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Sample records for mer project successfully

  1. Successful project management

    Young, Trevor L

    2016-01-01

    Successful Project Management, 5th edition, is an essential guide for anyone who wants to improve the success rate of their projects. It will help managers to maintain a balance between the demands of the customer, the project, the team and the organization. Covering the more technical aspects of a project from start to completion it contains practised and tested techniques, covering project conception and start-up, how to manage stake holders, effective risk management, project planning and launch and execution. Also including a brand new glossary of key terms, it provides help with evaluating your project as well as practical checklists and templates to ensure success for any ambitious project manager. With over one million copies sold, the hugely popular Creating Success series covers a wide variety of topic, with the latest editions including new chapters such as Tough Conversations and Treating People Right. This indispensable business skills collection is suited to a variety of roles, from someone look...

  2. The Project of Success

    Kreiner, Kristian

    more complicated matter than meeting targets. While success may ultimately be justified in terms of a correspondence between aims and achievements, the understanding of both aspects is highly dependent on the project process. An example of a successful project that did not meet the original performance...... targets will serve to show that success is at matter of perspective as much as it is a matter of achievement. Other types of research, e.g. social psychology, have addressed the issue of success more explicitly. I draw on such literature to conceptualize project success anew and to reestablish...

  3. Dust Accumulation and Solar Panel Array Performance on the Mars Exploration Rover (MER) Project

    Turgay, Eren H.

    2004-01-01

    One of the most fundamental design considerations for any space vehicle is its power supply system. Many options exist, including batteries, fuel cells, nuclear reactors, radioisotopic thermal generators (RTGs), and solar panel arrays. Solar arrays have many advantages over other types of power generation. They are lightweight and relatively inexpensive, allowing more mass and funding to be allocated for other important devices, such as scientific instruments. For Mars applications, solar power is an excellent option, especially for long missions. One might think that dust storms would be a problem; however, while dust blocks some solar energy, it also scatters it, making it diffuse rather than beamed. Solar cells are still able to capture this diffuse energy and convert it into substantial electrical power. For these reasons, solar power was chosen to be used on the 1997 Mars Pathfinder mission. The success of this mission set a precedent, as NASA engineers have selected solar power as the energy system of choice for all future Mars missions, including the Mars Exploration Rover (MER) Project. Solar sells have their drawbacks, however. They are difficult to manufacture and are relatively fragile. In addition, solar cells are highly sensitive to different parts of the solar spectrum, and finding the correct balance is crucial to the success of space missions. Another drawback is that the power generated is not a constant with respect to time, but rather changes with the relative angle to the sun. On Mars, dust accumulation also becomes a factor. Over time, dust settles out of the atmosphere and onto solar panels. This dust blocks and shifts the frequency of the incoming light, degrading solar cell performance. My goal is to analyze solar panel telemetry data from the two MERs (Spirit and Opportunity) in an effort to accurately model the effect of dust accumulation on solar panels. This is no easy process due to the large number of factors involved. Changing solar

  4. Project Success in Agile Development Software Projects

    Farlik, John T.

    2016-01-01

    Project success has multiple definitions in the scholarly literature. Research has shown that some scholars and practitioners define project success as the completion of a project within schedule and within budget. Others consider a successful project as one in which the customer is satisfied with the product. This quantitative study was conducted…

  5. Project Success in IT Project Management

    Siddiqui, Farhan Ahmed

    2010-01-01

    The rate of failed and challenged Information Technology (IT) projects is too high according to the CHAOS Studies by the Standish Group and the literature on project management (Standish Group, 2008). The CHAOS Studies define project success as meeting the triple constraints of scope, time, and cost. The criteria for project success need to be agreed by all parties before the start of the project and constantly reviewed as the project progresses. Assessing critical success factors is another ...

  6. Analyzing MER Uplink Reports

    Savin, Stephen C.

    2005-01-01

    The MER project includes two rovers working simultaneously on opposite sides of Mars each receiving commands only once a day. Creating this uplink is critical, since a failed uplink means a lost day and a waste of money. Examining the process of creating this uplink, I tracked the use of the system developed for requesting observations as well as the development, from stage to stage, in forming an activity plan. I found the system for requesting observations was commonly misused, if used at all. There are half a dozen reports to document the creation of the uplink plan and often there are discrepancies among them. Despite this, the uplink process worked very well and MER has been one of the most successful missions for NASA in recent memory. Still it is clear there is room for improvement.

  7. Relationships and project marketing success

    Skaates, Maria Anne; Tikkanen, Henrikki; Lindblom, Jarno

    2002-01-01

    Project operations are a dominating mode of international business. Managing relationships and networks is crucial to project marketing success both at the level of the individual project and at the level of multiple projects. This article first defines key characteristics of project business, id...

  8. A successful integrated project.

    Zheng, P

    1994-10-01

    The experiences of the Juxian County Family Planning Committee of Shandong Province, China, were discussed in terms of the integration of family planning with income generation activities in rural areas. The integrated program was initiated in 1988 with pilot programs established by the Qiaoshan Family Planning Association to develop marketable skills in carpet weaving and grass braiding in Xiazhuang Town and Qiaoshan Township. The program gave priority of admission to women with only children and those who practiced family planning. 1400 women were recruited in these factories. Other income generation programs were developed for silkworm breeding and silk reeling, woolen embroidery, and printing. High ranking officials of the China Family Planning Association commended the work in income generation and family planning in Juxian County. This recognition spurred the second phase of development by the county family planning association: the establishment of village operated factories and mills for native products. By the end of 1991, there were 26 such projects in the county and per capita income to women increased by RMB 678 yuan. In the third stage of 1992, the number of association enterprises increased to 196 with recruitment of over 18,000 reproductive age women. The programs were initiated with collective funds from farmers and villages. The 170 projects in 1992 were developed with an investment of 9.6 million yuan, of which 2.26 million yuan was from individuals (23.5%). Emphasis was placed on self-reliance and recruitment of women with one child, women with 2 daughters and tubal ligations, and family planning motivators. The consequences of the integrated program were weakening traditional customs of marriage and childbearing, improvement in socioeconomic status of women, and effective service delivery of family planning and maternal and child health care services.

  9. Perspectives on projects, project success and team work

    Thompson, Karen

    2015-01-01

    This paper brings together perspectives on projects, project success and team work as a background to two graphical tools for considering project success and individual capabilities for working in a project team.

  10. Key performance indicators for successful simulation projects

    Jahangirian, M; Taylor, SJE; Young, T; Robinson, S

    2016-01-01

    There are many factors that may contribute to the successful delivery of a simulation project. To provide a structured approach to assessing the impact various factors have on project success, we propose a top-down framework whereby 15 Key Performance Indicators (KPI) are developed that represent the level of successfulness of simulation projects from various perspectives. They are linked to a set of Critical Success Factors (CSF) as reported in the simulation literature. A single measure cal...

  11. Project manager attributes influencing project success in the South ...

    success criteria for building projects in Ghana and concluded that the “current and ... qualifications, profession, leadership style and project team ... and expectations of project management competence between ... 1.d. Sense of teamwork ...

  12. Critical success factors in infrastructure projects

    Zakaria, Siti Fairus; Zin, Rosli Mohamad; Mohamad, Ismail; Balubaid, Saeed; Mydin, Shaik Hussein; Mohd Rahim, E. M. Roodienyanto

    2017-11-01

    Construction of infrastructure project is different from buildings. The main difference is term of project site where infrastructure project need to command a long stretch while building mostly confine to a limited area. As such factors that are critical to infrastructure project may not be that significant to building project and vice versa. Flood mitigation can be classified under infrastructure projects under which their developments are planned by the government with the specific objective to reduce or avoid the negative effects of flood to the environment and livelihood. One of the indicators in project success is delay. The impact of project delay in construction industry is significant that it decelerates the projects implementation, specifically the government projects. This study attempted to identify and compare the success factors between infrastructure and building projects, as such comparison rarely found in the current literature. A model of flood mitigation projects' success factors was developed by merging the experts' views and reports from the existing literature. The experts' views were obtained from the responses to open-ended questions on the required fundamentals to achieve successful completion of flood mitigation projects. An affinity analysis was applied to these responses to develop the model. The developed model was then compared to the established success factors found in building project, extracted from the previous studies to identify the similarities and differences between the two models. This study would assist the government and construction players to become more effective in constructing successful flood mitigation projects for the future practice in a flood-prone country like Malaysia.

  13. Critical success factors in information technology projects

    Ayesha

    2017-02-01

    Full Text Available The purpose of this study is to determine the critical success factors (CSF of IT projects in Pa-kistan. The identified factors cannot only be functional to exact type IT projects but also to all types of IT projects, their success directly affects the achievement of whole organization. The proposed study of this paper has determined 15 factors influencing the most on the success of IT projects through multiple regression analysis. The survey has disclosed that many CSFs were found related to IT projects but these 15 factors are also the backbone of IT projects. The re-search results obtained clearly indicated that the Leadership Qualities played a significant role in obtaining Top Management support in order to access to resources however, the Leadership Qualities did not play any role on the trained and capable Project Team Members. Besides, it is undoubtedly defined effective communication of the project was established to be influential on the conclusion and contributing factor towards the Success of IT projects in Pakistan. Top Man-agement Support as a whole was not found to play a key role in the IT Project Success.

  14. Critical success factors for renewable energy projects

    1995-01-01

    This project highlighted best practice in the planning and assessment of proposals with the aim of: encouraging more successful renewable energy projects and proposals; lowering financial and other barriers; and stimulating a climate for success. Based on the analysis of a number of case studies, data was collected through a series of extensive interviews to identify why certain schemes were considered successful, what might have been done differently and which factors were considered important when entering a market. The Critical Success Factors can be broken down into five groups: Universal CSFs; CSFs for funding bodies; CSFs for managing agencies; CSFs for niche markets; CSFs for individual technologies. (author)

  15. Project Management Yinyang: Coupling project success and client satisfaction

    Greg Stewart Usher

    2017-06-01

    Full Text Available Our research applies paradox theory to a project management construct to help project management researchers and practitioners understand the tensions that can exist between project success and client satisfaction. Our research highlights that although project success and client satisfaction are both present within a project management construct, they also belong to different functional systems. Project success and client satisfaction have different systemic-discourses and use different language games to convey information. These distinctions can create latent and sometimes salient tensions within the project management construct that project managers must understand, embrace, and work with. We have used a Grounded Theory (GT methodology to explore the lived experience of project managers, and from this have identified a phenomenon which we have termed project management yinyang. Project management yinyang is the state that exists when both project success and Client satisfaction are tightly coupled within the project management construct. Project management yinyang highlights that these two phenomena cannot be viewed as separate elements because the ‘seed’ of each exists within the other. And to truly achieve one, you must also achieve the other. Our findings indicate that in order to create project management yinyang the project manager must embrace a paradoxical yet holistic philosophy. They must understand the complementarity, interdependency, and structural coupling that exists between the positivist and interpretivist paradigms within the project management construct. They must understand how satisfaction (Yin and success (Yang are created through focus. Furthermore, they must understand how project management yinyang is separate from, but borne from, the convergence of the other two elements.

  16. Determinants of construction project success in India

    Jha, Kumar Neeraj

    2013-01-01

    This study presents exploratory work and seeks to identify and evaluate the success and failure factors that could form a guideline for further study and to some extent help professionals to understand some critical aspects that impact project performance concerning construction in India. A total of 55 attributes affecting the performance of construction projects are analysed in terms of their level of influence on four key performance criteria – schedule, cost, quality, and no disputes – using a two-stage questionnaire survey. These attributes are then further analysed, interpreted and evaluated.   Based on the critical success factors obtained from the study, a neural network model-based predictive model for project performance has been developed. The performance prediction models have been derived for all four project performance criteria. Further, a hypothesis that ‘project success’ is influenced by ‘success traits’ has also been formulated. The hypothesized positive inter-relationships betwe...

  17. Leadership and Project Success in Development Sector

    Saghir Ahmed

    2017-10-01

    Full Text Available Aim/purpose - The study aims to investigate the relationship among the leadership, operational efficiency and project success in general and the impact of transformational leadership and operational efficiency on project success in particular. Design/methodology/approach - Mean comparison from descriptive statistics and multiple linear regression from inferential statistics was used to determine the association between variables and further impact of the transformational leadership and operational efficiency on project success in the development sector. The paper presents the results of a survey conducted among 200 employees from the top, middle & lower management levels of various national & international development organizations working in Pakistan like Microfinance Banks and other Rural Support Programs. Statistical Package for Social Sciences (SPSS was used to process data. Findings - The result shows positive association among transformational leadership, operational efficiency and project success. In addition, it was found that transformational leadership and operational efficiency have a positive and statistically significant impact on the project success. It is concluded that both transformational leadership and operational efficiency are vital to achieving the optimum level of success in any project, especially in the development sector. Research implications/limitations - The integral limitation of the study was the respondents because most of the development organizations have their operations in rural areas where access was difficult because of limited time and resources. In addition, such organizations are always reluctant to provide survey feedback. Originality/value/contribution - The paper contribution is in the theoretical and practical knowledge of the project success factors in the development sector which is still a somehow unexplored area. Regulators of the development sector may be benefited from this study.

  18. Influence of organizational and project cultures on project success

    Berdykulova G. M.

    2017-10-01

    Full Text Available the article is dedicated to studying the influence of organizational and project cultures on effective project management of the company by knowledge systematization and the comparative analysis of world companies’ practice that allowed to reveal the main factors and criteria of projects success and negative influence of organizational culture on the project; key aspects of corporate culture and cultural integration under the conditions of globalization.

  19. Structuring lighting retrofit projects for success

    Fetters, J.L.

    1993-01-01

    Several trends are converging to create a substantial market for lighting retrofits in these uncertain economic times. Low interest rates are making investments in buildings more attractive than alternative financial investments such as CD's. With activity in the new construction market at an all time low, savvy contractors are turning to the retrofit market - restoring, renovating and upgrading existing buildings. Heightened environmental concerns are fueling lighting incentive programs from the electric utilities and the EPA. Improvements in lighting technology are arriving in the marketplace at an accelerated rate. Building occupants are demanding higher quality workplaces and managers are seeking higher levels of productivity. Replacing older lighting equipment can substantially improve lighting efficiency, decrease energy and maintenance costs and, at the same time, improve the workplace by increasing lighting quality Lighting retrofit projects have a demonstrated track record, reducing lighting costs on the order of 50%. This experience can be applied to help structure retrofit projects. But, in order to reap all the benefits available from a retrofit project, it must be structured for success. The retrofit option introduces a unique series of issues for building owners, managers and engineers. The best way to prevent these issues from undermining the success of retrofit projects is to anticipate and completely plan for them. Successful retrofit projects run smoothER and stay within budgetary constraints. Three important considerations will guide the successful project: (1) Start comprehensive planning early, (2) Investigate existing conditions, and (3) Be sensitive to owner/occupants needs keep building operational

  20. Mathematical Modeling Projects: Success for All Students

    Shelton, Therese

    2018-01-01

    Mathematical modeling allows flexibility for a project-based experience. We share details of our regular capstone course, successful for virtually 100% of our math majors for almost two decades. Our research-like approach in this course accommodates a variety of student backgrounds and interests, and has produced some award-winning student…

  1. European projects: a new wave of success

    2011-01-01

    Since the beginning of this year, no fewer than six new EU projects at CERN have been launched. These are just a third of the projects selected by the European Commission for funding during the course of 2010, bringing in some 23 M€ over a period of two to five years. This makes last year our most successful yet in securing EU support, and places CERN among the top 50 out of more than 10,000 participants in the EU’s seventh Framework Programme.   The success rate of our proposals has been very good ever since the beginning of FP7 in 2007, particularly for projects coordinated by CERN. There has been a clear evolution of CERN’s involvement in EU projects over the last 10 years. In the early days, we tended to target the Marie Curie actions and the e-Infrastructures Programme. The former help us to fulfil our mission to train young people, while the latter supported the development of the European Grid, mainly through the EGEE projects. Later, the Organization became a...

  2. Leadership success within disaster restoration projects.

    Rapp, Randy R; Baroudi, Bassam

    2014-01-01

    Successful project managers draw their performance from essential leadership traits, as guided by their core values.Within disaster recovery, contractors who mitigate, repair, and reconstruct the built environment are often faced with challenges exceeding the norm. The effective leader is commonly expected to consider stakeholder motivations within distressing situations as well as other external and environmental factors when seeking to lead the project team to successful outcomes. This research is most concerned with leadership within the context of disaster restoration of the built environment. Its stimulus comes from the Restoration Industry Association (RIA)'s efforts to highlight leadership traits and core values for its Certified Restorer Body of Knowledge but would be of value to others associated with disaster recovery operations. Among organizations whose membership includes thousands of practitioners who restore and reconstruct the built environment after disasters, the RIA is the only one yet to formally and substantially research which core values and leader traits are deemed critical for the success of efforts to manage the means and methods applied on recovery job sites. Forty-six seasoned disaster restoration industry project professionals voluntarily responded to a survey questionnaire that sought their opinions about the traits and core values that they consider most important for successful disaster restoration project leadership. The most important leader traits were effective communication, professional competence, and leadership by example. The most important restoration industry values were integrity, compassion, and trustworthiness. The recognized imperative of compassion was unexpected in light of stereotypes often associated with construction-related contractors. This and other findings permit disaster response and recovery stakeholders to better understand qualities they should wish to see in leaders of contractor organizations, which

  3. Successful Control of Major Project Budgets

    Steen Lichtenberg

    2016-07-01

    Full Text Available This paper differs from scientific papers describing current research. In line with the theme of this special issue, it challenges conventional risk management practice against the background of former research results successfully finished decades ago. It is well-known that conventional practice frequently results in budget overruns of large projects. International reviews document that. Severe delays of schedules are also well-known. This paper describes successful research results from almost three decades ago, which successfully challenges this severe problem and has led to new practices. The research involved is an unusual mix: Scandinavian researchers from psychology, statistical theory and engineering economy. The resulting procedure has been widely used since around 1990 and challenges conventional procedures. The procedure is documented to be able to yield statistically correct prognoses, when the “rules of the game” have been correctly followed. After a short summary of the basic situation, this paper summarizes the research, followed by some resulting experiences, focusing on two recent studies each of 40 infrastructures and other major projects. In both sets, the actual final cost largely equaled the expected project cost. This result is a marked change from international past and present experience. Finally, the need for further research and progress is discussed.

  4. Vague project start makes project success of outsourced software development projects uncertain

    Savolainen, Paula

    2010-01-01

    peer-reviewed A definition of a project success includes at least three criteria: 1) meeting planning goals, 2) customer benefits, and 3) supplier benefits. This study aims to point out the importance of the definition of the project start, the project start date, and what work should be included in the project effort in order to ensure the supplier's benefits. The ambiguity of the project start risks the profitability of the project and therefore makes project success at least from suppli...

  5. Examination of the relationship between project management critical success factors and project success of oil and gas drilling projects

    Alagba, Tonye J.

    Oil and gas drilling projects are the primary means by which oil companies recover large volumes of commercially available hydrocarbons from deep reservoirs. These types of projects are complex in nature, involving management of multiple stakeholder interfaces, multidisciplinary personnel, complex contractor relationships, and turbulent environmental and market conditions, necessitating the application of proven project management best practices and critical success factors (CSFs) to achieve success. Although there is some practitioner oriented literature on project management CSFs for drilling projects, none of these is based on empirical evidence, from research. In addition, the literature has reported alarming rates of oil and gas drilling project failure, which is attributable not to technical factors, but to failure of project management. The aim of this quantitative correlational study therefore, was to discover an empirically verified list of project management CSFs, which consistent application leads to successful implementation of oil and gas drilling projects. The study collected survey data online, from a random sample of 127 oil and gas drilling personnel who were members of LinkedIn's online community "Drilling Supervisors, Managers, and Engineers". The results of the study indicated that 10 project management factors are individually related to project success of oil and gas drilling projects. These 10 CSFs are namely; Project mission, Top management support, Project schedule/plan, Client consultation, Personnel, Technical tasks, Client acceptance, Monitoring and feedback, Communication, and Troubleshooting. In addition, the study found that the relationships between the 10 CSFs and drilling project success is unaffected by participant and project demographics---role of project personnel, and project location. The significance of these findings are both practical, and theoretical. Practically, application of an empirically verified CSFs list to oil

  6. The Impact of Project Manager on Project Success – The Case of ICT Sector

    Blaskovics, Bálint

    2016-01-01

    The project management literature on project success is rich. Numerous papers focus on the evolution of the understanding of project success, identification of success criteria and critical success factors. Critical success factors increase the potential for achieving project success, while project success can be evaluated with the help of success criteria. Although the interrelationships between critical success factors and success criteria are rarely analyzed, yet there is a strong demand f...

  7. Wisdom for Building the Project Manager/Project Sponsor Relationship: Partnership for Project Success

    Patton, Nanette; Shechet, Allan

    2007-01-01

    .... This article discusses conventional roles and responsibilities of the project sponsor and then discusses strategies a project manager can employ to define boundaries to reduce role confusion and promote partnership to facilitate project success.

  8. Success Factors in Wind Power Projects

    Cabal, H.; Varela, M.; Lago, C.; Saez, R. M.

    2002-01-01

    The Spanish wind energy market has experienced an average annual increase over 60% in recent years. With more than 4.1 GW of power at the end of 2002, this market has became the second in Europe and the third in the world. With the objective of obtaining the origin of this success, an analysis of technical and economic features of selected wind projects has been undertaken to draw the outstanding factors that any new independent promoter/developer should take into account within this market. (Author) 16 refs

  9. Quantum theory of successive projective measurements

    Johansen, Lars M.

    2007-01-01

    We show that a quantum state may be represented as the sum of a joint probability and a complex quantum modification term. The joint probability and the modification term can both be observed in successive projective measurements. The complex modification term is a measure of measurement disturbance. A selective phase rotation is needed to obtain the imaginary part. This leads to a complex quasiprobability: The Kirkwood distribution. We show that the Kirkwood distribution contains full information about the state if the two observables are maximal and complementary. The Kirkwood distribution gives another picture of state reduction. In a nonselective measurement, the modification term vanishes. A selective measurement leads to a quantum state as a non-negative conditional probability. We demonstrate the special significance of the Schwinger basis

  10. MER SPICE Interface

    Sayfi, Elias

    2004-01-01

    MER SPICE Interface is a software module for use in conjunction with the Mars Exploration Rover (MER) mission and the SPICE software system of the Navigation and Ancillary Information Facility (NAIF) at NASA's Jet Propulsion Laboratory. (SPICE is used to acquire, record, and disseminate engineering, navigational, and other ancillary data describing circumstances under which data were acquired by spaceborne scientific instruments.) Given a Spacecraft Clock value, MER SPICE Interface extracts MER-specific data from SPICE kernels (essentially, raw data files) and calculates values for Planet Day Number, Local Solar Longitude, Local Solar Elevation, Local Solar Azimuth, and Local Solar Time (UTC). MER SPICE Interface was adapted from a subroutine, denoted m98SpiceIF written by Payam Zamani, that was intended to calculate SPICE values for the Mars Polar Lander. The main difference between MER SPICE Interface and m98SpiceIf is that MER SPICE Interface does not explicitly call CHRONOS, a time-conversion program that is part of a library of utility subprograms within SPICE. Instead, MER SPICE Interface mimics some portions of the CHRONOS code, the advantage being that it executes much faster and can efficiently be called from a pipeline of events in a parallel processing environment.

  11. A Correlational Study Assessing the Relationships among Information Technology Project Complexity, Project Complication, and Project Success

    Williamson, David J.

    2011-01-01

    The specific problem addressed in this study was the low success rate of information technology (IT) projects in the U.S. Due to the abstract nature and inherent complexity of software development, IT projects are among the most complex projects encountered. Most existing schools of project management theory are based on the rational systems…

  12. Critical success factors influencing project success in the ...

    team members experience job satisfaction and are, therefore, motivated to be ... who are principal agents that were the interface between the client and the contractor. .... define roles and responsibilities of project team members. According.

  13. The International Successful School Principalship Project: Success Sustained?

    Moos, Lejf; Johansson, Olof

    2009-01-01

    Purpose: The purpose of this paper is to synthesize the findings of the follow-up studies of successful school principals in six countries: Australia, Denmark, England, Norway, Sweden, and the USA. Design/methodology/approach: Data were categorized according to stakeholder expectations, the concept and practice of leadership, and the…

  14. Determining Success Criteria and Success Factors for International Construction Projects for Malaysian Contractors

    Ali Mohammed Alashwal

    2017-06-01

    Full Text Available The success of international construction projects is fraught with various challenges such as competitiveness, lack of resources, versatile global economy, and specific conditions in the host country. Malaysian contractors have been venturing into global construction market since early 1980s. However, their venturing was not successful all the time. The number of international projects awarded to Malaysian contractors has reduced drastically during the past decade. Taking advantage of this experience, this paper aims to identify the success criteria and success factors of international construction projects. The data was collected from 120 respondents using a questionnaire survey and analysed using principal component analysis and regression analysis. The results revealed three principal criteria of project success namely, Management Success, Functional Success, and Organisation Success. The main components of success factors include Team Power and Skills, Resource Availability, External Environment, Organisation Capability, Project Support, and Project Organisation. Further analysis emphasized the importance of strong financing capacity of contractors, project social environment, and competence of the project manager in achieving project success. The results of this paper can serve as a guideline for contractors and project managers to achieve success in this context. Future studies may provide in-depth analysis of success criteria and success factors specific for construction project type and host-country location.

  15. Criteria for Developing a Successful Privatization Project

    1989-05-01

    conceptualization and planning are required when pursuing privatization projects. In fact, privatization project proponents need to know how to...selection of projects for analysis, methods of acquiring information about these projects, and the analysis framwork . Chapter IV includes the analysis. A...performed an analysis to determine cormion conceptual and creative approaches and lessons learned. This analysis was then used to develop criteria for

  16. Correlational Study of Risk Management and Information Technology Project Success

    Gillespie, Seth J.

    2014-01-01

    Many IT projects fail despite the best efforts to keep these projects within budget, schedule, and scope. Few studies have looked at the effect of project risk management tools and techniques on project success. The primary focus of this study was to examine the extent to which utilization of project risk management processes influence project…

  17. MERS and SARS

    ... primary antibody and Goat anti-Rabbit 10 nm gold particles. Middle East Respiratory Syndrome (MERS-CoV) is ... standard mice or hamsters, scientists at NIAID Rocky Mountain Laboratories (RML) took the unusual step of moving ...

  18. Impact of Stakeholder Psychological Empowerment on Project Success

    Herry Pintardi Chandra

    2011-05-01

    Full Text Available The relationship between psychological empowerment of stakeholders and project success is an important thing that must be known by project manager. This research developed and tested the model to predict how well the impact of stakeholder psychological empowerment on project success. Stakeholder psychological empowerment was defined to have five indicator variables covering intrinsic motivation, opportunity to perform, ability to perform, task behaviors, and contextual behaviors. Meanwhile, project success can be measured by cost performance, time performance, quality performance, profitability, and customer satisfaction. In this study, it was hypothesized that stakeholder psychological empowerment influenced project success. Based on the data obtained from a questionnaire survey carried out to 204 respondents, structural equation modeling (SEM was used for predicting the performance of project success. It was found that stakeholder psychological empowerment influenced project success, especially on the ability to perform of stakeholders.

  19. IT project management 30 steps to success

    Doraiswamy, Premanand

    2011-01-01

    This pocket guide is designed to help IT project managers to succeed, and is based on the author's years of experience in IT project management. The guide's step-by-step approach will enable those new to IT project management, or intending to make a career in this field, to master the essential skills. For seasoned professionals, the pocket guide offers an invaluable concise reference guide.

  20. Risk managements' communicative effects influencing IT project success

    de Bakker, Karel; Boonstra, Albert; Wortmann, Hans

    The central question of this research is if, and how, risk management contributes to the success of IS/IT projects. Risk management is used regularly in IT projects, despite indications in literature that risk management only occasionally contributes to IT project success. Drawing on Habermas we

  1. Effects of Risk Management Practices on IT Project Success

    Pimchangthong Daranee

    2017-03-01

    Full Text Available Successful management of an information technology (IT project is the most desirable for all organisations and stakeholders. Many researchers elaborated that risk management is a key part of project management for any project size. Risk management is so critical because it provides project managers with a forward-looking view of both threats and opportunities to improve the project success. The objectives of this research are to explore organisational factors affecting IT project success and risk management practices influencing IT project success. Risk management practices include risk identification, risk analysis, risk response planning, and risk monitoring and control. The IT project success is measured by process performance and product performance. Data are collected from 200 project managers, IT managers, and IT analysts in IT firms through questionnaires and analysed using Independent Sample t-test, One-way ANOVA, and Multiple Linear Regression at the statistical significance level of 0.05. The results show that the differences in organisational types affect IT project success in all aspects, while the differences on organisational sizes affect IT project success in the aspect of product performance and total aspects. Risk identification and risk response planning influence the process performance and the total aspects of IT project success. Risk identification has the highest positive influence on product performance, followed closely by risk response, while risk analysis negatively influences product performance.

  2. A Project Manager's Personal Attributes as Predictors for Success

    Valencia, Vhance V

    2007-01-01

    ...) possess that lead them to project management success. Numerous attributes are identified in the literature through a variety of methods, but very few studies relate specific qualities to success...

  3. Project management. A discipline which contributes to project success

    Hoch, G.

    2008-01-01

    The presentation covers the following topics: description of the Project - a contract was signed between KNPP and European Consortium Kozloduy (ECK) consisting of Framatome ANP GmbH as Leader (63%), Framatome ANP S.A.S. (17%), Atomenergoexport (20%) ; Project management in the modernization of NPP Kozloduy units 5 and 6; Project management process within AREVA NP GmbH; current status

  4. Successes and Experiences of the WIPP Project

    Chu, Margaret S.Y.; Weart, Wendell D.

    2000-01-01

    In May 1998, the US Environmental Agency (EPA) certified the US Department of Energy's (DOE) Waste Isolation Pilot Plant (WIPP) as being in compliance with all of the applicable regulations governing the permanent disposal of spent nuclear fuel, high-level waste, and transuranic radioactive waste. The WIPP, a transuranic waste repository, is the first deep geologic repository in the US to have successfully demonstrated regulatory compliance with long-term radioactive waste disposal regulations and be certified to receive wastes. Many lessons were learned throughout the 25-year history of the WIPP--from site selection to the ultimate successful certification. The experiences and lessons learned from the WIPP may be of general interest to other repository programs in the world. The lessons learned include all facets of a repository program: programmatic, managerial, regulatory, technical, and social. This paper addresses critical issues that arose during the 25 years of WIPP history and how they influenced the program

  5. Scintilla European project, the successful research results

    Sannie, G.; Kondrasov, V.; Corre, G.; Boudergui, K.; Perot, B.; Carasco, C.; Montemont, G. [Commissariat a l' energie atomique et aux energies alternatives, Saclay, Cadarache, Grenoble (France); Peerani, P.; Carrapico, C.; Tomanin, A.; Rosas, F.; Caviglia, M.; Eklund, G.; Tagziria, H. [European Commission, Joint Research Centre, ITU, Nuclear Security Unit, Ispra (Italy); Friedrich, H.; Chmel, S. [Fraunhofer-Institut fuer Naturwissenschaftlich - Technische Trendanalysen - INT, Euskirchen (Germany); De Vita, R.; Manchini, E.; Pavan, M. [Istituto Nazionale di Fisica Nucleare, Sezione di Genova, Genova (Italy); Grattarola, M.; Botta, E. [Ansaldo Nucleare S.P.A, Genova (Italy); Kovacs, A.; Lakosi, L. [Hungarian Academy of Sciences, Centre for Energy Research, Budapest (Hungary); Baumhauer, C.; Deheuninck, T.; Haddad, E. [ARTTIC, Paris (France); Petrossian, G.; Ferragut, A. [SAPHYMO, Massy (France); Dermody, G.; Crossingham, G. [Symetrica Security Ltd, Southampton (United Kingdom)

    2015-07-01

    The Scintilla FP7 project is ended in December 2014, the fruitful results of 3 years development and tests will be presented. SCINTILLA offers the capacity to finding a reliable alternative to Helium-3 based detection systems since the gas which is predominantly used in nuclear safeguards and security applications has now become very expensive, rare and nearly unavailable. SCINTILLA benchmarks results are based on international standards. Radiation Portal tests were carried out at the Joint Research Centre (JRC) in Ispra (Italy). The scintilla project addresses few mains issues. The first is to develop neutron detectors for Radiation Portal Monitor (RPM) and the second is the need of new wearable integrated solutions for Spectrometric Personal Radiation Monitor (SPRM). The partners which provide technical systems of the scintilla project are INFN-ANSALDO, CEA, SYMETRICA and SAPHYMO. For RPM, the objective is to find reliable alternatives to Helium-3 historical neutron detector and provide technical solutions which cope with tests for reliable mobile and cost effective. For Spectrometric Personal Radiation Monitor (SPRM), SCINTILLA is innovating in technology areas that offer complementary capabilities for detecting and identifying gamma, Two CZT (Cadmium Zinc Telluride) addressing contexts of used by first responder technologies, one is a wearable detector and the second is a gamma camera complemented by advanced image processing technologies. (authors)

  6. Agile project management managing for success

    Crowder, James A

    2015-01-01

    Management and enables them to deal with the demands and complexities of modern, agile systems/software/hardware development teams. The book examines the project/program manager beyond the concepts of leadership and aims to connect to employees' sense of identity. The text examines human psychological concepts such as "locus of control," which will help the manager understand their team members' view and how best to manage their "world" contributions. The authors cover new management tools and philosophies for agile systems/software/hardware development teams, with a specific focus on how this

  7. Project Neil Bone: a great success!

    Miles, R.

    2010-08-01

    Last October, the ARPS initiated a new observing project to make photometric observations of asteroids which reach a phase angle of 0.2° or less at opposition. The stimulus for this followed the naming last year of asteroid (7102) in honour of Neil Bone, our former Meteor Section Director, who sadly died last year. It turned out that (7102) would reach opposition on January 18 this year at an unusually low phase angle - just 0.03°. This is so small an angle that if you were standing on the asteroid on this date, you would be able to see the Earth transiting across the face of the Sun! The probability that (7102) would attain such a low phase angle is about once in several hundred years. So our project was set up with a view to observing its namesake along with a selection of thirteen other asteroids, which also happened to pass through very low phase angle at their opposition during the period 2009 October-2010 March.

  8. Middle East Respiratory Syndrome (MERS)

    Middle East Respiratory Syndrome Coronavirus; MERS-CoV; Novel coronavirus; nCoV ... for Disease Control and Prevention website. Middle East Respiratory Syndrome (MERS): Frequently asked questions and answers. www. ...

  9. Construction Project Success ranking through the Data Envelopment Analysis

    Mazyar Zahedi-Seresht

    2014-09-01

    Full Text Available The purpose of this paper is to rank construction projects' success in a post delivery phase. To attain this objective, a data envelopment analysis (DEA approach is used. The model's output is a project success index which is calculated based on five project success criteria. These criteria which are determined by a two-round Delphi questionnaire survey are time performance, cost performance, quality, HSE, and customer satisfaction. The input factors which have effects on the output measures are Organizational Sponsorship, Project Manager Competency, Customer Organization, Project Operational Environment and Organizational Experience. The tool adopted to determine these factors is questionnaire. This model is applied for 9 projects with different importance of output and input factors and the reasonable result is achieved for ranking these projects.

  10. Project description and crowdfunding success: an exploratory study.

    Zhou, Mi Jamie; Lu, Baozhou; Fan, Weiguo Patrick; Wang, G Alan

    2018-01-01

    Existing research on antecedent of funding success mainly focuses on basic project properties such as funding goal, duration, and project category. In this study, we view the process by which project owners raise funds from backers as a persuasion process through project descriptions. Guided by the unimodel theory of persuasion, this study identifies three exemplary antecedents (length, readability, and tone) from the content of project descriptions and two antecedents (past experience and past expertise) from the trustworthy cue of project descriptions. We then investigate their impacts on funding success. Using data collected from Kickstarter, a popular crowdfunding platform, we find that these antecedents are significantly associated with funding success. Empirical results show that the proposed model that incorporated these antecedents can achieve an accuracy of 73 % (70 % in F-measure). The result represents an improvement of roughly 14 percentage points over the baseline model based on informed guessing and 4 percentage points improvement over the mainstream model based on basic project properties (or 44 % improvement of mainstream's performance over informed guessing). The proposed model also has superior true positive and true negative rates. We also investigate the timeliness of project data and find that old project data is gradually becoming less relevant and losing predictive power to newly created projects. Overall, this study provides evidence that antecedents identified from project descriptions have incremental predictive power and can help project owners evaluate and improve the likelihood of funding success.

  11. Successful healthcare programs and projects: organization portfolio management essentials.

    Pickens, Scott; Solak, Jamie

    2005-01-01

    Many healthcare organization projects take more time and resources than planned and fail to deliver desired business outcomes. Healthcare IT is a major component of many projects and often undeservedly receives the blame for failure. Poor results are often not a result of faulty healthcare IT or poor project management or poor project execution alone. Many projects fail because of poor portfolio management--poor planning and management of the portfolio of initiatives designed to meet an organization's strategic goals. Because resources are limited, portfolio management enables organizations to more strategically allocate and manage their resources so care delivery, service delivery, and initiatives that advance organizations toward their strategic goals, including healthcare IT initiatives, can be accomplished at the levels of quality and service desired by an organization. Proper portfolio management is the essential foundation for program and project success and supports overall organization success. Without portfolio management, even programs and projects that execute flawlessly may not meet desired objectives. This article discusses the essential requirements for porfolio management. These include opportunity identification, return on investment (ROI) forecast, project prioritization, capacity planning (inclusive of human, financial, capital, and facilities resources), work scheduling, program and project management and execution, and project performance and value assessment. Portfolio management is essential to successful healthcare project execution. Theories are drawn from the Organizational Project Management Maturity Model (OPM3) work of the Project Management Institute and other leading strategy, planning, and organization change management research institutes.

  12. Sustainability: An Ethical Approach Towards Project Business Success

    G. S. Dangayach

    2011-01-01

    For any country the project management has been a vital part for its development. The highly competitive business world has created tremendous pressure on the project managers to achieve success. The pressure is derived from survival and profit building in business organizations which compels the project managers to pursue unethical practices. As a result unethical activities in business projects can be found easily where situations or issues arise due to dubious business...

  13. Understanding Megaproject Success beyond the Project Close-Out Stage

    Johan Fahri

    2015-08-01

    Full Text Available Project success has always been an important topic in the project management literature. One of the main discussions is concerned with how a project’s success is evaluated and what factors lead to achieving this success. Traditionally project success has been measured at the point where the project outputs are handed over, after the close out phase. Recently, questions have been raised in the literature as to whether we should be evaluating project success beyond the close out phase, to better account for organizational and societal outcomes.  However, not much has been published about how the long term impacts and outcomes are measured. This is of particular concern in megaprojects as they often attract a high level of public attention and political interest, and have both direct and indirect impacts on the community, environment, and national budgets. In this paper the authors review success factors and criteria that are applicable to projects in general and megaprojects in particular. They identify the significance of evaluating outcomes and impact and propose an ex-post project evaluation (EPPE framework for megaprojects.

  14. Critical Success Factors in Construction Projects (Governmental Projects as a Case Study)

    Hatem Khaleefah Al-Ageeli; Abdul Salam J. Ali Alzobaee

    2016-01-01

    The importance of the construction sector and its Great role in the provision of services and infrastructure, reduce poverty, improve living conditions and improve the economic situation in the country, impose attention to the way in which the projects implemented for its improvement and to get successful projects. The objective of this research was to determine the criteria for success as well as critical success and failure factors that have a significant impact on project success. A select...

  15. Determining critical success factor of it project management and its ...

    Determining critical success factor of it project management and its influence towards the ... Journal of Fundamental and Applied Sciences ... respondents who have background in IT management in both public and private sector to gain ...

  16. Engineering MerR for Sequestration and MerA for Reduction of Toxic Metals and Radionuclides

    Summers, Anne O.

    2008-01-01

    The objectives of this project were (1) to alter a metalloregulatory protein (MerR) so that it would bind other toxic metals or radionuclides with similar affinity so that the engineered protein itself and/or bacteria expressing it could be deployed in the environment to specifically sequester such metals and (2) to alter the mercuric reductase, MerA, to reduce radionuclides and render them less mobile. Both projects had a basic science component. In the first case, such information about MerR illuminates how proteins discriminate very similar metals/elements. In the second case, information about MerA reveals the criteria for transmission of reducing equivalents from NADPH to redox-active metals. The work involved genetic engineering of all or parts of both proteins and examination of their resultant properties both in vivo and in vitro, the latter with biochemical and biophysical tools including equilibrium and non-equilibrium dialysis, XAFS, NMR, x-ray crystallography, and titration calorimetry. We defined the basis for metal specificity in MerR, devised a bacterial strain that sequesters Hg while growing, characterized gold reduction by MerA and the role of the metallochaperone domain of MerA, and determined the 3-D structure of MerB, the organomercurial lyase.

  17. Traditional Project Management and the Visual Workplace Environment to Improve Project Success

    Fichera, Christopher E.

    2016-01-01

    A majority of large IT projects fail to meet scheduled deadlines, are over budget and do not satisfy the end user. Many projects fail in spite of utilizing traditional project management techniques. Research of project management has not identified the use of a visual workspace as a feature affecting or influencing the success of a project during…

  18. What drives continuous improvement project success in healthcare?

    Stelson, Paul; Hille, Joshua; Eseonu, Chinweike; Doolen, Toni

    2017-02-13

    Purpose The purpose of this paper is to present findings from a study of factors that affect continuous improvement (CI) project success in hospitals. Design/methodology/approach Quantitative regression analysis was performed on Likert scale survey responses. Qualitative thematic analysis was performed on open-ended survey responses and written reports on CI projects. Findings The paper identifies managerial and employee factors that affect project success. These factors include managerial support, communication, and affective commitment. Affective commitment is the extent to which employees perceive the change as being needed or necessary. Practical implications The results highlight how managerial decisions, approaches to communication - including communication before, during and after CI projects affect project success. The results also show that success depends on the way employees perceive proposed changes. This suggests the need for a more individualized approach to CI, lean, and broader change initiatives. Originality/value This research is the first to fuse project success and sustainability theory to CI projects, beyond Kaizen events, in healthcare environments. The research is particularly important at a time when healthcare organizations are required to make rapid changes with limited resources as they work toward outcome-based assessment and reimbursement rules.

  19. The Role of the Project Management Office on Information Technology Project Success

    Stewart, Jacob S.

    2010-01-01

    The rate of failed and challenged Information Technology (IT) projects is too high according to the CHAOS Studies by the Standish Group and the literature on project management (Standish Group, 2008). The CHAOS Studies define project success as meeting the triple constraints of scope, time, and cost. Assessing critical success factors is another…

  20. CRITICAL SUCCESS FACTORS FOR INFRASTRUCTURE EUROPEAN FUNDED PROJECTS

    Sebastian-Ion Ceptureanu

    2016-07-01

    Full Text Available Absorption of European funds is on top of Romania’s public agenda for the last years although the first programming period has ended and the necessary lessons were learned so far. To have a high degree of absorption of funds provided by the EU must be of quality projects and their implementation to be successful. Through this work we aimed to investigate the success factors of infrastructure projects with European funding in Romania, Bulgaria, Moldova, Ukraine, Serbia and Kosovo, and identify critical success factors of these projects through a research surveying the teams of consultants and support personnel from the countries in an international consulting company. The research results are therefore constitute the empirical evidence of what constitutes critical success factors of infrastructure projects financed by the European Union and can be used as a starting point for scientific studies of the management of European projects or other actions that investigates measures that can be taken to improve the success rate of projects implemented in the area mentioned above.One of the contributions of this paper is to identify the critical success factors of success factors present in literature. With more so as they are critical success factors of infrastructure projects with European funding still required field studies and analysis performed in the present context. In addition, the critical factors were operationalized in a conceptual framework. Moreover, this framework includes leadership style of project manager as critical success factor has been identified in the research as the most important in the context in which it was conducted. As such, this paper demonstrates, with the necessary limitations, the importance of management style of project managers in the context of specific European funded infrastructure projects. And this is happening even though there are sophisticated project management tools availabe and relevant knowledge exists

  1. Critical Success Factors for Malaysian Construction Projects: An Investigative Review

    Yee Cheong Yong

    2017-05-01

    Full Text Available Construction projects play an important role in the advancement of a nation through infrastructure development that leads to economic growth. They are planned carefully to accomplish certain goals. However, not all the projects achieved the goals as per planned. Many factors contribute to the successes and failures, and it becomes an interesting arena for research. The primary objective of this paper is to outline the development trend of project success measurement globally and locally. The research method employed was to make selected reviews on critical success factors' (CSFs literature and to compare international standards and progress in incorporating human behavioural aspects of project management to the situation in Malaysia. A somewhat similar pattern can be observed in Malaysia where the studies have departed from the usual criteria of time, cost and quality, to define project success in a more holistic way. However, the domestic industry has failed to respond to the emerging trend globally as there has yet been any widely published research on the importance of human-related factors towards project success. A consolidated framework of CSFs has therefore, been proposed in responding to the findings. This paper fulfils an identified need as there has been a dearth of research on the subject matter locally.

  2. Renewed mer model of integral management

    Janko Belak

    2015-12-01

    Full Text Available Background: The research work on entrepreneurship, enterprise's policy and management, which started in 1992, successfully continued in the following years. Between 1992 and 2011, more than 400 academics and other researchers have participated in research work (MER research program whose main orientation has been the creation of their own model of integral management. Results: In past years, academics (researchers and authors of published papers from Austria, Belgium, Bosnia and Herzegovina, Bulgaria, Byelorussia, Canada, the Czech Republic, Croatia, Estonia, France, Germany, Hungary, Italy, Poland, Romania, Russia, the Slovak Republic, Slovenia, Switzerland, Ukraine, and the US have cooperated in MER programs, coming from more than fifty institutions. Thus, scientific doctrines of different universities influenced the development of the MER model which is based on both horizontal and vertical integration of the enterprises' governance and management processes, instruments and institutions into a consistently operating unit. Conclusions: The presented MER model is based on the multi-layer integration of governance and management with an enterprise and its environment, considering the fundamental desires for the enterprises' existence and, thus, their quantitative as well as qualitative changes. The process, instrumental, and institutional integrity of the governance and management is also the initial condition for the implementation of all other integration factors.

  3. SUCCESS CONCEPT ANALYSIS APPLIED TO THE INFORMATION TECHNOLOGY PROJECT MANAGEMENT

    Cassio C. Montenegro Duarte

    2012-05-01

    Full Text Available This study evaluates the concept of success in project management that is applicable to the IT universe, from the classical theory associated with the techniques of project management. Therefore, it applies the theoretical analysis associated to the context of information technology in enterprises as well as the classic literature of traditional project management, focusing on its application in business information technology. From the literature developed in the first part of the study, four propositions were prepared for study which formed the basis for the development of the field research with three large companies that develop projects of Information Technology. The methodology used in the study predicted the development of the multiple case study. Empirical evidence suggests that the concept of success found in the classical literature in project management adjusts to the environment management of IT projects. Showed that it is possible to create the model of standard IT projects in order to replicate it in future derivatives projects, which depends on the learning acquired at the end of a long and continuous process and sponsorship of senior management, which ultimately results in its merger into the company culture.

  4. A Model of Successful School Leadership from the International Successful School Principalship Project

    David Gurr

    2015-03-01

    Full Text Available The International Successful School Principalship Project (ISSPP has been actively conducting research about the work of successful principals since 2001. Findings from four project books and eight models derived from this project are synthesised into a model of successful school leadership. Building on Gurr, Drysdale and Mulford’s earlier model, the work of school leaders is described as engaging within the school context to influence student and school outcomes through interventions in teaching and learning, school capacity building, and the wider context. The qualities a leader brings to their role, a portfolio approach to using leadership ideas, constructing networks, collaborations and partnerships, and utilising accountability and evaluation for evidence-informed improvement, are important additional elements. The model is applicable to all in leadership roles in schools.

  5. Successful Training Development and Implementation in Plant Modernization Projects

    Kuhn, A.; Schoenfelder, C.

    2012-01-01

    In plant modernization projects, for life extension or power update, the competence development (in particular, job and needs oriented training) of the plant staff plays an important role for ensuring the highest standard of nuclear safety, and for facilitating an economic operation of the plant. This paper describes challenges, methodology, activities, and results obtained so far from an on-going project in Sweden. - - As conclusion, critical factors for a successful staff training in plant modernization projects include a systematic approach to training, a dedicated training management team, and good interfaces between supplier's engineering teams, experienced training providers, and equipment suppliers.

  6. Servant leadership behaviors of aerospace and defense project managers and their relation to project success

    Dominik, Michael T.

    The success of a project is dependent in part on the skills, knowledge, and behavior of its leader, the project manager. Despite advances in project manager certifications and professional development, the aerospace and defense industry has continued to see highly visible and expensive project failures partially attributable to failures in leadership. Servant leadership is an emerging leadership theory whose practitioners embrace empowerment, authenticity, humility, accountability, forgiveness, courage, standing back, and stewardship, but has not yet been fully examined in the context of the project manager as leader. The objective of this study was to examine the relationship between servant leadership behaviors demonstrated by aerospace and defense project managers and the resulting success of their projects. Study participants were drawn from aerospace and defense oriented affinity groups from the LinkedInRTM social media web system. The participants rated their project managers using a 30-item servant leadership scale, and rated the success of their project using a 12-item project success scale. One hundred and fifteen valid responses were analyzed from 231 collected samples from persons who had worked for a project manager on an aerospace and defense project within the past year. The results of the study demonstrated statistically significant levels of positive correlation to project success for all eight servant leadership factors independently evaluated. Using multiple linear regression methods, the servant leadership factors of empowerment and authenticity were determined to be substantial and statistically significant predictors of project success. The study results established the potential application of servant leadership as a valid approach for improving outcomes of projects.

  7. Factors affecting the success of development projects : A behavioral perspective

    Aga, Deribe Assefa

    2016-01-01

    This dissertation sought to examine behavioral-related critical success factors in the context of Non-Governmental Organization (NGO) sector development projects in Ethiopia. The dissertation applied both a cross-sectional survey design and an experimental design in separate settings, and it is

  8. The IT project manager competencies that impact project success – A qualitative research

    Cíntia Cristina Silva de Araújo

    2015-07-01

    Full Text Available Since there is a lack of studies about the relationship of IT project manager competencies and project success, this paper will address the following research question: Which competencies should IT project managers develop in order to achieve success in IT projects? To answer this question, we conducted a qualitative research with an exploratory approach. To collect data, twelve (12 in-depth interviews were done with Brazilian project managers from different companies from several business sectors. The analysis results pointed out that for our respondents the most needed category of competencies are team management, business domain knowledge,  communication, project management and people skills. As other authors have affirmed, technical skills were considered to be less relevant to project success than interpersonal and intrapersonal competencies.

  9. Diversity in research projects - A key to success?

    Henkel, Daniela; Eisenhauer, Anton; Taubner, Isabelle

    2017-04-01

    According to demographers, psychologists, sociologists and economists diverse groups, which are groups of different race, ethnicity, gender and sexual orientation, are more innovative than homogeneous groups. This is also true for groups working together in research collaborations and international cooperation involving a culturally and functionally diverse mix of individuals who have to be integrated into an effective unit - a project team. If the goal is scientific excellence, diversity should be an essential ingredient to conduct science on high level productivity, quality and innovation. Effective teamwork is a key to project success and prime responsibilities of the project manager. Therefore, the project manager has to take into consideration different characteristics such as cultures, languages, and different values related to individual project partners. Here we show how diversity can affect the performance of a research project. Furthermore, the presentation indicates skills and abilities which are required for the management in order to deal also with the challenges of diversity in research projects. The presentation is based on insights experienced in the context of an Innovative Training Network (ITN) project within Marie Skłodowska-Curie Actions of the European HORIZON 2020 program and TRION a Collaborative Research Project in the Framework of the Trilateral Program of the German Research Foundation.

  10. Managing projects for life cycle success : perfecting the process

    Jenkins, A. [TransCanada PipeLines Ltd., Calgary, AB (Canada); Babuk, T. [Empress International Inc., Westwood, NJ (United States); Mohitpour, M. [Tempsys Pipeline Solutions Inc., Vancouver, BC (Canada)

    2004-07-01

    This paper presented a historical summary of traditional project management along with a discussion on the project management and development philosophy that can be used in a large infrastructure company that develops and operates its own projects and facilities. Two case studies from the experiences of TransCanada Pipelines Limited were also presented. It was suggested that companies seeking a first-rate reputation must maintain a long-term focus with emphasis on the improvement of the total process and harmony with the environment and community. This paper explained how project managers can create balance between the proponents, stakeholders, participants and the people and the environment while ensuring a cost effective quality product over time. Successful project managers were shown to understand and manage the components of scope, time, cost, quality, human resources, communication, risk, purchasing, safety and harmony with the community. Project development from the perspective of an owner-operator was presented with reference to consistency in approach and the decision making process. It was concluded that although project managers should focus on controlling and minimizing capital expenditures during project engineering and construction, the many elements that contribute to a project's value should also be recognized. 10 refs., 6 figs.

  11. Conditions, factors and criteria for successful project implementation: generalization of experience of project management

    Feraru Galina Sergeevna

    2014-11-01

    Full Text Available The article addresses issues characterizing features of project management contributing to their competitive advantage; shows the factors and criteria of success of projects and the main reasons for their failures, making the failed efforts of developers to create projects.

  12. Successful integration of fast track projects into turnarounds

    Williams, J. Patrick; Loureiro, Ramon C. [KBC Advanced Technologies, Surrey (United Kingdom)

    2012-07-01

    Fast track projects can provide quick wins and competitive advantage. However, in most cases the implementation of these projects requires a shutdown for installing the necessary tie-ins or integration into an upcoming turnaround (TA). Depending on the nature of the project and complexity of the TA, the integration can be seamless or result in cost or duration overruns and safety incidents. The risk of such overruns and safety incidents increases with the amount of project work to be integrated into the operations, maintenance and inspection schedules to be executed during the TA. The risk further increases with TA size and other factors. If not planned and scheduled properly and in a timely fashion, capital projects, in particular fast track projects trying to take advantage of an upcoming TA, can severely impact both TA performance, and the safety and reliability of the facility until the next opportunity for eliminating the defects introduced during the TA. Successful TAs are those delivered in a safe, on time, on budget manner, and with the quality standards needed for a leak-free start-up and a safe and reliable operation over the next run cycle. This paper discusses the key elements that are required to minimize the TA risks derived from the inclusion of fast track projects and how to establish the cut off criteria to either cancel or defer the project, or delay the TA in order to balance TA scope freeze and the case for compelling economics.(author)

  13. How Healthy Is My Project? Open Source Project Attributes as Indicators of Success

    Piggot, James; Amrit, Chintan Amrit; Petrinja, Etiel; Succi, Giancarlo; El Ioini, Nabil; Sillitti, Alberto

    2013-01-01

    Determining what factors can influence the successful outcome of a software project has been labeled by many scholars and software engineers as a difficult problem. In this paper we use machine learning to create a model that can determine the stage a software project has obtained with some

  14. A Quantitative Examination of Critical Success Factors Comparing Agile and Waterfall Project Management Methodologies

    Pedersen, Mitra

    2013-01-01

    This study investigated the rate of success for IT projects using agile and standard project management methodologies. Any successful project requires use of project methodology. Specifically, large projects require formal project management methodologies or models, which establish a blueprint of processes and project planning activities. This…

  15. Critical Success Factors in Construction Projects (Governmental Projects as a Case Study

    Hatem Khaleefah Al-Ageeli

    2016-03-01

    Full Text Available The importance of the construction sector and its Great role in the provision of services and infrastructure, reduce poverty, improve living conditions and improve the economic situation in the country, impose attention to the way in which the projects implemented for its improvement and to get successful projects. The objective of this research was to determine the criteria for success as well as critical success and failure factors that have a significant impact on project success. A selected 75 engineer (department managers, project managers and engineers are asked to fill the questionnaire form, Sixty-seven valid questionnaire forms were analyzed statistically to get search results, which were as follows : Twelve critical success factors, the most important factors of it were ("contractor financial efficiency ", " security ,political , economic stability ", "the project manager competence" and " Integration and clarity of contract documents " , thirteen critical failure factors, the most important factors of it were ("corruption " , " external circumstances ", "Financial difficulties of owner", and ten success criteria , the most important criteria of it were ("within allocated budget" , " within time period" , "Quality" .

  16. A Synthesis and Survey of Critical Success Factors for Computer Technology Projects

    Baker, Ross A.

    2012-01-01

    The author investigated the existence of critical success factors for computer technology projects. Current research literature and a survey of experienced project managers indicate that there are 23 critical success factors (CSFs) that correlate with project success. The survey gathered an assessment of project success and the degree to which…

  17. Project management practice and its effects on project success in Malaysian construction industry

    Haron, N. A.; Devi, P.; Hassim, S.; Alias, A. H.; Tahir, M. M.; Harun, A. N.

    2017-12-01

    The rapid economic development has increased the demand for construction of infrastructure and facilities globally. Sustainable development and globalization are the new ‘Zeitgeist’ of the 21st century. In order to implement these projects successfully and to meet the functional aim of the projects within their lifetime, an efficient project management practice is needed. The aim of this study is to identify the critical success factors (CSFs) and the extent of use of project management practice which affects project success, especially during the implementation stage. Data were obtained from self-administered questionnaires with 232 respondents. A mixed method of data collection was adopted using semi-structured interview and questionnaire approach. The result of the analysis of data obtained showed that new and emerging criteria such as customer satisfaction, competency of the project team, and performance of subcontractors/suppliers are becoming measures of success in addition to the classic iron triangle’s view of time, cost and quality. An insight on the extent of use of different project management practice in the industry was also achieved from the study.

  18. Ranking the Project Management Success Factors for Construction Project in South India

    Aneesha, K.; Haridharan, M. K.

    2017-07-01

    In Today’s construction industry, to achieve a greater advantage over the firms, success of each project and efficiency is required. Effective Project Management overcomes these types of challenges. This study identifies the success factors which are important for project management in construction project success. From the literature review, 26 factors were found to be critical. Project managers, construction managers, civil engineers, contractors and site engineers were the respondents. After analyzing the data in SPSS software, the dominant factors from the regression analysis are top management support, competent project team, abilities to solve problems, realistic cost and time estimates, information/communication, competency of the project manager are the 6 factors out of 12 in 26 factors. Effective communication between stakeholders got highest priority and client involvement, good leadership, clarity of project goals got second priority. Informal communication gives better results compared to formal communications like written formats. To remove communication barrier with the stakeholders, informal communication like speaking face-to-face with the language this fits for the stakeholders.

  19. A novel approach to transformed biometrics using successive projections

    Gopi, E. S.

    2010-02-01

    Unlike user created password, number of biometrics is limited for creating account in different organizations. Transformed biometrics attempts to solve the problem by transforming the biometric into another form, which is unique to the particular organization. This makes the availability of different transformed biometrics in different organizations transformed from the same biometrics and helps in foolproof transactions. In this article a novel approach to transformed biometrics using successive projection technique is suggested .In the proposed technique, the user can register up to 5*4n-1 organizations if the length of the biometric password is 'n'.

  20. [Case control trial on putative factors antagonising the successful project course of MD thesis projects].

    Scharfenberg, J; Schaper, K; Krummenauer, F

    2015-05-01

    Award of the degree MD has special relevance in Germany since the underlying research project can be started during the qualification for admission to doctoral training. This leads to a large number of thesis projects with a not always sufficiently pronounced enthusiasm and thus poor chances of success. Accordingly a case control study was undertaken in the Department of Human Medicine, Witten/Herdecke University to investigate reported drop-outs of thesis projects. In autumn 2012 all students in the clinical phases of human medicine education were surveyed using a self-conceived questionnaire on previously initiated or terminated thesis projects, "terminated" is defined as the unsuccessful ending of a project after working for at least 3 months. Individually reported thesis terminations were evaluated using defined items in a 4-stage Likert scale regarding thesis plan and project, subsequently, graduate students who successfully completed a project received the same questionnaire. The items possibly corresponding to process determinants were averaged to a total of 7 dimensions prior to the analysis; the resulting scores were normalised in value ranges 0.0 to 1.0 (1.0 = optimal project situation) whereby individual items could be included in several scores. By means of 5 items a primary endpoint from the faculty's perspective on "compliance with formal procedures" was aggregated; by means of a two-sided Wilcoxon test at the 5 % level students with unsuccessful and successful courses were compared along the corresponding scores. 181 of 276 students from 7 study semesters participated in the screening; details of 17 terminations and 23 currently successful courses could be evaluated in the case control study. For significant differences (p thesis projects to the responsible committees. A weakness is the low number of evaluable self-reported drop-outs as well as the overall moderate response rate. Georg Thieme Verlag KG Stuttgart · New York.

  1. Impact of Leadership Styles on Project Success – The Case of a Multinational Company

    Bálint Blaskovics

    2014-11-01

    Full Text Available Literature on project success mainly focused on identifying and analyzing success criteria and critical success factors. Success criteria are used for evaluating the success of a project and critical success factors are those factors which increase the potential for achieving project success. However, the interrelationships among them were rarely analyzed, although researchers highlighted the importance of these interrelationships. The aim of the paper is to identify a leadership style, of which project managers can maximize the potential for achieving project success. Project success is analyzed from the point of view of success criteria. This approach manages the shortcoming mentioned above, the lack of analyzing interrelationships among critical success factors and success criteria. This outcome is drawn from qualitative field research at a subsidiary of a Scandinavian-based multinational company.

  2. How is success or failure in river restoration projects evaluated? Feedback from French restoration projects.

    Morandi, Bertrand; Piégay, Hervé; Lamouroux, Nicolas; Vaudor, Lise

    2014-05-01

    Since the 1990s, French operational managers and scientists have been involved in the environmental restoration of rivers. The European Water Framework Directive (2000) highlights the need for feedback from restoration projects and for evidence-based evaluation of success. Based on 44 French pilot projects that included such an evaluation, the present study includes: 1) an introduction to restoration projects based on their general characteristics 2) a description of evaluation strategies and authorities in charge of their implementation, and 3) a focus on the evaluation of results and the links between these results and evaluation strategies. The results show that: 1) the quality of an evaluation strategy often remains too poor to understand well the link between a restoration project and ecological changes; 2) in many cases, the conclusions drawn are contradictory, making it difficult to determine the success or failure of a restoration project; and 3) the projects with the poorest evaluation strategies generally have the most positive conclusions about the effects of restoration. Recommendations are that evaluation strategies should be designed early in the project planning process and be based on clearly-defined objectives. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Project quality management critical success factors for buildings

    Low, Sui Pheng

    2014-01-01

    The book presents the development of the Construction Quality Assessment System (CONQUAS), Singapore’s de facto quality performance measurement system, explains the application of the Quality Management System (QMS) to manage CONQUAS and identifies 33 critical success factors (CSFs) for achieving high CONQUAS scores. Through CONQUAS, the reader benefits from understanding how the Singapore government developed and implemented the first objective system for measuring what many building professionals have perceived to be elusive quality standards in the construction industry. The book presents both the theoretical concepts as well as the practical aspects to achieving strategic Project Quality Management that is anchored on the CSFs to building best practices. To realistically reflect the practical aspects and challenging issues faced by stakeholders in the construction industry, questionnaire surveys were conducted with building professionals to distinguish the importance level and extent of adoption of the ...

  4. Leadership in Project Management: A Study of the Relationship between Leadership Styles and Industry Type on Project Success

    Barrantes-Guevara, Rita I.

    2013-01-01

    Every year organizations invest billions of dollars in Information Technology (IT) projects; however, IT project success rates continue to be low. Several critical success factors are mentioned in the research literature, the leadership skills of the project manager being one of the most frequently cited in the recent project management…

  5. Common project energy change. The schedule to the success

    Bartosch, Ulrich; Hennicke, Peter; Weiger, Hubert

    2014-01-01

    The energy change is the most important common work of the German after-war history. And it offers a unique collective field of learning, how the socio-ecological transformation can be converted in practice. If the energy change succeeds in an industrial country like Germany, many other countries can follow this example. The Bund fuer Umwelt und Naturschutz Deutschland (BUND) and the Vereinigung Deutscher Wissenschaftler (VDW) show as editors, what now must be done in order that the energy change becomes a success. Because currently threatens the energy change to be slowed down by the policy and talked to death by many stakeholders in the industry. This book demonstrates why the energy change is necessary and how it can succeed. It shows what has to be done and wants to use the existing enthusiasm in order to lead the common project energy change jointly to success. What is needed is a long-term policy that finally takes the reduction of energy consumption in attack.

  6. Software development project success and failure from the supplier's perspective: A systematic literature review

    Savolainen, Paula; Ahonen, Jarmo J.; Richardson, Ita

    2012-01-01

    peer-reviewed In this paper, we consider software development project success and failure from the supplier's perspective. First we clarified concepts in order to be able to exclude review articles on in-house projects, continuous services, the customer's perspective, and software product development, with the aim of providing valid results for supplier firms. We divided success criteria into project success and project management (PM) success, and, in seven articles, identified thre...

  7. The Impact of Organization, Project and Governance Variables on Software Quality and Project Success

    Abbas, Noura; Gravell, Andy; Wills, Gary

    2010-01-01

    In this paper we present a statistically tested evidence about how quality and success rate are correlated with variables reflecting the organization and aspects of its project’s governance, namely retrospectives and metrics. The results presented in this paper are based on the Agile Projects Governance Survey that collected 129 responses. This paper discuss the deep analysis of this survey, and the main findings suggest that when applying agile software development, the quality of software i...

  8. Key Success Factors and Guidance for International Collaborative Design Projects

    Robby Soetanto

    2015-11-01

    Full Text Available In the built environment (BE sector, the co-creation process of design demands understanding of requirements (as viewed by parties involved, mobilisation of tacit knowledge, negotiation, and complex exchange of information. The need to collaborate over distance has further exacerbated the complexity of the process, and, in itself, represents a significant challenge for BE professionals who are increasingly expected to undertake this process within globally distributed virtual teams. The research aims to identify key success factors and develop guidance for international collaborative design projects, via the implementation of collaborative design courses in UK and Canadian universities over three academic years. Questionnaire surveys, focus groups, observation of online meetings, personal reflections provided data for the analysis. The findings reveal the significance of the perceived risk of collaboration and a difference in preferred communication mode between architects and civil/structural engineers. These findings suggest the impact of training in the subject discipline, and that the opportunity for co-located working has helped the development of trust. The guidance is aimed at BE educators who wish to implement this activity in their courses.

  9. Relationships between Leadership and Success in Different Types of Project Complexities

    Müller, Ralf; Geraldi, Joana; Turner, Rodney J.

    2012-01-01

    This is the accepted, refereed and final manuscript to the article We investigate the moderating effect of project complexity on the relationship between leadership competences of project managers and their success in projects. Building on existing studies in leadership and project management we assess the impact of emotional (EQ), intellectual (IQ) and managerial (MQ) leadership competences on project success in different types of project complexities. A cross-sectional survey using the ...

  10. Reinventing project management the diamond approach to successful growth & innovation

    Shenhar, Aaron J.

    2007-01-01

    Projects are the engines that drive innovation from idea to commercialization. In fact, the number of projects in most organizations today is expanding while operations is shrinking. Yet, since many companies still focus on operational excellence and efficiency, most projects fail--largely because conventional project management concepts cannot adapt to a dynamic business environment. Moreover, top managers neglect their company's project activity, and line managers treat all their projects alike--as part of operations. Based on an unprecedented study of more than 600 projects in a variety of businesses and organizations around the globe, "Reinventing Project Management" provides a new and highly adaptive model for planning and managing projects to achieve superior business results.

  11. Application fuzzy multi-attribute decision analysis method to prioritize project success criteria

    Phong, Nguyen Thanh; Quyen, Nguyen Le Hoang Thuy To

    2017-11-01

    Project success is a foundation for project owner to manage and control not only for the current project but also for future potential projects in construction companies. However, identifying the key success criteria for evaluating a particular project in real practice is a challenging task. Normally, it depends on a lot of factors, such as the expectation of the project owner and stakeholders, triple constraints of the project (cost, time, quality), and company's mission, vision, and objectives. Traditional decision-making methods for measuring the project success are usually based on subjective opinions of panel experts, resulting in irrational and inappropriate decisions. Therefore, this paper introduces a multi-attribute decision analysis method (MADAM) for weighting project success criteria by using fuzzy Analytical Hierarchy Process approach. It is found that this method is useful when dealing with imprecise and uncertain human judgments in evaluating project success criteria. Moreover, this research also suggests that although cost, time, and quality are three project success criteria projects, the satisfaction of project owner and acceptance of project stakeholders with the completed project criteria is the most important criteria for project success evaluation in Vietnam.

  12. Success and fail factors in sustainable real estate renovation projects

    Volker, L.

    2011-01-01

    Sustainability remains an important issue for the construction industry. Yet, sustainable real estate developments are still considered as highly ambitious projects. To find out how and why sustainable renovation projects actually became sustainable we systematically evaluated 21 leading Dutch real

  13. Project Administration Techniques for Successful Classroom Collaborative Writing.

    Kryder, LeeAnne Giannone

    1991-01-01

    Focuses on the collaborative writing done for a large report or proposal over a period of several weeks or months in a business writing course. Discusses short-term writing projects and nonwriting tasks for project administration, meeting management, student/instructor conference, project planning and time estimates, and oral presentations. (PRA)

  14. DETERMINANTS AFFECTING THE SUCCESS OF DISTRIBUTION GRID PROJECTS IN BINH THUAN POWER COMPANY, VIETNAM

    Pham Van Tai* & Le Duc Thu

    2017-01-01

    The research identified the critical factors affecting the success of the distribution grid project in Binh Thuan Power Company, clarify the mutual relationship between the critical factors affecting the success of the distribution grid project in Binh Thuan Power Company and recommended and rated the solution to enhance the success of the distribution grid project in Binh Thuan Power Company. The research had found fours critical factors: External factors of project, Controlling and coordina...

  15. Factors that Impact Software Project Success in Offshore Information Technology (IT) Companies

    Edara, Venkatarao

    2011-01-01

    Information technology (IT) projects are unsuccessful at a rate of 65% to 75% per year, in spite of employing the latest technologies and training employees. Although many studies have been conducted on project successes in U.S. companies, there is a lack of research studying the impact of various factors on software project success in offshore IT…

  16. Considerations for successful minority investments in independent power projects

    Bleveans, Lincoln

    1998-01-01

    This article considers the role of lead developers and lead investors, and minority investors in power projects. The risks involved in minority investment without control is examined, and minority investor issues, the 'due diligence' of the minority investor, the need for timely information, and the importance of minority investors to the power project are discussed. (UK)

  17. The importance of procurement negotiations for project success

    Hoezen, M; Volker, L.

    2015-01-01

    The allocation of a contract for public construction projects in Europe usually requires a European tender procedure. This has to do with the size, the use of public means and the complexity of this type of projects. Compared to regular partnerships, it is hard to develop trust between the buyer and

  18. Project management - Factors leading to success or failure

    Kelley, A. J.; Murphy, D. C.

    1974-01-01

    This paper presents initial findings of a study designed to detail the relationships among situational, structural, and process variables as they relate to project effectiveness. In the paper, emphasis is placed on delineating those variables which tend to improve and those which tend to impede project effectiveness.

  19. Successful neural network projects at the Idaho National Engineering Laboratory

    Cordes, G.A.

    1991-01-01

    This paper presents recent and current projects at the Idaho National Engineering Laboratory (INEL) that research and apply neural network technology. The projects are summarized in the paper and their direct application to space reactor power and propulsion systems activities is discussed. 9 refs., 10 figs., 3 tabs

  20. Critical Success Factors of Public-Private-Partnership Projects in ...

    , to identify their relative importance in promoting good governance. Data obtained from experienced professionals and clients in PPP projects were critically analysed using influence index value. A total of 26 constraints and 12 CSFs were ...

  1. Asy2/Mer2: an evolutionarily conserved mediator of meiotic recombination, pairing, and global chromosome compaction.

    Tessé, Sophie; Bourbon, Henri-Marc; Debuchy, Robert; Budin, Karine; Dubois, Emeline; Liangran, Zhang; Antoine, Romain; Piolot, Tristan; Kleckner, Nancy; Zickler, Denise; Espagne, Eric

    2017-09-15

    Meiosis is the cellular program by which a diploid cell gives rise to haploid gametes for sexual reproduction. Meiotic progression depends on tight physical and functional coupling of recombination steps at the DNA level with specific organizational features of meiotic-prophase chromosomes. The present study reveals that every step of this coupling is mediated by a single molecule: Asy2/Mer2. We show that Mer2, identified so far only in budding and fission yeasts, is in fact evolutionarily conserved from fungi (Mer2/Rec15/Asy2/Bad42) to plants (PRD3/PAIR1) and mammals (IHO1). In yeasts, Mer2 mediates assembly of recombination-initiation complexes and double-strand breaks (DSBs). This role is conserved in the fungus Sordaria However, functional analysis of 13 mer2 mutants and successive localization of Mer2 to axis, synaptonemal complex (SC), and chromatin revealed, in addition, three further important functions. First, after DSB formation, Mer2 is required for pairing by mediating homolog spatial juxtaposition, with implications for crossover (CO) patterning/interference. Second, Mer2 participates in the transfer/maintenance and release of recombination complexes to/from the SC central region. Third, after completion of recombination, potentially dependent on SUMOylation, Mer2 mediates global chromosome compaction and post-recombination chiasma development. Thus, beyond its role as a recombinosome-axis/SC linker molecule, Mer2 has important functions in relation to basic chromosome structure. © 2017 Tessé et al.; Published by Cold Spring Harbor Laboratory Press.

  2. SG (steam generators) reliability project builds on Owners Group successes

    Green, S.

    1988-01-01

    In 1987, a five-year Steam Generator Reliability Project was established at the Electric Power Research Institute (EPRI) to deal with outstanding issues, following on from work initiated by the previous utility industry groupings (Steam Generator Owners Groups I and II). The work done by these groups is discussed and a listing of the major objectives of the new project is provided. (U.K.)

  3. Critical success factors influencing the performance of development projects: An empirical study of Constituency Development Fund projects in Kenya

    Debadyuti Das; Christopher Ngacho

    2017-01-01

    The present work attempts to identify critical success factors (CSFs) influencing the performance of development projects based on their key performance indicators (KPIs). It has considered the case of Constituency Development Fund (CDF) projects constructed between 2003 and 2011 in Kenya and secured the perceptions of 175 respondents comprising clients, consultants and contractors involved in the implementation of CDF projects on 30 success variables. Findings reveal that individual items co...

  4. Ole Rømer-Observatoriet

    Buhl, Hans; Knudsen, Ole J.; Nielsen, Axel V.

    Siden 1911 har der ligget et astronomisk observatorium i Århus. Ole Rømer-Observatoriet blev efter en turbulent start drevet af kommunen, indtil Aarhus Universitet i 1956 overtog det. Der har fra tid til anden været både kontroverser og trusler om lukning, men arbejdet på observatoriet har også...... fortæller museumsinspektør Hans Buhl og planetarieleder Ole J. Knudsen, begge Steno Museet, de næste 95 år af observatoriets brogede historie....

  5. Generation of NSE-MerCreMer transgenic mice with tamoxifen inducible Cre activity in neurons.

    Mandy Ka Man Kam

    Full Text Available To establish a genetic tool for conditional deletion or expression of gene in neurons in a temporally controlled manner, we generated a transgenic mouse (NSE-MerCreMer, which expressed a tamoxifen inducible type of Cre recombinase specifically in neurons. The tamoxifen inducible Cre recombinase (MerCreMer is a fusion protein containing Cre recombinase with two modified estrogen receptor ligand binding domains at both ends, and is driven by the neural-specific rat neural specific enolase (NSE promoter. A total of two transgenic lines were established, and expression of MerCreMer in neurons of the central and enteric nervous systems was confirmed. Transcript of MerCreMer was detected in several non-neural tissues such as heart, liver, and kidney in these lines. In the background of the Cre reporter mouse strain Rosa26R, Cre recombinase activity was inducible in neurons of adult NSE-MerCreMer mice treated with tamoxifen by intragastric gavage, but not in those fed with corn oil only. We conclude that NSE-MerCreMer lines will be useful for studying gene functions in neurons for the conditions that Cre-mediated recombination resulting in embryonic lethality, which precludes investigation of gene functions in neurons through later stages of development and in adult.

  6. Robust k-mer frequency estimation using gapped k-mers.

    Ghandi, Mahmoud; Mohammad-Noori, Morteza; Beer, Michael A

    2014-08-01

    Oligomers of fixed length, k, commonly known as k-mers, are often used as fundamental elements in the description of DNA sequence features of diverse biological function, or as intermediate elements in the constuction of more complex descriptors of sequence features such as position weight matrices. k-mers are very useful as general sequence features because they constitute a complete and unbiased feature set, and do not require parameterization based on incomplete knowledge of biological mechanisms. However, a fundamental limitation in the use of k-mers as sequence features is that as k is increased, larger spatial correlations in DNA sequence elements can be described, but the frequency of observing any specific k-mer becomes very small, and rapidly approaches a sparse matrix of binary counts. Thus any statistical learning approach using k-mers will be susceptible to noisy estimation of k-mer frequencies once k becomes large. Because all molecular DNA interactions have limited spatial extent, gapped k-mers often carry the relevant biological signal. Here we use gapped k-mer counts to more robustly estimate the ungapped k-mer frequencies, by deriving an equation for the minimum norm estimate of k-mer frequencies given an observed set of gapped k-mer frequencies. We demonstrate that this approach provides a more accurate estimate of the k-mer frequencies in real biological sequences using a sample of CTCF binding sites in the human genome.

  7. A recent Cleanroom success story: The Redwing project

    Hausler, Philip A.

    1992-12-01

    Redwing is the largest completed Cleanroom software engineering project in IBM, both in terms of lines of code and project staffing. The product provides a decision-support facility that utilizes artificial intelligence (AI) technology for predicting and preventing complex operating problems in an MVS environment. The project used the Cleanroom process for development and realized a defect rate of 2.6 errors/KLOC, measured from first execution. This represents the total amount of errors that were found in testing and installation at three field test sites. Development productivity was 486 LOC/PM, which included all development labor expended in design specification through completion of incremental testing. In short, the Redwing team produced a complex systems software product with an extraordinarily low error rate, while maintaining high productivity. All of this was accomplished by a project team using Cleanroom for the first time. An 'introductory implementation' of Cleanroom was defined and used on Redwing. This paper describes the quality and productivity results, the Redwing project, and how Cleanroom was implemented.

  8. A Research Project on Successful Single-Parent Families.

    Barry, Ann

    1979-01-01

    Studies variables associated with successful single-parent families. Single parents volunteered to share their positive family experiences. Information was sought on ages of family members and length of single-parent family status, education level and income, relations with absent parent, and relations with children. A hypothesis and counseling…

  9. Multiple comparative metagenomics using multiset k-mer counting

    Gaëtan Benoit

    2016-11-01

    Full Text Available Background Large scale metagenomic projects aim to extract biodiversity knowledge between different environmental conditions. Current methods for comparing microbial communities face important limitations. Those based on taxonomical or functional assignation rely on a small subset of the sequences that can be associated to known organisms. On the other hand, de novo methods, that compare the whole sets of sequences, either do not scale up on ambitious metagenomic projects or do not provide precise and exhaustive results. Methods These limitations motivated the development of a new de novo metagenomic comparative method, called Simka. This method computes a large collection of standard ecological distances by replacing species counts by k-mer counts. Simka scales-up today’s metagenomic projects thanks to a new parallel k-mer counting strategy on multiple datasets. Results Experiments on public Human Microbiome Project datasets demonstrate that Simka captures the essential underlying biological structure. Simka was able to compute in a few hours both qualitative and quantitative ecological distances on hundreds of metagenomic samples (690 samples, 32 billions of reads. We also demonstrate that analyzing metagenomes at the k-mer level is highly correlated with extremely precise de novo comparison techniques which rely on all-versus-all sequences alignment strategy or which are based on taxonomic profiling.

  10. Successful project teams (in R&D environment)

    Giesler, Achmed

    2011-09-01

    Full Text Available management tools no longer give project teams a competitive edge - additional qualitative tools are required, following a systems approach. A paradigm shift away from the traditional triangle of budget, brief and time towards a stronger focus on people issues...

  11. Evaluating Managerial Styles for System Development Life Cycle Stages to Ensure Software Project Success

    Kocherla, Showry

    2012-01-01

    Information technology (IT) projects are considered successful if they are completed on time, within budget, and within scope. Even though, the required tools and methodologies are in place, IT projects continue to fail at a higher rate. Current literature lacks explanation for success within the stages of system development life-cycle (SDLC) such…

  12. From Project Management Capabilities to ERP Implementation Success: The Mediating Effect of IT Executives' Capabilities

    Touir, Maatallah

    2016-01-01

    Enterprise resource planning project implementation success is necessary for organizations to enhance productivity and achieve operational efficiency; however, the failure rates of ERP projects remain high, ranging between 10% and 90%, and costing organizations $500,000 to $300 million. The problem addressed in this study was the low success rate…

  13. MERS-coronavirus: From discovery to intervention

    W. Widagdo; N.M.A. Okba (Nisreen); V. Stalin Raj; B.L. Haagmans (Bart)

    2017-01-01

    textabstractMiddle East respiratory syndrome coronavirus (MERS-CoV) still causes outbreaks despite public awareness and implementation of health care measures, such as rapid viral diagnosis and patient quarantine. Here we describe the current epidemiological picture of MERS-CoV, focusing on humans

  14. Ole Rømers mange talenter

    Pedersen, Kurt Møller

    2005-01-01

    Artiklen giver en oversigt over Ole Rømers videnskabelige liv som astronom, fysiker og matematiker samt hans betydning som kongelig embedsmand.......Artiklen giver en oversigt over Ole Rømers videnskabelige liv som astronom, fysiker og matematiker samt hans betydning som kongelig embedsmand....

  15. The Role of Requirements in the Success or Failure of Software Projects

    Hussain, Azham; Mkpojiogu, Emmanuel O.C.; Kamal, Fazillah Mohmad

    2016-01-01

    Requirements engineering is pivotal and central to every successful software development project. There are several reasons why software projects fail; however, poorly elicited, documented, validated and managed requirements contribute grossly to software projects failure. Software project failures are normally very costly and risky and these could even a times be life threatening also. Projects that overlook requirements engineering processes often suffer or are most likely to suffer from fa...

  16. Critical success factors for BOT electric power projects in China: Thermal power versus wind power

    Zhao, Zhen-Yu. [School of Business Administration, North China Electric Power University, Beijing 102206 (China); Zuo, Jian; Zillante, George [School of Natural and Built Environments, University of South Australia, Adelaide 5001 (Australia); Wang, Xin-Wei [Shandong Nuclear Power Equipment Manufacturing Co. Ltd, Haiyang, Shandong 265118 (China)

    2010-06-15

    Chinese electric power industry has adopted Build-Operate-Transfer (BOT) approach in a number of projects to alleviate the pressure of sole state-owned investment. The Chinese government has taken enormous efforts to create an environment to facilitate the application of BOT approach in electric power projects. Moreover, the growing attention on the sustainability issues puts the traditional major source of electricity - thermal power project under more strict scrutiny. As a result, various renewable energy projects, particularly the wind power projects have involved private sector funds. Both thermal power and wind power projects via BOT approach have met with a varying degree of success. Therefore, it is imperative to understand the factors contributing towards the success of both types of BOT power projects. Using an extensive literature survey, this paper identifies 31 success factors under 5 categories for Chinese BOT electric power projects. This is followed by a questionnaire survey to exam relative significance of these factors. The results reveal the different levels of significance of success factors for BOT thermal power projects versus wind power projects. Finally, survey results were analyzed to explore the underlying construction and distributions among the identified success factors. This study provides a valuable reference for all involved parties that are interested in developing BOT electric power projects in China. (author)

  17. The Role and the Effects of Risk Management in IT Projects Success

    Otniel DIDRAGA

    2013-01-01

    Full Text Available The success of IT projects is influenced by risk and risk management according to the existing project management literature. The paper emphasizes the role of risk management and its contribution to projects success in the existing literature. The methodology applied is based on documentary study review and analysis of the concepts used by the literature. We analyzed the literature published between 1978 and 2012 from the main IT project management journals and publications. The results are that risk management is a very important component of the project management process and it is assumed implicitly to work in favour of project success. We also performed a quantitative analysis of how risk management processes affect the subjective and objective performance of IT projects in Romanian IT companies.

  18. Success Rates by Software Development Methodology in Information Technology Project Management: A Quantitative Analysis

    Wright, Gerald P.

    2013-01-01

    Despite over half a century of Project Management research, project success rates are still too low. Organizations spend a tremendous amount of valuable resources on Information Technology projects and seek to maximize the utility gained from their efforts. The author investigated the impact of software development methodology choice on ten…

  19. Impact of Functional Characteristics on Usage of LSS Methods in IT and Perceived Project Success

    Mushi, Francis Jeremiah

    2014-01-01

    High rates of Information Technology (IT) project failures continues; fail to meet established deadlines, exceeding budget, or not agreed-upon functionality. Failure often results from a fundamental confusion over what is involved in the project. Methods that have provided project success in Service and Manufacturing industries have not been…

  20. Legal and Political Obstacles and Opportunities for Successful Nuclear Projects

    Yanovskiy, M.

    2014-01-01

    Every business suffers from excessive regulations, unpredictable changes in legislation, various kinds of the political rent, extorting practices like 'big business social responsibility' and more. The industries with long-term return-of-investment (ROI) are most vulnerable to political and legal risks. For the nuclear industry, long-lasted public perception of radiation as an imminent threat caused the present over-regulation look natural. Therefore ROI is above two decades, essentially precluding private entrepreneurship activity. While durable solution includes changing public perception and updating regulation, both are 'facts on the ground' and 'habits are hard to break'. Political alliances, appeal to public opinion and lobbying are legitimate methods for promoting industry's interests in a democratic state. However in case of the nuclear industry, bureaucratic and political interests seem too strong to be overpowered by regular lobbying activities. Durable solutions we are searching for should not only eliminate the present legal and political obstacles, but also prevent them in near- to middle-term future. Such solutions would mitigate risks and remove barriers in number of industries, including nuclear industry as well. Particularly, 'not in my backyard' (NIMBY) attitude to nuclear installations is often viewed as a formidable problem. However, this problem has pretty old and reliable solution via compensation for real estate devaluation, if such takes place. Such solution may preclude some projects, but makes others predictable and reliable (e.g. in sparsely populated or relatively poor areas)

  1. The effect of multiple external representations (MERs) worksheets toward complex system reasoning achievement

    Sumarno; Ibrahim, M.; Supardi, Z. A. I.

    2018-03-01

    The application of a systems approach to assessing biological systems provides hope for a coherent understanding of cell dynamics patterns and their relationship to plant life. This action required the reasoning about complex systems. In other sides, there were a lot of researchers who provided the proof about the instructional successions. They involved the multiple external representations which improved the biological learning. The researcher conducted an investigation using one shoot case study design which involved 30 students in proving that the MERs worksheets could affect the student's achievement of reasoning about complex system. The data had been collected based on test of reasoning about complex system and student's identification result who worked through MERs. The result showed that only partially students could achieve reasoning about system complex, but their MERs skill could support their reasoning ability of complex system. This study could bring a new hope to develop the MERs worksheet as a tool to facilitate the reasoning about complex system.

  2. Projecting the success of plant restoration with population viability analysis

    Bell, T.J.; Bowles, M.L.; McEachern, A.K.; Brigham, C.A.; Schwartz, M.W.

    2003-01-01

    Conserving viable populations of plant species requires that they have high probabilities of long-term persistence within natural habitats, such as a chance of extinction in 100 years of less than 5% (Menges 1991, 1998; Brown 1994; Pavlik 1994; Chap. 1, this Vol.). For endangered and threatened species that have been severely reduces in range and whose habitats have been fragmented, important species conservation strategies may include augmenting existing populations or restoring new viable populations (Bowles and Whelan 1994; Chap. 2, this Vol.). Restoration objectives may include increasing population numbers to reduce extinction probability, deterministic manipulations to develop a staged cohort structure, or more complex restoration of a desired genetic structure to allow outcrossing or increase effective population size (DeMauro 1993, 1994; Bowles et al. 1993, 1998; Pavlik 1994; Knapp and Dyer 1998; Chap. 2, this Vol.). These efforts may require translocation of propagules from existing (in situ) populations, or from ex situ botanic gardens or seed storage facilities (Falk et al. 1996; Guerrant and Pavlik 1998; Chap. 2, this Vol.). Population viability analysis (PVA) can provide a critical foundation for plant restoration, as it models demographic projections used to evaluate the probability of population persistence and links plant life history with restoration strategies. It is unknown how well artificially created populations will meet demographic modeling requirements (e.g., due to artificial cohort transitions) and few, if any, PVAs have been applied to restorations. To guide application of PVA to restored populations and to illustrate potential difficulties, we examine effects of planting different life stages, model initial population sizes needed to achieve population viability, and compare demographic characteristics between natural and restored populations. We develop and compare plant population restoration viability analysis (PRVA) case studies of

  3. Avoiding failure: tools for successful and sustainable quality-improvement projects

    Donnelly, Lane F. [Texas Children' s Hospital, Department of Radiology, Houston, TX (United States)

    2017-06-15

    Involvement in successful and sustained quality improvement can be a very rewarding experience. However, it can be very difficult work. Up to 70% of attempted organizational change is not sustained. There are many reasons why quality-improvement projects might not be successful. In this article, the author reviews items associated with an increased or decreased likelihood of success. Such items have been categorized as structural issues, human issues and environmental context. This paper is intended to serve those embarking on quality-improvement projects as a resource to help position them for success. (orig.)

  4. Avoiding failure: tools for successful and sustainable quality-improvement projects

    Donnelly, Lane F.

    2017-01-01

    Involvement in successful and sustained quality improvement can be a very rewarding experience. However, it can be very difficult work. Up to 70% of attempted organizational change is not sustained. There are many reasons why quality-improvement projects might not be successful. In this article, the author reviews items associated with an increased or decreased likelihood of success. Such items have been categorized as structural issues, human issues and environmental context. This paper is intended to serve those embarking on quality-improvement projects as a resource to help position them for success. (orig.)

  5. Avoiding failure: tools for successful and sustainable quality-improvement projects.

    Donnelly, Lane F

    2017-06-01

    Involvement in successful and sustained quality improvement can be a very rewarding experience. However, it can be very difficult work. Up to 70% of attempted organizational change is not sustained. There are many reasons why quality-improvement projects might not be successful. In this article, the author reviews items associated with an increased or decreased likelihood of success. Such items have been categorized as structural issues, human issues and environmental context. This paper is intended to serve those embarking on quality-improvement projects as a resource to help position them for success.

  6. Critical success factors influencing the performance of development projects: An empirical study of Constituency Development Fund projects in Kenya

    Debadyuti Das

    2017-12-01

    Full Text Available The present work attempts to identify critical success factors (CSFs influencing the performance of development projects based on their key performance indicators (KPIs. It has considered the case of Constituency Development Fund (CDF projects constructed between 2003 and 2011 in Kenya and secured the perceptions of 175 respondents comprising clients, consultants and contractors involved in the implementation of CDF projects on 30 success variables. Findings reveal that individual items constituting these six factors represent six CSFs namely project-related, client-related, consultant-related, contractor-related, supply chain-related, and external environment-related factor. The findings are also relevant to development projects undertaken in other developing countries.

  7. The success of international development projects, trust and communication: an African perspective

    Diallo, A.; Thuillier, D. [Universite du Quebec a Montreal (Canada). Dept. Management et Technologie

    2005-04-01

    Project success is strongly linked to communication and cooperation between stakeholders. This research explores the relationship between trust and communication and tests the influence of these factors upon project success and success criteria for international development projects financed by multilateral institutions in sub-Saharan Africa. The research analyses the coordinators' perceptions of project success, communication climate and interpersonal relationship between himself and his stakeholders (task manager in the multilateral agency, national supervisor) and within the project team. Data were collected from questionnaires completed by project coordinators of development projects. The statistical analysis confirms that trust and communication between players are proxy variables. Trust between the task manager and the coordinator is the key success factor, whereas team cohesion is the second most important factor. Trust between the coordinator and his national supervisor does not play a prominent role, although the task manager considers significant local autonomy for the coordinator a prerequisite for funding a subsequent phase when the project comes to an end. (author)

  8. Wind energy planning in England, Wales and Denmark: Factors influencing project success

    McLaren Loring, Joyce

    2007-01-01

    Land-use planning poses a significant barrier to the further development of on-shore wind energy in many countries. There has been increasing discussion regarding the use of public participation in the planning process in order to address concerns of local residents and ease conflicts. This research explores the dynamics of the planning process for wind energy in England, Wales and Denmark in order to better understand the factors influencing project success. Through 18 in-depth case studies, it investigates the degree of local community participation in the planning process and the stability of the network of individuals and organisations involved in the project to determine their relationship to the public's acceptance of the project and the planning outcome. The study draws on the frameworks of public participation in planning and actor-network theories in order to develop indicators of the level of community involvement and network formation for each case. The analysis discusses predictions made by the theoretical approaches as to the importance of these variables to the success of new projects. The results indicate that projects with high levels of participatory planning are more likely to be publicly accepted and successful. In addition, stable supporting networks are more likely to form. The presence of a stable network of supporters is not found to be related to project acceptance and success; however, the absence of a stable network of opponents is found to be necessary for project acceptance and success in receiving planning permission

  9. Metagenome Fragment Classification Using -Mer Frequency Profiles

    Gail Rosen

    2008-01-01

    Full Text Available A vast amount of microbial sequencing data is being generated through large-scale projects in ecology, agriculture, and human health. Efficient high-throughput methods are needed to analyze the mass amounts of metagenomic data, all DNA present in an environmental sample. A major obstacle in metagenomics is the inability to obtain accuracy using technology that yields short reads. We construct the unique -mer frequency profiles of 635 microbial genomes publicly available as of February 2008. These profiles are used to train a naive Bayes classifier (NBC that can be used to identify the genome of any fragment. We show that our method is comparable to BLAST for small 25 bp fragments but does not have the ambiguity of BLAST's tied top scores. We demonstrate that this approach is scalable to identify any fragment from hundreds of genomes. It also performs quite well at the strain, species, and genera levels and achieves strain resolution despite classifying ubiquitous genomic fragments (gene and nongene regions. Cross-validation analysis demonstrates that species-accuracy achieves 90% for highly-represented species containing an average of 8 strains. We demonstrate that such a tool can be used on the Sargasso Sea dataset, and our analysis shows that NBC can be further enhanced.

  10. Examining Success Factors Related to ERP Implementations in Higher Education Shared Services Projects

    Stoyanoff, Dawn Galadriel Pfeiffer

    2012-01-01

    This study examined the enterprise resource planning (ERP) implementations that utilized a shared services model in higher education. The purpose of this research was to examine the critical success factors which were perceived to contribute to project success. This research employed a quantitative non-experimental correlational design and the…

  11. Impact of Requirements Elicitation Processes on Success of Information System Development Projects

    Bormane Līga

    2016-12-01

    Full Text Available Requirements articulating user needs and corresponding to enterprise business processes are a key to successful implementation of information system development projects. However, the parties involved in projects frequently are not able to agree on a common development vision and have difficulties expressing their needs. Several industry experts have acknowledged that requirements elicitation is one of the most difficult tasks in development projects. This study investigates the impact of requirements elicitation processes on project outcomes depending on the applied project development methodology.

  12. Risk Management Affecting IS/IT Project Success Through Communicative Action

    de Bakker, K.F.C.; Boonstra, A.; Wortmann, J.C.

    Project risk management is defined in the literature as being instrumental action based on rational problem solving. Research indicates limited positive effects of an exclusive focus of instrumental action on project success. This article proposes to extend this instrumental view through

  13. Digital project management the complete step-by-step guide to a successful launch

    Olson, Taylor

    2016-01-01

    The digital world is growing and changing at a rate that can seem overwhelming to those project managers who have to keep up with it to build customer-facing solutions and applications. It's rare for project managers working in this field to be provided with much direction or a process by which to carry out a project, and there has been next to nothing available specific to these types of projects in the literary marketplace. Digital Project Management: The Complete Step-by-Step Guide to a Successful Launch was developed to fill this gap by providing the knowledge, best practices and proven steps to consistently managing these types of project successfully from end-to-end now, and in the future with just minor adjustments to adapt to changes in technology.

  14. The impact of leadership styles on project success: Case of a telecommunications company

    Tammy Lategan

    2015-06-01

    Full Text Available Challenges within the customer service industry make leadership styles a key factor in the success of customer service project delivery. This research provides an overview of information and knowledge within a corporate environment with an underlying theme of defining leadership styles within the customer service projects environment to ensure successful project delivery. This research aims to investigate the perception of leadership styles required and factors that contribute to successful project delivery effectiveness within a telecommunication customer service environment. A conceptual research model is formulated and is followed by a quantitative research process and analysis. The results of the study identified that employees had a neutral perception to leadership styles however; different leadership styles are important to themselves and the organisation

  15. Designing a Successful Transportation Project: Lessons Learned from the Clean Cities American Recovery and Reinvestment Act Projects

    Kelly, K.; Singer, M.

    2017-09-01

    The largest source of funding for alternative fuel vehicle and infrastructure projects in the U.S. Department of Energy's Clean Cities program's history came from the American Recovery and Reinvestment Act (Recovery Act). In 2009, the 25 cost-share projects totaled nearly $300 million in federal government investment. This effort included the involvement of 50 Clean Cities coalitions and their nearly 700 stakeholder partners who provided an additional $500 million in matching funds to support projects in their local communities. In total, those 25 projects established 1,380 alternative fueling stations and put more than 9,000 alternative fuel and advanced technology vehicles on the road. Together, these projects displaced 154 million gasoline gallon equivalents (GGE) of petroleum and averted 254,000 tons of greenhouse gas (GHG) emissions, while supporting U.S. energy independence and contributing to regional economic development. During post-project interviews, project leaders consistently cited a number of key components - ranging from technical and logistical factors, to administrative capabilities - for accomplishing an effective and impactful project. This report summarizes the high-level project design and administrative considerations for conducting a successful transportation project.

  16. Designing a Successful Transportation Project: Lessons Learned from the Clean Cities American Recovery and Reinvestment Act Projects

    Kelly, Kay L. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Singer, Mark R. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2017-09-28

    The largest source of funding for alternative fuel vehicle and infrastructure projects in the U.S. Department of Energy's Clean Cities program's history came from the American Recovery and Reinvestment Act (Recovery Act). In 2009, the 25 cost-share projects totaled nearly $300 million in federal government investment. This effort included the involvement of 50 Clean Cities coalitions and their nearly 700 stakeholder partners who provided an additional $500 million in matching funds to support projects in their local communities. In total, those 25 projects established 1,380 alternative fueling stations and put more than 9,000 alternative fuel and advanced technology vehicles on the road. Together, these projects displaced 154 million gasoline gallon equivalents (GGE) of petroleum and averted 254,000 tons of greenhouse gas (GHG) emissions, while supporting U.S. energy independence and contributing to regional economic development. During post-project interviews, project leaders consistently cited a number of key components - ranging from technical and logistical factors, to administrative capabilities - for accomplishing an effective and impactful project. This report summarizes the high-level project design and administrative considerations for conducting a successful transportation project.

  17. Key performance indicators for project success on innovative building technology projects

    Mphahlele, Cathy

    2015-12-01

    Full Text Available unconventional building methods can only be deemed to satisfy by way of rational design or Agrèment certification”. Delivering projects through IBTs has introduced a construction environment that has different procurement, supply chain management, building...

  18. The Danish Rejsekortet (Smart Card for Public Transportation); Project Governance for Failure or Success?

    Harboe, Peter Georg; Riis, Eva

    The authors examine a project regarded as a major failure in Danish public investments: The Smart Card for Public Transportation whose introduction was delayed for 9 years with an estimated cost overrun of 125 million EURO. After 3 years of operation, the Smart Card system only covers seven...... of the nine Danish regions and the discussion about giving up the system is continuing. The authors explore the overall conditions set up for these types of projects in the project governance - how project governance conditions a major public IT project and forms the success evaluation. The focus...... is on the whole cycle from project initiation to long-term use of the project results. Data collection is through documentation as governmental reports and evaluations, for example (Rigsrevisionen, 2011; The Comptroller and Auditor General, 2006; Transport Committee, 2011)and semi-structured interviews...

  19. Key factors of project success in family small and medium-sized companies: the theoretical review

    Sinisa Arsic

    2017-10-01

    Full Text Available The paper proposes a systematization of the key success factors of projects, through the theoretical review of family-owned companies operating in the EU market. It is the small and medium companies that in their own way contribute to the overall success of the national economy in terms of economic activity, increased employment, development activities and defining better business environment. The theoretical review observed numerous studies of family businesses, and the contribution of this work is in the systematization of the results of previous research – over three horizons, i.e., over the role of managers in the creation of successful projects (or owner if it is a family enterprise, institutional support for companies in Serbia and the EU, specific industries and the parent (regional markets where a family company operates. Project management, as a general representation of the concept of implementation of strategic and operational endeavors, contains many specifics in terms of critical success factors of projects depending on the environment in which they are implemented. The goal of the paper is reflected in the identification and presentation of critical success factors of projects implemented in family companies. The paper concludes with a discussion of the research results in relation to the existing, similar research studies, as well as with the announcement of future research, which will examine the conclusions drawn on a real sample.

  20. CRITICAL SUCCESS FACTORS FOR BROWN-FIELD CAPITAL AND RENEWAL PROJECTS

    J. Warchol

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: Manufacturing companies operate in a business environment where incremental growth may be achieved through expansion and renewal of existing plant and facilities. Effective management of the critical success factors of such capital development projects may also provide competitive advantage. These projects tend to be of a brown-field nature, characterised by a significant level of risk arising from the interaction between the project implementation and concurrent operation of the existing physical asset base. So it is vital to understand the factors that influence the success of capital expansion and renewal projects in the brown-field context. Although each project has unique features, there are critical success factors that can be customised for successful outcomes in the brown-field environment. This study identifies five critical success factors applicable to brown-field capital expansion and renewal projects. Managerial focus on the critical factors, and the prospects for successful brown-field projects, are discussed in the paper.

    AFRIKAANSE OPSOMMING: Vervaardigers funksioneer in ‘n sakeomgewing waar voortgesette groei bereik word via uitbreiding en hernuwing van bestaande fasiliteite. Die doeltreffende bestuur van kritiese suksesfaktore van sodanige kapitaalprojekte bied geleentheid vir mededingende voordeel. Projekte van hierdie aard neig om geklassifiseer te word as van herontwikkelingsaard, met betekenisvolle gepaardgaande risiko wat voortspruit uit die interaksie tussen projekimplementering en gelyktydige bedryf van bestaande fisiese bates. Derhalwe is dit belangrik om in die konteks van herontwikkeling aandag te gee aan die kritiese faktore wat ‘n rol speel in die bereiking van sukses. Die navorsing identifiseer vyf kritiese suksesfaktore van belang vir uitbreidings- en vernuwingsprojekte.

  1. Factors of human capital related to project success in health care work units.

    Suhonen, Marjo; Paasivaara, Leena

    2011-03-01

    To explore factors of human capital related to project success that employees expect from nurse managers. Human capital refers to those resources that managers working with projects possess, such as abilities, knowledge and qualities of character. The data were collected by open interviews (n=14) with nurses, public health nurses and nurse managers working in primary health care and a hospital. Data analysis was carried out using qualitative content analysis. The main factors of human capital related to project success proved to be as follows: (1) management of enthusiastic project culture, (2) management of regeneration and (3) management of emotional intelligence. Future research is needed on the kind of means nurse managers use in human capital management in projects and how they see their possibilities in managing human capital. Human capital management skills should be underlined as an important competence area when recruiting a nurse manager. The success of health care projects cannot be improved only through education or by training of nurse managers; in addition, projects need nurse managers who understand workplace spirituality and have high emotional intelligence. © 2011 The Authors. Journal compilation © 2011 Blackwell Publishing Ltd.

  2. Sur terre comme sur mer: organisations spatiales en mer du Nord et mer de Norvège

    Maryvonne LE BERRE

    1998-09-01

    Full Text Available L'article montre, au moyen de représentations cartographiques et graphiques, les structures spatiales développées en mer pour l'exploitation des hydrocarbures. Malgré les différences de milieu, l'appropriation et l'occupation territoriales du domaine maritime s'effectuent selon les mêmes principes que sur le continent, à ceci près que ce qui s'étale en surface sur le continent se développe à la verticale en mer.

  3. Simrank: Rapid and sensitive general-purpose k-mer search tool

    DeSantis, T.Z.; Keller, K.; Karaoz, U.; Alekseyenko, A.V; Singh, N.N.S.; Brodie, E.L; Pei, Z.; Andersen, G.L; Larsen, N.

    2011-04-01

    Terabyte-scale collections of string-encoded data are expected from consortia efforts such as the Human Microbiome Project (http://nihroadmap.nih.gov/hmp). Intra- and inter-project data similarity searches are enabled by rapid k-mer matching strategies. Software applications for sequence database partitioning, guide tree estimation, molecular classification and alignment acceleration have benefited from embedded k-mer searches as sub-routines. However, a rapid, general-purpose, open-source, flexible, stand-alone k-mer tool has not been available. Here we present a stand-alone utility, Simrank, which allows users to rapidly identify database strings the most similar to query strings. Performance testing of Simrank and related tools against DNA, RNA, protein and human-languages found Simrank 10X to 928X faster depending on the dataset. Simrank provides molecular ecologists with a high-throughput, open source choice for comparing large sequence sets to find similarity.

  4. Modelling the critical success factors of agile software development projects in South Africa

    Tawanda B. Chiyangwa

    2017-10-01

    Full Text Available Background: The continued in failure of agile and traditional software development projects have led to the consideration, attention and dispute to critical success factors that are the aspects which are most vital to make a software engineering methodology fruitful. Although there is an increasing variety of critical success factors and methodologies, the conceptual frameworks which have causal relationship are limited. Objective: The objective of this study was to identify and provide insights into the critical success factors that influence the success of software development projects using agile methodologies in South Africa. Method: Quantitative method of collecting data was used. Data were collected in South Africa through a Web-based survey using structured questionnaires. Results: These results show that organisational factors have a great influence on performance expectancy characteristics. Conclusion: The results of this study discovered a comprehensive model that could provide guidelines to the agile community and to the agile professionals.

  5. Success probability orientated optimization model for resource allocation of the technological innovation multi-project system

    Weixu Dai; Weiwei Wu; Bo Yu; Yunhao Zhu

    2016-01-01

    A success probability orientated optimization model for resource al ocation of the technological innovation multi-project system is studied. Based on the definition of the technological in-novation multi-project system, the leveling optimization of cost and success probability is set as the objective of resource al ocation. The cost function and the probability function of the optimization model are constructed. Then the objective function of the model is constructed and the solving process is explained. The model is applied to the resource al ocation of an enterprise’s technological innovation multi-project system. The results show that the pro-posed model is more effective in rational resource al ocation, and is more applicable in maximizing the utility of the technological innovation multi-project system.

  6. The Marketplace Variables in Successful and Unsuccessful NPD Projects in Technology Intensive Companies

    Haverila, Matti

    2010-01-01

    We present an exploratory investigation of how managers conceptualize and perceive ‘marketplace’ variables in successful and unsuccessful New Product Development (NPD) projects, and explore the role that marketplace variables play in differentiating between successful and unsuccessful NPD outcomes. Limitations and future research directions are also discussed. Our findings indicate that managers perceive the marketplace in multiple ways during the NPD process and also that differences exis...

  7. Success factors for international HTA projects: evaluating EUnetHTA Joint Action as an exemplar.

    Guegan, Eleanor Woodford; Cook, Andrew

    2014-11-01

    Evaluation is essential for the management of international projects or networks in health technology assessment (HTA). It extends beyond the normal process of project management by incorporating qualitative dimensions and provides information about a project's effectiveness and achievements. This article aimed to identify the factors that are important for the success of international HTA projects. The European network for Health Technology Assessment Joint Action (EUnetHTA JA) is presented as an exemplar. METHODS for the evaluation of international HTA projects include interviews, focus groups, questionnaires, observations and documentary review, and the key points of these approaches have been summarized. The impact and effectiveness of the EUnetHTA JA was evaluated by questionnaires of project participants and external stakeholders, and by documentary review. The response rate for the three annual questionnaires sent to project participants ranged from 86 percent to 88 percent and for external stakeholders ranged from 65 percent to 88 percent. Key factors for project success included production of deliverables according to the workplan, achievement of objectives, added value generated, effective communication, involvement of external stakeholders, workstream management and progress from the preceding EUnetHTA 2006-2008 project. The experience of this project can inform the evaluation of future international HTA collaborations, such as the EUnetHTA 2nd Joint Action and HTAsiaLink. A high response rate was achieved to the self-completion questionnaires and the strategy followed is recommended for evaluation of international HTA projects. Future assessments of international HTA projects should strive to measure outcomes and impact, not just outputs and process.

  8. Fernald closure project - Lessons learned in the execution of this successful project, completed October 2006

    Murphy, Cornelius; Reising, Johnny

    2007-01-01

    Available in abstract form only. Full text of publication follows: This paper explores the history and lessons learned on the United States' Department of Energy's (DoE's) Fernald Closure Project - from the completion of the uranium-production mission to the implementation of the Records of Decision defining the cleanup standards and the remedies that were achieved. Cleaning up Fernald and returning it to the people of Ohio was a $4.4 billion dollar mega environmental-remediation project that was completed in October 2006. During a period of nearly 37 years, Fernald produced 250,000 tons of high-purity, low-enriched uranium for the U.S. defense program, generating more than six million tons of liquid and solid waste as it carried out its Cold War mission. The facility was shut down in 1989 and clean up began in 1992, when Fluor won the contract to clean up the site. The project comprised four phases: 1. Determining the extent of damage to the environment and groundwater at, and adjacent to, the production facilities 2. Selecting cleanup criteria - final end states that had to be met to protect human health and the environment 3. Selecting and implementing the remedial actions that would meet the cleanup goals 4. Doing the work safely, compliantly and cost-effectively. In the project's early stages, there were strained relationships and total distrust between the local community and the DOE as a result of aquifer contamination and potential health effects to the workers and local residents. (authors)

  9. Examining the Interrelationship among Critical Success Factors of Public Private Partnership Infrastructure Projects

    Shiying Shi

    2016-12-01

    Full Text Available Examining the interrelationships among critical success factors (CSFs for public private partnership (PPP projects is of importance for improving PPP project performance and maintaining the sustainability of PPP project implementation. Previous studies mostly focused on the identification of the CSFs for PPP projects; limited studies investigated the interrelationships among CSFs. Hence, the research objectives are (a to determine the interrelationships among CSFs of PPP projects taking into account the public and (b to identify influence paths contributing to take advantage of CSFs in the process of PPP implementation. A literature review and expert interviews were adopted to construct the CSFs framework; nine hypotheses were constructed and tested by the structural equation modelling (SEM based on the data collected from a questionnaire survey. This research reveals that the relationship between public and private partners is the leader-follower relationship, not the partnership relationship, in PPP projects, indicating that the responsibilities, power or resources existing among partners are very unequal. It also highlights that public involvement has a negative effect on the process of service provisions, and costs and risks exist in the process of public involvement in PPP projects. The determined interrelationships among CSFs will contribute to the sustainability and success of a PPP project.

  10. How internal audit can contribute to the success of ERP implementation projects in an Irish context.

    Bennett, John Michael Anthony

    2014-01-01

    non-peer-reviewed The aim of this study is to explore how Internal Audit can contribute towards the successful implementation of ERP (Enterprise Resource Planning) projects in an Irish context. ERP projects are well documented for high failure rates and adverse impact on receiving businesses. Although there is limited literature available concerning the role of Internal Audit within ERP implementations, there is plenty available relating to ERP implementations which document risks, problem...

  11. Information System Development: Can Traditional Project Management Tools Be Successful in Post-Industrial Organizations?

    Carugati, Andrea

    2002-01-01

    Literature on project management of information systems development suggests practices based on success stories in industrial organizations. Recent trends towards post-industrial organizational forms and loosely coupled networked organizations raise questions regarding the applicability of these ...... of information systems development projects in post-industrial organizations. The guidelines are both the result of post-rationalization of the team members and of the case analysis....

  12. Increasing the Value of Research: A Comparison of the Literature on Critical Success Factors for Projects, IT Projects and Enterprise Resource Planning Projects

    Annie Maddison Warren

    2016-11-01

    Full Text Available Since the beginning of modern project management in the 1960s, academic researchers have sought to identify a definitive list of Critical Success Factors (CSFs, the key things that project managers must get right in order to deliver a successful product. With the advent of Information Technology (IT projects and, more recently, projects to deliver Enterprise Resource Planning (ERP systems, attention has turned to identifying definitive lists of CSFs for these more specific project types. The purpose of this paper is to take stock of this research effort by examining how thinking about each type of project has evolved over time, before producing a consolidated list of CSFs for each as a basis for comparison. This process reveals a high degree of similarity, leading to the conclusion that the goal of identifying a generic list of CSFs for project management has been achieved. Therefore, rather than continuing to describe lists of CSFs, researchers could increase the value of their contribution by taking a step forward and focusing on why, despite this apparent knowledge of how to ensure their success, ERP projects continue to fail.

  13. Experiences of success in industrial plants projects Experiencias exitosas en proyectos de plantas industriales

    Nuria Forcada

    2008-08-01

    Full Text Available Success has always been the ultimate goal of construction projects, and different researchers have tried to evaluate it using different factors. Although specialized industrial construction usually involves very large scale projects with a high degree of technological complexity, research has mostly focused on civil and residential success factors. Experiences in Industrial Plants projects can help to improve project management and productivity in such a specialized sector. In this kind of projects, the contractual arrangement is one of the core differences on Project management and thus project success. This research seeks to develop a schema for classifying critical success factors as well as a methodology for evaluating projects. This methodology was adopted to evaluate critical success factors in Industrial Plants projects with different contractual arrangements. Findings suggest that although the construction stage has been the focus of many studies, the first stages are decisive for the success of projects; contract construction projects consider project planning to be more important; lump sum contract construction projects give greater importance to monitoring the benefits; bidding competition projects consider the available technology with greater rigor, etc. The results indicate that different Industrial Plants projects involve different success factors and management characteristics to achieve project objectives.En cualquier proyecto de construcción el principal objetivo es que sea exitoso y por lo tanto a lo largo del tiempo diferentes investigadores han tratado de evaluar los factores que influyen en el éxito de proyectos. En el ámbito de la construcción estas investigaciones se han enfocado principalmente a obras civiles y residenciales. Este artículo muestra resultados que provienen de proyectos de construcción industrial especializada que incluyen proyectos de gran escala con un alto grado de complejidad tecnol

  14. Characteristics of Successful Internal Medicine Resident Research Projects: Predictors of Journal Publication Versus Abstract Presentation.

    Atreya, Auras R; Stefan, Mihaela; Friderici, Jennifer L; Kleppel, Reva; Fitzgerald, Janice; Rothberg, Michael B

    2018-02-06

    To identify the characteristics of successful research projects at an internal medicine residency program with an established research curriculum. The authors collected data about all research projects initiated by or involving medicine residents from 2006 to 2013 at Baystate Medical Center, using departmental files and institutional review board applications. Resident and mentor characteristics were determined using personnel files and Medline searches. Using multivariable models, the authors identified predictors of successful completion of projects using adjusted prevalence ratios (PRs). The primary outcome was manuscript publication by resident and secondary outcome was either publication or regional/national presentation. Finally, residents were surveyed to identify barriers and/or factors contributing to project completion. Ninety-four research projects were identified: 52 (55.3%) projects achieved the primary outcome and 72 (76.5%) met the secondary outcome, with overlap between categories. Most study designs were cross-sectional (41, 43.6%) or retrospective cohort (30, 31.9%). After adjustment, utilization of the epidemiology/biostatistical core (PR = 2.09; 95% CI: 1.36, 3.21), established publication record of resident (PR = 1.54, 95% CI: 1.14, 2.07), and resident with U.S. medical education (PR = 1.39, 95% CI: 1.02, 1.90) were associated with successful completion of projects. Mentor publication record (PR = 3.13) did not retain significance due to small sample size. Most respondents (65%) cited "lack of time" as a major project barrier. Programs seeking to increase resident publications should consider an institutional epidemiology/biostatistical core available to all residency research projects, and residents should choose experienced mentors with a track record of publications.

  15. The Qinshan phase III project-a successful model of sino-canadian cooperation

    Pang, S.H.H.; Alikhan, S.; Gu Jun

    2005-01-01

    The Qinshan Phase III (CANDU) Project, the largest-scale cooperative project between China and Canada, was completed in 2003 well in advance of the schedule and 10% under budget. The Third Qinshan (Phase III) Nuclear Power Plant (TQNPP) was built in record times: Unit 1 achieved commercial operation on December 31, 2002 and Unit 2 on July 20, 2003, 43 days and 115 days ahead of schedule respectively. Improvements in design and construction methods allowed Unit 1 to be constructed in 51.5 months from First Concrete to Criticality - a record in China for nuclear power plants. The key factors are project management and project management tools, quality assurance, construction methods, electronic documentation with configuration control that provides up-to-date on-line information, CADDS design linked with material management and control. New design and construction techniques were introduced by combining conventional AECL practices with working experiences in China. The most advanced tools and techniques for achieving optimum construction quality, schedule and cost were used. Successful application of advanced project management methods and tools has benefited TQNPC in its subsequent plant operation, and the Chinese contractors in advancing their capabilities in future nuclear projects in China as well as enhancing their opportunities internationally. Excellent co-operation and teamwork within the integrated TQNPC/AECL Commissioning Team with well documented QA program, process and procedures also contributed to the remarkable success of the Project. AECL's initial assessment, based on lessons learned, showed that the project schedule could readily be reduced to 66 months and the capital costs reduced by 25% for a replication project. AECL is building on this experience and successful results of TQNPP in its Advanced CANDU Reactor TM (ACR TM ) ** design. (authors)

  16. Factors determining the success of public private partnership projects in Nigeria

    Afeez Olalekan Sanni

    2016-06-01

    Full Text Available The implementation of public private partnership (PPP procurement method is expected to help governments in the development of infrastructures and provides an opportunity for the reduction in the governments’ debt profiles. This method has been adopted in Nigeria for more than a decade and with these years of implementation, few infrastructural projects have been developed using this method while some have been unsuccessful. This study aims to examine the PPP projects implementation in Nigeria and identify the most critical factors that could determine the success of such projects. A total of 184 questionnaires were received from public and private sectors’ participants in the implementation of PPP projects. An exploratory factor analysis identified seven critical success factors as projects feedback, leadership focus, risk allocation and economic policy, good governance and political support, short construction period, favourable socio-economic factors, and delivering publicly needed service. This study shows that more developmental projects could be delivered through PPP if the government could focus on these main factors in the implementation process. The result will influence policy development towards PPP and guide the partners in the development of PPP projects.

  17. Transformational leadership and project success : The mediating role of team-building

    Aga, Deribe Assefa; Noorderhaven, Niels; Vallejo, Bertha

    2016-01-01

    Although the effect of transformational leadership on project success is empirically supported, less is known about the mechanisms that explain this effect. To address this issue, we propose the mediating role of team-building as a possible explanation of the relationship between transformational

  18. Writing a Successful Fulbright Group Projects Abroad Grant: Voices from a Journey to South Africa

    Kruger, Darrell P.; Gandy, S. Kay; Bechard, Amber; Brown, Randy; Williams, Diane

    2009-01-01

    The authors share a successful Fulbright Group Projects Abroad grant award. The purpose of the grant was to enhance American educators' experience and knowledge of South Africa, in particular, and sub-Saharan Africa more generally. Toward that end, participants experienced a multifaceted view of South Africa's geographical diversity, both physical…

  19. Successful Rural Water Supply Projects and the Concerns of Women. Women in Development.

    Roark, Paula

    As the traditional water carriers and water managers, third world women are crucial to the success of rural water supply projects whose short term goal is increased water quality and quantity and whose long term goal is improved family health. Change depends on the utilization of local learning systems of the society and women are most often the…

  20. Does risk management contribute to IT project success? A meta-analysis of empirical evidence

    de Bakker, K.F.C.; Boonstra, A.; Wortmann, J.C.

    The question whether risk management contributes to IT project success is considered relevant by people from both academic and practitioners' communities already for a long time. This paper presents a meta-analysis of the empirical evidence that either supports or opposes the claim that risk

  1. Management of Interface between Main Contractor and Subcontractors for Successful Project Outcomes

    Harry White

    2014-01-01

    Full Text Available There has been increased dependence on subcontracting within the construction industry, the operational relationship between the Main Contractor (MC and Subcontractor (SC plays a significant role in successful delivery of projects. Through the literature review this paper argues that despite SCs bring added value to construction projects, the increased reliance on SCs has strained relationships between the MC and SC. Also MCs are more concerned with risk and price reduction which undermine the relationship heavily. Current practices in the construction industry in managing SCs were evaluated through a case study and semi-structured interviews. A questionnaire survey was used to investigate the ways of facilitating the interface between the MC and SC in general. The study highlighted that prevailing adverse relationships and culture in the industry are influencing the success of construction projects. The lack of trust is a key factor affecting the relationships between MC and SCs. However, the proactive involvement of the MC with SCs in maintaining continuity of the team from procurement to construction stage and transparency in the processes were key success factors for successful completion of the project.

  2. The role of relationships in collaborative partnership success: Lessons from the Alaska Fourth R project.

    Crooks, Claire V; Exner-Cortens, Deinera; Siebold, Wendi; Moore, Kami; Grassgreen, Lori; Owen, Patricia; Rausch, Ann; Rosier, Mollie

    2018-04-01

    Collaborative partnerships are critical to achieving health equity. As such, it is important to understand what contributes to the success of such partnerships. This paper describes the Alaska Fourth R collaborative, a multisectoral group of agencies (including education, health and human services, the violence against women sector, the governor's council on domestic violence, and an external evaluator) that successfully planned, implemented and evaluated a multi-focus health education program statewide. The purpose of this paper was to explore the ways in which seven pre-identified factors contributed to the successful achievement of the collaborative's goals. This project was grounded in community-based research principles, and collectively, the group chose to use Roussos and Fawcett's (2000) seven-factor model as the basis for the project. Using this model as a guide, semi-structured interviews were conducted with five leaders from the key organizations in the collaborative. In interviews, stakeholders described how each of the seven factors functioned in the Alaska collaborative to contribute to project success, with a particular focus on the critical role of relationships. Three specific relationship facets emerged as cross-cutting themes: flexibility, transparency, and prioritization. In sum, taking the time to build deep and authentic relationships, and then developing a shared vision and mission within the context of relationships that are flexible, transparent and prioritized, provided a strong foundation for future success in this collaborative. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Human Centered Design and Development for NASA's MerBoard

    Trimble, Jay

    2003-01-01

    This viewgraph presentation provides an overview of the design and development process for NASA's MerBoard. These devices are large interactive display screens which can be shown on the user's computer, which will allow scientists in many locations to interpret and evaluate mission data in real-time. These tools are scheduled to be used during the 2003 Mars Exploration Rover (MER) expeditions. Topics covered include: mission overview, Mer Human Centered Computers, FIDO 2001 observations and MerBoard prototypes.

  4. Using the partial least squares (PLS) method to establish critical success factor interdependence in ERP implementation projects

    Esteves, José; Pastor Collado, Juan Antonio; Casanovas Garcia, Josep

    2002-01-01

    This technical research report proposes the usage of a statistical approach named Partial Least squares (PLS) to define the relationships between critical success factors for ERP implementation projects. In previous research work, we developed a unified model of critical success factors for ERP implementation projects. Some researchers have evidenced the relationships between these critical success factors, however no one has defined in a form...

  5. Students Upgrading through Computer and Career Education System Services (Project SUCCESS). Final Evaluation Report 1992-93. OER Report.

    New York City Board of Education, Brooklyn, NY. Office of Educational Research.

    Student Upgrading through Computer and Career Education System Services (Project SUCCESS) was an Elementary and Secondary Education Act Title VII-funded project in its third year of operation. Project SUCCESS served 460 students of limited English proficiency at two high schools in Brooklyn and one high school in Manhattan (New York City).…

  6. A successful waste stream analysis on a large construction project in a radiologically controlled area

    Kennicott, M.; Richardson, D.; Starke, T.P.

    1997-01-01

    The Los Alamos National Laboratory (the Laboratory) Chemistry and Metallurgy Research (CMR) Facility, constructed in 1952, is currently under going a major, multi-year demolition and construction project. Many of the operations required under this project (i.e., design, demolition, decontamination, construction, and waste management) mimic the processes required of a large scale decontamination and decommissioning (D and D) job and are identical to the requirements of any of several upgrades projects anticipated for the laboratory and other Department of Energy (DOE) sites. For these reasons the CMR upgrades Project is seen as an ideal model facility--to test the application and measure the success of waste minimization techniques which could be implemented for any similar projects. The purpose of this paper will be to discuss the successful completion of a waste stream analysis. The analyses performed was to measure the potential impact of waste generation, in terms of volume and costs, for a reconfiguration option being considered to change the approach and execution of the original project

  7. Success Stories in Radiotherapy Development Projects: Lessons Learned from Radiotherapy Development Projects. Chapter 29

    Zubizarreta, E.; Van Der Merwe, D.

    2017-01-01

    This chapter examines some problems found to be common in the process of setting up, running or expanding radiotherapy facilities. The establishment of radiotherapy services is essential to consolidate any national cancer control plan. In other words, such a plan cannot exist without radiotherapy. The IAEA guidance on setting up a radiotherapy programme covering the clinical, medical physics, radiation protection and safety aspects gives an estimate of one teletherapy machine needed per million population]. The IAEA’s Directory of Radiotherapy Centres (DIRAC) shows that the number of megavoltage (MV) machines per million population varies from 8.2 in the United States of America to 5.5 in western Europe. There are still many countries without a single radiotherapy department, especially in Africa, and many others have very low coverage, e.g. up to one external beam radiotherapy machine to cover a population of 35 million, which is close to having no coverage. There are many possible reasons for this situation. In many low income countries, the combination of lower life expectancy, low income taxes, a small budget for public health, and unmet basic needs such as housing, prevention and/or treatment of infectious diseases (malaria, tuberculosis, human immunodeficiency virus (HIV), diarrhoea), drinkable water and sewerage makes the cancer control problem a lower priority. The indicators shown illustrate these points. Establishing a radiotherapy programme requires careful planning, including the requirement for successive phases. Resources should be available for designing, building, purchasing, maintaining and replacing equipment, and for providing training in its use. In the case of a first radiotherapy facility with basic staffing levels, there is not likely to be enough expertise to guide and oversee the process in many or all of these areas.

  8. Leadership Quality for Malaysia Construction Leader to Steer a Success Construction Project

    Ngah Nasaruddin Nur Ain

    2016-01-01

    Full Text Available Issues that dominate the construction industry for the long time such as time overrun, cost overrun, quality of construction and also safety during the construction process are difficult to resolve because of several factors involved which amongst them are leadership quality in the industry. Solving these issues can make the industry more sustainable in nature. This paper presents the need of leadership quality among construction parties involved to steer a construction project successfully. Literature work found that 11 leadership qualities to ensure construction project success. From the frequency analysis, five most dominant leadership qualities are team building, communication skill, visioning, planning & strategy skill, and decision making. Beside the literature, this study also seeks an opinion from a senior leader of a successful construction company regarding the need of these qualities amongst parties to resolve the construction issues. The results from an interview session indicate that he fully agreed with the need of all the qualities in the construction industry. This shows that there is a strong relationship between solving the issues with the leadership quality in ensuring construction project success. These qualities should be further investigated to acquire a better representation of leadership quality in resolving construction issues for Malaysia construction industry.

  9. The Marketplace Variables in Successful and Unsuccessful NPD Projects in Technology Intensive Companies

    Matti J. Haverila

    2010-12-01

    Our findings indicate that managers perceive the marketplace in multiple ways during the NPD process and also that differences exist in metric equivalence across successful and unsuccessful NPD projects. Also, although half of the marketplace variables are positively related to NPD success, managers in Finnish technology companies appear to attach higher relative importance to market attractiveness rather than market competitiveness variables. Marketplace variables appear to be less important than in the Korean and Chinese samples, and much more important than  in the Canadian sample in the Mishra et all study (1996, and similarly much more important than in the Cooper study (1979b.

  10. Key Success Factors of Renewable Energy Projects Implementation in Rural Areas of Indonesia

    Wati Hermawati

    2017-12-01

    Full Text Available This paper is an exploratory study on renewable energy implementation in the rural areas of Indonesia. The study aim was to investigate the factors contributing to the sustainability of renewable energy projects in the rural areas. It mostly uses a qualitative approach. Primary data was mainly obtained from in-depth interviews conducted in site areas with the project owners, project managers, a key person in each local government, industry representatives, and the local community, including local leaders and users of renewable energy. Secondary data in the form of various official project reports was also used. The results indicated that the success of energy project implementation lay not only in good technology performance and long-term maintenance, but was also highly dependent on six key factors, namely: (1 project planning and development; (2 community participation; (3 active communication and beneficiaries; (4 availability of maintenance program, workshop and technician; (5 project management and institutionalization; (6 local government support and networks. The findings from this study provide useful insights to all stakeholders involved in the implementation of renewable energy technology for the rural areas in Indonesia.

  11. INVAP and its project management capabilities: a key to company success

    Salvatore, Marcelo; Delgado, Ricardo; Niklison, Carlos; Ordonez, Juan Pablo; Gerbino, Juan Jose Gil

    2002-01-01

    Over the past 26 years, several factors have contributed to INVAP's projection into domestic and overseas operations. Of these, the most recognized is of course the technological capabilities INVAP keeps developing to satisfy our customer's requirements. In a second thought, the other factor is the strategic objective of providing specific purpose customer oriented solutions. The less obvious third important factor in this trilogy is the successful application of Project Management techniques and methods. INVAP's vision on Project Management encompasses well known concepts as: Integrated Management, Proactive solutions, Cost Control and Reporting, Quality Assurance, Target Schedules, Performance Requirements, Risk Management, Configuration Management and Integrated Logistic Support. After 2 years of execution of the Replacement Research Reactor Project for the Australian Nuclear Science and Technology Organization, our Project Management methodology have allowed us to timely meet all project milestones, complete basic and detail engineering, timely deliver the preliminary safety reports, manufacture and test technological concepts in specifically built mock ups and overcome risky situations -like the economical panorama in Argentina- without jeopardizing our Contractual commitments. Present paper depicts the practical approach INVAP has for Project Management -particularly within the Nuclear Division-, and a description of the tools to such aim developed. (author)

  12. A View on a Successful International Educational Project in Software Engineering

    Zoran Budimac

    2012-01-01

    Full Text Available In this paper, a successful and fruitful joint project will be presented. The project joins participants from 9 countries and from 15 universities. Since it started in 2001, this project entitled “Software Engineering: Computer Science Education and Research Cooperation” helped participants to gain excellent, up to date educational material, apply modern teaching methods, exchange experiences with other participants, and work jointly on the further development of lectures, case-studies, assignments, examination questions, and other necessary elements of a course. Project works under auspices of Stability Pact of South-Eastern Europe, and is supported by DAAD. The project started with the creation of a common beginning course in “Software Engineering”, but over time it grew and the number of other courses was developed. Finished almost completely are the courses in “Object-oriented programming”, “Software Project Management”, “Advanced Compiler Construction”, and “Data Structures and Algorithms”, and some other courses are under development. Aside from the educational collaboration, project members also developed good scientific cooperation, and published several research papers.

  13. Privatization Financing Alternatives: Blending Private Capital and Public Resources for a Successful Project

    BT Oakley; JH Holbrook; L Scully; MR Weimar; PK Kearns; R DiPrinzio

    1998-10-19

    The U.S. Department of Energy (DOE) launched the Contract Reform Initiative in 1994 in order to improve the effectiveness and effkiency of managing major projects and programs. The intent of this initiative is to help DOE harness both technical and market forces to reduce the overall cost of accomplishing DOE's program goals. The new approach transfers greater risk to private contractors in order to develop incentives that align contractor performance with DOE's objectives. In some cases, this goal can be achieved through public-private partnerships wherein the govermhent and the contractor share risks associated with a project in a way that optimizes its economics. Generally, this requires that project risks are allocated to the party best equipped to manage and/or underwrite them. While the merits of privatization are well documented, the question of how privatized services should be financed is often debated. Given the cost of private sector equity and debt, it is difficult to ignore the lure of the government's "risk free" cost of capital. However, the source of financing for a project is an integral part of its overall risk allocation, and therefore, participation by the government as a financing source could alter the allocation of risks in the project, diminishing the incentive structure. Since the government's participation in the project's financing often can be a requirement for financial feasibility, the dilemma of structuring a role for the government without undermining the success of the project is a common and difficult challenge faced by policymakers around the world. However, before reverting to a traditional procurement approach where the government enters into a cost-plus risk profile, the government should exhaust all options that keep the private entity at risk for important aspects of the project. Government participation in a project can include a broad range of options and can be applied with precision to bridge a

  14. Students Upgrading through Computer and Career Education System Services (Project SUCCESS). Final Evaluation Report 1993-94. OER Report.

    Greene, Judy

    Students Upgrading through Computer and Career Education System Services (Project SUCCESS) was an Elementary and Secondary Education Act Title VII-funded project in its fourth year of operation. The project operated at two high schools in Brooklyn and one in Manhattan (New York). In the 1993-94 school year, the project served 393 students of…

  15. An empirical analysis of the relationship between cost of control activities and project management success

    Al-Tmeemy Samiaah

    2018-01-01

    Full Text Available To achieve the objectives of continuous improvement programs, construction managers must link the achievement of quality with cost. This paper aims to associate project management success (PMS with cost of control (COC activities in an empirical manner. Thus, the purpose is to determine the extent to which COC activities impact PMS. Quantitative method was adopted to collect data from Malaysian building companies using postal and email surveys. Hypothesis is tested using correlation and simple linear regression analysis. The findings of this study indicate that COC activities are positively associated with the PMS. The empirical evidences obtained from this research, provides financial justification for all quality improvement efforts. This can assist building contractors to enhance the success of project management by reducing the level of business failures due to poor quality, cost overruns, and delays.

  16. Critical Success Factors of Mobile Application Development Projects: A Qualitative Study

    Hamza Khastar

    2016-07-01

    Full Text Available This study seeks to identify the critical success factors of teams in the application-development project. To achieve this goal, a qualitative approach and content analysis was utilized. Semi-structured interviews with 14 developers and experts was performed for data collection. A systematic review of previous research shows that after 9 critical success factors. With the analysis interviews, the CSf's raised to 12; including user experience, strategy and project management, support and promotion, business models, planning and goal setting, financial and budgeting, marketing and customer needs, infrastructure, technical issues and design, contextual factors, teamwork and staffing. The results show that the customer experience, teamwork and contextual factors are core categories in the research paradigm model.

  17. Investments on Pro-poor Development Projects on Goats: Ensuring Success for Improved Livelihoods.

    Devendra, C

    2013-01-01

    The elements that determine the success of development projects on goats and the prerequisites for ensuring this are discussed in the context of the bewildering diversity of goat genetic resources, production systems, multifunctionality, and opportunities for responding to constraints for productivity enhancement. Key determinants for the success of pro-poor projects are the imperatives of realistic project design, resolution of priorities and positive impacts to increase investments and spur agricultural growth, and appropriate policy. Throughout the developing world, there exist 97% of the total world population of 921 million goats across all agro-ecological zones (AEZs), including 570 breeds and 64% share of the breeds. They occupy a very important biological and socio-economic niche in farming systems making significant multifunctional contributions especially to food, nutrition and financial security, stability of farm households, and survival of the poor in the rural areas. Definitions are given of successful and failed projects. The analyses highlighted in successful projects the value of strong participatory efforts with farmers and climate change. Climate change effects on goats are inevitable and are mediated through heat stress, type of AEZ, water availability, quantity and quality of the available feed resources and type of production system. Within the prevailing production systems, improved integrated tree crops - ruminant systems are underestimated and are an important pathway to enhance C sequestration. Key development strategies and opportunities for research and development (R and D) are enormous, and include inter alia defining a policy framework, resolution of priority constraints using systems perspectives and community-based participatory activities, application of yield-enhancing technologies, intensification, scaling up, and impacts. The priority for development concerns the rainfed areas with large concentrations of ruminants in which

  18. Investments on Pro-poor Development Projects on Goats: Ensuring Success for Improved Livelihoods

    C. Devendra

    2013-01-01

    Full Text Available The elements that determine the success of development projects on goats and the prerequisites for ensuring this are discussed in the context of the bewildering diversity of goat genetic resources, production systems, multifunctionality, and opportunities for responding to constraints for productivity enhancement. Key determinants for the success of pro-poor projects are the imperatives of realistic project design, resolution of priorities and positive impacts to increase investments and spur agricultural growth, and appropriate policy. Throughout the developing world, there exist 97% of the total world population of 921 million goats across all agro-ecological zones (AEZs, including 570 breeds and 64% share of the breeds. They occupy a very important biological and socio-economic niche in farming systems making significant multifunctional contributions especially to food, nutrition and financial security, stability of farm households, and survival of the poor in the rural areas. Definitions are given of successful and failed projects. The analyses highlighted in successful projects the value of strong participatory efforts with farmers and climate change. Climate change effects on goats are inevitable and are mediated through heat stress, type of AEZ, water availability, quantity and quality of the available feed resources and type of production system. Within the prevailing production systems, improved integrated tree crops - ruminant systems are underestimated and are an important pathway to enhance C sequestration. Key development strategies and opportunities for research and development (R and D are enormous, and include inter alia defining a policy framework, resolution of priority constraints using systems perspectives and community-based participatory activities, application of yield-enhancing technologies, intensification, scaling up, and impacts. The priority for development concerns the rainfed areas with large concentrations of

  19. Successful PV SHS project in developing countries? barriers and way foreword

    Villers, T. de; Watchueng, S.; Shanker, A.; Rambaud-Measson, D.

    2004-01-01

    The implementation of a solar home system (SHS) programme in developing countries is complex and its success is dependant on many factors that are usually difficult to handle. The objective of this paper is to address financial and organisational aspects barriers and measures to PV programme implementation drawn from two specific projects in West Africa. Technical aspects on quality control and monitoring are also discussed. (authors)

  20. Leadership Quality for Malaysia Construction Leader to Steer a Success Construction Project

    Ngah Nasaruddin Nur Ain; Abdul Rahman Ismail

    2016-01-01

    Issues that dominate the construction industry for the long time such as time overrun, cost overrun, quality of construction and also safety during the construction process are difficult to resolve because of several factors involved which amongst them are leadership quality in the industry. Solving these issues can make the industry more sustainable in nature. This paper presents the need of leadership quality among construction parties involved to steer a construction project successfully. ...

  1. Success and failure factors for e-government projects: A case from Egypt

    Hatem Elkadi

    2013-07-01

    Full Text Available E-government implementations in developing countries still face difficulties, leading to a large failure ratio. This is too high a cost for developing countries. Analysis of the reasons behind success and failure of e-government projects is still an interesting domain of investigation. Several approaches were advanced and success and failure factors have been stipulated, but factors pertinent to Public Administration have yet to be investigated and analyzed. This work builds on the results of earlier research, analyzing the factors behind the change in performance of the different sites of a specific project, reasons of their original success, and the relapse of one site. It reviews in detail the factors advanced by previous works and integrates for the first time the results obtained by 3 different research methodologies. It clarifies the causality between different factors presumed to individually affect the e-government implementations, thus enabling the disambiguation between the main and secondary less effective causes of failure. The success and failure factors significance and relative importance are identified, revealing the recommended track of action for the set-back remedy.

  2. The pedagogical and ethical legacy of a "successful" educational reform: The Citizen School Project

    Fischman, Gustavo E.; Gandin, Luis Armando

    2016-02-01

    The Citizen School Project (Escola Cidadã) was implemented from 1993 to 2004 in Porto Alegre, capital of the Brazilian state of Rio Grande do Sul. This article presents the conception behind the Citizen School Project, the basic mechanisms created to implement and evaluate its strengths and weaknesses, and some of its contradictions. After contextualising the educational reforms in Brazil during the 1980s and 1990s, the authors demonstrate how the Citizen School Project's emphasis on participation and democratisation was a radical departure from Brazil's traditional public education system. Next, they present the three main goals and structures of the Citizen School Project - democratisation of access to schools, democratisation of schools' administration, and democratisation of access to knowledge. They conclude by discussing some pedagogic, social and political dynamics which appear to be strong legacies of this pedagogical project. The authors also argue that the Citizen School Project has both improved the quality of education in Porto Alegre and is an important contribution to our collective thinking about the politics of "successful" educational policies.

  3. Probability-of-success studies for geothermal projects: from subsurface data to geological risk analysis

    Schumacher, Sandra; Pierau, Roberto; Wirth, Wolfgang

    2017-04-01

    In recent years, the development of geothermal plants in Germany has increased significantly due to a favorable political setting and resulting financial incentives. However, most projects are developed by local communities or private investors, which cannot afford a project to fail. To cover the risk of total loss if the geothermal well should not provide the energy output necessary for an economically viable project, investors try to procure insurances for this worst case scenario. In order to issue such insurances, the insurance companies insist on so called probability-of-success studies (POS studies), in which the geological risk for not achieving the necessary temperatures and/or flow rates for an economically successful project is quantified. Quantifying the probability of reaching a minimum temperature, which has to be defined by the project investors, is relatively straight forward as subsurface temperatures in Germany are comparatively well known due tens of thousands of hydrocarbon wells. Moreover, for the German Molasse Basin a method to characterize the hydraulic potential of a site based on pump test analysis has been developed and refined in recent years. However, to quantify the probability of reaching a given flow rate with a given drawdown is much more challenging in areas where pump test data are generally not available (e.g. the North German Basin). Therefore, a new method based on log and core derived porosity and permeability data was developed to quantify the geological risk of reaching a determined flow rate in such areas. We present both methods for POS studies and show how subsurface data such as pump tests or log and core measurements can be used to predict the chances of a potential geothermal project from a geological point of view.

  4. Relacionamento entre gerenciamento de risco e sucesso de projetos Relationship between risk management and project success

    Roque Rabechini Junior

    2012-01-01

    Full Text Available Este trabalho apresenta os resultados de uma pesquisa feita em quatro estados brasileiros sobre adoção de práticas de gerenciamento de riscos em projetos com diferentes tipos de complexidade. A pesquisa de campo envolveu 415 projetos de nove setores econômicos distintos. O material obtido foi coletado por meio de questionário aplicado em gerentes e membros de equipe de projetos. Os resultados mostraram que há impacto significativo e positivo da adoção de práticas de gerenciamento de riscos no sucesso dos projetos. Mostrou também que há dependência entre percepção de sucesso e presença/ausência de gerente de risco, havendo impacto positivo da presença do gerente de risco no sucesso dos projetos. As principais limitações da pesquisa concernem às escolhas metodológicas de amostra não probabilística, empregando questionário baseado na percepção dos respondentes. O trabalho originalmente integra a visão de práticas de gerenciamento de riscos com resultados em projetos, servindo de base para novos estudos em outros setores e áreas de conhecimento de projetos.This paper presents the results of an investigation in four Brazilian States on the adoption of Risk Management practices in projects with different complexity levels. The field research involved 415 projects from nine different economic sectors. Data was gathered through a questionnaire applied to managers and project team members. Results showed that there are significant and positive impacts in the adoption of Risk Management practices on project success. It also showed that there is dependence between perceived success and the presence/absence of a risk manager, i.e., the presence of a risk manager has positive impacts on project success. The major limitation of this study concerns the methodological choice: non-probability sample survey based on respondents perception. The work promotes the integration between Risk Management practices and projects performance

  5. Project SUCCESS' Effects on Substance Use-Related Attitudes and Behaviors: A Randomized Controlled Trial in Alternative High Schools

    Clark, Heddy Kovach; Ringwalt, Chris L.; Shamblen, Stephen R.; Hanley, Sean M.

    2011-01-01

    Using a randomized controlled effectiveness trial, we examined the effects of Project SUCCESS on a range of secondary outcomes, including the program's mediating variables. Project SUCCESS, which is based both on the Theory of Reasoned Action and on Cognitive Behavior Theory, is a school-based substance use prevention program that targets…

  6. The Students Upgrading through Computer and Career Education Systems Services (Project SUCCESS). 1990-91 Final Evaluation Profile. OREA Report.

    New York City Board of Education, Brooklyn, NY. Office of Research, Evaluation, and Assessment.

    An evaluation was done of the New York City Public Schools' Student Upgrading through Computer and Career Education Systems Services Program (Project SUCCESS). Project SUCCESS operated at 3 high schools in Brooklyn and Manhattan (Murry Bergtraum High School, Edward R. Murrow High School, and John Dewey High School). It enrolled limited English…

  7. K-mer Content, Correlation, and Position Analysis of Genome DNA Sequences for the Identification of Function and Evolutionary Features

    Aaron Sievers

    2017-04-01

    Full Text Available In genome analysis, k-mer-based comparison methods have become standard tools. However, even though they are able to deliver reliable results, other algorithms seem to work better in some cases. To improve k-mer-based DNA sequence analysis and comparison, we successfully checked whether adding positional resolution is beneficial for finding and/or comparing interesting organizational structures. A simple but efficient algorithm for extracting and saving local k-mer spectra (frequency distribution of k-mers was developed and used. The results were analyzed by including positional information based on visualizations as genomic maps and by applying basic vector correlation methods. This analysis was concentrated on small word lengths (1 ≤ k ≤ 4 on relatively small viral genomes of Papillomaviridae and Herpesviridae, while also checking its usability for larger sequences, namely human chromosome 2 and the homologous chromosomes (2A, 2B of a chimpanzee. Using this alignment-free analysis, several regions with specific characteristics in Papillomaviridae and Herpesviridae formerly identified by independent, mostly alignment-based methods, were confirmed. Correlations between the k-mer content and several genes in these genomes have been found, showing similarities between classified and unclassified viruses, which may be potentially useful for further taxonomic research. Furthermore, unknown k-mer correlations in the genomes of Human Herpesviruses (HHVs, which are probably of major biological function, are found and described. Using the chromosomes of a chimpanzee and human that are currently known, identities between the species on every analyzed chromosome were reproduced. This demonstrates the feasibility of our approach for large data sets of complex genomes. Based on these results, we suggest k-mer analysis with positional resolution as a method for closing a gap between the effectiveness of alignment-based methods (like NCBI BLAST and the

  8. Factors Affecting Process Innovation Teams’ Learning and Their Impact on the Success of the Process Innovation Projects

    İbrahim H. Seyrek

    2007-06-01

    Full Text Available Based on 145 process innovation teams, we have studied factors supporting team learning and their impact on the success of the process innovation projects. As a result, we have found that team vision, recording and reviewing project related information, filing, following a structural development process and co-location of team members are factors supporting team learning and project success. Also, two dimensions of learning, information acquisition and information implementation, are positively related to the success of the process innovation projects

  9. The art of implosions has impacted the success of three decontamination and decommissioning projects at Fernald

    Borgman, T.D.

    1997-01-01

    The Department of Energy (DOE) at the Fernald Environmental Management Project (FEMP), near Cincinnati, Ohio, has successfully impacted the safety, cost and schedule goals of the Decontamination and Dismantling (D ampersand D) Program by using the art of implosions. An implosion is the act of bringing a structure down in a well planned and directed manner using explosive materials. Three major structures in three separate projects were imploded using this well known commercial technology. Safety is, and will always be, the major consideration with each of the projects. As each project succeeded another, the work process used new and improved methods to lower the risk to the environment, provide a safer workplace by reducing the exposure of high risk work and reducing the spread of lead, asbestos and radioactive materials. The time frame for dismantlement of the steel structures was greatly improved, thus reducing the total project cost. The lessons learned were incorporated from one project to another, to continually improve the work process. A number of alternatives were considered for the removal of the structures, seven, four and three stories in height. The subcontractor and its demolition sub-tier contractor worked in a fixed price lump sum contract environment. While skeptical at first, the subcontractor realized the benefits of the technology, a win-win situation for all participants. The overall planning of each of the events was tied to the needs of the client (DOE), the stakeholders and the community surrounding the site, and the continuing progress at the Fernald site. The recording and application of several key lessons learned in the sequence of implosions, will be the key issues of interest in this paper. Each project offered interesting opportunities for contingency planning, coordination, safety culture adjustments, and high regard for the protection of surrounding structures

  10. The art of implosions has impacted the success of three decontamination and decommissioning projects at Fernald

    Borgman, T.D.

    1997-12-01

    The Department of Energy (DOE) at the Fernald Environmental Management Project (FEMP), near Cincinnati, Ohio, has successfully impacted the safety, cost and schedule goals of the Decontamination and Dismantling (D&D) Program by using the art of implosions. An implosion is the act of bringing a structure down in a well planned and directed manner using explosive materials. Three major structures in three separate projects were imploded using this well known commercial technology. Safety is, and will always be, the major consideration with each of the projects. As each project succeeded another, the work process used new and improved methods to lower the risk to the environment, provide a safer workplace by reducing the exposure of high risk work and reducing the spread of lead, asbestos and radioactive materials. The time frame for dismantlement of the steel structures was greatly improved, thus reducing the total project cost. The lessons learned were incorporated from one project to another, to continually improve the work process. A number of alternatives were considered for the removal of the structures, seven, four and three stories in height. The subcontractor and its demolition sub-tier contractor worked in a fixed price lump sum contract environment. While skeptical at first, the subcontractor realized the benefits of the technology, a win-win situation for all participants. The overall planning of each of the events was tied to the needs of the client (DOE), the stakeholders and the community surrounding the site, and the continuing progress at the Fernald site. The recording and application of several key lessons learned in the sequence of implosions, will be the key issues of interest in this paper. Each project offered interesting opportunities for contingency planning, coordination, safety culture adjustments, and high regard for the protection of surrounding structures.

  11. Projected near-future levels of temperature and pCO2 reduce coral fertilization success.

    Rebecca Albright

    Full Text Available Increases in atmospheric carbon dioxide (pCO2 are projected to contribute to a 1.1-6.4°C rise in global average surface temperatures and a 0.14-0.35 reduction in the average pH of the global surface ocean by 2100. If realized, these changes are expected to have negative consequences for reef-building corals including increased frequency and severity of coral bleaching and reduced rates of calcification and reef accretion. Much less is known regarding the independent and combined effects of temperature and pCO2 on critical early life history processes such as fertilization. Here we show that increases in temperature (+3°C and pCO2 (+400 µatm projected for this century negatively impact fertilization success of a common Indo-Pacific coral species, Acropora tenuis. While maximum fertilization did not differ among treatments, the sperm concentration required to obtain 50% of maximum fertilization increased 6- to 8- fold with the addition of a single factor (temperature or CO2 and nearly 50- fold when both factors interact. Our results indicate that near-future changes in temperature and pCO2 narrow the range of sperm concentrations that are capable of yielding high fertilization success in A. tenuis. Increased sperm limitation, in conjunction with adult population decline, may have severe consequences for coral reproductive success. Impaired sexual reproduction will further challenge corals by inhibiting population recovery and adaptation potential.

  12. Molecular identification of Lodoicea maldivica (coco de mer seeds

    Mok Chuen-shing

    2011-09-01

    Full Text Available Abstract Background The edible endosperm of Lodoicea maldivica with the common name of coco de mer is used in Chinese medicine for treating cough. Native to Seychelles, Lodoicea maldivica seeds have commanded high prices for centuries due to its scarcity. This study aims to develop a molecular identification method for the authentication of Lodoicea maldivica seeds. Methods DNA was extracted from the sample. Two polymerase chain reaction (PCR systems were developed to amplify a region of the chloroplast DNA and the nuclear phosphoribulokinase (PRK region specific to Lodoicea maldivica respectively. DNA sequence of a sample was determined and compared with that of the Lodoicea maldivica reference material. Results The PRK gene of Lodoicea maldivica was successfully amplified and sequenced for identification. Conclusion A new molecular method for the identification of Lodoicea maldivica seeds in fresh, frozen or dried forms was developed.

  13. Implementation of hierarchical clustering using k-mer sparse matrix to analyze MERS-CoV genetic relationship

    Bustamam, A.; Ulul, E. D.; Hura, H. F. A.; Siswantining, T.

    2017-07-01

    Hierarchical clustering is one of effective methods in creating a phylogenetic tree based on the distance matrix between DNA (deoxyribonucleic acid) sequences. One of the well-known methods to calculate the distance matrix is k-mer method. Generally, k-mer is more efficient than some distance matrix calculation techniques. The steps of k-mer method are started from creating k-mer sparse matrix, and followed by creating k-mer singular value vectors. The last step is computing the distance amongst vectors. In this paper, we analyze the sequences of MERS-CoV (Middle East Respiratory Syndrome - Coronavirus) DNA by implementing hierarchical clustering using k-mer sparse matrix in order to perform the phylogenetic analysis. Our results show that the ancestor of our MERS-CoV is coming from Egypt. Moreover, we found that the MERS-CoV infection that occurs in one country may not necessarily come from the same country of origin. This suggests that the process of MERS-CoV mutation might not only be influenced by geographical factor.

  14. Case history of a successful CO{sub 2} miscible gas WAG injection project

    Harpole, Ken

    1998-07-01

    A successful fieldwide CO{sub 2} miscible gas injection project has been underway at the East Vacuum Grayburg San Andres Unit (EVGSAU) in eastern New Mexico, USA since 1985. This presentation follows the evolution of CO{sub 2} miscible gas WAG injection operations at EVGSAU and discusses some of the significant changes in reservoir strategy management which have been implemented over the past 13 years. These changes parallel the evolution in the industry's understanding of and experience with CO{sub 2} miscible gs injection processes. The operating problems and reservoir management challenges encountered at East Vacuum - injection performance, sweep efficiency, effective management of WAG operations, rapidly changing requirements for handling produced gas, and maintaining efficient utilization of injected CO{sub 2} - reflect the kinds of challenges typically encountered in managing a large CO{sub 2} injection project. 1 fig., 1 tab.

  15. Pay For Success And Population Health: Early Results From Eleven Projects Reveal Challenges And Promise.

    Lantz, Paula M; Rosenbaum, Sara; Ku, Leighton; Iovan, Samantha

    2016-11-01

    Pay for success (PFS) is a type of social impact investing that uses private capital to finance proven prevention programs that help a government reduce public expenditures or achieve greater value. We conducted an analysis of the first eleven PFS projects in the United States to investigate the potential of PFS as a strategy for financing and disseminating interventions aimed at improving population health and health equity. The PFS approach has significant potential for bringing private-sector resources to interventions regarding social determinants of health. Nonetheless, a number of challenges remain, including structuring PFS initiatives so that optimal prevention benefits can be achieved and ensuring that PFS interventions and evaluation designs are based on rigorous research principles. In addition, increased policy attention regarding key PFS payout issues is needed, including the "wrong pockets" problem and legal barriers to using federal Medicaid funds as an investor payout source. Project HOPE—The People-to-People Health Foundation, Inc.

  16. Success Factors in Wind Power Projects; Factores de Exito en Proyectos de Energia Eolica

    Cabal Cuesta, H; Varela Conde, M; Lago Rodriguez, C; Saez Angulo, R M

    2002-07-01

    The Spanish wind energy market has experienced an average annual increase over 60% in recent years. With more than 4.1 GW of power at the end of 2002, this market has became the second in Europe and the third the world. With the objective of obtaining the origin of this success,an analysis of technical and economic features of selected wind projects has been undertaken to draw the outstanding factors that any new independent promoter/developer should take into account within this market. (Author) 16 refs.

  17. NASA Human Health and Performance Center: Open innovation successes and collaborative projects

    Richard, Elizabeth E.; Davis, Jeffrey R.

    2014-11-01

    In May 2007, what was then the Space Life Sciences Directorate published the 2007 Space Life Sciences Strategy for Human Space Exploration, setting the course for development and implementation of new business models and significant advances in external collaboration over the next five years. The strategy was updated on the basis of these accomplishments and reissued as the NASA Human Health and Performance Strategy in 2012, and continues to drive new approaches to innovation for the directorate. This short paper describes the successful execution of the strategy, driving organizational change through open innovation efforts and collaborative projects, including efforts of the NASA Human Health and Performance Center (NHHPC).

  18. Investment feasibility tracking: the importance of measuring and tracking the success level of the project during commercialization phase

    Saputra, Y. A.; Setyaningtyas, V. E. D.; Latiffianti, E.; Wijaya, S. H.; Ladamay, O. S. A.

    2018-04-01

    Measuring project success level is a challenging activity. This area of works has attracted many researchers to look deeper into the method of measurement, success factor identification, risk management, and many others relevant topics. However, the project management scope is limited until the project handover stage. After a project handover, the control of a project management changes from Project Management Team to the project owner/commercialization team. From an investor’s point of view, the success of a project delivery needs to be followed by the success of commercialization phase. This paper aims to present an approach on how we track and measure the progress and success level of a project investment in the commercialization phase. This is an interesting topic which probably often being forgotten in many practical case. Our proposed concept modify Freeman and Beale concept by estimating the variance between the Planned Net Present Value / Annual Worth (as it is in the Feasibility Study Document) and the Actual Net Present Value / Annual Worth (until the point time of evaluation). The gap will lead us to the next analysis and give us some important information, especially exposing whether our project investment performs better than the planning or underperformed. Some corrective actions can be suggested based on the provided information. Practical cases to exercise the concept is also provided and discussed; one case in a property sector in the middle of commercialization phase, and another case in a Power Plant investment approaching the end of commercialization phase.

  19. Enhanced regulatory sequence prediction using gapped k-mer features.

    Ghandi, Mahmoud; Lee, Dongwon; Mohammad-Noori, Morteza; Beer, Michael A

    2014-07-01

    Oligomers of length k, or k-mers, are convenient and widely used features for modeling the properties and functions of DNA and protein sequences. However, k-mers suffer from the inherent limitation that if the parameter k is increased to resolve longer features, the probability of observing any specific k-mer becomes very small, and k-mer counts approach a binary variable, with most k-mers absent and a few present once. Thus, any statistical learning approach using k-mers as features becomes susceptible to noisy training set k-mer frequencies once k becomes large. To address this problem, we introduce alternative feature sets using gapped k-mers, a new classifier, gkm-SVM, and a general method for robust estimation of k-mer frequencies. To make the method applicable to large-scale genome wide applications, we develop an efficient tree data structure for computing the kernel matrix. We show that compared to our original kmer-SVM and alternative approaches, our gkm-SVM predicts functional genomic regulatory elements and tissue specific enhancers with significantly improved accuracy, increasing the precision by up to a factor of two. We then show that gkm-SVM consistently outperforms kmer-SVM on human ENCODE ChIP-seq datasets, and further demonstrate the general utility of our method using a Naïve-Bayes classifier. Although developed for regulatory sequence analysis, these methods can be applied to any sequence classification problem.

  20. Enhanced regulatory sequence prediction using gapped k-mer features.

    Mahmoud Ghandi

    2014-07-01

    Full Text Available Oligomers of length k, or k-mers, are convenient and widely used features for modeling the properties and functions of DNA and protein sequences. However, k-mers suffer from the inherent limitation that if the parameter k is increased to resolve longer features, the probability of observing any specific k-mer becomes very small, and k-mer counts approach a binary variable, with most k-mers absent and a few present once. Thus, any statistical learning approach using k-mers as features becomes susceptible to noisy training set k-mer frequencies once k becomes large. To address this problem, we introduce alternative feature sets using gapped k-mers, a new classifier, gkm-SVM, and a general method for robust estimation of k-mer frequencies. To make the method applicable to large-scale genome wide applications, we develop an efficient tree data structure for computing the kernel matrix. We show that compared to our original kmer-SVM and alternative approaches, our gkm-SVM predicts functional genomic regulatory elements and tissue specific enhancers with significantly improved accuracy, increasing the precision by up to a factor of two. We then show that gkm-SVM consistently outperforms kmer-SVM on human ENCODE ChIP-seq datasets, and further demonstrate the general utility of our method using a Naïve-Bayes classifier. Although developed for regulatory sequence analysis, these methods can be applied to any sequence classification problem.

  1. An empirical study on the critical success factors of small to medium sized projects in a South African mining company

    Du Randt, Francois Jean

    2014-08-01

    Full Text Available Projects that fail, for whatever reason, can impact negatively on society, organisations, and other stakeholders. A number of researchers have identified various critical success factors (CSFs that can influence the outcome and success of a project. This research therefore aims to determine the CSFs that influence various success measures of small- to medium-sized projects at a South African mining company, Exxaro Resources’ Grootegeluk Coal Mine. Other objectives of this research include determining the extent of the impacts of these CSFs on the different success measures of a project. The investigation suggests that there are correlations among CSFs, and that certain factors impact the outcome of projects far more than others. This research finds that the single most important CSF for small- to medium-sized projects is the selection of a competent project manager. The competent project manager is characterised by a group of interrelated CSF factors: good leadership, commitment, and learning from past experiences. Based on the research results, other CSFs are discussed and explored in order for recommendations to be made on how this mining company, and possibly other organisations, can achieve greater project success.

  2. Chinese villages and their sustainable future: the European Union-China-Research Project "SUCCESS".

    Dumreicher, Heidi

    2008-04-01

    China has 800,000 villages-one person out of seven on the globe is living in a Chinese rural settlement. Yet the global discussions about the situation in China is currently characterised by a disproportionate focus on the development of towns and until now circumstances have generally been neglected in the rural areas, where 70% of the Chinese population is still living. Within the 5 years of the SUCCESS project research, this set of actual problems has been considered and analysed under the principle of sustainability: "What to maintain?" "What to change?" were the overall research questions asked in the SUCCESS project; the researchers were looking for answers under a sustainability regime, respecting the need to raise the quality of life in the villages. Several interweaving processes were used to achieve results: the inter-disciplinary research process between many areas of expertise, the trans-disciplinary process between the researchers and the Chinese villagers, and a negotiation process that made the connection between these two processes. The introduction describes the basic sustainability definition that was orienting the whole study. The innovation lays mostly in the methodology: the inter-disciplinary research co-operation related to practice and to involving the affected communities is needed to manage the significant and growing imbalances between urban and rural areas regarding their sustainability. In the transdisciplinary work, the project developed "village future sentences" that describe the local outcome of the research as one step towards better theoretical understanding of the mechanisms that could lead to a sustainable future, and they also managed to start sustainability processes in the case study sites. The integrated approach of the project helped generating future scenarios for these villages covering all aspects of their development, including urban design issues. Out of these scenarios, the villages developed small projects that could

  3. What is ′Successful Development′ in Conservation and Development Projects? Insights from Two Nicaraguan Case Studies

    Sandra K Znajda

    2014-01-01

    Full Text Available The lack of clear indications of success in integrated conservation and development projects has resulted in strong criticisms of these projects, and a call for the return to conservation activities that exclude local communities. Impeding this discussion is the lack of clarity around how project success is defined and measured in conservation and development projects, especially in terms of development goals. This study involved an in-depth exploration of two agroforestry-focused conservation and development projects in Nicaragua to provide insights into how success in reaching development goals is interpreted in such projects. In both projects, development was equated with increased household income, in contrast to more contemporary definitions that include aspects such as self-respect and social integration. Both projects in turn relied on income as a measure of development success, which ultimately lessened attention to impacts not easily measured quantitatively as well as participant perspectives on desired goals. The paper concludes with a discussion of implications for conservation practitioners; specifically the need for better alignment of project goals with contemporary explanations of development, and a need to move beyond primarily numerical indicators to measure change through an interdisciplinary approach in order to have a more comprehensive understanding of project impacts.

  4. Recapitulating phylogenies using k-mers: from trees to networks.

    Bernard, Guillaume; Ragan, Mark A; Chan, Cheong Xin

    2016-01-01

    Ernst Haeckel based his landmark Tree of Life on the supposed ontogenic recapitulation of phylogeny, i.e. that successive embryonic stages during the development of an organism re-trace the morphological forms of its ancestors over the course of evolution. Much of this idea has since been discredited. Today, phylogenies are often based on families of molecular sequences. The standard approach starts with a multiple sequence alignment, in which the sequences are arranged relative to each other in a way that maximises a measure of similarity position-by-position along their entire length. A tree (or sometimes a network) is then inferred. Rigorous multiple sequence alignment is computationally demanding, and evolutionary processes that shape the genomes of many microbes (bacteria, archaea and some morphologically simple eukaryotes) can add further complications. In particular, recombination, genome rearrangement and lateral genetic transfer undermine the assumptions that underlie multiple sequence alignment, and imply that a tree-like structure may be too simplistic. Here, using genome sequences of 143 bacterial and archaeal genomes, we construct a network of phylogenetic relatedness based on the number of shared k -mers (subsequences at fixed length k ). Our findings suggest that the network captures not only key aspects of microbial genome evolution as inferred from a tree, but also features that are not treelike. The method is highly scalable, allowing for investigation of genome evolution across a large number of genomes. Instead of using specific regions or sequences from genome sequences, or indeed Haeckel's idea of ontogeny, we argue that genome phylogenies can be inferred using k -mers from whole-genome sequences. Representing these networks dynamically allows biological questions of interest to be formulated and addressed quickly and in a visually intuitive manner.

  5. Small mammal community succession on the beach of Dongting Lake, China after the Three Gorges Project.

    Zhang, Meiwen; Wang, Yong; Li, Bo; Guo, Cong; Huang, Guoxian; Shen, Guo; Zhou, Xunjun

    2014-06-01

    Although the Three Gorges Project (TGP) may have affected the population structure and distribution of plant and animal communities, few studies have analyzed the effect of this project on small mammal communities. Therefore, the present paper compares the small mammal communities inhabiting the beaches of Dongting Lake using field investigations spanning a 20-year period, both before and after the TGP was implemented. Snap traps were used throughout the census. The results indicate that the TGP caused major changes to the structure of the small mammal community at a lake downstream of the dam. First, species abundance on the beaches increased after the project commenced. The striped field mouse (Apodemus agrarius) and the Norway rat (Rattus norvegicus), which rarely inhabited the beach before the TGP, became abundant (with marked population growth) once water was impounded by the Three Gorges Reservoir. Second, dominant species concentration indices exhibited a stepwise decline, indicating that the community structure changed from a single dominant species to a more diverse species mix after TGP implementation. Third, the regulation of water discharge release by the TGP might have caused an increase in the species diversity of the animal community on the beaches. A significant difference in diversity indices was obtained before and after the TGP operation. Similarity indices also indicate a gradual increase in species numbers. Hence, a long-term project should be established to monitor the population fluctuations of the Yangtze vole (Microtus fortis), the striped field mouse and the Norway rat to safeguard against population outbreaks (similar to the Yangtze vole outbreak in 2007), which could cause crop damage to adjacent farmland, in addition to documenting the succession process of the small mammal community inhabiting the beaches of Dongting Lake. © 2013 International Society of Zoological Sciences, Institute of Zoology/Chinese Academy of Sciences and Wiley

  6. Assessing IT Projects Success with Extended Fuzzy Cognitive Maps & Neutrosophic Cognitive Maps in comparison to Fuzzy Cognitive Maps

    Kanika Bhutani

    2016-08-01

    Full Text Available IT projects hold a huge importance to economic growth. Today, half of the capital investments are in IT technology. IT systems and projects are extensive and time consuming; thus implying that its failure is not affordable, so proper feasibility study of assessing project success factors is required. A current methodology like Fuzzy Cognitive Maps has been experimented for identifying and evaluating the success factors in IT projects, but this technique has certain limitations. This paper discusses two new approaches to evaluate IT project success: Extended Fuzzy Cognitive Maps (E-FCM & Neutrosophic Cognitive Maps (NCM.The limitations of FCM like non consideration for non-linear, conditional, time delay weights and indeterminate relations are targeted using E-FCM and NCM in this paper.

  7. Environmental Contamination and Viral Shedding in MERS Patients During MERS-CoV Outbreak in South Korea.

    Bin, Seo Yu; Heo, Jung Yeon; Song, Min-Suk; Lee, Jacob; Kim, Eun-Ha; Park, Su-Jin; Kwon, Hyeok-Il; Kim, Se Mi; Kim, Young-Il; Si, Young-Jae; Lee, In-Won; Baek, Yun Hee; Choi, Won-Suk; Min, Jinsoo; Jeong, Hye Won; Choi, Young Ki

    2016-03-15

    Although Middle East Respiratory Syndrome coronavirus (MERS-CoV) is characterized by a risk of nosocomial transmission, the detailed mode of transmission and period of virus shedding from infected patients are poorly understood. The aims of this study were to investigate the potential role of environmental contamination by MERS-CoV in healthcare settings and to define the period of viable virus shedding from MERS patients. We investigated environmental contamination from 4 patients in MERS-CoV units of 2 hospitals. MERS-CoV was detected by reverse transcription polymerase chain reaction (PCR) and viable virus was isolated by cultures. Many environmental surfaces of MERS patient rooms, including points frequently touched by patients or healthcare workers, were contaminated by MERS-CoV. Viral RNA was detected up to five days from environmental surfaces following the last positive PCR from patients' respiratory specimens. MERS-CoV RNA was detected in samples from anterooms, medical devices, and air-ventilating equipment. In addition, MERS-CoV was isolated from environmental objects such as bed sheets, bedrails, IV fluid hangers, and X-ray devices. During the late clinical phase of MERS, viable virus could be isolated in 3 of the 4 enrolled patients on day 18 to day 25 after symptom onset. Most of touchable surfaces in MERS units were contaminated by patients and health care workers and the viable virus could shed through respiratory secretion from clinically fully recovered patients. These results emphasize the need for strict environmental surface hygiene practices, and sufficient isolation period based on laboratory results rather than solely on clinical symptoms. © The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

  8. Extensive Viable Middle East Respiratory Syndrome (MERS) Coronavirus Contamination in Air and Surrounding Environment in MERS Isolation Wards.

    Kim, Sung-Han; Chang, So Young; Sung, Minki; Park, Ji Hoon; Bin Kim, Hong; Lee, Heeyoung; Choi, Jae-Phil; Choi, Won Suk; Min, Ji-Young

    2016-08-01

    The largest outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) outside the Middle East occurred in South Korea in 2015 and resulted in 186 laboratory-confirmed infections, including 36 (19%) deaths. Some hospitals were considered epicenters of infection and voluntarily shut down most of their operations after nearly half of all transmissions occurred in hospital settings. However, the ways that MERS-CoV is transmitted in healthcare settings are not well defined. We explored the possible contribution of contaminated hospital air and surfaces to MERS transmission by collecting air and swabbing environmental surfaces in 2 hospitals treating MERS-CoV patients. The samples were tested by viral culture with reverse transcription polymerase chain reaction (RT-PCR) and immunofluorescence assay (IFA) using MERS-CoV Spike antibody, and electron microscopy (EM). The presence of MERS-CoV was confirmed by RT-PCR of viral cultures of 4 of 7 air samples from 2 patients' rooms, 1 patient's restroom, and 1 common corridor. In addition, MERS-CoV was detected in 15 of 68 surface swabs by viral cultures. IFA on the cultures of the air and swab samples revealed the presence of MERS-CoV. EM images also revealed intact particles of MERS-CoV in viral cultures of the air and swab samples. These data provide experimental evidence for extensive viable MERS-CoV contamination of the air and surrounding materials in MERS outbreak units. Thus, our findings call for epidemiologic investigation of the possible scenarios for contact and airborne transmission, and raise concern regarding the adequacy of current infection control procedures. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

  9. Tissue Distribution of the MERS-Coronavirus Receptor in Bats

    W. Widagdo; L. Begeman (Lineke); D. Schipper (Debby); P.R.W.A. van Run (Peter); Cunningham, A.A. (Andrew A); Kley, N. (Nils); C.B.E.M. Reusken (Chantal); B.L. Haagmans (Bart); J.M.A. van den Brand (Judith)

    2017-01-01

    textabstractMiddle East respiratory syndrome coronavirus (MERS-CoV) has been shown to infect both humans and dromedary camels using dipeptidyl peptidase-4 (DPP4) as its receptor.The distribution of DPP4 in the respiratory tract tissues of humans and camels reflects MERS-CoV tropism.Apart from

  10. Tissue Distribution of the MERS-Coronavirus Receptor in Bats

    Widagdo, W; Begeman, Lineke; Schipper, Debby; van Run, Peter R; Cunningham, Andrew A; Kley, Nils; Reusken, Chantal B E M; Haagmans, Bart L; van den Brand, Judith M A

    2017-01-01

    Middle East respiratory syndrome coronavirus (MERS-CoV) has been shown to infect both humans and dromedary camels using dipeptidyl peptidase-4 (DPP4) as its receptor. The distribution of DPP4 in the respiratory tract tissues of humans and camels reflects MERS-CoV tropism. Apart from dromedary

  11. Deterministic and stochastic models for middle east respiratory syndrome (MERS)

    Suryani, Dessy Rizki; Zevika, Mona; Nuraini, Nuning

    2018-03-01

    World Health Organization (WHO) data stated that since September 2012, there were 1,733 cases of Middle East Respiratory Syndrome (MERS) with 628 death cases that occurred in 27 countries. MERS was first identified in Saudi Arabia in 2012 and the largest cases of MERS outside Saudi Arabia occurred in South Korea in 2015. MERS is a disease that attacks the respiratory system caused by infection of MERS-CoV. MERS-CoV transmission occurs directly through direct contact between infected individual with non-infected individual or indirectly through contaminated object by the free virus. Suspected, MERS can spread quickly because of the free virus in environment. Mathematical modeling is used to illustrate the transmission of MERS disease using deterministic model and stochastic model. Deterministic model is used to investigate the temporal dynamic from the system to analyze the steady state condition. Stochastic model approach using Continuous Time Markov Chain (CTMC) is used to predict the future states by using random variables. From the models that were built, the threshold value for deterministic models and stochastic models obtained in the same form and the probability of disease extinction can be computed by stochastic model. Simulations for both models using several of different parameters are shown, and the probability of disease extinction will be compared with several initial conditions.

  12. A Nursing Workforce Diversity Project: Strategies for Recruitment, Retention, Graduation, and NCLEX-RN Success.

    Murray, Ted A; Pole, David C; Ciarlo, Erica M; Holmes, Shearon

    2016-01-01

    The purpose of this article is to describe a collaborative project designed to recruit and retain students from underrepresented minorities and disadvantaged backgrounds into nursing education. Ethnic minorities remain underrepresented in the nursing workforce in comparison to the general population. The numbers of minorities enrolled in nursing education programs are insufficient to meet the health care workforce diversity needs of the future. High school students were provided with a preprofessional education program to prepare them for admission into a nursing program. Retention strategies were implemented for newly admitted and enrolled nursing education students. Twenty-one high school students enrolled in a nursing education program. The students enrolled in the nursing education program graduated and passed the licensure examination. Early recruitment and multiprong retention programs can be successful in diversifying the registered nurse workforce.

  13. NASA Human Health and Performance Center: Open Innovation Successes and Collaborative Projects

    Davis, Jeffrey R.; Richard, Elizabeth E.

    2014-01-01

    In May 2007, what was then the Space Life Sciences Directorate published the 2007 Space Life Sciences Strategy for Human Space Exploration, which resulted in the development and implementation of new business models and significant advances in external collaboration over the next five years. The strategy was updated on the basis of these accomplishments and reissued as the NASA Human Health and Performance Strategy in 2012, and continues to drive new approaches to innovation for the directorate. This short paper describes the open innovation successes and collaborative projects developed over this timeframe, including the efforts of the NASA Human Health and Performance Center (NHHPC), which was established to advance human health and performance innovations for spaceflight and societal benefit via collaboration in new markets.

  14. Statistically Consistent k-mer Methods for Phylogenetic Tree Reconstruction.

    Allman, Elizabeth S; Rhodes, John A; Sullivant, Seth

    2017-02-01

    Frequencies of k-mers in sequences are sometimes used as a basis for inferring phylogenetic trees without first obtaining a multiple sequence alignment. We show that a standard approach of using the squared Euclidean distance between k-mer vectors to approximate a tree metric can be statistically inconsistent. To remedy this, we derive model-based distance corrections for orthologous sequences without gaps, which lead to consistent tree inference. The identifiability of model parameters from k-mer frequencies is also studied. Finally, we report simulations showing that the corrected distance outperforms many other k-mer methods, even when sequences are generated with an insertion and deletion process. These results have implications for multiple sequence alignment as well since k-mer methods are usually the first step in constructing a guide tree for such algorithms.

  15. Successful completion of a RCRA closure for the Fernald Environmental Management Project

    Lippitt, J.M.; Kolthoff, K.

    1995-01-01

    This paper discusses the successful completion of a RCRA (Resource Conservation and Recovery Act) closure of a HF (hydrofluoric acid) tank car at FEMP, which is on the national priorities list of hazardous waste sites and is undergoing CERCLA remediation. The HF tank car closure was conducted by FERMCO. Through a combination of sound planning and team work, the HF tank car was closed safely and ahead of schedule. During > 22,000 hr field work required for construction modifications and neutralization of 9,600 gallons of HF and decontamination rinseates, there were no OSHA recordable incidents. The system design avoided additional costs by maximizing use of existing equipment and facilities. This successful closure of the HF tank car demonstrates FEMP's commitment to reducing risks and cleaning up the facility in a manner consistent with objectives of RCRA regulations and the Ohio EPA hazardous waste rules. This in turn facilitated ongoing negotiations with Ohio EPA to integrate RCRA closure and the ongoing CERCLA remediation activities. This paper addresses why the unit was clean closed under an approved RCRA Closure Plan. Integration of EPA regulations for RCRA and CERCLA programs and the DOE-Orders impacting design, construction and operation of an acid neutralization system is also reviewed. The paper concludes with a discussion of lessons learned in the process in preparing the closure plant and through final project close out

  16. Challenges in the Successful Research Management of a Collaborative EU Project.

    Zikos, Dimitrios; Diomidous, Marianna; Mantas, John

    2012-03-01

    Successful research management requirements include; equal teamwork and efficient coordination, in order to increase the impact of the research outcomes and provide added value knowledge. Aim of this paper is to discuss the strategies that have been followed during the RN4CAST study, the largest nursing multi-country research project ever conducted in Europe. The paper focuses on the core research strategies rather than on the administrative activities, which are inevitably also required for the success of a large scale research. This paper is an extension of a conference presentation in the International Conference of the European Federation for Medical Informatics (MIE) 2011 in Oslo, and was subsequently published in the Studies in Health Technology and Informatics book series (IOS Press) under the title "Research management: the case of RN4CAST." Management of a multicountry nursing survey requires the use of common data collection tools, applicable to every context, research protocols supporting the scope of the research, data models for multi-country analyses and global dissemination strategies. Challenges that may be faced during the implementation of the study include the individualized confrontation of obstacles during data collection, the coherence of national procedures (for example permissions for data collection) in European level, and the challenge to gain information of added value for the EU, by aggregating the national survey results through a powerful data analysis model. Communication strategies are also discussed.

  17. Common project energy change. The schedule to the success; Gemeinschaftsprojekt Energiewende. Der Fahrplan zum Erfolg

    Bartosch, Ulrich [Katholische Univ. Eichstaett-Ingolstadt (Germany).; VDW Vereinigung Deutscher Wissenschaftler, Berlin (Germany); Hennicke, Peter [Wuppertal Institut fuer Klima, Umwelt, Energie GmbH, Wuppertal (Germany); Weiger, Hubert (ed.) [Bund fuer Umwelt und Naturschutz Deutschland e.V. (BUND), Berlin (Germany)

    2014-07-01

    The energy change is the most important common work of the German after-war history. And it offers a unique collective field of learning, how the socio-ecological transformation can be converted in practice. If the energy change succeeds in an industrial country like Germany, many other countries can follow this example. The Bund fuer Umwelt und Naturschutz Deutschland (BUND) and the Vereinigung Deutscher Wissenschaftler (VDW) show as editors, what now must be done in order that the energy change becomes a success. Because currently threatens the energy change to be slowed down by the policy and talked to death by many stakeholders in the industry. This book demonstrates why the energy change is necessary and how it can succeed. It shows what has to be done and wants to use the existing enthusiasm in order to lead the common project energy change jointly to success. What is needed is a long-term policy that finally takes the reduction of energy consumption in attack.

  18. Rehabilitation of Sao Sebastiao-Cubatao oil pipeline: integrated planning and action - key for project success

    Serodio, Conrado J.M. [GDK S.A., Salvador, BA (Brazil)

    2009-12-19

    The execution of the OSBAT 24{sup o}il pipeline rehabilitation project, comprising the substitution of a 30 km section of the 37 years old pipeline has become a real benchmark in the history of this kind of job. The pipeline is inserted in one of the most sensitive environmental areas of the Sao Paulo State - the last Environmental Protection Area of the Mata Atlantica . The growth of human presence in its surroundings during the last three decades, has caused the right-of-way to be totally confined by luxury housing developments, streets, highways and resorts, as well as by the local communities and their activities, schools, and commerce. The pipeline runs through the Serra do Mar unstable mountain range slopes, with sequences of very steep hills and ravines followed by swamps and rivers. The success of such a challenging project - assembling the new line in a narrow ROW with all its restrictions, where the old line was still in operation, and complying with the tight work schedule required by PETROBRAS, was only possible due to a carefully managed combination of: accurate planning, best engineering methods and equipment and experienced workforce, deeply integrated in a massive effort towards safety, environmental care and social responsibility. (author)

  19. The project on site - setting the scene for successful industrial relations

    Morris, D.; Kershaw, A.R.

    1989-01-01

    The site construction performance at Torness and Heysham 2 has been described in various other papers during the Conference and in common with other large projects undertaken over the last 20 years a final judgement will be made as to whether, in simple terms, they were ''good'' or ''bad'' sites. Although there are many individuals or organisations who may make this judgement, it is unlikely that the basic conclusion will differ. What may differ however is the list of reasons that will be advanced to explain the final result. Looking at the investigations made into past projects, the reasons advanced for their success or otherwise can range from the geographical location of the site to material delivery problems, design changes, safety issues, or even the state of the overall national economic climate during the period under scrutiny. Where industrial relations problems are singled out, they can usually be linked to one or more of the factors mentioned. When looking at the complexity of projects such as Torness and Heysham, it is to be expected that unlooked for difficulties and problems will always arise but it is equally true that there is sufficient experience and expertise available in the industry for many possible problem areas to be anticipated and ''designed'' out before work even commences on site. This paper will be looking at the clients' role in creating a suitable environment for contractors to fully manage all aspects of their site operation and to ensure that acute problems can receive the full attention of all parties and not have to be set against a continuing background of unnecessary irritations. (author)

  20. IUE project comes to an end after 18+ years of extremely successful orbital operations

    1996-08-01

    At a meeting of the Science Programme Committee (SPC) of the European Space Agency (ESA) in February, the decision was taken to terminate the orbital operations of the International Ultraviolet Explorer (IUE) satellite on September 30. Science operations will terminate shortly before that date to allow the necessary end-of-life testing of the spacecraft. Only a year ago, when NASA - the major partner in the IUE project - decided to terminate its IUE science operations, ESA had been able to extend its support to include full responsibility for the scientific operations, under the "hybrid science operations" scheme, and thus maintain this important capability for the astrophysics community. As a consequence of the budgetary restrictions placed on ESA's Science Programme, the earlier recommendation of the Space Science Advisory Committee (SSAC), to terminate the operations of IUE in coordination with NASA in September, was accepted by the SPC. The IUE project, using a 45cm ultraviolet telescope for spectroscopic observations in the waveband 115 to 320 nm, has been carried out jointly by NASA, ESA and the British PPARC (formerly SERC). Launched in 1978, its designed lifetime was only three years. In July, the SPC agreed to complete the IUE Final Archive by the end of 1997, allowing the project to reprocess all its spectroscopic observations (numbering over 100,000) with a newly designed reduction, significantly improving on the normal direct processing done during the operational phase of the IUE project. The resulting homogeneous data archive on the ultraviolet radiation of cosmic sources, collected over the 18+ years of the operational project, will remain an important resource for astrophysical studies for many years to come. This has been one of the most successful astrophysics projects in space science, with more than 3,500 papers in refereed journals based on the observational results of the spectrographs. Over 500 doctoral dissertations have used its results

  1. Observations on the Morphology, Pollination and Cultivation of Coco de Mer (Lodoicea maldivica (J F Gmel. Pers., Palmae

    Stephen Blackmore

    2012-01-01

    Full Text Available We present a range of observations on the reproductive morphology, pollination biology and cultivation of Lodoicea maldivica (coco de mer, an endangered species with great ecological, economic and cultural importance. We review the history of study of this charismatic species. Morphological studies of the male inflorescence indicate its importance as a year-round food source to the Seychelles fauna. In situ observations suggest a number of potential biotic and abiotic pollination mechanisms including bees, flies, slugs, and geckos; trigonid bees are identified as the most likely potential natural pollinator. We outline a successful programme for ex situ pollination, germination, and cultivation of the coco de mer, highlighting the importance of temperature, humidity and light levels as well as maintaining an undisturbed environment. In combination with continued protection and monitoring, this advice may aid the future in situ and ex situ conservation of the coco de mer.

  2. Effect of disorder correlation in random mers

    Brezini, A.; Sebbani, M.; Depollier, C.; Belbachir, M.

    1995-12-01

    A widely held view in solid-state physics is that disorder precludes the presence of long-range transport in one-dimension. Recently a series of models has been proposed that do not conform to this view such as the well known Random Dimer Model (RDM). In the following paper, we must present a generalization of the RDM. In particular, the nature of the eigenstates of a non-interacting electron is investigated by means of a popular one-dimensional Kronig-Penney Hamiltonian in which n-mers have been placed at random on a regular lattice. Mainly in each allowed energy band of the spectrum, it is found that n-mers exhibits n - 1 resonances associated to extended states. Moreover these resonances appear to be narrower if the potential is attractive against repulsive, i.e. constituted of wells instead barriers, which discriminates the ability in localizing the eigenstates. Attention has been paid to the energy transition as one approaches the two resonances of the random trimer within the first allowed band. The transition exhibits a smooth behaviour for the lower energy when compared to the higher one with respect to the first resonance and shows quite a similar behaviour for both sides close to the second resonance. The discrepancy is attributed to the typical nature of the eigenstates for each resonance. Correspondingly, the wave functions associated to the first resonance are not like Bloch-waves while for the second one they look like the crystal wave functions displaying only minor distortions. (author). 44 refs, 6 figs

  3. Defensive behaviours in innovation teams: how project teams discuss defensiveness and its relationship with innovation resilience behaviour and project success

    Oeij, P.R.A.; Dhondt, S.; Gaspersz, J.B.R.; Vuuren, T. van

    2016-01-01

    Project team members and project leaders of innovation projects were interviewed about the possible presence of defensive behaviours within the team. While investigating defensive behaviour can be done validly by observation techniques, to talk about defensiveness within a team often leads to

  4. The Heidelberg Basin Drilling Project - Sedimentology and Stratigraphy of the Quaternary succession

    Ellwanger, Dietrich; Gabriel, Gerald; Hahne, Jürgen; Hoselmann, Christian; Menzies, John; Simon, Theo; Weidenfeller, Michael; Wielandt-Schuster, Ulrike

    2010-05-01

    Within the context of the Heidelberg Basin Drilling Project (Gabriel et al. 2008), a detailed sediment succession is presented here based upon deep drillings taken at Heidelberg UniNord and Mannheim Käfertal. Sediment structures, and micromorphological and pollen analyses were conducted and used to reconsider some of the climate transitions within the lower Pleistocene. A new and novel scenario is postulated regarding the preservation of Quaternary sediment packages within the Cenozoic Graben environment of the Heidelberg basin. The palynological evidence comprises the periods of warm climate of the Holsteinian (mainly Abies (fir), some Fagus (beech), Pterocarya & Azolla); the Cromerian (Pinus-Picea-QM (pine-spruce-QM)); the Bavelian (Abies, Tsuga (hemlock fir), QM & phases of increased NAP including Pinus); the Waalian (Abies, Tsuga, QM); and the Tiglian (Fagus & early Pleistocene taxa especially Sciadopytis, downward increasing Tertiary taxa). The sediment package was studied both macroscopically and microscopically. Both techniques provide evidence of fluvial, lacustrine and mass movement sedimentary processes. Some include evidence of periglacial processes (silt droplets within fine grained sands indicative of frozen ground conditions). The periglacial structures are often, not always, accompanied by pollen spectra dominated by pine and NAP. E.g. the Tiglian part of the succession shows periglacial sediment structures at its base and top but not in its middle sections. I.e. it appears not as a series of warm and cold phases but rather as a constant warm period with warm-cold-alternations at its bottom and top. All results illustrate sediment preservation in the Heidelberg basin almost throughout the Quaternary. This may be due to tectonic subsidence, but also to compaction by sediment loading of underlying fine sediments (Oligocene to Quaternary) leading to incomplete but virtually continuous sediment preservation (Tanner et al. 2009). References Gabriel, G

  5. The Evolution of Successful Satellite Science to Air Quality Application Projects: From Inception to Realization

    Soja, A. J.

    2012-12-01

    biomass burning portion of our nation's NEI at the crossroads of the applications 'largest cost-effective unknowns and uncertainties' and the 'best-available science and data'. Here, we will present a diagram tree of the completed evolution of a successful project, which includes the basic science on which this development is based and the succession of the use of satellite data within the applications and user communities.

  6. MERS transmission and risk factors: a systematic review.

    Park, Ji-Eun; Jung, Soyoung; Kim, Aeran; Park, Ji-Eun

    2018-05-02

    Since Middle East respiratory syndrome (MERS) infection was first reported in 2012, many studies have analysed its transmissibility and severity. However, the methodology and results of these studies have varied, and there has been no systematic review of MERS. This study reviews the characteristics and associated risk factors of MERS. We searched international (PubMed, ScienceDirect, Cochrane) and Korean databases (DBpia, KISS) for English- or Korean-language articles using the terms "MERS" and "Middle East respiratory syndrome". Only human studies with > 20 participants were analysed to exclude studies with low representation. Epidemiologic studies with information on transmissibility and severity of MERS as well as studies containing MERS risk factors were included. A total of 59 studies were included. Most studies from Saudi Arabia reported higher mortality (22-69.2%) than those from South Korea (20.4%). While the R 0 value in Saudi Arabia was < 1 in all but one study, in South Korea, the R 0 value was 2.5-8.09 in the early stage and decreased to < 1 in the later stage. The incubation period was 4.5-5.2 days in Saudi Arabia and 6-7.8 days in South Korea. Duration from onset was 4-10 days to confirmation, 2.9-5.3 days to hospitalization, 11-17 days to death, and 14-20 days to discharge. Older age and concomitant disease were the most common factors related to MERS infection, severity, and mortality. The transmissibility and severity of MERS differed by outbreak region and patient characteristics. Further studies assessing the risk of MERS should consider these factors.

  7. Monoclonal Antibody Shows Promise as Potential Therapeutic for MERS | Poster

    A monoclonal antibody has proven effective in preventing Middle Eastern Respiratory Syndrome (MERS) in lab animals, suggesting further development as a potential intervention for the deadly disease in humans, according to new research. MERS is a newly emerged coronavirus first detected in humans in 2012. Most cases have occurred in the Middle East, but the disease has appeared elsewhere. In all, MERS has infected more than 1,700 individuals and killed more than 600, according to the World Health Organization. No vaccines or antiviral therapies currently exist. Several candidate vaccines are being developed, and some have been tested in animal models, a prerequisite to human clinical trials.

  8. A consensus successive projections algorithm--multiple linear regression method for analyzing near infrared spectra.

    Liu, Ke; Chen, Xiaojing; Li, Limin; Chen, Huiling; Ruan, Xiukai; Liu, Wenbin

    2015-02-09

    The successive projections algorithm (SPA) is widely used to select variables for multiple linear regression (MLR) modeling. However, SPA used only once may not obtain all the useful information of the full spectra, because the number of selected variables cannot exceed the number of calibration samples in the SPA algorithm. Therefore, the SPA-MLR method risks the loss of useful information. To make a full use of the useful information in the spectra, a new method named "consensus SPA-MLR" (C-SPA-MLR) is proposed herein. This method is the combination of consensus strategy and SPA-MLR method. In the C-SPA-MLR method, SPA-MLR is used to construct member models with different subsets of variables, which are selected from the remaining variables iteratively. A consensus prediction is obtained by combining the predictions of the member models. The proposed method is evaluated by analyzing the near infrared (NIR) spectra of corn and diesel. The results of C-SPA-MLR method showed a better prediction performance compared with the SPA-MLR and full-spectra PLS methods. Moreover, these results could serve as a reference for combination the consensus strategy and other variable selection methods when analyzing NIR spectra and other spectroscopic techniques. Copyright © 2014 Elsevier B.V. All rights reserved.

  9. Successful projects subsidized by the ROB-programme; Succesvolle ROB-gesubsidieerde projecten

    NONE

    2010-03-15

    In the past years the Dutch program Reduction Other Greenhouse Gases (ROB) focused on the enhancement, development and implementation of measures aimed at reducing emissions of non-CO2 greenhouse gases. The main focus was directed to agriculture. Cooling and landfills. SenterNovem (currently named NL Agency) offered options for subsidies, knowledge and advice to start working on the reduction of non-CO2 greenhouse gases. A few examples of successful projects financed by ROB subsidy are briefly discussed. [Dutch] Het programma Reductie Overige Broeikasgassen (ROB) richtte zich de afgelopen jaren op het bevorderen, ontwikkelen en toepassen van maatregelen ter vermindering van de uitstoot van niet-CO2 broeikasgassen. De aandacht ging hierbij vooral uit naar de emissies van overige broeikasgassen afkomstig uit de landbouw, koeling en stortplaatsen. SenterNovem (nu het Agentschap NL) bood subsidiemogelijkheden, kennis en advies om met de reductie van niet-CO2 broeikasgassen aan de slag te gaan. Een paar voorbeelden van succesvolle projecten die met ROB-subsidies zijn gefinancierd worden in dit artikel kort besproken.

  10. An Ensemble Successive Project Algorithm for Liquor Detection Using Near Infrared Sensor.

    Qu, Fangfang; Ren, Dong; Wang, Jihua; Zhang, Zhong; Lu, Na; Meng, Lei

    2016-01-11

    Spectral analysis technique based on near infrared (NIR) sensor is a powerful tool for complex information processing and high precision recognition, and it has been widely applied to quality analysis and online inspection of agricultural products. This paper proposes a new method to address the instability of small sample sizes in the successive projections algorithm (SPA) as well as the lack of association between selected variables and the analyte. The proposed method is an evaluated bootstrap ensemble SPA method (EBSPA) based on a variable evaluation index (EI) for variable selection, and is applied to the quantitative prediction of alcohol concentrations in liquor using NIR sensor. In the experiment, the proposed EBSPA with three kinds of modeling methods are established to test their performance. In addition, the proposed EBSPA combined with partial least square is compared with other state-of-the-art variable selection methods. The results show that the proposed method can solve the defects of SPA and it has the best generalization performance and stability. Furthermore, the physical meaning of the selected variables from the near infrared sensor data is clear, which can effectively reduce the variables and improve their prediction accuracy.

  11. An Ensemble Successive Project Algorithm for Liquor Detection Using Near Infrared Sensor

    Fangfang Qu

    2016-01-01

    Full Text Available Spectral analysis technique based on near infrared (NIR sensor is a powerful tool for complex information processing and high precision recognition, and it has been widely applied to quality analysis and online inspection of agricultural products. This paper proposes a new method to address the instability of small sample sizes in the successive projections algorithm (SPA as well as the lack of association between selected variables and the analyte. The proposed method is an evaluated bootstrap ensemble SPA method (EBSPA based on a variable evaluation index (EI for variable selection, and is applied to the quantitative prediction of alcohol concentrations in liquor using NIR sensor. In the experiment, the proposed EBSPA with three kinds of modeling methods are established to test their performance. In addition, the proposed EBSPA combined with partial least square is compared with other state-of-the-art variable selection methods. The results show that the proposed method can solve the defects of SPA and it has the best generalization performance and stability. Furthermore, the physical meaning of the selected variables from the near infrared sensor data is clear, which can effectively reduce the variables and improve their prediction accuracy.

  12. Theoretical Approach Regarding the Bases of Success and Reasons that May Lead to Failure in Project Management

    Larisa Loredana Dragolea; Denisa Cotîrlea Denisa

    2012-01-01

    The present paper work deals with theoretical concepts regarding the reasons that may lead to a project’s failure or success. The primary aim of the work paper is to help readers to get a view of conceptualizations of project management and its phases, while providing an opportunity to see the interferences of factors that may determine project’s success. This work paper also contains some aspects regarding key-factors and elements that may assure a good management of projects. The present su...

  13. Developing a Mathematical Model for Scheduling and Determining Success Probability of Research Projects Considering Complex-Fuzzy Networks

    Gholamreza Norouzi

    2015-01-01

    Full Text Available In project management context, time management is one of the most important factors affecting project success. This paper proposes a new method to solve research project scheduling problems (RPSP containing Fuzzy Graphical Evaluation and Review Technique (FGERT networks. Through the deliverables of this method, a proper estimation of project completion time (PCT and success probability can be achieved. So algorithms were developed to cover all features of the problem based on three main parameters “duration, occurrence probability, and success probability.” These developed algorithms were known as PR-FGERT (Parallel and Reversible-Fuzzy GERT networks. The main provided framework includes simplifying the network of project and taking regular steps to determine PCT and success probability. Simplifications include (1 equivalent making of parallel and series branches in fuzzy network considering the concepts of probabilistic nodes, (2 equivalent making of delay or reversible-to-itself branches and impact of changing the parameters of time and probability based on removing related branches, (3 equivalent making of simple and complex loops, and (4 an algorithm that was provided to resolve no-loop fuzzy network, after equivalent making. Finally, the performance of models was compared with existing methods. The results showed proper and real performance of models in comparison with existing methods.

  14. EXTENDED CRITICAL SUCCESS FACTOR MODEL FOR MANAGEMENT OF MULTIPLE PROJECTS: AN EMPIRICAL VIEW FROM TRANSNET IN SOUTH AFRICA

    J.M. Nethathe

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: Transnet Freight Rail in South Africa has faced projects delays in its multi-project environment. This study takes South Africa as representative of developing countries, and develops the Critical Success Factors (CSFs model for multiple projects success, with the goal of expanding the conventional model by adding the demographic characteristics of the business units involved in the multiple projects. The empirical results showing the greatest number of success factors are people-related, with the focus on team selection and team commitment. Two demographic characteristics are of importance when managing multiple projects: the size of the business unit, and the employees’ project experience.

    AFRIKAANSE OPSOMMING: Transnet, ‘n spoorvragentiteit in Suid-Afrika, ondervind gereeld projekvertragings in hul multi-projekomgewing. Suid-Afrika, as ‘n voorbeeld van ontwikkelende lande, word in die studie gebruik en hierdie studie ontwikkel ‘n reeks suksesfaktore vir ‘n multi-projek-omgewing deur ‘n bestaande konvensionele model aan te pas om ook die demografiese eienskappe van die verskillende besigheidseenhede betrokke in die organisasie te inkorpo-reer. Die resultaat van die studie wys dat die grootste aantal suksesfaktore mens-geörienteerd is, met die fokus op die samestelling en toewyding van die betrokke projekspanne. Twee demografiese eienskape is belangrik by die bestuur van multi-projekte, naamlik die grootte van die besigheidseenheid asook projekondervinding van die werknemers.

  15. Ole Rømer som enevældens administrator

    Olden-Jørgensen, Sebastian

    2002-01-01

    En gennemgang af Ole Rømers liv med vægt på hans rolle som embedsmand og hans deltagelse eller mangel på samme i det politiske spil.......En gennemgang af Ole Rømers liv med vægt på hans rolle som embedsmand og hans deltagelse eller mangel på samme i det politiske spil....

  16. Cutoffs and k-mers: implications from a transcriptome study in allopolyploid plants

    Gruenheit Nicole

    2012-03-01

    Full Text Available Abstract Background Transcriptome analysis is increasingly being used to study the evolutionary origins and ecology of non-model plants. One issue for both transcriptome assembly and differential gene expression analyses is the common occurrence in plants of hybridisation and whole genome duplication (WGD and hybridization resulting in allopolyploidy. The divergence of duplicated genes following WGD creates near identical homeologues that can be problematic for de novo assembly and also reference based assembly protocols that use short reads (35 - 100 bp. Results Here we report a successful strategy for the assembly of two transcriptomes made using 75 bp Illumina reads from Pachycladon fastigiatum and Pachycladon cheesemanii. Both are allopolyploid plant species (2n = 20 that originated in the New Zealand Alps about 0.8 million years ago. In a systematic analysis of 19 different coverage cutoffs and 20 different k-mer sizes we showed that i none of the genes could be assembled across all of the parameter space ii assembly of each gene required an optimal set of parameter values and iii these parameter values could be explained in part by different gene expression levels and different degrees of similarity between genes. Conclusions To obtain optimal transcriptome assemblies for allopolyploid plants, k-mer size and k-mer coverage need to be considered simultaneously across a broad parameter space. This is important for assembling a maximum number of full length ESTs and for avoiding chimeric assemblies of homeologous and paralogous gene copies.

  17. Using MBTI for the Success Assessment of Engineering Teams in Project-Based Learning

    Rodríguez Montequín, V.; Mesa Fernández, J. M.; Balsera, J. Villanueva; García Nieto, A.

    2013-01-01

    Project-Based Learning (PBL) is a teaching and learning methodology that emphasizes student centered instruction by assigning projects. The students have to conduct significant projects and cope with realistic working conditions and scenarios. PBL is generally done by groups of students working together towards a common goal. Several factors play…

  18. Student ownership of projects in an upper-division optics laboratory course: A multiple case study of successful experiences

    Dimitri R. Dounas-Frazer

    2017-12-01

    Full Text Available We investigate students’ sense of ownership of multiweek final projects in an upper-division optics lab course. Using a multiple case study approach, we describe three student projects in detail. Within-case analyses focused on identifying key issues in each project, and constructing chronological descriptions of those events. Cross-case analysis focused on identifying emergent themes with respect to five dimensions of project ownership: student agency, instructor mentorship, peer collaboration, interest and value, and affective responses. Our within- and cross-case analyses yielded three major findings. First, coupling division of labor with collective brainstorming can help balance student agency, instructor mentorship, and peer collaboration. Second, students’ interest in the project and perceptions of its value can increase over time; initial student interest in the project topic is not a necessary condition for student ownership of the project. Third, student ownership is characterized by a wide range of emotions that fluctuate as students alternate between extended periods of struggle and moments of success while working on their projects. These findings not only extend the literature on student ownership into a new educational domain—namely, upper-division physics labs—they also have concrete implications for the design of experimental physics projects in courses for which student ownership is a desired learning outcome. We describe the course and projects in sufficient detail that others can adapt our results to their particular contexts.

  19. Student ownership of projects in an upper-division optics laboratory course: A multiple case study of successful experiences

    Dounas-Frazer, Dimitri R.; Stanley, Jacob T.; Lewandowski, H. J.

    2017-12-01

    We investigate students' sense of ownership of multiweek final projects in an upper-division optics lab course. Using a multiple case study approach, we describe three student projects in detail. Within-case analyses focused on identifying key issues in each project, and constructing chronological descriptions of those events. Cross-case analysis focused on identifying emergent themes with respect to five dimensions of project ownership: student agency, instructor mentorship, peer collaboration, interest and value, and affective responses. Our within- and cross-case analyses yielded three major findings. First, coupling division of labor with collective brainstorming can help balance student agency, instructor mentorship, and peer collaboration. Second, students' interest in the project and perceptions of its value can increase over time; initial student interest in the project topic is not a necessary condition for student ownership of the project. Third, student ownership is characterized by a wide range of emotions that fluctuate as students alternate between extended periods of struggle and moments of success while working on their projects. These findings not only extend the literature on student ownership into a new educational domain—namely, upper-division physics labs—they also have concrete implications for the design of experimental physics projects in courses for which student ownership is a desired learning outcome. We describe the course and projects in sufficient detail that others can adapt our results to their particular contexts.

  20. From Prime to Extended Mission: Evolution of the MER Tactical Uplink Process

    Mishkin, Andrew H.; Laubach, Sharon

    2006-01-01

    To support a 90-day surface mission for two robotic rovers, the Mars Exploration Rover mission designed and implemented an intensive tactical operations process, enabling daily commanding of each rover. Using a combination of new processes, custom software tools, a Mars-time staffing schedule, and seven-day-a-week operations, the MER team was able to compress the traditional weeks-long command-turnaround for a deep space robotic mission to about 18 hours. However, the pace of this process was never intended to be continued indefinitely. Even before the end of the three-month prime mission, MER operations began evolving towards greater sustainability. A combination of continued software tool development, increasing team experience, and availability of reusable sequences first reduced the mean process duration to approximately 11 hours. The number of workshifts required to perform the process dropped, and the team returned to a modified 'Earth-time' schedule. Additional process and tool adaptation eventually provided the option of planning multiple Martian days of activity within a single workshift, making 5-day-a-week operations possible. The vast majority of the science team returned to their home institutions, continuing to participate fully in the tactical operations process remotely. MER has continued to operate for over two Earth-years as many of its key personnel have moved on to other projects, the operations team and budget have shrunk, and the rovers have begun to exhibit symptoms of aging.

  1. MANAGEMENT OF TRANSURANIC (TRU) WASTE RETRIEVAL PROJECT RISKS SUCCESSES IN THE STARTUP OF THE HANFORD 200 AREA TRU WASTE RETRIEVAL PROJECT

    GREENWLL, R.D.

    2005-01-01

    A risk identification and mitigation method applied to the Transuranic (TRU) Waste Retrieval Project performed at the Hanford 200 Area burial grounds is described. Retrieval operations are analyzed using process flow diagramming. and the anticipated project contingencies are included in the Authorization Basis and operational plans. Examples of uncertainties assessed include degraded container integrity, bulged drums, unknown containers, and releases to the environment. Identification and mitigation of project risks contributed to the safe retrieval of over 1700 cubic meters of waste without significant work stoppage and below the targeted cost per cubic meter retrieved. This paper will be of interest to managers, project engineers, regulators, and others who are responsible for successful performance of waste retrieval and other projects with high safety and performance risks

  2. Project Management Meets Change Management - A Success Story. Focus Area: Tech Perspectives TI012SN

    Hall, Wayne

    2011-01-01

    Utilizing the concepts and terminology from Project Management, the process of planning and executing a Change Management (CM) Infrastructure improvement project is described. The primary audience for this presentation includes both experienced and relatively new CM administrators and their managers. It also includes anyone with an interest in the application of project management knowledge to CM administration. There are several benefits: the complexity of the CM tool technology is more manageable, CM administrators get to use project management knowledge to complete a project (not "firefighting"), improve relations with your customers (that means developers and managers), and get the opportunity to do it again.

  3. Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: incidence and risk factors of MERS-CoV seropositivity.

    Kim, C-J; Choi, W S; Jung, Y; Kiem, S; Seol, H Y; Woo, H J; Choi, Y H; Son, J S; Kim, K-H; Kim, Y-S; Kim, E S; Park, S H; Yoon, J H; Choi, S-M; Lee, H; Oh, W S; Choi, S-Y; Kim, N-J; Choi, J-P; Park, S Y; Kim, J; Jeong, S J; Lee, K S; Jang, H C; Rhee, J Y; Kim, B-N; Bang, J H; Lee, J H; Park, S; Kim, H Y; Choi, J K; Wi, Y-M; Choi, H J

    2016-10-01

    Given the mode of transmission of Middle East respiratory syndrome (MERS), healthcare workers (HCWs) in contact with MERS patients are expected to be at risk of MERS infections. We evaluated the prevalence of MERS coronavirus (CoV) immunoglobulin (Ig) G in HCWs exposed to MERS patients and calculated the incidence of MERS-affected cases in HCWs. We enrolled HCWs from hospitals where confirmed MERS patients had visited. Serum was collected 4 to 6 weeks after the last contact with a confirmed MERS patient. We performed an enzyme-linked immunosorbent assay (ELISA) to screen for the presence of MERS-CoV IgG and an indirect immunofluorescence test (IIFT) to confirm MERS-CoV IgG. We used a questionnaire to collect information regarding the exposure. We calculated the incidence of MERS-affected cases by dividing the sum of PCR-confirmed and serology-confirmed cases by the number of exposed HCWs in participating hospitals. In total, 1169 HCWs in 31 hospitals had contact with 114 MERS patients, and among the HCWs, 15 were PCR-confirmed MERS cases in study hospitals. Serologic analysis was performed for 737 participants. ELISA was positive in five participants and borderline for seven. IIFT was positive for two (0.3%) of these 12 participants. Among the participants who did not use appropriate personal protective equipment (PPE), seropositivity was 0.7% (2/294) compared to 0% (0/443) in cases with appropriate PPE use. The incidence of MERS infection in HCWs was 1.5% (17/1169). The seroprevalence of MERS-CoV IgG among HCWs was higher among participants who did not use appropriate PPE. Copyright © 2016. Published by Elsevier Ltd.

  4. A learning-based approach to understanding success in rural electrification : insights from micro hydro projects in Bolivia

    Drinkwaard, ir. W.; Kirkels, A.F.; Romijn, H.A.

    2010-01-01

    The paper analyzes the performance of a set of rural Micro Hydro Power (MHP) projects and MHP-implementing organizations in Bolivia, using a learning-based analytical perspective. Rather than identifying a generic set of critical success factors such as access to finance, adequate technological

  5. Using Geomorphic Change Detection to Understand Restoration Project Success Relative to Stream Size

    Yeager, A.; Segura, C.

    2017-12-01

    Large wood (LW) jams have long been utilized as a stream restoration strategy to create fish habitat, with a strong focus on Coho salmon in the Pacific Northwest. These projects continue to be implemented despite limited understanding of their success in streams of different size. In this study, we assessed the changes triggered by LW introductions in 10 alluvial plane bed reaches with varying drainage areas (3.9-22 km²) and bankfull widths (6.4-14.7 m) in one Oregon Coast Range basin. In this basin, LW was added in an effort to improve winter rearing habitat for Coho salmon. We used detailed topographic mapping (0.5 m² resolution) to describe the local stream and floodplain geometry. Pebble counts were used to monitor changes in average substrate size after the LW addition. Field surveys were conducted immediately after the LW were installed, in the summer of 2016, and one year after installation, in the summer of 2017. We used geomorphic change detection analysis to quantify the amount of scour and deposition at each site along with changes in average bankfull width. Then we determined the relative amount of change among all sites to identify which size stream changed the most. We also modeled fluctuations in water surface elevation at each site, correlating frequency and inundation of the LW with geomorphic changes detected from the topographic surveys. Preliminary results show an increase in channel width and floodplain connectivity at all sites, indicating an increase in off-channel habitat for juvenile Coho salmon. Bankfull widths increased up to 75% in small sites and up to 25% in large sites. Median grain size became coarser in large streams (increased up to 20%), while we saw a similar amount of fining at smaller sites. The overall increase in channel width is compensated by an overall decrease in bed elevation at both large and small sites, suggesting the maintenance of overall geomorphic equilibrium. Further work will include quantifying these

  6. Opportunity, risk, and success recognizing, addressing, and balancing multiple factors crucial to the success of a project management system deployed to support multi-lateral decommissioning programs

    Funk, Greg; Longsworth, Paul

    2007-01-01

    This paper addresses the factors involved in effectively implementing a world-class program/project management information system funded by multiple nations. Along with many other benefits, investing in and utilizing such systems improves delivery and drive accountability for major expenditures. However, there are an equally large number of impediments to developing and using such systems. To be successful, the process requires a dynamic combining of elements and strategic sequencing of initiatives. While program/project-management systems involve information technologies, software and hardware, they represent only one element of the overall system.. Technology, process, people and knowledge must all be integrated and working in concert with one another to assure a fully capable system. Major system implementations occur infrequently, and frequently miss established targets in relatively small organizations (with the risk increasing with greater complexity). The European Bank of Reconstruction (EBRD) is midway through just such an implementation. The EBRD is using funds from numerous donor countries to sponsor development of an overarching program management system. The system will provide the Russian Federation with the tools to effectively manage prioritizing, planning, and physically decommissioning assets i n northwest Russia to mitigate risks associated the Soviet era nuclear submarine program. Project-management delivery using world-class techniques supported by aligned systems has been proven to increase the probability of delivering on-time and on-budget, assuring those funding such programs optimum value for money. However, systems deployed to manage multi-laterally funded projects must be developed with appropriate levels of consideration given to unique aspects such as: accommodation of existing project management methods, consideration for differences is management structures and organizational behaviors, incorporation of unique strengths, and subtle

  7. Using Critical Thinking Teaching Methods to Increase Student Success: An Action Research Project

    Nold, Herbert

    2017-01-01

    Numerous studies and United States Department of Education reports indicate that university graduates lack critical thinking and problem solving skills that are needed for success in both the classroom and the modern workplace. Success in the classroom and workplace is a function of many attributes that change with the situation, but the ability…

  8. Successes and challenges of north-south partnerships - key lessons from the African/Asian Regional Capacity Development projects.

    Färnman, Rosanna; Diwan, Vishal; Zwarenstein, Merrick; Atkins, Salla

    2016-01-01

    Increasing efforts are being made globally on capacity building. North-south research partnerships have contributed significantly to enhancing the research capacity in low- and middle-income countries (LMICs) over the past few decades; however, a lack of skilled researchers to inform health policy development persists, particularly in LMICs. The EU FP7 funded African/Asian Regional Capacity Development (ARCADE) projects were multi-partner consortia aimed to develop a new generation of highly trained researchers from universities across the globe, focusing on global health-related subjects: health systems and services research and research on social determinants of health. This article aims to outline the successes, challenges and lessons learned from the life course of the projects, focusing on the key outputs and experiences of developing and implementing these two projects together with sub-Saharan African, Asian and European institution partners. Sixteen participants from 12 partner institutions were interviewed. The data were analysed using thematic content analysis, which resulted in four themes and three sub-categories. These data were complemented by a review of project reports. The results indicated that the ARCADE projects have been successful in developing and delivering courses, and have reached over 920 postgraduate students. Some partners thought the north-south and south-south partnerships that evolved during the project were the main achievement. However, others found there to be a 'north-south divide' in certain aspects. Challenges included technical constraints and quality assurance. Additionally, adapting new teaching and learning methods into current university systems was challenging, combined with not being able to award students with credits for their degrees. The ARCADE projects were introduced as an innovative and ambitious project idea, although not designed appropriately for all partner institutions. Some challenges were underestimated

  9. Successes and challenges of north–south partnerships – key lessons from the African/Asian Regional Capacity Development projects

    Färnman, Rosanna; Diwan, Vishal; Zwarenstein, Merrick; Atkins, Salla

    2016-01-01

    Introduction Increasing efforts are being made globally on capacity building. North–south research partnerships have contributed significantly to enhancing the research capacity in low- and middle-income countries (LMICs) over the past few decades; however, a lack of skilled researchers to inform health policy development persists, particularly in LMICs. The EU FP7 funded African/Asian Regional Capacity Development (ARCADE) projects were multi-partner consortia aimed to develop a new generation of highly trained researchers from universities across the globe, focusing on global health-related subjects: health systems and services research and research on social determinants of health. This article aims to outline the successes, challenges and lessons learned from the life course of the projects, focusing on the key outputs and experiences of developing and implementing these two projects together with sub-Saharan African, Asian and European institution partners. Design Sixteen participants from 12 partner institutions were interviewed. The data were analysed using thematic content analysis, which resulted in four themes and three sub-categories. These data were complemented by a review of project reports. Results The results indicated that the ARCADE projects have been successful in developing and delivering courses, and have reached over 920 postgraduate students. Some partners thought the north–south and south–south partnerships that evolved during the project were the main achievement. However, others found there to be a ‘north–south divide’ in certain aspects. Challenges included technical constraints and quality assurance. Additionally, adapting new teaching and learning methods into current university systems was challenging, combined with not being able to award students with credits for their degrees. Conclusion The ARCADE projects were introduced as an innovative and ambitious project idea, although not designed appropriately for all partner

  10. Statistics in Action: The Story of a Successful Service-Learning Project

    DeHart, Mary; Ham, Jim

    2011-01-01

    The purpose of this article is to share the stories of an Introductory Statistics service-learning project in which students from both New Jersey and Michigan design and conduct phone surveys that lead to publication in local newspapers; to discuss the pedagogical benefits and challenges of the project; and to provide information for those who…

  11. Citizen science participation in research in the environmental sciences: key factors related to projects' success and longevity.

    Cunha, Davi G F; Marques, Jonatas F; Resende, Juliana C DE; Falco, Patrícia B DE; Souza, Chrislaine M DE; Loiselle, Steven A

    2017-01-01

    The potential impacts of citizen science initiatives are increasing across the globe, albeit in an imbalanced manner. In general, there is a strong element of trial and error in most projects, and the comparison of best practices and project structure between different initiatives remains difficult. In Brazil, the participation of volunteers in environmental research is limited. Identifying the factors related to citizen science projects' success and longevity within a global perspective can contribute for consolidating such practices in the country. In this study, we explore past and present projects, including a case study in Brazil, to identify the spatial and temporal trends of citizen science programs as well as their best practices and challenges. We performed a bibliographic search using Google Scholar and considered results from 2005-2014. Although these results are subjective due to the Google Scholar's algorithm and ranking criteria, we highlighted factors to compare projects across geographical and disciplinary areas and identified key matches between project proponents and participants, project goals and local priorities, participant profiles and engagement, scientific methods and funding. This approach is a useful starting point for future citizen science projects, allowing for a systematic analysis of potential inconsistencies and shortcomings in this emerging field.

  12. [Health projects managed by Nursing Coordinators: an analysis of contents and degree of success].

    Palese, Alvisa; Bresciani, Federica; Brutti, Caterina; Chiari, Ileana; Fontana, Luciana; Fronza, Ornella; Gasperi, Giuseppina; Gheno, Oscar; Guarese, Olga; Leali, Anna; Mansueti, Nadia; Masieri, Enrico; Messina, Laura; Munaretto, Gabriella; Paoli, Claudia; Perusi, Chiara; Randon, Giulia; Rossi, Gloria; Solazzo, Pasquale; Telli, Debora; Trenti, Giuliano; Veronese, Elisabetta; Saiani, Luisa

    2012-01-01

    To describe the evolution and results of health projects run in hospitals and managed by Nursing Coordinators. A convenience sample of 13 north Italian hospital, and a sample of 56 Nursing Coordinators with a permanent position from at least 1 year, was contacted. The following information was collected with a structured interview: projects run in 2009, topic, if bottom up or top down, number of staff involved and state (ended, still running, stopped). In 2009 Nursing Coordinators started 114 projects (mean 1.8±1.2 each): 94 (82.5%) were improvement projects, 17 (14.9%) accreditation, and 3 (2.6%) research. The projects involved 2.732 staff members (73.7%; average commitment 84 hours); 55 (48.2%) projects were still running, 52 (45.6%) completed, for 5 (4.4%) there was no assessment and 2 (1.8%) had been stopped. Nurses are regularly involved in several projects. A systematic monitoring of the results obtained and stabilization strategies are scarce. Due to the large number of resources invested, a correct management and the choice of areas relevant for patients' problems and needs are pivotal.

  13. Public project success as seen in a broad perspective.: Lessons from a meta-evaluation of 20 infrastructure projects in Norway.

    Volden, Gro Holst

    2018-08-01

    Infrastructure projects in developed countries are rarely evaluated ex-post. Despite their number and scope, our knowledge about their various impacts is surprisingly limited. The paper argues that such projects must be assessed in a broad perspective that includes both operational, tactical and strategic aspects, and unintended as well as intended effects. A generic six-criteria evaluation framework is suggested, inspired by a framework frequently used to evaluate development assistance projects. It is tested on 20 Norwegian projects from various sectors (transport, defence, ICT, buildings). The results indicate that the majority of projects were successful, especially in operational terms, possibly because they underwent external quality assurance up-front. It is argued that applying this type of standardized framework provides a good basis for comparison and learning across sectors. It is suggested that evaluations should be conducted with the aim of promoting accountability, building knowledge about infrastructure projects, and continuously improve the tools, methods and governance arrangements used in the front-end of project development. Copyright © 2018 The Author. Published by Elsevier Ltd.. All rights reserved.

  14. Some successful financing mechanisms for energy efficiency projects (EE) and projects using renewable energy sources (RES) - the experience of Bulgaria

    Uzunova, Boriana

    2004-01-01

    The paper analysis some of the most promising financial mechanisms for energy efficiency (EE) and renewable energy sources (RES) projects in Bulgaria - the TPF mechanism, the KIDS Fund, delivered by the EBRD fund the EE fund of the WB, established on the floor of the EE act, as well as a number of some of the pre accession and European energy programs used for financing this area. All data its rich intensive international and in -home work in the are of energy efficiency and renewable energy sources. (Author)

  15. Synthesis of the project leadership staffing needs for successful development of alternative delivery programs.

    2017-08-01

    This research provides a synthesis of practices in organizational structuring and professional staffing of the innovative delivery units in several state DOTs across the nation that are actively utilizing alternative project delivery. Several major c...

  16. Examples of Department of Energy Successes for Remediation of Contaminated Groundwater: Permeable Reactive Barrier and Dynamic Underground Stripping ASTD Projects

    Purdy, C.; Gerdes, K.; Aljayoushi, J.; Kaback, D.; Ivory, T.

    2002-01-01

    Since 1998, the Department of Energy's (DOE) Office of Environmental Management has funded the Accelerated Site Technology Deployment (ASTD) Program to expedite deployment of alternative technologies that can save time and money for the environmental cleanup at DOE sites across the nation. The ASTD program has accelerated more than one hundred deployments of new technologies under 76 projects that focus on a broad spectrum of EM problems. More than 25 environmental restoration projects have been initiated to solve the following types of problems: characterization of the subsurface using chemical, radiological, geophysical, and statistical methods; treatment of groundwater contaminated with DNAPLs, metals, or radionuclides; and other projects such as landfill covers, purge water management systems, and treatment of explosives-contaminated soils. One of the major goals of the ASTD Program is to deploy a new technology or process at multiple DOE sites. ASTD projects are encouraged to identify subsequent deployments at other sites. Some of the projects that have successfully deployed technologies at multiple sites focusing on cleanup of contaminated groundwater include: Permeable Reactive Barriers (Monticello, Rocky Flats, and Kansas City), treating uranium and organics in groundwater; and Dynamic Underground Stripping (Portsmouth, and Savannah River), thermally treating DNAPL source zones. Each year more and more new technologies and approaches are being used at DOE sites due to the ASTD program. DOE sites are sharing their successes and communicating lessons learned so that the new technologies can replace the baseline or standard approaches at DOE sites, thus expediting cleanup and saving money

  17. Designing a lessons learned model to improve the success of new product development in project oriented organizations

    Ahmad

    2016-12-01

    Full Text Available Nowadays, project-based organizations need to utilize intellectual capital and knowledge to become leader in their business activities. The new approach to use knowledge based skills from one side and development of the new complicated products from the other side have increased the need for designing a lessons learned model. The purpose of this paper is to design a lessons learned model to improve the success of new product development for project oriented organizations. The study designs a questionnaire in Likert scale and distributes it among 56 experts who were well informed about various techniques of new product development and lessons learned. Cronbach alphas for all components of the survey were well above the desirable level. The results of the survey have indicated that there were positive and meaningful relationships between lessons learned components and the success of the new product development.

  18. Chernobyl risk reduction via ventilation stack repair: a successful international project

    Gore, B.F.; Glukhov, A.Y.; Schmidt, J.P.; Vargo, G.I.; Osterloh, J.V.; Kupny, V.I.; Korneev, A.A.; Matvejev, Y.A.

    1999-01-01

    The recently completed project to repair the ChNPP Unit 3/4 ventilation stack is the first international project providing a direct physical improvement and safety upgrade at the Shelter (Ukrytie) facility. The 1986 explosion at Chernobyl NPP Unit 4 severely damaged the ventilation stack framework of bracing and its foundation. At one node, where six elements of the framework joined together, one element was completely missing one element was torn from the node and left hanging from its other end, and one element was badly bent and dented. Foundation supports were knocked measurably off plumb. Repair of the ChNPP ventilation stack is the first international project providing direct physical improvement and safety upgrade at the Shelter facility. The repairs have restored the stack to full design strength, from an emergency condition with a high probability of collapse

  19. Environmental awareness - a spinoff success of public awareness outreach around Kudankulam Nuclear Power Project

    Jashi, K.B.; Sathish, A.V.; Vijayakumar, B.; Pandaram, P.; Kalirajan, S.

    2014-01-01

    The significance of public awareness (PA) programme at Kudankulam Nuclear Power Project (KKNPP) was well recognised since the inception stage itself and several PA programme were organised around Kudankulam through different means of communication. In its chequered progress, the Kudankulam project has seen ups and downs from the initial stage and in the year 2011, the site witnessed an impasse due to public interest and concerns on nuclear projects. Subsequently PA programmes were taken up on a war footing with persistent efforts, public fear on nuclear energy and safety concerns were allayed among local public in the villages in and around Kudankulam and also far and wide in Tamil Nadu and Kerala. This paper discusses the various measures initiated to disseminate the right information and educating public on nuclear energy as a clean energy option for environmental safety. In addition, it is a requirement of the country in the face of impending climate change concerns and warming of the earth's surface

  20. Analyzing the Watershed Dynamics project as an example of successful science and education partnerships

    Buzby, C. K.; Jona, K.

    2009-12-01

    The Watershed Dynamics project is a partnership between Northwestern University, the Consortium of Universities for the Advancement of Hydrologic Science (CUAHSI), and the GLOBE Program (Global Learning and Observations to Benefit the Environment). The goal of the project is to develop inquiry-based educational materials that use authentic scientific data and analysis techniques to teach students about the watershed. The relationship between Northwestern, CUAHSI, and GLOBE allows each partner to contribute to the development of the project in the area of their expertise. Science researchers from CUAHSI share science content knowledge and data access through the development of their Hydrologic Information System (HIS). Curriculum developers at Northwestern write inquiry-based curriculum using GIS technology to access and analyze live data. The GLOBE Program is a worldwide hands-on, primary and secondary school-based science education program that provides teacher training opportunities to a network of teachers around the world. This partnership allows each partner to bring their area of expertise to the project and make the best use of one another's resources. The Watershed Dynamics project can serve as a model for future partnerships between the science and education communities. The Office of Science, Technology, Engineering, and Math Education Partnerships (OSEP) at Northwestern is a service organization that supports Northwestern researchers in developing proposals and implementing research projects that incorporate K-12 educational components, particularly in the fields of science, technology, engineering and mathematics (STEM). OSEP assists faculty with the development of sound plans for education and outreach that reflect current research on learning and educational reform and provides expertise in STEM education materials development, learning technologies, and professional development for K-12 teachers and facilitators in informal education institutions

  1. A Path to Successful Energy Retrofits: Early Collaboration through Integrated Project Delivery Teams

    Parrish, Kristen [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2012-10-01

    This document guides you through a process for the early design phases of retrofit projects to help you mitigate frustrations commonly experienced by building owners and designers. It outlines the value of forming an integrated project delivery team and developing a communication and information-sharing infrastructure that fosters collaboration. This guide does not present a complete process for designing an energy retrofit for a building. Instead, it focuses on the early design phase tasks related to developing and selecting energy efficiency measures (EEMs) that benefit from collaboration, and highlights the resulting advantages.

  2. Determinants for Failure and Success of Innovation Projects: The Road to Sustainable Educational Innovation

    Kirschner, P. A.; Hendricks, M.; Paas, F.; Wopereis, I.; Cordewener, B.

    2004-01-01

    Robert Burns wrote: "The best laid schemes of Mice and Men oft go awry". This could be considered the motto of most educational innovation. The question that arises is not so much why some innovations fail (although this is very important question), but rather why other innovations succeed? This study investigated the success factors of…

  3. Examining Career Success of Minority and Women Emergency Medical Technicians (EMTs): A LEADS Project

    Russ-Eft, Darlene F.; Dickison, Philip D.; Levine, Roger

    2008-01-01

    Emergency medical technicians (EMTs) are a critical segment in prehospital medical care. This study examined EMT-paramedic career success focused on minorities and women, as part of the Longitudinal Emergency Medical Technician Attributes and Demographics Study (LEADS). The LEADS data come from a representative sampling of EMTs throughout the…

  4. Manager Perspectives on Communication and Public Engagement in Ecological Restoration Project Success

    We argue that public engagement is crucial to achieving lasting ecological success in aquatic restoration efforts, and that the most effective public engagement mechanisms are what we term iterative mechanisms. Here we look to a particular social-ecological system – the restorati...

  5. The clinical and virological features of the first imported case causing MERS-CoV outbreak in South Korea, 2015.

    Lee, Ji Yeon; Kim, You-Jin; Chung, Eun Hee; Kim, Dae-Won; Jeong, Ina; Kim, Yeonjae; Yun, Mi-Ran; Kim, Sung Soon; Kim, Gayeon; Joh, Joon-Sung

    2017-07-14

    In 2015, the largest outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection outside the Middle East occurred in South Korea. We summarized the epidemiological, clinical, and laboratory findings of the first Korean case of MERS-CoV and analyzed whole-genome sequences of MERS-CoV derived from the patient. A 68-year-old man developed fever and myalgia 7 days after returning to Korea, following a 10-day trip to the Middle East. Before diagnosis, he visited 4 hospitals, potentially resulting in secondary transmission to 28 patients. On admission to the National Medical Center (day 9, post-onset of clinical illness), he presented with drowsiness, hypoxia, and multiple patchy infiltrations on the chest radiograph. He was intubated (day 12) because of progressive acute respiratory distress syndrome (ARDS) and INF-α2a and ribavirin treatment was commenced. The treatment course was prolonged by superimposed ventilator associated pneumonia. MERS-CoV PCR results converted to negative from day 47 and the patient was discharged (day 137), following rehabilitation therapy. The complete genome sequence obtained from a sputum sample (taken on day 11) showed the highest sequence similarity (99.59%) with the virus from an outbreak in Riyadh, Saudi Arabia, in February 2015. The first case of MERS-CoV infection had high transmissibility and was associated with a severe clinical course. The patient made a successful recovery after early treatment with antiviral agents and adequate supportive care. This first case in South Korea became a super-spreader because of improper infection control measures, rather than variations of the virus.

  6. Success factors in the realization of large ice projects in education

    Pronk, A.D.C.; Luo, P.; Li, Q.; Sanders, F.; Overtoom, M.; Coar, L.; Bogle, Annette; Grohmann, Manfred

    2017-01-01

    There has been a long tradition in making ice structures, but the development of technical improvements for making ice buildings is a new field with just a handful of researchers. Most of the projects were realized by professors in cooperation with their students as part of their education in

  7. Evaluating the ecological economic success of riparian restoration projects in Arizona (Abstract)

    Gary B. Snider

    2000-01-01

    The past 4 years the Arizona Water Protection Fund provided more than $25 million to individuals and organizations for stream and riparian restoration projects in Arizona. Information which increases the awareness of the value of Arizona's riparian systems is crucial to the incorporation of ecosystem services into decision-making frameworks, which are largely...

  8. Ole Rømer som enevældens administrator

    Olden-Jørgensen, Sebastian

    2004-01-01

    En biografisk skitse af Ole Rømers virke med vægt på hans rolle som embedsmand og rådgiver for Christian V. Hans virke analyseres på baggrund af en ny forståelse for den tidlige enevældes politiske kultur.......En biografisk skitse af Ole Rømers virke med vægt på hans rolle som embedsmand og rådgiver for Christian V. Hans virke analyseres på baggrund af en ny forståelse for den tidlige enevældes politiske kultur....

  9. The Norwegian Plasma Fractionation Project--a 12 year clinical and economic success story.

    Flesland, O; Seghatchian, J; Solheim, B G

    2003-02-01

    The establishment of the Norwegian Fractionation Project (Project) was of major importance in preserving national self-sufficiency when plasma, cryoprecipitate and small batch factor IX-concentrates were replaced by virus inactivated products in the last part of the 1980s. Fractionation was performed abroad by contract with Octapharma after tenders on the European market. All Norwegian blood banks (>50) participated in the Project. Total yearly production was 50-60 tons of mainly recovered plasma. From 1993 solvent detergent (SD) treated plasma has replaced other plasma for transfusion. The blood banks paid for the fractionation and/or viral inactivation process, while the plasma remained the property of the blood banks and the final products were returned to the blood banks. The Project sold surplus products to other Norwegian blood banks and the majority of the coagulation factor concentrates to The Institute of Haemophilia and Rikshospitalet University Hospital. Both plasma and blood bank quality was improved by the Project. Clinical experience with the products has been satisfactory and self-sufficiency has been achieved for all major plasma proteins and SD plasma, but a surplus exceeding 3 years consumption of albumin has accumulated due to decreasing clinical use.The Project has secured high yields of the fractionated products and the net income from the produced products is NOK 1115 (140 Euros or US dollars) per litre plasma. An increasing surplus of albumin and the possibility of significant sales abroad of currently not fractionated IVIgG, could lead to a reorganisation of the Project from that of a co-ordinator to a national plasma handling unit. This unit could buy the plasma from the blood banks and have the plasma fractionated by contract after tender, before selling the products back for cost recovery. The small blood banks could produce plasma for products for the Norwegian market, while surplus products from the larger blood banks which are

  10. Student nurse selection and predictability of academic success: The Multiple Mini Interview project.

    Gale, Julia; Ooms, Ann; Grant, Robert; Paget, Kris; Marks-Maran, Di

    2016-05-01

    With recent reports of public enquiries into failure to care, universities are under pressure to ensure that candidates selected for undergraduate nursing programmes demonstrate academic potential as well as characteristics and values such as compassion, empathy and integrity. The Multiple Mini Interview (MMI) was used in one university as a way of ensuring that candidates had the appropriate numeracy and literacy skills as well as a range of communication, empathy, decision-making and problem-solving skills as well as ethical insights and integrity, initiative and team-work. To ascertain whether there is evidence of bias in MMIs (gender, age, nationality and location of secondary education) and to determine the extent to which the MMI is predictive of academic success in nursing. A longitudinal retrospective analysis of student demographics, MMI data and the assessment marks for years 1, 2 and 3. One university in southwest London. One cohort of students who commenced their programme in September 2011, including students in all four fields of nursing (adult, child, mental health and learning disability). Inferential statistics and a Bayesian Multilevel Model. MMI in conjunction with MMI numeracy test and MMI literacy test shows little or no bias in terms of ages, gender, nationality or location of secondary school education. Although MMI in conjunction with numeracy and literacy testing is predictive of academic success, it is only weakly predictive. The MMI used in conjunction with literacy and numeracy testing appears to be a successful technique for selecting candidates for nursing. However, other selection methods such as psychological profiling or testing of emotional intelligence may add to the extent to which selection methods are predictive of academic success on nursing. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. Practicum projects of value: a successful strategic partnership between nurse executives and master's level academia.

    Hahn, Joyce A

    2010-01-01

    The opportunity exists for academia and the nursing executive community to collaboratively create cultures of excellence. One university formed relationships of collaborative synergy with nurse executives to provide practicum experiences of value for both the graduate nursing administration students and the health care facilities. The strategic preceptor partnerships offer graduate students the invaluable opportunity to experience the in-depth, real world perspective of nursing administration resulting in the enrichment of their academic scholarship. A final practicum work project is designed collaboratively with the preceptor and completed by the end of the second practicum semester. The resulting practicum project is an example of a mutually rewarding experience for the graduate nursing administration student and the preceptor. The collaborative synergistic model is a win-win situation for the university and the health care facility.

  12. Successful community relations efforts at the Weldon Spring Site Remedial Action Project

    McKee, James E. Jr.; Meyer, Linda L.

    1992-01-01

    The Weldon Spring Site Remedial Action Project (WSSRAP) Community Relations Program involves many participants from the U.S. Department of Energy (DOE) and the Prime Management Contractor (PMC) composed of M.K. Ferguson and Jacobs Engineering. The proactive community relations plan exceeds the compliance requirements of NEPA and CERCLA and is coordinated by a three-person staff of professional communicators. The program permeates many of the operating decisions and the result has been public acceptance of the Project and its actions to date, which has been to conduct remedial actions that will place the site in a radiologically and chemically safe condition, eliminating potential hazards to the public and environment. (author)

  13. Successes and challenges of north–south partnerships – key lessons from the African/Asian Regional Capacity Development projects

    Rosanna Färnman

    2016-10-01

    Full Text Available Introduction: Increasing efforts are being made globally on capacity building. North–south research partnerships have contributed significantly to enhancing the research capacity in low- and middle-income countries (LMICs over the past few decades; however, a lack of skilled researchers to inform health policy development persists, particularly in LMICs. The EU FP7 funded African/Asian Regional Capacity Development (ARCADE projects were multi-partner consortia aimed to develop a new generation of highly trained researchers from universities across the globe, focusing on global health-related subjects: health systems and services research and research on social determinants of health. This article aims to outline the successes, challenges and lessons learned from the life course of the projects, focusing on the key outputs and experiences of developing and implementing these two projects together with sub-Saharan African, Asian and European institution partners. Design: Sixteen participants from 12 partner institutions were interviewed. The data were analysed using thematic content analysis, which resulted in four themes and three sub-categories. These data were complemented by a review of project reports. Results: The results indicated that the ARCADE projects have been successful in developing and delivering courses, and have reached over 920 postgraduate students. Some partners thought the north–south and south–south partnerships that evolved during the project were the main achievement. However, others found there to be a ‘north–south divide’ in certain aspects. Challenges included technical constraints and quality assurance. Additionally, adapting new teaching and learning methods into current university systems was challenging, combined with not being able to award students with credits for their degrees. Conclusion: The ARCADE projects were introduced as an innovative and ambitious project idea, although not designed

  14. The success of the 11-Tesla project and its potential beyond particle physics

    CERN Bulletin

    2013-01-01

    On 7 March, the 1-metre-long single-aperture dipole model magnet under testing at Fermilab reached a current of 12.54 kA corresponding to a bore field of 11.5 Tesla, thus surpassing the goal set for the 11 T dipole project.   Computer generated model of the FNAL 1 metre 11 T dipole model magnet and a pair of CERN coils. Image: courtesy of Don Mitchell, FNAL. The 11-Tesla dipole project originated from a proposal made by High Luminosity LHC project coordinator, Lucio Rossi, in September 2010. To cope with the increasing amount of debris hitting the magnets when increasing the number of collisions produced by the LHC, he suggested replacing a few 8-Tesla dipole magnets in the LHC tunnel with shorter, stronger 11-Tesla magnets in order to create enough space to install additional collimators. The only way to achieve this goal is to use advanced niobium-tin technology. Rossi’s proposal aligned well with the goals of Fermilab’s High-Field Magnet R&D programme, which aims t...

  15. Waste-efficient materials procurement for construction projects: A structural equation modelling of critical success factors.

    Ajayi, Saheed O; Oyedele, Lukumon O

    2018-05-01

    Albeit the understanding that construction waste is caused by activities ranging from all stages of project delivery process, research efforts have been concentrated on design and construction stages, while the possibility of reducing waste through materials procurement process is widely neglected. This study aims at exploring and confirming strategies for achieving waste-efficient materials procurement in construction activities. The study employs sequential exploratory mixed method approach as its methodological framework, using focus group discussion, statistical analysis and structural equation modelling. The study suggests that for materials procurement to enhance waste minimisation in construction projects, the procurement process would be characterised by four features. These include suppliers' commitment to low waste measures, low waste purchase management, effective materials delivery management and waste-efficient Bill of Quantity, all of which have significant impacts on waste minimisation. This implies that commitment of materials suppliers to such measures as take back scheme and flexibility in supplying small materials quantity, among others, are expected of materials procurement. While low waste purchase management stipulates the need for such measures as reduced packaging and consideration of pre-assembled/pre-cut materials, efficient delivery management entails effective delivery and storage system as well as adequate protection of materials during the delivery process, among others. Waste-efficient specification and bill of quantity, on the other hand, requires accurate materials take-off and ordering of materials based on accurately prepared design documents and bill of quantity. Findings of this study could assist in understanding a set of measures that should be taken during materials procurement process, thereby corroborating waste management practices at other stages of project delivery process. Copyright © 2018. Published by Elsevier Ltd.

  16. Software project effort estimation foundations and best practice guidelines for success

    Trendowicz, Adam

    2014-01-01

    Software effort estimation is one of the oldest and most important problems in software project management, and thus today there are a large number of models, each with its own unique strengths and weaknesses in general, and even more importantly, in relation to the environment and context in which it is to be applied.Trendowicz and Jeffery present a comprehensive look at the principles of software effort estimation and support software practitioners in systematically selecting and applying the most suitable effort estimation approach. Their book not only presents what approach to take and how

  17. A novel method of providing a library of n-mers or biopolymers

    2012-01-01

    The present invention relates to a method of providing a library of n-mer sequences, wherein the library is composed of an n-mer sequence. Also the invention concerns a method of providing a library of biopolymer sequences having one or more n-mers in common. Further provided are specific primers...

  18. Cross host transmission in the emergence of MERS coronavirus

    C.B.E.M. Reusken (Chantal); V.S. Raj (Stalin); M.P.G. Koopmans D.V.M. (Marion); B.L. Haagmans (Bart)

    2016-01-01

    textabstractCoronaviruses (CoVs) able to infect humans emerge through cross-host transmission from animals. There is substantial evidence that the recent Middle East respiratory syndrome (MERS)-CoV outbreak is fueled by zoonotic transmission from dromedary camels. This is largely based on the fact

  19. The trans influence in mer-trichloronitridobis(triphenylarsine)ruthenium(VI)

    Magnussen, Magnus; Bendix, Jesper

    2003-01-01

    The title compound, mer-[RuCl(3)N(C(18)H(15)As)(2)], is the first structurally characterized example of a nitride complex in which ruthenium is six-coordinated to monodentate ligands only. The Ru[triple-bond]N bond length [1.6161 (15) A] is relatively long, and the trans influence of the nitride...

  20. Transmission of MERS-coronavirus in household contacts

    Drosten, Christian; Meyer, Benjamin; Müller, Marcel A; Corman, Victor M; Al-Masri, Malak; Hossain, Raheela; Madani, Hosam; Sieberg, Andrea; Bosch, Berend Jan|info:eu-repo/dai/nl/273306049; Lattwein, Erik; Alhakeem, Raafat F; Assiri, Abdullah M; Hajomar, Waleed; Albarrak, Ali M; Al-Tawfiq, Jaffar A; Zumla, Alimuddin I; Memish, Ziad A

    2014-01-01

    BACKGROUND: Strategies to contain the Middle East respiratory syndrome coronavirus (MERS-CoV) depend on knowledge of the rate of human-to-human transmission, including subclinical infections. A lack of serologic tools has hindered targeted studies of transmission. METHODS: We studied 26 index

  1. [Doctoral thesis projects for medical students? Retrospective estimation of the fraction of successfully completed medical doctoral thesis projects at Witten/Herdecke University].

    Scharfenberg, Janna; Schaper, Katharina; Krummenauer, Frank

    2014-01-01

    The German "Dr med" plays a specific role in doctoral thesis settings since students may start the underlying doctoral project during their studies at medical school. If a Medical Faculty principally encourages this approach, then it should support the students in performing the respective projects as efficiently as possible. Consequently, it must be ensured that students are able to implement and complete a doctoral project in parallel to their studies. As a characteristic efficiency feature of these "Dr med" initiatives, the proportion of doctoral projects successfully completed shortly after graduating from medical school is proposed and illustrated. The proposed characteristic can be estimated by the time period between the state examination (date of completion of the qualifying medical examination) and the doctoral examination. Completion of the doctoral project "during their medical studies" was then characterised by a doctoral examination no later than 12 months after the qualifying medical state examination. To illustrate the estimation and interpretation of this characteristic, it was retrospectively estimated on the basis of the full sample of all doctorates successfully completed between July 2009 and June 2012 at the Department of Human Medicine at the Faculty of Health of the University of Witten/Herdecke. During the period of investigation defined, a total number of 56 doctoral examinations were documented, 30 % of which were completed within 12 months after the qualifying medical state examination (95% confidence interval 19 to 44 %). The median duration between state and doctoral examination was 27 months. The proportion of doctoral projects completed parallel to the medical studies increased during the investigation period from 14 % in the first year (July 2009 till June 2010) to 40 % in the third year (July 2011 till June 2012). Only about a third of all "Dr med" projects at the Witten/Herdecke Faculty of Health were completed during or close to

  2. I and C success in Korea past and present projects and a view to the future

    Ridolfo, Charles F.

    2009-01-01

    Westinghouse Electric Company, LLC (WEC) has been providing advanced Instrumentation and Control (I and C) technology for the C E System 80, Korean Standard Nuclear Power Plant (KSNP), since the early 1990's. I and C equipment and technical support has been provided for a progression of these plants including Yonggwang Units 3,4,5,6, Ulchin Units 3,4,5,6, Shin Kori Units 1 and 2, Shin Wolsong Units 1 and 2, and most recently for Shin Kori Units 3 and 4. These I and C programs have been highly successful and have helped to contribute to the outstanding plant availability for the commissioned units at Yonggwang 3,4,5, and 6 and Ulchin 3,4,5, and 6; which are currently providing power on the grid. WEC has also recently delivered I and C equipment for Shin Kori Units 1 and 2 and Shin Wolsong Units 1 and 2 and is supporting the installation and startup of the equipment. In addition, WEC is in the initial design stages for providing an integrated protection system that will be deployed at Shin Kori Units 3 and 4 which are the first units to implement the APR1400; an advanced reactor of indigenous Korean design, which is based on the previous generation Optimized Power Reactor OPR1000. The success of the I and C programs has been the result of careful consideration of the appropriate technology to employ, applying comprehensive quality assurance measures, providing appropriate technical support and consultation services, implementation of a program of continued I and C logistic support, maintaining a professional and experienced I and C work force, and maintaining a strong and mutually supportive partnership with the Korea Power Engineering Company (KOPEC) and with Korea Hydro and Nuclear Power (KHNP). WEC takes great pride in its on going I and C partnership with Korea, which has included not only providing equipment and technical support services, but also completion of a comprehensive Technology Transfer program. This program was implemented to promote local 'elf

  3. An extensible and successful method of identifying collaborators for National Library of Medicine informationist projects.

    Williams, Jeff D; Rambo, Neil H

    2015-07-01

    The New York University (NYU) Health Sciences Library used a new method to arrange in-depth discussions with basic science researchers. The objective was to identify collaborators for a new National Library of Medicine administrative supplement. The research took place at the NYU Health Sciences Library. Using the National Institutes of Health (NIH) RePORTER, forty-four researchers were identified and later contacted through individualized emails. Nine researchers responded to the email followed by six in-person or phone discussions. At the conclusion of this process, two researchers submitted applications for supplemental funding, and both of these applications were successful. This method confirmed these users could benefit from the skills and knowledge of health sciences librarians, but they are largely unaware of this.

  4. MERS-CoV infection: Mind the public knowledge gap.

    Bawazir, Amen; Al-Mazroo, Eman; Jradi, Hoda; Ahmed, Anwar; Badri, Motasim

    In August 2015, the Corona outbreak caused by Middle East respiratory syndrome coronavirus (MERS-CoV) was the 9th episode since June 2012 in Saudi Arabia. Little is known about the public awareness toward the nature or prevention of the disease. The aim of this work was to assess the knowledge of the adult population in Riyadh toward the MERS-CoV. In this cross-sectional survey, a self-administrated questionnaire was distributed to randomly selected participants visiting malls in Riyadh. The questionnaire contained measurable epidemiological and clinical MERS-CoV knowledge level variables and relevant source of information. The study included 676 participants. Mean age was 32.5 (±SD 8.6) years and 353 (47.8%) were males. Almost all participants heard about the corona disease and causative agent. The study showed a fair overall knowledge (66.0%), less knowledge on epidemiological features of the disease (58.3%), and good knowledge (90.7%) on the clinical manifestation of the MERS-CoV. Internet was the major (89.0%) source of disease information, and other sources including health care providers, SMS, television, magazines and books were low rated (all knowledge. This study concludes that there was inadequate epidemiological knowledge received by the public and the reliance mostly on the clinical manifestations to recognizing the MERS-CoV disease. Comprehensive public health education programs is important to increase awareness of simple epidemiological determinants of the disease is warranted. Copyright © 2017. Published by Elsevier Ltd.

  5. Molecular interaction study of commercial cyclic peptides and MERS-COV papain-like protease as novel drug candidate for MERS-COV

    Nasution, M. A. F.; Azzuhdi, M. G.; Tambunan, U. S. F.

    2017-07-01

    Middle-east respiratory syndrome coronavirus (MERS-CoV) has become the current outbreak, MERS-CoV infection results in illness at the respiratory system, digestive, and even lead to death with an average mortality caused by MERS-CoV infection reaches 50 %. Until now, there is not any effective vaccine or drug to ward off MERS-CoV infection. Papain-like protease (PLpro) is responsible for cleavage of a nonstructural protein that is essential for viral maturation. Inhibition of PLpro with a ligand will block the cleavage process of nonstructural protein, thus reduce the infection of MERS-CoV. Through of bioinformatics study with molecular docking and binding interaction analysis of commercial cyclic peptides, aldosterone secretion inhibiting factor (1-35) (bovine) was obtained as an inhibitor for PLpro. Thus, aldosterone secretion inhibiting factor (1-35) (bovine) has a potential as a novel candidate drug for treating MERS-CoV.

  6. Worksheet of Exogenous Variables that Impact the Success of Validation Stage of Product Delivery of a Project

    Altino José Mentzingen de Moraes

    2015-02-01

    building a solution that complies with the expectations presented by Stakeholders in the Project Result (which, as already said, are recorded in the Discipline of Scope in accordance with the Planning Stage and should meet the intended requirements of compliance in Product Delivery (which, as already said, are recorded in the Discipline of Quality in accordance with Validation Stage. In the execution of Validation Stage of Product Delivery structured in the Discipline of Quality, which occurs immediately as predecessor of the placement of the solution built in Operational Phase Production is used, as reference to parameterize the expected quality, the degree of compliance with the requirements (Essential and/or Desirable specified in the Planning Stage of Project Result structured in the Discipline of Scope. Independently of the nature of the Project (if this is to execute a solution for the Civil Construction, Software Development, Product Implementation or others Areas, may be perceived some Exogenous Variables that interfere with the achievement with success of Validation Stage of Product Delivery structured in the Discipline of Quality. The perception of these Exogenous Variables, which can interfere with Deadlines and Costs initially planned for the implementation of Validation Stage of Product Delivery, is the result of the accumulation of experiences throughout the professional career of more than 40 (forty years of author this work in projects of various types, besides their additional Technical Certifications in the field of Project Management (PMP© - Project Management Professional/PMI© - Project Management Institute and System Testing (CTFL© - Certified Tester Foundation Level/ISTQB© - International Software Testing Qualifications Board. As result of their assessments and surveys in this theme, the author identified and classified the Exogenous Variables perceived between 2 (two Aspects, which are, the Circumstantial Aspects of the Project and the Specific

  7. Complete Genome Sequence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) from the First Imported MERS-CoV Case in China.

    Lu, Roujian; Wang, Yanqun; Wang, Wenling; Nie, Kai; Zhao, Yanjie; Su, Juan; Deng, Yao; Zhou, Weimin; Li, Yang; Wang, Huijuan; Wang, Wen; Ke, Changwen; Ma, Xuejun; Wu, Guizhen; Tan, Wenjie

    2015-08-13

    On 26 May 2015, an imported Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in Guangdong Province, China, and found to be closely related to the MERS-CoV strain prevalent in South Korea. The full genome of the ChinaGD01 strain was sequenced and analyzed to investigate the epidemiology and evolution of MERS-CoV circulating in South Korea and China. Copyright © 2015 Lu et al.

  8. Hanford's 100-HX Pump and Treat Project - a Successful Blend of Science, Technology, Construction, and Project Management - 12412

    Albin, Kenneth A.; Bachand, Marie T.; Biebesheimer, Fred H.; Neshem, Dean O.; Smoot, John L. [CH2M HILL Plateau Remediation Company, Richland, Washington 99352 (United States)

    2012-07-01

    CH2M Hill Plateau Remediation Company (CHPRC) recently completed construction and start-up of the $25 million 100-HX Groundwater Pump and Treat Project for the Department of Energy (DOE) at its Hanford Reservation site in Washington State. From the onset, the 100-HX Project Leadership Team was able to successfully blend the science and technology of a state-of-the-art groundwater pump and treat system with the principles, tools, and techniques of traditional industrial-type construction and project management. From the 1940's through most of the 1980's, the United States used the Hanford Site to produce nuclear material for national defense at reactor sites located along the Columbia River. While the reactors were operational, large volumes of river water were treated with sodium dichromate (to inhibit corrosion of the reactor piping) and used as a coolant for the reactors. After a single pass through the reactor and before being discharged back to the river, the coolant water was sent to unlined retention basins to cool and to allow the short-lived radioactive contaminants to decay. As a result of these operations, hexavalent chromium was introduced to the vadose zone, and ultimately into the groundwater aquifer and the adjacent Columbia River. In addition, numerous leaks and spills of concentrated sodium dichromate stock solution over the lifetime of reactor operations led to higher concentrations of chromate in the vadose zone and groundwater in localized areas. As a result, the 100 Area was included in the National Priorities List sites under the Comprehensive Environmental Response Compensation and Liability Act of 1980 (CERCLA). The mission of the 100-HX Project is to significantly reduce the concentration of hexavalent chromium in the groundwater by treating up to 3.8 billion gallons (14,300 mega-liters) of contaminated water over its first nine years of operations. In order to accomplish this mission, groundwater scientists and geologists using

  9. [Fighting cholera in shanty-town. Successful experience of a Quebec project adapted to Peru].

    Fréchette, L; Peralta, M

    1994-12-01

    Originally designed in Quebec, the MOI project was a collaboration between two professors of social work from Quebec and two members of the Peruvian NGO called SUR in Villa de Salvador, one of poorest slum areas on the outskirts of Lima. The approach is founded on the notion that the body is the primary instrument through which a person can interact with the world around him or her, and that the physical and mental health of an individual exists within the context of healthy conditions of life that must include at least a basic social and health infrastructure as well as healthy hygiene practices on the part of individuals, families and the local community. Preschool children (ages 4-6), study a different part of the body and its proper care each week through classroom observation games. Parents' help is requested to modify unhealthy conditions, at the same time to enrich the children's experience and to mobilize the community to improve health conditions. During the 1991 cholera epidemic, not a single case was counted in the experimental district, despite its clearly socio-economically impoverished status, and despite the fact that the Ministry of Health recorded 86,650 cases in the Lima-Callao district, accounting for about 40% of the total number of cases in the Peru. The prior work made it easier to explain how cholera is spread and what special new measures needed to be taken in addition to the hygiene habits already taught.(ABSTRACT TRUNCATED AT 250 WORDS)

  10. Project WANT - Women's Access to Nuclear Technology, a successful industry/education partnership

    Widen, W.C.; Roth, G.L.; NIU)

    1987-01-01

    In 1984, the U.S. Congress issued the Carl D. Perkins Act, which charges vocational educators to increase their focus on two broad themes: (a) the elimination of sexual bias and sexual stereotyping in vocational education and (b) the provision of marketable skills to the economically deprived of the nation's work force. In response to this charter, an industry/education partnership was established among the Illinois State Board of Education, Norther Illinois University, and the Westinbghouse Nuclear Training Center. In essence, these partners established Project WANT - Women's Access to Nuclear Technology - with two premier goals: (a) to increase women's awareness regarding nuclear career opportunities and (b) to train and place women in technical professions within the nuclear industry. Feedback from the U.S. Department of Energy (DOE), the Atomic Industrial Forum, and the Bureau of Labor Statistics identifies that <2% of all technical positions within the nuclear power industry are held by women. Hence, one may conclude that there is a definite need to promote sexual equity in the nuclear industry and that Illinois represents a unique environment of opportunity to accomplish this

  11. Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia, 2010 to 2013.

    Hemida, M G; Perera, R A; Wang, P; Alhammadi, M A; Siu, L Y; Li, M; Poon, L L; Saif, L; Alnaeem, A; Peiris, M

    2013-12-12

    In Saudi Arabia, including regions of Riyadh and Al Ahsa, pseudoparticle neutralisation (ppNT) and microneutralisation (MNT) tests detected no antibodies to Middle East Respiratory Syndrome coronavirus (MERS-CoV) in sheep (n= 100), goats (n= 45), cattle (n= 50) and chickens (n= 240). Dromedary camels however, had a high prevalence of MERS-CoV antibodies. Bovine coronavirus (BCoV) infected sera from cattle had no cross-reactivity in MERS-CoV ppNT or MNT, while many dromedary camels’ sera reacted to both BCoV and MERS-CoV. Some nevertheless displayed specific serologic reaction profiles to MERS-CoV.

  12. Project success: A methodological and evaluative case study of the early alert program interventions

    Larkins, Randy James

    environment possible in whatever form the focus group takes place. Suggestions for future research include recruiting participants from online classes and attempting to engage more disenfranchised students in other studies. Similar to new types of focus group methods due to technological advances, academic interventions for students facing failing grades are also increasing due to the internet and new methods of service delivery. The contextual aspect of this research involved asking students to participate in an initial focus group session, four weeks of email updates, and a final focus group session in which students participated in the same group as the initial session. The purpose of the focus groups was to evaluate whether or not the universities' attempts to help students succeed in a course known in the past for high failure rates through a program known as the Early Alert Project was succeeding. Interview data were analyzed using thematic coding to evaluate available support services using a comprehensive implementation evaluation model which included effort, monitoring, process, components; and treatment specification. The primary findings were although students believed the university was trying to help them succeed, Early Alert Project efforts were adversely received. In addition, participants felt that although there were enough support services to help them succeed in the course, the components of the support system were confusing and not organized in any systematic manner. Suggestions for further research included researching delivery of this type of communication that might be more amenable to the students who received it and applying this research to other courses to examine whether the same results occur. Finally, implications of the use of traditional methods and academic support services are discussed in addition to the effect of the research itself upon its participants.

  13. Looking back on a successful project. The Restoration of the Royal Palace in Amsterdam

    Bert van Bommel

    2013-06-01

    Full Text Available After 1968, few changes were made to the Royal Palace in Amsterdam and eventually the palace was no longer functionally and technically up-to-date. Initially, the most recent restoration was only aimed at remedying that situation. Also, the project was split up and priority was given to fixing up the interior. Gradually, the actual restoration gained prominence. In 2007 it was decided to also restore the 1808 furniture. Until 2006, the government architect had hardly been involved in the restoration of the interior. This architect, Krijn van den Ende, was advised by various committees. Prior restorations (1929-1939 and 1960-1968 had restored the palace to its 17th-century state as best as possible. The most recent restoration respected this, while at the same time it aimed at connecting the 17th century character of the building to the unique collection of Empire furniture. This furniture was restored, as were the chandeliers and candelabras. All the ceilings on the first floor were studied and treated and the paintings between the beams were meticulously restored. A very important aspect was the restoration of the so-called ‘Bataven’ series in the galleries. Much of the work concerned making the building conform to contemporary standards. Once again the palace is now a suitable venue for official occasions. The inevitable addition of a lift did however cause quite a stir. Accessibility was improved and more representative rooms are now open to the public than before. The government architect was involved already in the preparatory stages of the second part of the restoration, which concerned the façades and the roofs. In executing the actual work a support committee provided advice and direction on his behalf. Although the sandstone is generally of a high quality, before 1968 a limited number of deteriorating blocks had been replaced. This time too, a number of blocks needed attention. The heavy scaffolding that needed to be installed for

  14. Success Stories in Radiotherapy Development Projects: Radiotherapy Service in Mauritania. Chapter 28.5

    Rosenblatt, E.; Zubizarreta, E.; Djeutie, A.; Meghzifene, A.; Mohamedou, M.M.

    2017-01-01

    Mauritania, a country of 3.4 million people, did not have any radiotherapy facility until 2009. As is usually the case in countries without radiotherapy services, cancer patients with a need for this treatment travelled to neighbouring countries (Morocco or Tunisia) or to Europe to receive it, or switched to alternative forms of care. Cancer is a rising cause of death in Mauritania. According to WHO estimates, about 2200 people died of cancer in 2011, of whom 1400 were aged below 70 years of age. The number of patients sent abroad for treatment by the National Health Insurance Fund rose to 500 patients in 2007, causing a significant drain on the State budget. Cancer was the main cause of health related travel abroad. The average cost of such travel was two million ouguiya per patient (US $8000). Through a technical cooperation project initiated in 2009 between the Mauritanian Government and the IAEA, the latter assisted the country with the establishment and operation of its first radiotherapy facility. The National Oncology Centre, including a radiotherapy department, was built in Nouakchott in 2010 and began operation in early 2011 with a limited staff, all hired from abroad. Its equipment includes a modern medical linac with a multileaf collimator and portal imaging, a CT simulator, a 3-D CRT TPS and a remote afterloading HDR brachytherapy system. The centre was planned with an additional bunker, where a second accelerator can be installed in the future. Except for the training of the Department Head, the entire professional team has been trained through the IAEA’s technical cooperation fellowship programme. The centre treated a total of 250 patients in 2012 and treated 176 in the first half of 2013. Most patients undergo simulation and computerized radiotherapy treatment planning. The centre ensures the sustainability of the equipment through full maintenance contracts for the major radiation equipment and source replacements for the HDR brachytherapy unit.

  15. Preventing cleavage of Mer promotes efferocytosis and suppresses acute lung injury in bleomycin treated mice

    Lee, Ye-Ji; Lee, Seung-Hae; Youn, Young-So; Choi, Ji-Yeon; Song, Keung-Sub; Cho, Min-Sun; Kang, Jihee Lee

    2012-01-01

    Mer receptor tyrosine kinase (Mer) regulates macrophage activation and promotes apoptotic cell clearance. Mer activation is regulated through proteolytic cleavage of the extracellular domain. To determine if membrane-bound Mer is cleaved during bleomycin-induced lung injury, and, if so, how preventing the cleavage of Mer enhances apoptotic cell uptake and down-regulates pulmonary immune responses. During bleomycin-induced acute lung injury in mice, membrane-bound Mer expression decreased, but production of soluble Mer and activity as well as expression of disintegrin and metalloproteinase 17 (ADAM17) were enhanced . Treatment with the ADAM inhibitor TAPI-0 restored Mer expression and diminished soluble Mer production. Furthermore, TAPI-0 increased Mer activation in alveolar macrophages and lung tissue resulting in enhanced apoptotic cell clearance in vivo and ex vivo by alveolar macrophages. Suppression of bleomycin-induced pro-inflammatory mediators, but enhancement of hepatocyte growth factor induction were seen after TAPI-0 treatment. Additional bleomycin-induced inflammatory responses reduced by TAPI-0 treatment included inflammatory cell recruitment into the lungs, levels of total protein and lactate dehydrogenase activity in bronchoalveolar lavage fluid, as well as caspase-3 and caspase-9 activity and alveolar epithelial cell apoptosis in lung tissue. Importantly, the effects of TAPI-0 on bleomycin-induced inflammation and apoptosis were reversed by coadministration of specific Mer-neutralizing antibodies. These findings suggest that restored membrane-bound Mer expression by TAPI-0 treatment may help resolve lung inflammation and apoptosis after bleomycin treatment. -- Highlights: ►Mer expression is restored by TAPI-0 treatment in bleomycin-stimulated lung. ►Mer signaling is enhanced by TAPI-0 treatment in bleomycin-stimulated lung. ►TAPI-0 enhances efferocytosis and promotes resolution of lung injury.

  16. Constitutive synthesis of a transport function encoded by the Thiobacillus ferrooxidans merC gene cloned in Escherichia coli

    Kusano, Tomonobu; Ji, Guangyong; Silver, S.; Inoue, Chihiro

    1990-01-01

    Mercuric reductase activity determined by the Thiobacillus ferrooxidans merA gene (cloned and expressed constitutively in Escherichia coli) was measured by volatilization of 203 Hg 2+ . (The absence of a merR regulatory gene in the cloned Thiobacillus mer determinant provides a basis for the constitutive synthesis of this system.) In the absence of the Thiobacillus merC transport gene, the mercury volatilization activity was cryptic and was not seen with whole cells but only with sonication-disrupted cells. The Thiobacillus merC transport function was compared with transport via the merT-merP system of plasmid pDU1358. Both systems, cloned and expressed in E. coli, governed enhanced uptake of 203 Hg 2+ in a temperature- and concentration-dependent fashion. Uptake via MerT-MerP was greater and conferred greater hypersensitivity to Hg 2+ than did uptake with MerC. Mercury uptake was inhibited by N-ethylmaleimide but not by EDTA. Ag + salts inhibited mercury uptake by the MerT-MerP system but did not inhibit uptake via MerC. Radioactive mercury accumulated by the MerT-MerP and by the MerC systems was exchangeable with nonradioactive Hg 2+

  17. Nucleation and Growth Kinetics from LaMer Burst Data.

    Chu, Daniel B K; Owen, Jonathan S; Peters, Baron

    2017-10-12

    In LaMer burst nucleation, the individual nucleation events happen en masse, quasi-simultaneously, and at nearly identical homogeneous conditions. These properties make LaMer burst nucleation important for applications that require monodispersed particles and also for theoretical analyses. Sugimoto and co-workers predicted that the number of nuclei generated during a LaMer burst depends only on the solute supply rate and the growth rate, independent of the nucleation kinetics. Some experiments confirm that solute supply kinetics control the number of nuclei, but flaws in the original theoretical analysis raise questions about the predicted roles of growth and nucleation kinetics. We provide a rigorous analysis of the coupled equations that govern concentrations of nuclei and solutes. Our analysis confirms that the number of nuclei is largely determined by the solute supply and growth rates, but our predicted relationship differs from that of Sugimoto et al. Moreover, we find that additional nucleus size dependent corrections should emerge in systems with slow growth kinetics. Finally, we show how the nucleation kinetics determine the particle size distribution. We suggest that measured particle size distributions might therefore provide ways to test theoretical models of homogeneous nucleation kinetics.

  18. Enzymatic Mercury Detoxification: The Regulatory Protein MerR

    Ctortecka, B; Walsh, C T; Comess, K M

    2002-01-01

    Mercury ions and organomercurial reagents are extremely toxic due to their affinity for thiol groups. Many bacteria contain an elaborate detoxification system for a metabolic conversion of toxic Hg$^{2+}$ or organomercurials to less toxic elemental Hg$^0$. The main components of the enzymatic mercury detoxification (see Fig. 1) are the regulatory protein MerR (mercury responsive genetic switch), the organomercurial lyase MerB (cleavage of carbon mercury bonds), and the mercuric ion reductase MerA (reduction of mercuric ions). In these proteins Hg$^{2+}$ is usually coordinated by the thiol groups of cysteines. We utilize the nuclear quadrupole interaction (NQI) of ${\\rm^{199m}}$Hg detected by time differential perturbed angular correlation (TDPAC) to identify the Hg metal site geometries in these proteins in order to elucidate the molecular origin of the ultrasensitivity, selectivity and reaction mechanism of this detoxification system. The short lived TDPAC probe ${\\rm^{199m}}$Hg ($\\tau_{1/2} =$ 43 min) is su...

  19. Uninformative variable elimination assisted by Gram-Schmidt Orthogonalization/successive projection algorithm for descriptor selection in QSAR

    Omidikia, Nematollah; Kompany-Zareh, Mohsen

    2013-01-01

    Employment of Uninformative Variable Elimination (UVE) as a robust variable selection method is reported in this study. Each regression coefficient represents the contribution of the corresponding variable in the established model, but in the presence of uninformative variables as well as colline......Employment of Uninformative Variable Elimination (UVE) as a robust variable selection method is reported in this study. Each regression coefficient represents the contribution of the corresponding variable in the established model, but in the presence of uninformative variables as well...... as collinearity reliability of the regression coefficient's magnitude is suspicious. Successive Projection Algorithm (SPA) and Gram-Schmidt Orthogonalization (GSO) were implemented as pre-selection technique for removing collinearity and redundancy among variables in the model. Uninformative variable elimination...

  20. Andragogical Modeling and the Success of the "EMPACTS" project-based learning model in the STEM disciplines: A decade of growth and learner success in the 2Y College Learning Environment.

    Phillips, C. D.; Thomason, R.; Galloway, M.; Sorey, N.; Stidham, L.; Torgerson, M.

    2014-12-01

    EMPACTS (Educationally Managed Projects Advancing Curriculum, Technology/Teamwork and Service) is a project-based, adult learning modelthat is designed to enhance learning of course content through real-world application and problem solving self directed and collaborative learning use of technology service to the community EMPACTS students are self-directed in their learning, often working in teams to develop, implement, report and present final project results. EMPACTS faculty use community based projects to increase deeper learning of course content through "real-world" service experiences. Learners develop personal and interpersonal work and communication skills as they plan, execute and complete project goals together. Technology is used as a tool to solve problems and to publish the products of their learning experiences. Courses across a broad STEM curriculum integrate the EMPACTS project experience into the overall learning outcomes as part of the learning college mission of preparing 2Y graduates for future academic and/or workforce success. Since the program began in 2005, there have been over 200 completed projects/year. Student driven successes have led to the establishment of an EMPACTS Technology Corp, which is funded through scholarship and allows EMPACTS learners the opportunity to serve and learn from one another as "peer instructors." Engineering and 3D graphic design teams have written technology proposals and received funding for 3D printing replication projects, which have benefited the college as a whole through grant opportunities tied to these small scale successes. EMPACTS students engage in a variety of outreachprojects with area schools as they share the successes and joys of self directed, inquiry, project based learning. The EMPACTS Program has successfully trained faculty and students in the implementation of the model and conduct semester to semester and once a year workshops for college and K-12 faculty, who are interested in

  1. A Novel Role of MerC in Methylmercury Transport and Phytoremediation of Methylmercury Contamination.

    Sone, Yuka; Uraguchi, Shimpei; Takanezawa, Yasukazu; Nakamura, Ryosuke; Pan-Hou, Hidemitsu; Kiyono, Masako

    2017-01-01

    MerC, encoded by merC in the transposon Tn21 mer operon, is a heavy metal transporter with potential applications for phytoremediation of heavy metals such as mercuric ion and cadmium. In this study, we demonstrate that MerC also acts as a transporter for methylmercury. When MerC was expressed in Escherichia coli XL1-Blue, cells became hypersensitive to CH 3 Hg(I) and the uptake of CH 3 Hg(I) by these cells was higher than that by cells of the isogenic strain. Moreover, transgenic Arabidopsis plants expressing bacterial MerC or MerC fused to plant soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) accumulated CH 3 Hg(I) effectively and their growth was comparable to the wild-type plants. These results demonstrate that when the bacterium-derived merC gene is ectopically introduced in genetically modified plants, MerC expression in the transgenic plants promotes the transport and sequestration of methylmercury. Thus, our results show that the expression of merC in Arabidopsis results in transgenic plants that could be used for the phytoremediation and elimination of toxic methylmercury from the environment.

  2. University of Colorado CubeSat Student Projects as Successful Model for Teaching Students about Engineering Practices

    Palo, S. E.; Li, X.; Woods, T. N.; Kohnert, R.

    2014-12-01

    There is a long history of cooperation between students at the University of Colorado, Boulder and professional engineers and scientists at LASP, which has led to many successful space missions with direct student involvement. The recent student-led missions include the Student Nitric Oxide Explorer (SNOE, 1998 - 2002), the Student Dust Counter (SDC) on New Horizons (2006 - present), the Colorado Student Space Weather Experiment (CSSWE), being a very successful NSF CubeSat that launched in September 2012, and the NASA Miniature X-ray Solar Spectrometer (MinXSS) CubeSat (launch will be in early 2015). Students are involved in all aspects of the design, and they experience the full scope of the mission process from concept, to fabrication and test, and mission operations. A significant part of the student involvement in the CubeSat projects is gained by using the CubeSat development as a focal point for an existing two-semester course sequence in CU's Aerospace Engineering Sciences (AES) Department: the Space Hardware Design section of Graduate Projects I & II (ASEN 5018 & ASEN 6028). The goal of these courses is to teach graduate students how to design and build systems using a requirement-based approach and fundamental systems engineering practices. The two-semester sequence takes teams of about 15 students from requirements definition and preliminary design through manufacturing, integration, and testing. In addition to the design process, students learn key professional skills such as working effectively in groups, finding solutions to open-ended problems, and actually building a system to their own set of specifications. The partnership between AES and LASP allows us to include engineering professionals in the mix, thus more effectively training science and engineering students for future roles in the civilian or commercial space industry. The mentoring process with LASP engineers helps to mitigate risk of the inexperience of the students and ensures consistent

  3. A modification of the successive projections algorithm for spectral variable selection in the presence of unknown interferents.

    Soares, Sófacles Figueredo Carreiro; Galvão, Roberto Kawakami Harrop; Araújo, Mário César Ugulino; da Silva, Edvan Cirino; Pereira, Claudete Fernandes; de Andrade, Stéfani Iury Evangelista; Leite, Flaviano Carvalho

    2011-03-09

    This work proposes a modification to the successive projections algorithm (SPA) aimed at selecting spectral variables for multiple linear regression (MLR) in the presence of unknown interferents not included in the calibration data set. The modified algorithm favours the selection of variables in which the effect of the interferent is less pronounced. The proposed procedure can be regarded as an adaptive modelling technique, because the spectral features of the samples to be analyzed are considered in the variable selection process. The advantages of this new approach are demonstrated in two analytical problems, namely (1) ultraviolet-visible spectrometric determination of tartrazine, allure red and sunset yellow in aqueous solutions under the interference of erythrosine, and (2) near-infrared spectrometric determination of ethanol in gasoline under the interference of toluene. In these case studies, the performance of conventional MLR-SPA models is substantially degraded by the presence of the interferent. This problem is circumvented by applying the proposed Adaptive MLR-SPA approach, which results in prediction errors smaller than those obtained by three other multivariate calibration techniques, namely stepwise regression, full-spectrum partial-least-squares (PLS) and PLS with variables selected by a genetic algorithm. An inspection of the variable selection results reveals that the Adaptive approach successfully avoids spectral regions in which the interference is more intense. Copyright © 2011 Elsevier B.V. All rights reserved.

  4. Associate Degree Nursing: Model Prerequisites Validation Study. California Community College Associate Degree Programs by The Center for Student Success, A Health Care Initiative Sponsored Project.

    Phillips, Brad C.; Spurling, Steven; Armstrong, William A.

    California faces a severe nursing shortage, with the number of registered nurses far below what is required to avert a potential state health care crisis. The Associate Degree Nursing (ADN) Project is a joint project involving scholars, educational researchers, and analysts from the Center for Student Success (CSS) housed at City College of San…

  5. Discovery of novel bat coronaviruses in south China that use the same receptor as MERS coronavirus.

    Luo, Chu-Ming; Wang, Ning; Yang, Xing-Lou; Liu, Hai-Zhou; Zhang, Wei; Li, Bei; Hu, Ben; Peng, Cheng; Geng, Qi-Bin; Zhu, Guang-Jian; Li, Fang; Shi, Zheng-Li

    2018-04-18

    Middle East respiratory syndrome coronavirus (MERS-CoV) has represented a human health threat since 2012. Although several MERS-related CoVs, which belong to the same species as MERS-CoV, have been identified from bats, they do not use the MERS-CoV receptor, dipeptidyl peptidase 4 (DPP4). Here, we screened 1059 bat samples from at least 30 bat species collected in different regions in south China and identified 89 strains of lineage C betacoronaviruses, including Tylonycteris pachypus HKU4 , Pipistrellus pipistrellus HKU5, and MERS-related CoVs. We sequenced the full-length genomes of two positive samples collected from the great evening bat, Ia io , from Guangdong Province. The two genomes were highly similar and exhibited genomic structures identical to those of other lineage C betacoronaviruses. While they exhibited genome-wide nucleotide identities of only 75.3 to 81.2% with other MERS-related CoVs, their gene-coding regions were highly similar to their counterparts, except in the case of the spike proteins. Further protein--protein interaction assays demonstrated that the spike proteins of these MERS-related CoVs bind to the receptor DPP4. Recombination analysis suggested that the newly discovered MERS-related CoVs might have acquired their spike genes from a DPP4-recognizing bat HKU4. Our study provides further evidence that bats represent the evolutionary origins of MERS-CoV. IMPORTANCE Previous studies suggested that the Middle East respiratory syndrome coronavirus (MERS-CoV) may have originated in bats. However, its evolutionary path from bats to humans remains unclear. In this study, we discovered 89 novel lineage C betacoronaviruses (BetaCoVs) in eight bat species. We provide the evidence of a MERS-related CoV derived from the great evening bat that uses the same host receptor as human MERS-CoV. This virus also provides evidence for a natural recombination event between the bat MERS-related CoV and another bat coronavirus HKU4. Our study expands the host

  6. Impact of Role Clarity and Strategic Fit on Average Project Success: Moderating Role of Market Turbulence on Telecom Companies of Pakistan

    Najam UL MABOOD

    2017-06-01

    Full Text Available Advancement in technology has reshaped the businesses across the globe forcing companies to perform tasks and activities in the form of projects. Stakeholder behavior, stakeholder management, strategic fit, role and task clarity are some of the factors that redesign the project success. The current study examine the impact of strategic fit and role clarity on the Average project success and further it enlightens the moderating role of Market turbulence on the relationship between the aforementioned independent and dependent variables. The population of the study comprises of telecom sector of Pakistan. The Data was collected from 201 project team members working on diverse project in Telecom companies of Rawalpindi and Islamabad. The Data was gathered through a questionnaires measured on Likert scale adopted from the study of Beringer, Jonas & Kock (2013. Each Questionnaire comprises of 3 items to measure each variable. SPSS 20.0 Version was used to analyze the data by applying Pearson correlation and multiple regression analysis technique. Findings depicted that role clarity and strategic fit contributed significantly in enhancing success of a project. Results further evidenced that market turbulence negatively moderated the relationship of independent variables on Average project success. The study at the end highlights recommendations for the future researchers.

  7. Novel Tc-99m labeled ELR-containing 6-mer peptides for tumor imaging in epidermoid carcinoma xenografts model. A pilot study

    Kim, Dae-Weung; Kim, Woo-Hyoung; Kim, Myoung-Hyoun; Kim, Chang-Guhn

    2013-01-01

    ELR-containing peptides targeting CXCR2 could be the excellent candidate for targeting ligand of molecular tumor imaging. In this study, we had developed two ELR-containing 6-mer peptides and evaluated the diagnostic performance of Tc-99m labeled 6-mer peptides as a molecular imaging agent in murine models bearing KB epidermoid carcinoma. Peptides were synthesized using Fmoc solid phase peptide synthesis. Radiolabeling efficiency with Tc-99m was evaluated using instant thin-layer chromatography. In KB epidermoid cancer-bearing mice, gamma images had acquired and tumor-to-muscle uptake ratio was calculated. Competition and biodistribution studies had performed. Two 6-mer peptides, ELR-ECG and ECG-ELR were successfully synthesized. After radiolabeling procedures with Tc-99m, the complex Tc-99m ELR-ECG and Tc-99m ECG-ELR were prepared in high yield. In the gamma camera imaging of murine model, Tc-99m ELR-ECG was substantially accumulated in the subcutaneously engrafted tumor and tumor uptake had been suppressed by the free ELR co-injection. However, Tc-99m ECG-ELR was minimally accumulated in the tumor. Two ELR-containing 6-mer peptides, ELR-ECG and ECG-ELR, were developed as a molecular imaging agent to target CXCR2 of epidermoid carcinoma. Tc-99m ELR-ECG had showed significant uptake in tumor and it was good candidate for a tumor imaging. (author)

  8. A mouse model for MERS coronavirus-induced acute respiratory distress syndrome.

    Cockrell, Adam S; Yount, Boyd L; Scobey, Trevor; Jensen, Kara; Douglas, Madeline; Beall, Anne; Tang, Xian-Chun; Marasco, Wayne A; Heise, Mark T; Baric, Ralph S

    2016-11-28

    Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel virus that emerged in 2012, causing acute respiratory distress syndrome (ARDS), severe pneumonia-like symptoms and multi-organ failure, with a case fatality rate of ∼36%. Limited clinical studies indicate that humans infected with MERS-CoV exhibit pathology consistent with the late stages of ARDS, which is reminiscent of the disease observed in patients infected with severe acute respiratory syndrome coronavirus. Models of MERS-CoV-induced severe respiratory disease have been difficult to achieve, and small-animal models traditionally used to investigate viral pathogenesis (mouse, hamster, guinea-pig and ferret) are naturally resistant to MERS-CoV. Therefore, we used CRISPR-Cas9 gene editing to modify the mouse genome to encode two amino acids (positions 288 and 330) that match the human sequence in the dipeptidyl peptidase 4 receptor, making mice susceptible to MERS-CoV infection and replication. Serial MERS-CoV passage in these engineered mice was then used to generate a mouse-adapted virus that replicated efficiently within the lungs and evoked symptoms indicative of severe ARDS, including decreased survival, extreme weight loss, decreased pulmonary function, pulmonary haemorrhage and pathological signs indicative of end-stage lung disease. Importantly, therapeutic countermeasures comprising MERS-CoV neutralizing antibody treatment or a MERS-CoV spike protein vaccine protected the engineered mice against MERS-CoV-induced ARDS.

  9. MerCat: a versatile k-mer counter and diversity estimator for database-independent property analysis obtained from metagenomic and/or metatranscriptomic sequencing data

    White, Richard A.; Panyala, Ajay R.; Glass, Kevin A.; Colby, Sean M.; Glaesemann, Kurt R.; Jansson, Georg C.; Jansson, Janet K.

    2017-02-21

    MerCat is a parallel, highly scalable and modular property software package for robust analysis of features in next-generation sequencing data. MerCat inputs include assembled contigs and raw sequence reads from any platform resulting in feature abundance counts tables. MerCat allows for direct analysis of data properties without reference sequence database dependency commonly used by search tools such as BLAST and/or DIAMOND for compositional analysis of whole community shotgun sequencing (e.g. metagenomes and metatranscriptomes).

  10. YALIN ALTI SİGMA PROJELERİ İÇİN KRİTİK BAŞARI FAKTÖRLERİ (SUCCESS FACTORS FOR LEAN SIX SIGMA PROJECTS

    Ali Rıza FİRUZAN

    2012-10-01

    Full Text Available Nowadays many companies focus on various kinds of quality improvement techniques to carry the service quality beyond costumer expectations. The selected quality technique should be appropriate to the company's culture and should be sufficient for carry out targeted improvement; this will enhance the company’s superiority in market place.For this purpose, Lean Six Sigma methods are one of the important methods being used today as an intensive use of statistical tools and techniques. Lean Six Sigma methods can be implemented in almost all sectors and successful gains can be obtained. Lean Six Sigma has wide range application in the world. Most applications are successful, while some of them are failed. In this study, reasons for unsuccessful Lean Six Sigma projects are examined. The way to convert unsuccessful project into successful project are suggested. Some solutions are carried out for this purpose.

  11. MicroRNA categorization using sequence motifs and k-mers.

    Yousef, Malik; Khalifa, Waleed; Acar, İlhan Erkin; Allmer, Jens

    2017-03-14

    Post-transcriptional gene dysregulation can be a hallmark of diseases like cancer and microRNAs (miRNAs) play a key role in the modulation of translation efficiency. Known pre-miRNAs are listed in miRBase, and they have been discovered in a variety of organisms ranging from viruses and microbes to eukaryotic organisms. The computational detection of pre-miRNAs is of great interest, and such approaches usually employ machine learning to discriminate between miRNAs and other sequences. Many features have been proposed describing pre-miRNAs, and we have previously introduced the use of sequence motifs and k-mers as useful ones. There have been reports of xeno-miRNAs detected via next generation sequencing. However, they may be contaminations and to aid that important decision-making process, we aimed to establish a means to differentiate pre-miRNAs from different species. To achieve distinction into species, we used one species' pre-miRNAs as the positive and another species' pre-miRNAs as the negative training and test data for the establishment of machine learned models based on sequence motifs and k-mers as features. This approach resulted in higher accuracy values between distantly related species while species with closer relation produced lower accuracy values. We were able to differentiate among species with increasing success when the evolutionary distance increases. This conclusion is supported by previous reports of fast evolutionary changes in miRNAs since even in relatively closely related species a fairly good discrimination was possible.

  12. Empirical testing of selected critical success factors in CRM implementation projects - A study of SMEs in the B2B sector

    Röschmann, Kathrin; Ziyadullaeva, Muhayyo

    2011-01-01

    Purpose:The purpose of this thesis is to describe and analyze critical success factors of CRM implementation projects with a special focus on SME’s in the B2B sector.  Method: This study is based on quantitative research using survey method.  Target Audience: SMEs of B2B business, which are planning to implement a CRM system Academic audience, which is interested in CRM implementation with focus on SME.  Conclusion: There are various critical success factors in CRM implementation projects and...

  13. Synopsis of Past Stimulation Methods in Enhanced (Engineered) Geothermal Systems, Boreholes, and Existing Hydrothermal Systems with Success Analysis and Recommendations for Future Projects

    Broadhurst, T.; Mattson, E.

    2017-12-01

    Enhanced geothermal systems (EGS) are gaining in popularity as a technology that can be used to increase areas for geothermal resource procurement. One of the most important factors in the success of an EGS system is the success of the subsurface reservoir that is used for fluid flow and heat mining through advection. There are numerous challenges in stimulating a successful reservoir, including maintaining flow rates, minimizing leak off, preventing short-circuiting, and reducing the risk of microseismicity associated with subsurface activity. Understanding past examples of stimulation can be invaluable in addressing these challenges. This study provides an overview of stimulation methods that have been employed in EGS systems from 1974-2017. We include all geothermal reservoirs and demonstration projects that have experienced hydrofracturing, chemical stimulation, and induced thermal stress for a comprehensive list. We also examine different metrics and measures of success in geothermal reservoir stimulation to draw conclusions and provide recommendations for future projects. Multiple project characteristics are reported including geologic setting, stress conditions, reservoir temperature, injection specifics, resulting microseismicity, and overall project goals. Insight into optimal and unproductive stimulation methods is crucial to conserving mental capital, utilizing project funding, and ensuring EGS technology advances as efficiently as possible.

  14. MERS Coronavirus Neutralizing Antibodies in Camels, Eastern Africa, 1983-1997

    Müller, Marcel A; Corman, Victor Max; Jores, Joerg; Meyer, Benjamin; Younan, Mario; Liljander, Anne; Bosch, Berend-Jan; Lattwein, Erik; Hilali, Mosaad; Musa, Bakri E; Bornstein, Set; Drosten, Christian

    2014-01-01

    To analyze the distribution of Middle East respiratory syndrome coronavirus (MERS-CoV)-seropositive dromedary camels in eastern Africa, we tested 189 archived serum samples accumulated during the past 30 years. We identified MERS-CoV neutralizing antibodies in 81.0% of samples from the main

  15. Molecular dynamics of Middle East Respiratory Syndrome Coronavirus (MERS CoV) fusion heptad repeat trimers

    Kandeel, Mahmoud; Al-Taher, Abdulla; Li, Huifang; Schwingenschlö gl, Udo; Alnazawi, Mohamed

    2018-01-01

    Structural studies related to Middle East Respiratory Syndrome Coronavirus (MERS CoV) infection process are so limited. In this study, molecular dynamics (MD) simulation was carried out to unravel changes in the MERS CoV heptad repeat domains (HRs

  16. Nordic Winter and Cold: Their Correspondence with Tomas Tranströmer's Poetry

    Hosian, Mohammad Akbar

    2015-01-01

    The Nobel Prize winning poet Tomas Tranströmer was born and bred in Sweden, a remarkably Scandinavian country. Topographically, Scandinavian countries are locations of extreme cold and snowing. This distinguishing climatic condition has had a dominant influence and impact on almost all Scandinavian art and literature, including Tomas Tranströmer's…

  17. Self-esteem, Motivation, and Emotional Intelligence: Three Factors that influence the Successful Design of a Life Project of Middle-school Young Students

    Andrea Magdalena Lomelí-Parga

    2016-05-01

    Full Text Available The purpose of this research study is to depict the factors that allow young people to effectively carry out their life projects by planning short, mid, and long term goals. The population sample participating in this study was comprised of middle and high school students. This research was executed using mixed methods in order to identify the determining factors for young people who plan to have success in facing the daily life challenges, as well as today’s society demands, through a solid construction of their private vision of the future. The results of this project determine that the features which allow the conclusion of students’ life projects are closely related with a high self-esteem and motivation, as well as some emotional intelligence that allow students to visualize a successful personal and professional future.

  18. School Mathematics Leaders' Perceptions of Successes and Challenges of Their Leadership Role within a Mathematics Improvement Project

    Sexton, Matt; Downton, Ann

    2014-01-01

    The mathematics curriculum leader plays an important role in leading the mathematics curriculum in primary schools. They experience successes and face challenges associated with this leadership role. The perceptions that 25 mathematics leaders held about the successes and challenges they experienced whilst participating in a school mathematics…

  19. The Forest Service, Rocky Mountain Research Station's Southwestern Borderlands Ecosystem Management Project: building on ten years of success [Abstract

    Gerald J. Gottfried; Carleton B. Edminster

    2005-01-01

    The USDA Forest Service initiated the Southwestern Borderlands Ecosystem Management Project in 1994. The Project concentrates on the unique, relatively unfragmented landscape of exceptional biological diversity in southeastern Arizona and southwestern New Mexico. Its mission is to: "Contribute to the scientific basis for developing and implementing a comprehensive...

  20. Description and Evaluation of the ARIES Project: Achieving Rehabilitation, Individualized Education, and Employment Success for Adolescents with Emotional Disturbance.

    Bullis, Michael; Moran, Tim; Benz, Michael R.; Todis, Bonnie; Johnson, Michael D.

    2002-01-01

    A cooperative project of the University of Oregon and Springfield, Oregon, School District provided adolescents with emotional disturbances with a transition specialist to develop a service delivery plan and access services. Self-determination, competitive vocational placements, and educational support were emphasized. Project impact on…

  1. Building Ecological and Community Resilience and Measuring Success of the Department of Interior Hurricane Sandy Resilience Projects

    Taylor, S. M.; Worman, S. L.; Bennett, R.; Bassow, A.

    2017-12-01

    The Department of the Interior (DOI) partnered with the National Fish and Wildlife Foundation (NFWF) to administer an external funding competition to support coastal resilience projects in the region affected by Hurricane Sandy. The projects complement the DOI Bureau-led projects, but are led by state and local governments, universities, non-profits, community groups, tribes, and other non-Federal entities. In total, the Hurricane Sandy Resilience Program invested over $750 million in approximately 180 projects to repair damage and improve the resilience of habitats, communities and infrastructure to future storms and sea level rise. Project activities include waterway connection and opening, living shoreline, marsh restoration, community resilience planning, data/mapping/modeling, and beach and dune restoration. DOI and NFWF initiated a resilience assessment in 2015 to evaluate the impact of this investment. The assessment began by clarifying the program's resilience goals and the development of ecological and socio-economic metrics across the project activities. Using these metrics, the evaluation is assessing the ecological and community outcomes, cost effectiveness of activities, improved scientific understanding, and temporal and spatial scaling of benefits across resilience activities. Recognizing the unique opportunity afforded by the scale and distribution of projects, NFWF and DOI have invested in monitoring through 2024 to better understand how these projects perform over time. This presentation will describe the evaluation questions, approach, long-term monitoring, online metrics portal, and findings to date.

  2. Success Lies in the Eye of the Beholder: The Mismatch Between Perceived and Real IT Project Management Performance

    Neves, F.G.; Borgman, H.; Heier, H.; Bui, T.X.; Sprague, R.H.

    2016-01-01

    This study explores the divergence between traditional IT project management performance criteria such as adherence to functionality, schedule and cost, and perceived project management performance. Based on a literature survey, five propositions are derived and subsequently used to guide in-depth

  3. A 7-mer knowledge-based potential for detecting native protein structures from decoys

    Røgen, Peter

    for faster sampling methods. Background: The C-alpha atoms define a polygonal curve in 3-space which is smoothened by the method presented in [1] and is illustrated below. The geometry of a 7-mer is described by two numbers that describe how stretched and curved the smoothening of the 7-mer is. These two...... numbers are called length and distance excess, c.f. [2], and give one point in the length - distance excess - plane, LDE-plane. Method: Given a sequence of amino acids, we break it down to all its 7-mers and search a database of known 3d-structures for similar 7-mer sequences. For the query 7-mer we...... define an energy function in the LDE-plane. This energy is given by the 7-mer found and depends linearly on some design parameters. The energy function of the full query sequence, F, is then a sum over all 7-mers. For a protein P and a decoy D we ideally want F(D)-F(P)=constant.RMSD( D , P ), where 0...

  4. 28-mer Fragment Derived from Enterocin CRL35 Displays an Unexpected Bactericidal Effect on Listeria Cells.

    Masias, Emilse; Sanches, Paulo R S; Dupuy, Fernando G; Acuna, Leonardo; Bellomio, Augusto; Cilli, Eduardo; Saavedra, Lucila; Minahk, Carlos

    2015-01-01

    Two shorter peptides derived from enterocin CRL35, a 43-mer bacteriocin, were synthesized i.e. the N-terminal fragment spanning from residues 1 to 15, and a 28-mer fragment that represents the C-terminal of enterocin CRL35, the residues 16 to 43. The separate peptides showed no activity when combined. On one hand, the 28-mer peptide displayed an unpredicted antimicrobial activity. On the other, 15- mer peptide had no consistent anti-Listeria effect. The dissociation constants calculated from experimental data indicated that all peptides could bind at similar extent to the sensitive cells. However, transmembrane electrical potential was not dissipated to the same level by the different peptides; whereas the full-length and the C-terminal 28-mer fragment induced almost full dissipation, 15-mer fragment produced only a slow and incomplete effect. Furthermore, a different interaction of each peptide with membranes was demonstrated based on studies carried out with liposomes, which led us to conclude that activity was related to structure rather than to net positive charges. These results open up the possibility of designing new peptides based on the 28-mer fragment with enhanced activity, which would represent a promising approach for combating Listeria and other pathogens.

  5. Public perception of an ecological rehabilitation project in inland river basins in northern China: Success or failure.

    Feng, Qi; Miao, Zheng; Li, Zongxing; Li, Jianguo; Si, Jianhua; S, Yonghong; Chang, Zongqiang

    2015-05-01

    The need for environmental protection challenges societies to deal with difficult problems because strategies designed by scientists to protect the environment often create negative effects on impoverished local residents. We investigated the effects of China's national and regional policies related to environmental protection and rehabilitation projects in inland river basins, by studying the effect of projects in the Heihe and Shiyang river basins, in northwest China. Interviews and surveys were conducted at 30 sites in the lower reaches of these two arid basins, an area that has experienced severe ecological degradation. The survey results show the ecological rehabilitation projects adversely affected the livelihoods of 70.35% of foresters, 64.89% of farmers and 62.24% of herders in the Minqing region in the lower Shiyang River Basin; also, the projects negatively affected 51.9% of residents in the Ejin Qi in the lower Heihe River Basin. This caused 16.33% of foresters, 39.90% of farmers and 45.32% of herders in the Minqing region to not support the project and 37.5% of residents in the Ejin Qi region said they will deforest and graze again after the project ends. The negative impacts of the policies connected to the projects cause these attitudes. The projects prohibit felling and grazing and require residents to give up groundwater mining; this results in a great amount of uncompensated economic loss to them. Extensive survey data document the concerns of local residents, concerns that are supported by the calculation of actual incomes. In addition, the surveys results show poorer interviewees believe the projects greatly affected their livelihoods. While citizens in this region support environment protection work, the poor require considerable assistance if one expects them to support this type of work. Governmental assistance can greatly improve their living conditions, and hence encourage them to participate in and support the implementation of the projects

  6. The receptor binding domain of MERS-CoV: The dawn of vaccine and treatment development

    Nan Zhou

    2014-03-01

    Full Text Available The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV is becoming another “SARS-like” threat to the world. It has an extremely high death rate (∼50% as there is no vaccine or efficient therapeutics. The identification of the structures of both the MERS-CoV receptor binding domain (RBD and its complex with dipeptidyl peptidase 4 (DPP4, raises the hope of alleviating this currently severe situation. In this review, we examined the molecular basis of the RBD-receptor interaction to outline why/how could we use MERS-CoV RBD to develop vaccines and antiviral drugs.

  7. Dynamic Cost-Contingency Management: A Method for Reducing Project Costs While Increasing the Probability of Success

    Kujawski, Edouard

    2007-01-01

    In the real world, "Money Allocated is Money Spent" (MAIMS). As a consequence, cost underruns are rarely available to protect against cost overruns, while task overruns are passed on to the total project cost...

  8. The Environmental Health/Home Safety Education Project: a successful and practical U.S.-Mexico border initiative.

    Forster-Cox, Susan C; Mangadu, Thenral; Jacquez, Benjamín; Fullerton, Lynne

    2010-05-01

    The Environmental Health/Home Safety Education Project (Proyecto de Salud Ambiental y Seguridad en el Hogar) has been developed in response to a wide array of severe and often preventable environmental health issues occurring in and around homes on the U.S.-Mexico border. Utilizing well-trained community members, called promotoras , homes are visited and assessed for potential environmental hazards, including home fire and food safety issues. Data analyzed from project years 2002 to 2005 shows a significant impact in knowledge levels and initial behavior change among targeted participants as it relates to fire and food safety issues. Since the initiation of the project in 1999, hundreds of participants have improved their quality of life by making their homes safer. The project has proven to be sustainable, replicable, flexible, and attractive to funders.

  9. Final Verification Success Story Using the Triad Approach at the Oak Ridge National Laboratory's Melton Valley Soils and Sediment Project

    King, D.A.; Haas, D.A.; Cange, J.B.

    2006-01-01

    The United States Environmental Protection Agency recently published guidance on the Triad approach, which supports the use of smarter, faster, and better technologies and work strategies during environmental site assessment, characterization, and cleanup. The Melton Valley Soils and Sediment Project (Project) at the Oak Ridge National Laboratory embraced this three-pronged approach to characterize contaminants in soil/sediment across the 1000-acre Melton Valley Watershed. Systematic Project Planning is the first of three prongs in the Triad approach. Management initiated Project activities by identifying key technical personnel, included regulators early in the planning phase, researched technologies, and identified available resources necessary to meet Project objectives. Dynamic Work Strategies is the second prong of the Triad approach. Core Team members, including State and Federal regulators, helped develop a Sampling and Analysis Plan that allowed experienced field managers to make real-time, in-the-field decisions and, thus, to adjust to conditions unanticipated during the planning phase. Real-time Measurement Technologies is the third and last prong of the Triad approach. To expedite decision-making, the Project incorporated multiple in-field technologies, including global positioning system equipment integrated with field screening instrumentation, magnetometers for utility clearance, and an on-site gamma spectrometer (spec) for rapid contaminant speciation and quantification. As a result of a relatively complex but highly efficient program, a Project field staff of eight collected approximately 1900 soil samples for on-site gamma spec analysis (twenty percent were also shipped for off-site analyses), 4.7 million gamma radiation measurements, 1000 systematic beta radiation measurements, and 3600 systematic dose rate measurements between July 1, 2004, and October 31, 2005. The site database previously contained results for less than 500 soil samples dating

  10. Use of the Theoretical Domains Framework to evaluate factors driving successful implementation of the Accelerated Chest pain Risk Evaluation (ACRE) project.

    Skoien, Wade; Page, Katie; Parsonage, William; Ashover, Sarah; Milburn, Tanya; Cullen, Louise

    2016-10-12

    The translation of healthcare research into practice is typically challenging and limited in effectiveness. The Theoretical Domains Framework (TDF) identifies 12 domains of behaviour determinants which can be used to understand the principles of behavioural change, a key factor influencing implementation. The Accelerated Chest pain Risk Evaluation (ACRE) project has successfully translated research into practice, by implementing an intervention to improve the assessment of low to intermediate risk patients presenting to emergency departments (EDs) with chest pain. The aims of this paper are to describe use of the TDF to determine which factors successfully influenced implementation and to describe use of the TDF as a tool to evaluate implementation efforts and which domains are most relevant to successful implementation. A 30-item questionnaire targeting clinicians was developed using the TDF as a guide. Questions encompassed ten of the domains of the TDF: Knowledge; Skills; Social/professional role and identity; Beliefs about capabilities; Optimism; Beliefs about consequences; Intentions; Memory, attention and decision processes; Environmental context and resources; and Social influences. Sixty-three of 176 stakeholders (36 %) responded to the questionnaire. Responses for all scales showed that respondents were highly favourable to all aspects of the implementation. Scales with the highest mean responses were Intentions, Knowledge, and Optimism, suggesting that initial education and awareness strategies around the ACRE project were effective. Scales with the lowest mean responses were Environmental context and resources, and Social influences, perhaps highlighting that implementation planning could have benefitted from further consideration of the factors underlying these scales. The ACRE project was successful, and therefore, a perfect case study for understanding factors which drive implementation success. The overwhelmingly positive response suggests that it

  11. Project Career: An individualized postsecondary approach to promoting independence, functioning, and employment success among students with traumatic brain injuries.

    Minton, Deborah; Elias, Eileen; Rumrill, Phillip; Hendricks, Deborah J; Jacobs, Karen; Leopold, Anne; Nardone, Amanda; Sampson, Elaine; Scherer, Marcia; Gee Cormier, Aundrea; Taylor, Aiyana; DeLatte, Caitlin

    2017-09-14

    Project Career is a five-year interdisciplinary demonstration project funded by NIDILRR. It provides technology-driven supports, merging Cognitive Support Technology (CST) evidence-based practices and rehabilitation counseling, to improve postsecondary and employment outcomes for veteran and civilian undergraduate students with traumatic brain injury (TBI). Provide a technology-driven individualized support program to improve career and employment outcomes for students with TBI. Project staff provide assessments of students' needs relative to assistive technology, academic achievement, and career preparation; provide CST training to 150 students; match students with mentors; provide vocational case management; deliver job development and placement assistance; and maintain an electronic portal regarding accommodation and career resources. Participating students receive cognitive support technology training, academic enrichment, and career preparatory assistance from trained professionals at three implementation sites. Staff address cognitive challenges using the 'Matching Person with Technology' assessment to accommodate CST use (iPad and selected applications (apps)). JBS International (JBS) provides the project's evaluation. To date, 117 students participate with 63% report improved life quality and 75% report improved academic performance. Project Career provides a national model based on best practices for enabling postsecondary students with TBI to attain academic, employment, and career goals.

  12. Dromedary camels and the transmission of Middle East Respiratory Syndrome Coronavirus (MERS-CoV)

    Hemida, Maged G; Elmoslemany, Ahmed; Al-Hizab, Fahad; Alnaeem, Abdulmohsen; Almathen, Faisal; Faye, Bernard; Chu, Daniel KW; Perera, Ranawaka A; Peiris, Malik

    2015-01-01

    Middle East respiratory syndrome coronavirus (MERS-CoV) is an existential threat to global public health. The virus has been repeatedly detected in dromedary camels (Camelus dromedarius). Adult animals in many countries in the Middle East as well as in North and East Africa showed high (>90%) sero-prevalence to the virus. MERS-CoV isolated from dromedaries is genetically and phenotypically similar to viruses from humans. We summarise current understanding of the ecology of MERS-CoV in animals and transmission at the animal-human interface. We review aspects of husbandry, animal movements and trade and the use and consumption of camel dairy and meat products in the Middle East that may be relevant to the epidemiology of MERS. We also highlight the gaps in understanding the transmission of this virus in animals and from animals to humans. PMID:26256102

  13. MER 1 MARS NAVCAM 3 RADIOMETRIC RDR SCI V1.0

    National Aeronautics and Space Administration — This data set contains radiometrically calibrated MER-1 Navcam data. The calibration has removed bias, dark current, and flatfield effects from the raw Navcam data,...

  14. Lessons from overseas; Lecons d'outre-mer

    Boucher, I. [Quebec Ministere des Affaires Municipales et des Regions du Quebec, Quebec, PQ (Canada)

    2006-10-01

    landscapes. Also, in both countries, communication with citizen groups, organizations and decision makers proved to be vital. This article also stated that this development framework is used in Germany, Australia and Switzerland, and appears to be the key to success in managing wind turbine array projects. It was concluded that in matters of energy, wind power is a sustainable option, but should not interfere with the aesthetics of local landscapes. 8 refs., 5 figs.

  15. General document environmental impact report (m.e.r.) oil and gas exploitation industry. Update and supplement of the general document; Generiek document m.e.r. offshore olie- en gaswinningsindustrie. Update en aanvulling van het generiek document environmental impact report (m.e.r.) offshore, 1999

    NONE

    2008-04-15

    The generic environmental impact assessment (EIA or MER in Dutch) in 1999 is intended to serve as a template for specific environmental impact assessments for oil and gas exploitation projects at sea. Since 1999, a number of innovations and changes were implemented. Particularly in offshore technologies and regulations new insights and ideas came up in recent years. Therefore the existing generic document has to be updated with new information, relevant in the preparation of specific environmental impact assessments in the offshore oil and gas exploitation industry in the Dutch part of the Continental Shelf [Dutch] De generieke milieu effect rapportage (MER) uit 1999 is bedoeld om te dienen als een sjabloon voor specifieke Milieueffectrapportages bij olie- en gaswinningprojecten op zee. Sinds 1999 is een aantal vernieuwingen en veranderingen doorgevoerd. Met name in offshore technologieen en wet- en regelgeving zijn de afgelopen jaren nieuwe inzichten en ideeen ontstaan. Hierdoor is de wens ontstaan om het bestaande generieke document aan te vullen met nieuwe informatie die relevant is voor het opstellen van specifieke Milieueffectrapportages in de offshore olie- en gaswinningsindustrie op het Nederlands deel van het Continentaal Plat.

  16. A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines.

    Lanying Du

    Full Text Available An emerging respiratory infectious disease with high mortality, Middle East respiratory syndrome (MERS, is caused by a novel coronavirus (MERS-CoV. It was first reported in 2012 in Saudi Arabia and has now spread to eight countries. Development of effective therapeutics and vaccines is crucial to save lives and halt the spread of MERS-CoV. Here, we show that a recombinant protein containing a 212-amino acid fragment (residues 377-588 in the truncated receptor-binding domain (RBD: residues 367-606 of MERS-CoV spike (S protein fused with human IgG Fc fragment (S377-588-Fc is highly expressed in the culture supernatant of transfected 293T cells. The purified S377-588-Fc protein efficiently binds to dipeptidyl peptidase 4 (DPP4, the receptor of MERS-CoV, and potently inhibited MERS-CoV infection, suggesting its potential to be further developed as a therapeutic modality for treating MERS-CoV infection and saving the patients' lives. The recombinant S377-588-Fc is able to induce in the vaccinated mice strong MERS-CoV S-specific antibodies, which blocks the binding of RBD to DPP4 receptor and effectively neutralizes MERS-CoV infection. These findings indicate that this truncated RBD protein shows promise for further development as an effective and safe vaccine for the prevention of MERS-CoV infection.

  17. Rapid detection of MERS coronavirus-like viruses in bats: pote1ntial for tracking MERS coronavirus transmission and animal origin.

    Woo, Patrick C Y; Lau, Susanna K P; Chen, Yixin; Wong, Emily Y M; Chan, Kwok-Hung; Chen, Honglin; Zhang, Libiao; Xia, Ningshao; Yuen, Kwok-Yung

    2018-03-07

    Recently, we developed a monoclonal antibody-based rapid nucleocapsid protein detection assay for diagnosis of MERS coronavirus (MERS-CoV) in humans and dromedary camels. In this study, we examined the usefulness of this assay to detect other lineage C betacoronaviruses closely related to MERS-CoV in bats. The rapid MERS-CoV nucleocapsid protein detection assay was tested positive in 24 (88.9%) of 27 Tylonycteris bat CoV HKU4 (Ty-BatCoV-HKU4) RNA-positive alimentary samples of Tylonycteris pachypus and 4 (19.0%) of 21 Pipistrellus bat CoV HKU5 (Pi-BatCoV-HKU5) RNA-positive alimentary samples of Pipistrellus abramus. There was significantly more Ty-BatCoV-HKU4 RNA-positive alimentary samples than Pi-BatCoV-HKU5 RNA-positive alimentary samples that were tested positive by the rapid MERS-CoV nucleocapsid protein detection assay (P < 0.001 by Chi-square test). The rapid assay was tested negative in all 51 alimentary samples RNA-positive for alphacoronaviruses (Rhinolophus bat CoV HKU2, Myotis bat CoV HKU6, Miniopterus bat CoV HKU8 and Hipposideros batCoV HKU10) and 32 alimentary samples positive for lineage B (SARS-related Rhinolophus bat CoV HKU3) and lineage D (Rousettus bat CoV HKU9) betacoronaviruses. No significant difference was observed between the viral loads of Ty-BatCoV-HKU4/Pi-BatCoV-HKU5 RNA-positive alimentary samples that were tested positive and negative by the rapid test (Mann-Witney U test). The rapid MERS-CoV nucleocapsid protein detection assay is able to rapidly detect lineage C betacoronaviruses in bats. It detected significantly more Ty-BatCoV-HKU4 than Pi-BatCoV-HKU5 because MERS-CoV is more closely related to Ty-BatCoV-HKU4 than Pi-BatCoV-HKU5. This assay will facilitate rapid on-site mass screening of animal samples for ancestors of MERS-CoV and tracking transmission in the related bat species.

  18. Pol II promoter prediction using characteristic 4-mer motifs: a machine learning approach

    Shoyaib Mohammad

    2008-10-01

    Full Text Available Abstract Background Eukaryotic promoter prediction using computational analysis techniques is one of the most difficult jobs in computational genomics that is essential for constructing and understanding genetic regulatory networks. The increased availability of sequence data for various eukaryotic organisms in recent years has necessitated for better tools and techniques for the prediction and analysis of promoters in eukaryotic sequences. Many promoter prediction methods and tools have been developed to date but they have yet to provide acceptable predictive performance. One obvious criteria to improve on current methods is to devise a better system for selecting appropriate features of promoters that distinguish them from non-promoters. Secondly improved performance can be achieved by enhancing the predictive ability of the machine learning algorithms used. Results In this paper, a novel approach is presented in which 128 4-mer motifs in conjunction with a non-linear machine-learning algorithm utilising a Support Vector Machine (SVM are used to distinguish between promoter and non-promoter DNA sequences. By applying this approach to plant, Drosophila, human, mouse and rat sequences, the classification model has showed 7-fold cross-validation percentage accuracies of 83.81%, 94.82%, 91.25%, 90.77% and 82.35% respectively. The high sensitivity and specificity value of 0.86 and 0.90 for plant; 0.96 and 0.92 for Drosophila; 0.88 and 0.92 for human; 0.78 and 0.84 for mouse and 0.82 and 0.80 for rat demonstrate that this technique is less prone to false positive results and exhibits better performance than many other tools. Moreover, this model successfully identifies location of promoter using TATA weight matrix. Conclusion The high sensitivity and specificity indicate that 4-mer frequencies in conjunction with supervised machine-learning methods can be beneficial in the identification of RNA pol II promoters comparative to other methods. This

  19. Critical Spacecraft-to-Earth Communications for Mars Exploration Rover (MER) entry, descent and landing

    Hurd, William J.; Estabrook, Polly; Racho, Caroline S.; Satorius, Edgar H.

    2002-01-01

    For planetary lander missions, the most challenging phase of the spacecraft to ground communications is during the entry, descent, and landing (EDL). As each 2003 Mars Exploration Rover (MER) enters the Martian atmosphere, it slows dramatically. The extreme acceleration and jerk cause extreme Doppler dynamics on the X-band signal received on Earth. When the vehicle slows sufficiently, the parachute is deployed, causing almost a step in deceleration. After parachute deployment, the lander is lowered beneath the parachute on a bridle. The swinging motion of the lander imparts high Doppler dynamics on the signal and causes the received signal strength to vary widely, due to changing antenna pointing angles. All this time, the vehicle transmits important health and status information that is especially critical if the landing is not successful. Even using the largest Deep Space Network antennas, the weak signal and high dynamics render it impossible to conduct reliable phase coherent communications. Therefore, a specialized form of frequency-shift-keying will be used. This paper describes the EDL scenario, the signal conditions, the methods used to detect and frequency-track the carrier and to detect the data modulation, and the resulting performance estimates.

  20. "Adotta scienza e arte nella tua classe": The results of a successfully teaching project which combines science with art⋆

    Giansanti, S.

    2015-03-01

    The project called Adotta scienza e arte nella tua classe ("Adopt Science and Art in your class"), on the interconnection between science and art, has been addressed to the Italian secondary middle and high school involving more than 200 teachers and about 2200 students. The main purpose of this project is to make the young students aware of the strong link between science and art is a unique cultural and interdisciplinary occasion. To reach this goal, the Adotta project asked students to produce an artwork inspired by the interpretation of a quotation among a hundred commented quotes by physicists, mathematicians, scientist, writers, artists, accompanied by an original short sentence written by students themselves. More than 1000 artworks have been produced and collected in two galleries on Facebook. From their analysis emerges the students' feeling about science, which is usually associated to human brain, based on mathematical laws and related to technological progress, but it is also a powerful tool that should be responsibly used. This project also valorizes teachers' role in scientific education through activities that encourage students to recognize science in every aspect of their lives.

  1. Water on Mars: Evidence from MER Mission Results

    Landis, Geoffrey A.

    2004-01-01

    The Viking and the Mars Exploration Rover missions observed that the surface of Mars is encrusted by a thinly cemented layer, or "duricrust". Elemental analyzes at five sites on Mars show that these soils have sulfur content and chlorine content consistent with the presence of sulfates and halides as mineral cements. The soil is highly enriched in the salt-forming elements compared with rock. Analysis of the soil cementation indicates some features which may be evidence of liquid water. At both MER sites, duricrust textures revealed by the Microscopic Imager show features including the presence of fine sand-sized grains, some of which may be aggregates of fine silt and clay, surrounded by a pervasive light colored material that is associated with microtubular structures and networks of microfractures. Stereo views of undisturbed duricrust surfaces reveal rugged microrelief between 2-3 mm and minimal loose material. Comparisons of microscopic images of duricrust soils obtain before and after placement of the Mossbauer spectrometer indicate differing degrees of compaction and cementation. Two models of a transient water hypothesis are offered, a "top down" hypothesis that emphasizes the surface deposition of frost, melting and downward migration of liquid water and a "bottom up" alternative that proposes the presence of interstitial ice/brine, with the upward capillary migration of liquid water. The viability of both of these models ultimately hinges on the availability of seasonally transient liquid water for brief periods.

  2. Redefining Tactical Operations for MER Using Cloud Computing

    Joswig, Joseph C.; Shams, Khawaja S.

    2011-01-01

    The Mars Exploration Rover Mission (MER) includes the twin rovers, Spirit and Opportunity, which have been performing geological research and surface exploration since early 2004. The rovers' durability well beyond their original prime mission (90 sols or Martian days) has allowed them to be a valuable platform for scientific research for well over 2000 sols, but as a by-product it has produced new challenges in providing efficient and cost-effective tactical operational planning. An early stage process adaptation was the move to distributed operations as mission scientists returned to their places of work in the summer of 2004, but they would still came together via teleconference and connected software to plan rover activities a few times a week. This distributed model has worked well since, but it requires the purchase, operation, and maintenance of a dedicated infrastructure at the Jet Propulsion Laboratory. This server infrastructure is costly to operate and the periodic nature of its usage (typically heavy usage for 8 hours every 2 days) has made moving to a cloud based tactical infrastructure an extremely tempting proposition. In this paper we will review both past and current implementations of the tactical planning application focusing on remote plan saving and discuss the unique challenges present with long-latency, distributed operations. We then detail the motivations behind our move to cloud based computing services and as well as our system design and implementation. We will discuss security and reliability concerns and how they were addressed

  3. Nutrient availability at Mer Bleue bog measured by PRSTM probes

    Wang, M.; Moore, T. R.; Talbot, J.

    2015-12-01

    Bogs, covering ~0.7 million km2 in Canada, store a large amount of C and N. As nutrient deficient ecosystems, it's critical to examine the nutrient availabilities and seasonal dynamics. We used Plant Root Simulators (PRSTM) at Mer Bleue bog to provide some baseline data on nutrient availability and its variability. In particular, we focused on ammonium, nitrate, phosphate, calcium, magnesium and potassium, iron, sulphate and aluminum. We placed PRS probes at a depth of 5 - 15 cm in pristine plots and plots with long term N, P and K fertilization for 4 weeks and determined the availability of these nutrients, from spring through to fall. Probes were also placed beneath the water table in hummock and hollow microtopography and along a transect including part of the bog which had been drained through the creation of a ditch 80 years ago. The result showed that there was limited available ammonium, nitrate and phosphate in the bog, the seasonal variation of nutrient availabilities probably due to mineralization, an increase in the availability of some nutrients between different water table depths or as a result of drainage, and the relative availability of nutrients compared to the input from fertilization. We suggest that PRS probes could be a useful tool to examine nutrient availability and dynamics in wetlands, with careful consideration of installing condition, for example, proper exposure period, depth relative to water table etc.

  4. The impact of multichannel microelectrode recording (MER) in deep brain stimulation of the basal ganglia.

    Kinfe, Thomas M; Vesper, Jan

    2013-01-01

    Deep brain stimulation (DBS) of the basal ganglia (Ncl. subthalamicus, Ncl. ventralis intermedius thalami, globus pallidus internus) has become an evidence-based and well-established treatment option in otherwise refractory movement disorders. The Ncl. subthalamicus (STN) is the target of choice in Parkinson's disease.However, a considerable discussion is currently ongoing with regard to the necessity for micro-electrode recording (MER) in DBS surgery.The present review provides an overview on deep brain stimulation and (MER) of the STN in patients with Parkinson's disease. Detailed description is given concerning the multichannel MER systems nowadays available for DBS of the basal ganglia, especially of the STN, as a useful tool for target refinement. Furthermore, an overview is given of the historical aspects, spatial mapping of the STN by MER, and its impact for accuracy and precision in current functional stereotactic neurosurgery.The pros concerning target refinement by MER means on the one hand, and cons including increased bleeding risk, increased operation time, local or general anesthesia, and single versus multichannel microelectrode recording are discussed in detail. Finally, the authors favor the use of MER with intraoperative testing combined with imaging to achieve a more precise electrode placement, aiming to ameliorate clinical outcome in therapy-resistant movement disorders.

  5. Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection - clinicopathological and ultrastructural study.

    Alsaad, Khaled O; Hajeer, Ali H; Al Balwi, Mohammed; Al Moaiqel, Mohammed; Al Oudah, Nourah; Al Ajlan, Abdulaziz; AlJohani, Sameera; Alsolamy, Sami; Gmati, Giamal E; Balkhy, Hanan; Al-Jahdali, Hamdan H; Baharoon, Salim A; Arabi, Yaseen M

    2018-02-01

    The pathogenesis, viral localization and histopathological features of Middle East respiratory syndrome - coronavirus (MERS-CoV) in humans are not described sufficiently. The aims of this study were to explore and define the spectrum of histological and ultrastructural pathological changes affecting various organs in a patient with MERS-CoV infection and represent a base of MERS-CoV histopathology. We analysed the post-mortem histopathological findings and investigated localisation of viral particles in the pulmonary and extrapulmonary tissue by transmission electron microscopic examination in a 33-year-old male patient of T cell lymphoma, who acquired MERS-CoV infection. Tissue needle biopsies were obtained from brain, heart, lung, liver, kidney and skeletal muscle. All samples were collected within 45 min from death to reduce tissue decomposition and artefact. Histopathological examination showed necrotising pneumonia, pulmonary diffuse alveolar damage, acute kidney injury, portal and lobular hepatitis and myositis with muscle atrophic changes. The brain and heart were histologically unremarkable. Ultrastructurally, viral particles were localised in the pneumocytes, pulmonary macrophages, renal proximal tubular epithelial cells and macrophages infiltrating the skeletal muscles. The results highlight the pulmonary and extrapulmonary pathological changes of MERS-CoV infection and provide the first evidence of the viral presence in human renal tissue, which suggests tissue trophism for MERS-CoV in kidney. © 2017 John Wiley & Sons Ltd.

  6. Antibodies against MERS coronavirus in dromedary camels, United Arab Emirates, 2003 and 2013.

    Meyer, Benjamin; Müller, Marcel A; Corman, Victor M; Reusken, Chantal B E M; Ritz, Daniel; Godeke, Gert-Jan; Lattwein, Erik; Kallies, Stephan; Siemens, Artem; van Beek, Janko; Drexler, Jan F; Muth, Doreen; Bosch, Berend-Jan; Wernery, Ulrich; Koopmans, Marion P G; Wernery, Renate; Drosten, Christian

    2014-04-01

    Middle East respiratory syndrome coronavirus (MERS-CoV) has caused an ongoing outbreak of severe acute respiratory tract infection in humans in the Arabian Peninsula since 2012. Dromedary camels have been implicated as possible viral reservoirs. We used serologic assays to analyze 651 dromedary camel serum samples from the United Arab Emirates; 151 of 651 samples were obtained in 2003, well before onset of the current epidemic, and 500 serum samples were obtained in 2013. Recombinant spike protein-specific immunofluorescence and virus neutralization tests enabled clear discrimination between MERS-CoV and bovine CoV infections. Most (632/651, 97.1%) camels had antibodies against MERS-CoV. This result included all 151 serum samples obtained in 2003. Most (389/651, 59.8%) serum samples had MERS-CoV-neutralizing antibody titers >1,280. Dromedary camels from the United Arab Emirates were infected at high rates with MERS-CoV or a closely related, probably conspecific, virus long before the first human MERS cases.

  7. Disease Management Project Breast Cancer in Hesse - 5-Year Survival Data: Successful Model of Intersectoral Communication for Quality Assurance.

    Jackisch, C; Funk, A; König, K; Lubbe, D; Misselwitz, B; Wagner, U

    2014-03-01

    Introduction: The Disease Management Project Breast Cancer (DMP Breast Cancer) was first launched in Hesse in 2004. The project is supported by the health insurance companies in Hesse and the Professional Association of Gynaecologists in Hesse. The aim is to offer structured treatment programmes to all women diagnosed with breast cancer in Hesse by creating intersectoral cooperations between coordinating clinics, associated hospitals and gynaecologists in private practice who registered in the DMP programme. Method: Between 1 January 2005 and 30 June 2011, 13 973 women were enrolled in the DMP programme. Results: After data cleansing, survival rates were calculated for a total of 11 214 women. The 5-year overall survival (OS) rate was 86.3 %; survival rates according to tumour stage on presentation were 92.2 % (pT1) and 82.3 % (pT2), respectively. The impact of steroid hormone receptor status on survival (87.8 % for receptor-positive cancers vs. 78.9 % for receptor-negative cancers) and of age at first diagnosis on survival (≤ 35 years = 91 %) were calculated. Conclusion: The project showed that intersectoral cooperation led to significant improvements in the quality of treatment over time, as measured by quality indicators and outcomes after treatment.

  8. Activities and interim outcomes of a multi-site development project to promote cognitive support technology use and employment success among postsecondary students with traumatic brain injuries.

    Hendricks, Deborah J; Sampson, Elaine; Rumrill, Phillip; Leopold, Anne; Elias, Eileen; Jacobs, Karen; Nardone, Amanda; Scherer, Marcia; Stauffer, Callista

    2015-01-01

    This article describes the activities and interim outcomes of a multi-site development project called Project Career, designed to promote cognitive support technology (CST) use and employment success for college and university students with traumatic brain injuries (TBIs). To obtain early intervention results from participants in Project Career's first 18 months of operation. Fifty-six students with TBI have participated to date across three implementation sites in Massachusetts, Ohio, and West Virginia, with 25 of these participants being military veterans. Descriptive analyses provide information regarding the participants, the barriers they face due to their TBI in obtaining a post-secondary education, and the impact services provided by Project Career have had to date in ameliorating those difficulties. Inferential statistical analyses provide preliminary results regarding program effectiveness. Preliminary results indicate the program is encouraging students to use CST strategies in the form of iPads and cognitive enhancement applications (also known as 'apps'). Significant results indicate participants are more positive, independent, and social; participants have a more positive attitude toward technology after six months in the program; and participants reported significantly improved experiences with technology during their first six months in the program. Participating students are actively preparing for their careers after graduation through a wide range of intensive vocational supports provided by project staff members.

  9. Factors affecting antimicrobial activity of MUC7 12-mer, a human salivary mucin-derived peptide

    Bobek Libuse A

    2007-11-01

    Full Text Available Abstract Background MUC7 12-mer (RKSYKCLHKRCR, a cationic antimicrobial peptide derived from the human low-molecular-weight salivary mucin MUC7, possesses potent antimicrobial activity in vitro. In order to evaluate the potential therapeutic application of the MUC7 12-mer, we examined the effects of mono- and divalent cations, EDTA, pH, and temperature on its antimicrobial activity. Methods Minimal Inhibitory Concentrations (MICs were determined using a liquid growth inhibition assay in 96-well microtiter plates. MUC7 12-mer was added at concentrations of 1.56–50 μM. MICs were determined at three endpoints: MIC-0, MIC-1, and MIC-2 (the lowest drug concentration showing 10%, 25% and 50% of growth, respectively. To examine the effect of salts or EDTA, a checkerboard microdilution technique was used. Fractional inhibitory concentration index (FICi was calculated on the basis of MIC-0. The viability of microbial cells treated with MUC7 12-mer in the presence of sodium or potassium was also determined by killing assay or flow cytometry. Results The MICs of MUC7 12-mer against organisms tested ranged from 6.25–50 μM. For C. albicans, antagonism (FICi 4.5 was observed for the combination of MUC7 12-mer and calcium; however, there was synergism (FICi 0.22 between MUC7 12-mer and EDTA, and the synergism was retained in the presence of calcium at its physiological concentration (1–2 mM. No antagonism but additivity or indifference (FICi 0.55–2.5 was observed for the combination of MUC7 12-mer and each K+, Na+, Mg2+, or Zn2+. MUC7 12-mer peptide (at 25 μM also exerted killing activity in the presence of NaCl, (up to 25 mM for C. albicans and up to 150 mM for E. coli, a physiological concentration of sodium in the oral cavity and serum, respectively and retained candidacidal activity in the presence of KCl (up to 40 mM. The peptide exhibited higher inhibitory activity against C. albicans at pH 7, 8, and 9 than at pH 5 and 6, and temperature up to

  10. Technical and economic aspects of successful nuclear plant construction projects in the U.S. and future prospects

    Braun, C.; Rahn, F.J.

    1986-01-01

    Taken together as stones in a mosaic, the individual successes and failures of various nuclear plant construction programs begin to form a larger picture. Certain prerequisites to good experience become apparent. They are: agreement of need, constancy of purpose, rationalization of vendor/utility organizations, stable regulatory environment and plant standardization. Equally important is a belief that power plant costs can be contained and the commitment to do something about them. A Calvinist approach to spending, namely that costs are preordained and cannot be affected by mere men, is self-defeating. There is no escaping these conclusions nor the need to implement them

  11. A success story of regional projects implemented for the management of marine environment. Turkish experience related to the black sea and the mediterranean sea

    Goktepe, B.G.; Gungor, N.; Gungor, E.; Karakelle, B.

    2004-01-01

    Full text: A wide scope Regional Technical Co-operation Project RER/2/003 'Marine Environmental Assessment of the Black Sea Region' is implemented by the International Atomic Energy Agency (IAEA) in the period 1995-2001. This project was initiated in response to the needs of participating Member States - the six Black Sea coastal countries (Bulgaria, Romania, Ukraine, Russian Federation, Georgia and Turkey) to establish capabilities for reliably assessing radionuclides in the Black Sea environment and applying tracer techniques to marine pollution studies The project has various important aspects: Scientifically; one of the major environmental issue radioactivity pollution is addressed. Technically; laboratory capability for transuranic analysis is being developed. Economically; the reversing the ecological deterioration and developing sustainable uses of the Black Sea and its natural resources is one of the major interests. Politically; responsibility of pollution control and rehabilitation plans of six Black Sea countries are addressed through various convention and declarations. Socio-economically, fisheries and tourism sectors are expected to benefit. Highlights from the joint radioactivity-monitoring program of the project among six Black Sea countries are outlined. Examples from the Turkish monitoring work consist of the routine sampling of seawater, algae, mussels, fish samples and beach sand from the selected stations along the Black Sea coast are presented for illustration. The success of the Black Sea regional project has given rise to a new regional project 'Marine Environmental Assessment of the Mediterranean Region' based on the request of the member countries, which will be initiated in 2005 by the IAEA. The initial phase the project, its objectives and the schedule will be summarized. Key words: marine radioactivity, environmental management, Black Sea, Mediterranean Sea, regional cooperation

  12. Educación Compensatoria. Aprendizaje temprano, éxito posterior (II: Carolina Abecedarian Project . [Compensatory education. Early learning, later success (II: Carolina Abecedarian Project

    Eduardo López López

    2007-01-01

    Full Text Available This is a review study which analyzes research that evaluates the long term effects of an early education program, the Abecedarian Project. The Abecedarian Project (ABC is a preventive compensatory education program for children from 0 to 5 years of high risk mothers. The experimental group (E received an intensive preschool treatment, while the control (C group did not. At five years old, each group was divided into another two groups: Two of these new groups (EE and CE received intensive schooling until the children reached 8 years old, while the other groups (EC and CC received no special treatment. The total sample was measured until each child reached 21 years. The results were as follows: The young adults, treated in the preschool years, had on average significantly higher cognitive test scores, earned higher scores on reading and math tests; they completed more years of education, they were more likely to attend a 4-year college or university, and they were less likely to become teen parents. Furthermore, the mothers of these students were more likely to reach a higher level of instruction and employment. Finally, the article discusses the validity of the study and the factors associated to the benefits (the early beginning, intensity and continuity of the program. Este es un estudio de revisión en el que se analizan las investigaciones que evalúan los efectos a lo largo del tiempo del temprano Abecedarian Project (ABC. El ABC es un programa compensador preventivo de 0-5 años y entresacados de madres de alto riesgo. El grupo experimental (E recibe tratamiento preescolar intensivo, no el control (C. Se prolongó escolarmente hasta los 8 años, subdividiéndose ambos grupos: Dos -EE y CE- recibieron tratamiento intensivo; otros (EC y CC convencional. Fueron medidos hasta los 21. Resultados: Los jóvenes adultos, tratados preescolarmente, mejoraron en rendimiento mental, lector y matemático; alcanzaron mayores instrucción y presencia en

  13. PUBLIC-PRIVATE PARTNERSHIP – THE MOST IMPORTANT MODERN TOOLS OF SUCCESSFUL IMPLEMENTATION OF NATIONAL INVESTMENT PROJECTS

    E. E. Zhukov

    2010-01-01

    Full Text Available Article is devoted to actual problems and prospects of perfection of public private partnership mechanisms at important social and economic investment projects realization. The analysis of foreign practice in the PPP field is carried out. Features of Russian PPP development model are considered. The main difficulties on this way are designated. Such as: absence of the normal competitive environment during the choice of the private partner-investor; absence of the qualified experts in the PPP; imperfect legislative base; corruption of officials, etc. Main offers of perfection of PPP-mechanism in Russia, accounting forthcoming modernization and innovative development of Russian economy are given.

  14. How Long Before NATO Aircraft Carrier Force Projection Capabilities Are Successfully Countered? Some effects of the fiscal crises

    Lučev Josip

    2014-10-01

    Full Text Available Growth and fiscal policy conducive to economic development have been severely jeopardized in most NATO member countries since 2008. In sharp contrast, China has experienced only a relatively slower GDP growth, which it has mitigated with a fiscally expansionary outlook. Under these conditions, when can we expect the politico-military position of NATO to be challenged? This paper surveys amphibious force projection capabilities in six countries: the USA, the UK, France, Russia, India and the People's Republic of China (PRC. An assessment of the current capability for aircraft carrier building and a survey of carrier-related ambitions is undertaken to offer projections of probable aircraft carrier fleets by 2030. The three non-NATO countries are far better positioned to build aircraft carriers than the three NATO members, with China in the lead. Nevertheless, there is a high probability of the continued military dominance of the USA and NATO, but also of a military build-up focusing on the Indian Ocean.

  15. A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4

    Siming Tang

    2017-01-01

    Full Text Available The Middle East respiratory syndrome (MERS coronavirus, a newly identified pathogen, causes severe pneumonia in humans. MERS is caused by a coronavirus known as MERS-CoV, which attacks the respiratory system. The recently defined receptor for MERS-CoV, dipeptidyl peptidase 4 (DPP4, is generally expressed in endothelial and epithelial cells and has been shown to be present on cultured human nonciliated bronchiolar epithelium cells. In this paper, a class of novel four-dimensional dynamic model describing the infection of MERS-CoV is given, and then global stability of the equilibria of the model is discussed. Our results show that the spread of MERS-CoV can also be controlled by decreasing the expression rate of DPP4.

  16. Ensuring a successful family business management succession

    Desbois, Joris

    2016-01-01

    Succession is the biggest long-term challenge that most family businesses face. Indeed, leaders ‘disposition to plan for their succession is frequently the key factor defining whether their family business subsists or stops. The research seeks to find out how to manage successfully the business management succession over main principles. This work project aims at researching the key points relevant to almost all family firms, to have a viable succession transition and positioni...

  17. MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity.

    Chu, Daniel K W; Hui, Kenrie P Y; Perera, Ranawaka A P M; Miguel, Eve; Niemeyer, Daniela; Zhao, Jincun; Channappanavar, Rudragouda; Dudas, Gytis; Oladipo, Jamiu O; Traoré, Amadou; Fassi-Fihri, Ouafaa; Ali, Abraham; Demissié, Getnet F; Muth, Doreen; Chan, Michael C W; Nicholls, John M; Meyerholz, David K; Kuranga, Sulyman A; Mamo, Gezahegne; Zhou, Ziqi; So, Ray T Y; Hemida, Maged G; Webby, Richard J; Roger, Francois; Rambaut, Andrew; Poon, Leo L M; Perlman, Stanley; Drosten, Christian; Chevalier, Veronique; Peiris, Malik

    2018-03-20

    Middle East respiratory syndrome coronavirus (MERS-CoV) causes a zoonotic respiratory disease of global public health concern, and dromedary camels are the only proven source of zoonotic infection. Although MERS-CoV infection is ubiquitous in dromedaries across Africa as well as in the Arabian Peninsula, zoonotic disease appears confined to the Arabian Peninsula. MERS-CoVs from Africa have hitherto been poorly studied. We genetically and phenotypically characterized MERS-CoV from dromedaries sampled in Morocco, Burkina Faso, Nigeria, and Ethiopia. Viruses from Africa (clade C) are phylogenetically distinct from contemporary viruses from the Arabian Peninsula (clades A and B) but remain antigenically similar in microneutralization tests. Viruses from West (Nigeria, Burkina Faso) and North (Morocco) Africa form a subclade, C1, that shares clade-defining genetic signatures including deletions in the accessory gene ORF4b Compared with human and camel MERS-CoV from Saudi Arabia, virus isolates from Burkina Faso (BF785) and Nigeria (Nig1657) had lower virus replication competence in Calu-3 cells and in ex vivo cultures of human bronchus and lung. BF785 replicated to lower titer in lungs of human DPP4-transduced mice. A reverse genetics-derived recombinant MERS-CoV (EMC) lacking ORF4b elicited higher type I and III IFN responses than the isogenic EMC virus in Calu-3 cells. However, ORF4b deletions may not be the major determinant of the reduced replication competence of BF785 and Nig1657. Genetic and phenotypic differences in West African viruses may be relevant to zoonotic potential. There is an urgent need for studies of MERS-CoV at the animal-human interface. Copyright © 2018 the Author(s). Published by PNAS.

  18. Chromatin accessibility prediction via convolutional long short-term memory networks with k-mer embedding.

    Min, Xu; Zeng, Wanwen; Chen, Ning; Chen, Ting; Jiang, Rui

    2017-07-15

    Experimental techniques for measuring chromatin accessibility are expensive and time consuming, appealing for the development of computational approaches to predict open chromatin regions from DNA sequences. Along this direction, existing methods fall into two classes: one based on handcrafted k -mer features and the other based on convolutional neural networks. Although both categories have shown good performance in specific applications thus far, there still lacks a comprehensive framework to integrate useful k -mer co-occurrence information with recent advances in deep learning. We fill this gap by addressing the problem of chromatin accessibility prediction with a convolutional Long Short-Term Memory (LSTM) network with k -mer embedding. We first split DNA sequences into k -mers and pre-train k -mer embedding vectors based on the co-occurrence matrix of k -mers by using an unsupervised representation learning approach. We then construct a supervised deep learning architecture comprised of an embedding layer, three convolutional layers and a Bidirectional LSTM (BLSTM) layer for feature learning and classification. We demonstrate that our method gains high-quality fixed-length features from variable-length sequences and consistently outperforms baseline methods. We show that k -mer embedding can effectively enhance model performance by exploring different embedding strategies. We also prove the efficacy of both the convolution and the BLSTM layers by comparing two variations of the network architecture. We confirm the robustness of our model to hyper-parameters by performing sensitivity analysis. We hope our method can eventually reinforce our understanding of employing deep learning in genomic studies and shed light on research regarding mechanisms of chromatin accessibility. The source code can be downloaded from https://github.com/minxueric/ismb2017_lstm . tingchen@tsinghua.edu.cn or ruijiang@tsinghua.edu.cn. Supplementary materials are available at

  19. Biomolecular Mechanisms of Mercury Transfers and Transformations by Proteins of the Mer Operon

    Miller, S. M.; Hong, B.; Nauss, R.; Momany, C.; Summers, A. O.; Feng, X.; Harwood, I.; Stroud, R.

    2008-12-01

    Aerobic bacteria exhibiting resistance to the toxic effects of Hg(II) and organomercurials [RHg(I), e.g. MeHg(I)] and are widely found in both pristine and mercury contaminated environments. Resistance, afforded by a plasmid- or transposon-associated mer operon, involves an unusual pathway where Hg(II) and organomercurials [RHg(I)] undergo facilitated entry into the bacterial cytoplasm via an integral membrane transport protein (MerT) and are then "detoxified" by the concerted effort of two enzymes, organomercurial lyase (MerB), which catalyzes dealkylation (i.e., demethylation) of RHg(I) to Hg(II) and a hydrocarbon, and mercuric ion reductase (MerA), which catalyzes reduction of Hg(II) to Hg(0) as the ultimate detoxification for the organism. With a widespread distribution, these bacterial transformations play a significant role in the fate of mercury in the environment. Our focus is on elucidation of the molecular mechanisms for the transport and catalytic transformations of RHg(I) and Hg(II) by these proteins and the factors that influence the overall efficiency of the process. Current efforts are focused primarily on elucidating details of RHg(I) binding and dealkylation by MerB as well as the mechanism for transfer of the Hg(II) product to MerA. Key findings include the demonstration of a non-cysteine residue as essential for the catalytic activity and demonstration that direct transfer of Hg(II) to MerA proceeds more rapidly and more completely than transfer to small MW thiols such as cysteines or glutathione. Reuslts of these studies as well as an overview of our current understanding of the whole system will be presented.

  20. Worry experienced during the 2015 Middle East Respiratory Syndrome (MERS pandemic in Korea.

    Jun-Soo Ro

    Full Text Available Korea failed in its risk communication during the early stage of the Middle East Respiratory Syndrome (MERS outbreak; consequently, it faced difficulties in managing MERS, while disease-related worry increased. Disease-related worry can help disease prevention and management, but can also have a detrimental effect. This study measured the overall level of disease-related worry during the MERS outbreak period in Korea and the influencing factors and levels of disease-related worry during key outbreak periods.The cross-sectional survey included 1,000 adults who resided in Korea. An ordinal logistic regression was performed for the overall level of MERS-related worry, and influencing factors of worry were analyzed. A reliability test was performed on the levels of MERS-related worry during key outbreak periods.The overall level of MERS-related worry was 2.44. Multivariate analysis revealed that women and respondents w very poor subjective health status had higher levels of worry. Respondents with very high stress in daily life had higher levels of worry than those who reported having little stress. The reliability test results on MERS-related worry scores during key outbreak periods showed consistent scores during each period.Level of worry increased in cases having higher perceived susceptibility and greater trust in informal information, while initial stage of outbreak was closely associated with that at later stages. These findings suggest the importance of managing the level of worry by providing timely and accurate disease-related information during the initial stage of disease outbreak.

  1. Isolation and Cloning of mercuric reductase gene (merA from mercury-resistant bacteria

    Parisa Khoshniyat

    2018-03-01

    Full Text Available Introduction: Some of the bacteria having merA gene coding mineral mercury reducing enzyme, has genetic potential of Hg removing via reduction of mineral mercury and transformation of that to gas form and finally bioremediation of polluted area. The aim of this study is the isolation of merA gene from resistance bacteria and cloning of that into suitable expression vector and then the environmental bioremediation by the transformation of bacteria with this vector. Materials and methods: A number of bacteria were collected in contaminated areas with mercury in order to isolate merA genes. Polymerase chain reaction had done on the four bacterial genomes including Klebsiella pneumoniae, Pseudomonas aeruginosa, Serratia marcescens and Escherichia coli using the specific primers in order to detect merA gene. For cloning, the primers containing restriction enzyme sites are used, merA gene was isolated and amplified. The amplified fragments were cloned in the expression vector pET21a+ and via heat shock method were transformed into E. coli TOP10 competent cell. For clustering of genes, Mega software version 4 was used and bioanformatic studies were achieved for predicted enzyme. Results: merA gene with 1686 bp in length was isolated from K pneumoniae and E. coli. Recombinant vectors in transgenic bacteria were confirmed by various methods and finally were confirmed by sequencing. The result of clustering these genes with existence genes in NCBI showed high similarity. Discussion and conclusion: The existence of merA gene in bacteria that adapted to Hg pollution area is because of resistance, so with cloning this gene into suitable expression vector and transformation of susceptible bacteria with this vector ability of resistance to Hg in bacteria for bioremediation could be given.

  2. Full-Scaled Advanced Systems Testbed: Ensuring Success of Adaptive Control Research Through Project Lifecycle Risk Mitigation

    Pavlock, Kate M.

    2011-01-01

    The National Aeronautics and Space Administration's Dryden Flight Research Center completed flight testing of adaptive controls research on the Full-Scale Advance Systems Testbed (FAST) in January of 2011. The research addressed technical challenges involved with reducing risk in an increasingly complex and dynamic national airspace. Specific challenges lie with the development of validated, multidisciplinary, integrated aircraft control design tools and techniques to enable safe flight in the presence of adverse conditions such as structural damage, control surface failures, or aerodynamic upsets. The testbed is an F-18 aircraft serving as a full-scale vehicle to test and validate adaptive flight control research and lends a significant confidence to the development, maturation, and acceptance process of incorporating adaptive control laws into follow-on research and the operational environment. The experimental systems integrated into FAST were designed to allow for flexible yet safe flight test evaluation and validation of modern adaptive control technologies and revolve around two major hardware upgrades: the modification of Production Support Flight Control Computers (PSFCC) and integration of two, fourth-generation Airborne Research Test Systems (ARTS). Post-hardware integration verification and validation provided the foundation for safe flight test of Nonlinear Dynamic Inversion and Model Reference Aircraft Control adaptive control law experiments. To ensure success of flight in terms of cost, schedule, and test results, emphasis on risk management was incorporated into early stages of design and flight test planning and continued through the execution of each flight test mission. Specific consideration was made to incorporate safety features within the hardware and software to alleviate user demands as well as into test processes and training to reduce human factor impacts to safe and successful flight test. This paper describes the research configuration

  3. Mild encephalitis/encephalopathy with reversible splenial lesion (MERS) in adults-a case report and literature review.

    Yuan, Junliang; Yang, Shuna; Wang, Shuangkun; Qin, Wei; Yang, Lei; Hu, Wenli

    2017-05-25

    Mild encephalitis/encephalopathy with reversible splenial lesion (MERS) is a rare clinico-radiological entity characterized by the magnetic resonance imaging (MRI) finding of a reversible lesion in the corpus callosum, sometimes involved the symmetrical white matters. Many cases of child-onset MERS with various causes have been reported. However, adult-onset MERS is relatively rare. The clinical characteristics and pathophysiologiccal mechanisms of adult-onset MERS are not well understood. We reviewed the literature on adult-onset MERS in order to describe the characteristics of MERS in adults and to provide experiences for clinician. We reported a case of adult-onset MERS with acute urinary retension and performed literature search from PubMed and web of science databases to identify other adult-onset MERS reports from Januarary 2004 to March 2016. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed on selection process. And then we summarized the clinico-radiological features of adult-onset MERS. Twenty-nine adult-onset MERS cases were reviewed from available literature including the case we have. 86.2% of the cases (25/29) were reported in Asia, especially in Japan. Ages varied between 18 and 59 years old with a 12:17 female-to-male ratio. The major cause was infection by virus or bacteria. Fever and headache were the most common clinical manifestation, and acute urinary retention was observed in 6 patients. All patients recovered completely within a month. Adult-onset MERS is an entity with a broad clinico-radiological spectrum because of the various diseases and conditions. There are similar characteristics between MERS in adults and children, also some differences.

  4. The feeling of family success and the professional burnout syndrome among penitentiary staff (a draft of a research project

    Agnieszka Barczykowska

    2011-12-01

    Full Text Available Mutual relations between family and professional life have been for many years one of the most important fields of research in economics, sociology and, more and more often, pedagogy, which focuses on searching for factors protecting from the development of burnout syndrome and aims at increasing the effectiveness of pedagogic efforts. Due to the above, this article, being a draft of a research project, is dedicated to the facilitating effect of family life on professional life of the penitentiary staff. The authors take a stance that the feeling of satisfaction from family life can not only significantly neutralize the feeling of failure but, primarily, contribute to the search for more and more innovative forms of work.

  5. Increasing student success in STEM through geosciences based GIS curriculum, interdisciplinary project based learning, and specialized STEM student services

    Cheung, W.

    2012-12-01

    Under the auspices of the National Science Foundation's Advanced Technological Education Grant and the Department of Education's Title V/HSI Grant, Palomar College students from a variety of disciplines have not only been exposed to the high growth field of geospatial technologies, but have also been exposed to the geosciences and regional environmental issues in their GIS courses. By integrating introductory Physical Geography topics such as liquefaction, subsidence, ozone depletion, plate tectonics, and coastal processes in the introductory GIS curriculum, GIS students from fields ranging from Archaeology to Zoology were exposed to basic geosciences theories in a series of hands-on interactive exercises, while gaining competency in geospatial technologies. Additionally, as students undertake interdisciplinary service learning projects under the supervision of experts in the private, governmental, and nonprofit sectors, students were introduced to the STEM workplace, forged invaluable professional connections, applied their classroom knowledge to advance research (e.g. analyzing migration patterns of cephalopod), and analyzed regional environmental issues (e.g. distribution of invasive plants in state natural preserves). In order to further the retention and completion of students in GIS, Earth Science, and other STEM courses, a STEM Student Learning Center was constructed, whereby students can receive services such as supplemental instruction, walk-in tutoring, STEM counseling and transfer advising, as well as faculty and peer mentoring.

  6. Project (inverted exclamation mark)EXITO!: success through diversity and universality for outcomes improvement among Hispanic home care patients.

    Woerner, Louise; Espinosa, Javier; Bourne, Susan; O'Toole, Marie; Ingersoll, Gail L

    2009-01-01

    The National Health Disparities Report notes that Hispanics have poorer quality of care in 23 of 38 core measures. The result of this disparity is great personal and health system costs, which could be reduced. Prior studies have focused on access and language. We studied outcomes improvement. The purpose of this project was to develop a replicable theory-based outcomes improvement model for delivery of nursing care to Hispanic patients. The Leininger Sunrise Enabler approach was used to design a program specific to the cultural needs of a home care population. Outcome and Assessment Information Set (OASIS) data from 125 unduplicated home care patients were tracked. Nursing care delivery was analyzed using ethnographic research techniques. Delivery of nursing care using a culturally congruent approach reduced acute hospitalization and emergent care visits. Medication management and customer and nursing satisfaction also improved. National standards for culturally and linguistically appropriate services in health care help reduce healthcare disparities, but improving Hispanic outcomes requires moving beyond symptoms and symptom management to transcultural care. The estimated savings to the health care system are significant.

  7. Projectables

    Rasmussen, Troels A.; Merritt, Timothy R.

    2017-01-01

    CNC cutting machines have become essential tools for designers and architects enabling rapid prototyping, model-building and production of high quality components. Designers often cut from new materials, discarding the irregularly shaped remains. We introduce ProjecTables, a visual augmented...... reality system for interactive packing of model parts onto sheet materials. ProjecTables enables designers to (re)use scrap materials for CNC cutting that would have been previously thrown away, at the same time supporting aesthetic choices related to wood grain, avoiding surface blemishes, and other...... relevant material properties. We conducted evaluations of ProjecTables with design students from Aarhus School of Architecture, demonstrating that participants could quickly and easily place and orient model parts reducing material waste. Contextual interviews and ideation sessions led to a deeper...

  8. Comparing fixed sampling with minimizer sampling when using k-mer indexes to find maximal exact matches.

    Almutairy, Meznah; Torng, Eric

    2018-01-01

    Bioinformatics applications and pipelines increasingly use k-mer indexes to search for similar sequences. The major problem with k-mer indexes is that they require lots of memory. Sampling is often used to reduce index size and query time. Most applications use one of two major types of sampling: fixed sampling and minimizer sampling. It is well known that fixed sampling will produce a smaller index, typically by roughly a factor of two, whereas it is generally assumed that minimizer sampling will produce faster query times since query k-mers can also be sampled. However, no direct comparison of fixed and minimizer sampling has been performed to verify these assumptions. We systematically compare fixed and minimizer sampling using the human genome as our database. We use the resulting k-mer indexes for fixed sampling and minimizer sampling to find all maximal exact matches between our database, the human genome, and three separate query sets, the mouse genome, the chimp genome, and an NGS data set. We reach the following conclusions. First, using larger k-mers reduces query time for both fixed sampling and minimizer sampling at a cost of requiring more space. If we use the same k-mer size for both methods, fixed sampling requires typically half as much space whereas minimizer sampling processes queries only slightly faster. If we are allowed to use any k-mer size for each method, then we can choose a k-mer size such that fixed sampling both uses less space and processes queries faster than minimizer sampling. The reason is that although minimizer sampling is able to sample query k-mers, the number of shared k-mer occurrences that must be processed is much larger for minimizer sampling than fixed sampling. In conclusion, we argue that for any application where each shared k-mer occurrence must be processed, fixed sampling is the right sampling method.

  9. Comparing fixed sampling with minimizer sampling when using k-mer indexes to find maximal exact matches.

    Meznah Almutairy

    Full Text Available Bioinformatics applications and pipelines increasingly use k-mer indexes to search for similar sequences. The major problem with k-mer indexes is that they require lots of memory. Sampling is often used to reduce index size and query time. Most applications use one of two major types of sampling: fixed sampling and minimizer sampling. It is well known that fixed sampling will produce a smaller index, typically by roughly a factor of two, whereas it is generally assumed that minimizer sampling will produce faster query times since query k-mers can also be sampled. However, no direct comparison of fixed and minimizer sampling has been performed to verify these assumptions. We systematically compare fixed and minimizer sampling using the human genome as our database. We use the resulting k-mer indexes for fixed sampling and minimizer sampling to find all maximal exact matches between our database, the human genome, and three separate query sets, the mouse genome, the chimp genome, and an NGS data set. We reach the following conclusions. First, using larger k-mers reduces query time for both fixed sampling and minimizer sampling at a cost of requiring more space. If we use the same k-mer size for both methods, fixed sampling requires typically half as much space whereas minimizer sampling processes queries only slightly faster. If we are allowed to use any k-mer size for each method, then we can choose a k-mer size such that fixed sampling both uses less space and processes queries faster than minimizer sampling. The reason is that although minimizer sampling is able to sample query k-mers, the number of shared k-mer occurrences that must be processed is much larger for minimizer sampling than fixed sampling. In conclusion, we argue that for any application where each shared k-mer occurrence must be processed, fixed sampling is the right sampling method.

  10. Comparing fixed sampling with minimizer sampling when using k-mer indexes to find maximal exact matches

    Torng, Eric

    2018-01-01

    Bioinformatics applications and pipelines increasingly use k-mer indexes to search for similar sequences. The major problem with k-mer indexes is that they require lots of memory. Sampling is often used to reduce index size and query time. Most applications use one of two major types of sampling: fixed sampling and minimizer sampling. It is well known that fixed sampling will produce a smaller index, typically by roughly a factor of two, whereas it is generally assumed that minimizer sampling will produce faster query times since query k-mers can also be sampled. However, no direct comparison of fixed and minimizer sampling has been performed to verify these assumptions. We systematically compare fixed and minimizer sampling using the human genome as our database. We use the resulting k-mer indexes for fixed sampling and minimizer sampling to find all maximal exact matches between our database, the human genome, and three separate query sets, the mouse genome, the chimp genome, and an NGS data set. We reach the following conclusions. First, using larger k-mers reduces query time for both fixed sampling and minimizer sampling at a cost of requiring more space. If we use the same k-mer size for both methods, fixed sampling requires typically half as much space whereas minimizer sampling processes queries only slightly faster. If we are allowed to use any k-mer size for each method, then we can choose a k-mer size such that fixed sampling both uses less space and processes queries faster than minimizer sampling. The reason is that although minimizer sampling is able to sample query k-mers, the number of shared k-mer occurrences that must be processed is much larger for minimizer sampling than fixed sampling. In conclusion, we argue that for any application where each shared k-mer occurrence must be processed, fixed sampling is the right sampling method. PMID:29389989

  11. Preliminary analysis of the MER magnetic properties experiment using a computational fluid dynamics model

    Kinch, K.M.; Merrison, J.P.; Gunnlaugsson, H.P.

    2006-01-01

    Motivated by questions raised by the magnetic properties experiments on the NASA Mars Pathfinder and Mars Exploration Rover (MER) missions, we have studied in detail the capture of airborne magnetic dust by permanent magnets using a computational fluid dynamics (CFD) model supported by laboratory...... simulations. The magnets studied are identical to the capture magnet and filter magnet on MER, though results are more generally applicable. The dust capture process is found to be dependent upon wind speed, dust magnetization, dust grain size and dust grain mass density. Here we develop an understanding...... of how these parameters affect dust capture rates and patterns on the magnets and set bounds for these parameters based on MER data and results from the numerical model. This results in a consistent picture of the dust as containing varying amounts of at least two separate components with different...

  12. Intégration régionale et politique des outre-mers

    Didier Benjamin

    1999-06-01

    Full Text Available Grâce à ses outre-mers, qui lui apportent 96% de sa zone économique exclusive, la France dispose du troisième domaine maritime du monde et assure une présence sur tous les océans. Cependant, les outre-mers ne jouent plus qu'un rôle mineur dans la politique des océans. Ce paradoxe s'explique en partie par les difficultés qu'ils rencontrent à s'insérer dans les échanges internationaux et à s'intégrer aux organisations régionales. Les différences de niveaux de développement socioéconomique avec les pays voisins contribuent à isoler les outre-mers dans leur environnement immédiat.

  13. Application of a mer-lux biosensor for estimating bioavailable mercury in soil

    Rasmussen, Lasse Dam; Sørensen, S. J.; Turner, R. R.

    2000-01-01

    A previously described bioassay using a mer-lux gene fusion for detection of bioavailable mercury was applied for the estimation of the bioavailable fraction of mercury in soil. The bioavailable fraction is defined here as being part of the water leachable fraction. Due to masking of light emission...... responses. The utility of the mer-lux biosensor assay was tested by relating measurements of bioavailable and total mercury to the response of the soil microbial community to mercury exposure. Two different soil types (an agricultural and a beech forest soil) were spiked with 2.5 µg Hg(II) g-1 in microcosms...... in resistance or diversity. This study showed that the bioassay using the mer-lux biosensor is a useful and sensitive tool for estimation of bioavailable mercury in soil....

  14. Identifying Monoclonal Antibodies that Potently Inhibit MERS-CoV | Center for Cancer Research

    The Middle East respiratory syndrome coronavirus (MERS-CoV), first isolated in September 2012, infects cells lining the human airway, causing severe flu-like symptoms that, in some cases, lead to death. As of July 2, 2014, 824 confirmed cases of MERS-CoV infection, including at least 286 related deaths, have been reported to the World Health Organization. While there are currently no effective therapies against the virus, monoclonal antibodies (MAbs) may be a promising candidate. Having previously developed MAbs against other viruses, including the related severe acute respiratory syndrome coronavirus or SARS-CoV, Dimiter Dimitrov, Ph.D., of CCR’s Laboratory of Experimental Immunology (LEI), and his colleagues decided to pan a library of antigen binding fragments (Fab) for activity against MERS-CoV.

  15. KGCAK: a K-mer based database for genome-wide phylogeny and complexity evaluation.

    Wang, Dapeng; Xu, Jiayue; Yu, Jun

    2015-09-16

    The K-mer approach, treating genomic sequences as simple characters and counting the relative abundance of each string upon a fixed K, has been extensively applied to phylogeny inference for genome assembly, annotation, and comparison. To meet increasing demands for comparing large genome sequences and to promote the use of the K-mer approach, we develop a versatile database, KGCAK ( http://kgcak.big.ac.cn/KGCAK/ ), containing ~8,000 genomes that include genome sequences of diverse life forms (viruses, prokaryotes, protists, animals, and plants) and cellular organelles of eukaryotic lineages. It builds phylogeny based on genomic elements in an alignment-free fashion and provides in-depth data processing enabling users to compare the complexity of genome sequences based on K-mer distribution. We hope that KGCAK becomes a powerful tool for exploring relationship within and among groups of species in a tree of life based on genomic data.

  16. 3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012

    Johnson, Reed F.; Bagci, Ulas; Keith, Lauren; Tang, Xianchun; Mollura, Daniel J.; Zeitlin, Larry; Qin, Jing; Huzella, Louis; Bartos, Christopher J.; Bohorova, Natasha; Bohorov, Ognian; Goodman, Charles; Kim, Do H.; Paulty, Michael H.; Velasco, Jesus; Whaley, Kevin J.; Johnson, Joshua C.; Pettitt, James; Ork, Britini L.; Solomon, Jeffrey

    2016-01-01

    Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was identified in 2012 as the causative agent of a severe, lethal respiratory disease occurring across several countries in the Middle East. To date there have been over 1600 laboratory confirmed cases of MERS-CoV in 26 countries with a case fatality rate of 36%. Given the endemic region, it is possible that MERS-CoV could spread during the annual Hajj pilgrimage, necessitating countermeasure development. In this report, we describe the clinical and radiographic changes of rhesus monkeys following infection with 5×10"6 PFU MERS-CoV Jordan-n3/2012. Two groups of NHPs were treated with either a human anti-MERS monoclonal antibody 3B11-N or E410-N, an anti-HIV antibody. MERS-CoV Jordan-n3/2012 infection resulted in quantifiable changes by computed tomography, but limited other clinical signs of disease. 3B11-N treated subjects developed significantly reduced lung pathology when compared to infected, untreated subjects, indicating that this antibody may be a suitable MERS-CoV treatment. - Highlights: • MERS-CoV Jordan-n3/2012 challenge of rhesus monkeys results in a mild disease. • CT can be used to monitor disease progression to aid models of human disease. • Treatment with the human monoclonal antibody 3B11-N resulted in decreased disease.

  17. Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease

    Johnson, Reed F., E-mail: johnsonreed@mail.nih.gov [Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD (United States); Via, Laura E. [Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (United States); Kumar, Mia R.; Cornish, Joseph P. [Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD (United States); Yellayi, Srikanth; Huzella, Louis; Postnikova, Elena; Oberlander, Nicholas; Bartos, Christopher; Ork, Britini L.; Mazur, Steven; Allan, Cindy; Holbrook, Michael R. [Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD (United States); Solomon, Jeffrey [Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD (United States); Johnson, Joshua C. [Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD (United States); Pickel, James [Transgenic Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, MD (United States); Hensley, Lisa E. [Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD (United States); Jahrling, Peter B. [Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD (United States); Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD (United States)

    2015-11-15

    Middle East Respiratory Syndrome Coronavirus (MERS-CoV) continues to be a threat to human health in the Middle East. Development of countermeasures is ongoing; however, an animal model that faithfully recapitulates human disease has yet to be defined. A recent study indicated that inoculation of common marmosets resulted in inconsistent lethality. Based on these data we sought to compare two isolates of MERS-CoV. We followed disease progression in common marmosets after intratracheal exposure with: MERS-CoV-EMC/2012, MERS-CoV-Jordan-n3/2012, media, or inactivated virus. Our data suggest that common marmosets developed a mild to moderate non-lethal respiratory disease, which was quantifiable by computed tomography (CT), with limited other clinical signs. Based on CT data, clinical data, and virological data, MERS-CoV inoculation of common marmosets results in mild to moderate clinical signs of disease that are likely due to manipulations of the marmoset rather than as a result of robust viral replication. - Highlights: • Common marmosets infected with MERS-EMC and MERS-JOR did not develop lethal disease. • Infected subjects developed transient signs of clinical disease. • CT indicated few differences between the infected and control groups. • Marmosets do not faithfully replicate human MERS pathogenesis.

  18. Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease

    Johnson, Reed F.; Via, Laura E.; Kumar, Mia R.; Cornish, Joseph P.; Yellayi, Srikanth; Huzella, Louis; Postnikova, Elena; Oberlander, Nicholas; Bartos, Christopher; Ork, Britini L.; Mazur, Steven; Allan, Cindy; Holbrook, Michael R.; Solomon, Jeffrey; Johnson, Joshua C.; Pickel, James; Hensley, Lisa E.; Jahrling, Peter B.

    2015-01-01

    Middle East Respiratory Syndrome Coronavirus (MERS-CoV) continues to be a threat to human health in the Middle East. Development of countermeasures is ongoing; however, an animal model that faithfully recapitulates human disease has yet to be defined. A recent study indicated that inoculation of common marmosets resulted in inconsistent lethality. Based on these data we sought to compare two isolates of MERS-CoV. We followed disease progression in common marmosets after intratracheal exposure with: MERS-CoV-EMC/2012, MERS-CoV-Jordan-n3/2012, media, or inactivated virus. Our data suggest that common marmosets developed a mild to moderate non-lethal respiratory disease, which was quantifiable by computed tomography (CT), with limited other clinical signs. Based on CT data, clinical data, and virological data, MERS-CoV inoculation of common marmosets results in mild to moderate clinical signs of disease that are likely due to manipulations of the marmoset rather than as a result of robust viral replication. - Highlights: • Common marmosets infected with MERS-EMC and MERS-JOR did not develop lethal disease. • Infected subjects developed transient signs of clinical disease. • CT indicated few differences between the infected and control groups. • Marmosets do not faithfully replicate human MERS pathogenesis.

  19. 3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012

    Johnson, Reed F., E-mail: johnsonreed@mail.nih.gov [Emerging Viral Pathogens Section National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702 (United States); Bagci, Ulas [Center for Infectious Disease Imaging, National Institutes of Health Clinical Center, Bethesda MD 20892 (United States); Center for Research in Computer Vision (CRCV), Department of Electrics Electronics and Computer Science, University of Central Florida, Orlando, FL 32816, USA. (United States); Keith, Lauren [Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702 (United States); Tang, Xianchun [Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215 (United States); Mollura, Daniel J. [Center for Infectious Disease Imaging, National Institutes of Health Clinical Center, Bethesda MD 20892 (United States); Zeitlin, Larry [Mapp Biopharmaceutical, Inc., San Diego CA 92121 (United States); Qin, Jing [Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 (United States); Huzella, Louis; Bartos, Christopher J. [Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702 (United States); Bohorova, Natasha; Bohorov, Ognian; Goodman, Charles; Kim, Do H.; Paulty, Michael H.; Velasco, Jesus; Whaley, Kevin J. [Mapp Biopharmaceutical, Inc., San Diego CA 92121 (United States); Johnson, Joshua C.; Pettitt, James; Ork, Britini L. [Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702 (United States); Solomon, Jeffrey [Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research,Frederick, MD 21702-USA. (United States); and others

    2016-03-15

    Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was identified in 2012 as the causative agent of a severe, lethal respiratory disease occurring across several countries in the Middle East. To date there have been over 1600 laboratory confirmed cases of MERS-CoV in 26 countries with a case fatality rate of 36%. Given the endemic region, it is possible that MERS-CoV could spread during the annual Hajj pilgrimage, necessitating countermeasure development. In this report, we describe the clinical and radiographic changes of rhesus monkeys following infection with 5×10{sup 6} PFU MERS-CoV Jordan-n3/2012. Two groups of NHPs were treated with either a human anti-MERS monoclonal antibody 3B11-N or E410-N, an anti-HIV antibody. MERS-CoV Jordan-n3/2012 infection resulted in quantifiable changes by computed tomography, but limited other clinical signs of disease. 3B11-N treated subjects developed significantly reduced lung pathology when compared to infected, untreated subjects, indicating that this antibody may be a suitable MERS-CoV treatment. - Highlights: • MERS-CoV Jordan-n3/2012 challenge of rhesus monkeys results in a mild disease. • CT can be used to monitor disease progression to aid models of human disease. • Treatment with the human monoclonal antibody 3B11-N resulted in decreased disease.

  20. Healthcare Workers Emotions, Perceived Stressors and Coping Strategies During a MERS-CoV Outbreak.

    Khalid, Imran; Khalid, Tabindeh J; Qabajah, Mohammed R; Barnard, Aletta G; Qushmaq, Ismael A

    2016-03-01

    Healthcare workers (HCWs) are at high risk of contracting Middle East respiratory syndrome coronavirus (MERS-CoV) during an epidemic. We explored the emotions, perceived stressors, and coping strategies of healthcare workers who worked during a MERS-CoV outbreak in our hospital. A cross-sectional descriptive survey design. A tertiary care hospital. HCWs (150) who worked in high risk areas during the April-May 2014 MERS-CoV outbreak that occurred in Jeddah, Saudi Arabia. We developed and administered a "MERS-CoV staff questionnaire" to study participants. The questionnaire consisted of 5 sections with 72 questions. The sections evaluated hospital staffs emotions, perceived stressors, factors that reduced their stress, coping strategies, and motivators to work during future outbreaks. Responses were scored on a scale from 0-3. The varying levels of stress or effectiveness of measures were reported as mean and standard deviation, as appropriate. Completed questionnaires were returned by 117 (78%) of the participants. The results had many unique elements. HCWs ethical obligation to their profession pushed them to continue with their jobs. The main sentiments centered upon fear of personal safety and well-being of colleagues and family. Positive attitudes in the workplace, clinical improvement of infected colleagues, and stoppage of disease transmission among HCWs after adopting strict protective measures alleviated their fear and drove them through the epidemic. They appreciated recognition of their efforts by hospital management and expected similar acknowledgment, infection control guidance, and equipment would entice them to work during future epidemics. The MERS-CoV outbreak was a distressing time for our staff. Hospitals can enhance HCWs experiences during any future MERS-CoV outbreak by focusing on the above mentioned aspects. © 2016 Marshfield Clinic.

  1. Value, market preferences and trade of Beche-de-mer from Pacific Island sea cucumbers.

    Steven W Purcell

    Full Text Available Market preferences of natural resources contribute to shape their exploitation and production. Beche-de-mer, the product after gutting, cooking, salting and drying sea cucumbers, is exported worldwide to Asian dried seafood markets. A better understanding of the trade, value and market preferences of Pacific island beche-de-mer could identify critical postharvest processing techniques and management strategies for fisheries and aquaculture. Data were collected on export prices and trade of beche-de-mer from Kiribati, Fiji, Tonga and New Caledonia, and the selling prices, respective sizes and organoleptic properties of the products in stores in China. Export prices varied considerably within and among the four countries and low-value species were the most exported by volume. Most of the beche-de-mer from the four Pacific islands is exported to Hong Kong, where quality products are sold and others are distributed to mainland China. Prices of the beche-de-mer in Chinese stores varied up to ten-fold and were mostly influenced by species, body size and, to a lesser extent, physical damage to the products. Market prices across species (averaging US$15-385 kg-1 appear to have mostly increased six- to twelve-fold over the past decade. The data allude that fisheries for Holothuria scabra, H. lessoni, H. fuscogilva, H. whitmaei and Thelenota ananas should be most carefully managed because they were the highest-value species and under greatest demand. The relationships between size of beche-de-mer and sale price were species specific and highly varied. This study also highlights the need for better regulations and/or enforcement of minimum size limits in sea cucumber fisheries, which can help to maximise economic benefits of wild stocks.

  2. MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis

    Menachery, Vineet D.; Mitchell, Hugh D.; Cockrell, Adam S.; Gralinski, Lisa E.; Yount, Boyd L.; Graham, Rachel L.; McAnarney, Eileen T.; Douglas, Madeline G.; Scobey, Trevor; Beall, Anne; Dinnon, Kenneth; Kocher, Jacob F.; Hale, Andrew E.; Stratton, Kelly G.; Waters, Katrina M.; Baric, Ralph S.; Racaniello, Vincent R.

    2017-08-22

    ABSTRACT

    While dispensable for viral replication, coronavirus (CoV) accessory open reading frame (ORF) proteins often play critical roles during infection and pathogenesis. Utilizing a previously generated mutant, we demonstrate that the absence of all four Middle East respiratory syndrome CoV (MERS-CoV) accessory ORFs (deletion of ORF3, -4a, -4b, and -5 [dORF3-5]) has major implications for viral replication and pathogenesis. Importantly, attenuation of the dORF3-5 mutant is primarily driven by dysregulated host responses, including disrupted cell processes, augmented interferon (IFN) pathway activation, and robust inflammation.In vitroreplication attenuation also extends toin vivomodels, allowing use of dORF3-5 as a live attenuated vaccine platform. Finally, examination of ORF5 implicates a partial role in modulation of NF-κB-mediated inflammation. Together, the results demonstrate the importance of MERS-CoV accessory ORFs for pathogenesis and highlight them as potential targets for surveillance and therapeutic treatments moving forward.

    IMPORTANCEThe initial emergence and periodic outbreaks of MERS-CoV highlight a continuing threat posed by zoonotic pathogens to global public health. In these studies, mutant virus generation demonstrates the necessity of accessory ORFs in regard to MERS-CoV infection and pathogenesis. With this in mind, accessory ORF functions can be targeted for both therapeutic and vaccine treatments in response to MERS-CoV and related group 2C coronaviruses. In addition, disruption of accessory ORFs in parallel may offer a rapid response platform to attenuation of future emergent strains based on both SARS- and MERS-CoV accessory ORF mutants.

  3. mer-Triammine trifluorido vanadium(III), mer-[VF{sub 3}(NH{sub 3}){sub 3}]. Synthesis and crystal structure

    Woidy, Patrick [Technische Univ. Muenchen, Garching (Germany). Zentrale Technisch-Wissenschaftliche Betriebseinheit Radiochemie Muenchen RCM; Kraus, Florian [Marburg Univ. (Germany). Anorganische und Fluorchemie

    2015-07-01

    Vanadium trifluoride reacts with dry liquid ammonia under the formation of lilac plate-shaped crystals of mer-triammine trifluorido vanadium(III) (1), mer-[VF{sub 3}(NH{sub 3}){sub 3}]. Single-crystal X-ray analysis was carried out at low temperature to elucidate the structure. The compound crystallizes in the monoclinic space group P2{sup 1}/c with a = 5.7284(4), b = 9.2033(5), c = 10.5271(6) Aa, beta = 91.795(6)°, and V = 554.72(6) Aa{sup 3} at 123 K with Z = 4. The discrete [VF{sub 3}(NH{sub 3}){sub 3}] molecules are interconnected by hydrogen bonds.

  4. Differential expression of the MERS-coronavirus receptor in the upper respiratory tract of humans and dromedary camels

    Widagdo, W; Raj, V Stalin; Schipper, Debby; Kolijn, Kimberley; van Leenders, Geert J L H; Bosch, Berend J; Bensaid, Albert; Segalés, Joaquim; Baumgärtner, Wolfgang; Osterhaus, Albert D M E; Koopmans, Marion P; van den Brand, Judith M A; Haagmans, Bart L

    Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor - dipeptidyl peptidase 4 (DPP4) - is expressed in the upper respiratory tract epithelium of camels but not

  5. Healthcare worker exposure to Middle East respiratory syndrome coronavirus (MERS-CoV: Revision of screening strategies urgently needed

    Hala Amer

    2018-06-01

    Conclusions: The data obtained in this study support the widespread testing of all close contacts of MERS-CoV cases, regardless of the significance of the contact or presence or absence of symptoms. In addition, urgent careful review of guidance regarding the return of asymptomatic MERS-CoV-positive HCWs under investigation to active duty is needed.

  6. Serological evidence of MERS-CoV antibodies in dromedary camels (camelus dromedaries) in laikipia county, Kenya

    S.L. Deem (Sharon L.); E.M. Fèvre (Eric); M. Kinnaird (Margaret); A.S. Browne (A. Springer); D. Muloi (Dishon); G-J. Godeke (Gert-Jan); M.P.G. Koopmans D.V.M. (Marion); C.B.E.M. Reusken (Chantal)

    2015-01-01

    textabstractMiddle East respiratory syndrome coronavirus (MERS-CoV) is a recently identified virus causing severe viral respiratory illness in people. Little is known about the reservoir in the Horn of Africa. In Kenya, where no human MERS cases have been reported, our survey of 335 dromedary

  7. Public response to MERS-CoV in the Middle East: iPhone survey in six countries.

    Alqahtani, Amani S; Rashid, Harunor; Basyouni, Mada H; Alhawassi, Tariq M; BinDhim, Nasser F

    Gulf Cooperation Council (GCC) countries bear the heaviest brunt of MERS-CoV. This study aims to compare public awareness and practice around MERS-CoV across GCC countries. A cross-sectional survey was conducted using the Gulf Indicators (GI) smartphone app among people in the six GCC countries, namely Saudi Arabia, Kuwait, the United Arab Emirates, Qatar, Bahrain, and Oman. A total of 1812 participants recruited. All were aware of MERS-CoV, yet the perception and practice around MERS-CoV varied widely between countries. Over two thirds were either "not concerned" or "slightly concerned" about contracting MERS-CoV; believing that they were under Allah's (God's) protection (40%) was the most cited reason. While 79% were aware that the disease can transmit through droplet from infected person, only 12% stated that MERS-CoV transmits via camels; people in Saudi Arabia were better aware of the transmission. Nevertheless, only 22% of respondents believed that camels are the zoonotic reservoir of MERS-CoV. Those who were concerned about contracting MERS-CoV (aOR: 1.6, 95% CI: 1.2-2.1, pAuthors. Published by Elsevier Ltd.. All rights reserved.

  8. Mercuric ion reduction and resistance in transgenic Arabidopsis thaliana plants expressing a modified bacterial merA gene.

    Rugh, C L; Wilde, H D; Stack, N M; Thompson, D M; Summers, A O; Meagher, R B

    1996-01-01

    With global heavy metal contamination increasing, plants that can process heavy metals might provide efficient and ecologically sound approaches to sequestration and removal. Mercuric ion reductase, MerA, converts toxic Hg2+ to the less toxic, relatively inert metallic mercury (Hg0) The bacterial merA sequence is rich in CpG dinucleotides and has a highly skewed codon usage, both of which are particularly unfavorable to efficient expression in plants. We constructed a mutagenized merA sequence, merApe9, modifying the flanking region and 9% of the coding region and placing this sequence under control of plant regulatory elements. Transgenic Arabidopsis thaliana seeds expressing merApe9 germinated, and these seedlings grew, flowered, and set seed on medium containing HgCl2 concentrations of 25-100 microM (5-20 ppm), levels toxic to several controls. Transgenic merApe9 seedlings evolved considerable amounts of Hg0 relative to control plants. The rate of mercury evolution and the level of resistance were proportional to the steady-state mRNA level, confirming that resistance was due to expression of the MerApe9 enzyme. Plants and bacteria expressing merApe9 were also resistant to toxic levels of Au3+. These and other data suggest that there are potentially viable molecular genetic approaches to the phytoremediation of metal ion pollution. Images Fig. 2 Fig. 3 Fig. 4 PMID:8622910

  9. Kmerind: A Flexible Parallel Library for K-mer Indexing of Biological Sequences on Distributed Memory Systems.

    Pan, Tony; Flick, Patrick; Jain, Chirag; Liu, Yongchao; Aluru, Srinivas

    2017-10-09

    Counting and indexing fixed length substrings, or k-mers, in biological sequences is a key step in many bioinformatics tasks including genome alignment and mapping, genome assembly, and error correction. While advances in next generation sequencing technologies have dramatically reduced the cost and improved latency and throughput, few bioinformatics tools can efficiently process the datasets at the current generation rate of 1.8 terabases every 3 days. We present Kmerind, a high performance parallel k-mer indexing library for distributed memory environments. The Kmerind library provides a set of simple and consistent APIs with sequential semantics and parallel implementations that are designed to be flexible and extensible. Kmerind's k-mer counter performs similarly or better than the best existing k-mer counting tools even on shared memory systems. In a distributed memory environment, Kmerind counts k-mers in a 120 GB sequence read dataset in less than 13 seconds on 1024 Xeon CPU cores, and fully indexes their positions in approximately 17 seconds. Querying for 1% of the k-mers in these indices can be completed in 0.23 seconds and 28 seconds, respectively. Kmerind is the first k-mer indexing library for distributed memory environments, and the first extensible library for general k-mer indexing and counting. Kmerind is available at https://github.com/ParBLiSS/kmerind.

  10. Push-pull effect on the geometrical, optical and charge transfer properties of disubstituted derivatives of mer-tris(4-hydroxy-1,5-naphthyridinato aluminum (mer-AlND3

    Rao Joshi Laxmikanth

    2016-01-01

    Full Text Available To design innovative and novel optical materials with high mobility, two kinds of disubstituted derivatives for mer-tris(4-hydroxy-1,5-naphthyridinato aluminum (mer-AlND3 with push (EDG–pull (EWG substituents have been designed. The structures of mer-tris(8-EDG-2-EWG-4-hydroxy-1,5-naphthyridinato aluminum (type I and mer-tris(8-EWG-2-EDG-4-hydroxy-1,5-naphthyridinato aluminum (type II in the ground and first excited states have been optimized at the B3LYP/6-31G(D and CIS/6-31G(D level of theory, respectively. It can be seen from frontier molecular orbitals analysis, in all these complexes, the highest occupied molecular orbital (HOMO is localized on the pyridine-4-ol ring of A-ligand while lowest unoccupied molecular orbital (LUMO is on the pyridyl ring of B-ligand in ground state irrespective of electron donor/acceptor substitution present on the ligands similar to that of mer-tris(8-hydroxyquinoline aluminum (mer-Alq3 and parent mer-AlND3.The absorption and emission wavelengths have been evaluated at the TD-PBE0/6-31G(D level and it can be see that all the type I derivatives show blue shift while most of the type II derivatives show red shift compared to mer-AlND3. All the disubstituted complexes have showed hypsochromic shifts in both the absorption and emission spectra when compared with the calculated absorption and emission spectra respectively of mer-Alq3. It can be seen that the reorganization energies of some of the disubstituted derivatives are comparable with mer-Alq3 and these derivatives might be good candidates for emitting materials in OLED.

  11. Assessing Business Ideas for Starting-Up Successful Social Enterprises in Romania: an It-Supported, Micro-Regional Development Project

    Cezar Scarlat

    2011-12-01

    Full Text Available Purpose—This paper aims to develop a unique instrument to be used for both assessing business ideas and monitoring the respective social enterprises while taking off, eventually IT-supported.Design/methodology/approach—A sample of 25 cases was selected—in the framework of a regional development project in the Horezu micro-region, Romania (the IDEALIS Project implementation is scheduled for 2011-2012. Each case corresponds to a business idea for starting-up a social enterprise (either agricultural co-operative or co-operative enterprise in the region. The first phase of this project is to assess the viability of each business idea, and the second phase is to monitor the social start-ups as they are taking off. In both phases an original decision method is used, implanted on a methodology to assess the business idea’s probability to succeed. This paper was prepared after the completion of the first phase while an IT application was considered as a vehicle to use the proposed method for monitoring the newly created social enterprises.Findings/results—The proposed instrument (ABIDIS: Assessing Business Ideas by the DISTEH method was successfully used to associate a score to each business idea and, consequently, to rank the respective social enterprises accordingly: the higher the rank, the higher the chances to succeed. It is expected that social enterprises are considered for financial aid according to this ranking.Research limitations/implications—ABIDIS instrument is more useful when analyzed against a database of similar social enterprises and/or compared to its own historic data (which is monitoring actually. Amid successful method development and its use for assessing the chances of the social enterprises’ ideas to succeed, the practical use of the proposed methodology for monitoring the recently established social enterprises is still in progress. Furthermore, the rightness of the assessment is a matter of time—as it is going

  12. Comparison between SARS CoV and MERS CoV Using Apriori Algorithm, Decision Tree, SVM

    Jang Seongpil

    2016-01-01

    Full Text Available MERS (Middle East Respiratory Syndrome is a worldwide disease these days. The number of infected people is 1038(08/03/2015 in Saudi Arabia and 186(08/03/2015 in South Korea. MERS is all over the world including Europe and the fatality rate is 38.8%, East Asia and the Middle East. The MERS is also known as a cousin of SARS (Severe Acute Respiratory Syndrome because both diseases show similar symptoms such as high fever and difficulty in breathing. This is why we compared MERS with SARS. We used data of the spike glycoprotein from NCBI. As a way of analyzing the protein, apriori algorithm, decision tree, SVM were used, and particularly SVM was iterated by normal, polynomial, and sigmoid. The result came out that the MERS and the SARS are alike but also different in some way.

  13. Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia.

    Sabir, Jamal S M; Lam, Tommy T-Y; Ahmed, Mohamed M M; Li, Lifeng; Shen, Yongyi; Abo-Aba, Salah E M; Qureshi, Muhammd I; Abu-Zeid, Mohamed; Zhang, Yu; Khiyami, Mohammad A; Alharbi, Njud S; Hajrah, Nahid H; Sabir, Meshaal J; Mutwakil, Mohammed H Z; Kabli, Saleh A; Alsulaimany, Faten A S; Obaid, Abdullah Y; Zhou, Boping; Smith, David K; Holmes, Edward C; Zhu, Huachen; Guan, Yi

    2016-01-01

    Outbreaks of Middle East respiratory syndrome (MERS) raise questions about the prevalence and evolution of the MERS coronavirus (CoV) in its animal reservoir. Our surveillance in Saudi Arabia in 2014 and 2015 showed that viruses of the MERS-CoV species and a human CoV 229E-related lineage co-circulated at high prevalence, with frequent co-infections in the upper respiratory tract of dromedary camels. viruses of the betacoronavirus 1 species, we found that dromedary camels share three CoV species with humans. Several MERS-CoV lineages were present in camels, including a recombinant lineage that has been dominant since December 2014 and that subsequently led to the human outbreaks in 2015. Camels therefore serve as an important reservoir for the maintenance and diversification of the MERS-CoVs and are the source of human infections with this virus. Copyright © 2016, American Association for the Advancement of Science.

  14. Vis-NIR spectrometric determination of Brix and sucrose in sugar production samples using kernel partial least squares with interval selection based on the successive projections algorithm.

    de Almeida, Valber Elias; de Araújo Gomes, Adriano; de Sousa Fernandes, David Douglas; Goicoechea, Héctor Casimiro; Galvão, Roberto Kawakami Harrop; Araújo, Mario Cesar Ugulino

    2018-05-01

    This paper proposes a new variable selection method for nonlinear multivariate calibration, combining the Successive Projections Algorithm for interval selection (iSPA) with the Kernel Partial Least Squares (Kernel-PLS) modelling technique. The proposed iSPA-Kernel-PLS algorithm is employed in a case study involving a Vis-NIR spectrometric dataset with complex nonlinear features. The analytical problem consists of determining Brix and sucrose content in samples from a sugar production system, on the basis of transflectance spectra. As compared to full-spectrum Kernel-PLS, the iSPA-Kernel-PLS models involve a smaller number of variables and display statistically significant superiority in terms of accuracy and/or bias in the predictions. Published by Elsevier B.V.

  15. Human Infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013

    Memish, Ziad A.; Cotten, Matthew; Meyer, Benjamin; Watson, Simon J.; Alsahafi, Abdullah J.; Al Rabeeah, Abdullah A.; Corman, Victor Max; Sieberg, Andrea; Makhdoom, Hatem Q.; Assiri, Abdullah; Al Masri, Malaki; Aldabbagh, Souhaib; Bosch, Berend Jan|info:eu-repo/dai/nl/273306049; Beer, Martin; Müller, Marcel A.; Kellam, Paul; Drosten, Christian

    2014-01-01

    We investigated a case of human infection with Middle East respiratory syndrome coronavirus (MERS-CoV) after exposure to infected camels. Analysis of the whole human-derived virus and 15% of the camel-derived virus sequence yielded nucleotide polymorphism signatures suggestive of cross-species

  16. Antibodies against MERS coronavirus in dromedaries, United Arab Emirates, 2003 and 2013

    Meyer, Benjamin; Müller, Marcel A.; Corman, Victor M.; Reusken, Chantal B E M; Ritz, Daniel; Godeke, Gert Jan; Lattwein, Erik; Kallies, Stephan; Siemens, Artem; van Beek, Janko; Drexler, Jan F.; Muth, Doreen; Bosch, Berend Jan; Wernery, Ulrich; Koopmans, Marion P G; Wernery, Renate; Drosten, Christian

    2014-01-01

    Middle East respiratory syndrome coronavirus (MERS-CoV) has caused an ongoing outbreak of severe acute respiratory tract infection in humans in the Arabian Peninsula since 2012. Dromedary camels have been implicated as possible viral reservoirs. We used serologic assays to analyze 651 dromedary

  17. Reliable typing of MERS-CoV variants with a small genome fragment

    S.L. Smits (Saskia); V.S. Raj (Stalin); S.D. Pas (Suzan); C.B.E.M. Reusken (Chantal); K.A. Mohran (Khaled A.); E. Farag (Elmoubasher); H.E. Al Romaihi (Hamad); M.M. AlHajri (Mohd); B.L. Haagmans (Bart); M.P.G. Koopmans D.V.M. (Marion)

    2015-01-01

    textabstractBackground: Middle East Respiratory Syndrome coronavirus (. MERS-CoV) is an emerging pathogen that causes lower respiratory tract infection in humans. Camels are the likely animal source for zoonotic infection, although exact transmission modes remain to be determined. Human-to-human

  18. Isolation, identification and PCR amplification of merA gene from ...

    Mercury resistant Escherichia coli strains have been isolated from different mercury polluted sites of India and their minimum inhibitory concentration (MIC) levels were determined. The zone of inhibition was measured to find the antibiotic sensitivity level. The location of mer operon was determined by transforming the ...

  19. Fac–mer equilibria of coordinated iminodiacetate (ida ) in ternary Cu ...

    Unknown

    Keywords. Fac–mer equilibria; CuII-iminodiacetate-imidazole/benzimidazole ternary complexes; stability constants. 1. Introduction. Mixed ligand complexes of transition metal ions with amino acids, peptides or their derivatives or analogues, and heterocyclic N-bases can serve as model compounds of bioinorganic interests ...

  20. Feasibility of Using Convalescent Plasma Immunotherapy for MERS-CoV Infection, Saudi Arabia

    Hajeer, Ali H.; Luke, Thomas; Raviprakash, Kanakatte; Balkhy, Hanan; Johani, Sameera; Al-Dawood, Abdulaziz; Al-Qahtani, Saad; Al-Omari, Awad; Al-Hameed, Fahad; Hayden, Frederick G.; Fowler, Robert; Bouchama, Abderrezak; Shindo, Nahoko; Al-Khairy, Khalid; Carson, Gail; Taha, Yusri; Sadat, Musharaf; Alahmadi, Mashail

    2016-01-01

    We explored the feasibility of collecting convalescent plasma for passive immunotherapy of Middle East respiratory syndrome coronavirus (MERS-CoV) infection by using ELISA to screen serum samples from 443 potential plasma donors: 196 patients with suspected or laboratory-confirmed MERS-CoV infection, 230 healthcare workers, and 17 household contacts exposed to MERS-CoV. ELISA-reactive samples were further tested by indirect fluorescent antibody and microneutralization assays. Of the 443 tested samples, 12 (2.7%) had a reactive ELISA result, and 9 of the 12 had reactive indirect fluorescent antibody and microneutralization assay titers. Undertaking clinical trials of convalescent plasma for passive immunotherapy of MERS-CoV infection may be feasible, but such trials would be challenging because of the small pool of potential donors with sufficiently high antibody titers. Alternative strategies to identify convalescent plasma donors with adequate antibody titers should be explored, including the sampling of serum from patients with more severe disease and sampling at earlier points during illness. PMID:27532807

  1. 21 CFR 177.1040 - Acrylonitrile/styrene copoly-mer.

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Acrylonitrile/styrene copoly-mer. 177.1040 Section 177.1040 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) INDIRECT FOOD ADDITIVES: POLYMERS Substances for Use as Basic Components of Single and Repeated Use Food...

  2. Passivity Based Nonlinear Attitude Control of the Rømer Satellite

    Quottrup, Michael Melholt; Krogh-Sørensen, J.; Wisniewski, Rafal

    2001-01-01

    This paper suggests nonlinear attitude control of the Danish satellite Rømer. This satellite will be designed to fulfil two scientific objectives: The observation of stellar oscillations and the detection and localisation of gamma-ray bursts. The satellite will be equipped with a tetrahedron...

  3. Endogenous GAS6 and Mer receptor signaling regulate prostate cancer stem cells in bone marrow.

    Jung, Younghun; Decker, Ann M; Wang, Jingcheng; Lee, Eunsohl; Kana, Lulia A; Yumoto, Kenji; Cackowski, Frank C; Rhee, James; Carmeliet, Peter; Buttitta, Laura; Morgan, Todd M; Taichman, Russell S

    2016-05-03

    GAS6 and its receptors (Tryo 3, Axl, Mer or "TAM") are known to play a role in regulating tumor progression in a number of settings. Previously we have demonstrated that GAS6 signaling regulates invasion, proliferation, chemotherapy-induced apoptosis of prostate cancer (PCa) cells. We have also demonstrated that GAS6 secreted from osteoblasts in the bone marrow environment plays a critical role in establishing prostate tumor cell dormancy. Here we investigated the role that endogenous GAS6 and Mer receptor signaling plays in establishing prostate cancer stem cells in the bone marrow microenvironment.We first observed that high levels of endogenous GAS6 are expressed by disseminated tumor cells (DTCs) in the bone marrow, whereas relatively low levels of endogenous GAS6 are expressed in PCa tumors grown in a s.c. Interestingly, elevated levels of endogenous GAS6 were identified in putative cancer stem cells (CSCs, CD133+/CD44+) compared to non-CSCs (CD133-/CD44-) isolated from PCa/osteoblast cocultures in vitro and in DTCs isolated from the bone marrow 24 hours after intracardiac injection. Moreover, we found that endogenous GAS6 expression is associated with Mer receptor expression in growth arrested (G1) PCa cells, which correlates with the increase of the CSC populations. Importantly, we found that overexpression of GAS6 activates phosphorylation of Mer receptor signaling and subsequent induction of the CSC phenotype in vitro and in vivo.Together these data suggest that endogenous GAS6 and Mer receptor signaling contribute to the establishment of PCa CSCs in the bone marrow microenvironment, which may have important implications for targeting metastatic disease.

  4. Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S) Beyond the PhD Professional Development Program: A Pilot Project

    Johnson, A.; Jearld, A.; Williamson Whitney, V.; Huggans, M.; Ricciardi, L.; Thomas, S. H.; Jansma, P. E.

    2012-12-01

    professionals who are committed to achieving successful careers and supporting one another. This presentation will discuss outcomes from this pilot project, the use of social media to track and support ongoing MS PHD'S B-PhD activities, and "next steps" for the MS PHD'S B-PhD Professional Development Program.

  5. A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised with Acute Respiratory Disease Due to MERS Coronavirus or Other Causes.

    Musa A Garbati

    Full Text Available Middle East Respiratory syndrome (MERS first emerged in Saudi Arabia in 2012 and remains a global health concern. The objective of this study was to compare the clinical features and risk factors for adverse outcome in patients with RT-PCR confirmed MERS and in those with acute respiratory disease who were MERS-CoV negative, presenting to the King Fahad Medical City (KFMC in Riyadh between October 2012 and May 2014. The demographics, clinical and laboratory characteristics and clinical outcomes of patients with RT-PCR confirmed MERS-CoV infection was compared with those testing negative MERS-CoV PCR. Health care workers (HCW with MERS were compared with MERS patients who were not health care workers. One hundred and fifty nine patients were eligible for inclusion. Forty eight tested positive for MERS CoV, 44 (92% being hospital acquired infections and 23 were HCW. There were 111 MERS-CoV negative patients with acute respiratory illnesses included in this study as "negative controls". Patient with confirmed MERS-CoV infection were not clinically distinguishable from those with negative MERS-CoV RT-PCR results although diarrhoea was commoner in MERS patients. A high level of suspicion in initiating laboratory tests for MERS-CoV is therefore indicated. Variables associated with adverse outcome were older age and diabetes as a co-morbid illness. Interestingly, co-morbid illnesses other than diabetes were not significantly associated with poor outcome. Health care workers with MERS had a markedly better clinical outcome compared to non HCW MERS patients.

  6. Determination of fat content in chicken hamburgers using NIR spectroscopy and the Successive Projections Algorithm for interval selection in PLS regression (iSPA-PLS)

    Krepper, Gabriela; Romeo, Florencia; Fernandes, David Douglas de Sousa; Diniz, Paulo Henrique Gonçalves Dias; de Araújo, Mário César Ugulino; Di Nezio, María Susana; Pistonesi, Marcelo Fabián; Centurión, María Eugenia

    2018-01-01

    Determining fat content in hamburgers is very important to minimize or control the negative effects of fat on human health, effects such as cardiovascular diseases and obesity, which are caused by the high consumption of saturated fatty acids and cholesterol. This study proposed an alternative analytical method based on Near Infrared Spectroscopy (NIR) and Successive Projections Algorithm for interval selection in Partial Least Squares regression (iSPA-PLS) for fat content determination in commercial chicken hamburgers. For this, 70 hamburger samples with a fat content ranging from 14.27 to 32.12 mg kg- 1 were prepared based on the upper limit recommended by the Argentinean Food Codex, which is 20% (w w- 1). NIR spectra were then recorded and then preprocessed by applying different approaches: base line correction, SNV, MSC, and Savitzky-Golay smoothing. For comparison, full-spectrum PLS and the Interval PLS are also used. The best performance for the prediction set was obtained for the first derivative Savitzky-Golay smoothing with a second-order polynomial and window size of 19 points, achieving a coefficient of correlation of 0.94, RMSEP of 1.59 mg kg- 1, REP of 7.69% and RPD of 3.02. The proposed methodology represents an excellent alternative to the conventional Soxhlet extraction method, since waste generation is avoided, yet without the use of either chemical reagents or solvents, which follows the primary principles of Green Chemistry. The new method was successfully applied to chicken hamburger analysis, and the results agreed with those with reference values at a 95% confidence level, making it very attractive for routine analysis.

  7. Cultivation of hard-to-culture subsurface mercury-resistant bacteria and discovery of new merA gene sequences

    Rasmussen, L D; Zawadsky, C; Binnerup, S J

    2008-01-01

    different 16S rRNA gene sequences were observed, including Alpha-, Beta-, and Gammaproteobacteria; Actinobacteria; Firmicutes; and Bacteroidetes. The diversity of isolates obtained by direct plating included eight different 16S rRNA gene sequences (Alpha- and Betaproteobacteria and Actinobacteria). Partial...... sequencing of merA of selected isolates led to the discovery of new merA sequences. With phylum-specific merA primers, PCR products were obtained for Alpha- and Betaproteobacteria and Actinobacteria but not for Bacteroidetes and Firmicutes. The similarity to known sequences ranged between 89 and 95%. One...

  8. Modelling impacts of offshore wind farms on trophic web: the Courseulles-sur-Mer case study

    Raoux, Aurore; Pezy, Jean-Philippe; Dauvin, Jean-Claude; Tecchio, samuele; Degraer, Steven; Wilhelmsson, Dan; Niquil, Nathalie

    2016-04-01

    The French government is planning the construction of three offshore wind farms in Normandy. These offshore wind farms will integrate into an ecosystem already subject to a growing number of anthropogenic disturbances such as transportation, fishing, sediment deposit, and sediment extraction. The possible effects of this cumulative stressors on ecosystem functioning are still unknown, but they could impact their resilience, making them susceptible to changes from one stable state to another. Understanding the behaviour of these marine coastal complex systems is essential in order to anticipate potential state changes, and to implement conservation actions in a sustainable manner. Currently, there are no global and integrated studies on the effects of construction and exploitation of offshore wind farms. Moreover, approaches are generally focused on the conservation of some species or groups of species. Here, we develop a holistic and integrated view of ecosystem impacts through the use of trophic webs modelling tools. Trophic models describe the interaction between biological compartments at different trophic levels and are based on the quantification of flow of energy and matter in ecosystems. They allow the application of numerical methods for the characterization of emergent properties of the ecosystem, also called Ecological Network Analysis (ENA). These indices have been proposed as ecosystem health indicators as they have been demonstrated to be sensitive to different impacts on marine ecosystems. We present here in detail the strategy for analysing the potential environmental impacts of the construction of the Courseulles-sur-Mer offshore wind farm (Bay of Seine) such as the reef effect through the use of the Ecopath with Ecosim software. Similar Ecopath simulations will be made in the future on the Le Tréport offshore wind farm site. Results will contribute to a better knowledge of the impacts of the offshore wind farms on ecosystems. They also allow to

  9. Strategic Analysis for the MER Cape Verde Approach

    Gaines, Daniel; Belluta, Paolo; Herman, Jennifer; Hwang, Pauline; Mukai, Ryan; Porter, Dan; Jones, Byron; Wood, Eric; Grotzinger, John; Edgar, Lauren; hide

    2009-01-01

    The Mars Exploration Rover Opportunity has recently completed a two year campaign studying Victoria Crater. The campaign culminated in a close approach of Cape Verde in order to acquire high resolution imagery of the exposed stratigraphy in the cliff face. The close approach to Cape Verde provided significant challenges for every subsystem of the rover as the rover needed to traverse difficult, uncharacterised terrain and approach a cliff face with the potential of blocking out solar energy and communications with Earth. In this paper we describe the strategic analyses performed by the science and engineering teams so that we could successfully achieve the science objectives while keeping the rover safe.

  10. European Union funded project on the development of a whole complement deficiency screening ELISA-A story of success and an exceptional manager: Mohamed R. Daha.

    Würzner, Reinhard; Tedesco, Francesco; Garred, Peter; Mollnes, Tom Eirik; Truedsson, Lennart; Turner, Malcolm W; Sommarin, Yngve; Wieslander, Jörgen; Sim, Robert B

    2015-11-01

    A whole complement ELISA-based assay kit, primarily designed to screen for deficiencies in components of the complement system was developed during a European Union grant involving more than a dozen European scientists and a small-medium enterprise company (Wieslab, which later merged into Eurodiagnostica). The consortium was led by Prof. Mohamed R. Daha who had already guided a preceding European grant which prepared the ground for this endeavor to create a novel and sophisticated complement measurement tool. The final result of the grant was a scientific publication (Seelen et al., 2005, J. Immunol. Methods 296, 187-198) and a commercially available complement deficiency screening kit, WIESLAB(®) Complement system Screen. Thereafter, the group decided to carry on with a grant, located at Innsbruck Medical University, and supported by royalties and unrestricted educational grants from Eurodiagnostica, Malmö, entitled "Search for Applications for WIESLAB(®) Complement system Screen (SAW)" with the aim to look for further applications of this assay. During the latter project the group organized several scientific meetings aimed at evaluating the use of the assay as well as developing further branches of its platform. A look back over almost two decades reveals a great story of excellent research which was also commercially successful, fulfilling the aims of European Union grants. It is also a story of ageless friendship, only possible due to the vision and guidance of an exceptional manager: Moh Daha. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. Mer tyrosine kinase promotes the survival of t(1;19)-positive acute lymphoblastic leukemia (ALL) in the central nervous system (CNS).

    Krause, Sarah; Pfeiffer, Christian; Strube, Susanne; Alsadeq, Ameera; Fedders, Henning; Vokuhl, Christian; Loges, Sonja; Waizenegger, Jonas; Ben-Batalla, Isabel; Cario, Gunnar; Möricke, Anja; Stanulla, Martin; Schrappe, Martin; Schewe, Denis M

    2015-01-29

    Patients with t(1;19)-positive acute lymphoblastic leukemia (ALL) are prone to central nervous system (CNS) relapses, and expression of the TAM (Tyro3, Axl, and Mer) receptor Mer is upregulated in these leukemias. We examined the functional role of Mer in the CNS in preclinical models and performed correlative studies in 64 t(1;19)-positive and 93 control pediatric ALL patients. ALL cells were analyzed in coculture with human glioma cells and normal rat astrocytes: CNS coculture caused quiescence and protection from methotrexate toxicity in Mer(high) ALL cell lines, which was antagonized by short hairpin RNA-mediated knockdown of Mer. Mer expression was upregulated, prosurvival Akt and mitogen-activated protein kinase signaling were activated, and secretion of the Mer ligand Galectin-3 was stimulated. Mer(high) t(1;19) primary cells caused CNS involvement to a larger extent in murine xenografts than in their Mer(low) counterparts. Leukemic cells from Mer(high) xenografts showed enhanced survival in coculture. Treatment of Mer(high) patient cells with the Mer-specific inhibitor UNC-569 in vivo delayed leukemia onset, reduced CNS infiltration, and prolonged survival of mice. Finally, a correlation between high Mer expression and CNS positivity upon initial diagnosis was observed in t(1;19) patients. Our data provide evidence that Mer is associated with survival in the CNS in t(1;19)-positive ALL, suggesting a role as a diagnostic marker and therapeutic target. © 2015 by The American Society of Hematology.

  12. Strength and Deformability of Light-toned Layered Deposits Observed by MER Opportunity: Eagle to Erebus Craters

    Okubo, C. H.; Schultz, R. A.; Nahm, A. L.

    2007-07-01

    The strength and deformability of light-toned layered deposits are estimated based on measurements of porosity from Microscopic Imager data acquired by MER Opportunity during its traverse from Eagle Crater to Erebus Crater.

  13. Rezension: Ada Lovelace. Die Pionierin der Computertechnik und ihre Nachfolgerinnen von Sybille Krämer (Hg.)

    Bettina Schabschneider

    2015-01-01

    Ein aktueller von Sybille Krämer herausgegebener Sammelband beleuchtet die Bedeutung der Computertechnik-Pionierin Ada Lovelace. Bettina Schabschneider hat den Band einer detaillierten Lektüre unterzogen und für die MEDIENIMPULSE rezensiert …

  14. The Middle East respiratory syndrome coronavirus (MERS-CoV does not replicate in Syrian hamsters.

    Emmie de Wit

    Full Text Available In 2012 a novel coronavirus, MERS-CoV, associated with severe respiratory disease emerged in the Arabian Peninsula. To date, 55 human cases have been reported, including 31 fatal cases. Several of the cases were likely a result of human-to-human transmission. The emergence of this novel coronavirus prompts the need for a small animal model to study the pathogenesis of this virus and to test the efficacy of potential intervention strategies. In this study we explored the use of Syrian hamsters as a small animal disease model, using intratracheal inoculation and inoculation via aerosol. Clinical signs of disease, virus replication, histological lesions, cytokine upregulation nor seroconversion were observed in any of the inoculated animals, indicating that MERS-CoV does not replicate in Syrian hamsters.

  15. Vaccines for emerging infectious diseases: Lessons from MERS coronavirus and Zika virus

    Maslow, Joel N.

    2017-01-01

    ABSTRACT The past decade and a half has been characterized by numerous emerging infectious diseases. With each new threat, there has been a call for rapid vaccine development. Pathogens such as the Middle East Respiratory Syndrome coronavirus (MERS-CoV) and the Zika virus represent either new viral entities or viruses emergent in new geographic locales and characterized by novel complications. Both serve as paradigms for the global spread that can accompany new pathogens. In this paper, we review the epidemiology and pathogenesis of MERS-CoV and Zika virus with respect to vaccine development. The challenges in vaccine development and the approach to clinical trial design to test vaccine candidates for disease entities with a changing epidemiology are discussed. PMID:28846484

  16. Vaccines for emerging infectious diseases: Lessons from MERS coronavirus and Zika virus.

    Maslow, Joel N

    2017-12-02

    The past decade and a half has been characterized by numerous emerging infectious diseases. With each new threat, there has been a call for rapid vaccine development. Pathogens such as the Middle East Respiratory Syndrome coronavirus (MERS-CoV) and the Zika virus represent either new viral entities or viruses emergent in new geographic locales and characterized by novel complications. Both serve as paradigms for the global spread that can accompany new pathogens. In this paper, we review the epidemiology and pathogenesis of MERS-CoV and Zika virus with respect to vaccine development. The challenges in vaccine development and the approach to clinical trial design to test vaccine candidates for disease entities with a changing epidemiology are discussed.

  17. Improvement of an enzyme-linked immunosorbent assay for equine herpesvirus type 4 by using a synthetic-peptide 24-mer repeat sequence of glycoprotein G as an antigen

    BANNAI, Hiroshi; NEMOTO, Manabu; TSUJIMURA, Koji; YAMANAKA, Takashi; MAEDA, Ken; KONDO, Takashi

    2015-01-01

    To increase the sensitivity of an enzyme-linked immunosorbent assay (ELISA) for equine herpesvirus type 4 (EHV-4) that uses a 12-mer peptide of glycoprotein G (gG4-12-mer: MKNNPIYSEGSL) [4], we used a longer peptide consisting of a 24-mer repeat sequence (gG4-24-mer: MKNNPIYSEGSLMLNVQHDDSIHT) as an antigen. Sera of horses experimentally infected with EHV-4 reacted much more strongly to the gG4-24-mer peptide than to the gG4-12-mer peptide. We used peptide ELISAs to test paired sera from horses naturally infected with EHV-4 (n=40). gG4-24-mer ELISA detected 37 positive samples (92.5%), whereas gG4-12-mer ELISA detected only 28 (70.0%). gG4-24-mer ELISA was much more sensitive than gG4-12-mer ELISA. PMID:26424485

  18. Improvement of an enzyme-linked immunosorbent assay for equine herpesvirus type 4 by using a synthetic-peptide 24-mer repeat sequence of glycoprotein G as an antigen.

    Bannai, Hiroshi; Nemoto, Manabu; Tsujimura, Koji; Yamanaka, Takashi; Maeda, Ken; Kondo, Takashi

    2016-02-01

    To increase the sensitivity of an enzyme-linked immunosorbent assay (ELISA) for equine herpesvirus type 4 (EHV-4) that uses a 12-mer peptide of glycoprotein G (gG4-12-mer: MKNNPIYSEGSL) [4], we used a longer peptide consisting of a 24-mer repeat sequence (gG4-24-mer: MKNNPIYSEGSLMLNVQHDDSIHT) as an antigen. Sera of horses experimentally infected with EHV-4 reacted much more strongly to the gG4-24-mer peptide than to the gG4-12-mer peptide. We used peptide ELISAs to test paired sera from horses naturally infected with EHV-4 (n=40). gG4-24-mer ELISA detected 37 positive samples (92.5%), whereas gG4-12-mer ELISA detected only 28 (70.0%). gG4-24-mer ELISA was much more sensitive than gG4-12-mer ELISA.

  19. DIE RECHTSPOSITION DER EHRLICHEN UND UNEHRLICHEN BESITZER IN BEZUG AUF EIGENTÜMER

    Jadranko Jug

    2017-01-01

    Full Text Available Diese Arbeit beschäftigt sich mit den Problemen, die mit der rechtlichen Stellung ehrlicher und unehrlicher Besitzer im Verhältnis zum Eigentümer verbunden sind, d.h. sie analysiert die Rechte des Besitzers und die Forderungen, welche der Besitzer vom Eigentümer verlangen kann, damit der Besitzer sein Besitz abgibt. Im Gegensatz dazu werden die Rechte und Anforderungen des Eigentümers in Bezug auf ehrliche und unehrliche Besitzer analysiert. In der Praxis entstehen Dilemmas, wie die wesentlichen und vorteilhaften Ausgaben des ehrlichen Besitzers bestimmt werden, welche Voraussetzungen es sind und bis zu welchen Zeitpunkt das Zurückbehaltungsrecht für die Vergütung dieser Ausgaben ausgeübt werden kann, wann die Verjährungsfrist anfängt und von welcher Bedeutung die Bestimmungen des Zivilverfahrensgesetzes in Bezug auf die ungerechte Anreicherung, die Geschäftsführung ohne Anordnung oder das Zurückbehaltungsrecht sind und welche Bestimmungen diese und ähnliche Fragen regeln. Die Antworten auf einige von diesen Dilemmas sind in der Rechtsprechung vorgelegt, weshalb die Analyse und Forschung der Rechtsprechung, insbesondere Entscheidungen des Obersten Gerichtshofs der Republik Kroatien, die grundlegende Methode dieser Arbeit ist. In der Einführung bietet diese Artikel die grundlegenden Merkmale des Begriffs des Besitzens und des Eigentumsbesitzes und die Art und Qualität des Besitzes an, um eine Grundlage für die anschließende Analyse der Rechtsposition des Eigentumsbesitzers in Bezug auf den Eigentümer zu schaffen.

  20. A comparison of alternative 60-mer probe designs in an in-situ synthesized oligonucleotide microarray

    Fairbanks Benjamin D

    2006-04-01

    Full Text Available Abstract Background DNA microarrays have proven powerful for functional genomics studies. Several technologies exist for the generation of whole-genome arrays. It is well documented that 25mer probes directed against different regions of the same gene produce variable signal intensity values. However, the extent to which this is true for probes of greater length (60mers is not well characterized. Moreover, this information has not previously been reported for whole-genome arrays designed against bacteria, whose genomes may differ substantially in characteristics directly affecting microarray performance. Results We report here an analysis of alternative 60mer probe designs for an in-situ synthesized oligonucleotide array for the GC rich, β-proteobacterium Burkholderia cenocepacia. Probes were designed using the ArrayOligoSel3.5 software package and whole-genome microarrays synthesized by Agilent, Inc. using their in-situ, ink-jet technology platform. We first validated the quality of the microarrays as demonstrated by an average signal to noise ratio of >1000. Next, we determined that the variance of replicate probes (1178 total probes examined of identical sequence was 3.8% whereas the variance of alternative probes (558 total alternative probes examined designs was 9.5%. We determined that depending upon the definition, about 2.4% of replicate and 7.8% of alternative probes produced outlier conclusions. Finally, we determined none of the probe design subscores (GC content, internal repeat, binding energy and self annealment produced by ArrayOligoSel3.5 were predictive or probes that produced outlier signals. Conclusion Our analysis demonstrated that the use of multiple probes per target sequence is not essential for in-situ synthesized 60mer oligonucleotide arrays designed against bacteria. Although probes producing outlier signals were identified, the use of ratios results in less than 10% of such outlier conclusions. We also determined that

  1. Identification of species based on DNA barcode using k-mer feature vector and Random forest classifier.

    Meher, Prabina Kumar; Sahu, Tanmaya Kumar; Rao, A R

    2016-11-05

    DNA barcoding is a molecular diagnostic method that allows automated and accurate identification of species based on a short and standardized fragment of DNA. To this end, an attempt has been made in this study to develop a computational approach for identifying the species by comparing its barcode with the barcode sequence of known species present in the reference library. Each barcode sequence was first mapped onto a numeric feature vector based on k-mer frequencies and then Random forest methodology was employed on the transformed dataset for species identification. The proposed approach outperformed similarity-based, tree-based, diagnostic-based approaches and found comparable with existing supervised learning based approaches in terms of species identification success rate, while compared using real and simulated datasets. Based on the proposed approach, an online web interface SPIDBAR has also been developed and made freely available at http://cabgrid.res.in:8080/spidbar/ for species identification by the taxonomists. Copyright © 2016 Elsevier B.V. All rights reserved.

  2. Pharmacokinetics and Pharmacodynamics of a 13-mer LNA-inhibitor-miR-221 in Mice and Non-human Primates

    Maria Eugenia Gallo Cantafio

    2016-01-01

    Full Text Available Locked nucleic acid (LNA oligonucleotides have been successfully used to efficiently inhibit endogenous small noncoding RNAs in vitro and in vivo. We previously demonstrated that the direct miR-221 inhibition by the novel 13-mer LNA-i-miR-221 induces significant antimyeloma activity and upregulates canonical miR-221 targets in vitro and in vivo. To evaluate the LNA-i-miR-221 pharmacokinetics and pharmacodynamics, novel assays for oligonucleotides quantification in NOD.SCID mice and Cynomolgus monkeys (Macaca fascicularis plasma, urine and tissues were developed. To this aim, a liquid chromatography/mass spectrometry method, after solid-phase extraction, was used for the detection of LNA-i-miR-221 in plasma and urine, while a specific in situ hybridization assay for tissue uptake analysis was designed. Our analysis revealed short half-life, optimal tissue biovailability and minimal urine excretion of LNA-i-miR-221 in mice and monkeys. Up to 3 weeks, LNA-i-miR-221 was still detectable in mice vital organs and in xenografted tumors, together with p27 target upregulation. Importantly, no toxicity in the pilot monkey study was observed. Overall, our findings indicate the suitability of LNA-i-miR-221 for clinical use and we provide here pilot data for safety analysis and further development of LNA-miRNA-based therapeutics for human cancer.

  3. Thermophysical properties of the MER and Beagle II landing site regions on Mars

    Jakosky, Bruce M.; Hynek, Brian M.; Pelkey, Shannon M.; Mellon, Michael T.; Martínez-Alonso, Sara; Putzig, Nathaniel E.; Murphy, Nate; Christensen, Philip R.

    2006-08-01

    We analyzed remote-sensing observations of the Isidis Basin, Gusev Crater, and Meridiani Planum landing sites for Beagle II, MER-A Spirit, and MER-B Opportunity spacecraft, respectively. We emphasized the thermophysical properties using daytime and nighttime radiance measurements from the Mars Global Surveyor (MGS) Thermal Emission Spectrometer and Mars Odyssey Thermal Emission Imaging System (THEMIS) and thermal inertias derived from nighttime data sets. THEMIS visible images, MGS Mars Orbiter Camera (MOC) narrow-angle images, and MGS Mars Orbiter Laser Altimeter (MOLA) data are incorporated as well. Additionally, the remote-sensing data were compared with ground-truth at the MER sites. The Isidis Basin surface layer has been shaped by aeolian processes and erosion by slope winds coming off of the southern highlands and funneling through notches between massifs. In the Gusev region, surface materials of contrasting thermophysical properties have been interpreted as rocks or bedrock, duricrust, and dust deposits; these are consistent with a complex geological history dominated by volcanic and aeolian processes. At Meridiani Planum the many layers having different thermophysical and erosional properties suggest periodic deposition of differing sedimentological facies possibly related to clast size, grain orientation and packing, or mineralogy.

  4. Designing small universal k-mer hitting sets for improved analysis of high-throughput sequencing.

    Yaron Orenstein

    2017-10-01

    Full Text Available With the rapidly increasing volume of deep sequencing data, more efficient algorithms and data structures are needed. Minimizers are a central recent paradigm that has improved various sequence analysis tasks, including hashing for faster read overlap detection, sparse suffix arrays for creating smaller indexes, and Bloom filters for speeding up sequence search. Here, we propose an alternative paradigm that can lead to substantial further improvement in these and other tasks. For integers k and L > k, we say that a set of k-mers is a universal hitting set (UHS if every possible L-long sequence must contain a k-mer from the set. We develop a heuristic called DOCKS to find a compact UHS, which works in two phases: The first phase is solved optimally, and for the second we propose several efficient heuristics, trading set size for speed and memory. The use of heuristics is motivated by showing the NP-hardness of a closely related problem. We show that DOCKS works well in practice and produces UHSs that are very close to a theoretical lower bound. We present results for various values of k and L and by applying them to real genomes show that UHSs indeed improve over minimizers. In particular, DOCKS uses less than 30% of the 10-mers needed to span the human genome compared to minimizers. The software and computed UHSs are freely available at github.com/Shamir-Lab/DOCKS/ and acgt.cs.tau.ac.il/docks/, respectively.

  5. The effects of downwelling radiance on MER surface spectra: the evil that atmospheres do

    Wolff, M.; Ghosh, A.; Arvidson, R.; Christensen, P.; Guinness, E.; Ruff, S.; Seelos, F.; Smith, M.; Athena Science

    2004-11-01

    While it may not be surprising to some that downwelling radiation in the martian atmosphere may contribute a non-negligible fraction of the radiance for a given surface scene, others remain shocked and surprised (and often dismayed) to discover this fact; particularly with regard to mini-TES observations. Naturally, the relative amplitude of this sky ``contamination'' is often a complicated function of meteorological conditions, viewing geometry, surface properties, and (for the IR) surface temperature. Ideally, one would use a specialized observations to mimic the actual hemispherical-directional nature of the problem. Despite repeated attempts to obtain Pancam complete sky observations and mini-TES sky octants, such observations are not available in the MER observational database. As a result, one is left with the less-enviable, though certainly more computationally intensive, task of connecting point observations (radiance and derived meteorological parameters) to a hemispherical integral of downwelling radiance. Naturally, one must turn to a radiative transfer analysis, despite oft-repeated attempts to assert otherwise. In our presentation, we offer insight into the conditions under which one must worry about atmospheric removal, as well as semi-empirical approaches (based upon said radiative transfer efforts) for producing the correction factors from the available MER atmospheric observations. This work is proudly supported by the MER program through NASA/JPL Contract No. 1242889 (MJW), as well as the contracts for the co-authors.

  6. Overexpression of a bacterial mercury transporter MerT in Arabidopsis enhances mercury tolerance.

    Xu, Sheng; Sun, Bin; Wang, Rong; He, Jia; Xia, Bing; Xue, Yong; Wang, Ren

    2017-08-19

    The phytoremediation by using of green plants in the removal of environmental pollutant is an environment friendly, green technology that is cost effective and energetically inexpensive. By using Agrobacterium-mediated gene transfer, we generated transgenic Arabidopsis plants ectopically expressing mercuric transport protein gene (merT) from Pseudomonas alcaligenes. Compared with wild-type (WT) plants, overexpressing PamerT in Arabidopsis enhanced the tolerance to HgCl 2 . Further results showed that the enhanced total activities or corresponding transcripts of antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT) and guaiacol peroxidase (POD) were observed in transgenic Arabidopsis under HgCl 2 stress. These results were confirmed by the alleviation of oxidative damage, as indicated by the decrease of thiobarbituric acid reactive substances (TBARS) contents and reactive oxygen species (ROS) accumulation. In addition, localization analysis of PaMerT in Arabidopsis protoplast showed that it is likely to be associated with vacuole. In all, PamerT increased mercury (Hg) tolerance in transgenic Arabidopsis, and decreased production of Hg-induced ROS, thereby protecting plants from oxidative damage. The present study has provided further evidence that bacterial MerT plays an important role in the plant tolerance to HgCl 2 and in reducing the production of ROS induced by HgCl 2 . Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Avoiding student infection during a Middle East respiratory syndrome (MERS outbreak: a single medical school experience

    Seung Won Park

    2016-06-01

    Full Text Available Purpose: In outbreaks of infectious disease, medical students are easily overlooked in the management of healthcare personnel protection although they serve in clinical clerkships in hospitals. In the early summer of 2015, Middle East respiratory syndrome (MERS struck South Korea, and students of Sungkyunkwan University School of Medicine (SKKUSOM were at risk of contracting the disease. The purpose of this report is to share SKKUSOM’s experience against the MERS outbreak and provide suggestions for medical schools to consider in the face of similar challenges. Methods: Through a process of reflection-on-action, we examined SKKUSOM’s efforts to avoid student infection during the MERS outbreak and derived a few practical guidelines that medical schools can adopt to ensure student safety in outbreaks of infectious disease. Results: The school leadership conducted ongoing risk assessment and developed contingency plans to balance student safety and continuity in medical education. They rearranged the clerkships to another hospital and offered distant lectures and tutorials. Five suggestions are extracted for medical schools to consider in infection outbreaks: instant cessation of clinical clerkships; rational decision making on a school closure; use of information technology; constant communication with hospitals; and open communication with faculty, staff, and students. Conclusion: Medical schools need to take the initiative and actively seek countermeasures against student infection. It is essential that medical schools keep constant communication with their index hospitals and the involved personnel. In order to assure student learning, medical schools may consider offering distant education with online technology.

  8. Avoiding student infection during a Middle East respiratory syndrome (MERS) outbreak: a single medical school experience.

    Park, Seung Won; Jang, Hye Won; Choe, Yon Ho; Lee, Kyung Soo; Ahn, Yong Chan; Chung, Myung Jin; Lee, Kyu-Sung; Lee, Kyunghoon; Han, Taehee

    2016-06-01

    In outbreaks of infectious disease, medical students are easily overlooked in the management of healthcare personnel protection although they serve in clinical clerkships in hospitals. In the early summer of 2015, Middle East respiratory syndrome (MERS) struck South Korea, and students of Sungkyunkwan University School of Medicine (SKKUSOM) were at risk of contracting the disease. The purpose of this report is to share SKKUSOM's experience against the MERS outbreak and provide suggestions for medical schools to consider in the face of similar challenges. Through a process of reflection-on-action, we examined SKKUSOM's efforts to avoid student infection during the MERS outbreak and derived a few practical guidelines that medical schools can adopt to ensure student safety in outbreaks of infectious disease. The school leadership conducted ongoing risk assessment and developed contingency plans to balance student safety and continuity in medical education. They rearranged the clerkships to another hospital and offered distant lectures and tutorials. Five suggestions are extracted for medical schools to consider in infection outbreaks: instant cessation of clinical clerkships; rational decision making on a school closure; use of information technology; constant communication with hospitals; and open communication with faculty, staff, and students. Medical schools need to take the initiative and actively seek countermeasures against student infection. It is essential that medical schools keep constant communication with their index hospitals and the involved personnel. In order to assure student learning, medical schools may consider offering distant education with online technology.

  9. The Introduction of a Full Medication Review Process in a Local Hospital: Successes and Barriers of a Pilot Project in the Geriatric Ward

    Lies De Bock

    2018-02-01

    information. The communicative and non-communicative successes and hurdles encountered during this project need to be addressed in order to improve the full medication review process and to strengthen the role of the clinical pharmacist.

  10. A pandemic risk assessment of middle east respiratory syndrome coronavirus (MERS-CoV in Saudi Arabia

    Saleh A. Eifan

    2017-11-01

    Full Text Available Since the initial emergence of Middle East respiratory syndrome coronavirus (MERS-CoV in 2012, a high incidence rate has been observed in Saudi Arabia. This suggests that the country is at continuous risk. The epidemic level of MERS-CoV infection was examined in Saudi Arabia by the Susceptible-Infectious-Recovered (SIR model using a Bayesian approach for estimation of time dependent reproduction number (R across a two-year interval (May, 2013-May, 2015 in five defined clusters, followed by sensitivity analysis of the most significant clusters. Significant MERS-CoV peaks were detected in the period between March and May of each year. Moreover, MERS-CoV infection was highlighted in western (40.8% and central (31.9% regions, followed by eastern region (20%. The temporal-based Bayesian approach indicated a sub-critical epidemic in all regions in the baseline scenario (R: 0.85–0.97. However, R potential limit was exceeded in the sensitivity analysis scenario in only central and western regions (R: 1.08–1.12 that denoted epidemic level in those regions. The impact of sporadic cases was found relatively insignificant and pinpointed to the lack of zoonotic influence on MERS-CoV transmission dynamics. The results of current study would be helpful for evaluation of future progression of MERS-CoV infections, better understanding and control interventions.

  11. Conserved antigenic sites between MERS-CoV and Bat-coronavirus are revealed through sequence analysis.

    Sharmin, Refat; Islam, Abul B M M K

    2016-01-01

    MERS-CoV is a newly emerged human coronavirus reported closely related with HKU4 and HKU5 Bat coronaviruses. Bat and MERS corona-viruses are structurally related. Therefore, it is of interest to estimate the degree of conserved antigenic sites among them. It is of importance to elucidate the shared antigenic-sites and extent of conservation between them to understand the evolutionary dynamics of MERS-CoV. Multiple sequence alignment of the spike (S), membrane (M), enveloped (E) and nucleocapsid (N) proteins was employed to identify the sequence conservation among MERS and Bat (HKU4, HKU5) coronaviruses. We used various in silico tools to predict the conserved antigenic sites. We found that MERS-CoV shared 30 % of its S protein antigenic sites with HKU4 and 70 % with HKU5 bat-CoV. Whereas 100 % of its E, M and N protein's antigenic sites are found to be conserved with those in HKU4 and HKU5. This sharing suggests that in case of pathogenicity MERS-CoV is more closely related to HKU5 bat-CoV than HKU4 bat-CoV. The conserved epitopes indicates their evolutionary relationship and ancestry of pathogenicity.

  12. Ingredients for successful partnerships

    S.M. Pfisterer (Stella)

    2011-01-01

    textabstractFor the development of new cross-sector partnerships it is required to know what the essence of successful partnership projects is. Which factors influence success or failure of partnerships is highly related to the specific context where partnerships operate. The literature on critical

  13. Managing one thousand designs documents: what the success of project has about that?; Gerenciando mil documentos de projetos: o que o sucesso do empreendimento tem com isso?

    Oliveira, Ailton C.; Pio, Bruno P. [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil)

    2008-07-01

    Project Management Techniques based on PMI- Project Management Institute have become widely disseminated with showing results in performance improvements. In this paper is presented the improvement obtained in supervising projects in gas pipeline network deployments in Northeast of Brazil by the use of project good practices. The clear definition of project phases; the use of integrated management system; the application of check lists and the prioritization of the issue/approval of documents are examples of tools that impact on the processes of management, with emphasis on control of scope, time, quality and communication. To evaluate the results obtained with the use of these tools is made a comparison between the project of deployment of City Gates TermoFortaleza (CE) and Pedras de Fogo (PB), both belonging to the Program Extension of network Northeast pipeline. (author)

  14. Evaluation of the Vocational Preparation and Success of Handicapped Individuals Who Reside in Rural Areas of Florida. Florida Rural Research Project. Final Report.

    Budd, Diane M.

    Phase 2 of a three-phase project examined the secondary education background and employment adjustment of handicapped youth in rural counties in Florida. (Phase 1 was a pilot study.) Subjects were former special education students in five rural project counties who had been identified as needing services in the area of educable mental retardation,…

  15. Emotional confidence levels and success of tourism development for poverty reduction: The South African Kwam eMakana home-stay project.

    Kwaramba, H.M.; Lovett, Jonathan Cranidge; Louw, L.; Chipumuro, J.

    2012-01-01

    Poverty reduction is a central component of South African government local economic development (LED) programmes. The Grahamstown Kwame Makana pilot project for promotion of tourism homestays aims to assist disadvantaged women to become self-reliant entrepreneurs. However the project has only met

  16. Molecular dynamics of Middle East Respiratory Syndrome Coronavirus (MERS CoV) fusion heptad repeat trimers

    Kandeel, Mahmoud

    2018-05-17

    Structural studies related to Middle East Respiratory Syndrome Coronavirus (MERS CoV) infection process are so limited. In this study, molecular dynamics (MD) simulation was carried out to unravel changes in the MERS CoV heptad repeat domains (HRs) and factors affecting fusion state HR stability. Results indicated that HR trimer is more rapidly stabilized, having stable system energy and lowest root mean square deviations (RMSDs). While trimers were the predominant active form of CoVs HR, monomers were also discovered in both of viral and cellular membranes. In order to find the differences between S2 monomer and trimer molecular dynamics, S2 monomer were modelled and subjected to MD simulation. In contrast to S2 trimer, S2 monomer was unstable, having high RMSDs with major drifts above 8 Å. Fluctuation of HR residue positions revealed major changes in the C-terminal of HR2 and the linker coil between HR1 and HR2 in both monomer and trimer. Hydrophobic residues at the “a” and “d” positions of HR helices stabilize the whole system, having minimal changes in RMSD. The global distance test and contact area difference scores support instability of MERS CoV S2 monomer. Analysis of HR1-HR2 inter-residue contacts and interaction energy revealed three different energy scales along HR helices. Two strong interaction energies were identified at the start of the HR2 helix and at the C-terminal of HR2. The identified critical residues by MD simulation and residues at a and d position of HR helix were strong stabilizers of HRs recognition.

  17. A Computational Approach for Predicting Role of Human MicroRNAs in MERS-CoV Genome

    Md Mahmudul Hasan

    2014-01-01

    Full Text Available The new epidemic Middle East Respiratory Syndrome (MERS is caused by a type of human coronavirus called MERS-CoV which has global fatality rate of about 30%. We are investigating potential antiviral therapeutics against MERS-CoV by using host microRNAs (miRNAs which may downregulate viral gene expression to quell viral replication. We computationally predicted potential 13 cellular miRNAs from 11 potential hairpin sequences of MERS-CoV genome. Our study provided an interesting hypothesis that those miRNAs, that is, hsa-miR-628-5p, hsa-miR-6804-3p, hsa-miR-4289, hsa-miR-208a-3p, hsa-miR-510-3p, hsa-miR-18a-3p, hsa-miR-329-3p, hsa-miR-548ax, hsa-miR-3934-5p, hsa-miR-4474-5p, hsa-miR-7974, hsa-miR-6865-5p, and hsa-miR-342-3p, would be antiviral therapeutics against MERS-CoV infection.

  18. MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape

    Menachery, Vineet D.; Schafer, Alexandra; Burnum-Johnson, Kristin E.; Mitchell, Hugh D.; Eisfeld-Fenney, Amie J.; Walters, Kevin B.; Nicora, Carrie D.; Purvine, Samuel O.; Casey, Cameron P.; Monroe, Matthew E.; Weitz, Karl K.; Stratton, Kelly G.; Webb-Robertson, Bobbie-Jo M.; Gralinski, Lisa; Metz, Thomas O.; Smith, Richard D.; Waters, Katrina M.; Sims, Amy C.; Kawaoka, Yoshihiro; Baric, Ralph

    2018-01-16

    Convergent evolution dictates that diverse groups of viruses will target both similar and distinct host pathways in order to manipulate the immune response and improve infection. In this study, we sought to leverage this uneven viral antagonism to identify critical host factors that govern disease outcome. Utilizing a systems based approach, we examined differential regulation of IFNγ dependent genes following infection with highly pathogenic viruses including influenza (H5N1-VN1203, H1N1-CA04) and coronaviruses (SARS-CoV, MERS-CoV). Categorizing by function, we observed down regulation of genes associated with antigen presentation following both H5N1-VN1203 and MERS-CoV infection. Further examination revealed global down regulation of antigen presentation genes and was confirmed by proteomics for both H5N1-VN1203 and MERS-CoV infection. Importantly, epigenetic analysis suggested that DNA methylation rather than histone modification plays a crucial role in MERS-CoV mediated antagonism of antigen presentation genes; in contrast, H5N1-VN1203 likely utilizes a combination of epigenetic mechanisms to target antigen presentation. Together, the results indicate a common approach utilized by H5N1-VN1203 and MERS-CoV to modulate antigen presentation and the host adaptive immune response.

  19. Insularité et démographie dans la mer Intérieure japonaise

    Philippe PELLETIER

    1992-12-01

    Full Text Available Les îles éloignées (ritô tiennent une place importante dans l’espace japonais. Les îles de la mer Intérieure se dépeuplèrent fortement pendant la Haute Croissance. Un graphique corrélant leur évolution démographique et leur distance par rapport à Honshû et Shikoku nous aide à comprendre que l’éloignement insulaire joua un rôle relatif.

  20. How big is too big or how many partners are needed to build a large project which still can be managed successfully?

    Henkel, Daniela; Eisenhauer, Anton

    2017-04-01

    During the last decades, the number of large research projects has increased and therewith the requirement for multidisciplinary, multisectoral collaboration. Such complex and large-scale projects pose new competencies to form, manage, and use large, diverse teams as a competitive advantage. For complex projects the effort is magnified because multiple large international research consortia involving academic and non-academic partners, including big industries, NGOs, private and public bodies, all with cultural differences, individually discrepant expectations on teamwork and differences in the collaboration between national and multi-national administrations and research organisations, challenge the organisation and management of such multi-partner research consortia. How many partners are needed to establish and conduct collaboration with a multidisciplinary and multisectoral approach? How much personnel effort and what kinds of management techniques are required for such projects. This presentation identifies advantages and challenges of large research projects based on the experiences made in the context of an Innovative Training Network (ITN) project within Marie Skłodowska-Curie Actions of the European HORIZON 2020 program. Possible strategies are discussed to circumvent and avoid conflicts already at the beginning of the project.

  1. Business Intelligence Success Factors

    Gaardboe, Rikke; Jonasen, Tanja Svarre

    2018-01-01

    Business intelligence (BI) is a strategically important practice in many organizations. Several studies have investigated the factors that contribute to BI success; however, an overview of the critical success factors (CSFs) involved is lacking in the extant literature. We have integrated...... 34 CSFs related to BI success. The distinct CSFs identified in the extant literature relate to project management skills (13 papers), management support (20 papers), and user involvement (11 papers). In the articles with operationalized BI success, we found several distinct factors: system quality...

  2. Comparing the Reproductive Success of Yakima River Hatchery- and Wild-Origin Spring Chinook; Yakima/Klickitat Fisheries Project Monitoring and Evaluation, 2005-2006 Annual Report.

    Schroder, S.L.; Pearsons, T.N. (Washington Department of Fish and Wildlife, Olympia, WA); Knudsen, C.M. (Oncorh Consulting, Olympia, WA)

    2006-05-01

    Reproductive success in wild- and first generation hatchery-origin spring Chinook males was examined by allowing the fish to compete for spawning opportunities in two sections of an observation stream. Behavioral observations were used to characterize the frequency of aggression and courting activities. Microsatellite DNA from each male and fry collected from the observation stream were used in pedigree analyses to estimate reproductive success. The coefficient of variation in male reproductive success equaled 116 and 86% in the two populations. No differences were detected in reproductive success due to hatchery or wild origin. Nor were any behavioral differences found between hatchery and wild males. Although statistical power was low due to intrinsic variation a great deal of overlap existed in the reproductive success values of hatchery and wild males. Significant disparities existed among the males on their ability to produce offspring. Males achieving high reproductive success mated with numerous females, were socially dominant, aggressive, and tended to stay in localized areas, courting and spawning with females that were adjacent to one another.

  3. European collider's success provides a blueprint for mega-science projects 35 countries contribute labor and money to build a physics facility too costly for any one nation

    MacDonald, K

    1999-01-01

    Many scientists believe the construction of the LHC could become the blueprint for future international collaborations on large-scale scientific facilities and projects too large and costly for individual countries to fund alone (2 pages).

  4. Success factors for sustainable private business operation of decentralised rural electrification with PV - Results from the project "DELTA PRO RES" in the lower Delta Mekong countries

    Gölz, S.; Vogt, G.; Maigne, Y.; Mozas, K.

    2006-01-01

    The project Delta PRO RES is the response to the wave of electricity sector reform in developing countries in South East Asia which provides opportunities for a new approach: bankable rural electrification. The project prepares the ground for this future track by developing a methodology and markets to increase rural access to energy with decentralized renewable energy systems in the Lower Delta Mekong countries Vietnam, Cambodia and Lao PDR. Private entrepreneurship and venture capital inves...

  5. Renewable energies in the French DOM-TOM : a study of the costs and benefits of transitioning from fossil fuels to renewable energies in the French Départements d’Outre Mer et Territoires d’Outre Mer

    Stanley-Smith, Adam P.

    2010-01-01

    The French Départements d’Outre Mer et Territoires d’Outre Mer (DOM-TOM) are not the most populous region of France. Nor are they the most prosperous, the most important, or even centers of industrial production. Rather, the DOM-TOM possessions have a unique value in French culture: they represent the past glory of the state and its people, and the courage that lead French explorers and settlers to roam the world. Unfortunately, the DOM-TOM represents an ever growing burden upon...

  6. Tendência empreendedora do gerente: uma análise de sua relevância para o sucesso de projetos inovadores Manager entrepreneur tendency: an analysis of its relevance to innovative projects success

    Rosária de Fátima Segger Macri Russo

    2007-12-01

    Full Text Available O gerente de projeto, no seu papel de liderança, é um elemento-chave, tanto para o sucesso dos empreendimentos que coordena, quanto para a implementação das estratégias das organizações. Adicionalmente, pode se tornar importante para o futuro da organização, ao usar sua capacidade empreendedora para vislumbrar novas necessidades e oportunidades. No entanto, o gerente de projetos tem responsabilidades operacionais, de planejamento, monitoramento, contabilização e controle do projeto, que muitas vezes contrastam com as características de um empreendedor. Ante essas visões contraditórias sobre o gerente de projetos torna-se relevante avaliar se as características de um empreendedor quando incorporadas no perfil de um gerente se refletem em projetos mais bem sucedidos do ponto de vista empresarial. Para esta avaliação, foi feita uma pesquisa de campo com 164 gerentes de projetos, em sua maioria homens, com estudos de pós-graduação e bastante experientes. A análise não-paramétrica indicou uma tendência de se ter projetos mais bem sucedidos quanto maior for a tendência empreendedora do gerente de projetos. Houve um destaque para a tendência criativa, para a qual se pôde observar um impacto positivo sobre inúmeros critérios de sucesso.A project manager as a leader is the key element to assure the success of the ventures he/she is responsible for and to implement the organization strategies. Besides, the project manager can be very important to the future of the organization by applying entrepreneur skills aiming at needs and new opportunities. However, he/she has operational responsibilities such as planning, monitoring, and accounting and control of the project which can, some times, conflict with characteristics of an entrepreneur. Therefore, it is relevant to evaluate whether a project manager has the required entrepreneur skills which when combined the skills of a manger result in successful projects. In order to

  7. Overview of preparedness and response for Middle East respiratory syndrome coronavirus (MERS-CoV in Oman

    I.S. Al-Abaidani

    2014-12-01

    Full Text Available Several countries in the Middle East and around 22 countries worldwide have reported cases of human infection with the Middle East respiratory syndrome coronavirus (MERS-CoV. The exceptionally high fatality rate resulting from MERS-CoV infection in conjunction with the paucity of knowledge about this emerging virus has led to major public and international concern. Within the framework of the national acute respiratory illness surveillance, the Ministry of Health in the Sultanate of Oman has announced two confirmed cases of MERS-CoV to date. The aim of this report is to describe the epidemiological aspects of these two cases and to highlight the importance of public health preparedness and response. The absence of secondary cases among contacts of the reported cases can be seen as evidence of the effectiveness of infection prevention and control precautions as an important pillar of the national preparedness and response plan applied in the health care institutions in Oman.

  8. Crystallization and preliminary X-ray diffraction data of an LNA 7-mer duplex derived from a ricin aptamer

    Förster, Charlotte; Oberthuer, Dominik; Gao, Jiang; Eichert, André; Quast, Frederick G.; Betzel, Christian; Nitsche, Andreas; Erdmann, Volker A.; Fürste, Jens P.

    2009-01-01

    An all-LNA duplex was designed from the stem region of an RNA aptamer which has been generated against ricin. The LNA duplex was crystallized and preliminary X-ray diffraction analysis revealed diffraction to a resolution of up to 2.8 Å. Locked nucleic acids (LNAs) are modified nucleic acids which contain a modified sugar such as β-d-2′-O,4′-C methylene-bridged ribofuranose or other sugar derivatives in LNA analogues. The β-d-2′-O,4′-C methylene ribofuranose LNAs in particular possess high stability and melting temperatures, which makes them of interest for stabilizing the structure of different nucleic acids. Aptamers, which are DNAs or RNAs targeted against specific ligands, are candidates for substitution with LNAs in order to increase their stability. A 7-mer helix derived from the terminal part of an aptamer that was targeted against ricin was chosen. The ricin aptamer originally consisted of natural RNA building blocks and showed high affinity in ricin binding. For future stabilization of the aptamer, the terminal helix has been constructed as an ‘all-locked’ LNA and was successfully crystallized in order to investigate its structural properties. Optimization of crystal growth succeeded by the use of different metal salts as additives, such as CuCl 2 , MgCl 2 , MnCl 2 , CaCl 2 , CoCl 2 and ZnSO 4 . Preliminary X-ray diffraction data were collected and processed to 2.8 Å resolution. The LNA crystallized in space group P6 5 , with unit-cell parameters a = 50.11, b = 50.11, c = 40.72 Å. The crystals contained one LNA helix per asymmetric unit with a Matthews coefficient of 3.17 Å 3 Da −1 , which implies a solvent content of 70.15%

  9. OPTIMAL REPRESENTATION OF MER SIGNALS APPLIED TO THE IDENTIFICATION OF BRAIN STRUCTURES DURING DEEP BRAIN STIMULATION

    Hernán Darío Vargas Cardona

    2015-07-01

    Full Text Available Identification of brain signals from microelectrode recordings (MER is a key procedure during deep brain stimulation (DBS applied in Parkinson’s disease patients. The main purpose of this research work is to identify with high accuracy a brain structure called subthalamic nucleus (STN, since it is the target structure where the DBS achieves the best therapeutic results. To do this, we present an approach for optimal representation of MER signals through method of frames. We obtain coefficients that minimize the Euclidean norm of order two. From optimal coefficients, we extract some features from signals combining the wavelet packet and cosine dictionaries. For a comparison frame with the state of the art, we also process the signals using the discrete wavelet transform (DWT with several mother functions. We validate the proposed methodology in a real data base. We employ simple supervised machine learning algorithms, as the K-Nearest Neighbors classifier (K-NN, a linear Bayesian classifier (LDC and a quadratic Bayesian classifier (QDC. Classification results obtained with the proposed method improves significantly the performance of the DWT. We achieve a positive identification of the STN superior to 97,6%. Identification outcomes achieved by the MOF are highly accurate, as we can potentially get a false positive rate of less than 2% during the DBS.

  10. A novel k-mer set memory (KSM) motif representation improves regulatory variant prediction.

    Guo, Yuchun; Tian, Kevin; Zeng, Haoyang; Guo, Xiaoyun; Gifford, David Kenneth

    2018-04-13

    The representation and discovery of transcription factor (TF) sequence binding specificities is critical for understanding gene regulatory networks and interpreting the impact of disease-associated noncoding genetic variants. We present a novel TF binding motif representation, the k -mer set memory (KSM), which consists of a set of aligned k -mers that are overrepresented at TF binding sites, and a new method called KMAC for de novo discovery of KSMs. We find that KSMs more accurately predict in vivo binding sites than position weight matrix (PWM) models and other more complex motif models across a large set of ChIP-seq experiments. Furthermore, KSMs outperform PWMs and more complex motif models in predicting in vitro binding sites. KMAC also identifies correct motifs in more experiments than five state-of-the-art motif discovery methods. In addition, KSM-derived features outperform both PWM and deep learning model derived sequence features in predicting differential regulatory activities of expression quantitative trait loci (eQTL) alleles. Finally, we have applied KMAC to 1600 ENCODE TF ChIP-seq data sets and created a public resource of KSM and PWM motifs. We expect that the KSM representation and KMAC method will be valuable in characterizing TF binding specificities and in interpreting the effects of noncoding genetic variations. © 2018 Guo et al.; Published by Cold Spring Harbor Laboratory Press.

  11. Application of State Analysis and Goal-based Operations to a MER Mission Scenario

    Morris, John Richard; Ingham, Michel D.; Mishkin, Andrew H.; Rasmussen, Robert D.; Starbird, Thomas W.

    2006-01-01

    State Analysis is a model-based systems engineering methodology employing a rigorous discovery process which articulates operations concepts and operability needs as an integrated part of system design. The process produces requirements on system and software design in the form of explicit models which describe the system behavior in terms of state variables and the relationships among them. By applying State Analysis to an actual MER flight mission scenario, this study addresses the specific real world challenges of complex space operations and explores technologies that can be brought to bear on future missions. The paper first describes the tools currently used on a daily basis for MER operations planning and provides an in-depth description of the planning process, in the context of a Martian day's worth of rover engineering activities, resource modeling, flight rules, science observations, and more. It then describes how State Analysis allows for the specification of a corresponding goal-based sequence that accomplishes the same objectives, with several important additional benefits.

  12. Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody.

    Katherine V Houser

    2017-08-01

    Full Text Available The Middle East respiratory syndrome coronavirus (MERS-CoV is a zoonotic betacoronavirus that was first detected in humans in 2012 as a cause of severe acute respiratory disease. As of July 28, 2017, there have been 2,040 confirmed cases with 712 reported deaths. While many infections have been fatal, there have also been a large number of mild or asymptomatic cases discovered through monitoring and contact tracing. New Zealand white rabbits are a possible model for asymptomatic infection with MERS-CoV. In order to discover more about non-lethal infections and to learn whether a single infection with MERS-CoV would protect against reinfection, we inoculated rabbits with MERS-CoV and monitored the antibody and inflammatory response. Following intranasal infection, rabbits developed a transient dose-dependent pulmonary infection with moderately high levels of viral RNA, viral antigen, and perivascular inflammation in multiple lung lobes that was not associated with clinical signs. The rabbits developed antibodies against viral proteins that lacked neutralizing activity and the animals were not protected from reinfection. In fact, reinfection resulted in enhanced pulmonary inflammation, without an associated increase in viral RNA titers. Interestingly, passive transfer of serum from previously infected rabbits to naïve rabbits was associated with enhanced inflammation upon infection. We further found this inflammation was accompanied by increased recruitment of complement proteins compared to primary infection. However, reinfection elicited neutralizing antibodies that protected rabbits from subsequent viral challenge. Our data from the rabbit model suggests that people exposed to MERS-CoV who fail to develop a neutralizing antibody response, or persons whose neutralizing antibody titers have waned, may be at risk for severe lung disease on re-exposure to MERS-CoV.

  13. Identification of residues on human receptor DPP4 critical for MERS-CoV binding and entry

    Song, Wenfei [Ministry of Education Key Laboratory of Protein Science, Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084 (China); Wang, Ying [Comprehensive AIDS Research Center, Research Center for Public Health, School of Medicine, Tsinghua University, Beijing 100084 (China); Wang, Nianshuang; Wang, Dongli [Ministry of Education Key Laboratory of Protein Science, Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084 (China); Guo, Jianying; Fu, Lili [Comprehensive AIDS Research Center, Research Center for Public Health, School of Medicine, Tsinghua University, Beijing 100084 (China); Shi, Xuanling, E-mail: shixuanlingsk@tsinghua.edu.cn [Comprehensive AIDS Research Center, Research Center for Public Health, School of Medicine, Tsinghua University, Beijing 100084 (China)

    2014-12-15

    Middle East respiratory syndrome coronavirus (MERS-CoV) infects host cells through binding the receptor binding domain (RBD) on its spike glycoprotein to human receptor dipeptidyl peptidase 4 (hDPP4). Here, we report identification of critical residues on hDPP4 for RBD binding and virus entry through analysis of a panel of hDPP4 mutants. Based on the RBD–hDPP4 crystal structure we reported, the mutated residues were located at the interface between RBD and hDPP4, which potentially changed the polarity, hydrophobic or hydrophilic properties of hDPP4, thereby interfering or disrupting their interaction with RBD. Using surface plasmon resonance (SPR) binding analysis and pseudovirus infection assay, we showed that several residues in hDPP4–RBD binding interface were important on hDPP4–RBD binding and viral entry. These results provide atomic insights into the features of interactions between hDPP4 and MERS-CoV RBD, and also provide potential explanation for cellular and species tropism of MERS-CoV infection. - Highlights: • It has been demonstrated that MERS-CoV infects host cells through binding its envelope spike (S) glycoprotein to the host cellular receptor dipeptidyl peptidase 4 (DPP4). • To identify the critical residues on hDPP4 for RBD binding and virus entry, we constructed a panel of hDPP4 mutants based on structure-guided mutagenesis. • Using surface plasmon resonance (SPR) binding analysis and pseudovirus infection assay, we showed that several residues on hDPP4 had significant impacts on virus/receptor interactions and viral entry. • Our study has provided new insights into the features of interactions between hDPP4 and MERS-CoV RBD, and provides potential explanation for cellular and species tropism of MERS-CoV infection.

  14. Les experiències artístiques en l'espai públic. Art efímer com a catàlisi de la vida urbana

    Lucila Urda Peña

    2016-06-01

    Full Text Available L'art efímer urbà, com a corrent d'expressió de pensament col·lectiu és una font de generació de projectes comunitaris en què els ciutadans poden recuperar "l'experiència de ciutat". La profusió de diverses manifestacions d'art efímer en ciutats de tot el món des de començaments del segle XXI està tenint conseqüències en l'espai urbà tant a nivell local com a nivell global. Una d'elles és la transformació del paisatge urbà, cada vegada més considerat com a escenari visible en projectes de regeneració urbana. A més de la transformació física també es produeixen canvis en les dinàmiques urbanes ja que els efectes de les intervencions tenen conseqüències més enllà dels canvis d'imatge. Els efectes socioeconòmics locals o fins i tot globals de les transformacions lligades a l'art efímer són cada vegada més evidents. Aquest article relata l'origen i desenvolupament de diverses manifestacions artístiques urbanes i reflexiona sobre les seves conseqüències en la vida urbana com a eina de transformació física i social.

  15. The Role of Social Work for Foreign Residents in an Epidemic: The MERS Crisis in the Republic of Korea.

    Park, Hong-Jae; Lee, Bong Joo

    2016-01-01

    This article explores the experiences of foreign residents during the period of the Middle East Respiratory Syndrome (MERS) outbreak in (South) Korea and discusses from a social work perspective the implications of their experiences and their needs. Data were obtained from interviews with 22 foreigners who either live and work or study in Korea. The data were then interpreted using a thematic analysis approach in a multilingual research context. The findings from the study show that foreign residents experienced a wide range of social and psychoemotional difficulties during the MERS health threat. Implications for social work practice in an epidemic emergency are presented.

  16. Merónimos de la gastronomía costarricense: Limón y Valle Central

    Leoni de León, Jorge Antonio; Barahona Gamboa, Hazel

    2016-01-01

    Resumen La definición de un platillo culinario implica la descripción de sus partes, dentro de las cuales podemos incluir los ingredientes; por ejemplo, la carne es parte de un estofado. En este sentido, los ingredientes son merónimos y, además, pueden ser objeto de una clasificación según el proceso al que están sometidos en la receta; es decir, si son mezclados, hervidos, horneados, polvoreados, cortados, etc. Así, nos avocamos a establecer y clasificar los merónimos, según estos criterios,...

  17. MERS-CoV at the Animal-Human interface: inputs on exposure pathways from an Expert-Opinion elicitation

    Anna Funk

    2016-10-01

    Full Text Available Nearly four years after the first report of the emergence of Middle-East respiratory syndrome Coronavirus (MERS-CoV and nearly 1800 human cases later, the ecology of MERS-CoV, its epidemiology, and risk factors of MERS-CoV transmission between camels are poorly understood. Knowledge about the pathways and mechanisms of transmission from animals to humans is limited; as of yet, transmission risks have not been quantified. Moreover the divergent sanitary situations and exposures to animals among populations in the Arabian Peninsula, where human primary cases appear to dominate, vs. other regions in the Middle East and Africa, with no reported human clinical cases and where the virus has been detected only in dromedaries, represents huge scientific and health challenges. Here, we have used expert opinion elicitation in order to obtain ideas on relative importance of MERS-CoV risk factors and estimates of transmission risks from various types of contact between humans and dromedaries. Fourteen (14 experts with diverse and extensive experience in MERS-CoV relevant fields were enrolled and completed an online questionnaire that examined pathways based on several scenarios e.g. camels-camels, camels-human, bats/other species to camels/humans and the role of diverse biological substances (milk, urine etc. and potential fomites.Experts believed that dromedary camels play the largest role in MERS-CoV infection of other dromedaries; however, they also indicated a significant influence of the season (i.e. calving or weaning periods on transmission risk. All experts thought that MERS-CoV infected dromedaries and asymptomatic humans play the most important role in infection of humans, with bats and other species presenting a possible, but yet undefined, risk. Direct and indirect contact of humans with dromedary camels were identified as the most risky types of contact, when compared to consumption of various camel products, with estimated 'most

  18. Distinct immune response in two MERS-CoV-infected patients: can we go from bench to bedside?

    Emmanuel Faure

    Full Text Available One year after the occurrence of the first case of infection by the Middle East Respiratory Syndrome coronavirus (MERS-CoV there is no clear consensus on the best treatment to propose. The World Health Organization, as well as several other national agencies, are still working on different clinical approaches to implement the most relevant treatment in MERS-CoV infection. We compared innate and adaptive immune responses of two patients infected with MERS-CoV to understand the underlying mechanisms involved in the response and propose potential therapeutic approaches. Broncho-alveolar lavage (BAL of the first week and sera of the first month from the two patients were used in this study. Quantitative polymerase chain reaction (qRTPCR was performed after extraction of RNA from BAL cells of MERS-CoV infected patients and control patients. BAL supernatants and sera were used to assess cytokines and chemokines secretion by enzyme-linked immunosorbent assay. The first patient died rapidly after 3 weeks in the intensive care unit, the second patient still recovers from infection. The patient with a poor outcome (patient 1, compared to patient 2, did not promote type-1 Interferon (IFN, and particularly IFNα, in response to double stranded RNA (dsRNA from MERS-CoV. The absence of IFNα, known to promote antigen presentation in response to viruses, impairs the development of a robust antiviral adaptive Th-1 immune response. This response is mediated by IL-12 and IFNγ that decreases viral clearance; levels of both of these mediators were decreased in patient 1. Finally, we confirm previous in vitro findings that MERS-CoV can drive IL-17 production in humans. Host recognition of viral dsRNA determines outcome in the early stage of MERS-CoV infection. We highlight the critical role of IFNα in this initial stage to orchestrate a robust immune response and bring substantial arguments for the indication of early IFNα treatment during MERS-CoV infection.

  19. MERS-CoV: Middle East respiratory syndrome corona virus: Can radiology be of help? Initial single center experience

    Hamimi, Ahmed

    2016-01-01

    Human infection with a novel coronavirus named Middle East respiratory syndrome coronavirus (MERS-CoV) was first identified in Saudi Arabia and the Middle East in September, 2012. The aim of this study was to establish the most pathognomonic radiological sign(s) to diagnose MERS CoV. Patients and methods: This is a retrospective descriptive study. All patients were subjected to serial X-ray. High resolution non-contrast CT chest was also obtained for 10 patients. The scans were reviewed fo...

  20. Project Management

    Pilkington, Alan; Chai, Kah-Hin; Le, Yang

    2015-01-01

    This paper identifies the true coverage of PM theory through a bibliometric analysis of the International Journal of Project Management from 1996-2012. We identify six persistent research themes: project time management, project risk management, programme management, large-scale project management......, project success/failure and practitioner development. These differ from those presented in review and editorial articles in the literature. In addition, topics missing from the PM BOK: knowledge management project-based organization and project portfolio management have become more popular topics...

  1. Accurate approximation method for prediction of class I MHC affinities for peptides of length 8, 10 and 11 using prediction tools trained on 9mers

    Lundegaard, Claus; Lund, Ole; Nielsen, Morten

    2008-01-01

    Several accurate prediction systems have been developed for prediction of class I major histocompatibility complex (MHC):peptide binding. Most of these are trained on binding affinity data of primarily 9mer peptides. Here, we show how prediction methods trained on 9mer data can be used for accurate...

  2. 'Adotta scienza e arte nella tua classe': The results of a successfully teaching project which combines science with art

    Giansanti, S.

    2015-01-01

    The project called 'Adotta scienza e arte nella tua classe' ('Adopt Science and Art in your class'), on the interconnection between science and art, has been addressed to the Italian secondary middle and high school involving more than 200 teachers and about 2200 students. The main purpose of this project is to make the young students aware of the strong link between science and art is a unique cultural and interdisciplinary occasion. To reach this goal, the Adotta project asked students to produce an artwork inspired by the interpretation of a quotation among a hundred commented quotes by physicists, mathematicians, scientist, writers, artists, accompanied by an original short sentence written by students themselves. More than 1000 artworks have been produced and collected in two galleries on Facebook. From their analysis emerges the students’ feeling about science, which is usually associated to human brain, based on mathematical laws and related to technological progress, but it is also a powerful tool that should be responsibly used. This project also valorizes teachers’ role in scientific education through activities that encourage students to recognize science in every aspect of their lives.

  3. An Intervention for Early Mathematical Success: Outcomes from the Hybrid Version of the Building Math Readiness Parents as Partners (MRPP) Project

    Kritzer, Karen L.; Pagliaro, Claudia M.

    2013-01-01

    The Building Math Readiness in Young Deaf/Hard-of-Hearing Children: Parents as Partners (MRPP) Project works with parents to increase the understanding of foundational mathematics concepts in their preschool deaf/hard-of-hearing (d/hh) children in preparation for formal mathematics education. A multiple-case/single-unit case study incorporating…

  4. Are High Achievers Successful in Collaborative Learning? An Explorative Study of College Students' Learning Approaches in Team Project-Based Learning

    Lee, Hye-Jung; Kim, Hyekyung; Byun, Hyunjung

    2017-01-01

    This study analyses how high-achieving students approach team project-based learning (TPBL) and aims to identify the implications and challenges of TPBL practice in higher education. After interviewing 32 high-achieving students and surveying 1022 additional students at a South Korean university, we found that four factors were particularly…

  5. Prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Abu Dhabi Emirate, United Arab Emirates.

    Yusof, Mohammed F; Eltahir, Yassir M; Serhan, Wissam S; Hashem, Farouk M; Elsayed, Elsaeid A; Marzoug, Bahaaeldin A; Abdelazim, Assem Si; Bensalah, Oum Keltoum A; Al Muhairi, Salama S

    2015-06-01

    High seroprevalence of Middle East respiratory syndrome corona virus (MERS-CoV) in dromedary camels has been previously reported in United Arab Emirates (UAE). However, the molecular detection of the virus has never been reported before in UAE. Of the 7,803 nasal swabs tested in the epidemiological survey, MERS-CoV nucleic acid was detected by real-time PCR in a total of 126 (1.6 %) camels. Positive camels were detected at the borders with Saudi Arabia and Oman and in camels' slaughter houses. MERS-CoV partial sequences obtained from UAE camels were clustering with human- and camel-derived MERS-CoV sequences in the same geographic area. Results provide further evidence of MERS-CoV zoonosis.

  6. Composite Risers for Deepwater Applications Risers composites pour applications en mer profonde

    Metivaud G.

    2006-11-01

    Full Text Available This paper is devoted to the high performance composite tubes developed by the Institut Français du Pétrole (IFP and Aerospatiale for deepwater risers applications. The design principles of the tubes are first presented, along with results of preliminary work carried out as part of the initial feasibility study. Applications of composite tubes to drilling riser Kill and Choke lines and to TLP production risers, both of which have been studied in detail, are then described. Technical and operational advantages obtained from such applications are discussed. Cet article présente les travaux réalisés par l'Institut Français du Pétrole et l'Aerospatiale dans le domaine des tubes composites haute performance pour les applications aux liaisons fond-surface de forage et de production en mer profonde. Les matériaux composites avancés sont une classe de matériaux très particulière, présentant à la fois des caractéristiques mécaniques élevées et une densité spécifique faible. Ils sont utilisés principalement par les industries de l'aéronautique et de l'espace, mais l'industrie pétrolière en mer profonde est un secteur où ils peuvent trouver dans l'avenir des applications très intéressantes, notamment les tubes de risers. Les tubes de risers pétroliers en mer présentent en effet une gamme de spécifications élevées (diamètres, pression, traction, fatigue dans un environnement sévère et leur poids suspendu peut pénaliser fortement les systèmes de forage ou de production par grande profondeur d'eau. Un premier concept de tube composite haute performance a été développé par IFP et Aerospatiale au début des années 1980 ; sa partie courante, réalisée par enroulement filamentaire de fibres de verre R ou de fibres de carbone, et son système d'embout ont été soumis à une série d'essais mécaniques (pression interne jusqu'à 105 MPa, traction supérieure à 1 000 kN pour un diamètre nominal de 0,1 m, millions de

  7. The prevalence of Middle East respiratory Syndrome coronavirus (MERS-CoV) infection in livestock and temporal relation to locations and seasons.

    Kasem, Samy; Qasim, Ibrahim; Al-Doweriej, Ali; Hashim, Osman; Alkarar, Ali; Abu-Obeida, Ali; Saleh, Mohamed; Al-Hofufi, Ali; Al-Ghadier, Hussein; Hussien, Raed; Al-Sahaf, Ali; Bayoumi, Faisal; Magouz, Asmaa

    2018-01-29

    The Middle East respiratory syndrome (MERS) has been reported for the first time infecting a human being since 2012. The WHO was notified of 27 countries have reported cases of MERS, the majority of these cases occur in the Arabian Peninsula, particularly in Saudi Arabia. Dromedary camels are likely to be the main source of Middle East respiratory syndrome virus (MERS-CoV) infection in humans. MERS-CoV infection rates among camels in livestock markets and slaughterhouses were investigated in Saudi Arabia. A total of 698 nasal swabs were collected and examined with Rapid assay and rtRT-PCR. Ten MERS-CoV positive samples were subjected to full genomic sequencing. In addition, the sensitivity and specificity of the Rapid immunochromatographic assay (BioNote, South Korea) was evaluated as a diagnostic tool for MERS-CoV compared to rtRT-PCR. The results showed a high percentage of dromedaries (56.4%) had evidence for nasal MERS-CoV infection. Phylogenetic analysis of the ten MERS-CoV isolates showed that the sequences were closely related to the other MERS-CoV strains recovered from camels and human cases. Moreover, the results showed that 195 samples were positive for MERS-CoV by rapid assay compared to 394 positive samples of rtRT-PCR, which showed low rapid assay sensitivity (49.49%) while, the specificity were found to be 100%. These findings indicate that these sites are a highly-hazardous to zoonotic diseases. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

  8. Environmental Conditions Constrain the Distribution and Diversity of Archaeal merA in Yellowstone National Park, Wyoming, U.S.A.

    Wang, Y.; Boyd, E.; Crane, S.; Lu-Irving, P.; Krabbenhoft, D.; King, S.; Dighton, J.; Geesey, G.; Barkay, T.

    2011-01-01

    The distribution and phylogeny of extant protein-encoding genes recovered from geochemically diverse environments can provide insight into the physical and chemical parameters that led to the origin and which constrained the evolution of a functional process. Mercuric reductase (MerA) plays an integral role in mercury (Hg) biogeochemistry by catalyzing the transformation of Hg(II) to Hg(0). Putative merA sequences were amplified from DNA extracts of microbial communities associated with mats and sulfur precipitates from physicochemically diverse Hg-containing springs in Yellowstone National Park, Wyoming, using four PCR primer sets that were designed to capture the known diversity of merA. The recovery of novel and deeply rooted MerA lineages from these habitats supports previous evidence that indicates merA originated in a thermophilic environment. Generalized linear models indicate that the distribution of putative archaeal merA lineages was constrained by a combination of pH, dissolved organic carbon, dissolved total mercury and sulfide. The models failed to identify statistically well supported trends for the distribution of putative bacterial merA lineages as a function of these or other measured environmental variables, suggesting that these lineages were either influenced by environmental parameters not considered in the present study, or the bacterial primer sets were designed to target too broad of a class of genes which may have responded differently to environmental stimuli. The widespread occurrence of merA in the geothermal environments implies a prominent role for Hg detoxification in these environments. Moreover, the differences in the distribution of the merA genes amplified with the four merA primer sets suggests that the organisms putatively engaged in this activity have evolved to occupy different ecological niches within the geothermal gradient. ?? 2011 Springer Science+Business Media, LLC.

  9. Environmental conditions constrain the distribution and diversity of archaeal merA in Yellowstone National Park, Wyoming, U.S.A.

    Wang, Yanping; Boyd, Eric; Crane, Sharron; Lu-Irving, Patricia; Krabbenhoft, David; King, Susan; Dighton, John; Geesey, Gill; Barkay, Tamar

    2011-11-01

    The distribution and phylogeny of extant protein-encoding genes recovered from geochemically diverse environments can provide insight into the physical and chemical parameters that led to the origin and which constrained the evolution of a functional process. Mercuric reductase (MerA) plays an integral role in mercury (Hg) biogeochemistry by catalyzing the transformation of Hg(II) to Hg(0). Putative merA sequences were amplified from DNA extracts of microbial communities associated with mats and sulfur precipitates from physicochemically diverse Hg-containing springs in Yellowstone National Park, Wyoming, using four PCR primer sets that were designed to capture the known diversity of merA. The recovery of novel and deeply rooted MerA lineages from these habitats supports previous evidence that indicates merA originated in a thermophilic environment. Generalized linear models indicate that the distribution of putative archaeal merA lineages was constrained by a combination of pH, dissolved organic carbon, dissolved total mercury and sulfide. The models failed to identify statistically well supported trends for the distribution of putative bacterial merA lineages as a function of these or other measured environmental variables, suggesting that these lineages were either influenced by environmental parameters not considered in the present study, or the bacterial primer sets were designed to target too broad of a class of genes which may have responded differently to environmental stimuli. The widespread occurrence of merA in the geothermal environments implies a prominent role for Hg detoxification in these environments. Moreover, the differences in the distribution of the merA genes amplified with the four merA primer sets suggests that the organisms putatively engaged in this activity have evolved to occupy different ecological niches within the geothermal gradient.

  10. Effects of a Technology Supported Project Based Learning (TS-PBL Approach on the Success of a Mobile Application Development Course and the Students’ Opinions

    Fezile Ozdamli

    2017-05-01

    Full Text Available Similar to traditional desktop software development processes, teamwork is a necessity in the mobile application development process. Thus, the aim of this study is to examine the effects of the technology supported project-based learning approach in mobile application development courses on the academic achievement of students and to clarify the engineering students’ opinions. A total of 130 engineering students from the Department taking mobile application development courses were the participants of this study. The lessons progressed in one group in the form of technology supported project-based learning steps, while in the other group, they were conducted using traditional methods. Based on the results, the practical implementation of a mobile application with a TS-PBL approach in engineering students’ education will be discussed.

  11. Successful Project Based Learning (PBL) Across Disciplines Geared Towards Middle School: An Example from a Wetlands PBL Unit in Reno, Nevada, USA

    Howard, K. L.; Suchy-Mabrouk, A.; Noble, P. J.; Mensing, S. A.; Ewing-Taylor, J.

    2014-12-01

    A growing need for broad dissemination of current scientific research and improved scientific literacy requires new models of professional development that allow for direct collaboration between educators and university researchers. One example is a project funded by the National Science Foundation (NSF) as part of a study titled, "Reconstructing 2500 years of environmental change at the periphery of Rome: Integrating paleoecology and socioeconomic history to understand human response to climate." This project involves a team of middle school teachers working with researchers at the University of Nevada, Reno (UNR) to gain first-hand knowledge in multidisciplinary research connecting science and society, and applies a similar approach in the classroom. In 2013, the team's science teacher traveled to Italy as a member of the science research group. A series of workshops introduced the remaining teachers to the research project. Teachers collaborated to develop a Project Based Learning (PBL) unit that incorporated Next Generation Science Standards and encompassed English, Social Studies, Math, and Science curricula using a pedagogical approach different from the single subject-based PBL's usually taught in their school district. The PBL unit draws on the NSF study and focuses on exploring the balance between economic and environmental issues surrounding local wetlands. In May 2014, 160 middle school students worked in groups to create and test a question about physio-chemical parameters in a nearby wetland and used these data to discuss local economic development. Initially, students claimed polarized views of environmental issues or economic development interests; however, during a multimedia session showcasing results, students communicated more informed perspectives that clearly incorporated knowledge gained from their own research. Some students were able to make recommendations for good practices involving planned economic development near the wetland

  12. Project ethics

    Jonasson, Haukur Ingi

    2013-01-01

    How relevant is ethics to project management? The book - which aims to demystify the field of ethics for project managers and managers in general - takes both a critical and a practical look at project management in terms of success criteria, and ethical opportunities and risks. The goal is to help the reader to use ethical theory to further identify opportunities and risks within their projects and thereby to advance more directly along the path of mature and sustainable managerial practice.

  13. No MERS-CoV but positive influenza viruses in returning Hajj pilgrims, China, 2013–2015

    Xuezheng Ma

    2017-11-01

    Full Text Available Abstract Background There is global health concern that the mass movement of pilgrims to and from Mecca annually could contribute to the international spread of Middle East Respiratory Syndrome Coronavirus (MERS-CoV. In China, about 11,000 Muslim pilgrims participate in the Hajj gathering in Mecca annually. This is the first report of MERS-CoV and respiratory virus molecular screening of returning pilgrims at points of entry in China from 2013 to 2015. Methods and results A total of 847 returning Hajj pilgrims participated in this study. The test results indicated that of the travelers, 34 tested positive for influenza A virus, 14 for influenza B virus, 4 for metapneumo virus, 2 for respiratory syncytial virus, and 3 for human coronavirus. There was a significant difference in the rates of positive and negative influenza virus tests between Hajj pilgrims with symptoms and those without. The detection rates of influenza virus were not significantly different among the three years studied, at 5.3, 6.0 and 6.3% for 2013, 2014 and 2015, respectively. Discussion and conclusion The MERS-CoV and respiratory viruses detection results at points of entry in China from 2013 to 2015 indicated that there were no MERS-CoV infection but a 5.7% positive influenza viruses in returning Chinese pilgrims.

  14. Searching for animal models and potential target species for emerging pathogens: Experience gained from Middle East respiratory syndrome (MERS coronavirus

    Júlia Vergara-Alert

    2017-06-01

    Full Text Available Emerging and re-emerging pathogens represent a substantial threat to public health, as demonstrated with numerous outbreaks over the past years, including the 2013–2016 outbreak of Ebola virus in western Africa. Coronaviruses are also a threat for humans, as evidenced in 2002/2003 with infection by the severe acute respiratory syndrome coronavirus (SARS-CoV, which caused more than 8000 human infections with 10% fatality rate in 37 countries. Ten years later, a novel human coronavirus (Middle East respiratory syndrome coronavirus, MERS-CoV, associated with severe pneumonia, arose in the Kingdom of Saudi Arabia. Until December 2016, MERS has accounted for more than 1800 cases and 35% fatality rate. Finding an animal model of disease is key to develop vaccines or antivirals against such emerging pathogens and to understand its pathogenesis. Knowledge of the potential role of domestic livestock and other animal species in the transmission of pathogens is of importance to understand the epidemiology of the disease. Little is known about MERS-CoV animal host range. In this paper, experimental data on potential hosts for MERS-CoV is reviewed. Advantages and limitations of different animal models are evaluated in relation to viral pathogenesis and transmission studies. Finally, the relevance of potential new target species is discussed.

  15. Tuning in and catching on? Examining the relationship between pandemic communication and awareness and knowledge of MERS in the USA.

    Lin, Leesa; McCloud, Rachel F; Bigman, Cabral A; Viswanath, Kasisomayajula

    2017-06-01

    Large-scale influenza outbreaks over the last decade, such as SARS and H1N1, have brought to global attention the importance of emergency risk communication and prompted the international community to develop communication responses. Since pandemic outbreaks are relatively infrequent, there is a dearth of evidence addressing the following questions: (i) Have the resources invested in strategic and routine communication for past pandemic outbreaks yielded public health preparedness benefits? (ii) Have past efforts sensitized people to pay attention to new pandemic threats? The Middle East Respiratory Syndrome (MERS) that was followed closely by major media outlets in the USA provides an opportunity to examine the relationship between exposure to public communication about epidemics and public awareness and knowledge about new risks. In December, 2013, we surveyed a nationally representative sample of 627 American adults and examined the associations between people's awareness to prior pandemics and their awareness of and knowledge about MERS. Awareness of prior pandemics was significantly associated with awareness and knowledge of MERS. The most common sources from which people first heard about MERS were also identified. Communication inequalities were observed between racial/ethnic and socioeconomic positions, suggesting a need for more effective pandemic communication. © The Author 2016. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  16. A camel-derived MERS-CoV with a variant spike protein cleavage site and distinct fusion activation properties

    Millet, Jean Kaoru; Goldstein, Monty E; Labitt, Rachael N; Hsu, Hung-Lun; Daniel, Susan; Whittaker, Gary R

    2016-01-01

    Middle East respiratory syndrome coronavirus (MERS-CoV) continues to circulate in both humans and camels, and the origin and evolution of the virus remain unclear. Here we characterize the spike protein of a camel-derived MERS-CoV (NRCE-HKU205) identified in 2013, early in the MERS outbreak. NRCE-HKU205 spike protein has a variant cleavage motif with regard to the S2′ fusion activation site—notably, a novel substitution of isoleucine for the otherwise invariant serine at the critical P1′ cleavage site position. The substitutions resulted in a loss of furin-mediated cleavage, as shown by fluorogenic peptide cleavage and western blot assays. Cell–cell fusion and pseudotyped virus infectivity assays demonstrated that the S2′ substitutions decreased spike-mediated fusion and viral entry. However, cathepsin and trypsin-like protease activation were retained, albeit with much reduced efficiency compared with the prototypical EMC/2012 human strain. We show that NRCE-HKU205 has more limited fusion activation properties possibly resulting in more restricted viral tropism and may represent an intermediate in the complex pattern of MERS-CoV ecology and evolution. PMID:27999426

  17. Adaptive evolution influences the infectious dose of MERS-CoV necessary to achieve severe respiratory disease.

    Douglas, Madeline G; Kocher, Jacob F; Scobey, Trevor; Baric, Ralph S; Cockrell, Adam S

    2018-04-01

    We recently established a mouse model (288-330 +/+ ) that developed acute respiratory disease resembling human pathology following infection with a high dose (5 × 10 6 PFU) of mouse-adapted MERS-CoV (icMERSma1). Although this high dose conferred fatal respiratory disease in mice, achieving similar pathology at lower viral doses may more closely reflect naturally acquired infections. Through continued adaptive evolution of icMERSma1 we generated a novel mouse-adapted MERS-CoV (maM35c4) capable of achieving severe respiratory disease at doses between 10 3 and 10 5 PFU. Novel mutations were identified in the maM35c4 genome that may be responsible for eliciting etiologies of acute respiratory distress syndrome at 10-1000 fold lower viral doses. Importantly, comparative genetics of the two mouse-adapted MERS strains allowed us to identify specific mutations that remained fixed through an additional 20 cycles of adaptive evolution. Our data indicate that the extent of MERS-CoV adaptation determines the minimal infectious dose required to achieve severe respiratory disease. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Rezension: Ada Lovelace. Die Pionierin der Computertechnik und ihre Nachfolgerinnen von Sybille Krämer (Hg.

    Bettina Schabschneider

    2015-12-01

    Full Text Available Ein aktueller von Sybille Krämer herausgegebener Sammelband beleuchtet die Bedeutung der Computertechnik-Pionierin Ada Lovelace. Bettina Schabschneider hat den Band einer detaillierten Lektüre unterzogen und für die MEDIENIMPULSE rezensiert …

  19. Adaptation aux répercussions de l'élévation du niveau de la mer ...

    , la pollution, l'utilisation intensive des terres, la croissance démographique et la dégradation des écosystèmes. Elles sont par ailleurs exposées aux répercussions de la hausse du niveau de la mer et notamment aux inondations. Réduire la ...

  20. MERS-CoV: Middle East respiratory syndrome corona virus: Can radiology be of help? Initial single center experience

    Ahmed Hamimi

    2016-03-01

    Conclusions: MERS CoV virus may have a specific pattern in chest X-ray and CT developing a single or multiple opacities progressing into a widespread multifocal bilateral patches of ground glass opacities or confluent consolidation resembling organizing pneumonia.

  1. 77 FR 49059 - Requested Administrative Waiver of the Coastwise Trade Laws: Vessel CHAT DE MER; Invitation for...

    2012-08-15

    ... Administrative Waiver of the Coastwise Trade Laws: Vessel CHAT DE MER; Invitation for Public Comments AGENCY....gov . SUPPLEMENTARY INFORMATION: As described by the applicant the intended service of the vessel CHAT... Francisco Bay. Geographic Region: ``California.'' The complete application is given in DOT docket MARAD-2012...

  2. Modelling air pollution transfers in the Fos-Sur-Mer area

    Dibi, Niagne Martin

    1985-01-01

    A 'puff' gaussian model with determined standard deviations based on transfer times of two classes of vertical stability of the atmosphere was developed in order to evaluate the atmospheric dispersion of industrial discharges in the Fos-sur-Mer area. This research was carried out within the framework of a large study for the processing of the data obtained during the measurement campaign organized by the European Communities. The model in its analytic form allows consideration of the main phenomena which modify the puff content during the transfer: reflectance, wet and dry deposition, physical-chemical transformation of the pollutant SO 2 . The model includes the site meteorological parameters measured in three dimensions (wind speed and direction at ground level and in altitude) and the characteristics of the different stacks. It can also calculate pollutions resulting from a short emission or from continuous emissions. Examples are presented. (author) [fr

  3. Passivity based nonlinear attitude control of the Rømer satellite

    Quottrup, Michael Melholt; Krogh-Sørensen, J.; Wisniewski, Rafal

    This paper suggests nonlinear attitude control of the Danish satellite Rømer. This satellite will be designed to fulfil two scientific objectives: The observation of stellar oscillations and the detection and localisation of gamma-ray bursts. The satellite will be equipped with a tetrahedron...... configuration of Wide Angle Telescopes for Cosmic Hard x-rays (WATCH), that server the dual purpose of X-ray detectors and momentum wheels. By employing passivity theory it is shown, that the satellite is a passive system. This paper shows, that global asymptotic can be obtained with a passive and an imput...... and output strictly passive system in a feedback interconnection. It is demonstrated in a simulation study that the resultant control has a potential for on-board implementation in the acquistion phase, where global stabillity of the control law is vital...

  4. Specific and selective target detection of supra-genome 21 Mers Salmonella via silicon nanowires biosensor

    Mustafa, Mohammad Razif Bin; Dhahi, Th S.; Ehfaed, Nuri. A. K. H.; Adam, Tijjani; Hashim, U.; Azizah, N.; Mohammed, Mohammed; Noriman, N. Z.

    2017-09-01

    The nano structure based on silicon can be surface modified to be used as label-free biosensors that allow real-time measurements. The silicon nanowire surface was functionalized using 3-aminopropyltrimethoxysilane (APTES), which functions as a facilitator to immobilize biomolecules on the silicon nanowire surface. The process is simple, economical; this will pave the way for point-of-care applications. However, the surface modification and subsequent detection mechanism still not clear. Thus, study proposed step by step process of silicon nano surface modification and its possible in specific and selective target detection of Supra-genome 21 Mers Salmonella. The device captured the molecule with precisely; the approach took the advantages of strong binding chemistry created between APTES and biomolecule. The results indicated how modifications of the nanowires provide sensing capability with strong surface chemistries that can lead to specific and selective target detection.

  5. Project financing

    Cowan, A.

    1998-01-01

    Project financing was defined ('where a lender to a specific project has recourse only to the cash flow and assets of that project for repayment and security respectively') and its attributes were described. Project financing was said to be particularly well suited to power, pipeline, mining, telecommunications, petro-chemicals, road construction, and oil and gas projects, i.e. large infrastructure projects that are difficult to fund on-balance sheet, where the risk profile of a project does not fit the corporation's risk appetite, or where higher leverage is required. Sources of project financing were identified. The need to analyze and mitigate risks, and being aware that lenders always take a conservative view and gravitate towards the lowest common denominator, were considered the key to success in obtaining project financing funds. TransAlta Corporation's project financing experiences were used to illustrate the potential of this source of financing

  6. Acute viral respiratory infections among children in MERS-endemic Riyadh, Saudi Arabia, 2012-2013.

    Fagbo, Shamsudeen F; Garbati, Musa A; Hasan, Rami; AlShahrani, Dayel; Al-Shehri, Mohamed; AlFawaz, Tariq; Hakawi, Ahmed; Wani, Tariq Ahmad; Skakni, Leila

    2017-02-01

    The emergence of the Middle East Respiratory Syndrome (MERS) in Saudi Arabia has intensified focus on Acute Respiratory Infections [ARIs]. This study sought to identify respiratory viruses (RVs) associated with ARIs in children presenting at a tertiary hospital. Children (aged ≤13) presenting with ARI between January 2012 and December 2013 tested for 15 RVs using the Seeplex R RV15 kit were retrospectively included. Epidemiological data was retrieved from patient records. Of the 2235 children tested, 61.5% were ≤1 year with a male: female ratio of 3:2. Viruses were detected in 1364 (61.02%) children, 233 (10.4%) having dual infections: these viruses include respiratory syncytial virus (RSV) (24%), human rhinovirus (hRV) (19.7%), adenovirus (5.7%), influenza virus (5.3%), and parainfluenzavirus-3 (4.6%). Children, aged 9-11 months, were most infected (60.9%). Lower respiratory tract infections (55.4%) were significantly more than upper respiratory tract infection (45.3%) (P < 0.001). Seasonal variation of RV was directly and inversely proportional to relative humidity and temperature, respectively, for non MERS coronaviruses (NL63, 229E, and OC43). The study confirms community-acquired RV associated with ARI in children and suggests modulating roles for abiotic factors in RV epidemiology. However, community-based studies are needed to elucidate how these factors locally influence RV epidemiology. J. Med. Virol. 89:195-201, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  7. Conceptual Design and Architecture of Mars Exploration Rover (MER) for Seismic Experiments Over Martian Surfaces

    Garg, Akshay; Singh, Amit

    2012-07-01

    Keywords: MER, Mars, Rover, Seismometer Mars has been a subject of human interest for exploration missions for quite some time now. Both rover as well as orbiter missions have been employed to suit mission objectives. Rovers have been preferentially deployed for close range reconnaissance and detailed experimentation with highest accuracy. However, it is essential to strike a balance between the chosen science objectives and the rover operations as a whole. The objective of this proposed mechanism is to design a vehicle (MER) to carry out seismic studies over Martian surface. The conceptual design consists of three units i.e. Mother Rover as a Surrogate (Carrier) and Baby Rovers (two) as seeders for several MEMS-based accelerometer / seismometer units (Nodes). Mother Rover can carry these Baby Rovers, having individual power supply with solar cells and with individual data transmission capabilities, to suitable sites such as Chasma associated with Valles Marineris, Craters or Sand Dunes. Mother rover deploys these rovers in two opposite direction and these rovers follow a triangulation pattern to study shock waves generated through firing tungsten carbide shells into the ground. Till the time of active experiments Mother Rover would act as a guiding unit to control spatial spread of detection instruments. After active shock experimentation, the babies can still act as passive seismometer units to study and record passive shocks from thermal quakes, impact cratering & landslides. Further other experiments / payloads (XPS / GAP / APXS) can also be carried by Mother Rover. Secondary power system consisting of batteries can also be utilized for carrying out further experiments over shallow valley surfaces. The whole arrangement is conceptually expected to increase the accuracy of measurements (through concurrent readings) and prolong life cycle of overall experimentation. The proposed rover can be customised according to the associated scientific objectives and further

  8. A multi-faceted approach of a nursing led education in response to MERS-CoV infection

    Jaffar A. Al-Tawfiq

    2018-03-01

    Full Text Available Background: The emergence of the Middle East respiratory syndrome-coronavirus (MERS-CoV resulted in multiple healthcare associated outbreaks. In response, we developed a nurse-led program to screen and triage patients with MERS-CoV infection. Methods: A formal educational program was implemented to ensure a standardized approach to care planning and delivery. The essential skills that were included were the use of Personal Protective Equipment (PPE including gown, gloves, head cover and N95 mask, hand hygiene, the practice of donning and doffing and the collection of MERS-CoV nasopharyngeal specimens. Results: A core group of nurses were identified from high-risk units. The education program consisted of four skill-days. Nurses were assigned a pre-course work from Mosby’s Nursing Skills, an online skill module, donning and doffing of PPE, and the process for obtaining a nasopharyngeal swab. The skill lab incorporated multiple methods such group discussion, watching an on-line video, and a simulated demonstration and practice on a mannequin. In total, 450 nurses attended the Nasopharyngeal Skills Day and 1000 nurses received training. Donning and doffing PPE and N95 mask fit testing has become an annual mandatory competency requirement for staff in nursing and clinical services. Conclusion: The application of specified protocols minimizes the risks of cross infection, placing emphasis on patient and staff safety as well as expediting the patient to definitive treatment. Nurse educators have an instrumental role in training nurses and other healthcare providers on the specifics needed to identify, contain and manage patient presenting with MERS-CoV. Keywords: Coronavirus, Education, MERS-CoV, Middle East respiratory syndrome, Saudi Arabia, Outbreak preparedness, Hospital care

  9. Pollution Prevention, Waste Minimization and Material Recycling Successes Realized during Savannah River Site's K Area Materials Storage (KAMS) Project, W226

    Ellis, M.S.

    2001-01-01

    As DOE continues to forge ahead and re-evaluate post cold war missions, facilities that were constructed and operated for DOE/DOD over the past 50+ years are coming to the end of their useful life span. These various facilities throughout the country had served a very useful purpose in our nations history; however, their time of Cold War materials production has come to an end. With this looming finalization comes a decision as to how to remedy their existence: D and R the facilities and return to ''Greenfield''; or, retrofit the existing facilities to accommodate the newer missions of the DOE Complex. The 105-K Reactor Building located at the Savannah River Site in Aiken, South Carolina was retrofit on an accelerated project schedule for a new mission called K-Area Materials Storage (KAMS). Modifications to the former defense reactor's building and equipment will allow storage of Plutonium from the Rocky Flats Site in Colorado and other materials deemed necessary by the Department of Energy. Proper project planning and activity sequencing allowed the DOE and the Westinghouse Savannah River Company to realize savings from: the recycling and/or reuse of modified facility components; reduction and reclassification of waste; reduction in radiological area footprint (rollbacks)

  10. Transcriptional switching by the MerR protein: Activation and repression mutants implicate distinct DNA and mercury(II) binding domains

    Shewchuk, L.M.; Helmann, J.D.; Ross, W.; Park, S.J.; Summers, A.O.; Walsh, C.T.

    1989-01-01

    Bacterial resistance to mercuric compounds is controlled by the MerR metalloregulatory protein. The MerR protein functions as both a transcriptional repressor and a mercuric ion dependent transcriptional activator. Chemical mutagenesis of the cloned merR structural gene has led to the identification of mutant proteins that are specifically deficient in transcriptional repression, activation, or both. Five mutant proteins have been overproduced, purified to homogeneity, and assayed for ability to dimerize, bind mer operator DNA, and bind mercuric ion. A mutation in the recognition helix of a proposed helix-turn-helix DNA binding motif (E22K) yields protein deficient in both activation and repression in vivo (a - r - ) and deficient in operator binding in vitro. In contrast, mutations in three of the four MerR cysteine residues are repression competent but activation deficient (a - r + ) in vivo. In vitro, the purified cysteine mutant proteins bind to the mer operator site with near wild-type affinity but are variable deficient in binding the in vivo inducer mercury(II) ion. A subset of the isolated proteins also appears compromised in their ability to form dimers at low protein concentrations. These data support a model in which DNA-bound MerR dimer binds one mercuric ion and transmits this occupancy information to a protein region involved in transcriptional activation

  11. Successful ageing

    Bülow, Morten Hillgaard; Söderqvist, Thomas

    2014-01-01

    Since the late 1980s, the concept of ‘ successful ageing’ has set the frame for discourse about contemporary ageing research. Through an analysis of the reception to John W. Rowe and Robert L. Kahn's launch of the concept of ‘ successful ageing’ in 1987, this article maps out the important themes...... and discussions that have emerged from the interdisciplinary field of ageing research. These include an emphasis on interdisciplinarity; the interaction between biology, psycho-social contexts and lifestyle choices; the experiences of elderly people; life-course perspectives; optimisation and prevention...... strategies; and the importance of individual, societal and scientific conceptualisations and understandings of ageing. By presenting an account of the recent historical uses, interpretations and critiques of the concept, the article unfolds the practical and normative complexities of ‘ successful ageing’....

  12. Citation Success

    Vaio, Gianfranco Di; Waldenström, Daniel; Weisdorf, Jacob Louis

    2012-01-01

    This study examines the determinants of citation success among authors who have recently published their work in economic history journals. Besides offering clues about how to improve one's scientific impact, our citation analysis also sheds light on the state of the field of economic history...... find similar patterns when assessing the same authors' citation success in economics journals. As a novel feature, we demonstrate that the diffusion of research — publication of working papers, as well as conference and workshop presentations — has a first-order positive impact on the citation rate........ Consistent with our expectations, we find that full professors, authors appointed at economics and history departments, and authors working in Anglo-Saxon and German countries are more likely to receive citations than other scholars. Long and co-authored articles are also a factor for citation success. We...

  13. The Peruvian Citizen Perception and Expectation toward the e-Government. The Electronic Tax Payment as a Successful e-Gov Project

    Diego Cardona

    2010-05-01

    Full Text Available In this chapter, the authors try to stand out how the Latin American governments, specifically the Peruvian government, can evaluate its efforts implementing electronic administration initiatives, identifying what the citizen expects from the electronic administration and how he or she perceives it, applying an evaluation model to the electronic tax payment service implemented, as a successful initiative at Latin-America. The proposed model to achieve this, was developed by one of the authors during his doctoral dissertation (Cardona, 2004 and evaluated by the other one as dissertation judge. It includes five different independent and latent constructs, Attitude, Aptitude, Trust, Relevance and Satisfaction that affect two dependent and latent constructs, the Citizen Perception and the Citizen Expectative towards its relationship with the Public Administration through the use of Information and Communication Technologies - ICT, under the effect of illustrative variables related with citizen, institutions and context.

  14. Successfully reducing newborn asphyxia in the labour unit in a large academic medical centre: a quality improvement project using statistical process control.

    Hollesen, Rikke von Benzon; Johansen, Rie Laurine Rosenthal; Rørbye, Christina; Munk, Louise; Barker, Pierre; Kjaerbye-Thygesen, Anette

    2018-02-03

    A safe delivery is part of a good start in life, and a continuous focus on preventing harm during delivery is crucial, even in settings with a good safety record. In January 2013, the labour unit at Copenhagen University Hospital, Hvidovre, undertook a quality improvement (QI) project to prevent asphyxia and reduced the percentage of newborns with asphyxia by 48%. The change theory consisted of two primary elements: (1) the clinical content, including three clinical bundles of evidence-based care, a 'delivery bundle', an 'oxytocin bundle' and a 'vacuum extraction bundle'; (2) an implementation theory, including improving skills in interpretation of cardiotocography, use of QI methods and participation in a national learning network. The Model for Improvement and Deming's system of profound knowledge were used as a methodological framework. Data on compliance with the care bundles and the number of deliveries between newborns with asphyxia (Apgar statistical process control. Compliance with all three clinical care bundles improved to 95% or more, and the percentages of newborns with pH <7 and Apgar <7 after 5 min were reduced by 48% and 31%, respectively. In general, the QI approach strengthened multidisciplinary teamwork, systematised workflow and structured communication around the deliveries. Changes included making a standard memo in the medical record, the use of a bedside whiteboard, bedside handovers, shared decisions with a peer when using an oxytocin infusion and the use of a checklist before vacuum extractions. This QI project illustrates how aspects of patient safety, such as the prevention of asphyxia, can be improved using QI methods to more reliably implement best practice, even in high-performing systems. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  15. Keys to a successful project: Associated data and planning: Data standards. Chapter 5 in Measuring and monitoring biological diversity: Standard methods for amphibians

    McDiarmid, Roy W.; Heyer, W. Ronald; Donnelly, Maureen A.; McDiarmid, Roy W.; Hayek, Lee-Ann C.; Foster, Mercedes S.

    1994-01-01

    The many individual salamanders, frogs, caecilians, and their larvae encountered during the course of an inventory or monitoring project will have to be identified to species. Depending on the goals and sampling method(s) used, some individuals will be identified from a distance by their calls, others will be handled. At the same time, some will be marked for recapture, and others will be sampled as vouchers. For each, certain minimum data should be recorded. In this section, data pertaining to locality and sampling methodology are considered, information on microhabitats and specimen vouchers is covered in sections that follow. I feel strongly that the data outlined here should be the minimum for any project. Investigators with specific goals may require additional types of data as well.Standardized, printed sheets containing the required data categories provide a convenient, inexpensive, and effective way to ensure that all the desired information is recorded in a consistent format, Data sheets should be well organized, printed on good-quality paper (75%-100% cotton content) and include extra space (e.g., other side of sheet) for notes that do not fit preestablished categoriesData should be recorded in the field with permanent (waterproof) ink as simply and directly as possible. I strongly recommend against the use of data codes in the field; it is too easy to forget codes or to enter the wrong code. Original data sheets can be photocopied for security, but they should not be copied by hand. If data are to be coded for computer analysis, the original or photocopied sheets should be used for data entry to minimize transcription errors. Some workers prefer recording information on small tape recorders; this also works well if a list of the standard data categories is checked during taping to ensure that all required information is recorded. Information recorded on tapes should be transcribed to data sheets or into a computer within 24 hours of the sample.

  16. Characterization of novel monoclonal antibodies against the MERS-coronavirus spike protein and their application in species-independent antibody detection by competitive ELISA.

    Fukushi, Shuetsu; Fukuma, Aiko; Kurosu, Takeshi; Watanabe, Shumpei; Shimojima, Masayuki; Shirato, Kazuya; Iwata-Yoshikawa, Naoko; Nagata, Noriyo; Ohnishi, Kazuo; Ato, Manabu; Melaku, Simenew Keskes; Sentsui, Hiroshi; Saijo, Masayuki

    2018-01-01

    Since discovering the Middle East respiratory syndrome coronavirus (MERS-CoV) as a causative agent of severe respiratory illness in the Middle East in 2012, serological testing has been conducted to assess antibody responses in patients and to investigate the zoonotic reservoir of the virus. Although the virus neutralization test is the gold standard assay for MERS diagnosis and for investigating the zoonotic reservoir, it uses live virus and so must be performed in high containment laboratories. Competitive ELISA (cELISA), in which a labeled monoclonal antibody (MAb) competes with test serum antibodies for target epitopes, may be a suitable alternative because it detects antibodies in a species-independent manner. In this study, novel MAbs against the spike protein of MERS-CoV were produced and characterized. One of these MAbs was used to develop a cELISA. The cELISA detected MERS-CoV-specific antibodies in sera from MERS-CoV-infected rats and rabbits immunized with the spike protein of MERS-CoV. The MAb-based cELISA was validated using sera from Ethiopian dromedary camels. Relative to the neutralization test, the cELISA detected MERS-CoV-specific antibodies in 66 Ethiopian dromedary camels with a sensitivity and specificity of 98% and 100%, respectively. The cELISA and neutralization test results correlated well (Pearson's correlation coefficients=0.71-0.76, depending on the cELISA serum dilution). This cELISA may be useful for MERS epidemiological investigations on MERS-CoV infection. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Tectonique dans la région de la mer de Beaufort (Arctique canadien (résumé Tectonism in the Beaufort Sea - Region of Arctic Canada (Abstract

    Mroszczak W. E.

    2006-10-01

    Full Text Available Le delta de la Mackenzie et la mer de Beaufort qui en sont encore au début de l'exploration, peuvent devenir une région pétrolière majeure dans les années 1980. Ce vaste bassin tertiaire est situé dans un environnement arctique ; il a demandé et nécessitera dans l'avenir de nouvelles technologies pour développer et produire les hydrocarbures si l'exploration est couronnée de succès. L'exploration pour l'huile et le gaz a été active dans cette région depuis 1965 bien que les facteurs climatiques et économiques aient eu tendance à freiner cette exploration, particulièrement en mer. L'auteur présente un bref historique des recherches comprenant les derniers résultats des sondage dans la mer de Beaufort forés par Dome Petroleum et ses partenaires. On discute aussi l'origine des structures en mer, en commentant les données sismiques. La structuration est considérée comme le résultat d'une sédimentation rapide de clastiques au Tertiaire dans un bassin dont le substratum serait formé d'une épaisse série d'argiles sous-compactées d'âge jurassique ou crétacé. The Mackenzie Delta and offshore Beaufort Sea Region which is at a very early stage of exploration, may become a major source of hydrocarbons in the 1980's This large Tertiary basin is situated in an Arctic environment and has required, and will require in the future, new technology to develop and produce hydrocarbons if exploration is successful. Exploration for oil and gas has been active in the area since 1965 with climatic and economic factors contributing ta a slow pace of exploration, particularly in the offshore area. A brief history of exploration with and update of the latest results of drilling in the Beaufort by Dome Petroleum and its partners is presented. Using seismic data, the genesis of structures found in the offshore area is discussed. These are believed to be the result of rapid Tertiary clastic deposition in a basin underlain by a thick section of

  18. Citation Success

    Di Vaio, Gianfranco; Waldenström, Daniel; Weisdorf, Jacob Louis

    affects citations. In regard to author-specific characteristics, male authors, full professors and authors working economics or history departments, and authors employed in Anglo-Saxon countries, are more likely to get cited than others. As a ‘shortcut' to citation success, we find that research diffusion...

  19. Successful modeling?

    Lomnitz, Cinna

    Tichelaar and Ruff [1989] propose to “estimate model variance in complicated geophysical problems,” including the determination of focal depth in earthquakes, by means of unconventional statistical methods such as bootstrapping. They are successful insofar as they are able to duplicate the results from more conventional procedures.

  20. Successful ageing

    Kusumastuti, Sasmita; Derks, Marloes G. M.; Tellier, Siri

    2016-01-01

    BACKGROUND: Ageing is accompanied by an increased risk of disease and a loss of functioning on several bodily and mental domains and some argue that maintaining health and functioning is essential for a successful old age. Paradoxically, studies have shown that overall wellbeing follows a curvili...