically inhibited, using the 5-HT uptake inhibitors citalopram and fluoxetine. (orig.)

  11. VERA Pin and Fuel Assembly Depletion Benchmark Calculations by McCARD and DeCART

    Energy Technology Data Exchange (ETDEWEB)

    Park, Ho Jin; Cho, Jin Young [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    Monte Carlo (MC) codes have been developed and used to simulate a neutron transport since MC method was devised in the Manhattan project. Solving the neutron transport problem with the MC method is simple and straightforward to understand. Because there are few essential approximations for the 6- dimension phase of a neutron such as the location, energy, and direction in MC calculations, highly accurate solutions can be obtained through such calculations. In this work, the VERA pin and fuel assembly (FA) depletion benchmark calculations are performed to examine the depletion capability of the newly generated DeCART multi-group cross section library. To obtain the reference solutions, MC depletion calculations are conducted using McCARD. Moreover, to scrutinize the effect by stochastic uncertainty propagation, uncertainty propagation analyses are performed using a sensitivity and uncertainty (S/U) analysis method and stochastic sampling (S.S) method. It is still expensive and challenging to perform a depletion analysis by a MC code. Nevertheless, many studies and works for a MC depletion analysis have been conducted to utilize the benefits of the MC method. In this study, McCARD MC and DeCART MOC transport calculations are performed for the VERA pin and FA depletion benchmarks. The DeCART depletion calculations are conducted to examine the depletion capability of the newly generated multi-group cross section library. The DeCART depletion calculations give excellent agreement with the McCARD reference one. From the McCARD results, it is observed that the MC depletion results depend on how to split the burnup interval. First, only to quantify the effect of the stochastic uncertainty propagation at 40 DTS, the uncertainty propagation analyses are performed using the S/U and S.S. method.

  12. McGuire snubber elimination program

    International Nuclear Information System (INIS)

    Cloud, R.L.; Leung, J.S.M.; Taylor, W.H.; Morgan, R.L. Jr.

    1993-01-01

    An engineering program has been initiated at McGuire Nuclear Stations 1 and 2 to eliminate all existing snubbers. The elimination is achieved by replacing existing snubbers with limit stop pipe supports. The program establishes plant-wide modification procedures for one-to-one substitution under the 10 CFR 50.59 requirement. Nuclear Regulatory Commission (NRC) acceptance is based on the results of both comparison analyses and the hardware implementation of sample piping systems at McGuire nuclear stations. Experimental results obtained on shake table testing and from the NRC sponsored HDR research program are also used to formulate the technical basis and design procedures for plant-wide implementation of the snubber replacement effort. The overall program plan is for nearly 3,000 snubbers to be replaced in phases consistent with the plant scheduled outages. Duke Power estimates the program, when completed, will maintain ALARA, improve reliability, and reduce plant operating costs

  13. 78 FR 17646 - Agency Information Collection Activities; Comment Request; Ronald E. McNair Postbaccalaureate...

    Science.gov (United States)

    2013-03-22

    ...; Comment Request; Ronald E. McNair Postbaccalaureate Achievement Program Annual Performance Report AGENCY... of Collection: Ronald E. McNair Postbaccalaureate Achievement Program Annual Performance Report. OMB...: Ronald E. McNair Postbaccalaureate Achievement (McNair) Program Annual Performance Report Program...

  14. MC1R and the response of melanocytes to ultraviolet radiation

    International Nuclear Information System (INIS)

    Rouzaud, Francois; Kadekaro, Ana Luisa; Abdel-Malek, Zalfa A.; Hearing, Vincent J.

    2005-01-01

    The constitutive color of our skin plays a dramatic role in our photoprotection from solar ultraviolet radiation (UVR) that reaches the Earth and in minimizing DNA damage that gives rise to skin cancer. More than 120 genes have been identified and shown to regulate pigmentation, one of the key genes being melanocortin 1 receptor (MC1R) that encodes the melanocortin 1 receptor (MC1R), a seven-transmembrane G protein-coupled receptor expressed on the surface of melanocytes. Modulation of MC1R function regulates melanin synthesis by melanocytes qualitatively and quantitatively. The MC1R is regulated by the physiological agonists α-melanocyte-stimulating hormone (αMSH) and adrenocorticotropic hormone (ACTH), and antagonist agouti signaling protein (ASP). Activation of the MC1R by binding of an agonist stimulates the synthesis of eumelanin primarily via activation of adenylate cyclase. The significance of cutaneous pigmentation lies in the photoprotective effect of melanin, particularly eumelanin, against sun-induced carcinogenesis. Epidermal melanocytes and keratinocytes respond to UVR by increasing their expression of αMSH and ACTH, which up-regulate the expression of MC1R, and consequently enhance the response of melanocytes to melanocortins. Constitutive skin pigmentation dramatically affects the incidence of skin cancer. The pigmentary phenotype characterized by red hair, fair complexion, inability to tan and tendency to freckle is an independent risk factor for all skin cancers, including melanoma. The MC1R gene is highly polymorphic in human populations, and allelic variation at this locus accounts, to a large extent, for the variation in pigmentary phenotypes and skin phototypes (SPT) in humans. Several allelic variants of the MC1R gene are associated with the red hair and fair skin (RHC) phenotype, and carrying one of these variants is thought to diminish the ability of the epidermis to respond to DNA damage elicited by UVR. The MC1R gene is considered a

  15. MC1R and the response of melanocytes to ultraviolet radiation

    Energy Technology Data Exchange (ETDEWEB)

    Rouzaud, Francois [Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Building 37, Room 2132, Bethesda, MD 20892 (United States); Kadekaro, Ana Luisa [Department of Dermatology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267 (United States); Abdel-Malek, Zalfa A. [Department of Dermatology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267 (United States); Hearing, Vincent J. [Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Building 37, Room 2132, Bethesda, MD 20892 (United States)]. E-mail: hearingv@nih.gov

    2005-04-01

    The constitutive color of our skin plays a dramatic role in our photoprotection from solar ultraviolet radiation (UVR) that reaches the Earth and in minimizing DNA damage that gives rise to skin cancer. More than 120 genes have been identified and shown to regulate pigmentation, one of the key genes being melanocortin 1 receptor (MC1R) that encodes the melanocortin 1 receptor (MC1R), a seven-transmembrane G protein-coupled receptor expressed on the surface of melanocytes. Modulation of MC1R function regulates melanin synthesis by melanocytes qualitatively and quantitatively. The MC1R is regulated by the physiological agonists {alpha}-melanocyte-stimulating hormone ({alpha}MSH) and adrenocorticotropic hormone (ACTH), and antagonist agouti signaling protein (ASP). Activation of the MC1R by binding of an agonist stimulates the synthesis of eumelanin primarily via activation of adenylate cyclase. The significance of cutaneous pigmentation lies in the photoprotective effect of melanin, particularly eumelanin, against sun-induced carcinogenesis. Epidermal melanocytes and keratinocytes respond to UVR by increasing their expression of {alpha}MSH and ACTH, which up-regulate the expression of MC1R, and consequently enhance the response of melanocytes to melanocortins. Constitutive skin pigmentation dramatically affects the incidence of skin cancer. The pigmentary phenotype characterized by red hair, fair complexion, inability to tan and tendency to freckle is an independent risk factor for all skin cancers, including melanoma. The MC1R gene is highly polymorphic in human populations, and allelic variation at this locus accounts, to a large extent, for the variation in pigmentary phenotypes and skin phototypes (SPT) in humans. Several allelic variants of the MC1R gene are associated with the red hair and fair skin (RHC) phenotype, and carrying one of these variants is thought to diminish the ability of the epidermis to respond to DNA damage elicited by UVR. The MC1R gene is

  16. McCullough to Liberty fiber optics project

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-05-01

    The US Department of Energy, Western Area Power Administration (Western) proposes to replace an existing overhead static wire with a shield wire that contains optical fibers (OPGW) on transmission lines from McCullough Substation, south of Las Vegas, Nevada, to Liberty Substation near Phoenix, Arizona. The replacement will occur on the McCullough-Davis, Davis-Parker No. 2, and Parker-Liberty No. 1 230-kV transmission lines. Western is responsible for the operation and maintenance of the lines. Western prepared an Environmental Assessment (EA) entitled ``McCullough to Liberty Fiber Optics Project`` (DOE/EA-1202). The EA contains the analysis of the proposed construction, operation, and maintenance of the OPGW. Based on the analysis in the EA, Western finds that the proposed action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. The preparation of an environmental impact statement (EIS) is not required, and therefore, Western is issuing this Findings of No Significant Impact (FONSI).

  17. McCullough to Liberty fiber optics project

    International Nuclear Information System (INIS)

    1997-05-01

    The US Department of Energy, Western Area Power Administration (Western) proposes to replace an existing overhead static wire with a shield wire that contains optical fibers (OPGW) on transmission lines from McCullough Substation, south of Las Vegas, Nevada, to Liberty Substation near Phoenix, Arizona. The replacement will occur on the McCullough-Davis, Davis-Parker No. 2, and Parker-Liberty No. 1 230-kV transmission lines. Western is responsible for the operation and maintenance of the lines. Western prepared an Environmental Assessment (EA) entitled ''McCullough to Liberty Fiber Optics Project'' (DOE/EA-1202). The EA contains the analysis of the proposed construction, operation, and maintenance of the OPGW. Based on the analysis in the EA, Western finds that the proposed action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. The preparation of an environmental impact statement (EIS) is not required, and therefore, Western is issuing this Findings of No Significant Impact (FONSI)

  18. Sygeplejefagets teorigrundlag som værn mod McDonaldisering

    DEFF Research Database (Denmark)

    Norlyk, Annelise; Haahr, Anita; Dreyer, Pia

    2017-01-01

    , and that values from evidence-based medicine are being lost in the transformation into this practice which potentially leads to a McDonaldization of nursing practice reflected as «one best way». To prevent a practice of «McNursing», we argue for reviving ethics of care perspectives in today’s evidence practice...

  19. Postavení firmy McDonald's na trhu v USA

    OpenAIRE

    Holkupová, Jitka

    2012-01-01

    This thesis deals with McDonald's and its current position in the U.S. market. The first chapter focuses on the company's history from the very beginnings to the present. It explains what was behind the success of McDonald's and how the company is different from most competitors. The second chapter focuses on the current situation in the U.S. market, the role of franchising in the fast food industry and McDonald's compared with its main competitors. The subject of the third chapter is the SWO...

  20. New developments in the McStas neutron instrument simulation package

    DEFF Research Database (Denmark)

    Willendrup, Peter Kjær; Bergbäck Knudsen, Erik; Klinkby, Esben Bryndt

    2014-01-01

    , virtual experiments, data analysis and user training. McStas was founded as a scienti_c, open-source collaborative code in 1997. This contribution presents the project at its current state and gives an overview of the main new developments in McStas 2.0 (December 2012) and McStas 2.1 (expected fall 2013......), including many new components, component parameter uniformisation, partial loss of backward compatibility, updated source brilliance descriptions, developments toward new tools and user interfaces, web interfaces and a new method for estimating beam losses and background from neutron optics....

  1. McArdle Disease

    DEFF Research Database (Denmark)

    Santalla, Alfredo; Nogales-Gadea, Gisela; Ørtenblad, Niels

    2014-01-01

    McArdle disease is arguably the paradigm of exercise intolerance in humans. This disorder is caused by inherited deficiency of myophosphorylase, the enzyme isoform that initiates glycogen breakdown in skeletal muscles. Because patients are unable to obtain energy from their muscle glycogen stores......, this disease provides an interesting model of study for exercise physiologists, allowing insight to be gained into the understanding of glycogen-dependent muscle functions. Of special interest in the field of muscle physiology and sports medicine are also some specific (if not unique) characteristics...

  2. Brad Patterson, Tom Brooking, and Jim McAloon, Unpacking the Kist: The Scots in New Zealand. McGill-Queen's Studies in Ethnic History Series, No. 2.33. Montreal: McGill-Queen’s University Press, 2013. Pp. 412. ISBN 978-0-7735-4190-0. CAD $100.00.

    Directory of Open Access Journals (Sweden)

    Seán Gerard Brosnahan

    2014-11-01

    Full Text Available Brad Patterson, Tom Brooking, and Jim McAloon, Unpacking the Kist: The Scots in New Zealand. McGill-Queen's Studies in Ethnic History Series, No. 2.33. Montreal: McGill-Queen’s University Press, 2013. Pp. 412. ISBN 978-0-7735-4190-0. CAD $100.00.

  3. Effects of an inhibitor of phosphoenolpyruvate carboxylase on photosynthesis of the terrestrial forms of amphibious Eleocharis species.

    Science.gov (United States)

    Ueno, Osamu; Ishimaru, Ken

    2002-01-01

    The leafless amphibious sedge Eleocharis vivipara develops culms with C(4) traits and Kranz anatomy under terrestrial conditions, but develops culms with C(3) traits and non-Kranz anatomy under submerged conditions. The culms of the terrestrial form have high C(4) enzyme activities, while those of the submerged form have decreased C(4) enzyme activities. The culms accumulate ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) in the mesophyll cells (MC) and the bundle sheath cells. The Rubisco in the MC may be responsible for the operation of the C(3) pathway in the submerged form. To verify the presence of the C(3) cycle in the MC, we examined the effects of 3,3-dichloro-2-(dihydroxyphosphinoylmethyl) -propenoate (DCDP), an inhibitor of phosphoenolpyruvate carboxylase (PEPC), on photosynthesis in culms of the terrestrial forms of E. vivipara and related amphibious species, E. baldwinii and E. retroflexa ssp. chaetaria. When 1 mM DCDP was fed via the transpiration stream to excised leaves, photosynthesis was inhibited completely in Fimbristylis dichotoma (C(4) control), but by only 20% in potato (C(3) control). In the terrestrial Eleocharis plants, the degree of inhibition of photosynthesis by DCDP was intermediate between those of the C(4) and C(3) plants, at 58-81%. These results suggest that photosynthesis under DCDP treatment in the terrestrial Eleocharis plants is due mainly to fixation of atmospheric CO(2) by Rubisco and probably the C(3) cycle in the MC. These features are reminiscent of those in C(4)-like plants. Differential effects of DCDP on photosynthesis of the 3 Eleocharis species are discussed in relation to differences in the degree of Rubisco accumulation and C(3) activity in the MC.

  4. Coprecipitation of M23C6 and MC type carbide under the influence of irradiation

    International Nuclear Information System (INIS)

    Kesternich, W.; Nandedkar, R.V.

    1991-01-01

    After high-temperature neutron irradiation of 1.4970 type steel, M 23 C 6 precipitation was observed in the matrix. This precipitate phase was found only at grain boundaries after thermal treatments. A unique feature of this irradiation-modified phase formation was that the M 23 C 6 precipitates nucleated at the surfaces of pre-existing MC type carbides and grew in a very unusual way by forming facetted enclosures around the primary precipitates. (orig.)

  5. The McDonaldization of Nigerian Universities

    Directory of Open Access Journals (Sweden)

    Emeka W. Dumbili

    2014-04-01

    Full Text Available This article examines the extent to which the deregulation of Nigerian higher education (HE has facilitated the McDonaldization of the universities. University education in Nigeria commenced in 1948 with the establishment of the University College, Ibadan. After independence in 1960, subsequent governments expanded the number of universities, a policy based on a lack of quality manpower in leadership positions created by the exit of British officials and the need to grant access to an increasing number of prospective students. In the 1970s, the number of universities increased accompanied by a decline in infrastructure, funding, and working conditions. This resulted in several strikes and an exodus of academics to other countries. Instead of tackling the problems, the federal government shifted responsibilities by approving private ownership of universities in 1999 and by establishing the National Open University of Nigeria (NOUN in 2001. Against this backdrop, this article critically analyzes how some of these reforms facilitated the McDonaldization of Nigerian universities. The article reveals how this has resulted in an overloading of responsibilities on the faculty, erosion of academic autonomy, a prioritization of quantity over quality of publications, and an assumption of “customer” status by students. The article uses evidence from McDonaldized HE in Western countries to discuss the implications of these developments and suggests some remedial measures.

  6. Application of the McDonald MRI criteria in multiple sclerosis.

    Science.gov (United States)

    Chan, Ling Ling; Sitoh, Yih Yian; Chong, June; See, Siew Ju; Umapathi, Thirugnanam N; Lim, Shih Hui; Ong, Benjamin

    2007-08-01

    The aim of this study was to assess the sensitivity of McDonald's magnetic resonance imaging (MRI) criteria for the diagnosis of multiple sclerosis (MS) in a group of Asian patients diagnosed with clinically definite MS, based on lesion characterisation on MRI scans. Forty-nine patients from 3 major neurological institutions were classified as having Asian- or Western-type MS based on clinical assessment. Each MRI scan was reviewed by 2 neuroradiologists for the presence and characteristics of brain and spinal lesions. The McDonald's MRI criteria were then applied and its sensitivity evaluated. Nine patients were excluded, leaving 34 females and 6 males who were dominantly Chinese (90%), with a mean age of 36.2 years. The MRI brain and spinal findings were detailed and tabulated. Statistically significant differences (P McDonald's MRI criteria were found between our Asian- and Western-type MS patients. The diagnostic yield of McDonald's MRI criteria increased by 20% when we substituted a cord for a brain lesion, and applied the substitution for enhancing cord lesions as well. The diagnosis is more likely to be made when using McDonald MRI criteria based on brain findings, in a patient who presents clinically with Western-type MS. The provision for substitution of "one brain for a spinal lesion" is helpful in Asian-type MS, where there is preponderance of spinal lesion load. Our findings suggest that minor modifications in the interpretation of McDonald's MRI criteria have significant impact on the diagnosis in patients clinically presenting as Asian-type MS, with potential bearing on their subsequent management.

  7. Computation of the locus crossing point location of MC circuit

    International Nuclear Information System (INIS)

    Liu Hai-Jun; Li Zhi-Wei; Bu Kai; Sun Zhao-Lin; Nie Hong-Shan

    2014-01-01

    In this paper, the crossing point property of the i–v hysteresis curve in a memristor–capacitor (MC) circuit is analyzed. First, the ideal passive memristor on the crossing point property of i–v hysteresis curve is studied. Based on the analysis, the analytical derivation with respect to the crossing point location of MC circuit is given. Then the example of MC with linear memristance-versus-charge state map is demonstrated to discuss the drift property of cross-point location, caused by the frequency and capacitance value. (interdisciplinary physics and related areas of science and technology)

  8. McKenzie River Watershed Coordination, Annual Report 2001-2002.

    Energy Technology Data Exchange (ETDEWEB)

    Thrailkil, Jim

    2003-11-01

    BPA funding, in conjunction with contributions from numerous partners organizations and grant funds supports the McKenzie Watershed Council's (MWC) efforts to coordinate restoration and monitoring programs of federal, state, local government, and residents within the watershed. Primary goals of the MWC are to improve resource stewardship and conserve fish, wildlife, and water quality resources. Underpinning the goals is the MWC's baseline program centered on relationship building and information sharing. Objectives for FY02 included: (1) Continue to coordinate McKenzie Watershed activities among diverse groups to restore fish and wildlife habitat in the watershed, with a focus on the middle to lower McKenzie, including private lands and the McKenzie-Willamette confluence area; (2) Influence behavior of watershed residents to benefit watershed function though an outreach and education program, utilizing (BPA funded) Assessment and Conservation Strategy information to provide a context for prioritized action; (3) Continue to maintain and sustain a highly functional watershed council; (4) Maintain and improve water quality concerns through the continuation of Council-sponsored monitoring and evaluation programs; and (5) Continue to secure other funding for watershed restoration and protection projects and Council operations.

  9. Contamination in sediments, bivalves and sponges of McMurdo Sound, Antarctica

    Energy Technology Data Exchange (ETDEWEB)

    Negri, Andrew [Australian Institute of Marine Science, PMB 3, Townsville, Qld (Australia)]. E-mail: a.negri@aims.gov.au; Burns, Kathryn [Australian Institute of Marine Science, PMB 3, Townsville, Qld (Australia); Boyle, Steve [Australian Institute of Marine Science, PMB 3, Townsville, Qld (Australia); Brinkman, Diane [Australian Institute of Marine Science, PMB 3, Townsville, Qld (Australia); Webster, Nicole [Australian Institute of Marine Science, PMB 3, Townsville, Qld (Australia); Biological Sciences, University of Canterbury, Christchurch (New Zealand)

    2006-10-15

    This study examined the concentrations of total hydrocarbons (THC), polychlorinated biphenyls (PCB), polyaromatic hydrocarbons (PAH), and trace metals (Cu, Zn, Cd, Pb, Hg and As) in marine sediments off Scott Base (NZ) and compared them with sediments near the highly polluted McMurdo Station (US) as well as less impacted sites including Turtle Rock and Cape Evans. The Antarctic mollusc, Laternula elliptica and three common sponge species were also analysed for trace metals. The mean THC concentration in sediments from Scott Base was 3 fold higher than the pristine site, Turtle Rock, but 10 fold lower than samples from McMurdo Station. McMurdo Station sediments also contained the highest concentrations of PAHs, PCBs and the trace metals, Cu, Zn, Pb, Cd and Hg. Copper was significantly higher in bivalves from McMurdo Station than other sites. Trace metal concentrations in sponges were generally consistent within sites but no spatial patterns were apparent. - Analyses of Antarctic marine sediments, bivalves and sponges revealed strong PAH, PCB and trace metal gradients in McMurdo Sound.

  10. Contamination in sediments, bivalves and sponges of McMurdo Sound, Antarctica

    International Nuclear Information System (INIS)

    Negri, Andrew; Burns, Kathryn; Boyle, Steve; Brinkman, Diane; Webster, Nicole

    2006-01-01

    This study examined the concentrations of total hydrocarbons (THC), polychlorinated biphenyls (PCB), polyaromatic hydrocarbons (PAH), and trace metals (Cu, Zn, Cd, Pb, Hg and As) in marine sediments off Scott Base (NZ) and compared them with sediments near the highly polluted McMurdo Station (US) as well as less impacted sites including Turtle Rock and Cape Evans. The Antarctic mollusc, Laternula elliptica and three common sponge species were also analysed for trace metals. The mean THC concentration in sediments from Scott Base was 3 fold higher than the pristine site, Turtle Rock, but 10 fold lower than samples from McMurdo Station. McMurdo Station sediments also contained the highest concentrations of PAHs, PCBs and the trace metals, Cu, Zn, Pb, Cd and Hg. Copper was significantly higher in bivalves from McMurdo Station than other sites. Trace metal concentrations in sponges were generally consistent within sites but no spatial patterns were apparent. - Analyses of Antarctic marine sediments, bivalves and sponges revealed strong PAH, PCB and trace metal gradients in McMurdo Sound

  11. Evaluation of ML-MC as a Depth Discriminant in Yellowstone, USA and Italy

    Science.gov (United States)

    Li, Z.; Koper, K. D.; Burlacu, R.; Sun, D.; D'Amico, S.

    2017-12-01

    Recent work has shown that the difference between two magnitude scales, ML (local Richter magnitude) and MC (coda/duration magnitude), acts as a depth discriminant in Utah. Shallow seismic sources, such as mining induced earthquakes and explosions, have strongly negative ML-MC values, while deeper tectonic earthquakes have ML-MC values near zero. These observations imply that ML-MC might be effective at discriminating small explosions from deeper natural earthquakes at local distances. In this work, we examine seismicity catalogs for the Yellowstone region and Italy to determine if ML-MCacts as a depth discriminant in these regions as well. We identified 4,780 earthquakes that occurred in the Yellowstone region between Sept. 24, 1994 and March 31, 2017 for which both ML and MC were calculated. The ML-MC distribution is well described by a Gaussian function with a mean of 0.102 and a standard deviation of 0.326. We selected a subset of these events with accurate depths and determined mean ML-MC values in various depth bins. An event depth was considered accurate if the formal depth error was less than 2 km and either (1) the nearest station was within one focal depth or (2) the distance to the nearest station was smaller than the bin size. We find that ML-MC decreases as event depths become shallower than about 10 km. Similar to the results for Utah, the decrease is statistically significant and is robust with respect to small changes in bin size and the criteria used to define accurate depths. We used a similar process to evaluate whether ML-MC was a function of source depth for 63,555 earthquakes that occurred between April 16, 2005 and April 30, 2012 in Italy. The ML-MC values in Italy are also well described by a normal distribution, with a mean of -0.477 and standard deviation of 0.315. We again find a statistically significant decrease in ML-MC for shallow earthquakes. In contrast to the Yellowstone results, for Italy ML-MC decreases at a nearly constant rate

  12. McKenzie River Subbasin Assessment, Technical Report 2000.

    Energy Technology Data Exchange (ETDEWEB)

    Alsea Geospatial, Inc.

    2000-02-01

    This document details the findings of the McKenzie River Subbasin Assessment team. The goal of the subbasin assessment is to provide an ecological assessment of the McKenzie River Floodplain, identification of conservation and restoration opportunities, and discussion of the influence of some upstream actions and processes. This Technical Report can be viewed in conjunction with the McKenzie River Subbasin Summary or as a stand-alone document. The purpose of the technical report is to detail the methodology and findings of the consulting team that the observations and recommendations in the summary document are based on. This part, Part I, provides an introduction to the subbasin and a general overview. Part II details the specific findings of the science team. Part III provides an explanation and examples of how to use the data that has been developed through this assessment to aid in prioritizing restoration activities. Part III also includes the literature cited and appendices.

  13. McDonald Generalized Linear Failure Rate Distribution

    Directory of Open Access Journals (Sweden)

    Ibrahim Elbatal

    2014-10-01

    Full Text Available We introduce in this paper a new six-parameters generalized version of the generalized linear failure rate (GLFR distribution which is called McDonald Generalized Linear failure rate (McGLFR distribution. The new distribution is quite flexible and can be used effectively in modeling survival data and reliability problems. It can have a constant, decreasing, increasing, and upside down bathtub-and bathtub shaped failure rate function depending on its parameters. It includes some well-known lifetime distributions as special sub-models. Some structural properties of the new distribution are studied. Moreover we discuss maximum likelihood estimation of the unknown parameters of the new model.

  14. SCIENTIFIC PROGRESS OF THE MC-PAD NETWORK

    CERN Document Server

    Aguilar, J; Ambalathankandy, P; Apostolakis, J; Arora, R; Balog, T; Behnke, T; Beltrame, P; Bencivenni, G; Caiazza, S; Dong, J; Heller, M; Heuser, J; Idzik, M; Joram, C; Klanner, R; Koffeman, E; Korpar, S; Kramberger, G; Lohmann, W; Milovanović, M; Miscetti, S; Moll, M; Novgorodova, O; Pacifico, N; Pirvutoiu, C; Radu, R; Rahman, S; Rohe, T; Ropelewski, L; Roukoutakis, F; Schmidt, C; Schön, R; Sibille, J; Tsagri, M; Turala, M; Van Beuzekom, M; Verheyden, R; Villa, M; Zappon, F; Zawiejski, L; Zhang, J

    2013-01-01

    MC-PAD is a multi-site Initial Training Network on particle detectors in physics experiments. It comprises nine academic participants, three industrial partners and two associated academic partners. 17 recruited Early Stage and 5 Experienced Researchers have performed their scientific work in the network. The research and development work of MC-PAD is organized in 12 work packages, which focus on a large variety of aspects of particle detector development, electronics as well as simulation and modelling. The network was established in November 2008 and lasted until October 2012 (48 months). This report describes the R&D activities and highlights the main results achieved during this period.

  15. DANCOFF-MC: A program to calculate Dancoff factors in CANDU type fuel bundles

    Energy Technology Data Exchange (ETDEWEB)

    Feher, S; Valko, J

    1992-12-01

    The objective of DANCOFF-MC is the evaluation of Dancoff factors for cylindrical fuel rods arranged parallel in various and complicated bundle geometries. No interaction with fuel rods in any of the other bundles are considered due to the large distance, in mean free paths, between the buldes. Using a common basic algorithm three versions of the program have been written so far: The DANCOFF-MC-2, the DANCOFF-MC-19 and the DANCOFF-MC-27. (orig./HP).

  16. Dr. David Brown poses with a portrait of Ronald McNair

    Science.gov (United States)

    1999-01-01

    In the gymnasium of Ronald McNair Magnet School in Cocoa, Fla., Dr. David Brown, a NASA astronaut, poses with a portrait of NASA astronaut Ronald McNair. The portrait was presented to the school by Walt Disney World during a tribute to McNair. The school had previously been renamed for the fallen astronaut who was one of a crew of seven who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

  17. On Analyzing LDPC Codes over Multiantenna MC-CDMA System

    Directory of Open Access Journals (Sweden)

    S. Suresh Kumar

    2014-01-01

    Full Text Available Multiantenna multicarrier code-division multiple access (MC-CDMA technique has been attracting much attention for designing future broadband wireless systems. In addition, low-density parity-check (LDPC code, a promising near-optimal error correction code, is also being widely considered in next generation communication systems. In this paper, we propose a simple method to construct a regular quasicyclic low-density parity-check (QC-LDPC code to improve the transmission performance over the precoded MC-CDMA system with limited feedback. Simulation results show that the coding gain of the proposed QC-LDPC codes is larger than that of the Reed-Solomon codes, and the performance of the multiantenna MC-CDMA system can be greatly improved by these QC-LDPC codes when the data rate is high.

  18. Space-Time Coded MC-CDMA: Blind Channel Estimation, Identifiability, and Receiver Design

    Directory of Open Access Journals (Sweden)

    Li Hongbin

    2002-01-01

    Full Text Available Integrating the strengths of multicarrier (MC modulation and code division multiple access (CDMA, MC-CDMA systems are of great interest for future broadband transmissions. This paper considers the problem of channel identification and signal combining/detection schemes for MC-CDMA systems equipped with multiple transmit antennas and space-time (ST coding. In particular, a subspace based blind channel identification algorithm is presented. Identifiability conditions are examined and specified which guarantee unique and perfect (up to a scalar channel estimation when knowledge of the noise subspace is available. Several popular single-user based signal combining schemes, namely the maximum ratio combining (MRC and the equal gain combining (EGC, which are often utilized in conventional single-transmit-antenna based MC-CDMA systems, are extended to the current ST-coded MC-CDMA (STC-MC-CDMA system to perform joint combining and decoding. In addition, a linear multiuser minimum mean-squared error (MMSE detection scheme is also presented, which is shown to outperform the MRC and EGC at some increased computational complexity. Numerical examples are presented to evaluate and compare the proposed channel identification and signal detection/combining techniques.

  19. Comparative Study of McDonald's and Kentucky Fried Chicken (KFC) development in China

    OpenAIRE

    Xie, Yuanyuan; Hu, Wei

    2013-01-01

    Abstract McDonald's and KFC are two international fast food restaurants. They both expended their businesses in global scale. It is obvious that McDonald surpassed KFC in terms of sales and fame in international level. However, in China, KFC performs better than McDonald's. The aim of this study is to find out how these two companies developed differently in Chinese market. By making a comparative study of McDonald's and KFC, different operation and competitive strategy theory will be...

  20. 76 FR 13598 - Notice of Funding Availability: Inviting Applications for McGovern-Dole International Food for...

    Science.gov (United States)

    2011-03-14

    ... Applications for McGovern-Dole International Food for Education and Child Nutrition Program's Micronutrient... the McGovern-Dole International Food for Education and Child Nutrition (McGovern-Dole) Program... through FAS's McGovern-Dole International Food for Education and Child Nutrition (McGovern-Dole) Program...

  1. On the thermodynamics of the McMillan-Mayer state function

    DEFF Research Database (Denmark)

    Mollerup, Jørgen; Breil, Martin Peter

    2009-01-01

    to develop the McMillan-Mayer framework in a classical thermodynamic context for which we develop the relationship between the state function of the McMillan-Mayer framework and the Helmholtz state function. A Taylor expansion method can be applied to the osmotic pressure of a solution which is dilute...

  2. Bridge Suture for Successful McDonald Emergency Cerclage.

    Science.gov (United States)

    Tanaka, Masaaki; Hori, Yoshiaki; Shirafuji, Aya; Kato, Mitsunori; Kato, Jyun; Kobayashi, Hiroto; Tsuchida, Toru; Fukae, Tsukasa

    2017-01-01

    To create awareness about a surgical technique termed bridge suture, which is performed as a pretreatment before a McDonald cerclage is performed on an emergency to treat severe cervical insufficiency. Procedures for bridge suture were reviewed in detail and outcomes of 16 patients treated with bridge suture followed by McDonald cerclage were evaluated retrospectively. Using the bridge suture, the edges of uterine cervix were temporarily sutured and the external uterine os was closed, while the hourglass-shaped fetal membranes were concomitantly confined within the cervix; subsequently, a McDonald cerclage was performed. Over a 22-year period, 16 patients with a dilated cervix and bulging fetal membranes were treated using the technique of bridge suture followed by an emergency cerclage. The mean gestational age at cerclage was 22.5 weeks; the mean gestational age at delivery was 30.7 weeks; and the mean interval between cerclage and delivery was 8.2 weeks. In 15 out of 16 cases, cerclage was performed without encountering any complications. No maternal complications, including cervical laceration, were observed. The mean body weight of 17 neonates, including that of a twin, was 1,516 g and of them, 15 neonates survived. The important outcome of bridge suture is the replacement of fetal membranes back into the uterine cavity before McDonald's cerclage is performed. Pretreatment with bridge suture may facilitate the performance of a successful emergency cerclage and contribute to good maternal and neonatal outcomes. © 2016 S. Karger AG, Basel.

  3. MC rate at NLO for heavy flavour photoproduction at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Toll, Tobias

    2010-02-15

    A Monte Carlo at next-to-leading order (MC rate at NLO) has been constructed for the production of heavy quark flavours in photoproduction. As such, it is the rst Monte Carlo event generator with next-to-leading order (NLO) accuracy for a process in lepton hadron scattering. In order to construct such an MC rate at NLO, the matrix element for the process has to be calculated at NLO and then be matched with a parton shower. When doing this, it is important that none of the parton configurations produced are doubly counted. In this thesis, the concept of a Monte Carlo event generator will be explained, with emphasis on the HERWIG parton shower. Also, different techniques of calculating matrix elements at NLO accuracy will be explained. It will then be shown how the NLO calculation can be matched with the HERWIG parton shower in an MC rate at NLO without double counting, producing unweighted events at NLO-accuracy. Many comparisons are made between the MC rate at NLO here constructed, the HERWIG Monte Carlo and the FMNR NLO calculation. Also many comparisons are made to HERA data from the H1 and ZEUS experiments. It is shown that all HERA data with heavy quarks produced in photoproduction can be described by the MC rate at NLO program constructed in this thesis. (orig.)

  4. MC rate at NLO for heavy flavour photoproduction at HERA

    International Nuclear Information System (INIS)

    Toll, Tobias

    2010-02-01

    A Monte Carlo at next-to-leading order (MC rate at NLO) has been constructed for the production of heavy quark flavours in photoproduction. As such, it is the rst Monte Carlo event generator with next-to-leading order (NLO) accuracy for a process in lepton hadron scattering. In order to construct such an MC rate at NLO, the matrix element for the process has to be calculated at NLO and then be matched with a parton shower. When doing this, it is important that none of the parton configurations produced are doubly counted. In this thesis, the concept of a Monte Carlo event generator will be explained, with emphasis on the HERWIG parton shower. Also, different techniques of calculating matrix elements at NLO accuracy will be explained. It will then be shown how the NLO calculation can be matched with the HERWIG parton shower in an MC rate at NLO without double counting, producing unweighted events at NLO-accuracy. Many comparisons are made between the MC rate at NLO here constructed, the HERWIG Monte Carlo and the FMNR NLO calculation. Also many comparisons are made to HERA data from the H1 and ZEUS experiments. It is shown that all HERA data with heavy quarks produced in photoproduction can be described by the MC rate at NLO program constructed in this thesis. (orig.)

  5. McStas 1.1. A freeware package for neutron Monte Carlo ray-tracing simulations

    International Nuclear Information System (INIS)

    Lefmann, K.; Nielsen, K.

    1999-01-01

    Neutron simulation is becoming an indispensable tool for neutron instrument design. At Risoe National Laboratory, a user-friendly, versatile, and fast simulation package, McStas has been developed, which may be freely downloaded from our website. An instrument is described in the McStas meta-language and is composed of elements from the McStas component library, which is under constant development and debugging by both the users and us. The McStas front- and back-ends take care of performing the simulations and displaying their results, respectively. McStas 1.1 facilities detailed simulations of complicated triple-axis instruments like the Riso RITA spectrometer, and it is equally well equipped for time-of flight spectrometers. At ECNS'99, a brief tutorial of McStas including a few on-line demonstrations is presented. Further, results from the latest simulation work in the growing McStas user group are presented and the future of this project is discussed. (author)

  6. The McDonald Modified Weibull Distribution: Properties and Applications

    OpenAIRE

    Merovci, Faton; Elbatal, Ibrahim

    2013-01-01

    A six parameter distribution so-called the McDonald modified Weibull distribution is defined and studied. The new distribution contains, as special submodels, several important distributions discussed in the literature, such as the beta modified Weibull, Kumaraswamy modified Weibull, McDonald Weibull and modified Weibull distribution,among others. The new distribution can be used effectively in the analysis of survival data since it accommodates monotone, unimodal and bathtub-shaped hazard fu...

  7. McCain, Lieberman ja meie / Marek Strandberg, Indrek Tarand

    Index Scriptorium Estoniae

    Strandberg, Marek, 1965-

    2005-01-01

    USA senaatorite, vabariiklase John McCaini ja demokraat Joe Liebermani poolt USA senati menetlusse antud kahest seaduseelnõust, millest esimene kohustab USA presidenti astuma samme Venemaa ajutiseks väljaheitmiseks rikaste riikide ühendusest G7 ja teine on tuntud kui Climate Stewardship Act ehk kliimahoole seaduseelnõu. Artikli autorid Ilmahoole algatusrühmast kutsuvad üles toetama McCaini-Liebermani initsiatiivi, mis kaitseb ka Eesti välispoliitika huve

  8. CAD-based Monte Carlo program for integrated simulation of nuclear system SuperMC

    International Nuclear Information System (INIS)

    Wu, Yican; Song, Jing; Zheng, Huaqing; Sun, Guangyao; Hao, Lijuan; Long, Pengcheng; Hu, Liqin

    2015-01-01

    Highlights: • The new developed CAD-based Monte Carlo program named SuperMC for integrated simulation of nuclear system makes use of hybrid MC-deterministic method and advanced computer technologies. SuperMC is designed to perform transport calculation of various types of particles, depletion and activation calculation including isotope burn-up, material activation and shutdown dose, and multi-physics coupling calculation including thermo-hydraulics, fuel performance and structural mechanics. The bi-directional automatic conversion between general CAD models and physical settings and calculation models can be well performed. Results and process of simulation can be visualized with dynamical 3D dataset and geometry model. Continuous-energy cross section, burnup, activation, irradiation damage and material data etc. are used to support the multi-process simulation. Advanced cloud computing framework makes the computation and storage extremely intensive simulation more attractive just as a network service to support design optimization and assessment. The modular design and generic interface promotes its flexible manipulation and coupling of external solvers. • The new developed and incorporated advanced methods in SuperMC was introduced including hybrid MC-deterministic transport method, particle physical interaction treatment method, multi-physics coupling calculation method, geometry automatic modeling and processing method, intelligent data analysis and visualization method, elastic cloud computing technology and parallel calculation method. • The functions of SuperMC2.1 integrating automatic modeling, neutron and photon transport calculation, results and process visualization was introduced. It has been validated by using a series of benchmarking cases such as the fusion reactor ITER model and the fast reactor BN-600 model. - Abstract: Monte Carlo (MC) method has distinct advantages to simulate complicated nuclear systems and is envisioned as a routine

  9. Branding McJobs

    DEFF Research Database (Denmark)

    Noppeney, Claus; Endrissat, Nada; Kärreman, Dan

    Traditionally, employer branding has been considered relevant for knowledge intensive firms that compete in a ‘war for talent’. However, the continuous rise in service sector jobs and the negative image of these so-called McJobs has motivated a trend in rebranding service work. Building on critical...... oriented branding literature, our contribution to this stream of research is twofold: We provide an empirical account of employer branding of a grocery chain, which has repeatedly been voted among the ‘100 best companies to work for’. Second, we outline the role of symbolic compensation that employees...... of employer branding....

  10. Autoradiographic imaging of the serotonin transporter, using S-[{sup 18}F](fluoromethyl)-(+)-McN5652 ([{sup 18}F]Me-McN) in the brains of several animal species

    Energy Technology Data Exchange (ETDEWEB)

    Kretzschmar, M.; Zessin, J.; Brust, P.; Cumming, P. [PET Centre of Aarhus Univ. Hospitals, Aarhus C (Denmark); Bergmann, R.

    2002-01-01

    The [{sup 18}F]fluoromethyl analogue of (+)-McN5652 ([{sup 18}F]Me-McN) was recently proposed as a new potential PET tracer [1]. To further validate its use in PET, we studied the binding of [{sup 18}F]Me-McN in the brains of rats and pigs using autoradiography. The binding was compared with the uptake of the known 5-HT uptake inhibitor [{sup 3}H] citalopram [2] and the radioligand (+)-[{sup 11}C]McN5652. The binding of the three compounds was qualitatively identical in the autoradiograms of the individual brains. Intense labelling was observed in regions known to be serotonin uptake sites. The binding was specifically inhibited, using the 5-HT uptake inhibitors citalopram and fluoxetine. (orig.)

  11. Monte Carlo dose calculation improvements for low energy electron beams using eMC

    International Nuclear Information System (INIS)

    Fix, Michael K; Frei, Daniel; Volken, Werner; Born, Ernst J; Manser, Peter; Neuenschwander, Hans

    2010-01-01

    The electron Monte Carlo (eMC) dose calculation algorithm in Eclipse (Varian Medical Systems) is based on the macro MC method and is able to predict dose distributions for high energy electron beams with high accuracy. However, there are limitations for low energy electron beams. This work aims to improve the accuracy of the dose calculation using eMC for 4 and 6 MeV electron beams of Varian linear accelerators. Improvements implemented into the eMC include (1) improved determination of the initial electron energy spectrum by increased resolution of mono-energetic depth dose curves used during beam configuration; (2) inclusion of all the scrapers of the applicator in the beam model; (3) reduction of the maximum size of the sphere to be selected within the macro MC transport when the energy of the incident electron is below certain thresholds. The impact of these changes in eMC is investigated by comparing calculated dose distributions for 4 and 6 MeV electron beams at source to surface distance (SSD) of 100 and 110 cm with applicators ranging from 6 x 6 to 25 x 25 cm 2 of a Varian Clinac 2300C/D with the corresponding measurements. Dose differences between calculated and measured absolute depth dose curves are reduced from 6% to less than 1.5% for both energies and all applicators considered at SSD of 100 cm. Using the original eMC implementation, absolute dose profiles at depths of 1 cm, d max and R50 in water lead to dose differences of up to 8% for applicators larger than 15 x 15 cm 2 at SSD 100 cm. Those differences are now reduced to less than 2% for all dose profiles investigated when the improved version of eMC is used. At SSD of 110 cm the dose difference for the original eMC version is even more pronounced and can be larger than 10%. Those differences are reduced to within 2% or 2 mm with the improved version of eMC. In this work several enhancements were made in the eMC algorithm leading to significant improvements in the accuracy of the dose calculation

  12. Monte Carlo dose calculation improvements for low energy electron beams using eMC.

    Science.gov (United States)

    Fix, Michael K; Frei, Daniel; Volken, Werner; Neuenschwander, Hans; Born, Ernst J; Manser, Peter

    2010-08-21

    The electron Monte Carlo (eMC) dose calculation algorithm in Eclipse (Varian Medical Systems) is based on the macro MC method and is able to predict dose distributions for high energy electron beams with high accuracy. However, there are limitations for low energy electron beams. This work aims to improve the accuracy of the dose calculation using eMC for 4 and 6 MeV electron beams of Varian linear accelerators. Improvements implemented into the eMC include (1) improved determination of the initial electron energy spectrum by increased resolution of mono-energetic depth dose curves used during beam configuration; (2) inclusion of all the scrapers of the applicator in the beam model; (3) reduction of the maximum size of the sphere to be selected within the macro MC transport when the energy of the incident electron is below certain thresholds. The impact of these changes in eMC is investigated by comparing calculated dose distributions for 4 and 6 MeV electron beams at source to surface distance (SSD) of 100 and 110 cm with applicators ranging from 6 x 6 to 25 x 25 cm(2) of a Varian Clinac 2300C/D with the corresponding measurements. Dose differences between calculated and measured absolute depth dose curves are reduced from 6% to less than 1.5% for both energies and all applicators considered at SSD of 100 cm. Using the original eMC implementation, absolute dose profiles at depths of 1 cm, d(max) and R50 in water lead to dose differences of up to 8% for applicators larger than 15 x 15 cm(2) at SSD 100 cm. Those differences are now reduced to less than 2% for all dose profiles investigated when the improved version of eMC is used. At SSD of 110 cm the dose difference for the original eMC version is even more pronounced and can be larger than 10%. Those differences are reduced to within 2% or 2 mm with the improved version of eMC. In this work several enhancements were made in the eMC algorithm leading to significant improvements in the accuracy of the dose

  13. mc1r Pathway regulation of zebrafish melanosome dispersion

    DEFF Research Database (Denmark)

    Richardson, Jennifer; Lundegaard, Pia Rengtved; Reynolds, Natalie L

    2008-01-01

    Zebrafish rapidly alter their pigmentation in response to environmental changes. For black melanocytes, this change is due to aggregation or dispersion of melanin in the cell. Dispersion and aggregation are controlled by intracellular cyclic adenosine monophosphate (cAMP) levels, which increase...... in mammals, and melanosome dispersal in cold-blood vertebrates, the pathway components are highly conserved. However, it has only been assumed that mc1r mediates melanosome dispersal in fish. Here, using morpholino oligonucleotides designed to knockdown mc1r expression, we find that mc1r morphants are unable...... to disperse melanosomes when grown in dark conditions. We also use chemical modifiers of the cAMP pathway, and find an unexpected response to the specific phosphodiesterase 4 (PDE4) inhibitor, rolipram, in melanosome dispersal. When treated with the drug, melanosomes fail to fully disperse in dark conditions...

  14. McDonald's Recipe for Success

    Science.gov (United States)

    Weinstein, Margery

    2012-01-01

    Who isn't familiar with McDonald's? Its golden arches are among the most recognizable brand icons in the U.S. What many are less familiar with is the methodical and distinguished learning and development that supports that brand. Training that begins by preparing employees to serve customers at the counter, and extends to programs that help…

  15. Disposition and pharmacokinetics in rats of McN-5707, a potential antidepressant drug

    International Nuclear Information System (INIS)

    Ng, K.T.; Holland, M.L.; Hills, J.F.; Uetz, J.A.

    1986-01-01

    A single 80 mg/kg oral solution dose of McN-5707- 14 C x HBr [trans-6-(2-chlorophenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline hydrobromide (1:1)] was administered orally to 40 Wistar rats. Total 14 C concentrations in plasma were high (> 4.5 μg x equiv/mL) for at least 24 hours after dosing. Unchanged McN-5707 represented 14 C concs in plasma at 45 min and < 1% at 24 hours after dosing. In the 8 days following dose administration, 23% of the dose was excreted in urine and 70% of the dose was excreted in feces. Analysis (HPLC and TLC) of glusulase treated urine, plasma and fecal samples revealed the presence of multiple metabolites of McN-5707. Unchanged McN-5707 was found only in fecal extracts (2-7% of dose). Single solution doses of McN-5707 x HBr were administered p.o. (20 mg/kg) and i.v. (4 mg/kg) to 39 Wistar rats. Plasma samples were analyzed for McN-5707 using a capillary GC assay. These studies indicated that McN-5707 was well absorbed and extensively metabolized in rats following oral doses

  16. Application of ground-penetrating radar at McMurdo Station, Antarctica

    Energy Technology Data Exchange (ETDEWEB)

    Stefano, J.E.

    1992-01-01

    Argonne National Laboratory initiated a site investigation program at McMurdo Station, Antarctica, to characterize environmental contamination. The performance and usefulness of ground-penetrating radar (GPR) was evaluated under antarctic conditions during the initial site investigation in January 1991. Preliminary surveys were successful in defining the contact between reworked pyroclastic material and in the prefill, undisturbed pyroclastics and basalts at some sites. Interference from radio traffic at McMurdo Station was not observed, but interference was a problem in work with unshielded antennas near buildings. In general, the results of this field test suggest that high-quality, high-resolution, continuous subsurface profiles can be produced with GPR over most of McMurdo Station.

  17. Application of ground-penetrating radar at McMurdo Station, Antarctica

    Energy Technology Data Exchange (ETDEWEB)

    Stefano, J.E.

    1992-05-01

    Argonne National Laboratory initiated a site investigation program at McMurdo Station, Antarctica, to characterize environmental contamination. The performance and usefulness of ground-penetrating radar (GPR) was evaluated under antarctic conditions during the initial site investigation in January 1991. Preliminary surveys were successful in defining the contact between reworked pyroclastic material and in the prefill, undisturbed pyroclastics and basalts at some sites. Interference from radio traffic at McMurdo Station was not observed, but interference was a problem in work with unshielded antennas near buildings. In general, the results of this field test suggest that high-quality, high-resolution, continuous subsurface profiles can be produced with GPR over most of McMurdo Station.

  18. Application of ground-penetrating radar at McMurdo Station, Antarctica

    International Nuclear Information System (INIS)

    Stefano, J.E.

    1992-01-01

    Argonne National Laboratory initiated a site investigation program at McMurdo Station, Antarctica, to characterize environmental contamination. The performance and usefulness of ground-penetrating radar (GPR) was evaluated under antarctic conditions during the initial site investigation in January 1991. Preliminary surveys were successful in defining the contact between reworked pyroclastic material and in the prefill, undisturbed pyroclastics and basalts at some sites. Interference from radio traffic at McMurdo Station was not observed, but interference was a problem in work with unshielded antennas near buildings. In general, the results of this field test suggest that high-quality, high-resolution, continuous subsurface profiles can be produced with GPR over most of McMurdo Station

  19. Remediation System Evaluation, McCormick and Baxter Superfund SiteRemediation System Evaluation, McCormick and Baxter Superfund Site

    Science.gov (United States)

    The McCormick and Baxter Creosoting Company, Portland Plant, Superfund Site is located adjacent tothe Willamette River in Portland, Oregon and addresses contamination of soil, groundwater, and riversediments stemming from creosoting operations...

  20. Evidence that multiple genetic variants of MC4R play a functional role in the regulation of energy expenditure and appetite in Hispanic children1234

    Science.gov (United States)

    Cole, Shelley A; Voruganti, V Saroja; Cai, Guowen; Haack, Karin; Kent, Jack W; Blangero, John; Comuzzie, Anthony G; McPherson, John D; Gibbs, Richard A

    2010-01-01

    Background: Melanocortin-4-receptor (MC4R) haploinsufficiency is the most common form of monogenic obesity; however, the frequency of MC4R variants and their functional effects in general populations remain uncertain. Objective: The aim was to identify and characterize the effects of MC4R variants in Hispanic children. Design: MC4R was resequenced in 376 parents, and the identified single nucleotide polymorphisms (SNPs) were genotyped in 613 parents and 1016 children from the Viva la Familia cohort. Measured genotype analysis (MGA) tested associations between SNPs and phenotypes. Bayesian quantitative trait nucleotide (BQTN) analysis was used to infer the most likely functional polymorphisms influencing obesity-related traits. Results: Seven rare SNPs in coding and 18 SNPs in flanking regions of MC4R were identified. MGA showed suggestive associations between MC4R variants and body size, adiposity, glucose, insulin, leptin, ghrelin, energy expenditure, physical activity, and food intake. BQTN analysis identified SNP 1704 in a predicted micro-RNA target sequence in the downstream flanking region of MC4R as a strong, probable functional variant influencing total, sedentary, and moderate activities with posterior probabilities of 1.0. SNP 2132 was identified as a variant with a high probability (1.0) of exerting a functional effect on total energy expenditure and sleeping metabolic rate. SNP rs34114122 was selected as having likely functional effects on the appetite hormone ghrelin, with a posterior probability of 0.81. Conclusion: This comprehensive investigation provides strong evidence that MC4R genetic variants are likely to play a functional role in the regulation of weight, not only through energy intake but through energy expenditure. PMID:19889825

  1. Detrital U-Pb zircon analysis of an Eocene McMurdo Erratic sandstone, McMurdo Sound, Antarctica

    International Nuclear Information System (INIS)

    Paulsen, T.; Encarnacion, J.; Valencia, V.A.; Roti Roti, J.M.; Rasoazanamparany, C.

    2011-01-01

    Some of the most important Cenozoic sedimentary rocks in Antarctica are glacial erratics of fossiliferous Palaeogene to Neogene siliclastic rocks known as the McMurdo Erratics. Detrital zircon U-Pb isotopic data reported herein provide new information on the provenance of these siliciclastic rocks. The U-Pb age data from a sandstone glacial erratic that is likely of Eocene age show a dominant age cluster that ranges from 488 to 635 Ma, accompanied by subsidiary Neoproterozoic-Archaean peaks. The dominant Neoproterozoic-Ordovician age cluster, in conjunction with the arkosic lithologies of some erratics and the local presence of granitic and metasedimentary clasts, indicates that the Neoproterozoic-Ordovician basement complex of the Transantarctic Mountains likely served as a major source for the Eocene siliciclastic sediments. This is consistent with derivation of the McMurdo Erratics from locations proximal to the Transantarctic Mountains such as the Discovery Deep and/or major mountain outlet glacier areas. (author). 19 refs., 3 figs., 1 tab.

  2. CAD-based Monte Carlo program for integrated simulation of nuclear system SuperMC

    International Nuclear Information System (INIS)

    Wu, Y.; Song, J.; Zheng, H.; Sun, G.; Hao, L.; Long, P.; Hu, L.

    2013-01-01

    SuperMC is a (Computer-Aided-Design) CAD-based Monte Carlo (MC) program for integrated simulation of nuclear systems developed by FDS Team (China), making use of hybrid MC-deterministic method and advanced computer technologies. The design aim, architecture and main methodology of SuperMC are presented in this paper. The taking into account of multi-physics processes and the use of advanced computer technologies such as automatic geometry modeling, intelligent data analysis and visualization, high performance parallel computing and cloud computing, contribute to the efficiency of the code. SuperMC2.1, the latest version of the code for neutron, photon and coupled neutron and photon transport calculation, has been developed and validated by using a series of benchmarking cases such as the fusion reactor ITER model and the fast reactor BN-600 model

  3. A new approach to the d-MC problem

    International Nuclear Information System (INIS)

    Yeh, W.-C.

    2002-01-01

    Many real-world systems are multi-state systems composed of multi-state components in which the reliability can be computed in terms of the lower bound points of level d, called d-Mincuts (d-MCs). Such systems (electric power, transportation, etc.) may be regarded as flow networks whose arcs have independent, discrete, limited and multi-valued random capacities. In this paper, all MCs are assumed to be known in advance, and we focused on how to verify each d-MC candidate before using d-MCs to calculate the network reliability. The proposed algorithm is more efficient than existing algorithms. The algorithm runs in O(pσmn) time, a significant improvement over the previous O(pσm 2 ) time bounds based on max-flow/min-cut, where p and σ are the number of MCs and d-MC candidates, respectively. It is simple, intuitive and uses no complex data structures. An example is given to show how all d-MC candidates are found and verified by the proposed algorithm. Then the reliability of this example is computed

  4. Association between MC4R rs17782313 polymorphism and overeating behaviors.

    Science.gov (United States)

    Yilmaz, Z; Davis, C; Loxton, N J; Kaplan, A S; Levitan, R D; Carter, J C; Kennedy, J L

    2015-01-01

    Melanocortins have a crucial role in appetite and weight regulation. Although the melanocortin 4 receptor (MC4R) gene has been repeatedly linked to obesity and antipsychotic-induced weight gain, the mechanism behind how it leads to this effect in still undetermined. The goal of this study was to conduct an in-depth and sophisticated analysis of MC4R polymorphisms, body mass index (BMI), eating behavior and depressed mood. We genotyped 328 individuals of European ancestry on the following MC4R markers based on the relevant literature on obesity and antipsychotic-induced weight gain: rs571312, rs17782313, rs489693, rs11872992, and rs8087522. Height and weight were measured, and information on depressed mood and overeating behaviors was obtained during the in-person assessment. BMI was associated with rs17782313 C allele; however, this finding did not survive correction for multiple testing (P = 0.018). Although rs17782313 was significantly associated with depressed mood and overeating behaviors, tests of indirect effects indicated that emotional eating and food cravings, rather than depressed mood, uniquely accounted for the effect of this marker and BMI (n = 152). To our knowledge, this is the first study to investigate the link between MC4R rs17782313, mood and overeating behavior, as well as to demonstrate possible mechanisms behind MC4R's influence on body weight. If replicated in a larger sample, these results may have important clinical implications, including potential for the use of MC4R agonists in the treatment of obesity and disordered eating.

  5. Glocalization Marketing Strategy of Mc Donald's Case Study: Turkey

    OpenAIRE

    Kolmakova, Liubov

    2017-01-01

    Globalization is spreading worldwide and it is coming together with its norms. These norms are not appreciated worldwide and there are many nations which have significant populations that are opposed to globalization and its norms. Mc Donald’s is a multinational corporation, it is entering and expanding into different markets as a result of globalization. Nevertheless, this should not indicate that it is an easy goal to spread worldwide for Mc Donald’s due to the anti-globalization movements....

  6. MC++ and a transport physics framework

    International Nuclear Information System (INIS)

    Lee, S.R.; Cummings, J.C.; Nolen, S.D.; Keen, N.D.

    1997-01-01

    The Department of Energy has launched the Accelerated Strategic Computing Initiative (ASCI) to address a pressing need for more comprehensive computer simulation capabilities in the area of nuclear weapons safety and reliability. In light of the decision by the US Government to abandon underground nuclear testing, the Science-Based Stockpile Stewardship (SBSS) program is focused on using computer modeling to assure the continued safety and effectiveness of the nuclear stockpile. The authors believe that the utilization of object-oriented design and programming techniques can help in this regard. Object-oriented programming (OOP) has become a popular model in the general software community for several reasons. MC++ is a specific ASCI-relevant application project which demonstrates the effectiveness of the object-oriented approach. It is a Monte Carlo neutron transport code written in C++. It is designed to be simple yet flexible, with the ability to quickly introduce new numerical algorithms or representations of the physics into the code. MC++ is easily ported to various types of Unix workstations and parallel computers such as the three new ASCI platforms, largely because it makes extensive use of classes from the Parallel Object-Oriented Methods and Applications (POOMA) C++ class library. The MC++ code has been successfully benchmarked using some simple physics test problems, has been shown to provide comparable serial performance and a parallel efficiency superior to that of a well-known Monte Carlo neutronics package written in Fortran, and was the first ASCI-relevant application to run in parallel on all three ASCI computing platforms

  7. New features in McStas, version 1.5

    DEFF Research Database (Denmark)

    Åstrand, P.O.; Lefmann, K.; Farhi, E.

    2002-01-01

    The neutron ray-tracing simulation package McStas has attracted numerous users, and the development of the package continues with version 1.5 released at the ICNS 2001 conference. New features include: support for neutron polarisation, labelling of neutrons, realistic source and sample components......, and interface to the Riso instrument-control software TASCOM. We give a general introduction to McStas and present the latest developments. In particular, we give an example of how the neutron-label option has been used to locate the origin of a spurious side-peak, observed in an experiment with RITA-1 at Riso....

  8. Brown-McLean Syndrome in a Pediatric Patient

    Science.gov (United States)

    Tourkmani, Abdo Karim; Martinez, Jaime D.; Berrones, David; Juárez-Domínguez, Brenda Y.; Beltrán, Francisco; Galor, Anat

    2015-01-01

    The purpose of this manuscript is to report the case of a 12-year-old patient who presented for routine ophthalmic examination after congenital cataract surgery performed at 2 months of age. The patient was diagnosed with bilateral Brown-McLean syndrome by slit lamp examination. No treatment was required because the patient was asymptomatic and had a clear central cornea. This is the first described case of Brown-McLean syndrome in a pediatric patient, representing the importance of clinical examination in the pediatric age group after cataract surgery because of the risk for patients of developing peripheral edema. PMID:26034485

  9. New features in McStas, version 1.5

    International Nuclear Information System (INIS)

    Aastrand, P.O.; Lefmann, K.; Nielsen, K.; Skaarup, P.; Farhi, E.

    2002-01-01

    The neutron ray-tracing simulation package McStas has attracted numerous users, and the development of the package continues with version 1.5 released at the ICNS 2001 conference. New features include: support for neutron polarisation, labelling of neutrons, realistic source and sample components, and interface to the Riso instrument-control software TASCOM. We give a general introduction to McStas and present the latest developments. In particular, we give an example of how the neutron-label option has been used to locate the origin of a spurious side-peak, observed in an experiment with RITA-1 at Riso. (orig.)

  10. A GPU OpenCL based cross-platform Monte Carlo dose calculation engine (goMC)

    Science.gov (United States)

    Tian, Zhen; Shi, Feng; Folkerts, Michael; Qin, Nan; Jiang, Steve B.; Jia, Xun

    2015-09-01

    Monte Carlo (MC) simulation has been recognized as the most accurate dose calculation method for radiotherapy. However, the extremely long computation time impedes its clinical application. Recently, a lot of effort has been made to realize fast MC dose calculation on graphic processing units (GPUs). However, most of the GPU-based MC dose engines have been developed under NVidia’s CUDA environment. This limits the code portability to other platforms, hindering the introduction of GPU-based MC simulations to clinical practice. The objective of this paper is to develop a GPU OpenCL based cross-platform MC dose engine named goMC with coupled photon-electron simulation for external photon and electron radiotherapy in the MeV energy range. Compared to our previously developed GPU-based MC code named gDPM (Jia et al 2012 Phys. Med. Biol. 57 7783-97), goMC has two major differences. First, it was developed under the OpenCL environment for high code portability and hence could be run not only on different GPU cards but also on CPU platforms. Second, we adopted the electron transport model used in EGSnrc MC package and PENELOPE’s random hinge method in our new dose engine, instead of the dose planning method employed in gDPM. Dose distributions were calculated for a 15 MeV electron beam and a 6 MV photon beam in a homogenous water phantom, a water-bone-lung-water slab phantom and a half-slab phantom. Satisfactory agreement between the two MC dose engines goMC and gDPM was observed in all cases. The average dose differences in the regions that received a dose higher than 10% of the maximum dose were 0.48-0.53% for the electron beam cases and 0.15-0.17% for the photon beam cases. In terms of efficiency, goMC was ~4-16% slower than gDPM when running on the same NVidia TITAN card for all the cases we tested, due to both the different electron transport models and the different development environments. The code portability of our new dose engine goMC was validated by

  11. A GPU OpenCL based cross-platform Monte Carlo dose calculation engine (goMC).

    Science.gov (United States)

    Tian, Zhen; Shi, Feng; Folkerts, Michael; Qin, Nan; Jiang, Steve B; Jia, Xun

    2015-10-07

    Monte Carlo (MC) simulation has been recognized as the most accurate dose calculation method for radiotherapy. However, the extremely long computation time impedes its clinical application. Recently, a lot of effort has been made to realize fast MC dose calculation on graphic processing units (GPUs). However, most of the GPU-based MC dose engines have been developed under NVidia's CUDA environment. This limits the code portability to other platforms, hindering the introduction of GPU-based MC simulations to clinical practice. The objective of this paper is to develop a GPU OpenCL based cross-platform MC dose engine named goMC with coupled photon-electron simulation for external photon and electron radiotherapy in the MeV energy range. Compared to our previously developed GPU-based MC code named gDPM (Jia et al 2012 Phys. Med. Biol. 57 7783-97), goMC has two major differences. First, it was developed under the OpenCL environment for high code portability and hence could be run not only on different GPU cards but also on CPU platforms. Second, we adopted the electron transport model used in EGSnrc MC package and PENELOPE's random hinge method in our new dose engine, instead of the dose planning method employed in gDPM. Dose distributions were calculated for a 15 MeV electron beam and a 6 MV photon beam in a homogenous water phantom, a water-bone-lung-water slab phantom and a half-slab phantom. Satisfactory agreement between the two MC dose engines goMC and gDPM was observed in all cases. The average dose differences in the regions that received a dose higher than 10% of the maximum dose were 0.48-0.53% for the electron beam cases and 0.15-0.17% for the photon beam cases. In terms of efficiency, goMC was ~4-16% slower than gDPM when running on the same NVidia TITAN card for all the cases we tested, due to both the different electron transport models and the different development environments. The code portability of our new dose engine goMC was validated by

  12. A GPU OpenCL based cross-platform Monte Carlo dose calculation engine (goMC)

    International Nuclear Information System (INIS)

    Tian, Zhen; Shi, Feng; Folkerts, Michael; Qin, Nan; Jiang, Steve B; Jia, Xun

    2015-01-01

    Monte Carlo (MC) simulation has been recognized as the most accurate dose calculation method for radiotherapy. However, the extremely long computation time impedes its clinical application. Recently, a lot of effort has been made to realize fast MC dose calculation on graphic processing units (GPUs). However, most of the GPU-based MC dose engines have been developed under NVidia’s CUDA environment. This limits the code portability to other platforms, hindering the introduction of GPU-based MC simulations to clinical practice. The objective of this paper is to develop a GPU OpenCL based cross-platform MC dose engine named goMC with coupled photon–electron simulation for external photon and electron radiotherapy in the MeV energy range. Compared to our previously developed GPU-based MC code named gDPM (Jia et al 2012 Phys. Med. Biol. 57 7783–97), goMC has two major differences. First, it was developed under the OpenCL environment for high code portability and hence could be run not only on different GPU cards but also on CPU platforms. Second, we adopted the electron transport model used in EGSnrc MC package and PENELOPE’s random hinge method in our new dose engine, instead of the dose planning method employed in gDPM. Dose distributions were calculated for a 15 MeV electron beam and a 6 MV photon beam in a homogenous water phantom, a water-bone-lung-water slab phantom and a half-slab phantom. Satisfactory agreement between the two MC dose engines goMC and gDPM was observed in all cases. The average dose differences in the regions that received a dose higher than 10% of the maximum dose were 0.48–0.53% for the electron beam cases and 0.15–0.17% for the photon beam cases. In terms of efficiency, goMC was ∼4–16% slower than gDPM when running on the same NVidia TITAN card for all the cases we tested, due to both the different electron transport models and the different development environments. The code portability of our new dose engine goMC was

  13. Vnímanie značky McDonald's na českom trhu

    OpenAIRE

    Harčár, Tomáš

    2015-01-01

    The bachelor thesis explores perception of the brand McDonald's on the Czech market. The objective of this thesis is to test via questionnaire an assumption, which is based on belief that customers find food sold in McDonald's restaurant unhealthy and of poor quality. The thesis contains a theoretic part which presents a basic definition linked to brand building and brand image. Those definitions are further used to explain advertising strategy of McDonald's company. Concluding chapter evalua...

  14. GPM GROUND VALIDATION OKLAHOMA CLIMATOLOGICAL SURVEY MESONET MC3E V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The GPM Ground Validation Oklahoma Climatological Survey Mesonet MC3E data were collected during the Midlatitude Continental Convective Clouds Experiment (MC3E) in...

  15. Ronald McDonald dit: "Tout le monde connait: 'Deuxsteakshachessaucespecialesaladefromageoignons dansuntriplepainrondrecouvertdegrainsdesesames'" (Ronald McDonald Says: "Everyone Knows: 'Two-All-Beef-Patties-Special-Sauce-Lettuce-Cheese-Pickles- Onions-on-a-Sesame-Seed Bun'").

    Science.gov (United States)

    Headrick, Robert J., Jr.

    This booklet is intended for classroom use in first-year high school French to acquaint students with the McDonald's fast food restaurants in Paris. The specific objectives are for the student to: (1) discuss the similarities and differences between the American and Parisian McDonald's, (2) set up a miniature McDonald's in the classroom, (3) order…

  16. Evaluation of MC and A detection time

    International Nuclear Information System (INIS)

    Smith, B.W.; Thomas, N.M.

    1984-07-01

    The US Nuclear Regulatory Commission has proposed reform of the material control and accounting (MC and A) requirements for facilities authorized to possess and use formula quantities of strategic special nuclear material (SSNM). The purpose of the reform is to strengthen MC and A capabilities by requiring more timely detection of possible SSNM losses and by providing for more rapid and conclusive resolution of discrepancies. This study was conducted to identify the advantages and disadvantages of detection time intervals ranging from one day to two weeks. Material loss tests based on existing process monitoring data are used to compare the detection sensitiviy, alarm frequency, resolution capability and effort to collect and process data for the stipulated range of detection times. 15 references, 4 figures, 12 tables

  17. Late diagnosis of a McFarland fracture: imaging and treatment

    Energy Technology Data Exchange (ETDEWEB)

    Symeonidis, Panagiotis D. [Aristotelian University of Thessaloniki, Thessaloniki (Greece); Konstantinidis, George Ath; Givisis, Panagiotis G. [Aristotelian University of Thessaloniki, Thessaloniki (Greece); Dionellis, Panagiotis S. [Hippocration General Hospital of Thessaloniki, Thessaloniki (Greece); Ousatzopoulos, John [Private Practice Thessaloniki, Thessaloniki (Greece)

    2014-01-15

    McFarland fractures represent a type of oblique medial malleolar fracture in children that can be challenging to diagnose and treat. A 14-year-old junior league soccer player with a Salter Harris type IV McFarland fracture presented late, as the initial routine two views radiological assessment failed to reveal a clear fracture line. The addition of a mortise ankle view led to the correct diagnosis and subsequent MRI findings guided nonsurgical treatment with an excellent outcome. The debate between obtaining two or three views in closed pediatric ankle injuries according to the so-called Ottawa rules and the usefulness of magnetic resonance imaging (MRI) in the decision making for the choice of treatment of McFarland fractures are discussed in this case report. (orig.)

  18. Late diagnosis of a McFarland fracture: imaging and treatment

    International Nuclear Information System (INIS)

    Symeonidis, Panagiotis D.; Konstantinidis, George Ath; Givisis, Panagiotis G.; Dionellis, Panagiotis S.; Ousatzopoulos, John

    2014-01-01

    McFarland fractures represent a type of oblique medial malleolar fracture in children that can be challenging to diagnose and treat. A 14-year-old junior league soccer player with a Salter Harris type IV McFarland fracture presented late, as the initial routine two views radiological assessment failed to reveal a clear fracture line. The addition of a mortise ankle view led to the correct diagnosis and subsequent MRI findings guided nonsurgical treatment with an excellent outcome. The debate between obtaining two or three views in closed pediatric ankle injuries according to the so-called Ottawa rules and the usefulness of magnetic resonance imaging (MRI) in the decision making for the choice of treatment of McFarland fractures are discussed in this case report. (orig.)

  19. Spectrum and Structure of Spiropyran

    National Research Council Canada - National Science Library

    Young, J

    1994-01-01

    .... Both quantum mechanical and classical methods were used. Irradiation of spiropyran by UV light causes molecular rearrangement, thus yielding merocyanine whose absorption band lies in the visible region...

  20. Kinetics of growth of Leishmania (Leishmania chagasi cycle in McCoy cell culture Cinéticas de crescimento do ciclo da Leishmania (Leishmania chagasi em cultura de células McCoy

    Directory of Open Access Journals (Sweden)

    Yeda L. Nogueira

    2006-12-01

    Full Text Available The kinetics of growth of Leishmania performed in vitro after internalization of the promastigote form in the cell and the occurrence of the transformation of the parasite into the amastigote form have been described by several authors. They used explants of macrophages in hamster spleen cell culture or in a human macrophage lineage cell, the U937. Using microscopy, the description of morphologic inter-relationship and the analysis of the production of specific molecules, it has been possible to define some of the peculiarities of the biology of the parasite. The present study shows the growth cycle of Leishmania chagasi during the observation of kinetic analysis undertaken with a McCoy cell lineage that lasted for a period of 144 hours. During the process, the morphologic transformation was revealed by indirect immunofluorescence (IF and the molecules liberated in the extra cellular medium were observed by SDS-PAGE at 24-hour intervals during the whole 144-hour period. It was observed that in the first 72 hours the promastigote form of L. chagasi adhered to the cell membranes and assumed a rounded (amastigote-like form. At 96 hours the infected cells showed morphologic alterations; at 120 hours the cells had liberated soluble fluorescent antigens into the extra cellular medium. At 144 hours, new elongated forms of the parasites, similar to promastigotes, were observed. In the SDS-PAGE, specific molecular weight proteins were observed at each point of the kinetic analysis showing that the McCoy cell imitates the macrophage and may be considered a useful model for the study of the infection of the Leishmania/cell binomial.Cinéticas de crescimento de Leishmania realizadas in vitro após a internalização da forma promastigota na célula e a ocorrência da transformação do parasito na forma amastigota foram descritas por vários autores, seja com a utilização de explantes de macrófagos em células de baço de hamster ou atualmente da c

  1. CTUIR Grande Ronde River Watershed Restoration Program McCoy Creek/McIntyre Creek Road Crossing, 1995-1999 Progress Report.

    Energy Technology Data Exchange (ETDEWEB)

    Childs, Allen B.

    2000-08-01

    The Confederated Tribes of the Umatilla Indian Reservation (CTUIR) and Bonneville Power Administration (BPA) entered into a contract agreement beginning in 1996 to fund watershed restoration and enhancement actions and contribute to recovery of fish and wildlife resources and water quality in the Grande Ronde River Basin. The CTUIR's habitat program is closely coordinated with the Grande Ronde Model Watershed Program and multiple agencies and organizations within the basin. The CTUIR has focused during the past 4 years in the upper portions of the Grande Ronde Subbasin (upstream of LaGrande, Oregon) on several major project areas in the Meadow, McCoy, and McIntyre Creek watersheds and along the mainstem Grande Ronde River. This Annual Report provides an overview of individual projects and accomplishments.

  2. McRunjob: A High Energy Physics Workflow Planner for Grid Production Processing

    OpenAIRE

    Graham, G E; Evans, D; Bertram, I

    2003-01-01

    McRunjob is a powerful grid workflow manager used to manage the generation of large numbers of production processing jobs in High Energy Physics. In use at both the DZero and CMS experiments, McRunjob has been used to manage large Monte Carlo production processing since 1999 and is being extended to uses in regular production processing for analysis and reconstruction. Described at CHEP 2001, McRunjob converts core metadata into jobs submittable in a variety of environments. The powerful core...

  3. Physical training for McArdle disease

    DEFF Research Database (Denmark)

    Quinlivan, Rosaline; Vissing, John; Hilton-Jones, David

    2011-01-01

    McArdle disease is a rare metabolic myopathy caused by a complete absence of the enzyme muscle glycogen phosphorylase. Affected people experience symptoms of fatigue and cramping within minutes of exercise and are at risk for acute muscle injury (rhabdomyolysis) and acute renal failure. If the fi...

  4. 75 FR 50878 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-08-18

    ... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 90-30 Airplanes AGENCY: Federal Aviation... McDonnell Douglas Corporation: Amendment 39-16388. Docket No. FAA-2010-0433; Directorate Identifier 2009-NM..., 2010. Affected ADs (b) None. Applicability (c) This AD applies to McDonnell Douglas Corporation Model...

  5. 75 FR 68245 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-11-05

    ...-1043; Directorate Identifier 2010-NM-200-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... McDonnell Douglas Model MD-90-30 airplanes. This proposed AD would require installing new fire handle... airworthiness directive (AD): McDonnell Douglas Corporation: Docket No. FAA-2010-1043; Directorate Identifier...

  6. OpenMC: A state-of-the-art Monte Carlo code for research and development

    International Nuclear Information System (INIS)

    Romano, Paul K.; Horelik, Nicholas E.; Herman, Bryan R.; Nelson, Adam G.; Forget, Benoit; Smith, Kord

    2015-01-01

    Highlights: • OpenMC is an open source Monte Carlo particle transport code. • Solid geometry and continuous-energy physics allow high-fidelity simulations. • Development has focused on high performance and modern I/O techniques. • OpenMC is capable of scaling up to hundreds of thousands of processors. • Other features include plotting, CMFD acceleration, and variance reduction. - Abstract: This paper gives an overview of OpenMC, an open source Monte Carlo particle transport code recently developed at the Massachusetts Institute of Technology. OpenMC uses continuous-energy cross sections and a constructive solid geometry representation, enabling high-fidelity modeling of nuclear reactors and other systems. Modern, portable input/output file formats are used in OpenMC: XML for input, and HDF5 for output. High performance parallel algorithms in OpenMC have demonstrated near-linear scaling to over 100,000 processors on modern supercomputers. Other topics discussed in this paper include plotting, CMFD acceleration, variance reduction, eigenvalue calculations, and software development processes

  7. What would McLuhan say about the smartphone? : applying McLuhan’s tetrad to the smartphone

    NARCIS (Netherlands)

    Isabelle Adam

    2016-01-01

    In this essay, the smartphone as a new technology and medium is analysed with regards to its effects on individuals and society. McLuhan’s tetrad serves as a framework for analysis, consisting of a set of four effects to examine media in their historical context and present environment as well as

  8. Differential glucose metabolism in mice and humans affected by McArdle disease

    DEFF Research Database (Denmark)

    Krag, Thomas O; Pinós, Tomàs; Nielsen, Tue L

    2016-01-01

    McArdle disease (muscle glycogenosis type V) is a disease caused by myophosphorylase deficiency leading to "blocked" glycogen breakdown. A significant but varying glycogen accumulation in especially distal hind limb muscles of mice affected by McArdle disease has recently been demonstrated......, which could lead to lower glycogen accumulation. In comparison, tibialis anterior, extensor digitorum longus, and soleus had massive glycogen accumulation, but few, if any, changes or adaptations in glucose metabolism compared with wild-type mice. The findings suggest plasticity in glycogen metabolism....... In this study, we investigated how myophosphorylase deficiency affects glucose metabolism in hind limb muscle of 20-wk-old McArdle mice and vastus lateralis muscles from patients with McArdle disease. Western blot analysis and activity assay demonstrated that glycogen synthase was inhibited in glycolytic muscle...

  9. MC EMiNEM maps the interaction landscape of the Mediator.

    Directory of Open Access Journals (Sweden)

    Theresa Niederberger

    Full Text Available The Mediator is a highly conserved, large multiprotein complex that is involved essentially in the regulation of eukaryotic mRNA transcription. It acts as a general transcription factor by integrating regulatory signals from gene-specific activators or repressors to the RNA Polymerase II. The internal network of interactions between Mediator subunits that conveys these signals is largely unknown. Here, we introduce MC EMiNEM, a novel method for the retrieval of functional dependencies between proteins that have pleiotropic effects on mRNA transcription. MC EMiNEM is based on Nested Effects Models (NEMs, a class of probabilistic graphical models that extends the idea of hierarchical clustering. It combines mode-hopping Monte Carlo (MC sampling with an Expectation-Maximization (EM algorithm for NEMs to increase sensitivity compared to existing methods. A meta-analysis of four Mediator perturbation studies in Saccharomyces cerevisiae, three of which are unpublished, provides new insight into the Mediator signaling network. In addition to the known modular organization of the Mediator subunits, MC EMiNEM reveals a hierarchical ordering of its internal information flow, which is putatively transmitted through structural changes within the complex. We identify the N-terminus of Med7 as a peripheral entity, entailing only local structural changes upon perturbation, while the C-terminus of Med7 and Med19 appear to play a central role. MC EMiNEM associates Mediator subunits to most directly affected genes, which, in conjunction with gene set enrichment analysis, allows us to construct an interaction map of Mediator subunits and transcription factors.

  10. MC EMiNEM maps the interaction landscape of the Mediator.

    Science.gov (United States)

    Niederberger, Theresa; Etzold, Stefanie; Lidschreiber, Michael; Maier, Kerstin C; Martin, Dietmar E; Fröhlich, Holger; Cramer, Patrick; Tresch, Achim

    2012-01-01

    The Mediator is a highly conserved, large multiprotein complex that is involved essentially in the regulation of eukaryotic mRNA transcription. It acts as a general transcription factor by integrating regulatory signals from gene-specific activators or repressors to the RNA Polymerase II. The internal network of interactions between Mediator subunits that conveys these signals is largely unknown. Here, we introduce MC EMiNEM, a novel method for the retrieval of functional dependencies between proteins that have pleiotropic effects on mRNA transcription. MC EMiNEM is based on Nested Effects Models (NEMs), a class of probabilistic graphical models that extends the idea of hierarchical clustering. It combines mode-hopping Monte Carlo (MC) sampling with an Expectation-Maximization (EM) algorithm for NEMs to increase sensitivity compared to existing methods. A meta-analysis of four Mediator perturbation studies in Saccharomyces cerevisiae, three of which are unpublished, provides new insight into the Mediator signaling network. In addition to the known modular organization of the Mediator subunits, MC EMiNEM reveals a hierarchical ordering of its internal information flow, which is putatively transmitted through structural changes within the complex. We identify the N-terminus of Med7 as a peripheral entity, entailing only local structural changes upon perturbation, while the C-terminus of Med7 and Med19 appear to play a central role. MC EMiNEM associates Mediator subunits to most directly affected genes, which, in conjunction with gene set enrichment analysis, allows us to construct an interaction map of Mediator subunits and transcription factors.

  11. The SO-20.3 MC and A modernization plan final report

    International Nuclear Information System (INIS)

    Longmire, V.L.; Ensslin, Norbert; Files, C.; Joseph, Joshua A. Jr.; Rudy, C.R.; Smith, M.K.; Russo, P.A.; Stevens, R.S.; Strittmatter, R.B.; Wilkey, D.D.; Pickett, C.; Brosey, W.; Swanson, J.

    2004-01-01

    Materials Control and Accountability (MC and A) provides assurance to the nation that nuclear materials are controlled in accordance with their strategic and economic importance and that the misuse, theft or diversion of these materials will be detected. MC and A plays an important part in security at nuclear facilities, especially in addressing threats such as theft of materials, environmental contamination, and nuclear safety incidents associated with nuclear materials. For this reason, it is important that MC and A takes advantage of new technologies and methods in order to provide information on a site's nuclear materials in the most timely and useful manner possible. Within the U.S. Department of Energy (DOE), the Office of Security Policy, Policy Integration and Technical Support Program (SO-20.3) is responsible for the development of safeguards and security technology that enables DOE and NNSA facilities to safeguard their Special Nuclear Materials. The SO-20.3 Program tasked safeguards personnel at Los Alamos National Laboratory to lead a project with representatives from the Y-12 Plant, Lawrence Livermore National Laboratory, and the Savannah River Site to prepare an MC and A Modernization Plan that provides recommendations for development new technologies and methodologies for MC and A in both new and existing DOE facilities. The team was tasked with taking into account new concerns about the protection of nuclear material following the attacks of September 11, 2001. Opportunities for applying new MC and A approaches and technologies that provide increased freedom of operation, increased security and provide a potential for cost savings in existing and new DOE facilities are discussed in this report.

  12. Association between MC4R rs17782313 Polymorphism and Overeating Behaviours

    Science.gov (United States)

    Yilmaz, Zeynep; Davis, Caroline; Loxton, Natalie J.; Kaplan, Allan S.; Levitan, Robert D.; Carter, Jacqueline C.; Kennedy, James L.

    2014-01-01

    Background/Objectives Melanocortins play a crucial role in appetite and weight regulation. Although the melanocortin 4 receptor (MC4R) gene has been repeatedly linked to obesity and antipsychotic-induced weight gain, the mechanism behind how it leads to this effect in still undetermined. The goal of this study was to conduct an in-depth and sophisticated analysis of MC4R polymorphisms, body mass index (BMI), eating behaviour, and depressed mood. Subjects/Methods We genotyped 328 individuals of European ancestry on the following MC4R markers based on the relevant literature on obesity and antipsychotic-induced weight gain: rs571312, rs17782313, rs489693, rs11872992, and rs8087522. Height and weight were measured, and information on depressed mood and overeating behaviours was obtained during the in-person assessment. Results BMI was associated with rs17782313 C allele; however this finding did not survive correction for multiple testing (p=0.018). Although rs17782313 was significantly associated with depressed mood and overeating behaviours, tests of indirect effects indicated that emotional eating and food cravings, rather than depressed mood, uniquely accounted for the effect of this marker and BMI (n=152). Conclusions To our knowledge, this is the first study to investigate the link between MC4R rs17782313, mood and overeating behaviour, as well as to demonstrate possible mechanisms behind MC4R’s influence on body weight. If replicated in a larger sample, these results may have important clinical implications, including potential for the use of MC4R agonists in the treatment of obesity and disordered eating. PMID:24827639

  13. MC2: A Power Conditionning and Distribution Unit for Stratospherics Balloons

    Directory of Open Access Journals (Sweden)

    François Bonnet

    2017-01-01

    Full Text Available For long duration scientific missions with stratospheric balloons (objective of 3 month duration, renewable energy is used. Solar panels with mono crystalline silicon solar cells are mounted on both scientific and avionic gondola. A power conditioning board with Maximum Power Point Tracking (MPPT is designed and currently tested. This board is called MC2: Communicant Conditioning Module. It allows controlling a Li Ion battery charge through PWM regulators. Moreover, outlets ON/OFF commutations associated to overcurrent’s protections are implemented in this board. The battery active thermal control is made by MC2 autonomously. The main design drivers are mass, costs and efficiency. A CAN Bus between MC2 and On Board Computer allows to have a commandability and observability of MC2 through OBC. The overall avionic gondola is designed to be Single Points Failure free by using two segregated chains in order to be compatible with safety rules. The nominal chain is the main chain and use MC2 with renewable energy. The secondary chain uses a primary electrochemical cell which feeds loads in case of undervoltage of the main chain. This overall architecture allows both chains to be designed without SPF free constrains. This paper describes the overall requirements and the design of MC2. The main innovation described in this paper is the way to implement MPPT: the MPPT algorithm is performed at the output of the power converter. This MPPT extracts maximum power of both solar panel characteristics and power converter. The main advantage is that this MPPT uses only one existing sensor (output current of boost converter instead of using current and voltage sensor of each solar panel.

  14. McDonaldization, Islamic teachings, and funerary practices in Kuwait.

    Science.gov (United States)

    Iqbal, Zafar

    2011-01-01

    Drawing on George Ritzer's sociological concept of McDonaldization, this article explores the transformation of burial practices in Kuwait. It is argued that traditional, religious, and private ways of dealing with death have been modernized using the fast-food model of McDonald's. This article examines Islamic teachings on burial and how that model has been applied to the traditional Muslim funerary services, including cemetery management, grave excavation, funeral prayers, burial, and condolences, to make them more efficient vis-a-vis more profitable. Based on personal observations and random interviews, the study finds that the state bureaucracy in Kuwait has made burial rituals more efficient, standardized, calculable, and controlled. Furthermore, several associated irrationalities are also considered. Findings suggest that some individuals may not be happy with these changes but there is no popular resistance to McDonaldization of the burial practices, probably due to the authoritarian and welfare nature of the State of Kuwait.

  15. The Exploration of Political Conflicts and Personal Relationships in Ian McEwan’s The Innocent

    Directory of Open Access Journals (Sweden)

    Mina Abbasiyannejad

    2014-03-01

    Full Text Available Political conflicts have historically affected the relationships of nations. Ian McEwan’s The Innocent is an excellent example of a story set within the web of such a conflict—the Cold War—that was brought about by U.S. and Soviet confrontation over spheres of influence after the Second World War. This article aims to show how Ian McEwan pictures Americanization as a form of cultural politics aimed at spreading American influence throughout the occupied countries such as Germany for political domination. Max Weber’s theory of political power along with semiotics as a tool is the framework of the article. Signs that refer to the Americanization process, including inferences in the dialogues, gestures, choice of food, and even clothing, are scrutinized and interpreted within the socio-political context the of Cold War. The analysis of The Innocent provides an example of the ways in which fiction represents political conflicts permeating personal and intimate relationships, and how such conflicts may result in a sense of mistrust and intrigue among both people and nations.

  16. McKenzie River Focus Watershed Coordination: Year-End Report 2000.

    Energy Technology Data Exchange (ETDEWEB)

    Thrailkil, Jim

    2000-01-01

    This report summarizes accomplishments of the McKenzie River Focus Watershed Council (MWC) in the areas of coordination and administration during Fiscal Year 2000. Coordination and administration consist of prioritization and planning for projects; project management and implementation; procurement of funding for long-term support of the Council; and watershed education/outreach program for residents and local schools. Key accomplishments in the area of project planning include coordinating: monthly Council and executive committee meetings; staffing the Upper Willamette Spring Chinook Working Group; staffing the water quality technical committee; and guiding education and stewardship projects. Key accomplishments in the area of project management include the completion of the McKenzie-Willamette Confluence Assessment; securing funds for project planning in the confluence area; near completion of the BPA funded McKenzie sub-basin assessment; development of a framework for a McKenzie Watershed Conservation Strategy; an evaluation of Council's monitoring programs - ambient water quality, storm-event water quality, Tier III water quality, and macroinvertebrate monitoring. The Council, in cooperation with the McKenzie River Cooperative, completed habitat enhancements in the Gate Creek and Deer Creek sub-watersheds. This partnership recently submitted Bring Back the Natives grant for initiation of projects in other McKenzie tributaries. The Council will also be working with a local business to develop a river-side riparian enhancement and native landscaping project on the lodge grounds. This will serve as a demonstration project for blending fish and wildlife habitat concerns with maintaining grounds for business opportunities. Accomplishments in the area of procurement of funding included developing the FY2000 Scope of Work and budget for approval by the Council and BPA; providing quarterly budget and work program progress reports to the Council; and securing

  17. 75 FR 21528 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-04-26

    ...-0433; Directorate Identifier 2009-NM-117-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... main landing gear (MLG) during gear extension, damaging the hydraulic system on McDonnell Douglas.... The retract cylinder support fittings for the MLG on McDonnell Douglas Model MD-80 series airplanes...

  18. Fat metabolism during exercise in patients with McArdle disease

    DEFF Research Database (Denmark)

    Ørngreen, M C; Jeppesen, T D; Andersen, S Tvede

    2009-01-01

    carbohydrate oxidation was lower, during exercise in patients with McArdle disease vs healthy controls. We found augmented fat oxidation with the onset of a second wind, but further increases in FFA availability, as exercise continued, did not result in further increases in FAO. CONCLUSION: These results......OBJECTIVE: It is known that muscle phosphorylase deficiency restricts carbohydrate utilization, but the implications for muscle fat metabolism have not been studied. We questioned whether patients with McArdle disease can compensate for the blocked muscle glycogen breakdown by enhancing fat...... indicate that patients with McArdle disease have exaggerated fat oxidation during prolonged, low-intensity exercise and that increased fat oxidation may be an important mechanism of the spontaneous second wind. The fact that increasing availability of free fatty acids with more prolonged exercise did...

  19. Edwin M. McMillan, A biographical sketch

    International Nuclear Information System (INIS)

    Lofgren, E.J.

    1994-07-01

    Edwin M. McMillan was one of the great scientists of the middle years of this century. He made notable contributions to nuclear, and particle physics, the chemistry of transuranic elements, and accelerator physics

  20. Solar Imagery - Composites - Synoptic Maps - McIntosh

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — In 1964 (solar cycle 20) Patrick McIntosh began creating hand-drawn synoptic maps of solar activity, based on Hydrogen alpha (H?) imaging measurements. These...

  1. uvby photometry in McCormick proper motion fields

    Science.gov (United States)

    Degewij, J.

    1982-01-01

    The Danish 50 cm telescope at the European Southern Observatory was used to obtain high-precision uvby photometry for 50 F2 to G2 stars, with V values in the 9.4-12.3 mag range, which were selected in the southern galactic polar regions of the McCormick proper motion fields and measured on six different nights. The brighter stars are found to systematically exhibit smaller m(1) indices, of about 0.02 mag, upon comparison with the earlier data of Blaauw et al (1976). Single measurements are given for 98 stars in eight McCormick fields at intermediate southern galactic latitudes.

  2. Robotic filter handling at McGuire nuclear station

    International Nuclear Information System (INIS)

    Hilley, J.R. Jr.; Twiggs, J.G.

    1988-01-01

    The application of a robotics system for the packaging of radioactive spent filters was justified on the basis of radiation dose savings, i.e., ALARA considerations, and the benefits associated with defining additional applications of this technology once experienced is gained. This particular gantry-mounted manipulator system was chosen for its ease of relocation and potential use in other hazardous areas at the McGuire nuclear station. The initial investment is estimated to be recovered in 6 to 7 yr. The robotic system is on site at McGuire, with installation and bunker modifications currently scheduled for completion in 1988. Personnel training on the system will start shortly thereafter

  3. The MC21 Monte Carlo Transport Code

    International Nuclear Information System (INIS)

    Sutton TM; Donovan TJ; Trumbull TH; Dobreff PS; Caro E; Griesheimer DP; Tyburski LJ; Carpenter DC; Joo H

    2007-01-01

    MC21 is a new Monte Carlo neutron and photon transport code currently under joint development at the Knolls Atomic Power Laboratory and the Bettis Atomic Power Laboratory. MC21 is the Monte Carlo transport kernel of the broader Common Monte Carlo Design Tool (CMCDT), which is also currently under development. The vision for CMCDT is to provide an automated, computer-aided modeling and post-processing environment integrated with a Monte Carlo solver that is optimized for reactor analysis. CMCDT represents a strategy to push the Monte Carlo method beyond its traditional role as a benchmarking tool or ''tool of last resort'' and into a dominant design role. This paper describes various aspects of the code, including the neutron physics and nuclear data treatments, the geometry representation, and the tally and depletion capabilities

  4. 75 FR 66653 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-10-29

    ... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 90-30 Airplanes AGENCY: Federal Aviation...-15667 (73 FR 52203, September 9, 2008), and adding the following new AD: 2010-22-04 McDonnell Douglas... supersedes AD 2008-18-10, Amendment 39-15667. Applicability (c) This AD applies to McDonnell Douglas...

  5. Audiovisual sentence recognition not predicted by susceptibility to the McGurk effect.

    Science.gov (United States)

    Van Engen, Kristin J; Xie, Zilong; Chandrasekaran, Bharath

    2017-02-01

    In noisy situations, visual information plays a critical role in the success of speech communication: listeners are better able to understand speech when they can see the speaker. Visual influence on auditory speech perception is also observed in the McGurk effect, in which discrepant visual information alters listeners' auditory perception of a spoken syllable. When hearing /ba/ while seeing a person saying /ga/, for example, listeners may report hearing /da/. Because these two phenomena have been assumed to arise from a common integration mechanism, the McGurk effect has often been used as a measure of audiovisual integration in speech perception. In this study, we test whether this assumed relationship exists within individual listeners. We measured participants' susceptibility to the McGurk illusion as well as their ability to identify sentences in noise across a range of signal-to-noise ratios in audio-only and audiovisual modalities. Our results do not show a relationship between listeners' McGurk susceptibility and their ability to use visual cues to understand spoken sentences in noise, suggesting that McGurk susceptibility may not be a valid measure of audiovisual integration in everyday speech processing.

  6. Isolation of chlamydia in irradiated and non-irradiated McCoy cells

    International Nuclear Information System (INIS)

    Johnson, L.; Harper, I.A.

    1975-01-01

    Specimens from eye and genital tract were cultured in parallel in irradiated and non-irradiated McCoy cells and the frequency of isolation of chlamydia using these culture methods was compared. There was a significant difference between the frequencies of isolation; irradiated McCoy cells produced a greater number of positive results. (author)

  7. 75 FR 38056 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-07-01

    ...-0645; Directorate Identifier 2009-NM-200-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas..., September 9, 2008), for certain McDonnell Douglas Corporation Model MD-90-30 airplanes. That AD requires a... fasteners in the aft mount support fitting of the left and right engines on 29 McDonnell Douglas Corporation...

  8. Sim1 Neurons Are Sufficient for MC4R-Mediated Sexual Function in Male Mice.

    Science.gov (United States)

    Semple, Erin; Hill, Jennifer W

    2018-01-01

    Sexual dysfunction is a poorly understood condition that affects up to one-third of men around the world. Existing treatments that target the periphery do not work for all men. Previous studies have shown that central melanocortins, which are released by pro-opiomelanocortin neurons in the arcuate nucleus of the hypothalamus, can lead to male erection and increased libido. Several studies specifically implicate the melanocortin 4 receptor (MC4R) in the central control of sexual function, but the specific neural circuitry involved is unknown. We hypothesized that single-minded homolog 1 (Sim1) neurons play an important role in the melanocortin-mediated regulation of male sexual behavior. To test this hypothesis, we examined the sexual behavior of mice expressing MC4R only on Sim1-positive neurons (tbMC4Rsim1 mice) in comparison with tbMC4R null mice and wild-type controls. In tbMC4Rsim1 mice, MC4R reexpression was found in the medial amygdala and paraventricular nucleus of the hypothalamus. These mice were paired with sexually experienced females, and their sexual function and behavior was scored based on mounting, intromission, and ejaculation. tbMC4R null mice showed a longer latency to mount, a reduced intromission efficiency, and an inability to reach ejaculation. Expression of MC4R only on Sim1 neurons reversed the sexual deficits seen in tbMC4R null mice. This study implicates melanocortin signaling via the MC4R on Sim1 neurons in the central control of male sexual behavior. Copyright © 2018 Endocrine Society.

  9. The McDonaldization of Academic Libraries?

    Science.gov (United States)

    Quinn, Brian

    2000-01-01

    Discusses the McDonaldization thesis that suggests that many aspects of the fast food industry are making their way into other areas of society. Explores whether this thesis is applicable to academic libraries, focusing on efficiency, calculability, predictability, control, user expectations, pros and cons of teams, and creativity and information…

  10. SNPs of melanocortin 4 receptor (MC4R) associated with body weight in Beagle dogs.

    Science.gov (United States)

    Zeng, Ruixia; Zhang, Yibo; Du, Peng

    2014-01-01

    Melanocortin 4 receptor (MC4R), which is associated with inherited human obesity, is involoved in food intake and body weight of mammals. To study the relationships between MC4R gene polymorphism and body weight in Beagle dogs, we detected and compared the nucleotide sequence of the whole coding region and 3'- and 5'- flanking regions of the dog MC4R gene (1214 bp). In 120 Beagle dogs, two SNPs (A420C, C895T) were identified and their relation with body weight was analyzed with RFLP-PCR method. The results showed that the SNP at A420C was significantly associated with canine body weight trait when it changed amino acid 101 of the MC4R protein from asparagine to threonine, while canine body weight variations were significant in female dogs when MC4R nonsense mutation at C895T. It suggested that the two SNPs might affect the MC4R gene's function which was relative to body weight in Beagle dogs. Therefore, MC4R was a candidate gene for selecting different size dogs with the MC4R SNPs (A420C, C895T) being potentially valuable as a genetic marker.

  11. Assessing the health impact of transnational corporations: a case study on McDonald's Australia.

    Science.gov (United States)

    Anaf, Julia; Baum, Frances E; Fisher, Matt; Harris, Elizabeth; Friel, Sharon

    2017-02-06

    The practices of transnational corporations affect population health through production methods, shaping social determinants of health, or influencing the regulatory structures governing their activities. There has been limited research on community exposures to TNC policies and practices. Our pilot research used McDonald's Australia to test methods for assessing the health impacts of one TNC within Australia. We adapted existing Health Impact Assessment methods to assess McDonald's activities. Data identifying potential impacts were sourced through document analysis, including McDonald's corporate literature; media analysis and semi-structured interviews. We commissioned a spatial and socioeconomic analysis of McDonald's restaurants in Australia through Geographic Information System technology. The data was mapped against a corporate health impact assessment framework which included McDonald's Australia's political and business practices; products and marketing; workforce, social, environmental and economic conditions; and consumers' health related behaviours. We identified both positive and detrimental aspects of McDonald's Australian operations across the scope of the CHIA framework. We found that McDonald's outlets were slightly more likely to be located in areas of lower socioeconomic status. McDonald's workplace conditions were found to be more favourable than those in many other countries which reflects compliance with Australian employment regulations. The breadth of findings revealed the need for governments to strengthen regulatory mechanisms that are conducive to health; the opportunity for McDonald's to augment their corporate social responsibility initiatives and bolster reputational endorsement; and civil society actors to inform their advocacy towards health and equity outcomes from TNC operations. Our study indicates that undertaking a corporate health impact assessment is possible, with the different methods revealing sufficient information to

  12. Association of MC4R gene variants with carcass and meat quality ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-08-04

    Aug 4, 2009 ... 1College of Animal Science and Technology, Northwest A and F ... MC4R belongs to a seven-transmembrane G-protein-coupled receptor which may regulate body ... targeted disruption of the MC4R gene in mice causes.

  13. Influence of silencing the MC4R gene by lentivirusmediated RNA ...

    African Journals Online (AJOL)

    Melanocortin receptor 4 (MC4R) is a key element in the mechanisms used to regulate both aspects of keeping the balance between energy uptake and energy expenditure. MC4R was knocked down by lentivirus-mediated shRNA expressing plasmids, which were controlled by the U6 promoter in bovine fibroblast cells, and ...

  14. Verification of SuperMC with ITER C-Lite neutronic model

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Shu [School of Nuclear Science and Technology, University of Science and Technology of China, Hefei, Anhui, 230027 (China); Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui, 230031 (China); Yu, Shengpeng [Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui, 230031 (China); He, Peng, E-mail: peng.he@fds.org.cn [Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui, 230031 (China)

    2016-12-15

    Highlights: • Verification of the SuperMC Monte Carlo transport code with ITER C-Lite model. • The modeling of the ITER C-Lite model using the latest SuperMC/MCAM. • All the calculated quantities are consistent with MCNP well. • Efficient variance reduction methods are adopted to accelerate the calculation. - Abstract: In pursit of accurate and high fidelity simulation, the reference model of ITER is becoming more and more detailed and complicated. Due to the complexity in geometry and the thick shielding of the reference model, the accurate modeling and precise simulaion of fusion neutronics are very challenging. Facing these difficulties, SuperMC, the Monte Carlo simulation software system developed by the FDS Team, has optimized its CAD interface for the automatic converting of more complicated models and increased its calculation efficiency with advanced variance reduction methods To demonstrate its capabilites of automatic modeling, neutron/photon coupled simulation and visual analysis for the ITER facility, numerical benchmarks using the ITER C-Lite neutronic model were performed. The nuclear heating in divertor and inboard toroidal field (TF) coils and a global neutron flux map were evaluated. All the calculated nuclear heating is compared with the results of the MCNP code and good consistencies between the two codes is shown. Using the global variance reduction methods in SuperMC, the average speed-up is 292 times for the calculation of inboard TF coils nuclear heating, and 91 times for the calculation of global flux map, compared with the analog run. These tests have shown that SuperMC is suitable for the design and analysis of ITER facility.

  15. Human reliability-based MC and A models for detecting insider theft

    International Nuclear Information System (INIS)

    Duran, Felicia Angelica; Wyss, Gregory Dane

    2010-01-01

    Material control and accounting (MC and A) safeguards operations that track and account for critical assets at nuclear facilities provide a key protection approach for defeating insider adversaries. These activities, however, have been difficult to characterize in ways that are compatible with the probabilistic path analysis methods that are used to systematically evaluate the effectiveness of a site's physical protection (security) system (PPS). MC and A activities have many similar characteristics to operator procedures performed in a nuclear power plant (NPP) to check for anomalous conditions. This work applies human reliability analysis (HRA) methods and models for human performance of NPP operations to develop detection probabilities for MC and A activities. This has enabled the development of an extended probabilistic path analysis methodology in which MC and A protections can be combined with traditional sensor data in the calculation of PPS effectiveness. The extended path analysis methodology provides an integrated evaluation of a safeguards and security system that addresses its effectiveness for attacks by both outside and inside adversaries.

  16. Integrating bar-code devices with computerized MC and A systems

    International Nuclear Information System (INIS)

    Anderson, L.K.; Boor, M.G.; Hurford, J.M.

    1998-01-01

    Over the past seven years, Los Alamos National Laboratory developed several generations of computerized nuclear materials control and accountability (MC and A) systems for tracking and reporting the storage, movement, and management of nuclear materials at domestic and international facilities. During the same period, Oak Ridge National Laboratory was involved with automated data acquisition (ADA) equipment, including installation of numerous bar-code scanning stations at various facilities to serve as input devices to computerized systems. Bar-code readers, as well as other ADA devices, reduce input errors, provide faster input, and allow the capture of data in remote areas where workstations do not exist. Los Alamos National Laboratory and Oak Ridge National Laboratory teamed together to implement the integration of bar-code hardware technology with computerized MC and A systems. With the expertise of both sites, the two technologies were successfully merged with little difficulty. Bar-code input is now available with several functions of the MC and A systems: material movements within material balance areas (MBAs), material movements between MBAs, and physical inventory verification. This paper describes the various components required for the integration of these MC and A systems with the installed bar-code reader devices and the future directions for these technologies

  17. McDonaldization and Job Insecurity

    OpenAIRE

    Emeka W. Dumbili

    2013-01-01

    The article examines how and why the McDonaldization of banking system in Nigeria engenders job insecurity. This is imperative because it provides an explicit revelation of the root causes of job insecurity in the sector that other scholars have totally omitted. No Nigerian scholar has applied the thesis in relation to job insecurity, which is the major problem in Nigeria’s banking industry. The article based on the an...

  18. Crest Factor Reduction in MC-CDMA Employing Carrier Interferometry Codes

    Directory of Open Access Journals (Sweden)

    Natarajan Balasubramaniam

    2004-01-01

    Full Text Available This paper addresses signal compactness issues in MC-CDMA employing carrier interferometry codes using the measure of crest factor (CF. Carrier interferometry codes, applied to N -carrier MC-CDMA systems, enable 2N users to simultaneously share the system bandwidth with minimal degradation in performance (relative to the N -orthogonal-user case. First, for a fully loaded ( K=N and K=2N users MC-CDMA system with practical values of N , it is shown that the CF in downlink transmission demonstrates desirable properties of low mean and low variance. The downlink CF degrades when the number of users in the system decreases. Next, the high CF observed in the uplink is characterized and the poor CF in a partially loaded downlink as well as uplink is effectively combated using Schroeder's analytical CF reduction techniques.

  19. Density functional calculations on the geometric structure and properties of the 3d transition metal atom doped endohedral fullerene M@C20F20 (M = Sc–Ni)

    International Nuclear Information System (INIS)

    Chun-Mei, Tang; Wei-Hua, Zhu; Kai-Ming, Deng

    2010-01-01

    This paper uses the generalised gradient approximation based on density functional theory to analyse the geometric structure and properties of the 3d transition metal atom doped endohedral fullerene M@C 20 F 20 (M = Sc–Ni). The geometric optimization shows that the cage centre is the most stable position for M, forming the structure named as M@C 20 F 20 -4. The inclusion energy, zero-point energy, and energy gap calculations tell us that N@C 20 F 20 -4 should be thermodynamically and kinetically stablest. M@C 20 F 20 -4 (M = Sc–Co) possesses high magnetic moments varied from 1 to 6 μ B , while Ni@C 20 F 20 -4 is nonmagnetic. The Ni–C bond in Ni@C 20 F 20 -4 contains both the covalent and ionic characters

  20. Tribute to Professor Anthony J. McMichael

    Directory of Open Access Journals (Sweden)

    Ashwin Swaminathan

    2014-11-01

    Full Text Available Emeritus Professor A. J. “Tony” McMichael (1942–2014 was an internationally renowned and pioneering Australian academic and advocate in epidemiology, who was passionate about understanding the influences of the environment on human health. In an illustrious career spanning more than four decades, he made significant contributions to the scientific community and policy discourse—including ground-breaking research related to the health of children. McMichael was a prolific academic writer with over 300 peer-reviewed papers; 160 book chapters and two sole-authored books. However, his outstanding talent was for integrating complex and seemingly unrelated strands from the environmental and health sciences into a cohesive narrative—and highlighting its relevance to lay persons, scientists and governments alike. He was instrumental in validating this nascent field of research and inspiring many others to follow his lead.

  1. O mundo de Ronald McDonald: sobre a marca publicitária e a socialidade midiática The world of Ronald McDonald: on the trademark and the mediatic sociality

    Directory of Open Access Journals (Sweden)

    Isleide Arruda Fontenelle

    2002-06-01

    Full Text Available O palhaço Ronald McDonald -- uma das imagens de marca da Corporação McDonald's -- é tomado como paradigma para pensarmos as relações entre mercado, mídia e entretenimento, as quais tem uma ligação direta com o que estamos conceituando como "socialidade midiática". Enquanto uma metáfora ideal de uma propaganda que parece não querer mais fazer sentido, a história do palhaço nos permite desvendar os sentidos contidos em duas das principais práticas do marketing moderno, a propaganda e a publicidade, revelando-nos como, entre o nonsense da propaganda contemporânea e uma publicidade que fundiu realidade e ilusão, há uma relação visceral entre mídia e publicidade, que estabelece uma nova forma de comunicação, na qual o sujeito torna-se apenas um meio para fins que ele sabe quais são, mas, paradoxalmente, age como se não soubesse. Tal paradoxo é revelador de uma forma de subjetividade profundamente marcada pela mídia enquanto agente socializador, na medida em que a atuação da mídia como mediador da socialidade contemporânea acabou por alterar o nosso universo perceptivo, saturando o nosso imaginário de uma forma radicalmente nova. Some-se a isso o fato de que a "socialidade midiática" implica uma nova forma de representação do sujeito no registro do "espetáculo", no sentido de que "estar na imagem é existir". Desnecessário dizer o quanto essas questões precisam ser contempladas pelos estudos contemporâneos sobre os processos de socialização e o quanto são desafiadoras para aqueles que atuam no universo da educação.The clown Ronald McDonald -- one of the trademarks of the McDonald's Corporation -- is taken as a paradigm to reflect upon the relations between market, media, and entertainment, which have a direct link with what we define as "mediatic sociality". As an ideal metaphor of an advertising that no longer seems to attempt to make sense, the story of the clown allows us to unveil the meanings contained

  2. Ronald McDonald pregunta: "Puedes decir: 'dostortosdepurocarnederessalsaespeciallechugagueso- pepinillosycebollasenunpanconsemillasdeajonjoli'?" (Ronald McDonald Asks: "Can You Say: 'Two-All-Beef-Patties-Special-Sauce-Lettuce-Cheese-Pickles-Onions-On- A-Sesame-Seed-Bun'?" Activities in Spanish).

    Science.gov (United States)

    Headrick, Robert J., Jr.

    This booklet is intended for classroom use in first-year high school Spanish to acquaint students with the McDonald's fast food restaurants in Costa Rica. The specific objectives are for the student to: (1) discuss the similarities and differences between the American and Costa Rican McDonald's, (2) set up a miniature McDonald's in the classroom,…

  3. Biasing transition rate method based on direct MC simulation for probabilistic safety assessment

    Institute of Scientific and Technical Information of China (English)

    Xiao-Lei Pan; Jia-Qun Wang; Run Yuan; Fang Wang; Han-Qing Lin; Li-Qin Hu; Jin Wang

    2017-01-01

    Direct Monte Carlo (MC) simulation is a powerful probabilistic safety assessment method for accounting dynamics of the system.But it is not efficient at simulating rare events.A biasing transition rate method based on direct MC simulation is proposed to solve the problem in this paper.This method biases transition rates of the components by adding virtual components to them in series to increase the occurrence probability of the rare event,hence the decrease in the variance of MC estimator.Several cases are used to benchmark this method.The results show that the method is effective at modeling system failure and is more efficient at collecting evidence of rare events than the direct MC simulation.The performance is greatly improved by the biasing transition rate method.

  4. A Malus crabapple chalcone synthase gene, McCHS, regulates red petal color and flavonoid biosynthesis.

    Directory of Open Access Journals (Sweden)

    Deqiang Tai

    Full Text Available Chalcone synthase is a key and often rate-limiting enzyme in the biosynthesis of anthocyanin pigments that accumulate in plant organs such as flowers and fruits, but the relationship between CHS expression and the petal coloration level in different cultivars is still unclear. In this study, three typical crabapple cultivars were chosen based on different petal colors and coloration patterns. The two extreme color cultivars, 'Royalty' and 'Flame', have dark red and white petals respectively, while the intermediate cultivar 'Radiant' has pink petals. We detected the flavoniods accumulation and the expression levels of McCHS during petals expansion process in different cultivars. The results showed McCHS have their special expression patterns in each tested cultivars, and is responsible for the red coloration and color variation in crabapple petals, especially for color fade process in 'Radiant'. Furthermore, tobacco plants constitutively expressing McCHS displayed a higher anthocyanins accumulation and a deeper red petal color compared with control untransformed lines. Moreover, the expression levels of several anthocyanin biosynthetic genes were higher in the transgenic McCHS overexpressing tobacco lines than in the control plants. A close relationship was observed between the expression of McCHS and the transcription factors McMYB4 and McMYB5 during petals development in different crabapple cultivars, suggesting that the expression of McCHS was regulated by these transcription factors. We conclude that the endogenous McCHS gene is a critical factor in the regulation of anthocyanin biosynthesis during petal coloration in Malus crabapple.

  5. The McDonald’s Inverse Weibull Distribution

    Directory of Open Access Journals (Sweden)

    Saman Hanif Shahbaz

    2016-12-01

    Full Text Available We have proposed a new Inverse Weibull distribution by using the generalized Beta distribution of McDonald (1984. Basic properties of the proposed distribution has been studied. Parameter estimation has been discussed alongside an illustrative example.

  6. Flow Control and Design Assessment for Drainage System at McMurdo Station, Antarctica

    Science.gov (United States)

    2014-11-24

    Drainage System at McMurdo Station, Antarctica Co ld R eg io ns R es ea rc h an d En gi ne er in g La bo ra to ry Rosa Affleck, Meredith...Flow Control and Design Assessment for Drainage System at McMurdo Station, Antarctica Rosa Affleck, Meredith Carr, and Brendan West Cold Regions...Characterization and Variations at McMurdo Station, Antarctica . ERDC/CRREL TR-14-6. Hanover, NH: U.S. Army Engineer Research and Development Center

  7. GPM GROUND VALIDATION NCAR CLOUD MICROPHYSICS PARTICLE PROBES MC3E V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The GPM Ground Validation NCAR Cloud Microphysics Particle Probes MC3E dataset was collected during the Midlatitude Continental Convective Clouds Experiment (MC3E),...

  8. Johnson-McMillin microtia syndrome: New additional family

    Directory of Open Access Journals (Sweden)

    Nagwa Abdel-Meguid

    2014-01-01

    Full Text Available Microtia is a congenital anomaly that is found with different prevalence among various populations. The exact etiology of ear anomalies is still unknown. We describe a new additional family with this rare disorder; Johnson-McMillin syndrome (JMS where mother, son, and distant grandmother have multiple features of JMS in the form of microtia, facial asymmetry, ear malformation, hearing defect, and hypotrichosis. Variable presentations in this family could be referred to phenotype variation supporting an autosomal dominant pattern of inheritance. We observed that the mother was very sad and suffered from feelings of guilt. We found that she had isolated herself from family and community out of fear of being stigmatized and hurt. We concluded that the occurrence of microtia is of public health importance, adhering to traditional marriage customs in Egypt increases women′s risk of giving birth to a disabled child, yet the mothers are blamed and shamed for their children′s birth defects by their husbands, families, and communities, while the fathers are not stigmatized.

  9. McArthur River project - the future of Key Lake

    International Nuclear Information System (INIS)

    Spross, J.

    1994-01-01

    The Key Lake mill has operated since the fall of 1983. The ore from both Key Lake open pits will be depleted by 1997. It is planned to use this mill, located about 60 km southwest of McArthur, to process the McArthur River ore. While the geological data collected so far on the McArthur deposit are encouraging, more information of the deposit is needed before any detailed mine planning can begin. The surface drilling program identified the orebody and provided information on the geomechanical and hydrological properties of the overlying sandstone. It was proposed to conduct an underground exploration program to further delineate the orebody. This was approved following a public hearing and review process. This program involves the sinking of a 630 metre deep shaft and the driving of one or two drifts along a portion of the orebody. From these drifts, exploration drilling every 10 m to 15 m through the orebody will provide the information required for the preparation of a feasibility study and an Environmental Impact Statement (EIS). (author). 4 refs., 8 figs

  10. The Midlatitude Continental Convective Clouds Experiment (MC3E)

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, Mark P.; Petersen, Walt A.; Bansemer, Aaron; Bharadwaj, Nitin; Carey, Larry; Cecil, D. J.; Collis, Scott M.; Del Genio, Anthony D.; Dolan, Brenda A.; Gerlach, J.; Giangrande, Scott; Heymsfield, Andrew J.; Heymsfield, Gerald; Kollias, Pavlos; Lang, T. J.; Nesbitt, Steve W.; Neumann, Andrea; Poellot, M. R.; Rutledge, Steven A.; Schwaller, Mathew R.; Tokay, Ali; Williams, C. R.; Wolff, D. B.; Xie, Shaocheng; Zipser, Edward J.

    2016-10-18

    The Midlatitude Continental Convective Clouds Experiment (MC3E), a field program jointly led by the U.S. Department of Energy’s Atmospheric Radiation Measurement program and the NASA Global Precipitation Measurement (GPM) Mission, was conducted in south-central Oklahoma during April – May 2011. MC3E science objectives were motivated by the need to improve understanding of midlatitude continental convective cloud system lifecycles, microphysics, and GPM precipitation retrieval algorithms. To achieve these objectives a multi-scale surface- and aircraft-based in situ and remote sensing observing strategy was employed. A variety of cloud and precipitation events were sampled during the MC3E, of which results from three deep convective events are highlighted. Vertical structure, air motions, precipitation drop-size distributions and ice properties were retrieved from multi-wavelength radar, profiler, and aircraft observations for an MCS on 11 May. Aircraft observations for another MCS observed on 20 May were used to test agreement between observed radar reflectivities and those calculated with forward-modeled reflectivity and microwave brightness temperatures using in situ particle size distributions and ice water content. Multi-platform observations of a supercell that occurred on 23 May allowed for an integrated analysis of kinematic and microphysical interactions. A core updraft of 25 ms-1 supported growth of hail and large rain drops. Data collected during the MC3E campaign is being used in a number of current and ongoing research projects and is available through the DOE ARM and NASA data archives.

  11. Life science experiments during parabolic flight: The McGill experience

    Science.gov (United States)

    Watt, D. G. D.

    1988-01-01

    Over the past twelve years, members of the Aerospace Medical Research Unit of McGill University have carried out a wide variety of tests and experiments in the weightless condition created by parabolic flight. This paper discusses the pros and cons of that environment for the life scientist, and uses examples from the McGill program of the types of activities which can be carried out in a transport aircraft such as the NASA KC-135.

  12. The heart of McDonaldization: the perspective of the other.

    OpenAIRE

    Brimm, Morissa

    2010-01-01

    This dissertation aims to investigate the effect of organisational culture change on job satisfaction and work motivation from the perspective of the employees. McDonald’s Restaurants have been chosen due to having embraced organisational change in the last five years. One particular branch has been chosen – Castle Marina McDonald’s, Nottingham – for analysis. Triangulation was used to collect the data needed for my research; methods used were both qualitative and quantitative to provide rich...

  13. Understanding McDonald's Among the "World’s Most Ethical Companies"

    OpenAIRE

    De Blasio, Gregory G.

    2008-01-01

    The animal welfare policies and related public communication initiatives of McDonald’s corporation are examined in the context of the organization being named as one of the world’s most ethical organizations. The result is a framework for understanding how McDonald’s and similar organizations could warrant the status of a most ethical company. Specifically, the narrative strength of the company’s articulation of an animal welfare policy and its ongoing promotion as a legitimizing ...

  14. Early and late beta-band power reflect audiovisual perception in the McGurk illusion.

    Science.gov (United States)

    Roa Romero, Yadira; Senkowski, Daniel; Keil, Julian

    2015-04-01

    The McGurk illusion is a prominent example of audiovisual speech perception and the influence that visual stimuli can have on auditory perception. In this illusion, a visual speech stimulus influences the perception of an incongruent auditory stimulus, resulting in a fused novel percept. In this high-density electroencephalography (EEG) study, we were interested in the neural signatures of the subjective percept of the McGurk illusion as a phenomenon of speech-specific multisensory integration. Therefore, we examined the role of cortical oscillations and event-related responses in the perception of congruent and incongruent audiovisual speech. We compared the cortical activity elicited by objectively congruent syllables with incongruent audiovisual stimuli. Importantly, the latter elicited a subjectively congruent percept: the McGurk illusion. We found that early event-related responses (N1) to audiovisual stimuli were reduced during the perception of the McGurk illusion compared with congruent stimuli. Most interestingly, our study showed a stronger poststimulus suppression of beta-band power (13-30 Hz) at short (0-500 ms) and long (500-800 ms) latencies during the perception of the McGurk illusion compared with congruent stimuli. Our study demonstrates that auditory perception is influenced by visual context and that the subsequent formation of a McGurk illusion requires stronger audiovisual integration even at early processing stages. Our results provide evidence that beta-band suppression at early stages reflects stronger stimulus processing in the McGurk illusion. Moreover, stronger late beta-band suppression in McGurk illusion indicates the resolution of incongruent physical audiovisual input and the formation of a coherent, illusory multisensory percept. Copyright © 2015 the American Physiological Society.

  15. Nákup franchisy: založení provozovny McDonald's

    OpenAIRE

    Janová, Lucie

    2015-01-01

    Předmětem této diplomové práce je vytvořit podnikatelský záměr na zřízení pobočky McDonald´s formou franchisy. První část práce je zaměřena na teorii této problematiky. V analytické části za pomoci několika analýz bude zjištěno, jestli založení nové pobočky bude mít smysl. A ve třetí praktické části jsou řešeny podrobnosti vytvoření pobočky McDonald´s. Deal of this master´s thesis is processing of a business plan for a new McDonald’s franchising branch. The first part of the thesis focuses...

  16. La prueba de McTaggart de la irrealidad del tiempo

    Directory of Open Access Journals (Sweden)

    Eduardo Shore

    2010-10-01

    Full Text Available McTaggart se apoya en el hecho de que no percibimos el tiempo en si mismo, un tiempo vacio de sucesos:  lo que en verdad percibimos es el transcurrir de los acontecimientos, tanto de los extemos como los de nuestro propio estado intemo en la conciencia. Todo el desarrollo de McTaggart y tambien su originalidad, consiste en el desentraiiamiento del mecanismo por el cual aprehendemos el caracter temporal del acaecer, a traves del cual tenemos la ilusión de que percibimos el tiempo. De ese analisis se desprende su tesis: La manera de captar lo temporal es contradictoria en si misma, par lo que, si el significante es contradictorio, lo significado, en este caso el tiempo, es nada: el nihil privativum kantiano" Pregunto: no tendra razón McTaggart, en cuyo caso podria decirse que los sucesos "son" el tiempo?

  17. McNutt to Be Nominated to Lead U.S. Geological Survey

    Science.gov (United States)

    Showstack, Randy

    2009-07-01

    U.S. President Barack Obama announced on 9 July his intention to nominate Marcia McNutt as director of the U.S. Geological Survey (USGS) and science advisor to the Secretary of the Interior. McNutt, who served as AGU president from 2000 to 2002, currently is president and chief executive officer of the Monterey Bay Aquarium Research Institute, in Moss Landing, Calif. “Scientific information from the U.S. Geological Survey is crucial to solving the most important problems facing society—finding sufficient supplies of fresh water and clean energy and providing accurate information that allows citizens to prepare intelligently for climate change. I look forward to leading such a respected institution at this critical time,” McNutt said.

  18. MC2-2: a code to calculate fast neutron spectra and multigroup cross sections

    International Nuclear Information System (INIS)

    Henryson, H. II; Toppel, B.J.; Stenberg, C.G.

    1976-06-01

    MC 2 -2 is a program to solve the neutron slowing down problem using basic neutron data derived from the ENDF/B data files. The spectrum calculated by MC 2 -2 is used to collapse the basic data to multigroup cross sections for use in standard reactor neutronics codes. Four different slowing down formulations are used by MC 2 -2: multigroup, continuous slowing down using the Goertzel-Greuling or Improved Goertzel-Greuling moderating parameters, and a hyper-fine-group integral transport calculation. Resolved and unresolved resonance cross sections are calculated accounting for self-shielding, broadening and overlap effects. This document provides a description of the MC 2 -2 program. The physics and mathematics of the neutron slowing down problem are derived and detailed information is provided to aid the MC 2 -2 user in preparing input for the program and implementation of the program on IBM 370 or CDC 7600 computers

  19. Detection of Echinococcus multilocularis by MC-PCR: evaluation of diagnostic sensitivity and specificity without gold standard

    Directory of Open Access Journals (Sweden)

    Helene Wahlström

    2016-03-01

    Full Text Available Introduction: A semi-automated magnetic capture probe-based DNA extraction and real-time PCR method (MC-PCR, allowing for a more efficient large-scale surveillance of Echinococcus multilocularis occurrence, has been developed. The test sensitivity has previously been evaluated using the sedimentation and counting technique (SCT as a gold standard. However, as the sensitivity of the SCT is not 1, test characteristics of the MC-PCR was also evaluated using latent class analysis, a methodology not requiring a gold standard. Materials and methods: Test results, MC-PCR and SCT, from a previous evaluation of the MC-PCR using 177 foxes shot in the spring (n=108 and autumn 2012 (n=69 in high prevalence areas in Switzerland were used. Latent class analysis was used to estimate the test characteristics of the MC-PCR. Although it is not the primary aim of this study, estimates of the test characteristics of the SCT were also obtained. Results and discussion: This study showed that the sensitivity of the MC-PCR was 0.88 [95% posterior credible interval (PCI 0.80–0.93], which was not significantly different than the SCT, 0.83 (95% PCI 0.76–0.88, which is currently considered as the gold standard. The specificity of both tests was high, 0.98 (95% PCI 0.94–0.99 for the MC-PCR and 0.99 (95% PCI 0.99–1 for the SCT. In a previous study, using fox scats from a low prevalence area, the specificity of the MC-PCR was higher, 0.999% (95% PCI 0.997–1. One reason for the lower estimate of the specificity in this study could be that the MC-PCR detects DNA from infected but non-infectious rodents eaten by foxes. When using MC-PCR in low prevalence areas or areas free from the parasite, a positive result in the MC-PCR should be regarded as a true positive. Conclusion: The sensitivity of the MC-PCR (0.88 was comparable to the sensitivity of SCT (0.83.

  20. OpenMC: a state-of-the-Art Monte Carlo code for research and development

    International Nuclear Information System (INIS)

    Romano, P.K.; Horelik, N.E.; Herman, B.R.; Forget, B.; Smith, K.; Nelson, A.G.

    2013-01-01

    This paper gives an overview of OpenMC, an open source Monte Carlo particle transport code recently developed at the Massachusetts Institute of Technology. OpenMC uses continuous-energy cross sections and a constructive solid geometry representation, enabling high-fidelity modeling of nuclear reactors and other systems. Modern, portable input/output file formats are used in OpenMC: XML for input, and HDF5 for output. High performance parallel algorithms in OpenMC have demonstrated near-linear scaling to over 100,000 processors on modern supercomputers. Other topics discussed in this paper include plotting, CMFD acceleration, variance reduction, eigenvalue calculations, and software development processes. (authors)

  1. A New Approach for Studying Bond Rupture/Closure of a Spiro Benzopyran Photochromic Material: Reactivity Descriptors Derived from Frontier Orbitals and DFT Computed Electrostatic Potential Energy Surface Maps

    Directory of Open Access Journals (Sweden)

    M. S. A. Abdel-Mottaleb

    2016-01-01

    Full Text Available This paper focuses on computations technique within the framework of the TD-DFT theory for studying the relationship between structure-properties of reversible conversion of photochromic materials. Specifically, we report on 1′,3′-dihydro-8-methoxy-1′,3′,3′-trimethyl-6-nitrospiro[2H-1-benzopyran-2,2′-(2H-indole] (SP and its isomers. TD-DFT calculated UV-Vis electronic spectra of the closed and open isomers of this photochromic material are in excellent agreement with the experimental results. Moreover, this paper reports on the results of theoretical investigations of reactivity indices that may govern the conversion between spiropyrans and its isomers. In addition, the solvent and rigidity of the medium significantly control the thermal bleaching of the photogenerated colored isomers and hence the switch ability pattern of the photochromic material. The effect of molecular structure computed by DFT in gas-phase and solvents on Cspiro-O bond length has been shown to correlate with photochromic properties. For this compound, DFT optimized geometry could be used to predict photochromism. Furthermore, in an attempt to predict the driving force for MC → SP, this work explores, for the first time, profitable exploitation of the calculated and visualized mapped electrostatic potential energy surfaces (ESP map. Interestingly, it seems that the electrostatic potential forces over the molecular fragments govern spirobond rupture/closure reactions. Thermodynamically, all-trans-colored isomer (CTT is the most stable merocyanine-like form.

  2. Evidence for the involvement of MC4 receptors in the central mechanisms of opioid antinociception

    NARCIS (Netherlands)

    Starowicz, Katarzyna

    2005-01-01

    The data described in this thesis extend general knowledge of the involvement of the MC4 receptor in mechanisms of analgesia. The following aspects outlined below constitute novel information. Firstly, the MC4R localization in the DRG is demonstrated. The MC4 receptor was assumed to exist

  3. Nancy McCormick Rambusch: A Reflection

    Science.gov (United States)

    Povell, Phyllis

    2005-01-01

    Fall of 2005 marks the 12th anniversary of Nancy McCormick Rambusch's death. As the founder of the American Montessori Society and as its first president, Rambusch reintroduced Maria Montessori to America at a time--1960--when education for the young was floundering, and a second look at the Montessori method, which had changed the early childhood…

  4. Obituary: Martin F. McCarthy (1923-2010)

    Science.gov (United States)

    Coyne, George; Rubin, Vera

    2011-12-01

    Martin F. McCarthy, S.J., astronomer at the Vatican Observatory from 1958 until his retirement in 1999, died peacefully on 5 February at the age of 86 years at the Jesuit Campion Health Center in Weston, Massachusetts where he had resided since his retirement. McCarthy received his doctorate in astronomy from Georgetown University, Washington, DC in 1951. The study of carbon stars, stars whose atmospheres contain more carbon than oxygen, was a major interest for McCarthy. Carbon stars were originally discovered and studied in the 1860s by Fr. Secchi, the eminent Jesuit astronomer. Interestingly, Fr. Secchi spent 1848-50 at Georgetown University in Washington, where Martin McCarthy would receive his PhD degree 101 years later. Upon completion of his seminary studies in theology, he carried out post-doctoral research at Warner and Swasey Observatory, Lick Observatory, the Dominion Astrophysical Observatory and Yerkes Observatory until he began his career at the Vatican Observatory where he served as a key figure in the Observatory's transition to the world of modern research. He also brought the Observatory onto the international stage through his collaborations in research at, among other institutes, Palomar Observatory, Lowell Observatory, Las Campanas Observatories, the Cerro Tololo Interamerican Observatory and the Carnegie Institute of Washington. He served on the Executive Council of the Italian Astronomical Society (1969-1971), was chair of the National Committee of the Vatican to the International Astronomical Union (IAU) from 1979 until his retirement and was President of IAU Commission 25 Stellar Photometry and Polarimetry (1976-1979). During his career he published more than 120 research papers. He was a natural teacher, who enjoyed explaining and talking science to students and visitors. Among his many contributions to the growth of the Vatican Observatory, he was responsible in 1986 for the beginning of the series of the Vatican Observatory Summer

  5. Developing an interface between MCNP and McStas for simulation of neutron moderators

    DEFF Research Database (Denmark)

    Klinkby, Esben Bryndt; Lauritzen, Bent; Nonbøl, Erik

    2012-01-01

    Simulations of target-moderator-reflector system at spallation sources are conventionally carried out using MCNP/X whereas simulations of neutron transport and instrument performance are carried out by neutron ray tracing codes such as McStas. The coupling between the two simulations suites...... typically consists of providing analytical fits from MCNP/X neutron spectra to McStas. This method is generally successful, but as will be discussed in the this paper, there are limitations and a more direct coupling between MCNP/X andMcStas could allow for more accurate simulations of e.g. complex...... moderator geometries, interference between beamlines as well as shielding requirements along the neutron guides. In this paper different possible interfaces between McStas and MCNP/X are discussed and first preliminary performance results are shown....

  6. Genome-Wide Mapping of 5mC and 5hmC Identified Differentially Modified Genomic Regions in Late-Onset Severe Preeclampsia: A Pilot Study.

    Directory of Open Access Journals (Sweden)

    Lisha Zhu

    Full Text Available Preeclampsia (PE is a leading cause of perinatal morbidity and mortality. However, as a common form of PE, the etiology of late-onset PE is elusive. We analyzed 5-methylcytosine (5mC and 5-hydroxymethylcytosine (5hmC levels in the placentas of late-onset severe PE patients (n = 4 and normal controls (n = 4 using a (hydroxymethylated DNA immunoprecipitation approach combined with deep sequencing ([h]MeDIP-seq, and the results were verified by (hMeDIP-qPCR. The most significant differentially methylated regions (DMRs were verified by MassARRAY EppiTYPER in an enlarged sample size (n = 20. Bioinformatics analysis identified 714 peaks of 5mC that were associated with 403 genes and 119 peaks of 5hmC that were associated with 61 genes, thus showing significant differences between the PE patients and the controls (>2-fold, p<0.05. Further, only one gene, PTPRN2, had both 5mC and 5hmC changes in patients. The ErbB signaling pathway was enriched in those 403 genes that had significantly different 5mC level between the groups. This genome-wide mapping of 5mC and 5hmC in late-onset severe PE and normal controls demonstrates that both 5mC and 5hmC play epigenetic roles in the regulation of the disease, but work independently. We reveal the genome-wide mapping of DNA methylation and DNA hydroxymethylation in late-onset PE placentas for the first time, and the identified ErbB signaling pathway and the gene PTPRN2 may be relevant to the epigenetic pathogenesis of late-onset PE.

  7. Bochvar-McCarthy logic and process algebra

    NARCIS (Netherlands)

    Bergstra, J.A.; Ponse, A.

    1998-01-01

    We propose a combination of Bochvar's strict three-valued logic, McCarthy's sequential three-valued logic, and process algebra via the conditional guard construct. This combination entails the introduction of a new constant meaningless in process algebra. We present an operational semantics

  8. Human reliability-based MC and A methods for evaluating the effectiveness of protecting nuclear material - 59379

    International Nuclear Information System (INIS)

    Duran, Felicia A.; Wyss, Gregory D.

    2012-01-01

    Material control and accountability (MC and A) operations that track and account for critical assets at nuclear facilities provide a key protection approach for defeating insider adversaries. MC and A activities, from monitoring to inventory measurements, provide critical information about target materials and define security elements that are useful against insider threats. However, these activities have been difficult to characterize in ways that are compatible with the path analysis methods that are used to systematically evaluate the effectiveness of a site's protection system. The path analysis methodology focuses on a systematic, quantitative evaluation of the physical protection component of the system for potential external threats, and often calculates the probability that the physical protection system (PPS) is effective (PE) in defeating an adversary who uses that attack pathway. In previous work, Dawson and Hester observed that many MC and A activities can be considered a type of sensor system with alarm and assessment capabilities that provide recurring opportunities for 'detecting' the status of critical items. This work has extended that characterization of MC and A activities as probabilistic sensors that are interwoven within each protection layer of the PPS. In addition, MC and A activities have similar characteristics to operator tasks performed in a nuclear power plant (NPP) in that the reliability of these activities depends significantly on human performance. Many of the procedures involve human performance in checking for anomalous conditions. Further characterization of MC and A activities as operational procedures that check the status of critical assets provides a basis for applying human reliability analysis (HRA) models and methods to determine probabilities of detection for MC and A protection elements. This paper will discuss the application of HRA methods used in nuclear power plant probabilistic risk assessments to define detection

  9. McKenzie River focus watershed coordination: year-end report, 2001; ANNUAL

    International Nuclear Information System (INIS)

    Thrailkil, Jim

    2001-01-01

    BPA funding, in conjunction with contributions from numerous partners organizations, supports the McKenzie Watershed Council's efforts to coordinate restoration and monitoring programs of federal, state, local government, and residents within the watershed. The goal of the MWC is to improve resource stewardship and conserve fish, wildlife, and water quality resources. The MWC will always have a baseline program centered on relationship building and information sharing. Objectives for FY01 included: (1) Continue to coordinate McKenzie Watershed activities among diverse groups that restore fish and wildlife habitat in the watershed, with a focus on the lower McKenzie, including private lands and the McKenzie-Willamette confluence area; (2) Influence behavior of watershed residents to benefit watershed function though a strategic and comprehensive outreach and education program, utilizing Assessment and Conservation Strategy information to provide a context for prioritized action; (3) Continue to maintain and sustain a highly functional watershed council; (4) Maintain and improve water quality concerns through the continuation of Council-sponsored monitoring and evaluation programs; and (5) Continue to secure other funding for watershed restoration and protection projects and Council operations

  10. McStas 1.1: A tool for building neutron Monte Carlo simulations

    DEFF Research Database (Denmark)

    Lefmann, K.; Nielsen, K.; Tennant, D.A.

    2000-01-01

    McStas is a project to develop general tools for the creation of simulations of neutron scattering experiments. In this paper, we briefly introduce McStas and describe a particular application of the program: the Monte Carlo calculation of the resolution function of a standard triple-axis neutron...

  11. Occurrences of dendritic gold at the McLaughlin Mine hot-spring gold deposit

    Science.gov (United States)

    Sherlock, R. L.; Lehrman, N. J.

    1995-06-01

    Two styles of gold dendrites are variably developed at the McLaughlin Mine. The most abundant occurrence is hosted by amber-coloured hydrocarbon-rich opal. Silica likely precipitated from a boiling hydrothermal fluid and complexed with immiscible hydrocarbons forming an amorphous hydrocarbon-silica phase. This phase likely scavenged particulate gold by electrostatic attraction to the hydrocarbon-silica phase. The dendritic nature of the gold is secondary and is the result of dewatering of the amorphous hydrocarbon-silica phase and crystallization of gold into syneresis fractures. The second style of dendritic gold is hosted within vein swarms that focused large volumes of fluid flow. The dendrites occur along with hydrocarbon-rich silica at the upper contact of the vein margins which isolated the dendrites allowing sufficient time for them to grow. In a manner similar to the amber-coloured opal, the dendrites may have formed by scavenging particulate gold by electrostatic attraction to the hydrocarbon-silica phase.

  12. OpenMC In Situ Source Convergence Detection

    Energy Technology Data Exchange (ETDEWEB)

    Aldrich, Garrett Allen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Univ. of California, Davis, CA (United States); Dutta, Soumya [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); The Ohio State Univ., Columbus, OH (United States); Woodring, Jonathan Lee [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-05-07

    We designed and implemented an in situ version of particle source convergence for the OpenMC particle transport simulator. OpenMC is a Monte Carlo based-particle simulator for neutron criticality calculations. For the transport simulation to be accurate, source particles must converge on a spatial distribution. Typically, convergence is obtained by iterating the simulation by a user-settable, fixed number of steps, and it is assumed that convergence is achieved. We instead implement a method to detect convergence, using the stochastic oscillator for identifying convergence of source particles based on their accumulated Shannon Entropy. Using our in situ convergence detection, we are able to detect and begin tallying results for the full simulation once the proper source distribution has been confirmed. Our method ensures that the simulation is not started too early, by a user setting too optimistic parameters, or too late, by setting too conservative a parameter.

  13. Completing Einstein's Proof of E=mc2

    Directory of Open Access Journals (Sweden)

    Lo C. Y.

    2006-10-01

    Full Text Available It is shown that Einstein’s proof for E=mc2 is actually incomplete and therefore is not yet valid. A crucial step is his implicit assumption of treating the light as a bundle of massless particles. However, the energy-stress tensor of massless particles is incompatible with an electromagnetic energy-stress tensor. Thus, it is necessary to show that the total energy of a light ray includes also non-electromagnetic energy. It turns out, the existence of intrinsic difference between the photonic and the electromagnetic energy tensors is independent of the coupling of gravity. Nevertheless, their difference is the energy-stress tensor of the gravitational wave component that is accompanying the electromagnetic wave component. Concurrently, it is concluded that Einstein’s formula E=mc2 necessarily implies that the photons include non- electromagnetic energy and that the Einstein equation of 1915 must be rectified.

  14. The effects of McKenzie and Brunkow exercise program on spinal mobility comparative study

    Directory of Open Access Journals (Sweden)

    Emela Mujić Skikić

    2004-02-01

    Full Text Available This study encompassed 64 participants with symptoms of low back pain, 33 in McKenzie group and 31 in Brunkow group. Patients attended exercise program daily and they were asked to do the same exercise at home--five times a day in series of 5 to 10 repetition each time, depending of stage of disease and pain intensity. All patients were assessed for the spinal motion, before and after the treatment. All parameters for spinal movements showed improvement after exercising McKenzie program for lower back pain with a significant difference of p<0.01 for all motions. Also, in Brunkow group, all of the parameters showed statistically significant improvement at the end of treatment in relation to pre-treatment values, with significant difference of p<0.01 for all motions. Statistically comparison between McKenzie and Brunkow difference in score at the end of the treatment showed statistically significant improvement in McKenzie group, for extension, right and left side flexion, while flexion score didn't show statistically significant difference. McKenzie exercises seemed to be more effective than Brunkow exercises for improvement in spinal motion. Both, McKenzie and Brunkow exercises can be used for spinal mobility improvement in patients with lower back pain, but is preferable to use McKenzie exercises first, to decrease the pain and increase spinal mobility, and then Brunkow exercises to strengthen the paravertebral muscles.

  15. Novel MC/BZY Proton Conductor: Materials Development, Device Evaluation, and Theoretical Exploration using CI and DFT Methods

    Science.gov (United States)

    2017-09-05

    the protons produced by surface defect reactions were transferred to the neighboring carbonate-ions ( CO3 2-) at the BZY/MC interface to form HCO3...static DFT study of the proton transfer in the crystal structure of lithium carbonate 33. The calculated energy barrier was 0.34 eV along the...However, the value is only 20.5 kcal/mol in Ref. 33, which was calculated based on a single molecule of HCO3 -. To eliminate possible uncertainty in the

  16. McArthur-Bates Communicative Development Inventory (CDI: Proposal of an abbreviate version

    Directory of Open Access Journals (Sweden)

    Chamarrita Farkas Klein

    2011-01-01

    Full Text Available The McArthur-Bates Communicative Development Inventories (CDI assesses language development en children, through a significant caregiver report. The first inventory assesses verbal and non verbal language in infants who are from 8 to 18 months old and it is composed of 949 items distributed in 6 scales. This study proposes an abbreviate form of this instrument, and was tested on families and educators of 130 Chilean children of 11-15 months old. Analyses related to the items, reliability and validity of the instrument and factorial analyses of subscales were realized. The abbreviate version consider 241 items distributed in 4 scales. The evaluation of the psychometric properties of the instrument was acceptable, demonstrating adequate reliability and validity.

  17. Ms. Rodriquez and Mickey Mouse pose with a portrait of Ronald McNair

    Science.gov (United States)

    1999-01-01

    In the gymnasium of Ronald McNair Magnet School in Cocoa, Fla., Ms. Maria Rodriguez, an Walt Disney World Ambassador, and Mickey Mouse pose with a portrait of NASA astronaut Ronald McNair. The portrait was presented to the school by Walt Disney World during a tribute to McNair. The school had previously been renamed for the fallen astronaut, who was one of a crew of seven who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

  18. Perubahan Format dan Desain Surat Kabar Indonesia dalam Perspektif “McJournalism”

    Directory of Open Access Journals (Sweden)

    Awang Ruswandi

    2006-12-01

    Full Text Available The changing of newspapers format and design in Indonesia become a prominence phenomenon in recent times. When Kompas, a national leading newspaper in Indonesia, changed its format and design, it was sufficiently enough to claim that McJournalism phenomenon started to appear in Indonesia. McJournalism, adopted by Bob Franklin from Ritzer’s famous term “McDonaldization,” consisted of four characteristic: efficiency, calculability, predictability, and control. An analysis to such changes on some Indonesian major newspaper formats and designs have proven that the policy led also to the changing of mechanisms and working routines in those newspapers as well.

  19. McIsaac criteria for diagnosis of acute group-A β-hemolytic streptococcal pharyngitis

    Directory of Open Access Journals (Sweden)

    Imanuel Y. Malino

    2013-10-01

    Conclusion A McIsaac criteria total score of <4 is favorable for excluding a diagnosis of GABHS pharyngitis. A McIsaac total criteria score of ≥4 requires further examination to confirm a diagnosis of GABHS pharyngitis.

  20. M&C ML: A modeling language for monitoring and control systems

    Energy Technology Data Exchange (ETDEWEB)

    Patwari, Puneet, E-mail: patwari.puneet@tcs.com; Chaudhuri, Subhrojyoti Roy; Natarajan, Swaminathan; Muralikrishna, G

    2016-11-15

    Highlights: • It is challenging to maintain consistency in the current approach to M&C design. • Based on similarity across various projects, it looks ideal to propose a solution at domain level. • Approach to create a DSL for M&C involves viewing a system through lenses of various domains. • M&CML provides a standard vocabulary and the entire process of M&C solution creation domain-aware. • M&CML provides a holistic view of control architecture. • M&CML has support for inherent consistency checks, user assistance and third party support. - Abstract: The use of System Engineering (SE) language such as SysML [1,20] is common within the community of control system designers. However the design handoff to the subsequent phases of the control system development is carried out manually in most cases without much tool support. The approach to agreeing on the control interface between components is a good example where engineers still rely on either manually created Interface Control Documents (ICD) or one off tools implemented by individual projects. Square Kilometer Array (SKA) [2] and International Thermonuclear Experimental Reactor (ITER) [3] are two good examples of such large projects adopting these approaches. This results in non-uniformity in the overall system design since individual groups invent their own vocabulary while using a language like SysML which leads to inconsistencies across the design, interface and realized code. To mitigate this, we propose the development of a Monitoring and Control Modeling Language (M&CML), a domain specific language (DSL) [4,22] for specifying M&C solutions. M&C ML starts with defining a vocabulary borrowing concepts from standard practices used in the control domain and incorporates a language which ensures uniformity and consistency across the M&C design, interfaces and implementation artifacts. In this paper we discuss this language with an analysis of its usage to point out its benefits.

  1. M&C ML: A modeling language for monitoring and control systems

    International Nuclear Information System (INIS)

    Patwari, Puneet; Chaudhuri, Subhrojyoti Roy; Natarajan, Swaminathan; Muralikrishna, G

    2016-01-01

    Highlights: • It is challenging to maintain consistency in the current approach to M&C design. • Based on similarity across various projects, it looks ideal to propose a solution at domain level. • Approach to create a DSL for M&C involves viewing a system through lenses of various domains. • M&CML provides a standard vocabulary and the entire process of M&C solution creation domain-aware. • M&CML provides a holistic view of control architecture. • M&CML has support for inherent consistency checks, user assistance and third party support. - Abstract: The use of System Engineering (SE) language such as SysML [1,20] is common within the community of control system designers. However the design handoff to the subsequent phases of the control system development is carried out manually in most cases without much tool support. The approach to agreeing on the control interface between components is a good example where engineers still rely on either manually created Interface Control Documents (ICD) or one off tools implemented by individual projects. Square Kilometer Array (SKA) [2] and International Thermonuclear Experimental Reactor (ITER) [3] are two good examples of such large projects adopting these approaches. This results in non-uniformity in the overall system design since individual groups invent their own vocabulary while using a language like SysML which leads to inconsistencies across the design, interface and realized code. To mitigate this, we propose the development of a Monitoring and Control Modeling Language (M&CML), a domain specific language (DSL) [4,22] for specifying M&C solutions. M&C ML starts with defining a vocabulary borrowing concepts from standard practices used in the control domain and incorporates a language which ensures uniformity and consistency across the M&C design, interfaces and implementation artifacts. In this paper we discuss this language with an analysis of its usage to point out its benefits.

  2. Evaluation of the 2010 McDonald multiple sclerosis criteria in children with a clinically isolated syndrome.

    Science.gov (United States)

    Kornek, Barbara; Schmitl, Beate; Vass, Karl; Zehetmayer, Sonja; Pritsch, Martin; Penzien, Johann; Karenfort, Michael; Blaschek, Astrid; Seidl, Rainer; Prayer, Daniela; Rostasy, Kevin

    2012-12-01

    Magnetic resonance imaging diagnostic criteria for paediatric multiple sclerosis have been established on the basis of brain imaging findings alone. The 2010 McDonald criteria for the diagnosis of multiple sclerosis, however, include spinal cord imaging for detection of lesion dissemination in space. The new criteria have been recommended in paediatric multiple sclerosis. (1) To evaluate the 2010 McDonald multiple sclerosis criteria in children with a clinically isolated syndrome and to compare them with recently proposed magnetic resonance criteria for children; (2) to assess whether the inclusion of spinal cord imaging provided additional value to the 2010 McDonald criteria. We performed a retrospective analysis of brain and spinal cord magnetic resonance imaging scans from 52 children with a clinically isolated syndrome. Sensitivity, specificity and accuracy of the magnetic resonance criteria were assessed. The 2010 McDonald dissemination in space criteria were more sensitive (85% versus 74%) but less specific (80% versus 100%) compared to the 2005 McDonald criteria. The Callen criteria were more accurate (89%) compared to the 2010 McDonald (85%), the 2005 McDonald criteria for dissemination in space (81%), the KIDMUS criteria (46%) and the Canadian Pediatric Demyelinating Disease Network criteria (76%). The 2010 McDonald criteria for dissemination in time were more accurate (93%) than the dissemination in space criteria (85%). Inclusion of the spinal cord did not increase the accuracy of the McDonald criteria.

  3. McDonaldizing Spirituality: Mindfulness, Education, and Consumerism

    Science.gov (United States)

    Hyland, Terry

    2017-01-01

    The exponential growth of mindfulness-based interventions (MBIs) in recent years has resulted in a marketisation and commodification of practice--popularly labeled "McMindfulness"--which divorces mindfulness from its spiritual and ethical origins in Buddhist traditions. Such commodification is criticized by utilising ideas and insights…

  4. Claude McKay between United States and Soviet Union: African-American Identity and Socialist Utopia

    Directory of Open Access Journals (Sweden)

    Fiorenzo Iuliano

    2016-04-01

    Full Text Available This article analyzes Claude McKay’s essays on politics and society, especially those dealing with the racial question in the 1920s US. It reviews these texts, alongside other works (poems and autobiographical writings that McKay produced on the same topics. The article aims at tracing a trajectory in McKay’s political thought: after criticizing the social and economic structures of capitalist and colonial societies, McKay envisages in post-revolutionary USSR a utopian society for oppressed people worldwide. However, his writings, rather than depicting the actual USSR society he knew in the early 1920s, evokes the multicultural myth of the ‘melting pot’ traditionally used to celebrate the US. McKay, maybe unwillingly, enthusiastically praises the myth of American exceptionalism, referring it to the USSR.

  5. Developing standard performance testing procedures for MC and A components at a site

    International Nuclear Information System (INIS)

    Scherer, Carolynn

    2010-01-01

    The condition of a nuclear material control and accountability system (MC and A) and its individual components, as with any system combining technical elements, documentation and the human factor, may be characterized through an aggregate of values for the various parameters that determine the system's ability to perform. The MC and A system's status may be functioning effectively, marginally or not functioning based on a summary of the values of the individual parameters. This work included a review of the following elements and subsystems or components for a material control and accountability system: (1) MC and A Elements: Information subsystem, Measurement subsystem, NM access subsystem, including a tamper-indicating device (TID) program, and Automated information-gathering subsystem; and (2) Detecting NM Loses Elements: Inventory differences, Shipper/receiver differences, Confirmatory measurements and differences with accounting data, and TID or seal violations. In order to detect the absence or loss of nuclear material there must be appropriate interactions among the elements and their respective subsystems (from the list above). Additionally this work includes a review of the status of regulatory requirements for the MC and A system components and potential criteria that support the evaluation of the performance of the listed components. The listed components had performance testing algorithms and procedures developed that took into consideration the regulatory criteria. The developed MC and A performance-testing procedures were the basis for a pilot Guide for MC and A Performance Testing at the MBAs of SSC RF IPPE.

  6. Review and Synthesis of Evidence Regarding Environmental Risks Posed by Munitions Constituents (MC) in Aquatic Systems

    Science.gov (United States)

    2017-10-31

    the ingestion of contaminated sediment and food items that have accumulated MC in their tissues. Because MCs are poorly accumulated in fish and...explosives have been extensively used by the DoD. Contamination of terrestrial sites by MC has occurred largely due to (1) explosive manufacturing ...varied widely across a diversity of MC and species. For most aquatic sites, MC contamination in sediment and in the water- column presents low risk to

  7. Reading the Anthropocene through science and apocalypse in the selected contemporary fiction of J.G. Ballard, Kurt Vonnegut, Cormac McCarthy and Ian McEwan

    OpenAIRE

    Fevyer, David

    2016-01-01

    This thesis examines how six contemporary novels variously intervene in the current crisis of climate change. Through close readings of J G Ballard’s The Drowned World (1962) and Hello America (1981); Cormac McCarthy’s The Road (2006); Kurt Vonnegut’s Cat’s Cradle (1963) and Galapagos (1985); and Ian McEwan’s Solar (2010), the thesis aims to identify how the narrative and generic resources of contemporary fiction might help readers to think through and beyond the consequences of anthropocentr...

  8. Validation of a culturally modified short form of the McCarthy Scales of Children’s Abilities in 6 to 8 year old Zimbabwean school children: a cross section study

    Directory of Open Access Journals (Sweden)

    Kandawasvika Gwendoline Q

    2012-11-01

    Full Text Available Abstract Background The burden of cognitive impairment among school children from developing communities is under reported due to lack of culturally appropriate screening tools. The objective of this study was to validate a culturally modified short form of the McCarthy Scales of Children Abilities (MSCA in school children aged 6–8 years from varied backgrounds. Methods One hundred and one children aged 6–8 years attending mainstream classes were enrolled cross-sectionally from three schools: one rural and two urban. Two assessments were conducted on each child and the Short form MSCA was compared to an independent assessment by the educational psychologist. Results When comparing the results of the MSCA to local standard at -2SD, -1.5 SD and -1SD the sensitivity rates ranged from 17 to 50% with lower sensitivity at -2SD cut-off point. Specificity rates had less variation ranging from 95% to 100%. The number of children identified with cognitive impairment using -2SD, -1.5SD and -1SD below the mean for MSCA as a cut-off point were 3(3%, 7(7% and 13(13% respectively while the psychologist identified 18 (18%. The overall mean score on MSCA was 103 (SD 15. The rural children tended to score significantly lower marks compared to their peers from urban areas, mean (SD 98(15 and 107(15 respectively, p=0.006. There was no difference in the mean (SD scores between boys and girls, 103(17 and 103(15 respectively, p=0.995. Conclusion The culturally modified short form MSCA showed high specificity but low sensitivity. Prevalence of cognitive impairment among 6 to 8 year children was 3%. This figure is high when compared to developed communities.

  9. McCainiga hakkab rinda pistma Obama / Hendrik Vosman

    Index Scriptorium Estoniae

    Vosman, Hendrik

    2008-01-01

    USA demokraatide presidendikandidaat Hillary Clinton ei söandanud oma allajäämist Barack Obamale tunnistada. Lisa: Obama ja McCaini seisukohad. Vt. samas: Hillary Clinton võib saada asepresidendi kandidaadiks

  10. 77 FR 52264 - Airworthiness Directives; Hughes Helicopters, Inc., and McDonnell Douglas Helicopter Systems...

    Science.gov (United States)

    2012-08-29

    ... Airworthiness Directives; Hughes Helicopters, Inc., and McDonnell Douglas Helicopter Systems (Type Certificate... Airworthiness Directive (AD): Hughes Helicopters Inc., and McDonnel Douglas Helicopter Systems (Type Certificate...

  11. Light-responsive micelles of spiropyran initiated hyperbranched polyglycerol for smart drug delivery.

    Science.gov (United States)

    Son, Suhyun; Shin, Eeseul; Kim, Byeong-Su

    2014-02-10

    Light-responsive polymeric micelles have emerged as site-specific and time-controlled systems for advanced drug delivery. Spiropyran (SP), a well-known photochromic molecule, was used to initiate the ring-opening multibranching polymerization of glycidol to afford a series of hyperbranched polyglycerols (SP-hb-PG). The micelle assembly and disassembly were induced by an external light source owing to the reversible photoisomerization of hydrophobic SP to hydrophilic merocyanine (MC). Transmission electron microscopy, atomic force microscopy, UV/vis spectroscopy, and dynamic light scattering demonstrated the successful assembly and disassembly of SP-hb-PG micelles. In addition, the critical micelle concentration (CMC) was determined through the fluorescence analysis of pyrene to confirm the amphiphilicity of respective SP-hb-PGn (n = 15, 29, and 36) micelles, with CMC values ranging from 13 to 20 mg/L, which is correlated to the length of the polar polyglycerol backbone. Moreover, the superior biocompatibility of the prepared SP-hb-PG was evaluated using WI-38 cells and HeLa cells, suggesting the prospective applicability of the micelles in smart drug delivery systems.

  12. DAT by perceived MC interaction on human prefrontal activity and connectivity during emotion processing.

    Science.gov (United States)

    Taurisano, Paolo; Blasi, Giuseppe; Romano, Raffaella; Sambataro, Fabio; Fazio, Leonardo; Gelao, Barbara; Ursini, Gianluca; Lo Bianco, Luciana; Di Giorgio, Annabella; Ferrante, Francesca; Papazacharias, Apostolos; Porcelli, Annamaria; Sinibaldi, Lorenzo; Popolizio, Teresa; Bertolino, Alessandro

    2013-12-01

    Maternal care (MC) and dopamine modulate brain activity during emotion processing in inferior frontal gyrus (IFG), striatum and amygdala. Reuptake of dopamine from the synapse is performed by the dopamine transporter (DAT), whose abundance is predicted by variation in its gene (DAT 3'VNTR; 10 > 9-repeat alleles). Here, we investigated the interaction between perceived MC and DAT 3'VNTR genotype on brain activity during processing of aversive facial emotional stimuli. Sixty-one healthy subjects were genotyped for DAT 3'VNTR and categorized in low and high MC individuals. They underwent functional magnetic resonance imaging while performing a task requiring gender discrimination of facial stimuli with angry, fearful or neutral expressions. An interaction between facial expression, DAT genotype and MC was found in left IFG, such that low MC and homozygosity for the 10-repeat allele are associated with greater activity during processing of fearful faces. This greater activity was also inversely correlated with a measure of emotion control as scored with the Big Five Questionnaire. Moreover, MC and DAT genotype described a double dissociation on functional connectivity between IFG and amygdala. These findings suggest that perceived early parental bonding may interact with DAT 3'VNTR genotype in modulating brain activity during emotionally relevant inputs.

  13. Scintigraphic demonstration of a iatrogenic rhabdomyolysis im McArdle's syndrome

    International Nuclear Information System (INIS)

    Neumann, P.; Rumpf, K.W.; Kaiser, H.; Meinck, H.M.; Goebel, H.H.; Schicha, H.; Emrich, D.; Goettingen Univ.; Goettingen Univ.; Goettingen Univ.; Goettingen Univ.

    1982-01-01

    In a patient with late onset McArdle's disease local rhabdomyolysis and massive myoglobinuria were provoked by a routine diagnostic procedure - the forearm ischemic work test. Localisation and extent of rhabdomyolysis could be demonstrated by a conventional whole-body scanning technique using sup(99m)Tc methylenediphosphonate as a tracer. It is concluded that the forearm ischemic work test is not without risk in patients with McArdle's disease, and care should be taken to prevent myoglobinuric renal failure in these patients. (orig.) [de

  14. 78 FR 18226 - Airworthiness Directives; Hughes Helicopters, Inc., and McDonnell Douglas Helicopter Systems...

    Science.gov (United States)

    2013-03-26

    ... Airworthiness Directives; Hughes Helicopters, Inc., and McDonnell Douglas Helicopter Systems (Type Certificate... directive (AD): 2013-05-16 Hughes Helicopters, Inc., and McDonnell Douglas Helicopter Systems (Type...

  15. The Limitations of Behavior-Genetic Analyses: Comment on McGue, Elkins, Walden, and Iacono (2005)

    Science.gov (United States)

    Greenberg, Gary

    2005-01-01

    This article takes issue with the behavior-genetic analysis of parenting style presented by M. McGue, I. Elkins, B. Walden, and W. G. Iacono. The author argues that the attribution of their findings to inherited genetic effects was without basis because McGue et al. never indicated how those genetic effects manifested themselves. Instead, McGue et…

  16. 49 CFR 178.318 - Specification MC 201; container for detonators and percussion caps.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Specification MC 201; container for detonators and percussion caps. 178.318 Section 178.318 Transportation Other Regulations Relating to Transportation PIPELINE....318 Specification MC 201; container for detonators and percussion caps. ...

  17. Individual differences and the effect of face configuration information in the McGurk effect.

    Science.gov (United States)

    Ujiie, Yuta; Asai, Tomohisa; Wakabayashi, Akio

    2018-04-01

    The McGurk effect, which denotes the influence of visual information on audiovisual speech perception, is less frequently observed in individuals with autism spectrum disorder (ASD) compared to those without it; the reason for this remains unclear. Several studies have suggested that facial configuration context might play a role in this difference. More specifically, people with ASD show a local processing bias for faces-that is, they process global face information to a lesser extent. This study examined the role of facial configuration context in the McGurk effect in 46 healthy students. Adopting an analogue approach using the Autism-Spectrum Quotient (AQ), we sought to determine whether this facial configuration context is crucial to previously observed reductions in the McGurk effect in people with ASD. Lip-reading and audiovisual syllable identification tasks were assessed via presentation of upright normal, inverted normal, upright Thatcher-type, and inverted Thatcher-type faces. When the Thatcher-type face was presented, perceivers were found to be sensitive to the misoriented facial characteristics, causing them to perceive a weaker McGurk effect than when the normal face was presented (this is known as the McThatcher effect). Additionally, the McGurk effect was weaker in individuals with high AQ scores than in those with low AQ scores in the incongruent audiovisual condition, regardless of their ability to read lips or process facial configuration contexts. Our findings, therefore, do not support the assumption that individuals with ASD show a weaker McGurk effect due to a difficulty in processing facial configuration context.

  18. LANGUAGE FORM AND FUNCTION OF CARETAKERS FOUND IN NANNY MCPHEE AND THE BIG BANG MOVIE

    Directory of Open Access Journals (Sweden)

    Aditya Putri Kusuma Andani

    2016-02-01

    Full Text Available This study deals with the form and the function of caretaker speech which is found in caretaker’s utterance in Nanny McPhee and The Big Bang Movie. The objectives of this study are (1 to describe the type of language form of the caretaker and (2 to describe the type of language function of the caretaker found in Nanny McPhee and The Big Bang Movie. The type of this research is descriptive qualitative research. The data of this research are the utterance from the caretaker found in manuscript of Nanny McPhee and The Big Bang Movie. The data collection technique is documentation. The technique of analyzing data are descriptive qualitative. The writer uses the theories from Frank (1972 to analyze the type of language form, and M.A.K. Halliday (1977 to analyze the type of language function. The result of this study shows that (1 there are four types of word: noun, verb, adjective, and adverb; three types of phrase: noun phrase, verb phrase, and adverb phrase; and two types of sentence categorized into two. The first category is based on type, namely: declarative, imperative, interrogative, and exclamatory sentence; the second one by number of full predication, namely: simple, compound, complex, and compound-complex sentence. (2 The writer found 6 types of language function, they are: regulatory function, instrumental function, representational function, personal function, interactional function, and imaginative function.

  19. The Growth of Protein Crystals Using McDUCK

    Science.gov (United States)

    Ewing, Felicia; Wilson, Lori; Nadarajah, Arunan; Pusey, Marc

    1998-01-01

    Most of the current microgravity crystal growth hardware is optimized to produce crystals within the limited time available on orbit. This often results in the actual nucleation and growth process being rushed or the system not coming to equilibrium within the limited time available. Longer duration hardware exists, but one cannot readily pick out crystals grown early versus those which nucleated and grew more slowly. We have devised a long duration apparatus, the Multi-chamber Dialysis Unit for Crystallization Kinetics, or McDUCK. This apparatus-is a series of protein chambers, stacked upon a precipitant reservoir chamber. All chambers are separated by a dialysis membrane, which serves to pass small molecules while retaining the protein. The volume of the Precipitant chamber is equal to the sum of the volumes of the protein chamber. In operation, the appropriate chambers are filled with precipitant solution or protein solution, and the McDUCK is placed standing upright, with the precipitant chamber on the bottom. The precipitant diffuses upwards over time, with the time to reach equilibration a function of the diffusivity of the precipitant and the overall length of the diffusion pathway. Typical equilibration times are approximately 2-4 months, and one can readily separate rapid from slow nucleation and growth crystals. An advantage on Earth is that the vertical precipitant concentration gradient dominates that of the solute, thus dampening out solute density gradient driven convective flows. However, large Earth-grown crystals have so far tended to be more two dimensional. Preliminary X-ray diffraction analysis of lysozyme crystals grown in McDUCK have indicated that the best, and largest, come from the middle chambers, suggesting that there is an optimal growth rate. Further, the improvements in diffraction resolution have been better signal to noise ratios in the low resolution data, not an increase in resolution overall. Due to the persistently large crystals

  20. Degradation of corn stalk by the composite microbial system of MC1

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The composite microbial system of MC1 was used to degrade corn stalk in order to determine properties of the degraded products as well as bacterial composition of MC1. Results indicated that the pH of the fermentation broth was typical of lignocellulose degradatioin by MC1, decreasing in the early phase and increasing in later stages of the degradation. The microbial biomass peaked on the day 3 after degradation. The MC1 effeciently degraded the corn stalk by nearly 70% during which its cellulose content decreased by 71.2%, hemicellulose by 76.5% and lignin by 24.6%. The content of water-soluble carbohydrates (WSC) in the fermentation broth increased progressively during the first three days, and decreased thereafter, suggesting an accumulation of WSC in the early phase of the degradation process. Total levels of various volatile products peaked in the third day after degradation , and 7 types of volatile products were detected in the fermentation broth. These were ethanol, acetic acid, 1,2-ethanediol, propanoic acid, butanoic acid, 3-methyl-butanoic acid and glycerine. Six major compounds were quantitatively analysed and the contents of each compound were ethanol (0.584 g/L), acetic acid (0.735 g/L), 1,2-ethanediol (0.772 g/L), propanoic acid (0.026 g/L), butanoic acid (0.018 g/L) and glycerine (4.203 g/L). Characterization of bacterial cells collected from the culture solution, based on 16S rDNA PCR-DGGE analysis of DNAs, showed that the composition of bacterial community in MC1 coincided basically with observations from previous studies. This indicated that the structure of MC1 is very stable during degradation of different lignocellulose materials.

  1. Oral manifestations of McCune-Albright syndrome

    Directory of Open Access Journals (Sweden)

    Konidena Aravinda

    2013-01-01

    Full Text Available McCune- Albright Syndrome (MAS is a rare fibrosseous lesion, characterized by a classic triad of polyostotic fibrous dysplasia (PFD, cafι -au-lait macules (CALM and underlying endocrinopathies. We present the oral findings of an interesting case of MAS with relevant review of literature. A 30-year-old male presented to us with swelling of both jaws over a period of two years. Cutaneous examination revealed cafι - au - lait macule over the back, crossing the midline. Skeletal survey showed expansile, osteolytic, mixed radiolucent- radiopaque lesions in skull and jaw bones. Serum alkaline phosphatase was elevated (388 IU/L, with normal calcium, phosphorus, parathyroid hormone and 25 hydroxy vitamin D levels. Diagnosis of McCune- Albright syndrome was made and he was treated with parenteral bisphosphonates (intravenous Zoledronate 4 mg and is under follow up for surgical recontouring of the jaws. Early recognition facilitates better treatment and improves prognosis by reducing the morbidity.

  2. Development, validation, and factorial comparison of the McGill Self-Efficacy of Learners For Inquiry Engagement (McSELFIE) survey in natural science disciplines

    Science.gov (United States)

    Ibrahim, Ahmed; Aulls, Mark W.; Shore, Bruce M.

    2016-11-01

    Sociocognitive theory [Bandura, A. (1986). Social foundations of thought and action: A social cognitive theory. Englewood Cliffs, NJ: Prentice Hall; Bandura, A. (1989). Human agency in social cognitive theory. American Psychologist, 44, 1175-1184. doi:10.1037/0003-066x.44.9.1175; Bandura, A. (1991). Social cognitive theory of self-regulation. Organizational Behavior and Human Decision Processes, 50, 248-287. doi:10.1016/0749-5978(91)90022-L] accords high importance to the mechanisms of human agency and how they are exercised through self-efficacy. In this paper, we developed and validated the McGill Self-Efficacy For Inquiry Engagement (McSELFIE) instrument with undergraduate students in natural science disciplines. We defined inquiry engagement as carrying out the practices of science (POS) that are supported by students' personality characteristics (SPCs) and that result in achieving inquiry-learning outcomes (ILOs). Based on these theoretical perspectives, the McSELFIE is a 60-item, learner-focused survey that addresses three components that are theoretically important for engaging in scientific inquiry: (a) SPCs, (b) ILOs, and (c) POS. Evidence for construct and content validity were obtained by using experts' judgments and confirmatory factor analysis with a sample of 110 undergraduate students enrolled in science disciplines. Internal consistency of the factors and instrument was also examined. The McSELFIE instrument is a reliable and valid instrument for measuring science undergraduate students' self-efficacy for inquiry engagement. Matched pairs analyses were conducted among the instruments' factors. Students reported the highest self-efficacy for openness, applying knowledge, and carrying out investigations. Students reported the lowest self-efficacy for extraversion, understanding metacognitive knowledge, and planning investigations. Theoretical and practical implications are discussed.

  3. McDonald's restaurants and neighborhood deprivation in Scotland and England.

    Science.gov (United States)

    Cummins, Steven C J; McKay, Laura; MacIntyre, Sally

    2005-11-01

    Features of the local fast food environment have been hypothesized to contribute to the greater prevalence of obesity in deprived neighborhoods. However, few studies have investigated whether fast food outlets are more likely to be found in poorer areas, and those that have are local case studies. In this paper, using national-level data, we examine the association between neighborhood deprivation and the density of McDonald's restaurants in small census areas (neighborhoods) in Scotland and England. Data on population, deprivation, and the location of McDonald's Restaurants were obtained for 38,987 small areas in Scotland and England (6505 "data zones" in Scotland, and 32,482 "super output areas" in England) in January 2005. Measures of McDonald's restaurants per 1000 people for each area were calculated, and areas were divided into quintiles of deprivation. Associations between neighborhood deprivation and outlet density were examined during February 2005, using one-way analysis of variance in Scotland, England, and both countries combined. Statistically significant positive associations were found between neighborhood deprivation and the mean number of McDonald's outlets per 1000 people for Scotland (p<0.001), England (p<0.001), and both countries combined (p<0.001). These associations were broadly linear with greater mean numbers of outlets per 1000 people occurring as deprivation levels increased. Observed associations between presence or absence of fast food outlets and neighborhood deprivation may provide support for environmental explanations for the higher prevalence of obesity in poor neighborhoods.

  4. Acquisition of wood fuel at the Joseph C. McNeil Generating Station

    Energy Technology Data Exchange (ETDEWEB)

    Kropelin, W. [Burlington Electric Dept., VT (United States)

    1993-12-31

    The Joseph C. McNeil Generating Station is the world`s largest single boiler, municipally-owned, wood-fired electrical generating plant. The 50 megawatt McNeil Station is located in Burlington, Vermont and is owned by several Vermont public and private electric utilities. The operator and majority owner is the City of Burlington Electric Department (BED). Wood fuel procurement for the McNeil Station has been conducted in an environmentally sensitive way. Harvesting is carried out in conformance with a comprehensive wood chip harvesting policy and monitored by professional foresters. Unpredictable levels of Station operation require rigid adherence to a wood storage plan that minimizes the risk of over heating and spontaneous combustion of stockpiled fuel.

  5. Spectroscopic Profiles of Comets Garradd and McNaught

    Science.gov (United States)

    Harris, Ien; Pierce, Donna M.; Cochran, Anita L.

    2017-10-01

    We have used the integral-field unit spectrograph (the George and Cynthia Mitchell Spectrograph) on the 2.7m Harlan J. Smith telescope at McDonald Observatory to obtain spectroscopic images of the comae of several comets. The images were obtained for various radical species (C2, C3, CN, NH2). Radial and azimuthal average profiles of the radical species were created to enhance any observed cometary coma morphological features. We compare the observed coma features across the observed species and over the different observation periods in order to constrain possible rotational states of the observed comets, as well as determine possible source differences in the coma between the observed radical species. We will present results for several comets, including C/2009 P1 (Garradd) and 260P (McNaught).

  6. Probabilistic programming in Python using PyMC3

    Directory of Open Access Journals (Sweden)

    John Salvatier

    2016-04-01

    Full Text Available Probabilistic programming allows for automatic Bayesian inference on user-defined probabilistic models. Recent advances in Markov chain Monte Carlo (MCMC sampling allow inference on increasingly complex models. This class of MCMC, known as Hamiltonian Monte Carlo, requires gradient information which is often not readily available. PyMC3 is a new open source probabilistic programming framework written in Python that uses Theano to compute gradients via automatic differentiation as well as compile probabilistic programs on-the-fly to C for increased speed. Contrary to other probabilistic programming languages, PyMC3 allows model specification directly in Python code. The lack of a domain specific language allows for great flexibility and direct interaction with the model. This paper is a tutorial-style introduction to this software package.

  7. Fluvial to tidal transition zone facies in the McMurray Formation (Christina River, Alberta, Canada), with emphasis on the reflection of flow intensity in bottomset architecture

    NARCIS (Netherlands)

    Martinius, A. W.; Jablonski, B. V J; Fustic, M.; Strobl, R.; Van den Berg, J. H.

    2015-01-01

    An outcrop of the McMurray Formation along the Christina River (Alberta, Canada) has been investigated to better understand depositional processes and setting. The succession is formed by large-scale tabular sets of unidirectional trough cross-stratification. Many of these sets are characterized by

  8. The McMillan-Mayer framework and the theory of electrolyte solutions

    DEFF Research Database (Denmark)

    Breil, Martin Peter; Mollerup, Jørgen

    2006-01-01

    In electrolyte thermodynamics one often speaks of two thermodynamic frameworks; the Lewis-Randall framework (characterised by temperature, pressure. and mole numbers) and the McMillan-Mayer framework (characterised by temperature, total volume, solute mole numbers, and solvent chemical potential......). However, there is only one framework in thermodynamics; the apparent difference between the two 'frameworks' is, in electrolyte thermodynamics, due to the change in the pressure caused by the charging process at constant volume and solvent chemical potential. The so-called McMillan-Mayer framework is set...... in the context of the classical thermodynamics and the use of it is examplified by the Debye-Huckel theory. The so-called McMillan-Mayer framework is superfluous when the thermodynamics of the electrolyte solutions is described by the Helmholtz energy functions. (c) 2006 Elsevier B.V. All rights reserved....

  9. Optimal strategic reasoning with McNaughton functions

    Czech Academy of Sciences Publication Activity Database

    Kroupa, Tomáš; Majer, Ondrej

    2014-01-01

    Roč. 55, č. 6 (2014), s. 1458-1468 ISSN 0888-613X R&D Projects: GA ČR GAP402/12/1309 Institutional support: RVO:67985556 ; RVO:67985807 Keywords : Lukasiewicz logic * McNaughton function * Infinite game Subject RIV: BA - General Mathematics Impact factor: 2.451, year: 2014

  10. The McGruer Lorne Class Yachts - Their History and Architecture

    OpenAIRE

    Cawthorne, Douglas

    2013-01-01

    Established in 1911 on the river Clyde, the family-run firm of McGruer & Company Ltd created some of the finest sailing yachts ever built in Scotland. The smallest of these were the Lorne Class, designed in the 1960's by the legendary James McGruer as "affordable" family sail cruisers. At 28 ft. LOA not only did they have the thoroughbred lines and renowned sea-keeping qualities of their larger cousins but they were one of the last and best examples in small cruising yacht design of the centu...

  11. Ocean current observations near McMurdo Station, Antarctica from 1991 to 1993: Relation to wastewater discharge dispersal

    International Nuclear Information System (INIS)

    Barry, J.P.

    1994-08-01

    Analyses of ocean currents in the vicinity of McMurdo Station, Antarctica, are relevant to the transport and dispersal of wastewater from the McMurdo Station sewage outfall pipe. Observations of ocean currents during the initial phases of this study have been presented by Howington and McFeters. These studies, using coliform bacterial counts as an indicator of dispersion of the wastewater plume and current meters to measure flow patterns, indicated that dispersal of the plume by local currents does not effectively remove the plume from the vicinity of McMurdo Sound, under the present outfall pipe location. Moreover, these studies suggest that, although the flow pattern is generally consistent with transport of the plume away from McMurdo Station, episodes of current reversal are sufficient to transport the wastewater plume along the shore toward the southeast, eventually overlapping the seawater intake area near the McMurdo jetty. Several concerns included (a) impacts of wastewater inputs to nearshore benthic and pelagic habitats adjacent to McMurdo Station, (b) effects of wastewater input to the McMurdo Station fresh water intake source, and (c) reduction in human impacts on the McMurdo Sound ecosystem. These concerns motivated studies to characterize nearshore currents more extensively in relation to dispersal of the wastewater plume. This report discusses analysis results of current observations from November 1992 to November 1993

  12. Functional Characterization of MC1R-TUBB3 Intergenic Splice Variants of the Human Melanocortin 1 Receptor.

    Directory of Open Access Journals (Sweden)

    Cecilia Herraiz

    Full Text Available The melanocortin 1 receptor gene (MC1R expressed in melanocytes is a major determinant of skin pigmentation. It encodes a Gs protein-coupled receptor activated by α-melanocyte stimulating hormone (αMSH. Human MC1R has an inefficient poly(A site allowing intergenic splicing with its downstream neighbour Tubulin-β-III (TUBB3. Intergenic splicing produces two MC1R isoforms, designated Iso1 and Iso2, bearing the complete seven transmembrane helices from MC1R fused to TUBB3-derived C-terminal extensions, in-frame for Iso1 and out-of-frame for Iso2. It has been reported that exposure to ultraviolet radiation (UVR might promote an isoform switch from canonical MC1R (MC1R-001 to the MC1R-TUBB3 chimeras, which might lead to novel phenotypes required for tanning. We expressed the Flag epitope-tagged intergenic isoforms in heterologous HEK293T cells and human melanoma cells, for functional characterization. Iso1 was expressed with the expected size. Iso2 yielded a doublet of Mr significantly lower than predicted, and impaired intracellular stability. Although Iso1- and Iso2 bound radiolabelled agonist with the same affinity as MC1R-001, their plasma membrane expression was strongly reduced. Decreased surface expression mostly resulted from aberrant forward trafficking, rather than high rates of endocytosis. Functional coupling of both isoforms to cAMP was lower than wild-type, but ERK activation upon binding of αMSH was unimpaired, suggesting imbalanced signaling from the splice variants. Heterodimerization of differentially labelled MC1R-001 with the splicing isoforms analyzed by co-immunoprecipitation was efficient and caused decreased surface expression of binding sites. Thus, UVR-induced MC1R isoforms might contribute to fine-tune the tanning response by modulating MC1R-001 availability and functional parameters.

  13. Market Entry Strategies : Case: McDonald's entry on the Russian market

    OpenAIRE

    Karataev, Oleg

    2015-01-01

    The thesis considers the entry strategy and development of the company McDonald's into international markets. The theoretical aspects of the entry strategy of the company into the international markets. Analyzes the key features of the development of McDonald's in Russia. Investigated the prospects of the company in international markets. In theoretic part there was regarded some important aspects of international strategic management, such as: strategic alternatives, elements and levels o...

  14. Respiratory Medicine at McMaster University, Hamilton, Ontario: 1968 to 2013

    Directory of Open Access Journals (Sweden)

    Norman L Jones

    2014-01-01

    Full Text Available The medical school at McMaster University (Hamilton, Ontario was conceived in 1965, and admitted the first class in 1969. John Evans became the founding Dean and he invited EJ Moran Campbell to be the first Chairman of the Department of Medicine. Moran Campbell, already a world figure in respiratory medicine and physiology, arrived at McMaster in September 1968, and he invited Norman Jones to be Coordinator of the Respiratory Programme.

  15. Respiratory Medicine at McMaster University, Hamilton, Ontario: 1968 To 2013

    Directory of Open Access Journals (Sweden)

    Norman L Jones

    2014-01-01

    Full Text Available The medical school at McMaster University (Hamilton, Ontario was conceived in 1965 and admitted the first class in 1969. John Evans became the founding Dean and he invited Moran Campbell to be the first Chairman of the Department of Medicine. Moran Campbell, already a world figure in respiratory medicine and physiology, arrived at McMaster in September 1968, and he invited Norman Jones to be Coordinator of the Respiratory Programme.

  16. Uus menüü kasvatas McDonald'si käivet / Annika Matson

    Index Scriptorium Estoniae

    Matson, Annika, 1976-

    2003-01-01

    USA kiirtoiduketi McDonald's vähemalt aasta tegutsenud söögikohtade käive kasvas enam kui 6% eelkõige tänu uuele menüüle ja edukale reklaamikampaaniale. Diagrammid: McDonald'si käive ja kasum kasvasid 13%

  17. Improving MC and A Oversight in Russia by Implementing Measurement and Training Programs

    International Nuclear Information System (INIS)

    Bokov, Dmitry; Byers, Kenneth R.

    2004-01-01

    As the Russian State regulatory agency responsible for oversight of nuclear material control and accounting (MC and A), Gosatomnadzor of Russia (GAN) determines the status of the MC and A programs at Russian facilities. Last year, GAN developed and implemented their Nuclear Material Measurement Program Plan which documents current non-destructive assay (NDA) measurement capability in all regions of GAN; provides justification for upgrades to equipment, procedures and training; and defines the inspector-facility operator interface as it relates to NDA measurement equipment use. This Program Plan has helped to give the GAN inspection measurements more legal and official status as an oversight tool, and has also helped to improve other GAN MC and A oversight activities. These improvements include developing a tamper-indicating device program, conducting NDA workshops at specific Russian nuclear facilities to better train MC and A inspectors, and developing training evaluation programs. The Program is an important tool to address the GAN role in oversight of the Russian Federal Information System nuclear material database. This paper describes the feedback received from the GAN regional offices on the implementation of the Program Plan during its first year in operation and how the Program Plan has affected other GAN inspection activities to improve MC and A oversight.

  18. Mysteries of Mind and Matter in the Perspective of Colin McGinn’s Philosophy

    Directory of Open Access Journals (Sweden)

    Dmytro Sepetyi

    2016-02-01

    Full Text Available The paper discusses the approach to the mind-body problem that was developed by Colin McGinn and is known as “mysterianism”. The basic thesis of this approach, which McGinn opposes to both materialism and dualism, is that consciousness and its relationship to physical reality is an inscrutable mystery that cannot be get over in principle, because of insurmountable, constitutive limitations of human mind. In this paper, the critical analysis of McGinn’s approach is given. It is pointed out that McGinn’s thesis of the inscrutablility of the mind-body relationship is based on the ungrounded idea that a mediating substance is necessary. An argument is made that the mind-body relationship is better understood as interaction that is mediated only by natural psychophysical laws. McGinn’s hypothesis of the origin of physical space in a non-spatial reality that has the same nature as consciousness is explained in the context of different interpretations of the Big Bang theo- ry. It is argued that McGinn’s hypothesis does not provide a solution to the problem of the origin of human consciousness, because consciousness belongs to mental individuals whose emergence is just as unexplainable by the hypothesis of non-spatial reality as it is by physical processes.

  19. GPM GROUND VALIDATION NOAA S-BAND PROFILER MINUTE DATA MC3E V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The GPM Ground Validation NOAA S-Band Profiler Minute Data MC3E dataset was gathered during the Midlatitude Continental Convective Clouds Experiment (MC3E) in...

  20. McCarthy variations in a modal key

    NARCIS (Netherlands)

    van Benthem, J.

    2011-01-01

    We take a fresh look at some major strands in John McCarthy's work from a logician's perspective. First, we re-analyze circumscription in dynamic logics of belief change under hard and soft information. Next, we re-analyze the regression method in the Situation Calculus in terms of update axioms for

  1. DWH MC 252: Subsurface Oil Transport

    Science.gov (United States)

    Beegle-Krause, C. J.; Boyer, T.; Murray, D.

    2010-12-01

    Before reaching the ocean surface, the oil and gas released from the DWH MC 252 blowout at 1500 m moves as a buoyant plume until the trapping depth and plume transition point are reached (Zheng et al 2002). At the transition point, the oil droplets and bubbles move independently of each other, and rise at a rate related to their diameter. The oil density, droplet size distribution and currents primarily determine the distribution of the oil between: Large droplets that rise quickly and create a surface expression of the oil. Moderate size droplets that rise over the course of days, and so spread out quite differently than the surface oil, and commonly do not reach the surface in large enough quantities to create a surface sheen. These droplets separate in the currents, particularly in the strong current shear in upper 500 m currents. Very tiny droplets that rise very slowly, over the course or weeks to months, and may be removed by dissolution, biodegradation or marine snow before ever reaching the surface. Modeling and observations (Joint Analysis Group, 2010) confirm the presence of a deep layer of oil and gas between approximately 1100 and 1300 m over the release location and spreading out along the isopycnal surfaces. Later in the event, a small oxygen depression was a proxy for where oil and gas had been. The DWH MC252 well is located at intermediate depth in the Gulf of Mexico (GoM). The water mass is Antarctic Intermediate Water, which enters and exits the GoM through the Yucatan Straits. Surface influences, such as Loop Current Frontal Eddies (e.g. Berger et al 2000) can reach down to these depths, and alter the flow within De Soto Canyon. The water mass containing the deep layer of oil droplets changes depth within the GoM, but does not reach above a depth of about 900 m. There are no physical processes that could cause this deep layer of oil to reach the continental shelf or the Florida Straits. Observed and historical hydrographic data, observations

  2. McDowell’s New Conceptualism and the Difference between Chickens, Colours and Cardinals

    DEFF Research Database (Denmark)

    Gersel, Johan Peter; Thybo Jensen, Rasmus; Thaning, Morten Sørensen

    2017-01-01

    McDowell recently renounced the assumption that the content of any knowledgeable, perceptual judgement must be included in the content of the knowledge grounding experience. We argue that McDowell’s introduction of a new category of non-inferential, perceptual knowledge is incompatible with the m...

  3. Properties and reactivity of Fe-organic matter associations formed by coprecipitation versus adsorption: Clues from arsenate batch adsorption

    Science.gov (United States)

    Mikutta, Robert; Lorenz, Dennis; Guggenberger, Georg; Haumaier, Ludwig; Freund, Anja

    2014-11-01

    Ferric oxyhydroxides play an important role in controlling the bioavailability of oxyanions such as arsenate and phosphate in soil. Despite this, little is known about the properties and reactivity of Fe(III)-organic matter phases derived from adsorption (reaction of organic matter (OM) to post-synthesis Fe oxide) versus coprecipitation (formation of Fe oxides in presence of OM). Coprecipitates and adsorption complexes were synthesized at pH 4 using two natural organic matter (NOM) types extracted from forest floor layers (Oi and Oa horizon) of a Haplic Podzol. Iron(III) coprecipitates were formed at initial molar metal-to-carbon (M/C) ratios of 1.0 and 0.1 and an aluminum (Al)-to-Fe(III) ratio of 0.2. Sample properties were studied by X-ray diffraction, X-ray photoelectron spectroscopy (XPS), N2 gas adsorption, dynamic light scattering, and electrophoretic mobility measurements. Arsenic [As(V)] adsorption to Fe-OM phases was studied in batch experiments (168 h, pH 4, 100 μM As). The organic carbon (OC) contents of the coprecipitates (82-339 mg g-1) were higher than those of adsorption complexes (31 and 36 mg g-1), leading to pronounced variations in specific surface area (9-300 m2 g-1), average pore radii (1-9 nm), and total pore volumes (11-374 mm3 g-1) but being independent of the NOM type or the presence of Al. The occlusion of Fe solids by OM (XPS surface concentrations: 60-82 atom% C) caused comparable pHPZC (1.5-2) of adsorption complexes and coprecipitates. The synthesis conditions resulted in different Fe-OM association modes: Fe oxide particles in 'M/C 0.1' coprecipitates covered to a larger extent the outermost aggregate surfaces, for some 'M/C 1.0' coprecipitates OM effectively enveloped the Fe oxides, while OM in the adsorption complexes primarily covered the outer aggregate surfaces. Despite of their larger OC contents, adsorption of As(V) was fastest to coprecipitates formed at low Fe availability (M/C 0.1) and facilitated by desorption of weakly

  4. McGill's Integrated Civil and Common Law Program.

    Science.gov (United States)

    Morissette, Yves-Marie

    2002-01-01

    Describes the bijural program of McGill University Faculty of Law. The program educates all first-degree law students in both the common law and civil law traditions, preparing them for the increasing globalization of legal practice. (EV)

  5. McClintock's challenge in the 21st century

    KAUST Repository

    Fedoroff, Nina V.

    2012-01-01

    In 1950, Barbara McClintock published a Classic PNAS article, "The origin and behavior of mutable loci in maize," which summarized the evidence leading to her discovery of transposition. The article described a number of genome alterations revealed

  6. Photochromic properties of modified nanodiamonds

    Science.gov (United States)

    Venidiktova, O. V.; Valova, T. M.; Barachevsky, V. A.; Ait, A. O.; Lebedev-Stepanov, P. V.; Vul, A. Ya.; Koltsova, L. S.; Shienok, A. I.; Zaichenko, N. L.

    2017-05-01

    A functionalization of the surface of detonation nanodiamonds by photochromic spirocompounds from the classes of spiropyrans and spirooxazines has been carried out for the first time. A comparative study of the interaction of nanodiamonds with positive and negative potential is performed by the spectral-kinetic method, which shows the possibility of surface modification by only functionalized molecules of spirocompounds with the formation of surface proton complexes. This is confirmed by the hypsochromic shift of the absorption bands of the photoinduced merocyanine forms of adsorbed molecules of spirocompounds and by the decrease of the speed of their dark relaxation to the initial state in the presence of nanodiamonds with a negative potential.

  7. Waste minimization: A team approach at McGuire nuclear

    International Nuclear Information System (INIS)

    Poteat, E.L.

    1995-01-01

    The production of radioactive waste and its subsequent disposal is a costly proposition. Burial of low-level waste (LLW), if available at all, is expensive and getting more so. The availability of disposal options is often subject to the whims and vagaries of political forces that cannot be predicted, let alone controlled in any way by the members of the nuclear community. On-site storage is a limited and, quite often, an extremely difficult process to put into place. After LLW has been generated, various volume reduction techniques are available, but these can vary widely in cost and effectiveness. If and when new disposal sites are available, the waste acceptance criteria may be such that some or all of the volume reduction processes will not produce an acceptable final waste form. Consequently, the best thing to do is probably deceptively simple: Do not generate the waste in the first place. This is the philosophy that McGuire nuclear station operates under, and this paper discusses the team approach that has been developed to support this idea

  8. Criteria for Determination of MC and A System Effectiveness

    International Nuclear Information System (INIS)

    Johnson, Geneva; Long, DeAnn; Albright, Ross; Wright, John

    2008-01-01

    The Nevada Test Site (NTS) is a test bed for implementation of the Safeguards First Principles Initiative (SFPI), a risk-based approach to Material Control and Accountability (MC and A) requirements. The Comprehensive Assessment of Safeguards Strategies (COMPASS) model is used to determine the effectiveness of safeguards systems under SFPI. Under this model, MC and A is divided into nine primary elements. Each element is divided into sub-elements. Then, each sub-element is assigned two values, effectiveness and contribution, that are used to calculate the rating. Effectiveness is a measure of sub-element implementation and how well it meets requirements. Contribution is a relative measure of the importance, and functions as a weighting factor. The COMPASS model provides the methodology for calculation of element and subelement, but not the actual criteria. Each site must develop its own criteria. For the rating to be meaningful, the effectiveness criteria must be objective and based on explicit, measurable criteria. Contribution (weights) must reflect the importance within the MC and A program. This paper details the NTS approach to system effectiveness and contribution values, and will cover the following: the basis for the ratings, an explanation of the contribution weights, and the objective, performance-based effectiveness criteria. Finally, the evaluation process will be described

  9. Is the standard dose rate for de-contamination, 0.23 mc-Sv/hr, truly 1 mSv/year?

    International Nuclear Information System (INIS)

    Furuta, Sadaaki

    2014-01-01

    Examined is the validity of the standard dose rates in the title, which have been additionally defined by Ministry of the Environment (ME) to the measures of Fukushima Nuclear Power Plant Accident. The standard 0.23 mc-Sv/hr is the sum of natural ambient dose rate 0.04 mc-Sv/hr in average of Japan as measured with NaI scintillation surveymeter, plus additional accidental exposure dose 1 mSv/y, which is defined equivalent to 0.19 mc-Sv/hr. Here, the equation of addition 0.04+0.19 mc-Sv/hr is not exactly correct because the unit of each dose value has different means as follows. The natural dose is derived from the value 5.8 mc-R/hr (0.038 mc-Sv/hr, effective dose) of the average national natural dose data (2011) of Ministry of Education, Culture, Sports, Science and Technology. However, if the measurement is done with the surveymeter which practically gives 1 cm dose equivalent, the rate is calculated to be 0.06 mc-Sv/hr. When the Fukushima prefectural natural dose rate 6.4 mc-R/hr is employed, the calculation gives 0.07 mc-Sv/hr. ME defines the additional doses to be 0.19 mc-Sv/hr and 1 mSv/y, which are derived from the calculation: (0.19 mc-Sv/hr x 8 hr outdoor + 0.19 mc-Sv/hr x 0.4 indoor, shielded) x 365 d/y= 1 mSv/y. The dose is assumed to be measurable with the surveymeter (1 cm dose equivalent) and thereby calculation, if the source is mainly "1"3"4Cs and "1"3"7Cs, gives the effective dose of 0.32 mc-Sv/hr to be managed by the meter. As this, the effective dose unit and 1 cm equivalent dose unit are used for calculation of the administrative standard dose rate of 1 mSv/y, which should be recognized by both radiological experts and administration for the explanation to general public. (T.T.)

  10. spMC: an R-package for 3D lithological reconstructions based on spatial Markov chains

    Science.gov (United States)

    Sartore, Luca; Fabbri, Paolo; Gaetan, Carlo

    2016-09-01

    The paper presents the spatial Markov Chains (spMC) R-package and a case study of subsoil simulation/prediction located in a plain site of Northeastern Italy. spMC is a quite complete collection of advanced methods for data inspection, besides spMC implements Markov Chain models to estimate experimental transition probabilities of categorical lithological data. Furthermore, simulation methods based on most known prediction methods (as indicator Kriging and CoKriging) were implemented in spMC package. Moreover, other more advanced methods are available for simulations, e.g. path methods and Bayesian procedures, that exploit the maximum entropy. Since the spMC package was developed for intensive geostatistical computations, part of the code is implemented for parallel computations via the OpenMP constructs. A final analysis of this computational efficiency compares the simulation/prediction algorithms by using different numbers of CPU cores, and considering the example data set of the case study included in the package.

  11. Malrotation of the McGhan Style 510 prosthesis.

    NARCIS (Netherlands)

    Schots, J.M.; Fechner, M.R.; Hoogbergen, M.M.; Tits, H.W.H.J.

    2010-01-01

    BACKGROUND: Anatomically shaped cohesive silicone breast implants are frequently used in aesthetic and reconstructive surgery. After successful results with the Style 410 prosthesis, McGhan (Natrelle, Allergan) introduced the Style 510 prosthesis. After using this novel prosthesis, the authors

  12. Outcome of Boyd-McLeod procedure for recalcitrant lateral epicondylitis of elbow.

    Science.gov (United States)

    Reddy, V R M; Satheesan, K S; Bayliss, N

    2011-08-01

    Various surgical procedures including percutaneous and open release and arthroscopic procedures have been described to treat recalcitrant tennis elbow. We present the outcome of Boyd-McLeod surgical procedure for tennis elbow resistant to non-operative treatment in twenty-seven patients (twenty-nine limbs). Boyd McLeod procedure involves excision of the proximal portion of the annular ligament, release of the origin of the extensor muscles, excision of the bursa if present, and excision of the synovial fringe. The average time interval from the onset of symptoms of tennis elbow until surgery was 28 months (range 8-72 months). Of those patients, 91% reported complete relief of symptoms with return to full normal activities including sports. Average post-operative time for return to professional/recreational activity was 5 weeks. One case developed pain secondary to ectopic bone formation after surgery, which settled after excision, and in another there was no pain relief with Boyd McLeod procedure. Two patients had scar tenderness that did not affect the final outcome. We conclude that Boyd-McLeod procedure is an effective treatment option in patients with resistant lateral epicondylitis.

  13. McREL Leadership Responsibilities through the Lens of Data: The Critical Nine

    Directory of Open Access Journals (Sweden)

    Cheryl James-Ward

    2015-09-01

    Full Text Available In the United States, the beginning of the 21st century also ushered in a new era of school accountability and reform with the No Child Left Behind Act [NCLB] (US Department of Education, 2010. Although the law is no longer in effect, the district and school level accountability that it brought remains. The accountability and need for ongoing improvement rest squarely on the shoulders of school principals, many of whom have no skill sets or experience with the use of data to improve student outcomes. This article utilizes the research studies and findings from the Mid-Continent Research for Education and Learning (McREL lab, in order to examine those leadership responsibilities intertwined with the use of data to improve student achievement. McREL has identified 21 leadership responsibilities that describe the knowledge and skills school leaders need to positively impact student achievement. This analysis focuses on the McREL leadership responsibilities with an effect size of .25 or higher that require a focus on data. The use of hard and soft data to focus improvement is then analyzed and expanded upon through the McREL lens.

  14. Shawarmas contre McDo.

    Directory of Open Access Journals (Sweden)

    Charles-Édouard de Suremain

    2008-05-01

    Full Text Available La question des identités locales et de leur articulation à la mondialisation et à la standardisation est abordée ici à partir de l’alimentation. Après avoir présenté les lieux où il est possible de manger hors de chez soi à La Paz, je m’attarderai sur les particularités du McDonald’s bolivien. Ces données permettront de suivre la genèse d’un anti-modèle alimentaire, le shawarma, qui a connu son apogée durant la « troisième guerre mondiale », la période démarrant dans la foulée des attentats du 11 septembre 2001. L’hypothèse est que les contestations identitaires dans la sphère alimentaire peuvent s’appuyer sur les logiques de la mondialisation alimentaire et s’ériger contre elle, tout en évitant les écueils de la standardisation alimentaire.Shawarmas versus Macdonald’s. Identities contesting food globalization and standardization (Bolivia Local identities and their tendency toward globalization and standardization is analyzed here with food as an example. After briefly reviewing the different places where one can eat out in La Paz, the particularities of the Bolivian McDonald’s are outlined. These data allow us to witness the birth of a food anti-model, the shawarma, which reached its pinnacle during the so-called ‘Third World War’, the period following September 11, 2001. The hypothesis is that identity contestations in the food sphere can be based on the logic of food globalization -and at the same time be constructed against them- avoiding food standardization pitfalls.

  15. Development of melanoma-targeted polymer micelles by conjugation of a melanocortin 1 receptor (MC1R) specific ligand.

    Science.gov (United States)

    Barkey, Natalie M; Tafreshi, Narges K; Josan, Jatinder S; De Silva, Channa R; Sill, Kevin N; Hruby, Victor J; Gillies, Robert J; Morse, David L; Vagner, Josef

    2011-12-08

    The incidence of malignant melanoma is rising faster than that of any other cancer in the United States. Because of its high expression on the surface of melanomas, MC1R has been investigated as a target for selective imaging and therapeutic agents against melanoma. Eight ligands were screened against cell lines engineered to overexpress MC1R, MC4R, or MC5R. Of these, compound 1 (4-phenylbutyryl-His-dPhe-Arg-Trp-NH(2)) exhibited high (0.2 nM) binding affinity for MC1R and low (high nanomolar) affinities for MC4R and MC5R. Functionalization of the ligand at the C-terminus with an alkyne for use in Cu-catalyzed click chemistry was shown not to affect the binding affinity. Finally, formation of the targeted polymer, as well as the targeted micelle formulation, also resulted in constructs with low nanomolar binding affinity.

  16. Generalized eMC implementation for Monte Carlo dose calculation of electron beams from different machine types.

    Science.gov (United States)

    Fix, Michael K; Cygler, Joanna; Frei, Daniel; Volken, Werner; Neuenschwander, Hans; Born, Ernst J; Manser, Peter

    2013-05-07

    The electron Monte Carlo (eMC) dose calculation algorithm available in the Eclipse treatment planning system (Varian Medical Systems) is based on the macro MC method and uses a beam model applicable to Varian linear accelerators. This leads to limitations in accuracy if eMC is applied to non-Varian machines. In this work eMC is generalized to also allow accurate dose calculations for electron beams from Elekta and Siemens accelerators. First, changes made in the previous study to use eMC for low electron beam energies of Varian accelerators are applied. Then, a generalized beam model is developed using a main electron source and a main photon source representing electrons and photons from the scattering foil, respectively, an edge source of electrons, a transmission source of photons and a line source of electrons and photons representing the particles from the scrapers or inserts and head scatter radiation. Regarding the macro MC dose calculation algorithm, the transport code of the secondary particles is improved. The macro MC dose calculations are validated with corresponding dose calculations using EGSnrc in homogeneous and inhomogeneous phantoms. The validation of the generalized eMC is carried out by comparing calculated and measured dose distributions in water for Varian, Elekta and Siemens machines for a variety of beam energies, applicator sizes and SSDs. The comparisons are performed in units of cGy per MU. Overall, a general agreement between calculated and measured dose distributions for all machine types and all combinations of parameters investigated is found to be within 2% or 2 mm. The results of the dose comparisons suggest that the generalized eMC is now suitable to calculate dose distributions for Varian, Elekta and Siemens linear accelerators with sufficient accuracy in the range of the investigated combinations of beam energies, applicator sizes and SSDs.

  17. Challenges with modifications of the McClean Lake mill to process midwest ore

    International Nuclear Information System (INIS)

    Nguyen, T.T.; Backham, L.

    2010-01-01

    Midwest is a unique uranium deposit with exceptionally high arsenic content. The ore body is located 17 km west of the McClean Lake operation. The McClean Lake mill will be modified to process Midwest ore and handle solid wastes from the Midwest water treatment plant. This paper describes the modifications required of the McClean Lake mill, process challenges associated with treatment of the arsenic, and the possibility of recovering nickel and cobalt as a by-product. It also reviews the complexity in the design of the Midwest water treatment facility which incorporates reverse osmosis technology with conventional physical-chemical water treatment. (author)

  18. Design features and operating characteristics of the MC-50 cyclotron

    International Nuclear Information System (INIS)

    Bak, Hae Ill; Bak, Joo Shik

    1989-01-01

    The MC-50 cyclotron at Korean Cancer Center Hospital is now operational for neutron therapy and medical radioisotope production. Design features, mechanical structures and operating characteristics of the MC-50 are described in this paper. Optimum operating condition for this cyclotron has been determined by the repetitive running, and the performances of the internal beam have been investigated through the measurements of intensity and spatial distribution of the internal beam as a function of the radius of the cyclotron. Routinely, the 40 μA of 50 MeV protons have been obtained at first Faraday cup with a extraction efficiency of 61%. (Author)

  19. Plan estratégico para Mc Donald's China 2016-2020

    OpenAIRE

    Vila Castillo, Carla Abigaíl; Ysla Regalado, Jennifer; Bustamante Huamán, Daniel Guillermo

    2016-01-01

    Mc Donald’s es una corporación estadounidense líder del mercado de comida rápida, con más de 76 años en el mercado y presencia en más de 100 países con alrededor de 36.525 locales entre propios y franquiciados. El éxito de Mc Donald’s radica en ofrecer una variedad de productos tales como hamburguesas, postres y café, destacando la famosa Big Mac, productos a un precio accesible para todos los mercados donde opera. Esto como consecuencia de su estrategia genérica de Liderazgo de costo tipo...

  20. Three Dimensional Spherical Display Systems and McIDAS: Tools for Science, Education and Outreach

    Science.gov (United States)

    Kohrs, R.; Mooney, M. E.

    2010-12-01

    The Space Science and Engineering Center (SSEC) and Cooperative Institute for Meteorological Satellite Studies (CIMSS) at the University of Wisconsin are now using a 3D spherical display system and their Man computer Data Access System (McIDAS)-X and McIDAS-V as outreach tools to demonstrate how scientists and forecasters utilize satellite imagery to monitor weather and climate. Our outreach program displays orbits and data coverage of geostationary and polar satellites and demonstrates how each is beneficial for the remote sensing of Earth. Global composites of visible, infrared and water vapor images illustrate how satellite instruments collect data from different bands of the electromagnetic spectrum to monitor global weather patterns 24 hours a day. Captivating animations on spherical display systems are proving to be much more intuitive than traditional 2D displays, enabling audiences to view satellites orbiting above real-time weather systems circulating the entire globe. Complimenting the 3D spherical display system are the UNIX-based McIDAS-X and Java-based McIDAS-V software packages. McIDAS is used to composite the real-time global satellite data and create other weather related derived products. Client and server techniques used by these software packages provide the opportunity to continually update the real-time content on our globe. The enhanced functionality of McIDAS-V extends our outreach program by allowing in-depth interactive 4-dimensional views of the imagery previously viewed on the 3D spherical display system. An important goal of our outreach program is the promotion of remote sensing research and technology at SSEC and CIMSS. The 3D spherical display system has quickly become a popular tool to convey societal benefits of these endeavors. Audiences of all ages instinctively relate to recent weather events which keeps them engaged in spherical display presentations. McIDAS facilitates further exploration of the science behind the weather

  1. Interview with Harold McGee

    OpenAIRE

    Mac Con Iomaire, Máirtín

    2016-01-01

    Harold McGee was born on the East coast of America but grew up in Chicago. He writes about the chemistry of food and cooking. He took up this odd vocation after studies at the California Institute of Technology and at Yale University, where he wrote a doctoral thesis with the prophetic title "Keats and the Progress of Taste." After several years as a literature and writing instructor at Yale, he decided to practice what he'd been teaching, and write a book about the science of everyday life. ...

  2. Precise measurement of chromium isotopes by MC-ICPMS

    DEFF Research Database (Denmark)

    Schiller, Martin; Van Kooten, Elishevah; Holst, Jesper Christian

    2014-01-01

    We report novel analytical procedures allowing for the concurrent determination of the stable and mass-independent Cr isotopic composition of silicate materials by multiple collector inductively coupled mass spectrometry (MC-ICPMS). In particular, we focus on improved precision of the measurement...

  3. What would McLuhan say about the smartphone?: applying McLuhan’s tetrad to the smartphone

    OpenAIRE

    Adam, Isabelle

    2016-01-01

    In this essay, the smartphone as a new technology and medium is analysed with regards to its effects on individuals and society. McLuhan’s tetrad serves as a framework for analysis, consisting of a set of four effects to examine media in their historical context and present environment as well as the characteris-tics and attributes of the medium itself. These effects include: enhancement, obsolescence, retrieval, and reversal. The smartphone enhances the accessibility and convenience of the m...

  4. Magnetically actuated mechanical stimuli on Fe3O4/mineralized collagen coatings to enhance osteogenic differentiation of the MC3T3-E1 cells.

    Science.gov (United States)

    Zhuang, Junjun; Lin, Suya; Dong, Lingqing; Cheng, Kui; Weng, Wenjian

    2018-04-15

    Mechanical stimuli at the bone-implant interface are considered to activate the mechanotransduction pathway of the cell to improve the initial osseointegration establishment and to guarantee clinical success of the implant. However, control of the mechanical stimuli at the bone-implant interface still remains a challenge. In this study, we have designed a strategy of a magnetically responsive coating on which the mechanical stimuli is controlled because of coating deformation under static magnetic field (SMF). The iron oxide nanoparticle/mineralized collagen (IOP-MC) coatings were electrochemically codeposited on titanium substrates in different quantities of IOPs and distributions; the resulting coatings were verified to possess swelling behavior with flexibility same as that of hydrogel. The relative quantity of IOP to collagen and the IOP distribution in the coatings were demonstrated to play a critical role in mediating cell behavior. The cells present on the outer layer of the distributed IOP-MC (O-IOP-MC) coating with a mass ratio of 0.67 revealed the most distinct osteogenic differentiation activity being promoted, which could be attributed to the maximized mechanical stimuli with exposure to SMF. Furthermore, the enhanced osteogenic differentiation of the stimulated MC3T3-E1 cells originated from magnetically actuated mechanotransduction signaling pathway, embodying the upregulated expression of osteogenic-related and mechanotransduction-related genes. This work therefore provides a promising strategy for implementing mechanical stimuli to activate mechanotransduction on the bone-implant interface and thus to promote osseointegration. The magnetically actuated coating is designed to produce mechanical stimuli to cells for promoting osteogenic differentiation based on the coating deformation. Iron oxide nanoparticles (IOPs) were incorporated into the mineralized collagen coatings (MC) forming the composite coatings (IOP-MC) with spatially distributed IOPs

  5. Charles J. McMahon Interfacial Segregation and Embrittlement Symposium

    National Research Council Canada - National Science Library

    Vitek, Vaclav

    2003-01-01

    .... McMahon Interfacial Segregation and Embrittlement Symposium: Grain Boundary Segregation and Fracture in Steels was sponsored by ASM International, Materials Science Critical Technology Sector, Structural Materials Division, Materials Processing...

  6. Strengths and Weaknesses of McNamara's Evolutionary Psychological Model of Dreaming

    Directory of Open Access Journals (Sweden)

    Sandra Olliges

    2010-10-01

    Full Text Available This article includes a brief overview of McNamara's (2004 evolutionary model of dreaming. The strengths and weaknesses of this model are then evaluated in terms of its consonance with measurable neurological and biological properties of dreaming, its fit within the tenets of evolutionary theories of dreams, and its alignment with evolutionary concepts of cooperation and spirituality. McNamara's model focuses primarily on dreaming that occurs during rapid eye movement (REM sleep; therefore this article also focuses on REM dreaming.

  7. The influence of room temperature on Mg isotope measurements by MC-ICP-MS.

    Science.gov (United States)

    Zhang, Xing-Chao; Zhang, An-Yu; Zhang, Zhao-Feng; Huang, Fang; Yu, Hui-Min

    2018-03-24

    We observed that the accuracy and precision of magnesium (Mg) isotope analyses could be affected if the room temperature oscillated during measurements. To achieve high quality Mg isotopic data, it is critical to evaluate how the unstable room temperature affects Mg isotope measurements by multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS). We measured the Mg isotopes for the reference material DSM-3 using MC-ICP-MS under oscillating room temperatures in spring. For a comparison, we also measured the Mg isotopes under stable room temperatures, which was achieved by the installation of an improved temperature control system in the laboratory. The δ 26 Mg values measured under oscillating room temperatures have a larger deviation (δ 26 Mg from -0.09 to 0.08‰, with average δ 26 Mg = 0.00 ± 0.08 ‰) than those measured under a stable room temperature (δ 26 Mg from -0.03 to 0.03‰, with average δ 26 Mg = 0.00 ± 0.02 ‰) using the same MC-ICP-MS system. The room temperature variation can influence the stability of MC-ICP-MS. Therefore, it is critical to keep the room temperature stable to acquire high precise and accurate isotopic data when using MC-ICP-MS, especially when using the sample-standard bracketing (SSB) correction method. This article is protected by copyright. All rights reserved.

  8. Recent developments in the ROCS/MC code for retrieving local power information in coarse-mesh reactor analysis

    International Nuclear Information System (INIS)

    Grill, S.F.; Jonsson, A.; Crump, M.W.

    1983-01-01

    The inclusion of 3-D effects in PWR analysis is necessary for accurate predictions of reactivity, power distributions, and reactivity coefficients. The ROCS/MC code system has been developed by Combustion Engineering to provide 3-D coarse mesh analysis (ROCS) with the capability to retrieve local information on flux, power and burnup (MC). A review of the finite difference representation of the MC diffusion equation, along with recent improvements to the ROCS/MC system are presented. These improvements include the implementation if fine mesh radial boundary conditions and internal calculation of coarse mesh boundary conditions, generalization of the imbedded calculation to account for the local neighboring environment, and the automation of ROCS/MC links to C-E's code system for in-core power distribution monitoring and core-follow analysis. The results of the ROCS/MC verification program are described and show good agreement with C-E's ROCS/PDQ based methodologies

  9. Integrating evidence into practice: use of McKenzie-based treatment for mechanical low back pain

    Directory of Open Access Journals (Sweden)

    Clarke S

    2011-11-01

    Full Text Available Angela Dunsford1, Saravana Kumar1,2, Sarah Clarke1 1International Centre for Allied Health Evidence, 2School of Health Sciences, University of South Australia, Adelaide, South Australia, Australia Abstract: Low back pain (LBP is a major health issue with significant socioeconomic implications in most Western countries. Many forms of treatment have been proposed and investigated in the past, with exercise being a commonly prescribed intervention. Within allied health, in particular physiotherapy, there has been a growing movement that recognizes the role of the McKenzie method in treating LBP. Within the McKenzie framework, directional preference (DP exercises are one such intervention, with preliminary data demonstrating its effectiveness in the management of LBP. In this paper, we aim to integrate the evidence from current research, identified using a systematic review, and utilize a practical real-life case scenario to outline how evidence from the literature can be implemented in clinical practice. The findings from the systematic review indicate that DP exercises may have positive effects in the management of LBP. While the body of evidence to support this is limited (only four studies and therefore modest at best, it does provide some emerging evidence to support the use of DP exercises in clinical practice. Despite this, gaps also persist in the literature on DP exercises, and this relates to the exercise parameters and the compliance rates. Recognizing this dichotomy (modest evidence in some areas and evidence gaps in other areas, which is likely to confront health practitioners, using a practical approach with a real-life clinical scenario, we outline how the evidence from the systematic review can be implemented in clinical practice. This approach builds on the philosophy of evidence-based practice of integrating research evidence with clinical expertise and patient values. Keywords: low back pain, McKenzie method, directional

  10. McDonald’s as a Cultural Brand in the Landscape of Attitudes of Polish Customers

    Directory of Open Access Journals (Sweden)

    Marcin Komańda

    2016-01-01

    Full Text Available Purpose of the article: The analysis of the attitudes of Polish customers towards McDonald’s based on the identification of opposite social attitudes towards globalisation processes and perception of cultural brands. Methodology/methods: The qualitative analysis of the record of Internet users’ discussion has been conducted. The record of the discussion shall be regarded as an expression of opinion by an incidental group of respondents. For the purposes of the conducted research programmes weftQDA 1.0.1 and QSR NVIVO 10 have been used. Scientific aim: Utilization of postmodern interpretation of the socio-cultural context of running business for purposes of strategic management. Findings: The main differences between the supporters of the attitudes towards McDonald’s were related to two problems. Firstly, the discussion concerns what McDonald’s really is (how its service should be classified. Secondly, the thread of the discourse concerns the quality of McDonald’s offer. Further discussion involved the issues of impact of McDonald’s on the domestic business, and lifestyle of contemporary Poles and their dining habits. Conclusions: The landscape of attitudes of Polish customers towards McDonald’s is the issue of uncertainty in the strategic management within this company. It seems there is a need for paying attention to national cultural features of Poles and different attitudes of contemporary society expressed as a postmodern response to globalisation. Each group of problems mentioned may become an opportunity or a threat for McDonald’s business activity in Poland.

  11. McGovern-Dole International Food for Education and Child Nutrition Program. Fact Sheet

    Science.gov (United States)

    US Department of Agriculture, 2009

    2009-01-01

    The McGovern-Dole International Food for Education and Child Nutrition Program (McGovern-Dole program) helps support education, child development, and food security for some of the world's poorest children. It provides for donations of U.S. agricultural products, as well as financial and technical assistance, for school feeding and maternal and…

  12. A Comparative Study of McDonald's Wedding Narratives with the Model of Anchoring

    Science.gov (United States)

    Huang, Mimi

    2016-01-01

    Fast-food giant McDonald's announced in 2010 that they would start hosting wedding ceremonies and receptions for couples who would like to get married in their restaurants in Hong Kong. This paper conducts a study comparing the differing representations of McDonald's wedding services through a narrative analytical approach. Specifically, this…

  13. Evaluation of the Eclipse eMC algorithm for bolus electron conformal therapy using a standard verification dataset.

    Science.gov (United States)

    Carver, Robert L; Sprunger, Conrad P; Hogstrom, Kenneth R; Popple, Richard A; Antolak, John A

    2016-05-08

    The purpose of this study was to evaluate the accuracy and calculation speed of electron dose distributions calculated by the Eclipse electron Monte Carlo (eMC) algorithm for use with bolus electron conformal therapy (ECT). The recent com-mercial availability of bolus ECT technology requires further validation of the eMC dose calculation algorithm. eMC-calculated electron dose distributions for bolus ECT have been compared to previously measured TLD-dose points throughout patient-based cylindrical phantoms (retromolar trigone and nose), whose axial cross sections were based on the mid-PTV (planning treatment volume) CT anatomy. The phantoms consisted of SR4 muscle substitute, SR4 bone substitute, and air. The treatment plans were imported into the Eclipse treatment planning system, and electron dose distributions calculated using 1% and processors (Intel Xeon E5-2690, 2.9 GHz) on a framework agent server (FAS). In comparison, the eMC was significantly more accurate than the pencil beam algorithm (PBA). The eMC has comparable accuracy to the pencil beam redefinition algorithm (PBRA) used for bolus ECT planning and has acceptably low dose calculation times. The eMC accuracy decreased when smoothing was used in high-gradient dose regions. The eMC accuracy was consistent with that previously reported for accuracy of the eMC electron dose algorithm and shows that the algorithm is suitable for clinical implementation of bolus ECT.

  14. Sean McCarthy 7. raamprogrammi teemaline koolitus / Meelis Kadaja

    Index Scriptorium Estoniae

    Kadaja, Meelis, 1979-

    2006-01-01

    28. novembril Tallinnas toimunud koolitusest, mille eesmärgiks oli anda juhiseid konkurentsivõimelise projektitaotluse kirjutamiseks Euroopa Liidu seitsmendasse raamprogrammi ja mille viis läbi Sean McCarthy Iirimaalt

  15. Ead McTaggart: Using VBA to Automate EAD Container List Tagging

    Directory of Open Access Journals (Sweden)

    Randall Miles

    2009-11-01

    Full Text Available Faced with the prospect of converting 200-page container lists to Encoded Archival Description (EAD, the author programmed a Microsoft Access® database using Visual Basic for Applications (VBA to automatically insert the necessary EAD tags and their attributes. Some work is still required to ensure that the container list is properly formatted before importing into the database. Once formatted, the database, named Ead McTaggart, will convert a 7,000 line Microsoft Excel® container list, where each line represents a series, sub-series, or folder title, into a properly tagged EAD container list in about five minutes. As written, Ead McTaggart will handle up to six component levels, but can be modified to handle more. Although many institutions use Archivists' Toolkit or Archon for this functionality, many libraries and archives who have not implemented those tools will find that EAD McTaggert minimizes the work of converting existing container lists to EAD finding aids with a low time investment for implementation.

  16. Henry VIII, McLeod syndrome and Jacquetta's curse.

    Science.gov (United States)

    Stride, P; Lopes Floro, K

    2013-01-01

    The mental decline of King Henry VIII from being a jovial, charismatic and athletic young man into an increasingly paranoid, brutal tyrant in later life, ever more concerned at his lack of one or more male heirs, has attracted many medical diagnostic theories. Previous hypotheses have included diabetes, syphilis and hypothyroidism, among others. However, these inadequately explain Henry's failure to produce a male heir, despite multiple pairings. The latest postulated diagnoses for Henry are the coexistence of both Kell blood group antigenicity (possibly inherited from Jacquetta Woodville, Henry's maternal great grandmother) causing related impaired fertility, and McLeod syndrome, causing psychotic changes. As the mutated McLeod protein of the syndrome significantly reduces the expression, effectively inactivating the Kell antigen, we critically review this theory, examining in detail the pathophysiology of these conditions and assessing the genealogy of Henry VIII and its effect in subsequent generations.

  17. Designing new guides and instruments using McStas

    CERN Document Server

    Farhi, E; Wildes, A R; Ghosh, R; Lefmann, K

    2002-01-01

    With the increasing complexity of modern neutron-scattering instruments, the need for powerful tools to optimize their geometry and physical performances (flux, resolution, divergence, etc.) has become essential. As the usual analytical methods reach their limit of validity in the description of fine effects, the use of Monte Carlo simulations, which can handle these latter, has become widespread. The McStas program was developed at Riso National Laboratory in order to provide neutron scattering instrument scientists with an efficient and flexible tool for building Monte Carlo simulations of guides, neutron optics and instruments. To date, the McStas package has been extensively used at the Institut Laue-Langevin, Grenoble, France, for various studies including cold and thermal guides with ballistic geometry, diffractometers, triple-axis, backscattering and time-of-flight spectrometers. In this paper, we present some simulation results concerning different guide geometries that may be used in the future at th...

  18. The McDonald Observatory lunar laser ranging project

    Science.gov (United States)

    Silverberg, E. C.

    1978-01-01

    A summary of the activities of the McDonald lunar laser ranging station at Fort Davis for the FY 77-78 fiscal year is presented. The lunar laser experiment uses the observatory 2.7m reflecting telescope on a thrice-per-day, 21-day-per-lunation schedule. Data are recorded on magnetic tapes and sent to the University of Texas at Austin where the data is processed. After processing, the data is distributed to interested analysis centers and later to the National Space Science Data Center where it is available for routine distribution. Detailed reports are published on the McDonald operations after every fourth lunation or approximately once every 115 days. These reports contain a day-by-day documentation of the ranging activity, detailed discussions of the equipment development efforts, and an abundance of other information as is needed to document and archive this important data type.

  19. Subcarrier Group Assignment for MC-CDMA Wireless Networks

    Directory of Open Access Journals (Sweden)

    Le-Ngoc Tho

    2007-01-01

    Full Text Available Two interference-based subcarrier group assignment strategies in dynamic resource allocation are proposed for MC-CDMA wireless systems to achieve high throughput in a multicell environment. Least interfered group assignment (LIGA selects for each session the subcarrier group on which the user receives the minimum interference, while best channel ratio group assignment (BCRGA chooses the subcarrier group with the largest channel response-to-interference ratio. Both analytical framework and simulation model are developed for evaluation of throughput distribution of the proposed schemes. An iterative approach is devised to handle the complex interdependency between multicell interference profiles in the throughput analysis. Illustrative results show significant throughput improvement offered by the interference-based assignment schemes for MC-CDMA multicell wireless systems. In particular, under low loading conditions, LIGA renders the best performance. However, as the load increases BCRGA tends to offer superior performance.

  20. Subcarrier Group Assignment for MC-CDMA Wireless Networks

    Directory of Open Access Journals (Sweden)

    Tho Le-Ngoc

    2007-12-01

    Full Text Available Two interference-based subcarrier group assignment strategies in dynamic resource allocation are proposed for MC-CDMA wireless systems to achieve high throughput in a multicell environment. Least interfered group assignment (LIGA selects for each session the subcarrier group on which the user receives the minimum interference, while best channel ratio group assignment (BCRGA chooses the subcarrier group with the largest channel response-to-interference ratio. Both analytical framework and simulation model are developed for evaluation of throughput distribution of the proposed schemes. An iterative approach is devised to handle the complex interdependency between multicell interference profiles in the throughput analysis. Illustrative results show significant throughput improvement offered by the interference-based assignment schemes for MC-CDMA multicell wireless systems. In particular, under low loading conditions, LIGA renders the best performance. However, as the load increases BCRGA tends to offer superior performance.

  1. Lucky Mc Uranium Mill. Draft environmental statement

    International Nuclear Information System (INIS)

    1977-06-01

    The Environmental Impact Statement addressed the following: the existing environment; operations; environmental impacts; environmental effects of accidents; monitoring programs and other mitigating measures; unavoidable adverse environmental impacts; relationship between short-term uses of the environment and long-term productivity; irreversible and irretrievable commitments of resources; alternatives; and NRC benefit-cost summary for the Lucky Mc Mill

  2. Reversible Low-Light Induced Photoswitching of Crowned Spiropyran-DO3A Complexed with Gadolinium(III Ions

    Directory of Open Access Journals (Sweden)

    André Knoesen

    2012-05-01

    Full Text Available Photoswitchable spiropyran has been conjugated to the crowned ring system DO3A, which improves its solubility in dipolar and polar media and stabilizes the merocyanine isomer. Adding the lanthanide ion gadolinium(III to the macrocyclic ring system leads to a photoresponsive magnetic resonance imaging contrast agent that displays an increased spin-lattice relaxation time (T1 upon visible light stimulation. In this work, the photoresponse of this photochromic molecule to weak light illumination using blue and green light emitting diodes was investigated, simulating the emission spectra from bioluminescent enzymes. Photon emission rate of the light emitting diodes was changed, from 1.75 × 1016 photons·s−1 to 2.37 × 1012 photons·s−1. We observed a consistent visible light-induced isomerization of the merocyanine to the spiropyran form with photon fluxes as low as 2.37 × 1012 photons·s−1 resulting in a relaxivity change of the compound. This demonstrates the potential for use of the described imaging probes in low light level applications such as sensing bioluminescence enzyme activity. The isomerization behavior of gadolinium(III-ion complexed and non-complexed spiropyran-DO3A was analyzed in water and ethanol solution in response to low light illumination and compared to the emitted photon emission rate from over-expressed Gaussia princeps luciferase.

  3. McDonald's läks maja pärast kohtusse / Vahur Koorits

    Index Scriptorium Estoniae

    Koorits, Vahur, 1981-

    2008-01-01

    Ilmunud ka: Postimees : na russkom jazõke 13. veebr. 2008, lk. 3. McDonaldþsi toidukohti pidava firma Premier Restaurants Eesti AS arvates on tal õigus küsida teistelt samas majas paiknevatelt asutustelt üüri ning nõuab saamata jäänud raha eest üle 8 miljoni krooni kahjutasu. Vt. samas: Viru 24; Lao tõstis McDonaldsi töötajad tänavale

  4. Poetic justice: A commentary on Joseph B. McCaffrey's "The brain’s heterogeneous landscape"

    Directory of Open Access Journals (Sweden)

    Witold Hensel

    2015-12-01

    Full Text Available The paper is a commentary on McCaffrey (2015. I begin by arguing that the two views on brain pluripotency that McCaffrey intends to reconcile, namely those of Price and Friston (2005 and Klein (2012, are not really in conflict. The alleged disagreement between them stems from two interpretative failures: first on the part of Klein, who has misrepresented the views of Price and Friston, and second on the part of McCaffrey, who has misconstrued Klein’s position. I then take issue with McCaffrey’s claim that each of the structurefunction mapping strategies he discusses allows researchers to discover a different kind of pluripotency: (1 where each subregion of a pluripotent brain area performs a specific function, (2 where a brain area performs a single function in multiple mechanisms (networks, and (3 where a brain area performs multiple functions in multiple mechanisms (networks.

  5. Designing new guides and instruments using McStas

    DEFF Research Database (Denmark)

    Farhi, E.; Hansen, T.; Wildes, A.

    2002-01-01

    of guides, neutron optics and instruments [1]. To date, the McStas package has been extensively used at the Institut Laue-Langevin, Grenoble, France, for various studies including cold and thermal guides with ballistic geometry, diffractometers, triple-axis, backscattering and time-of-flight spectrometers...

  6. Joseph McCabe: A Forgotten Early Populariser of Science and Defender of Evolution

    Science.gov (United States)

    Cooke, Bill

    2010-01-01

    Joseph McCabe (1867-1955) was one of the most prolific and gifted polymaths of the twentieth century. Long before such a thing was thought respectable, and almost a century before any university established a chair in the public understanding of science, McCabe made a living as a populariser of science and a critic of philosophical and religious…

  7. Oblicza wojny w kontekście teorii mediów Marshalla McLuhana

    Directory of Open Access Journals (Sweden)

    Kalina Kukiełko-Rogozińska

    2017-12-01

    Full Text Available Faces of war in the context of Marshall McLuhan's media theory The article shows how Marshall McLuhan’s media theory is used to analyze photographs taken with an iPhone. The reflections were inspired by the blog of the Canadian photographer Rita Leistner, who participated in the media project aimed at familiarizing American soldiers’ families and friends with everyday life of the military contingent in Afghanistan. Leistner, for the first time in her career, used a smartphone instead of professional photographic equipment. Her decision was motivated by the need to edit photographs easily and publish them quickly on the Internet. The result of her work was a blog, titled Looking for Marshall McLuhan in Afghanistan. To describe her photographs, Leistner uses selected concepts defined by McLuhan in the second half of the 20th century: probe, extension of man or figure-background dichotomy. In consequence, the technological face of war can be better understood by the viewers of the materials she prepared.   Oblicza wojny w kontekście teorii mediów Marshalla McLuhana W artykule przedstawiono sposób wykorzystania teorii mediów Marshalla McLuhana do analizy zdjęć wykonanych iPhone’em. Inspiracją do tych rozważań jest blog kanadyjskiej fotografki Rity Leistner, uczestniczki projektu medialnego, którego celem było zapoznanie rodzin i przyjaciół amerykańskich żołnierzy z codziennym życiem wojskowego kontyngentu w Afganistanie. Leistner, po raz pierwszy w karierze, używała smartfonu zamiast profesjonalnego sprzętu fotograficznego. Wynikało to z konieczności łatwego edytowania zdjęć i ich szybkiego umieszczania w internecie. Efektem tej pracy jest blog zatytułowany Looking for Marshall McLuhan in Afghanistan. Aby opisać swoje fotografie, Leistner użyła bowiem wybranych koncepcji sformułowanych przez kanadyjskiego myśliciela w drugiej połowie XX wieku: sondy, przedłużenia człowieka czy dychotomii figura/tło. Dzi

  8. Short Form-McGill Pain Questionnaire-2 (SF-MPQ-2: A Cross-Cultural Adaptation and Validation Study of the Persian Version in Patients with Knee Osteoarthritis

    Directory of Open Access Journals (Sweden)

    Amir Reza Kachooei

    2015-01-01

    Full Text Available Background: We aimed to develop and validate the Persian version of Short Form McGill Pain Questionnaire-2 (SF-MPQ-2 in patients with knee osteoarthritis. Methods: Translation and back translation was performed using Beaton’s guideline. After a consensus has achieved on the Persian version of SF-MPQ-2, it was administered to 30 patients with knee osteoarthritis in a pilot study. Then, we enrolled 100 patients with knee osteoarthritis to fill the final SF-MPQ-2 as well as SF-36 and WOMAC questionnaires. Forty-three patients returned 3 days after the initial visit to fill the Persian SF-MPQ-2 for the second time. Construct validity was tested by Pearson’s correlation coefficient between subscales of SF-MPQ-2 and subscales of SF-36 and WOMAC. Internal consistency for total and subscales was calculated by Cronbach’s alpha and reliability between test retest was performed using Intraclass correlation coefficient (ICC. Results: ICC for subscales of SF-MPQ-2 ranged from 0.73 to 0.90. The ICC for total SF-MPQ-2 was 0.90. Cronbach’s alpha for subscales was 0.65-0.74 at the first visit and 0.58-0.81 at the second visit. Cronbach’s alpha for the total questionnaire was 0.88 and 0.91 at the first and second visit, respectively. Pearson’s correlation coefficient was highly significant when comparing subscales specifically with WOMAC (r=-0.47 to -0.61; P

  9. Short Form-McGill Pain Questionnaire-2 (SF-MPQ-2: A Cross-Cultural Adaptation and Validation Study of the Persian Version in Patients with Knee Osteoarthritis

    Directory of Open Access Journals (Sweden)

    Amir Reza Kachooei

    2015-01-01

    Background: We aimed to develop and validate the Persian version of Short Form McGill Pain Questionnaire-2 (SF-MPQ-2 in patients with knee osteoarthritis. Methods: Translation and back translation was performed using Beaton’s guideline. After a consensus has achieved on the Persian version of SF-MPQ-2, it was administered to 30 patients with knee osteoarthritis in a pilot study. Then, we enrolled 100 patients with knee osteoarthritis to fill the final SF-MPQ-2 as well as SF-36 and WOMAC questionnaires. Forty-three patients returned 3 days after the initial visit to fill the Persian SF-MPQ-2 for the second time. Construct validity was tested by Pearson’s correlation coefficient between subscales of SF-MPQ-2 and subscales of SF-36 and WOMAC. Internal consistency for total and subscales was calculated by Cronbach’s alpha and reliability between test retest was performed using Intraclass correlation coefficient (ICC. Results: ICC for subscales of SF-MPQ-2 ranged from 0.73 to 0.90. The ICC for total SF-MPQ-2 was 0.90. Cronbach’s alpha for subscales was 0.65-0.74 at the first visit and 0.58-0.81 at the second visit. Cronbach’s alpha for the total questionnaire was 0.88 and 0.91 at the first and second visit, respectively. Pearson’s correlation coefficient was highly significant when comparing subscales specifically with WOMAC (r=-0.47 to -0.61; P

  10. Hybrid appendectomy with classic trocar on McBurney's point.

    Science.gov (United States)

    Gunes, Mehmet Emin; Ersoz, Feyzullah; Duzkoylu, Yigit; Arikan, Soykan; Cakir, Coskun; Nayci, Ali Emre

    2018-03-01

    Appendectomy is still the most commonly performed intra-abdominal operation worldwide. Interestingly, it has not reached the same popularity as other laparoscopic surgical procedures. Although multiple techniques have been described, a standard approach has not been described for the laparoscopic technique yet. To perform hybrid appendectomy for acute appendicitis on McBurney's point, aiming to perform an easier and quicker procedure while limiting the trauma to the abdominal wall by obtaining the advantages of both laparoscopic and open techniques. We retrospectively evaluated the results of 24 patients on whom we had performed hybrid appendectomy with an optical trocar on McBurney's point for acute appendicitis in 1 year in terms of demographics, operative time, complications, hospital stay and cosmetic results. Twenty-one of the patients underwent hybrid appendectomy with a one-optic trocar on McBurney's point. The mean operative time was 21.4 ±6.2 min. We did not encounter any postoperative complications in any of the patients. The median hospital stay was 1.2 ±1.0 days. The postoperative scar was minimal. This technique is defined in the literature for the first time, and it is easy and feasible for the surgeons. It may reduce the operative time and costs when compared to the conventional laparoscopic technique, but prospective studies with more patients are needed for more certain results.

  11. Interactions between brown bears and chum salmon at McNeil River, Alaska

    Science.gov (United States)

    Peirce, Joshua M.; Otis, Edward O.; Wipfli, Mark S.; Follmann, Erich H.

    2013-01-01

    Predation on returning runs of adult salmon (Oncorhynchus spp.) can have a large influence on their spawning success. At McNeil River State Game Sanctuary (MRSGS), Alaska, brown bears (Ursus arctos) congregate in high numbers annually along the lower McNeil River to prey upon returning adult chum salmon (O. keta). Low chum salmon escapements into McNeil River since the late 1990s have been proposed as a potential factor contributing to concurrent declines in bear numbers. The objective of this study was to determine the extent of bear predation on chum salmon in McNeil River, especially on pre-spawning fish, and use those data to adjust the escapement goal for the river. In 2005 and 2006, 105 chum salmon were radiotagged at the river mouth and tracked to determine cause and location of death. Below the falls, predators consumed 99% of tagged fish, killing 59% of them before they spawned. Subsequently, the escapement goal was nearly doubled to account for this pre-spawning mortality and to ensure enough salmon to sustain both predators and prey. This approach to integrated fish and wildlife management at MRSGS can serve as a model for other systems where current salmon escapement goals may not account for pre-spawning mortality.

  12. Kinematic analysis of melange fabrics: Examples and applications from the McHugh Complex, Kenai Peninsula, Alaska

    Science.gov (United States)

    Kusky, T.M.; Bradley, D.C.

    1999-01-01

    Permian to Cretaceous melange of the McHugh Complex on the Kenai Peninsula, south-central Alaska includes blocks and belts of graywacke, argillite, limestone, chert, basalt, gabbro, and ultramafic rocks, intruded by a variety of igneous rocks. An oceanic plate stratigraphy is repeated hundreds of times across the map area, but most structures at the outcrop scale extend lithological layering. Strong rheological units occur as blocks within a matrix that flowed around the competent blocks during deformation, forming broken formation and melange. Deformation was noncoaxial, and disruption of primary layering was a consequence of general strain driven by plate convergence in a relatively narrow zone between the overriding accretionary wedge and the downgoing, generally thinly sedimented oceanic plate. Soft-sediment deformation processes do not appear to have played a major role in the formation of the melange. A model for deformation at the toe of the wedge is proposed in which layers oriented at low angles to ??1 are contracted in both the brittle and ductile regimes, layers at 30-45??to ??1 are extended in the brittle regime and contracted in the ductile regime, and layers at angles greater than 45??to ??1 are extended in both the brittle and ductile regimes. Imbrication in thrust duplexes occurs at deeper levels within the wedge. Many structures within melange of the McHugh Complex are asymmetric and record kinematic information consistent with the inferred structural setting in an accretionary wedge. A displacement field for the McHugh Complex on the lower Kenai Peninsula includes three belts: an inboard belt of Late Triassic rocks records west-to-east-directed slip of hanging walls, a central belt of predominantly Early Jurassic rocks records north-south directed displacements, and Early Cretaceous rocks in an outboard belt preserve southwest-northeast directed slip vectors. Although precise ages of accretion are unknown, slip directions are compatible with

  13. The osmotic second virial coefficient and the Gibbs-McMillan-Mayer framework

    DEFF Research Database (Denmark)

    Mollerup, J.M.; Breil, Martin Peter

    2009-01-01

    The osmotic second virial coefficient is a key parameter in light scattering, protein crystallisation. self-interaction chromatography, and osmometry. The interpretation of the osmotic second virial coefficient depends on the set of independent variables. This commonly includes the independent...... variables associated with the Kirkwood-Buff, the McMillan-Mayer, and the Lewis-Randall solution theories. In this paper we analyse the osmotic second virial coefficient using a Gibbs-McMillan-Mayer framework which is similar to the McMillan-Mayer framework with the exception that pressure rather than volume...... is an independent variable. A Taylor expansion is applied to the osmotic pressure of a solution where one of the solutes is a small molecule, a salt for instance, that equilibrates between the two phases. Other solutes are retained. Solvents are small molecules that equilibrate between the two phases...

  14. Astronauts McDivitt and White look over training plans

    Science.gov (United States)

    1965-01-01

    Astronauts James A. McDivitt (left) and Edward H. White II are shown looking over training plans at Cape Kennedy during prelaunch preparations. The NASA Headquarters alternative photo number is 65-H-275.

  15. McArdle disease does not affect skeletal muscle fibre type profiles in humans

    Directory of Open Access Journals (Sweden)

    Tertius Abraham Kohn

    2014-11-01

    Full Text Available Patients suffering from glycogen storage disease V (McArdle disease were shown to have higher surface electrical activity in their skeletal muscles when exercising at the same intensity as their healthy counterparts, indicating more muscle fibre recruitment. To explain this phenomenon, this study investigated whether muscle fibre type is shifted towards a predominance in type I fibres as a consequence of the disease. Muscle biopsies from the Biceps brachii (BB (n = 9 or Vastus lateralis (VL (n = 8 were collected over a 13-year period from male and female patients diagnosed with McArdle disease, analysed for myosin heavy chain (MHC isoform content using SDS-PAGE, and compared to healthy controls (BB: n = 3; VL: n = 10. All three isoforms were expressed and no difference in isoform expression in VL was found between the McArdle patients and healthy controls (MHC I: 33±19% vs. 43±7%; MHC IIa: 52±9% vs. 40±7%; MHC IIx: 15±18% vs. 17±9%. Similarly, the BB isoform content was also not different between the two groups (MHC I: 33±14% vs. 30±11%; MHC IIa: 46±17% vs. 39±5%; MHC IIx: 21±13% vs. 31±14%. In conclusion, fibre type distribution does not seem to explain the higher surface EMG in McArdle patients. Future studies need to investigate muscle fibre size and contractility of McArdle patients.

  16. Using McIDAS-V data analysis and visualization software as an educational tool for understanding the atmosphere

    Science.gov (United States)

    Achtor, T. H.; Rink, T.

    2010-12-01

    The University of Wisconsin’s Space Science and Engineering Center (SSEC) has been at the forefront in developing data analysis and visualization tools for environmental satellites and other geophysical data. The fifth generation of the Man-computer Interactive Data Access System (McIDAS-V) is Java-based, open-source, freely available software that operates on Linux, Macintosh and Windows systems. The software tools provide powerful new data manipulation and visualization capabilities that work with geophysical data in research, operational and educational environments. McIDAS-V provides unique capabilities to support innovative techniques for evaluating research results, teaching and training. McIDAS-V is based on three powerful software elements. VisAD is a Java library for building interactive, collaborative, 4 dimensional visualization and analysis tools. The Integrated Data Viewer (IDV) is a reference application based on the VisAD system and developed by the Unidata program that demonstrates the flexibility that is needed in this evolving environment, using a modern, object-oriented software design approach. The third tool, HYDRA, allows users to build, display and interrogate multi and hyperspectral environmental satellite data in powerful ways. The McIDAS-V software is being used for training and education in several settings. The McIDAS User Group provides training workshops at its annual meeting. Numerous online tutorials with training data sets have been developed to aid users in learning simple and more complex operations in McIDAS-V, all are available online. In a University of Wisconsin-Madison undergraduate course in Radar and Satellite Meteorology, McIDAS-V is used to create and deliver laboratory exercises using case study and real time data. At the high school level, McIDAS-V is used in several exercises in our annual Summer Workshop in Earth and Atmospheric Sciences to provide young scientists the opportunity to examine data with friendly and

  17. McConnell Sign in a Patient with Massive Acute Pulmonary Embolism

    Directory of Open Access Journals (Sweden)

    Qaiser Shafiq

    2011-01-01

    Full Text Available A 48-year-old female was admitted after experiencing a brief syncopal episode. Three weeks ago the patient sustained a right arm humerus bone fracture in a motor vehicle accident. Since the accident, her mobility has been limited. CT angiogram of the chest revealed massive bilateral pulmonary emboli. A 2D echocardiogram was performed, which demonstrated McConnell sign and severe right ventricle dysfunction. Considering potential of hemodynamic instability, the patient received fibrinolytic therapy with Alteplase. A subsequent 2D echocardiogram showed complete resolution of McConnell sign and right ventricle dysfunction.

  18. Mouth reversal extinguishes mismatch negativity induced by the McGurk illusion

    DEFF Research Database (Denmark)

    Eskelund, Kasper; Andersen, Tobias

    2013-01-01

    The sight of articulatory mouth movements (visual speech) influences auditory speech perception. This is demonstrated by the McGurk illusion in which incongruent visual speech alters the auditory phonetic percept. In behavioral studies, reversal of the vertical mouth direction has been reported...... by visual speech with either upright (unaltered) or vertically reversed mouth area. In a preliminary analysis, we found a Mismatch Negativity component induced by the McGurk illusion for 6 of 17 participants at electrode Cz when the mouth area was upright. In comparison, these participants produced...

  19. Test pilots 1962 - Armstrong, Walker, Dana, Peterson, McKay, Thompson, Butchart

    Science.gov (United States)

    1962-01-01

    The research pilots at what in 1962 was called the Flight Research Center standing in front of the X-1E. They are (left to right) Neil Armstrong, Joe Walker, Bill Dana, Bruce Peterson, Jack McKay, Milt Thompson, and Stan Butchart. of the group, Armstrong, Walker, Dana, McKay and Thompson all flew the X-15. Bruce Peterson flew the M2-F2 and HL-10 lifting bodies, while Stan Butchart was the B-29 drop plane pilot for many of the D-558-II and X-1 series research aircraft.

  20. Association Between MC-2 Peptide and Hepatic Perfusion and Liver Injury Following Resuscitated Hemorrhagic Shock.

    Science.gov (United States)

    Matheson, Paul J; Fernandez-Botran, Rafael; Smith, Jason W; Matheson, Samuel A; Downard, Cynthia D; McClain, Craig J; Garrison, Richard N

    2016-03-01

    Hemorrhagic shock (HS) due to trauma remains a major cause of morbidity and mortality in the United States, despite continuing progression of advanced life support and treatment. Trauma is the third most common cause of death worldwide and is the leading cause of death in the 1- to 44-year-old age group. Hemorrhagic shock often progresses to multiple organ failure despite conventional resuscitation (CR) that restores central hemodynamics. To examine whether MC-2 would bind glycosaminoglycans to decrease proinflammatory cytokines' influence in the liver, minimize organ edema, prevent liver injury, and improve hepatic perfusion. MC-2, a synthetic octapeptide derived from the heparin-binding domain of murine interferon gamma (IFN-γ), binds glycosaminoglycans to modulate serum and interstitial cytokine levels and activity. A controlled laboratory study of 3y male Sprague-Dawley rats that were randomized to 4 groups of 8 each: sham, sham+MC-2 (50 mg/kg), HS/CR, or HS/CR+MC-2 (HS = 40% of baseline mean arterial pressure for 60 minutes; CR = return of shed blood and 2 volumes of saline). The study began in March, 2013. Effective hepatic blood flow (EHBF) by galactose clearance, wet-dry weights, cytokines, histopathology, complete metabolic panel, and complete blood cell count were performed at 4 hours after CR. MC-2 partially reversed the HS/CR-induced hepatic hypoperfusion at 3 and 4 hours postresuscitation compared with HS/CR alone. Effective hepatic blood flow decreased during the HS period from a mean (SD) of 7.4 (0.3) mL/min/100 g and 7.5 (0.5) mL/min/100g at baseline to 3.7 (0.4) mL/min/100g and 5.9 (0.5) mL/min/100g for the HS/CR and HS/CR+MC-2 groups, respectively (P hepatic blood flow remained constant in the sham groups throughout the experimental protocol. Organ edema was increased in the ileum and liver in the HS/CR vs sham group, and MC-2 decreased edema in the ileum vs the HS/CR group. MC-2 in HS also decreased levels of alanine aminotransferase

  1. Orion star-forming region - far-infrared and radio molecular observations

    International Nuclear Information System (INIS)

    Thronson, H.A. Jr.; Harper, D.A.; Bally, J.; Dragovan, M.; Mozurkewich, D.; Yerkes Observatory, Williams Bay, WI; ATandT Bell Labs., Holmdel, NJ; Chicago Uni., IL; E. O. Hulburt Center for Space Research, Washington, DC)

    1986-01-01

    New J = 1-0 CO and far-infrared maps of the Orion star-forming region are presented and discussed. The total infrared luminosity of the Orion star-forming ridge is 250,000 solar luminosities. The material that is emitting strongly at 60 microns is traced and found to be highly centrally concentrated. However, the majority of the extended emission from this region comes from dust that is ultimately heated by the visible Trapezium cluster stars. The luminosity of IRc 2, the most luminous member of the infrared cluster, is estimated to be 40,000-50,000 solar luminosities. A schematic drawing of the Ori MC 1 region is presented. 30 references

  2. MC-50 AVF cyclotron operation

    Energy Technology Data Exchange (ETDEWEB)

    Chae, Jong Seo; Lee, Dong Hoon; Kim, You Seok; Park, Chan Won; Lee, Yong Min; Hong, Sung Seok; Lee, Min Yong

    1995-12-01

    The first cyclotron in Korea, MC-59 cyclotron is used for neutron irradiation, radionuclide development, production and material and biomedical research. 50.5MeV and 35MeV proton beam have been extracted with 20-70 .mu.A. A total of beam extraction time are 1095.7 hours. 206.5 hours are used for the developments and 663.8 hours are for radionuclide production and development and 225.4 hours for application researches. The shutdown days are 23days. Fundamental data for failure decrement and efficient beam extraction were composed and maintenance technologies were developed. (author). 8 tabs., 17 figs., 10 refs.

  3. MC-50 AVF cyclotron operation

    International Nuclear Information System (INIS)

    Kim, Yu Seok; Chai, Jong Seo; Bak, Seong Ki; Park, Chan Won; Jo, Young Ho; Hong, Seong Seok; Lee, Min Yong; Jang Ho Ha

    2000-01-01

    The first cyclotron in Korea, MC-50 cyclotron is used for neutron irradiation, radionuclide development, production and material and biomedical research. 50.5MeV and 35MeV proton beam have been extracted with 20-60μA. A total of beam extraction time are 1095.7 hours. 206.5 hours are used for the developments and 663.8 hours are for radionuclide production and development and 225.4 hours for application researches. The shutdown days are 23 days. Fundamental data for failure decrement and efficient beam extraction were composed and maintenance technologies were developed

  4. MC-50 AVF cyclotron operation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yu Seok; Chai, Jong Seo; Bak, Seong Ki; Park, Chan Won; Jo, Young Ho; Hong, Seong Seok; Lee, Min Yong; Jang Ho Ha

    2000-01-01

    The first cyclotron in Korea, MC-50 cyclotron is used for neutron irradiation, radionuclide development, production and material and biomedical research. 50.5MeV and 35MeV proton beam have been extracted with 20-60{mu}A. A total of beam extraction time are 1095.7 hours. 206.5 hours are used for the developments and 663.8 hours are for radionuclide production and development and 225.4 hours for application researches. The shutdown days are 23 days. Fundamental data for failure decrement and efficient beam extraction were composed and maintenance technologies were developed.

  5. MC-50 AVF cyclotron operation

    International Nuclear Information System (INIS)

    Chae, Jong Seo; Lee, Dong Hoon; Kim, You Seok; Park, Chan Won; Lee, Yong Min; Hong, Sung Seok; Lee, Min Yong.

    1995-12-01

    The first cyclotron in Korea, MC-59 cyclotron is used for neutron irradiation, radionuclide development, production and material and biomedical research. 50.5MeV and 35MeV proton beam have been extracted with 20-70 .mu.A. A total of beam extraction time are 1095.7 hours. 206.5 hours are used for the developments and 663.8 hours are for radionuclide production and development and 225.4 hours for application researches. The shutdown days are 23days. Fundamental data for failure decrement and efficient beam extraction were composed and maintenance technologies were developed. (author). 8 tabs., 17 figs., 10 refs

  6. Development and benchmark of high energy continuous-energy neutron cross Section library HENDL-ADS/MC

    International Nuclear Information System (INIS)

    Chen Chong; Wang Minghuang; Zou Jun; Xu Dezheng; Zeng Qin

    2012-01-01

    The ADS (accelerator driven sub-critical system) has great energy spans, complex energy spectrum structures and strong physical effects. Hence, the existing nuclear data libraries can't fully meet the needs of nuclear analysis in ADS. In order to do nuclear analysis for ADS system, a point-wise data library HENDL-ADS/MC (hybrid evaluated nuclear data library) was produced by FDS team. Meanwhile, to test the availability and reliability of the HENDL-ADS/MC data library, a series of shielding and critical safety benchmarks were performed. To validate and qualify the reliability of the high-energy cross section for HENDL-ADS/MC library further, a series of high neutronics integral experiments have been performed. The testing results confirm the accuracy and reliability of HENDL-ADS/MC. (authors)

  7. Studies of tt+cc production with MadGraph5_aMC@NLO and Herwig++ for the ATLAS experiment

    CERN Document Server

    The ATLAS collaboration

    2016-01-01

    Studies of the simulation of ttcc at the LHC, at a centre-of-mass energy of 13 TeV, based on next-to-leading order calculations with MadGraph5_aMC@NLO matched to Herwig++ are presented. Samples with ttcc in the three flavour scheme, in a next-to-leading order matrix element are compared to an inclusive tt sample with the charm contribution coming from the parton shower. The effects of generator-level cuts, the functional form of the renormalization and factorization scales, and the starting scale of the parton shower are investigated.

  8. The McGurk Illusion in the Oddity Task

    DEFF Research Database (Denmark)

    Andersen, Tobias

    2010-01-01

    Despite many studies of audiovisual integration in speech perception very few studies have addressed the issue of cross- modal response bias. Using synthetic acoustic speech, the current study demonstrates the McGurk illusion in the oddity task which is not prone to cross-modal response bias...

  9. 75 FR 80742 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-12-23

    ...-1202; Directorate Identifier 2010-NM-167-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... amends Sec. 39.13 by adding the following new airworthiness directive (AD): McDonnell Douglas Corporation... Douglas Corporation Model MD-90-30 airplanes, certificated in any category. Subject (d) Joint Aircraft...

  10. 34 CFR 647.1 - What is the Ronald E. McNair Postbaccalaureate Achievement Program?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What is the Ronald E. McNair Postbaccalaureate... (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION RONALD E. MCNAIR POSTBACCALAUREATE ACHIEVEMENT PROGRAM General § 647.1 What is the Ronald E. McNair Postbaccalaureate Achievement Program? The...

  11. The McNair Scholars Program as an Agent of Socialization in the Doctoral Experience

    Science.gov (United States)

    Gittens, Cheryl Bailey

    2013-01-01

    Interventions such as the Ronald E. McNair Post-Baccalaureate Achievement Program (McNair Scholars Program) are among the national strategies for promoting doctoral degree attainment amongst first-generation college students from low socioeconomic backgrounds or groups underrepresented in graduate education. This study aimed to understand how…

  12. Solar Imagery - Photosphere - Sunspot Drawings - McMath-Hulbert Observatory

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The McMath-Hulbert Observatory is a decommissioned solar observatory in Lake Angelus, Michigan, USA. It was established in 1929 as a private observatory by father...

  13. Joseph McCabe: A Forgotten Early Populariser of Science and Defender of Evolution

    Science.gov (United States)

    Cooke, Bill

    2010-05-01

    Joseph McCabe (1867-1955) was one of the most prolific and gifted polymaths of the twentieth century. Long before such a thing was thought respectable, and almost a century before any university established a chair in the public understanding of science, McCabe made a living as a populariser of science and a critic of philosophical and religious obscurantism. Through the first half of the twentieth century he wrote countless cheap and widely distributed books and pamphlets for those whose thirst for knowledge exceeded the money or time they could devote to such pursuits. This article will detail, and give some assessment of, McCabe’s career as a populariser of science and expositor of evolutionary theory and its philosophical, religious and cultural ramifications.

  14. 75 FR 36577 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-06-28

    ... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 90-30 Airplanes AGENCY: Federal Aviation... Douglas Corporation: Docket No. FAA-2010-0554; Directorate Identifier 2010-NM-082-AD. Comments Due Date (a... supersedes AD 2009-07-04, Amendment 39-15863. Applicability (c) This AD applies to McDonnell Douglas...

  15. A Response to Stewart, McElwee, and Ming

    Science.gov (United States)

    Martin, Garry L.; Yu, C. T.

    2010-01-01

    In a recent article published in "The Behavior Analyst," Stewart, McElwee, and Ming (2010) suggested that "scientific experts in scientific contexts" should use more "technically accurate and precise labeling" when describing the Assessment of Basic Learning Abilities (ABLA) in published articles. They concluded by stating, "We believe that…

  16. On the absence of McShane-type identities for the outer space

    OpenAIRE

    Kapovich, Ilya; Rivin, Igor

    2008-01-01

    A remarkable result of McShane states that for a punctured torus with a complete finite volume hyperbolic metric we have \\[ \\sum_{\\gamma} \\frac{1}{e^{\\ell(\\gamma)}+1}={1/2} \\] where $\\gamma$ varies over the homotopy classes of essential simple closed curves and $\\ell(\\gamma)$ is the length of the geodesic representative of $\\gamma$. We prove that there is no reasonable analogue of McShane's identity for the Culler-Vogtmann outer space of a free group.

  17. The pathogenomics of McArdle disease-genes, enzymes, models, and therapeutic implication

    OpenAIRE

    Nogales-Gadea, Gisela; Santalla Hernández, Alfredo; Brull, Astrid; Luna, Noemí de; Lucía Mulas, Alejandro; Pinós, Tomás

    2015-01-01

    Numerous biomedical advances have been made since Carl and Gerty Cori discovered the enzyme phosphorylase in the 1940s and the Scottish physician Brian McArdle reported in 1951 a previously 'undescribed disorder characterized by a gross failure of the breakdown in muscle of glycogen'. Today we know that this disorder, commonly known as 'McArdle disease', is caused by inherited deficiency of the muscle isoform of glycogen phosphorylase (GP). Here we review the main aspects of the 'pathogenomic...

  18. Using McStas for modelling complex optics, using simple building bricks

    International Nuclear Information System (INIS)

    Willendrup, Peter K.; Udby, Linda; Knudsen, Erik; Farhi, Emmanuel; Lefmann, Kim

    2011-01-01

    The McStas neutron ray-tracing simulation package is a versatile tool for producing accurate neutron simulations, extensively used for design and optimization of instruments, virtual experiments, data analysis and user training. In McStas, component organization and simulation flow is intrinsically linear: the neutron interacts with the beamline components in a sequential order, one by one. Historically, a beamline component with several parts had to be implemented with a complete, internal description of all these parts, e.g. a guide component including all four mirror plates and required logic to allow scattering between the mirrors. For quite a while, users have requested the ability to allow 'components inside components' or meta-components, allowing to combine functionality of several simple components to achieve more complex behaviour, i.e. four single mirror plates together defining a guide. We will here show that it is now possible to define meta-components in McStas, and present a set of detailed, validated examples including a guide with an embedded, wedged, polarizing mirror system of the Helmholtz-Zentrum Berlin type.

  19. McDonald 2.1-m and CRTS Photometry of Eclipsing Polars

    Science.gov (United States)

    Wells, Natalie; Mason, Paul

    2018-01-01

    We present broadband optical photometry of five polars made using the 2.1-m telescope of McDonald Observatory. Four of the polars are eclipsing (EP Dra, FL Cet, V2301 Oph, and a Catalina Sky Survey (CSS) polar candidate). In addition, a pre-polar (MQ Dra) was observed. Typical integration times were 1-3 seconds with no dead time. At this time resolution, eclipse structure can be seen in both one- and two-pole accretors. McDonald 2.1-m data over several years is phased together with CSS photometry covering up to 7 years, in search of indications of period variation. Combining the high-resolution, high-speed photometry obtained using the ProEm camera on the McDonald 2.1-m with the sparse, but high-quality multi-year baseline photometry of the CSS places strong constraints on the time variability of the eclipse periods in these binary systems. In most cases, eclipse variations do not perfectly fit a linear ephemeris. We investigate the source of variations using standard O-C diagram techniques and period search algorithms.

  20. McMaster Mesonet soil moisture dataset: description and spatio-temporal variability analysis

    Directory of Open Access Journals (Sweden)

    K. C. Kornelsen

    2013-04-01

    Full Text Available This paper introduces and describes the hourly, high-resolution soil moisture dataset continuously recorded by the McMaster Mesonet located in the Hamilton-Halton Watershed in Southern Ontario, Canada. The McMaster Mesonet consists of a network of time domain reflectometer (TDR probes collecting hourly soil moisture data at six depths between 10 cm and 100 cm at nine locations per site, spread across four sites in the 1250 km2 watershed. The sites for the soil moisture arrays are designed to further improve understanding of soil moisture dynamics in a seasonal climate and to capture soil moisture transitions in areas that have different topography, soil and land cover. The McMaster Mesonet soil moisture constitutes a unique database in Canada because of its high spatio-temporal resolution. In order to provide some insight into the dominant processes at the McMaster Mesonet sites, a spatio-temporal and temporal stability analysis were conducted to identify spatio-temporal patterns in the data and to suggest some physical interpretation of soil moisture variability. It was found that the seasonal climate of the Great Lakes Basin causes a transition in soil moisture patterns at seasonal timescales. During winter and early spring months, and at the meadow sites, soil moisture distribution is governed by topographic redistribution, whereas following efflorescence in the spring and summer, soil moisture spatial distribution at the forested site was also controlled by vegetation canopy. Analysis of short-term temporal stability revealed that the relative difference between sites was maintained unless there was significant rainfall (> 20 mm or wet conditions a priori. Following a disturbance in the spatial soil moisture distribution due to wetting, the relative soil moisture pattern re-emerged in 18 to 24 h. Access to the McMaster Mesonet data can be provided by visiting www.hydrology.mcmaster.ca/mesonet.

  1. MC-DS-CDMA System based on DWT and STBC in ITU Multipath Fading Channels Model

    Directory of Open Access Journals (Sweden)

    Nader Abdullah Khadam

    2018-03-01

    Full Text Available In this paper, the performance of multicarrier direct sequence code division multiple access (MC-DS-CDMA in fixed MC-DS-CDMA and Mobile MC-DS-CDMA applications have been improved by using the compensations of space time block coding and Discrete Fast Fourier transforms (FFT or Discrete Wavelets transform DWT. These MC-DS-CDMA systems had been simulated using MATLAB 2015a. Through simulation of the proposed system, various parameters can be changed and tested. The Bit Error Rate (BERs of these systems are obtained over wide range of signal to noise ratio. All simulation results had been compared with each other using different subcarrier size of FFT or DWT with STBC for 1,2,3 and 4 antennas in transmitter and under different ITU multipath fading channels and different Doppler frequencies (fd. The proposed structures of STBC-MC-DS-CDMA system based on (DWT batter than based on (FFT in varies Doppler frequencies and subcarrier size. Also, proposed system with STBC based on 4 transmitters better than other systems based on 1 or 2 or 3 transmitters in all Doppler frequencies and subcarrier size in all simulation results.

  2. Interfacing MCNPX and McStas for simulation of neutron transport

    DEFF Research Database (Denmark)

    Klinkby, Esben Bryndt; Lauritzen, Bent; Nonbøl, Erik

    2013-01-01

    Stas[4, 5, 6, 7]. The coupling between the two simulation suites typically consists of providing analytical fits of MCNPX neutron spectra to McStas. This method is generally successful but has limitations, as it e.g. does not allow for re-entry of neutrons into the MCNPX regime. Previous work to resolve......Simulations of target-moderator-reflector system at spallation sources are conventionally carried out using Monte Carlo codes such as MCNPX[1] or FLUKA[2, 3] whereas simulations of neutron transport from the moderator and the instrument response are performed by neutron ray tracing codes such as Mc...... geometries, backgrounds, interference between beam-lines as well as shielding requirements along the neutron guides....

  3. STS-74 Mission Specialists McArther and Ross in OPF

    Science.gov (United States)

    1995-01-01

    In Orbiter Processing Facility Bay 2, STS-74 Mission Specialist William 'Bill' McArthur Jr. (left) and Jerry L. Ross are reviewing the configuration of payload elements in the orbiter Atlantis' payload bay. Ross and McArthur are participating in the Crew Equipment Interface Test (CEIT), an opportunity for flight crew members to become familiar with the payload hardware they will be working with on-orbit. Located in Atlantis' payload bay are the Orbiter Docking System and the Docking Module, two pieces of flight hardware that will play a crucial role in the second docking of the Space Shuttle to the Russian Space Station Mir. STS-74 is currently targeted for an early November launch

  4. Reproduction impairment and endocrine disruption in female zebrafish after long-term exposure to MC-LR: A life cycle assessment

    International Nuclear Information System (INIS)

    Hou, Jie; Li, Li; Wu, Ning; Su, Yujing; Lin, Wang; Li, Guangyu; Gu, Zemao

    2016-01-01

    Microcystin-LR (MC-LR) has been found to cause reproductive and developmental impairments as well as to disrupt sex hormone homeostasis of fish during acute and sub-chronic toxic experiments. However, fish in natural environments are continuously exposed to MC-LR throughout their entire life cycle as opposed to short-term exposure. Here, we tested the hypothesis that the mechanism by which MC-LR harms female fish reproduction and development within natural water bodies is through interference of the reproductive endocrine system. In the present study, zebrafish hatchlings (5 d post-fertilization) were exposed to 0, 0.3, 3 and 30 μg/L MC-LR for 90 d until reaching sexual maturity. Female zebrafish were selected, and the changes in growth and developmental indicators, ovarian ultrastructure as well as the levels of gonadal steroid hormones and vitellogenin (VTG) were examined along with the transcription of related genes in the hypothalamic–pituitary–gonadal–liver axis (HPGL-axis). The results showed for the first time, a life cycle exposure to MC-LR caused growth inhibition, decreased ovary weight and ovarian ultra-pathological lesions. Decreased ovarian testosterone levels indicated that MC-LR disrupted sex steroid hormone balance. Significantly up-regulated transcription of brain FSHβ and LHβ along with ovarian ERα, FSHR and LHR suggested positive feedback regulation in the HPGL-axis was induced as a compensatory mechanism for MC-LR damage. It was also noted that ovarian VTG content and hepatic ERα and VTG1 expression were all down-regulated, which might be responsible for reduced vitellus storage noted in our histological observations. Our findings indicate that a life cycle exposure to MC-LR impairs the development and reproduction of female zebrafish by disrupting the transcription of related HPGL-axis genes, suggesting that MC-LR has potential adverse effects on fish reproduction and thus population dynamics in MCs-contaminated aquatic

  5. Mini-Proceedings of the 15th Meeting of the Working Group on Rad : Corrections and MC Generators for Low Energies

    CERN Document Server

    Venanzoni, G

    2014-01-01

    The mini-proceedings of the 15th Meeting of the "Working Group on Rad. Corrections and MC Generators for Low Energies" held in Mainz on April 11, 2014, are presented. These meetings, started in 2006, have as aim to bring together experimentalists and theorists working in the fields of meson transition form factors, hadronic contributions to $(g-2)_\\mu$ and the effective fine structure constant, and development of Monte Carlo generators and Radiative Corrections for precision e+e- and tau physics.

  6. Up through the Ranks at McDonnell Douglas.

    Science.gov (United States)

    Settle, Mary

    1989-01-01

    Raher than bemoan the lack of leadership potential among younger employees, McDonnell Douglas Corporation has embarked on a comprehensive strategy of on-the-job development for staff members at all levels of the organization. Three types of rotational training are being used to address corporate, functional, and intracompany needs. (Author)

  7. Duplicating MC-15 Output with Python and MCNP

    Energy Technology Data Exchange (ETDEWEB)

    McSpaden, Alexander Thomas [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-08-23

    Two Python scripts have been written that process the output files of MCNP6 into a format that mimics the list-mode output of Los Alamos National Laboratory’s MC-15 and NPOD neutron detection systems. This report details the methods implemented in these scripts and instructions on their use.

  8. Experimental study of biotin-avidin pretargeting technique for anti-CEA McAb radioimmunoimaging

    International Nuclear Information System (INIS)

    Sun Jianzhong; Zhu Chengmo; Guan Liang; Li Biao; Zhang Jixian; Shi Ailan; Zhang Suyin

    1996-01-01

    Biotin-avidin pretargeting technique was used in promoting the diagnostic efficacy of anti-CEA McAb radioimmunoimaging. CEA McAb was conjugated with biotin McAb (B-McAb), streptavidin (SA) was labeled with 131 I ( 131 I-SA) and DTPA-biotin with 111 In( 111 In-DTPA-B). Experimental human colonic tumor bearing nude mice were used. Two step method: B-McAb was preinjected, followed by 131 I SA 48h later, 24, 48, 96 and 120 h postinjection, γ-imaging and biodistribution were studied. Three step method: B-McAb was preinjected, followed by cold SA 24h later and 111 In-DTPA-B another 24h later. 2,6,24 and 48h postinjection, γ-imaging and biodistribution were also studied. Two step method: T/NT of all organs in experimental group was significantly increased compared with controls. The blood T/NT in experimental group and control group at 24 and 120h was 1.11:0.42 and 8.58:3.51, respectively. Tumor % ID/g in all organs slightly decreased compared with direct group. In γ-imaging radioactivity has been accumulated in tumor site as early as 24h, while only slightly visualized or non-visualized in controls. Three step method: in experimental group the blood T/NT reached 4.19 at 2 h, whereas all was < 1.37 at each phase of controls, the T/NT of all organs was also higher in experimental grouped than in controls. The tumor % ID/g in experimental group was 9.72% at 2h and 3.65% at 48h whereas % ID/g in controls in all phases was <3.07. The tumor clearly visualized at 2h and clearer at 48h in γ-imaging. In controls, the tumor was slightly visualized also to early stage, but faded away later on. Biotin-avidin pretargeting technique can elevate the T/NT ratio and decrease the blood background. Early imaging was obtained with better imaging quality

  9. Reports of MC and A system design workshop subgroups

    International Nuclear Information System (INIS)

    Hatcher, C.R.

    1984-01-01

    A summary of subgroup reports from the workshop on design of a materials control and accounting system for a low-enrichment fuel fabrication facility is presented. Responses to a MC and A design system questionnaire are also summarized

  10. What Costs Do Reveal and Moving beyond the Cost Debate: Reply to Einstein and McDaniel (2010)

    Science.gov (United States)

    Smith, Rebekah E.

    2010-01-01

    Einstein et al. (2005) predicted no cost to an ongoing task when a prospective memory task met certain criteria. Smith, Hunt, McVay, and McConnell (2007) used prospective memory tasks that met these criteria and found a cost to the ongoing task, contrary to Einstein et al.'s prediction. Einstein and McDaniel (2010) correctly noted that there are…

  11. MC and A instrumentation catalog

    Energy Technology Data Exchange (ETDEWEB)

    Neymotin, L. [ed.] [Brookhaven National Lab., Upton, NY (United States); Sviridova, V. [ed.] [All-Russian Research Inst. of Automatics, Moscow (Russian Federation)

    1998-06-01

    In 1981 and 1985, two editions of a catalog of non-destructive nuclear measurement instrumentation, and material control and surveillance equipment, were published by Brookhaven National Laboratory (BNL). The last edition of the catalog included one hundred and twenty-five entries covering a wide range of devices developed in the US and abroad. More than ten years have elapsed since the publication of the more recent Catalog. Devices described in it have undergone significant modifications, and new devices have been developed. Therefore, in order to assist specialists in the field of Material Control and Accounting (MC and A), a new catalog has been created. Work on this instrumentation catalog started in 1997 as a cooperative effort of Brookhaven National Laboratory (BNL), operated by Brookhaven Science Associates under contract to the US Department of Energy, and the All-Russian Research Institute of Automatics (VNIIA), subordinate institute of the Atomic Energy Ministry of the Russian Federation, within the collaborative US-Russia Material Protection, Control, and Accounting (MPC and A) Program. Most of the equipment included in the Catalog are non-destructive assay (NDA) measurement devices employed for purposes of accounting, confirmation, and verification of nuclear materials. Other devices also included in the Catalog are employed in the detection and deterrence of unauthorized access to or removal of nuclear materials (material control: containment and surveillance). Equipment found in the Catalog comprises either: (1) complete devices or systems that can be used for MC and A applications; or (2) parts or components of complete systems, such as multi-channel analyzers, detectors, neutron generators, and software. All devices are categorized by their status of development--from prototype to serial production.

  12. MC and A instrumentation catalog

    International Nuclear Information System (INIS)

    Neymotin, L.; Sviridova, V.

    1998-01-01

    In 1981 and 1985, two editions of a catalog of non-destructive nuclear measurement instrumentation, and material control and surveillance equipment, were published by Brookhaven National Laboratory (BNL). The last edition of the catalog included one hundred and twenty-five entries covering a wide range of devices developed in the US and abroad. More than ten years have elapsed since the publication of the more recent Catalog. Devices described in it have undergone significant modifications, and new devices have been developed. Therefore, in order to assist specialists in the field of Material Control and Accounting (MC and A), a new catalog has been created. Work on this instrumentation catalog started in 1997 as a cooperative effort of Brookhaven National Laboratory (BNL), operated by Brookhaven Science Associates under contract to the US Department of Energy, and the All-Russian Research Institute of Automatics (VNIIA), subordinate institute of the Atomic Energy Ministry of the Russian Federation, within the collaborative US-Russia Material Protection, Control, and Accounting (MPC and A) Program. Most of the equipment included in the Catalog are non-destructive assay (NDA) measurement devices employed for purposes of accounting, confirmation, and verification of nuclear materials. Other devices also included in the Catalog are employed in the detection and deterrence of unauthorized access to or removal of nuclear materials (material control: containment and surveillance). Equipment found in the Catalog comprises either: (1) complete devices or systems that can be used for MC and A applications; or (2) parts or components of complete systems, such as multi-channel analyzers, detectors, neutron generators, and software. All devices are categorized by their status of development--from prototype to serial production

  13. Maiorana-McFarland class: Degree optimization and algebraic properties

    DEFF Research Database (Denmark)

    Pasalic, Enes

    2006-01-01

    degree of functions in the extended Maiorana-McFarland (MM) class (nonlinear resilient functions F : GF (2)(n) -> GF (2)(m) derived from linear codes). We also show that in the Boolean case, the same subclass seems not to have an optimized algebraic immunity, hence not providing a maximum resistance......In this paper, we consider a subclass of the Maiorana-McFarland class used in the design of resilient nonlinear Boolean functions. We show that these functions allow a simple modification so that resilient Boolean functions of maximum algebraic degree may be generated instead of suboptimized degree...... in the original class. Preserving a high-nonlinearity value immanent to the original construction method, together with the degree optimization gives in many cases functions with cryptographic properties superior to all previously known construction methods. This approach is then used to increase the algebraic...

  14. McCarthy's The Road and Ethical Choice in a Post-Apocalyptic World

    OpenAIRE

    Guo, Jingjing

    2015-01-01

    In her article "McCarthy's The Road and Ethical Choice in a Post-Apocalyptic World" Jingjing Guo analyses ethical choice and its implications in McCarthy's The Road. After examining the deterioration of the ethical context and the prevalence of evil reflected in cannibalism, Guo highlights the father's ethical choice and dilemma. Different from most others, the father chooses to keep alive to protect his son, and to stay man and stay good in a physically devastated and morally bankrupted worl...

  15. Comparison of Inflation Processes at the 1859 Mauna Loa Flow, HI, and the McCartys Flow Field, NM

    Science.gov (United States)

    Bleacher, Jacob E.; Garry, W. Brent; Zimbelman, James R.; Crumpler, Larry S.

    2012-01-01

    Basaltic lavas typically form channels or tubes during flow emplacement. However, the importance of sheet flow in the development of basalt ic terrains received recognition over the last 15 years. George Walke r?s research on the 1859 Mauna Loa Flow was published posthumously in 2009. In this paper he discusses the concept of endogenous growth, or inflation, for the distal portion of this otherwise channeldominated lava flow. We used this work as a guide when visiting the 1859 flow to help us better interpret the inflation history of the McCartys flow field in NM. Both well preserved flows display similar clues about the process of inflation. The McCartys lava flow field is among the you ngest (approx.3000 yrs) basaltic lava flows in the continental United States. It was emplaced over slopes of <1 degree, which is similar to the location within the 1859 flow where inflation occurred. Although older than the 1859 flow, the McCartys is located in an arid environ ment and is among the most pristine examples of sheet flow morphologies. At the meter scale the flow surface typically forms smooth, undula ting swales that create a polygonal terrain. The literature for simil ar features includes multiple explanatory hypotheses, original breakouts from adjacent lobes, or inflation related upwarping of crust or sa gging along fractures that enable gas release. It is not clear which of these processes is responsible for polygonal terrains, and it is po ssible that one explanation is not the sole cause of this morphology between all inflated flows. Often, these smooth surfaces within an inflated sheet display lineated surfaces and occasional squeeze-ups alon g swale contacts. We interpret the lineations to preserve original fl ow direction and have begun mapping these orientations to better interpret the emplacement history. At the scale of 10s to 100s of meters t he flow comprises multiple topographic plateaus and depressions. Some depressions display level floors with

  16. Effect of changes in fat availability on exercise capacity in McArdle disease

    DEFF Research Database (Denmark)

    Andersen, S.T.; Jeppesen, T.D.; Taivassalo, T.

    2009-01-01

    for oxidation during exercise. DESIGN: Randomized, placebo-controlled, crossover trial. SETTING: Hospitalized care. PATIENTs: Ten patients (8 men and 2 women) with McArdle disease. INTERVENTIONS: Patients cycled at a constant workload corresponding to 70% of their maximum oxygen consumption. In random order......Ardle disease, but maximal rates of fat oxidation seem limited and cannot be increased above physiologically normal rates during exercise. This limitation is probably caused by a metabolic bottleneck in the tricarboxylic acid cycle due to impaired glycolytic flux in McArdle disease. Therapies aimed at enhancing......BACKGROUND: The major fuel for exercising muscle at low exercise intensities is fat. OBJECTIVE: To investigate the role of fat metabolism in McArdle disease (also known as glycogen storage disease type V), an inborn error of muscle glycogenolysis, by manipulating free fatty acid availability...

  17. Testing the McSad depression specific classification system in patients with somatic conditions: validity and performance.

    Science.gov (United States)

    Papageorgiou, Katerina; Vermeulen, Karin M; Schroevers, Maya J; Buskens, Erik; Ranchor, Adelita V

    2013-07-26

    Valuations of depression are useful to evaluate depression interventions offered to patients with chronic somatic conditions. The only classification system to describe depression developed specifically for valuation purposes is the McSad, but it has not been used among somatic patients. The aim of this study was to test the construct validity of the McSad among diabetes and cancer patients and then to compare the McSad to the commonly used EuroQol - 5 Dimensions (EQ-5DTM) classification system. The comparison was expected to shed light on their capacity to reflect the range of depression states experienced by somatic patients. Cross-sectional data were collected online from 114 diabetes and 195 cancer patients; additionally, 241 cancer patients completed part of the survey on paper. Correlational analyses were performed to test the construct validity. Specifically, we hypothesized high correlations of the McSad domains with depression (Center for Epidemiological Studies Depression Scale (CES-D) and the Patient Health Questionnaire (PHQ-9)). We also expected low/moderate correlations with self-esteem (Rosenberg Self-Esteem scale - RSE) and extraversion (Eysenck Personality Questionnaire Extraversion scale - EPQ-e). Multiple linear regression analyses were run so that the proportion of variance in depression scores (CES-D, PHQ-9) explained by the McSad could be compared to the proportion explained by the EQ-5D classification system. As expected, among all patients groups, we found moderate to high correlations for the McSad domains with the CES-D (.41 to .70) and the PHQ-9 (.52 to .76); we also found low to moderate correlations with the RSE (-.21 to .-48) and the EPQ-e (.18 to .31). Linear regression analyses showed that the McSad explained a greater proportion of variance in depression (CES-D, PHQ-9) (Diabetes: 73%, 82%; Cancer: 72%, 72%) than the EQ-5D classification system (Diabetes: 47%, 59%; Cancer: 51%, 47%). Findings support the construct validity of the Mc

  18. Third party testing : new pilot facility for mining processes opens in Fort McKay

    International Nuclear Information System (INIS)

    Jaremko, D.

    2007-01-01

    Fort McKay lies 65 kilometres north of Fort McMurray, Alberta and is the centre of operational oilsands mining activity. As such, it was chosen for a pilot testing facility created by the Geneva-based SGS Group. The reputable facility provides an opportunity for mining producers to advance their processes, including environmental performance, by allowing them to test different processes on their own oilsands. The Northern Lights partnership, led by Synenco Energy, was the first client at the facility. Due to outsourcing, clients are not obligated to make substantial capital investment into in-house research. The Northern Lights partnership will be using the facility to test extraction processes on bitumen from its leases. Although the Fort McKay facility is SGS's first venture into the oilsands industry, it operates in more than 140 companies globally, including the mineral industry, and specializes in inspection, verification, testing and certification. SGS took the experience from its minerals extraction business to identify what could be done to help the oilsands industry by using best practices developed from global operations. The facility lies on the Fort McKay industrial park owned by the Fort McKay First Nation. An existing testing facility called McMurray Resources Research and Testing was expanded by the SGS Group to include environmental analysis capabilities. The modular units that lie on 6 acres include refrigerated ore storage to maintain ore integrity; modular ore and materials handling systems; extraction equipment; and, zero discharge process water and waste disposal systems. Froth treatment will be added in the near future to cover the entire upstream side of the mining processing business. A micro-upgrader might be added in the future to manufacture synthetic crude. 3 figs

  19. Third party testing : new pilot facility for mining processes opens in Fort McKay

    Energy Technology Data Exchange (ETDEWEB)

    Jaremko, D.

    2007-12-15

    Fort McKay lies 65 kilometres north of Fort McMurray, Alberta and is the centre of operational oilsands mining activity. As such, it was chosen for a pilot testing facility created by the Geneva-based SGS Group. The reputable facility provides an opportunity for mining producers to advance their processes, including environmental performance, by allowing them to test different processes on their own oilsands. The Northern Lights partnership, led by Synenco Energy, was the first client at the facility. Due to outsourcing, clients are not obligated to make substantial capital investment into in-house research. The Northern Lights partnership will be using the facility to test extraction processes on bitumen from its leases. Although the Fort McKay facility is SGS's first venture into the oilsands industry, it operates in more than 140 companies globally, including the mineral industry, and specializes in inspection, verification, testing and certification. SGS took the experience from its minerals extraction business to identify what could be done to help the oilsands industry by using best practices developed from global operations. The facility lies on the Fort McKay industrial park owned by the Fort McKay First Nation. An existing testing facility called McMurray Resources Research and Testing was expanded by the SGS Group to include environmental analysis capabilities. The modular units that lie on 6 acres include refrigerated ore storage to maintain ore integrity; modular ore and materials handling systems; extraction equipment; and, zero discharge process water and waste disposal systems. Froth treatment will be added in the near future to cover the entire upstream side of the mining processing business. A micro-upgrader might be added in the future to manufacture synthetic crude. 3 figs.

  20. Brief Analysis On Different Organizational Behaviors Between Wal-Mart and McDonald's

    Institute of Scientific and Technical Information of China (English)

    全毅文

    2009-01-01

    @@ At present, increasing companies appeared on the market, and market is just like a big melting furnace. If company can not lay out themselves, company will be eliminated. Many of companies are out of use in the market, but the Walmart and McDonald's talented showing itself in numerous markets and held water in this melting furnace. And how did they achieve their success? General speaking, the organizational structure, culture and perfect management are the most important factors for the two companies. In my report, I will use the Walmart and McDonald's case and compare the two companies' different cultures, structures and managements, and begin to describe the three areas. First chapter will talk about companies' background. Second part will describe the comparison of companies. And third chapter will discuss the development of companies. Now we will walk into the world of Walmart and McDonald, and experience the success of the two enterprises jointly.

  1. McGee Creek Drainage and Levee District, Illinois.

    Science.gov (United States)

    1973-04-01

    J COUNTY MC GEE REEK DRAINAGE BLEVEE DISTRICT N~ i, 0. ~ I I LEGEND Co ,. 3 ~ . -~------~----EXISTING LEVEE _____________PROPOSED LEVEE...Development, Conservation, Environmental Protection Agency, Health, Institute for Environmental Quality, Mines and Minerals. Pollution Control Board...Protection Agency, Health, Institute for Environmental Quality, Mines and Minerals, Pollution Control Board, Registration and Education, Transportation

  2. Application of the MCNPX-McStas interface for shielding calculations and guide design at ESS

    DEFF Research Database (Denmark)

    Klinkby, Esben Bryndt; Bergbäck Knudsen, Erik; Willendrup, Peter Kjær

    2013-01-01

    . The generation and moderation of neutrons is simulated using a full scale MCNPX model of the ESS target monolith. Upon entering the beam extraction region, the individual neutron states are handed to McStas via the MCNPX-McStas interface. McStas transports the neutrons through the beam guide and by using newly......Recently, an interface between the Monte Carlo code MCNPX and the neutron ray-tracing code MCNPX was developed[1]. Based on the expected neutronic performance and guide geometries relevant for the ESS, the combined MCNPX-McStas code is used to calculate dose rates along neutron beam guides...... developed event logging capability, the neutron state parameters corresponding to un-reflected neutrons are recorded at each scattering. This information is handed back to MCNPX where it serves as neutron source input for a second MCNPX simulation. This simulation enables calculation of dose rates...

  3. VALIDATION OF NUCLEAR MATERIAL CONTROL AND ACCOUNTABILITY (MC and A) SYSTEM EFFECTIVENESS TOOL (MSET) AT IDAHO NATIONAL LABORATORY (INL)

    International Nuclear Information System (INIS)

    Meppen, Bruce; Haga, Roger; Moedl, Kelley; Bean, Tom; Sanders, Jeff; Thom, Mary Alice

    2008-01-01

    A Nuclear Material Control and Accountability (MC and A) Functional Model has been developed to describe MC and A systems at facilities possessing Category I or II Special Nuclear Material (SNM). Emphasis is on achieving the objectives of 144 'Fundamental Elements' in key areas ranging from categorization of nuclear material to establishment of Material Balance Areas (MBAs), controlling access, performing quality measurements of inventories and transfers, timely reporting all activities, and detecting and investigating anomalies. An MC and A System Effectiveness Tool (MSET), including probabilistic risk assessment (PRA) technology for evaluating MC and A effectiveness and relative risk, has been developed to accompany the Functional Model. The functional model and MSET were introduced at the 48th annual International Nuclear Material Management (INMM) annual meeting in July, 20071,2. A survey/questionnaire is used to accumulate comprehensive data regarding the MC and A elements at a facility. Data is converted from the questionnaire to numerical values using the DELPHI method and exercises are conducted to evaluate the overall effectiveness of an MC and A system. In 2007 a peer review was conducted and a questionnaire was completed for a hypothetical facility and exercises were conducted. In the first quarter of 2008, a questionnaire was completed at Idaho National Laboratory (INL) and MSET exercises were conducted. The experience gained from conducting the MSET exercises at INL helped evaluate the completeness and consistency of the MC and A Functional Model, descriptions of fundamental elements of the MC and A Functional Model, relationship between the MC and A Functional Model and the MC and A PRA tool and usefulness of the MSET questionnaire data collection process

  4. 75 FR 47199 - Airworthiness Directives; McDonnell Douglas Corporation Model DC-9-10 Series Airplanes, DC-9-30...

    Science.gov (United States)

    2010-08-05

    ... Airworthiness Directives; McDonnell Douglas Corporation Model DC- 9-10 Series Airplanes, DC-9-30 Series... existing airworthiness directive (AD), which applies to all McDonnell Douglas Model DC-9-10 series..., 2010). That AD applies to all McDonnell Douglas Corporation Model DC-9-10 series airplanes, DC-9-30...

  5. Physical training for McArdle disease

    DEFF Research Database (Denmark)

    Quinlivan, Rosaline; Vissing, John; Hilton-Jones, David

    2011-01-01

    McArdle disease is a rare metabolic myopathy caused by a complete absence of the enzyme muscle glycogen phosphorylase. Affected people experience symptoms of fatigue and cramping within minutes of exercise and are at risk for acute muscle injury (rhabdomyolysis) and acute renal failure. If the fi....... If the first few minutes of exercise are paced, a 'second wind' will occur enabling exercise to continue. This is due to mobilisation and utilisation of alternative fuel substrates. Aerobic training appears to improve work capacity by increasing cardiovascular fitness....

  6. McKenzie River Focus Watershed Coordination: Fiscal Year 1998.

    Energy Technology Data Exchange (ETDEWEB)

    Runyon, John; Davis-Born, Renee

    1998-01-01

    This report summarizes accomplishments made by the McKenzie River Focus Watershed Council in the areas of coordination and administration during Fiscal Year 1998. Coordination and administration consists of tasks associated with Focus Watershed Council staffing, project management, and public outreach.

  7. On McShane integrability of Banach space-valued functions

    Czech Academy of Sciences Publication Activity Database

    Kurzweil, Jaroslav; Schwabik, Štefan

    2004-01-01

    Roč. 29, č. 2 (2004), s. 763-780 ISSN 0147-1937 R&D Projects: GA ČR GA201/01/1199 Institutional research plan: CEZ:AV0Z1019905 Keywords : McShane integral * vector integration Subject RIV: BA - General Mathematics

  8. The petrology, geochronology and significance of Granite Harbour Intrusive Complex xenoliths and outcrop sampled in western McMurdo Sound, Southern Victoria Land, Antarctica

    International Nuclear Information System (INIS)

    Martin, A.P.; Cooper, A.F.; Price, R.C.; Turnbull, R.E.; Roberts, N.M.W.

    2015-01-01

    Granite Harbour Intrusive Complex xenoliths in McMurdo Volcanic Group rocks and in situ outcrops have been studied from Mount Morning, western McMurdo Sound, Antarctica. Calc-alkalic samples have whole rock signatures and normative compositions similar to the Dry Valleys 1b suite, and zircon grains in one specimen yield a 545.2 ± 4.4 Ma crystallisation age. This supports subduction-related magmatism initiating in Southern Victoria Land by 545 Ma. A second group of xenoliths is alkalic, with titanite grains in one xenolith from this group dated at 538 ± 8 Ma. Whole rock chemistry, normative compositions and geochronology of the alkalic group are comparable to the Koettlitz Glacier Alkaline Suite (KGAS). The position of a proposed lower crustal discontinuity that may form a significant basement suture in the McMurdo Sound region is newly constrained to the east of Mount Morning, perhaps along the trace of the Discovery Glacier. The boundary between East and West Antarctica may also pass along the trace of the Discovery Glacier if, as previously hypothesised, its location is controlled by the basement suture. A significant basement suture may also have provided the necessary egress for the (regionally) early and sustained magmatic activity observed at Mount Morning over the last 24 million years. (author).

  9. Dr. David Sawyer, Mickey Mouse and Dr. David Brown attend a ceremony at Ronald McNair Middle School

    Science.gov (United States)

    1999-01-01

    Dr. David Sawyer (left), Superintendent of the Brevard County School District, Mickey Mouse, and Dr. David Brown, a NASA astronaut, attend a tribute to NASA astronaut Ronald McNair held in the gymnasium of Ronald McNair Magnet School in Cocoa, Fla. During the tribute, Walt Disney World presented a portrait of McNair to the school, which had previously been renamed for the fallen astronaut. McNair was one of a crew of seven who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

  10. Streptomyces sp. MC10 SUŞUNUN ALFA AMİLAZ ÜRETİM KABİLİYETİNİN BELİRLENMESİ - DETERMINATION OF ABILITY OF ALPHA AMYLASE PRODUCTION BY Streptomyces sp. MC10 STRAIN

    OpenAIRE

    ÖZDEMİR, Ali; SIDAL, Uğur

    2013-01-01

    Streptomyces sp. MC10 SUŞUNUN ALFA AMİLAZ ÜRETİM KABİLİYETİNİN BELİRLENMESİAmilazlar en önemli endüstriyel enzimlerden biridir. Amilaz üreticisi olan Streptomyces MC10 suşu Manisa Celal Bayar Üniversitesinden alınan toprak örneklerinden izole edilmiştir. Bu çalışmada Streptomyces MC10 suşundan α-amilaz üretimi ve karakterizasyonu gerçekleştirilmiştir. Bu amaçla suşun besiyerinde üremesi ve α-amilaz üretme yeteneği ve aktivite gösterdiği optimum sıcaklık, pH, inkübasyon süresi ve substrat kons...

  11. Bottom of the Iceberg: The Archontic Text - Review of Fanged Fan Fiction (McFarland, 2013)

    DEFF Research Database (Denmark)

    Schubart, Rikke

    2014-01-01

    Anmeldelse af Lindgren, Maria og Malin Isaksson, Fanged Fan Fiction: Variations on Twilight, True Blood and The Vampire Diaries (McFarland, 2013)......Anmeldelse af Lindgren, Maria og Malin Isaksson, Fanged Fan Fiction: Variations on Twilight, True Blood and The Vampire Diaries (McFarland, 2013)...

  12. Modelling hadronic interactions in HEP MC generators

    CERN Document Server

    Skands, Peter

    2015-01-01

    HEP event generators aim to describe high-energy collisions in full exclusive detail. They combine perturbative matrix elements and parton showers with dynamical models of less well-understood phenomena such as hadronization, diffraction, and the so-called underlying event. We briefly summarise some of the main concepts relevant to the modelling of soft/inclusive hadron interactions in MC generators, in particular PYTHIA, with emphasis on questions recently highlighted by LHC data.

  13. 75 FR 47203 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-11 and MD-11F Airplanes Equipped...

    Science.gov (United States)

    2010-08-05

    ... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 11 and MD-11F Airplanes Equipped With General... Sec. 39.13 by adding the following new AD: 2010-16-03 McDonnell Douglas Corporation: Amendment 39... applies to McDonnell Douglas Corporation Model MD-11 and MD-11F airplanes, certified in any category...

  14. Scintigraphic demonstration of a iatrogenic rhabdomyolysis im McArdle's syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Neumann, P.; Rumpf, K.W.; Kaiser, H.; Meinck, H.M.; Goebel, H.H.; Schicha, H.; Emrich, D.

    1982-02-01

    In a patient with late onset McArdle's disease local rhabdomyolysis and massive myoglobinuria were provoked by a routine diagnostic procedure - the forearm ischemic work test. Localisation and extent of rhabdomyolysis could be demonstrated by a conventional whole-body scanning technique using sup(99m)Tc methylenediphosphonate as a tracer. It is concluded that the forearm ischemic work test is not without risk in patients with McArdle's disease, and care should be taken to prevent myoglobinuric renal failure in these patients.

  15. Suomen McDonald’s-ketjun ravintolahenkilöstön sisäisen koulutuspolun mallintaminen

    OpenAIRE

    Baikov, Anne; Malaska, Mari; Räty, Isa

    2015-01-01

    Tämän opinnäytetyön tavoitteena on mallintaa Suomen McDonald’s-ketjun ravintolahenkilöstön sisäinen koulutuspolku. Koulutuspolku sisältää ravintolahenkilöstön koulutusohjelmat ravintolatyöntekijästä ravintolapäällikköön asti. Mallintamisprosessin lopputuote on produkti, Koulutuspolku-opas, joka avaa Suomen McDonald’s-ketjun eri koulutusohjelmien sisältöä sekä eri työtehtävissä edellytettävää osaamista. Produktin avainkohderyhmänä on Suomen McDonald’s-ketjun ravintolajohto. Työn toimeksian...

  16. Quality control of MC and A system and integrated safeguards

    International Nuclear Information System (INIS)

    Osabe, Takeshi

    2000-01-01

    In the integrated safeguards regime, co-operation with SSAC is a vital element to achieve efficiency of safeguards implementation while maintaining the effectiveness. However, the degree of co-operation fully depends upon the credibility, technical capability and the transparency of SSAC. Since the credibility of SSAC (States' System of Accounting for and Control of Nuclear Materials) depends heavily on effectiveness of facility operator's Material Control and Accounting (MC and A) practice, some measures to provide continuous assurance of the function and effectiveness of the system such as quality assurance program including periodical system audit (diagnostic) function ought to be established. This paper discusses quality assurance program for facility level MC and A including audit (diagnostic) method to maintain continuous assurance of the effectiveness. (author)

  17. Destructive Leadership: The Hatfield and McCoy Feud

    Science.gov (United States)

    Sparks, George; Wolf, Patricia; Zurick, Andryce M.

    2015-01-01

    This paper explores the phenomenon of destructive leadership using the historical case study of the feud between the Hatfields and McCoys. The characteristics of destructive leadership as well as the consequences of this leadership style are reviewed, examined and analyzed. Utilizing a case from history to shine light on a contemporary problem,…

  18. Local Thermodynamic Equilibrium in Laser-Induced Breakdown Spectroscopy: Beyond the McWhirter criterion

    International Nuclear Information System (INIS)

    Cristoforetti, G.; De Giacomo, A.; Dell'Aglio, M.; Legnaioli, S.; Tognoni, E.; Palleschi, V.; Omenetto, N.

    2010-01-01

    In the Laser-Induced Breakdown Spectroscopy (LIBS) technique, the existence of Local Thermodynamic Equilibrium (LTE) is the essential requisite for meaningful application of theoretical Boltzmann-Maxwell and Saha-Eggert expressions that relate fundamental plasma parameters and concentration of analyte species. The most popular criterion reported in the literature dealing with plasma diagnostics, and usually invoked as a proof of the existence of LTE in the plasma, is the McWhirter criterion [R.W.P. McWhirter, in: Eds. R.H. Huddlestone, S.L. Leonard, Plasma Diagnostic Techniques, Academic Press, New York, 1965, pp. 201-264]. However, as pointed out in several papers, this criterion is known to be a necessary but not a sufficient condition to insure LTE. The considerations reported here are meant to briefly review the theoretical analysis underlying the concept of thermodynamic equilibrium and the derivation of the McWhirter criterion, and to critically discuss its application to a transient and non-homogeneous plasma, like that created by a laser pulse on solid targets. Specific examples are given of theoretical expressions involving relaxation times and diffusion coefficients, as well as a discussion of different experimental approaches involving space and time-resolved measurements that could be used to complement a positive result of the calculation of the minimum electron number density required for LTE using the McWhirter formula. It is argued that these approaches will allow a more complete assessment of the existence of LTE and therefore permit a better quantitative result. It is suggested that the mere use of the McWhirter criterion to assess the existence of LTE in laser-induced plasmas should be discontinued.

  19. Dose rates from a C-14 source using extrapolation chamber and MC calculations

    International Nuclear Information System (INIS)

    Borg, J.

    1996-05-01

    The extrapolation chamber technique and the Monte Carlo (MC) calculation technique based on the EGS4 system have been studied for application for determination of dose rates in a low-energy β radiation field e.g., that from a 14 C source. The extrapolation chamber measurement method is the basic method for determination of dose rates in β radiation fields. Applying a number of correction factors and the stopping power ratio, tissue to air, the measured dose rate in an air volume surrounded by tissue equivalent material is converted into dose to tissue. Various details of the extrapolation chamber measurement method and evaluation procedure have been studied and further developed, and a complete procedure for the experimental determination of dose rates from a 14 C source is presented. A number of correction factors and other parameters used in the evaluation procedure for the measured data have been obtained by MC calculations. The whole extrapolation chamber measurement procedure was simulated using the MC method. The measured dose rates showed an increasing deviation from the MC calculated dose rates as the absorber thickness increased. This indicates that the EGS4 code may have some limitations for transport of very low-energy electrons. i.e., electrons with estimated energies less than 10 - 20 keV. MC calculations of dose to tissue were performed using two models: a cylindrical tissue phantom and a computer model of the extrapolation chamber. The dose to tissue in the extrapolation chamber model showed an additional buildup dose compared to the dose in the tissue model. (au) 10 tabs., 11 ills., 18 refs

  20. Binding and unbinding the auditory and visual streams in the McGurk effect.

    Science.gov (United States)

    Nahorna, Olha; Berthommier, Frédéric; Schwartz, Jean-Luc

    2012-08-01

    Subjects presented with coherent auditory and visual streams generally fuse them into a single percept. This results in enhanced intelligibility in noise, or in visual modification of the auditory percept in the McGurk effect. It is classically considered that processing is done independently in the auditory and visual systems before interaction occurs at a certain representational stage, resulting in an integrated percept. However, some behavioral and neurophysiological data suggest the existence of a two-stage process. A first stage would involve binding together the appropriate pieces of audio and video information before fusion per se in a second stage. Then it should be possible to design experiments leading to unbinding. It is shown here that if a given McGurk stimulus is preceded by an incoherent audiovisual context, the amount of McGurk effect is largely reduced. Various kinds of incoherent contexts (acoustic syllables dubbed on video sentences or phonetic or temporal modifications of the acoustic content of a regular sequence of audiovisual syllables) can significantly reduce the McGurk effect even when they are short (less than 4 s). The data are interpreted in the framework of a two-stage "binding and fusion" model for audiovisual speech perception.

  1. Stochastic approach to municipal solid waste landfill life based on the contaminant transit time modeling using the Monte Carlo (MC) simulation

    International Nuclear Information System (INIS)

    Bieda, Bogusław

    2013-01-01

    The paper is concerned with application and benefits of MC simulation proposed for estimating the life of a modern municipal solid waste (MSW) landfill. The software Crystal Ball® (CB), simulation program that helps analyze the uncertainties associated with Microsoft® Excel models by MC simulation, was proposed to calculate the transit time contaminants in porous media. The transport of contaminants in soil is represented by the one-dimensional (1D) form of the advection–dispersion equation (ADE). The computer program CONTRANS written in MATLAB language is foundation to simulate and estimate the thickness of landfill compacted clay liner. In order to simplify the task of determining the uncertainty of parameters by the MC simulation, the parameters corresponding to the expression Z2 taken from this program were used for the study. The tested parameters are: hydraulic gradient (HG), hydraulic conductivity (HC), porosity (POROS), linear thickness (TH) and diffusion coefficient (EDC). The principal output report provided by CB and presented in the study consists of the frequency chart, percentiles summary and statistics summary. Additional CB options provide a sensitivity analysis with tornado diagrams. The data that was used include available published figures as well as data concerning the Mittal Steel Poland (MSP) S.A. in Kraków, Poland. This paper discusses the results and show that the presented approach is applicable for any MSW landfill compacted clay liner thickness design. -- Highlights: ► Numerical simulation of waste in porous media is proposed. ► Statistic outputs based on correct assumptions about probability distribution are presented. ► The benefits of a MC simulation are examined. ► The uniform probability distribution is studied. ► I report a useful tool applied to determine the life of a modern MSW landfill.

  2. Stochastic approach to municipal solid waste landfill life based on the contaminant transit time modeling using the Monte Carlo (MC) simulation

    Energy Technology Data Exchange (ETDEWEB)

    Bieda, Boguslaw, E-mail: bbieda@zarz.agh.edu.pl

    2013-01-01

    The paper is concerned with application and benefits of MC simulation proposed for estimating the life of a modern municipal solid waste (MSW) landfill. The software Crystal Ball Registered-Sign (CB), simulation program that helps analyze the uncertainties associated with Microsoft Registered-Sign Excel models by MC simulation, was proposed to calculate the transit time contaminants in porous media. The transport of contaminants in soil is represented by the one-dimensional (1D) form of the advection-dispersion equation (ADE). The computer program CONTRANS written in MATLAB language is foundation to simulate and estimate the thickness of landfill compacted clay liner. In order to simplify the task of determining the uncertainty of parameters by the MC simulation, the parameters corresponding to the expression Z2 taken from this program were used for the study. The tested parameters are: hydraulic gradient (HG), hydraulic conductivity (HC), porosity (POROS), linear thickness (TH) and diffusion coefficient (EDC). The principal output report provided by CB and presented in the study consists of the frequency chart, percentiles summary and statistics summary. Additional CB options provide a sensitivity analysis with tornado diagrams. The data that was used include available published figures as well as data concerning the Mittal Steel Poland (MSP) S.A. in Krakow, Poland. This paper discusses the results and show that the presented approach is applicable for any MSW landfill compacted clay liner thickness design. -- Highlights: Black-Right-Pointing-Pointer Numerical simulation of waste in porous media is proposed. Black-Right-Pointing-Pointer Statistic outputs based on correct assumptions about probability distribution are presented. Black-Right-Pointing-Pointer The benefits of a MC simulation are examined. Black-Right-Pointing-Pointer The uniform probability distribution is studied. Black-Right-Pointing-Pointer I report a useful tool applied to determine the life of a

  3. A Comparative Study of McDonald’s Wedding Narratives with the Model of Anchoring

    Directory of Open Access Journals (Sweden)

    Mimi Huang

    2016-12-01

    Full Text Available Fast-food giant McDonald’s announced in 2010 that they would start hosting wedding ceremonies and receptions for couples who would like to get married in their restaurants in Hong Kong. This paper conducts a study comparing the differing representations of McDonald’s wedding services through a narrative analytical approach. Specifically, this paper examines relevant discourses surrounding the launch of the corporation’s wedding services from the British media (e.g. Daily Mail, the Independent as well as public discourses in Hong Kong (e.g. McDonald’s Hong Kong website, and CNN’s Hong Kong news.  It is found that these narratives have a significant degree of discrepancy in depicting McDonald’s wedding stories. These differences further raise the question of how differing narrative strategies are employed to conceptualise the brand’s emergent wedding narratives in a unique social-cultural environment.  In the discussion of McDonald’s wedding stories, the focus is placed on the cognitive and linguistic aspects of the discourse. An analytical model of “anchoring” will be proposed and applied to investigate the cooperation’s marketing strategies as well as the media’s reaction towards such promotions. It is argued that a narrative can promote or demote a brand’s identity and position through the process of anchoring. It is further argued that anchoring is an important cognitive-psychological strategy in conceptualization and meaning construction. Keywords: narrative inquiry, cognitive narratology, anchors, anchoring, meaning construction

  4. 75 FR 38017 - Airworthiness Directives; McDonnell Douglas Corporation Model DC-9-10 Series Airplanes, DC-9-30...

    Science.gov (United States)

    2010-07-01

    ... Airworthiness Directives; McDonnell Douglas Corporation Model DC- 9-10 Series Airplanes, DC-9-30 Series... previously to all known U.S. owners and operators of the McDonnell Douglas Corporation airplanes identified... INFORMATION: On July 15, 2009, we issued AD 2009-15-16, which applies to all McDonnell Douglas Model DC-9-10...

  5. McDONALD OBSERVATORY ARCHIVE OF OPTICAL LINEAR POLARIZATION MEASUREMENTS

    International Nuclear Information System (INIS)

    Wills, Beverley J.; Wills, D.; Breger, M.

    2011-01-01

    We present 990 previously unpublished optical linear polarization measurements of quasars, active galactic nuclei, and some stars observed for interstellar polarization. The observations, covering the period 1981-2000, were made with McDonald Observatory's 2.1 m Struve reflector and the Breger photopolarimeter.

  6. Carbohydrate- and protein-rich diets in McArdle disease: Effects on exercise capacity

    DEFF Research Database (Denmark)

    Andersen, S.T.; Vissing, J.

    2008-01-01

    metabolism during exercise, which questions the effect of protein in McArdle disease. METHODS: In a crossover, open design, we studied 7 patients with McArdle disease, who were randomised to follow either a carbohydrate- or protein-rich diet for three days before testing. Caloric intake on each diet...... was identical, and was adjusted to the subject's weight, age and sex. After each diet, exercise tolerance and maximal work capacity were tested on a bicycle ergometer, using a constant workload for 15 minutes followed by an incremental workload to exhaustion. RESULTS: During the constant workload, heart rate...... capacity and exercise tolerance to submaximal workloads by maintaining a diet high in carbohydrate instead of protein. The carbohydrate diet not only improves tolerance to every-day activities, but will likely also help to prevent exercise-induced episodes of muscle injury in McArdle disease Udgivelsesdato...

  7. MC21/CTF and VERA multiphysics solutions to VERA core physics benchmark progression problems 6 and 7

    Directory of Open Access Journals (Sweden)

    Daniel J. Kelly, III

    2017-09-01

    Full Text Available The continuous energy Monte Carlo neutron transport code, MC21, was coupled to the CTF subchannel thermal-hydraulics code using a combination of Consortium for Advanced Simulation of Light Water Reactors (CASL tools and in-house Python scripts. An MC21/CTF solution for VERA Core Physics Benchmark Progression Problem 6 demonstrated good agreement with MC21/COBRA-IE and VERA solutions. The MC21/CTF solution for VERA Core Physics Benchmark Progression Problem 7, Watts Bar Unit 1 at beginning of cycle hot full power equilibrium xenon conditions, is the first published coupled Monte Carlo neutronics/subchannel T-H solution for this problem. MC21/CTF predicted a critical boron concentration of 854.5 ppm, yielding a critical eigenvalue of 0.99994 ± 6.8E-6 (95% confidence interval. Excellent agreement with a VERA solution of Problem 7 was also demonstrated for integral and local power and temperature parameters.

  8. Novel applications of the x-ray tracing software package McXtrace

    DEFF Research Database (Denmark)

    Bergbäck Knudsen, Erik; Nielsen, Martin Meedom; Haldrup, Kristoffer

    2014-01-01

    We will present examples of applying the X-ray tracing software package McXtrace to different kinds of X-ray scattering experiments. In particular we will be focusing on time-resolved type experiments. Simulations of full scale experiments are particularly useful for this kind, especially when...... some of the issues encountered. Generally more than one or all of these effects are present at once. Simulations can in these cases be used to identify distinct footprints of such distortions and thus give the experimenter a means of deconvoluting them from the signal. We will present a study...... of this kind along with the newest developments of the McXtrace software package....

  9. Converting the Key Lake mill process for McArthur River ore

    Energy Technology Data Exchange (ETDEWEB)

    Rodgers, C. [McArthur River Operation, Cameco Corporation, Saskatoon, Saskatchewan (Canada)

    2000-07-01

    The Key Lake mill was commissioned in 1983 to process the two Key Lake ore deposits. With the depletion of these ore bodies in 1999, the plant was converted to mill the exceptionally rich McArthur River deposit located seventy eight kilometers northeast of the Key Lake mine site. This paper describes in detail the Key Lake milling process. The mill consists of a grinding circuit, a leach/counter current decantation circuit, a solvent extraction circuit, a yellowcake precipitation/calciner circuit, an ammonium sulphate crystallization circuit, and a waste treatment circuit. The paper also describes process changes to handle McArthur River ore, including the ore receiving station. (author)

  10. HSV-1 strain McKrae is more neuroinvasive than HSV-1 KOS after corneal or vaginal inoculation in mice.

    Science.gov (United States)

    Wang, Hong; Davido, David J; Morrison, Lynda A

    2013-05-01

    Strains of HSV-1 have been noted to vary in their pathogenesis. We compared the replication of strains KOS and McKrae in mice by two routes of infection, ocular and vaginal. Peripheral replication of KOS was similar (cornea) or attenuated over time (vagina) compared with McKrae; however, McKrae replicated in the nervous system to significantly higher levels than KOS after inoculation by either route. Host genetic background strongly influenced the capacity for virus entry into the nervous system from the vagina. KOS and McKrae replicated equivalently after intracranial inoculation, indicating that McKrae's pathogenic phenotype is linked to neuroinvasiveness rather than neurovirulence. Copyright © 2013 Elsevier B.V. All rights reserved.

  11. NOAA Ship McArthurII Underway Meteorological Data, Quality Controlled

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Ship McArthur II Underway Meteorological Data (delayed ~10 days for quality control) are from the Shipboard Automated Meteorological and Oceanographic System...

  12. Roles of piRNAs in microcystin-leucine-arginine (MC-LR) induced reproductive toxicity in testis on male offspring.

    Science.gov (United States)

    Zhang, Ling; Zhang, Hui; Zhang, Huan; Benson, Mikael; Han, Xiaodong; Li, Dongmei

    2017-07-01

    In the present study, we evaluated the toxic effects on the testis of the male offspring of MC-LR exposure during fetal and lactational periods. Pregnant females were distributed into two experimental groups: control group and MC-LR group which were exposed to 0 and 10 μg/L of MC-LR, respectively, through drinking water separately during fetal and lactational periods. At the age of 30 days after birth, the male offspring were euthanized. The body weight, testis index, and histomorphology change were observed and the global changes of piwi-interacting RNA (piRNA) expression were evaluated. The results revealed that MC-LR was found in the testis of male offspring, body weight and testis index decreased significantly, and testicular tissue structure was damaged in the MC-LR group. In addition, the exposure to MC-LR resulted in an altered piRNA expression profile and an increase of the cell apoptosis and a decrease of the cell proliferation in the testis of the male offspring. It was reasonable to speculate that the toxic effects on reproductive system of the male offspring in MC-LR group might be mediated by piRNAs through the regulation of the target genes. As far as we are aware, this is the first report showing that MC-LR could play a role in disorder of proliferative and cell apoptosis in the testis of the male offspring by the maternal transmission effect of toxicity. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Stephen McGurk | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Previously, he served as IDRC Regional Director in IDRC's South Asia and China Office in Delhi and in the Southeast and East Asia office in Singapore. McGurk has worked with the Ford Foundation in Beijing, where he was responsible for its economic security program in China. He has taught at the University of California ...

  14. Dr. David Brown poses with students at Ronald McNair Middle School

    Science.gov (United States)

    1999-01-01

    Dr. David Brown (right), a NASA astronaut, poses with students in the gymnasium of Ronald McNair Magnet School in Cocoa, Fla. From left, the students are Kristin Rexford, Danitra Anderson, Dominique Smith, Fallon Davis, and Qiana Taylor. Brown was at the school to attend a tribute to NASA astronaut Ronald McNair. The school had previously been renamed for the fallen astronaut who was one of a crew of seven, who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

  15. GPM GROUND VALIDATION KICT NEXRAD MC3E V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The GPM Ground Validaiton KICT NEXRAD MC3E dataset was collected from April 22, 2011 to June 6, 2011 for the Midlatitude Continental Convective Clouds Experiment...

  16. GPM GROUND VALIDATION CHILL RADAR MC3E V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The CHILL radar data for the Midlatitude Continental Convective Clouds Experiment (MC3E) held in Oklahoma were collected while the NASA ER-2 aircraft conducted a...

  17. Ukrainian National System of MC&A Training on Regular Basis at the George Kuzmych Training Center

    International Nuclear Information System (INIS)

    Kyryshchuk, V.; Gavrilyuk, V.; Drapey, S.; Romanova, O.; Levina, E.; Proskurin, D.; Gavrilyuk-Burakova, A.; Parkhomenko, V.; Van Dassen, L.; Delalic, Z.

    2015-01-01

    The George Kuzmych Training Center (GKTC) was created at the Kyiv Institute for Nuclear Research as a result of collaborative efforts between the United States and Ukraine in 1998. Later the European Commission (EC) and Sweden joined the USA supporting MC&A aspects of the GKTC activity. The GKTC was designated by the Ukrainian Government to provide the MPC&A training and methodological assistance to nuclear facilities and nuclear specialists. In order to increase the efficiency of State MC&A system an essential number of new regulations, norms and rules was developed demanding regular and more intensive MC&A experts training from the Regulatory Body of Ukraine and all nuclear facilities. For this purpose ten training courses were developed by the GKTC under the EC contract taking into account both specifics of Ukrainian nuclear facilities and expertise level of their personnel. Along with the NDA training laboratory created with the US DOE financial support and methodological assistance in 2003, a new surveillance and containment laboratory was created under the EC contract and with US DOE financial support as well. Moreover, under the EC contract the laboratory was equipped with the state-of-the-art and most advanced means of surveillance and containment strengthening even more the GKTC training opportunities. As a result, the MC&A experts from all nuclear facilities and Regulatory Body of Ukraine can regularly be trained practically on all MC&A issues. This paper briefly describes the practical efforts applied to improve Ukrainian MC&A systems both at the State and facility levels and real results on the way to develop the National System for MC&A regular training at the GKTC, problems encountered and their solution, comments, suggestions and recommendations for the future activity to promote and improve the nuclear security culture in Ukraine. (author)

  18. In-Vivo Measurement of Muscle Tension: Dynamic Properties of the MC Sensor during Isometric Muscle Contraction

    Directory of Open Access Journals (Sweden)

    Srđan Đorđević

    2014-09-01

    Full Text Available Skeletal muscle is the largest tissue structure in our body and plays an essential role for producing motion through integrated action with bones, tendons, ligaments and joints, for stabilizing body position, for generation of heat through cell respiration and for blood glucose disposal. A key function of skeletal muscle is force generation. Non-invasive and selective measurement of muscle contraction force in the field and in clinical settings has always been challenging. The aim of our work has been to develop a sensor that can overcome these difficulties and therefore enable measurement of muscle force during different contraction conditions. In this study, we tested the mechanical properties of a “Muscle Contraction” (MC sensor during isometric muscle contraction in different length/tension conditions. The MC sensor is attached so that it indents the skin overlying a muscle group and detects varying degrees of tension during muscular contraction. We compared MC sensor readings over the biceps brachii (BB muscle to dynamometric measurements of force of elbow flexion, together with recordings of surface EMG signal of BB during isometric contractions at 15° and 90° of elbow flexion. Statistical correlation between MC signal and force was very high at 15° (r = 0.976 and 90° (r = 0.966 across the complete time domain. Normalized SD or σN = σ/max(FMC was used as a measure of linearity of MC signal and elbow flexion force in dynamic conditions. The average was 8.24% for an elbow angle of 90° and 10.01% for an elbow of angle 15°, which indicates high linearity and good dynamic properties of MC sensor signal when compared to elbow flexion force. The next step of testing MC sensor potential will be to measure tension of muscle-tendon complex in conditions when length and tension change simultaneously during human motion.

  19. Tensor form factor for the D → π(K) transitions with Twisted Mass fermions.

    Science.gov (United States)

    Lubicz, Vittorio; Riggio, Lorenzo; Salerno, Giorgio; Simula, Silvano; Tarantino, Cecilia

    2018-03-01

    We present a preliminary lattice calculation of the D → π and D → K tensor form factors fT (q2) as a function of the squared 4-momentum transfer q2. ETMC recently computed the vector and scalar form factors f+(q2) and f0(q2) describing D → π(K)lv semileptonic decays analyzing the vector current and the scalar density. The study of the weak tensor current, which is directly related to the tensor form factor, completes the set of hadronic matrix element regulating the transition between these two pseudoscalar mesons within and beyond the Standard Model where a non-zero tensor coupling is possible. Our analysis is based on the gauge configurations produced by the European Twisted Mass Collaboration with Nf = 2 + 1 + 1 flavors of dynamical quarks. We simulated at three different values of the lattice spacing and with pion masses as small as 210 MeV and with the valence heavy quark in the mass range from ≃ 0.7 mc to ≃ 1.2mc. The matrix element of the tensor current are determined for a plethora of kinematical conditions in which parent and child mesons are either moving or at rest. As for the vector and scalar form factors, Lorentz symmetry breaking due to hypercubic effects is clearly observed in the data. We will present preliminary results on the removal of such hypercubic lattice effects.

  20. An Air-conditioned Global Warming. The Description of Settings in Ian McEwan’s Solar

    Directory of Open Access Journals (Sweden)

    Elisa Bolchi

    2016-12-01

    Full Text Available The three main settings of McEwan’s Solar, a novel described as “the first great global-warming novel” (Walsh 2010 are significant: from London, to the Artic Pole, up to the desert in New Mexico, these places are all described through the interior monologue of the anti-hero Michael Beard, a character allegorical of humanity’s greed for selfish over-consumption. As Beard moves in the real environment only through the non-places of supermodernity (Augé, the paper ana¬lyses the descriptions of settings to underline how McEwan uses them to write about climate- change in a new “novelistic” way (McEwan.