FIXING HEALTH SYSTEMS / Executive Summary (2008 update ...

International Development Research Centre (IDRC) Digital Library (Canada)

2010-12-14

Dec 14, 2010 ... FIXING HEALTH SYSTEMS / Executive Summary (2008 update) ... In several cases, specific approaches recommended by the TEHIP team have been acted upon regionally and internationally, including the ... Related articles ...

Particulate matter emissions of different brands of mentholated cigarettes.

Science.gov (United States)

Gerharz, Julia; Bendels, Michael H K; Braun, Markus; Klingelhöfer, Doris; Groneberg, David A; Mueller, Ruth

2018-01-09

Inhaling particulate matter (PM) in environmental tobacco smoke (ETS) endangers the health of nonsmokers. Menthol, an additive in cigarettes, attenuates respiratory irritation of tobacco smoke. It reduces perceptibility of smoke and therefore passive smokers may inhale ETS unnoticed. To investigate a possible effect of menthol on PM concentrations (PM 10 , PM 2.5 , and PM 1 ), ETS of four mentholated cigarette brands (Elixyr Menthol, Winston Menthol, Reyno Classic, and Pall Mall Menthol Blast) with varying menthol content was analyzed. ETS was generated in a standardized way using an automatic environmental tobacco smoke emitter (AETSE), followed by laser aerosol spectrometry. This analysis shows that the tested cigarette brands, despite having different menthol concentrations, do not show differences with regard to PM emissions, with the exception of Reyno Classic, which shows an increased emission, although the menthol level ranged in the midfield. More than 90% of the emitted particles had a size smaller than or equal to 1 µm. Regardless of the menthol level, the count median diameter (CMD) and the mass median diameter (MMD) were found to be 0.3 µm and 0.5 µm, respectively. These results point out that there is no effect of menthol on PM emission and that other additives might influence the increased PM emission of Reyno Classic. Particulate matter (PM) in ETS endangers the health of nonsmokers and smokers. This study considers the effect of menthol, an additive in cigarettes, on PM emissions. Does menthol increase the amount of PM? Due to the exposure to secondhand smoke nearly 900,000 people die each year worldwide. The aim of the study is to measure the particle concentration (L -1 ), mass concentration (µg m -3 ), and dust mass fractions shown as PM 10 , PM 2.5 , and PM 1 of five different cigarette brands, including four with different menthol concentrations and one menthol-free reference cigarette, in a well-established standardized system.

Menthol cigarettes and smoking initiation: a tobacco industry perspective.

Science.gov (United States)

Klausner, Kim

2011-05-01

To determine what the tobacco industry knew about menthol cigarettes and the initiation of smoking. Based on Food and Drug Administration staff-supplied research questions we used a snowball sampling strategy to search the Legacy Tobacco Documents Library (http://legacy.library.ucsf.edu) between February and April 2010. Of the approximately 11 million documents available in the LTDL, the iterative searches returned tens of thousands of results. Researchers reviewed 2634 documents and 128 were deemed relevant to one or more of the research questions. The documents show that menthol is added to cigarettes in part because it is known to be an attractive feature to inexperienced smokers who perceive menthol cigarettes as less harsh and easier to smoke and because of their availability from friends and family. Second, the tobacco industry found that some youths smoke menthols because they perceive them to be less harmful than non-menthol cigarettes. A key product design issue concerns whether to increase brand menthol levels to appeal to the taste preferences of long-term menthol smokers or keep menthol levels lower to appeal to inexperienced smokers. Marketing studies showed that the companies carefully researched the menthol segment of the market in order to recruit younger smokers to their brands. The industry tracked menthol cigarette usage by age, gender and race to inform product development and marketing decisions. Menthol is a prominent design feature used by cigarette manufacturers to attract and retain new, younger smokers.

Know More About Menthol Cigarettes

Science.gov (United States)

... to Quit Why Do You Want to Quit? Health Effects Benefits of Quitting How Much Will You Save How Smoking Affects Your Workout Secondhand Smoke Quiz: How Bad is Secondhand Smoke? E-Cigs, Menthol & Dip What We Know About E-Cigarettes Know More About Menthol Cigarettes Quitting Dip Stay ...

Menthol Cigarettes, Time to First Cigarette, and Smoking Cessation

Directory of Open Access Journals (Sweden)

Sanders Edward

2017-01-01

Full Text Available The goal of the present work is to determine if menthol and non-menthol cigarette smokers differ with respect to time to first cigarette (TTFC and successful smoking cessation via a meta-analysis of published results. For 13 independent estimates, menthol smokers were slightly but statistically significantly more likely to exhibit TTFC ≤ 5 min (random-effects odds ratio (OR = 1.12; 95% confidence interval (CI, 1.04–1.21, while 17 independent estimates provided a non-significant difference for TTFC ≤ 30 min (random-effects OR = 1.06; 95% CI, 0.96–1.16. For cessation studies, meta-analysis of 30 published estimates indicated a decreased likelihood for menthol cigarette smokers to quit (random-effects OR = 0.87; 95% CI, 0.80–0.96. There was no difference between cessation rates for Caucasian menthol and non-menthol cigarette smokers, but the results support that African American menthol cigarette smokers find it more difficult to quit. Adjustment of cessation for socioeconomic status eliminated any statistically significant advantage for smoking cessation in non-menthol smokers. In conclusion, these results suggest that the observed differences in cessation rates between menthol and non-menthol cigarette smokers are likely explained by differences in socioeconomic status and also suggest that TTFC may not be a robust predictor of successful smoking cessation.

Current State of Dental Education: Executive Summary.

Science.gov (United States)

Formicola, Allan J

2017-08-01

This executive summary for Section 1 of the "Advancing Dental Education in the 21 st Century" project provides a composite picture of information from 12 background articles on the current state of dental education in the United States. The summary includes the following topics: the current status of the dental curriculum, the implications of student debt and dental school finances, the expansion of enrollment, student diversity, pre- and postdoctoral education, safety net status of dental school clinics, and trends in faculty.

Menthol binding and inhibition of α7-nicotinic acetylcholine receptors.

Directory of Open Access Journals (Sweden)

Abrar Ashoor

Full Text Available Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes. The molecular targets of menthol remain poorly defined. In this study we show an effect of menthol on the α7 subunit of the nicotinic acetylcholine (nACh receptor function. Using a two-electrode voltage-clamp technique, menthol was found to reversibly inhibit α7-nACh receptors heterologously expressed in Xenopus oocytes. Inhibition by menthol was not dependent on the membrane potential and did not involve endogenous Ca(2+-dependent Cl(- channels, since menthol inhibition remained unchanged by intracellular injection of the Ca(2+ chelator BAPTA and perfusion with Ca(2+-free bathing solution containing Ba(2+. Furthermore, increasing ACh concentrations did not reverse menthol inhibition and the specific binding of [(125I] α-bungarotoxin was not attenuated by menthol. Studies of α7- nACh receptors endogenously expressed in neural cells demonstrate that menthol attenuates α7 mediated Ca(2+ transients in the cell body and neurite. In conclusion, our results suggest that menthol inhibits α7-nACh receptors in a noncompetitive manner.

Differential trends in cigarette smoking in the USA: is menthol slowing progress?

Science.gov (United States)

Giovino, Gary A; Villanti, Andrea C; Mowery, Paul D; Sevilimedu, Varadan; Niaura, Raymond S; Vallone, Donna M; Abrams, David B

2015-01-01

Mentholated cigarettes are at least as dangerous to an individual's health as non-mentholated varieties. The addition of menthol to cigarettes reduces perceived harshness of smoke, which can facilitate initiation. Here, we examine correlates of menthol use, national trends in smoking menthol and non-menthol cigarettes, and brand preferences over time. We estimated menthol cigarette use during 2004-2010 using annual data on persons ≥12 years old from the National Surveys on Drug Use and Health. We adjusted self-reported menthol status for selected brands that were either exclusively menthol or non-menthol, based on sales data. Data were weighted to provide national estimates. Among cigarette smokers, menthol cigarette use was more common among 12-17 year olds (56.7%) and 18-25 year olds (45.0%) than among older persons (range 30.5% to 34.7%). In a multivariable analysis, menthol use was associated with being younger, female and of non-Caucasian race/ethnicity. Among all adolescents, the percentage who smoked non-menthol cigarettes decreased from 2004-2010, while menthol smoking rates remained constant; among all young adults, the percentage who smoked non-menthol cigarettes also declined, while menthol smoking rates increased. The use of Camel menthol and Marlboro menthol increased among adolescent and young adult smokers, particularly non-Hispanic Caucasians, during the study period. Young people are heavy consumers of mentholated cigarettes. Progress in reducing youth smoking has likely been attenuated by the sale and marketing of mentholated cigarettes, including emerging varieties of established youth brands. This study should inform the Food and Drug Administration regarding the potential public health impact of a menthol ban. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

NanoByg - a survey of nanoinnovation in Danish construction. Executive summary, dansk

DEFF Research Database (Denmark)

Andersen, Maj Munch; Molin, Måns J.

Denne tekst er et Executive summary af Risø rapporten, ''NanoByg - A survey of nanoinnovation in Danish construction''. (Risø-R-1602 (EN), 72 p.)......Denne tekst er et Executive summary af Risø rapporten, ''NanoByg - A survey of nanoinnovation in Danish construction''. (Risø-R-1602 (EN), 72 p.)...

Menthol cigarettes and the public health standard: a systematic review.

Science.gov (United States)

Villanti, Andrea C; Collins, Lauren K; Niaura, Raymond S; Gagosian, Stacey Y; Abrams, David B

2017-12-29

Although menthol was not banned under the Tobacco Control Act, the law made it clear that this did not prevent the Food and Drug Administration from issuing a product standard to ban menthol to protect public health. The purpose of this review was to update the evidence synthesis regarding the role of menthol in initiation, dependence and cessation. A systematic review of the peer-reviewed literature on menthol cigarettes via a PubMed search through May 9, 2017. The National Cancer Institute's Bibliography of Literature on Menthol and Tobacco and the FDA's 2011 report and 2013 addendum were reviewed for additional publications. Included articles addressing initiation, dependence, and cessation were synthesized based on study design and quality, consistency of evidence across populations and over time, coherence of findings across studies, and plausibility of the findings. Eighty-two studies on menthol cigarette initiation (n = 46), dependence (n = 14), and cessation (n = 34) were included. Large, representative studies show an association between menthol and youth smoking that is consistent in magnitude and direction. One longitudinal and eight cross-sectional studies demonstrate that menthol smokers report increased nicotine dependence compared to non-menthol smokers. Ten studies support the temporal relationship between menthol and reduced smoking cessation, as they measure cessation success at follow-up. The strength and consistency of the associations in these studies support that the removal of menthol from cigarettes is likely to reduce youth smoking initiation, improve smoking cessation outcomes in adult smokers, and in turn, benefit public health.

Executive Summary, Hydraulic Fracturing Study - Draft Assessment 2015

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In this Executive Summary of the HF Draft report, EPA highlights the reviews of scientific literature to assess the potential for hydraulic fracturing for oil and gas to change the quality or quantity of drinking water resources.

Model Adoption Exchange Payment System: Executive Summary.

Science.gov (United States)

Ambrosino, Robert J.

This executive summary provides a brief description of the Model Adoption Exchange Payment System (MAEPS), a unique payment system aimed at improving the delivery of adoption exchange services throughout the United States. Following a brief introductory overview, MAEPS is described in terms of (1) its six components (registration, listing,…

Adolescent menthol smokers: will they be a harder target for cessation?

Science.gov (United States)

Moolchan, Eric T

2004-02-01

Menthol smoking may influence the development of tobacco addiction and related health consequences, yet limited data on menthol smoking by youth are available. We assessed usual brand menthol preference by Baltimore-area teenage smokers applying to a smoking cessation study between September 1999 and December 2002. Of a biethnic (Black and White) sample of 593 youths (mean age=15.5+/-1.4 years, 51% female, 45% African American), the overwhelming majority (93%) were menthol smokers. Menthol preference rates were highest among African American girls and lowest among White boys. Overall, a statistically significant association was found between ethnicity and menthol preference, chi2 (df=1)=19.4, page in either ethnic group. These findings of overwhelming menthol preference in a treatment-seeking sample of adolescents warrant further research on the developmental trajectory, cessation, and health-related impact of menthol smoking by youth.

Menthol cigarette smoking and obesity in young adult daily smokers in Hawaii

Directory of Open Access Journals (Sweden)

Alyssa Marie M. Antonio

2015-01-01

Full Text Available This study investigates 1 the relationship between menthol cigarette smoking and obesity and 2 the association of body mass index with the nicotine metabolite ratio among menthol and non-menthol daily smokers aged 18–35 (n = 175. A brief survey on smoking and measures of height and weight, carbon monoxide, and saliva samples were collected from participants from May to December 2013 in Honolulu, Hawaii. Multiple regression was used to estimate differences in body mass index among menthol and non-menthol smokers and the association of menthol smoking with obesity. We calculated the log of the nicotine metabolite ratio to examine differences in the nicotine metabolite ratio among normal, overweight, and obese smokers. Sixty-eight percent of smokers used menthol cigarettes. Results showed that 62% of normal, 54% of overweight, and 91% of obese smokers used menthol cigarettes (p = .000. The mean body mass index was significantly higher among menthol compared with non-menthol smokers (29.4 versus 24.5, p = .000. After controlling for gender, marital status, educational attainment, employment status, and race/ethnicity, menthol smokers were more than 3 times as likely as non-menthol smokers to be obese (p = .04. The nicotine metabolite ratio was significantly lower for overweight menthol smokers compared with non-menthol smokers (.16 versus .26, p = .02 in the unadjusted model, but was not significant after adjusting for the covariates. Consistent with prior studies, our data show that menthol smokers are more likely to be obese compared with non-menthol smokers. Future studies are needed to determine how flavored tobacco products influence obesity among smokers.

Menthol Cigarette Smoking among Lesbian, Gay, Bisexual, and Transgender Adults

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Fallin, Amanda; Goodin, Amie J.; King, Brian A.

2015-01-01

Background Menthol can mask the harshness and taste of tobacco, making menthol cigarettes easier to use and increasing their appeal among vulnerable populations. The tobacco industry has targeted youth, women, and racial minorities with menthol cigarettes, and these groups smoke menthol cigarettes at higher rates. The tobacco industry has also targeted the lesbian, gay, bisexual, and transgender (LGBT) communities with tobacco product marketing. Purpose To assess current menthol cigarette smoking by sexual orientation among a nationally representative sample of U.S. adults. Methods Data were obtained from the 2009–2010 National Adult Tobacco Survey, a national landline and cellular telephone survey of non-institutionalized U.S. adults aged ≥18 years, to compare current menthol cigarette smoking between LGBT (n=2,431) and heterosexual/straight (n=110,841) adults. Data were analyzed during January–April 2014 using descriptive statistics and logistic regression adjusted for sex, age, race, and educational attainment. Results Among all current cigarette smokers, 29.6% reported usually smoking menthol cigarettes in the past 30 days. Menthol use was significantly higher among LGBT smokers, with 36.3% reporting that the cigarettes they usually smoked were menthol compared to 29.3% of heterosexual/straight smokers (p<0.05); this difference was particularly prominent among LGBT females (42.9%) compared to heterosexual/straight women (32.4%) (p<0.05). Following adjustment, LGBT smokers had greater odds of usually smoking menthol cigarettes than heterosexual/straight smokers (OR=1.31, 95% CI=1.09, 1.57). Conclusions These findings suggest that efforts to reduce menthol cigarette use may have the potential to reduce tobacco use and tobacco-related disease and death among LGBT adults. PMID:25245795

NanoByg - a survey of nanoinnovation in Danish construction. Executive summary in English

DEFF Research Database (Denmark)

Andersen, Maj Munch; Molin, Måns J.

This is an executive summary of the Risoe report, Risø-R-1602 (EN), with the title ''NanoByg - A survey of nanoinnovation in Danish construction''.......This is an executive summary of the Risoe report, Risø-R-1602 (EN), with the title ''NanoByg - A survey of nanoinnovation in Danish construction''....

TFOS DEWS II Report Executive Summary.

Science.gov (United States)

Craig, Jennifer P; Nelson, J Daniel; Azar, Dimitri T; Belmonte, Carlos; Bron, Anthony J; Chauhan, Sunil K; de Paiva, Cintia S; Gomes, José A P; Hammitt, Katherine M; Jones, Lyndon; Nichols, Jason J; Nichols, Kelly K; Novack, Gary D; Stapleton, Fiona J; Willcox, Mark D P; Wolffsohn, James S; Sullivan, David A

2017-10-01

This article presents an Executive Summary of the conclusions and recommendations of the 10-chapter TFOS DEWS II report. The entire TFOS DEWS II report was published in the July 2017 issue of The Ocular Surface. A downloadable version of the document and additional material, including videos of diagnostic and management techniques, are available on the TFOS website: www.TearFilm.org. Copyright © 2017 Elsevier Inc. All rights reserved.

Inflammatory Effects of Menthol vs. Non-menthol Cigarette Smoke Extract on Human Lung Epithelial Cells: A Double-Hit on TRPM8 by Reactive Oxygen Species and Menthol

Directory of Open Access Journals (Sweden)

Tzong-Shyuan Lee

2017-04-01

Full Text Available Clinical studies suggest that smokers with chronic obstructive pulmonary disease who use menthol cigarettes may display more severe lung inflammation than those who smoke non-menthol cigarette. However, the mechanisms for this difference remain unclear. Menthol is a ligand of transient receptor potential melastatin-8 (TRPM8, a Ca2+-permeant channel sensitive to reactive oxygen species (ROS. We previously reported that exposure of human bronchial epithelial cells (HBECs to non-menthol cigarette smoke extract (Non-M-CSE triggers a cascade of inflammatory signaling leading to IL-8 induction. In this study, we used this in vitro model to compare the inflammatory effects of menthol cigarette smoke extract (M-CSE and Non-M-CSE and delineate the mechanisms underlying the differences in their impacts. Compared with Non-M-CSE, M-CSE initially increased a similar level of extracellular ROS, suggesting the equivalent oxidant potency. However, M-CSE subsequently produced more remarkable elevations in intracellular Ca2+, activation of the mitogen-activated protein kinases (MAPKs/nuclear factor-κB (NF-κB signaling, and IL-8 induction. The extracellular ROS responses to both CSE types were totally inhibited by N-acetyl-cysteine (NAC; a ROS scavenger. The intracellular Ca2+ responses to both CSE types were also totally prevented by NAC, AMTB (a TRPM8 antagonist, or EGTA (an extracellular Ca2+ chelator. The activation of the MAPK/NF-κB signaling and induction of IL-8 to both CSE types were suppressed to similar levels by NAC, AMTB, or EGTA. These results suggest that, in addition to ROS generated by both CSE types, the menthol in M-CSE may act as another stimulus to further activate TRPM8 and induce the observed responses. We also found that menthol combined with Non-M-CSE induced greater responses of intracellular Ca2+ and IL-8 compared with Non-M-CSE alone. Moreover, we confirmed the essential role of TRPM8 in these responses to Non-M-CSE or M-CSE and the

Sensory Effects of Menthol and Nicotine in an E-Cigarette.

Science.gov (United States)

Rosbrook, Kathryn; Green, Barry G

2016-07-01

Despite the longstanding use and popularity of menthol as a flavorant in tobacco products, its sensory interactions with inhaled nicotine have never been measured independently of the other irritants in tobacco smoke. We therefore measured the perception of menthol in an E-cigarette with the primary goal of assessing its analgesic effect on the sensory irritation produced by inhaled nicotine. Adult cigarette smokers sampled aerosolized E-liquids containing five different concentrations of nicotine with 0%, 0.5%, or 3.5% l-menthol, as well as two commercial menthol flavors with and without nicotine. For each of the E-liquids participants used a labeled magnitude scale to rate the Overall Sensation intensity, Coolness/Cold, and Irritation/Harshness they experienced, and a Labeled Hedonic Scale to indicate how much they liked/disliked the overall flavor. The main findings were that (1) perceived Irritation/Harshness was unaffected by a low (0.5%) menthol concentration, whereas a high menthol concentration (3.5%) led to higher perceived Irritation/Harshness at low nicotine concentrations but to lower Irritation/Harshness at the highest nicotine concentration (24mg/ml); (2) a commercial Menthol-Mint flavor produced similar results; (3) nicotine tended to enhance rather than suppress sensations of Coolness/Cold; and (4) menthol tended to slightly increase liking independently of nicotine concentration. In addition to adding a sensation of coolness, menthol can reduce perceived airway irritation and harshness produced by inhalation when nicotine concentration is high, and contributes to the sensory impact of E-liquids when nicotine concentration is low. The evidence presented here indicates that menthol can potentially improve the appeal of E-cigarettes not only via its coolness and minty flavor, but also by reducing the harshness from high concentrations of nicotine. As the first direct demonstration of an analgesic effect of menthol on inhaled nicotine in humans, these

Perceptions of Menthol Cigarettes Among Twitter Users: Content and Sentiment Analysis.

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Rose, Shyanika W; Jo, Catherine L; Binns, Steven; Buenger, Melissa; Emery, Sherry; Ribisl, Kurt M

2017-02-27

Menthol cigarettes are used disproportionately by African American, female, and adolescent smokers. Twitter is also used disproportionately by minority and younger populations, providing a unique window into conversations reflecting social norms, behavioral intentions, and sentiment toward menthol cigarettes. Our purpose was to identify the content and frequency of conversations about menthol cigarettes, including themes, populations, user smoking status, other tobacco or substances, tweet characteristics, and sentiment. We also examined differences in menthol cigarette sentiment by prevalent categories, which allowed us to assess potential perceptions, misperceptions, and social norms about menthol cigarettes on Twitter. This approach can inform communication about these products, particularly to subgroups who are at risk for menthol cigarette use. Through a combination of human and machine classification, we identified 94,627 menthol cigarette-relevant tweets from February 1, 2012 to January 31, 2013 (1 year) from over 47 million tobacco-related messages gathered prospectively from the Twitter Firehose of all public tweets and metadata. Then, 4 human coders evaluated a random sample of 7000 tweets for categories, including sentiment toward menthol cigarettes. We found that 47.98% (3194/6657) of tweets expressed positive sentiment, while 40.26% (2680/6657) were negative toward menthol cigarettes. The majority of tweets by likely smokers (2653/4038, 65.70%) expressed positive sentiment, while 91.2% (320/351) of nonsmokers and 71.7% (91/127) of former smokers indicated negative views. Positive views toward menthol cigarettes were predominant in tweets that discussed addiction or craving, marijuana, smoking, taste or sensation, song lyrics, and tobacco industry or marketing or tweets that were commercial in nature. Negative views toward menthol were more common in tweets about smoking cessation, health, African Americans, women, and children and adolescents

Hawaii energy strategy: Executive summary, October 1995

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-10-01

This is an executive summary to a report on the Hawaii Energy Strategy Program. The topics of the report include the a description of the program including an overview, objectives, policy statement and purpose and objectives; energy strategy policy development; energy strategy projects; current energy situation; modeling Hawaii`s energy future; energy forecasts; reducing energy demand; scenario assessment, and recommendations.

Slowing Menthol's Progress: Differential Impact of a Tobacco Tax Increase on Cigarette Sales.

Science.gov (United States)

Amato, Michael S; D'Silva, Joanne; Boyle, Raymond G

2016-05-01

The proportion of smokers who use menthol cigarettes has increased nationally since 2004, while use of non-menthol cigarettes is declining, suggesting that menthol may be undermining the effectiveness of population level tobacco control efforts. In 2013 Minnesota passed a $1.75 cigarette tax increase. We investigated whether sales of menthol and non-menthol cigarettes were differentially affected by the price increase. Cigarette sales data from convenience stores in the Minneapolis, Minnesota, metro area from January 2012, through May 2015, were obtained. Proportion of sales accounted for by menthol cigarettes was analyzed with segmented regression. Before the price increase, menthol cigarettes gained 2.21% (1.17, 3.12) of market share annually. Following the price increase, the trend slowed to 0.26% (-0.78, 1.56) annually. The slope before the price increase was significantly positive; the slope following the price increase did not significantly differ from zero. Sales of menthol cigarettes declined less rapidly than non-menthol cigarettes before the price increase. Sales of menthol and non-menthol cigarettes declined at more comparable rates after the price increase. Increasing the price of tobacco may help ensure declines in consumption are more evenly distributed across menthol and non-menthol cigarettes. Using sales data, we found that a trend of increasing market share for menthol cigarettes was significantly reduced by a $1.75 cigarette price increase. These results suggest that cigarette price increases, a core tobacco control policy, may have a greater effect on menthol smokers than non-menthol smokers. © The Author 2015. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Evaluation of Potential Effect of Menthol Solution on Oral Hygiene ...

African Journals Online (AJOL)

Purpose: To test the effect of menthol extract on the oral hygiene status of dental students of Faculty of Dentistry, Al- Mustansiriya University, Baghdad, Iraq. Methods: A solution (18 mg %) of menthol was prepared by dissolving menthol crystals in absolute ethanol. Chlorhexidine (CHX, 0.2 %) and deionized water were used ...

Electrospinning of functional poly(methyl methacrylate) nanofibers containing cyclodextrin-menthol inclusion complexes

Energy Technology Data Exchange (ETDEWEB)

Uyar, Tamer; Besenbacher, Flemming [Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000, Aarhus C (Denmark); Nur, Yusuf; Hacaloglu, Jale [Department of Chemistry, Middle East Technical University, Ankara, 06530 (Turkey)], E-mail: tamer@inano.dk, E-mail: tamer@unam.bilkent.edu.tr

2009-03-25

Electrospinning of nanofibers with cyclodextrin inclusion complexes (CD-ICs) is particularly attractive since distinct properties can be obtained by combining the nanofibers with specific functions of the CD-ICs. Here we report on the electrospinning of poly(methyl methacrylate) (PMMA) nanofibers containing cyclodextrin-menthol inclusion complexes (CD-menthol-ICs). These CD-menthol-IC functionalized nanofibers were developed with the purpose of producing functional nanofibers that contain fragrances/flavors with high temperature stability, and menthol was used as a model fragrance/flavor material. The PMMA nanofibers were electrospun with CD-menthol-ICs using three type of CD: {alpha}-CD, {beta}-CD, and {gamma}-CD. Direct pyrolysis mass spectrometry (DP-MS) studies showed that the thermal evaporation of menthol occurred over a very high and a broad temperature range (100-355 deg. C) for PMMA/CDmenthol-IC nanowebs, demonstrating the complexation of menthol with the CD cavity and its high temperature stability. Furthermore, as the size of CD cavity increased in the order {alpha}-CD<{beta}-CD<{gamma}-CD, the thermal evolution of menthol shifted to higher temperatures, suggesting that the strength of interaction between menthol and the CD cavity is in the order {gamma}-CD>{beta}-CD>{alpha}-CD.

FWP executive summaries: Basic energy sciences materials sciences programs

Energy Technology Data Exchange (ETDEWEB)

Samara, G.A.

1996-02-01

This report provides an Executive Summary of the various elements of the Materials Sciences Program which is funded by the Division of Materials Sciences, Office of Basic Energy Sciences, U.S. Department of Energy at Sandia National Laboratories, New Mexico.

Menthol attenuates respiratory irritation and elevates blood cotinine in cigarette smoke exposed mice.

Directory of Open Access Journals (Sweden)

Michael A Ha

Full Text Available Addition of menthol to cigarettes may be associated with increased initiation of smoking. The potential mechanisms underlying this association are not known. Menthol, likely due to its effects on cold-sensing peripheral sensory neurons, is known to inhibit the sensation of irritation elicited by respiratory irritants. However, it remains unclear whether menthol modulates cigarette smoke irritancy and nicotine absorption during initial exposures to cigarettes, thereby facilitating smoking initiation. Using plethysmography in a C57Bl/6J mouse model, we examined the effects of L-menthol, the menthol isomer added to cigarettes, on the respiratory sensory irritation response to primary smoke irritants (acrolein and cyclohexanone and smoke of Kentucky reference 2R4 cigarettes. We also studied L-menthol's effect on blood levels of the nicotine metabolite, cotinine, immediately after exposure to cigarette smoke. L-menthol suppressed the irritation response to acrolein with an apparent IC₅₀ of 4 ppm. Suppression was observed even at acrolein levels well above those necessary to produce a maximal response. Cigarette smoke, at exposure levels of 10 mg/m³ or higher, caused an immediate and marked sensory irritation response in mice. This response was significantly suppressed by L-menthol even at smoke concentrations as high as 300 mg/m³. Counterirritation by L-menthol was abolished by treatment with a selective inhibitor of Transient Receptor Potential Melastatin 8 (TRPM8, the neuronal cold/menthol receptor. Inclusion of menthol in the cigarette smoke resulted in roughly a 1.5-fold increase in plasma cotinine levels over those observed in mice exposed to smoke without added menthol. These findings document that, L-menthol, through TRPM8, is a strong suppressor of respiratory irritation responses, even during highly noxious exposures to cigarette smoke or smoke irritants, and increases blood cotinine. Therefore, L-menthol, as a cigarette additive, may

Marketing of menthol cigarettes and consumer perceptions: a review of tobacco industry documents.

Science.gov (United States)

Anderson, Stacey J

2011-05-01

To examine tobacco industry marketing of menthol cigarettes and to determine what the tobacco industry knew about consumer perceptions of menthol. A snowball sampling design was used to systematically search the Legacy Tobacco Documents Library (LTDL) (http://legacy.library.ucsf.edu) between 28 February and 27 April 2010. Of the approximately 11 million documents available in the LTDL, the iterative searches returned tens of thousands of results from the major US tobacco companies and affiliated organisations. A collection of 953 documents from the 1930s to the first decade of the 21st century relevant to 1 or more of the research questions were qualitatively analysed, as follows: (1) are/were menthol cigarettes marketed with health reassurance messages? (2) What other messages come from menthol cigarette advertising? (3) How do smokers view menthol cigarettes? (4) Were menthol cigarettes marketed to specific populations? Menthol cigarettes were marketed as, and are perceived by consumers to be, healthier than non-menthol cigarettes. Menthol cigarettes are also marketed to specific social and demographic groups, including African-Americans, young people and women, and are perceived by consumers to signal social group belonging. The tobacco industry knew consumers perceived menthol as healthier than non-menthol cigarettes, and this was the intent behind marketing. Marketing emphasising menthol attracts consumers who may not otherwise progress to regular smoking, including young, inexperienced users and those who find 'regular' cigarettes undesirable. Such marketing may also appeal to health-concerned smokers who might otherwise quit.

Compendium of Executive Summaries from the Maglev System Concept Definition. Final Reports.

Science.gov (United States)

1993-03-01

This report contains the Executive Summaries from the four System Concept Definition (SCD) studies awarded under the National Maglev Initiative...These summaries present the technical feasibility, performance, capital, operating and maintenance costs for a maglev system that would be available by

Executive Summary: Forests of the Northern United States

Science.gov (United States)

Stephen R. Shifley; Francisco X. Aguilar; Nianfu Song; Susan I. Stewart; David J. Nowak; Dale D. Gormanson; W. Keith Moser; Sherri Wormstead; Eric J. Greenfield

2012-01-01

This executive summary provides an overview of the 200-page report, Forests of the Northern United States, which covers in detail current forest conditions, recent trends, issues, threats and opportunities in the forests in the 20 Northern States. It provides a context for subsequent Northern Forest Futures Project analyses that will forecast alternative future...

TRPM8 mediates cold and menthol allergies associated with mast cell activation.

Science.gov (United States)

Cho, Yeongyo; Jang, Yongwoo; Yang, Young Duk; Lee, Chang-Hun; Lee, Yunjong; Oh, Uhtaek

2010-10-01

Exposure to low temperatures often causes allergic responses or urticaria. Similarly, menthol, a common food additive is also known to cause urticaria, asthma, and rhinitis. However, despite the obvious clinical implications, the molecular mechanisms responsible for inducing allergic responses to low temperatures and menthol have not been determined. Because a non-selective cation channel, transient receptor potential subtype M8 (TRPM8) is activated by cold and menthol, we hypothesized that this channel mediates cold- and menthol-induced histamine release in mast cells. Here, we report that TRPM8 is expressed in the basophilic leukemia mast cell line, RBL-2H3, and that exposure to menthol or low temperatures induced Ca(2+) influx in RBL-2H3 cells, which was reversed by a TRPM8 blocker. Furthermore, menthol, a TRPM8 agonist, induced the dose-dependent release of histamine from RBL-2H3 cells. When TRPM8 transcripts were reduced by siRNA (small interfering RNA), menthol- and cold-induced Ca(2+) influx and histamine release were significantly reduced. In addition, subcutaneous injection of menthol evoked scratching, a typical histamine-induced response which was reversed by a TRPM8 blocker. Thus, our findings indicate that TRPM8 mediates the menthol- and cold-induced allergic responses of mast cells, and suggest that TRPM8 antagonists be viewed as potential treatments for cold- and menthol-induced allergies. Copyright © 2010 Elsevier Ltd. All rights reserved.

Electrospinning of functional poly(methyl methacrylate) nanofibers containing cyclodextrin-menthol inclusion complexes

International Nuclear Information System (INIS)

Uyar, Tamer; Besenbacher, Flemming; Nur, Yusuf; Hacaloglu, Jale

2009-01-01

Electrospinning of nanofibers with cyclodextrin inclusion complexes (CD-ICs) is particularly attractive since distinct properties can be obtained by combining the nanofibers with specific functions of the CD-ICs. Here we report on the electrospinning of poly(methyl methacrylate) (PMMA) nanofibers containing cyclodextrin-menthol inclusion complexes (CD-menthol-ICs). These CD-menthol-IC functionalized nanofibers were developed with the purpose of producing functional nanofibers that contain fragrances/flavors with high temperature stability, and menthol was used as a model fragrance/flavor material. The PMMA nanofibers were electrospun with CD-menthol-ICs using three type of CD: α-CD, β-CD, and γ-CD. Direct pyrolysis mass spectrometry (DP-MS) studies showed that the thermal evaporation of menthol occurred over a very high and a broad temperature range (100-355 deg. C) for PMMA/CDmenthol-IC nanowebs, demonstrating the complexation of menthol with the CD cavity and its high temperature stability. Furthermore, as the size of CD cavity increased in the order α-CD β-CD>α-CD.

Menthol's potential effects on nicotine dependence: a tobacco industry perspective.

Science.gov (United States)

Yerger, Valerie B

2011-05-01

To examine what the tobacco industry knows about the potential effects menthol may have on nicotine dependence. A snowball strategy was used to systematically search the Legacy Tobacco Documents Library (http://legacy.library.ucsf.edu/) between 22 February and 29 April, 2010. Of the approximately 11 million documents available in the Legacy Tobacco Documents Library, the iterative searches returned tens of thousands of results. We qualitatively analysed a final collection of 309 documents relevant the effects of menthol on nicotine dependence. The tobacco industry knows that menthol overrides the harsh taste of tobacco and alleviates nicotine's irritating effects, synergistically interacts with nicotine, stimulates the trigeminal nerve to elicit a 'liking' response for a tobacco product, and makes low tar, low nicotine tobacco products more acceptable to smokers than non-mentholated low delivery products. Menthol is not only used in cigarettes as a flavour additive; tobacco companies know that menthol also has sensory effects and interacts with nicotine to produce tobacco products that are easier to smoke, thereby making it easier to expose smokers, especially those who are new and uninitiated, to the addictive power of nicotine.

In Their Own Words: Young Adults' Menthol Cigarette Initiation, Perceptions, Experiences and Regulation Perspectives.

Science.gov (United States)

Wackowski, Olivia A; Evans, Kiameesha R; Harrell, Melissa B; Loukas, Alexandra; Lewis, M Jane; Delnevo, Cristine D; Perry, Cheryl L

2017-02-17

Menthol cigarettes are disproportionately used by young people and have been called smoking starter products. However, limited qualitative research exists on young adults' perceptions of and experiences with these products, with much of it based on document reviews of the tobacco industry's research. We conducted six focus groups with young adult (ages 18-24) menthol smokers in New Jersey (half with black smokers) between December 2014 and March 2015. Participants were asked open-ended questions about their menthol smoking initiation, preference reasons, substitution behaviors, and perceptions of menthol cigarette risks and regulation. Participants' menthol cigarette initiation and preference were influenced by their perceived popularity, brand recognition, taste, smoothness, satisfaction and access (including as "loosies," typically available for Newport). Some believed menthol cigarettes were less harmful than non-menthol cigarettes when initiating smoking. Many currently believed menthol cigarettes were more harmful because they contained extra "additives," were stronger (ie, requiring fewer cigarettes to feel satisfied), and/or based on hearsay. Many had tried new brand Camel Crush, which was perceived to be especially minty, fun, and attractive for newer smokers. While some used non-menthol cigarettes when menthols were unavailable, many said they would never or almost never substitute. Many acknowledged a menthol cigarettes ban would likely help them quit smoking, even though they did not support the idea. Menthol cigarette initiation is influenced by an interplay of multiple factors including their sensory properties, marketing, perceived popularity and availability. The FDA should continue to pursue closing this flavored cigarette loophole. In this first qualitative study of menthol cigarette use among young adults, we found further evidence that menthol cigarettes can act as starter products because they are perceived as easier to smoke and taste and smell

A cross-sectional study on tobacco use and dependence among women: Does menthol matter?

Science.gov (United States)

Rosenbloom, Judith; Rees, Vaughan W; Reid, Kathleen; Wong, Jeannie; Kinnunen, Taru

2012-11-27

The question of whether mentholation of cigarettes enhances tobacco dependence has generated conflicting findings. Potential mediating factors in a putative relationship between menthol use and tobacco dependence may include race and gender. While an association between menthol use and dependence is mixed, research on the role of race solely among women smokers is scarce. This study examined whether women menthol smokers have higher tobacco use and dependence than non-menthol smokers. Further, the study investigated differences between White and African American smokers. A cross-sectional study was conducted among 928 women seeking tobacco dependence treatment in Boston, Massachusetts. Measures obtained included preferred brand and menthol content, dependence markers (cigarettes per day (CPD); time to first cigarette in the morning; number of and longest previous quit attempts) and smoking history (age of initiation; years smoking; menthol or non-menthol cigarette preference). Analysis of variance (ANOVA) was used to detect interactions between menthol preference by race for continuous variables, and Pearson's chi-squared test was used for analyses with dichotomous variables. A greater proportion of menthol smokers smoked their first cigarette within five minutes of waking (p preferences. However, African American smokers smoked fewer CPD (pbrand for longer (p= .04). Women menthol smokers showed signs of greater tobacco dependence than non-menthol smokers. African Americans smoked fewer CPD but nevertheless had evidence of greater dependence.

78 FR 44484 - Menthol in Cigarettes, Tobacco Products; Request for Comments

Science.gov (United States)

2013-07-24

... on the access to, and the advertising and promotion of, the tobacco product, if the Secretary of HHS... could be substituted by manufacturers to maintain the effect or appeal of menthol to menthol cigarette... cessation? 2. Should FDA consider establishing restrictions on the advertising and promotion of menthol...

The role of menthol in cigarettes as a reinforcer of smoking behavior.

Science.gov (United States)

Ahijevych, Karen; Garrett, Bridgette E

2010-12-01

The World Health Organization has identified several additives such as menthol in the manufacturing of cigarettes to specifically reduce smoke harshness. These additives may have important implications for reinforcing smoking behavior and motivation to quit smoking. The purpose of this paper is to synthesize research related to the role of menthol's sensory characteristics in strengthening the reinforcing effects of nicotine in cigarettes and the impact on nicotine addiction and smoking behavior. Research reports from 2002 to 2010 on the addictive potential of menthol cigarettes were reviewed that included qualitative focus groups, self-reports and biomarkers of nicotine dependence, human laboratory, and epidemiological studies. Positive sensory effects of menthol cigarette use were identified via reports of early smoking experiences and as a potential starter product for smoking uptake in youth. Menthol cigarettes may serve as a conditioned stimulus that reinforces the rewarding effects of smoking. Nicotine dependence measured by shorter time-to-first cigarette upon waking was increased with menthol cigarette use in most of the studies reviewed. Smoking quit rates provide additional indicators of nicotine dependence, and the majority of the studies reviewed provided evidence of lower quit rates or higher relapse rates among menthol cigarette smokers. The effects of menthol cigarette use in increasing the reinforcing effects of nicotine on smoking behavior were evidenced in both qualitative and quantitative empirical studies. These findings have implications for enhanced prevention and cessation efforts in menthol smokers.

Lidocaine/L-Menthol Binary System: Cocrystallization versus Solid-State Immiscibility

OpenAIRE

Corvis , Yohann; Négrier , Philippe; Lazerges , Mathieu; Massip , Stéphane; Léger , Jean-Michel; Espeau , Philippe

2010-01-01

International audience; We present the synthesis, structure determination, and thermodynamic properties of a never reported cocrystal prepared with lidocaine and L-menthol. The temperature-composition phase diagram of the lidocaine/L-menthol binary system was achieved using differential scanning calorimetry and X-ray diffraction experiments. The present study demonstrates that the only way to perform a phase equilibrium survey of the lidocaine/L-menthol system is to prepare the binary mixture...

Tobacco industry control of menthol in cigarettes and targeting of adolescents and young adults.

Science.gov (United States)

Kreslake, Jennifer M; Wayne, Geoffrey Ferris; Alpert, Hillel R; Koh, Howard K; Connolly, Gregory N

2008-09-01

We examined whether tobacco manufacturers manipulate the menthol content of cigarettes in an effort to target adolescents and young adults. We analyzed data from tobacco industry documents describing menthol product development, results of laboratory testing of US menthol brands, market research reports, and the 2006 National Survey on Drug Use and Health. The tobacco industry attracted new smokers by promoting cigarettes with lower menthol content, which were popular with adolescents and young adults, and provided cigarettes with higher menthol content to long-term smokers. Menthol cigarette sales remained stable from 2000 to 2005 in the United States, despite a 22% decline in overall packs sold. Tobacco companies manipulate the sensory characteristics of cigarettes, including menthol content, thereby facilitating smoking initiation and nicotine dependence. Menthol brands that have used this strategy have been the most successful in attracting youth and young adult smokers and have grown in popularity.

International consensus statement on allergy and rhinology: allergic rhinitis-executive summary.

Science.gov (United States)

Wise, Sarah K; Lin, Sandra Y; Toskala, Elina

2018-02-01

The available allergic rhinitis (AR) literature continues to grow. Critical evaluation and understanding of this literature is important to appropriately utilize this knowledge in the care of AR patients. The International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR) has been produced as a multidisciplinary international effort. This Executive Summary highlights and summarizes the findings of the comprehensive ICAR:AR document. The ICAR:AR document was produced using previously described methodology. Specific topics were developed relating to AR. Each topic was assigned a literature review, evidence-based review (EBR), or evidence-based review with recommendations (EBRR) format as dictated by available evidence and purpose within the ICAR:AR document. Following iterative reviews of each topic, the ICAR:AR document was synthesized and reviewed by all authors for consensus. Over 100 individual topics related to AR diagnosis, pathophysiology, epidemiology, disease burden, risk factors, allergy testing modalities, treatment, and other conditions/comorbidities associated with AR were addressed in the comprehensive ICAR:AR document. Herein, the Executive Summary provides a synopsis of these findings. In the ICAR:AR critical review of the literature, several strengths were identified. In addition, significant knowledge gaps exist in the AR literature where current practice is not based on the best quality evidence; these should be seen as opportunities for additional research. The ICAR:AR document evaluates the strengths and weaknesses of the AR literature. This Executive Summary condenses these findings into a short summary. The reader is also encouraged to consult the comprehensive ICAR:AR document for a thorough description of this work. © 2018 ARS-AAOA, LLC.

E-Cigs, Menthol & Dip

Science.gov (United States)

... are many types of tobacco products. Learn how e-cigarettes, menthol cigarettes, smokeless tobacco, and other products are ... your health. What We Know About Electronic Cigarettes (E-cigarettes) Some people use e-cigs to quit smoking. ...

Menthol differs from other terpenic essential oil constituents.

Science.gov (United States)

Kolassa, Norbert

2013-02-01

The European Medicines Agency concluded that there is a risk of suppositories containing terpenic derivatives, which are used to treat coughs and colds, inducing neurological disorders, especially convulsions, in infants and small children. Terpenic derivatives are found in essential oils obtained from plants and include camphor, eucalyptol (syn. 1,8-cineol), thujone, and menthol. Chemistry, pharmacodynamics and pharmacokinetics of these compounds are clearly different and explain the appearance of convulsions following camphor, thujone, and eucalyptus oil overdose/poisoning, whereas no convulsions have been reported in cases of menthol overdose/poisoning in accordance with the pharmacological properties of menthol. Thus, a general verdict on all terpenic derivatives without differentiation appears inappropriate. Copyright © 2012 Elsevier Inc. All rights reserved.

Aircraft Battle Damage Assessment and Repair (ABDAR). Volume 1: Executive Summary

National Research Council Canada - National Science Library

Dierker, Ron

2000-01-01

.... This volume provides an executive summary and describes the overall program goals, the methodology used to develop the ABDAR technology and a demonstration system, and the results of a field test...

Executive summaries of reports leading to the construction of the Baca Geothermal Demonstration Project

Energy Technology Data Exchange (ETDEWEB)

Sherwood, P.B.; Newman, K.L.; Westermeier, J.F.; Giroux, H.D.; Lowe, G.D.; Nienberg, M.W.

1980-05-01

Executive summaries have been written for 61 reports and compilations of data which, in part, have led to the construction of the Baca 50 MW Geothermal Demonstration Project (GDP). The reports and data include environmental research, reservoir and feasibility studies, the project proposal to DOE and the Final Environmental Impact Statement. These executive summaries are intended to give the reader a general overview of each report prior to requesting the report from the GDP Data Manager.

Executive summaries of reports leading to the construction of the Baca Geothermal Demonstration Project

Energy Technology Data Exchange (ETDEWEB)

Sherwood, P.B.; Newman, K.L.; Westermeier, J.F.; Giroux, H.D.; Lowe, G.D.; Nienberg, M.W.

1980-05-01

Executive summaries have been written for 61 reports and compilations of data which in part, have led to the construction of the Baca 50 MW Geothermal Demonstration Project (GDP). The reports and data include environmental research, reservoir and feasibility studies, the project proposal to DOE and the Final Environmental Impact Statement. These executive summaries are intended to give the reader a general overview of each report prior to requesting the report from the GDP Data Manager.

The College Payoff: Education, Occupations, Lifetime Earnings. Executive Summary

Science.gov (United States)

Carnevale, Anthony P.; Rose, Stephen J.; Cheah, Ban

2011-01-01

Education and earnings interact in complex and often unexpected ways--but there are rules to the game. "The College Payoff," a new paper from the Georgetown University Center on Education and the Workforce, uses in-depth data analysis to identify, illuminate and elucidate those rules. This executive summary provides a glimpse of the education and…

AASHTO transportation asset management guide : a focus on implementation executive summary.

Science.gov (United States)

2013-06-01

This AASHTO Transportation Asset Management Executive Summary serves as a companion to the AASHTO Transportation : Asset Management GuideA Focus on Implementation, which takes as a starting point the Transportation : Asset Management Guide publish...

Malawi : Country Procurement Assessment Report, Volume 3. Executive Summary

OpenAIRE

World Bank

2004-01-01

The Malawi Country Procurement Assessment Report is a joint undertaking between the Malawi Government and the World Bank to analyze the country procurement system and recommend appropriate actions to improve the efficiency, economy and transparency of the system. This report is divided into (a) an Executive Summary, (b) Main Report on Findings and Recommendations, and (c) Annexes. Since th...

Studying the interactive effects of menthol and nicotine among youth: An examination using e-cigarettes.

Science.gov (United States)

Krishnan-Sarin, Suchitra; Green, Barry G; Kong, Grace; Cavallo, Dana A; Jatlow, Peter; Gueorguieva, Ralitza; Buta, Eugenia; O'Malley, Stephanie S

2017-11-01

Tobacco products containing menthol are widely used by youth. We used e-cigarettes to conduct an experimental evaluation of the independent and interactive effects of menthol and nicotine among youth. Pilot chemosensory experiments with fourteen e-cigarette users identified low (barely perceptible, 0.5%) and high (similar to commercial e-liquid, 3.5%) menthol concentrations. Sixty e-cigarette users were randomized to a nicotine concentration (0mg/ml, 6mg/ml, 12mg/ml) and participated in 3 laboratory sessions. During each session, they received their assigned nicotine concentration, along with one of three menthol concentrations in random counterbalanced order across sessions (0, 0.5%, 3.5%), and participated in three fixed-dose, and an ad-lib, puffing period. Urinary menthol glucuronide and salivary nicotine levels validated menthol and nicotine exposure. We examined changes in e-cigarette liking/wanting and taste, coolness, stimulant effects, nicotine withdrawal and ad-lib use. Overall, the high concentration of menthol (3.5%) significantly increased e-cigarette liking/wanting relative to no menthol (pe-cigarettes among youth. Further, menthol enhances positive rewarding effects of high nicotine-containing e-cigarettes among youth. Copyright © 2017 Elsevier B.V. All rights reserved.

The role of trigeminal nasal TRPM8-expressing afferent neurons in the antitussive effects of menthol.

Science.gov (United States)

Plevkova, J; Kollarik, M; Poliacek, I; Brozmanova, M; Surdenikova, L; Tatar, M; Mori, N; Canning, B J

2013-07-15

The cold-sensitive cation channel TRPM8 is a target for menthol, which is used routinely as a cough suppressant and as an additive to tobacco and food products. Given that cold temperatures and menthol activate neurons through gating of TRPM8, it is unclear how menthol actively suppresses cough. In this study we describe the antitussive effects of (-)-menthol in conscious and anesthetized guinea pigs. In anesthetized guinea pigs, cough evoked by citric acid applied topically to the tracheal mucosa was suppressed by menthol only when it was selectively administered as vapors to the upper airways. Menthol applied topically to the tracheal mucosa prior to and during citric acid application or administered continuously as vapors or as an aerosol to the lower airways was without effect on cough. These actions of upper airway menthol treatment were mimicked by cold air delivered to the upper airways but not by (+)-menthol, the inactive isomer of menthol, or by the TRPM8/TRPA1 agonist icilin administered directly to the trachea. Subsequent molecular analyses confirmed the expression of TRPM8 in a subset of nasal trigeminal afferent neurons that do not coincidently express TRPA1 or TRPV1. We conclude that menthol suppresses cough evoked in the lower airways primarily through a reflex initiated from the nose.

Influence of menthol on caffeine disposition and pharmacodynamics in healthy female volunteers.

Science.gov (United States)

Gelal, Ayse; Guven, Hulya; Balkan, Dilara; Artok, Levent; Benowitz, Neal L

2003-09-01

The present study was undertaken to determine whether a single oral dose of menthol affects the metabolism of caffeine, a cytochrome P(450) 1A2 (CYP1A2) substrate, and pharmacological responses to caffeine in people. Eleven healthy female subjects participated in a randomized, double-blind, two-way crossover study, comparing the kinetics and effects of a single oral dose of caffeine (200 mg) in coffee taken together with a single oral dose of menthol (100 mg) or placebo capsules. Serum caffeine concentrations and cardiovascular and subjective parameters were measured throughout the study. Co-administration of menthol resulted in an increase of caffeine t(max) values from 43.6+/-20.6 min (mean+/-SD) to 76.4+/-28.0 min ( P<0.05). The C(max) values of caffeine were lower in the menthol phase than in the placebo phase, but this effect was not statistically significant ( P=0.06). (AUC)(0-24), (AUC)(0- infinity ), terminal half-life and oral clearance were not affected by menthol. Only nine subjects' cardiovascular data were included in the analysis because of technical problems during the measurements. After caffeine, heart rate decreased in both treatment phases. The maximum decrease in heart rate was less in the menthol phase (-8.9+/-3.9 beats/min) than in the placebo phase (-13.1+/-2.1 beats/min) ( P=0.024). There were no statistically significant differences in systolic and diastolic blood pressures between the two treatments. We conclude that a single oral dose of pure menthol (100 mg) delays caffeine absorption and blunts the heart-rate slowing effect of caffeine, but does not affect caffeine metabolism. The possibility that menthol slows the absorption of other drugs should be considered.

The marketing of menthol cigarettes in the United States: populations, messages, and channels.

Science.gov (United States)

Sutton, Charyn D; Robinson, Robert G

2004-02-01

This commentary looks at the marketing menthol cigarettes to various targeted populations--women, middle school youth and Asian/Pacific Islander immigrants as well as African Americans. The authors take the position that "ethnic awareness" as evidenced in the advertising of menthol cigarette brands to African Americans is just one of four distinct messages that tobacco marketers have used for what they have termed the "coolness" category. The other messages are: healthy/medicinal; fresh/refreshing/cool/clean/crisp; and youthfulness/silliness and fun. The commentary poses three questions: (a) Are new population segments being steered toward menthol cigarettes using marketing approaches that are similar to what has occurred with African Americans and women? (b) What exactly is the relationship between the marketing of menthol cigarettes and subsequent use of menthol tobacco products by specific population subgroups? (c) Are there lessons to be learned from the marketing of menthol cigarettes that can be used to improve the public health and medical communities' smoking cessation and tobacco use prevention communications efforts?

The Allied Dental Professions: Executive Summary.

Science.gov (United States)

Fried, Jacquelyn L

2017-09-01

This executive summary for Section 5 of the "Advancing Dental Education in the 21 st Century" project addresses the current and future educational systems for dental assisting, dental hygiene, dental therapy, and dental laboratory technology. Nineteen experts prepared six background articles on the educational changes necessary for future roles and practices. The key issues addressed relate to delivery system changes, educational curricula, scopes of practice, regulatory measures, and the public's oral health. The major finding is that substantial reforms will be needed to adequately prepare allied oral health professionals for the changes anticipated in 2040. A reconsideration of current accreditation guidelines, more flexibility with scopes of practice, and an adherence to rigorous academic programs are essential elements for the future of these professions.

"AfterZone:" Outcomes for Youth Participating in Providence's Citywide After-School System. Executive Summary

Science.gov (United States)

Kauh, Tina J.

2011-01-01

This executive summary highlights the main findings from our participation and outcomes analysis of the "AfterZone" initiative--a citywide system-building effort in Providence, Rhode Island, that aims to provide high-quality, accessible out-of-school-time services to middle school youth. The summary briefly defines the AfterZone's unique…

Design, scale up and safe piloting of thymol hydrogenation and menthol racemisation

CSIR Research Space (South Africa)

Dudas, J

2009-01-01

Full Text Available of Chemical Process Fundamentals CAS, 16502 Prague 6, Czech Republic, Fax: +420 220 920 661, Tel: +420 220 390 286, E-mail: hanika@icpf.cas.cz Abstract The hydrogenation of thymol and the racemisation of a menthol mixture were investigated as part... thymol concentration in the feed (above 40% wt.) and because of equipment, operation and power failure. Key words: Thymol hydrogenation, menthol racemisation, trickle-bed reactor, gas-liquid-solid reaction Introduction Menthol is one...

Ingestion of a cold temperature/menthol beverage increases outdoor exercise performance in a hot, humid environment.

Science.gov (United States)

Tran Trong, Than; Riera, Florence; Rinaldi, Kévin; Briki, Walid; Hue, Olivier

2015-01-01

A recent laboratory study demonstrated that the ingestion of a cold/menthol beverage improved exercise performance in a hot and humid environment during 20 km of all-out cycling. Therefore, the aim of this study was to determine whether the ingestion of cold water/ice-slurry with menthol would improve performance in hot and humid outdoor conditions. Ten trained males completed three trials of five blocks consisting of 4-km cycling and 1.5-km running. During warm-up, every block and recovery, the athletes drank 190 ml of aromatized (i.e., with 0.05 mL of menthol) beverage at three temperatures: Neutral (ambient temperature) (28.7°C±0. 5°C), Cold (3.1°C±0.6°C) or Ice-slurry (0.17°C±0.07°C). Trial time, core temperature (Tco), heart rate (HR), rate of perceived exertion (RPE), thermal sensation (TS) and thermal comfort (TC) were assessed. Ice-slurry/menthol increased performance by 6.2% and 3.3% compared with neutral water/menthol and cold water/menthol, respectively. No between-trial differences were noted for Tco, HR, RPE, TC and TS was lower with ice-slurry/menthol and cold water/menthol compared with neutral water/menthol. A low drink temperature combined with menthol lessens the performance decline in hot/humid outdoor conditions (i.e., compared with cold water alone). Performances were better with no difference in psycho-physiological stress (Tco, HR and RPE) between trials. The changes in perceptual parameters caused by absorbing a cold/menthol beverage reflect the psychological impact. The mechanism leading to these results seems to involve brain integration of signals from physiological and psychological sources.

Executive Summary High-Yield Scenario Workshop Series Report

Energy Technology Data Exchange (ETDEWEB)

Leslie Park Ovard; Thomas H. Ulrich; David J. Muth Jr.; J. Richard Hess; Steven Thomas; Bryce Stokes

2009-12-01

To get a collective sense of the impact of research and development (R&D) on biomass resource availability, and to determine the feasibility that yields higher than baseline assumptions used for past assessments could be achieved to support U.S. energy independence, an alternate “High-Yield Scenario” (HYS) concept was presented to industry experts at a series of workshops held in December 2009. The workshops explored future production of corn/agricultural crop residues, herbaceous energy crops (HECs), and woody energy crops (WECs). This executive summary reports the findings of that workshop.

The effect of inhaled menthol on upper airway resistance in humans: A randomized controlled crossover study

Directory of Open Access Journals (Sweden)

Effie J Pereira

2013-01-01

Full Text Available BACKGROUND: Menthol (l-menthol is a naturally-occurring cold receptor agonist commonly used to provide symptomatic relief for upper airway congestion. Menthol can also reduce the sensation of dyspnea. It is unclear whether the physiological action of menthol in dyspnea reduction is through its cold receptor agonist effect or whether associated mechanical changes occur in the upper airway.

Effect of Menthol on Respiratory and Perceptual Responses to Exercise in Firefighter Protective Gear

Directory of Open Access Journals (Sweden)

Yang Zhang

2015-09-01

Full Text Available Impaired respiration reduces firefighters’ work capacity. This study evaluated the effect of menthol lozenge on respiratory and perceptual responses during exercise in a hot environment. Ten participants wearing firefighter protective gear performed two repeated exercise and rest trials in a counter-balanced order. Exercise consisted of two bouts of 20-min treadmill exercise at 60% of maximal oxygen uptake and one bout of 20-min stepping exercise at a wet bulb global temperature of 35°C. Participants either took 10-mg menthol or control lozenges prior to the beginning of each exercise bout. Respiratory gas exchange, heart rate, thermal sensation, and breathing comfort were continuously recorded. Menthol lozenges significantly increased pulmonary ventilation (menthol: 45.0±6.6 L•min-1 vs. control: 41.4±5.8 L•min-1 and menthol: 52.7±9.7 L•min-1 vs. control: 46.5±7.0 L•min-1, for the 1st and 2nd treadmill exercise, respectively and oxygen consumption (menthol: 26.7±2.0 ml•kg-1•min-1 vs. control: 25.2±2.3 ml•kg-1•min-1 and menthol: 28.8±2.3 ml•kg-1•min-1 vs. control: 26.9±1.9 ml•kg-1•min-1, for the 1st and 2nd treadmill exercise, respe¬cti¬ve¬ly (p0.05. The ventilatory equivalents though were not different throughout the exercise (p>0.05. Ratings of thermal sensation and breathing comfort were not different (p>0.05. It was concluded that menthol could alter breathing pattern and increase respiratory responses during strenuous exercise in the heat. There was no favorable effect of menthol on respiratory or perceptual responses under exercise-heat stress.

A Second Year Evaluation Study of Promethean ActivClassroom. Executive Summary

Science.gov (United States)

Marzano Research Laboratory, 2010

2010-01-01

During the 2009-2010 school year, Marzano Research Laboratory (MRL) was commissioned by Promethean Ltd. to conduct a second year evaluation study of the effects of Promethean ActivClassroom on student academic achievement. This executive summary highlights the key findings. [For "A Second Year Evaluation Study of Promethean ActivClassroom. Final…

The menthol marketing mix: targeted promotions for focus communities in the United States.

Science.gov (United States)

Cruz, Tess Boley; Wright, La Tanisha; Crawford, George

2010-12-01

This study analyzes tobacco industry menthol marketing strategies aimed at urban predominantly Black populations. Data are drawn from an interview with a former Brown & Williamson Tobacco Company trade marketing manager, tobacco industry documents on Kool promotions in urban areas, and public health literature on tobacco marketing. Tobacco companies recognize the growth potential for the menthol segment in these urban communities. They have higher levels of price discounts and signage, exert tight controls over the retail environment, and use hip-hop lifestyle to associate menthol products with urban nightlife, music, fame, and cultural edginess among younger smokers. Tobacco companies regard the urban Black menthol segment as one of the few markets in which they can grow sales despite declines elsewhere in the United States. Consequently, this population is surrounded by intense and integrated levels of marketing. We need strong monitoring, regulation, and enforcement efforts that will counter the industry's use of menthol at multiple levels in urban environments.

Vapor pressures and vaporization enthalpy of (−) α-bisabolol and (dl) menthol by correlation gas chromatography

International Nuclear Information System (INIS)

Keating, Leasa; Harris, Harold H.; Chickos, James S.

2017-01-01

Highlights: • The vaporization enthalpy and vapor pressure of (−) α-bisabolol and (dl)-menthol have been measured as a function of temperature. • Vapor pressures, vaporization enthalpies and boiling temperatures have been compared to available literature data. • Vapor pressures of (l)-menthol are compared to (dl)-menthol. - Abstract: The vapor pressures and vaporization enthalpies of (−) α-bisabolol and (dl)-menthol, two GRAS chemicals (generally recognized as safe) are evaluated by correlation gas chromatography using a series of saturated primary alcohols as standards. Vaporization enthalpies of (96.6 ± 2.4) and (74.2 ± 2.8) kJ mol −1 and vapor pressures of p/Pa = (0.020 ± 0.003) and (4.5 ± 0.44) were evaluated at T = 298.15 K for (−) α-bisabolol and (dl)-menthol, respectively, and compared to literature values. The vapor pressures of both compounds from T = (298.15 to 500) K have been derived from correlations using vapor pressures of a series of 1-alkanols and corresponding gas chromatographic retention times at 10 K intervals. The results were fit to a second order polynomial. Calculated normal boiling temperatures of T B = (574.8 and 492.7) K are calculated for (−) α-bisabolol and (dl)-menthol, respectively. A normal boiling temperature of T B = (485.2, and 489.7) K has previously been reported for (dl)-menthol. Vapor pressures for both (l)-menthol and (dl)-menthol from a previous study and (dl)-menthol from this study are compared with literature values.

Ingestion of a cold temperature/menthol beverage increases outdoor exercise performance in a hot, humid environment.

Directory of Open Access Journals (Sweden)

Than Tran Trong

Full Text Available A recent laboratory study demonstrated that the ingestion of a cold/menthol beverage improved exercise performance in a hot and humid environment during 20 km of all-out cycling. Therefore, the aim of this study was to determine whether the ingestion of cold water/ice-slurry with menthol would improve performance in hot and humid outdoor conditions.Ten trained males completed three trials of five blocks consisting of 4-km cycling and 1.5-km running. During warm-up, every block and recovery, the athletes drank 190 ml of aromatized (i.e., with 0.05 mL of menthol beverage at three temperatures: Neutral (ambient temperature (28.7°C±0. 5°C, Cold (3.1°C±0.6°C or Ice-slurry (0.17°C±0.07°C. Trial time, core temperature (Tco, heart rate (HR, rate of perceived exertion (RPE, thermal sensation (TS and thermal comfort (TC were assessed.Ice-slurry/menthol increased performance by 6.2% and 3.3% compared with neutral water/menthol and cold water/menthol, respectively. No between-trial differences were noted for Tco, HR, RPE, TC and TS was lower with ice-slurry/menthol and cold water/menthol compared with neutral water/menthol.A low drink temperature combined with menthol lessens the performance decline in hot/humid outdoor conditions (i.e., compared with cold water alone. Performances were better with no difference in psycho-physiological stress (Tco, HR and RPE between trials. The changes in perceptual parameters caused by absorbing a cold/menthol beverage reflect the psychological impact. The mechanism leading to these results seems to involve brain integration of signals from physiological and psychological sources.

Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: executive summary

NARCIS (Netherlands)

Magee, Laura A.; Pels, Anouk; Helewa, Michael; Rey, Evelyne; von Dadelszen, Peter; Audibert, Francois; Bujold, Emmanuel; Côté, Anne-Marie; Douglas, Myrtle Joanne; Eastabrook, Genevieve; Firoz, Tabassum; Gibson, Paul; Gruslin, Andrée; Hutcheon, Jennifer; Koren, Gideon; Lange, Ian; Leduc, Line; Logan, Alexander G.

2014-01-01

This executive summary presents in brief the current evidence assessed in the clinical practice guideline prepared by the Canadian Hypertensive Disorders of Pregnancy Working Group and published by Pregnancy Hypertension (http://www.pregnancyhypertension.org/article/S2210-7789(14)00004-X/fulltext)

Workers in an Integrating World. World Development Report, 1995. Executive Summary.

Science.gov (United States)

World Bank, Washington, DC.

This executive summary examines the rapid changes occurring in economic markets and employment around the world. The report concludes that problems of low incomes, poor working conditions, and insecurity affecting many of the world's workers can be tackled effectively in ways that reduce poverty and regional inequality. Sound domestic policy and a…

Systematic review of the epidemiological evidence comparing lung cancer risk in smokers of mentholated and unmentholated cigarettes

Directory of Open Access Journals (Sweden)

Lee Peter N

2011-04-01

Full Text Available Abstract Background US mentholated cigarette sales have increased considerably over 50 years. Preference for mentholated cigarettes is markedly higher in Black people. While menthol itself is not genotoxic or carcinogenic, its acute respiratory effects might affect inhalation of cigarette smoke. This possibility seems consistent with the higher lung cancer risk in Black men, despite Black people smoking less and starting smoking later than White people. Despite experimental data suggesting similar carcinogenicity of mentholated and non-mentholated cigarettes, the lack of convincing evidence that mentholation increases puffing, inhalation or smoke uptake, and the similarity of lung cancer rates in Black and White females, a review of cigarette mentholation and lung cancer is timely given current regulatory interest in the topic. Methods Epidemiological studies comparing lung cancer risk in mentholated and non-mentholated cigarette smokers were identified from MedLine and other sources. Study details were extracted and strengths and weaknesses assessed. Relative risk estimates were extracted, or derived, for ever mentholated use and for long-term use, overall and by gender, race, and current/ever smoking, and meta-analyses conducted. Results Eight generally good quality studies were identified, with valid cases and controls, and appropriate adjustment for age, gender, race and smoking. The studies afforded good power to detect possible effects. However, only one study presented results by histological type, none adjusted for occupation or diet, and some provided no results by length of mentholated cigarette use. The data do not suggest any effect of mentholation on lung cancer risk. Adjusted relative risk estimates for ever use vary from 0.81 to 1.12, giving a combined estimate of 0.93 (95% confidence interval 0.84-1.02, n = 8, with no increase in males (1.01, 0.84-1.22, n = 5, females (0.80, 0.67-0.95, n = 5, White people (0.87, 0.75-1.03, n = 4

Systematic review of the epidemiological evidence comparing lung cancer risk in smokers of mentholated and unmentholated cigarettes

Science.gov (United States)

2011-01-01

Background US mentholated cigarette sales have increased considerably over 50 years. Preference for mentholated cigarettes is markedly higher in Black people. While menthol itself is not genotoxic or carcinogenic, its acute respiratory effects might affect inhalation of cigarette smoke. This possibility seems consistent with the higher lung cancer risk in Black men, despite Black people smoking less and starting smoking later than White people. Despite experimental data suggesting similar carcinogenicity of mentholated and non-mentholated cigarettes, the lack of convincing evidence that mentholation increases puffing, inhalation or smoke uptake, and the similarity of lung cancer rates in Black and White females, a review of cigarette mentholation and lung cancer is timely given current regulatory interest in the topic. Methods Epidemiological studies comparing lung cancer risk in mentholated and non-mentholated cigarette smokers were identified from MedLine and other sources. Study details were extracted and strengths and weaknesses assessed. Relative risk estimates were extracted, or derived, for ever mentholated use and for long-term use, overall and by gender, race, and current/ever smoking, and meta-analyses conducted. Results Eight generally good quality studies were identified, with valid cases and controls, and appropriate adjustment for age, gender, race and smoking. The studies afforded good power to detect possible effects. However, only one study presented results by histological type, none adjusted for occupation or diet, and some provided no results by length of mentholated cigarette use. The data do not suggest any effect of mentholation on lung cancer risk. Adjusted relative risk estimates for ever use vary from 0.81 to 1.12, giving a combined estimate of 0.93 (95% confidence interval 0.84-1.02, n = 8), with no increase in males (1.01, 0.84-1.22, n = 5), females (0.80, 0.67-0.95, n = 5), White people (0.87, 0.75-1.03, n = 4) or Black people (0.90, 0

ILC Reference Design Report Volume 1 - Executive Summary

CERN Document Server

Brau, James; Walker, Nicholas; Aarons, Gerald; Abe, Toshinori; Abernathy, Jason; Ablikim, Medina; Abramowicz, Halina; Adey, David; Adloff, Catherine; Adolphsen, Chris; Afanaciev, Konstantin; Agapov, Ilya; Ahn, Jung-Keun; Aihara, Hiroaki; Akemoto, Mitsuo; del Carmen Alabau, Maria; Albert, Justin; Albrecht, Hartwig; Albrecht, Michael; Alesini, David; Alexander, Gideon; Alexander, Jim; Allison, Wade; Amann, John; Amirikas, Ramila; An, Qi; Anami, Shozo; Ananthanarayan, B.; Anderson, Terry; Andricek, Ladislav; Anduze, Marc; Anerella, Michael; Anfimov, Nikolai; Angal-Kalinin, Deepa; Antipov, Sergei; Antoine, Claire; Aoki, Mayumi; Aoza, Atsushi; Aplin, Steve; Appleby, Rob; Arai, Yasuo; Araki, Sakae; Arkan, Tug; Arnold, Ned; Arnold, Ray; Arnowitt, Richard; Artru, Xavier; Arya, Kunal; Aryshev, Alexander; Asakawa, Eri; Asiri, Fred; Asner, David; Atac, Muzaffer; Atoian, Grigor; Attié, David; Augustin, Jean-Eudes; Augustine, David B.; Ayres, Bradley; Aziz, Tariq; Baars, Derek; Badaud, Frederique; Baddams, Nigel; Bagger, Jonathan; Bai, Sha; Bailey, David; Bailey, Ian R.; Baker, David; Balalykin, Nikolai I.; Balbuena, Juan Pablo; Baldy, Jean-Luc; Ball, Markus; Ball, Maurice; Ballestrero, Alessandro; Ballin, Jamie; Baltay, Charles; Bambade, Philip; Ban, Syuichi; Band, Henry; Bane, Karl; Banerjee, Bakul; Barbanotti, Serena; Barbareschi, Daniele; Barbaro-Galtieri, Angela; Barber, Desmond P.; Barbi, Mauricio; Bardin, Dmitri Y.; Barish, Barry; Barklow, Timothy L.; Barlow, Roger; Barnes, Virgil E.; Barone, Maura; Bartels, Christoph; Bartsch, Valeria; Basu, Rahul; Battaglia, Marco; Batygin, Yuri; Baudot, Jerome; Baur, Ulrich; Elwyn Baynham, D.; Beard, Carl; Bebek, Chris; Bechtle, Philip; Becker, Ulrich J.; Bedeschi, Franco; Bedjidian, Marc; Behera, Prafulla; Behnke, Ties; Bellantoni, Leo; Bellerive, Alain; Bellomo, Paul; Bentson, Lynn D.; Benyamna, Mustapha; Bergauer, Thomas; Berger, Edmond; Bergholz, Matthias; Beri, Suman; Berndt, Martin; Bernreuther, Werner; Bertolini, Alessandro; Besancon, Marc; Besson, Auguste; Beteille, Andre; Bettoni, Simona; Beyer, Michael; Bhandari, R.K.; Bharadwaj, Vinod; Bhatnagar, Vipin; Bhattacharya, Satyaki; Bhattacharyya, Gautam; Bhattacherjee, Biplob; Bhuyan, Ruchika; Bi, Xiao-Jun; Biagini, Marica; Bialowons, Wilhelm; Biebel, Otmar; Bieler, Thomas; Bierwagen, John; Birch, Alison; Bisset, Mike; Biswal, S.S.; Blackmore, Victoria; Blair, Grahame; Blanchard, Guillaume; Blazey, Gerald; Blue, Andrew; Blümlein, Johannes; Boffo, Christian; Bohn, Courtlandt; Boiko, V.I.; Boisvert, Veronique; Bondarchuk, Eduard N.; Boni, Roberto; Bonvicini, Giovanni; Boogert, Stewart; Boonekamp, Maarten; Boorman, Gary; Borras, Kerstin; Bortoletto, Daniela; Bosco, Alessio; Bosio, Carlo; Bosland, Pierre; Bosotti, Angelo; Boudry, Vincent; Boumediene, Djamel-Eddine; Bouquet, Bernard; Bourov, Serguei; Bowden, Gordon; Bower, Gary; Boyarski, Adam; Bozovic-Jelisavcic, Ivanka; Bozzi, Concezio; Brachmann, Axel; Bradshaw, Tom W.; Brandt, Andrew; Brasser, Hans Peter; Brau, Benjamin; Breidenbach, Martin; Bricker, Steve; Brient, Jean-Claude; Brock, Ian; Brodsky, Stanley; Brooksby, Craig; Broome, Timothy A.; Brown, David; Brown, David; Brownell, James H.; Bruchon, Mélanie; Brueck, Heiner; Brummitt, Amanda J.; Brun, Nicole; Buchholz, Peter; Budagov, Yulian A.; Bulgheroni, Antonio; Bulyak, Eugene; Bungau, Adriana; Bürger, Jochen; Burke, Dan; Burkhart, Craig; Burrows, Philip; Burt, Graeme; Burton, David; Büsser, Karsten; Butler, John; Butterworth, Jonathan; Buzulutskov, Alexei; Cabruja, Enric; Caccia, Massimo; Cai, Yunhai; Calcaterra, Alessandro; Caliier, Stephane; Camporesi, Tiziano; Cao, Jun-Jie; Cao, J.S.; Capatina, Ofelia; Cappellini, Chiara; Carcagno, Ruben; Carena, Marcela; Carloganu, Cristina; Carosi, Roberto; Stephen Carr, F.; Carrion, Francisco; Carter, Harry F.; Carter, John; Carwardine, John; Cassel, Richard; Cassell, Ronald; Cavallari, Giorgio; Cavallo, Emanuela; Cembranos, Jose A.R.; Chakraborty, Dhiman; Chandez, Frederic; Charles, Matthew; Chase, Brian; Chattopadhyay, Subhasis; Chauveau, Jacques; Chefdeville, Maximilien; Chehab, Robert; Chel, Stéphane; Chelkov, Georgy; Chen, Chiping; Chen, He Sheng; Chen, Huai Bi; Chen, Jia Er; Chen, Sen Yu; Chen, Shaomin; Chen, Shenjian; Chen, Xun; Chen, Yuan Bo; Cheng, Jian; Chevallier, M.; Chi, Yun Long; Chickering, William; Cho, Gi-Chol; Cho, Moo-Hyun; Choi, Jin-Hyuk; Choi, Jong Bum; Choi, Seong Youl; Choi, Young-Il; Choudhary, Brajesh; Choudhury, Debajyoti; Rai Choudhury, S.; Christian, David; Christian, Glenn; Christophe, Grojean; Chung, Jin-Hyuk; Church, Mike; Ciborowski, Jacek; Cihangir, Selcuk; Ciovati, Gianluigi; Clarke, Christine; Clarke, Don G.; Clarke, James A.; Clements, Elizabeth; Coca, Cornelia; Coe, Paul; Cogan, John; Colas, Paul; Collard, Caroline; Colledani, Claude; Combaret, Christophe; Comerma, Albert; Compton, Chris; Constance, Ben; Conway, John; Cook, Ed; Cooke, Peter; Cooper, William; Corcoran, Sean; Cornat, Rémi; Corner, Laura; Cortina Gil, Eduardo; Clay Corvin, W.; Cotta Ramusino, Angelo; Cowan, Ray; Crawford, Curtis; Cremaldi, Lucien M; Crittenden, James A.; Cussans, David; Cvach, Jaroslav; da Silva, Wilfrid; Dabiri Khah, Hamid; Dabrowski, Anne; Dabrowski, Wladyslaw; Dadoun, Olivier; Dai, Jian Ping; Dainton, John; Daly, Colin; Damerell, Chris; Danilov, Mikhail; Daniluk, Witold; Daram, Sarojini; Datta, Anindya; Dauncey, Paul; David, Jacques; Davier, Michel; Davies, Ken P.; Dawson, Sally; De Boer, Wim; De Curtis, Stefania; De Groot, Nicolo; de la Taille, Christophe; de Lira, Antonio; De Roeck, Albert; de Sangro, Riccardo; De Santis,Stefano; Deacon, Laurence; Deandrea, Aldo; Dehmelt, Klaus; Delagnes, Eric; Delahaye, Jean-Pierre; Delebecque, Pierre; Delerue, Nicholas; Delferriere, Olivier; Demarteau, Marcel; Deng, Zhi; Denisov, Yu.N.; Densham, Christopher J.; Desch, Klaus; Deshpande, Nilendra; Devanz, Guillaume; Devetak, Erik; Dexter, Amos; Di benedetto, Vito; Diéguez, Angel; Diener, Ralf; Dinh, Nguyen Dinh; Dixit, Madhu; Dixit, Sudhir; Djouadi, Abdelhak; Dolezal, Zdenek; Dollan, Ralph; Dong, Dong; Dong, Hai Yi; Dorfan, Jonathan; Dorokhov, Andrei; Doucas, George; Downing, Robert; Doyle, Eric; Doziere, Guy; Drago, Alessandro; Dragt, Alex; Drake, Gary; Drásal, Zbynek; Dreiner, Herbert; Drell, Persis; Driouichi, Chafik; Drozhdin, Alexandr; Drugakov, Vladimir; Du, Shuxian; Dugan, Gerald; Duginov, Viktor; Dulinski, Wojciech; Dulucq, Frederic; Dutta, Sukanta; Dwivedi, Jishnu; Dychkant, Alexandre; Dzahini, Daniel; Eckerlin, Guenter; Edwards, Helen; Ehrenfeld, Wolfgang; Ehrlichman, Michael; Ehrlichmann, Heiko; Eigen, Gerald; Elagin, Andrey; Elementi, Luciano; Eliasson, Peder; Ellis, John; Ellwood, George; Elsen, Eckhard; Emery, Louis; Enami, Kazuhiro; Endo, Kuninori; Enomoto, Atsushi; Eozénou, Fabien; Erbacher, Robin; Erickson, Roger; Oleg Eyser, K.; Fadeyev, Vitaliy; Fang, Shou Xian; Fant, Karen; Fasso, Alberto; Faucci Giannelli, Michele; Fehlberg, John; Feld, Lutz; Feng, Jonathan L.; Ferguson, John; Fernandez-Garcia, Marcos; Luis Fernandez-Hernando, J.; Fiala, Pavel; Fieguth, Ted; Finch, Alexander; Finocchiaro, Giuseppe; Fischer, Peter; Fisher, Peter; Eugene Fisk, H.; Fitton, Mike D.; Fleck, Ivor; Fleischer, Manfred; Fleury, Julien; Flood, Kevin; Foley, Mike; Ford, Richard; Fortin, Dominique; Foster, Brian; Fourches, Nicolas; Francis, Kurt; Frey, Ariane; Frey, Raymond; Friedsam, Horst; Frisch, Josef; Frishman, Anatoli; Fuerst, Joel; Fujii, Keisuke; Fujimoto, Junpei; Fukuda, Masafumi; Fukuda, Shigeki; Funahashi, Yoshisato; Funk, Warren; Furletova, Julia; Furukawa, Kazuro; Furuta, Fumio; Fusayasu, Takahiro; Fuster, Juan; Gadow, Karsten; Gaede, Frank; Gaglione, Renaud; Gai, Wei; Gajewski, Jan; Galik, Richard; Galkin, Alexei; Galkin, Valery; Gallin-Martel, Laurent; Gannaway, Fred; Gao, Jian She; Gao, Jie; Gao, Yuanning; Garbincius, Peter; Garcia-Tabares, Luis; Garren, Lynn; Garrido, Luís; Garutti, Erika; Garvey, Terry; Garwin, Edward; Gascón, David; Gastal, Martin; Gatto, Corrado; Gatto, Raoul; Gay, Pascal; Ge, Lixin; Ge, Ming Qi; Ge, Rui; Geiser, Achim; Gellrich, Andreas; Genat, Jean-Francois; Geng, Zhe Qiao; Gentile, Simonetta; Gerbick, Scot; Gerig, Rod; Ghosh, Dilip Kumar; Ghosh, Kirtiman; Gibbons, Lawrence; Giganon, Arnaud; Gillespie, Allan; Gillman, Tony; Ginzburg, Ilya; Giomataris, Ioannis; Giunta, Michele; Gladkikh, Peter; Gluza, Janusz; Godbole, Rohini; Godfrey, Stephen; Goldhaber, Gerson; Goldstein, Joel; Gollin, George D.; Gonzalez-Sanchez, Francisco Javier; Goodrick, Maurice; Gornushkin, Yuri; Gostkin, Mikhail; Gottschalk, Erik; Goudket, Philippe; Gough Eschrich, Ivo; Gournaris, Filimon; Graciani, Ricardo; Graf, Norman; Grah, Christian; Grancagnolo, Francesco; Grandjean, Damien; Grannis, Paul; Grassellino, Anna; Graugés, Eugeni; Gray, Stephen; Green, Michael; Greenhalgh, Justin; Greenshaw, Timothy; Grefe, Christian; Gregor, Ingrid-Maria; Grenier, Gerald; Grimes, Mark; Grimm, Terry; Gris, Philippe; Grivaz, Jean-Francois; Groll, Marius; Gronberg, Jeffrey; Grondin, Denis; Groom, Donald; Gross, Eilam; Grunewald, Martin; Grupen, Claus; Grzelak, Grzegorz; Gu, Jun; Gu, Yun-Ting; Guchait, Monoranjan; Guiducci, Susanna; Guler, Ali Murat; Guler, Hayg; Gulmez, Erhan; Gunion, John; Guo, Zhi Yu; Gurtu, Atul; Ha, Huy Bang; Haas, Tobias; Haase, Andy; Haba, Naoyuki; Haber, Howard; Haensel, Stephan; Hagge, Lars; Hagura, Hiroyuki; Hajdu, Csaba; Haller, Gunther; Haller, Johannes; Hallermann, Lea; Halyo, Valerie; Hamaguchi, Koichi; Hammond, Larry; Han, Liang; Han, Tao; Hand, Louis; Handu, Virender K.; Hano, Hitoshi; Hansen, Christian; Hansen, Jørn Dines; Hansen, Jorgen Beck; Hara, Kazufumi; Harder, Kristian; Hartin, Anthony; Hartung, Walter; Hast, Carsten; Hauptman, John; Hauschild, Michael; Hauviller, Claude; Havranek, Miroslav; Hawkes, Chris; Hawkings, Richard; Hayano, Hitoshi; Hazumi, Masashi; He, An; He, Hong Jian; Hearty, Christopher; Heath, Helen; Hebbeker, Thomas; Hedberg, Vincent; Hedin, David; Heifets, Samuel; Heinemeyer, Sven; Heini, Sebastien; Helebrant, Christian; Helms, Richard; Heltsley, Brian; Henrot-Versille, Sophie; Henschel, Hans; Hensel, Carsten; Hermel, Richard; Herms, Atilà; Herten, Gregor; Hesselbach, Stefan; Heuer, Rolf-Dieter; Heusch, Clemens A.; Hewett, Joanne; Higashi, Norio; Higashi, Takatoshi; Higashi, Yasuo; Higo, Toshiyasu; Hildreth, Michael D.; Hiller, Karlheinz; Hillert, Sonja; Hillier, Stephen James; Himel, Thomas; Himmi, Abdelkader; Hinchliffe, Ian; Hioki, Zenro; Hirano, Koichiro; Hirose, Tachishige; Hisamatsu, Hiromi; Hisano, Junji; Hlaing, Chit Thu; Hock, Kai Meng; Hoeferkamp, Martin; Hohlfeld, Mark; Honda, Yousuke; Hong, Juho; Hong, Tae Min; Honma, Hiroyuki; Horii, Yasuyuki; Horvath, Dezso; Hosoyama, Kenji; Hostachy, Jean-Yves; Hou, Mi; Hou, Wei-Shu; Howell, David; Hronek, Maxine; Hsiung, Yee B.; Hu, Bo; Hu, Tao; Huang, Jung-Yun; Huang, Tong Ming; Huang, Wen Hui; Huedem, Emil; Huggard, Peter; Hugonie, Cyril; Hu-Guo, Christine; Huitu, Katri; Hwang, Youngseok; Idzik, Marek; Ignatenko, Alexandr; Ignatov, Fedor; Ikeda, Hirokazu; Ikematsu, Katsumasa; Ilicheva, Tatiana; Imbault, Didier; Imhof, Andreas; Incagli, Marco; Ingbir, Ronen; Inoue, Hitoshi; Inoue, Youichi; Introzzi, Gianluca; Ioakeimidi, Katerina; Ishihara, Satoshi; Ishikawa, Akimasa; Ishikawa, Tadashi; Issakov, Vladimir; Ito, Kazutoshi; Ivanov, V.V.; Ivanov, Valentin; Ivanyushenkov, Yury; Iwasaki, Masako; Iwashita, Yoshihisa; Jackson, David; Jackson, Frank; Jacobsen, Bob; Jaganathan, Ramaswamy; Jamison, Steven; Janssen, Matthias Enno; Jaramillo-Echeverria, Richard; Jaros, John; Jauffret, Clement; Jawale, Suresh B.; Jeans, Daniel; Jedziniak, Ron; Jeffery, Ben; Jehanno, Didier; Jenner, Leo J.; Jensen, Chris; Jensen, David R.; Jiang, Hairong; Jiang, Xiao Ming; Jimbo, Masato; Jin, Shan; Keith Jobe, R.; Johnson, Anthony; Johnson, Erik; Johnson, Matt; Johnston, Michael; Joireman, Paul; Jokic, Stevan; Jones, James; Jones, Roger M.; Jongewaard, Erik; Jönsson, Leif; Joshi, Gopal; Joshi, Satish C.; Jung, Jin-Young; Junk, Thomas; Juste, Aurelio; Kado, Marumi; Kadyk, John; Käfer, Daniela; Kako, Eiji; Kalavase, Puneeth; Kalinin, Alexander; Kalinowski, Jan; Kamitani, Takuya; Kamiya, Yoshio; Kamiya, Yukihide; Kamoshita, Jun-ichi; Kananov, Sergey; Kanaya, Kazuyuki; Kanazawa, Ken-ichi; Kanemura, Shinya; Kang, Heung-Sik; Kang, Wen; Kanjial, D.; Kapusta, Frédéric; Karataev, Pavel; Karchin, Paul E.; Karlen, Dean; Karyotakis, Yannis; Kashikhin, Vladimir; Kashiwagi, Shigeru; Kasley, Paul; Katagiri, Hiroaki; Kato, Takashi; Kato, Yukihiro; Katzy, Judith; Kaukher, Alexander; Kaur, Manjit; Kawagoe, Kiyotomo; Kawamura, Hiroyuki; Kazakov, Sergei; Kekelidze, V.D.; Keller, Lewis; Kelley, Michael; Kelly, Marc; Kelly, Michael; Kennedy, Kurt; Kephart, Robert; Keung, Justin; Khainovski, Oleg; Khan, Sameen Ahmed; Khare, Prashant; Khovansky, Nikolai; Kiesling, Christian; Kikuchi, Mitsuo; Kilian, Wolfgang; Killenberg, Martin; Kim, Donghee; Kim, Eun San; Kim, Eun-Joo; Kim, Guinyun; Kim, Hongjoo; Kim, Hyoungsuk; Kim, Hyun-Chui; Kim, Jonghoon; Kim, Kwang-Je; Kim, Kyung Sook; Kim, Peter; Kim, Seunghwan; Kim, Shin-Hong; Kim, Sun Kee; Kim, Tae Jeong; Kim, Youngim; Kim, Young-Kee; Kimmitt, Maurice; Kirby, Robert; Kircher, François; Kisielewska, Danuta; Kittel, Olaf; Klanner, Robert; Klebaner, Arkadiy L.; Kleinwort, Claus; Klimkovich, Tatsiana; Klinkby, Esben; Kluth, Stefan; Knecht, Marc; Kneisel, Peter; Ko, In Soo; Ko, Kwok; Kobayashi, Makoto; Kobayashi, Nobuko; Kobel, Michael; Koch, Manuel; Kodys, Peter; Koetz, Uli; Kohrs, Robert; Kojima, Yuuji; Kolanoski, Hermann; Kolodziej, Karol; Kolomensky, Yury G.; Komamiya, Sachio; Kong, Xiang Cheng; Konigsberg, Jacobo; Korbel, Volker; Koscielniak, Shane; Kostromin, Sergey; Kowalewski, Robert; Kraml, Sabine; Krammer, Manfred; Krasnykh, Anatoly; Krautscheid, Thorsten; Krawczyk, Maria; James Krebs, H.; Krempetz, Kurt; Kribs, Graham; Krishnagopal, Srinivas; Kriske, Richard; Kronfeld, Andreas; Kroseberg, Jürgen; Kruchonak, Uladzimir; Kruecker, Dirk; Krüger, Hans; Krumpa, Nicholas A.; Krumshtein, Zinovii; Kuang, Yu Ping; Kubo, Kiyoshi; Kuchler, Vic; Kudoh, Noboru; Kulis, Szymon; Kumada, Masayuki; Kumar, Abhay; Kume, Tatsuya; Kundu, Anirban; Kurevlev, German; Kurihara, Yoshimasa; Kuriki, Masao; Kuroda, Shigeru; Kuroiwa, Hirotoshi; Kurokawa, Shin-ichi; Kusano, Tomonori; Kush, Pradeep K.; Kutschke, Robert; Kuznetsova, Ekaterina; Kvasnicka, Peter; Kwon, Youngjoon; Labarga, Luis; Lacasta, Carlos; Lackey, Sharon; Lackowski, Thomas W.; Lafaye, Remi; Lafferty, George; Lagorio, Eric; Laktineh, Imad; Lal, Shankar; Laloum, Maurice; Lam, Briant; Lancaster, Mark; Lander, Richard; Lange, Wolfgang; Langenfeld, Ulrich; Langeveld, Willem; Larbalestier, David; Larsen, Ray; Lastovicka, Tomas; Lastovicka-Medin, Gordana; Latina, Andrea; Latour, Emmanuel; Laurent, Lisa; Le, Ba Nam; Le, Duc Ninh; Le Diberder, Francois; Dû, Patrick Le; Lebbolo, Hervé; Lebrun, Paul; Lecoq, Jacques; Lee, Sung-Won; Lehner, Frank; Leibfritz, Jerry; Lenkszus, Frank; Lesiak, Tadeusz; Levy, Aharon; Lewandowski, Jim; Leyh, Greg; Li, Cheng; Li, Chong Sheng; Li, Chun Hua; Li, Da Zhang; Li, Gang; Li, Jin; Li, Shao Peng; Li, Wei Ming; Li, Weiguo; Li, Xiao Ping; Li, Xue-Qian; Li, Yuanjing; Li, Yulan; Li, Zenghai; Li, Zhong Quan; Liang, Jian Tao; Liao, Yi; Lilje, Lutz; Guilherme Lima, J.; Lintern, Andrew J.; Lipton, Ronald; List, Benno; List, Jenny; Liu, Chun; Liu, Jian Fei; Liu, Ke Xin; Liu, Li Qiang; Liu, Shao Zhen; Liu, Sheng Guang; Liu, Shubin; Liu, Wanming; Liu, Wei Bin; Liu, Ya Ping; Liu, Yu Dong; Lockyer, Nigel; Logan, Heather E.; Logatchev, Pavel V.; Lohmann, Wolfgang; Lohse, Thomas; Lola, Smaragda; Lopez-Virto, Amparo; Loveridge, Peter; Lozano, Manuel; Lu, Cai-Dian; Lu, Changguo; Lu, Gong-Lu; Lu, Wen Hui; Lubatti, Henry; Lucotte, Arnaud; Lundberg, Björn; Lundin, Tracy; Luo, Mingxing; Luong, Michel; Luth, Vera; Lutz, Benjamin; Lutz, Pierre; Lux, Thorsten; Luzniak, Pawel; Lyapin, Alexey; Lykken, Joseph; Lynch, Clare; Ma, Li; Ma, Lili; Ma, Qiang; Ma, Wen-Gan; Macfarlane, David; Maciel, Arthur; MacLeod, Allan; MacNair, David; Mader, Wolfgang; Magill, Stephen; Magnan, Anne-Marie; Maiheu, Bino; Maity, Manas; Majchrzak, Millicent; Majumder, Gobinda; Makarov, Roman; Makowski, Dariusz; Malaescu, Bogdan; Mallik, C.; Mallik, Usha; Malton, Stephen; Malyshev, Oleg B.; Malysheva, Larisa I.; Mammosser, John; Mamta; Mamuzic, Judita; Manen, Samuel; Manghisoni, Massimo; Manly, Steven; Marcellini, Fabio; Marcisovsky, Michal; Markiewicz, Thomas W.; Marks, Steve; Marone, Andrew; Marti, Felix; Martin, Jean-Pierre; Martin, Victoria; Martin-Chassard, Gisèle; Martinez, Manel; Martinez-Rivero, Celso; Martsch, Dennis; Martyn, Hans-Ulrich; Maruyama, Takashi; Masuzawa, Mika; Mathez, Hervé; Matsuda, Takeshi; Matsumoto, Hiroshi; Matsumoto, Shuji; Matsumoto, Toshihiro; Matsunaga, Hiroyuki; Mättig, Peter; Mattison, Thomas; Mavromanolakis, Georgios; Mawatari, Kentarou; Mazzacane, Anna; McBride, Patricia; McCormick, Douglas; McCormick, Jeremy; McDonald, Kirk T.; McGee, Mike; McIntosh, Peter; McKee, Bobby; McPherson, Robert A.; Meidlinger, Mandi; Meier, Karlheinz; Mele, Barbara; Meller, Bob; Melzer-Pellmann, Isabell-Alissandra; Mendez, Hector; Mercer, Adam; Merkin, Mikhail; Meshkov, I.N.; Messner, Robert; Metcalfe, Jessica; Meyer, Chris; Meyer, Hendrik; Meyer, Joachim; Meyer, Niels; Meyners, Norbert; Michelato, Paolo; Michizono, Shinichiro; Mihalcea, Daniel; Mihara, Satoshi; Mihara, Takanori; Mikami, Yoshinari; Mikhailichenko, Alexander A.; Milardi, Catia; Miller, David J.; Miller, Owen; Miller, Roger J.; Milstene, Caroline; Mimashi, Toshihiro; Minashvili, Irakli; Miquel, Ramon; Mishra, Shekhar; Mitaroff, Winfried; Mitchell, Chad; Miura, Takako; Miyamoto, Akiya; Miyata, Hitoshi; Mjörnmark, Ulf; Mnich, Joachim; Moenig, Klaus; Moffeit, Kenneth; Mokhov, Nikolai; Molloy, Stephen; Monaco, Laura; Monasterio, Paul R.; Montanari, Alessandro; Moon, Sung Ik; Moortgat-Pick, Gudrid A.; Mora de Freitas, Paulo; Morel, Federic; Moretti, Stefano; Morgunov, Vasily; Mori, Toshinori; Morin, Laurent; Morisseau, François; Morita, Yoshiyuki; Morita, Youhei; Morita, Yuichi; Morozov, Nikolai; Morozumi, Yuichi; Morse, William; Moser, Hans-Guenther; Moultaka, Gilbert; Mtingwa, Sekazi; Mudrinic, Mihajlo; Mueller, Alex; Mueller, Wolfgang; Muennich, Astrid; Muhlleitner, Milada Margarete; Mukherjee, Bhaskar; Mukhopadhyaya, Biswarup; Müller, Thomas; Munro, Morrison; Murayama, Hitoshi; Muto, Toshiya; Myneni, Ganapati Rao; Nabhiraj, P.Y.; Nagaitsev, Sergei; Nagamine, Tadashi; Nagano, Ai; Naito, Takashi; Nakai, Hirotaka; Nakajima, Hiromitsu; Nakamura, Isamu; Nakamura, Tomoya; Nakanishi, Tsutomu; Nakao, Katsumi; Nakao, Noriaki; Nakayoshi, Kazuo; Nam, Sang; Namito, Yoshihito; Namkung, Won; Nantista, Chris; Napoly, Olivier; Narain, Meenakshi; Naroska, Beate; Nauenberg, Uriel; Nayyar, Ruchika; Neal, Homer; Nelson, Charles; Nelson, Janice; Nelson, Timothy; Nemecek, Stanislav; Neubauer, Michael; Neuffer, David; Newman, Myriam Q.; Nezhevenko, Oleg; Ng, Cho-Kuen; Nguyen, Anh Ky; Nguyen, Minh; Van Nguyen Thi,Hong; Niebuhr, Carsten; Niehoff, Jim; Niezurawski, Piotr; Nishitani, Tomohiro; Nitoh, Osamu; Noguchi, Shuichi; Nomerotski, Andrei; Noonan, John; Norbeck, Edward; Nosochkov, Yuri; Notz, Dieter; Nowak, Grazyna; Nowak, Hannelies; Noy, Matthew; Nozaki, Mitsuaki; Nyffeler, Andreas; Nygren, David; Oddone, Piermaria; O'Dell, Joseph; Oh, Jong-Seok; Oh, Sun Kun; Ohkuma, Kazumasa; Ohlerich, Martin; Ohmi, Kazuhito; Ohnishi, Yukiyoshi; Ohsawa, Satoshi; Ohuchi, Norihito; Oide, Katsunobu; Okada, Nobuchika; Okamura, Takahiro; Okugi, Toshiyuki; Okumi, Shoji; Okumura, Ken-ichi; Olchevski, Alexander; Oliver, William; Olivier, Bob; Olsen, James; Olsen, Jeff; Olsen, Stephen; Olshevsky, A.G.; Olsson, Jan; Omori, Tsunehiko; Onel, Yasar; Onengut, Gulsen; Ono, Hiroaki; Onoprienko, Dmitry; Oreglia, Mark; Oren, Will; Orimoto, Toyoko J.; Oriunno, Marco; Orlandea, Marius Ciprian; Oroku, Masahiro; Orr, Lynne H.; Orr, Robert S.; Oshea, Val; Oskarsson, Anders; Osland, Per; Ossetski, Dmitri; Österman, Lennart; Ostiguy, Francois; Otono, Hidetoshi; Ottewell, Brian; Ouyang, Qun; Padamsee, Hasan; Padilla, Cristobal; Pagani, Carlo; Palmer, Mark A.; Pam, Wei Min; Pande, Manjiri; Pande, Rajni; Pandit, V.S.; Pandita, P.N.; Pandurovic, Mila; Pankov, Alexander; Panzeri, Nicola; Papandreou, Zisis; Paparella, Rocco; Para, Adam; Park, Hwanbae; Parker, Brett; Parkes, Chris; Parma, Vittorio; Parsa, Zohreh; Parsons, Justin; Partridge, Richard; Pasquinelli, Ralph; Pásztor, Gabriella; Paterson, Ewan; Patrick, Jim; Patteri, Piero; Ritchie Patterson, J.; Pauletta, Giovanni; Paver, Nello; Pavlicek, Vince; Pawlik, Bogdan; Payet, Jacques; Pchalek, Norbert; Pedersen, John; Pei, Guo Xi; Pei, Shi Lun; Pelka, Jerzy; Pellegrini, Giulio; Pellett, David; Peng, G.X.; Penn, Gregory; Penzo, Aldo; Perry, Colin; Peskin, Michael; Peters, Franz; Petersen, Troels Christian; Peterson, Daniel; Peterson, Thomas; Petterson, Maureen; Pfeffer, Howard; Pfund, Phil; Phelps, Alan; Van Phi, Quang; Phillips, Jonathan; Phinney, Nan; Piccolo, Marcello; Piemontese, Livio; Pierini, Paolo; Thomas Piggott, W.; Pike, Gary; Pillet, Nicolas; Jayawardena, Talini Pinto; Piot, Phillippe; Pitts, Kevin; Pivi, Mauro; Plate, Dave; Pleier, Marc-Andre; Poblaguev, Andrei; Poehler, Michael; Poelker, Matthew; Poffenberger, Paul; Pogorelsky, Igor; Poirier, Freddy; Poling, Ronald; Poole, Mike; Popescu, Sorina; Popielarski, John; Pöschl, Roman; Postranecky, Martin; Potukochi, Prakash N.; Prast, Julie; Prat, Serge; Preger, Miro; Prepost, Richard; Price, Michael; Proch, Dieter; Puntambekar, Avinash; Qin, Qing; Qu, Hua Min; Quadt, Arnulf; Quesnel, Jean-Pierre; Radeka, Veljko; Rahmat, Rahmat; Rai, Santosh Kumar; Raimondi, Pantaleo; Ramberg, Erik; Ranjan, Kirti; Rao, Sista V.L.S.; Raspereza, Alexei; Ratti, Alessandro; Ratti, Lodovico; Raubenheimer, Tor; Raux, Ludovic; Ravindran, V.; Raychaudhuri, Sreerup; Re, Valerio; Rease, Bill; Reece, Charles E.; Regler, Meinhard; Rehlich, Kay; Reichel, Ina; Reichold, Armin; Reid, John; Reid, Ron; Reidy, James; Reinhard, Marcel; Renz, Uwe; Repond, Jose; Resta-Lopez, Javier; Reuen, Lars; Ribnik, Jacob; Rice, Tyler; Richard, François; Riemann, Sabine; Riemann, Tord; Riles, Keith; Riley, Daniel; Rimbault, Cécile; Rindani, Saurabh; Rinolfi, Louis; Risigo, Fabio; Riu, Imma; Rizhikov, Dmitri; Rizzo, Thomas; Rochford, James H.; Rodriguez, Ponciano; Roeben, Martin; Rolandi, Gigi; Roodman, Aaron; Rosenberg, Eli; Roser, Robert; Ross, Marc; Rossel, François; Rossmanith, Robert; Roth, Stefan; Rougé, André; Rowe, Allan; Roy, Amit; Roy, Sendhunil B.; Roy, Sourov; Royer, Laurent; Royole-Degieux, Perrine; Royon, Christophe; Ruan, Manqi; Rubin, David; Ruehl, Ingo; Jimeno, Alberto Ruiz; Ruland, Robert; Rusnak, Brian; Ryu, Sun-Young; Sabbi, Gian Luca; Sadeh, Iftach; Sadygov, Ziraddin Y; Saeki, Takayuki; Sagan, David; Sahni, Vinod C.; Saini, Arun; Saito, Kenji; Saito, Kiwamu; Sajot, Gerard; Sakanaka, Shogo; Sakaue, Kazuyuki; Salata, Zen; Salih, Sabah; Salvatore, Fabrizio; Samson, Joergen; Sanami, Toshiya; Levi Sanchez, Allister; Sands, William; Santic, John; Sanuki, Tomoyuki; Sapronov, Andrey; Sarkar, Utpal; Sasao, Noboru; Satoh, Kotaro; Sauli, Fabio; Saunders, Claude; Saveliev, Valeri; Savoy-Navarro, Aurore; Sawyer, Lee; Saxton, Laura; Schäfer, Oliver; Schälicke, Andreas; Schade, Peter; Schaetzel, Sebastien; Scheitrum, Glenn; Schibler, Emilie; Schindler, Rafe; Schlösser, Markus; Schlueter, Ross D.; Schmid, Peter; Schmidt, Ringo Sebastian; Schneekloth, Uwe; Schreiber, Heinz Juergen; Schreiber, Siegfried; Schroeder, Henning; Peter Schüler, K.; Schulte, Daniel; Schultz-Coulon, Hans-Christian; Schumacher, Markus; Schumann, Steffen; Schumm, Bruce A.; Schwienhorst, Reinhard; Schwierz, Rainer; Scott, Duncan J.; Scuri, Fabrizio; Sefkow, Felix; Sefri, Rachid; Seguin-Moreau, Nathalie; Seidel, Sally; Seidman, David; Sekmen, Sezen; Seletskiy, Sergei; Senaha, Eibun; Senanayake, Rohan; Sendai, Hiroshi; Sertore, Daniele; Seryi, Andrei; Settles, Ronald; Sever, Ramazan; Shales, Nicholas; Shao, Ming; Shelkov, G.A.; Shepard, Ken; Shepherd-Themistocleous, Claire; Sheppard, John C.; Shi, Cai Tu; Shidara, Tetsuo; Shim, Yeo-Jeong; Shimizu, Hirotaka; Shimizu, Yasuhiro; Shimizu, Yuuki; Shimogawa, Tetsushi; Shin, Seunghwan; Shioden, Masaomi; Shipsey, Ian; Shirkov, Grigori; Shishido, Toshio; Shivpuri, Ram K.; Shrivastava, Purushottam; Shulga, Sergey; Shumeiko, Nikolai; Shuvalov, Sergey; Si, Zongguo; Siddiqui, Azher Majid; Siegrist, James; Simon, Claire; Simrock, Stefan; Sinev, Nikolai; Singh, Bhartendu K.; Singh, Jasbir; Singh, Pitamber; Singh, R.K.; Singh, S.K.; Singini, Monito; Sinha, Anil K.; Sinha, Nita; Sinha, Rahul; Sinram, Klaus; Sissakian, A.N.; Skachkov, N.B.; Skrinsky, Alexander; Slater, Mark; Slominski, Wojciech; Smiljanic, Ivan; Smith, A J Stewart; Smith, Alex; Smith, Brian J.; Smith, Jeff; Smith, Jonathan; Smith, Steve; Smith, Susan; Smith, Tonee; Neville Snodgrass, W.; Sobloher, Blanka; Sohn, Young-Uk; Solidum, Ruelson; Solyak, Nikolai; Son, Dongchul; Sonmez, Nasuf; Sopczak, Andre; Soskov, V.; Spencer, Cherrill M.; Spentzouris, Panagiotis; Speziali, Valeria; Spira, Michael; Sprehn, Daryl; Sridhar, K.; Srivastava, Asutosh; St. Lorant, Steve; Stahl, Achim; Stanek, Richard P.; Stanitzki, Marcel; Stanley, Jacob; Stefanov, Konstantin; Stein, Werner; Steiner, Herbert; Stenlund, Evert; Stern, Amir; Sternberg, Matt; Stockinger, Dominik; Stockton, Mark; Stoeck, Holger; Strachan, John; Strakhovenko, V.; Strauss, Michael; Striganov, Sergei I.; Strologas, John; Strom, David; Strube, Jan; Stupakov, Gennady; Su, Dong; Sudo, Yuji; Suehara, Taikan; Suehiro, Toru; Suetsugu, Yusuke; Sugahara, Ryuhei; Sugimoto, Yasuhiro; Sugiyama, Akira; Suh, Jun Suhk; Sukovic, Goran; Sun, Hong; Sun, Stephen; Sun, Werner; Sun, Yi; Sun, Yipeng; Suszycki, Leszek; Sutcliffe, Peter; Suthar, Rameshwar L.; Suwada, Tsuyoshi; Suzuki, Atsuto; Suzuki, Chihiro; Suzuki, Shiro; Suzuki, Takashi; Swent, Richard; Swientek, Krzysztof; Swinson, Christina; Syresin, Evgeny; Szleper, Michal; Tadday, Alexander; Takahashi, Rika; Takahashi, Tohru; Takano, Mikio; Takasaki, Fumihiko; Takeda, Seishi; Takenaka, Tateru; Takeshita, Tohru; Takubo, Yosuke; Tanaka, Masami; Tang, Chuan Xiang; Taniguchi, Takashi; Tantawi, Sami; Tapprogge, Stefan; Tartaglia, Michael A.; Tassielli, Giovanni Francesco; Tauchi, Toshiaki; Tavian, Laurent; Tawara, Hiroko; Taylor, Geoffrey; Telnov, Alexandre V.; Telnov, Valery; Tenenbaum, Peter; Teodorescu, Eliza; Terashima, Akio; Terracciano, Giuseppina; Terunuma, Nobuhiro; Teubner, Thomas; Teuscher, Richard; Theilacker, Jay; Thomson, Mark; Tice, Jeff; Tigner, Maury; Timmermans, Jan; Titov, Maxim; Toge, Nobukazu; Tokareva, N.A.; Tollefson, Kirsten; Tomasek, Lukas; Tomovic, Savo; Tompkins, John; Tonutti, Manfred; Topkar, Anita; Toprek, Dragan; Toral, Fernando; Torrence, Eric; Traversi, Gianluca; Trimpl, Marcel; Mani Tripathi, S.; Trischuk, William; Trodden, Mark; Trubnikov, G.V.; Tschirhart, Robert; Tskhadadze, Edisher; Tsuchiya, Kiyosumi; Tsukamoto, Toshifumi; Tsunemi, Akira; Tucker, Robin; Turchetta, Renato; Tyndel, Mike; Uekusa, Nobuhiro; Ueno, Kenji; Umemori, Kensei; Ummenhofer, Martin; Underwood, David; Uozumi, Satoru; Urakawa, Junji; Urban, Jeremy; Uriot, Didier; Urner, David; Ushakov, Andrei; Usher, Tracy; Uzunyan, Sergey; Vachon, Brigitte; Valerio, Linda; Valin, Isabelle; Valishev, Alex; Vamra, Raghava; Van der Graaf, Harry; Van Kooten, Rick; Van Zandbergen, Gary; Vanel, Jean-Charles; Variola, Alessandro; Varner, Gary; Velasco, Mayda; Velte, Ulrich; Velthuis, Jaap; Vempati, Sundir K.; Venturini, Marco; Vescovi, Christophe; Videau, Henri; Vila, Ivan; Vincent, Pascal; Virey, Jean-Marc; Visentin, Bernard; Viti, Michele; Vo, Thanh Cuong; Vogel, Adrian; Vogt, Harald; von Toerne, Eckhard; Vorozhtsov, S.B.; Vos, Marcel; Votava, Margaret; Vrba, Vaclav; Wackeroth, Doreen; Wagner, Albrecht; Wagner, Carlos E.M.; Wagner, Stephen; Wake, Masayoshi; Walczak, Roman; Walkowiak, Wolfgang; Wallon, Samuel; Walsh, Roberval; Walston, Sean; Waltenberger, Wolfgang; Walz, Dieter; Wang, Chao En; Wang, Chun Hong; Wang, Dou; Wang, Faya; Wang, Guang Wei; Wang, Haitao; Wang, Jiang; Wang, Jiu Qing; Wang, Juwen; Wang, Lanfa; Wang, Lei; Wang, Min-Zu; Wang, Qing; Wang, Shu Hong; Wang, Xiaolian; Wang, Xue-Lei; Wang, Yi Fang; Wang, Zheng; Wanzenberg, Rainer; Ward, Bennie; Ward, David; Warmbein, Barbara; Warner, David W.; Warren, Matthew; Washio, Masakazu; Watanabe, Isamu; Watanabe, Ken; Watanabe, Takashi; Watanabe, Yuichi; Watson, Nigel; Wattimena, Nanda; Wayne, Mitchell; Weber, Marc; Weerts, Harry; Weiglein, Georg; Weiland, Thomas; Weinzierl, Stefan; Weise, Hans; Weisend, John; Wendt, Manfred; Wendt, Oliver; Wenzel, Hans; Wenzel, William A.; Wermes, Norbert; Werthenbach, Ulrich; Wesseln, Steve; Wester, William; White, Andy; White, Glen R.; Wichmann, Katarzyna; Wienemann, Peter; Wierba, Wojciech; Wilksen, Tim; Willis, William; Wilson, Graham W.; Wilson, John A.; Wilson, Robert; Wing, Matthew; Winter, Marc; Wirth, Brian D.; Wolbers, Stephen A.; Wolff, Dan; Wolski, Andrzej; Woodley, Mark D.; Woods, Michael; Woodward, Michael L.; Woolliscroft, Timothy; Worm, Steven; Wormser, Guy; Wright, Dennis; Wright, Douglas; Wu, Andy; Wu, Tao; Wu, Yue Liang; Xella, Stefania; Xia, Guoxing; Xia, Lei; Xiao, Aimin; Xiao, Liling; Xie, Jia Lin; Xing, Zhi-Zhong; Xiong, Lian You; Xu, Gang; Xu, Qing Jing; Yajnik, Urjit A.; Yakimenko, Vitaly; Yamada, Ryuji; Yamaguchi, Hiroshi; Yamamoto, Akira; Yamamoto, Hitoshi; Yamamoto, Masahiro; Yamamoto, Naoto; Yamamoto, Richard; Yamamoto, Yasuchika; Yamanaka, Takashi; Yamaoka, Hiroshi; Yamashita, Satoru; Yamazaki, Hideki; Yan, Wenbiao; Yang, Hai-Jun; Yang, Jin Min; Yang, Jongmann; Yang, Zhenwei; Yano, Yoshiharu; Yazgan, Efe; Yeh, G.P.; Yilmaz, Hakan; Yock, Philip; Yoda, Hakutaro; Yoh, John; Yokoya, Kaoru; Yokoyama, Hirokazu; York, Richard C.; Yoshida, Mitsuhiro; Yoshida, Takuo; Yoshioka, Tamaki; Young, Andrew; Yu, Cheng Hui; Yu, Jaehoon; Yu, Xian Ming; Yuan, Changzheng; Yue, Chong-Xing; Yue, Jun Hui; Zacek, Josef; Zagorodnov, Igor; Zalesak, Jaroslav; Zalikhanov, Boris; Zarnecki, Aleksander Filip; Zawiejski, Leszek; Zeitnitz, Christian; Zeller, Michael; Zerwas, Dirk; Zerwas, Peter; Zeyrek, Mehmet; Zhai, Ji Yuan; Zhang, Bao Cheng; Zhang, Bin; Zhang, Chuang; Zhang, He; Zhang, Jiawen; Zhang, Jing; Zhang, Jing Ru; Zhang, Jinlong; Zhang, Liang; Zhang, X.; Zhang, Yuan; Zhang, Zhige; Zhang, Zhiqing; Zhang, Ziping; Zhao, Haiwen; Zhao, Ji Jiu; Zhao, Jing Xia; Zhao, Ming Hua; Zhao, Sheng Chu; Zhao, Tianchi; Zhao, Tong Xian; Zhao, Zhen Tang; Zhao, Zhengguo; Zhou, De Min; Zhou, Feng; Zhou, Shun; Zhu, Shou Hua; Zhu, Xiong Wei; Zhukov, Valery; Zimmermann, Frank; Ziolkowski, Michael; Zisman, Michael S.; Zomer, Fabian; Zong, Zhang Guo; Zorba, Osman; Zutshi, Vishnu

2007-01-01

The International Linear Collider (ILC) is a 200-500 GeV center-of-mass high-luminosity linear electron-positron collider, based on 1.3 GHz superconducting radio-frequency (SCRF) accelerating cavities. The ILC has a total footprint of about 31 km and is designed for a peak luminosity of 2x10^34 cm^-2s^-1. This report is the Executive Summary (Volume I) of the four volume Reference Design Report. It gives an overview of the physics at the ILC, the accelerator design and value estimate, the detector concepts, and the next steps towards project realization.

GC Method Validation for the Analysis of Menthol in Suppository Pharmaceutical Dosage Form

Directory of Open Access Journals (Sweden)

Murad N. Abualhasan

2017-01-01

Full Text Available Menthol is widely used as a fragrance and flavor in the food and cosmetic industries. It is also used in the medical and pharmaceutical fields for its various biological effects. Gas chromatography (GC is considered to be a sensitive method for the analysis of menthol. GC chromatographic separation was developed using capillary column (VF-624 and a flame ionization detector (FID. The method was validated as per ICH guidelines for various parameters such as precision, linearity, accuracy, solution stability, robustness, limit of detection, and quantification. The tested validation parameters were found to be within acceptable limits. The method was successfully applied for the quantification of menthol in suppositories formulations. Quality control departments and official pharmacopeias can use our developed method in the analysis of menthol in pharmaceutical dosage formulation and raw material.

How the industry is marketing menthol cigarettes: the audience, the message and the medium.

Science.gov (United States)

Richardson, Amanda; Ganz, Ollie; Pearson, Jennifer; Celcis, Nathalie; Vallone, Donna; Villanti, Andrea C

2015-11-01

Despite declines in overall US cigarette consumption, the menthol cigarette market share has increased in recent years. Advertising contributes to menthol initiation and use, but little has been done to characterise menthol cigarette advertising outside of the point of sale. Two full-service advertising firms were used to develop a library of menthol cigarette advertisements (ads) over a 9-month period (June 2012-February 2013) in the USA. The volume of ads, media channel (direct mail, print, online, email), estimated spend and households reached was summarised overall and by brand in 2013. Direct mail, email and print ads were coded for content and the target audience of print publications was examined. Over the study period, 205 menthol cigarette ads were identified with estimated expenditures exceeding US$31 million, with 70% spent on direct mail ads. Over 90% of ads promoted Camel, Marlboro and Newport menthol cigarettes. A majority (87%) of direct mail ads contained coupons or other incentives known to appeal to price-sensitive customers. Only two brands' print ads appeared during this period: Newport ads focused on themes of sociability and sexuality, and were placed in magazines targeting African-Americans and younger consumers; American Spirit print ads were placed in general interest magazines and predominantly stressed the 'natural' aspects of their brand. The tobacco industry continues to spend millions of dollars promoting menthol cigarettes through channels that preferentially target vulnerable subgroups, such as African-Americans and younger consumers. Public health campaigns to educate and combat the influence of menthol advertising are needed. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Synthesis of optically active α-Methylstyrene-N- phenyl maleamic acid copolymer via asymmetric induction by 1-menthol

International Nuclear Information System (INIS)

Khettab, F. A.; Korshid, C. A.

1998-01-01

Copolymerization of α-methylstyrene with N-phenyl maleamic acid was studied in the presence and absence of 1-menthol, using 2,2 ' - azobis (isobutyronitrils) AIBN as initiator in toluene. The optically active copolymer is formed by the addition of 1-menthol of the copolymerization system. The observed optical activity is presumed to be due to asymmetry induced in the backbone of the copolymer by the chirality of 1-menthol. The influence of 1-menthol is considered to be caused by an electrostatic interaction between N-phenyl maleamic acid and the polar group of 1-menthol. (author). 9 refs., 1 fig., 4 tabs

Executive summary of European Task Force document on diagnostic tools in rhinology

NARCIS (Netherlands)

Hellings, P. W.; Scadding, G.; Alobid, I.; Bachert, C.; Fokkens, W. J.; Gerth van Wijk, R.; Gevaerts, P.; Guilemany, J.; Kalogjera, L.; Lund, V. J.; Mullol, J.; Passalacqua, G.; Toskala, E.; van Drunen, C. M.

2012-01-01

This Executive Summary of the EAACI Task Force document on Diagnostic Tools in Rhinology provides the readers with an over- view of the currently available tools for diagnosis of nasal and sino-nasal disease, published in full version in the first issue of Clini- cal and Translational Allergy. A

HEAO Block 2 study executive summary

International Nuclear Information System (INIS)

1976-03-01

An executive summary is presented of a preliminary study done on several potential High Energy Astronomy Observatory (HEAO) missions which are follow-on missions to the currently defined HEAO program. The purpose was to examine several typical missions and determine the relative complexities associated with them. The four payloads investigated were a 1.2 m Diameter x-ray Telescope observatory, a Large Area Moderate Angular Resolution (LAMAR) observatory, a cosmic ray observatory, and (4) a gamma ray observatory. Each of the four observatories was considered a national facility. Low cost approaches were stressed throughout, with considerable use of HEAO Block I experience and designs effected to provide a high degree of confidence that such approaches were achievable. The use of the Multi-Mission Spacecraft (MMS) and the HEAO Block I spacecraft was considered as a result of this low cost emphasis. Also, NASA standard components were considered, where applicable

Menthol cigarette pricing at military and community retail outlets in the United States.

Science.gov (United States)

Poston, Walker S C; Jahnke, Sara A; Haddock, Christopher K; Hyder, Melissa L; Taylor, Jennifer E; Lando, Harry A; Kaipust, Christopher M

2012-09-01

Cigarette prices at military exchanges historically have been discounted. DoD Instruction 1330.9 has mandated that prices be within 5% of the price offered in the local community since 2001. Because minorities are highly represented in the military, we determined whether menthol cigarette prices, the leading choice of African Americans, were compliant with the instruction. We collected, via telephone, menthol cigarette price data from 48 randomly selected US military installation exchanges and matched local area Walmarts. We collected prices after taxes to determine the cost to consumer. Newport was selected as the index brand for menthol cigarettes because it is the leading and second leading brand smoked by African Americans and by Hispanics, respectively and has the second overall highest market share in the US. Smokers purchasing menthols at exchanges would realize average savings of 22.78%. There were no significant differences in savings based on military service (F = 1.850, p = 0.152) or US Census Division (F = 1.226, p = 0.311: data not shown). In addition, not a single exchange price was compliant with the DoD instruction. Newport menthol cigarettes at military exchanges cost substantially less than the nearest Walmart, with an average savings of 23%. Our findings demonstrate that menthol cigarettes are substantially discounted on military installations, in a manner similar to other cigarette prices, and that DoD Instruction 1330.09 is not enforced.

Menthol cigarette pricing at military and community retail outlets in the United States

Directory of Open Access Journals (Sweden)

Poston Walker SC

2012-09-01

Full Text Available Abstract Background Cigarette prices at military exchanges historically have been discounted. DoD Instruction 1330.9 has mandated that prices be within 5% of the price offered in the local community since 2001. Because minorities are highly represented in the military, we determined whether menthol cigarette prices, the leading choice of African Americans, were compliant with the instruction. Methods We collected, via telephone, menthol cigarette price data from 48 randomly selected US military installation exchanges and matched local area Walmarts. We collected prices after taxes to determine the cost to consumer. Newport was selected as the index brand for menthol cigarettes because it is the leading and second leading brand smoked by African Americans and by Hispanics, respectively and has the second overall highest market share in the US. Results Smokers purchasing menthols at exchanges would realize average savings of 22.78%. There were no significant differences in savings based on military service (F = 1.850, p = 0.152 or US Census Division (F = 1.226, p = 0.311: data not shown. In addition, not a single exchange price was compliant with the DoD instruction. Conclusions Newport menthol cigarettes at military exchanges cost substantially less than the nearest Walmart, with an average savings of 23%. Our findings demonstrate that menthol cigarettes are substantially discounted on military installations, in a manner similar to other cigarette prices, and that DoD Instruction 1330.09 is not enforced.

Reviving the Rural Factory: Automation and Work in the South. Executive Summary.

Science.gov (United States)

Rosenfeld, Stuart A.; And Others

This document is the executive summary for a two volume report on technological innovation and southern rural industrial development. The first volume examines public and private factors that influence investment decisions in new technologies and the outcomes of those decisions; effects of automation on employment and the workplace; outcomes of…

Physiological and biochemical performances of menthol-induced aposymbiotic corals.

Directory of Open Access Journals (Sweden)

Jih-Terng Wang

Full Text Available The unique mutualism between corals and their photosynthetic zooxanthellae (Symbiodinium spp. is the driving force behind functional assemblages of coral reefs. However, the respective roles of hosts and Symbiodinium in this endosymbiotic association, particularly in response to environmental challenges (e.g., high sea surface temperatures, remain unsettled. One of the key obstacles is to produce and maintain aposymbiotic coral hosts for experimental purposes. In this study, a simple and gentle protocol to generate aposymbiotic coral hosts (Isopora palifera and Stylophora pistillata was developed using repeated incubation in menthol/artificial seawater (ASW medium under light and in ASW in darkness, which depleted more than 99% of Symbiodinium from the host within 4∼8 days. As indicated by the respiration rate, energy metabolism (by malate dehydrogenase activity, and nitrogen metabolism (by glutamate dehydrogenase activity and profiles of free amino acids, the physiological and biochemical performances of the menthol-induced aposymbiotic corals were comparable to their symbiotic counterparts without nutrient supplementation (e.g., for Stylophora or with a nutrient supplement containing glycerol, vitamins, and a host mimic of free amino acid mixture (e.g., for Isopora. Differences in biochemical responses to menthol-induced bleaching between Stylophora and Isopora were attributed to the former digesting Symbiodinium rather than expelling the algae live as found in the latter species. Our studies showed that menthol could successfully bleach corals and provided aposymbiotic corals for further exploration of coral-alga symbioses.

Southeastern Regional Geologic Characterization Report. Executive summary. Final report

International Nuclear Information System (INIS)

1985-08-01

This Executive Summary of the final Southeastern Regional Geologic Characterization Report (RGCR) is issued primarily for public information purposes, and provides a general overview of the report. The complete RGCR presents available regional geologic information pertinent to siting a repository for high-level nuclear waste in crystalline rock in central Maryland; noncoastal Virginia, North Carolina, and South Carolina; and northern Georgia. For each of the states within the Southeastern Region, information is provided on the geologic disqualifying factor and the geologic regional screening variables to be used in region-to-area screening

Northeastern Regional Environmental Characterization Report. Executive summary. Final report

International Nuclear Information System (INIS)

1985-08-01

This Executive Summary of the final Northeastern Regional Environmental Characterization Report (RECR) is issued primarily for public information purposes and provides a general overview of the report. The complete RECR presents available regional environmental information pertinent to siting a repository for high-level nuclear waste in crystalline rock in Connecticut, Maine, Massachusetts, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, and Vermont. For each of the states within the Northeastern Region, information is provided on the environmental disqualifying factors and the environmental regional screening variables to be used in region-to-area screening

North Central regional environmental characterization report: executive summary - final

International Nuclear Information System (INIS)

1985-08-01

This Executive Summary of the final North Central Regional Environmental Characterization Report (RECR) is issued primarily for public information purposes and provides a general overview of the report. The complete RECR presents available regional environmental information pertinent to siting a repository for high-level nuclear waste in crystalline rock in Minnesota, Wisconsin, and the Upper Peninsula of Michigan. For each of the States within the North Central Region, information is provided on the environmental disqualifying factors and the environmental regional screening variables to be used in region-to-area screening

Southeastern Regional Environmental Characterization Report: executive summary. Final report

International Nuclear Information System (INIS)

1985-08-01

This Executive Summary of the final ''Southeastern Regional Environmental Characterization Report'' (RECR) is issued primarily for public information purposes and provides a general overview of the report. The complete RECR presents available regional environmental information pertinent to siting a repository or high-level nuclear waste in crystalline rock in central Maryland; noncoastal Virginia, North Carolina, and South Carolina; and northern Georgia. For each of the states within the Southeastern Region, information is provided on the environmental disqualifying factors and the environmental regional screening variables to be used in region-to-area screening

Disparities and menthol marketing: additional evidence in support of point of sale policies.

Science.gov (United States)

Moreland-Russell, Sarah; Harris, Jenine; Snider, Doneisha; Walsh, Heidi; Cyr, Julianne; Barnoya, Joaquin

2013-09-25

This study examined factors associated with point-of-sale tobacco marketing in St. Louis, an urban city in the United States. Using spatial analysis, descriptive statistics, and multilevel modeling, we examined point-of-sale data and the proportion of mentholated cigarette and total cigarette marketing from 342 individual tobacco retail stores within St. Louis census tracts characterized by the percent of black adults and children. Menthol and total tobacco product marketing was highest in areas with the highest percentages of black residents. When examining menthol marketing to children, we did not find as strong of a relationship, however results of multilevel modeling indicate that as the proportion of black children in a census tract increased, the proportion of menthol marketing near candy also increased. These results indicate the need for communities globally to counter this targeted marketing by taking policy action specifically through the enactment of marketing restrictions provided by the 2009 Family Smoking Prevention and Tobacco Control Act and the Framework Convention of Tobacco Control.

Northeastern Regional Geologic Characterization Report: executive summary. Final report

International Nuclear Information System (INIS)

1985-08-01

This Executive Summary of the final Northeastern Regional Geologic Characterization Report (RGCR) is issued primarily for public information purposes and provides a general overview of the report. The complete RGCR presents available regional geologic information pertinent to siting a repository for high-level nuclear waste in crystalline rock in Connecticut, Maine, Massachusetts, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, and Vermont. For each of the states within the Northeastern Region, information is provided on the geologic disqualifying factor and the geologic regional screening variables to be used in region-to-area screening. 5 refs., 3 figs

FWP executive summaries: basic energy sciences materials sciences and engineering program (SNL/NM).

Energy Technology Data Exchange (ETDEWEB)

Samara, George A.; Simmons, Jerry A.

2006-07-01

This report presents an Executive Summary of the various elements of the Materials Sciences and Engineering Program which is funded by the Division of Materials Sciences and Engineering, Office of Basic Energy Sciences, U.S. Department of Energy at Sandia National Laboratories, New Mexico. A general programmatic overview is also presented.

Planning manual for energy resource development on Indian lands. Executive summary

Energy Technology Data Exchange (ETDEWEB)

1978-03-01

This report is the Executive Summary for the other 5 volumes of the Study Report--see TID-28526/1-5. Information is provided here that the tribes can use to make energy-development decisions. The report is particularly concerned with management responsibilities and financial commitments that development will require on the part of the tribes and with the types of information and skilled personnel the tribes will need in the future to make informed decisions.

NNAL exposure by race and menthol cigarette use among U.S. smokers.

Science.gov (United States)

Rostron, Brian

2013-05-01

Researchers have recently suggested that nicotine and carcinogen exposure as measured by biomarkers such as cotinine and NNAL (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol) does not vary with cigarettes smoked per day (CPD) among Black smokers. Researchers have also suggested that nicotine exposure does not differ between menthol and nonmenthol smokers. In this study, we examine NNAL exposure for U.S. smokers by race, CPD, and menthol cigarette use. We analyzed urinary NNAL concentrations for more than 1500 everyday smokers participating in the National Health and Nutrition Examination Survey from 2007-2010. For purposes of comparison, we also analyzed serum cotinine concentrations for these smokers. We used linear regression analysis to estimate mean biomarker concentrations by CPD and race/ethnicity group and to examine the association between biomarker concentrations and menthol cigarette use by race/ethnicity group, controlling for other demographic and smoking characteristics. Biomarker concentrations increased with CPD for White, Black, and Hispanic smokers although NNAL concentrations leveled off for Black smokers at lower CPD levels compared with other smokers. Mean NNAL concentrations were lower among menthol smokers compared with nonmenthol smokers among smokers overall (β = -0.165, p = .032) and White smokers (β = -0.207, p = .048). We find evidence in national health survey data that nicotine and carcinogen exposure generally increases with CPD across race/ethnicity groups although the pattern of NNAL exposure differs by race/ethnicity group at high CPD levels. We also find evidence of differences in NNAL exposure for menthol smokers compared with nonmenthol smokers among smokers overall and White smokers.

The Irreplaceables: Understanding the Real Retention Crisis in America's Urban Schools. Executive Summary

Science.gov (United States)

TNTP, 2012

2012-01-01

Discussions of teacher turnover usually focus on "how many" teachers leave schools each year, without regard for their performance in the classroom. This oversimplification masks the real teacher retention crisis: not only a failure to retain enough teachers, but a failure to retain the "right" teachers. This executive summary presents findings of…

Comparative glandular trichome transcriptome-based gene characterization reveals reasons for differential (-)-menthol biosynthesis in Mentha species.

Science.gov (United States)

Akhtar, Md Qussen; Qamar, Nida; Yadav, Pallavi; Kulkarni, Pallavi; Kumar, Ajay; Shasany, Ajit Kumar

2017-06-01

The genes involved in menthol biosynthesis are reported earlier in Mentha × piperita. But the information on these genes is not available in Mentha arvensis. To bridge the gap in knowledge on differential biosynthesis of monoterpenes leading to compositional variation in the essential oil of these species, a comparative transcriptome analysis of the glandular trichome (GT) was carried out. In addition to the mevalonic acid (MVA) and methylerythritol phosphate (MEP) pathway genes, about 210 and 196 different terpene synthases (TPSs) transcripts were identified from annotation in M. arvensis and M. × piperita, respectively, and correlated to several monoterpenes present in the essential oil. Six isoforms of (-)-menthol dehydrogenases (MD), the last enzyme of the menthol biosynthetic pathway, were identified, cloned and characterized from the transcriptome data (three from each species). Varied expression levels and differential enzyme kinetics of these isoforms indicated the nature and composition of the product, as these isoforms generate both (-)-menthol and (+)-neomenthol from (-)-menthone and converts (-)-menthol to (-)-menthone in the reverse reaction, and hence together determine the quantity of (-)-menthol in the essential oil in these two species. Several genes for high value minor monoterpenes could also be identified from the transcriptome data. © 2017 Scandinavian Plant Physiology Society.

Disparities and Menthol Marketing: Additional Evidence in Support of Point of Sale Policies

Science.gov (United States)

Moreland-Russell, Sarah; Harris, Jenine; Snider, Doneisha; Walsh, Heidi; Cyr, Julianne; Barnoya, Joaquin

2013-01-01

This study examined factors associated with point-of-sale tobacco marketing in St. Louis, an urban city in the United States. Using spatial analysis, descriptive statistics, and multilevel modeling, we examined point-of-sale data and the proportion of mentholated cigarette and total cigarette marketing from 342 individual tobacco retail stores within St. Louis census tracts characterized by the percent of black adults and children. Menthol and total tobacco product marketing was highest in areas with the highest percentages of black residents. When examining menthol marketing to children, we did not find as strong of a relationship, however results of multilevel modeling indicate that as the proportion of black children in a census tract increased, the proportion of menthol marketing near candy also increased. These results indicate the need for communities globally to counter this targeted marketing by taking policy action specifically through the enactment of marketing restrictions provided by the 2009 Family Smoking Prevention and Tobacco Control Act and the Framework Convention of Tobacco Control. PMID:24071922

Disparities and Menthol Marketing: Additional Evidence in Support of Point of Sale Policies

Directory of Open Access Journals (Sweden)

Joaquin Barnoya

2013-09-01

Full Text Available This study examined factors associated with point-of-sale tobacco marketing in St. Louis, an urban city in the United States. Using spatial analysis, descriptive statistics, and multilevel modeling, we examined point-of-sale data and the proportion of mentholated cigarette and total cigarette marketing from 342 individual tobacco retail stores within St. Louis census tracts characterized by the percent of black adults and children. Menthol and total tobacco product marketing was highest in areas with the highest percentages of black residents. When examining menthol marketing to children, we did not find as strong of a relationship, however results of multilevel modeling indicate that as the proportion of black children in a census tract increased, the proportion of menthol marketing near candy also increased. These results indicate the need for communities globally to counter this targeted marketing by taking policy action specifically through the enactment of marketing restrictions provided by the 2009 Family Smoking Prevention and Tobacco Control Act and the Framework Convention of Tobacco Control.

Annual report of the Association EURATOM-Cea 2004 (executive summary)

International Nuclear Information System (INIS)

2004-01-01

Progress in fusion technology is constant over the years and this report once again highlights a number of important steps that have been accomplished in this domain. This document is the executive summary of the full annual report, summarizing activities performed by the EURATOM-Cea association. This report has been organized into 10 issues: 1) physics integration, 2) reactor vessel, 3) plasma facing components, 4) remote handling, 5) magnets structures, 6) tritium breeding blankets, 7) structural material, 8) safety and environment, 9) system study, and 10) ITER site preparation

North Central Regional Geologic Characterization Report. Executive summary. Final report

International Nuclear Information System (INIS)

1985-08-01

This Executive Summary of the final North Central Regional Geologic Characterization Report (RGCR) is issued primarily for public information purposes and provides a general overview of the report. The complete RGCR presents available regional geologic information pertinent to siting a repository for high-level nuclear waste in crystalline rock in Minnesota, Wisconsin, and the Upper Peninsula of Michigan. For each of the states within the North Central Region, information is provided on the geologic disqualifying factor and the geologic regional screening variables to be used in region-to-area screening

Annual report of the Association EURATOM-Cea 2005 (executive summary)

International Nuclear Information System (INIS)

2005-01-01

Progress in fusion technology is constant over the years and this report once again highlights a number of important steps that have been accomplished in this domain. This document is the executive summary of the full annual report, summarizing activities performed by the EURATOM-Cea association. This report has been organized into 10 issues: 1) physics integration, 2) reactor vessel, 3) plasma facing components, 4) remote handling, 5) magnets structures, 6) tritium breeding blankets, 7) structural material, 8) safety and environment, 9) system study, and 10) ITER site preparation

Executive summary of the energy balance from Sao Paulo State, Brazil, 1996. Base year: 1995

International Nuclear Information System (INIS)

1996-01-01

This document presents a executive summary of the energy balance in the year 1995, reporting the energy consumption considering the energy market dynamics and increasing ratio in the residential, public, commercial, agricultural, cattle breeding, transportation and industry areas

Structure of the cold- and menthol-sensing ion channel TRPM8.

Science.gov (United States)

Yin, Ying; Wu, Mengyu; Zubcevic, Lejla; Borschel, William F; Lander, Gabriel C; Lee, Seok-Yong

2018-01-12

Transient receptor potential melastatin (TRPM) cation channels are polymodal sensors that are involved in a variety of physiological processes. Within the TRPM family, member 8 (TRPM8) is the primary cold and menthol sensor in humans. We determined the cryo-electron microscopy structure of the full-length TRPM8 from the collared flycatcher at an overall resolution of ~4.1 ångstroms. Our TRPM8 structure reveals a three-layered architecture. The amino-terminal domain with a fold distinct among known TRP structures, together with the carboxyl-terminal region, forms a large two-layered cytosolic ring that extensively interacts with the transmembrane channel layer. The structure suggests that the menthol-binding site is located within the voltage-sensor-like domain and thus provides a structural glimpse of the design principle of the molecular transducer for cold and menthol sensation. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Hanford Site Environment Safety and Health (ES and H) FY 1999 and FY 2000 Execution Commitment Summary

Energy Technology Data Exchange (ETDEWEB)

REEP, I.E.

1999-12-01

All sites in the U.S. Department of Energy (DOE) Complex prepare this report annually for the DOE Office of Environment, Safety and Health (EH). The purpose of this report is to provide a summary of the previous and current year's Environment, Safety and Health (ES&H) execution commitments and the S&H resources that support these activities. The fiscal year (FY) 1999 and 2000 information (Sieracki 1999) and data contained in the ''Hanford Site Environment, Safety and Health Fiscal Year 2001 Budget-Risk Management Summary'' (RL 1999) were the basis for preparing this report. Fiscal year 2000 finding of Office of Environmental Management (EM) and Office of Nuclear Energy, Science and Technology (NE) activities is based on the President's budget of $1,065.1 million and $28.0 million, plus $2.7 million carryover finding, respectively, as of October 31, 1999. Any funding changes as a result of the Congressional appropriation process will be reflected in the Fiscal Year 2002 ES&H Budget-Risk Management Summary to be issued in May 2000. This report provides the end-of-year status of FY 1999 ES&H execution commitments, including actual S&H expenditures, and describes planned FY 2000 ES&H execution commitments and the S&H resources needed to support those activities. This requirement is included in the ES&H ''Guidance for FY200l Budget Formulations and Execution'' (DOE 1999).

Menthol Enhances Nicotine Reward-Related Behavior by Potentiating Nicotine-Induced Changes in nAChR Function, nAChR Upregulation, and DA Neuron Excitability.

Science.gov (United States)

Henderson, Brandon J; Wall, Teagan R; Henley, Beverley M; Kim, Charlene H; McKinney, Sheri; Lester, Henry A

2017-11-01

Understanding why the quit rate among smokers of menthol cigarettes is lower than non-menthol smokers requires identifying the neurons that are altered by nicotine, menthol, and acetylcholine. Dopaminergic (DA) neurons in the ventral tegmental area (VTA) mediate the positive reinforcing effects of nicotine. Using mouse models, we show that menthol enhances nicotine-induced changes in nicotinic acetylcholine receptors (nAChRs) expressed on midbrain DA neurons. Menthol plus nicotine upregulates nAChR number and function on midbrain DA neurons more than nicotine alone. Menthol also enhances nicotine-induced changes in DA neuron excitability. In a conditioned place preference (CPP) assay, we observed that menthol plus nicotine produces greater reward-related behavior than nicotine alone. Our results connect changes in midbrain DA neurons to menthol-induced enhancements of nicotine reward-related behavior and may help explain how smokers of menthol cigarettes exhibit reduced cessation rates.

Determining non-cigarette tobacco, alcohol, and substance use typologies across menthol and non-menthol smokers using latent class analysis

Directory of Open Access Journals (Sweden)

Amy M. Cohn

2017-01-01

LCA allowed for the identification of distinct classes of smokers based on factors related to poor cessation outcomes, including menthol use, that have not previously been examined in combination. Interventions should target specific groups of smokers, rather than take a “one size fits all” approach.

Synergistic anticandidal activity of menthol in combination with itraconazole and nystatin against clinical Candida glabrata and Candida krusei isolates.

Science.gov (United States)

Sharifzadeh, Aghil; Khosravi, Ali Reza; Shokri, Hojjatollah; Tari, Paria Samadi

2017-06-01

Candida glabrata (C. glabrata) and C. krusei are now emerging as serious hospital acquired infections in immunocompromised patients. Menthol, a terpenic compound, has been reported to have antifungal activity. The aim of this study was to investigate the effect of menthol in combination with itraconazole or nystatin against C. glabrata and C. krusei isolates. The effects of menthol along with itraconazole and nystatin, were evaluated by the Clinical Laboratory Standards Institute (CLSI) M44-A and CLSI M27-A3 methods. The fractional inhibitory concentration index (FICI) was determined for menthol plus itraconazole and nystatin combinations using the checkerboard method. The mean of minimum inhibitory concentration (MIC) values of menthol, nystatin and itraconazole were 53.2, 2.30 and 1.50 μg/ml for C. glabrata isolates and 121, 1.08 and 0.38 μg/ml for C. krusei isolates, respectively. Menthol in combination with itraconazole or nystatin exhibited the synergistic effects against all species of Candida tested. FICI values for menthol plus itraconazole and nystatin combinations ranged from 0.250 to 0.561 and 0.139 to 0.623 for C. glabrata isolates, and 0.182 to 0.750 and 0.188 to 0.760 for C. krusei, respectively. These results support the potential use of menthol as an anticandidal agent, and it can be used complementarily with other conventional antifungal agents. Copyright © 2017. Published by Elsevier Ltd.

Harm Perceptions of Menthol and Nonmenthol Cigarettes Differ by Brand, Race/Ethnicity, and Gender in US Adult Smokers: Results from PATH Wave 1.

Science.gov (United States)

Cohn, Amy M; Rose, Shyanika W; Ilakkuvan, Vinu; Gray, Tiffany; Curry, Laurel; Villanti, Andrea C; Mays, Darren; Lindblom, Eric; Tercyak, Kenneth; Debnam, Charles; Mayo, Ashley; Perreras, Lexie

2018-01-27

Harm perceptions of menthol cigarettes may contribute to their appeal and use. African-Americans, women, and younger smokers disproportionately use menthol cigarettes, and may misperceive harm of menthol cigarettes. Data were from Wave 1 of the Population Assessment of Tobacco and Health (PATH) Study. Weighted analyses of current adult smokers (18 and older) were used to estimate the correlates of menthol smoking among all cigarette brands and separately for the top three cigarette brands (Newport, Camel, and Marlboro). Adjusted models examined the main effect of menthol smoking on harm perceptions of one's own brand of cigarette and interactions with race/ethnicity, age, and gender. Menthol cigarettes were used by nearly 40% of current smokers, although the prevalence of menthol smoking differed across the top three brands (94% Newport, 46% Camel, and 18% Marlboro). Among menthol smokers, 80% perceived their cigarette as equally harmful, 14% perceived their brand as more harmful, and 7% perceived their brand as less harmful. In adjusted models, menthol smokers were more likely than nonmenthol smokers to misperceive their own brand as more harmful than other brands (compared to no difference in harm). Race and gender emerged as moderators of the association between menthol brand preference and harm perceptions. In adjusted analyses, menthol smokers were more likely than nonmenthol smokers to perceive their brand as more harmful than other brands, with differences by sub-groups who disproportionately use menthol. Menthol cigarettes have been historically marketed with messages conveying lower harm than other cigarettes. Little is known about how contemporary adult menthol smokers perceive the harm of their usual brand, and potential differences by race, gender, and young adult versus older adult age group. After adjusting for other factors, menthol smokers were more likely than nonmenthol smokers to perceive their cigarette brand as more harmful than other brands

Targeted advertising, promotion, and price for menthol cigarettes in California high school neighborhoods.

Science.gov (United States)

Henriksen, Lisa; Schleicher, Nina C; Dauphinee, Amanda L; Fortmann, Stephen P

2012-01-01

To describe advertising, promotions, and pack prices for the leading brands of menthol and nonmenthol cigarettes near California high schools and to examine their associations with school and neighborhood demographics. In stores (n = 407) within walking distance (0.8 km [1/2 mile]) of California high schools (n = 91), trained observers counted ads for menthol and nonmenthol cigarettes and collected data about promotions and prices for Newport and Marlboro, the leading brand in each category. Multilevel modeling examined the proportion of all cigarette advertising for any menthol brand, the proportion of stores with sales promotions, and the lowest advertised pack price in relation to store types and school/neighborhood demographics. For each 10 percentage point increase in the proportion of Black students, the proportion of menthol advertising increased by 5.9 percentage points (e.g., from an average of 25.7%-31.6%), the odds of a Newport promotion were 50% higher (95% CI = 1.01, 2.22), and the cost of Newport was 12 cents lower (95% CI = -0.18, -0.06). By comparison, the odds of a promotion and the price for Marlboro, the leading brand of nonmenthol cigarettes, were unrelated to any school or neighborhood demographics. In high school neighborhoods, targeted advertising exposes Blacks to more promotions and lower prices for the leading brand of menthol cigarettes. This evidence contradicts the manufacturer's claims that the availability of its promotions is not based on race/ethnicity. It also highlights the need for tobacco control policies that would limit disparities in exposure to retail marketing for cigarettes.

CONVERSION OF (±-CITRONELLAL AND ITS DERIVATIVES TO (--MENTHOL USING BIFUNCTIONAL NICKEL ZEOLITE CATALYSTS

Directory of Open Access Journals (Sweden)

Indri Badria Adilina

2015-06-01

Full Text Available (±-Citronellal and its derivatives were converted to (--menthol by a one-pot reaction system using zeolite based nickel catalysts. The catalysts were prepared by immobilization of nickel on natural zeolite (NZ or synthetic zeolite (ZSM-5 by a simple cation exchange method. Calcination and hydrogen treatment procedures were able to significantly increase the surface area and pore volume of NZ based catalysts whereas negligible changes in the properties were observed for that of ZSM-5. Catalytic reactions were carried out at 70ºC by stirring the mixture in the air for cyclization of (±-citronellal to (±-isopulegol followed by hydrogenation towards the desired (--menthol at 2 Mpa of H2 pressure. The Ni/NZ catalyst was able to convert a (±-citronellal derivative yielding 9% (--menthol (36% selectivity with conversion up to 24%, whereas Ni/ZSM5 catalyst directly converted 65% (±-citronellal to give 4% menthol (6% selectivity. These zeolite based catalysts are therefore potential materials for the conversion of biomass feed stock to value-added chemicals.

IFMIF : International Fusion Materials Irradiation Facility Conceptual Design Activity: Executive summary

International Nuclear Information System (INIS)

1997-01-01

This report is a summary of the results of the Conceptual Design Activity (CDA) on the International Fusion Materials Irradiation Facility (IFMIF), conducted during 1995 and 1996. The activity is under the auspices of the International Energy Agency (IEA) Implementing Agreement for a Programme of Research and Development on Fusion Materials. An IEA Fusion Materials Executive Subcommittee was charged with overseeing the IFMIF-CDA work. Participants in the CDA are the European Union, Japan, and the United States, with the Russian Federation as an associate member

IFMIF : International Fusion Materials Irradiation Facility Conceptual Design Activity: Executive summary

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-01-01

This report is a summary of the results of the Conceptual Design Activity (CDA) on the International Fusion Materials Irradiation Facility (IFMIF), conducted during 1995 and 1996. The activity is under the auspices of the International Energy Agency (IEA) Implementing Agreement for a Programme of Research and Development on Fusion Materials. An IEA Fusion Materials Executive Subcommittee was charged with overseeing the IFMIF-CDA work. Participants in the CDA are the European Union, Japan, and the United States, with the Russian Federation as an associate member.

Building Management Information Systems to Coordinate Citywide Afterschool Programs: A Toolkit for Cities. Executive Summary

Science.gov (United States)

Kingsley, Chris

2012-01-01

This executive summary describes highlights from the report, "Building Management Information Systems to Coordinate Citywide Afterschool Programs: A Toolkit for Cities." City-led efforts to build coordinated systems of afterschool programming are an important strategy for improving the health, safety and academic preparedness of children…

Assessment of the abuse liability of three menthol Vuse Solo electronic cigarettes relative to combustible cigarettes and nicotine gum.

Science.gov (United States)

Stiles, Mitchell F; Campbell, Leanne R; Jin, Tao; Graff, Donald W; Fant, Reginald V; Henningfield, Jack E

2018-05-03

We previously reported that following a short-term product use period, use of non-menthol Vuse Solo electronic cigarettes (ECs) resulted in product effect-related subjective responses and nicotine uptake between those of combustible cigarettes (high-abuse liability comparator) and nicotine gum (low-abuse liability comparator); the results were generally closer to those of nicotine gum. Using a similar design to the previous study, we evaluated the abuse liability of three menthol-flavored Vuse Solo ECs with the same nicotine contents (14, 29, and 36 mg) in a group of EC-naïve, menthol cigarette smokers, relative to comparator products. Six-hour nicotine uptake and ratings of subjective effects were used to determine abuse liability and pharmacokinetics. Use of menthol Vuse Solo resulted in significantly lower responses to subjective measurements (product liking, intent to use product again, and liking of positive product effects), higher urge to smoke responses, and a lower peak (C max ) and overall extent (AUC 0-360 ) of nicotine uptake compared to smoking the usual brand menthol cigarette. When compared with use of nicotine gum, subjective responses to use of menthol Vuse ECs were in the same direction as those resulting from smoking cigarettes but were more similar to nicotine gum use in magnitude than they were to cigarettes. These findings are concordant with our previous results and provide evidence that menthol Vuse Solo ECs have abuse liability that is lower than menthol cigarettes and potentially greater than that of nicotine gum. ClinicalTrials.gov identifier: NCT02664012.

Targeted Advertising, Promotion, and Price For Menthol Cigarettes in California High School Neighborhoods

Science.gov (United States)

Schleicher, Nina C.; Dauphinee, Amanda L.; Fortmann, Stephen P.

2012-01-01

Objectives: To describe advertising, promotions, and pack prices for the leading brands of menthol and nonmenthol cigarettes near California high schools and to examine their associations with school and neighborhood demographics. Methods: In stores (n = 407) within walking distance (0.8 km [1/2 mile]) of California high schools (n = 91), trained observers counted ads for menthol and nonmenthol cigarettes and collected data about promotions and prices for Newport and Marlboro, the leading brand in each category. Multilevel modeling examined the proportion of all cigarette advertising for any menthol brand, the proportion of stores with sales promotions, and the lowest advertised pack price in relation to store types and school/neighborhood demographics. Results: For each 10 percentage point increase in the proportion of Black students, the proportion of menthol advertising increased by 5.9 percentage points (e.g., from an average of 25.7%–31.6%), the odds of a Newport promotion were 50% higher (95% CI = 1.01, 2.22), and the cost of Newport was 12 cents lower (95% CI = −0.18, −0.06). By comparison, the odds of a promotion and the price for Marlboro, the leading brand of nonmenthol cigarettes, were unrelated to any school or neighborhood demographics. Conclusions: In high school neighborhoods, targeted advertising exposes Blacks to more promotions and lower prices for the leading brand of menthol cigarettes. This evidence contradicts the manufacturer’s claims that the availability of its promotions is not based on race/ethnicity. It also highlights the need for tobacco control policies that would limit disparities in exposure to retail marketing for cigarettes. PMID:21705460

A solar regenerative thermoelectrochemical converter (RTEC). Executive summary of final subcontract report

Energy Technology Data Exchange (ETDEWEB)

Townsend, C.W.; McHardy, J. [Hughes Aircraft Co., El Segundo, CA (United States)

1992-02-01

This is an executive summary of a final subcontract report that describes the successful completion of a closed-loop demonstration of a regenerative thermoelectromechanical device using solar heat input for the production of electricity. The full report, which contains a detailed description of the two-year effort, is currently subject to a government secrecy order which precludes public release of the information. Copies of the full report will be made available for general release whenever the secrecy order is lifted.

Desensitization of menthol-activated cold receptors in lower extremities during local cooling in young women with a cold constitution.

Science.gov (United States)

Yamazaki, Fumio; Sone, Ryoko

2017-03-01

To test the hypothesis that topical menthol-induced reactivity of cold sensation and cutaneous vasoconstriction to local cooling is augmented in individuals with a cold constitution, we examined thermal sensation and cutaneous vasoconstrictor responses at menthol-treated and untreated sites in the legs during local skin cooling in young women complaining of chilliness (C group) and young women with no complaint as a normal control group (N group). During local skin cooling, the sensitivity to cold sensation was greater in the C group than in the N group. The application of menthol enhanced the cold sensation at a low temperature in the N group, but not in the C group. Cutaneous vasoconstrictor responses to local skin cooling were not altered by menthol treatment in either of the two groups. These findings suggest the desensitization of menthol-activated cold receptors in the legs of C group subjects, and a minor role of cold receptor activity in cutaneous vasoconstrictor response to local cooling.

Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease, GOLD Executive Summary

DEFF Research Database (Denmark)

Vestbo, Jørgen; Hurd, Suzanne S; Agusti, Alvar G

2013-01-01

Chronic obstructive pulmonary disease (COPD) is a global health problem and since 2001 the Global Initiative for Chronic Obstructive Lung Disease (GOLD) has published its strategy document for the diagnosis and management of COPD. This executive summary presents the main contents of the second 5...

Transuranic waste form characterization and data base. Executive summary

International Nuclear Information System (INIS)

1980-01-01

The Transuranic Waste Form Characterization and Data Base (Volume 1) provides a wide range of information from which a comprehensive data base can be established and from which standards and criteria can be developed for the present NRC waste management program. Supplementary information on each of the areas discussed in Volume 1 is presented in Appendices A through K (Volumes 2 and 3). The structure of the study (Volume 1) is outlined and appendices of Volumes 2 and 3 correlate with each main section of the report. The Executive Summary reviews the sources, quantities, characteristics and treatment of transuranic wastes in the United States. Due to the variety of potential treatment processes for transuranic wastes, the end products for long-term storage may have corresponding variations in quantities and characteristics

Belgian Workshop (November 2003) - Executive Summary and International Perspective

International Nuclear Information System (INIS)

2004-01-01

delegates to learn about the history, the natural environment and the socio-economic circumstances of potential host communities, as well as the day-by-day experiences of local people, involved in the local partnerships Visits also provided for interactions and exchange between local stakeholders and the FSC community. During Day 3 the central theme of the workshop was addressed. Invited plenary speakers including local stakeholders and social scientists gave presentations on how to integrate multiple interests, values and knowledge into joint risk management. Presentations provided a background to subsequent round table discussions, which allowed local stakeholders and international delegates to interact and exchange in detail. On Day 4 morning a panel discussion took place which focused on the design of a repository and investigated how it could reflect a plurality of interests, values, and knowledge. The rest of Day 4 was devoted to the feedback by two thematic rapporteurs. They evaluated the meeting from two distinct perspectives: that of urban and regional development, and of participatory decision making. This Executive Summary gives an overview of the presentations and discussions that took place at the workshop and the community visits. The structure of the Executive Summary follows the structure of the workshop itself. Complementary to this Executive Summary and also provided with this document, is a NEA Secretariat's reflection aiming to place the main lessons of the workshop into an international perspective

The Sensory Difference Threshold of Menthol Odor in Flavored Tobacco Determined by Combining Sensory and Chemical Analysis.

Science.gov (United States)

Krüsemann, Erna J Z; Cremers, Johannes W J M; Visser, Wouter F; Punter, Pieter H; Talhout, Reinskje

2017-03-01

Cigarettes are an often-used consumer product, and flavor is an important determinant of their product appeal. Cigarettes with strong nontobacco flavors are popular among young people, and may facilitate smoking initiation. Discriminating flavors in tobacco is important for regulation purposes, for instance to set upper limits to the levels of important flavor additives. We provide a simple and fast method to determine the human odor difference threshold for flavor additives in a tobacco matrix, using a combination of chemical and sensory analysis. For an example, the human difference threshold for menthol odor, one of the most frequently used tobacco flavors, was determined. A consumer panel consisting of 20 women compared different concentrations of menthol-flavored tobacco to unflavored cigarette tobacco using the 2-alternative forced choice method. Components contributing to menthol odor were quantified using headspace GC-MS. The sensory difference threshold of menthol odor corresponded to a mixture of 43 (37-50)% menthol-flavored tobacco, containing 1.8 (1.6-2.1) mg menthol, 2.7 (2.3-3.1) µg menthone, and 1.0 (0.9-1.2) µg neomenthyl acetate per gram of tobacco. Such a method is important in the context of the European Tobacco Product Directive, and the US Food and Drug Administration Tobacco Control Act, that both prohibit cigarettes and roll-your-own tobacco with a characterizing flavor other than tobacco. Our method can also be adapted for matrices other than tobacco, such as food. © The Author 2016. Published by Oxford University Press.

[Effects of menthol as an additive in tobacco products and the need for regulation].

Science.gov (United States)

Kahnert, S; Nair, U; Mons, U; Pötschke-Langer, M

2012-03-01

Menthol is the most widely used and the most prominent tobacco additive in tobacco products advertised and marketed by the tobacco industry. Besides its characteristic flavor, it possesses a variety of pharmacological properties facilitating tobacco smoke inhalation and potentiating dependence. These properties of menthol not only favor tobacco initiation and consumption but can also prevent smoking cessation. This article summarizes the effect of menthol as an additive in tobacco products and its effect on tobacco consumption that causes a number of chronic diseases and premature death and, therefore, counteracts tobacco control measures. Currently, there is no legislative regulation in Germany that considers the health hazard, addiction-enhancing and attractiveness-increasing properties of additives permitted in tobacco products. Effective regulation or even a ban could contribute to a reduction of tobacco consumption and, hence, save many people from a long-lasting tobacco dependence.

Acute effect of topical menthol on chronic pain in slaughterhouse workers with carpal tunnel syndrome: triple-blind, randomized placebo-controlled trial

DEFF Research Database (Denmark)

Sundstrup, Emil; Jakobsen, Markus Due; Brandt, Mikkel

2014-01-01

Topical menthol gels are classified "topical analgesics" and are claimed to relieve minor aches and pains of the musculoskeletal system. In this study we investigate the acute effect of topical menthol on carpal tunnel syndrome (CTS). We screened 645 slaughterhouse workers and recruited 10...... participants with CTS and chronic pain of the arm/hand who were randomly distributed into two groups to receive topical menthol (Biofreeze) or placebo (gel with a menthol scent) during the working day and 48 hours later the other treatment (crossover design). Participants rated arm/hand pain intensity during...... the last hour of work (scale 0-10) immediately before 1, 2, and 3 hours after application. Furthermore, global rating of change (GROC) in arm/hand pain was assessed 3 hours after application. Compared with placebo, pain intensity and GROC improved more following application of topical menthol (P = 0...

Acute Effect of Topical Menthol on Chronic Pain in Slaughterhouse Workers with Carpal Tunnel Syndrome: Triple-Blind, Randomized Placebo-Controlled Trial

Directory of Open Access Journals (Sweden)

Emil Sundstrup

2014-01-01

Full Text Available Topical menthol gels are classified “topical analgesics” and are claimed to relieve minor aches and pains of the musculoskeletal system. In this study we investigate the acute effect of topical menthol on carpal tunnel syndrome (CTS. We screened 645 slaughterhouse workers and recruited 10 participants with CTS and chronic pain of the arm/hand who were randomly distributed into two groups to receive topical menthol (Biofreeze or placebo (gel with a menthol scent during the working day and 48 hours later the other treatment (crossover design. Participants rated arm/hand pain intensity during the last hour of work (scale 0–10 immediately before 1, 2, and 3 hours after application. Furthermore, global rating of change (GROC in arm/hand pain was assessed 3 hours after application. Compared with placebo, pain intensity and GROC improved more following application of topical menthol (P=0.026 and P=0.044, resp.. Pain intensity of the arm/hand decreased by −1.2 (CI 95%: −1.7 to −0.6 following topical menthol compared with placebo, corresponding to a moderate effect size of 0.63. In conclusion, topical menthol acutely reduces pain intensity during the working day in slaughterhouse workers with CTS and should be considered as an effective nonsystemic alternative to regular analgesics in the workplace management of chronic and neuropathic pain.

Effects of menthol application on the skin during prolonged immersion in cool and cold water.

Science.gov (United States)

Botonis, P G; Kounalakis, S N; Cherouveim, E D; Koskolou, M D; Geladas, N D

2018-03-01

The aim of the study was to compare the effect of skin surface menthol application on rectal temperature (Tre) during prolonged immersion in cool and cold water. We hypothesized that menthol application would lead to a slower Tre decline due to the reduced heat loss as a consequence of the menthol-induced vasoconstriction and that this effect would be attenuated during cold-water immersion. Six male subjects were immersed for 55 minutes in stirred cool (24°C) or cold (14°C) water immediately after attaining a Tre of 38°C by cycling at 60% of maximum heart rate on two occasions: without (ΝM) and with (M) whole-body skin application of menthol cream. Tre, the proximal-distal skin temperature gradient, and oxygen uptake were continuously measured. ANOVA with repeated measures was employed to detect differences among variables. Significance level was set at 0.05. The area under the curve for Tre was calculated and was greater in 24°C M (-1.81 ± 8.22 a.u) compared to 24°C NM (-27.09 ± 19.09 a.u., P = .03, r = .90), 14°C NM (-18.08 ± 10.85 a.u., P = .03, r = .90), and 14°C M (-11.71 ± 12.58 a.u, P = .05, r = .81). In cool water, oxygen uptake and local vasoconstriction were increased (P ≤ .05) by 39 ± 25% and 56 ± 37%, respectively, with menthol compared to ΝM, while no differences were observed in cold water. Menthol application on the skin before prolonged immersion reduces heat loss resulting in a blunted Tre decline. However, such a response is less obvious at 14°C water immersion, possibly because high-threshold cold-sensitive fibers are already maximally recruited and the majority of cold receptors saturated. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Guidelines for the Prevention of Infections Associated With Combat-Related Injuries: 2011 Update (Executive Summary)

Science.gov (United States)

2011-08-01

employed at all deployed medical treatment facilities (MTF). These should include hand hygiene . with compli- ance monitoring. Infection control and...established infections where nosocomial pathogens, including multidrug~resistant. may be the in~ fecting agents (Table 3). 7. Selected agents should be dosed...REVIEW ARTICLE Executive Summary: Guidelines for the Prevention of Infections Associated With Combat-Related Injuries: 2011 Update Endorsed by the

Exploring the conformational landscape of menthol, menthone, and isomenthone: A microwave study

Directory of Open Access Journals (Sweden)

David eSchmitz

2015-03-01

Full Text Available The rotational spectra of the monoterpenoids menthol, menthone, and isomenthone are reportedin the frequency range of 2−8.5GHz, obtained with broadband Fourier-transform microwave spectroscopy.For menthol only one conformation was identified under the cold conditions of the molecularjet, whereas three conformations were observed for menthone and one for isomenthone. Theconformational space of the different molecules was extensively studied using quantum chemicalcalculations, and the results were compared with molecular parameters obtained by the measurements.Finally, a computer program is presented, which was developed to automatically identifydifferent species in a dense broadband microwave spectrum using calculated ab initio rotationalconstants as input.

Evaluation of Potential Effect of Menthol Solution on Oral Hygiene ...

African Journals Online (AJOL)

Tropical Journal of Pharmaceutical Research April 2015; 14 (4): 687-692 ... Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, ... Keywords: Menthol mouth rinse, Chlorhexidine, Dental plaque, Gingivitis, Oral hygiene ... International Pharmaceutical Abstract, Chemical Abstracts, Embase, Index ...

Executive Summary - Natural Gas and the Transformation of the U.S. Energy Sector: Electricity

Energy Technology Data Exchange (ETDEWEB)

Logan, J.; Heath, G.; Macknick, J.; Paranhos, E.; Boyd, W.; Carlson, K.

2013-01-01

In November 2012, the Joint Institute for Strategic Energy Analysis (JISEA) released a new report, 'Natural Gas and the Transformation of the U.S. Energy Sector: Electricity.' The study provides a new methodological approach to estimate natural gas related greenhouse gas (GHG) emissions, tracks trends in regulatory and voluntary industry practices, and explores various electricity futures. The Executive Summary provides key findings, insights, data, and figures from this major study.

Flat-plate solar array project. Volume 1: Executive summary

Science.gov (United States)

Callaghan, W.; Mcdonald, R.

1986-01-01

In 1975, the U.S. Government contracted the Jet Propulsion Lab. to develop, by 1985, in conjunction with industry, the photovoltaics (PV) module and array technology required for widespread use of photovoltaics as a significant terrestrial energy source. As a result, a project that eventually became known as the Flat Plate Solar Array (FSA) Project was formed to manage an industry, university, and Government team to perform the necessary research and development. The original goals were to achieve widespread commercial use of PV modules and arrays through the development of technology that would allow them to be profitably sold for $1.07/peak watts (1985 dollars). A 10% module conversion efficiency and a 20 year lifetime were also goals. It is intended that the executive summary provide the means by which one can gain a perspective on 11 years of terrestrial photovoltaic research and development conducted by the FSA Project.

Executive summary of safeguards systems concepts for nuclear material transportation. Final report

International Nuclear Information System (INIS)

Baldonado, O.C.; Kevany, M.; Rodney, D.; Pitts, D.; Mazur, M.

1977-09-01

The U.S. Nuclear Regulatory Commission contracted with System Development Corporation to develop integrated system concepts for the safeguard of special strategic nuclear materials (SSNM), which include plutonium, uranium 233 and uranium 235 of at least 20 percent enrichment, against malevolent action during interfacility transport. This executive summary outlines the conduct and findings of the project. The study was divided into three major subtasks: (1) The development of adversary action sequences; (2) The assessment of the vulnerability of the transport of nuclear materials to adversary action; (3) The development of conceptual safeguards system design requirements to reduce vulnerabilities

Research on choleretic effect of menthol, menthone, pluegone, isomenthone, and limonene in DanShu capsule.

Science.gov (United States)

Hu, Guanying; Yuan, Xing; Zhang, Sanyin; Wang, Ruru; Yang, Miao; Wu, Chunjie; Wu, Zhigang; Ke, Xiao

2015-02-01

Danshu capsule (DSC) is a medicinal compound in traditional Chinese medicine (TCM). It is commonly used for the treatment of acute & chronic cholecystitis as well as choleithiasis. To study its choleretic effect, healthy rats were randomly divided into DSC high (DSCH, 900mg/kg), medium (DSCM, 450mg/kg), and low (DSCL, 225mg/kg) group, Xiaoyan Lidan tablet (XYLDT, 750mg/kg), and saline group. The bile was collected for 1h after 20-minute stabilization as the base level, and at 1h, 2h, 3h, and 4h after drug administration, respectively. Bile volume, total cholesterol, and total bile acid were measured at each time point. The results revealed that DSC significantly stimulated bile secretion, decreased total cholesterol level and increased total bile acid level. Therefore, it had choleretic effects. To identify the active components contributing to its choleretic effects, five major constituents which are menthol (39.33mg/kg), menthone (18.02mg/kg), isomenthone (8.18mg/kg), pluegone (3.31mg/kg), and limonene (4.39mg/kg) were tested on our rat model. The results showed that menthol and limonene could promote bile secretion when compared to DSC treatment (p > 0.05); Menthol, menthol and limonene could significantly decrease total cholesterol level (plimonene. Crown Copyright © 2014. Published by Elsevier B.V. All rights reserved.

Richland Operations (DOE-RL) Environmental Safety Health (ES and H) FY 2000 and FY 2001 Execution Commitment Summary

Energy Technology Data Exchange (ETDEWEB)

REEP, I.E.

2000-12-01

All sites in the U.S. Department of Energy (DOE) Complex prepare this report annually for the DOE Office of Environment, Safety and Health (EH). The purpose of this report is to provide a summary of the previous and current year's Environment, Safety and Health (ES&H) execution commitments and the Safety and Health (S&H) resources that support these activities. The fiscal year (FY) 2000 and 2001 information and data contained in the Richland Operations Environment, Safefy and Health Fiscal Year 2002 Budget-Risk Management Summary (RL 2000a) were the basis for preparing this report. Fiscal year 2001 activities are based on the President's Amended Congressional Budget Request of $689.6 million for funding Ofice of Environmental Management (EM) $44.0 million for Fast Flux Test Facility standby less $7.0 million in anticipated DOE, Headquarters holdbacks for Office of Nuclear Energy, Science and Technology (NE); and $55.3 million for Safeguards and Security (SAS). Any funding changes as a result of the Congressional appropriation process will be reflected in the Fiscal Year 2003 ES&H Budget-Risk Management Summary to be issued in May 2001. This report provides the end-of-year status of FY 2000 ES&H execution commitments, including actual S&H expenditures, and describes planned FY 2001 ES&H execution commitments and the S&H resources needed to support those activities. This requirement is included in the ES&H guidance contained in the FY 2002 Field Budget Call (DOE 2000).

Menthol tobacco use is correlated with mental health symptoms in a national sample of young adults: implications for future health risks and policy recommendations

Directory of Open Access Journals (Sweden)

Amy M. Cohn

2016-01-01

Menthol is disproportionately used among young adults tobacco users with mental health problems, above and beyond the impact of a variety of other mental health and tobacco use risk factors. Findings suggest a strong link between menthol tobacco use and poor health outcomes. Policies should be developed to deter menthol tobacco use in vulnerable groups.

Strategies and Decision Support Systems for Integrating Variable Energy Resources in Control Centers for Reliable Grid Operations. Executive Summary

Energy Technology Data Exchange (ETDEWEB)

Jones, Lawrence E. [Alstom Grid, Inc., Washington, DC (United States)

2011-11-01

This is the executive summary for a report that provides findings from the field regarding the best ways in which to guide operational strategies, business processes and control room tools to support the integration of renewable energy into electrical grids.

African-American smokers and cancers of the lung and of the upper respiratory and digestive tracts. Is menthol part of the puzzle?

Science.gov (United States)

Richardson, T L

1997-03-01

The prevalence of cigarette smoking is higher among African Americans than among whites. African Americans have higher rates of lung cancer than whites, although they smoke fewer cigarettes. To explore this black-white difference in lung cancer rates, I examine various aspects of tobacco use in African-American smokers, including the age of initiation of smoking, quantity of cigarettes smoked, quit rates, level of nicotine dependence, biochemical differences, and brand preferences, specifically menthol brand cigarettes. I also review briefly the sequelae of patterns of tobacco use, including rates of lung and other tobacco-related cancers. A preference for mentholated cigarettes by African Americans is well documented and is one of the most striking differences between African-American and white smokers. Menthol brand preference has been investigated in an attempt to explain the black-white differences in rates of cancers of the lungs and the upper respiratory and digestive tracts. Also, studies have evaluated smoking behavior both with and without menthol and have explicitly examined the question of whether menthol use helps explain the black-white difference in lung cancer rates. The results of these studies are so far inconclusive with regard to the use of menthol and the risk of lung cancer developing. I provide practical suggestions for clinicians in counseling African-American smokers to quit smoking and to maintain a nonsmoking status.

Executive Summaries: CIL '90.

Science.gov (United States)

Elsweiler, John A., Jr.; And Others

1990-01-01

Presents summaries of 12 papers presented at the 1990 Computers in Libraries Conference. Topics discussed include online searching; microcomputer-based serials management; microcomputer-based workstations; online public access catalogs (OPACs); multitype library networking; CD-ROM searches; locally mounted online databases; collection evaluation;…

Determination of Dyclonine Hydrochloride by a HPLC Method and Camphor and Menthol by a GC Method in Compound Lotion

Directory of Open Access Journals (Sweden)

Suying Ma

2013-01-01

Full Text Available A high performance liquid chromatographic (HPLC method with UV detector for the determination of dyclonine hydrochloride and a gas chromatography (GC method with flame ionization detector (FID for the determination of camphor and menthol in lotion were developed. The developed HPLC method involved using a SinoChoom ODS-BP C18 reversed-phase column (5 μm, 4.6 mm × 200 mm and mobile phase consisting of acetonitrile : water : triethylamine in a ratio of 45 : 55 : 1.0; pH was adjusted to 3.5 with glacial acetic acid. The developed GC method for determination of camphor and menthol involved using an Agilent 19091J-413 capillary chromatographic column (30 m × 320 μm × 0.25 μm. The two methods were validated according to official compendia guidelines. The calibration of dyclonine hydrochloride for HPLC method was linear over the range of 20–200 μg/mL. The retention time was found at 6.0 min for dyclonine hydrochloride. The calibration of camphor and menthol of GC method was linear over the range of 10–2000 μg/mL. The retention time was found at 2.9 min for camphor and 3.05 min for menthol. The proposed HPLC and GC methods were proved to be suitable for the determination of dyclonine hydrochloride, camphor, and menthol in lotion.

Executive Headteachers: What's in a Name? Executive Summary

Science.gov (United States)

Theobald, Katy; Lord, Pippa

2016-01-01

Executive headteachers (EHTs) are becoming increasingly prevalent as the self-improving school system matures; there are over 620 EHTs in the school workforce today; and the number recorded in the School Workforce Census (SWC) has increased by 240 per cent between 2010 and 2014. The role is still evolving locally and nationally and, as EHTs take…

SHORT-TERM TOXICITY STUDY IN RATS DOSED WITH PULEGONE AND MENTHOL

DEFF Research Database (Denmark)

Thorup, I.; Würtzen, G.; Carstensen, J.

1983-01-01

creatinine content, lowered terminal body weight and caused histopathological changes in the liver and in the white matter of cerebellum. For menthol at all dose levels a significant increase in absolute and relative liver weights and vacuolisation of hepatocytes was found. No sign of encephalopathy...

Salinity does not alter the effectiveness of menthol as an anesthetic and sedative during the handling and transport of juvenile fat snook (Centropomus parallelus

Directory of Open Access Journals (Sweden)

L. C. O.’R. Sepulchro

Full Text Available Abstract The effectiveness of menthol as anesthetic and sedative for fat snook (Centropomus parallelus was tested at different salinities. In the first experiment, the fish were exposed to different concentrations of menthol (25, 37 and 50 mg L–1 in water at different salinities (0, 17 and 36 ppt. In the second experiment, the fish were transported for 10 hours in water with menthol at concentrations of 0, 3.7 and 7.4 mg L–1 under different salinities. Na+ and K+ ions from fish body and water were analyzed after transport. The optimal concentrations of menthol for a short handling period and surgical induction was 37 and 50 mg L–1, respectively, and these values were independent of salinity. After transport, neither mortality nor significant changes in ammonia or dissolved oxygen were observed between treatments at the different salinities. The nitrite levels were lower in freshwater than in brackish and saltwater, but did not change with mentol. The total body levels of Na+ increased with the salinity increase. Menthol is an effective anesthetic for handling of juvenile fat snook at different salinities. Menthol did not influence the measured water parameters and body ions, and it is not necessary for the transport of fat snook.

Salinity does not alter the effectiveness of menthol as an anesthetic and sedative during the handling and transport of juvenile fat snook (Centropomus parallelus).

Science.gov (United States)

Sepulchro, L C O 'r; Carvalho, M A G; Gomes, L C

2016-04-19

The effectiveness of menthol as anesthetic and sedative for fat snook (Centropomus parallelus) was tested at different salinities. In the first experiment, the fish were exposed to different concentrations of menthol (25, 37 and 50 mg L-1) in water at different salinities (0, 17 and 36 ppt). In the second experiment, the fish were transported for 10 hours in water with menthol at concentrations of 0, 3.7 and 7.4 mg L-1 under different salinities. Na+ and K+ ions from fish body and water were analyzed after transport. The optimal concentrations of menthol for a short handling period and surgical induction was 37 and 50 mg L-1, respectively, and these values were independent of salinity. After transport, neither mortality nor significant changes in ammonia or dissolved oxygen were observed between treatments at the different salinities. The nitrite levels were lower in freshwater than in brackish and saltwater, but did not change with mentol. The total body levels of Na+ increased with the salinity increase. Menthol is an effective anesthetic for handling of juvenile fat snook at different salinities. Menthol did not influence the measured water parameters and body ions, and it is not necessary for the transport of fat snook.

Effect of menthol coated craft paper on corrosion of copper in HCl ...

Indian Academy of Sciences (India)

Administrator

The effect of menthol on copper corrosion was studied by gravimetric and ... lable for temporary protection of metals and alloys from corrosion, the use of volatile .... The corrosion kinetic parameters were obtained from the anodic and cathodic.

Energy Audit for Moncrief Army Community Hospital, Oliver Dental Clinic, Caldwell Dental Clinic, and Hagen Dental Clinic, Volume 1 - Executive Summary

National Research Council Canada - National Science Library

1987-01-01

This is the Executive Summary of an Energy Engineering Analysis Program (EEAP) Study that was conducted at Moncrief Army Community Hospital, Fort Jackson, South Carolina, by the firm of BENATECH, INC. The Scope of Work...

Executive Summary: Enhanced Recovery After Surgery: Best Practice Guideline for Care of Patients With a Fecal Diversion.

Science.gov (United States)

Miller, Debbie; Pearsall, Emily; Johnston, Debra; Frecea, Monica; McKenzie, Marg

Enhanced Recovery After Surgery (ERAS) is a multimodal program developed to decrease postoperative complications, improve patient safety and satisfaction, and promote early discharge. In the province of Ontario, Canada, a standardized approach to the care of adult patients undergoing elective colorectal surgery (including benign and malignant diseases) was adopted by 15 hospitals in March 2013. All colorectal surgery patients with or without an ostomy were included in the ERAS program targeting a length of stay of 3 days for colon surgery and 4 days for rectal surgery. To ensure the individual needs of patients requiring an ostomy in an ERAS program were being met, a Provincial ERAS Enterostomal Therapy Nurse Network was established. Our goal was to develop and implement an evidence-based, ostomy-specific best practice guideline addressing the preoperative, postoperative, and discharge phases of care. The guideline was developed over a 3-year period. It is based on existing literature, guidelines, and expert opinion. This article serves as an executive summary for this clinical resource; the full guideline is available as Supplemental Digital Content 1 (available at: http://links.lww.com/JWOCN/A36) to this executive summary.

Executive Summary

International Nuclear Information System (INIS)

2014-01-01

Each session of the workshop consisted of a number of presentations followed by a panel discussion moderated by the session Chairs. A summary of each session and subsequent discussion that ensued are provided. Session 1: National approaches for long term interim storage facilities. Seven papers were presented during this session by representatives of research institutes in USA (EPRI) and in Norway (IFE), governmental authorities for the nuclear industry in Finland (STUK) and Slovak Republic (UJD), technical support organizations in Germany (GRS) and France (IRSN) and the public company in charge of waste management in Spain (ENRESA). The papers discussed the national policy, the regulatory framework and the current situation for storage of SF and HLW in various European countries (Germany, Spain, Finland, Norway and Slovak Republic). The main activities the EPRI is undertaking to establish the technical bases for extended (long-term) storage and the IRSN's definition of the safety principles and objectives for new storage facilities regarding long-term storage are also discussed. Session 2: Safety requirements, regulatory framework and implementation issues. Eleven papers were presented during this session by representatives from international groups (the International Atomic Energy Agency (IAEA) and the Nuclear Energy Agency (NEA)), representatives of regulatory bodies from the United States (Nuclear Regulatory Commission) and Germany (Bundesamt fuer Strahlenschutz (BfS)), German Federal Institute for Materials Research and Testing (BAM), operators from the United Kingdom (Sellafield Limited, UK) and France (EDF), vendors (AREVA), and representatives of TSOs in Germany (TUV and Oko-Institut). Session 3: Technical issues and operational experience, needs for R and D. This session was chaired by Karl Wasinger (AREVA, Germany) and Fumihisa Nagase (JAEA, Japan). Ten papers were presented during this session by representatives of research institutes of Japan (CRIEPI

Executive summary of the Cryofracture demonstration program

International Nuclear Information System (INIS)

Loomis, G.; Osborne, D.; Ancho, M.

1991-09-01

This report provides an executive summary of the Cryofracture demonstration program performed at Nuclear Remedial Technologies Corporation under contract to EG ampersand G Idaho, Inc., for the Department of Energy (DOE). Cryofracture is a size-reducing process whereby objects are frozen whereby objects are frozen to liquid nitrogen temperatures and crushed in a large hydraulic press. Material at the cryogenic temperatures have low ductility and are easily size reduced by fracturing. The main application being investigated for the DOE is for retrieved buried and stored transuranic (TRU) waste. Six 55-gallon drums and six 2 ft x 2 ft x 8 ft boxes containing simulated waste with tracers were subjected to the Cryofracture process. Data was obtained on (a) cool-down time, (b) yield strength of the containers, (c) size distribution of the waste before and after the Cryofracture process, (d) volume reduction of the waste, and (e) sampling of air and surface dusts for spread of tracers to evaluate potential contamination spread. The Cryofracture process was compared to conventional shredders and detailed cost estimates were established for construction of a Cryofracture facility at the Idaho National Engineering Laboratory. Although cost estimates for conventional shredding are higher for Cryofracture, the potential for fire and explosion during conventional shredding would incur additional costs to preclude these events. These additional costs are unknown and would require considerable research and development. 4 refs., 6 figs., 7 tabs

Effects of antagonists and heat on TRPM8 channel currents in dorsal root ganglion neuron activated by nociceptive cold stress and menthol.

Science.gov (United States)

Naziroğlu, Mustafa; Ozgül, Cemil

2012-02-01

Transient receptor potential ion channel melastatin subtype 8 (TRPM8) is activated by cold temperature and cooling agents, such as menthol and icilin. Compounds containing peppermint are reported to reduce symptoms of environmental cold stress such as cold allodynia in dorsal root ganglion (DRG) neuron; however, the underlying mechanisms of action are unclear. We tested the effects of physiological heat (37°C), anthralic acid (ACA and 0.025 mM), 2-aminoethyl diphenylborinate (2-APB and 0.05) on noxious cold (10°C) and menthol (0.1 mM)-induced TRPM8 cation channel currents in the DRG neurons of rats. DRG neurons were freshly isolated from rats. In whole-cell patch clamp experiments, TRPM8 currents were consistently induced by noxious cold or menthol. TRPM8 channels current densities of the neurons were higher in cold and menthol groups than in control. When the physiological heat is introduced by chamber TRPM8 channel currents were inhibited by the heat. Noxious cold-induced Ca(2+) gates were blocked by the ACA although menthol-induced TRPM8 currents were not blocked by ACA and 2-APB. In conclusion, the results suggested that activation of TRPM8 either by menthol or nociceptive cold can activate TRPM8 channels although we observed the protective role of heat, ACA and 2-APB through a TRPM8 channel in nociceptive cold-activated DRG neurons. Since cold allodynia is a common feature of neuropathic pain and diseases of sensory neuron, our findings are relevant to the etiology of neuropathology in DRG neurons.

Design, Scale up and Safe Piloting of Thymol Hydrogenation and Menthol Racemisation

Czech Academy of Sciences Publication Activity Database

Dudas, J.; Hanika, Jiří

2009-01-01

Roč. 87, č. 1 (2009), s. 83-90 ISSN 0263-8762 Institutional research plan: CEZ:AV0Z40720504 Keywords : thymol hydrogenation * menthol racemisation * trickle-bed reactor Subject RIV: CI - Industrial Chemistry, Chemical Engineering Impact factor: 1.223, year: 2009

On the development of a theory of traveler attitude-behavior interrelationships. Volume 3 : executive summary : overview of methods, results, and conclusions

Science.gov (United States)

1978-08-01

The executive summary of this Final Report offers an overview of : methods, results, and conclusions which support the development of a : theory of traveler attitude-behavior interrelationships. Such a theory : will be useful in the design of transpo...

Executive Summary: 30th Report on Physician Assistant Educational Programs in the United States.

Science.gov (United States)

Huang, Lindsey M

2015-09-01

The purpose of this executive summary was to provide an overview of key findings from By the Numbers: 30th Report on Physician Assistant Educational Programs in the United States. The 2014 Program Survey is a Web-based survey and is administered annually to all member physician assistant (PA) program directors. This executive summary will focus on 4 of the 7 sections of the survey instrument: general, financial, program personnel, and students. The typical PA program's sponsoring institution is private and in a nonacademic health center. Most PA programs (93.0%) offer a master's degree as the primary or highest credential. The average total program budget was $2,221,751 (SD=$2,426,852). The average total resident tuition was $64,961, and the average total nonresident tuition was $75,964. Overall, 181 programs reported 1843 program faculty. Of those, 1467 were identified as core faculty and 376 were identified as adjunct faculty. A typical first-year PA student is 26 years old (SD=2.51), female (70.3%, n=5898), non-Hispanic (89.3%, n=3631), White (79.9%, n=3712), and has an overall undergraduate and science grade point average (GPA) of 3.52 (SD=0.14) and 3.47 (SD=0.16), respectively. In 2014, there were approximately 7556 graduates from 164 responding programs. By gaining a better understanding of the characteristics of PA programs and their faculty and students, policy makers can be better informed. Physician assistant educators and stakeholders are encouraged to use this information to advance and advocate for the profession.

Menthol-induced bleaching rapidly and effectively provides experimental aposymbiotic sea anemones (Aiptasia sp.) for symbiosis investigations.

Science.gov (United States)

Matthews, Jennifer L; Sproles, Ashley E; Oakley, Clinton A; Grossman, Arthur R; Weis, Virginia M; Davy, Simon K

2016-02-01

Experimental manipulation of the symbiosis between cnidarians and photosynthetic dinoflagellates (Symbiodinium spp.) is crucial to advancing the understanding of the cellular mechanisms involved in host-symbiont interactions, and overall coral reef ecology. The anemone Aiptasia sp. is a model for cnidarian-dinoflagellate symbiosis, and notably it can be rendered aposymbiotic (i.e. dinoflagellate-free) and re-infected with a range of Symbiodinium types. Various methods exist for generating aposymbiotic hosts; however, they can be hugely time consuming and not wholly effective. Here, we optimise a method using menthol for production of aposymbiotic Aiptasia. The menthol treatment produced aposymbiotic hosts within just 4 weeks (97-100% symbiont loss), and the condition was maintained long after treatment when anemones were held under a standard light:dark cycle. The ability of Aiptasia to form a stable symbiosis appeared to be unaffected by menthol exposure, as demonstrated by successful re-establishment of the symbiosis when anemones were experimentally re-infected. Furthermore, there was no significant impact on photosynthetic or respiratory performance of re-infected anemones. © 2016. Published by The Company of Biologists Ltd.

Back from the Brink: How a Bold Vision and a Focus on Resources Can Drive System Improvement. Executive Summary

Science.gov (United States)

Education Resource Strategies, 2015

2015-01-01

This executive summary describes a case study that implemented the framework School System 20/20 to examine how Lawrence Public Schools (Massachusetts) is transforming its policies and structures to better align resources with student and teacher needs. Education Resource Strategies' (ERS') School System 20/20 is a set of conditions and practices…

CanVasc recommendations for the management of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides - Executive summary.

Science.gov (United States)

McGeoch, Lucy; Twilt, Marinka; Famorca, Leilani; Bakowsky, Volodko; Barra, Lillian; Benseler, Susan; Cabral, David A; Carette, Simon; Cox, Gerald P; Dhindsa, Navjot; Dipchand, Christine; Fifi-Mah, Aurore; Goulet, Michele; Khalidi, Nader; Khraishi, Majed M; Liang, Patrick; Milman, Nataliya; Pineau, Christian A; Reich, Heather; Samadi, Nooshin; Shojania, Kam; Taylor-Gjevre, Regina; Towheed, Tanveer E; Trudeau, Judith; Walsh, Michael; Yacyshyn, Elaine; Pagnoux, Christian

2015-01-01

The Canadian Vasculitis research network (CanVasc) is composed of physicians from different medical specialties, including rheumatology and nephrology and researchers with expertise in vasculitis. One of its aims was to develop recommendations for the diagnosis and management of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides in Canada. This executive summary features the 19 recommendations and 17 statements addressing general AAV diagnosis and management, developed by CanVasc group based on a synthesis of existing international guidelines, other published supporting evidence and expert consensus considering the Canadian healthcare context.

Guideline for the management of wounds in patients with lower-extremity venous disease: an executive summary.

Science.gov (United States)

Kelechi, Teresa J; Johnson, Jan J

2012-01-01

This article provides an executive summary of the lower extremity venous disease (LEVD) evidence-based guideline produced by the WOCN Wound Guidelines Task Force. The target audience for this guideline is health care professionals who specialize in, direct, or provide wound care for patients at risk for or with lower-extremity venous disease. The full guideline opens with an overview of definitions of LEVD, its prevalence, clinical relevance, etiology, related physiology and pathophysiology, and overall management goals for patients at risk for developing venous leg ulcers. A detailed assessment section describes how to conduct a full clinical history and physical examination. Two approaches to interventions are provided: one addresses prevention strategies to reduce the risk of developing LEVD with ulcers. Methods to prevent ulcer recurrence are summarized including compression therapy, adjunctive therapies, medications, and patient education. A second approach presents treatment interventions including wound cleansing, debridement, infection control, antibiotic use, along with management of the periwound skin, nutrition, pain, and edema. This section also discusses limb elevation, surgical options, adjunctive therapies, patient education, and health care provider follow-up. A comprehensive reference list, glossary of terms, and appendices on cellulitis and venous eczema, types of edema, and compression therapy are available at the end of the guideline. This article provides an executive summary of the essential features of the guideline.

Menthol cigarettes and smoking initiation: a tobacco industry perspective

OpenAIRE

Klausner, Kim

2011-01-01

Objectives To determine what the tobacco industry knew about menthol cigarettes and the initiation of smoking. Methods Based on Food and Drug Administration staff-supplied research questions we used a snowball sampling strategy to search the Legacy Tobacco Documents Library (http://legacy.library.ucsf.edu) between February and April 2010. Of the approximately 11 million documents available in the LTDL, the iterative searches returned tens of thousands of results. Researchers reviewed 2634 doc...

Effect of menthol and eugenol on the physiological responses of pacu Piaractus mesopotamicus

Directory of Open Access Journals (Sweden)

Milena Souza dos Santos Sanchez

2014-09-01

Full Text Available The present study the aim was evaluate induction time, recovery time and physiological responses of pacus Piaractus mesopotamicus submitted to eugenol and menthol usual doses. Were used 56 pacus, which were exposed to menthol 150 mgL-1 (n=24 and eugenol 100 mgL-1 (n=24 and the control group (n=24 which doesn’t were exposed to anesthetics. In the moment 0, 12 and 24 hours after induction were performed collection of blood in fish (n=8 for the hematologic parameters and plasma glucose evaluation. The recovery was conduced in aquariums free anesthetic, being induction and recovery times monitored. The results were submitted at analysis of variance (P<0.05 and the means when significant were compared by Tukey test (P<0.05. Both anesthetics in their respective concentrations induced fish to surgical anesthesia. There was no treatment effects on hematologic parameters, except for hemoglobin for which was observed interaction effect between factors, is significantly lower 150 mgL-1 showed significant reduction (P<0.05 of hemoglobin values 12 hours after induction, however these values remained unchanged 24 hours after anesthesia. Interaction effect (P<0.01 was observed between treatments and sampling times for the plasma glucose levels, because there was significant reduction in this levels 12 hours after anesthesia, and remained 24 hous after induction. Menthol 150 mgL-1 and eugenol 100 mgL-1 can be used safely in the pacus induction during realization of biometrics.

Executive summary of the consensus document on osteoporosis in HIV-infected individuals.

Science.gov (United States)

Negredo, Eugenia; Domingo, Pere; Gutiérrez, Félix; Galindo, María José; Knobel, Hernando; Lozano, Fernando; Martínez, Esteban; Masiá, Mar; Polo, Rosa; Estrada, Vicente

2018-05-01

Osteoporosis has become an emerging comorbid condition in people living with HIV (PLWH). The increase in survival and the progressive aging of PLWH will make this complication more frequent in the near future. In addition to the traditional risk factors affecting the general population, factors directly or indirectly associated with HIV infection, including antiretroviral therapy, can increase the risk of osteoporosis. The present article is an executive summary of the document that updates the previous recommendations on the prevention and treatment of osteoporosis in PLWH. This document is intended for all professionals who work in clinical practice in the field of HIV infection. Copyright © 2017 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

Comparison of serum cotinine concentration within and across smokers of menthol and nonmenthol cigarette brands among non-Hispanic black and non-Hispanic white U.S. adult smokers, 2001-2006.

Science.gov (United States)

Caraballo, Ralph S; Holiday, David B; Stellman, Steven D; Mowery, Paul D; Giovino, Gary A; Muscat, Joshua E; Eriksen, Michael P; Bernert, John T; Richter, Patricia A; Kozlowski, Lynn T

2011-07-01

The Food and Drug Administration (FDA) is examining options for regulating menthol content in cigarettes. There are many pharmacologic properties of menthol that may facilitate exposure to tobacco smoke, and it has been suggested that the preference for menthol cigarettes in black smokers accounts for their higher cotinine levels. To assess cigarettes smoked per day-adjusted cotinine levels in relation to smoking a menthol or nonmenthol cigarette brand among non-Hispanic black and white U.S. adult smokers under natural smoking conditions. Serum cotinine concentrations were measured in 1,943 smokers participating in the 2001 to 2006 National Health and Nutrition Examination Surveys (NHANES). The effect of smoking a menthol brand on cigarettes smoked per day-adjusted serum cotinine levels in these two populations was modeled by adjusting for sex, age, number of smokers living in the home, body weight, time since last smoked, and FTC (Federal Trade Commission)-measured nicotine levels. The 8- or 12-digit Universal Product Code (UPC) on the cigarette label was used to determine the cigarette brand and whether it was menthol. Smoking a menthol cigarette brand versus smoking a nonmenthol cigarette brand was not associated (P ≥ 0.05) with mean serum cotinine concentration in either black or white smokers. The higher levels of cotinine observed in black smokers compared with white smokers are not explained by their higher preference for menthol cigarette brands. Further studies like ours are needed to improve our ability to understand health consequences of future changes in tobacco product design. ©2011 AACR

Association between menthol cigarette smoking and current use of electronic cigarettes among us adolescents.

Directory of Open Access Journals (Sweden)

Israel Agaku

2017-05-01

Current e-cigarette use was significantly higher among menthol than nonmenthol cigarette smokers. These findings underscore the importance of efforts to reduce all forms of tobacco product use, including e-cigarettes, among youth.

The Oral Health Care Delivery System in 2040: Executive Summary.

Science.gov (United States)

Bailit, Howard L

2017-09-01

This executive summary for Section 4 of the "Advancing Dental Education in the 21 st Century" project examines the projected oral health care delivery system in 2040 and the likely impact of system changes on dental education. Dental care is at an early stage of major changes with the decline in solo practice and increase in large group practices. These groups are not consolidated at the state level, but further consolidation is expected as they try to increase their negotiating leverage with dental insurers. At this time, there is limited integration of medical and dental care in terms of financing, regulation, education, and delivery. This pattern may change as health maintenance organizations and integrated medical systems begin to offer dental care to their members. By 2040, it is expected that many dentists will be employed in large group practices and working with allied dental staff with expanded duties and other health professionals, and more dental graduates will seek formal postdoctoral training to obtain better positions in group practices.

Effects of caffeine and menthol on cognition and mood during simulated firefighting in the heat.

Science.gov (United States)

Zhang, Yang; Balilionis, Gytis; Casaru, Catalina; Geary, Colleen; Schumacker, Randall E; Neggers, Yasmin H; Curtner-Smith, Matthew D; Richardson, Mark T; Bishop, Phillip A; Green, James M

2014-05-01

This study examined the separate effects of caffeine and menthol on cognition and mood during simulated firefighting in the heat. Participants (N = 10) performed three trials in a counterbalanced order, either with 400 mg caffeine, menthol lozenges, or placebo. The simulated firefighting consisted of 2 bouts of 20-min treadmill exercise and one bout of 20-min stepping exercise in the heat with two brief 15-min rest periods between each exercise phase. Exercise induced significant dehydration (>3%) and elevated rectal temperature (>38.9 °C), for all three conditions. Neither caffeine nor menthol reduced perceived exertion compared to placebo (p > 0.05). Mood ratings (i.e., alertness, hedonic tone, tension) significantly deteriorated over time (p memory, and retrieval memory did not alter with treatments or repeated evaluations. Reaction accuracy from a math test remained unchanged throughout the experimental period; reaction time from the math test was significantly faster after exposure to the heat (p < 0.05). It is concluded that, exhaustive exercise in the heat severely impacted mood, but minimally impacted cognition. These treatments failed to show ergogenic benefits in a simulated firefighting paradigm in a hot environment. Copyright © 2013 Elsevier Ltd and The Ergonomics Society. All rights reserved.

2007-2008 activity report of the Association EURATOM-CEA (Executive summary)

International Nuclear Information System (INIS)

Labasse, F.

2008-01-01

This document is the executive summary of the full report, summarizing activities performed by EURATOM-CEA association in 2007-2008. The activities are various and have involved different issues like the study of dust generation processes and measurement techniques, ICRH antenna design for heating, integration studies inside the port-plug for diagnostics and in-situ divertor thermography, or the helium cooled lithium lead (HCLL) breeding blanket concept. Activities have been made to study the properties of the line defects governing the plastic behavior of iron base materials. Different options have been investigated for the superconducting magnet system. The measurement of in-vessel tritium inventory by laser induced breakdown spectroscopy (LIBS) technique has been investigated. 2007-2008 were also dedicated to the manufacture and complete tests of the AIA (Articulated Inspection Arm). AIA is designed to inspect divertor cassettes and the vacuum vessel first wall. Activities based on safety analysis or tests of ITER safety open issues have been carried out using several CEA facilities and expertise

New Education Advocacy Organizations in the U.S. States: National Snapshot and a Case Study of Advance Illinois. Executive Summary

Science.gov (United States)

Manna, Paul; Moffitt, Susan

2014-01-01

This executive summary describes a Wallace-commissioned report that identifies the emergence of a new kind of education advocacy organization in the United States. The report also assesses how these groups influence education policy, provides an overview of their work across the country, and offers a case study of one, Advance Illinois. The report…

Reducing barriers to energy efficiency in the German brewing sector. Executive Summary

Energy Technology Data Exchange (ETDEWEB)

Schleich, J.; Boede, U.; Ostertag, K.; Radgen, P.

2000-12-01

This report describes the empirical research into barriers to energy efficiency in the German brewing sector. It is one of nine such reports in the BARRIERS project. The report contains description and analysis of five case studies of energy management in German breweries. The results are analysed using the theoretical framework developed for the BARRIERS project. The report also provides brief recommendations on how these barriers to the rational use of energy (RUE) may be overcome and how energy efficiency within the brewing sector may be improved. The results of the study for the brewing sector in Germany are summarised in this executive summary under the following headings: - Characterising the brewing sector; - Case studies of energy management in the German brewing sector; - Evidence of barriers in the German brewing sector; - The role of energy service companies in the brewing sector; - Policy implications. (orig.)

Inventory of Federal energy-related environment and safety research for FY 1978. Volume 1. Executive summary

International Nuclear Information System (INIS)

1979-12-01

The FY 1978 Federal Inventory is a compilation of 3225 federally funded energy-related environmental and safety reserch projects. It consists of three volumes: an executive summary providing an overview of the data (Volume I), a catalog listing each Inventory project followed by series of indexes (Volume II), and an interactive terminal guide giving instructions for on-line data retrieval (Volume III). Volume I reviews the inventory data as a whole and also within each of three major categories: biomedical and environmental research, environmental control technology research, and operational safety research

CanVasc Recommendations for the Management of Antineutrophil Cytoplasm Antibody (ANCA-Associated Vasculitides – Executive Summary

Directory of Open Access Journals (Sweden)

Lucy McGeoch

2015-11-01

Full Text Available The Canadian Vasculitis research network (CanVasc is composed of physicians from different medical specialties, including rheumatology and nephrology and researchers with expertise in vasculitis. One of its aims was to develop recommendations for the diagnosis and management of antineutrophil cytoplasm antibody (ANCA-associated vasculitides in Canada. This executive summary features the 19 recommendations and 17 statements addressing general AAV diagnosis and management, developed by CanVasc group based on a synthesis of existing international guidelines, other published supporting evidence and expert consensus considering the Canadian healthcare context.

Waste Isolation Pilot Plant (WIPP) conceptual design report. Part I: executive summary. Part II: facilities and system

International Nuclear Information System (INIS)

1977-06-01

The pilot plant is developed for ERDA low-level contact-handled transuranic waste, ERDA remote-handled intermediate-level transuranic waste, and for high-level waste experiments. All wastes placed in the WIPP arrive at the site processed and packaged; no waste processing is done at the WIPP. All wastes placed into the WIPP are retrievable. The proposed site for WIPP lies 26 miles east of Carlsbad, New Mexico. This document includes the executive summary and a detailed description of the facilities and systems

Global Outlook on Sustainable Consumption and Production (SCP) Policies: Taking Action Together. Executive Summary

Energy Technology Data Exchange (ETDEWEB)

Beaton, Chris; Perera, Oshani [International Institute for Sustainable Development (IISD), Winnepeg, Ontario (Canada); Arden-Clarke, Charles; Farah, Adriana Zacarias; Polsterer, Nicole [UNEP, Paris (France)

2012-03-21

This executive summary, which will be complemented by the full report, was developed by the United Nations Environment Programme (UNEP) with the financial support of the European Commission, The study provides a non-exhaustive review of policies and initiatives that are promoting the shift towards Sustainable Consumption and Production (SCP) patterns. It is illustrated by 56 case studies ranging from global multilateral agreements and regional strategies to specific policies and initiatives being implemented by governments, businesses and civil society organizations. The main objectives are to provide information about existing activities promoting SCP, to identify best practices, and to provide recommendations to adapt, replicate and scale up SCP policies and initiatives contributing to the overarching goal of achieving sustainable development.

Building Student Momentum from High School into College. Ready or Not: It's Time to Rethink the 12th Grade. Executive Summary

Science.gov (United States)

Barnett, Elisabeth

2016-01-01

This executive summary describes a paper that is part of a series intended to encourage the nation's secondary and postsecondary systems to take joint responsibility for substantially increasing the number of young people who are prepared for college and career success. In this report, author Elisabeth Barnett of the Community College Research…

Association between menthol-flavoured cigarette smoking and flavoured little cigar and cigarillo use among African-American, Hispanic, and white young and middle-aged adult smokers.

Science.gov (United States)

Sterling, K; Fryer, C; Pagano, I; Jones, D; Fagan, P

2016-11-01

Flavour additives in cigarettes and little cigars and cigarillos (LCCs), which influence smokers' risk perceptions, may reinforce dual flavoured tobacco use. We examined the association among mentholated cigarette use, risk perceptions for flavour additives in LCCs and flavoured LCC smoking behaviour. Data from a national probability sample of 964 young and middle-aged adult current cigarette smokers were analysed. Multinomial logistic regression models examined the relationship among mentholated cigarette smoking, risk perceptions and current flavoured LCC use for the analytic sample and gender and race/ethnicity. Daily menthol cigarette smokers, compared to occasional, non-menthol smokers, had increased odds of flavoured LCC smoking (OR=1.75, 95% CI 1.02 to 2.98). This relationship was found for males, blacks/African-Americans and Hispanics/Latinos (psmokers, specifically those from vulnerable populations. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Bioenergy. A sustainable and reliable energy source. A review of status and prospects. Executive Summary

International Nuclear Information System (INIS)

Bauen, A.; Vuille, F.; Berndes, G.; Junginger, M.; Londo, M.

2009-08-01

This publication is the Executive Summary of a report prepared for IEA Bioenergy. The full report 'Bioenergy - a Sustainable and Reliable Energy Source' will be available on the website of IEA Bioenergy in digital form and in hard copy in a few months time. The purpose of the project was to produce an authoritative review of the entire bioenergy sector aimed at policy and investment decision makers. The brief to the contractors was to provide a global perspective of the potential for bioenergy, the main opportunities for deployment in the short and medium term and the principal issues and challenges facing the development of the sector.

High-Impact Succession Management. Executive Summary

Science.gov (United States)

Lamoureux, Kim; Campbell, Michael; Smith, Roland

2009-01-01

Most companies have an opportunity to improve their succession management programs. The number one challenge for succession management (as identified by both HR leaders and executives) is developing a succession planning strategy. This comprehensive industry study sets out to determine how succession management (when done well) helps improve…

Summary

International Nuclear Information System (INIS)

2004-01-01

The fourth workshop of the OECD/NEA Forum on Stakeholder Confidence (FSC) was hosted by ONDRAF/NIRAS, the Belgian Agency for Radioactive Waste Management and enriched fissile materials. The central theme of the workshop was ''Dealing with interests, values and knowledge in managing risk''within the Belgian context of local partnerships for the long term management of low-level, short-lived radioactive waste. The four-day workshop started with a half-day session in Brussels giving a general introduction on the Belgian context and the local partnership methodology. This was followed by community visits to three local partnerships, PaLoFF in Fleurus-Farciennes, MONA in Mol, and STOLA in Dessel. After the visits, the workshop continued with two full-day sessions in Brussels. One hundred and nineteen registered participants, representing 13 countries, attended the workshop or participated in the community visits. About two thirds were Belgian stakeholders; the remainder came from FSC member organisations. The participants included representatives of municipal governments, civil society organisations, government agencies, industrial companies, the media, and international organisations as well as private citizens, consultants and academics. This Executive Summary gives an overview of the presentations and discussions that took place at the workshop and the community visits. The structure of the Executive Summary follows the structure of the workshop itself. Complementary to this Executive Summary and also provided with this document, is a NEA Secretariat's reflection aiming to place the main lessons of the workshop into an international perspective. (author)

Findings from the Evaluation of the National Library Power Program. Executive Summary. An Initiative of the DeWitt Wallace-Reader's Digest Fund.

Science.gov (United States)

Zweizig, Douglas; Hopkins, Dianne McAfee

This document presents the executive summary of an evaluation of Library Power, a program of the DeWitt Wallace-Reader's Digest Fund to enhance and elevate the role of libraries in public schools. The report begins with an examination of Library Power's core components (collection development, facilities refurbishing, flexible scheduling,…

Summary information report

International Nuclear Information System (INIS)

1982-07-01

The Summary Information Report (SIR) provides summary data concerning NRC and its licensees for general use by the Chairman, other Commissioners and Commission staff offices, the Executive Director for Operations, and the Office Directors. SIR is published quarterly by the Management Information Branch (49-27834) of the Office of Resource Management

Thermal grill-evoked sensations of heat correlate with cold pain threshold and are enhanced by menthol and cinnamaldehyde.

Science.gov (United States)

Averbeck, B; Rucker, F; Laubender, R P; Carr, R W

2013-05-01

Thunberg's thermal grill produces a sensation of strong heat upon skin contact with spatially interlaced innocuous warm and cool stimuli. To examine the classes of peripheral axons that might contribute to this illusion, the effects of topical l-menthol, an activator of TRPM8, and cinnamaldehyde, a TRPA1 agonist, on the magnitude of thermal sensations were examined during grill stimulation in healthy volunteers. Under control conditions, cutaneous grill stimulation (interlaced 20/40 °C) evoked a sensation of heat, and for individual subjects, the magnitude of this heat sensation was positively correlated with cold pain threshold (CPT). Menthol increased the CPT and enhanced the magnitude of grill-evoked heat. Cinnamaldehyde intensified warm sensations, reduced heat pain threshold and also enhanced grill-evoked heat. Both TRPM8-expressing and TRPA1-expressing afferent axons can affect grill-evoked thermal sensations. The enhancement of grill-evoked sensations of temperature with menthol and cinnamaldehyde may provide an additional clinically relevant means of testing altered thermal sensitivity, which is often affected in neuropathic patient groups. © 2012 European Federation of International Association for the Study of Pain Chapters.

Assessment of research needs for advanced heterogeneous catalysts for energy applications. Final report: Volume 1, Executive summary

Energy Technology Data Exchange (ETDEWEB)

Mills, G.A.

1994-04-01

This report assesses the direction, technical content, and priority of research needs judged to provide the best chance of yielding new and improved heterogeneous catalysts for energy-related applications over a period of 5--20 years. It addresses issues of energy conservation, alternate fuels and feedstocks, and the economics and applications that could alleviate pollution from energy processes. Recommended goals are defined in 3 major, closely linked research thrusts: catalytic science, environmental protection by catalysis, and industrial catalytic applications. This volume provides a comprehensive executive summary, including research recommendations.

An Analysis of the Relationship between English Language Arts and Mathematics Achievement and Essential Learning Mastery in Grades 3 and 4. Executive Summary

Science.gov (United States)

Haystead, Mark W.

2016-01-01

Over several years, Clark Pleasant Community School Corporation (CPCSC) schools have dedicated significant professional development hours and time to develop Essential Learnings (ELs) along with proficiency scales that could guide the content of classroom assessments used to determine student mastery. This executive summary highlights key findings…

77 FR 54570 - Senior Executive Service Performance Review Board

Science.gov (United States)

2012-09-05

... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Senior Executive Service Performance Review Board AGENCY... the Defense Nuclear Facilities Safety Board (DNFSB) Senior Executive Service (SES) Performance Review.... The PRB shall review and evaluate the initial summary rating of the senior executive's performance...

Developing maintainability for tokamak fusion power systems. Phase II report. Volume I: executive summary

International Nuclear Information System (INIS)

Fuller, G.M.; Zahn, H.S.; Mantz, H.C.; Kaletta, G.R.; Waganer, L.M.; Carosella, L.A.; Conlee, J.L.

1978-11-01

The purpose of this report is to identify design features of fusion power reactors which contribute to the achievement of high levels of maintainability. Volume 1, the Executive Summary, presents the progress achieved toward this objective in this phase and includes a comparison with the results of the first phase study efforts. A series of maintainability design guidelines and an improved maintenance system are defined as initial steps in developing the requirements for a maintainable tokamak fusion power system. The principle comparative studies that are summarized include the determination of the benefits of various vacuum wall arrangements, the effect of unscheduled and scheduled maintenance of the first wall/blanket, some initial investigation of maintenance required for subsystems other than the first wall/blanket, and the impact of maintenance equipment failures

How Many Dentists Are Needed in 2040: Executive Summary.

Science.gov (United States)

Bailit, Howard L

2017-08-01

Five background articles in Section 2 of the "Advancing Dental Education in the 21 st Century" project examined some of the factors likely to impact the number of dentists needed in 2040: 1) the oral health of the population, 2) changes in the utilization of dental services, 3) new technologies, 4) the growth of large capitated dental group practices, and 5) the demand for dental care. With this information, a sixth background article estimated the number of dentists needed in 2040 compared to the number expected if current trends continue. This executive summary provides an overview of findings from these six articles. The data indicate major improvements in oral health, especially in upper income groups that account for 65% of practice revenues. At the same time, per capita utilization of restorative and prosthetic services has declined dramatically. No major new technologies are likely to impact the need for dentists by 2040. In a large capitated group practice, full-time general dentists treated an average of 2,100 patients per year; solo general dentists averaged 1,350. Based on the examined factors, growth in demand for traditional forms of care may slow substantially, raising the potential for a surplus of dentists in 2040. If these trends continue, the key national policy issue then would be: should schools reduce the number of graduates before market forces require them to downsize or close, or are other alternatives available?

Critical human-factors issues in nuclear-power regulation and a recommended comprehensive human-factors long-range plan. Executive summary

International Nuclear Information System (INIS)

Hopkins, C.O.; Snyder, H.L.; Price, H.E.; Hornick, R.J.; Mackie, R.R.; Smillie, R.J.; Sugarman, R.C.

1982-08-01

This comprehensive long-range human factors plan for nuclear reactor regulation was developed by a Study Group of the Human Factors Society, Inc. This Study Group was selected by the Executive Council of the Society to provide a balanced, experienced human factors perspective to the applications of human factors scientific and engineering knowledge to nuclear power generation. The report is presented in three volumes. Volume 1 contains an Executive Summary of the 18-month effort and its conclusions. Volume 2 summarizes all known nuclear-related human factors activities, evaluates these activities wherever adequate information is available, and describes the recommended long-range (10-year) plan for human factors in regulation. Volume 3 elaborates upon each of the human factors issues and areas of recommended human factors involvement contained in the plan, and discusses the logic that led to the recommendations

Oral L-menthol reduces thermal sensation, increases work-rate and extends time to exhaustion, in the heat at a fixed rating of perceived exertion.

Science.gov (United States)

Flood, T R; Waldron, M; Jeffries, O

2017-07-01

The study investigated the effect of a non-thermal cooling agent, L-menthol, on exercise at a fixed subjective rating of perceived exertion (RPE) in a hot environment. Eight male participants completed two trials at an exercise intensity between 'hard' and 'very hard', equating to 16 on the RPE scale at ~35 °C. Participants were instructed to continually adjust their power output to maintain an RPE of 16 throughout the exercise trial, stopping once power output had fallen by 30%. In a randomized crossover design, either L-menthol or placebo mouthwash was administered prior to exercise and at 10 min intervals. Power output, [Formula: see text]O 2 , heart rate, core and skin temperature was monitored, alongside thermal sensation and thermal comfort. Isokinetic peak power sprints were conducted prior to and immediately after the fixed RPE trial. Exercise time was greater (23:23 ± 3:36 vs. 21:44 ± 2:32 min; P = 0.049) and average power output increased (173 ± 24 vs. 167 ± 24 W; P = 0.044) in the L-menthol condition. Peak isokinetic sprint power declined from pre-post trial in the L-menthol l (9.0%; P = 0.015) but not in the placebo condition (3.4%; P = 0.275). Thermal sensation was lower in the L-menthol condition (P = 0.036), despite no changes in skin or core temperature (P > 0.05). These results indicate that a non-thermal cooling mouth rinse lowered thermal sensation, resulting in an elevated work rate, which extended exercise time in the heat at a fixed RPE.

A Study of the Extent and Effect of English Language Training for Refugees. Phase One: Results of a Comprehensive Mail Survey. Executive Summary.

Science.gov (United States)

Northwest Regional Educational Lab., Portland, OR. Office of Research and Evaluation Services.

Results of a national survey of regional, state, and local agencies administering English language training programs for refugees, the first phase of a larger study of the training programs, are reported. The executive summary outlines the responses from 8 regional, 36 state, and 232 local agencies on four topics: (1) the nature and extent of…

Diclofenac systemic bioavailability of a topical 1% diclofenac + 3% menthol combination gel vs. an oral diclofenac tablet in healthy volunteers: a randomized, open-label, crossover study
.

Science.gov (United States)

Moreira, Sebastian A; Liu, D Jeffery

2017-04-01

Evaluate systemic exposure with repeated topical application of a fixed-combination topical gel product containing 1% diclofenac sodium and 3% menthol in either of 2 formulation packages relative to oral administration. In this phase 1, single-center, 4-way crossover study, healthy volunteers aged 18 - 50 years underwent consecutive 3-day treatment regimens in a randomly assigned sequence with each of 4 treatment groups: 4 g of topical 1% diclofenac + 3% menthol gel administered via an aluminum tube or roll-on device applied 4 times daily; 4 g of topical 1% diclofenac sodium gel (Voltaren Gel) applied 4 times daily; and oral diclofenac sodium tablets 50 mg 3 times daily. Treatment regimens were separated by 2-day washout periods. A total of 18 subjects enrolled and completed the study. Relative to oral administration, area under the concentration time curve from 48 to 72 hours (AUC48-72) with topical administration of 1% diclofenac + 3% menthol gel from a tube or roll-on device was 16.1% (90% CI: 12.2 - 21.1%) and 14.4% (90% CI: 11.0 - 19.0%), respectively. The diclofenac/menthol combination delivered significantly higher exposures of diclofenac compared with Voltaren Gel. A higher number of adverse events (AEs) occurred with the topical diclofenac/menthol combination (61%) vs. Voltaren Gel (22%) or oral diclofenac (6%); most were local skin reactions. No difference in systemic AEs was observed among the groups. As expected, systemic exposure was significantly lower with the topical diclofenac/menthol treatment regimens compared with oral diclofenac. Local skin AEs were increased with the topical combination product, but the risk of systemic AEs was low.
.

Reducing barriers to energy efficiency in the German mechanical engineering sector. Executive summary

Energy Technology Data Exchange (ETDEWEB)

Schleich, J.; Boede, U.

2000-12-01

This report describes the empirical research into barriers to energy efficiency in the German mechanical engineering (ME) sector. It is one of nine such reports in the BARRIERS project. The report contains description and analysis of four case studies of energy management in German companies in the ME sector. The results are analysed using the theoretical framework developed for the BARRIERS project. The report also provides brief recommendations on how these barriers to the rational use of energy (RUE) may be overcome and how energy efficiency within the ME sector may be improved. The results of the study for the ME sector in Germany are summarised in this executive summary under the following headings: - Characterising the mechanical engineering sector; - Case studies of energy management in the German mechanical engineering sector; - Evidence of barriers in the German mechanical engineering sector; - The role of energy service companies in the mechanical engineering sector; - Policy implications. (orig.)

Reducing barriers to energy efficiency in the German higher education sector. Executive summary

Energy Technology Data Exchange (ETDEWEB)

Schleich, J.; Boede, U.

2000-12-01

This report describes the empirical research into barriers to energy efficiency in the German higher education (HE) sector. It is one of nine such reports in the BARRIERS project. The report contains description and analysis of six case studies of energy management in German universities. The results are analysed using the theoretical framework developed for the BARRIERS project (Sorrell et al., 2000). The report also provides brief recommendations on how these barriers to the rational use of energy (RUE) may be overcome and how energy efficiency within the sector may be improved. The results of the study for the higher education sector in Germany are summarised in this executive summary under the following headings: - Characterising the higher education sector; - Case studies of energy management in the German higher education sector; - Evidence of barriers in the German higher education sector; - The role of energy service companies in the higher education sector; - Policy implications. (orig.)

Optimization of Microencapsulation Composition of Menthol, Vanillin, and Benzyl Acetate inside Polyvinyl Alcohol with Coacervation Method for Application in Perfumery

Science.gov (United States)

Sahlan, Muhamad; Raihani Rahman, Mohammad

2017-07-01

One of many applications of essential oils is as fragrance in perfumery. Menthol, benzyl acetate, and vanillin, each represents olfactive characteristic of peppermint leaves, jasmine flowers, and vanilla beans, are commonly used in perfumery. These components are highly volatile, hence the fragrance components will quickly evaporate resulting in short-lasting scent and low shelf life. In this research, said components have been successfully encapsulated simultaneously inside Polyvinyl Alcohol (PVA) using simple coacervation method to increase its shelf life. Optimization has been done using Central Composite Diagram with 4 independent variables, i.e. composition of menthol, benzyl acetate, vanillin, and tergitol 15-S-9 (as emulsifier). Encapsulation efficiency, loading capacity, and microcapsule size have been measured. In optimized composition of menthol (13.98 %w/w), benzyl acetate (14.75 %w/w), vanillin (17.84 %w/w), and tergitol 15-S-9 (13.4 %w/w) encapsulation efficiency of 97,34% and loading capacity of 46,46% have been achieved. Mean diameter of microcapsule is 20,24 μm and within range of 2,011-36,24 μm. Final product was achieved in the form of cross linked polyvinyl alcohol with hydrogel consistency and orange to yellow in color.

Inventory of Federal energy-related environment and safety research for FY 1979. Volume 1. Executive summary

International Nuclear Information System (INIS)

1980-12-01

The FY 1979 Federal Inventory contains information on 3506 federally funded energy-related environmental and safety research projects. The Inventory is published in two volumes: Volume I, an executive summary and overview of the data and Volume II, project listings, summaries, and indexes. Research and development (R and D) categories were reorganized into three main areas; environmental and safety control technology, technology impacts overview and assessments, and biological and environmental R and D and assessments. Federal offices submitting project data were: Council on Environmental Quality; Department of Agriculture; Department of Commerce; Department of Defense; Department of Energy; Department of Health, Education, and Welfare; Department of Housing and Urban Development; Department of the Interior; Department of Transportation; Environmental Protection Agency; National Aeronautics and Space Administration; Nuclear Regulatory Commission; National Science Foundation; Office of Technology Assessment; and Tennessee Valley Authority. The inventory also breaks out research sponsored by various federal agencies and the amount of funding provided by each in various research categories. The format and index system allows efficient access to information compiled. Users are able to identify projects by log agency, performing organization, principal investigator and subject

Definition of technology development missions for early Space Station satellite servicing. Volume 1: Executive summary

Science.gov (United States)

1984-01-01

The Executive Summary volume 1, includes an overview of both phases of the Definition of Technology Development Missions for Early Space Station Satellite Servicing. The primary purpose of Phase 1 of the Marshall Space Flight Center (MSFC) Satellite Servicing Phase 1 study was to establish requirements for demonstrating the capability of performing satellite servicing activities on a permanently manned Space Station in the early 1990s. The scope of Phase 1 included TDM definition, outlining of servicing objectives, derivation of initial Space Station servicing support requirements, and generation of the associated programmatic schedules and cost. The purpose of phase 2 of the satellite servicing study was to expand and refine the overall understanding of how best to use the manned space station as a test bed for demonstration of satellite servicing capabilities.

Executive Dysfunction

Science.gov (United States)

Rabinovici, Gil D.; Stephens, Melanie L.; Possin, Katherine L.

2015-01-01

Purpose of Review: Executive functions represent a constellation of cognitive abilities that drive goal-oriented behavior and are critical to the ability to adapt to an ever-changing world. This article provides a clinically oriented approach to classifying, localizing, diagnosing, and treating disorders of executive function, which are pervasive in clinical practice. Recent Findings: Executive functions can be split into four distinct components: working memory, inhibition, set shifting, and fluency. These components may be differentially affected in individual patients and act together to guide higher-order cognitive constructs such as planning and organization. Specific bedside and neuropsychological tests can be applied to evaluate components of executive function. While dysexecutive syndromes were first described in patients with frontal lesions, intact executive functioning relies on distributed neural networks that include not only the prefrontal cortex, but also the parietal cortex, basal ganglia, thalamus, and cerebellum. Executive dysfunction arises from injury to any of these regions, their white matter connections, or neurotransmitter systems. Dysexecutive symptoms therefore occur in most neurodegenerative diseases and in many other neurologic, psychiatric, and systemic illnesses. Management approaches are patient specific and should focus on treatment of the underlying cause in parallel with maximizing patient function and safety via occupational therapy and rehabilitation. Summary: Executive dysfunction is extremely common in patients with neurologic disorders. Diagnosis and treatment hinge on familiarity with the clinical components and neuroanatomic correlates of these complex, high-order cognitive processes. PMID:26039846

Housing Operations Management System (HOMES). Volume 1. Executive Summary

Science.gov (United States)

1984-08-01

output products become available. One of these products is the Reimburs - able Order and Contract Ledger. By entering a Reimbursable Order (RO) Number or...Development Products Menu 108 G8 HOMES Budget Execution Menu 109 G9 Budget Execution Flow 110 G1O Commitments and Obligations Ledger il1 Gil Reimbursable ...are in a specified percentage range liquidated. Figure ClI shows the format of the Reimbursable Order and Contract Ledger. Figure 012 shows the

Comprehensive risk reduction in patients with atrial fibrillation : Emerging diagnostic and therapeutic options Executive summary* of the report from the 3rd AFNET/EHRA consensus conference

NARCIS (Netherlands)

Kirchhof, Paulus; Lip, Gregory Y. H.; Van Gelder, Isabelle C.; Bax, Jeroen; Hylek, Elaine; Kaeaeb, Stefan; Schotten, Ulrich; Wegscheider, Karl; Boriani, Giuseppe; Ezekowitz, Michael; Diener, Hans; Heidbuchel, Hein; Lane, Deirdre; Mont, Luis; Willems, Stephan; Dorian, Paul; Vardas, Panos; Breithardt, Guenter; Camm, A. John

2011-01-01

There are exciting new developments in several areas of atrial fibrillation (AF) management that carry the hope of improving outcomes in AF patients. This paper is an executive summary that summarises the proceedings from the 3rd AFNET/EHRA consensus conference on atrial fibrillation, held in Sophia

Oral Health Research and Scholarship in 2040: Executive Summary.

Science.gov (United States)

Polverini, Peter J

2017-09-01

This executive summary for Section 6 of the "Advancing Dental Education in the 21 st Century" project provides an overview of five background articles that address the role of research and scholarship in dental education in the year 2040. Beginning with a historical account of research and discovery science in dentistry's evolution as a profession, the article then reviews the role of early thought leaders and organized dentistry in establishing research as a cornerstone of dental education and dental practice. The dental research workforce faces an uncertain future fueled by a volatile funding environment and inadequate mentoring and training of research faculty. Dental schools must forge stronger academic and scientific ties to their university and academic health centers and will be challenged to develop sustainable research and patient care collaborations with other health professions. The changing health care environment will create new opportunities for oral health care providers to expand their scope of practice and focus on prevention and screening for non-communicable chronic diseases. Dental practitioners in the future are likely to place greater emphasis on managing the overall health of their patients while promoting closer integration with other health professionals. All dental schools must develop a sustainable research mission if they hope to graduate dentists who function effectively in a collaborative health care environment. The changing scientific and health care landscape will dramatically alter dental education and dental practice. Dental schools need to reconsider their research and educational priorities and clinical practice objectives. Until dental schools and the practicing community come to grips with these challenges, a persistent attitude of complacency will likely be at the dental profession's peril.

76 FR 61726 - Senior Executive Service Performance Review; Correction

Science.gov (United States)

2011-10-05

... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary Senior Executive Service Performance Review; Correction AGENCY: Office of the Secretary, DHS. ACTION: Notice; correction. SUMMARY: The... the appointment of the members of the Senior Executive Performance Review Boards. This correction adds...

Nuclear Energy Innovation Workshops. Executive Summary

Energy Technology Data Exchange (ETDEWEB)

Allen, Todd [Idaho National Lab. (INL), Idaho Falls, ID (United States); Jackson, John [Idaho National Lab. (INL), Idaho Falls, ID (United States); Hildebrandt, Phil [Idaho National Lab. (INL), Idaho Falls, ID (United States); Baker, Suzy [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-06-01

The nuclear energy innovation workshops were organized and conducted by INL on March 2-4, 2015 at the five NUC universities and Boise State University. The output from these workshops is summarized with particular attention to final summaries that were provided by technical leads at each of the workshops. The current revision includes 3-4 punctuation corrections and a correction of the month of release from May to June.

Executive summary and conclusions from the European Hydration Institute Expert Conference on human hydration, health, and performance.

Science.gov (United States)

Benton, D; Braun, H; Cobo, J C; Edmonds, C; Elmadfa, I; El-Sharkawy, A; Feehally, J; Gellert, R; Holdsworth, J; Kapsokefalou, M; Kenney, W L; Leiper, J B; Macdonald, I A; Maffeis, C; Maughan, R J; Shirreffs, S M; Toth-Heyn, P; Watson, P

2015-09-01

On April 7-8, 2014, the European Hydration Institute hosted a small group of experts at Castle Combe Manor House, United Kingdom, to discuss a range of issues related to human hydration, health, and performance. The meeting included 18 recognized experts who brought a wealth of experience and knowledge to the topics under review. Eight selected topics were addressed, with the key issues being briefly presented before an in-depth discussion. Presented here is the executive summary and conclusions from this meeting. © The Author(s) 2015. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

MOD-5A wind turbine generator program design report: Volume 1: Executive Summary

Science.gov (United States)

1984-01-01

The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator covering work performed between July 1980 and June 1984 is discussed. The report is divided into four volumes: Volume 1 summarizes the entire MOD-5A program, Volume 2 discusses the conceptual and preliminary design phases, Volume 3 describes the final design of the MOD-5A, and Volume 4 contains the drawings and specifications developed for the final design. Volume 1, the Executive Summary, summarizes all phases of the MOD-5A program. The performance and cost of energy generated by the MOD-5A are presented. Each subsystem - the rotor, drivetrain, nacelle, tower and foundation, power generation, and control and instrumentation subsystems - is described briefly. The early phases of the MOD-5A program, during which the design was analyzed and optimized, and new technologies and materials were developed, are discussed. Manufacturing, quality assurance, and safety plans are presented. The volume concludes with an index of volumes 2 and 3.

Annual report and summary financial statement 1990-1991

International Nuclear Information System (INIS)

1992-01-01

The 1990-1991 Annual Report for Scottish Hydro-Electric PLC includes their rotating territory in Scotland, details of the Board of Directors, the Chairman's Statement, the chief Executive's Review of Operations, a summary profit and loss account, a summary balance sheet and a summary financial statement. (UK)

76 FR 61346 - Senior Executive Service Performance Review Board

Science.gov (United States)

2011-10-04

... DEPARTMENT OF DEFENSE Office of the Secretary Senior Executive Service Performance Review Board AGENCY: Department of Defense Office of Inspector General, Department of Defense (DoD). ACTION: Notice. SUMMARY: This notice announces the appointment of the members of the Senior Executive Service (SES...

Energy from the desert. Very large scale photovoltaic systems: socio-economic, financial, technical and environmental aspects. Executive summary

Energy Technology Data Exchange (ETDEWEB)

Kurokawa, K.; Ito, M.; Komoto, K.; Vleuten, P. van der; Faiman, D. (eds.)

2009-05-15

This executive summary report for the International Energy Agency (IEA) summarises the objectives and concepts of very large scale photovoltaic power generation (VLS-PV) systems and takes a look at the socio-economic, financial and technical aspects involved as well as the environmental impact of such systems. Potential benefits for desert communities, agricultural development and desalination of water are topics that are looked at. The potential of VLS-PV, its energy payback time and CO{sub 2} emission rates are discussed. Case studies for the Sahara and the Gobi Dessert areas are discussed. A VLS-PV roadmap is proposed and scenarios are discussed. Finally, conclusions are drawn and recommendations are made.

Executive summary

International Nuclear Information System (INIS)

2002-01-01

systems. The scope of the workshop comprised reactor physics, fuel performance and fuel material technology, thermal-hydraulics, core behaviour and fuel cycle of advanced reactors with different types of fuels or fuel lattices. Reactor types considered were water-cooled, high-temperature gas-cooled and fast spectrum reactors as well as hybrid reactors with fast and thermal neutron spectra. The emphasis was on innovative concepts and issues related to the reactor and fuel. The workshop concluded with a wide-ranging panel discussion which considered some difficult questions from which it is hoped that some recommendations for future priorities can be derived. A record of the discussion is included at the end of this summary. (author)

Constellation Program: Lessons Learned. Volume 1; Executive Summary

Science.gov (United States)

Rhatigan, Jennifer L. (Editor)

2011-01-01

This document (Volume I) provides an executive summary of the lessons learned from the Constellation Program. A companion Volume II provides more detailed analyses for those seeking further insight and information. In this volume, Section 1.0 introduces the approach in preparing and organizing the content to enable rapid assimilation of the lessons. Section 2.0 describes the contextual framework in which the Constellation Program was formulated and functioned that is necessary to understand most of the lessons. Context of a former program may seem irrelevant in the heady days of new program formulation. However, readers should take some time to understand the context. Many of the lessons would be different in a different context, so the reader should reflect on the similarities and differences in his or her current circumstances. Section 3.0 summarizes key findings developed from the significant lessons learned at the program level that appear in Section 4.0. Readers can use the key findings in Section 3.0 to peruse for particular topics, and will find more supporting detail and analyses in Section 4.0 in a topical format. Appendix A contains a white paper describing the Constellation Program formulation that may be of use to readers wanting more context or background information. The reader will no doubt recognize some very similar themes from previous lessons learned, blue-ribbon committee reviews, National Academy reviews, and advisory panel reviews for this and other large-scale human spaceflight programs; including Apollo, Space Shuttle, Shuttle/Mir, and the ISS. This could represent an inability to learn lessons from previous generations; however, it is more likely that similar challenges persist in the Agency structure and approach to program formulation, budget advocacy, and management. Perhaps the greatest value of these Constellation lessons learned can be found in viewing them in context with these previous efforts to guide and advise the Agency and its

2nd FSC Workshop - Executive Summary and International Perspective, Stakeholder Involvement and Confidence in the Process of Decision-making for the Disposal of Spent Nuclear Fuel in Finland, 15-16 November 2001, Turku, Finland

International Nuclear Information System (INIS)

2002-01-01

The 2. FSC workshop examined 'Stakeholder Involvement and Confidence in the Process of Decision-making for the Disposal of Spent Nuclear Fuel in Finland'. By gathering Finnish Stakeholders, those who expressed favour and opposition, as well as observer-participants from the other NEA/FSC countries, a joint reflection on a complex reality was achieved from which general conclusions can also be drawn concerning stakeholder involvement in the long-term management of radioactive waste. This Executive Summary gives an overview of the presentations and discussions that took place at the workshop. It presents, for the most part, a factual account of the individual presentations and of the discussions that took place. It relies importantly on the notes that were taken at the meeting. Most materials are elaborated upon in a fuller way in the texts that the various speakers and session moderators contributed for these proceedings. The structure of the Executive Summary follows the structure of the workshop itself. Complementary to this Executive Summary and also provided with this document, is a NEA Secretariat's perspective aiming to place the results of all discussions, feedback and site visit into an international perspective

Effects of menthol essence and breast milk on the improvement of nipple fissures in breastfeeding women

Directory of Open Access Journals (Sweden)

Sedigheh Amir Ali Akbari

2014-01-01

Full Text Available Background: Nipple fissure is a common disorder during breastfeeding. With high prevalence of nipple fissures and its impacts on breastfeeding, as well as the existence of evidence in favor of the application of peppermint as an antiinflammatory and antiinfection herb, the purpose of this study is to determine the effect of Menthol essence on improving nipple fissures in the primiparous breastfeeding women. Materials and Methods: This study was conducted using a clinical trial method. Samples were divided randomly into two groups of 55 women. The women in the peppermint group applied four drops of Menthol essence on their nipple and areola after each feeding. The control group applied four drops of their own milk on the nipple and areola after each feeding. Then, the two groups were studied on days 10 and 14 postpartum. For intensity of pain, the visual analog scale (0-10 cm and to measure the severity of damage, Amir scale (1-10 cm were applied and the existence or lack of nipple discharge was also recorded. The data were analyzed using SPSS 17 software. Results: The mean intensity of pain and nipple fissure before treatment (8.55 ± 1.74 and day 10 after delivery (4.26 ± 1.57 and before treatment and day 14 after delivery in the case group (1.32 ± 1.02 had a significant difference (P < 0.001. Nipple discharge between the two groups, before treatment (%75.2 and day 10 after delivery (%31.6 and before treatment and day 14 after delivery (%15.7, the case group had a significant difference (P < 0.001. Conclusion: Menthol essence can improve nipple fissures in the primiparous breastfeeding women.

Puerarin transport across rat nasal epithelial cells and the influence of compatibility with paeoniflorin and menthol

Directory of Open Access Journals (Sweden)

Zhang L

2017-09-01

Full Text Available Lin Zhang, Shou-Ying Du, Yang Lu, Chang Liu, Hui-Chao Wu, Zhi-Hao Tian, Min Wang, Chang Yang School of Chinese Materia Medica, Beijing University of Chinese Medicine, Chaoyang District, Beijing, People’s Republic of China Abstract: Nose-to-brain transport can provide an excellent pathway for drugs of the central nervous system. Consequently, how to make full use of this pathway in practical applications has become a focus of drug design. However, many aspects affecting drug delivery from the nose to the brain remain unclear. This study aimed to more deeply investigate the transport of puerarin and to explore the mechanism underlying the influence of compatible drugs on puerarin permeability in a primary cell model simulating the nasal mucosa. In this research, based on rat nasal epithelial cells (RNECs cultured in vitro and cytotoxicity assays, the bidirectional transport of puerarin across RNEC monolayers and the effect of its compatibility with peoniflorin and menthol were analyzed. The apparent permeability coefficient was <1.5×10–6 cm/s, and the efflux ratio of puerarin was <2, indicating that puerarin had poor absorption and that menthol but not peoniflorin significantly improved puerarin transport. Simultaneously, through experiments, such as immunofluorescence staining, transepithelial electrical resistance measurement, rhodamine 123 efflux evaluation, the cell membrane fluorescence recovery after photobleaching test, and ATPase activity determination, the permeability promoting mechanism of menthol was confirmed to be closely related to disruption of the tight junction protein structure, to the P-glycoprotein inhibitory effect, to increased membrane fluidity, and to the promotion of enzyme activity. These results provide reliable data on nasal administration of the studied drugs and lay the foundation for a deeper investigation of the nose–brain pathway and nasal administration. Keywords: Chinese herbal compound

Executive Summary

International Nuclear Information System (INIS)

2013-01-01

countries (MC) and concerned both initial safety assessment of new facilities and reassessment of existing ones (periodic safety review). It also considered trends of future improvement of safety assessment techniques. The workshop was organised in an opening session, four technical sessions, one special session and a conclusion session. The technical sessions were focussed on: - General approach including human aspects (9 papers); - Front end facilities (5 papers); - Chemical hazards - release limits (6 papers); and - Back end facilities (6 papers). In addition, a special session (4 presentations) was held to discuss the lessons learnt for FCFs from the Fukushima accident in Japan. The workshop ended with an organized site visit to Cameco Corporation's Port Hope Conversion Facility in Port Hope, Ontario on the last day of the workshop. This paper presents the Summary of the technical and special sessions, the General Conclusions and Recommendation of the workshop and some future directions

What Should Oral Health Professionals Know in 2040: Executive Summary.

Science.gov (United States)

Weintraub, Jane A

2017-08-01

The "Advancing Dental Education in the 21 st Century" project assesses current status and trends to prepare for the future. Section 3 of the project asks what knowledge and skills should dental and advanced dental education learners have to provide dental care in 2040 and how should educators be preparing them. This executive summary of five background articles in this section focuses on predoctoral education, advanced dental education, the provision of medical services within dental practice, the incorporation of oral health services into primary care and medical practice, and interprofessional education and practice. The changing environment and external forces are presented along with their implications for advancing dental education. These forces include changes in population characteristics (e.g., demographics, disease prevalence, health disparities, consumerism), treatment needs and modalities, care delivery, science and technology, educational methods, and medical and dental integration. Future oral health professionals (OHPs) will care for more diverse patient populations, older patients with complex medical and dental needs, and relatively dentally healthy younger cohorts who require fewer complex restorative and prosthodontic treatments. Increasing integration of medical and oral health education and patient care will require OHPs to have more medical knowledge and to practice in intra- and interprofessional teams. OHPs increasingly will be providing patient-centered care as employees in large group practices, health care settings, and safety net clinics with expanded types of OHPs and improved materials and technology. Educators need to implement innovative curricula and educational methods to prepare for and adapt to the disruptive changes that lie ahead.

Nicotine, aerosol particles, carbonyls and volatile organic compounds in tobacco- and menthol-flavored e-cigarettes.

Science.gov (United States)

Lee, Mi-Sun; LeBouf, Ryan F; Son, Youn-Suk; Koutrakis, Petros; Christiani, David C

2017-04-27

We aimed to assess the content of electronic cigarette (EC) emissions for five groups of potentially toxic compounds that are known to be present in tobacco smoke: nicotine, particles, carbonyls, volatile organic compounds (VOCs), and trace elements by flavor and puffing time. We used ECs containing a common nicotine strength (1.8%) and the most popular flavors, tobacco and menthol. An automatic multiple smoking machine was used to generate EC aerosols under controlled conditions. Using a dilution chamber, we targeted nicotine concentrations similar to that of exposure in a general indoor environment. The selected toxic compounds were extracted from EC aerosols into a solid or liquid phase and analyzed with chromatographic and spectroscopic methods. We found that EC aerosols contained toxic compounds including nicotine, fine and nanoparticles, carbonyls, and some toxic VOCs such as benzene and toluene. Higher mass and number concentrations of aerosol particles were generated from tobacco-flavored ECs than from menthol-flavored ECs. We found that diluted machine-generated EC aerosols contain some pollutants. These findings are limited by the small number of ECs tested and the conditions of testing. More comprehensive research on EC exposure extending to more brands and flavor compounds is warranted.

Effects of menthol application on the skin during prolonged immersion in swimmers and controls.

Science.gov (United States)

Botonis, P G; Geladas, N D; Kounalakis, S N; Cherouveim, E D; Koskolou, M D

2017-12-01

We hypothesized that menthol application on the skin would enhance vasoconstriction of subjects immersed in cool water, which would reduce heat loss and rectal temperature (Tre) cooling rate. Furthermore, it was hypothesized that this effect would be greater in individuals acclimatized to immersion in 24 °C water, such as swimmers. Seven swimmers (SW) and seven physical education students (CON) cycled at 60% VO 2 max until Tre attained 38 °C, and were then immediately immersed in stirred water maintained at 24 °C on two occasions: without (NM) and with (M; 4.6 g per 100 mL of water) whole-body skin application of menthol cream. Heart rate, Tre, proximal-distal skin temperature gradient, oxygen uptake (VO 2 ), electromyographic activity (EMG), and thermal sensation were measured. Tre reduction was similar among SW and CON in NM and CON in M (-0.71±0.31 °C in average), while it was smaller for SW in M (-0.37±0.18 °C, P immersion reduces heat loss, but defends Tre decline more effectively in swimmers than in non-swimmers. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

78 FR 5516 - Senior Executive Service Performance Review Board Membership

Science.gov (United States)

2013-01-25

... OCCUPATIONAL SAFETY AND HEALTH REVIEW COMMISSION Senior Executive Service Performance Review Board Membership AGENCY: Occupational Safety and Health Review Commission. ACTION: Annual notice. SUMMARY: Notice... established a Senior Executive Service PRB. The PRB reviews and evaluates the initial appraisal of a senior...

75 FR 14214 - Senior Executive Service Performance Review Board Membership

Science.gov (United States)

2010-03-24

... OCCUPATIONAL SAFETY AND HEALTH REVIEW COMMISSION Senior Executive Service Performance Review Board Membership AGENCY: Occupational Safety and Health Review Commission. ACTION: Annual notice. SUMMARY: Notice... established a Senior Executive Service PRB. The PRB reviews and evaluates the initial appraisal of a senior...

76 FR 39926 - Senior Executive Service Performance Review Board Membership

Science.gov (United States)

2011-07-07

... OCCUPATIONAL SAFETY AND HEALTH REVIEW COMMISSION Senior Executive Service Performance Review Board Membership AGENCY: Occupational Safety and Health Review Commission. ACTION: Annual notice. SUMMARY: Notice... established a Senior Executive Service PRB. The PRB reviews and evaluates the initial appraisal of a senior...

76 FR 81998 - Senior Executive Service Performance Review Board Membership

Science.gov (United States)

2011-12-29

... OCCUPATIONAL SAFETY AND HEALTH REVIEW COMMISSION Senior Executive Service Performance Review Board Membership AGENCY: Occupational Safety and Health Review Commission. ACTION: Annual notice. SUMMARY: Notice... established a Senior Executive Service PRB. The PRB reviews and evaluates the initial appraisal of a senior...

Large Deployable Reflector (LDR) system concept and technology definition study. Volume 1: Executive summary, analyses and trades, and system concepts

Science.gov (United States)

Agnew, Donald L.; Jones, Peter A.

1989-01-01

A study was conducted to define reasonable and representative large deployable reflector (LDR) system concepts for the purpose of defining a technology development program aimed at providing the requisite technological capability necessary to start LDR development by the end of 1991. This volume includes the executive summary for the total study, a report of thirteen system analysis and trades tasks (optical configuration, aperture size, reflector material, segmented mirror, optical subsystem, thermal, pointing and control, transportation to orbit, structures, contamination control, orbital parameters, orbital environment, and spacecraft functions), and descriptions of three selected LDR system concepts. Supporting information is contained in appendices.

Southern cone energy network coal gasification for SNG production and pipeline system. Feasibility study. Volume 1. Executive summary. Export trade information

International Nuclear Information System (INIS)

1992-01-01

The Executive Summary document summarizes the study report on the economic and technical feasibility of gasifying coal to produce a substitute natural gas (SNG) for distribution to the industrial areas of Southern Brazil. The report includes data surveys, technology assessments, process evaluations, and conceptual designs and analyses. The study contributes to the Brazilian Government efforts to investigate feasible crude oil substitution programs that will meet the nation's energy needs by utilizing domestic resources, thereby reducing the severe negative impact of foreign crude oil importation on Brazil's balance of payments

DECOVALEX - Mathematical models of coupled T-H-M processes for nuclear waste repositories. Executive summary for Phases I,II and III

International Nuclear Information System (INIS)

Jing, L.; Stephansson, O.; Tsang, C.F.; Kautsky, F.

1996-06-01

This executive summary presents the motivation, structure, objectives, methodologies and results of the first stage of the international DECOVALEX project - DECOVALEX I (1992-1995). The acronym stands for Development of Coupled Models and their Validation against Experiment in Nuclear Waste Isolation, and the project is an international effort to develop mathematical models, numerical methods and computer codes for coupled thermo-hydro-mechanical processes in fractured rocks and buffer materials for geological isolation of spent nuclear fuel and other radioactive wastes, and validate them against laboratory and field experiments. 24 refs

Annual report and summary financial statement 1991-1992

International Nuclear Information System (INIS)

1993-01-01

The 1991-92 Annual Report for Scottish Hydro-Electric PLC is presented. It includes key financial statistics, the financial calendar, details of the Board of Directors, the Chairman's Statement, the Chief Executives' review of operations, operational statistics, a summary financial statement, a summary group profit and loss account, summary balance sheets, the Auditors' Report and a customer map. (UK)

WOCN 2016 Guideline for Prevention and Management of Pressure Injuries (Ulcers): An Executive Summary.

Science.gov (United States)

This article provides an executive summary of recommendations from the 2016 Guideline for Prevention and Management of Pressure Ulcers (Injuries) published by the Wound, Ostomy and Continence Nurses Society (WOCN). It presents an overview of the process used to update and develop the guideline, and lists the specific recommendations from the guideline for assessment, prevention, and treatment of pressure injuries. The guideline is a resource for physicians, nurses, therapists, and other healthcare professionals who work with adults who have/or are at risk for pressure injuries. The full text of the published guideline, which includes the available evidence supporting the recommendations and a complete reference list, is available from the Wound, Ostomy and Continence Nurses Society, 1120 Rt 73, Ste 200, Mount Laurel, NJ 08054; Web site: www.wocn.org. Refer to the Supplemental Digital Content (http://links.lww.com/JWOCN/A38) associated with this article for a complete reference list for the guideline. The guideline has been accepted for inclusion in the National Guideline Clearinghouse (www.guideline.gov/).

Summon Post Implementation Interviews Study - Executive Summary

KAUST Repository

Ramli, Rindra M.

2017-01-01

This executive report summarizes the interview findings on the use of Summon by our community. Summon is the library's new webscale discovery layer that was launched in May 2016. The findings highlighted that Google Scholar remains the popular resource to search for articles. In addition to that, library website (Koral / Summon) is commonly used to search for known items such as book / electronic book titles. The report also includes the author's short and long term recommendations to address the shortcomings of the present situation.

Summon Post Implementation Interviews Study - Executive Summary

KAUST Repository

Ramli, Rindra M.

2017-04-12

This executive report summarizes the interview findings on the use of Summon by our community. Summon is the library\\'s new webscale discovery layer that was launched in May 2016. The findings highlighted that Google Scholar remains the popular resource to search for articles. In addition to that, library website (Koral / Summon) is commonly used to search for known items such as book / electronic book titles. The report also includes the author\\'s short and long term recommendations to address the shortcomings of the present situation.

Summary Information report. Vol. 2, No. 3

International Nuclear Information System (INIS)

1983-08-01

The Summary Information Report (SIR) provides summary data concerning NRC and its licensees for general use by the Chairman, other Commissioners and Commission staff offices, the Executive Director for Operations, and the Office Directors. SIR is published quarterly by the Management Information Branch (49-27834) of the Office of Resource Management

Danubian lowland - ground water model. Final Report. Vol. 1. Summary Report

International Nuclear Information System (INIS)

1995-12-01

The summary report contains the next parts: (0) Executive summary; (1) Introduction; (2) Project staffing; (3) Project management issues; (4) Establishment of the integrated modelling system; (5) Summary of model application; (6) Conclusions and recommendations; and List of references

The energy accounts for the Nova Scotia genuine progress index : executive summary

International Nuclear Information System (INIS)

Lipp, J.; Cain, S.; Colman, R.; Parmenter, R.; Milne, K.; Mullaly, H.; Wysocki, A.

2005-10-01

GPI Atlantic has developed a Genuine Progress Index (GPI) involving a new measure of sustainability, wellbeing and quality of life in order to better evaluate energy supply and demand by accounting for all benefits and costs including natural capital, social capital, human capital, and conventional produced capital. The executive summary provides an energy overview and presents indicators of energy sustainability including socio-economic, health and environmental and institutional indicators. Socio-economic indicators are organized across the following 6 areas of concern: reliability, affordability, employment; energy efficiency, energy consumption; and energy production and supply. Health and environmental trends examined include carbon monoxide; nitrogen oxide; sulphur dioxide; mercury; total particulate matter; volatile organic compounds; and greenhouse gas emissions. Trends over time are assessed to determine if energy use is becoming more or less sustainable. Institutional indicators are grouped according to several areas of concern, such as leading by example; creating societal change; reporting; and evaluation. The full cost of energy was then discussed using the underlying physical indicators. It was concluded that Nova Scotia is not making sufficient progress towards sustainability in its energy system, and that the production and use of energy are the leading causes of a number of serious environmental problems. Several recommendations are made for government to lead on a number of initiatives. 4 tabs

A REPRINT of a July 1991 Report to Congress, Executive Summary of Verification of Nuclear Warhead Dismantlement and Special Nuclear Material Controls

International Nuclear Information System (INIS)

Fuller, James L.

2008-01-01

With the renewed thinking and debate about deep reductions in nuclear weapons, including recent proposals about eliminating nuclear warheads altogether, republishing the general conclusions of the Robinson Committee Report of 1992 appears useful. The report is sometimes referred to as the 3151 Report, from Section 3151 of the National Defense Authorization Act for FY1991, from where its requirement originated. This report contains the Executive Summary only and the forwarding letters from the Committee, the President of the United States, the Secretary of Energy, and C Paul Robinson, the head of the Advisory Committee

75 FR 60864 - Senior Executive Service Combined Performance Review Board (PRB)

Science.gov (United States)

2010-10-01

... DEPARTMENT OF THE TREASURY United States Mint Senior Executive Service Combined Performance Review Board (PRB) AGENCY: United States Mint, Department of the Treasury. ACTION: Notice. SUMMARY: Pursuant to... career senior executives below the level of bureau head and principal deputy in the bureaus, except for...

A Market Assessment of Residential Grid-Tied PV Systems in Colorado: Executive Summary

Energy Technology Data Exchange (ETDEWEB)

Farhar, B.; Coburn, T.

2000-09-13

This is the Executive Summary of a report that presents research done in response to a decision by the Colorado Governor's Office of Energy Conservation and Management (OEC) and Colorado utility companies to consider making residential grid-tied photovoltaic (PV) systems available in Colorado. The idea was to locate homeowners willing to pay the costs of grid-tied PV (GPV) systems without batteries--$8,000 or $12,000 for a 2- or 3-kilowatt (kW) system, respectively, in 1996. These costs represented two-thirds of the actual installed cost of $6 per watt at that time and assumed the remainder would be subsidized. The National Renewable Energy Laboratory (NREL) and OEC partnered to conduct a market assessment for GPV technology in Colorado. The study encompassed both qualitative and quantitative phases. The market assessment concluded that a market for residential GPV systems exists in Colorado today. That market is substantial enough for companies to successfully market PV systems to Colorado homeowners. These homeowners appear ready to learn more, inform themselves, and actively purchase GPV systems. The present situation is highly advantageous to Colorado's institutions--primarily its state government and its utility companies, and also its homebuilders--if they are ready to move forward on GPV technology.

Report to the Congress on the need for, and the feasibility of, establishing a security agency within the Office of Nuclear Material Safety and Safeguards. Executive summary

International Nuclear Information System (INIS)

1976-08-01

The Executive Summary of a report written in response to the Congressional mandate Section 204(b)-(2) (c) of the Energy Reorganization Act of 1974, by the Director of the Office of Nuclear Material Safety and Safeguards, U.S. Nuclear Regulatory Commission (NRC) is given. It summarizes the main report, which assessed guard force effectiveness, and addressed public policy, administration and legal issues

Executive summary

International Nuclear Information System (INIS)

2009-01-01

assessment process, licensee actions, regulatory actions. Summaries from the three days of workshop discussions as well as information from the licensee and regulatory responses to two pre-workshop surveys are presented. Also included are highlights from the numerous invited presentations. The conclusions and findings from the extensive group and plenary discussions are summarised too. Supporting material, discussion group presentation slides, slides from the invited presenters, and information/responses to the licensee and regulatory surveys are included in the attached Appendices

Danubian lowland - ground water model. Final Report. Vol. 1. Summary Report

Energy Technology Data Exchange (ETDEWEB)

Danish Hydraulic Inst. (DK); BV, DHV Consultants [NL; TNO, Inst. of Applied Geoscience (NL); Water Quality Institute (DK); Krueger, I [DK; The Royal Veterinary and Agricultural Univ. (DK); Water Resources Research Institute (SK); Research Institute of Irrigation (SK); Consulting Ltd, Ground Water [SK; Faculty of Natural Sciences, Comenius Univ. (SK)

1995-12-01

The summary report contains the next parts: (0) Executive summary; (1) Introduction; (2) Project staffing; (3) Project management issues; (4) Establishment of the integrated modelling system; (5) Summary of model application; (6) Conclusions and recommendations; and List of references. Contains several maps in the parts. figs, tabs, 146 refs.

Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations

Directory of Open Access Journals (Sweden)

Benham Christopher D

2006-03-01

Full Text Available Abstract Background The recent identification of the cold-menthol sensory receptor (TRPM8; CMR1, provides us with an opportunity to advance our understanding of its role in the pathophysiology of bladder dysfunction, and its potential mediation of the bladder cooling reflex. In this study, we report the distribution of the cool and menthol receptor TRPM8 in the urinary bladder in patients with overactive and painful bladder syndromes, and its relationship with clinical symptoms. Methods Bladder specimens obtained from patients with painful bladder syndrome (PBS, n = 16, idiopathic detrusor overactivity (IDO, n = 14, and asymptomatic microscopic hematuria (controls, n = 17, were immunostained using specific antibodies to TRPM8; nerve fibre and urothelial immunostaining were analysed using fibre counts and computerized image analysis respectively. The results of immunohistochemistry were compared between the groups and correlated with the Pain, Frequency and Urgency scores. Results TRPM8-immunoreactive staining was observed in the urothelium and nerve fibres scattered in the suburothelium. The nerve fibre staining was seen in fine-calibre axons and thick (myelinated fibres. There was marked increase of TRPM8-immunoreactive nerve fibres in IDO (P = 0.0249 and PBS (P Conclusion This study demonstrates increased TRPM8 in nerve fibres of overactive and painful bladders, and its relationship with clinical symptoms. TRPM8 may play a role in the symptomatology and pathophysiology of these disorders, and may provide an additional target for future overactive and painful bladder pharmacotherapy.

Ethanol inhibits cold-menthol receptor TRPM8 by modulating its interaction with membrane phosphatidylinositol 4,5-bisphosphate

Czech Academy of Sciences Publication Activity Database

Benedikt, Jan; Teisinger, Jan; Vyklický st., Ladislav; Vlachová, Viktorie

2007-01-01

Roč. 100, č. 1 (2007), s. 211-224 ISSN 0022-3042 R&D Projects: GA ČR GA305/06/0319; GA ČR GA309/04/0496; GA MŠk 1M0517; GA MŠk LC554 Institutional research plan: CEZ:AV0Z50110509 Keywords : Cold /menthol receptor * ethanol * phosphatidylinositol Subject RIV: ED - Physiology Impact factor: 4.451, year: 2007

Institut de recherche sur la fusion par confinement magnetique. Association EURATOM-CEA. Annual report 2008 (executive summary)

International Nuclear Information System (INIS)

2008-01-01

The 2008 experimental campaign on Tore-Supra has been especially fruitful with the completion of multi-annual programmes bringing important answers, notably on operational aspects of long duration discharges. Concerning JET, particular effort have been devoted to: -) hydrogen isotopes retention studies, -) advanced scenarios studies such as JT60-JET physics identity experiments in ITB regimes, -) the commissioning of the ITER-like ICRH antenna, and -) high power level commissioning of the LHCD antenna and long distance coupling studies. Concerning integrated modelling, the development of the CRONOS code suite has been carried on, with particular emphasis on increasing its reliability and international coverage. CRONOS has been extensively used to investigate steady-state scenarios for ITER and DEMO. Most of the technological developments carried out by the Association concentrates on key domains that apply to ITER: superconducting conductors, actively cooled PFC (plasma facing components), or diagnostics. This document is an executive summary

Executive summary: Prevention and treatment of opportunistic infections and other coinfections in HIV-infected patients: May 2015.

Science.gov (United States)

Iribarren, José Antonio; Rubio, Rafael; Aguirrebengoa, Koldo; Arribas, Jose Ramón; Baraia-Etxaburu, Josu; Gutiérrez, Félix; Lopez Bernaldo de Quirós, Juan Carlos; Losa, Juan Emilio; Miró, José Ma; Moreno, Santiago; Pérez Molina, José; Podzamczer, Daniel; Pulido, Federico; Riera, Melchor; Rivero, Antonio; Sanz Moreno, José; Amador, Concha; Antela, Antonio; Arazo, Piedad; Arrizabalaga, Julio; Bachiller, Pablo; Barros, Carlos; Berenguer, Juan; Caylá, Joan; Domingo, Pere; Estrada, Vicente; Knobel, Hernando; Locutura, Jaime; López Aldeguer, José; Llibre, Josep Ma; Lozano, Fernando; Mallolas, Josep; Malmierca, Eduardo; Miralles, Celia; Miralles, Pilar; Muñoz, Agustín; Ocampo, Agustín; Olalla, Julián; Pérez, Inés; Pérez Elías, Ma Jesús; Pérez Arellano, José Luis; Portilla, Joaquín; Ribera, Esteban; Rodríguez, Francisco; Santín, Miguel; Sanz Sanz, Jesús; Téllez, Ma Jesús; Torralba, Miguel; Valencia, Eulalia; Von Wichmann, Miguel Angel

2016-10-01

Opportunistic infections continue to be a cause of morbidity and mortality in HIV-infected patients. They often arise because of severe immunosuppression resulting from poor adherence to antiretroviral therapy, failure of antiretroviral therapy, or unawareness of HIV infection by patients whose first clinical manifestation of AIDS is an opportunistic infection. The present article is an executive summary of the document that updates the previous recommendations on the prevention and treatment of opportunistic infections in HIV-infected patients, namely, infections by parasites, fungi, viruses, mycobacteria, and bacteria, as well as imported infections. The article also addresses immune reconstitution inflammatory syndrome. This document is intended for all professionals who work in clinical practice in the field of HIV infection. Copyright © 2016 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

Media Campaigns and Crime Prevention: An Executive Summary.

Science.gov (United States)

Mendelsohn, Harold; O'Keefe, Garrett J.

This summary report highlights the results of a study that examined the effects of the first phase of a nationwide, multimedia, crime prevention campaign featuring a trench-coated, animated dog named McGruff. Following an introduction explaining the purpose of the two surveys that comprised the study, the eight remaining sections of the report…

Final Generic Environmental Impact Statement. Handling and storage of spent light water power reactor fuel. Volume 1. Executive summary and text

International Nuclear Information System (INIS)

1979-08-01

The Generic Environmental Impact Statement on spent fuel storage was prepared by the Nuclear Regulatory Commission staff in response to a directive from the Commissioners published in the Federal Register, September 16, 1975 (40 FR 42801). The Commission directed the staff to analyze alternatives for the handling and storage of spent light water power reactor fuel with particular emphasis on developing long range policy. Accordingly, the scope of this statement examines alternative methods of spent fuel storage as well as the possible restriction or termination of the generation of spent fuel through nuclear power plant shutdown. Volume 1 includes the executive summary and the text

Prospective associations between bilingualism and executive function in Latino children: sustained effects while controlling for biculturalism.

Science.gov (United States)

Riggs, Nathaniel R; Shin, Hee-Sung; Unger, Jennifer B; Spruijt-Metz, Donna; Pentz, Mary Ann

2014-10-01

The study purpose was to test 1-year prospective associations between English-Spanish bilingualism and executive function in 5th to 6th grade students while controlling for biculturalism. Participants included 182 US Latino students (50 % female). Self-report surveys assessed biculturalism, bilingualism, and executive function (i.e., working memory, organizational skills, inhibitory control, and emotional control, as well as a summary executive function score). General linear model regressions demonstrated that bilingualism significantly predicted the summary executive function score as well as working memory such that bilingual proficiency was positively related to executive function. Results are the first to demonstrate (a) prospective associations between bilingualism to executive function while controlling for the potential third variable of biculturalism, and (b) a principal role for working memory in this relationship. Since executive function is associated with a host of health outcomes, one implication of study findings is that bilingualism may have an indirect protective influence on youth development.

Environmental Impact Statement: Waste Isolation Pilot Plant (WIPP): Executive summary

International Nuclear Information System (INIS)

1980-10-01

The purpose of this document is to provide a summary of the environmental impact statement for the Waste Isolation Pilot Plant (WIPP) project. The Draft Environmental Impact Statement for the WIPP was published by the US Department of Energy (DOE) in April 1979. This document was reviewed and commented on by members of the general public, private organizations, and governmental agencies. The Final Environmental Impact Statement was subsequently published in October, 1980. This summary is designed to assist decision-maker and interested individuals in reviewing the material presented in the environmental impact statement for the WIPP project. To make this material widely available, this summary is published in both Spanish and English. Additional, more detailed information concerning the environmental and safety consequences of the WIPP project is available in the Final Environmental Impact Statement. Written comments and public hearing comments on the Draft Environmental Impact Statement are available for review. 27 refs., 4 figs., 7 tabs

Indexing for summary queries

DEFF Research Database (Denmark)

Yi, Ke; Wang, Lu; Wei, Zhewei

2014-01-01

), of a particular attribute of these records. Aggregation queries are especially useful in business intelligence and data analysis applications where users are interested not in the actual records, but some statistics of them. They can also be executed much more efficiently than reporting queries, by embedding...... returned by reporting queries. In this article, we design indexing techniques that allow for extracting a statistical summary of all the records in the query. The summaries we support include frequent items, quantiles, and various sketches, all of which are of central importance in massive data analysis....... Our indexes require linear space and extract a summary with the optimal or near-optimal query cost. We illustrate the efficiency and usefulness of our designs through extensive experiments and a system demonstration....

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary.

Science.gov (United States)

Vogelmeier, Claus F; Criner, Gerard J; Martinez, Fernando J; Anzueto, Antonio; Barnes, Peter J; Bourbeau, Jean; Celli, Bartolome R; Chen, Rongchang; Decramer, Marc; Fabbri, Leonardo M; Frith, Peter; Halpin, David M G; López Varela, M Victorina; Nishimura, Masaharu; Roche, Nicolas; Rodriguez-Roisin, Roberto; Sin, Don D; Singh, Dave; Stockley, Robert; Vestbo, Jørgen; Wedzicha, Jadwiga A; Agusti, Alvar

2017-03-01

This Executive Summary of the Global Strategy for the Diagnosis, Management, and Prevention of COPD (GOLD) 2017 Report focuses primarily on the revised and novel parts of the document. The most significant changes include: 1) the assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation. ABCD groups are now proposed to be derived exclusively from patient symptoms and their history of exacerbations; 2) for each of the groups A to D, escalation strategies for pharmacological treatments are proposed; 3) the concept of de-escalation of therapy is introduced in the treatment assessment scheme; 4) nonpharmacologic therapies are comprehensively presented and; 5) the importance of comorbid conditions in managing COPD is reviewed. Copyright ©2017 the American Thoracic Society. Published with permission from the American Thoracic Society. Design and branding are copyright ©ERS 2017.

Forschende und ihre Daten: Ergebnisse einer österreichweiten Befragung. Report 2015 – Executive Summary und Empfehlungen

Directory of Open Access Journals (Sweden)

Bruno Bauer

2015-01-01

Full Text Available Der vorliegende Beitrag bringt Executive Summary und Empfehlungen aus „Forschende und ihre Daten: Ergebnisse einer österreichweiten Befragung. Report 2015“. Dieser Report gibt einen Überblick über die österreichweite Befragung zu Forschungsdaten, die im Rahmen des Projekts e-Infrastructures Austria 2015 durchgeführt wurde. Diese richtete sich an das wissenschaftliche und künstlerisch-wissenschaftliche Personal aller 21 öffentlichen Universitäten sowie an drei außeruniversitäre Forschungseinrichtungen in Österreich. Die Teilnehmenden wurden zu folgenden Themenbereichen befragt: Datentypen und Formate; Datenarchivierung, -sicherung und -verlust; ethische und rechtliche Aspekte; Zugänglichkeit und Nachnutzung; Infrastruktur und Services. Die in diesem Kontext erstmals auf nationaler Ebene durchgeführte Befragung diente der Erhebung des praktischen Umgangs mit Forschungsdaten in Österreich und ist somit die Basis für eine konsekutive Optimierung der zweckdienlichen Infrastruktur, für eine Anpassung der Serviceangebote sowie für eine Neuorientierung bei der Ermittlung von Ressourcen in diesem strategischen Bereich entsprechend der geäußerten Bedürfnisse der im Forschungsprozess Tätigen.

Bleeding risk assessment and management in atrial fibrillation patients. Executive Summary of a Position Document from the European Heart Rhythm Association [EHRA], endorsed by the European Society of Cardiology [ESC] Working Group on Thrombosis

NARCIS (Netherlands)

Lip, Gregory Y. H.; Andreotti, Felicita; Fauchier, Laurent; Huber, Kurt; Hylek, Elaine; Knight, Eve; Lane, Deirdre; Levi, Marcel; Marín, Francisco; Palareti, Gualtiero; Kirchhof, Paulus

2011-01-01

In this executive summary of a Consensus Document from the European Heart Rhythm Association, endorsed by the European Society of Cardiology Working Group on Thrombosis, we comprehensively review the published evidence and propose a consensus on bleeding risk assessments in atrial fibrillation (AF)

Impact of non-menthol flavours in tobacco products on perceptions and use among youth, young adults and adults: a systematic review.

Science.gov (United States)

Huang, Li-Ling; Baker, Hannah M; Meernik, Clare; Ranney, Leah M; Richardson, Amanda; Goldstein, Adam O

2017-11-01

This systematic review examines the impact of non-menthol flavours in tobacco products on tobacco use perceptions and behaviours among youth, young adults and adults. English-language peer-reviewed publications indexed in 4 databases were searched through April 2016. A search strategy was developed related to tobacco products and flavours. Of 1688 articles identified, we excluded articles that were not English-language, were not peer-reviewed, were qualitative, assessed menthol-flavoured tobacco products only and did not contain original data on outcomes that assessed the impact of flavours in tobacco products on perceptions and use behaviour. Outcome measures were identified and tabulated. 2 researchers extracted the data independently and used a validated quality assessment tool to assess study quality. 40 studies met the inclusion criteria. Data showed that tobacco product packaging with flavour descriptors tended to be rated as more appealing and as less harmful by tobacco users and non-users. Many tobacco product users, especially adolescents, reported experimenting, initiating and continuing to use flavoured products because of the taste and variety of the flavours. Users of many flavoured tobacco products also showed decreased likelihood of intentions to quit compared with non-flavoured tobacco product users. Flavours in most tobacco products appear to play a key role in how users and non-users, especially youth, perceive, initiate, progress and continue using tobacco products. Banning non-menthol flavours from tobacco products may ultimately protect public health by reducing tobacco use, particularly among youth. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

The influence of menthol, e-cigarettes and other tobacco products on young adults' self-reported changes in past year smoking.

Science.gov (United States)

Delnevo, Cristine D; Villanti, Andrea C; Wackowski, Olivia A; Gundersen, Daniel A; Giovenco, Daniel P

2016-09-01

Progression to regular smoking often occurs during young adulthood. This study examines self-reported changes in past year smoking among young adults and the potential influence of tobacco products on these trajectories. Respondents to the 2011 National Young Adult Health Survey who smoked 100 cigarettes in their lifetime (n=909) described smoking behaviour at the time of the survey and 1 year prior. Cigarette smoking trajectories were categorised as: no change, quit, decreased smoking or increased smoking. Participants were also asked about current use of menthol cigarettes and other tobacco products (ie, cigars, smokeless tobacco, hookah) and ever use of e-cigarettes. Most young adults (73.1%) reported stable cigarette smoking behaviours, while 8.2% reported having quit, 5.8% reported that they smoke on fewer days, 5% progressed from someday to daily smoking and 8% increased from not at all to current smoking. The youngest smokers (18-20) had significantly higher odds (adjusted OR (AOR) =2.6) of increasing cigarette use over the past year compared to those aged 30-34, as did blacks versus whites (AOR=2.35). Menthol cigarette use nearly doubled (AOR=1.87) the odds of increased smoking behaviour. E-cigarette and other tobacco product (OTP) use were not associated with increasing smoking but OTP use was negatively associated with remaining quit from cigarettes. Young adulthood is a critical period for smoking interventions, particularly among those most vulnerable to increasing smoking behaviours (ie, black and younger young adults). Policy efforts to restrict menthol cigarettes may reduce young adult smoking progression. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Determination of free and glucosidically-bound volatiles in plants. Two case studies: L-menthol in peppermint (Mentha x piperita L.) and eugenol in clove (Syzygium aromaticum (L.) Merr. & L.M.Perry).

Science.gov (United States)

Sgorbini, Barbara; Cagliero, Cecilia; Pagani, Alberto; Sganzerla, Marla; Boggia, Lorenzo; Bicchi, Carlo; Rubiolo, Patrizia

2015-09-01

This study arises from both the today's trend towards exploiting plant resources exhaustively, and the wide quantitative discrepancy between the amounts of commercially-valuable markers in aromatic plants and those recovered from the related essential oil. The study addresses the determination of both the qualitative composition and the exhaustive distribution of free and glucosidically-bound L-menthol in peppermint aerial parts (Mentha x piperita L., Lamiaceae) and of eugenol in dried cloves (Syzygium aromaticum (L.) Merr. & L.M.Perry, Myrtaceae), two plants known to provide widely ranging essential oil yields. The two markers were investigated in essential oils and residual hydrodistillation waters, before and after enzymatic hydrolysis. Their amounts were related to those in the headspace taken as reference. The results showed that the difference between marker compound in headspace and in essential oil amounted to 22.8% for L-menthol in peppermint, and 16.5% for eugenol in cloves. The aglycones solubilised in the residual hydrodistillation waters were 7.2% of the headspace reference amount for L-menthol, and 13.3% for eugenol, respectively representing 9.3% and 15.9% of their amounts in the essential oil. The amount of L-menthol from its glucoside in residual hydrodistillation waters was 20.6% of that in the related essential oil, while eugenol from its glucoside accounted for 7.7% of the amount in clove essential oil. The yield of L-menthol, after submitting the plant material to enzymatic hydrolysis before hydrodistillation, increased by 23.1%, and for eugenol the increase was 8.1%, compared to the amount in the respective conventional essential oils. This study also aimed to evaluate the reliability of recently-introduced techniques that are little applied, if at all, in this field. The simultaneous use of high-concentration-capacity sample preparation techniques (SBSE, and HS-SPME and in-solution SPME) to run quali-quantitative analysis without sample

Executive summary

International Nuclear Information System (INIS)

2010-01-01

The special session on Fuel cycle strategies and transition scenarios comprised three invited papers and five oral presentations: INL (USA) was invited to present US activities on fuel cycle transition scenarios; JAEA (Japan) presented the current status of the Japanese nuclear fuel cycle; CEA and EDF (France) gave a presentation on the French fuel cycle strategy and transition scenarios; CEA and INL presented the latest outcomes from the NEA activity on fuel cycle transition scenarios and the European approach; JAEA reported on the results of global scenarios for fast reactor deployment; AECL (Canada) discussed actinide transmutation in Candu reactors, which may efficiently transmute TRU; Materials assessments, which could be used in advanced nuclear fuel cycles from a safeguard perspective, were presented by LANL (USA); The technical session about Impact on P and T on waste management and geological disposal comprised one invited paper and two oral presentations: JAEA presented on the concept of waste management and geological disposal incorporating P and T technology; CIEMAT (Spain) gave a summary of the RED-IMPACT study, which is the study of the impact of P and T on the HLW management programme of the EC; Chalmers University(Sweden) presented an estimation of maximum permissible step losses in P and T processing; The technical session about Progress in transmutation fuels and targets comprised one invited paper and seven oral presentations: The invited talk of the session was given by ITU (EC), on advanced fuel fabrication processes for transmutation; INL presented the development status of transuranic-bearing metal fuels in the USA; CEA summarised European projects on design, development and qualification of advanced fuels for an industrial ADS prototype; The Japanese study of the microstructural evolution and Am migration behaviour in Am-containing MOX fuels at the initial stage of irradiation was presented by JAEA discussed Japanese status on the

Development of Design Technology on Thermal-Hydraulic Performance in Tight-Lattice Rod Bundles: I-Master Plan and Executive Summary

Science.gov (United States)

Ohnuki, Akira; Kureta, Masatoshi; Yoshida, Hiroyuki; Tamai, Hidesada; Liu, Wei; Misawa, Takeharu; Takase, Kazuyuki; Akimoto, Hajime

R&D project to investigate thermal-hydraulic performance in tight-lattice rod bundles for Innovative Water Reactor for Flexible Fuel Cycle has been progressed at Japan Atomic Energy Agency in collaboration with power utilities, reactor vendors and universities since 2002. In this series-study, we will summarize the R&D achievements using large-scale test facility (37-rod bundle with full-height and full-pressure), model experiments and advanced numerical simulation technology. This first paper described the master plan for the development of design technology and showed an executive summary for this project up to FY2005. The thermal-hydraulic characteristics in the tight-lattice configuration were investigated and the feasibility was confirmed based on the experiments. We have developed the design technology including 3-D numerical simulation one to evaluate the effects of geometry/scale on the thermal-hydraulic behaviors.

Regulation, characterization and treatment of discharge waters from pipelines. Volume 1. Topical report, January 1989-April 1992. Executive summary

International Nuclear Information System (INIS)

Tallon, J.T.; Fillo, J.P.

1992-04-01

The report examines environmental issues related to hydrostatic testing of discharge waters generated from integrity testing of natural gas pipelines. Hydrostatic testing, and proper environmental management of the discharge waters, can be required by DOT regulations. However, disposal of water used to conduct a hydrostatic pipeline test is regulated on a state-by-state basis. State-specific requirements vary widely, ranging from an authorization letter to a complete NPDES permit. Monitoring may be required before and during discharge, include a variety of analyses, have varying protocols for obtaining samples, and may be required either to obtain data or to ascertain compliance with stipulated discharge limits. The composition of the discharge and state-specific discharge limitations dictate treatment needs on a case-by-case basis. The volume consists of the Executive Summary of a five-volume report series

Joint Peru/United States report on Peru/United States cooperative energy assessment. Volume 1. Executive summary, main report and appendices

Energy Technology Data Exchange (ETDEWEB)

1979-08-01

In 1978, the US and Peru conducted a comprehensive assessment of Peru's energy resources, needs, and uses and developed several alternative energy strategies that utilize the available resources to meet their energy requirements. This Volume I reports the findings of the assessment and contains the executive summary, the main report, and five appendices of information that support the integrated energy supply and demand analysis. The following chapters are included: The Energy Situation in Peru (economic context and background, energy resources and production, energy consumption patterns); Reference Supply and Demand Projection (approach, procedures, and assumptions; economic projections; energy demand and supply projections; supply/demand integration; uncertainties); and The Development of Strategies and Options (the analysis of options; strategies; increased use of renewables, hydropower, coal; increased energy efficiency; and financial analysis of strategies).

US enrichment safeguards program development activities with potential International Atomic Energy Agency safeguards applications. Part 1. Executive summaries

International Nuclear Information System (INIS)

Swindle, D.W. Jr.

1984-07-01

The most recent progress, results, and plans for future work on the US Enrichment Safeguards Program's principal development activities are summarized. Nineteen development activities are reported that have potential International Atomic Energy Agency (IAEA) safeguards applications. Part 1 presents Executive Summaries for these, each of which includes information on (1) the purpose and scope of the development activity; (2) the potential IAEA safeguards application and/or use if adopted; (3) significant development work, results, and/or conclusions to date; and where appropriate (4) future activities and plans for continued work. Development activities cover: measurement technology for limited-frequency-unannounced-access stategy inspections; integrated data acquisition system; enrichment-monitoring system; load-cell-based weighing system for UF 6 cylinder mass verifications; vapor phase versus liquid phase sampling of UF 6 cylinders; tamper-safing hardware and systems; an alternative approach to IAEA nuclear material balance verifications resulting from intermittent inspections; UF 6 sample bottle enrichment analyzer; crated waste assay monitor; and compact 252 Cf shuffler for UF 6 measurements

Executive Summary to EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals.

Science.gov (United States)

Gore, A C; Chappell, V A; Fenton, S E; Flaws, J A; Nadal, A; Prins, G S; Toppari, J; Zoeller, R T

2015-12-01

This Executive Summary to the Endocrine Society's second Scientific Statement on environmental endocrine-disrupting chemicals (EDCs) provides a synthesis of the key points of the complete statement. The full Scientific Statement represents a comprehensive review of the literature on seven topics for which there is strong mechanistic, experimental, animal, and epidemiological evidence for endocrine disruption, namely: obesity and diabetes, female reproduction, male reproduction, hormone-sensitive cancers in females, prostate cancer, thyroid, and neurodevelopment and neuroendocrine systems. EDCs such as bisphenol A, phthalates, pesticides, persistent organic pollutants such as polychlorinated biphenyls, polybrominated diethyl ethers, and dioxins were emphasized because these chemicals had the greatest depth and breadth of available information. The Statement also included thorough coverage of studies of developmental exposures to EDCs, especially in the fetus and infant, because these are critical life stages during which perturbations of hormones can increase the probability of a disease or dysfunction later in life. A conclusion of the Statement is that publications over the past 5 years have led to a much fuller understanding of the endocrine principles by which EDCs act, including nonmonotonic dose-responses, low-dose effects, and developmental vulnerability. These findings will prove useful to researchers, physicians, and other healthcare providers in translating the science of endocrine disruption to improved public health.

Assessment of the in vivo genotoxicity of cadmium chloride, chloroform, and D,L-menthol as coded test chemicals using the alkaline comet assay.

Science.gov (United States)

Wada, Kunio; Fukuyama, Tomoki; Nakashima, Nobuaki; Matsumoto, Kyomu

2015-07-01

As part of the Japanese Center for the Validation of Alternative Methods (JaCVAM) international validation study of in vivo rat alkaline comet assays, we examined cadmium chloride, chloroform, and D,L-menthol under blind conditions as coded chemicals in the liver and stomach of Sprague-Dawley rats after 3 days of administration. Cadmium chloride showed equivocal responses in the liver and stomach, supporting previous reports of its poor mutagenic potential and non-carcinogenic effects in these organs. Treatment with chloroform, which is a non-genotoxic carcinogen, did not induce DNA damage in the liver or stomach. Some histopathological changes, such as necrosis and degeneration, were observed in the liver; however, they did not affect the comet assay results. D,L-Menthol, a non-genotoxic non-carcinogen, did not induce liver or stomach DNA damage. These results indicate that the comet assay can reflect genotoxic properties under blind conditions. Copyright © 2015 Elsevier B.V. All rights reserved.

Chiral pyrrolidinium salts derived from menthol as precursor – synthesis and properties

Directory of Open Access Journals (Sweden)

Janus Ewa

2017-09-01

Full Text Available Six new chiral pyrolidinium salts with chiral substituent at quaternary nitrogen atom were synthesized with high overall yields from (--menthol as cheap chiral precursor and were identified by NMR and HRMS spectroscopy. It was shown that anion type had the effect on chemical shift of protons adjacent to quaternary nitrogen atom and physical properties of these salts. Salts with NTf2 or NPf2 were in a liquid state at room temperature and characterized with the highest thermal stability among others. Furthermore, chiral ionic liquid with NTf2 anion was used as solvent in Diels-Alder reaction and gave higher yield and stereoselectivity than in ionic liquids with achiral cations. Synthesized chiral salts have the potential as chiral solvents in synthesis and auxiliaries in analytical methods to improve chiral recognition.

75 FR 69063 - Senior Executive Service; Performance Review Board

Science.gov (United States)

2010-11-10

... DEPARTMENT OF ENERGY Senior Executive Service; Performance Review Board AGENCY: U.S. Department of Energy. ACTION: Designation of Performance Review Board Chair. SUMMARY: This notice provides the Performance Review Board Chair designee for the Department of Energy. DATES: This appointment is effective as...

78 FR 70029 - Senior Executive Service; Performance Review Board

Science.gov (United States)

2013-11-22

... DEPARTMENT OF ENERGY Senior Executive Service; Performance Review Board AGENCY: U.S. Department of Energy ACTION: Designation of Performance Review Board Co-Chairs. SUMMARY: This notice provides the Performance Review Board Co-Chairs designees for the Department of Energy. DATES: This appointment is...

77 FR 64969 - Senior Executive Service; Performance Review Board

Science.gov (United States)

2012-10-24

... DEPARTMENT OF ENERGY Senior Executive Service; Performance Review Board AGENCY: U.S. Department of Energy. ACTION: Designation of Performance Review Board Chair. SUMMARY: This notice provides the Performance Review Board Chair designee for the Department of Energy. DATES: This appointment is effective as...

76 FR 70713 - Senior Executive Service; Performance Review Board

Science.gov (United States)

2011-11-15

... DEPARTMENT OF ENERGY Senior Executive Service; Performance Review Board AGENCY: U.S. Department of Energy. ACTION: Designation of Performance Review Board Chair. SUMMARY: This notice provides the Performance Review Board Chair designee for the Department of Energy. DATES: This appointment is effective as...

Sexual Harassment DEOCS 4.1 Construct Validity Summary

Science.gov (United States)

2017-08-01

Sexual Harassment DEOCS 4.1 Construct Validity Summary DEFENSE EQUAL OPPORTUNITY MANAGEMENT INSTITUTE...DIRECTORATE OF RESEARCH DEVELOPMENT AND STRATEGIC INITIATIVES Directed by Dr. Daniel P. McDonald, Executive Director 366 Tuskegee Airmen Drive Patrick AFB

Summaries of FY 1989 research in the chemical sciences

International Nuclear Information System (INIS)

1989-08-01

These summaries provide the scientific and technical public, as well as the legislative and executive branches of the Government, information, either generally or in some depth, about the Chemical Sciences program. Areas of research supported are indicated in the section headings, the ''Selected Topics of General Interest'' list, and the summaries themselves. Energy technologies that may be advanced by use of the basic knowledge generated in this program are included in the ''Selected Topics of General Interest'' list and are often referenced in the summaries

Lower Flathead System Fisheries Study, Executive Summary, Volume I, 1983-1987 Final Report.

Energy Technology Data Exchange (ETDEWEB)

Cross, David; DosSantos, Joseph M.

1988-06-01

This Executive Summary, Volume I, of the lower Flathead System Fisheries Study Final Report, was prepared to provide a study overview for persons who are not fisheries scientists. The contents provide an introduction to the study and its objectives, a short description of the study area, a discussion of the major findings and conclusions of the study, and the description of fisheries management alternatives available to managers of the lower Flathead system. Technical reports were prepared for those portions of the study dealing with the lower Flathead River and its tributaries, Volume II, and the South Bay of Flathead Lake, Volume III. The annual hydrographic regime of the Flathead system, consisting of upper rivers, lake and lower river, has been modified by the construction and operation of two major hydroelectric facilities, Hungry Horse Dam on the south fork Flathead River and Kerr Dam at the outlet of Flathead Lake. The modified hydrographic regime has resulted in significant impacts to kokanee (Oncorhynchus nerka) and several species of trout. Kerr Dam, closed in 1938, controls Flathead Lake levels between 878.7 m (2883 ft) and 881.8 m (2893 ft) and discharges into the lower Flathead River. Kerr Dam is a 63.4 m (208 ft) high concrete arch structure located 7.2 km (4.5 miles) downstream from the outlet of Flathead Lake. The facility is used by Montana Power Company primarily for system frequency load control with some use for low level base load. 77 refs., 5 figs.

Executive Summary - Overview

International Nuclear Information System (INIS)

2005-01-01

Professor Andrzej Budzanowski was Director of IFJ in the years 1990-2004. On September 1st 2004, on IFJ joining the Polish Academy of Sciences, Professor Marek Jezabek has been nominated by the President of PAN as the Director of IFJ, for a 4-year term. Our Institute, with a personnel of 450 (182 research staff) and over 50 Ph.D. students, is presently one of the largest institutes of the Polish Academy of Sciences and one of the largest research institutes in Poland. The scientific staff consists on 120 post-doctoral researchers, 26 Associated Professors and 36 State-Nominated Professors. The total budget of the Institute for the year 2004 was about 56 million Euro. The IFJ is financed mainly from the state budget of the Ministry of Scientific Research and Information Technology. In 2004 this financing was about 4 million Euro, constituting 72% of the Institute's total budget. The remaining part of our 2004 budget came from individual research projects, also sponsored by the Ministry of Scientific Research (688 kEuro), from international projects (368 kEuro) and from the Institute's entrepreneurship activities (498 kEuro). Between 2003 and 2004 we doubled our income from international projects. For further budget information. The Scientific Council of the Institute, which consists of 40 elected members of the Institute's staff and 4 external members (elected representatives from other Polish institutes and universities), is authorized to confer Ph.D. degrees in Physics and related disciplines, and to initiate and conduct habilitation and professorship procedures. In 2003-2004 17 Ph.D. theses and 11 habilitations have been completed. Following their review procedures, 3 Associate Professors at the IFJ became state-nominated Professors, receiving their nominations from Poland's President, Mr. A. Kwasniewski. The Institute is structured into 17 scientific departments which cover the range of our scientific interests. A summary of our main scientific achievements in

Final summary report of the Nordic Nuclear Safety Research Program 1994 - 1997

International Nuclear Information System (INIS)

Bennerstedt, T.; Lemmens, A.

1999-11-01

This is a summary report of the NKS research program carried out 1994 - 1997. It is basically a compilation of the executive summaries of the final reports on the nine scientific projects carried out during that period. It highlights the conclusions, recommendations and other results of the projects. (au)

78 FR 63275 - Senior Executive Service Performance Review Boards Membership

Science.gov (United States)

2013-10-23

... DEPARTMENT OF TRANSPORTATION Office of the Secretary [Docket No. DOT-OST-2013-0184] Senior Executive Service Performance Review Boards Membership AGENCY: Office of the Secretary, Department of Transportation (DOT). ACTION: Notice of Performance Review Board (PRB) appointments. SUMMARY: DOT publishes the...

77 FR 43900 - Senior Executive Service Performance Review Boards Membership

Science.gov (United States)

2012-07-26

... DEPARTMENT OF TRANSPORTATION Office of the Secretary [Docket No. DOT-OST-2012-0111] Senior Executive Service Performance Review Boards Membership AGENCY: Office of the Secretary, Department of Transportation (DOT). ACTION: Notice of Performance Review Board (PRB) appointments. SUMMARY: DOT publishes the...

76 FR 55677 - Senior Executive Service (SES) Performance Review Board

Science.gov (United States)

2011-09-08

... GENERAL SERVICES ADMINISTRATION [Notice-CPO-2011-01; Docket 2011-0006; Sequence 15] Senior Executive Service (SES) Performance Review Board AGENCY: General Services Administration. ACTION: Notice. SUMMARY: Notice is hereby given of the appointment of new members to the General Services Administration...

76 FR 63986 - Senior Executive Service Performance Review Boards Membership

Science.gov (United States)

2011-10-14

... DEPARTMENT OF TRANSPORTATION Office of the Secretary [Docket No. DOT-OST-2011-0188] Senior Executive Service Performance Review Boards Membership AGENCY: Office of the Secretary, Department of Transportation (DOT). ACTION: Notice of Performance Review Board (PRB) appointments. SUMMARY: DOT publishes the...

Performance evaluation of the technical capabilities of DOE sites for disposal of mixed low-level waste. Volume 1: Executive summary

International Nuclear Information System (INIS)

1996-03-01

A team of analysts designed and conducted a performance evaluation (PE) to estimate the technical capabilities of fifteen Department of Energy sites for disposal of mixed low-level waste (i.e., waste that contains both low-level radioactive materials and hazardous constituents). Volume 1 summarizes the process for selecting the fifteen sites, the methodology used in the evaluation, and the conclusions derived from the evaluation. Volume 1 is an executive summary both of the PE methodology and of the results obtained from the PEs. While this volume briefly reviews the scope and method of analyses, its main objective is to emphasize the important insights and conclusions derived from the conduct of the PEs. Volume 2 provides details about the site-selection process, the performance-evaluation methodology, and the overall results of the analysis. Volume 3 contains detailed evaluations of the fifteen sites and discussions of the results for each site

75 FR 68668 - Senior Executive Service; Departmental Performance Review Board

Science.gov (United States)

2010-11-08

... DEPARTMENT OF THE TREASURY Senior Executive Service; Departmental Performance Review Board AGENCY: Treasury Department. ACTION: Notice of members of the Departmental Offices Performances Review Board. SUMMARY: Pursuant to 5 U.S.C. 4314(c)(4), this notice announces the appointment of members of the...

Planning the Future of U.S. Particle Physics (Snowmass 2013): Chapter 1: Summary

Energy Technology Data Exchange (ETDEWEB)

Rosner, J.L.; et al.

2014-01-23

These reports present the results of the 2013 Community Summer Study of the APS Division of Particles and Fields ("Snowmass 2013") on the future program of particle physics in the U.S. Chapter 1 contains the Executive Summary and the summaries of the reports of the nine working groups.

Executive functions predict weight loss in a medically supervised weight loss programme

OpenAIRE

Galioto, R.; Bond, D.; Gunstad, J.; Pera, V.; Rathier, L.; Tremont, G.

2016-01-01

Summary Background Deficits in executive functions are related to poorer weight loss after bariatric surgery; however, less is known about the role that these deficits may play during participation in nonsurgical weight loss programmes. This study examined associations between objectively measured executive functions and weight loss during participation in a medically supervised weight loss programme. Methods Twenty?three adult patients (age 50.4???15.1, BMI 44.2???8.8, 68% female, 92% White)...

Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation.

Science.gov (United States)

Borowiec, Anne-Sophie; Sion, Benoit; Chalmel, Frédéric; D Rolland, Antoine; Lemonnier, Loïc; De Clerck, Tatiana; Bokhobza, Alexandre; Derouiche, Sandra; Dewailly, Etienne; Slomianny, Christian; Mauduit, Claire; Benahmed, Mohamed; Roudbaraki, Morad; Jégou, Bernard; Prevarskaya, Natalia; Bidaux, Gabriel

2016-09-01

Testes of most male mammals present the particularity of being externalized from the body and are consequently slightly cooler than core body temperature (4-8°C below). Although, hypothermia of the testis is known to increase germ cells apoptosis, little is known about the underlying molecular mechanisms, including cold sensors, transduction pathways, and apoptosis triggers. In this study, using a functional knockout mouse model of the cold and menthol receptors, dubbed transient receptor potential melastatine 8 (TRPM8) channels, we found that TRPM8 initiated the cold-shock response by differentially modulating cold- and heat-shock proteins. Besides, apoptosis of germ cells increased in proportion to the cooling level in control mice but was independent of temperature in knockout mice. We also observed that the rate of germ cell death correlated positively with the reactive oxygen species level and negatively with the expression of the detoxifying enzymes. This result suggests that the TRPM8 sensor is a key determinant of germ cell fate under hypothermic stimulation.-Borowiec, A.-S., Sion, B., Chalmel, F., Rolland, A. D., Lemonnier, L., De Clerck, T., Bokhobza, A., Derouiche, S., Dewailly, E., Slomianny, C., Mauduit, C., Benahmed, M., Roudbaraki, M., Jégou, B., Prevarskaya, N., Bidaux, G. Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation. © The Author(s).

77 FR 64521 - Updated OGE Senior Executive Service Performance Review Board

Science.gov (United States)

2012-10-22

... Ethics, Environmental Protection Agency; Melinda Loftin, Director of Interior Ethics Office, Department... OFFICE OF GOVERNMENT ETHICS Updated OGE Senior Executive Service Performance Review Board AGENCY: Office of Government Ethics (OGE). ACTION: Notice. SUMMARY: Notice is hereby given of the appointment of...

Warhead Monitoring Planning and Execution

Energy Technology Data Exchange (ETDEWEB)

Nakae, L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2017-12-05

The Warhead Measurement Campaign is a multi-laboratory project lead by the Los Alamos National Laboratory. The project will measure several items of the US nuclear weapons stockpile with a wide range of radiation detection systems. This report provides a brief summary of those LLNL executed activities for the Warhead Measurement Campaign from FY11 through FY16. A more detailed description of all of LLNL’s activiites for the WMC will be presented in the final report of a follow-on project, , LA17-V-Wx.

78 FR 52995 - Senior Executive Service: Performance Review Board Members

Science.gov (United States)

2013-08-27

... SMALL BUSINESS ADMINISTRATION Senior Executive Service: Performance Review Board Members AGENCY: U. S. Small Business Administration. ACTION: Notice of Members for the FY 2014 Performance Review Board. SUMMARY: Title 5 U.S.C. 4314(c)(4) requires each agency to publish notification of the appointment of...

78 FR 75447 - Senior Executive Service; Departmental Performance Review Board

Science.gov (United States)

2013-12-11

... DEPARTMENT OF THE TREASURY Senior Executive Service; Departmental Performance Review Board AGENCY: Treasury Department. ACTION: Notice of members of the Departmental Performance Review Board (PRB). SUMMARY: Pursuant to 5 U.S.C. 4314(c)(4), this notice announces the appointment of members of the Departmental PRB...

76 FR 64421 - Senior Executive Service: Performance Review Board Members

Science.gov (United States)

2011-10-18

... SMALL BUSINESS ADMINISTRATION Senior Executive Service: Performance Review Board Members AGENCY: U.S. Small Business Administration. ACTION: Notice of Members for the FY 2011 Performance Review Board. SUMMARY: Title 5 U.S.C. 4314(c)(4) requires each agency to publish notification of the appointment of...

77 FR 70204 - Senior Executive Service: Performance Review Board Members

Science.gov (United States)

2012-11-23

... SMALL BUSINESS ADMINISTRATION Senior Executive Service: Performance Review Board Members AGENCY: U.S. Small Business Administration. ACTION: Notice of Members for the FY 2012 Performance Review Board. SUMMARY: Title 5 U.S.C. 4314(c)(4) requires each agency to publish notification of the appointment of...

75 FR 71785 - Senior Executive Service: Performance Review Board Members

Science.gov (United States)

2010-11-24

... SMALL BUSINESS ADMINISTRATION Senior Executive Service: Performance Review Board Members AGENCY: U.S. Small Business Administration. ACTION: Notice of Members for the FY 2010 Performance Review Board. SUMMARY: Title 5 U.S.C. 4314(c)(4) requires each agency to publish notification of the appointment of...

76 FR 69798 - Senior Executive Service; Departmental Performance Review Board

Science.gov (United States)

2011-11-09

... DEPARTMENT OF THE TREASURY Senior Executive Service; Departmental Performance Review Board AGENCY: Treasury Department. ACTION: Notice of members of the Departmental Performance Review Board (PRB). SUMMARY: Pursuant to 5 U.S.C. 4314(c)(4), this notice announces the appointment of members of the Departmental PRB...

DECOVALEX III PROJECT. Mathematical Models of Coupled Thermal-Hydro-Mechanical Processes for Nuclear Waste Repositories. Executive Summary

Energy Technology Data Exchange (ETDEWEB)

Jing, L.; Stephansson, O. [Royal Inst. of Technology, Stockholm (Sweden). Engineering Geology; Tsang, C.F. [Lawrence Berkely National Laboratory, Berkeley, CA (United States). Earth Science Div.; Mayor, J.C. [ENRESA, Madrid (Spain); Kautzky, F. [Swedish Nuclear Power Inspectorate, Stockholm (Sweden)] (eds.)

2005-02-15

DECOVALEX is an international consortium of governmental agencies associated with the disposal of high-level nuclear waste in a number of countries. The consortium's mission is the DEvelopment of COupled models and their VALidation against EXperiments. Hence the acronym/name DECOVALEX. Currently, agencies from Canada, Finland, France, Germany, Japan, Spain, Switzerland, Sweden, United Kingdom, and the United States are in DECOVALEX. Emplacement of nuclear waste in a repository in geologic media causes a number of physical processes to be intensified in the surrounding rock mass due to the decay heat from the waste. The four main processes of concern are thermal, hydrological, mechanical and chemical. Interactions or coupling between these heat-driven processes must be taken into account in modeling the performance of the repository for such modeling to be meaningful and reliable. DECOVALEX III is organized around four tasks. The FEBEX (Full-scale Engineered Barriers EXperiment) in situ experiment being conducted at the Grimsel site in Switzerland is to be simulated and analyzed in Task 1. Task 2, centered around the Drift Scale Test (DST) at Yucca Mountain in Nevada, USA, has several sub-tasks (Task 2A, Task 2B, Task 2C and Task 2D) to investigate a number of the coupled processes in the DST. Task 3 studies three benchmark problems: a) the effects of thermal-hydrologic-mechanical (THM) coupling on the performance of the near-field of a nuclear waste repository (BMT1); b) the effect of upscaling THM processes on the results of performance assessment (BMT2); and c) the effect of glaciation on rock mass behavior (BMT3). Task 4 is on the direct application of THM coupled process modeling in the performance assessment of nuclear waste repositories in geologic media. This executive summary presents the motivation, structure, objectives, approaches, and the highlights of the main achievements and outstanding issues of the tasks studied in the DECOVALEX III project

DECOVALEX III PROJECT. Mathematical Models of Coupled Thermal-Hydro-Mechanical Processes for Nuclear Waste Repositories. Executive Summary

International Nuclear Information System (INIS)

Jing, L.; Stephansson, O.; Kautzky, F.

2005-02-01

DECOVALEX is an international consortium of governmental agencies associated with the disposal of high-level nuclear waste in a number of countries. The consortium's mission is the DEvelopment of COupled models and their VALidation against EXperiments. Hence the acronym/name DECOVALEX. Currently, agencies from Canada, Finland, France, Germany, Japan, Spain, Switzerland, Sweden, United Kingdom, and the United States are in DECOVALEX. Emplacement of nuclear waste in a repository in geologic media causes a number of physical processes to be intensified in the surrounding rock mass due to the decay heat from the waste. The four main processes of concern are thermal, hydrological, mechanical and chemical. Interactions or coupling between these heat-driven processes must be taken into account in modeling the performance of the repository for such modeling to be meaningful and reliable. DECOVALEX III is organized around four tasks. The FEBEX (Full-scale Engineered Barriers EXperiment) in situ experiment being conducted at the Grimsel site in Switzerland is to be simulated and analyzed in Task 1. Task 2, centered around the Drift Scale Test (DST) at Yucca Mountain in Nevada, USA, has several sub-tasks (Task 2A, Task 2B, Task 2C and Task 2D) to investigate a number of the coupled processes in the DST. Task 3 studies three benchmark problems: a) the effects of thermal-hydrologic-mechanical (THM) coupling on the performance of the near-field of a nuclear waste repository (BMT1); b) the effect of upscaling THM processes on the results of performance assessment (BMT2); and c) the effect of glaciation on rock mass behavior (BMT3). Task 4 is on the direct application of THM coupled process modeling in the performance assessment of nuclear waste repositories in geologic media. This executive summary presents the motivation, structure, objectives, approaches, and the highlights of the main achievements and outstanding issues of the tasks studied in the DECOVALEX III project. The

77 FR 66793 - Senior Executive Service: Membership of Performance Review Board

Science.gov (United States)

2012-11-07

... AGENCY FOR INTERNATIONAL DEVELOPMENT Senior Executive Service: Membership of Performance Review Board ACTION: Notice. SUMMARY: This notice lists approved candidates who will comprise a standing roster for service on the Agency's 2012 and 2013 SES Performance Review Boards. The Agency will use this...

Market surveillance panel monitoring report on the IMO-administered electricity markets : Executive summary

International Nuclear Information System (INIS)

2002-01-01

The electricity market in Ontario was opened on May 1, 2002. This document provides the executive summary for the first monitoring report prepared by the Market Surveillance Panel covering the period May to August 2002. In the introductory chapter of the main report, explanations are provided on why competition, when effective, benefits consumers, as well as touching on the conditions for the design of an effective competitive electricity market with special emphasis on the electricity market in Ontario and its operations. For the period under review, the report presents a description and analysis of the activities and operations of the Independent Electricity Market Operator (IMO)-administered markets (focus on energy markets). Rising costs for hydroelectric power and very high temperatures combined in July and August resulting in record levels of demand. It became apparent that the province relies on imports to satisfy demand. The figures reveal that reliability in July and August depended on imports 21 per cent of the time. A serious shortage of generating capacity exists in Ontario and steps to rectify the situation should be initiated to ensure reliability of electricity supply for next summer. Prospective entrants in the electricity market in Ontario may not be receiving clear, credible and consistent signals. Effective use of existing or potential transmission capacity may not always be made by the system. The lowering of consumption by consumers is difficult since consumers are not properly equipped, resulting in their lack of power to discipline price increases from suppliers. The future evolution of the market must be planned and measures implemented to enhance the effectiveness of competition. The incentives effects for some aspects of the market design do not completely satisfy the Panel

75 FR 68669 - Senior Executive Service; Departmental Performance Review Board

Science.gov (United States)

2010-11-08

... DEPARTMENT OF THE TREASURY Senior Executive Service; Departmental Performance Review Board AGENCY: Treasury Department. ACTION: Notice. SUMMARY: Pursuant to 5 U.S.C. 4314(c)(4), this notice announces the appointment of members of the Departmental PRB. The purpose of this PRB is to review and make recommendations...

Effluent Information System (EIS) / Onsite Discharge Information System (ODIS): 1986 executive summary

International Nuclear Information System (INIS)

Watanabe, T.

1987-09-01

Department of Energy (DOE) data base systems aid DOE-Headquarters and Field Offices in managing the radioactive air and liquid effluents from DOE facilities. Data on effluents released offsite are entered into effluent information system (EIS) and data on effluents discharged onsite and retained onsite are entered into Onsite Discharge Information System (ODIS). This document is a summary of information obtained from the CY 1986 effluent data received from all DOE and DOE contractor facilities and entered in the data bases. Data from previous years are also included. The summary consists of information for effluents released offsite, and information for effluents retained onsite

76 FR 69797 - Senior Executive Service Departmental Offices Performance Review Board.

Science.gov (United States)

2011-11-09

... DEPARTMENT OF THE TREASURY Senior Executive Service Departmental Offices Performance Review Board. AGENCY: Treasury Department. ACTION: Notice of members of the Departmental Offices Performances Review Board. SUMMARY: Pursuant to 5 U.S.C. 4314(c)(4), this notice announces the appointment of members of the...

High integrity software for nuclear power plants: Candidate guidelines, technical basis and research needs. Executive summary: Volume 1

International Nuclear Information System (INIS)

Seth, S.; Bail, W.; Cleaves, D.; Cohen, H.; Hybertson, D.; Schaefer, C.; Stark, G.; Ta, A.; Ulery, B.

1995-06-01

The work documented in this report was performed in support of the US Nuclear Regulatory Commission to examine the technical basis for candidate guidelines that could be considered in reviewing and evaluating high integrity computer software used in the safety systems of nuclear power plants. The framework for the work consisted of the following software development and assurance activities: requirements specification; design; coding; verification and validation, including static analysis and dynamic testing; safety analysis; operation and maintenance; configuration management; quality assurance; and planning and management. Each activity (framework element) was subdivided into technical areas (framework subelements). The report describes the development of approximately 200 candidate guidelines that span the entire range of software life-cycle activities; the assessment of the technical basis for those candidate guidelines; and the identification, categorization and prioritization of research needs for improving the technical basis. The report has two volumes: Volume 1, Executive Summary, includes an overview of the framework and of each framework element, the complete set of candidate guidelines, the results of the assessment of the technical basis for each candidate guideline, and a discussion of research needs that support the regulatory function; Volume 2 is the main report

WOCN Society Clinical Guideline: Management of the Adult Patient With a Fecal or Urinary Ostomy-An Executive Summary.

Science.gov (United States)

This article provides an executive summary of the recommendations from the Clinical Guideline: Management of the Adult Patient With a Fecal or Urinary Ostomy, published by the Wound, Ostomy and Continence Nurses Society (WOCN Society). It presents an overview of the process used to update and develop the guideline and lists specific recommendations from the guideline. We provide recommendations that include the following topics: stoma construction, preoperative education, stoma site marking, selection of an ostomy pouching system, postoperative education, postoperative management issues, follow-up care after discharge from the acute care setting, health-related quality of life, and stomal and peristomal complications. The intent of the guideline is to provide information that will assist healthcare providers to manage adult patients with ostomies, prevent or decrease complications, and improve patient outcomes. The full text of the published guideline, which includes available evidence supporting the recommendations and a complete reference list, is available in print and as a mobile application from the WOCN Society's online bookstore (http://www.wocn.org). Refer to Supplemental Digital Content 1 (available at: http://links.lww.com/JWOCN/A40) associated with this article for a complete reference list for the guideline.

Anti-Inflammatory Properties of Menthol and Menthone in Schistosoma mansoni Infection

Science.gov (United States)

Zaia, Mauricio G.; Cagnazzo, Túlio di Orlando; Feitosa, Karina A.; Soares, Edson G.; Faccioli, Lúcia H.; Allegretti, Silmara M.; Afonso, Ana; Anibal, Fernanda de Freitas

2016-01-01

Schistosomiasis is a parasitic disease caused by several species of trematode worms and it is believed that more than 261 million people are affected worldwide. New drug development has become essential because there is a risk of the parasite becoming resistant to Praziquantel, the only drug available for this infection. This study evaluated parasitological, immunological and histological parameters in mice infected with Schistosoma mansoni and treated with an herbal commercial medicine. This drug consists of menthol (30–55%) and menthone (14–32%). A 60 day treatment regimen with the herbal medicine decreased the number of S. mansoni eggs in the feces, liver, and intestine and reduced the number of hepatic granulomas. We observed a reduction of 84% in blood eosinophilia and a decrease in the IL-4 and IL-10 blood levels after treatment. Therefore, we propose that schistosomiasis treatment with this herbal medicine for 60 days has an immunomodulatory and anti-inflammatory action in this animal model for schistosomiasis thus contributing to the decrease in physio pathological effects caused by S. mansoni infection. PMID:27378927

Effluent information system (EIS)/onsite discharge information system (ODIS) 1985 executive summary

International Nuclear Information System (INIS)

Watanabe, T.

1986-09-01

The Effluent Information System (EIS) and Onsite Discharge Information System (ODIS) are Department of Energy (DOE) data base systems that aid DOE-Headquarters and Field Offices in managing the radioactive air and liquid effluents from DOE facilities. Data on effluents released offsite are entered into EIS and data on effluents discharged onsite and retained onsite are entered into ODIS. This document is a summary of information obtained from the CY 1985 effluent data received from all DOE and DOE contractor facilities and entered in the data bases. Data from previous years are also included. The summary consists of two parts. The first part summarizes information for effluents released offsite, and the second part summarizes information for effluents retained onsite. These summaries are taken from the routine annual reports sent to each DOE Operations Office. Special tabulations or specific data can be supplied upon request. Explanations of the significant changes are included in the EIS and ODIS graphic sections. Only those changes in activity greater than a factor of two and having a magnitude greater than 0.1 Ci are considered significant and are addressed in the explanation

Does executive dysfunction affect treatment outcome in late-life mood and anxiety disorders?

Science.gov (United States)

Mohlman, Jan

2005-06-01

Rates of treatment response among the elderly are typically lower than those found in younger samples. This article discusses specific biological and psychological aspects of aging that may impact the effectiveness of treatments for late-life mood and anxiety disorders. Although empirical evidence for the role of executive skills in treatment outcome is currently quite limited, the small number of existing studies suggest that some older adults with deficits in executive skills may respond poorly to popular treatments for depression and anxiety compared with those with intact executive functions. However, there are likely to be additional mediating factors. This article provides a definition and description of executive functions, including a summary of popular assessment tools. The literature on treatment outcome is reviewed, and future directions are discussed.

Executive summary of the Diagnostic Criteria for Temporomandibular Disorders for clinical and research applications.

Science.gov (United States)

Schiffman, Eric; Ohrbach, Richard

2016-06-01

In this executive summary, the authors describe a protocol for assessing patients with temporomandibular disorder (TMD). It is based on the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for clinical and research applications. The DC/TMD was developed using published Axis I physical diagnoses for the most common TMDs. Axis I diagnostic criteria were derived from pertinent clinical TMD signs and symptoms. Axis II consists of psychosocial and behavioral questionnaires already in the public domain. A panel of experts vetted and modified the Axis I and Axis II diagnostic protocols. Recommended changes were assessed for diagnostic accuracy by using the Validation Project's data set, which formed the basis for the development of the DC/TMD. Axis I diagnostic criteria for TMD pain-related disorders have acceptable validity and provide definitive diagnoses for pain involving the temporomandibular joint (TMJ) and masticatory muscles. Axis I diagnostic criteria for the most common TMJ intra-articular disorders are appropriate for screening purposes only. A definitive diagnosis for TMJ intra-articular disorders requires computed tomography or magnetic resonance imaging. Axis II questionnaires provide valid assessment of psychosocial and behavioral factors that can affect management of TMD. The DC/TMD provides a questionnaire for the pain history in conjunction with validated clinical examination criteria for diagnosing the most common TMDs. In addition, it provides Axis II questionnaires for assessing psychosocial and behavioral factors that may contribute to the onset and perpetuation of the patient's TMD. The DC/TMD is appropriate for use in clinical and research settings to allow for a comprehensive assessment of patients with TMD. Copyright © 2016 American Dental Association. Published by Elsevier Inc. All rights reserved.

Summaries of FY 1997 engineering research

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-09-01

This report documents the Basic Energy Sciences (BES) Engineering Research Program for fiscal year 1997, it provides a summary for each of the program projects in addition to a brief program overview. The report is intended to provide staff of Congressional committees, other executive departments, and other DOE offices with substantive program information so as to facilitate governmental overview and coordination of Federal research programs. Of equal importance, its availability facilitates communication of program information to interested research engineers and scientists. The individual project summaries follow the program overview. The summaries are ordered alphabetically by name of institution; the table of contents lists all the institutions at which projects were sponsored in fiscal year 1997. Each project entry begins with an institutional-departmental heading. The names of investigators are listed immediately below the title. The funding level for fiscal year 1997 appears to the right of address. The summary description of the project completes the entry. A separate index of Principal Investigators includes phone number, fax number and e-main address, where available.

Executive summary of the KDIGO Controversies Conference on Supportive Care in Chronic Kidney Disease: developing a roadmap to improving quality care.

Science.gov (United States)

Davison, Sara N; Levin, Adeera; Moss, Alvin H; Jha, Vivekanand; Brown, Edwina A; Brennan, Frank; Murtagh, Fliss E M; Naicker, Saraladevi; Germain, Michael J; O'Donoghue, Donal J; Morton, Rachael L; Obrador, Gregorio T

2015-09-01

Patients with advanced chronic kidney disease (CKD) have a high burden of physical and psychosocial symptoms, poor outcomes, and high costs of care. Current paradigms of care for this highly vulnerable population are variable, prognostic and assessment tools are limited, and quality of care, particularly regarding conservative and palliative care, is suboptimal. The KDIGO Controversies Conference on Supportive Care in CKD reviewed the current state of knowledge in order to define a roadmap to guide clinical and research activities focused on improving the outcomes of people living with advanced CKD, including those on dialysis. An international group of multidisciplinary experts in CKD, palliative care, methodology, economics, and education identified the key issues related to palliative care in this population. The conference led to a working plan to address outstanding issues in this arena, and this executive summary serves as an output to guide future work, including the development of globally applicable guidelines.

77 FR 65248 - Senior Executive Service; Public Debt Performance Review Board

Science.gov (United States)

2012-10-25

... Performance Review Board AGENCY: Bureau of the Public Debt, Treasury. ACTION: Notice. SUMMARY: This notice announces the appointment of the members of the Public Debt Performance Review Board (PRB) for the Bureau of the Public Debt (BPD). The PRB reviews the performance appraisals of career senior executives who are...

76 FR 63351 - Senior Executive Service; Financial Management Service Performance Review Board (PRB)

Science.gov (United States)

2011-10-12

... DEPARTMENT OF THE TREASURY Senior Executive Service; Financial Management Service Performance Review Board (PRB) AGENCY: Financial Management Service, Treasury. ACTION: Notice. SUMMARY: This notice announces the appointment of members to the Financial Management Service (FMS) Performance Review Board (PRB...

77 FR 60177 - Senior Executive Service; Financial Management Service Performance Review Board (PRB)

Science.gov (United States)

2012-10-02

... DEPARTMENT OF THE TREASURY Senior Executive Service; Financial Management Service Performance Review Board (PRB) AGENCY: Financial Management Service, Treasury. ACTION: Notice. SUMMARY: This notice announces the appointment of members to the Financial Management Service (FMS) Performance Review Board (PRB...

'Literacy Octopus' Dissemination Trial: Evaluation Report and Executive Summary

Science.gov (United States)

Lord, Pippa; Rabiasz, Adam; Styles, Ben

2017-01-01

The "'Literacy Octopus' Dissemination Trial" aimed to test the impact on pupil outcomes of disseminating research summaries and evidence-based resources to schools. The materials aimed to support teaching and learning of Key Stage 2 literacy and were created by leading organisations with experience of engaging schools in evidence use.…

Compendium of Executive Summaries from the Maglev System Concept Definition. Final Reports

National Research Council Canada - National Science Library

1993-01-01

...) studies awarded under the National Maglev Initiative. These summaries present the technical feasibility, performance, capital, operating and maintenance costs for a maglev system that would be available by the year 2000...

Wound, Ostomy, and Continence Nursing: Scope and Standards of Practice, 2nd Edition: An Executive Summary.

Science.gov (United States)

2018-04-25

Wound, ostomy, and continence (WOC) nursing was recognized as a nursing specialty by the American Nurses Association in February 2010, and the Society published the original scope and standards of WOC nursing practice in May 2010. The Wound, Ostomy, and Continence Nursing: Scope and Standards of Practice, 2nd Edition is the definitive resource promoting excellence in professional practice, quality care, and improved patient outcomes in WOC specialty practice. It can be used to articulate the value of WOC nurses to administrators, legislators, payers, patients, and others. The second edition also provides an overview of the scope of WOC nursing practice including a description of the specialty, the history and evolution of WOC nursing, characteristics of WOC nursing practice, and description of the trispecialty. The document describes various WOC nurse roles, populations served, practice settings, care coordination, and collaboration. Educational preparation, levels of practice within WOC specialty nursing, certification, mandate for continuous professional development, ethics, current trends, future considerations and challenges, and standards of WOC nursing practice and professional performance with competencies for each standard are provided. The purpose of this Executive Summary is to describe the process for developing the scope and standards document, provide an overview of the scope of WOC nursing practice, and list the standards of practice and professional performance along with the competencies for each level of WOC nurse provider. The original document is available from the WOCN Society's online book store (www.wocn.org).

Summaries of FY 1996 engineering research

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-06-01

This report documents the Basic Energy Sciences (BES) Engineering Research Program for fiscal year 1996; it provides a summary for each of the program projects in addition to a brief program overview. The report is intended to provide staff of Congressional committees, other executive departments, and other DOE offices with substantive program information so as to facilitate governmental overview and coordination of Federal research programs. Of equal importance, its availability facilitates communication of program information to interested research engineers and scientists. Each BES Division administers basic, mission oriented research programs in the area indicated by its title. The BES Engineering Research Program is one such program; it is administered by the Engineering and Geosciences Division of BES. In preparing this report the principal investigators were asked to submit summaries for their projects that were specifically applicable to fiscal year 1996. The summaries received have been edited if necessary, but the press for timely publication made it impractical to have the investigators review and approve the revised summaries prior to publication. For more information about a given project, it is suggested that the investigators be contacted directly.

Executive Summary: European Heart Rhythm Association Consensus Document on the Management of Supraventricular Arrhythmias: Endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulación Cardiaca y Electrofisiologia (SOLAECE).

Science.gov (United States)

Katritsis, Demosthenes G; Boriani, Giuseppe; Cosio, Francisco G; Jais, Pierre; Hindricks, Gerhard; Josephson, Mark E; Keegan, Roberto; Knight, Bradley P; Kuck, Karl-Heinz; Lane, Deirdre A; Lip, Gregory Yh; Malmborg, Helena; Oral, Hakan; Pappone, Carlo; Themistoclakis, Sakis; Wood, Kathryn A; Young-Hoon, Kim; Lundqvist, Carina Blomström

2016-01-01

This paper is an executive summary of the full European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, published in Europace . It summarises developments in the field and provides recommendations for patient management, with particular emphasis on new advances since the previous European Society of Cardiology guidelines. The EHRA consensus document is available to read in full at http://europace.oxfordjournals.org.

76 FR 53699 - Labor Surplus Area Classification Under Executive Orders 12073 and 10582

Science.gov (United States)

2011-08-29

... DEPARTMENT OF LABOR Employment and Training Administration Labor Surplus Area Classification Under Executive Orders 12073 and 10582 AGENCY: Employment and Training Administration, Labor. ACTION: Notice SUMMARY: The purpose of this notice is to announce the annual list of labor surplus areas for Fiscal Year...

78 FR 63248 - Labor Surplus Area Classification under Executive Orders 12073 and 10582

Science.gov (United States)

2013-10-23

... DEPARTMENT OF LABOR Employment and Training Administration Labor Surplus Area Classification under Executive Orders 12073 and 10582 AGENCY: Employment and Training Administration, Labor. ACTION: Notice. SUMMARY: The purpose of this notice is to announce the annual list of labor surplus areas for Fiscal Year...

75 FR 9955 - Labor Surplus Area Classification Under Executive Orders 12073 and 10582

Science.gov (United States)

2010-03-04

... DEPARTMENT OF LABOR Employment and Training Administration Labor Surplus Area Classification Under Executive Orders 12073 and 10582 AGENCY: Employment and Training Administration, Labor. ACTION: Notice. SUMMARY: The purpose of this notice is to update the 2010 Labor Surplus Areas annual list published in the...

Parent-rated emotional-behavioral and executive functioning in childhood epilepsy.

Science.gov (United States)

Kavanaugh, Brian C; Scarborough, Vanessa Ramos; Salorio, Cynthia F

2015-01-01

The present study examined clinical and demographic risk factors associated with parent-rated emotional-behavioral and executive functioning in children and adolescents with epilepsy. The medical records of 152 children and adolescents with epilepsy referred for neuropsychological evaluation were reviewed. Results indicated that the sample displayed significantly elevated symptoms across the emotional-behavioral and executive domains assessed. Executive functioning and behavioral symptoms had the highest rates of clinically elevated scores, with lowest rates of elevated scores in internalizing and externalizing emotional problems. Only 34% of those participants with clinically significant emotional-behavioral or executive functioning difficulties had a history of psychological or counseling services, highlighting the underserved mental health needs of this population. In regard to clinical factors, the majority of seizure-related variables were not associated with emotional-behavioral or executive functioning. However, the frequency of seizures (i.e., seizure status) was associated with behavioral regulation aspects of executive functioning, and the age at evaluation was associated with externalizing problems and behavioral symptoms. Family psychiatric history (with the exception of ADHD) was associated with all domains of executive and emotional-behavioral functioning. In summary, emotional-behavioral and executive functioning difficulties frequently co-occur with seizures in childhood epilepsy, with both seizure-related and demographic factors contributing to the presentation of such neurobehavioral comorbidities. The present findings provide treatment providers of childhood epilepsy with important information to assist in better identifying children and adolescents who may be at risk for neurobehavioral comorbidities and may benefit from intervention. Copyright © 2014 Elsevier Inc. All rights reserved.

Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells.

NARCIS (Netherlands)

Thebault, S.C.; Lemonnier, L.; Bidaux, G.; Flourakis, M.; Bavencoffe, A.; Gordienko, D.; Roudbaraki, M.; Delcourt, P.; Panchin, Y.; Shuba, Y.; Skryma, R.; Prevarskaya, N.

2005-01-01

Recent cloning of a cold/menthol-sensitive TRPM8 channel (transient receptor potential melastatine family member 8) from rodent sensory neurons has provided the molecular basis for the cold sensation. Surprisingly, the human orthologue of rodent TRPM8 also appears to be strongly expressed in the

75 FR 64393 - Approval of Noise Compatibility Program for Chicago Executive Airport, Prospect Heights and...

Science.gov (United States)

2010-10-19

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Approval of Noise Compatibility Program for Chicago Executive Airport, Prospect Heights and Wheeling, IL AGENCY: Federal Aviation Administration, DOT. ACTION: Notice. SUMMARY: The Federal Aviation Administration (FAA) announces its findings on...

The Vasodilator Effect of a Cream Containing 10% Menthol and 15% Methyl Salicylate on Random-Pattern Skin Flaps in Rats.

Science.gov (United States)

Dölen, Utku Can; Sungur, Nezih; Koca, Gökhan; Ertunç, Onur; Bağcı Bosi, Ayşe Tülay; Koçer, Uğur; Korkmaz, Meliha

2015-11-01

It is still difficult to prevent partial or full-thickness flap necrosis. In this study, the effects of a cream containing menthol and methyl salicylate on the viability of randompattern skin flaps were studied. Forty female Sprague-Dawley rats were divided into two equal groups. Caudally based dorsal random-pattern skin flaps were elevated, including the panniculus carnosus. In the study group, 1.5 mL of a cream containing menthol and methyl salicylate was applied to the skin of the flap, and saline solution (0.9%) was used in the control group. Upon completion of the experiment, flap necrosis was analyzed with imaging software and radionuclide scintigraphy. Histopathological measurements were made of the percentage of viable flaps, the number of vessels, and the width of the panniculus carnosus muscle. According to the photographic analysis, the mean viable flap surface area in the study group was larger than that in the control group (P=0.004). According to the scintigrams, no change in radioactivity uptake was seen in the study group (P>0.05). However, a significant decrease was observed in the control group (P=0.006). No statistically significant differences were observed between the groups in terms of the percentage of viable flaps, the number of vessels, or the width of the panniculus carnosus muscle (P>0.05). Based on these results, it is certain that the cream did not reduce the viability of the flaps. Due to its vasodilatory effect, it can be used as a component of the dressing in reconstructive operations where skin perfusion is compromised.

Lean and Efficient Software: Whole-Program Optimization of Executables

Science.gov (United States)

2015-09-30

Lean and Efficient Software: Whole-Program Optimization of Executables” Project Summary Report #5 (Report Period: 7/1/2015 to 9/30/2015...TYPE 3. DATES COVERED 00-00-2015 to 00-00-2015 4. TITLE AND SUBTITLE Lean and Efficient Software: Whole-Program Optimization of Executables 5a...unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Lean and Efficient Software: Whole-Program

Executive summary. Session summaries

International Nuclear Information System (INIS)

2011-01-01

The possibility of stopping and/or delaying the progression of a core melt accident by the use of a recovered water source or by taking benefit of specific engineered systems is taken into account in a number of PSA (Probabilistic Safety Assessment) studies. The likelihood to stop the progression of a core melt-down accident by water injection is generally considered as high in the early phase of core degradation and depends on reactor specific features, nevertheless even in later sequences, e.g. during the relocation in the lower head, cooling still can be achieved but depends on reactor specific features and the accident scenario.. Ongoing, starting and planned experimental programmes address the coolability issues in the different relevant configurations, i.e. reflooding of bundles, debris beds, molten pools and Reactor Pressure Vessel external cooling. There is still a difficulty with present models to predict reliably if reflooding during the early core degradation would or not trigger a cladding oxidation runaway. Whether this is due to deficiencies in thermal-hydraulics description or problems for taking into account the oxidation of melts is a matter of discussion. The code developments are promisingly directed towards a more mechanistic approach using a porous medium modelling able to treat the different configurations of a degraded core. Secondly, the models to describe adequately the relocation of parts of the molten core to the lower head and the debris bed formation still need further development and qualification. Their validation is expected against the results of ongoing experimental programmes. The transposition of results to the reactor scale where multi-dimensional effects are expected needs to be evaluated, all the more as larger scale experiments are probably not feasible

Clinical Practice Guideline: Improving Nasal Form and Function after Rhinoplasty Executive Summary.

Science.gov (United States)

Ishii, Lisa E; Tollefson, Travis T; Basura, Gregory J; Rosenfeld, Richard M; Abramson, Peter J; Chaiet, Scott R; Davis, Kara S; Doghramji, Karl; Farrior, Edward H; Finestone, Sandra A; Ishman, Stacey L; Murphy, Robert X; Park, John G; Setzen, Michael; Strike, Deborah J; Walsh, Sandra A; Warner, Jeremy P; Nnacheta, Lorraine C

2017-02-01

Objective Rhinoplasty, a surgical procedure that alters the shape or appearance of the nose while preserving or enhancing the nasal airway, ranks among the most commonly performed cosmetic procedures in the United States, with >200,000 procedures reported in 2014. While it is difficult to calculate the exact economic burden incurred by rhinoplasty patients following surgery with or without complications, the average rhinoplasty procedure typically exceeds $4000. The costs incurred due to complications, infections, or revision surgery may include the cost of long-term antibiotics, hospitalization, or lost revenue from hours/days of missed work. The resultant psychological impact of rhinoplasty can also be significant. Furthermore, the health care burden from psychological pressures of nasal deformities/aesthetic shortcomings, surgical infections, surgical pain, side effects from antibiotics, and nasal packing materials must also be considered for these patients. Prior to this guideline, limited literature existed on standard care considerations for pre- and postsurgical management and for standard surgical practice to ensure optimal outcomes for patients undergoing rhinoplasty. The impetus for this guideline is to utilize current evidence-based medicine practices and data to build unanimity regarding the peri- and postoperative strategies to maximize patient safety and to optimize surgical results for patients. Purpose The primary purpose of this guideline executive summary is to provide evidence-based recommendations for clinicians who either perform rhinoplasty or are involved in the care of a rhinoplasty candidate, as well as to optimize patient care, promote effective diagnosis and therapy, and reduce harmful or unnecessary variations in care. The target audience is any clinician or individual, in any setting, involved in the management of these patients. The target patient population is all patients aged ≥15 years. The guideline is intended to focus on

Weapons-grade plutonium dispositioning. Volume 1: Executive summary

International Nuclear Information System (INIS)

Parks, D.L.; Sauerbrun, T.J.

1993-06-01

The Secretary of Energy requested the National Academy of Sciences (NAS) Committee on International Security and Arms Control to evaluate dispositioning options for weapons-grade plutonium. The Idaho National Engineering Laboratory (INEL) assisted NAS in this evaluation by investigating the technical aspects of the dispositioning options and their capability for achieving plutonium annihilation levels greater than 90%. Additionally, the INEL investigated the feasibility of using plutonium fuels (without uranium) for disposal in existing light water reactors and provided a preconceptual analysis for a reactor specifically designed for destruction of weapons-grade plutonium. This four-volume report was prepared for NAS to document the findings of these studies. Volume 2 evaluates 12 plutonium dispositioning options. Volume 3 considers a concept for a low-temperature, low-pressure, low-power-density, low-coolant-flow-rate light water reactor that quickly destroys plutonium without using uranium or thorium. This reactor concept does not produce electricity and has no other mission than the destruction of plutonium. Volume 4 addresses neutronic performance, fabrication technology, and fuel performance and compatibility issues for zirconium-plutonium oxide fuels and aluminum-plutonium metallic fuels. This volumes gives summaries of Volumes 2--4

Summaries of FY 1994 engineering research

International Nuclear Information System (INIS)

1994-12-01

This report documents the Basic Energy Sciences Engineering Research Program for fiscal year 1994; it provides a summary of each of the program projects in addition to a brief program overview. The report is intended to provide staff of Congressional committees, other executive departments, and other DOE offices with substantive program information so as to facilitate governmental overview and coordination of Federal research programs. Of equal importance, its availability facilitates communication of program information to interested research engineers and scientists

Summaries of FY 1994 engineering research

Energy Technology Data Exchange (ETDEWEB)

1994-12-01

This report documents the Basic Energy Sciences Engineering Research Program for fiscal year 1994; it provides a summary of each of the program projects in addition to a brief program overview. The report is intended to provide staff of Congressional committees, other executive departments, and other DOE offices with substantive program information so as to facilitate governmental overview and coordination of Federal research programs. Of equal importance, its availability facilitates communication of program information to interested research engineers and scientists.

Final summary report of the Nordic Nuclear Safety Research Program 1994 - 1997; Sammanfattning av det nordiska forskningsprogrammet foer kaernsaekerhet

Energy Technology Data Exchange (ETDEWEB)

Bennerstedt, T.; Lemmens, A. [eds.

1999-11-01

This is a summary report of the NKS research program carried out 1994 - 1997. It is basically a compilation of the executive summaries of the final reports on the nine scientific projects carried out during that period. It highlights the conclusions, recommendations and other results of the projects. (au)

The Vasodilator Effect of a Cream Containing 10% Menthol and 15% Methyl Salicylate on Random-Pattern Skin Flaps in Rats

Directory of Open Access Journals (Sweden)

Utku Can Dölen

2015-11-01

Full Text Available BackgroundIt is still difficult to prevent partial or full-thickness flap necrosis. In this study, the effects of a cream containing menthol and methyl salicylate on the viability of randompattern skin flaps were studied.MethodsForty female Sprague-Dawley rats were divided into two equal groups. Caudally based dorsal random-pattern skin flaps were elevated, including the panniculus carnosus. In the study group, 1.5 mL of a cream containing menthol and methyl salicylate was applied to the skin of the flap, and saline solution (0.9% was used in the control group. Upon completion of the experiment, flap necrosis was analyzed with imaging software and radionuclide scintigraphy. Histopathological measurements were made of the percentage of viable flaps, the number of vessels, and the width of the panniculus carnosus muscle.ResultsAccording to the photographic analysis, the mean viable flap surface area in the study group was larger than that in the control group (P=0.004. According to the scintigrams, no change in radioactivity uptake was seen in the study group (P>0.05. However, a significant decrease was observed in the control group (P=0.006. No statistically significant differences were observed between the groups in terms of the percentage of viable flaps, the number of vessels, or the width of the panniculus carnosus muscle (P>0.05.ConclusionsBased on these results, it is certain that the cream did not reduce the viability of the flaps. Due to its vasodilatory effect, it can be used as a component of the dressing in reconstructive operations where skin perfusion is compromised.

Effects of a multicomponent exercise on dual-task performance and executive function among older adults

Directory of Open Access Journals (Sweden)

Ray-Yau Wang

2018-06-01

Full Text Available Summary: Background: Previous studies showed that multicomponent exercise enhanced physical and cognitive functions. This study aimed to investigate the effects of a multicomponent exercise on dual-task performance and executive function and to demonstrate the relationship between improvement in dual-task performance and enhancement in executive function among the elderly. Methods: A total of 27 people completed the intervention, with 16 in the experimental group and 11 in the control group. The 12-week multicomponent exercise lasted 1 h per day and 3 days per week. Participants' gait performance was assessed in dual-task conditions and executive function was examined at both pre- and post-intervention. Results: Results showed significant interaction effects of time x group on all selected gait parameters in both dual-task conditions and the Executive Interview. Compared with the control group, the experimental group showed greater improvements in most measures following intervention. Improved dual-task performance was correlated with enhanced executive function (r = 0.46–0.75. Conclusion: Our results suggested that a multicomponent exercise positively affects dual-task performance and executive function in the elderly. Keywords: Dual-task, Executive function, Exercise, Gait, Older adults

Final Report: Summary of Findings and Recommendations for Suction Devices for Management of Prehospital Combat Casualty Care Injuries

Science.gov (United States)

2017-11-13

Airway Final Report: Summary of Findings and Recommendations for Suction Devices for Management of Prehospital Combat Casualty Care Injuries...Consumer Style Comparison Table of Suction Pump Devices ............................. 103 Appendix H – Web Links for Images for Consumer- Style ...0022 pg. 6 Executive Summary Suction is a critical component of airway management , which is the second leading cause of preventable

Waste Isolation Pilot Plant transuranic wastes experimental characterization program: executive summary

International Nuclear Information System (INIS)

Molecke, M.A.

1978-11-01

A general overview of the Waste Isolation Pilot Plant transuranic wastes experimental characterization program is presented. Objectives and outstanding concerns of this program are discussed. Characteristics of transuranic wastes are also described. Concerns for the terminal isolation of such wastes in a deep bedded salt facility are divided into two phases, those during the short-term operational phase of the facility, and those potentially occurring in the long-term, after decommissioning of the repository. An inclusive summary covering individual studies, their importance to the Waste Isolation Pilot Plant, investigators, general milestones, and comments are presented

Executive summary

International Nuclear Information System (INIS)

Anon.

1991-01-01

This is a report on studies that value the environmental impacts resulting from generation and conservation of electric power. The purpose is to review the literature on the methodologies used to assign monetary costs to environmental externalities and to present the results of studies which have applied these methodologies. For those environmental damages for which the literature has not established a value, the report identifies the indicated ranges of adverse effects and provides a road map of issues that require research. The report is intended to assist utilities, government regulators, legislators, policy analysts and public interest groups in estimating the costs of the environmental impacts of electricity. It should be useful, as well, to assist in valuing the environmental impacts of pollutants from other industries, for setting environmental control standards, and in establishing pollution taxes or fees

Executive Summary

International Nuclear Information System (INIS)

Plompen, A.; Woznicka, U.; Dupont, E.

2011-01-01

In the session on data needs and impact, the use of sensitivity studies is highlighted to determine lists of nuclides requiring reduced uncertainty according to the type of activities: reactor design or waste management. In the session on nuclear data validation nuclear databases like ENDF/B-VII, JENDL-3.3 and JEFF-3.1.1 were confronted to some experimental results. During the workshop new experimental setups and measurement methodologies were presented particularly for (n, xng), (n,t) reactions and deuteron-induced activation reactions and fission yields

Executive summary

International Nuclear Information System (INIS)

Besmann, T.M.

2015-01-01

The State-of-the-Art Report on Multi-scale Modelling of Nuclear Fuels describes the state of fundamental materials models that can represent fuel behaviour, the methodologies for obtaining material properties, and modelling principles as they can be implemented in fuel performance codes. This report, while far from being a detailed assessment of nuclear fuel modelling, provides a recognition of the approaches to the significant aspects of fuel modelling and examples of their application. Fuel behaviour phenomena are discussed that are applicable across the spectrum of fuel forms, from conventional LWR oxide pellets to MOX, carbide, and metal SFR fuel, to coated particle fuel for gas-cooled reactors. A key issue is microstructural evolution during burn-up, and the state of understanding of that phenomenon is considered at length. Covered in the discussions are the basic material properties of heat capacity, free energy, and thermal conductivity and diffusion. Also included are the more functional effects of restructuring, bubble formation, constituent redistribution, fuel and clad oxidation, and fuel clad and environmental interactions. Fuel fabrication is considered as are many material modelling challenges, such as representing injection casting of metallic fuels, as seen in the preparation of nuclear fuel. The last set of contributions covered the basic principles for modelling phenomena and determining fundamental materials properties, a look at the state of fuel performance codes and a last note about integrating across multiple scales. The state-of-the-art of modelling phenomena related to nuclear fuel has advanced significantly in recent years. The representation of atomic level behaviour is increasingly becoming more accurate as capabilities to utilise larger sets of atoms evolve and empirical potentials improve. At the mesoscale, models for transport and microstructure evolution have also progressed with new techniques that well represent restructuring. At the macro-scale, the lower scale representations inform models that reproduce observed fuel behaviour. Significant challenges do remain in both improving the models and in their multi-scale integration, and thus there is still much to be done. However, it is the expectation that as the problems of fuel modelling and simulation are solved, predictive models will increasingly find their way into advanced fuel performance codes and allow the eventual realistic simulation of nuclear fuel behaviour under normal and accident conditions that goes beyond empirical correlations. (author)

Executive summary

Science.gov (United States)

Susan H. Julius; Jordan M. West; Geoffrey M. Blate; Jill S. Baron; Brad Griffith; Linda A. Joyce; Peter Kareiva; Brian D. Keller; Margaret A. Palmer; Charles H. Peterson; J. Michael. Scott

2008-01-01

This report provides a preliminary review of adaptation options for climate-sensitive ecosystems and resources in the United States. The term “adaptation” in this document refers to adjustments in human social systems (e.g., management) in response to climate stimuli and their effects. Since management always occurs in the context of desired ecosystem conditions or...

Executive summary

Science.gov (United States)

Peter Backlund; Anthony Janetos; David Schimel; J. Hatfield; M. Ryan; S. Archer; D. Lettenmaier

2008-01-01

This report is an assessment of the effects of climate change on U.S. land resources, water resources, agriculture, and biodiversity. It is one of a series of 21 Synthesis and Assessment Products being produced under the auspices of the U.S. Climate Change Science Program (CCSP), which coordinates the climate change research activities of U.S. government agencies. The...

Executive summary

International Nuclear Information System (INIS)

Christy, Robert F.; Tajima, Eizo

1987-01-01

The Historical Review describes the events leading up to the present reassessment of the dosimetry of the atomic bombs at Hiroshima and Nagasaki. To make that reassessment, working groups were set up in Japan and in the United States. These groups organized their efforts into ten major areas: yields of the bombs, radiation leakage from the bombs, transport of radiation in air over ground, thermoluminescence measurements of gamma rays, measurements of neutrons, residual radioactivity, house and terrain shielding, organ dosimetry, preparation of a dosimetry system, and uncertainty analysis. In this report on the reassessment, one chapter is devoted to each of the first nine areas; a future will deal with the last area, uncertainty analysis. The chapters were prepared by writing groups, listed as the authors of the chapters. The chapters are based on a large number of individual papers, some of which are included in this report as appendixes to the relevant chapters

Executive summary

DEFF Research Database (Denmark)

Bangsbo, Jens; Junge, A; Dvorak, J

2014-01-01

and women with type 2 diabetes. Furthermore, muscle mass and bone mineral density increases in a number of participant groups, including 65-75-year-old men. The functional capacity is elevated with increases in VO2 max of 10-15%, and 50-100% improvements in the capacity to perform intermittent work within...... structure and improves its function. Blood pressure is markedly reduced with the mean arterial blood pressure being lowered by ~10 mmHg for hypertensive men and women training 2-3 times/week for 12-26 weeks. Triglycerides and cholesterol are lowered and body fat declines, especially in middle-aged men...

Executive summary

International Nuclear Information System (INIS)

2014-01-01

The workshop included an opening session, six sessions with participant presentations followed by short discussion, and two facilitated discussion sessions. The contributions presented were devoted to new methodological developments, projects with external hazards analysis activities, interesting aspects of external hazards analysis and expected challenges for future analyses. The contributions presented and the discussions organized during the workshop provided valuable input for strengthening the role of WGRISK in supporting the development and application of probabilistic safety assessment and risk-oriented decision making methods in the area of external hazards. The workshop supported the key general objectives of collecting and exchanging information from OECD member states on the methods and approaches used in probabilistic safety assessment in this area. The focus of the workshop was on external events PSA for nuclear power plants, including all modes of operation. The workshop scope was generally limited to external, natural hazards, including those hazards where the distinction between natural and man-made hazards is not sharp (e.g., external floods caused by dam failures). The participation was open to experts from regulatory authorities and their technical support organizations, research organizations, utilities, nuclear power plant (NPP) designers and vendors, industry associations and observers from OECD NEA member countries. The Background, Objectives, Organization, and Topics of the Workshop are presented in chapter 1. The WGRISK activities preceding the workshop and leading to the decision to organize it are described in Chapter 2. The detailed information about the presentations, discussions, and results of the workshop is presented in Chapter 3. Detailed information about the conclusions made during the workshop is presented in Chapter 4. The list of participants, the workshop agenda and the papers/presentations are attached in the appendixes

Executive Summary

International Nuclear Information System (INIS)

2012-01-01

The OECD Nuclear Energy Agency (NEA) Integration Group for the Safety Case (IGSC) organised a workshop to assess current understanding on the use of cementitious materials in radioactive waste disposal. The workshop was hosted by the Belgian Agency for Radioactive Waste and Enriched Fissile Materials (Ondraf/Niras), in Brussels, Belgium on 17-19 November 2009. The workshop brought together a wide range of people involved in supporting safety case development and having an interest in cementitious materials: namely, cement and concrete experts, repository designers, scientists, safety assessors, disposal programme managers and regulators. The workshop was designed primarily to consider issues relevant to the post-closure safety of radioactive waste disposal, but also addressed some related operational issues, such as cementitious barrier emplacement. Where relevant, information on cementitious materials from analogous natural and anthropogenic systems was also considered. The workshop agenda is included as Appendix A. The workshop focused on: - The uses of different cementitious materials in various repository designs. - The evolution of cementitious materials over long time scales (1000s to 100000s of years). - The interaction of cementitious materials with surrounding components of the repository (e.g. waste, container, buffer, backfill, host rock). - The workshop comprised: - Plenary sessions in which the state-of-the-art on repository design and understanding the phenomenology of cementitious materials and their interactions were presented and discussed. - Dedicated working group sessions, which were used to discuss key safety assessment and safety case questions in more detail. For example: How strong is the scientific basis for incorporating the various aspects of the behaviour and interactions of cementitious materials in safety assessments and safety cases? How can the behaviour and interactions of cementitious materials best be incorporated within the safety case, and how can the safety case be used to help inform repository design choices? Which are the main open questions and uncertainties? In preparation for the workshop, a review was undertaken to identify and describe relevant examples of the use and functions of cementitious materials in geological disposal concepts from a range of settings. In accordance with the intent of the workshop, the review covered geological disposal concepts for high-level wastes (HLW) and spent fuel, as well as for intermediate-level wastes (ILW) and their equivalents. Abstracts and supporting papers for oral presentations and posters presented at the workshop are included as Appendices C and D. This report provides a synthesis of the workshop, and summarises its main results and findings. The structure of this report follows the workshop agenda: - Section 2 summarises plenary and working group discussions on the uses, functions and evolution of cementitious materials in geological disposal, and highlights key aspects and discussions points. - Section 3 summarises plenary and working group discussions on interactions of cementitious materials with other disposal system components, and highlights key aspects and discussions points. - Section 4 summarises the workshop session on the integration of issues related to cementitious materials using the safety case. - Section 5 presents the main conclusions from the workshop. - Section 6 contains a list of references. - Appendix A presents the workshop agenda. - Appendix B contains the abstracts and, where provided, technical papers supporting oral presentations at the workshop. - Appendix C contains the abstracts and, where provided, technical papers supporting posters presented at the workshop. - Appendix D records the workshop participants and the composition of the working groups

Executive Summary

International Nuclear Information System (INIS)

2015-01-01

The 13. Information Exchange Meeting was held in Seoul (Republic of Korea) on 23-26 September 2014, hosted by Seoul National University. The workshop comprised a plenary session on national and international programmes followed by technical sessions and a poster session covering various aspects of P and T. The information exchange meetings on P and T form a part of the NEA programme of work in the field of advanced nuclear fuel cycles. These proceedings include papers presented at the 13. Information Exchange Meeting. The meeting covered strategic and scientific developments in the field of P and T such as: fuel cycle strategies and transition scenarios, the role of P and T in the potential evolution of nuclear energy as part of the future energy mix; radioactive waste management strategies; transmutation fuels and targets; advances in pyro and aqueous separation processes; P and T specific technology requirements (materials, spallation targets, coolants, etc.); transmutation systems: design, performance and safety; impact of P and T on the fuel cycle; fabrication, handling and transportation of transmutation fuels. A total of 103 presentations (39 oral and 64 posters) were discussed among the 110 participants from 19 countries and 2 international organisations. The meeting consisted of one plenary session where national and international programmes were presented followed by 5 technical sessions: - Fuel Cycle Strategies and Transition Scenarios; - Transmutation Systems and Infrastructures; - Waste Management for P and T Scenarios; - Advanced Nuclear Fuel Recycling (Aqueous and Pyro-processing); - Transmutation Fuels and Targets

Executive Summary

DEFF Research Database (Denmark)

Elf, Nikolaj Frydensbjerg

2017-01-01

Rekvireret forskningsrapport for Undervisningsministeriet (UVM) som afrapporterer forundersøgelsesfasen for danskfagets vedkommende i projekt Kvalitet i dansk og matematik. Har været til gennemsyn inden udgivelse hos UVM....

Executive summary

International Nuclear Information System (INIS)

2015-01-01

Since 2007, the OECD Nuclear Energy Agency has been organising a series of workshops on Structural Materials for Innovative Nuclear Systems. The third meeting was held on 7-9 October 2013 in Idaho Falls (United States). The main objectives of this workshop are to stimulate an exchange of information on current materials R and D programmes for different innovative nuclear systems. The main topics of the workshop covered fundamental studies, modelling and experiments on innovative structural materials including cladding materials for the range of advanced nuclear systems such as thermal/fast systems, sub-critical systems, as well as fusion systems. During the workshop, the following topics were discussed: - Fundamental studies; - Metallic materials; - Ceramic materials; - Novel materials pathways; - Ion vs neutron irradiation. Fundamental studies focused on the identification of mechanisms driving the response of materials under the conditions expected in innovative nuclear systems. These mechanisms may have acted at the atomic or higher scale with the application of multi-scale approaches, together with related problems of scale-bridging or numerical methods, were of special interest. Moreover, irradiation experiments and subsequent characterisation of materials with analytical techniques were included in the session if aimed at better understanding the acting mechanisms or drawing physics-based correlations. Metal alloys, ceramic and ceramic composites included in- and out-of-core applications which took into account the scope of: data availability and gaps (considering also licensing issues); experimental and modelling needs for specific components or degradation modes; the link between R and D, standardisation and experimental protocols; coolant effects and mechanical properties. Code development and implementation plans were also discussed. Application of SiC composites to LWR systems was of interest as an advanced concept. Novel materials pathways considered routes to fabricate materials and components for innovative nuclear systems. The 'ions vs. neutron irradiation' topic focused on specific irradiation comparisons including mechanical properties and microstructural effects caused by ion or neutron irradiation. Comparative irradiation studies on a common material were also welcome. Fuel-cladding interaction was not covered in this edition of the workshop. The workshop received 74 abstracts, and was scheduled with 5 invited talks, 27 oral presentations and 2 poster sessions (42 posters) from 75 registered participants. However, it was necessary to reorganise the programme at extremely short notice to take into account the effects of the unexpected US government shutdown and the constraints this imposed on the workshop. In total, 38 participants from 12 countries and 2 international organisations attended, and the final number of presentations amounted to 51 (22 oral presentations and 29 posters). The re-scheduled workshop opened with the welcome address by S. Cornet on behalf of the OECD Nuclear Energy Agency followed by technical sessions: Session I: Overview on programmes and metal alloys. Session II: Metal alloys. Session III: Novel pathways. Session IV: Ceramic composites, ions vs. neutrons and general

Executive Summary

International Nuclear Information System (INIS)

Vari, Anna; Sakuma, Hideki

2008-01-01

Within the radioactive waste management community it is now broadly agreed that any decision making will, and should, take place in stages. This allows for better use of current knowledge, for further knowledge to be generated, and for increased opportunity for collective learning and self-training of the various actors. In this process each actor must feel the ability to influence the decision making process, including generating complementary investigations on topics of significance in the field of safety and regarding the long-term impacts. In the technical field of the long-term safety case for disposal it is specifically acknowledged that a safety case (SC) is built in stages, and that it should recognise, at each stage, the open issues and the relevant role of research, development and demonstration (RD and D). It is also acknowledged, in connection with the SC, that stakeholders have a role to play as partners or reviewers and, ultimately, can help to shape the concept of safety. Because today the issue is no longer how to implement an economically-optimal project of waste storage or disposal on a site imposed by the authorities, new challenges are posed to the technical community and to the roles and approaches they take. Important questions are: 1. How to improve on the interaction between science and society, and ensure opportunities for societal direction of RD and D? 2. How to clearly and effectively communicate scientific findings and uncertainties and/or address contradictory views of process participants? Alternatively, how to communicate confidence in the results so far and in the process of acquiring those results? 3. How to encourage 'stretching' of specialists for disclosure of interests, greater transparency, broader dialogue, and to ensure rigour of research programmes? On June 6, 2007 a Topical Session to discuss the above questions was held at OECD NEA. Presentations were invited from delegates of five RWM organisations, including SKI and KASAM (Sweden), NRC (USA), NWMO (Canada), and HSK (Switzerland), as well as representatives of NEA and its working parties the Integration Group for the Safety Case (IGSC) and the Regulators? Forum. Presentations, discussions, and lessons learned are summarised in this paper

A time-series approach to random number generation: Using recurrence quantification analysis to capture executive behavior

Directory of Open Access Journals (Sweden)

Wouter eOomens

2015-06-01

Full Text Available The concept of executive functions plays a prominent role in contemporary experimental and clinical studies on cognition. One paradigm used in this framework is the random number generation (RNG task, the execution of which demands aspects of executive functioning, specifically inhibition and working memory. Data from the RNG task are best seen as a series of successive events. However, traditional RNG measures that are used to quantify executive functioning are mostly summary statistics referring to deviations from mathematical randomness. In the current study, we explore the utility of recurrence quantification analysis (RQA, a nonlinear method that keeps the entire sequence intact, as a better way to describe executive functioning compared to traditional measures. To this aim, 242 first- and second-year students completed a non-paced RNG task. Principal component analysis of their data showed that traditional and RQA measures convey more or less the same information. However, RQA measures do so more parsimoniously and have a better interpretation.

A eficácia do mentol como anestésico para tambaqui (Colossoma macropomum, Characiformes: Characidae Efficacy of menthol as an anesthetic for tambaqui (Colossoma macropomum, Characiformes: Characidae

Directory of Open Access Journals (Sweden)

Michelle Ferreira Façanha

2005-01-01

Full Text Available Os anestésicos são importantes na piscicultura para reduzir o estresse e a mortalidade no manejo. Este trabalho tem como objetivo determinar a eficácia do mentol para tambaqui durante o manejo. Na primeira série de testes, foi examinado o efeito da concentração de anestésico sobre indução à anestesia e o estresse de tambaqui. Na segunda série de testes, foi avaliada a recuperação dos peixes após a exposição a uma concentração de 150 mg/L de mentol por diferentes tempos. Na terceira série, foi avaliada se a melhor concentração encontrada para juvenil (150 mg/L também era adequada para peixes maiores. A melhor concentração para uma anestesia cirúrgica foi 150 mg/L, pois o tempo de indução é rápido, porém a recuperação é significativamente mais demorada do que para as menores concentrações testadas. Para uma anestesia, com finalidade de biometria, a melhor concentração foi 100 mg/L. Nesta concentração o tempo de indução à anestesia é prolongado, porém o tempo de recuperação está dentro da faixa considerada adequada. O tempo de recuperação do tambaqui quando exposto a 150 mg/L é significativamente igual para 10, 20 e 30 minutos de anestesia. Os resultados obtidos mostram que o mentol é um anestésico eficiente para o tambaqui.Anesthetics are important in fish culture to reduce handling stress and mortality. The objective of this work is to investigate menthol as an anesthetic for tambaqui. In the first series of tests, fish were exposed to various concentrations of menthol to evaluate induction time and stress responses. The second series examined the effect of exposure period to menthol at 150 mg/L on recovery time. The third assessed the best dosage for juveniles in larger tambaqui. The best concentration for surgical anesthesia is 150 mg/L. At this concentration the induction time is short, but their recovery time is significantly longer than that for lower concentrations. For biometry procedures

Dandruff, seborrheic dermatitis, and psoriasis drug products containing coal tar and menthol for over-the-counter human use; amendment to the monograph. Final rule

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-03-15

The Food and Drug Administration (FDA) is issuing a final rule amending the final monograph (FM) for over-the-counter (OTC) dandruff, seborrheic dermatitis, and psoriasis drug products to include the combination of 1.8 percent coal tar solution and 1.5 percent menthol in a shampoo drug product to control dandruff. FDA did not receive any comments or data in response to its previously proposed rule to include this combination. This final rule is part of FDA's ongoing review of OTC drug products.

Mentol e eugenol como substitutos da benzocaína na indução anestésica de juvenis de pacu = Menthol and eugenol as benzocaine substitutes in anesthetic induction of pacu juveniles

Directory of Open Access Journals (Sweden)

André Fernando Nascimento Gonçalves

2008-07-01

Full Text Available Objetivou-se verificar a eficiência de anestésicos naturais na indução à anestesia de juvenis de pacu. Foram avaliadas quatro concentrações de mentol (50, 100, 150 e 200 mg L-1, quatro de eugenol (10, 25, 50 e 100 mg L-1 e uma de benzocaína (100 mg L-1. Durante o procedimento de anestesia, foram monitorados e avaliados quatro estágios de sedação, da redução dos movimentos operculares até a perda total de reação à manipulação. Após o procedimento de biometria, foram avaliados o tempo de recuperação e a mortalidade até48h após anestesia. As concentrações de 100, 150 e 200 mg L-1 de mentol e as concentrações de 50 e 100 mg L-1 de eugenol apresentaram tempos de indução à anestesia e recuperação similares aos da benzocaína. Os resultados obtidos mostraram que o mentol e o eugenol são anestésicos eficientes para pacus em substituição à benzocaína, sugerindo a concentração de 100 mg L-1 de mentol e 50 mg L-1 de eugenol.This study aimed to verify the efficacy of natural anestheticinduction of pacu juveniles. Were evaluated four menthol (50, 100, 150 and 200 mg L-1, four eugenol (10, 25, 50 and 100 mg L-1 and one benzocaine (100 mg L-1 concentrations. During the anesthetic procedure, four sedative stages were monitored and evaluated until no reaction of the fish to handling was registered. After performingbiometric evaluation on the anesthetized fish, were recorded the recovery time and mortality rate up to 48 hours after the anesthetic experiments. Concentrations of 100, 150 and 200 mg L-1 of menthol, 50 and 100 mg L-1 of eugenol showed anesthetic induction timeand recovery time similar to that of benzocaine. The obtained results showed that menthol and eugenol are efficient anesthetics for pacu juveniles in substitution of benzocaine, suggesting the concentration of 100 mg L-1 of menthol and 50 mg L-1 of eugenol.

EXECUTIVE SUMMARY OF THE SNOWMASS 2001 WORKING GROUP : ELECTROWEAK SYMMETRY BREAKING

International Nuclear Information System (INIS)

CARENA, M.; GERDES, D.W.; HABER, H.E.; TURCOT, A.S.; ZERWAS, P.M.

2001-01-01

In this summary report of the 2001 Snowmass Electroweak Symmetry Breaking Working Group, the main candidates for theories of electroweak symmetry breaking are surveyed, and the criteria for distinguishing among the different approaches are discussed. The potential for observing electroweak symmetry breaking phenomena at the upgraded Tevatron and the LHC is described. We emphasize the importance of a high-luminosity e + e - linear collider for precision measurements to clarify the underlying electroweak symmetry breaking dynamics. Finally, we note the possible roles of the μ + μ - collider and VLHC for further elucidating the physics of electroweak symmetry breaking

Executive Functioning in Men with Schizophrenia and Substance Use Disorders. Influence of Lifetime Suicide Attempts.

Directory of Open Access Journals (Sweden)

Ana Adan

Full Text Available Lifetime suicide attempts in patients with comorbidity between psychotic disorders and Substance Use Disorder (SUD, known as dual diagnosis, was associated with a worse clinical and cognitive state, poor prognosis and premature death. However, to date no previous study has examined the cognitive performance of these patients considering as independent the presence or absence of lifetime suicide attempts.We explore executive functioning differences between suicide attempters and non-attempters in dual schizophrenia (DS patients and the possible related factors for both executive performance and current suicide risk. Fifty DS male patients in remission of SUD and clinically stables, 24 with and 26 without lifetime suicide attempts, were evaluated. We considered Z scores for all neuropsychological tests and a composite summary score for both premorbid IQ and executive functioning.DS patients showed low performance in set-shifting, planning and problem solving tasks. Those with suicide attempts presented lower composite summary scores, together with worse problem solving skills and decision-making, compared with non-attempters. However, after controlling for alcohol dependence, only differences in decision-making remained. Executive functioning was related to the premorbid intelligence quotient, and several clinical variables (duration, severity, months of abstinence and relapses of SUD, global functioning and negative symptoms. A relationship between current suicide risk, and first-degree relatives with SUD, insight and positive symptoms was also found.Our results suggest that problem solving and, especially, decision-making tasks might be sensitive to cognitive impairment of DS patients related to presence of lifetime suicide attempts. The assessment of these executive functions and cognitive remediation therapy when necessary could be beneficial for the effectiveness of treatment in patients with DS. However, further research is needed to expand

U.S. Army Deployment Injury Surveillance Summary, CY 2007 1 January 2007 - 31 December 2007

Science.gov (United States)

2007-12-31

percent), football (15 percent), PT (15 percent), and weightlifting (14 percent). 8 Injury Prevention Report No. 12-HF-OAN7A-09, 1 Jan -31 Dec 07...Washington, DC 20310 SUBJECT: Injury Prevention Report No. 12-HF-OAN7A-09, US Army Deployment Injury Surveillance Summary, CY 2007. 1. We are enclosing a...copy of the subject report with an Executive Summary. The ASA(I&E) provided initial funding in 2004 for the USACHPPM to conduct deployment injury

Summaries of FY 1982 research in the chemical sciences

Energy Technology Data Exchange (ETDEWEB)

None

1982-09-01

The purpose of this booklet is to help those interested in research supported by the Department of Energy's Division of Chemical Sciences, which is one of six Divisions of the Office of Basic Energy Sciences in the Office of Energy Research. These summaries are intended to provide a rapid means for becoming acquainted with the Chemical Sciences program to members of the scientific and technological public and interested persons in the Legislative and Executive Branches of the Government. Areas of research supported by the Division are to be seen in the section headings, the index and the summaries themselves. Energy technologies which may be advanced by use of the basic knowledge discovered in this program can be seen in the index and again (by reference) in the summaries. The table of contents lists the following: photochemical and radiation sciences; chemical physics; atomic physics; chemical energy; separation and analysis; chemical engineering sciences; offsite contracts; equipment funds; special facilities; topical index; institutional index for offsite contracts; investigator index.

Summaries of FY 1982 research in the chemical sciences

International Nuclear Information System (INIS)

1982-09-01

The purpose of this booklet is to help those interested in research supported by the Department of Energy's Division of Chemical Sciences, which is one of six Divisions of the Office of Basic Energy Sciences in the Office of Energy Research. These summaries are intended to provide a rapid means for becoming acquainted with the Chemical Sciences program to members of the scientific and technological public and interested persons in the Legislative and Executive Branches of the Government. Areas of research supported by the Division are to be seen in the section headings, the index and the summaries themselves. Energy technologies which may be advanced by use of the basic knowledge discovered in this program can be seen in the index and again (by reference) in the summaries. The table of contents lists the following: photochemical and radiation sciences; chemical physics; atomic physics; chemical energy; separation and analysis; chemical engineering sciences; offsite contracts; equipment funds; special facilities; topical index; institutional index for offsite contracts; investigator index

Bioenergy. The Impact of Indirect Land Use Change. Summary and Conclusions from the IEA Bioenergy ExCo63 Workshop

International Nuclear Information System (INIS)

Brown, A.; Tustin, J.

2009-09-01

This publication provides the summary and conclusions from the title workshop, held in conjunction with he meeting of the Executive Committee of IEA Bioenergy in Rotterdam, Netherlands, on 12 May 2009. The purpose of the workshop was to inform the Executive Committee on the rapidly evolving international debate on bioenergy and land use - particularly the thorny issue of indirect land use change. The aim was to stimulate discussion between the Executive Committee and invited experts and thereby enhance the new policy-oriented work within IEA Bioenergy.

Efficacy and safety profile of a topical methyl salicylate and menthol patch in adult patients with mild to moderate muscle strain: a randomized, double-blind, parallel-group, placebo-controlled, multicenter study.

Science.gov (United States)

Higashi, Yoshinobu; Kiuchi, Takehito; Furuta, Kenichi

2010-01-01

An occlusive patch formulation containing 10% methyl salicylate and 3% l-menthol was recently approved by the US Food and Drug Administration for the treatment of mild to moderate pain. Despite widespread use of counterirritants, including methyl salicylate and menthol, for topical pain relief, published efficacy and safety data regarding the use of the agents alone or in combination are limited. The goal of this study was to determine the efficacy and safety profile of a patch containing 10% methyl salicylate and 3% l-menthol compared with a placebo patch in adult patients with mild to moderate muscle strain. Eligible patients were men or women aged >or=18 years with a clinical diagnosis of mild to moderate muscle strain. Patients were randomly assigned to receive either 1 active patch or 1 placebo patch applied to the skin at the affected area (ie, shoulder, upper back, upper arm, neck, calf, thigh, forearm, abdomen). Pain intensity was assessed on a 100-mm visual analog scale while at rest and with movement for 12 hours after patch application. The primary efficacy end point was the summed pain intensity difference score through 8 hours (SPID8) with movement. Analyses included use of descriptive statistics and an ANOVA model. Safety data, including adverse events, and secondary efficacy end points were also evaluated. A total of 208 patients (104 men, 104 women; age range, 18-78 years) were randomized to 1 of 2 study groups (105 in the active-patch group [mean age, 37.3 years], 103 in the placebo-patch group [mean age, 38.1 years]). The primary efficacy analysis (SPID8 with movement) indicated that patients receiving the active patch experienced significantly greater pain relief (approximately 40%) than those patients receiving a placebo patch (mean [SD], 182.6 [131.2] vs 130.1 [144.1]; P = 0.005). Analysis of the per-protocol population also found significantly more relief (P = 0.024) in the active-patch group (176.2 [131.4]; n = 92) versus the placebo

The influence of executive capacity on selective attention and subsequent processing

Directory of Open Access Journals (Sweden)

Kirk R. Daffner

2012-06-01

Full Text Available Recent investigations that suggest selective attention is dependent on top-down control mechanisms lead to the expectation that individuals with high executive capacity would exhibit more robust neural indices of selective attention. This prediction was tested by using event-related potentials (ERPs to examine differences in markers of information processing across 25 subjects divided into 2 groups based on high vs. average executive capacity, as defined by neuropsychological test scores. Subjects performed an experimental task requiring selective attention to a specified color. In contrast to expectation, individuals with high and average executive capacity did not differ in the size of ERP indices of selective attention: the anterior Selection Positivity (SP and posterior Selection Negativity (SN. However, there were substantial differences between groups in markers of subsequent processing, including the anterior N2 (a measure of attentional control and the P3a (an index of the orienting of attention. Executive capacity predicted speed of processing at both early and late attentional stages. Individuals with lower executive capacity exhibited prolonged SN, P3a, and P3b latencies. However, the delays in carrying out selective attention operations did not account for subsequent delays in decision making, or explain excessive orienting and reduced attentional control mechanisms in response to stimuli that should have been ignored. SN latency, P3 latency, and the size of the anterior N2 made independent contributions to the variance of executive capacity. In summary, our findings suggest that current views regarding the relationship between top-down control mechanisms and selective attention may need refinement.

Nuclear Dynamics Consequence Analysis (NDCA) for the Disposal of Spent Nuclear Fuel in an Underground Geologic Repository--Volume 1: Executive Summary

International Nuclear Information System (INIS)

Taylor, L.L.; Wilson, J.R.; Sanchez, L.Z.; Aguilar, R.; Trellue, H.R.; Cochrane, K.; Rath, J.S.

1998-01-01

The US Department of Energy Office of Environmental Management's (DOE/EM's) National Spent Nuclear Fuel Program (NSNFP), through a collaboration between Sandia National Laboratories (SNL) and Idaho National Engineering and Environmental Laboratory (INEEL), is conducting a systematic Nuclear Dynamics Consequence Analysis (NDCA) of the disposal of SNFs in an underground geologic repository sited in unsaturated tuff. This analysis is intended to provide interim guidance to the DOE for the management of the SNF while they prepare for final compliance evaluation. This report presents results from a Nuclear Dynamics Consequence Analysis (NDCA) that examined the potential consequences and risks of criticality during the long-term disposal of spent nuclear fuel owned by DOE-EM. This analysis investigated the potential of post-closure criticality, the consequences of a criticality excursion, and the probability frequency for post-closure criticality. The results of the NDCA are intended to provide the DOE-EM with a technical basis for measuring risk which can be used for screening arguments to eliminate post-closure criticality FEPs (features, events and processes) from consideration in the compliance assessment because of either low probability or low consequences. This report is composed of an executive summary (Volume 1), the methodology and results of the NDCA (Volume 2), and the applicable appendices (Volume 3)

Fuego/Scefire MPMD Coupling L2 Milestone Executive Summary

Energy Technology Data Exchange (ETDEWEB)

Pierce, Flint [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Tencer, John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Pautz, Shawn D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Drumm, Clifton R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2017-09-01

This milestone campaign was focused on coupling Sandia physics codes SIERRA low Mach module Fuego and RAMSES Boltzmann transport code Sceptre(Scefire). Fuego enables simulation of low Mach, turbulent, reacting, particle laden flows on unstructured meshes using CVFEM for abnormal thermal environments throughout SNL and the larger national security community. Sceptre provides simulation for photon, neutron, and charged particle transport on unstructured meshes using Discontinuous Galerkin for radiation effects calculations at SNL and elsewhere. Coupling these ”best of breed” codes enables efficient modeling of thermal/fluid environments with radiation transport, including fires (pool, propellant, composite) as well as those with directed radiant fluxes. We seek to improve the experience of Fuego users who require radiation transport capabilities in two ways. The first is performance. We achieve this through leveraging additional computational resources for Scefire, reducing calculation times while leaving unaffected resources for fluid physics. This approach is new to Fuego, which previously utilized the same resources for both fluid and radiation solutions. The second improvement enables new radiation capabilities, including spectral (banded) radiation, beam boundary sources, and alternate radiation solvers (i.e. Pn). This summary provides an overview of these achievements.

A new modification of summary-based analysis method for large software system testing

Directory of Open Access Journals (Sweden)

A. V. Sidorin

2015-01-01

Full Text Available The automated testing tools becoming a frequent practice require thorough computer-aided testing of large software systems, including system inter-component interfaces. To achieve a good coverage, one should overcome scalability problems of different methods of analysis. These problems arise from impossibility to analyze all the execution paths. The objective of this research is to build a method for inter-procedural analysis, which efficiency enables us to analyse large software systems (such as Android OS codebase as a whole for a reasonable time (no more than 4 hours. This article reviews existing methods of software analysis to detect their potential defects. It focuses on the symbolic execution method since it is widely used both in static analysis of source code and in hybrid analysis of object files and intermediate representation (concolic testing. The method of symbolic execution involves separation of a set of input data values into equivalence classes while choosing an execution path. The paper also considers advantages of this method and its shortcomings. One of the main scalability problems is related to inter-procedural analysis. Analysis time grows rapidly if an inlining method is used for inter-procedural analysis. So this work proposes a summary-based analysis method to solve scalability problems. Clang Static Analyzer, an open source static analyzer (a part of the LLVM project, has been chosen as a target system. It allows us to compare performance of inlining and summary-based inter-procedural analysis. A mathematical model for preliminary estimations is described in order to identify possible factors of performance improvement.

Executive Remuneration and the Financial Performance of Quoted Firms: The Nigerian Experience

Directory of Open Access Journals (Sweden)

Sunday OGBEIDE

2016-12-01

Full Text Available This study examined executive remuneration and firms’ performance in Nigeria. Specifically, the study seeks to ascertain the nexus between executive remuneration, firm size and board size variables and the performance of quoted companies. The population of the study consists of all the quoted firms as at 31st December, 2014. A sample of sixty (60 companies excluding non- financial firms was selected for the period 2013 and 2014. Summary statistics such as descriptive, correlation and granger causality tests were used. Inferential statistics, using panel Generalized Least Square (EGLS with fixed effect was used for the purpose of empirical validations. This was after the application of diagnostic test to enhance the study. The study ascertained that executive remuneration has a relationship with firm performance, but negatively impacted on it; though was not statistically significant. Firm size was ascertained not to have significant positive relationship with firms’ performance; though it has a causality relationship with the performance of the firms. Board size was found to negatively affect the performance of firms and is statistically not significant. Premised on this, the study suggests that executive remuneration of quote firms should be pegged constantly in a flexible manner. This will enable shareholders known the causality relationship between what is paid to the executive and how that influence performance.

Eleventh annual U.S. DOE low-level radioactive waste management conference: Executive summary, opening plenary, technical session summaries, and attendees

Energy Technology Data Exchange (ETDEWEB)

NONE

1990-01-01

The conference consisted of ten technical sessions, with three sessions running simultaneously each day. Session topics included: regulatory updates; performance assessment;understanding remedial action efforts; low-level waste strategy and planning (Nuclear Energy); low-level waste strategy and planning (Defense); compliance monitoring; decontamination and decommissioning; waste characterization; waste reduction and minimization; and prototype licensing application workshop. Summaries are presented for each of these sessions.

Federal Facility Compliance Act, Proposed Site Treatment Plan: Background Volume. Executive Summary

International Nuclear Information System (INIS)

1995-01-01

This Federal Facility Compliance Act Site Treatment Plan discusses the options of radioactive waste management for Ames Laboratory. This is the background volume which discusses: site history and mission; framework for developing site treatment plans; proposed plan organization and related activities; characterization of mixed waste and waste minimization; low level mixed waste streams and the proposed treatment approach; future generation of TRU and mixed wastes; the adequacy of mixed waste storage facilities; and a summary of the overall DOE activity in the area of disposal of mixed waste treatment residuals

HRS Clinical Document Development Methodology Manual and Policies: Executive summary.

Science.gov (United States)

Indik, Julia H; Patton, Kristen K; Beardsall, Marianne; Chen-Scarabelli, Carol A; Cohen, Mitchell I; Dickfeld, Timm-Michael L; Haines, David E; Helm, Robert H; Krishnan, Kousik; Nielsen, Jens Cosedis; Rickard, John; Sapp, John L; Chung, Mina

2017-10-01

The Heart Rhythm Society (HRS) has been developing clinical practice documents in collaboration and partnership with other professional medical societies since 1996. The HRS formed a Scientific and Clinical Documents Committee (SCDC) with the sole purpose of managing the development of these documents from conception through publication. The SCDC oversees the process for developing clinical practice documents, with input and approval from the HRS Executive Committee and the Board of Trustees. As of May 2017, the HRS has produced more than 80 publications with other professional organizations. This process manual is produced to publicly and transparently declare the standards by which the HRS develops clinical practice documents, which include clinical practice guidelines, expert consensus statements, scientific statements, clinical competency statements, task force policy statements, and proceedings statements. The foundation for this process is informed by the Institute of Medicine's standards for developing trustworthy clinical practice guidelines; the new criteria from the National Guidelines Clearinghouse, effective June 2014; SCDC member discussions; and a review of guideline policies and methodologies used by other professional organizations. Copyright © 2017 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

Summary of the Hanford Site Environmental Report for Calendar Year 2009

Energy Technology Data Exchange (ETDEWEB)

Duncan, Joanne P.; Poston, Ted M.; Dirkes, Roger L.

2010-09-30

This summary booklet summarizes the "Hanford Site Environmental Report for Calendar Year 2009." The Hanford Site environmental report, published annually since 1958, includes information and summary data that provide an overview of activities at the U.S. Department of Energy's (DOE) Hanford Site. The Hanford Site environmental report provides an overview of activities at the site; demonstrates the status of the site’s compliance with applicable federal, state, and local environmental laws and regulations, executive orders, and DOE policies and directives; and summarizes environmental data that characterize Hanford Site environmental management performance. The report also highlights significant environmental and public protection programs and efforts. Some historical and early 2010 information is included where appropriate.

Summary of the Hanford Site Environmental Report for Calendar Year 2008

International Nuclear Information System (INIS)

Duncan, Joanne P.; Poston, Ted M.; Dirkes, Roger L.

2009-01-01

This summary booklet summarizes the 'Hanford Site Environmental Report for Calendar Year 2008'. The Hanford Site environmental report, published annually since 1958, includes information and summary data that provide an overview of activities at the U.S. Department of Energy's (DOE) Hanford Site. The Hanford Site environmental report provides an overview of activities at the site; demonstrates the status of the site's compliance with applicable federal, state, and local environmental laws and regulations, executive orders, and DOE policies and directives; and summarizes environmental data that characterize Hanford Site environmental management performance. The report also highlights significant environmental and public protection programs and efforts. Some historical and early 2009 information is included where appropriate.

Occupational exposure to ionising radiation 1990-1996. Analysis of doses reported to the Health and Safety Executive's Central Index of Dose Information

International Nuclear Information System (INIS)

1998-01-01

The Central Index of Dose Information (CIDI) is the Health and Safety Executive's (HSE's) national database of occupational exposure to ionising radiation. It is operated under contract by the National Radiological Protection Board (NRPB). CIDI receives annually, from Approved Dosimetry Services (ADS) summaries of radiation doses recorded for employees designated as classified persons in the United Kingdom. This is the second analysis of dose summary information to be published. (author)

Impact of geothermal development on the state of Hawaii. Executive summary. Volume 7

Energy Technology Data Exchange (ETDEWEB)

Siegel, B.Z.

1980-06-01

Questions regarding the sociological, legal, environmental, and geological concerns associated with the development of geothermal resources in the Hawaiian Islands are addressed in this summary report. Major social changes, environmental degradation, legal and economic constraints, seismicity, subsidence, changes in volcanic activity, accidents, and ground water contamination are not major problems with the present state of development, however, the present single well does not provide sufficient data for extrapolation. (ACR)

Identification and management of cardiometabolic risk in Canada: a position paper by the cardiometabolic risk working group (executive summary).

Science.gov (United States)

Leiter, Lawrence A; Fitchett, David H; Gilbert, Richard E; Gupta, Milan; Mancini, G B John; McFarlane, Philip A; Ross, Robert; Teoh, Hwee; Verma, Subodh; Anand, Sonia; Camelon, Kathryn; Chow, Chi-Ming; Cox, Jafna L; Després, Jean-Pierre; Genest, Jacques; Harris, Stewart B; Lau, David C W; Lewanczuk, Richard; Liu, Peter P; Lonn, Eva M; McPherson, Ruth; Poirier, Paul; Qaadri, Shafiq; Rabasa-Lhoret, Rémi; Rabkin, Simon W; Sharma, Arya M; Steele, Andrew W; Stone, James A; Tardif, Jean-Claude; Tobe, Sheldon; Ur, Ehud

2011-01-01

With the objectives of clarifying the concepts related to "cardiometabolic risk," "metabolic syndrome" and "risk stratification" and presenting practical strategies to identify and reduce cardiovascular risk in multiethnic patient populations, the Cardiometabolic Working Group presents an executive summary of a detailed analysis and position paper that offers a comprehensive and consolidated approach to the identification and management of cardiometabolic risk. The above concepts overlap and relate to the atherogenic process and development of type 2 diabetes. However, there is confusion about what these terms mean and how they can best be used to improve our understanding of cardiovascular disease treatment and prevention. The concepts related to cardiometabolic risk, pathophysiology, and strategies for identification and management (including health behaviours, pharmacotherapy, and surgery) in the multiethnic Canadian population are presented. "Global cardiometabolic risk" is proposed as an umbrella term for a comprehensive list of existing and emerging factors that predict cardiovascular disease and/or type 2 diabetes. Health behaviour interventions (weight loss, physical activity, diet, smoking cessation) in people identified at high cardiometabolic risk are of critical importance given the emerging crisis of obesity and the consequent epidemic of type 2 diabetes. Vascular protective measures (health behaviours for all patients and pharmacotherapy in appropriate patients) are essential to reduce cardiometabolic risk, and there is growing consensus that a multidisciplinary approach is needed to adequately address cardiometabolic risk factors. Health care professionals must also consider ethnicity-related risk factors in order to appropriately evaluate all individuals in their diverse patient populations. Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Summary of third international executive conference on photovoltaic power systems

Energy Technology Data Exchange (ETDEWEB)

Gillett, W.

2001-07-01

In December 1990, the International Energy Agency (IEA) invited photovoltaic manufacturers, electrical utilities, and government leaders to a groundbreaking First Congress of Executives conference in Taormina, Italy. The purpose was to develop a strategic approach to PV market development. The Taormina Congress focused on the diffusion of applications based on cost-effectiveness. A second IEA International Conference was held in Sun Valley, Idaho, in September 1995, focusing on the implementation of physical markets based on profit opportunities. Discussions in Sun Valley included the integration of utility and PV businesses into new partnerships in the developing world. By 1995, the strategic interaction of utility activity with photovoltaic technology was recognised and a number of new business opportunities were identified in both industrialised and developing countries. The November 1999 conference, held in Venice, Italy, has taken things a step further. It focused on communicating the 'value of the sun', as well as bringing in the developing business interests and expanding roles of the building construction industries and finance institutions. This theme was considered as being the most important issue of the conference and led to the conclusion that just selling kilowatt-hours is not enough, as the market needs complete products and better concepts. Further, all of the relevant stakeholders, including PV industry, project developers, architects, local, regional and national governments, and the IEA should collaborate in a world-wide effort to accelerate the growth of markets for photovoltaic electricity. The conference was designed to provide a unique forum for senior executives from the energy and building sectors, the photovoltaic industry, financial institutions and governments. The aim was to discuss and jointly develop strategic business opportunities for photovoltaics in a rapidly changing energy market and to take the growing movement

Summary of main points

International Nuclear Information System (INIS)

2006-01-01

In conjunction with its 6. annual meeting, the WPDD in close co-operation with the FSC held a Topical session on 'Stakeholder Involvement in Decommissioning' on November 14, 2005. The session was attended by 36 participants totally representing 14 NEA member countries and 2 international organisations. Two keynote addresses were given at the Topical Session. The first one treated of what is needed for robust decisions and how to bring all stakeholders into the debate. In the second keynote address a summary was made on what have been said on stakeholder involvement in decommissioning during earlier meetings of the WPDD. The main part of the session was then devoted to views from different stakeholders regarding their role and their involvement. This part contained viewpoints from local communities (Kaevlinge in Sweden and Port Hope in Canada), authorities (Scottish Executive and CSNC) and operators (EDF from France and EWN from Germany). Case studies from the decommissioning of Dounrey in the UK and from Trojan and Main Yankee in the USA were presented in the end part of the Topical session followed by a summary and lessons learnt report by the Rapporteur. A detailed programme of the Topical session can be seen in Appendix 1

Effective Classroom Management and Instruction: An Exploration of Models. Executive Summary of Final Report.

Science.gov (United States)

Evertson, Carolyn M.; And Others

A summary is presented of the final report, "Effective Classroom Management and Instruction: An Exploration of Models." The final report presents a set of linked investigations of the effects of training teachers in effective classroom management practices in a series of school-based workshops. Four purposes were addressed by the study: (1) to…

Analysis of doses reported to the Health and Safety Executive's Central Index of Dose Information

International Nuclear Information System (INIS)

1993-01-01

This publication analyses the occupational exposure summary information reported to the UK Health and Safety Executive for the years 1986-91. In particular, it considers evidence pointing to the relative success of employers in restricting occupational exposure to ionising radiation over this period. Exposure in the nuclear industry, industrial radiography, non-coal miners underground, medicine, dentistry and the transport sector is discussed. (UK)

超声乳化-原位聚合法制备薄荷脑微胶囊%Preparation of Microcapsules Containing Menthol by Ultrasonic Emulsification and In-situ Polymerization

Institute of Scientific and Technical Information of China (English)

施云舟; 王彪; 朱方亮

2013-01-01

Microcapsules containing menthol were prepared by ultrasonic emulsification and in-situ polymerization. Effects of polymerization condition on morphology, structure, particle size and the distribution of the microcapsules were studied. Scanning electronic microscopy (SEM), optical microscopy (OM), Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimeter (DSC), thermogravimetric analysis (TGA), laser particle size measurement were used for characterization. The results revealed that the release of menthol was effectively delayed because of the protection of wall material,; uniform particle size and good dispersion could be achieved by adjusting poly-condensation reaction time, the content of menthol, and the temperature; the increase of the emulsifier concentration or the ultrasonic power within a certain range contributed to reducing the diameter and improving the dispersion of microcapsules.%采用原位聚合法,结合超声乳化工艺,制备以薄荷脑为囊芯的微胶囊,并研究了反应条件对微胶囊形貌和粒径的影响.利用扫描电镜(SEM)、光学显微镜(OM)、傅里叶红外光谱(FT-IR)、差示扫描量热仪(DSC)、热重分析(TGA)、激光粒度测试等手段对薄荷脑微胶囊进行了结构和性能的表征.结果表明:所制得的薄荷脑微胶囊包覆良好,能够有效延缓薄荷脑的挥发和逸散；通过调节缩聚反应时间、薄荷脑添加量、反应温度可以得到粒径较为均一、分散性良好的微胶囊；在一定范围内,可以通过提高乳化剂质量浓度和超声功率来减小微胶囊粒径及其分布区间.

Proceedings of the ninth annual DOE low-level waste management forum: executive summary, technical and special session summaries, attendees

International Nuclear Information System (INIS)

Anon.

1988-01-01

This first volume of proceedings contains summaries of each of six technical sessions as well as three special sessions held during the conference. The six technical sessions were: Disposal technology and facility development (15 papers); Institutional and regulatory issues (10); Performance assessment (14); Waste characterization and verification (7); Site closure and stabilization (6); and Waste treatment (8). The three special sessions were: 1) Review of criteria for guidance on alternative disposal technology; 2) Hazardous waste regulatory update; and 3) Challenges to meeting the 1993 deadline. All papers have been indexed for inclusion on the Energy Data Base

Production development and utilization of Zimmer Station wet FGD by-products. Final report. Volume 1, Executive summary

Energy Technology Data Exchange (ETDEWEB)

Smith, Kevin [Dravo Technology Center, Pittsburgh, PA (United States); Beeghly, Joel H. [Dravo Technology Center, Pittsburgh, PA (United States)

2000-11-30

About 30 electric utility units with a combined total of 15,000 MW utilize magnesium enhanced lime flue gas desulfurization (FGD) systems. A disadvantage of this and other inhibited or natural oxidation wet FGD systems is the capital and operating cost associated with landfill disposal of the calcium sulfite based solids. Fixation to stabilize the solids for compaction in a landfill also consumes fly ash that otherwise may be marketable. This Executive Summary describes efforts to dewater the magnesium hydroxide and gypsum slurries and then process the solids into a more user friendly and higher value form. To eliminate the cost of solids disposal in its first generation Thiosorbic® system, the Dravo Lime Company developed the ThioClear® process that utilizes a magnesium based absorber liquor to remove S0₂ with minimal suspended solids. Magnesium enhanced lime is added to an oxidized bleed stream of thickener overflow (TOF) to produce magnesium hydroxide [Mg(OH)₂] and gypsum (CaS0₄ • 2H₂0), as by-products. This process was demonstrated at the 3 to 5 MW closed loop FGD system pilot plant at the Miami Fort Station of Cinergy, near Cincinnati, Ohio with the help of OCDO Grant Agreement CDO/D-91-6. A similar process strictly for'recovery and reuse of Mg(OH)₂ began operation at the Zimmer Station of Cinergy in late 1994 that can produce 900 pounds of Mg(OH)₂ per hour and 2,600 pounds of gypsum per hour. This by-product plant, called the Zimmer Slipstream Magnesium Hydroxide Recovery Project Demonstration, was conducted with the help of OCDO Grant Agreement CDO/D-921-004. Full scale ThioClear® plants began operating in 1997 at the 130 MW Applied Energy Services plant, in Monaca, PA, and in year 2000 at the 1,330 MW Allegheny Energy Pleasants Station at St. Marys, WV.

Executive summary 2000

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-07-01

Blue Energy Canada is a company that focuses on ocean energy technology. Considered the world's most advanced such technology, it involves high-density seawater passing through advanced vertical axis hydro turbines that are used to convert the kinetic energy in ocean currents, tides and rivers to low-cost electric power. A ten-year collaboration effort with the National Research Council of Canada (NRC) led to the development of the successful prototypes. A privately funded prototype was successfully implemented which generated power from the Florida Gulf Stream. The NRC, as well as independent engineering assessments have proven that the technology is sound and ready for the next phase: commercialization. This low-cost technology compares favorably with hydro, thermal nuclear, and wind energy. Once fuel and maintenance costs are included, micro units will be cost competitive with diesel generators. The high density of the system is approximately 180 times greater than that of wind and solar technologies. Its environmental impact is minimal, generating no pollution or emitting no greenhouse gases, and does not affect the flow of silt, fish and aquatic life. Marine fences will be erected to protect marine mammals from the turbines, coupled with a backup auto-braking system controlled by sonar sensors. It is possible to reliably predict the energy output based on the cyclical tidal patterns. The design is modular, allowing for the production of power as soon as the first turbine is installed. The addition of turbines will provide incremental capacity. The multiple infrastructure design allows the structure to be used to carry water mains, fiber optics, power lines and phone lines, thereby sharing construction costs. The technology ensures a low maintenance since generator and gearbox are both located above water level, eliminating the requirement for seals and the associated risks. The commercialization plan was detailed, with phase I projected for the implementation of a 500 kW demonstration project off the coast of British Columbia. The implementation of phase II involves utilizing the technology developed by Blue Energy to electrolyse clean hydrogen to fuel a 250 kW stationary hydrogen fuel cell. The manufacturing process uses an automated assembly line, and the cost is competitive with other distributed power systems. Large scale power projects are being developed, with the focus placed on Taiwan, the Philippines, the United Kingdom and the United States in 2005. The funding was briefly discussed and the use of proceeds detailed. 1 fig.

SCIL Executive Summaries.

Science.gov (United States)

Samuels, Alan R.; And Others

1987-01-01

These five papers by speakers at the Small Computers in Libraries 1987 conference include: "Acquiring and Using Shareware in Building Small Scale Automated Information systems" (Samuels); "A Software Lending Collection" (Talab); "Providing Subject Access to Microcomputer Software" (Mitchell); "Interfacing Vendor…

Preliminaries & Executive Summary

International Development Research Centre (IDRC) Digital Library (Canada)

jg

2007-05-29

May 29, 2007 ... and government officials struggling with designing an appropriate policy and/or ..... of production, such as labour, supporting them while they re-tool. ...... manufacturers of polythene pipes engaged in bid rigging claimed that ...

Tutoring executives online

DEFF Research Database (Denmark)

Bignoux, Stephane; Sund, Kristian J.

2018-01-01

Studies of learning and student satisfaction in the context of online university programmes have largely neglected programmes catering specifically to business executives. Such executives have typically been away from higher education for a number of years, and have collected substantial practical...... experience in the subject matters they are taught. Their expectations in terms of both content and delivery may therefore be different from non-executive students. We explore perceptions of the quality of tutoring in the context of an online executive MBA programme through participant interviews. We find...... that in addition to some of the tutor behaviours already discussed in the literature, executive students look specifically for practical industry knowledge and experience in tutors, when judging how effective a tutor is. This has implications for both the recruitment and training of online executive MBA tutors....

Tutoring Executives Online

DEFF Research Database (Denmark)

Bignoux, Stephane; Sund, Kristian J.

2016-01-01

Studies of learning and student satisfaction in the context of online university programs have largely neglected programs catering specifically to business executives. Such executives have typically been away from higher education for a number of years, and have collected substantial practical...... experience in the subject matters they are taught. Their expectations in terms of both content and delivery may therefore be different from non-executive students. We explore perceptions of the quality of tutoring in the context of an online executive MBA program through participant interviews. We find...... that in addition to some of the tutor behaviors already discussed in the literature, executive students look specifically for practical industry knowledge and experience in tutors, when judging how effective a tutor is. This has implications for both the recruitment and training of online executive MBA tutors....

Summary of TMX results: executive summary

International Nuclear Information System (INIS)

Simonen, T.C.

1981-01-01

This report summarizes results from the successful experimental operation of the Tandem Mirror Experiment (TMX) over the period October 1978 through September 1980. The experimental program, summarized by the DOE milestones given in Table 1, had three basic phases: (1) an 8-month checkout period, October 1978 through May 1979; (2) a 6-month initial period of operation, June through November 1979, during which the basic principles of the tandem configuration were demonstrated (i.e., plasma confinement was improved over that of a single-cell mirror); and (3) a 10-month period, December 1979 through September 1980, during which the initial TMX results were corroborated by additional diagnostic measurements and many detailed physics investigations were carried out. This report summarizes the early results, presents results of recent data analysis, and outlines areas of ongoing research

Eficácia do mentol como anestésico para juvenis de tilápia-do-nilo (Oreochromis niloticus Menthol efficiency as anesthetic for juveniles Nile tilapia Oreochromis niloticus

Directory of Open Access Journals (Sweden)

L.N. Simões

2009-06-01

Full Text Available Em três experimentos, testou-se a eficiência do mentol como anestésico para a tilápia-do-nilo (Oreochromis niloticus, por meio da avaliação de eventos comportamentais, da verificação da margem de segurança do anestésico e das respostas de estresse. No primeiro experimento, foram testadas seis diferentes concentrações de mentol para avaliar o tempo de indução à anestesia. No segundo, foram realizados dois testes com o objetivo de verificar a margem de segurança do anestésico. No terceiro, avaliou-se o efeito estressante do anestésico. A concentração 250mg L-1 de mentol foi a mais adequada para indução de anestesia cirúrgica. Para anestesia voltada para biometria e breve inspeção visual do animal, a concentração mais adequada foi 150-200mg L-1. O dobro da concentração ideal (500mg L-1 não acarretou a morte nos indivíduos, indicando boa margem de segurança para o uso desse anestésico. O mentol, mesmo em sua concentração adequada, induziu ao aumento na glicose sanguínea, caracterizando estresse no peixe. Conclui-se que o mentol não é um anestésico eficaz para juvenis de tilápia durante procedimentos de rotina na piscicultura.This work tested the effectiveness of menthol as anesthetic for Nile tilápia (Oreochromis niloticus by the evaluation of behavioral events, the safety margin of the anesthetic, and stress response. On first experiment, six different anesthetic concentrations were tested to evaluate the induction time to anesthesia. On second experiment, two tests were carried out to verify the safety margin of the anesthetic. On third experiment, stress responses were evaluated. The safe concentration to induce a surgical anesthesia was 250mg L-1. To a brief handling and visual inspection, the appropriated concentration was 150-200mg L-1. There was no mortality after exposure to 500mg L-1, indicating a good safety margin for this anesthetic. Menthol even in its adequate dosage induced a rise in glucose

Trends in public perceptions and preferences on energy and environmental policy: Executive summary

Energy Technology Data Exchange (ETDEWEB)

Farhar, B.C.

1993-03-01

This is a summary of a report that presents selected results from a secondary analysis of public opinion surveys, taken at the national and state/local levels, relevant to energy and environmental policy choices. The data base used in the analysis includes about 2,000 items from nearly 600 separate surveys conducted between 1979 and 1992. Answers to word-for-word questions were traced over time, permitting trend analysis. Patterns of response were also identified for findings from similarly worded survey items. The analysis identifies changes in public opinion concerning energy during the past 10 to 15 years.

Physical protection of special nuclear material in the commercial fuel cycle. Volume I. Executive summary

International Nuclear Information System (INIS)

1976-04-01

This is the summary of the work and recommendations resulting from Sandia's participation in the Special Safeguards Study, which covered three areas: protection of SNM at fixed facilities, protection of SNM while in transit, and relocation and recovery of lost SNM. The results are published in full in five other volumes. 6 tables, 4 fig

Preserving heritage resources through responsible use of southern Nevada’s lands [Chapter 9] (Executive Summary)

Science.gov (United States)

Carol B. Raish

2013-01-01

Southern Nevada’s cultural resources (heritage resources) include archeological remains, sacred sites, historic sites, and cultural landscapes of significance to Native Americans and many other cultural groups. Locating, maintaining, and protecting these special places are part of the mandate of Nevada’s Federal and state agencies. This summary addresses Sub-goal 2.2...

Pre-feasibility workbook for bioenergy projects in eastern Ontario : executive summary

International Nuclear Information System (INIS)

Rees, C.; Bradley, D.; DeYoe, D.

2007-03-01

This summary provided details of a pre-feasibility workbook designed to assist communities and developers in better understanding bioenergy challenges and opportunities in Ontario. The workbook examined issues related to the conversion of biomass through thermal conversion technologies and focused on combined heat and power projects that used forest and agricultural biomass in order to produce up to 10 MW of electricity under the Ontario Renewable Standard Offer Program. As part of the program, new generators of no more than 10 MW are paid a base rate of 11 cents per kWh and an additional 3.52 cents per kWh for on-peak production. The workbook was comprised of a review of biomass supply in the eastern Ontario region and included both forested and abandoned farm lands. A base-line financial analysis was included to assess the feasibility of projects using combustion, pyrolysis, and gasification technologies. Biomass sources in the region included mill residue, harvest waste, biomass mortality from natural events, stand management, and standing timber. Key elements required for parties interested in considering a bioenergy business initiative were also included

Executive Summary of Ares V: Lunar Capabilities Concept Review Through Phase A-Cycle 3

Science.gov (United States)

Holladay, J. B.; Baggett, K. E.; Feldman, S. M.

2011-01-01

This Technical Memorandum (TM) was generated as an overall Ares V summary from the Lunar Capabilities Concept Review (LCCR) through Phase A-Cycle 3 (PA-C3) with the intent that it may be coupled with separately published appendices for a more detailed, integrated narrative. The Ares V has evolved from the initial point of departure (POD) 51.00.48 LCCR configuration to the current candidate POD, PA-C3D, and the family of vehicles concept that contains vehicles PA-C3A through H. The logical progression from concept to POD vehicles is summarized in this TM and captures the trade space and performance of each. The family-of-vehicles concept was assessed during PA-C3 and offered flexibility in the path forward with the ability to add options deemed appropriate. A description of each trade space is given in addition to a summary of each Ares V element. The Ares V contributions to a Mars campaign are also highlighted with the goal of introducing Ares V capabilities within the trade space. The assessment of the Ares V vehicle as it pertains to Mars missions remained locked to the architecture presented in Mars Design Reference Authorization 5.0 using the PA-C3D vehicle configuration to assess Mars transfer vehicle options, in-space EDS capabilities, docking adaptor and propellant transfer assessments, and lunar and Mars synergistic potential.

Environmental assessment of exploration drilling off Nova Scotia: executive summary

International Nuclear Information System (INIS)

2000-01-01

The environmental assessment project of drilling offshore Nova Scotia covers year-around drilling conducted from jackup rigs, semi-submersible rigs, and drill ships that use the methods described in the project description on the Scotian Shelf, the Laurentian Channel and St, Pierre Bank. The assessment was sponsored by all the oil companies active in the area, namely Mobil Oil Canada, Shell Canada, Imperial Oil Resources, Gulf Canada Resources, Chevron Canada Resources, PanCanadian Petroleum, Murphy Oil Company and Norsk Hydro Canada Oil and Gas. This summary describes the impact assessment methodology used, provides a description of the project, reviews the cumulative impact, and the impacts of discrete activities such as noise and disturbances, operational discharges of oil, disruption of the benthos, garbage and waste disposal, and accidental oil spills, and outlines mitigation and monitoring activities to deal with the impacts. Mitigation measures encompass routine discharges, accidental oil spills, spill response, monitoring activities, contingency plans and an overall environmental protection plan. In addition to this generic assessment, the consultants recommend that individual exploration drilling programs that fall outside of the parameters outlined in the generic environmental assessment document, be required to undergo a program-specific assessment that focuses on those aspects of the proposed program that differ from the parameters prescribed in the present document. 9 refs

Executive summary and recommendations from WHO/UNAIDS and AAVP consultation on: 'The inclusion of adolescents in HIV vaccine trials', 16-18 March 2006 in Gaborone, Botswana.

Science.gov (United States)

Osmanov, Saladin

2007-09-12

This report summarizes the discussions and recommendations from a consultation held in Gaborone, Botswana (16-19 March 2006), organized by the joint World Health Organization (WHO)/United Nations Programme on HIV/AIDS (UNAIDS) HIV Vaccine Initiative (HVI) and the African AIDS Vaccine Programme (AAVP). The consultation considered key challenges and strategies in enrolling adolescents into HIV vaccine clinical trials, relevant to developing countries, in particular in eastern and southern Africa. Approaches were identified that might address and resolve country-specific challenges related to scientific, legal, ethical, regulatory and community aspects of the involvement of adolescents in HIV vaccine trials. This executive summary is formulated for a broader dissemination of the outcomes of the meeting to the general clinical, scientific and regulatory community involved in the review, approval and monitoring of clinical trials and potential licensing of HIV vaccine candidates. Four major topics were discussed and recommendations developed with regard to: (i) criteria for products selection and clinical trial design; (ii) ethical and legal issues; (iii) community acceptance and participation; and (iv) regulatory considerations. The recommendations of this meeting were further discussed and endorsed by the WHO/UNAIDS HIV Vaccine Advisory Committee.

Acute effects of exercise posture on executive function in transient ischemic attack patients.

Science.gov (United States)

Faulkner, James; Stoner, Lee; Grigg, Rebecca; Fryer, Simon; Stone, Keeron; Lambrick, Danielle

2017-08-01

In patients with stroke or transient ischemic attacks (TIA), a decline in executive function may limit an individual's ability to process motor tasks and relearn motor skills. The purpose of this study was to assess the acute effect of exercise posture (seated vs. supine cycle ergometry) on executive function and prefrontal cortex perfusion in patients with TIA. Eleven TIA patients (65 ± 10 years) and 15 age-matched, healthy controls (HC; 62 ± 7 years) completed two exercise tests to maximal capacity (one seated, one supine) and two 30-min submaximal exercise tests (one seated, one supine). Executive function was assessed prior to and following (1.5 min post, 15 min post) the submaximal exercise tests using a Stroop task. Prefrontal cortex perfusion (total hemoglobin) was continuously recorded using near-infrared spectroscopy. There was no Posture (seated, supine) × Group (TIA, HC) interaction for the Stroop task (p > .05). HC completed Stroop tasks significantly faster than TIA (51.9[SD = 10.3] vs. 64.2[8.5] s, respectively), while Stroop completion time significantly improved between baseline and 1.5 min post (61.3[10] vs. 58.1[9.4] s, respectively) and 1.5 min post and 15 min post (54.8[8.9] s). Posture and group had no significant influence on prefrontal cortex perfusion (p > .05). In summary, executive function improves to a similar extent in TIA and age-matched, healthy controls following an acute bout of exercise, regardless of exercise posture. As acute improvements in executive function were maintained for 15 min, there could be an important window of opportunity for assigning executive tasks following exercise rehabilitation for patients with TIA. © 2017 Society for Psychophysiological Research.

Summaries of FY 1981 research in the chemical sciences

International Nuclear Information System (INIS)

1981-08-01

The purpose of this booklet is to help those interested in research supported by the Department of Energy's Division of Chemical Sciences, which is one of six Divisions of the Office of Basic Energy Sciences in the Office of Energy Research. Chemists, physicists, chemical engineers and others who are considering the possibility of proposing research for support by this Division will find the booklet useful for gauging the scope of the program in basic research, and the relationship of their interests to the overall program. These summaries are intended to provide a rapid means for becoming acquainted with the Chemical Sciences program to members of the scientific and technological public and interested persons in the Legislative and Executive Branches of the Government. Areas of research supported by the Division are to be seen in the section headings, the index and the summaries themselves. Energy technologies which may be advanced by use of the basic knowledge discovered in this program can be seen in the index and again (by reference) in the summaries. The contents are as follows: DOE laboratires; chemical physics; atomic physics; chemical energy; separations; analysis; chemical engineering sciences; offsite contracts; equipment funds; topical index; institutional index for offsite contracts; and investigator index

Tabled Execution in Scheme

Energy Technology Data Exchange (ETDEWEB)

Willcock, J J; Lumsdaine, A; Quinlan, D J

2008-08-19

Tabled execution is a generalization of memorization developed by the logic programming community. It not only saves results from tabled predicates, but also stores the set of currently active calls to them; tabled execution can thus provide meaningful semantics for programs that seemingly contain infinite recursions with the same arguments. In logic programming, tabled execution is used for many purposes, both for improving the efficiency of programs, and making tasks simpler and more direct to express than with normal logic programs. However, tabled execution is only infrequently applied in mainstream functional languages such as Scheme. We demonstrate an elegant implementation of tabled execution in Scheme, using a mix of continuation-passing style and mutable data. We also show the use of tabled execution in Scheme for a problem in formal language and automata theory, demonstrating that tabled execution can be a valuable tool for Scheme users.

The Herbivore-Induced Plant Volatiles Methyl Salicylate and Menthol Positively affect Growth and Pathogenicity of Entomopathogenic Fungi

Science.gov (United States)

Lin, Yongwen; Qasim, Muhammad; Hussain, Mubasher; Akutse, Komivi Senyo; Avery, Pasco Bruce; Dash, Chandra Kanta; Wang, Liande

2017-01-01

Some herbivore-induced-plant volatiles (HIPVs) compounds are vital for the functioning of an ecosystem, by triggering multi-trophic interactions for natural enemies, plants and herbivores. However, the effect of these chemicals, which play a crucial role in regulating the multi-trophic interactions between plant-herbivore-entomopathogenic fungi, is still unknown. To fill this scientific gap, we therefore investigated how these chemicals influence the entomopathogenic fungi growth and efficacy. In this study, Lipaphis erysimi induced Arabidopsis thaliana HIPVs were collected using headspace system and detected with GC-MS, and then analyzed the effects of these HIPVs chemicals on Lecanicillium lecanii strain V3450. We found that the HIPVs menthol and methyl salicylate at 1 and 10 nmol·ml-1 improved many performance aspects of the fungus, such as germination, sporulation, appressorial formation as well as its pathogenicity and virulence. These findings are not only important for understanding the multi-trophic interactions in an ecosystem, but also would contribute for developing new and easier procedures for conidial mass production as well as improve the pathogenicity and virulence of entomopathogenic fungi in biological pest management strategies.

Final summary report of the Nordic Nuclear Safety Research Program 1998-2001

International Nuclear Information System (INIS)

Bennerstedt, T.

2002-11-01

The results of the 1998 - 2001 NKS program are presented in the form of executive summaries, highlighting the conclusions, recommendations and other findings and results of the six projects carried out during that period. The titles of the six projects are: Risk assessment and strategies for safety (NKS/SOS-1); Reactor safety (NKS/SOS-2); Radioactive waste (NKS/SOS-3); Nuclear Emergency preparedness (NKS/BOK-1); Radiological and environmental consequences (NKS/BOK-2); Nuclear threats from Nordic surroundings (NKS/SBA-1) (ln)

Oral hygiene grade and quality of life in children with chemotherapy-related oral mucositis: a randomized study on the impact of a fluoride toothpaste with salivary enzymes, essential oils, proteins and colostrum extract versus a fluoride toothpaste without menthol.

Science.gov (United States)

Bardellini, E; Amadori, F; Majorana, A

2016-11-01

The aim of this study was to assess the impact of the use of a fluoride toothpaste (Bioxtra ® , Biopharm, Milan, Italy) with salivary enzymes, essential oils, proteins and colostrum extract versus a fluoride toothpaste without menthol on the oral hygiene grade and on the quality of life (QoL) of children with oral mucositis (OM) grade 1 or 2 receiving chemotherapy for Acute Lymphoblastic Leukaemia (ALL). Patients between 6 and 14 years with OM were randomly assigned to two groups, group A (Bioxtra ® toothpaste) and group B (fluoride toothpaste without menthol). The patients were instructed to brush their teeth at least twice a day using a soft toothbrush with a small head. Oral hygiene grade was assessed using the simplified oral hygiene index (OHI-s); quality of life was assessed using the short form of the Oral Health Impact Profile (OHIP-14) questionnaires. The patients were evaluated on day 1(diagnosis of OM-T0) and on day 8 (T1). Statistical analysis was performed. A total of 64 patients were enrolled. A significant difference (P oral hygiene grade. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Executive dysfunctions in pedophilic and nonpedophilic child molesters.

Science.gov (United States)

Schiffer, Boris; Vonlaufen, Corinne

2011-07-01

There is some evidence that child molesters show neuropsychological abnormalities which might reflect specific structural and/or functional brain alterations, but there are also inconsistencies in the existing findings which need to be clarified. Most of the different outcomes can either be explained by the fact that different types of child molesters were examined or by not having accounted for basically confounding factors such as age, education/intelligence, or criminality. The present study therefore sought to determine whether pedophilic and nonpedophilic child molesters, compared to relevant control groups, show different profiles of executive dysfunction when accounting for potentially confounding factors. The performance of 30 child molesters (15 pedophilic and 15 nonpedophilic) and 33 age- and education-matched controls (16 nonsexual offenders and 17 healthy controls) was assessed regarding several neuropsychological functions. Scores on different neurocognitive tests and semistructured diagnostical interviews. Results indicate that pedophilic child molesters exhibited less performance deficits in cognitive functioning than nonpedophilic child molesters. Compared to healthy controls and nonsexual offenders, the pedophilic child molesters only showed executive dysfunction concerning response inhibition, whereas the nonpedophilic child molesters revealed more severe dysfunction, especially on tasks associated with cognitive flexibility and verbal memory. These results enhance our knowledge about executive dysfunction associated with criminality and/or pedophilia, as they suggest different profiles of impairment between groups. In summary, data suggest that nonpedophilic child molesters showed more severe cognitive deficits than pedophilic child molesters. However, as response inhibition is associated with prefrontal (i.e., orbitofrontal) functioning, the deficits observed in both child molester groups indicate dysfunction in the orbitofrontal cortex. This

FWP executive summaries, Basic Energy Sciences Materials Sciences Programs (SNL/NM)

Energy Technology Data Exchange (ETDEWEB)

Samara, G.A.

1997-05-01

The BES Materials Sciences Program has the central theme of Scientifically Tailored Materials. The major objective of this program is to combine Sandia`s expertise and capabilities in the areas of solid state sciences, advanced atomic-level diagnostics and materials synthesis and processing science to produce new classes of tailored materials as well as to enhance the properties of existing materials for US energy applications and for critical defense needs. Current core research in this program includes the physics and chemistry of ceramics synthesis and processing, the use of energetic particles for the synthesis and study of materials, tailored surfaces and interfaces for materials applications, chemical vapor deposition sciences, artificially-structured semiconductor materials science, advanced growth techniques for improved semiconductor structures, transport in unconventional solids, atomic-level science of interfacial adhesion, high-temperature superconductors, and the synthesis and processing of nano-size clusters for energy applications. In addition, the program includes the following three smaller efforts initiated in the past two years: (1) Wetting and Flow of Liquid Metals and Amorphous Ceramics at Solid Interfaces, (2) Field-Structured Anisotropic Composites, and (3) Composition-Modulated Semiconductor Structures for Photovoltaic and Optical Technologies. The latter is a joint effort with the National Renewable Energy Laboratory. Separate summaries are given of individual research areas.

Mentol e eugenol como substitutos da benzocaína na indução anestésica de juvenis de pacu - DOI: 10.4025/actascianimsci.v30i3.1081 Eugenol and menthol as benzocaine substitutes in anaesthesic induction of pacu juveniles - DOI: 10.4025/actascianimsci.v30i3.1081

Directory of Open Access Journals (Sweden)

João Batista Kochenborger Fernandes

2008-11-01

Full Text Available Objetivou-se verificar a eficiência de anestésicos naturais na indução à anestesia de juvenis de pacu. Foram avaliadas quatro concentrações de mentol (50, 100, 150 e 200 mg L-1, quatro de eugenol (10, 25, 50 e 100 mg L-1 e uma de benzocaína (100 mg L-1. Durante o procedimento de anestesia, foram monitorados e avaliados quatro estágios de sedação, da redução dos movimentos operculares até a perda total de reação à manipulação. Após o procedimento de biometria, foram avaliados o tempo de recuperação e a mortalidade até 48h após anestesia. As concentrações de 100, 150 e 200 mg L-1 de mentol e as concentrações de 50 e 100 mg L-1 de eugenol apresentaram tempos de indução à anestesia e recuperação similares aos da benzocaína. Os resultados obtidos mostraram que o mentol e o eugenol são anestésicos eficientes para pacus em substituição à benzocaína, sugerindo a concentração de 100 mg L-1 de mentol e 50 mg L-1 de eugenol.Anaesthetics represents important tool for management procedures in aquaculture. This study aimed to verify the efficacy of natural anaesthesic induction of pacu juvenile. Were evaluated four menthol concentrations (50, 100, 150 and 200 mg L-1, four eugenol (10, 25, 50 and 100 mg L-1 and one of benzocaine (100 mg L-1. During the anaesthesic procedure were monitored and evaluated four sedative stages, until no reaction to handling. After biometric was evaluated recovery time and mortality 48 hours after anaesthesia. Concentrations 100, 150 and 200 mg L-1 of menthol, 50 and 100 mg L-1 of eugenol showed anaesthesic induction time and recovery time similar of benzocaine. The obtained results showed that menthol is an efficient anaesthesic for pacu juvenile in substitution of benzocaine, suggesting the concentration of 100 mg L-1 of menthol and 50 mg L-1 of eugenol.

Definition of technology development missions for early space station, orbit transfer vehicle servicing. Volume 1: Executive summary

Science.gov (United States)

1983-01-01

Orbital Transfer Vehicle (OTV) servicing study scope, propellant transfer, storage and reliquefaction technology development missions (TDM), docking and berthing TDM, maintenance TDM, OTV/payload integration TDM, combined TDMS design, summary space station accomodations, programmatic analysis, and TDM equipment operational usage are discussed.

Rainwater Wildlife Area Management Plan Executive Summary : A Columbia Basin Wildlife Mitigation Project.

Energy Technology Data Exchange (ETDEWEB)

Childs, Allen B.

2002-02-01

This Executive Summary provides an overview of the Draft Rainwater Wildlife Area Management Plan. The comprehensive plan can be viewed on the Confederated Tribes of the Umatilla Indian Reservation (CTUIR) website at: www.umatilla.nsn.us or requested in hard copy from the CTUIR at the address below. The wildlife area was established in September 1998 when the CTUIR purchased the Rainwater Ranch through Bonneville Power Administration (BPA) for purposes of fish and wildlife mitigation for the McNary and John Day dams. The Management Plan has been developed under a standardized planning process developed by BPA for Columbia River Basin Wildlife Mitigation Projects (See Guiding Policies Section below). The plan outlines the framework for managing the project area, provides an assessment of existing conditions and key resource issues, and presents an array of habitat management and enhancement strategies. The plan culminates into a 5-Year Action Plan that will focus management actions and prioritize funding during the 2002-2006 planning period. Since acquisition of the property in late 1998, the CTUIR has conducted an extensive baseline resource assessment in preparation for the management plan, initiated habitat restoration in the Griffin Fork drainage to address road-related resource damage caused by roads constructed for forest practices and an extensive flood event in 1996, and initiated infrastructure developments associated with the Access and Travel Management Plan (i.e., installed parking areas, gates, and public information signs). In addition to these efforts, the CTUIR has worked to set up a long-term funding mechanism with BPA through the NPPC Fish and Wildlife Program. The CTUIR has also continued to coordinate closely with local and state government organizations to ensure consistency with local land use laws and maintain open lines of communication regarding important issues such as big game hunting, tribal member exercise of treaty rights, and public

Senior expert symposium on electricity and the environment, Helsinki, Finland, 13-17 May 1991. Executive summary

International Nuclear Information System (INIS)

1991-07-01

This document summarizes the key issues of the Senior Expert Symposium on Electricity and the Environment held in Helsinki, Finland in May 1991, and highlights the main findings. It is hoped that this summary will contribute to rational and objective discussion of different options and strategies aimed at ensuring the provision of adequate and economical electricity services while protecting health and the environment

5 CFR 842.211 - Senior Executive Service, Defense Intelligence Senior Executive Service, and Senior Cryptologic...

Science.gov (United States)

2010-01-01

... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Senior Executive Service, Defense Intelligence Senior Executive Service, and Senior Cryptologic Executive Service. 842.211 Section 842.211... EMPLOYEES RETIREMENT SYSTEM-BASIC ANNUITY Eligibility § 842.211 Senior Executive Service, Defense...

A Research Needs Assessment for waste plastics recycling: Volume 1, Executive summary. Final report

Energy Technology Data Exchange (ETDEWEB)

NONE

1994-12-01

This first volume provides a summary of the entire project. The study utilized the talents of a large number of participants, including a significant number of peer reviewers from industrial companies, government agencies, and research institutes. in addition, an extensive analysis of relevant literature was carried out. In considering the attractiveness of recycling technologies that are alternatives to waste-to-energy combustion units, a systems approach was utilized. Collection of waste streams containing plastics, sortation, and reclamation of plastics and plastic mixtures, reprocessing or chemical conversion of the reclaimed polymers, and the applicability of the products to specific market segments have been analyzed in the study.

Executive summary. Summary of the workshop sessions

International Nuclear Information System (INIS)

2012-01-01

The workshop played a great role in sharing the current state-of-the art on the PSA (Probabilistic Safety Assessment) of new and advanced reactors, and points of interest among member countries. The major concern expressed by the participants included passive safety system reliability, digital system reliability, new and advanced reactors-specific risk assessment methodology and relevant computational tool, and safety-security interface, etc). Main findings obtained from the workshop are as follows. For new reactors, the role of PSA is more important and more formalized comparing with exiting reactors. The PSAs are being used in the design of new reactors for purposes such as balance between accident prevention and mitigation features of the design, demonstration of safety, identification of design vulnerabilities and improvements, and comparison with the risk of existing plants, etc. For advanced reactors, the role of PSA is also being regarded as an essential tool for safety improvement and comparison of reactor designs at the conceptual or preliminary stages, but their practical use is at the early stage to gain the insights of risk into these reactors. This is due to the fact that the use of PSA for advanced reactors is mainly focused on identifying the PSA issues for designer and regulatory bodies, and developing the relevant methodologies and tools. Better guidance and peer review process on the PSA of new and advanced reactors was identified by both industry and regulatory as an important aspect

IAEA technical meeting: 13th meeting of the IFRC Subcommittee on Atomic and Molecular Data for Fusion. Summary report

International Nuclear Information System (INIS)

Clark, R.E.H.; Peacock, N.J.

2002-11-01

This report briefly describes the proceedings, conclusions and recommendations of the 13th Meeting of the Subcommittee on Atomic and Molecular Data for Fusion of the International Fusion Research Council held on 24-25 June, 2002 at the IAEA Headquarters in Vienna Austria. The report includes an Executive Summary of the Subcommittee from this Meeting. (author)

Hanford Site Environmental Safety and Health Fiscal Year 2001 Budget-Risk management summary

Energy Technology Data Exchange (ETDEWEB)

REEP, I.E.

1999-05-12

The Hanford Site Environment, Safety and Health (ES&H) Budget-Risk Management Summary report is prepared to support the annual request to sites in the U.S. Department of Energy (DOE) Complex by DOE, Headquarters. The request requires sites to provide supplementary crosscutting information related to ES&H activities and the ES&H resources that support these activities. The report includes the following: (1) A summary status of fiscal year (FY) 1999 ES&H performance and ES&H execution commitments; (2)Status and plans of Hanford Site Office of Environmental Management (EM) cleanup activities; (3) Safety and health (S&H) risk management issues and compliance vulnerabilities of FY 2001 Target Case and Below Target Case funding of EM cleanup activities; (4) S&H resource planning and crosscutting information for FY 1999 to 2001; and (5) Description of indirect-funded S&H activities.

Technology Summary Advancing Tank Waste Retrieval And Processing

International Nuclear Information System (INIS)

Sams, T.L.; Mendoza, R.E.

2010-01-01

This technology overview provides a high-level summary of technologies being investigated and developed by Washington River Protection Solutions (WRPS) to advance Hanford Site tank waste retrieval and processing. Technology solutions are outlined, along with processes and priorities for selecting and developing them. This technology overview provides a high-level summary of technologies being investigated, developed, and deployed by WRPS to advance Hanford Site tank waste retrieval and processing. Transformational technologies are needed to complete Hanford tank waste retrieval and treatment by 12/31/2047. Hanford's underground waste storage tanks hold approximately 57 million gallons of radiochemical waste from nuclear defense production - more tank waste than any other site in the United States. In addition, the waste is uniquely complicated because it contains constituents from at least six major radiochemical processes and several lesser processes. It is intermixed and complexed more than any other waste collection known to exist in the world. The multi-faceted nature of Hanford's tank waste means that legally binding agreements in the Federal Facility Agreement and Consent Order (known as the Tri-Party Agreement) and between the Department of Energy (DOE) and its contractors may not be met using current vitrification schedules, plans, and methods. WRPS and the DOE are developing, testing, and deploying technologies to meet the necessary commitments and complete the DOE's River Protection Project (RPP) mission within environmentally acceptable requirements. Technology solutions are outlined, along with processes and priorities for selecting and developing them. DOE's Office of Environmental Management (EM) identifies the environmental management technology needs and the activities necessary to address them. The U.S. Congress then funds these activities through EM or the DOE field offices. Finally, an array of entities that include DOE site prime contractors and

Executive summary: evaluation of the evidence to support practice guidelines for nutritional care of preterm infants-the Pre-B Project.

Science.gov (United States)

Raiten, Daniel J; Steiber, Alison L; Hand, Rosa K

2016-02-01

Preterm birth (infants born at summary of a workshop hosted by the USDA/ARS Children's Nutrition Research Center and summary reports of the 4 working groups established to address the following themes: 1) nutrient specifications, 2) clinical/practical issues in enteral feeding, 3) gastrointestinal and surgical issues, and 4) current standards for assessing infant feeding outcomes. These reports will serve as the basis for the ultimate guideline development process to be conducted by the Academy of Nutrition and Dietetics' EAL. © 2016 American Society for Nutrition.

Commentary: Mentoring the mentor: executive coaching for clinical departmental executive officers.

Science.gov (United States)

Geist, Lois J; Cohen, Michael B

2010-01-01

Departmental executive officers (DEOs), department chairs, and department heads in medical schools are often hired on the basis of their accomplishments in research as well as their skills in administration, management, and leadership. These individuals are also expected to be expert in multiple areas, including negotiation, finance and budgeting, mentoring, and personnel management. At the same time, they are expected to maintain and perhaps even enhance their personal academic standing for the purposes of raising the level of departmental and institutional prestige and for recruiting the next generation of physicians and scientists. In the corporate world, employers understand the importance of training new leaders in requisite skill enhancement that will lead to success in their new positions. These individuals are often provided with extensive executive training to develop the necessary competencies to make them successful leaders. Among the tools employed for this purpose are the use of personal coaches or executive training courses. The authors propose that the use of executive coaching in academic medicine may be of benefit for new DEOs. Experience using an executive coach suggests that this was a valuable growth experience for new leaders in the institution.

Single-instruction multiple-data execution

CERN Document Server

Hughes, Christopher J

2015-01-01

Having hit power limitations to even more aggressive out-of-order execution in processor cores, many architects in the past decade have turned to single-instruction-multiple-data (SIMD) execution to increase single-threaded performance. SIMD execution, or having a single instruction drive execution of an identical operation on multiple data items, was already well established as a technique to efficiently exploit data parallelism. Furthermore, support for it was already included in many commodity processors. However, in the past decade, SIMD execution has seen a dramatic increase in the set of

Mergeable summaries

DEFF Research Database (Denmark)

Agarwal, Pankaj K.; Graham, Graham; Huang, Zengfeng

2013-01-01

We study the mergeability of data summaries. Informally speaking, mergeability requires that, given two summaries on two datasets, there is a way to merge the two summaries into a single summary on the two datasets combined together, while preserving the error and size guarantees. This property m...

Advancing Understanding of Emissions from Oil and Natural Gas Production Operations to Support EPA’s Air Quality Modeling of Ozone Non-Attainment Areas; Final Summary Report

Science.gov (United States)

Executive Summary Environmentally responsible development of oil and gas assets requires well-developed emissions inventories and measurement techniques to verify emissions and the effectiveness of control strategies. To accurately model the oil and gas sector impacts on air qual...

Executive Orders from 1994-2013

Data.gov (United States)

National Archives and Records Administration — The President of the United States manages the operations of the Executive branch of Government through Executive orders. After the President signs an Executive...

Course Correction: Executive Summary

Science.gov (United States)

Allen, Nicole

2009-01-01

Textbooks are an essential, but increasingly expensive part of obtaining a college degree. Digital textbooks are a promising way to lower costs for students. The digital format has the potential to cut production costs, increase options for students, and open up the market to more competition. Digital textbooks are now beginning to gain a more…

Executive Summary - Historical background

International Nuclear Information System (INIS)

2005-01-01

The Institute of Nuclear Physics (INP) was established in Cracow in 1955. The post-war excitement of engaging in scientific activity, can certainly be credited to the talent, experience and unusual personality of Professor Henryk Niewodniczanski, the founder and first Director of the INP. In the 60's the INP research activity was concentrated around the Russian U120 Cyclotron, built in 1958 which provided deuteron beams up to 14.5 MeV and of alpha particles up to 29 MeV. A small 48 cm pole-piece cyclotron with was in-house constructed, and used for PIXE analyses and RBA material studies. In 1960's, the nuclear spectroscopy group began building several types of magnetic beta ray spectrometers to study excited levels of neutron-deficient isotopes provided by the 660 MeV cyclotron of the JINR. In parallel, studies of spin polarization of n and p emitted in the deuteron stripping reaction were performed. Studies of condensed matter using pulsed neutron beams from the IBR30 and Kjeller (Norway) reactors had also began. The NMR signal was first observed in Poland by physicists from the Jagiellonian University, and a well equipped NMR Laboratory was also created at the INP. A small theoretical physics department was established to support experimental research. Applied physics, based on the research performed in the INP was also developed. Following the interest in fast neutron radiotherapy, initiated by the Gray Laboratory in Hammersmith, a beam of fast neutrons was produced on a Be target by 13.5 MeV deuterons from the U120 and applied for cancer therapy, in a collaborative effort with the Centre of Oncology in Cracow. Over a period of 10 years, some 500 patients were treated, in selected types of salivary gland cancer and post-mastectomy recurrences. In the late 60's a technology of thermoluminescent dosimeters (TLD) was developed at the INP, based on specially activated LiF. The method was patented and TLDs, manufactured at the INP, are nowadays applied by in over 30 countries. The INP had an important role to play during and after the Chernobyl accident, by serving the population with measurements of radioactive contamination of air, soil and food. This work is being continued, with a permanent early-warning and monitoring station at the INP, an element of the national radiation monitoring system. After 38 years of operation the U-120 cyclotron was replaced by an inhouse constructed 144 cm pole-piece AIC-144 one able to accelerate protons up to 60 MeV, which is now used to produce short-lived beta-plus isotopes and will be able to provide a proton beam for treating ocular melanoma. The small 48-cm cyclotron was replaced by a 2.5 MeV Van de Graaff accelerator. With a microbeam capacity, it serves to continue and further develop the interdisciplinary research in cell biology, archaeology and material structure. The particle and high energy physics group, which joined the INP in 1970 (and had originated from the Cosmic Ray Studies group initiated in 1938 by Professor Marian Miesowicz at the Academy of Mining and Metallurgy) was initially connected with accelerators of the JINR and later was able to expand to CERN and DESY. The theoretical physics group had also expanded, engaging in particle theory and astrophysics. We take part in assembling the LHC. We entered the ATLAS, ALICE, and LHCb collaborations and may possibly join the CASTOR project. We took part in constructing the HERA collider and are collaborators in the large ZEUS and H1 projects. We joined the TESLA project. Within the ZEUS collaboration we built the luminosity detector. At the RHIC collider we constructed a large part of the PHOBOS detector and within this collaboration we made a contribution to the discovery of the new state of hadronic matter. Within the BELLE collaboration at KEK we took part in the measurements of the CP violation effects in the B mesons decay. Our scientists participate in experiments performed at GANIL, Legnaro and GSI. We carry out condensed matter physics experiments at the High Flux Reactor of The Laue Langevin Institute and the ISIS spallation source at Rutherford-Appleton. Recently, we very actively entered the ICARUS neutrino collaboration and were invited to the PIERRE AUGER collaboration which will search for the highest energies in the Universe. Having close ties with CERN we are very actively engaged in CROSS-GRID, a large computer network project. To better understand the historical background of the INP development, it is necessary to add a few comments on financing of science in Poland. During the 70's and the 80's, research was financed through the so-called Central Research Projects for Science and Technical Development. The advantage of this system was that state-allocated research funds were divided only by a few representatives of the scientific community, which allowed realistic allocation of money to a small number of projects. After 1989 we were able to purchase commercially available equipment, which led to the closure of our large and very experienced electronic workshop. We also considerably reduced our well equipped mechanical shop. During the 90's the reduced state financing of science was accompanied by a newly established Committee of Scientific Research which led to the creation of a system of small research projects. This precluded the development of more ambitious research projects and led to the dispersion of equipment among many smaller laboratories and universities. A large research establishment, such as our Institute, could not develop properly under such conditions. In all, between 1989 and 2004 we reduced our personnel from about 800 to 470 and our infrastructure became seriously undercapitalised. However, with energetic search for research funds, from European rather than national research programs, we hope to improve and modernize our laboratories and their infrastructure in the coming years

Executive Summary - Our mission

International Nuclear Information System (INIS)

2007-01-01

Full text: The Henryk Niewodniczanski Institute of Nuclear Physics (Instytut Fizyki Jadrowej im. Henryka Niewodniczanskiego, IFJ PAN) is currently the largest research institution of the Polish Academy of Sciences (Polska Akademia Nauk). The research activity of the Academy is financed mainly from the State budget via the Ministry of Science and Higher Education. The mission of IFJ PAN is stated in its Charter. According to Paragraphs 5, 6, and 7 of the 2004 Charter, the Institute's duty is to carry out research activities in the following areas: 1. High energy and elementary particle physics (including astrophysics), 2. Nuclear physics and strong interaction, 3. Condensed matter physics, 4. Interdisciplinary research, in particular: in radiation and environmental biology, environmental physics, medical physics, dosimetry, nuclear geophysics, radiochemistry and material engineering. The main tasks of the Institute are: 1. To perform research in the above disciplines, 2. To promote the development of scientists and of specialists qualified to carry out research in these disciplines, 3. To organize a Post-Graduate Study Course, 4. To permit, through agreements with national and foreign research institutions, external scholars to train and gain academic qualifications in the Institute's laboratories, 5. To collaborate with national and local authorities in providing them with expertise in the Institute's research topics, especially concerning radiation protection. These tasks are fulfilled by: 1. Performing individual and coordinated research through individual and collective research grant projects, 2. Initiating and maintaining cooperation with laboratories, organizations and institutions performing similar activities, in Poland and abroad, 3. Conferring scientific degrees and titles, 4. Distributing research results obtained, through peer-reviewed publications and other public media, 5. Organizing scientific meetings, conferences, symposia, training workshops, etc., 6. Providing expertise and analytic reports to government institutions and local authorities, 7. Carrying out other duties, within the statutory mandate of the Institute. In November 2004 the president of the Polish Academy of Sciences, Prof. A. Legocki, constituted the Scientific Advisory Board, SAB, to review the scientific activities of the Institute. The Board was asked to assess the present state of IFJ PAN, in particular the quality of its research as measured on an international scale and to provide recommendations in order for the Institute to strengthen its position and future research goals. The first review took place in February 2005 and in March 2005 SAB formulated its recommendations. SAB stressed the need to maintain and strengthen the role of fundamental research and to cultivate its strong links with the international scientific community, particularly with large laboratories such as CERN, DESY, GANIL, GSI, and ILL. In applied sciences IFJ PAN should remain attractive for Polish scientists, particularly to continue to make use of some of its unique facilities and laboratories. SAB also recommended to maintain the funding of the high level engineering and technical support, which gives a unique opportunity to support the new experiments in physics. It was also underlined that the role of young people in leading positions should be strengthened. (author)

Artificial intelligence executive summary

International Nuclear Information System (INIS)

Wamsley, S.J.; Purvis, E.E. III

1984-01-01

Artificial intelligence (AI) is a high technology field that can be used to provide problem solving diagnosis, guidance and for support resolution of problems. It is not a stand alone discipline, but can also be applied to develop data bases for retention of the expertise that is required for its own knowledge base. This provides a way to retain knowledge that otherwise may be lost. Artificial Intelligence Methodology can provide an automated construction management decision support system, thereby restoring the manager's emphasis to project management

WEO-2011 Executive Summary

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-07-01

There are few signs that the urgently needed change in direction in global energy trends is underway. Although the recovery in the world economy since 2009 has been uneven, and future economic prospects remain uncertain, global primary energy demand rebounded by a remarkable 5% in 2010, pushing CO2 emissions to a new high. Subsidies that encourage wasteful consumption of fossil fuels jumped to over $400 billion. The number of people without access to electricity remained unacceptably high at 1.3 billion, around 20% of the world's population. Despite the priority in many countries to increase energy efficiency, global energy intensity worsened for the second straight year. Against this unpromising background, events such as those at the Fukushima Daiichi nuclear power plant and the turmoil in parts of the Middle East and North Africa (MENA) have cast doubts on the reliability of energy supply, while concerns about sovereign financial integrity have shifted the focus of government attention away from energy policy and limited their means of policy intervention, boding ill for agreed global climate change objectives.

Executive Summary - Our mission

International Nuclear Information System (INIS)

2005-01-01

On September 1 st 2003, the Henryk Niewodniczanski Institute of Nuclear Physics in Cracow joined the Polish Academy of Sciences. The Polish Academy of Sciences (PAN), founded in 1952, is a state-sponsored scientific institution acting through an elected corporation of leading scholars, their research organizations and through numerous scientific establishments. PAN is a major national scientific advisory body acting via its scientific committees which represent all disciplines of science. There are currently 79 PAN research establishments (institutes and research centers, research stations, botanical gardens and other research units) and a number of auxiliary scientific units (such as archives, libraries, museums, and PAN stations abroad). Our Institute is currently one of the largest research institutions of the Polish Academy of Sciences. The research activity of the Academy is financed mainly from the State budget via the Ministry of Scientific Research and Information Technology. The mission of the Institute of Nuclear Physics, IFJ is stated in its Charter. According to Paragraphs 5, 6, and 7 of the 2004 Charter, the Institute's duty is to carry out research activities in the following areas:1. High energy and elementary particle physics (including astrophysics), 2. Nuclear physics and physics of mechanisms of nuclear interaction, 3. Condensed matter physics, 4. Interdisciplinary research, and in particular: in radiation and environmental biology, environmental physics, medical physics, dosimetry, nuclear geophysics, radiochemistry and material engineering. The main tasks of the Institute are: 1. To perform research in the above disciplines, 2. To promote the development of scientists and of specialists qualified to carry out research in these disciplines, 3. To organize a Post-Doctoral Study Course, 4. To permit, through agreements with national and foreign research institutions, external scholars to train and gain academic qualifications in the Institute's laboratories, 5. To collaborate with national and local authorities in providing them with expertise in the Institute's research topics, especially concerning radiation protection. These tasks are fulfilled by: 1. Performing individual and coordinated research through individual and collective research grant projects, 2. Initiating and maintaining cooperation with laboratories, organizations and institutions performing similar activities, in Poland and abroad, 3. Conferring scientific degrees and titles, 4. Distributing research results obtained, through peer-reviewed publications and other public media, 5. Organizing scientific meetings, conferences, symposia, training workshops, etc., 6. Providing expertise and analytic reports to government institutions and local authorities, 7. Carrying out other duties, within the statutory mandate of the Institute

Chapter 0: Executive summary

International Nuclear Information System (INIS)

1995-01-01

This chapter deals with the background (Gabcikovo hydro power scheme was input in October 1992), project objective, project framework, equipment, establishment of the integrated modelling system, model setup, calibration and validation, definitions of scenarios for model application and with the results of model applications

Executive Summary - Future plans

International Nuclear Information System (INIS)

2005-01-01

Our Institute has sufficient scientific potential to play a key role in the field of particle physics, nuclear physics and in several aspects of solid state and applied physics, at least in our part of Europe. We believe the Institute should continue its present mode of operation, where basic research, closely coordinated through our collaboration with leading laboratories all over the world, stimulates our interdisciplinary research and technology transfer to the industry. If our present scientific potential is matched by suitably modernized infrastructure, we should be able to acquire the critical mass necessary for further effective development. In order to maintain our present world-level research, we have to continue and further extend our participation in large international collaborations, in the construction of large detectors and to seek further financial support from EU and international organizations. For experimental particle physics, our priorities remain in collaborating with major European and world laboratories such as CERN, DESY, Gran Sasso, Fermilab, KEK, SLAC and with laboratories developing astrophysics experiments, such as the PIERRE AUGER experiment. Collaboration in the field of nuclear physics, physics of condensed matter, theoretical physics and interdisciplinary research should be continued with leading European laboratories offering access to large accelerator facilities (such as GANIL or GSI), to synchrotron radiation or to unique polarized neutron beams, such as those available at ILL Grenoble. An exiting new frontier in research for our research teams will be opened by the X-ray Free Electron Laser (XFEL) in DESY and the future International Linear Collider. We will be able to further invest towards upgrading our small-scale facilities, such as the infrastructure around the Van de Graaff accelerator, in order to perform single-ion beam experiments, or around the AIC-144 cyclotron, to treat ocular melanoma, in close collaboration with ophthalmologists at the Collegium Medicum (Jagiellonian University) and radiotherapists at the Centre of Oncology. Our Institute is capable of providing PET isotopes to the local medical community. We will continue to upgrade our technical infrastructure and research equipment basing on Structural Funds of the European Commission. We are able to achieve this through our Centres of Excellence and Centres of Advanced Technologies. We will further continue to strongly support the application of methods of nuclear physics in biological and medical research, such as single-ion studies of the effects of low-radiation doses, Nuclear Magnetic Resonance research in physiology, the Atomic Force microscope for studying properties of cell and membranes, the chromosome aberration/DNA studies for biological dosimetry, or advanced dosimetry techniques for medical physics and space dosimetry. We shall also continue our obligation to serve the national and local authorities with our expertise in radiation protection and dosimetry. We intend to further support the development of geophysical methods for searching natural resources. In view of the current discussion on the future sources of energy in Poland, our Institute will actively engage in promoting nuclear energy, based on new-generation reactor technology. We will be actively seeking the opportunity of maintaining the tradition of our Institute being focused around its major accelerator facility. While the present AIC-144 cyclotron is no longer adequate for treatment of deep-seated tumors, a medium-sized synchrotron able to accelerate light ions to energies of some several hundred MeV/amu, capable of generating ion beams suitable for light-ion radiotherapy, could fulfill this role, stimulating a renewal of our past close collaboration with radiotherapists in fighting cancer. Such radiotherapy centres are currently under development in other parts of the European Community. We will actively seek the opportunities to obtain external funding for this purpose. However, we are fully aware of the difficulty of introducing cutting-edge medical technology to the Polish national health care system, in view of the immediate needs of this seriously undercapitalized service of our 40-million community. We need to devote special attention to further training our personnel. The present potential of the Institute allows our research group to participate in the most ambitious projects and collaborations. Availability of such highly educated and experienced technical staff is absolutely essential for performing this type of work. Such personnel is not usually available at universities, where the potential is spread-out to a much larger extent. We would like to maintain our group of engineers specialized in the development and construction of detectors, dedicated electronics and software needed for experimental physics. One of the principal goals of the Institute is to promote professional careers of young researchers in Poland. We would like to increase the participation of undergraduate and graduate (Ph.D.) students and short-term postdoctoral researchers, originating from Europe and outside, in activities of the research groups in the Institute. We plan to strengthen our cooperation with universities and technical universities in southern Poland (Cracow, Rzeszow, Kielce, Katowice and others) by teaching students and providing our laboratories and expertise to help them complete their theses. Further development of our International Post-Graduate Study Course, in collaboration with other institutions in the European Research Area, will be strongly supported

75 FR 55574 - Joint Public Roundtable on Swap Execution Facilities and Security-Based Swap Execution Facilities

Science.gov (United States)

2010-09-13

...; File No. 4-612] Joint Public Roundtable on Swap Execution Facilities and Security-Based Swap Execution Facilities AGENCY: Commodity Futures Trading Commission (``CFTC'') and Securities and Exchange Commission... discuss swap execution facilities and security-based swap execution facilities in the context of certain...

Concurrent Models for Object Execution

OpenAIRE

Diertens, Bob

2012-01-01

In previous work we developed a framework of computational models for the concurrent execution of functions on different levels of abstraction. It shows that the traditional sequential execution of function is just a possible implementation of an abstract computational model that allows for the concurrent execution of functions. We use this framework as base for the development of abstract computational models that allow for the concurrent execution of objects.

Executive Summary of the American College of Surgeons/Surgical Infection Society Surgical Site Infection Guidelines-2016 Update.

Science.gov (United States)

Ban, Kristen A; Minei, Joseph P; Laronga, Christine; Harbrecht, Brian G; Jensen, Eric H; Fry, Donald E; Itani, Kamal M F; Dellinger, E Patchen; Ko, Clifford Y; Duane, Therese M

Guidelines regarding the prevention, detection, and management of surgical site infections (SSIs) have been published previously by a variety of organizations. The American College of Surgeons (ACS)/Surgical Infection Society (SIS) Surgical Site Infection (SSI) Guidelines 2016 Update is intended to update these guidelines based on the current literature and to provide a concise summary of relevant topics.

Executive functions predict weight loss in a medically supervised weight loss programme

Science.gov (United States)

Bond, D.; Gunstad, J.; Pera, V.; Rathier, L.; Tremont, G.

2016-01-01

Summary Background Deficits in executive functions are related to poorer weight loss after bariatric surgery; however, less is known about the role that these deficits may play during participation in nonsurgical weight loss programmes. This study examined associations between objectively measured executive functions and weight loss during participation in a medically supervised weight loss programme. Methods Twenty‐three adult patients (age 50.4 ± 15.1, BMI 44.2 ± 8.8, 68% female, 92% White) enrolled in a medically supervised weight loss programme, involving prescription of a very low calorie diet and strategies to change eating and activity behaviours, underwent comprehensive computerized testing of executive functions at baseline. Weight was obtained at baseline and 8 weeks. Demographic and clinical information were obtained through medical chart review. Results Participants lost an average of 9.8 ± 3.4% of their initial body weight at 8 weeks. Fewer correct responses on a set‐shifting task and faster reaction time on a response inhibition task were associated with lower weight loss percentage at 8 weeks after adjusting for age, education and depressive symptoms. There were no associations between performance on tests of working memory or planning and weight loss. Conclusions This study shows that worse performance on a set‐shifting task (indicative of poorer cognitive flexibility) and faster reaction times on a response inhibition test (indicative of higher impulsivity) are associated with lower weight loss among participants in a medically supervised weight loss programme. Pre‐treatment assessment of executive functions may be useful in identifying individuals who may be at risk for suboptimal treatment outcomes. Future research is needed to replicate these findings in larger samples and identify underlying mechanisms. PMID:28090338

Executive Energy Leadership Academy | NREL

Science.gov (United States)

Executive Energy Leadership Academy Executive Energy Leadership Academy NREL's Executive Energy Leadership Academy is a nationally renowned program that provides non-technical business, governmental, and foreground. Leadership Program The Leadership Program is designed for community and industry leaders with an

Research in the chemical sciences. Summaries of FY 1995

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-09-01

This summary book is published annually to provide information on research supported by the Department of Energy`s Division of Chemical Sciences, which is one of four Divisions of the Office of Basic Energy Sciences in the Office of Energy Research. These summaries provide the scientific and technical public, as well as the legislative and executive branches of the Government, information, either generally or in some depth, about the Chemical Sciences program. Scientists interested in proposing research for support will find the publication useful for gauging the scope of the present basic research program and it`s relationship to their interests. Proposals that expand this scope may also be considered or directed to more appropriate offices. The primary goal of the research summarized here is to add significantly to the knowledge base in which existing and future efficient and safe energy technologies can evolve. As a result, scientific excellence is a major criterion applied in the selection of research supported by the Division of Chemical Sciences, but another important consideration is emphasis on science that is advancing in ways that will produce new information related to energy.

Educating Executive Function

Science.gov (United States)

Blair, Clancy

2016-01-01

Executive functions are thinking skills that assist with reasoning, planning, problem solving, and managing one’s life. The brain areas that underlie these skills are interconnected with and influenced by activity in many different brain areas, some of which are associated with emotion and stress. One consequence of the stress-specific connections is that executive functions, which help us to organize our thinking, tend to be disrupted when stimulation is too high and we are stressed out, or too low when we are bored and lethargic. Given their central role in reasoning and also in managing stress and emotion, scientists have conducted studies, primarily with adults, to determine whether executive functions can be improved by training. By and large, results have shown that they can be, in part through computer-based videogame-like activities. Evidence of wider, more general benefits from such computer-based training, however, is mixed. Accordingly, scientists have reasoned that training will have wider benefits if it is implemented early, with very young children as the neural circuitry of executive functions is developing, and that it will be most effective if embedded in children’s everyday activities. Evidence produced by this research, however, is also mixed. In sum, much remains to be learned about executive function training. Without question, however, continued research on this important topic will yield valuable information about cognitive development. PMID:27906522

Executive summary: Weldon Spring Site Environmental Report for calendar year 1992

International Nuclear Information System (INIS)

1993-06-01

This report has been prepared to provide information about the public safety and environmental protection programs conducted by the Weldon Spring Site Remedial Action Project. The Weldon Spring site is located in southern St. Charles County, Missouri, approximately 48 km (30 mi) west of St. Louis. The site consists of two main areas, the Weldon Spring Chemical Plant and raffinate pits and the Weldon Spring Quarry. The objectives of the Site Environmental Report are to present a summary of data from the environmental monitoring program, to characterize trends and environmental conditions at the site, and to confirm compliance with environmental and health protection standards and requirements. The report also presents the status of remedial activities and the results of monitoring these activities to assess their impacts on the public and environment. The scope of the environmental monitoring program at the Weldon Spring site has changed since it was initiated. Previously, the program focused on investigations of the extent and level of contaminants in the groundwater, surface waters, buildings, and air at the site. In 1992, the level of remedial activities required monitoring for potential impacts of those activities, particularly on surface water runoff and airborne effluents. This report includes monitoring data from routine radiological and nonradiological sampling activities. These data include estimates of dose to the public from the Weldon Spring site; estimates of effluent releases; and trends in groundwater contaminant levels. Also, applicable compliance requirements, quality assurance programs, and special studies conducted in 1992 to support environmental protection programs are reviewed

Spaceborne computer executive routine functional design specification. Volume 2: Computer executive design for space station/base

Science.gov (United States)

Kennedy, J. R.; Fitzpatrick, W. S.

1971-01-01

The computer executive functional system design concepts derived from study of the Space Station/Base are presented. Information Management System hardware configuration as directly influencing the executive design is reviewed. The hardware configuration and generic executive design requirements are considered in detail in a previous report (System Configuration and Executive Requirements Specifications for Reusable Shuttle and Space Station/Base, 9/25/70). This report defines basic system primitives and delineates processes and process control. Supervisor states are considered for describing basic multiprogramming and multiprocessing systems. A high-level computer executive including control of scheduling, allocation of resources, system interactions, and real-time supervisory functions is defined. The description is oriented to provide a baseline for a functional simulation of the computer executive system.

Glycolytic metabolite methylglyoxal inhibits cold and menthol activation of the transient receptor potential melastatin type 8 channel.

Science.gov (United States)

Ciobanu, A C; Selescu, T; Gasler, I; Soltuzu, L; Babes, A

2016-03-01

Methylglyoxal (MG) is a reactive dicarbonyl compound involved in protein modifications linked to diabetes mellitus. The plasma level of MG is elevated in diabetic patients, particularly those with painful diabetic neuropathy. Diabetic neuropathy is often associated with spontaneous pain and altered thermal perception. This study assesses effects of MG on TRPM8, an ion channel involved in innocuous cold sensing and cold allodynia and also in cold-mediated analgesia. Acute treatment with MG inhibited the activation of recombinant rat and human transient receptor potential melastatin type 8 (TRPM8) by cold and chemical agonists. A similar effect was observed when native TRPM8 was investigated in cultured rat dorsal root ganglion (DRG) neurons. DRG neurons treated with MG for 16-24 hr displayed a significant reduction in the fraction of cold- and menthol-sensitive neurons, most likely expressing TRPM8. The fraction of allyl isothiocyanate-sensitive neurons was also reduced, and the coexpression among different neuronal populations was affected. The same prolonged exposure to MG significantly reduced the expression of TRPM8 at the mRNA level. Overall, our data provide evidence for decreased activity and expression level of TRPM8 in the presence of MG, which may be linked to some of the alterations in pain and temperature sensing reported by diabetic patients. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

Regulatory licensing status summary report. Nuclear power plants data for decisions (blue book), June 17-July 10, 1982

International Nuclear Information System (INIS)

1982-07-01

This management report, Regulatory Licensing Status Summary Report, is designed to provide the necessary information for controlling the progress of review processes for central station nuclear reactor applications. It utilizes data collected from the Office of Nuclear Reactor Regulation, Office of the Executive Legal Director, Office of Inspection and Enforcement, and the National Laboratories, and analyzed by the Office of Resource Management in the implementation of the Regulatory Information System. Section I of this edition consists of the three summary of accomplishments, the new application forecast for OL's and CP's, and an abbreviation key. Section II represents the main body of the report and consists of the facility information. All OL's are listed first, followed by CP's, standard design reviews, other reviews, and finally, a non-power reactor summary. Each project consists of general facility data, current status for all phases of the review, and targeted and actual completion dates for all key milestones in the review

Regulatory licensing status summary report. Nuclear power plants data for decisions (blue book), April 20-May 15, 1982

International Nuclear Information System (INIS)

1982-01-01

This management report, regulatory licensing status summary report, is designed to provide the necessary information for controlling the progress of review processes for central station nuclear reactor applications. It utilizes data collected from the Office of Nuclear Reactor Regulation, Office of the Executive Legal Director, Office of Inspection and Enforcement, and the National Laboratories, and analyzed by the Office of Resource Management in the implementation of the regulatory information system. Section I of this edition consists of the three summary of accomplishments, the new application forecast for OL's and CP's, and an abbreviation key. Section II represents the main body of the report and consists of the facility information. All OL's are listed first, followed by CP's, standard design reviews, other reviews, and finally, a non-power reactor summary. Each project consists of general facility data, current status for all phases of the review, and targeted and actual completion dates for all key milestones in the review

A competence executive coaching model

Directory of Open Access Journals (Sweden)

Pieter Koortzen

2010-07-01

Research purpose: The purpose of this article is to address the training and development needs of these consulting psychologists by presenting a competence executive coaching model for the planning, implementation and evaluation of executive coaching interventions. Research design, approach and method: The study was conducted while one of the authors was involved in teaching doctoral students in consulting psychology and executive coaching, specifically in the USA. The approach involved a literature review of executive coaching models and a qualitative study using focus groups to develop and evaluate the competence executive coaching model. Main findings: The literature review provided scant evidence of competence executive coaching models and there seems to be a specific need for this in the training of coaches in South Africa. Hence the model that was developed is an attempt to provide trainers with a structured model for the training of coaches. Contribution/value-add: The uniqueness of this competence model is not only described in terms of the six distinct coaching intervention phases, but also the competencies required in each.

Educating executive function.

Science.gov (United States)

Blair, Clancy

2017-01-01

Executive functions are thinking skills that assist with reasoning, planning, problem solving, and managing one's life. The brain areas that underlie these skills are interconnected with and influenced by activity in many different brain areas, some of which are associated with emotion and stress. One consequence of the stress-specific connections is that executive functions, which help us to organize our thinking, tend to be disrupted when stimulation is too high and we are stressed out, or too low when we are bored and lethargic. Given their central role in reasoning and also in managing stress and emotion, scientists have conducted studies, primarily with adults, to determine whether executive functions can be improved by training. By and large, results have shown that they can be, in part through computer-based videogame-like activities. Evidence of wider, more general benefits from such computer-based training, however, is mixed. Accordingly, scientists have reasoned that training will have wider benefits if it is implemented early, with very young children as the neural circuitry of executive functions is developing, and that it will be most effective if embedded in children's everyday activities. Evidence produced by this research, however, is also mixed. In sum, much remains to be learned about executive function training. Without question, however, continued research on this important topic will yield valuable information about cognitive development. WIREs Cogn Sci 2017, 8:e1403. doi: 10.1002/wcs.1403 For further resources related to this article, please visit the WIREs website. © 2016 Wiley Periodicals, Inc.

Essays in Executive Compensation

NARCIS (Netherlands)

D. Zhang (Dan)

2012-01-01

textabstractThis dissertation focuses on how executive compensation is designed and its implications for corporate finance and government regulations. Chapter 2 analyzes several proposals to restrict CEO compensation and calibrates two models of executive compensation that describe how firms would

Executive Function in Children with Attention Deficit/Hyperactivity Disorder: the NIH EXAMINER battery

Science.gov (United States)

Schreiber, Jane E.; Possin, Katherine L.; Girard, Jonathan M.; Rey-Casserly, Celiane

2014-01-01

Theories of ADHD increasingly highlight the role of neuropsychological impairment in ADHD; however, a consistent and identifiable pattern of performance on tests is not well established. The NIH EXAMINER battery provides measures of common variance across multiple executive function tests within specific domains and was used to characterize which executive functions are most affected in children with ADHD. Thirty-two children (24 male), ages 8–15 years (M=12.02, SD=2.29), diagnosed with ADHD and no comorbid disorder completed the NIH EXAMINER battery. Sixty age and gender matched healthy controls were chosen from a database of participants enrolled in the NIH EXAMINER multi-site study. Children with ADHD performed worse on the working memory score compared with the controls. No differences were found on the cognitive control or fluency scores. For children with ADHD, poorer working memory performance predicted parent report of child learning problems. Cognitive control and fluency scores did not predict learning problems. In summary, working memory emerges as a primary impairment in children with ADHD who have no comorbid disorders. Furthermore, working memory weaknesses may underlie the academic problems often seen in children with ADHD. PMID:24103310

Uranium enrichment management review: summary of analysis

International Nuclear Information System (INIS)

1981-01-01

In May 1980, the Assistant Secretary for Resource Applications within the Department of Energy requested that a group of experienced business executives be assembled to review the operation, financing, and management of the uranium enrichment enterprise as a basis for advising the Secretary of Energy. After extensive investigation, analysis, and discussion, the review group presented its findings and recommendations in a report on December 2, 1980. The following pages contain background material on which that final report was based. This report is arranged in chapters that parallel those of the uranium enrichment management review final report - chapters that contain summaries of the review group's discussion and analyses in six areas: management of operations and construction; long-range planning; marketing of enrichment services; financial management; research and development; and general management. Further information, in-depth analysis, and discussion of suggested alternative management practices are provided in five appendices

Uranium enrichment management review: summary of analysis

Energy Technology Data Exchange (ETDEWEB)

1981-01-01

In May 1980, the Assistant Secretary for Resource Applications within the Department of Energy requested that a group of experienced business executives be assembled to review the operation, financing, and management of the uranium enrichment enterprise as a basis for advising the Secretary of Energy. After extensive investigation, analysis, and discussion, the review group presented its findings and recommendations in a report on December 2, 1980. The following pages contain background material on which that final report was based. This report is arranged in chapters that parallel those of the uranium enrichment management review final report - chapters that contain summaries of the review group's discussion and analyses in six areas: management of operations and construction; long-range planning; marketing of enrichment services; financial management; research and development; and general management. Further information, in-depth analysis, and discussion of suggested alternative management practices are provided in five appendices.

Gradual linguistic summaries

NARCIS (Netherlands)

Wilbik, A.M.; Kaymak, U.; Laurent, A.; Strauss, O.; Bouchon-Meunier, xx

2014-01-01

In this paper we propose a new type of protoform-based linguistic summary – the gradual summary. This new type of summaries aims in capturing the change over some time span. Such summaries can be useful in many domains, for instance in economics, e.g., "prices of X are getting smaller" in eldercare,

Recommendations for an Executive Information System (EIS) for the NASA Accounting and Financial Information System (NAFIS)

Science.gov (United States)

Goss, Ernest Preston

1991-01-01

The objectives were to: (1) survey state-of-the-art computing architectures, tools, and technologies for implementing an Executive Information System (EIS); (2) review MSFC capabilities and efforts in developing an EIS for Shuttle Projects Office and the Payloads Project Office; (3) review management reporting requirements for the NASA Accounting and Financial Information System (NAFIS) Project in the areas of cost, schedule, and technical performance, and insure that the EIS fully supports these requirements; and (4) develop and implement a pilot concept for a NAFIS EIS. A summary of the findings of this work is presented.

Executive functioning in pre-school children with autism spectrum disorders: The relationship between executive functioning and language

OpenAIRE

Linnerud, Ida Cathrine Wang

2014-01-01

Background: Executive function difficulties are prevalent in children with autism spectrum disorders (ASD) and there are several indications of a modifying relationship between executive functions and language in children. However, there is limited research on the relationship between executive functioning and language in young children with ASD. The current study compared real-world executive functioning between groups of children with ASD, language disorders (LD), and typical development (T...

20% Wind Energy by 2030: Increasing Wind Energy's Contribution to U.S. Electricity Supply; Executive Summary (Revised)

Energy Technology Data Exchange (ETDEWEB)

2008-12-01

This document is a 21-page summary of the 200+ page analysis that explores one clearly defined scenario for providing 20% of our nation's electricity demand with wind energy by 2030 and contrasts it to a scenario of no new U.S. wind power capacity.

Television and children's executive function.

Science.gov (United States)

Lillard, Angeline S; Li, Hui; Boguszewski, Katie

2015-01-01

Children spend a lot of time watching television on its many platforms: directly, online, and via videos and DVDs. Many researchers are concerned that some types of television content appear to negatively influence children's executive function. Because (1) executive function predicts key developmental outcomes, (2) executive function appears to be influenced by some television content, and (3) American children watch large quantities of television (including the content of concern), the issues discussed here comprise a crucial public health issue. Further research is needed to reveal exactly what television content is implicated, what underlies television's effect on executive function, how long the effect lasts, and who is affected. © 2015 Elsevier Inc. All rights reserved.

Rehabilitation research at the National Institutes of Health moving the field forward (executive summary).

Science.gov (United States)

Frontera, Walter R; Bean, Jonathan F; Damiano, Diane; Ehrlich-Jones, Linda; Fried-Oken, Melanie; Jette, Alan; Jung, Ranu; Lieber, Rick L; Malec, James F; Mueller, Michael J; Ottenbacher, Kenneth J; Tansey, Keith E; Thompson, Aiko

2017-08-01

Approximately 53 million Americans live with a disability. For decades, the National Institutes of Health (NIH) has been conducting and supporting research to discover new ways to minimize disability and enhance the quality of life of people with disabilities. After the passage of the Americans With Disabilities Act, NIH established the National Center for Medical Rehabilitation Research, with the goal of developing and implementing a rehabilitation research agenda. Currently, 17 institutes and centers at NIH invest more than $500 million per year in rehabilitation research. Recently, the director of NIH, Francis Collins, appointed a Blue Ribbon Panel to evaluate the status of rehabilitation research across institutes and centers. As a follow-up to the work of that panel, NIH recently organized a conference, "Rehabilitation Research at NIH: Moving the Field Forward." This report is a summary of the discussions and proposals that will help guide rehabilitation research at NIH in the near future. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Rehabilitation Research at the National Institutes of Health: Moving the Field Forward (Executive Summary)

Science.gov (United States)

Frontera, Walter R.; Bean, Jonathan F.; Damiano, Diane; Ehrlich-Jones, Linda; Fried-Oken, Melanie; Jette, Alan; Jung, Ranu; Lieber, Rick L.; Malec, James F.; Mueller, Michael J.; Ottenbacher, Kenneth J.; Tansey, Keith E.; Thompson, Aiko

2017-01-01

Approximately 53 million Americans live with a disability. For decades, the National Institutes of Health (NIH) has been conducting and supporting research to discover new ways to minimize disability and enhance the quality of life of people with disabilities. After the passage of the Americans With Disabilities Act, NIH established the National Center for Medical Rehabilitation Research, with the goal of developing and implementing a rehabilitation research agenda. Currently, 17 institutes and centers at NIH invest more than $500 million per year in rehabilitation research. Recently, the director of NIH, Francis Collins, appointed a Blue Ribbon Panel to evaluate the status of rehabilitation research across institutes and centers. As a follow-up to the work of that panel, NIH recently organized a conference, “Rehabilitation Research at NIH: Moving the Field Forward.” This report is a summary of the discussions and proposals that will help guide rehabilitation research at NIH in the near future. PMID:28422639

Intermediate photovoltaic system application experiment operational performance executive summary. Volume 4. For Beverly High School, Beverly, MA

Energy Technology Data Exchange (ETDEWEB)

1982-02-01

Performance data are given for a 100 kW grid-connected flat panel photovoltaic power supply at a Massachusetts high school for the month of January, 1982. Data given include daily and monthly electrical energy produced, daily and monthly plane-of-array solar energy incident, array efficiency, power conditioner efficiency, system efficiency, capacity factor, and average plane-of-array insolation. Also included are the data acquisition mode and recording interval plot and two site event report summaries involving the data acquisition system. (LEW)

Assessing Executive Functioning: A Pragmatic Review

Science.gov (United States)

Hass, Michael R.; Patterson, Ashlea; Sukraw, Jocelyn; Sullivan, Brianna M.

2014-01-01

Despite the common usage of the term "executive functioning" in neuropsychology, several aspects of this concept remain unsettled. In this paper, we will address some of the issues surrounding the notion of executive functioning and how an understanding of executive functioning and its components might assist school-based practitioners…

Guidelines for Automation Project Execution

OpenAIRE

Takkinen, Heidi

2011-01-01

The purpose of this Master’s thesis was to create instructions for executing an automation project. Sarlin Oy Ab needed directions on how to execute an automation project. Sarlin is starting up a new business area offering total project solutions for customers. Sarlin focuses on small and minor automation projects on domestic markets. The thesis represents issues related to project execution starting from the theory of the project to its kick-off and termination. Site work is one importan...

Assessment of display performance for medical imaging systems: Executive summary of AAPM TG18 report

International Nuclear Information System (INIS)

Samei, Ehsan; Badano, Aldo; Chakraborty, Dev

2005-01-01

Digital imaging provides an effective means to electronically acquire, archive, distribute, and view medical images. Medical imaging display stations are an integral part of these operations. Therefore, it is vitally important to assure that electronic display devices do not compromise image quality and ultimately patient care. The AAPM Task Group 18 (TG18) recently published guidelines and acceptance criteria for acceptance testing and quality control of medical display devices. This paper is an executive summary of the TG18 report. TG18 guidelines include visual, quantitative, and advanced testing methodologies for primary and secondary class display devices. The characteristics, tested in conjunction with specially designed test patterns (i.e., TG18 patterns), include reflection, geometric distortion, luminance, the spatial and angular dependencies of luminance, resolution, noise, glare, chromaticity, and display artifacts. Geometric distortions are evaluated by linear measurements of the TG18-QC test pattern, which should render distortion coefficients less than 2%/5% for primary/secondary displays, respectively. Reflection measurements include specular and diffuse reflection coefficients from which the maximum allowable ambient lighting is determined such that contrast degradation due to display reflection remains below a 20% limit and the level of ambient luminance (L amb ) does not unduly compromise luminance ratio (LR) and contrast at low luminance levels. Luminance evaluation relies on visual assessment of low contrast features in the TG18-CT and TG18-MP test patterns, or quantitative measurements at 18 distinct luminance levels of the TG18-LN test patterns. The major acceptable criteria for primary/secondary displays are maximum luminance of greater than 170/100 cd/m 2 , LR of greater than 250/100, and contrast conformance to that of the grayscale standard display function (GSDF) of better than 10%/20%, respectively. The angular response is tested to

Executions in The Bahamas

Directory of Open Access Journals (Sweden)

Lofquist, William Steele

2010-01-01

Full Text Available The stories of those who have been executed in the Bahamas are heretofore untold. In telling these stories and in linking them to the changing course of Bahamian history, the present research adds an important dimension to our understanding of Bahamian history and politics. The major theme of this effort is that the changing practice of the death penalty is much more than a consequence of changes in crime. The use of the death penalty parallels the changing interests of colonial rulers, the changing practice of slavery, and the changing role of the Bahamas in colonial and regional affairs. Four distinctive eras of death penalty practice can be identified: (1 the slave era, where executions and commutations were used liberally and with a clear racial patterning; (2 a long era of stable colonialism, a period of marginalization and few executions; (3 an era of unstable colonialism characterized by intensive and efficient use of the death penalty; and (4 the current independence era of high murder rates and equally high impediments to the use of executions.

How Do South Korean Female Executives' Definitions of Career Success Differ from Those of Male Executives?

Science.gov (United States)

Cho, Yonjoo; Park, Jiwon; Han, Soo Jeoung; Ju, Boreum; You, Jieun; Ju, Ahreum; Park, Chan Kyun; Park, Hye Young

2017-01-01

Purpose: The purpose of this study was to compare South Korean female executives' definitions of career success with those of male executives, identify their career development strategies for success and provide implications for research and practice. Two research questions guiding our inquiry included: How do female executives' definitions of…

Canadian Thoracic Society 2012 Guideline Update: Diagnosis and Management of Asthma in Preschoolers, Children and Adults: Executive Summary

Directory of Open Access Journals (Sweden)

M Diane Lougheed

2012-01-01

Full Text Available BACKGROUND: In 2010, the Canadian Thoracic Society (CTS published a Consensus Summary for the diagnosis and management of asthma in children six years of age and older, and adults, including an updated Asthma Management Continuum. The CTS Asthma Clinical Assembly subsequently began a formal clinical practice guideline update process, focusing, in this first iteration, on topics of controversy and/or gaps in the previous guidelines.

GCFR demonstration plant: conceptual design and status report. Briefing document and executive summary

International Nuclear Information System (INIS)

1980-12-01

Helium Breeder Associates (HBA), a non-profit corporation, has been the program manager and technical integrator of the Gas-Cooled Fast Reactor (GCFR) development effort since 1977. When DOE discontinued support of the GCFR in 1980, the HBA members undertook the task of providing for an orderly termination and documentation of the program. HBA does not agree with the government's rational for withdrawing support for this promising technology and has directed its termination and documentation toward preserving the current state of its development. Toward that end, HBA has compiled a report of which this is a brief summary covering the conceptual design of the demonstration plant and status of the program as of the end of 1980. All the work in design, development, safety, and licensing which has been done to date, both in this country and in Europe, has given positive results and the prognosis for ultimately achieving the potential advantages of the GCFR is excellent. The report is intended to provide the reader with the design considerations that were current at the time of program termination. The report could be useful in restarting the program in the future by establishing the basis of the completed conceptual design and indicating a logical path for new design and development

Executive summary for the Weldon Spring Site Environmental Report for calendar year 1991

International Nuclear Information System (INIS)

1992-07-01

This report is the sixth in a series of annual reports produced by the Weldon Spring Site Remedial Action Project (WSSRAP) since 1986. It reports the results of a comprehensive, year-round program to monitor the impact of the Weldon Spring site (WSS) on the surrounding region's groundwater and surface waters; air quality; vegetation and wildlife; and, through these multiple pathways, the potential for exposure to receptor human populations. Information is also presented on the environmental monitoring quality assurance program, waste management activities, audits and reviews, and special environmental studies. Data are included for both the Weldon Spring Chemical Plant and raffinate pits and the Weldon Spring Quarry. Based on the consistent exercise of quality assurance in both standard operating procedures and quality control sample collection, the WSSRAP asserts that the data presented in the WSS Environmental Report for Calendar Year 1991 accurately reflect the environmental conditions monitored at the WSS. This report presents narratives, summaries, and conclusions on environmental monitoring at the WSS and surrounding vicinity properties for the entire 1991 monitoring year. During 1991 the WSSRAP also published quarterly data reports, wherein all routine monitoring data were tabulated and presented quarterly to allow the public to review the data in a timely fashion prior to issuance of the annual report

Autism Spectrum Disorder and intact executive functioning.

Science.gov (United States)

Ferrara, R; Ansermet, F; Massoni, F; Petrone, L; Onofri, E; Ricci, P; Archer, T; Ricci, S

2016-01-01

Earliest notions concerning autism (Autism Spectrum Disorders, ASD) describe the disturbance in executive functioning. Despite altered definition, executive functioning, expressed as higher cognitive skills required complex behaviors linked to the prefrontal cortex, are defective in autism. Specific difficulties in children presenting autism or verbal disabilities at executive functioning levels have been identified. Nevertheless, the developmental deficit of executive functioning in autism is highly diversified with huge individual variation and may even be absent. The aim of the present study to examine the current standing of intact executive functioning intact in ASD. Analysis of ASD populations, whether high-functioning, Asperger's or autism Broad Phenotype, studied over a range of executive functions including response inhibition, planning, cognitive flexibility, cognitive inhibition, and alerting networks indicates an absence of damage/impairment compared to the typically-developed normal control subjects. These findings of intact executive functioning in ASD subjects provide a strong foundation on which to construct applications for growth environments and the rehabilitation of autistic subjects.

Radon Gas in Ireland Joint Position Statement by the Radiological Protection Institute of Ireland and the Health Service Executive

International Nuclear Information System (INIS)

Part, A.M.; Colgan, P.A.; Fenton, D.; Kelly, I.; Long, S.; O'Mahony, M.; Pollard, D.

2010-04-01

This position statement is written by the Health Service Executive and the Radiological Protection Institute of Ireland with a view to forming and influencing policy in this area. It provides a summary of the health risks associated with radon exposure in Ireland and the steps that can be taken to reduce those risks. It outlines suggested ongoing work to reduce both the population dose from radon and the individual dose to those most at risk and considers future work needed to improve national policy to achieve these objectives

EMI Execution Service (EMI-ES) Specification

CERN Document Server

Schuller, B

2010-01-01

This document provides the interface specification, including related data models such as state model, activity description, resource and activity information, of an execution service, matching the needs of the EMI production middleware stack composed of ARC, gLite and UNICORE components. This service therefore is referred to as the EMI Execution Service (or “ES” for short). This document is a continuation of the work previously know as the GENEVA, then AGU (“ARC, gLite UNICORE”), then PGI execution service. As a starting point, the v0.42 of the “PGI Execution Service Specification” (doc15839) was used.

Tank waste remediation system retrieval and disposal mission initial updated baseline summary

International Nuclear Information System (INIS)

Swita, W.R.

1998-01-01

This document provides a summary of the Tank Waste Remediation System (TWRS) Retrieval and Disposal Mission Initial Updated Baseline (scope, schedule, and cost), developed to demonstrate Readiness-to-Proceed (RTP) in support of the TWRS Phase 1B mission. This Updated Baseline is the proposed TWRS plan to execute and measure the mission work scope. This document and other supporting data demonstrate that the TWRS Project Hanford Management Contract (PHMC) team is prepared to fully support Phase 1B by executing the following scope, schedule, and cost baseline activities: Deliver the specified initial low-activity waste (LAW) and high-level waste (HLW) feed batches in a consistent, safe, and reliable manner to support private contractors' operations starting in June 2002; Deliver specified subsequent LAW and HLW feed batches during Phase 1B in a consistent, safe, and reliable manner; Provide for the interim storage of immobilized HLW (IHLW) products and the disposal of immobilized LAW (ILAW) products generated by the private contractors; Provide for disposal of byproduct wastes generated by the private contractors; and Provide the infrastructure to support construction and operations of the private contractors' facilities

Executive summary: The health and fitness benefits of regular participation in small-sided football games

DEFF Research Database (Denmark)

Krustrup, Peter; Dvorak, J.; Junge, A.

2010-01-01

The present special issue of Scandinavian Journal of Medicine & Science in Sports deals with health and fitness benefits of regular participation in small-sided football games. One review article and 13 original articles were the result of a 2-year multi-center study in Copenhagen and Zurich...... and include studies of different age groups analyzed from a physiological, medical, social and psychological perspective. The main groups investigated were middle-aged, former untrained, healthy men and women who were followed for up to 16 months. In addition, elderly, children and hypertensive patients were...... studied. A summary and interpretations of the main findings divided into an analysis of the physical demands during training of various groups and the effect of a period of training on performance, muscle adaptations and health profile follow. In addition, social and psychological effects on participation...

Disciplining and Screening Top Executives

NARCIS (Netherlands)

S. Dominguez Martinez (Silvia); O.H. Swank (Otto); B. Visser (Bauke)

2006-01-01

textabstractBoards of directors face the twin task of disciplining and screening executives. To perform these tasks directors do not have detailed information about executives' behaviour, and only infrequently have information about the success or failure of initiated strategies, reorganizations,

The Undereducated American. Executive Summary

Science.gov (United States)

Carnavale, Anthony P.; Rose, Stephen J.

2011-01-01

The United States has been underproducing college-going workers since 1980. Supply has failed to keep pace with growing demand, and as a result, income inequality has grown precipitously. From 1915 to 1980, supply grew in tandem with demand. But, starting in 1990, the share of college-educated young people in the workforce rose very slowly. If the…

Constellation Lessons Learned Executive Summary

Science.gov (United States)

Thomas, L. Dale; Neubek, Deb

2011-01-01

This slide presentation reviews the lessons learned from the Constellation Program (CxP) and identified several factors that contributed to the inability of the CxP to meet the cost and schedule commitments. The review includes a significant section on the context in which the CxP operated since new programs are likely to experience the same constraints.

Executive summary of phase 2

International Nuclear Information System (INIS)

1989-02-01

The second phase of the Stripa project included the continued development of methods and techniques for repository site investigations. The crosshole investigations demonstrated that it is possible to characterize fractures in crystralline rock with a reliability and realism not obtained before. At the investigated site at Stripa, it was shown that groundwater flow is concentrated within a few major fractures that were idenfified by geophysical methods. The work at Stripa has shown that it is possible to collect and analyze data that enable one to determine the type of distribution and its parameters for each of the essential geometrical and hydraulic properties of the fracture system, and hence compare one site with another as part of experience builing in safety assessment studies. The migration experiment demonstrated that the groundwater flow could be very unevenly distributed in the rock. The hydrogeochemical investigations at Stripa also indicated that a new type of solute source must be considered - fluid inclusions in the host rock. The age of the solutes may be entirely different from the age of the groundwater. Sealing and redirection of the groundwater flow away from man made openings in the rock was tested at Stripa and found to be feasible as shown in the various plugging and sealing experiments. The use of Na bentonite in the form of suitably shaped blocks of highly compacted powder has been found to be very practical for sealing off boreholes, shafts and tunnels in repositories

Executive Summary-Final Technical Report

Energy Technology Data Exchange (ETDEWEB)

Anderson, R. R.

2004-02-18

The primary goal since inception of this DOE grant award in 1991 to Wellman Laboratories of Photomedicine, Harvard Medical School, Massachusetts General Hospital, has been to support competitive research fellowships aimed at solving important medical problems, contributing significant new knowledge and/or technology. This approach was taken according to the original intent of the DOE program, to foster excellent centers for research and development of lasers and optics in medicine. Laser photomedicine broadly encompasses optical therapy and optical diagnostics, within any organ system. The research supported clearly reflects this breadth and depth.

Nurse executive transformational leadership found in participative organizations.

Science.gov (United States)

Dunham-Taylor, J

2000-05-01

The study examined a national sample of 396 randomly selected hospital nurse executives to explore transformational leadership, stage of power, and organizational climate. Results from a few nurse executive studies have found nurse executives were transformational leaders. As executives were more transformational, they achieved better staff satisfaction and higher work group effectiveness. This study integrates Bass' transformational leadership model with Hagberg's power stage theory and Likert's organizational climate theory. Nurse executives (396) and staff reporting to them (1,115) rated the nurse executives' leadership style, staff extra effort, staff satisfaction, and work group effectiveness using Bass and Avolio's Multifactor Leadership Questionnaire. Executives' bosses (360) rated executive work group effectiveness. Executives completed Hagberg's Personal Power Profile and ranked their organizational climate using Likert's Profile of Organizational Characteristics. Nurse executives used transformational leadership fairly often; achieved fairly satisfied staff levels; were very effective according to bosses; were most likely at stage 3 (power by achievement) or stage 4 (power by reflection); and rated their hospital as a Likert System 3 Consultative Organization. Staff satisfaction and work group effectiveness decreased as nurse executives were more transactional. Higher transformational scores tended to occur with higher educational degrees and within more participative organizations. Transformational qualities can be enhanced by further education, by achieving higher power stages, and by being within more participative organizations.

A simple hypothesis of executive function

Directory of Open Access Journals (Sweden)

Bruno eKopp

2012-06-01

Full Text Available Executive function is traditionally conceptualized as a set of abilities required to guide behavior toward goals. Here, an integrated theoretical framework for executive function is developed which has its roots in the notion of hierarchical mental models. Further following Duncan (2010a,b, executive function is construed as a hierarchical recursive system of test-operation-test-exit units (Miller, Galanter, and Pribram, 1960. Importantly, it is shown that this framework can be used to model the main regional prefrontal syndromes, which are characterized by apathetic, disinhibited and dysexecutive cognition and behavior, respectively. Implications of these considerations for the neuropsychological assessment of executive function are discussed.

Workshop on using natural language processing applications for enhancing clinical decision making: an executive summary.

Science.gov (United States)

Pai, Vinay M; Rodgers, Mary; Conroy, Richard; Luo, James; Zhou, Ruixia; Seto, Belinda

2014-02-01

In April 2012, the National Institutes of Health organized a two-day workshop entitled 'Natural Language Processing: State of the Art, Future Directions and Applications for Enhancing Clinical Decision-Making' (NLP-CDS). This report is a summary of the discussions during the second day of the workshop. Collectively, the workshop presenters and participants emphasized the need for unstructured clinical notes to be included in the decision making workflow and the need for individualized longitudinal data tracking. The workshop also discussed the need to: (1) combine evidence-based literature and patient records with machine-learning and prediction models; (2) provide trusted and reproducible clinical advice; (3) prioritize evidence and test results; and (4) engage healthcare professionals, caregivers, and patients. The overall consensus of the NLP-CDS workshop was that there are promising opportunities for NLP and CDS to deliver cognitive support for healthcare professionals, caregivers, and patients.

Executive Functioning Heterogeneity in Pediatric ADHD.

Science.gov (United States)

Kofler, Michael J; Irwin, Lauren N; Soto, Elia F; Groves, Nicole B; Harmon, Sherelle L; Sarver, Dustin E

2018-04-28

Neurocognitive heterogeneity is increasingly recognized as a valid phenomenon in ADHD, with most estimates suggesting that executive dysfunction is present in only about 33%-50% of these children. However, recent critiques question the veracity of these estimates because our understanding of executive functioning in ADHD is based, in large part, on data from single tasks developed to detect gross neurological impairment rather than the specific executive processes hypothesized to underlie the ADHD phenotype. The current study is the first to comprehensively assess heterogeneity in all three primary executive functions in ADHD using a criterion battery that includes multiple tests per construct (working memory, inhibitory control, set shifting). Children ages 8-13 (M = 10.37, SD = 1.39) with and without ADHD (N = 136; 64 girls; 62% Caucasian/Non-Hispanic) completed a counterbalanced series of executive function tests. Accounting for task unreliability, results indicated significantly improved sensitivity and specificity relative to prior estimates, with 89% of children with ADHD demonstrating objectively-defined impairment on at least one executive function (62% impaired working memory, 27% impaired inhibitory control, 38% impaired set shifting; 54% impaired on one executive function, 35% impaired on two or all three executive functions). Children with working memory deficits showed higher parent- and teacher-reported ADHD inattentive and hyperactive/impulsive symptoms (BF 10  = 5.23 × 10 4 ), and were slightly younger (BF 10  = 11.35) than children without working memory deficits. Children with vs. without set shifting or inhibitory control deficits did not differ on ADHD symptoms, age, gender, IQ, SES, or medication status. Taken together, these findings confirm that ADHD is characterized by neurocognitive heterogeneity, while suggesting that contemporary, cognitively-informed criteria may provide improved precision for identifying a

Building the blocks of executive functioning: differentiating early developing processes contributing to executive functioning skills

NARCIS (Netherlands)

Mandell, D.J.; Ward, S.E.

2011-01-01

The neural processes that underlie executive function begin to develop in infancy. However, it is unclear how the behavior manifested by these processes are related or if they can be differentiated early in development. This study seeks to examine early emerging executive functioning skills in

The Impact of Hedge Fund Activism on Target Firm Performance, Executive Compensation and Executive Wealth

Directory of Open Access Journals (Sweden)

Andrew Carrothers

2017-10-01

Full Text Available This paper examines the relationship between hedge fund activism and target firm performance, executive compensation, and executive wealth. It introduces a theoretical framework that describes the activism process as a sequence of discrete decisions. The methodology uses regression analysis on a matched sample based on firm size, industry, and market-to-book ratio. All regressions control for industry and year fixed effects. Schedule 13D Securities and Exchange Commission (SEC filings are the source for the statistical sample of hedge fund target firms. I supplement that data with target firm financial, operating, and share price information from the CRSP-COMPUSTAT merged database. Activist hedge funds target undervalued or underperforming firms with high profitability and cash flows. They do not avoid firms with powerful CEOs. Leverage, executive compensation, pay for performance and CEO turnover increase at target firms after the arrival of the activist hedge fund. Target firm executives’ wealth is more sensitive to changes in share price after hedge fund activism events suggesting that the executive team experiences changes to their compensation structure that provides incentive to take action to improve returns to shareholders. The top executives reap rewards for increasing firm value but not for increased risk taking.

General Public Space Travel and Tourism. Volume 1; Executive Summary

Science.gov (United States)

ONeil, Daniel (Compiler); Bekey, Ivan; Mankins, John; Rogers, Thomas F.; Stallmer, Eric W.

1998-01-01

risk. A two-year cooperative Space Act agreement study has been conducted by our National Aeronautics and Space Administration and the Space Transportation Association. It was conducted by NASA and STA study leaders drawing upon the competence, experience and hard-nosed imagination of a national Steering Group and scores of attendees at a multi-day Workshop. The study has involved scores of professionals and business people from various areas: astronauts; space booster technology and operations professionals; a hotel architect and a hotel operator; an airline planner; insurance underwriters; space sickness experts; space theme park designers; space and travel and tourism association and business executives; a space-related financier; university tourism and space policy experts; present and former space-responsible government officials; space entrepreneurs; space writers; This study concludes that serious national attention should now be given to activities that would enable the expansion of today's terrestrial space tourism businesses, and the creation of in-space travel and tourism businesses. Indeed, it concludes that, in time, it should become a very important part of our Country's overall commercial and civil space business-program structure.

Executable Architecture Research at Old Dominion University

Science.gov (United States)

Tolk, Andreas; Shuman, Edwin A.; Garcia, Johnny J.

2011-01-01

Executable Architectures allow the evaluation of system architectures not only regarding their static, but also their dynamic behavior. However, the systems engineering community do not agree on a common formal specification of executable architectures. To close this gap and identify necessary elements of an executable architecture, a modeling language, and a modeling formalism is topic of ongoing PhD research. In addition, systems are generally defined and applied in an operational context to provide capabilities and enable missions. To maximize the benefits of executable architectures, a second PhD effort introduces the idea of creating an executable context in addition to the executable architecture. The results move the validation of architectures from the current information domain into the knowledge domain and improve the reliability of such validation efforts. The paper presents research and results of both doctoral research efforts and puts them into a common context of state-of-the-art of systems engineering methods supporting more agility.

Executive function, episodic memory, and Medicare expenditures.

Science.gov (United States)

Bender, Alex C; Austin, Andrea M; Grodstein, Francine; Bynum, Julie P W

2017-07-01

We examined the relationship between health care expenditures and cognition, focusing on differences across cognitive systems defined by global cognition, executive function, or episodic memory. We used linear regression models to compare annual health expenditures by cognitive status in 8125 Nurses' Health Study participants who completed a cognitive battery and were enrolled in Medicare parts A and B. Adjusting for demographics and comorbidity, executive impairment was associated with higher total annual expenditures of $1488 per person (P episodic memory impairment was found. Expenditures exhibited a linear relationship with executive function, but not episodic memory ($584 higher for every 1 standard deviation decrement in executive function; P < .01). Impairment in executive function is specifically and linearly associated with higher health care expenditures. Focusing on management strategies that address early losses in executive function may be effective in reducing costly services. Copyright © 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Independence and executive remuneration for supervisory board members and non-executive directors

Directory of Open Access Journals (Sweden)

Hana Horak

2011-01-01

Full Text Available In this paper, the author analyses the issues of independence and rewarding members of supervisory boards and non-executive directors in administrative boards. The question of independence was developed as one of the fundamental issues of corporative administration. Members of these organs of society should have the appropriate qualifications, specific knowledge and skills in order to reasonably and impartially weigh up social business and reach decisions in the best interests of society, its members and other interest holders. So that they can act in accordance with this, the presumption is that they are independent. Recently, after financial crises, it is precisely the independence of supervisory members, that is, non-executive directors, which is considered to be the foundation of the fight against the opportunism of administration and main shareholders. The authors analyse the Recommendations on Independence and Executive Remuneration for members of supervisory and administrative boards of the European Union, together with their implementation in Croatian law and practice.

Bleeding risk assessment and management in atrial fibrillation patients. Executive Summary of a Position Document from the European Heart Rhythm Association [EHRA], endorsed by the European Society of Cardiology [ESC] Working Group on Thrombosis.

Science.gov (United States)

Lip, Gregory Y H; Andreotti, Felicita; Fauchier, Laurent; Huber, Kurt; Hylek, Elaine; Knight, Eve; Lane, Deirdre; Levi, Marcel; Marín, Francisco; Palareti, Gualtiero; Kirchhof, Paulus

2011-12-01

In this executive summary of a Consensus Document from the European Heart Rhythm Association, endorsed by the European Society of Cardiology Working Group on Thrombosis, we comprehensively review the published evidence and propose a consensus on bleeding risk assessments in atrial fibrillation (AF) patients. The main aim of the document was to summarise 'best practice' in dealing with bleeding risk in AF patients when approaching antithrombotic therapy, by addressing the epidemiology and size of the problem, and review established bleeding risk factors. We also summarise definitions of bleeding in the published literature. Patient values and preferences balancing the risk of bleeding against thromboembolism as well as the prognostic implications of bleeding are reviewed. We also provide an overview of published bleeding risk stratification and bleeding risk schema. Brief discussion of special situations (e.g. periablation, peri-devices such as implantable cardioverter defibrillators [ICD] or pacemakers, presentation with acute coronary syndromes and/or requiring percutanous coronary interventions/stents and bridging therapy) is made, as well as a discussion of the prevention of bleeds and managing bleeding complications. Finally, this document puts forwards consensus statements that may help to define evidence gaps and assist in everyday clinical practice.

The contribution of executive control to semantic cognition: Convergent evidence from semantic aphasia and executive dysfunction.

Science.gov (United States)

Thompson, Hannah E; Almaghyuli, Azizah; Noonan, Krist A; Barak, Ohr; Lambon Ralph, Matthew A; Jefferies, Elizabeth

2018-01-03

Semantic cognition, as described by the controlled semantic cognition (CSC) framework (Rogers et al., , Neuropsychologia, 76, 220), involves two key components: activation of coherent, generalizable concepts within a heteromodal 'hub' in combination with modality-specific features (spokes), and a constraining mechanism that manipulates and gates this knowledge to generate time- and task-appropriate behaviour. Executive-semantic goal representations, largely supported by executive regions such as frontal and parietal cortex, are thought to allow the generation of non-dominant aspects of knowledge when these are appropriate for the task or context. Semantic aphasia (SA) patients have executive-semantic deficits, and these are correlated with general executive impairment. If the CSC proposal is correct, patients with executive impairment should not only exhibit impaired semantic cognition, but should also show characteristics that align with those observed in SA. This possibility remains largely untested, as patients selected on the basis that they show executive impairment (i.e., with 'dysexecutive syndrome') have not been extensively tested on tasks tapping semantic control and have not been previously compared with SA cases. We explored conceptual processing in 12 patients showing symptoms consistent with dysexecutive syndrome (DYS) and 24 SA patients, using a range of multimodal semantic assessments which manipulated control demands. Patients with executive impairments, despite not being selected to show semantic impairments, nevertheless showed parallel patterns to SA cases. They showed strong effects of distractor strength, cues and miscues, and probe-target distance, plus minimal effects of word frequency on comprehension (unlike semantic dementia patients with degradation of conceptual knowledge). This supports a component process account of semantic cognition in which retrieval is shaped by control processes, and confirms that deficits in SA patients reflect

Culture, executive function, and social understanding.

Science.gov (United States)

Lewis, Charlie; Koyasu, Masuo; Oh, Seungmi; Ogawa, Ayako; Short, Benjamin; Huang, Zhao

2009-01-01

Much of the evidence from the West has shown links between children's developing self-control (executive function), their social experiences, and their social understanding (Carpendale & Lewis, 2006, chapters 5 and 6), across a range of cultures including China. This chapter describes four studies conducted in three Oriental cultures, suggesting that the relationships among social interaction, executive function, and social understanding are different in these cultures, implying that social and executive skills are underpinned by key cultural processes.

Developmental Changes in Executive Functioning

Science.gov (United States)

Lee, Kerry; Bull, Rebecca; Ho, Ringo M. H.

2013-01-01

Although early studies of executive functioning in children supported Miyake et al.'s (2000) three-factor model, more recent findings supported a variety of undifferentiated or two-factor structures. Using a cohort-sequential design, this study examined whether there were age-related differences in the structure of executive functioning among…

Research Summaries

Science.gov (United States)

Brock, Stephen E., Ed.

2011-01-01

This article presents summaries of three articles relevant to school crisis response: (1) "Factors Contributing to Posttraumatic Growth," summarized by Steve DeBlois; (2) "Psychological Debriefing in Cross-Cultural Contexts" (Stacey Rice); and (3) "Brain Abnormalities in PTSD" (Sunny Windingstad). The first summary reports the findings of a…

ARC Code TI: IPG Execution Service

Data.gov (United States)

National Aeronautics and Space Administration — The Execution Service allows users to submit, monitor, and cancel complex jobs. Each job consists of a set of tasks that perform actions such as executing...

Questionnaire-based assessment of executive functioning: Psychometrics.

Science.gov (United States)

Castellanos, Irina; Kronenberger, William G; Pisoni, David B

2018-01-01

The psychometric properties of the Learning, Executive, and Attention Functioning (LEAF) scale were investigated in an outpatient clinical pediatric sample. As a part of clinical testing, the LEAF scale, which broadly measures neuropsychological abilities related to executive functioning and learning, was administered to parents of 118 children and adolescents referred for psychological testing at a pediatric psychology clinic; 85 teachers also completed LEAF scales to assess reliability across different raters and settings. Scores on neuropsychological tests of executive functioning and academic achievement were abstracted from charts. Psychometric analyses of the LEAF scale demonstrated satisfactory internal consistency, parent-teacher inter-rater reliability in the small to large effect size range, and test-retest reliability in the large effect size range, similar to values for other executive functioning checklists. Correlations between corresponding subscales on the LEAF and other behavior checklists were large, while most correlations with neuropsychological tests of executive functioning and achievement were significant but in the small to medium range. Results support the utility of the LEAF as a reliable and valid questionnaire-based assessment of delays and disturbances in executive functioning and learning. Applications and advantages of the LEAF and other questionnaire measures of executive functioning in clinical neuropsychology settings are discussed.

EXECUTIVE FUNCTIONING IN SCHIZOPHRENIA

Directory of Open Access Journals (Sweden)

Gricel eOrellana

2013-06-01

Full Text Available The executive function (EF is a set of abilities, which allows us to invoke voluntary control of our behavioral responses. These functions enable human beings to develop and carry out plans, make up analogies, obey social rules, solve problems, adapt to unexpected circumstances, do many tasks simultaneously and locate episodes in time and place. EF includes divided attention and sustained attention, working memory, set-shifting, flexibility, planning and the regulation of goal directed behavior and can be defined as a brain function underlying the human faculty to act or think not only in reaction to external events but also in relation with internal goals and states. EF is mostly associated with dorsolateral prefrontal cortex (PFC. Besides EF, PFC is involved in self-regulation of behavior, i.e. the ability to regulate behavior according to internal goals and constraints, particularly in less structured situations. Self-regulation of behavior is subtended by ventral medial /orbital PFC. Impairment of EF is one of the most commonly observed deficits in schizophrenia through the various disease stages. Impairment in tasks measuring conceptualization, planning, cognitive flexibility, verbal fluency, ability to solve complex problems and working memory occur in schizophrenia. Disorders detected by executive tests are consistent with evidence from functional neuroimaging, which have shown PFC dysfunction in patients while performing these kinds of tasks. Schizophrenics also exhibit deficit in odor identifying, decision-making and self-regulation of behavior suggesting dysfunction of the orbital PFC. However, impairment in executive tests is explained by dysfunction of prefronto-striato-thalamic, prefronto-parietal and prefronto-temporal neural networks mainly. Disorders in executive functions may be considered central facts with respect to schizophrenia and it has been suggested that negative symptoms may be explained by that executive dysfunction.

Executive Competencies of Nurses within the Veterans Health Administration: Comparison of Current and Future Nurse Executive Views

National Research Council Canada - National Science Library

Sutto, Natalie B

2006-01-01

...). Using the Delphi method for executive decision-making, 144 current nurse executives, as well as 168 nurses identified for potential selection to this position, judged the relative importance of SKAs...

75 FR 28027 - Tobacco Products Scientific Advisory Committee; Notice of Meeting

Science.gov (United States)

2010-05-19

... effects of menthol, biomarkers of disease risk, marketing data, and population effects. Specific areas of.... Marketing strategies for various brands/subbrands of menthol cigarettes, including strategies targeted to particular demographic groups. 14. Marketing strategies for various brands/subbrands of menthol cigarettes...

Statistical Symbolic Execution with Informed Sampling

Science.gov (United States)

Filieri, Antonio; Pasareanu, Corina S.; Visser, Willem; Geldenhuys, Jaco

2014-01-01

Symbolic execution techniques have been proposed recently for the probabilistic analysis of programs. These techniques seek to quantify the likelihood of reaching program events of interest, e.g., assert violations. They have many promising applications but have scalability issues due to high computational demand. To address this challenge, we propose a statistical symbolic execution technique that performs Monte Carlo sampling of the symbolic program paths and uses the obtained information for Bayesian estimation and hypothesis testing with respect to the probability of reaching the target events. To speed up the convergence of the statistical analysis, we propose Informed Sampling, an iterative symbolic execution that first explores the paths that have high statistical significance, prunes them from the state space and guides the execution towards less likely paths. The technique combines Bayesian estimation with a partial exact analysis for the pruned paths leading to provably improved convergence of the statistical analysis. We have implemented statistical symbolic execution with in- formed sampling in the Symbolic PathFinder tool. We show experimentally that the informed sampling obtains more precise results and converges faster than a purely statistical analysis and may also be more efficient than an exact symbolic analysis. When the latter does not terminate symbolic execution with informed sampling can give meaningful results under the same time and memory limits.

Toward synthesizing executable models in biology.

Science.gov (United States)

Fisher, Jasmin; Piterman, Nir; Bodik, Rastislav

2014-01-01

Over the last decade, executable models of biological behaviors have repeatedly provided new scientific discoveries, uncovered novel insights, and directed new experimental avenues. These models are computer programs whose execution mechanistically simulates aspects of the cell's behaviors. If the observed behavior of the program agrees with the observed biological behavior, then the program explains the phenomena. This approach has proven beneficial for gaining new biological insights and directing new experimental avenues. One advantage of this approach is that techniques for analysis of computer programs can be applied to the analysis of executable models. For example, one can confirm that a model agrees with experiments for all possible executions of the model (corresponding to all environmental conditions), even if there are a huge number of executions. Various formal methods have been adapted for this context, for example, model checking or symbolic analysis of state spaces. To avoid manual construction of executable models, one can apply synthesis, a method to produce programs automatically from high-level specifications. In the context of biological modeling, synthesis would correspond to extracting executable models from experimental data. We survey recent results about the usage of the techniques underlying synthesis of computer programs for the inference of biological models from experimental data. We describe synthesis of biological models from curated mutation experiment data, inferring network connectivity models from phosphoproteomic data, and synthesis of Boolean networks from gene expression data. While much work has been done on automated analysis of similar datasets using machine learning and artificial intelligence, using synthesis techniques provides new opportunities such as efficient computation of disambiguating experiments, as well as the ability to produce different kinds of models automatically from biological data.

EMI Execution Service Specification 1.0

CERN Document Server

Schuller, B. (JUELICH); Smirnova, O (Lund University); Konstantinov, A. (Oslo University); Skou Andersen, M. (University of Copenhagen); Riedel, M. (JUELICH); Memon, A.S. (JUELICH); Memon, M.S. (JUELICH); Zangrando, L. (INFN); Sgaravatto, M. (INFN); Frizziero, E. (INFN)

2010-01-01

This document provides the interface specification, including related data models such as state model, activity description, resource and activity information, of an execution service, matching the needs of the EMI production middleware stack composed of ARC, gLite and UNICORE components. This service therefore is referred to as the EMI Execution Service (or “ES” for short). This document is a continuation of the work previously known as the GENEVA, then AGU (“ARC, gLite UNICORE”), then PGI execution service.

Final summary report of the Nordic Nuclear Safety Research Program 1998-2001; Sammanfattning av det nordiska forsknings-programmet for karnsakerhet

Energy Technology Data Exchange (ETDEWEB)

Bennerstedt, T. (ed.)

2002-11-01

The results of the 1998 - 2001 NKS program are presented in the form of executive summaries, highlighting the conclusions, recommendations and other findings and results of the six projects carried out during that period. The titles of the six projects are: Risk assessment and strategies for safety (NKS/SOS-1); Reactor safety (NKS/SOS-2); Radioactive waste (NKS/SOS-3); Nuclear Emergency preparedness (NKS/BOK-1); Radiological and environmental consequences (NKS/BOK-2); Nuclear threats from Nordic surroundings (NKS/SBA-1) (ln)

PERCEPTIONS OF EXECUTIVE PAYMENT ABUSE IN PUBLIC INSTITUTIONS

Directory of Open Access Journals (Sweden)

Tudor Pendiuc

2013-07-01

Full Text Available In the aftermath of the financial crisis, executive compensation abuse has been deeply criticized. Thus, the actuality of research is undeniable. The article highlights the importance of learning from other institutions’ past and present executive compensation abuse experiences by presenting the participants’ shared experiences (having to do with executive compensation abuse and by studying how participants perceive executive compensation abuse. The main objective of this research lies in exploring participants’ shared experiences concerning executive compensation abuse, as well as their perceptions, discrepancies and unsolved questions – presented within an ample, interconnected qualitative and quantitative methodological approach. A sample of 20 individuals was chosen for the triangulation method. From the resultant triangulation six new themes derive from the interview/questionnaire questions specifically referring to executive payment abuse namely: (a ethics means distinguishing between right and wrong, (b perspectives of ethical behaviour, (c types of executive payment abuse, (d the participant’s perceptions of institution and colleagues.

An Embodied Account of Early Executive-Function Development

Science.gov (United States)

Gottwald, Janna M.; Achermann, Sheila; Marciszko, Carin; Lindskog, Marcus; Gredebäck, Gustaf

2016-01-01

The importance of executive functioning for later life outcomes, along with its potential to be positively affected by intervention programs, motivates the need to find early markers of executive functioning. In this study, 18-month-olds performed three executive-function tasks—involving simple inhibition, working memory, and more complex inhibition—and a motion-capture task assessing prospective motor control during reaching. We demonstrated that prospective motor control, as measured by the peak velocity of the first movement unit, is related to infants’ performance on simple-inhibition and working memory tasks. The current study provides evidence that motor control and executive functioning are intertwined early in life, which suggests an embodied perspective on executive-functioning development. We argue that executive functions and prospective motor control develop from a common source and a single motive: to control action. This is the first demonstration that low-level movement planning is related to higher-order executive control early in life. PMID:27765900

Questionnaire-based assessment of executive functioning: Case studies.

Science.gov (United States)

Kronenberger, William G; Castellanos, Irina; Pisoni, David B

2018-01-01

Delays in the development of executive functioning skills are frequently observed in pediatric neuropsychology populations and can have a broad and significant impact on quality of life. As a result, assessment of executive functioning is often relevant for the development of formulations and recommendations in pediatric neuropsychology clinical work. Questionnaire-based measures of executive functioning behaviors in everyday life have unique advantages and complement traditional neuropsychological measures of executive functioning. Two case studies of children with spina bifida are presented to illustrate the clinical use of a new questionnaire measure of executive and learning-related functioning, the Learning, Executive, and Attention Functioning Scale (LEAF). The LEAF emphasizes clinical utility in assessment by incorporating four characteristics: brevity in administration, breadth of additional relevant content, efficiency of scoring and interpretation, and ease of availability for use. LEAF results were consistent with another executive functioning checklist in documenting everyday behavior problems related to working memory, planning, and organization while offering additional breadth of assessment of domains such as attention, processing speed, and novel problem-solving. These case study results demonstrate the clinical utility of questionnaire-based measurement of executive functioning in pediatric neuropsychology and provide a new measure for accomplishing this goal.

An empirical analysis of executive behaviour with hospital executive information systems in Taiwan.

Science.gov (United States)

Huang, Wei-Min

2013-01-01

Existing health information systems largely only support the daily operations of a medical centre, and are unable to generate the information required by executives for decision-making. Building on past research concerning information retrieval behaviour and learning through mental models, this study examines the use of information systems by hospital executives in medical centres. It uses a structural equation model to help find ways hospital executives might use information systems more effectively. The results show that computer self-efficacy directly affects the maintenance of mental models, and that system characteristics directly impact learning styles and information retrieval behaviour. Other results include the significant impact of perceived environmental uncertainty on scan searches; information retrieval behaviour and focused searches on mental models and perceived efficiency; scan searches on mental model building; learning styles and model building on perceived efficiency; and finally the impact of mental model maintenance on perceived efficiency and effectiveness.

Vectorization vs. compilation in query execution

NARCIS (Netherlands)

J. Sompolski (Juliusz); M. Zukowski (Marcin); P.A. Boncz (Peter)

2011-01-01

textabstractCompiling database queries into executable (sub-) programs provides substantial benefits comparing to traditional interpreted execution. Many of these benefits, such as reduced interpretation overhead, better instruction code locality, and providing opportunities to use SIMD

Executive dysfunction, brain aging, and political leadership.

Science.gov (United States)

Fisher, Mark; Franklin, David L; Post, Jerrold M

2014-01-01

Decision-making is an essential component of executive function, and a critical skill of political leadership. Neuroanatomic localization studies have established the prefrontal cortex as the critical brain site for executive function. In addition to the prefrontal cortex, white matter tracts as well as subcortical brain structures are crucial for optimal executive function. Executive function shows a significant decline beginning at age 60, and this is associated with age-related atrophy of prefrontal cortex, cerebral white matter disease, and cerebral microbleeds. Notably, age-related decline in executive function appears to be a relatively selective cognitive deterioration, generally sparing language and memory function. While an individual may appear to be functioning normally with regard to relatively obvious cognitive functions such as language and memory, that same individual may lack the capacity to integrate these cognitive functions to achieve normal decision-making. From a historical perspective, global decline in cognitive function of political leaders has been alternatively described as a catastrophic event, a slowly progressive deterioration, or a relatively episodic phenomenon. Selective loss of executive function in political leaders is less appreciated, but increased utilization of highly sensitive brain imaging techniques will likely bring greater appreciation to this phenomenon. Former Israeli Prime Minister Ariel Sharon was an example of a political leader with a well-described neurodegenerative condition (cerebral amyloid angiopathy) that creates a neuropathological substrate for executive dysfunction. Based on the known neuroanatomical and neuropathological changes that occur with aging, we should probably assume that a significant proportion of political leaders over the age of 65 have impairment of executive function.

31 CFR 26.3 - Availability of Environmental Impact Assessment Summaries (EIA Summaries) and Environmental...

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Availability of Environmental Impact Assessment Summaries (EIA Summaries) and Environmental Impact Assessments (EIAs). 26.3 Section 26.3 Money and... DEVELOPMENT BANDS (MDBs) § 26.3 Availability of Environmental Impact Assessment Summaries (EIA Summaries) and...

39 CFR 211.3 - Executive orders and other executive pronouncements; circulars, bulletins, and other issuances of...

Science.gov (United States)

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Executive orders and other executive pronouncements; circulars, bulletins, and other issuances of the Office of Management and Budget. 211.3 Section 211.3 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION APPLICATION OF...

EXECUTIVE SUMMARY OF STATE DATA RELATED TO ABANDONED CENTRALIZED AND COMMERCIAL DRILLING-FLUID DISPOSAL SITES IN LOUISIANA, NEW MEXICO, OKLAHOMA, AND TEXAS

Energy Technology Data Exchange (ETDEWEB)

H. Seay Nance

2003-03-01

This 2003 Spring Semi-Annual Report contains a summary of the Final Technical Report being prepared for the Soil Remediation Requirements at Commercial and Centralized Drilling-Fluid Disposal (CCDD) Sites project funded by the United States Department of Energy under DOE Award No. DE-AC26-99BC15225. The summary describes (1) the objectives of the investigation, (2) a rationale and methodology of the investigation, (3) sources of data, assessment of data quality, and data availability, (4) examples of well documented centralized and commercial drilling-fluid disposal (CCDD) sites and other sites where drilling fluid was disposed of, and (5) examples of abandoned sites and measures undertaken for their assessment and remediation. The report also includes most of the figures, tables, and appendices that will be included in the final report.

Towards Synthesizing Executable Models in Biology

Directory of Open Access Journals (Sweden)

Jasmin eFisher

2014-12-01

Full Text Available Over the last decade, executable models of biological behaviors have repeatedly provided new scientific discoveries, uncovered novel insights, and directed new experimental avenues. These models are computer programs whose execution mechanistically simulates aspects of the cell’s behaviors. If the observed behavior of the program agrees with the observed biological behavior, then the program explains the phenomena. This approach has proven beneficial for gaining new biological insights and directing new experimental avenues. One advantage of this approach is that techniques for analysis of computer programs can be applied to the analysis of executable models. For example, one can confirm that a model agrees with experiments for all possible executions of the model (corresponding to all environmental conditions, even if there are a huge number of executions. Various formal methods have been adapted for this context, for example, model checking or symbolic analysis of state spaces. To avoid manual construction of executable models, one can apply synthesis, a method to produce programs automatically from high-level specifications. In the context of biological modelling, synthesis would correspond to extracting executable models from experimental data. We survey recent results about the usage of the techniques underlying synthesis of computer programs for the inference of biological models from experimental data. We describe synthesis of biological models from curated mutation experiment data, inferring network connectivity models from phosphoproteomic data, and synthesis of Boolean networks from gene expression data. While much work has been done on automated analysis of similar datasets using machine learning and artificial intelligence, using synthesis techniques provides new opportunities such as efficient computation of disambiguating experiments, as well as the ability to produce different kinds of models automatically from biological data.