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Sample records for mendelevium 250

  1. 48 CFR 1846.672 - Preparing DD Forms 250 and 250c.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Preparing DD Forms 250 and 250c. 1846.672 Section 1846.672 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... DD Forms 250 and 250c. ...

  2. 48 CFR 1846.673 - Distribution of DD Forms 250 and 250c.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Distribution of DD Forms... Reports 1846.673 Distribution of DD Forms 250 and 250c. (a) DD Forms 250 and 250c shall be distributed in accordance with installation procedures. (b) The contractor is responsible for distributing DD Forms 250 and...

  3. 21 CFR 250.250 - Hexachlorophene, as a component of drug and cosmetic products.

    Science.gov (United States)

    2010-04-01

    ... cosmetic products. 250.250 Section 250.250 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Requirements for Drugs and Cosmetics § 250.250 Hexachlorophene, as a component of drug and cosmetic products... cosmetic products has expanded widely in recent years. It is used in such products because of its...

  4. Levels of 250Cf populated in the decay of 250Bk

    International Nuclear Information System (INIS)

    Uecke, J.W.

    1975-06-01

    The nuclide 250 Bk undergoes β-decay with a half-life of 3.2 h to 13.1 y 250 Cf. A study is undertaken of the excited states in 250 Cf populated by 250 Bk decay which results from the α-decay of 276d 254 Es. The general features of published level schemes for these nuclei are consistent with predictions of the Nilsson and collective models; however, there remain many undiscovered transitions and ambiguous or uncertain level assignments. In an attempt to confirm predictions of current theoretical models which account for nuclear level assignments in this nucleus, these gamma transitions and their levels have been studied. Twenty-eight new γ-rays were determined. The decay of 250 Bk is investigated primarily by high resolution gamma-ray singles spectrometry and supported in part by two-parameter gamma-gamma coincidence spectrometry. The equipment, comprised of a Ge(HP) and a large volume Ge(Li) detector, a 4096-channel two-parameter analyzer, and a PDP-8/e computer system, permitted significant improvement in sensitivity and accuracy over previous investigations on this nucleus. (11 figures, 2 tables) (U.S.)

  5. 30 CFR 250.1000 - General requirements.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false General requirements. 250.1000 Section 250.1000... OPERATIONS IN THE OUTER CONTINENTAL SHELF Pipelines and Pipeline Rights-of-Way § 250.1000 General....1001, must meet the requirements in §§ 250.1000 through 250.1008. (2) A pipeline right-of-way grant...

  6. 30 CFR 250.1201 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Definitions. 250.1201 Section 250.1201 Mineral... Security § 250.1201 Definitions. Terms not defined in this section have the meanings given in the... hydrocarbons attributable to one or more platforms, leases, units, or wells, in relation to the total...

  7. 7 CFR 250.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Administration. 250.2 Section 250.2 Agriculture... TERRITORIES AND POSSESSIONS AND AREAS UNDER ITS JURISDICTION General § 250.2 Administration. (a) Delegation to FNS. Within the Department, FNS shall act on behalf of the Department in the administration of the...

  8. Chemical properties of mendelevium

    International Nuclear Information System (INIS)

    Hulet, E.K.

    1980-01-01

    The isotope 256 Md is nearly always employed for chemical studies of this element. This nuclide can be made by bombardment of fractions of a microgram of 254 Es with intense alpha-particle beams which will produce about 10 6 atoms of 256 Md with a half-life of 77 minutes. Even with the most intense ion beams and the largest available quantities of target isotope, about 10 6 atoms at a time is all the Md that can be produced for chemical studies. This lack of sufficient sample size coupled with the very short lifetimes of the few atoms produced has severly restricted the gathering and broadening of our knowledge concerning the properties of Md and the heavier elements. To illustrate, the literature contains a mere eleven references to the chemical studies of Md, and none of these deal with bulk properties associated with element found in solid phases. Some of these findings are: Md was found to be more volatile than other actinide metals which lead to the belief that it is divalent in the metallic state; separation of Md from the other actinides can be accomplished either by reduction of Md to the divalent state or by chromatographic separations with Md remaining in the tripositive state; extraction of Md with bis(2-ethylhexyl)phosphoric acid is much poorer than the extraction of the neighboring tripositive actinides; attempts to oxidize Md wih sodium bismuthate failed to show any evidence of Md 4+ ; standard reduction potential of Md 3+ was found to be close to -0.1 volt; Md 3+ can be reduced to Md(Hg) by sodium amalgams and by electrolysis; the electrochemical behavior of Md is very similar to that of Fm and can be summarized in the equation, Md 2+ + 2e - = Md(Hg), and E 0 = 1.5 V

  9. Chemical properties of mendelevium

    International Nuclear Information System (INIS)

    Hulet, E.K.

    1980-11-01

    Even with the most intense ion beams and the largest available quantities of target isotope, about 10 6 atoms at a time is all the Md that can be produced for chemical studies. This lack of sufficient sample size coupled with the very short lifetimes of the few atoms produced has severely restricted the gathering and the broadness of our knowledge concerning the properties of Md and the heavier elements. To illustrate, the literature contains a mere eleven references to the chemical studies of Md, and none of these deal with bulk properties associated with the element bound in solid phases. Some of these findings are: Md was found to be more volatile than other actinide metals which lead to the belief that it is divalent in the metallic state; separation of Md from the other actinides can be accomplished either by reduction of Md 3+ to the divalent state or by chromatographic separations with Md remaining in the tripositive state; extraction of Md 2+ with bis(2-ethylhexyl)phosphoric acid is much poorer than the extraction of the neighboring tripositive actinides; attempts to oxidize Md 3+ with sodium bismuthate failed to show any evidence for Md 4+ ; reduction potential of Md 3+ was found to be close to -0.1 volt; Md 3+ can be reduced to Md(Hg) by sodium amalgams and by electrolysis; the electrochemical behavior of Md is very similar to that of Fm and can be summarized in the equation, Md 2+ + 2e - = Md(Hg) and E 0 = -1.50 V.; and Md cannot be reduced to a monovalent ion with Sm 2+

  10. 7 CFR 250.19 - Reviews.

    Science.gov (United States)

    2010-01-01

    ... or review to determine the extent to which sales are to be disallowed, establish a claim, and/or... 7 Agriculture 4 2010-01-01 2010-01-01 false Reviews. 250.19 Section 250.19 Agriculture Regulations... TERRITORIES AND POSSESSIONS AND AREAS UNDER ITS JURISDICTION General Operating Provisions § 250.19 Reviews. (a...

  11. 30 CFR 250.1401 - Index table.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Index table. 250.1401 Section 250.1401 Mineral... OPERATIONS IN THE OUTER CONTINENTAL SHELF Outer Continental Shelf (OCS) Civil Penalties § 250.1401 Index table. The following table is an index of the sections in this subpart: § 250.1401Table Definitions...

  12. 30 CFR 250.1008 - Reports.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Reports. 250.1008 Section 250.1008 Mineral... OPERATIONS IN THE OUTER CONTINENTAL SHELF Pipelines and Pipeline Rights-of-Way § 250.1008 Reports. (a) The... lessee or right-of-way holder shall submit a report to the Regional Supervisor within 90 days after...

  13. IceMap250—Automatic 250 m Sea Ice Extent Mapping Using MODIS Data

    Directory of Open Access Journals (Sweden)

    Charles Gignac

    2017-01-01

    Full Text Available The sea ice cover in the North evolves at a rapid rate. To adequately monitor this evolution, tools with high temporal and spatial resolution are needed. This paper presents IceMap250, an automatic sea ice extent mapping algorithm using MODIS reflective/emissive bands. Hybrid cloud-masking using both the MOD35 mask and a visibility mask, combined with downscaling of Bands 3–7 to 250 m, are utilized to delineate sea ice extent using a decision tree approach. IceMap250 was tested on scenes from the freeze-up, stable cover, and melt seasons in the Hudson Bay complex, in Northeastern Canada. IceMap250 first product is a daily composite sea ice presence map at 250 m. Validation based on comparisons with photo-interpreted ground-truth show the ability of the algorithm to achieve high classification accuracy, with kappa values systematically over 90%. IceMap250 second product is a weekly clear sky map that provides a synthesis of 7 days of daily composite maps. This map, produced using a majority filter, makes the sea ice presence map even more accurate by filtering out the effects of isolated classification errors. The synthesis maps show spatial consistency through time when compared to passive microwave and national ice services maps.

  14. Dicty_cDB: VFK250 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VF (Link to library) VFK250 (Link to dictyBase) - - - Contig-U13825-1 VFK250P (Link to Original site) VFK2...50F 647 VFK250Z 679 VFK250P 1306 - - Show VFK250 Library VF (Link to library) Clone ID VFK2...e URL http://dictycdb.biol.tsukuba.ac.jp/CSM/VF/VFK2-C/VFK250Q.Seq.d/ Representative seq. ID VFK2...50P (Link to Original site) Representative DNA sequence >VFK250 (VFK250Q) /CSM/VF/VFK2-C/VFK2...re E Sequences producing significant alignments: (bits) Value VFK250 (VFK250Q) /CSM/VF/VFK2-C/VFK250Q.Seq.d/

  15. TAF(II)250: a transcription toolbox.

    Science.gov (United States)

    Wassarman, D A; Sauer, F

    2001-08-01

    Activation of RNA-polymerase-II-dependent transcription involves conversion of signals provided by gene-specific activator proteins into the synthesis of messenger RNA. This conversion requires dynamic structural changes in chromatin and assembly of general transcription factors (GTFs) and RNA polymerase II at core promoter sequence elements surrounding the transcription start site of genes. One hallmark of transcriptional activation is the interaction of DNA-bound activators with coactivators such as the TATA-box binding protein (TBP)-associated factors (TAF(II)s) within the GTF TFIID. TAF(II)250 possesses a variety of activities that are likely to contribute to the initial steps of RNA polymerase II transcription. TAF(II)250 is a scaffold for assembly of other TAF(II)s and TBP into TFIID, TAF(II)250 binds activators to recruit TFIID to particular promoters, TAF(II)250 regulates binding of TBP to DNA, TAF(II)250 binds core promoter initiator elements, TAF(II)250 binds acetylated lysine residues in core histones, and TAF(II)250 possesses protein kinase, ubiquitin-activating/conjugating and acetylase activities that modify histones and GTFs. We speculate that these activities achieve two goals--(1) they aid in positioning and stabilizing TFIID at particular promoters, and (2) they alter chromatin structure at the promoter to allow assembly of GTFs--and we propose a model for how TAF(II)250 converts activation signals into active transcription.

  16. 7 CFR 250.57 - Commodity schools.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Commodity schools. 250.57 Section 250.57 Agriculture... TERRITORIES AND POSSESSIONS AND AREAS UNDER ITS JURISDICTION National School Lunch Program (NSLP) and Other Child Nutrition Programs § 250.57 Commodity schools. (a) Categorization of commodity schools. Commodity...

  17. 31 CFR 250.3 - Voucher applications.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Voucher applications. 250.3 Section 250.3 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE... in 250.4 and returned to the Credit Accounting Branch with the relevant information and the...

  18. 7 CFR 250.21 - Civil rights.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Civil rights. 250.21 Section 250.21 Agriculture... TERRITORIES AND POSSESSIONS AND AREAS UNDER ITS JURISDICTION General Operating Provisions § 250.21 Civil... Department's nondiscrimination regulations (7 CFR parts 15, 15a, and 15b) and the FNS civil rights...

  19. 45 CFR 2541.250 - Program income.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Program income. 2541.250 Section 2541.250 Public... Post-Award Requirements § 2541.250 Program income. (a) General. Grantees are encouraged to earn income to defray program costs. Program income includes income from fees for services performed, from the...

  20. 30 CFR 250.1614 - Mud program.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Mud program. 250.1614 Section 250.1614 Mineral... OPERATIONS IN THE OUTER CONTINENTAL SHELF Sulphur Operations § 250.1614 Mud program. (a) The quantities, characteristics, use, and testing of drilling mud and the related drilling procedures shall be designed and...

  1. 30 CFR 250.300 - Pollution prevention.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Pollution prevention. 250.300 Section 250.300... OPERATIONS IN THE OUTER CONTINENTAL SHELF Pollution Prevention and Control § 250.300 Pollution prevention. (a... pollution occurs as a result of operations conducted by or on behalf of the lessee and the pollution damages...

  2. 30 CFR 250.602 - Equipment movement.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Equipment movement. 250.602 Section 250.602... OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Well-Workover Operations § 250.602 Equipment movement. The movement of well-workover rigs and related equipment on and off a platform or from well to well on...

  3. 30 CFR 250.502 - Equipment movement.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Equipment movement. 250.502 Section 250.502... OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Well-Completion Operations § 250.502 Equipment movement. The movement of well-completion rigs and related equipment on and off a platform or from well to well...

  4. 30 CFR 250.504 - Hydrogen sulfide.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Hydrogen sulfide. 250.504 Section 250.504... OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Well-Completion Operations § 250.504 Hydrogen sulfide. When a well-completion operation is conducted in zones known to contain hydrogen sulfide (H2S) or in...

  5. 30 CFR 250.604 - Hydrogen sulfide.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Hydrogen sulfide. 250.604 Section 250.604... OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Well-Workover Operations § 250.604 Hydrogen sulfide. When a well-workover operation is conducted in zones known to contain hydrogen sulfide (H2S) or in...

  6. 30 CFR 250.808 - Hydrogen sulfide.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Hydrogen sulfide. 250.808 Section 250.808... OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Production Safety Systems § 250.808 Hydrogen sulfide. Production operations in zones known to contain hydrogen sulfide (H2S) or in zones where the presence of H2S...

  7. 21 CFR 74.250 - Orange B.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Orange B. 74.250 Section 74.250 Food and Drugs... ADDITIVES SUBJECT TO CERTIFICATION Foods § 74.250 Orange B. (a) Identity. (1) The color additive Orange B is.... (2) The diluents in color additive mixtures for food use containing Orange B are limited to those...

  8. 14 CFR 250.3 - Boarding priority rules.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Boarding priority rules. 250.3 Section 250...) ECONOMIC REGULATIONS OVERSALES § 250.3 Boarding priority rules. (a) Every carrier shall establish priority... boarding on an oversold flight in the event that an insufficient number of volunteers come forward. Such...

  9. ACT250 Districts

    Data.gov (United States)

    Vermont Center for Geographic Information — The ACT 250 Districts layer is part of a larger dataset that contains administrative boundaries for Vermont's Agency of Natural Resources. The dataset includes...

  10. 30 CFR 250.1200 - Question index table.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Question index table. 250.1200 Section 250.1200 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR... Security § 250.1200 Question index table. The table in this section lists questions concerning Oil and Gas...

  11. 7 CFR 58.250 - Dry whole milk.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Dry whole milk. 58.250 Section 58.250 Agriculture... Products Bearing Usda Official Identification § 58.250 Dry whole milk. Dry whole milk in commercial bulk... Grades of Dry Whole Milk. Quality requirements for dry whole milk in consumer packages shall be for U.S...

  12. 46 CFR 28.250 - High water alarms.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false High water alarms. 28.250 Section 28.250 Shipping COAST... Individuals On Board, or for Fish Tender Vessels Engaged in the Aleutian Trade § 28.250 High water alarms. On... operating station to indicate high water level in each of the following normally unmanned spaces: (a) A...

  13. Dicty_cDB: SSD250 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSD250 (Link to dictyBase) - - - Contig-U14716-1 SSD250E (Link... to Original site) - - - - - - SSD250E 491 Show SSD250 Library SS (Link to library) Clone ID SSD250 (Link to dict...yBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U14716-1 Original site URL http://dict...t alignments: (bits) Value N U20432 |U20432.1 Dictyostelium discoideum TagB (tagB) gene, complete cds. 151 1...cName: Full=Cytochrome b-c1 complex subunit 7; AltNam... 45 0.001 DQ399515_1( DQ399515 |pid:none) Ictalurus

  14. 7 CFR 250.15 - Financial management.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Financial management. 250.15 Section 250.15 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... Financial management. (a) Distribution charges. (1) Recipient agencies may be required to pay part or all of...

  15. 7 CFR 250.1 - General purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false General purpose and scope. 250.1 Section 250.1... AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION DONATION OF FOODS FOR USE IN THE UNITED STATES, ITS TERRITORIES AND POSSESSIONS AND AREAS UNDER ITS JURISDICTION General § 250.1 General purpose and...

  16. Extensive interactions between HIV TAT and TAF(II)250.

    Science.gov (United States)

    Weissman, J D; Hwang, J R; Singer, D S

    2001-03-09

    The HIV transactivator, Tat, has been shown to be capable of potent repression of transcription initiation. Repression is mediated by the C-terminal segment of Tat, which binds the TFIID component, TAF(II)250, although the site(s) of interaction were not defined previously. We now report that the interaction between Tat and TAF(II)250 is extensive and involves multiple contacts between the Tat protein and TAF(II)250. The C-terminal domain of Tat, which is necessary for repression of transcription initiation, binds to a segment of TAF(II)250 that encompasses its acetyl transferase (AT) domain (885-1034 amino acids (aa)). Surprisingly, the N-terminal segment of Tat, which contains its activation domains, also binds to TAF(II)250 and interacts with two discontinuous segments of TAF(II)250 located between 885 and 984 aa and 1120 and 1279 aa. Binding of Tat to the 885-984 aa segment of TAF(II)250 requires the cysteine-rich domain of Tat, but not the acidic or glutamine-rich domains. Binding by the N-terminal domain of Tat to the 1120-1279 aa TAF(II)250 segment does not involve the acidic, cysteine- or glutamine-rich domains. Repression of transcription initiation by Tat requires functional TAF(II)250. We now demonstrate that transcription of the HIV LTR does not depend on TAF(II)250 which may account for its resistance to Tat mediated repression.

  17. 30 CFR 250.302 - Definitions concerning air quality.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Definitions concerning air quality. 250.302... Definitions concerning air quality. For purposes of §§ 250.303 and 250.304 of this part: Air pollutant means..., pursuant to section 109 of the Clean Air Act, national primary or secondary ambient air quality standards...

  18. 30 CFR 250.212 - What information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... by § 250.218; (g) Oil and hazardous substance spills information required by § 250.219; (h) Alaska... Section 250.212 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND... support facilities information required by § 250.225; (n) Coastal zone management information required by...

  19. 14 CFR 250.8 - Denied boarding compensation.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Denied boarding compensation. 250.8 Section... PROCEEDINGS) ECONOMIC REGULATIONS OVERSALES § 250.8 Denied boarding compensation. (a) Every carrier shall tender to a passenger eligible for denied boarding compensation, on the day and place the denied boarding...

  20. 21 CFR 173.250 - Methyl alcohol residues.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Methyl alcohol residues. 173.250 Section 173.250 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD.... Methyl alcohol may be present in the following foods under the conditions specified: (a) In spice...

  1. 30 CFR 250.242 - What information must accompany the DPP or DOCD?

    Science.gov (United States)

    2010-07-01

    ... § 250.248; (g) Air emissions information required by § 250.249; (h) Oil and hazardous substance spills...? 250.242 Section 250.242 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR....258; (q) Sulphur operations information required by § 250.259; (r) Coastal zone management information...

  2. 12 CFR 250.260 - Miscellaneous interpretations; gold coin and bullion.

    Science.gov (United States)

    2010-01-01

    ... requirements? No. Section 19(c) of the Federal Reserve Act requires that reserve balances be satisfied either... bullion. 250.260 Section 250.260 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM MISCELLANEOUS INTERPRETATIONS Interpretations § 250.260 Miscellaneous...

  3. 30 CFR 250.510 - Diesel engine air intakes.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Diesel engine air intakes. 250.510 Section 250... engine air intakes. Diesel engine air intakes must be equipped with a device to shut down the diesel engine in the event of runaway. Diesel engines that are continuously attended must be equipped with...

  4. 41 CFR 60-250.24 - Drugs and alcohol.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Drugs and alcohol. 60-250... VETERANS Discrimination Prohibited § 60-250.24 Drugs and alcohol. (a) Specific activities permitted. The contractor: (1) May prohibit the illegal use of drugs and the use of alcohol at the workplace by all...

  5. 30 CFR 250.1626 - Tubing and wellhead equipment.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Tubing and wellhead equipment. 250.1626 Section... GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Sulphur Operations § 250.1626 Tubing and wellhead equipment. (a) No tubing string shall be placed into service or continue to be used unless such...

  6. 30 CFR 250.610 - Diesel engine air intakes.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Diesel engine air intakes. 250.610 Section 250... engine air intakes. No later than May 31, 1989, diesel engine air intakes shall be equipped with a device to shut down the diesel engine in the event of runaway. Diesel engines which are continuously...

  7. 30 CFR 250.1628 - Design, installation, and operation of production systems.

    Science.gov (United States)

    2010-07-01

    ... Operations § 250.1628 Design, installation, and operation of production systems. (a) General. All production... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Design, installation, and operation of production systems. 250.1628 Section 250.1628 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF...

  8. 21 CFR 250.201 - Preparations for the treatment of pernicious anemia.

    Science.gov (United States)

    2010-04-01

    ... anemia. 250.201 Section 250.201 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... Drugs and Foods § 250.201 Preparations for the treatment of pernicious anemia. (a) The ninth announcement of the Anti-anemia Preparations Advisory Board of the United States Pharmacopeia is concerned with...

  9. Chemistry of the heaviest elements--one atom at a time

    International Nuclear Information System (INIS)

    Hoffman, Darleane C.; Lee, Diana M.

    2000-01-01

    In keeping with the goal of the Viewpoint series of the Journal of Chemical Education, this article gives a 75-year perspective of the chemistry of the heaviest elements, including a 50-year retrospective view of past developments, a summary of current research achievements and applications, and some predictions about exciting, new developments that might be envisioned within the next 25 years. A historical perspective of the importance of chemical separations in the discoveries of the transuranium elements from neptunium (Z=93) through mendelevium (Z=101) is given. The development of techniques for studying the chemical properties of mendelevium and still heavier elements on the basis of measuring the radioactive decay of a single atom (''atom-at-a-time'' chemistry) and combining the results of many separate experiments is reviewed. The influence of relativistic effects (expected to increase as Z 2 ) on chemical properties is discussed. The results from recent atom-at-a-time studies of the chemistry of the heaviest elements through seaborgium (Z=106) are summarized and show that their properties cannot be readily predicted based on simple extrapolation from the properties of their lighter homologues in the periodic table. The prospects for extending chemical studies to still heavier elements than seaborgium are considered and appear promising

  10. 14 CFR 250.2a - Policy regarding denied boarding.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Policy regarding denied boarding. 250.2a... PROCEEDINGS) ECONOMIC REGULATIONS OVERSALES § 250.2a Policy regarding denied boarding. In the event of an... confirmed reserved space on that flight are denied boarding involuntarily. ...

  11. 21 CFR 1271.250 - Labeling controls.

    Science.gov (United States)

    2010-04-01

    ..., AND CELLULAR AND TISSUE-BASED PRODUCTS Current Good Tissue Practice § 1271.250 Labeling controls. (a... available for distribution is accompanied by documentation of the donor eligibility determination as...

  12. 30 CFR 250.463 - Who establishes field drilling rules?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Who establishes field drilling rules? 250.463... GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Other Drilling Requirements § 250.463 Who establishes field drilling rules? (a) The District Manager may...

  13. 40 CFR 265.250 - Applicability.

    Science.gov (United States)

    2010-07-01

    ... Piles § 265.250 Applicability. The regulations in this subpart apply to owners and operators of facilities that treat or store hazardous waste in piles, except as § 265.1 provides otherwise. Alternatively, a pile of hazardous waste may be managed as a landfill under subpart N. ...

  14. 7 CFR 250.17 - Reports.

    Science.gov (United States)

    2010-01-01

    ...) Inventory reports and receipt of donated foods. Distributing agencies shall complete and submit to the FNSRO semiannual reports regarding excessive inventories (as defined in § 250.14(f)) of donated foods, utilizing form FNS-155, the Inventory Management Register, except that distributing agencies shall submit monthly...

  15. 40 CFR 264.250 - Applicability.

    Science.gov (United States)

    2010-07-01

    ... OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Waste Piles § 264.250... treat hazardous waste in piles, except as § 264.1 provides otherwise. (b) The regulations in this subpart do not apply to owners or operators of waste piles that are closed with wastes left in place. Such...

  16. 30 CFR 250.518 - What are the requirements for casing pressure management?

    Science.gov (United States)

    2010-07-01

    ... Operations Casing Pressure Management § 250.518 What are the requirements for casing pressure management... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the requirements for casing pressure management? 250.518 Section 250.518 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR...

  17. 30 CFR 250.131 - Will MMS notify me before conducting an inspection?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Will MMS notify me before conducting an inspection? 250.131 Section 250.131 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... § 250.131 Will MMS notify me before conducting an inspection? MMS conducts both scheduled and...

  18. 30 CFR 250.231 - After receiving the EP, what will MMS do?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false After receiving the EP, what will MMS do? 250.231 Section 250.231 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE... Decision Process for the Ep § 250.231 After receiving the EP, what will MMS do? (a) Determine whether...

  19. 30 CFR 250.123 - Will MMS allow gas storage on unleased lands?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Will MMS allow gas storage on unleased lands? 250.123 Section 250.123 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... § 250.123 Will MMS allow gas storage on unleased lands? You may not store gas on unleased lands unless...

  20. 30 CFR 250.207 - What ancillary activities may I conduct?

    Science.gov (United States)

    2010-07-01

    ... surveys; or (c) Studies that model potential oil and hazardous substance spills, drilling muds and... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What ancillary activities may I conduct? 250.207 Section 250.207 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE...

  1. Johann Wilhelm Krause 250 / Triin Ojari

    Index Scriptorium Estoniae

    Ojari, Triin, 1974-

    2007-01-01

    Eesti klassitsistliku arhitektuuri suurkuju ning Tartu Ülikooli arhitekti Johann Wilhelm Krause 250. sünniaastapäeva tähistati näitustega Tallinnas ja Tartus. Tartu Ülikooli raamatukogu kunstikogusse kuulub ligi 700 J. W. Krause loodud joonistust

  2. 30 CFR 250.1504 - May I use alternative training methods?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false May I use alternative training methods? 250... Safety Training § 250.1504 May I use alternative training methods? You may use alternative training methods. These methods may include computer-based learning, films, or their equivalents. This training...

  3. 7 CFR 250.13 - Distribution and control of donated foods.

    Science.gov (United States)

    2010-01-01

    ...) Minimum donations. Foods shall be donated only in such quantities as will protect the lower truck load... 7 Agriculture 4 2010-01-01 2010-01-01 false Distribution and control of donated foods. 250.13 Section 250.13 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION...

  4. Hybrid Propulsion Demonstration Program 250K Hybrid Motor

    Science.gov (United States)

    Story, George; Zoladz, Tom; Arves, Joe; Kearney, Darren; Abel, Terry; Park, O.

    2003-01-01

    The Hybrid Propulsion Demonstration Program (HPDP) program was formed to mature hybrid propulsion technology to a readiness level sufficient to enable commercialization for various space launch applications. The goal of the HPDP was to develop and test a 250,000 pound vacuum thrust hybrid booster in order to demonstrate hybrid propulsion technology and enable manufacturing of large hybrid boosters for current and future space launch vehicles. The HPDP has successfully conducted four tests of the 250,000 pound thrust hybrid rocket motor at NASA's Stennis Space Center. This paper documents the test series.

  5. 5 CFR 250.203 - Agency responsibilities.

    Science.gov (United States)

    2010-01-01

    ... management on its overall mission performance. (2) Human capital accountability system. This system provides... MANAGEMENT IN AGENCIES Strategic Human Capital Management § 250.203 Agency responsibilities. (a) To assist in... and initiatives as appropriate, consistent with agency strategic plans and annual performance goals...

  6. 30 CFR 250.1152 - How do I conduct well tests?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I conduct well tests? 250.1152 Section... Tests and Surveys § 250.1152 How do I conduct well tests? (a) When you conduct well tests you must: (1... during completion, recompletion, reworking, or treatment operations before you start a well test; (2...

  7. 21 CFR 172.250 - Petroleum naphtha.

    Science.gov (United States)

    2010-04-01

    ... naphtha is used or intended for use as a solvent in protective coatings on fresh citrus fruit in... CONSUMPTION (CONTINUED) FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Coatings...-oxidation, the entire procedure is to be carried out under subdued light. apparatus Separatory funnels. 250...

  8. 30 CFR 250.1634 - Site security.

    Science.gov (United States)

    2010-07-01

    ... Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Sulphur Operations § 250.1634 Site security. (a) All locations... Regional Supervisor as soon as possible but no later than the next business day after discovery of the...

  9. 30 CFR 250.1406 - When will MMS notify me and provide penalty information?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When will MMS notify me and provide penalty information? 250.1406 Section 250.1406 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... (OCS) Civil Penalties § 250.1406 When will MMS notify me and provide penalty information? If the...

  10. 14 CFR 250.6 - Exceptions to eligibility for denied boarding compensation.

    Science.gov (United States)

    2010-01-01

    ... boarding compensation. 250.6 Section 250.6 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF... boarding compensation. A passenger denied boarding involuntarily from an oversold flight shall not be eligible for denied boarding compensation if: (a) The passenger does not comply fully with the carrier's...

  11. 7 CFR 250.52 - Storage and inventory management of donated foods.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Storage and inventory management of donated foods. 250... Donated Foods in Contracts With Food Service Management Companies § 250.52 Storage and inventory management of donated foods. (a) General requirements. The food service management company must meet the...

  12. 48 CFR 52.250-1 - Indemnification Under Public Law 85-804.

    Science.gov (United States)

    2010-10-01

    ... caused by willful misconduct or lack of good faith on the part of any of the Contractor's principal... Public Law 85-804. 52.250-1 Section 52.250-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and...

  13. 40 CFR 421.250 - Applicability: Description of the primary precious metals and mercury subcategory.

    Science.gov (United States)

    2010-07-01

    ... primary precious metals and mercury subcategory. 421.250 Section 421.250 Protection of Environment... POINT SOURCE CATEGORY Primary Precious Metals and Mercury Subcategory § 421.250 Applicability: Description of the primary precious metals and mercury subcategory. The provisions of this subpart are...

  14. 17 CFR 250.4 - Exemption of certain brokers, dealers and underwriters.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Exemption of certain brokers... and General Exemptions § 250.4 Exemption of certain brokers, dealers and underwriters. (a) General exemption. Subject to the provision of § 250.6, any broker, dealer or underwriter, as defined in paragraph...

  15. Pulverização em CDA 250 herbicida pendimethalin na cultura do arroz de sequeiro Application of pendimethalin with cda 250 spfayer for upland rice

    Directory of Open Access Journals (Sweden)

    T. Matuo

    1984-01-01

    Full Text Available Foi estudada a viabilidade de utilização da pulverização CDA 25C, na aplicação do herbicida em pré-emergência na cultura do arroz de sequeiro. O herbicida empregado foi o pendimethalin nas doses de 0,0; 1,5; 2,0; 2,5 e 3,0 litro s/ha da formulação comercial a 50%. A pulverização convencional foi efetuada com bicos 11003 com consumo de 200 litros de calda per hectare. O processo CDA 250 foi aplicado por meio de bico rotativo (Micromax com dois níveis de consumo de calda : 50 1/ha e 27 1/ha. Os resultados mostraram que: a - o método CDA 250 proporciona controle dc mato e produtividade de arroz equivalentes ao método convencional; b para o bico Micromax, a aplicação da formulação comercial de pendimethalin a 50% com vazão de 0,48 1/min./bico, a distância entre bicos deve ser de 1,75 m e para a vazão de 0,96 1/min./bloco, essa distancia deve ser de 1,90 m; c- a aplicação do pendimethalin 50% C.E. pelo processo CDA 250, empregando 27 litros de calda por hectare foi o processo mais interessante por oferecer vantagens logísticas apreciáveis.The feasibility of pre-emergenge herbicide application for upland rice by CDA 250 spray method was studied. The herbicide used was pen dimethalin at 0,0; 1,5; 2,0; 2,5 and 3,0 1/ha of comercial 50% E.C. formulation. Conventional spraying was carried out using 110C3 flat fan nozzles applying 200 1/ha of spray volume CDA250 was applied by rotary atomizers (Micromax spraying twc volume rates: 50 1/ha and 27 1/ha. The results pointed out that: a- CDA 250 spray method was equivalent to the conventional spray method in the control of weeds and crop yield; b - for Micromax nozzles applying commercial 50 E.C. formulation of pendimethalin at 0,48 /min of nozzle feed rate, the distance between nozzles should be 1,75 m and at 0,96 1/min feed rate this distance shoud be 1,90 m; c- CDA 250, applying 27 1/ha presents large logistic advantages.

  16. 33 CFR 96.250 - What documents and reports must a safety management system have?

    Science.gov (United States)

    2010-07-01

    ... safety management system have? 96.250 Section 96.250 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY VESSEL OPERATING REGULATIONS RULES FOR THE SAFE OPERATION OF VESSELS AND SAFETY MANAGEMENT SYSTEMS Company and Vessel Safety Management Systems § 96.250 What documents and...

  17. 13 CFR 107.250 - Exclusion of stock options issued by Licensee from Management Expenses.

    Science.gov (United States)

    2010-01-01

    ... Sbic § 107.250 Exclusion of stock options issued by Licensee from Management Expenses. Stock options... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Exclusion of stock options issued by Licensee from Management Expenses. 107.250 Section 107.250 Business Credit and Assistance SMALL...

  18. 17 CFR 250.28 - Inconsistent financial statements.

    Science.gov (United States)

    2010-04-01

    ... Accounts § 250.28 Inconsistent financial statements. Except as otherwise authorized or required by the..., financial statements which are inconsistent with the book accounts of such company or financial statements... prevent the distribution or publication of reasonable condensations or of unaudited financial statements...

  19. 5 CFR 250.201 - Coverage and purpose.

    Science.gov (United States)

    2010-01-01

    ....201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL MANAGEMENT IN AGENCIES Strategic Human Capital Management § 250.201 Coverage and purpose. The Chief Human... effective and efficient operation of Government. As a part of OPM's overall leadership responsibilities in...

  20. 30 CFR 250.109 - What documents must I prepare and maintain related to welding?

    Science.gov (United States)

    2010-07-01

    ... related to welding? 250.109 Section 250.109 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF... Performance Standards § 250.109 What documents must I prepare and maintain related to welding? (a) You must submit a Welding Plan to the District Manager before you begin drilling or production activities on a...

  1. Studies of neutron-deficient mendelevium isotopes at SHIP

    Energy Technology Data Exchange (ETDEWEB)

    Antalic, S.; Saro, S. [Comenius University, Department of Nuclear Physics and Biophysics, Bratislava (Slovakia); Hessberger, F.P.; Ackermann, D.; Heinz, S.; Kindler, B.; Kojouharov, I.; Lommel, B.; Mann, R. [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Darmstadt (Germany); Hofmann, S. [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Darmstadt (Germany); Goethe-Universitaet, Institut fuer Kernphysik, Frankfurt am Main (Germany); Kuusiniemi, P. [University of Oulu, Centre for Underground Physics in Pyhaesalmi (CUPP), Oulu (Finland); Leino, M. [University of Jyvaeskylae, Department of Physics, Jyvaeskylae (Finland)

    2010-01-15

    The radioactive decay of the isotopes {sup 247}Md, {sup 246}Md and their daughter products was investigated by means of {alpha}-{alpha} and {alpha}-{gamma} coincidence spectroscopy. The isotopes were produced using the fusion reaction {sup 40}Ar + {sup 209}Bi. Decay schemes are suggested for {sup 247}Md and {sup 243}Es. A new isomeric state in {sup 246}Md with a half-life of (4.4{+-}0.8) s was observed. Previous data of electron-capture delayed fission of {sup 246}Md and {sup 242}Es were confirmed. The probability for this decay branch in {sup 246}Md was measured to be P{sub ECDF}>0.10. The probability for electron-capture delayed fission in the case of {sup 242}Es was determined to be P{sub ECDF}=0.013{sup +0.012} {sub -0.007}. (orig.)

  2. 30 CFR 250.1711 - When will MMS order me to permanently plug a well?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When will MMS order me to permanently plug a well? 250.1711 Section 250.1711 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... Activities Permanently Plugging Wells § 250.1711 When will MMS order me to permanently plug a well? MMS will...

  3. 30 CFR 250.204 - How must I protect the rights of the Federal government?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How must I protect the rights of the Federal government? 250.204 Section 250.204 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... Information § 250.204 How must I protect the rights of the Federal government? (a) To protect the rights of...

  4. 30 CFR 250.266 - After receiving the DPP or DOCD, what will MMS do?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false After receiving the DPP or DOCD, what will MMS do? 250.266 Section 250.266 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... Decision Process for the Dpp Or Docd § 250.266 After receiving the DPP or DOCD, what will MMS do? (a...

  5. The Varian MAT-250 mass spectrometer. Steady isotopes laboratory; Espectrometro de masas Varian MAT-250. Laboratorio de isotopos estables

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez M, V.; Tavera D, M.L. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1997-07-01

    This work treats over the performance and applications of the Varian Mat-250 mass spectrometer which is in the environmental isotope laboratory. It can be applied over topics such as: ions formation, acceleration and collimation, ions separation, ions detection, data transformation, sampling, {delta} notation. (Author)

  6. 30 CFR 250.1202 - Liquid hydrocarbon measurement.

    Science.gov (United States)

    2010-07-01

    ... FMPs; Inclusion of production from additional structures; Meter updates which add buy-back gas meters... the API MPMS as incorporated by reference in 30 CFR 250.198, when obtaining net standard volume and... manufacturer; (ii) Meters operate within the manufacturer's specifications for maximum and minimum flow rate...

  7. Galvanic interactions of HE15 /MDN138 & HE15 /MDN250 alloys in natural seawater

    Science.gov (United States)

    Parthiban, G. T.; Subramanian, G.; Muthuraman, K.; Ramakrishna Rao, P.

    2017-06-01

    HE15 is a heat treatable high strength alloy with excellent machinability find wide applications in aerospace and defence industries. In view of their excellent mechanical properties, workability, machinability, heat treatment characteristics and good resistance to general and stress corrosion cracking, MDN138 & MDN250 have been widely used in petrochemical, nuclear and aerospace industries. The galvanic corrosion behaviour of the metal combinations HE15 /MDN138 and HE15 /MDN250, with 1:1 area ratio, has been studied in natural seawater using the open well facility of CECRI's Offshore Platform at Tuticorin for a year. The open circuit potentials of MDN138, MDN250 and HE15 of the individual metal, the galvanic potential and galvanic current of the couples HE15 /MDN138 and HE15 /MDN250 were periodically monitored throughout the study period. The calcareous deposits on MDN138 and MDN250 in galvanic contact with HE15 were analyzed using XRD. The electrochemical behaviors of MDN138, MDN250 and HE15 in seawater have been studied using an electrochemical work station. The surface characteristics of MDN138 and MDN250 in galvanic contact with HE15 have been examined with scanning electron microscope. The results of the study reveal that HE15 offered required amount of protection to MDN138 & MDN250.

  8. 30 CFR 250.221 - What environmental monitoring information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What environmental monitoring information must accompany the EP? 250.221 Section 250.221 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... necessary under the MMPA. (c) Flower Garden Banks National Marine Sanctuary (FGBNMS). If you propose to...

  9. New model for the lunar interior to 250 km

    International Nuclear Information System (INIS)

    Piwinskii, A.J.; Duba, A.G.

    1975-01-01

    A new model for the structure of the lunar interior to about a 250-km depth is proposed. It is suggested that this region is composed of plagioclase-bearing rocks, and that the 65-km seismic discontinuity represents the appearance of garnet. A variety of rock types mainly composed of plagioclase, pyroxene, olivine and garnet is envisioned, with at least half of the outer 250 km of the moon made of plagioclase, which dominates the electrical conductivity. This model agrees with recent petrological and electrical conductivity results and does not violate velocity-depth profiles obtained from elastic-wave studies of lunar and terrestrial materials. (U.S.)

  10. Actinides

    International Nuclear Information System (INIS)

    Martinot, L.; Fuger, J.

    1985-01-01

    The oxidation behavior of the actinides is explained on the basis of their electronic structure. The actinide elements, actinium, thorium, protactinium, uranium, neptunium, plutonium, americium, curium, berkelium, californium, einsteinium, fermium, mendelevium, nobelium, and laurencium are included. For all except the last three elements, the points of discussion are oxidation states, Gibbs energies and potentials, and potential diagram for the element in acid solution; and thermodynamic properties of these same elements are tabulated. References are cited following discussion of each element with a total of 97 references being cited. 13 tables

  11. 30 CFR 250.1003 - Installation, testing, and repair requirements for DOI pipelines.

    Science.gov (United States)

    2010-07-01

    .... (a)(1) Pipelines greater than 8-5/8 inches in diameter and installed in water depths of less than 200... for DOI pipelines. 250.1003 Section 250.1003 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Pipelines...

  12. Targeted therapy of renal cell carcinoma: synergistic activity of cG250-TNF and IFNg.

    NARCIS (Netherlands)

    Bauer, S.; Oosterwijk-Wakka, J.C.; Adrian, N.; Oosterwijk, E.; Fischer, E.; Wuest, T.; Stenner, F.; Perani, A.; Cohen, L.; Knuth, A.; Divgi, C.; Jager, D.; Scott, A.M.; Ritter, G.; Old, L.J.; Renner, C.

    2009-01-01

    Immunotherapeutic targeting of G250/Carbonic anhydrase IX (CA-IX) represents a promising strategy for treatment of renal cell carcinoma (RCC). The well characterized human-mouse chimeric G250 (cG250) antibody has been shown in human studies to specifically enrich in CA-IX positive tumors and was

  13. 30 CFR 250.195 - What notification does MMS require on the production status of wells?

    Science.gov (United States)

    2010-07-01

    ... the well in a production status. You must confirm oral notification by telefax or e-mail within those... production status of wells? 250.195 Section 250.195 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT... Information and Reporting Requirements § 250.195 What notification does MMS require on the production status...

  14. 30 CFR 250.226 - What Coastal Zone Management Act (CZMA) information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What Coastal Zone Management Act (CZMA) information must accompany the EP? 250.226 Section 250.226 Mineral Resources MINERALS MANAGEMENT SERVICE... and Information Contents of Exploration Plans (ep) § 250.226 What Coastal Zone Management Act (CZMA...

  15. 14 CFR 250.2b - Carriers to request volunteers for denied boarding.

    Science.gov (United States)

    2010-01-01

    ... boarding. 250.2b Section 250.2b Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION... boarding. (a) In the event of an oversold flight, every carrier shall request volunteers for denied boarding before using any other boarding priority. A “volunteer” is a person who responds to the carrier's...

  16. Transactivation mediated by B-Myb is dependent on TAF(II)250.

    Science.gov (United States)

    Bartusel, Thorsten; Klempnauer, Karl-Heinz

    2003-05-15

    B-Myb is a highly conserved member of the Myb family of transcription factors, which has been implicated in cell cycle regulation. B-Myb is expressed in most proliferating cells and its activity is highly regulated around the G1/S-phase border of the cell cycle. It is generally assumed that B-Myb regulates the expression of genes that are crucial for cell proliferation; however, the identity of these genes, the molecular mechanisms by which B-Myb stimulates their expression and the involvement of other proteins have not been sufficiently clarified. We have employed the hamster cell line ts13 as a tool to demonstrate a functional link between B-Myb and the coactivator TAF(II)250, a key component of the transcriptional machinery which itself is essential for cell proliferation. ts13 cells express a point-mutated version of TAF(II)250 whose intrinsic histone acetyl transferase activity is temperature sensitive. Transactivation of Myb-responsive reporter genes by B-Myb is temperature-dependent in ts13 cells but not in ts13 cells, which have been rescued by transfection with an expression vector for wild-type TAF(II)250. Furthermore, B-Myb and TAF(II)250 can be coprecipitated, suggesting that both proteins are present in a complex. The formation of this complex is dependent on the DNA-binding domain of B-Myb and not on its transactivation domain. Taken together, these observations provide the first evidence that the coactivator TAF(II)250 is involved in the activation of Myb responsive promoters by B-Myb. The finding that B-Myb transactivation is dependent on a key coactivator involved in cell cycle control is consistent with and strengthens the idea that B-Myb plays a crucial role as a transcription factor in proliferating cells.

  17. Valurautaisten 160 - 250 kokoluokan jarrumoottorien suunnitteluohje

    OpenAIRE

    Järvi, Markus

    2016-01-01

    ABB Oy:n Motors and Generators – yksikön sovellussuunnitteluosasto tarvitsi suunnitteluohjetta valurautaisille 160 – 250 kokoluokan jarrumoottoreille. Jarrumoottoreiden suunnittelu ja tuotanto ohjattiin vuoden 2015 keväällä Vaasan moottoritehtaalle ja Ruotsista tulleet ohjeet sekä dokumentointi kaipasivat parannusta. Ohjeen tarkoituksena on olla suunnittelun ja myynnin tukena. Ohje on tehty englannin kielellä, jotta sitä pystytään käyttämään ABB:n organisaatiossa myös Suomen ulkopuolella. ...

  18. 30 CFR 250.286 - What is a DWOP?

    Science.gov (United States)

    2010-07-01

    ... development project, and any other project that uses non-conventional production or completion technology... Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Plans and Information Deepwater Operations Plans (dwop) § 250.286...

  19. 30 CFR 250.107 - What must I do to protect health, safety, property, and the environment?

    Science.gov (United States)

    2010-07-01

    ..., property, and the environment? 250.107 Section 250.107 Mineral Resources MINERALS MANAGEMENT SERVICE... Performance Standards § 250.107 What must I do to protect health, safety, property, and the environment? (a) You must protect health, safety, property, and the environment by: (1) Performing all operations in a...

  20. 34 CFR 75.250 - Project period can be up to 60 months.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Project period can be up to 60 months. 75.250 Section... Are Made Approval of Multi-Year Projects § 75.250 Project period can be up to 60 months. The Secretary may approve a project period of up to 60 months. (Authority: 20 U.S.C. 1221e-3 and 3474) [45 FR 22497...

  1. Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis.

    Science.gov (United States)

    Wang, P Jeremy; Page, David C

    2002-09-15

    TAF(II)250, the largest subunit of the general transcription factor TFIID, is expressed from the human X chromosome, at least in somatic cells. In male meiosis, however, the sex chromosomes are transcriptionally silenced, while the autosomes remain active. How then are protein-encoding genes transcribed during human male meiosis? Here we present a novel autosomal human gene, TAF1L, which is homologous to TAF(II)250 and is expressed specifically in the testis, apparently in germ cells. We hypothesize that during male meiosis, transcription of protein-encoding genes relies upon TAF1L as a functional substitute for TAF(II)250. Like TAF(II)250, the human TAF1L protein can bind directly to TATA-binding protein, an essential component of TFIID. Most importantly, transfection with human TAF1L rescued the temperature-sensitive lethality of a hamster cell line mutant in TAF(II)250. TAF1L lacks introns and evidently arose by retroposition of a processed TAF(II)250 mRNA during primate evolution. The observation that TAF1L can functionally replace TAF(II)250 provides experimental support for the hypothesis that during male meiosis, autosomes provide cellular functions usually supplied by the X chromosome in somatic cells.

  2. 30 CFR 250.921 - How do I analyze my platform for cumulative fatigue?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I analyze my platform for cumulative fatigue? 250.921 Section 250.921 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... fatigue? (a) If you are required to analyze cumulative fatigue on your platform because of the results of...

  3. 47 CFR 10.250 - Notification to existing subscribers of non-participation in CMAS.

    Science.gov (United States)

    2010-10-01

    ... provider shall use any reasonable method at its disposal to alert the customer to a change in the terms and...-participation in CMAS. 10.250 Section 10.250 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL... Rule 47 CFR 10.240. (c) In the case of prepaid customers, if a mailing address is available, the CMS...

  4. 7 CFR 250.60 - Use of donated foods in the school food service.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Use of donated foods in the school food service. 250.60 Section 250.60 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION DONATION OF FOODS FOR USE IN THE UNITED STATES, ITS...

  5. 30 CFR 250.617 - Tubing and wellhead equipment.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Tubing and wellhead equipment. 250.617 Section... Tubing and wellhead equipment. The lessee shall comply with the following requirements during well-workover operations with the tree removed: (a) No tubing string shall be placed in service or continue to...

  6. 30 CFR 250.401 - What must I do to keep wells under control?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I do to keep wells under control? 250... General Requirements § 250.401 What must I do to keep wells under control? You must take necessary precautions to keep wells under control at all times. You must: (a) Use the best available and safest drilling...

  7. Memory timeline: Brain ERP C250 (not P300) is an early biomarker of short-term storage.

    Science.gov (United States)

    Chapman, Robert M; Gardner, Margaret N; Mapstone, Mark; Dupree, Haley M; Antonsdottir, Inga M

    2015-04-16

    Brain event-related potentials (ERPs) offer a quantitative link between neurophysiological activity and cognitive performance. ERPs were measured while young adults performed a task that required storing a relevant stimulus in short-term memory. Using principal components analysis, ERP component C250 (maximum at 250 ms post-stimulus) was extracted from a set of ERPs that were separately averaged for various task conditions, including stimulus relevancy and stimulus sequence within a trial. C250 was more positive in response to task-specific stimuli that were successfully stored in short-term memory. This relationship between C250 and short-term memory storage of a stimulus was confirmed by a memory probe recall test where the behavioral recall of a stimulus was highly correlated with its C250 amplitude. ERP component P300 (and its subcomponents of P3a and P3b, which are commonly thought to represent memory operations) did not show a pattern of activation reflective of storing task-relevant stimuli. C250 precedes the P300, indicating that initial short-term memory storage may occur earlier than previously believed. Additionally, because C250 is so strongly predictive of a stimulus being stored in short-term memory, C250 may provide a strong index of early memory operations. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. 17 CFR 250.8 - Exemption of subsidiaries subject to jurisdiction of Interstate Commerce Commission.

    Science.gov (United States)

    2010-04-01

    ... subject to jurisdiction of Interstate Commerce Commission. 250.8 Section 250.8 Commodity and Securities... to jurisdiction of Interstate Commerce Commission. Any subsidiary company of a registered holding company, which subsidiary is subject to the jurisdiction of the Interstate Commerce Commission but is not...

  9. 30 CFR 250.517 - Tubing and wellhead equipment.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Tubing and wellhead equipment. 250.517 Section... Tubing and wellhead equipment. (a) No tubing string shall be placed in service or continue to be used unless such tubing string has the necessary strength and pressure integrity and is otherwise suitable for...

  10. 30 CFR 250.511 - Traveling-block safety device.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Traveling-block safety device. 250.511 Section... Traveling-block safety device. All units being used for well-completion operations that have both a traveling block and a crown block must be equipped with a safety device that is designed to prevent the...

  11. 17 CFR 250.12 - Exemption of certain public utility companies from the definition of subsidiary companies of...

    Science.gov (United States)

    2010-04-01

    ... utility companies from the definition of subsidiary companies of holding companies. 250.12 Section 250.12... REGULATIONS, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 Registration and General Exemptions § 250.12 Exemption of certain public utility companies from the definition of subsidiary companies of holding companies...

  12. 14 CFR 250.5 - Amount of denied boarding compensation for passengers denied boarding involuntarily.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Amount of denied boarding compensation for passengers denied boarding involuntarily. 250.5 Section 250.5 Aeronautics and Space OFFICE OF THE SECRETARY... boarding compensation for passengers denied boarding involuntarily. (a) Subject to the exceptions provided...

  13. 30 CFR 250.260 - What Coastal Zone Management Act (CZMA) information must accompany the DPP or DOCD?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What Coastal Zone Management Act (CZMA) information must accompany the DPP or DOCD? 250.260 Section 250.260 Mineral Resources MINERALS MANAGEMENT... Operations Coordination Documents (docd) § 250.260 What Coastal Zone Management Act (CZMA) information must...

  14. 30 CFR 250.611 - Traveling-block safety device.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Traveling-block safety device. 250.611 Section... Traveling-block safety device. After May 31, 1989, all units being used for well-workover operations which have both a traveling block and a crown block shall be equipped with a safety device which is designed...

  15. 30 CFR 250.918 - What are the CVA's primary duties during the installation phase?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the CVA's primary duties during the installation phase? 250.918 Section 250.918 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... appropriate (i) Loadout and initial flotation operations; (ii) Towing operations to the specified location...

  16. Kr and Xe isotopes from spontaneous fission of 248Cm and 250Cf

    International Nuclear Information System (INIS)

    Srinivasan, B.

    1980-01-01

    Relative yields of Kr and Xe isotopes from the spontaneous fission of 248 Cm and 250 Cf have been determined mass spectrometrically. The yields are as follows: 83 Kr/ 84 Kr/ 85 Kr/ 86 Kr = 0.223/0.458/0.596/ identical 1.00 and 0.306/0.582/0.793/ identical 1.00; 131 Xe/ 134 Xe/ 136 Xe = 0.486/0.819/1.075 identical 1.00 and 0.343/0.506/0.851/ identical 1.00 from 248 Cm and 250 Cf, respectively. The Xe yields from 248 Cm agree with an earlier determination by Leich et al. Neither of these yield patterns matches that of fissiogenic Kr and Xe in carbonaceous chondrites and hence 248 Cm and 250 Cf are ruled out as progenitors of the meteoritic Kr and Xe. In general, none of the spontaneously fissioning nuclides of actinide elements can be identified as a possible progenitor. Even the mixtures of actinides, including a combination of 248 Cm and 250 Cm, are unsuitable. The origin of anomalous Kr and Xe in carbonaceous chondrites must then be traced either to the spontaneous fission of a superheavy element or to peculiarities in specific nucleosynthetic reactions. (orig.)

  17. 5 CFR 250.202 - Office of Personnel Management responsibilities.

    Science.gov (United States)

    2010-01-01

    ... REGULATIONS PERSONNEL MANAGEMENT IN AGENCIES Strategic Human Capital Management § 250.202 Office of Personnel... to which human capital management strategies are integrated into agency strategic plans and..., managers and human resources officers accountable for efficient and effective human capital management, in...

  18. 30 CFR 250.252 - What environmental monitoring information must accompany the DPP or DOCD?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What environmental monitoring information must accompany the DPP or DOCD? 250.252 Section 250.252 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT... incidental take of marine mammals as may be necessary under the MMPA. (c) Flower Garden Banks National Marine...

  19. The N250 brain potential to personally familiar and newly learned faces and objects

    Directory of Open Access Journals (Sweden)

    Lara Justine Pierce

    2011-10-01

    Full Text Available Studies employing event-related potentials (ERPs have shown that when participants are monitoring for a novel target face, the presentation of their own face elicits an enhanced negative brain potential in posterior channels approximately 250 ms after stimulus onset. Here, we investigate whether the own-face N250 effect generalizes to other highly familiar objects, specifically, images of the participant’s own dog and own car. In our experiments, participants were asked to monitor for a pre-experimentally unfamiliar target face (Joe, a target dog (Experiment 1: Joe’s Dog or a target car (Experiment 2: Joe’s Car. The target face and object stimuli were presented with non-target foils that included novel face and object stimuli, the participant’s own face, their own dog (Experiment 1 and their own car (Experiment 2. The consistent findings across the two experiments were the following: 1 the N250 potential differentiated the target faces and objects from the non-target face and object foils and 2 despite being non-targets, the own face and own objects produced an N250 response that was equal in magnitude to the target faces and objects by the end of the experiment. Thus, as indicated by its response to personally familiar and recently familiarized faces and objects, the N250 component is a sensitive index of individuated representations in visual memory.

  20. The Varian MAT-250 mass spectrometer. Steady isotopes laboratory

    International Nuclear Information System (INIS)

    Hernandez M, V.; Tavera D, M.L.

    1997-01-01

    This work treats over the performance and applications of the Varian Mat-250 mass spectrometer which is in the environmental isotope laboratory. It can be applied over topics such as: ions formation, acceleration and collimation, ions separation, ions detection, data transformation, sampling, δ notation. (Author)

  1. 250 kV aim for hvdc valves

    Energy Technology Data Exchange (ETDEWEB)

    1966-06-01

    Development now being carried out by ASEA is aimed at increasing the normal operating voltage for a mercury arc valve to 250 kV dc. The maximum direct voltage per valve group, with one valve in each arm of the bridge, is 125 kV for equipment already in operation in New Zealand, Japan, and Konti Scan. Valves for 130 kV and 133 kV operation are under construction for the Vancouver and the Pacific Intertie 1 links.

  2. Characteristics and uses of a 250 kW TRIGA reactor

    International Nuclear Information System (INIS)

    Dimic, V.

    1985-01-01

    The 250 kW TRIGA Mark II reactor is a light water reactor with solid fuel elements in which the zirconium hydride moderator is homogeneously distributed between enriched uranium. Therefore the reactor has the large prompt negative temperature coefficient of reactivity, the fuel also has very high retention of radioactive fission products. The reactor core is a cylindrical configuration with an annular graphite reflector. The experimental facilities include a rotary specimen rack, a central incore radiation thimble, a pneumatic transfer system, and pulsing capability. Other experimental facilities include two radial and two tangential beam tubes, a graphite thermal column, and a graphite thermalizing column. At the steady state power of 250 kW the peak flux is 1x10 13 n/cm 2 s in the central test position. In addition, pulsing to about 2000 MW is usually provided giving peak fluxes of about 2x10 16 n/cm 2 sec. All TRIGA reactors produce a core-average thermal neutron flux of about 10 7 n.v per watt. Only with very large accelerators could such a high neutron flux be achieved. In order to give an appreciation for the research conducted at research reactors, the types of research could be summarized as follows: thermal neutron scattering, neutron radiography, neutron and nuclear physics, activation analysis, radiochemistry, biology and medicine, and teaching and training. Typical applied research with a 250 kW reactor has been conducted in medicine in biology, archeology, metallurgy and materials science, engineering and criminology. It is well known that research reactors have been used routinely to produce isotopes for industry and medicine. In some instances, reactors are the preferred method of isotope production. We can conclude that the 250 kW TRIGA research reactor is a useful and wide ranging source of radiation for basic and applied research. The operation cost for this instrument is relatively low. (author)

  3. 7 CFR 250.62 - Summer Food Service Program (SFSP).

    Science.gov (United States)

    2010-01-01

    ....62 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE... Program (NSLP) and Other Child Nutrition Programs § 250.62 Summer Food Service Program (SFSP). (a... eligible for donated food support, in accordance with 7 CFR part 225. (c) Distribution of donated foods to...

  4. Behavior Characteristics of Type I (75/25) Octol during Melt Pouring HE Warhead M250 (Chaparral)

    Science.gov (United States)

    1979-09-01

    COVERED BEHAVIOR CHARACTERISTICS OF TYPE 1 (75/25) "OCTOL DURING MELT POURING HE WARHEAD I M250 (CHAPARRAL) 6. PERFORMING ORG. APrPORT NUMBER 7. AUTHOR...Military Specification, HMX, MIL-H-45444B, Amendment 2, dated 12 July 1977. 4 6. Military Specification, Warhead, Guided Missile, HE, M250 , Loading...CHARACTERISTICS OF TYPE i (75/25) OCTOL DURING MELT POURING HE WARHEAD M250 (CHAPARRAL) HERMAN J. FRIGAND SEPTEMBER 1979 US ARMY ARMAMENT RESEARCH AND

  5. 41 CFR 61-250.99 - What is the OMB control number for this part?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true What is the OMB control... TRAINING SERVICE, DEPARTMENT OF LABOR 250-ANNUAL REPORT FROM FEDERAL CONTRACTORS § 61-250.99 What is the OMB control number for this part? Pursuant to the Paperwork Reduction Act, 44 U.S.C. 3501 et seq., and...

  6. 30 CFR 250.104 - How may I appeal a decision made under MMS regulations?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How may I appeal a decision made under MMS... of Terms § 250.104 How may I appeal a decision made under MMS regulations? To appeal orders or decisions issued under MMS regulations in 30 CFR parts 250 to 282, follow the procedures in 30 CFR part 290. ...

  7. Shared technologies in the development of the Titan 250 trademark gas turbine system; Anwendung bewaehrter Technologien bei der Entwicklung des Titan 250 trademark Gasturbinensystems

    Energy Technology Data Exchange (ETDEWEB)

    Stang, Ulrich; Knodle, Mark; Novaresi, Mark [Solar Turbines, Inc., San Diego, CA (United States); Ottoboni, Luigi [Turbomach SA, Riazzino (Switzerland)

    2010-07-01

    The Titan 250 gas turbine and C85 centrifugal gas compressor are the latest additions to the Solar Turbines product family. These new products leverage core technologies that have been developed and proven in several other well-established products. The Titan 250 gas turbine is a conservative hybrid design grounded in advanced aerodynamic, thermal and mechanical design tools and methodologies. It is ISO rated at 22.4 MW (30,000 HP), with a best-in-class shaft efficiency of 40% reducing fuel costs and emissions. The engine is a two-shaft design that includes a 16-stage axial flow compressor (PR 24:1), a dry low emissions combustor (<15 ppmv NOx), a two-stage gas producer turbine operating at a firing temperature of 1200 C (2200 F), and a three-stage, maximum efficiency, fully shrouded power turbine. (orig.)

  8. 76 FR 41041 - Special Conditions: Gulfstream Aerospace LP (GALP) Model G250 Airplane, Interaction of Systems...

    Science.gov (United States)

    2011-07-13

    ... Conditions No. 25-439-SC] Special Conditions: Gulfstream Aerospace LP (GALP) Model G250 Airplane, Interaction... special conditions are issued for the Gulfstream Aerospace LP (GALP) Model G250 airplane. This airplane...

  9. Generation of chimeric bispecific G250/anti-CD3 monoclonal antibody, a tool to combat renal cell carcinoma

    NARCIS (Netherlands)

    Luiten, R. M.; Coney, L. R.; Fleuren, G. J.; Warnaar, S. O.; Litvinov, S. V.

    1996-01-01

    The monoclonal antibody (MAb) G250 binds to a tumour-associated antigen, expressed in renal cell carcinoma (RCC), which has been demonstrated to be a suitable target for antibody-mediated immunotherapy. A bispecific antibody having both G250 and anti-CD3 specificity can cross-link G250

  10. 30 CFR 250.1016 - Granting pipeline rights-of-way.

    Science.gov (United States)

    2010-07-01

    ... Section 250.1016 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL... process, for the assessment and management of OCS oil and gas transportation. (b) Should the proposed... comments. (d) If a proposed right-of-way crosses any lands not subject to disposition by mineral leasing or...

  11. 43 CFR 17.250 - Health, welfare, and social services.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Health, welfare, and social services. 17... § 17.250 Health, welfare, and social services. This subpart applies to health, welfare, and other...) General. In providing health, welfare, or other social services or benefits, a recipient may not, on the...

  12. 17 CFR 250.44 - Sales of securities and assets.

    Science.gov (United States)

    2010-04-01

    ... not require prior Commission approval. (c) Sales pursuant to order or plan under section 11. No... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Sales of securities and assets... Various Financial Transactions 2 § 250.44 Sales of securities and assets. (a) Sales of utility securities...

  13. Ford F250 Dedicated CNG Pickup

    International Nuclear Information System (INIS)

    Eudy, Leslie

    1999-01-01

    The U.S. Department of Energy (DOE) is encouraging the use of alternative fuels and alternative fuel vehicles (AFVs). To support this activity, DOE has directed the National Renewable Energy Laboratory (NREL) to conduct projects to evaluate the performance and acceptability of light-duty AFVs. In this study, we tested a pair of 1998 Ford F-250 pickups: one dedicated compressed natural gas (CNG) model and a gasoline model as closely matched as possible. Each vehicle was run through a series of tests to evaluate acceleration, fuel economy, braking, and cold-start capabilities, as well as more subjective performance indicators such as handling, climate control, and noise

  14. 30 CFR 250.116 - How do I determine producibility if my well is in the Gulf of Mexico?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I determine producibility if my well is in the Gulf of Mexico? 250.116 Section 250.116 Mineral Resources MINERALS MANAGEMENT SERVICE... Performance Standards § 250.116 How do I determine producibility if my well is in the Gulf of Mexico? If your...

  15. Radiation from a hot, thin plasma from 1 to 250 A

    International Nuclear Information System (INIS)

    Kato, T.

    1976-01-01

    A calculation of emission spectrum of a hot, low-density plasma in the region 1--250 A is presented. The mechanisms considered are electron collision-induced line emission, bremsstrahlung, and radiative recombination; and the temperature range studied is 10 5 --10 7 K. 795 lines are included. The elemental abundances of the ions of He, C, N, O, Ne, Mg, Si, S, Ca, Fe, and Ni were taken to be as in the solar corona. The line emission of Fe ions produces a maximum in the curve of an emission power between 1 and 250 A versus temperature around 10 6 K. The emission rate around 10 6 K is larger than the results calculated by Cox and Tucker and Tucker and Koren

  16. CANDU-BLW-250

    Energy Technology Data Exchange (ETDEWEB)

    Pon, G A

    1967-09-15

    The plant 'La Centrale nucleaire de Gentilly' is located between Montreal and Quebec City on the south shore of the St. Lawrence River and start-up is scheduled for 1971. A CANDU-BLW reactor is the nuclear steam generator. his reactor utilizes a heavy water moderator, natural uranium oxide fuel, and a boiling light water coolant. To be economic, this type of plant must have a minimum light water inventory in the reactor core. A minimum inventory is obtained (a) by reducing the cross-sectional area for coolant flow to a minimum, and (b) by operating at a low-coolant density. In CANDU-BLW-250, this is accomplished by operating a closed spaced fuel rod bundle at high steam quality. These features and others in the BLW concept lead to a number of areas of concern and they are summarized below: (1) Heat Transfer: It is intended that under normal operating conditions the fuel sheaths will always be wetted with coolant. (ii) Hydrodynamic Stability: Experiments and analysis indicate that the plant has a considerable over-power capacity before instability is predicted. (iii) Control: This plant does have a positive power coefficient and the transient performance with various disturbances are detailed. (iv) Safety: The positive power coefficient leads to concern over the loss of coolant accident. The results of some accident analysis are presented. (author)

  17. 50 CFR 216.250 - Specified activity and specified geographical region.

    Science.gov (United States)

    2010-10-01

    ... OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS Taking Marine Mammals Incidental to Conducting Precision Strike Weapon Missions in the Gulf of Mexico § 216.250 Specified activity and specified geographical region. (a...

  18. CEP250 mutations associated with mild cone-rod dystrophy and sensorineural hearing loss in a Japanese family.

    Science.gov (United States)

    Kubota, Daiki; Gocho, Kiyoko; Kikuchi, Sachiko; Akeo, Keiichiro; Miura, Masahiro; Yamaki, Kunihiko; Takahashi, Hiroshi; Kameya, Shuhei

    2018-05-02

    CEP250 encodes the C-Nap1 protein which belongs to the CEP family of proteins. C-Nap1 has been reported to be expressed in the photoreceptor cilia and is known to interact with other ciliary proteins. Mutations of CEP250 cause atypical Usher syndrome which is characterized by early-onset sensorineural hearing loss (SNHL) and a relatively mild retinitis pigmentosa. This study tested the hypothesis that the mild cone-rod dystrophy (CRD) and SNHL in a non-consanguineous Japanese family was caused by CEP250 mutations. Detailed ophthalmic and auditory examinations were performed on the proband and her family members. Whole exome sequencing (WES) was used on the DNA obtained from the proband. Electrophysiological analysis revealed a mild CRD in two family members. Adaptive optics (AO) imaging showed reduced cone density around the fovea. Auditory examinations showed a slight SNHL in both patients. WES of the proband identified compound heterozygous variants c.361C>T, p.R121*, and c.562C>T, p.R188* in CEP250. The variants were found to co-segregate with the disease in five members of the family. The variants of CEP250 are both null variants and according to American College of Medical Genetics and Genomics (ACMG) standards and guideline, these variants are classified into the very strong category (PVS1). The criteria for both alleles will be pathogenic. Our data indicate that mutations of CEP250 can cause mild CRD and SNHL in Japanese patients. Because the ophthalmological phenotypes were very mild, high-resolution retinal imaging analysis, such as AO, will be helpful in diagnosing CEP250-associated disease.

  19. Characterization of Aging Behavior in M250 Grade Maraging Steel Using Ultrasonic Measurements

    Science.gov (United States)

    Rajkumar, K. V.; Kumar, Anish; Jayakumar, T.; Raj, Baldev; Ray, K. K.

    2007-02-01

    Ultrasonic measurements have been carried out in M250 grade maraging steel specimens subjected to solution annealing at 1093 K for 1 hour followed by aging at 755 K for various durations in the range of 0.25 to 100 hours. The influence of aging on microstructure, room temperature hardness, and ultrasonic parameters (longitudinal and shear wave velocities and Poisson’s ratio) has been studied in order to derive correlations among these parameters in aged M250 maraging steel. Both hardness and ultrasonic velocities exhibit almost similar behaviors with aging time. They increase with the precipitation of intermetallic phases, Ni3Ti and Fe2Mo, and decrease with the reversion of martensite to austenite. Ultrasonic shear wave velocity is found to be more influenced by the precipitation of intermetallic phases, whereas longitudinal wave velocity is influenced more by the reversion of martensite to austenite. Unlike hardness and ultrasonic velocities, the Poisson’s ratio exhibits a monotonous decrease with aging time and, hence, can be used for unambiguous monitoring of the aging process in M250 maraging steel. Further, none of the parameters, i.e., hardness, ultrasonic velocity, or Poisson’s ratio, alone could identify the initiation of the reversion of austenite at early stage; however, the same could be identified from the correlation between ultrasonic velocity and Poisson’s ratio, indicating the advantage of using the multiparametric approach for comprehensive characterization of complex aging behavior in M250 grade maraging steel.

  20. On rolling of alloyed steels on the continuous light-section mill 250

    International Nuclear Information System (INIS)

    Grigor'ev, V.K.; Antipov, V.F.; Zamotin, V.M.; Kuznetsov, Yu.M.

    1976-01-01

    Using the method of computed ratios, the expected loads (torques) have been calculated in the rolling of alloyed steels on the light-section mill 250 of the Chelyabinsk metallurgical works. The deviation of the computed torques from those measured for steels 35GS and St5ps does not exceed -6%. Data are given on changes in torques during the rolling of alloyed steels in the different stands as compared with the actual data for the rolling of ordinary steel. Calculations show, and experimental data confirm, that, according to the torque value, it is possible to roll alloyed steels of sufficiently wide assortment on mill 250

  1. 21 CFR 250.108 - Potassium permanganate preparations as prescription drugs.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Potassium permanganate preparations as... or Prescription Status of Specific Drugs § 250.108 Potassium permanganate preparations as... women resulting from the misuse of potassium permanganate in an effort to induce abortion. Reports from...

  2. Production of charmonium in 250 GeV μ+-iron interactions

    International Nuclear Information System (INIS)

    Aubert, J.J.; Dobinson, R.W.; Dosselli, U.; Edwards, A.; Gabathuler, E.; Gregory, P.; Haas, J.; Leenen, M.; Montgomery, H.E.; Osborne, A.M.; Bassompierre, G.; Bouard, X. de; Broll, C.; Coignet, G.; Crespo, J.M.; Declais, Y.; Favier, J.; Maire, M.; Massonnet, L.; Minssieux, H.; Payre, P.; Pessard, H.; Schneegans, M.; Thenard, J.M.; Urban, L.; Becks, K.H.; Boehm, E.; Brown, S.; Cobb, J.H.; Combley, F.; D'Agostini, G.; Dalpiaz, P.F.; Dalpiaz, P.; Dau, W.D.; Davies, J.K.; Drees, J.; Ferrero, M.I.; Gamet, R.; Gerhardt, V.; Hamacher, K.; Hayman, P.; Henckes, M.; Landgraf, U.; Mohr, W.; Moser, K.; Mount, R.P.; McNicholas, J.; Peroni, C.; Pietrzyk, U.; Rith, K.; Sloan, T.; Stier, H.E.; Stockhausen, W.; Villers, M.; Wahlen, H.; Whalley, M.; Williams, D.; Williams, W.S.C.; Williamson, J.; Wimpenny, S.J.

    1983-01-01

    The production of J/psi and psi' has been measured in 250 GeV muon iron interactions. The measured total cross sections are sigma(μN-> μJ/psiX) = 0.74 +- 0.14 nb and sigma (μN->μpsi'X) =0.16 +-. (orig.)

  3. 75 FR 62919 - Notice of Final Federal Agency Actions on the Route 250 Bypass Interchange at McIntire Road...

    Science.gov (United States)

    2010-10-13

    ... on the Route 250 Bypass Interchange at McIntire Road Project in Virginia AGENCY: Federal Highway.... 139(l)(1). The actions relate to the Route 250 Bypass Interchange at McIntire Road project in the City... Virginia: Route 250 Bypass Interchange at McIntire Road. The project would involve construction of a grade...

  4. 20 CFR 410.250 - Effect of conviction of felonious and intentional homicide on entitlement to benefits.

    Science.gov (United States)

    2010-04-01

    ... intentional homicide on entitlement to benefits. 410.250 Section 410.250 Employees' Benefits SOCIAL SECURITY... conviction of felonious and intentional homicide on entitlement to benefits. An individual who has been finally convicted by a court of competent jurisdiction of the felonious and intentional homicide of a...

  5. 30 CFR 250.213 - What general information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... description and discussion of any new or unusual technology (see definition under § 250.200) you will use to... hydrocarbons. Include the estimated flow rate, total volume, and maximum duration of the potential blowout...

  6. 30 CFR 250.191 - How does MMS conduct incident investigations?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How does MMS conduct incident investigations... Reporting Requirements § 250.191 How does MMS conduct incident investigations? Any investigation that MMS... meetings conducted by a chairperson appointed by MMS. The following requirements apply to any panel...

  7. 76 FR 25229 - Special Conditions: Gulfstream Aerospace LP (GALP) Model G250 Airplane, Dynamic Test Requirements...

    Science.gov (United States)

    2011-05-04

    ... Memorandum ``Side-Facing Seats on Transport Category Airplanes'' and draft Issue Paper ``Dynamic Test...; Special Conditions No. 25-425-SC] Special Conditions: Gulfstream Aerospace LP (GALP) Model G250 Airplane... are issued for the Gulfstream Aerospace LP (GALP) model G250 airplane. This airplane will have a novel...

  8. 30 CFR 250.523 - How long do I keep records of casing pressure and diagnostic tests?

    Science.gov (United States)

    2010-07-01

    ... and diagnostic tests? 250.523 Section 250.523 Mineral Resources MINERALS MANAGEMENT SERVICE... casing pressure and diagnostic tests? Records of casing pressure and diagnostic tests must be kept at the field office nearest the well for a minimum of 2 years. The last casing diagnostic test for each casing...

  9. A randomized trial of three copper IUDs (MLCu250, MLCu375 and Nova-T).

    Science.gov (United States)

    Bratt, H; Skjeldestad, F E; Cullberg Valentin, K

    1988-01-01

    A randomized prospective trial of three copper IUDs, Nova-T, MLCu375 and MLCu250, including 200 of each, is presented. Insertion was done at the hospital outpatient clinic on normally menstruating women and on women in puerperio. Follow-up was scheduled after 12, 24 and 36 months. Pregnancy rates were low for all 3 models. Pearl indices after 3 years were 0.5, 0.9 and 0.8 for Nova-T, MLCu375 and MLCu250 respectively (NS). Abnormal bleeding and/or pain was the most frequent termination cause. Minor differences in the termination rates because of abnormal bleeding and/or pain were found and are discussed. The continuation rates based on all medically relevant IUD removals were 74%, 73% and 81% after 3 years for Nova-T, MLCu375 and MLCu250 respectively. No important difference in clinical performance between the three copper IUDs could be demonstrated.

  10. 30 CFR 250.414 - What must my drilling prognosis include?

    Science.gov (United States)

    2010-07-01

    ...) Projected plans for logging; (c) Planned safe drilling margin between proposed drilling fluid weights and... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must my drilling prognosis include? 250... OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations...

  11. CANDU-BLW-250

    Energy Technology Data Exchange (ETDEWEB)

    Pon, G. A. [Atomic Energy of Canada Ltd, Sheridan Park, ON (Canada)

    1968-04-15

    The plant ''La Centrale nucleaire de Gentiliy'' is located between Montreal and Quebec City on the south shore of the St. Lawrence River. Startup is scheduled for 1971. A CANDU-BLW reactor is the nuclear steam generator. This reactor utilizes a heavy-water moderator, natural uranium oxide fuel, and a boiling light-water coolant. To be economic, this type of plant must have a minimum light-water inventory in the reactor core. A minimum inventory is obtained (a) by reducing the cross-sectional area for coolant flow to a minimum, and (b) by operating at a low coolant density. In CANDU-BLW-250, this is accomplished by operating a closed spaced fuel rod bundle at high steam quality. These features and others in the BLW concept lead to a number of areas of concern and they are summarized below: (i) Heat transfer. It is intended that under normal operating conditions the fuel sheaths will always be wetted with coolant. Some experiments and backup calculations are presented to support this specification. (ii) Hydrodynamic stability. Experiments and analysis indicate that the plant has a considerable over-power capacity before instability is predicted. (iii) Control. This plant does have a positive power coefficient and the transient performance with various disturbances is detailed. (iv) Safety. The positive power coefficient leads to concern over the loss of coolant accident. The results of some accident analyses are presented. (author)

  12. MHD repowering of a 250 MWe unit of the TVA Allen Steam Plant

    International Nuclear Information System (INIS)

    Chapman, J.N.; Attig, R.C.

    1992-01-01

    In this paper coal fired MHD repowering is considered for the TVA Allen Steam Plant. The performance of the repowered plant is presented. Cost comparisons are made of the cost of repowering with MHD versus the cost of meeting similar standards by installing scrubbers and selective catalytic NO x reduction (SCNR). For repowering of a single 250 MW e unit, the costs favor scrubbing and SCNR. If one considers a single repowering of all three 250 MW e units by a single MHD topping cycle and boiler, MHD repowering is more economical. Environmental emissions from the repowered plant are estimated

  13. 30 CFR 250.187 - What are MMS' incident reporting requirements?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are MMS' incident reporting requirements... Reporting Requirements § 250.187 What are MMS' incident reporting requirements? (a) You must report all... other permit issued by MMS, and that are related to operations resulting from the exercise of your...

  14. 30 CFR 250.119 - Will MMS approve subsurface gas storage?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Will MMS approve subsurface gas storage? 250....119 Will MMS approve subsurface gas storage? The Regional Supervisor may authorize subsurface storage of gas on the OCS, on and off-lease, for later commercial benefit. To receive MMS approval you must...

  15. Binary energy source of the HH 250 outflow and its circumstellar environment

    Science.gov (United States)

    Comerón, Fernando; Reipurth, Bo; Yen, Hsi-Wei; Connelley, Michael S.

    2018-04-01

    Aims: Herbig-Haro flows are signposts of recent major accretion and outflow episodes. We aim to determine the nature and properties of the little-known outflow source HH 250-IRS, which is embedded in the Aquila clouds. Methods: We have obtained adaptive optics-assisted L-band images with the NACO instrument on the Very Large Telescope (VLT), together with N- and Q-band imaging with VISIR also on the VLT. Using the SINFONI instrument on the VLT we carried out H- and K-band integral field spectroscopy of HH 250-IRS, complemented with spectra obtained with the SpeX instrument at the InfraRed Telescope Facility (IRTF) in the JHKL bands. Finally, the SubMillimeter Array (SMA) interferometer was used to study the circumstellar environment of HH 250-IRS at 225 and 351 GHz with CO (2-1) and CO (3-2) maps and 0.9 mm and 1.3 mm continuum images. Results: The HH 250-IRS source is resolved into a binary with 0.''53 separation, corresponding to 120 AU at the adopted distance of 225 pc. The individual components show heavily veiled spectra with weak CO absorption indicative of late-type stars. Both are Class I sources, but their spectral energy distributions between 1.5 μm and 19 μm differ markedly and suggest the existence of a large cavity around one of the components. The millimeter interferometric observations indicate that the gas mainly traces a circumbinary envelope or disk, while the dust emission is dominated by one of the circumstellar envelopes. Conclusions: HH 250-IRS is a new addition to the handful of multiple systems where the individual stellar components, the circumstellar disks and a circumbinary disk can be studied in detail, and a rare case among those systems in which a Herbig-Haro flow is present. Based on observations obtained with the VLT (Cerro Paranal, Chile) in programs 089.C-0196(A), 095.C-0488(A), and 095.C-0488(B), as well as with IRTF (Mauna Kea, Hawaii), SMA (Mauna Kea, Hawaii), and the Nordic Optical Telescope (La Palma, Canary Islands, Spain

  16. 30 CFR 250.261 - What environmental impact analysis (EIA) information must accompany the DPP or DOCD?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What environmental impact analysis (EIA) information must accompany the DPP or DOCD? 250.261 Section 250.261 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Plans and Information Contents of...

  17. Oral administration of type-II collagen peptide 250-270 suppresses specific cellular and humoral immune response in collagen-induced arthritis.

    Science.gov (United States)

    Zhu, Ping; Li, Xiao-Yan; Wang, Hong-Kun; Jia, Jun-Feng; Zheng, Zhao-Hui; Ding, Jin; Fan, Chun-Mei

    2007-01-01

    Oral antigen is an attractive approach for the treatment of autoimmune and inflammatory diseases. Establishment of immune markers and methods in evaluating the effects of antigen-specific cellular and humoral immune responses will help the application of oral tolerance in the treatment of human diseases. The present article observed the effects of chicken collagen II (CII), the recombinant polymerized human collagen II 250-270 (rhCII 250-270) peptide and synthesized human CII 250-270 (syCII 250-270) peptide on the induction of antigen-specific autoimmune response in rheumatoid arthritis (RA) peripheral blood mononuclear cells (PBMC) and on the specific cellular and humoral immune response in collagen-induced arthritis (CIA) and mice fed with CII (250-270) prior to immunization with CII. In the study, proliferation, activation and intracellular cytokine production of antigen-specific T lymphocytes were simultaneously analyzed by bromodeoxyuridine (BrdU) incorporation and flow cytometry at the single-cell level. The antigen-specific antibody and antibody-forming cells were detected by ELISA and ELISPOT, respectively. CII (250-270) was found to have stimulated the response of specific lymphocytes in PBMC from RA patients, including the increase expression of surface activation antigen marker CD69 and CD25, and DNA synthesis. Mice, fed with CII (250-270) before CII immunization, had significantly lower arthritic scores than the mice immunized with CII alone, and the body weight of the former increased during the study period. Furthermore, the specific T cell activity, proliferation and secretion of interferon (IFN)-gamma in spleen cells were actively suppressed in CII (250-270)-fed mice, and the serum anti-CII, anti-CII (250-270) antibody activities and the frequency of specific antibody-forming spleen cells were significantly lower in CII (250-270)-fed mice than in mice immunized with CII alone. These observations suggest that oral administration of CII (250-270) can

  18. The discovery of 260Md and the decay properties of 258Fm, 258m,gMd and 259Md

    International Nuclear Information System (INIS)

    Lougheed, R.W.; Hulet, E.K.; Dougan, R.J.; Wild, J.F.; Dupzyk, R.J.; Henderson, C.M.; Moody, K.J.; Hahn, R.L.; Suemmerer, K.; Bethune, G.

    1986-01-01

    We have discovered a new neutron-rich isotope, 260 Md, from 18 O and 22 Ne bombardments of 254 Es. We observed a spontaneous-fission (SF) activity with a half-life of 32 days in electromagnetically separated fractions with mass number 260 from these bombardments and we measured the mass and kinetic energy distributions of this SF activity. The mass distribution was symmetric with the principal energy peak at a total kinetic energy (TKE) of 234 MeV, similar to previous observations for heavy fermium isotopes. Surprisingly, we also observed a smaller symmetric component with a TKE of 195 MeV. We interpret these two peaks in the TKE distribution as arising from two types of fission in the same nucleus, or bimodal fission. The observed fission activity may be either from the SF decay of 260 Md or from 260 Fm which would arise from electron-capture (EC) decay of 260 Md. We have eliminated the possible β - decay of 260 Md by measuring β - -SF time correlations for the decay of 260 Md and we plan to determine whether 260 Md decays by EC by measuring time correlations between fermium X-rays and SF events. We also measured various properties of the heavy fermium and mendelevium isotopes and obtained 1. more accurate cross-sections for the neutron-rich mendelevium isotopes which we use to predict the production rates of yet undiscovered nuclides, 2. improved half-life measurements for 258m,g Md and 259 Md, 3. confirmation of the EC decay of 258m Md by measurement of the fermium X-rays preceding the SF decay of 258 Fm and 4. very substantially improved mass and TKE distributions for the SF decay of 258 Fm and 259 Md. (orig.)

  19. 30 CFR 250.1507 - How will MMS measure training results?

    Science.gov (United States)

    2010-07-01

    ... program, using one or more of the methods in this section. (a) Training system audit. MMS or its... how effective the training was. (c) Employee or contract personnel testing. MMS or its authorized... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How will MMS measure training results? 250.1507...

  20. Mechanical design of a 250 kilogauss solenoidal magnet

    International Nuclear Information System (INIS)

    Bonanos, P.

    1975-12-01

    The mechanical design and construction of a 5 cm bore, 23 cm long solenoidal magnet operated at 250 kilogauss is described. The magnet provides confining field for a plasma heated by a CO 2 laser. Radial diagnostic ports with a clear aperture of 0.41 cm allow viewing access near the magnet midplane. The on-axis field homogeneity is within 5 percent over a central length of 12 cm. The magnet sustained 500 to 1000 pulses at the highest field levels before catastrophic failure

  1. A Theoretical and Experimental Analysis of Post-Compression Water Injection in a Rolls-Royce M250 Gas Turbine Engine

    Science.gov (United States)

    2015-05-18

    ROLLS-ROYCE M250 GAS TURBINE ENGINE by Midshipman 1/C Brian R. He United States Naval Academy Annapolis, Maryland...Injection in a Rolls- Royce M250 Gas Turbine Engine 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) He...output, efficiency, operating conditions, and emissions of injecting water at the compressor discharge of a Rolls-Royce M250 . The results

  2. Towards 250 m mapping of terrestrial primary productivity over Canada

    Science.gov (United States)

    Gonsamo, A.; Chen, J. M.

    2011-12-01

    Terrestrial ecosystems are an important part of the climate and global change systems. Their role in climate change and in the global carbon cycle is yet to be well understood. Dataset from satellite earth observation, coupled with numerical models provide the unique tools for monitoring the spatial and temporal dynamics of territorial carbon cycle. The Boreal Ecosystems Productivity Simulator (BEPS) is a remote sensing based approach to quantifying the terrestrial carbon cycle by that gross and net primary productivity (GPP and NPP) and terrestrial carbon sinks and sources expressed as net ecosystem productivity (NEP). We have currently implemented a scheme to map the GPP, NPP and NEP at 250 m for first time over Canada using BEPS model. This is supplemented by improved mapping of land cover and leaf area index (LAI) at 250 m over Canada from MODIS satellite dataset. The results from BEPS are compared with MODIS GPP product and further evaluated with estimated LAI from various sources to evaluate if the results capture the trend in amount of photosynthetic biomass distributions. Final evaluation will be to validate both BEPS and MODIS primary productivity estimates over the Fluxnet sites over Canada. The primary evaluation indicate that BEPS GPP estimates capture the over storey LAI variations over Canada very well compared to MODIS GPP estimates. There is a large offset of MODIS GPP, over-estimating the lower GPP value compared to BEPS GPP estimates. These variations will further be validated based on the measured values from the Fluxnet tower measurements over Canadian. The high resolution GPP (NPP) products at 250 m will further be used to scale the outputs between different ecosystem productivity models, in our case the Canadian carbon budget model of Canadian forest sector CBM-CFS) and the Integrated Terrestrial Ecosystem Carbon model (InTEC).

  3. DCU 250 Arabic dependency bank: an LFG gold standard resource for the Arabic Penn treebank

    OpenAIRE

    Al-Raheb, Yafa; Akrout, Amine; van Genabith, Josef; Dichy, J.

    2006-01-01

    This paper describes the construction of a dependency bank gold standard for Arabic, DCU 250 Arabic Dependency Bank (DCU 250), based on the Arabic Penn Treebank Corpus (ATB) (Bies and Maamouri, 2003; Maamouri and Bies, 2004) within the theoretical framework of Lexical Functional Grammar (LFG). For parsing and automatically extracting grammatical and lexical resources from treebanks, it is necessary to evaluate against established gold standard resources. Gold standards for various languages h...

  4. On the economic dimensions of CSR: Exploring Fortune Global 250 reports

    NARCIS (Netherlands)

    Fortanier, F.N.; Kolk, A.

    2007-01-01

    The macro-level debate on the economic impact of multinational enterprises (MNEs) is still unsettled. This article explores micro-level evidence by examining what Fortune Global 250 firms themselves report about their economic impact. Such reporting embodies corporate attempts to account for their

  5. Anti-inflammatory effects of salmeterol/fluticasone propionate 50/250 mcg combination therapy in Japanese patients with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Asai K

    2015-04-01

    Full Text Available Kazuhisa Asai,1 Akihiro Kobayashi,2 Yukio Makihara,3 Malcolm Johnson4 1Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan; 2Biomedical Data Sciences, 3Medical Affairs Respiratory Department, GlaxoSmithKline, Tokyo, Japan; 4Respiratory Global Franchise, GlaxoSmithKline, Uxbridge, UK Purpose: Using sputum neutrophils as the primary measure, and other inflammation biomarkers, this study evaluated the anti-inflammatory effects of the combination salmeterol 50 mcg and fluticasone propionate 250 mcg (SFC 250 in Japanese patients with chronic obstructive pulmonary disease (COPD. Patients and methods: Patients were treated in a randomized, double-blind, parallel group, placebo-controlled trial with SFC 250 twice daily (n=26 or placebo (n=26 for 12 weeks. At the start and end of treatment, inflammation biomarkers (sputum and serum, lung function, and health status (COPD Assessment Test [CAT] questionnaire were measured. Results: Although a numerical decrease in differential neutrophil count was observed from baseline, SFC 250 did not significantly reduce sputum neutrophils compared with placebo, nor were there significant changes from baseline in the other biomarkers (sputum or serum, lung function, or CAT, versus placebo. Squamous epithelial cell contamination in some sputum samples rendered them unacceptable for analysis, which reduced the sample size to n=19 (SFC 250 and n=10 (placebo. However, inclusion of contaminated samples did not affect the overall trend of the outcome. Ad hoc bootstrap statistical analysis showed a 27.9% (SFC 250 and 1.3% (placebo decrease in sputum neutrophils. Sputum IL-8 decreased by 43.2% after SFC 250 but increased by 48.3% with placebo. Responder analyses showed 42% of patients had ≥20% decrease in neutrophils from baseline; and 47% of patients had a ≥200 pg/mL change in sputum IL-8 following SFC 250 versus 20% after placebo; both changes are considered clinically

  6. Search for charm in 250 GeV/c π-p interactions

    International Nuclear Information System (INIS)

    Bogert, D.; Hanft, R.; Albright, J.R.

    1975-10-01

    A study was made of the reaction π - + p at 250 GeV/c in order to search for charmed particles. Cross sections, effective mass distributions, and an upper limit for each decay mode were found. However, no evidence was found for charmed particles

  7. Efficient high-throughput biological process characterization: Definitive screening design with the ambr250 bioreactor system.

    Science.gov (United States)

    Tai, Mitchell; Ly, Amanda; Leung, Inne; Nayar, Gautam

    2015-01-01

    The burgeoning pipeline for new biologic drugs has increased the need for high-throughput process characterization to efficiently use process development resources. Breakthroughs in highly automated and parallelized upstream process development have led to technologies such as the 250-mL automated mini bioreactor (ambr250™) system. Furthermore, developments in modern design of experiments (DoE) have promoted the use of definitive screening design (DSD) as an efficient method to combine factor screening and characterization. Here we utilize the 24-bioreactor ambr250™ system with 10-factor DSD to demonstrate a systematic experimental workflow to efficiently characterize an Escherichia coli (E. coli) fermentation process for recombinant protein production. The generated process model is further validated by laboratory-scale experiments and shows how the strategy is useful for quality by design (QbD) approaches to control strategies for late-stage characterization. © 2015 American Institute of Chemical Engineers.

  8. 7 CFR 250.59 - Storage and inventory management of donated foods.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Storage and inventory management of donated foods. 250... management of donated foods. (a) General requirements. Distributing agencies, subdistributing agencies, and... management system, as defined in this part, unless the distributing agency requires donated foods to be...

  9. 7 CFR 250.14 - Warehousing, distribution and storage of donated foods.

    Science.gov (United States)

    2010-01-01

    .... (iv) All initial data regarding the cost of the current warehousing and distribution system and the... 7 Agriculture 4 2010-01-01 2010-01-01 false Warehousing, distribution and storage of donated foods... General Operating Provisions § 250.14 Warehousing, distribution and storage of donated foods. (a...

  10. Experimental ethylene oxide neuropathy. Chronic exposure to 250 ppm in rats

    Energy Technology Data Exchange (ETDEWEB)

    Ohnishi, A.; Yamamoto, T.; Inoue, N.; Tanaka, I.; Koga, M.

    1985-12-01

    In Wistar rats subjected to a six-hour exposure to ethylene oxide (ETO) at the concentration of 250 parts per million once a day, five times a week for 9 months, histopathologic studies of myelinated fibers of the proximal sural, distal sural and peroneal nerves and of the fasciculus gracilis at the fifth thoracic and third cervical segments of the spinal cord were performed to reveal whether ETO of such concentration produces the degeneration of the primary sensory neuron. Throughout the study, no definite abnormality of the gait or posture was observed in both control and test rats. Qualitative histologic studies disclosed preferential distal axonal degeneration of myelinated fibers in both sural nerves and gracile fascicles in test rats, although the extent of the distribution and the severity of the degenerative findings were variable among test rats. Therefore, it was concluded that exposure to 250 ppm ethylene oxide produces central-peripheral distal axonal degeneration of the primary sensory neuron in rats.

  11. 12 CFR 250.402 - Service as officer, director, or employee of licensee corporation under the Small Business...

    Science.gov (United States)

    2010-01-01

    ... licensee corporation under the Small Business Investment Act of 1958. 250.402 Section 250.402 Banks and... employee of licensee corporation under the Small Business Investment Act of 1958. (a) The Board of... corporation under the Small Business Investment Act of 1958 (15 U.S.C. 661 et seq.). It is understood that a...

  12. Evaluation of the Meditech M250 and a comparison with other CT scanners

    Energy Technology Data Exchange (ETDEWEB)

    Greensmith, R.; Richardson, R.B.; Mackintosh, I.P.; Sargood, A.J.; Stevens, P.H.

    1985-11-01

    The Meditech M250 computerised tomography (CT) machine was evaluated during the first half of 1984. Measurements were made of noise, modulation transfer function, slice width, radiation dose profile, uniformity and linearity of CT number, effective photon energy and parameters relating to machine specification, such as pixel size and scan time. All breakdowns were logged to indicate machine reliability. A comparison with the established EMI CT1010 and CT5005 was made for noise, resolution and multislice radiation dose, as well as the dose efficiency or quality (Q) factor for both head and body modes of operation. The M250 was found to perform to its intended specification with an acceptable level of reliability.

  13. 30 CFR 250.901 - What industry standards must your platform meet?

    Science.gov (United States)

    2010-07-01

    ...) American Petroleum Institute (API) Bulletin 2INT-DG, Interim Guidance for Design of Offshore Structures for... (RP) 2A-WSD, RP for Planning, Designing, and Constructing Fixed Offshore Platforms—Working Stress..., (incorporated by reference as specified in § 250.198); (15) American Society for Testing and Materials (ASTM...

  14. 33 CFR 110.250 - St. Thomas Harbor, Charlotte Amalie, V.I.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false St. Thomas Harbor, Charlotte... SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.250 St. Thomas Harbor, Charlotte Amalie.... Thomas, V.I. of the United States and approaches thereto, including all waters under its jurisdiction, as...

  15. Electron beam dynamics in the LIU-30/250 accelerator

    International Nuclear Information System (INIS)

    Vakhrushin, Yu.P.; Kuznetsov, V.S.; Tikhomirov, A.S.

    1989-01-01

    Results of numerical simulation of coherent oscillations of electron beam in the LIU-30/250 accelerating system are presented. Transport systems both with continuous field and the discrete ones are considered. The following conclusions are made: amplitude of coherent oscillations inevitably grows in the real transport channel; the presence of correctors can lead to sufficient losses of beam pulse duration; discrete system is the optimal system for beam transport without sufficient losses. 7 refs.; 3 figs

  16. The Novel N-Substituted Benztropine Analog GA2-50 Possesses Pharmacokinetic and Pharmacodynamic Profiles Favorable for a Candidate Substitute Medication for Cocaine Abuse

    Science.gov (United States)

    OTHMAN, AHMED A.; NEWMAN, AMY H.; EDDINGTON, NATALIE D.

    2009-01-01

    GA2-50 is a novel N-substituted benztropine analog with improved potency and selectivity for the dopamine transporter. The pharmacokinetic and pharmacodynamic properties of GA2-50 were characterized as a part of its preclinical evaluation as a substitute medication for cocaine abuse. In vitro transport and metabolism studies as well as pharmacokinetic studies in rats were conducted. Effect of GA2-50 on the extracelluar nucleus accumbens (NAc) dopamine levels and on cocaine’s induced dopamine elevation was evaluated using intracerebral microdialysis. GA2-50 showed high transcellular permeability despite being a P-glycoprotein substrate. GA2-50 was a substrate of human CYP2D6, CYP2C19, CYP2E1, rat CYP2C11, CYP2D1, CYP3A1, and CYP1A2; with low intrinsic clearance values. In vivo, GA2-50 showed high brain uptake (Ri ~ 10), large volume of distribution (Vss =37 L/kg), and long elimination half-life (t½ =19 h). GA2-50 resulted in 1.6- and 2.7-fold dopamine elevation at the 5 and 10 mg/kg i.v. doses. Dopamine elevation induced by GA2-50 was significantly reduced, slower and longer lasting than previously observed for cocaine. GA2-50 had no significant effect on cocaine’s induced dopamine elevation upon simultaneous administration. Results from the present study indicate that GA2-50 possesses several attributes sought after for a substitute medication for cocaine abuse. PMID:18425847

  17. Estabilidad acelerada de tabletas de levodopa-carbidopa (250-25 mg

    Directory of Open Access Journals (Sweden)

    Mirna Fernández Cervera

    2001-08-01

    Full Text Available Se realizó el estudio de estabilidad acelerada de tabletas de levodopa-carbidopa (250-25 mg con el empleo de un método de cromatografía líquida de alta resolución y se comprobó su especificidad para estos fines. Se analizó la influencia de medios degradantes artificiales sobre los productos activos, además del efecto de la humedad sobre la estabilidad del producto, colocándolo en hidrostatos con humedades controladas. Este medicamento, producción nacional, cumplió con las especificaciones de calidad descritas en la USP 23 y mostró una alta estabilidad térmica.An accelerated stability study of levodopa-carbidopa tablets (250-25 mg was made using high-performance liquid chromatography which specificity for these purposes was proved. The influence of the artificial degrading media on the active products was analyzed and also the effect of humidity on the product´s satbility was examined after placing the tablets into hydrostats under controlled humidity levels. This domestically-made drug met the quality standards described in USP 23 and showed high heat stability.

  18. 30 CFR 250.113 - What procedures must I follow when welding?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What procedures must I follow when welding? 250....113 What procedures must I follow when welding? (a) Before you weld, you must move any equipment containing hydrocarbons or other flammable substances at least 35 feet horizontally from the welding area...

  19. Search for charm in 250 GeV/c π-p interactions

    International Nuclear Information System (INIS)

    Harris, R.; Bogert, D.; Hanft, R.

    1975-01-01

    Inclusive cross sections are found for strange particle production in π - p interactions at 250 GeV/c in a search for charmed particles using neutral particle decays in a bubble chamber. The results are preliminary, but at the present statistical level no evidence was found for charmed particle production

  20. 12 CFR 250.180 - Reports of changes in control of management.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Reports of changes in control of management... FEDERAL RESERVE SYSTEM MISCELLANEOUS INTERPRETATIONS Interpretations § 250.180 Reports of changes in control of management. (a) Under a statute enacted September 12, 1964 (Pub. L. 88-593; 78 Stat. 940) all...

  1. 30 CFR 250.248 - What solid and liquid wastes and discharges information and cooling water intake information must...

    Science.gov (United States)

    2010-07-01

    ... following solid and liquid wastes and discharges information and cooling water intake information must... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What solid and liquid wastes and discharges information and cooling water intake information must accompany the DPP or DOCD? 250.248 Section 250.248...

  2. 250 Years of the State Survey

    Directory of Open Access Journals (Sweden)

    Ivana Wechselberger

    2014-06-01

    Full Text Available The first topographic survey of the Habsburg Monarchy was decreed by Maria Theresa 250 years ago, on May 13, 1764. A conference was held on the occasion of the anniversary by the Austrian State Geodetic Administration (BEV – Bundesamt für Eich- und Vermessungswesen and the Institute for Military Geosciences (IMG – Institut für Militärisches Geowesen in Vienna on May 13 and 14, 2014. The conference was sort of a time travel through Austrian state surveys. Historical development and methods of the first three state surveys (18th and 19th century were presented on the first conference day. Lectures were held by representatives of Austrian scientific institutions and new countries of the Monarchy. The second conference day was dedicated to the 4th state survey (20th century and its impact on civilian and military application and economy.

  3. c-Jun binds the N terminus of human TAF(II)250 to derepress RNA polymerase II transcription in vitro.

    Science.gov (United States)

    Lively, T N; Ferguson, H A; Galasinski, S K; Seto, A G; Goodrich, J A

    2001-07-06

    c-Jun is an oncoprotein that activates transcription of many genes involved in cell growth and proliferation. We studied the mechanism of transcriptional activation by human c-Jun in a human RNA polymerase II transcription system composed of highly purified recombinant and native transcription factors. Transcriptional activation by c-Jun depends on the TATA-binding protein (TBP)-associated factor (TAF) subunits of transcription factor IID (TFIID). Protein-protein interaction assays revealed that c-Jun binds with high specificity to the largest subunit of human TFIID, TAF(II)250. The region of TAF(II)250 bound by c-Jun lies in the N-terminal 163 amino acids. This same region of TAF(II)250 binds to TBP and represses its interaction with TATA boxes, thereby decreasing DNA binding by TFIID. We hypothesized that c-Jun is capable of derepressing the effect of the TAF(II)250 N terminus on TFIID-driven transcription. In support of this hypothesis, we found that c-Jun increased levels of TFIID-driven transcription in vitro when added at high concentrations to a DNA template lacking activator protein 1 (AP-1) sites. Moreover, c-Jun blocked the repression of TBP DNA binding caused by the N terminus of TAF(II)250. In addition to revealing a mechanism by which c-Jun activates transcription, our studies provide the first evidence that an activator can bind directly to the N terminus of TAF(II)250 to derepress RNA polymerase II transcription in vitro.

  4. Tularosa, NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  5. Basic research using the 250 kW research reactor of the Jozef Stefan Institute

    International Nuclear Information System (INIS)

    Dimic, V.

    1984-01-01

    The 250 kW TRIGA Mark II reactor is a light water reactor with solid fuel elements in which the zirconium hydride moderator is homogeneously distributed between enriched uranium. The reactor therefore has a large prompt negative temperature coefficient of reactivity; the fuel also has a very high retention of radioactive fission products. The experimental facilities include a rotary specimen rack, a central in-core radiation thimble, a pneumatic transfer system and pulsing capability. Other experimental facilities include two radial and two tangential beam tubes, a graphite thermal column and a graphite thermalizing column. At the steady state power of 250 kW the peak flux is 1x10 13 n/cm 2 in the central test position. In addition, pulsing to about 2000 MW is usually provided giving peak fluxes of about 2x10 16 n/cm 2 sec. All TRIGA reactors produce a core-average thermal neutron flux of about 10 7 n.v. per watt. Only with very large accelerators can such high fluxes be achieved. The types of research could be summarized as follows: thermal neutron scattering, neutron radiography, neutron and nuclear physics, activation analysis, radiochemistry, biology and medicine, and teaching and training. Typical applied research with a 250 kW reactor has been conducted in medicine, in biology, archaeology, metallurgy and materials science, engineering and criminology. It is well known that research reactors have been used routinely to produce isotopes for industry and medicine. We can conclude that the 250 kW TRIGA reactor is a useful and wide ranging source of radiation for basic and applied research. The operation cost for this instrument is relatively low. (author)

  6. SPECT scintigraphy with HDP and Mab BW 250/183 of loosened hip endoprothesis

    Energy Technology Data Exchange (ETDEWEB)

    Predic, P [Hospital Celje, Celje (Sierra Leone); Gregoric, E [Hospital Izola, Izola (Sierra Leone); Dodig, D [Clinical Hospital Centre, Zagreb (Croatia). Dept. of Nuclear Medicine and Radiation Protection

    1994-10-01

    Main problem of the loosened hip endoprothesis is in distinguishing between the aseptic and septic loosening of endoprothesis. The study involved 27 pts with a loosened hip; 15 pts with aseptic and 12 pts with septic loosening. The patients were injected 550-770 MBq Tc-99m-HDP and underwent SPECT scintigraphy of the hips to repeat then the examination with only 370 MBq Tc-99m-Mab Bw 230/183. HDP application evidenced positive accumulation at the endoprothesis in all patients with a loosened hip while Mab Bw 250/183 only in the patients with septic loosening. Conclusion: SPECT scintigraphy of hip endoprothesis with HDP and Mab BW 250/183 allows differential diagnosing between septic and aseptic hip loosening and hereby a correct therapeutical approach. (author).

  7. 30 CFR 250.111 - Who oversees operations under my welding plan?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Who oversees operations under my welding plan... § 250.111 Who oversees operations under my welding plan? A welding supervisor or a designated person in charge must be thoroughly familiar with your welding plan. This person must ensure that each welder is...

  8. 30 CFR 250.407 - What tests must I conduct to determine reservoir characteristics?

    Science.gov (United States)

    2010-07-01

    ... Gas Drilling Operations General Requirements § 250.407 What tests must I conduct to determine... of oil, gas, sulphur, and water in the formations penetrated by logging, formation sampling, or well...

  9. Does the Loss of ARID1A (BAF-250a Expression in Endometrial Clear Cell Carcinomas Have Any Clinicopathologic Significance? A Pilot Assessment

    Directory of Open Access Journals (Sweden)

    Oluwole Fadare, Idris L. Renshaw, Sharon X. Liang

    2012-01-01

    Full Text Available SWI/SNF chromatin-modification complexes use the energy of ATP hydrolysis to remodel nucleosomes and to affect transcription and several cellular processes. Accordingly, their loss of function has been associated with malignant transformation. ARID1A (the expression of whose product, BAF250a, a key complex component, is lost when mutated has recently been identified as a tumor suppressor gene that is mutated in 46-57% of ovarian clear cell carcinoma (CCC. The purposes of this study are to assess the frequency of loss of BAF250a expression in endometrial CCC and whether this loss has any discernable clinicopathologic implications. 34 endometrial carcinomas with a CCC component (including 22 pure CCC, 8 mixed carcinomas with a 10% CCC component, and 4 carcinosarcomas with a CCC epithelial component, were evaluated by immunohistochemistry using a monoclonal antibody directed against the human BAF250a protein. 5 (22.7% of the 22 pure CCC were entirely BAF250a negative, whereas the remainder showed diffuse immunoreactivity. None of 4 carcinosarcomas and only 1 (12.5% of the 8 mixed carcinomas were BAF250a negative. There was no discernable relationship between BAF250a immunoreactivity status and tumor architectural patterns (solid, papillary or tubulocystic areas or cell type (flat, hobnail or polygonal. Of the 22 patients with pure CCC, 14, 2, 3, and 3 were International Federation of Gynecology and Obstetrics stages 1, II, III and IV respectively. Interestingly, all 5 BAF250a negative cases were late stage [stages III or IV] as compared with 1 of 17 BAF250a positive cases (p=0.0002. Thus, 83% (5/6 of all late stage cases were BAF250a [-], as compared with 0 (0% of the 16 early stage (I or II cases (p=.0002. BAF250a negative and positive cases did not show any statistically significant difference regarding patient age and frequency of lymphovascular invasion or myometrial invasion. As may be anticipated from the concentration of late stage cases in

  10. In situ stress measurements at 250m gallery off the ventilation shaft

    International Nuclear Information System (INIS)

    Nakamura, Takahiro; Sanada, Hiroyuki; Sugita, Yutaka; Kato, Harumi

    2011-06-01

    From FY2000 to FY2005, JAEA had been making research at ground surface of Horonobe town for repository of high-level radioactive waste. During this period, geological investigation, hydrogeology investigation, rock mechanics investigation, geochemical investigation using boreholes were carried out in Hokushin area which is about 3kmx3km in surface area of Horonobe town in order to construct a geological environment model and to confirm the methodology for safety assessment. Now the research program proceeds to the next stage where the underground drifts and shafts are under construction. In the underground rock mass, in situ stress is the sum of tectonic stress as well as overlying stress due to gravity. In situ stresses enter into excavation design and are required in order to predict the response of rock masses to the disturbance associated with those structures. For these reasons, JAEA has carried out in situ stress measurements using vertical boreholes drilled from ground surface to evaluate the state of horizontal stress in the area. In the research during the underground construction, comparison between the stress measurements carried out at surface and at underground is conducted. And if inconsistency between these two measurements is found, the state of stress will be updated based on more reliable information. In order to study the 3D in situ state of stress around Horonobe Underground Research Laboratory, hydraulic fracturing tests and stress relief method (Conical-ended borehole method) were conducted at the 250m gallery located near the bottom of the ventilation shaft. Three 20.0m long boreholes, 09-V250-M01(slightly upwards), 09-V250-M02(slightly upwards) and 09-V250-M03(vertical), were drilled from the gallery using 76mm diameter bit. The results of the measurements are summarized as follows: (1) Hydraulic fracturing technique. Hydraulic fracturing technique using the test equipment with sufficiently small compliance was carried out in the three

  11. Acoustic emission during tensile deformation of M250 grade maraging steel

    Science.gov (United States)

    Mukhopadhyay, Chandan Kumar; Rajkumar, Kesavan Vadivelu; Chandra Rao, Bhaghi Purna; Jayakumar, Tamanna

    2012-05-01

    Acoustic emission (AE) generated during room temperature tensile deformation of varyingly heat treated (solution annealed and thermally aged) M250 grade maraging steel specimens have been studied. Deformation of microstructure corresponding to different heat treated conditions in this steel could be distinctly characterized using the AE parameters such as RMS voltage, counts and peak amplitude of AE hits (events).

  12. Compact 250-kV injector system for PIGMI

    International Nuclear Information System (INIS)

    Hamm, R.W.; Stevens, R.R. Jr.; Mueller, D.W.; Lederer, H.M.

    1978-01-01

    A 250-kV proton injector to be used in the development of a linac suitable for medical applications has been constructed. This injector utilizes a spherical Pierce geometry to produce a converging beam. A gas insulated accelerating column is cantilevered on a grounded vacuum system, with a separate high voltage equipment dome connected to a 300-kV Cockcroft-Walton power supply. The injector can be operated locally or remotely, with the remote control accomplished by a microprocessor system linked to a central control minicomputer. This injector has been designed as a low-cost compact system. The design details and the data obtained during initial operation are presented

  13. 30 CFR 250.192 - What reports and statistics must I submit relating to a hurricane, earthquake, or other natural...

    Science.gov (United States)

    2010-07-01

    ... relating to a hurricane, earthquake, or other natural occurrence? 250.192 Section 250.192 Mineral Resources... statistics must I submit relating to a hurricane, earthquake, or other natural occurrence? (a) You must... tropical storm, or an earthquake. Statistics include facilities and rigs evacuated and the amount of...

  14. An evaluation of the Meditech M250 and a comparison with other CT scanners

    International Nuclear Information System (INIS)

    Greensmith, R.; Richardson, R.B.; Mackintosh, I.P.; Sargood, A.J.; Stevens, P.H.

    1985-01-01

    The Meditech M250 computerised tomography (CT) machine was evaluated during the first half of 1984. Measurements were made of noise, modulation transfer function, slice width, radiation dose profile, uniformity and linearity of CT number, effective photon energy and parameters relating to machine specification, such as pixel size and scan time. All breakdowns were logged to indicate machine reliability. A comparison with the established EMI CT1010 and CT5005 was made for noise, resolution and multislice radiation dose, as well as the dose efficiency or quality (Q) factor for both head and body modes of operation. The M250 was found to perform to its intended specification with an acceptable level of reliability. (author)

  15. An evaluation of the Meditech M250 and a comparison with other CT scanners.

    Science.gov (United States)

    Greensmith, R; Richardson, R B; Sargood, A J; Stevens, P H; Mackintosh, I P

    1985-11-01

    The Meditech M250 computerised tomography (CT) machine was evaluated during the first half of 1984. Measurements were made of noise, modulation transfer function, slice width, radiation dose profile, uniformity and linearity of CT number, effective photon energy and parameters relating to machine specification, such as pixel size and scan time. All breakdowns were logged to indicate machine reliability. A comparison with the established EMI CT1010 and CT5005 was made for noise, resolution and multislice radiation dose, as well as the dose efficiency or quality (Q) factor for both head and body modes of operation. The M250 was found to perform to its intended specification with an acceptable level of reliability.

  16. 21 CFR 250.101 - Amphetamine and methamphetamine inhalers regarded as prescription drugs.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Amphetamine and methamphetamine inhalers regarded... DRUGS New Drug or Prescription Status of Specific Drugs § 250.101 Amphetamine and methamphetamine inhalers regarded as prescription drugs. (a) Recurring reports of abuse and misuse of methamphetamine (also...

  17. 30 CFR 250.806 - Safety and pollution prevention equipment quality assurance requirements.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Safety and pollution prevention equipment... Gas Production Safety Systems § 250.806 Safety and pollution prevention equipment quality assurance... install only certified safety and pollution prevention equipment (SPPE) in wells located on the OCS. SPPE...

  18. 41 CFR Appendix C to Part 60 - 250-Review of Personnel Processes

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true 250-Review of Personnel Processes C Appendix C to Part 60 Public Contracts and Property Management Other Provisions Relating to Public Contracts OFFICE OF FEDERAL CONTRACT COMPLIANCE PROGRAMS, EQUAL EMPLOYMENT OPPORTUNITY, DEPARTMENT...

  19. Production of $D^{\\pm}$ Mesons in $K^+$ Nucleon Collisions at 250 GeV

    Energy Technology Data Exchange (ETDEWEB)

    da Motta Filho, Helio [Rio de Janeiro, CBPF

    1993-11-01

    The $X_f$, $P^2_t$ and $p_t$ distribution of $D^{\\pm}$ mesons produced by 250 GeV $K^+$-nucleon interactions are measured through the decay channel $D^{\\pm} \\to K^{\\mp}\\pi^{\\pm} \\pi^{\\pm}$....

  20. MODIS/Aqua Calibrated Radiances 5-Min L1B Swath 250m - NRT

    Data.gov (United States)

    National Aeronautics and Space Administration — The 250 meter MODIS Level 1B Near Real Time (NRT) data set contains calibrated and geolocated at-aperture radiances for 2 discrete bands located in the 0.62 to 0.88...

  1. 250 kV 6 mA compact Cockcroft-Walton high-voltage power supply

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Zhan-Wen; Su, Xiao-Dong; Wei, Zhen; Huang, Zhi-Wu; Miao, Tian-You; Su, Tong-Ling [School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000 (China); Lu, Xiao-Long; Wang, Jun-Run; Yao, Ze-En, E-mail: zeyao@lzu.edu.cn [School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000 (China); Engineering Research Center for Neutron Application, Ministry of Education, Lanzhou University, Lanzhou 730000 (China)

    2016-08-15

    A compact power supply system for a compact neutron generator has been developed. A 4-stage symmetrical Cockcroft-Walton circuit is adopted to produce 250 kV direct current high-voltage. A 2-stage 280 kV isolation transformer system is used to drive the ion source power supply. For a compact structure, safety, and reliability during the operation, the Cockcroft-Walton circuit and the isolation transformer system are enclosed in an epoxy vessel containing the transformer oil whose size is about ∅350 mm × 766 mm. Test results indicate that the maximum output voltage of the power supply is 282 kV, and the stability of the output voltage is better than 0.63% when the high voltage power supply is operated at 250 kV, 6.9 mA with the input voltage varying ±10%.

  2. Clinical application study of bone marrow immunoscintigraphy using 99mTc-labelled anti-granulocyte monoclonal antibody BW250/183

    International Nuclear Information System (INIS)

    Liu Zengli; Wu Jinchang; Shi Yizhen; Tang Jun

    2001-01-01

    Objective: To study: (1) The labelling method of 99m Tc-BW250/183 and its organ distribution pattern after injection. (2) The clinical value of bone marrow immunoscintigraphy of evaluation of patients with aplastic anemia. (3) The clinical value of bone marrow immunoscintigraphy of determination of bone metastasis. Methods: (1) Whole body imaging was performed to one volunteer after injection of 555 MBq 99m Tc-BW250/183, meanwhile, 2 ml blood samples was taken from a cubital vein. The percentage of radioactivity of different organs and the kinetic data of in-vivo 99m Tc-BW250/183 was then calculated. In all the blood samples the peripheral leukocytes were counted by a standard procedure. (2) Bone marrow immunoscintigraphy were performed to 8 patients with aplastic anemia 4 h after injection of 99m Tc-BW250/183, 6 of them also underwent bone marrow imaging with 99m Tc-SC. (3) Bone marrow immunoscintigraphy and conventional bone scan were performed to 14 patients with suspected bone metastases to detect bone metastases. The results was compared with X-ray, X-CT or MRI. Results: 99m Tc-BW250/183 is a safe and ideal bone marrow imaging agent. Bone marrow immunoscintigraphy plays an important role in evaluating patients with aplastic anemia and determining bone metastases

  3. ERP C250 shows the elderly (cognitively normal, Alzheimer's disease) store more stimuli in short-term memory than Young Adults do.

    Science.gov (United States)

    Chapman, Robert M; Gardner, Margaret N; Mapstone, Mark; Klorman, Rafael; Porsteinsson, Anton P; Dupree, Haley M; Antonsdottir, Inga M; Kamalyan, Lily

    2016-06-01

    To determine how aging and dementia affect the brain's initial storing of task-relevant and irrelevant information in short-term memory. We used brain Event-Related Potentials (ERPs) to measure short-term memory storage (ERP component C250) in 36 Young Adults, 36 Normal Elderly, and 36 early-stage AD subjects. Participants performed the Number-Letter task, a cognitive paradigm requiring memory storage of a first relevant stimulus to compare it with a second stimulus. In Young Adults, C250 was more positive for the first task-relevant stimulus compared to all other stimuli. C250 in Normal Elderly and AD subjects was roughly the same to relevant and irrelevant stimuli in Intratrial Parts 1-3 but not 4. The AD group had lower C250 to relevant stimuli in part 1. Both normal aging and dementia cause less differentiation of relevant from irrelevant information in initial storage. There was a large aging effect involving differences in the pattern of C250 responses of the Young Adult versus the Normal Elderly/AD groups. Also, a potential dementia effect was obtained. C250 is a candidate tool for measuring short-term memory performance on a biological level, as well as a potential marker for memory changes due to normal aging and dementia. Copyright © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

  4. PENGARUH KELOMPOK REFERENSI TERHADAP KEPUTUSAN PEMBELIAN KAWASAKI NINJA 250 CC

    OpenAIRE

    Kartika WB, Sylvia; Sidig, Rosyid

    2018-01-01

    The purpose of this study is to examine the affect of reference groups  on purchasing decision of  Kawasaki Ninja 250 cc in the city of Jambi. Size of sample consist of 100 unit that chousen randomly. While data analysis used  multiple regression analysis. The results showed that simultaneouly   normative, value expression, and  informative have significant role. But, based on partiall test  normative has no significant affect. Hence,  reference group h...

  5. Study of solar features causing GMSs with 250γ H 400γ

    Indian Academy of Sciences (India)

    The effect of solar features on geospheric conditions leading to geomagnetic storms (GMSs) with planetary index, p ≥ 20 and the range of horizontal component of the Earth's magnetic field such that 250 < < 400 has been investigated using interplanetary magnetic field (IMF), solar wind plasma (SWP) and solar ...

  6. 30 CFR 250.290 - What operations require approval of the Conceptual Plan?

    Science.gov (United States)

    2010-07-01

    ... INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Plans and Information Deepwater Operations Plans (dwop) § 250.290 What operations require approval of the Conceptual Plan? You may... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What operations require approval of the...

  7. Gallup, NM AZ 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  8. Santa Fe, NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  9. Concentration of ions Co(II), Ni(II) at the Tokem-250 carboxylic cation exchange for catalysts development

    Science.gov (United States)

    Zharkova, Valentina; Bobkova, Ludmila; Brichkov, Anton; Kozik, Vladimir

    2017-11-01

    Sorption and catalytic properties of the cation exchanger are investigated. It was found that the Tokem-250 has a wide operating range of pH. The value of the effective ionization constant of the functional groups of the cation exchanger (pKa) is 6.59. The Tokem-250 cation exchanger exhibits selectivity to Ni2+ ions to Co2+ (D˜103). This is probably due to the stability of ion-exchange complexes detected by the method of diffuse reflectance electron spectroscopy (ESDD). According to these data, for Co2+ ions, in contrast to Ni2+, tetragonal distortion of octahedral coordination is characteristic, which has a positive effect on the stability of complexes with Co2+. To obtain spherical catalysts on the basis of Tokem-250, cobalt-containing samples of cation exchanger were used. The developed spherical materials have catalytic activity in the reactions of deep and partial oxidation of n-heptane.

  10. 12 CFR 250.408 - Short-term negotiable notes of banks not securities under section 32, Banking Act of 1933.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Short-term negotiable notes of banks not securities under section 32, Banking Act of 1933. 250.408 Section 250.408 Banks and Banking FEDERAL RESERVE... securities under section 32, Banking Act of 1933. (a) The Board of Governors has been asked whether short...

  11. 30 CFR 250.251 - If I propose activities in the Alaska OCS Region, what planning information must accompany the DPP?

    Science.gov (United States)

    2010-07-01

    ... Region, what planning information must accompany the DPP? 250.251 Section 250.251 Mineral Resources... Region, what planning information must accompany the DPP? If you propose development and production activities in the Alaska OCS Region, the following planning information must accompany your DPP: (a...

  12. 30 CFR 250.462 - What are the requirements for well-control drills?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the requirements for well-control... Other Drilling Requirements § 250.462 What are the requirements for well-control drills? You must conduct a weekly well-control drill with each drilling crew. Your drill must familiarize the crew with its...

  13. 30 CFR 250.1400 - How does MMS begin the civil penalty process?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How does MMS begin the civil penalty process...) Civil Penalties § 250.1400 How does MMS begin the civil penalty process? This subpart explains MMS's... other minerals operations in the OCS has a violation. Whenever MMS determines, on the basis of available...

  14. Covalently linked multimers of gold nanoclusters Au102(p-MBA)44 and Au∼250(p-MBA)n.

    Science.gov (United States)

    Lahtinen, Tanja; Hulkko, Eero; Sokołowska, Karolina; Tero, Tiia-Riikka; Saarnio, Ville; Lindgren, Johan; Pettersson, Mika; Häkkinen, Hannu; Lehtovaara, Lauri

    2016-11-10

    We present the synthesis, separation, and characterization of covalently-bound multimers of para-mercaptobenzoic acid (p-MBA) protected gold nanoclusters. The multimers were synthesized by performing a ligand-exchange reaction of a pre-characterized Au 102 (p-MBA) 44 nanocluster with biphenyl-4,4'-dithiol (BPDT). The reaction products were separated using gel electrophoresis yielding several distinct bands. The bands were analyzed by transmission electron microscopy (TEM) revealing monomer, dimer, and trimer fractions of the nanocluster. TEM analysis of dimers in combination with molecular dynamics simulations suggest that the nanoclusters are covalently bound via a disulfide bridge between BPDT molecules. The linking chemistry is not specific to Au 102 (p-MBA) 44 . The same approach yields multimers also for a larger monodisperse p-MBA-protected cluster of approximately 250 gold atoms, Au ∼250 (p-MBA) n . While the Au 102 (p-MBA) 44 is not plasmonic, the Au ∼250 (p-MBA) n nanocluster supports localized surface plasmon resonance (LSPR) at 530 nm. Multimers of the Au ∼250 (p-MBA) n exhibit additional transitions in their UV-vis spectrum at 630 nm and 810 nm, indicating the presence of hybridized LSPR modes. Well-defined structures and relatively small sizes make these systems excellent candidates for connecting ab initio theoretical studies and experimental quantum plasmonics. Moreover, our work opens new possibilities in the controlled synthesis of advanced monodisperse nanocluster superstructures.

  15. 30 CFR 250.220 - If I propose activities in the Alaska OCS Region, what planning information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... Region, what planning information must accompany the EP? 250.220 Section 250.220 Mineral Resources... activities in the Alaska OCS Region, what planning information must accompany the EP? If you propose exploration activities in the Alaska OCS Region, the following planning information must accompany your EP: (a...

  16. 30 CFR 250.404 - What are the requirements for the crown block?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the requirements for the crown block... General Requirements § 250.404 What are the requirements for the crown block? You must have a crown block safety device that prevents the traveling block from striking the crown block. You must check the device...

  17. Coomassie Brilliant Blue G-250 Dye: An Application for Forensic Fingerprint Analysis.

    Science.gov (United States)

    Brunelle, Erica; Le, Anh Minh; Huynh, Crystal; Wingfield, Kelly; Halámková, Lenka; Agudelo, Juliana; Halámek, Jan

    2017-04-04

    The Bradford reagent, comprised of the Coomassie Brilliant Blue G-250 dye, methanol, and phosphoric acid, has been traditionally used for quantifying proteins. Use of this reagent in the Bradford assay relies on the binding of the Coomassie Blue G-250 dye to proteins. However, the ability of the dye to react with a small group of amino acids (arginine, histidine, lysine, phenylalanine, tyrosine, and tryptophan) makes it a viable chemical assay for fingerprint analysis in order to identify the biological sex of the fingerprint originator. It is recognized that the identification of biological sex has been readily accomplished using two other methods; however, both of those systems are reliant upon a large group of amino acids, 23 to be precise. The Bradford assay, described here, was developed specifically to aid in the transition from targeting large groups of amino acids, as demonstrated in the previous studies, to targeting only a single amino acid without compromising the intensity of the response and/or the ability to differentiate between two attributes. In this work, we aim to differentiate between female fingerprints and male fingerprints.

  18. 30 CFR 250.1151 - How often must I conduct well production tests?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How often must I conduct well production tests... Requirements Well Tests and Surveys § 250.1151 How often must I conduct well production tests? (a) You must conduct well production tests as shown in the following table: You must conduct: And you must submit to...

  19. 30 CFR 250.110 - What must I include in my welding plan?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I include in my welding plan? 250.110... must I include in my welding plan? You must include all of the following in the Welding Plan that you... qualified personnel weld; (c) Practices and procedures for safe welding that address: (1) Welding in...

  20. Off-resonance transformer charging for 250-kV water Blumlein

    International Nuclear Information System (INIS)

    Cook, E.; Reginato, L.

    1978-01-01

    An off-resonance transformer for charging a 250-kV Blumlein system provides a viable alternative to other charging schemes by permitting the use of conventional thyratrons. Such a transformer must have reliability, a reasonable voltage step-up, and a non-reversing primary current. The analysis, design, and performance data for such a transformer are presented. The strong interrelationship between transformer design and Blumlein requirements necessitates that Blumlein description and design criterion be briefly presented prior to transformer design such that transformer load requirements be defined

  1. 30 CFR 250.802 - Design, installation, and operation of surface production-safety systems.

    Science.gov (United States)

    2010-07-01

    ... Analysis Checklists are included in API RP 14C you must utilize the analysis technique and documentation... device requirements for pipelines are under § 250.1004. (c) Specification for surface safety valves (SSV..., Recommended Practice for Installation, Maintenance, and Repair of Surface Safety Valves and Underwater Safety...

  2. 41 CFR 60-250.25 - Health insurance, life insurance and other benefit plans.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Health insurance, life... SEPARATED VETERANS, AND OTHER PROTECTED VETERANS Discrimination Prohibited § 60-250.25 Health insurance, life insurance and other benefit plans. (a) An insurer, hospital, or medical service company, health...

  3. Cooling system upgrading from 250 kW to 1 MW

    International Nuclear Information System (INIS)

    Anderson, T.V.; Johnson, A.G.; Ringle, J.C.

    1972-01-01

    The Oregon State TRIGA reactor (OSTR) power capability was upgraded from 250 KW to 1 MW in 1969; however, funds were not available for simultaneous upgrading of the cooling system. Since then, the OSTR has been selectively operating at full power with the original 250 KW cooling system. After funds were made available in 1971 the construction on the new heat exchanger building began. The new cooling system was installed, equipment was checked out, corrections were made, and acceptance tests were run. In addition, several days were required to clean up the primary system water, since increased water flow (350 gpm) swirled 4 year's collection of sediment off the reactor tank bottom and into the primary system. Three interesting items have been noticed, which are apparently a result of the cooling system upgrading: (1) the radiation levels above the reactor tank have been reduced by a factor of 2 to 3, (2) a low resonance vibration in the reactor core occurs at 1 MW. The vibration is attributed to a combination of increased water turbulence and subcooled (surface) nucleate boiling, and (3) direct radiation levels from the demineralizer tank have increased approximately 8-fold. This resulted in a relocation of the tank and the use of supplemental shielding. Increased operating time at higher average power levels, plus disturbance of; sediment on the bottom of the reactor tank are believed to be the main sources of the higher radiation levels

  4. Characterization of aging-induced microstructural changes in M250 maraging steel using magnetic parameters

    Energy Technology Data Exchange (ETDEWEB)

    Rajkumar, K.V. [Metallurgy and Materials Group, Indira Gandhi Centre for Atomic Research, Kalpakkam 603102 (India); Vaidyanathan, S. [Metallurgy and Materials Group, Indira Gandhi Centre for Atomic Research, Kalpakkam 603102 (India); Kumar, Anish [Metallurgy and Materials Group, Indira Gandhi Centre for Atomic Research, Kalpakkam 603102 (India); Jayakumar, T. [Metallurgy and Materials Group, Indira Gandhi Centre for Atomic Research, Kalpakkam 603102 (India)]. E-mail: tjk@igcar.gov.in; Raj, Baldev [Metallurgy and Materials Group, Indira Gandhi Centre for Atomic Research, Kalpakkam 603102 (India); Ray, K.K. [Indian Institute of Technology, Kharagpur 721302 (India)

    2007-05-15

    The best combinations of mechanical properties (yield stress and fracture toughness) of M250 maraging steel is obtained through short-term thermal aging (3-10 h) at 755 K. This is attributed to the microstructure containing precipitation of intermetallic phases in austenite-free low-carbon martensite matrix. Over-aged microstructure, containing reverted austenite degrades the mechanical properties drastically. Hence, it necessitates identification of a suitable non-destructive evaluation (NDE) technique for detecting any reverted austenite unambiguously during aging. The influence of aging on microstructure, room temperature hardness and non-destructive magnetic parameters such as coercivity (H {sub c}), saturation magnetization (M {sub s}) and magnetic Barkhausen emission (MBE) RMS peak voltage is studied in order to derive correlations between these parameters in aged M250 maraging steel. Hardness was found to increase with precipitation of intermetallics during initial aging and decrease at longer durations due to austenite reversion. Among the different magnetic parameters studied, MBE RMS peak voltage was found to be very sensitive to austenite reversion (non-magnetic phase) as they decreased drastically up on initiation of austenite reversion. Hence, this parameter can be effectively utilized to detect and quantify the reverted austenite in maraging steel specimen. The present study clearly indicates that the combination of MBE RMS peak voltage and hardness can be used for unambiguous characterization of microstructural features of technological and practical importance (3-10 h of aging duration at 755 K) in M250 grade maraging steel.

  5. Characterization of aging-induced microstructural changes in M250 maraging steel using magnetic parameters

    International Nuclear Information System (INIS)

    Rajkumar, K.V.; Vaidyanathan, S.; Kumar, Anish; Jayakumar, T.; Raj, Baldev; Ray, K.K.

    2007-01-01

    The best combinations of mechanical properties (yield stress and fracture toughness) of M250 maraging steel is obtained through short-term thermal aging (3-10 h) at 755 K. This is attributed to the microstructure containing precipitation of intermetallic phases in austenite-free low-carbon martensite matrix. Over-aged microstructure, containing reverted austenite degrades the mechanical properties drastically. Hence, it necessitates identification of a suitable non-destructive evaluation (NDE) technique for detecting any reverted austenite unambiguously during aging. The influence of aging on microstructure, room temperature hardness and non-destructive magnetic parameters such as coercivity (H c ), saturation magnetization (M s ) and magnetic Barkhausen emission (MBE) RMS peak voltage is studied in order to derive correlations between these parameters in aged M250 maraging steel. Hardness was found to increase with precipitation of intermetallics during initial aging and decrease at longer durations due to austenite reversion. Among the different magnetic parameters studied, MBE RMS peak voltage was found to be very sensitive to austenite reversion (non-magnetic phase) as they decreased drastically up on initiation of austenite reversion. Hence, this parameter can be effectively utilized to detect and quantify the reverted austenite in maraging steel specimen. The present study clearly indicates that the combination of MBE RMS peak voltage and hardness can be used for unambiguous characterization of microstructural features of technological and practical importance (3-10 h of aging duration at 755 K) in M250 grade maraging steel

  6. Characterization of aging-induced microstructural changes in M250 maraging steel using magnetic parameters

    Science.gov (United States)

    Rajkumar, K. V.; Vaidyanathan, S.; Kumar, Anish; Jayakumar, T.; Raj, Baldev; Ray, K. K.

    2007-05-01

    The best combinations of mechanical properties (yield stress and fracture toughness) of M250 maraging steel is obtained through short-term thermal aging (3-10 h) at 755 K. This is attributed to the microstructure containing precipitation of intermetallic phases in austenite-free low-carbon martensite matrix. Over-aged microstructure, containing reverted austenite degrades the mechanical properties drastically. Hence, it necessitates identification of a suitable non-destructive evaluation (NDE) technique for detecting any reverted austenite unambiguously during aging. The influence of aging on microstructure, room temperature hardness and non-destructive magnetic parameters such as coercivity ( Hc), saturation magnetization ( Ms) and magnetic Barkhausen emission (MBE) RMS peak voltage is studied in order to derive correlations between these parameters in aged M250 maraging steel. Hardness was found to increase with precipitation of intermetallics during initial aging and decrease at longer durations due to austenite reversion. Among the different magnetic parameters studied, MBE RMS peak voltage was found to be very sensitive to austenite reversion (non-magnetic phase) as they decreased drastically up on initiation of austenite reversion. Hence, this parameter can be effectively utilized to detect and quantify the reverted austenite in maraging steel specimen. The present study clearly indicates that the combination of MBE RMS peak voltage and hardness can be used for unambiguous characterization of microstructural features of technological and practical importance (3-10 h of aging duration at 755 K) in M250 grade maraging steel.

  7. MODIS/Terra Calibrated Radiances 5-Min L1B Swath 250m V005

    Data.gov (United States)

    National Aeronautics and Space Administration — The 250 meter MODIS Level 1B data set contains calibrated and geolocated at-aperture radiances for 2 discrete bands located in the 0.62 to 0.88 micron region of the...

  8. Study of the stability of the ground states and K-isomeric states of 250Fm and 254102 against spontaneous fission

    International Nuclear Information System (INIS)

    Lazarev, Yu.A.; Lobanov, Yu.V.; Sagajdak, R.N.; Utenkov, V.K.; Kharitonov, Yu.P.; Shirokovskij, I.V.; Tret'yakova, S.P.; Oganessyan, Yu.Ts.

    1988-01-01

    By employing the 249 Cf( 4 He, 3n) and 208 Pb( 48 Ca,2n) reactions, experiments to study the stability against spontaneous fission of the nuclides 250 Fm and 254 102 as well as of the two-quasi-particle (2 q-p) K isomers 250 Fm (T 1/2 =1,8±0,1 s) and 254 102 (T 1/2 =0,28±0,04 s) have been performed. The groundstate spontaneous fission of the two nuclides has been discovered and the corresponding branching ratios b sf and partial half-lives T sf , respectively, have been determined to be: (6,9±1,0)x10 -5 , 0,83±0,15 yr for 250 Fm; (1,7±0,5)x10 -3 , (3,2±0,9)x10 4 s for 254 102. As a by-product of these studies, new data about cross sections of the 206,208 Pb( 48 Ca,xn) reactions have been obtained. Experiments designed to search for the spontaneous fission of the 2 q-p K-isometric states in 250 Fm and 254 102 have not revealed the effect in question. The lower limits of the ratios of the partial spontaneous fission half-lives for the 2 q-p K-isomeric states to those for the respective ground states, T * sf /T sf , have been established to be≥10 -1 for 250m Fm/ 250 Fm and ≥5x10 -3 for 254m 102/ 254 102. This means that the stability of the 2 q-p K-isomeric states in 250 Fm and 254 102 against spontaneous fission is practically not inferior to that of the ground states of these nuclei. In accord with the experimental findings, the theoretical estimates of T * sf /T sf made in the present paper show that, due to the influence of the specialization and blocking effects on the potential energy and the effective mass associated with fission, spontaneous fission from 2 q-p K-isomeric states cannot be facilitated but, on the contrary, should be essentially hindered compared with ground-state spontaneous fission

  9. El Paso, TX NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  10. Las Cruces, NM TX 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  11. Saint Johns, AZ NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  12. Silver City, NM AZ 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  13. 27 CFR 24.250 - Application for use of new treating material or process.

    Science.gov (United States)

    2010-04-01

    ... of tests of the shelf life of the treated wine; (6) A tabulation of pertinent information derived... TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS WINE Storage, Treatment and Finishing of Wine § 24.250 Application for use of new treating material or process. (a) General. If the proprietor...

  14. 30 CFR 250.522 - When do I have to repeat casing diagnostic testing?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When do I have to repeat casing diagnostic... Operations Casing Pressure Management § 250.522 When do I have to repeat casing diagnostic testing? Casing diagnostic testing must be repeated according to the following table: When * * * you must repeat diagnostic...

  15. LCD OF AIR INTAKE MANIFOLDS PHASE 2: FORD F250 AIR INTAKE MANIFOLD

    Science.gov (United States)

    The life cycle design methodology was applied to the design analysis of three alternatives for the lower plehum of the air intake manifold for us with a 5.4L F-250 truck engine: a sand cast aluminum, a lost core molded nylon composite, and a vibration welded nylon composite. The ...

  16. 30 CFR 250.272 - If a State objects to the DPP's or DOCD's coastal zone consistency certification, what can I do?

    Science.gov (United States)

    2010-07-01

    ... coastal zone consistency certification, what can I do? 250.272 Section 250.272 Mineral Resources MINERALS... objects to the DPP's or DOCD's coastal zone consistency certification, what can I do? If an affected State objects to the coastal zone consistency certification accompanying your proposed or disapproved DPP or...

  17. High reflectance Cr/C multilayer at 250 eV for soft X-ray polarimetry

    Energy Technology Data Exchange (ETDEWEB)

    Wen, Mingwu; Jiang, Li; Zhang, Zhong; Huang, Qiushi [MOE Key Laboratory of Advanced Micro-Structured Materials, Institute of Precision Optical Engineering (IPOE), School of Physics Science and Engineering, Tongji University, Shanghai 200092 (China); Wang, Zhanshan, E-mail: wangzs@tongji.edu.cn [MOE Key Laboratory of Advanced Micro-Structured Materials, Institute of Precision Optical Engineering (IPOE), School of Physics Science and Engineering, Tongji University, Shanghai 200092 (China); She, Rui; Feng, Hua [Department of Engineering Physics, Tsinghua University, Beijing (China); Wang, Hongchang [Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE (United Kingdom)

    2015-10-01

    X-ray reflection near 45° via multilayer mirrors can be used for astronomical polarization measurements. A Cr/C multilayer mirror (designed for X-ray polarimetry at 250 eV), with a period thickness of 3.86 nm and a bi-layer number of 100, was fabricated using direct current magnetron sputtering. Grazing incidence X-ray reflectometry at 8 keV and transmission electron microscopy were used to investigate the multilayer structure. Different models were introduced to fit the hard X-ray reflectivity curve, which indicates that the layer thickness of two materials slightly drifts from the bottom to the top of the stack. Both the chromium and carbon layers are amorphous with asymmetric interfaces, while the Cr-on-C interface is slightly wider. Based on the good quality of the multilayer structure, a high reflectivity of 21.8% for the s-polarized light was obtained at 250 eV at a grazing incidence angle of 40.7°. The fabricated Cr/C multilayer mirror exhibits high reflectivity and polarization levels in the energy region of 240 eV–260 eV. - Highlights: • We fabricated Cr/C multilayer with 3.8 nm d-spacing. • X-ray reflectometry was used to determine the exact structure of Cr/C multilayer. • A high reflectivity of 21.8% for the s-polarized light was obtained at 250 eV. • Both Cr and C were found to be amorphous with slightly asymmetric interfaces. • A 4-layer model was used to fit and explain the results.

  18. 30 CFR 250.243 - What general information must accompany the DPP or DOCD?

    Science.gov (United States)

    2010-07-01

    ... characteristics of the produced oil (see definition under 30 CFR 254.6) that you will handle or store at the... definition under § 250.200) you will use to carry out your proposed development and production activities. In... that you expect will have the highest volume of liquid hydrocarbons. Include the estimated flow rate...

  19. 30 CFR 250.227 - What environmental impact analysis (EIA) information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What environmental impact analysis (EIA... and Information Contents of Exploration Plans (ep) § 250.227 What environmental impact analysis (EIA... requirements. Your EIA must: (1) Assess the potential environmental impacts of your proposed exploration...

  20. Design of diode electron gun for 250 kW CW klystron

    International Nuclear Information System (INIS)

    Prasad, M.; Pande, S.A.; Hannurkar, P.R.

    2005-01-01

    A 250 kW CW klystron at frequencies 350 MHz and 700 MHz is being developed at Centre for Advanced Technology. These klystrons are required for forthcoming project like 100 MeV proton Linac for Spallation Neutron Source (SNS) as a main rf sources. In order to develop klystrons, we have designed the diode electron gun, which delivers more than 10 A beam current at 50 kV. This paper describes the simulation results of electron gun with computer code EGUN. (author)

  1. New results on multi-muon production in 250 GeV μ+ Fe interactions

    International Nuclear Information System (INIS)

    Best, C.H.

    1981-05-01

    Preliminary results on the contribution to the nucleon structure function F 2 from charm particle production are presented. The data consist of dimuon and trimuon events from a high statistics experiment for a beam energy of 250 GeV. Exotic trimuon events have been observed and are compared to predictions from BETABETA and tautau production and decay. (author)

  2. 30 CFR 250.460 - What are the requirements for conducting a well test?

    Science.gov (United States)

    2010-07-01

    ... Other Drilling Requirements § 250.460 What are the requirements for conducting a well test? (a) If you intend to conduct a well test, you must include your projected plans for the test with your APD (form MMS...) You must give the District Manager at least 24-hours notice before starting a well test. [68 FR 8423...

  3. 77 FR 25720 - Determination That GRIFULVIN V (Griseofulvin Microcrystalline) Tablets, 250 Milligrams, Was Not...

    Science.gov (United States)

    2012-05-01

    ... been discontinued from marketing for reasons other than safety or effectiveness. ANDAs that refer to... Sale for Reasons of Safety or Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION: Notice... microcrystalline) tablets, 250 milligrams (mg), was not withdrawn from sale for reasons of safety or effectiveness...

  4. 30 CFR 250.136 - How will MMS determine if my operating performance is unacceptable?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How will MMS determine if my operating... Disqualification § 250.136 How will MMS determine if my operating performance is unacceptable? In determining if your operating performance is unacceptable, MMS will consider, individually or collectively: (a...

  5. Characteristic of metallic state preperties of mendelevium and other actinoids by thermochcomatography

    International Nuclear Information System (INIS)

    Hubener, S.; Zvara, I.

    1982-01-01

    The adsorption of the heavy actinoids Cf, Es, Fm, and Md on polycrystalline titanium and molybdenum has been studied by thermochromatography in comparison with several well-known metallic elements, in trace amounts. The data lead us to suggest that Es, Fm, and Md are divalent in the metallic state and, moreover, that the position of their f energy levels relativg to the Fermi-energy is lower than in the cases of Cf and Yb. A correlation was found between the experimental enthalpies of adsorption of the heavy actinoids and their predicted enthalpies of sublimation

  6. Analysis of the in vitro cleavage products of the tomato black ring virus RNA-1-encoded 250K polyprotein.

    OpenAIRE

    Demangeat, Gerard; Greif, Charles; Hemmer, O; Fritsch, C

    1990-01-01

    Tomato black ring virus RNA-1 was translated in a rabbit reticulocyte lysate. The primary translation product of Mr 250K, which corresponds to its whole coding capacity, was synthesized within 45 min and, during further incubation in the translation medium, was proteolytically processed. Essentially, four cleavage products (P190, P120, P60 and P50) were detected and located within P250 by pulse-chase and immunoprecipitation experiments. P190 is an intermediate cleavage product which is furthe...

  7. Shiprock, AZ NM CO UT 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  8. Remote (250 km Fiber Bragg Grating Multiplexing System

    Directory of Open Access Journals (Sweden)

    Manuel Lopez-Amo

    2011-09-01

    Full Text Available We propose and demonstrate two ultra-long range fiber Bragg grating (FBG sensor interrogation systems. In the first approach four FBGs are located 200 km from the monitoring station and a signal to noise ratio of 20 dB is obtained. The second improved version is able to detect the four multiplexed FBGs placed 250 km away, offering a signal to noise ratio of 6–8 dB. Consequently, this last system represents the longest range FBG sensor system reported so far that includes fiber sensor multiplexing capability. Both simple systems are based on a wavelength swept laser to scan the reflection spectra of the FBGs, and they are composed by two identical-lengths optical paths: the first one intended to launch the amplified laser signal by means of Raman amplification and the other one is employed to guide the reflection signal to the reception system.

  9. Flat-topped emission centred at 1 250 nm from quantum dot superluminescent diodes

    Directory of Open Access Journals (Sweden)

    R.A. Hogg

    2010-01-01

    Full Text Available We present a method for tailoring a broadband and flat-topped emission spectrum in quantum dot superluminescent diodes based upon modification of the dots-in-compositionally-modulated-well (DCMWELL technique. We demonstrate flat-topped emission with 95 nm full width at half maximum (FWHM, centred at 1 250 nm, and with output power in excess of 8 mW.

  10. Curiously modern DNA for a "250 million-year-old" bacterium.

    Science.gov (United States)

    Nickle, David C; Learn, Gerald H; Rain, Matthew W; Mullins, James I; Mittler, John E

    2002-01-01

    Studies of ancient DNA have attracted considerable attention in scientific journals and the popular press. Several of the more extreme claims for ancient DNA have been questioned on biochemical grounds (i.e., DNA surviving longer than expected) and evolutionary grounds (i.e., nucleotide substitution patterns not matching theoretical expectations for ancient DNA). A recent letter to Nature from Vreeland et al. (2000), however, tops all others with respect to age and condition of the specimen. These researchers extracted and cultured a bacterium from an inclusion body from what they claim is a 250 million-year (Myr)-old salt crystal. If substantiated, this observation could fundamentally alter views about bacterial physiology, ecology and evolution. Here we report on molecular evolutionary analyses of the 16S rDNA from this specimen. We find that 2-9-3 differs from a modern halophile, Salibacillus marismortui, by just 3 unambiguous bp in 16S rDNA, versus the approximately 59 bp that would be expected if these bacteria evolved at the same rate as other bacteria. We show, using a Poisson distribution, that unless it can be shown that S. marismortui evolves 5 to 10 times more slowly than other bacteria for which 16S rDNA substitution rates have been established, Vreeland et al.'s claim would be rejected at the 0.05 level. Also, a molecular clock test and a relative rates test fail to substantiate Vreeland et al.'s claim that strain 2-9-3 is a 250-Myr-old bacterium. The report of Vreeland et al. thus falls into a long series of suspect ancient DNA studies.

  11. 17 CFR 250.26 - Financial statement and recordkeeping requirements for registered holding companies and...

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Financial statement and..., PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 Forms, Procedure and Accounts § 250.26 Financial statement and... to form and content of financial statements; and (2) Shall make and keep current accounts, books and...

  12. Alveolar macrophage accumulation rates, for 28 nm and 250 nm PSL, are mediated by separate mechanisms

    Energy Technology Data Exchange (ETDEWEB)

    Moss, O R; Wong, V A, E-mail: moss@thehamner.or [Hamner Institutes for Health Sciences, Research Triangle Park, NC 27509-2137 (United States)

    2009-02-01

    When macrophages accumulate 28 nm and 250 nm diameter polystyrene latex (PSL) beads, the accumulation rates should reflect differences in molecular and cellular function. We used a confocal microscope to measure the accumulation rates of nanoparticles by F344-rat-alveolar macrophages (approx25,000 cells adhered to a 0.7 cm{sup 2} surface). Over the cells were layered 0.1 ml of media, and 0.1 ml of media-with-beads. Fresh cells were introduced for each exposure scenario. The maximum possible individual macrophage exposures were as follows: 8x10{sup 6}, 8x10{sup 5}, and 8x10{sup 4} 28 nm beads per macrophage; and 8x10{sup 4} and 1.12x10{sup 4} 250 nm beads per macrophage. Accumulation rates were estimated over 23 minutes. The increase in bead accumulation-rate matched changes in bead-availability: 7x increase for 250 nm beads; 100x increase for 28 nm beads; and 700x increase for all bead availabilities. The maximum sustained 28 nm bead accumulation rate was > 30,000 /min (for 5 min). Increases in bead accumulation could be explained by two mechanisms: bead-diffusion; and, for the macrophage, macropinocytosis. Also for the highest concentrations of 28 nm beads, we saw a colligative threshold - possibly due to beads masking the cell surface or obstructing cellular mechanisms.

  13. A kinetic-phase transformation near 250 K in potassium tetrachlorozincate

    International Nuclear Information System (INIS)

    Noiret, I.; Hedoux, A.; Guinet, Y.; Foulon, M.

    1993-01-01

    Raman-scattering experiments have been performed to study the successive phase transitions of K 2 ZnCl 4 over the temperature range (100/600) K. The spectra provide the temperature dependence of the mode frequencies and linewidths for two different spatial configurations: a(bb) c and c(aa) b. Special emphasis is put upon a new phenomenon observed in the spectra around 250 K in the c * /3 superstructure. Its kinetic character is revealed by complementary DSC measurements carried out over the range (120/300) K. This phenomenon is interpreted as a progressive structural transformation which corresponds to a slow modification of the tetrahedron distortions. (orig.)

  14. 12 CFR 250.220 - Whether member bank acting as trustee is prohibited by section 20 of the Banking Act of 1933 from...

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Whether member bank acting as trustee is prohibited by section 20 of the Banking Act of 1933 from acquiring majority of shares of mutual fund. 250.220 Section 250.220 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL...

  15. 30 CFR 250.133 - Will MMS reimburse me for my expenses related to inspections?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Will MMS reimburse me for my expenses related... Inspection of Operations § 250.133 Will MMS reimburse me for my expenses related to inspections? Upon request, MMS will reimburse you for food, quarters, and transportation that you provide for MMS representatives...

  16. Quest to validate and define performance for the high volume metallic stator PCP at 250 degrees Celsius

    Energy Technology Data Exchange (ETDEWEB)

    Noonan, S.G. [ConocoPhillips Co., Houston, TX (United States); Klaczek, W.; Piers, K. [C-FER Technologies, Edmonton, AB (Canada); Seince, L. [PCM USA Inc., Houston, TX (United States); Jahn, S. [Kudu Industries, Calgary, AB (Canada)

    2008-10-15

    ConocoPhillips has been searching for a high volume artificial lift system that will reliably operate in a 250 degree Celsius downhole environment to meet the needs of steam assisted gravity drainage (SAGD) operations. This paper described the complexity of building and operating a high temperature flow loop rated for 250 degrees Celsius. It also described the lessons learned while upgrading an existing flow loop, from the initial design, procurement and construction through to the final commissioning phases. The paper described the issues encountered with the first artificial lit system tested at 250 degrees Celsius. The system consisted of a metallic progressing cavity pump system rated for 6919 barrels per day at 500 rotations per minute. The final upgraded capabilities of the flow loop were also listed. Images of the upgraded flow loop were also provided. It was concluded that the test program not only served to validate and define the pump's performance, but also provided valuable lessons on the completion configuration and operational procedures. Testing new artificial lift technology in a controlled flow loop, rather than in field installation, provided the opportunity to test these pumping systems under a large variety of conditions to truly understand the performance and limitations of each pump. 3 refs., 1 tab., 5 figs.

  17. Ductility in hot isostatically pressed 250-grade maraging steel

    International Nuclear Information System (INIS)

    German, R.M.; Smugeresky, J.E.

    1978-01-01

    Prealloyed 250-grade maraging steel powder produced by the rotating electrode process was fully consolidated by hot isostatic pressing (HIP) at 1100 and 1200 0 C. The strength following aging (3 h at 480 0 C) equalled that of wrought material; however, ductility was negligible. This lack of ductility in the powder metallurgy product was traced to titanium segregation which occurred at the powder surface during power production. The formation of a titanium intermetallic at the prior particle boundaries during aging caused failure at low plastic strains. Altered aging treatments successfully broke up the embrittling film and resulted in a significant ductility recovery for the HIP material. Analysis of the fracture process indicates that further ductility gains are possible by reducing the titanium content, refining the particle size, and optimizing the thermal cycles

  18. 30 CFR 250.520 - When do I have to perform a casing diagnostic test?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When do I have to perform a casing diagnostic... Operations Casing Pressure Management § 250.520 When do I have to perform a casing diagnostic test? (a) You must perform a casing diagnostic test within 30 days after first observing or imposing casing pressure...

  19. 30 CFR 250.920 - What are the MMS requirements for assessment of fixed platforms?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the MMS requirements for assessment of... Structures Inspection, Maintenance, and Assessment of Platforms § 250.920 What are the MMS requirements for... in API RP 2A-WSD, Section 17.3. If MMS objects to the assessment category you used for your...

  20. HYSOGs250m, global gridded hydrologic soil groups for curve-number-based runoff modeling.

    Science.gov (United States)

    Ross, C Wade; Prihodko, Lara; Anchang, Julius; Kumar, Sanath; Ji, Wenjie; Hanan, Niall P

    2018-05-15

    Hydrologic soil groups (HSGs) are a fundamental component of the USDA curve-number (CN) method for estimation of rainfall runoff; yet these data are not readily available in a format or spatial-resolution suitable for regional- and global-scale modeling applications. We developed a globally consistent, gridded dataset defining HSGs from soil texture, bedrock depth, and groundwater. The resulting data product-HYSOGs250m-represents runoff potential at 250 m spatial resolution. Our analysis indicates that the global distribution of soil is dominated by moderately high runoff potential, followed by moderately low, high, and low runoff potential. Low runoff potential, sandy soils are found primarily in parts of the Sahara and Arabian Deserts. High runoff potential soils occur predominantly within tropical and sub-tropical regions. No clear pattern could be discerned for moderately low runoff potential soils, as they occur in arid and humid environments and at both high and low elevations. Potential applications of this data include CN-based runoff modeling, flood risk assessment, and as a covariate for biogeographical analysis of vegetation distributions.

  1. Comparative study of 250 mg/day terbinafine and 100 mg/day itraconazole for the treatment of cutaneous sporotrichosis.

    Science.gov (United States)

    Francesconi, Glaucia; Francesconi do Valle, Antonio Carlos; Passos, Sonia Lambert; de Lima Barros, Mônica Bastos; de Almeida Paes, Rodrigo; Curi, André Luiz Land; Liporage, José; Porto, Cássio Ferreira; Galhardo, Maria Clara Gutierrez

    2011-05-01

    Itraconazole is currently used for the treatment of cutaneous sporotrichosis. Terbinafine at a daily dose of 250 mg has been successfully applied to the treatment of cutaneous sporotrichosis. To compare the efficacy of 250 mg/day terbinafine and 100 mg/day itraconazole for the treatment of cutaneous sporotrichosis. A bidirectional cohort study was conducted on 55 patients receiving 250 mg/day terbinafine and 249 patients receiving 100 mg/day itraconazole. The latter patients were matched for age and clinical form to the terbinafine group at a ratio of 5:1. Sporothrix schenckii was isolated by culture from all patients (age range: 18-70 years), who were submitted to the standard care protocol consisting of clinical and laboratory evaluation and periodic visits. Cure was observed in 51 (92.7%) patients of the terbinafine group and 229 (92%) of the itraconazole group within a similar mean period of time (11.5 and 11.8 weeks, respectively). An increase in the terbinafine dose to 500 mg was necessary in two patients due to the lack of a response, and one patient presented recurrence. In the itraconazole group, two patients required a dose increase and three presented recurrence. Adverse events were equally frequent among patients receiving terbinafine (n = 4, 7.3%) and itraconazole (n = 19, 7.6%) and were generally mild without the need for drug discontinuation, except for two patients of the itraconazole group. Terbinafine administered at a daily dose of 250 mg is an effective and well-tolerated option for the treatment of cutaneous sporotrichosis.

  2. [Determination of 250 pesticide residues in vegetables using QuEChERS-ultra performance liquid chromatography-tandem mass spectrometry].

    Science.gov (United States)

    Zhang, Aizhi; Wang, Quanlin; Cao, Lili; Li, Yu; Shen, Hao; Shen, Jian; Zhang, Shufen; Man, Zhengyin

    2016-02-01

    A multiresidue analytical method for the determination of 250 pesticide residues in vegetables was developed by using QuEChERS-ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The target compounds were extracted with acetonitrile containing 1% (v/v) acetic acid, purified by a mixed sorbent of MgSO4, primary secondary amine (PSA), graphitized carbon black (GCB) and C18, separated on a Waters ACQUITY™ UPLC BEH C18 column (100 mm x 2. 1 mm, 1.7 µm) and detected by UPLC-MS/MS. Anhydrous magnesium sulfate was used as a dewatering agent. The effects of the amounts of MgSO4, PSA, GCB and C18 added on the recoveries of 250 pesticides were investigated. The results showed that the purification effect was best when 300 mg MgSO4, 200 mg PSA, 10 mg GCB and 100 mg C18 in 2 mL of the extract were added. For the 250 pesticide residues, the limits of detection (LODs) of the method were from 0. 01 to 50. 00 g/kg. The recoveries obtained ranged from 60. 1% to 120% at three spiked levels in Chinese chives with the relative standard deviations between 3. 5% and 19. 5% using matrix matched external standard method. The results showed that the method is able to meet requirements of the multiresidue detection of the 250 pesticides in vegetable. The method has the advantages of rapidity, simplicity, high sensitivity and better purification effect. It is suitable for the rapid determination of the common pesticides in vegetables, and it provides a strong guarantee for the risk assessments of the quality and safety of vegetables.

  3. Shared technologies in the development of the Titan 250 gas turbine system

    Energy Technology Data Exchange (ETDEWEB)

    Knodle, M.S.; Novaresi, M.A. [Solar Turbines Inc., San Diego, CA (United States). Titan Gas Turbine Systems Division

    2009-07-01

    Development of the Titan 250 industrial gas turbine system began in 2005 in response to demands from the petroleum industry and electricity producers for higher performance industrial gas turbine products in the 15-30 MW (25,000-45,000 hp) power range. The Titan 250 is Solar Turbine's most powerful package and its evolutionary hybrid-type design approach was based on shared aerodynamic, thermal, mechanical, and combustion technologies borrowed from the Taurus 65TM, Titan 130TM, and Mercury 50TM gas turbine systems. It produces 50 per cent more power than the Titan 130, while providing 40 per cent shaft efficiency with significantly fewer emissions. Thorough combustion system testing, use of proven materials, and hot section cooling provided a solid design basis. The engine is a two-shaft design that includes a 16-stage axial-flow compressor, a dry low emissions combustor for low NOx and CO output, a two-stage gas producer turbine operating at a turbine rotor inlet temperature of 1204 degrees C, and a three-stage, all-shrouded blade power turbine for maximum efficiency. The design also minimizes maintenance intervals to increase equipment availability. The gas turbine and gas compressor have been tested in component, subsystem, and full-scale development, and will be starting field operation in late 2009 to verify performance and mechanical integrity under all operating conditions. 3 refs., 1 tab., 26 figs.

  4. The clinical application study of bone marrow immunoscintigraphy using 99Tcm-BW250/183 in evaluating patients with aplastic anemia

    International Nuclear Information System (INIS)

    Liu Zengli; Wu Jinchang; Tang Jun; Wang Wei

    2002-01-01

    Objective: To study the clinical value of bone marrow immunoscintigraphy for evaluation of patients with aplastic anemia. Methods: Twelve patients with aplastic anemia underwent bone marrow immunoscintigraphy using 99 Tc m labelled anti-granulocyte monoclonal antibody BW250/183, 10 of them also underwent bone marrow imaging using 99 Tc m -sulfur colloid (SC) 2 - 3 days later. The semiquantitative indexes of bone marrow immunoscintigraphy of the patients were compared with those of control patients. Results: Bone marrow immunoscintigraphy was superior to 99 Tc m -SC bone marrow imaging. In patients with aplastic anemia, the accumulation of 99 Tc m -BW250/183 in bone marrow and spleen was lower and in liver and kidney was higher than those of control patients. Nine patients were found with multiple focal accumulation in bone marrow. Conclusion: Bone marrow immunoscintigraphy with 99 Tc m -BW250/183 plays an important role in evaluating patients with aplastic anemia

  5. Flexible low-voltage organic transistors with high thermal stability at 250 °C.

    Science.gov (United States)

    Yokota, Tomoyuki; Kuribara, Kazunori; Tokuhara, Takeyoshi; Zschieschang, Ute; Klauk, Hagen; Takimiya, Kazuo; Sadamitsu, Yuji; Hamada, Masahiro; Sekitani, Tsuyoshi; Someya, Takao

    2013-07-19

    Low-operating-voltage flexible organic thin-film transistors with high thermal stability using DPh-DNTT and SAM gate dielectrics are reported. The mobility of the transistors are decreased by 23% after heating to 250 °C for 30 min. Furthermore, flexible organic pseudo-CMOS inverter circuits, which are functional after heating to 200 °C, are demonstrated. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Homocysteine-lowering effect of 500 ug folic acid every other day versus 250 ug/day

    NARCIS (Netherlands)

    Brouwer, I.A.; Rooij, van I.A.L.M.; Dusseldorp, van M.; Thomas, C.M.G.; Blom, H.J.; Hautvast, J.G.A.J.; Eskes, T.K.A.B.

    2000-01-01

    Elevated plasma total homocysteine (tHcy) concentrations are a risk factor for neural tube defects and vascular diseases. Supplementation with folic acid decreases tHcy. We investigated whether supplementation with 500 ?g folic acid every other day is as effective in lowering tHcy as 250 ?g folic

  7. 30 CFR 250.214 - What geological and geophysical (G&G) information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What geological and geophysical (G&G... and Information Contents of Exploration Plans (ep) § 250.214 What geological and geophysical (G&G) information must accompany the EP? The following G&G information must accompany your EP: (a) Geological...

  8. Muusikamaailm. Maailmaesiettekanne Krimmis. Herderi preemiad 2002. Opera Metz 250. Günter Wand 90 / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2002-01-01

    Krimmis leiab aset Alemdar Karamanovi sümfoonia "Täideläinu" maailma esiettekanne. Johann Gottfried Herderi muusikapreemia sai nimekas rumeenia helilooja Aurel Stroe. Opera Metz Prantsusmaal tähistab oma 250ndat aastapäeva mitmete uuslavastustega. Dirigent Günter Wand tähistab 90ndat juubelit

  9. 30 CFR 250.1157 - How do I receive approval to produce gas-cap gas from an oil reservoir with an associated gas cap?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I receive approval to produce gas-cap gas from an oil reservoir with an associated gas cap? 250.1157 Section 250.1157 Mineral Resources... do I receive approval to produce gas-cap gas from an oil reservoir with an associated gas cap? (a...

  10. Low cycle fatigue behaviour of neutron irradiated copper alloys at 250 and 350 deg. C

    DEFF Research Database (Denmark)

    Singh, B.N.; Stubbins, J.F.; Toft, P.

    2000-01-01

    V) to influence levels of 1.0 - 1.5 x 1024 n/m2 (E> 1 MeV) at 250 and 350 deg. C. These irradiations were carried out in temperature controlled rigs where the irradiation temperature was monitored and controlledcontinuously throughout the whole irradiation experiment. Both unirradiated and irradiated speciments...

  11. Design of the proposed 250 MeV superconducting cyclotron magnet for proton therapy

    International Nuclear Information System (INIS)

    Dey, M.K.; Ahmed, M.; Murali, S.; Duttagupta, A.; Chaudhuri, J.; Mallik, C.; Bhandari, R.K.

    2006-01-01

    Here we describe the design calculations for the superconducting magnet of a 250 MeV proton cyclotron to be used for therapeutic purpose. Hard-edge approximation method has been adopted for finding the poletip geometry to meet the basic focusing requirements of the beam. Then the uniform-magnetization method has been applied to calculate the 3D magnetic field distribution due to saturated iron poletips, to verify the beam dynamical issues. (author)

  12. Polarized electrons from GaAs for parity nonconservation studies and Moeller scattering at 250 MeV

    International Nuclear Information System (INIS)

    Cates, G.D. Jr.

    1987-01-01

    A description is given of a polarized electron source based on photoemission from GaAs with circularly polarized light, which was developed for use in the study of parity nonconservation (PNC) in e- 12 C scattering at 250 MeV at the MIT Bates Linear Accelerator Center. A multi-chamber vacuum system houses up to four GaAs crystals simultaneously, and is contained in a Faraday cage to provide 365 KeV in electrostatic acceleration. Stable operation is achieved through the use of a modulated cw laser. The PNC experiment is discussed, particularly with regards to its requirements on the source. The peak current from the source is 20 mA, resulting in a current in excess of 6 mA at high energy. The electron beam polarization has been measured to be 0.36 ± 0.004 using Moeller scattering at 250 MeV

  13. NIR-Red Spectra-Based Disaggregation of SMAP Soil Moisture to 250 m Resolution Based on SMAPEx-4/5 in Southeastern Australia

    Directory of Open Access Journals (Sweden)

    Nengcheng Chen

    2017-01-01

    Full Text Available To meet the demand of regional hydrological and agricultural applications, a new method named near infrared-red (NIR-red spectra-based disaggregation (NRSD was proposed to perform a disaggregation of Soil Moisture Active Passive (SMAP products from 36 km to 250 m resolution. The NRSD combined proposed normalized soil moisture index (NSMI with SMAP data to obtain 250 m resolution soil moisture mapping. The experiment was conducted in southeastern Australia during SMAP Experiments (SMAPEx 4/5 and validated with the in situ SMAPEx network. Results showed that NRSD performed a decent downscaling (root-mean-square error (RMSE = 0.04 m3/m3 and 0.12 m3/m3 during SMAPEx-4 and SMAPEx-5, respectively. Based on the validation, it was found that the proposed NSMI was a new alternative indicator for denoting the heterogeneity of soil moisture at sub-kilometer scales. Attributed to the excellent performance of the NSMI, NRSD has a higher overall accuracy, finer spatial representation within SMAP pixels and wider applicable scope on usability tests for land cover, vegetation density and drought condition than the disaggregation based on physical and theoretical scale change (DISPATCH has at 250 m resolution. This revealed that the NRSD method is expected to provide soil moisture mapping at 250-resolution for large-scale hydrological and agricultural studies.

  14. Pharmacokinetics and tumor targeting of 131I-labeled F(ab')2 fragments of the chimeric monoclonal antibody G250: preclinical and clinical pilot studies.

    NARCIS (Netherlands)

    Brouwers, A.H.; Mulders, P.F.A.; Oosterwijk, E.; Buijs, W.C.A.M.; Corstens, F.H.M.; Boerman, O.C.; Oyen, W.J.G.

    2004-01-01

    INTRODUCTION: Clinical and animal studies of chimeric monoclonal antibody G250 (moAb cG250) for the targeting of clear-cell renal cell carcinoma (RCC), to date, have been with the intact IgG form. To determine whether F(ab')2 fragments are more suited for radioimmunotherapy (RIT) than intact IgG,

  15. Three-electrode pulse electron gun with currents up to 250 A

    International Nuclear Information System (INIS)

    Grigor'ev, Yu.V.; Shanturin, L.P.

    1977-01-01

    The design and operating conditions of a pulsed electron gun are described. The electron gun has three electrodes: a cathode, an anode and a control electrode in the form of a grid. The cathode is made from lanthanum hexaboride, which ensures its operation in a low vacuum at a temperature of 1,700 deg C. The control electrode and anode grid are fabricated from sheet tantalum. The anode-grid characteristics of the gun are given. It is shown that at an accelerating voltage of 100 kV, a temperature of 1,700 deg C and a zero control electrode potential the beam current is 250 A

  16. Investigations in a drift chamber using 250 MHz analogue-digital-converters

    International Nuclear Information System (INIS)

    Scharf, F.A.

    1993-06-01

    The performance of a new 250 MHz FADC module was investigated in a small drift chamber system. Straight tracks were induced in the chamber volume by UV-LASER beams. The time resolution was determined from drift time measurements for four neighbouring signal wires. By use of a beam splitter a pair of parallel beams was produced. An appropriate rotation of this pair relative to the signal wire plane allowed the determination of the double hit resolution. A comparison of the obtained values with the results achieved with 100 MHz FADC modules showed that the new module is well suited for chamber read out. The attainable improvements however are small. (orig.) [de

  17. Ultrasonic Characterization of Aging Behavior in M250 Grade Maraging Steel

    Science.gov (United States)

    Yeheskel, Ori

    2009-03-01

    The increase in sound velocities during the aging of M250 maraging steel reported by Rajkumar et al. was analyzed. The present article provides a new perspective on why and to what extent the sound velocities change during aging. The main parameter that affects the elastic moduli and the sound velocities in the early and intermediate stages of aging in maraging steel is the depletion of Ni from the martensitic matrix due to Ni3Ti and Ni3Mo formation. The issue of sound velocity increase with aging time was addressed here in a few different ways to support the validity of Ni depletion.

  18. Dense grid of narrow bandpass filters for the JST/T250 telescope: summary of results

    Science.gov (United States)

    Brauneck, Ulf; Sprengard, Ruediger; Bourquin, Sebastien; Marín-Franch, Antonio

    2018-01-01

    On the Javalambre mountain in Spain, the Centro de Estudios de Fisica del Cosmos de Aragon has setup two telescopes, the JST/T250 and the JAST/T80. The JAST/T80 telescope integrates T80Cam, a large format, single CCD camera while the JST/T250 will mount the JPCam instrument, a 1.2Gpix camera equipped with a 14-CCD mosaic using the new large format e2v 9.2k×9.2k 10-μm pixel detectors. Both T80Cam and JPCam integrate a large number of filters in dimensions of 106.8×106.8 mm2 and 101.7×95.5 mm2, respectively. For this instrument, SCHOTT manufactured 56 specially designed steep edged bandpass interference filters, which were recently completed. The filter set consists of bandpass filters in the range between 348.5 and 910 nm and a longpass filter at 915 nm. Most of the filters have full-width at half-maximum (FWHM) of 14.5 nm and a blocking between 250 and 1050 nm with optical density of OD5. Absorptive color glass substrates in combination with interference filters were used to minimize residual reflection in order to avoid ghost images. In spite of containing absorptive elements, the filters show the maximum possible transmission. This was achieved by using magnetron sputtering for the filter coating process. The most important requirement for the continuous photometric survey is the tight tolerancing of the central wavelengths and FWHM of the filters. This insures each bandpass has a defined overlap with its neighbors. A high image quality required a low transmitted wavefront error (<λ/4 locally and <λ/2 on the whole aperture), which was achieved even by combining two or three substrates. We report on the spectral and interferometric results measured on the whole set of filters.

  19. Estimating Coastal Turbidity using MODIS 250 m Band Observations

    Science.gov (United States)

    Davies, James E.; Moeller, Christopher C.; Gunshor, Mathew M.; Menzel, W. Paul; Walker, Nan D.

    2004-01-01

    Terra MODIS 250 m observations are being applied to a Suspended Sediment Concentration (SSC) algorithm that is under development for coastal case 2 waters where reflectance is dominated by sediment entrained in major fluvial outflows. An atmospheric correction based on MODIS observations in the 500 m resolution 1.6 and 2.1 micron bands is used to isolate the remote sensing reflectance in the MODIS 25Om resolution 650 and 865 nanometer bands. SSC estimates from remote sensing reflectance are based on accepted inherent optical properties of sediment types known to be prevalent in the U.S. Gulf of Mexico coastal zone. We present our findings for the Atchafalaya Bay region of the Louisiana Coast, in the form of processed imagery over the annual cycle. We also apply our algorithm to selected sites worldwide with a goal of extending the utility of our approach to the global direct broadcast community.

  20. 20 CFR 404.250 - Special computation rules for people who had a period of disability.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Special computation rules for people who had... Computation Rules for People Who Had A Period of Disability § 404.250 Special computation rules for people who had a period of disability. If you were disabled at some time in your life, received disability...

  1. 30 CFR 250.182 - When may the Secretary cancel a lease at the exploration stage?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When may the Secretary cancel a lease at the... Requirements, Lease Term Extensions, and Lease Cancellations § 250.182 When may the Secretary cancel a lease at... be modified to avoid the condition(s). The Secretary may cancel the lease if: (a) The primary lease...

  2. 76 FR 41045 - Special Conditions; Gulfstream Aerospace LP (GALP) Model G250 Airplane, Design Roll-Maneuver...

    Science.gov (United States)

    2011-07-13

    ... issue a finding of regulatory adequacy under Sec. 611 of Public Law 92-574, the ``Noise Control Act of... with electronic flight controls as they relate to design roll-maneuver requirements. The applicable... G250 airplane is equipped with an electronic flight control system that provides control through the...

  3. Dynamic aperture calculation for 100 GeV Au-Au and 250 GeV pp lattices with near third order resonance working point

    International Nuclear Information System (INIS)

    Gu, X.; Luo, Y.; Fischer, W.

    2010-01-01

    In the preparation for the 2011 RHIC 250 GeV polarized proton (pp) run, both experiment and simulation were carried out to investigate the possibility to accelerate the proton beam with a vertical tune near 2/3. It had been found experimentally in Run-9 that accelerating the proton beam with a vertical tune close to 2/3 will greatly benefit the transmission of the proton polarization. In this note, we report the calculated dynamic apertures with the 100 GeV Au run and 250 GeV proton run lattices with vertical tunes close to the third order resonance. We will compare the third order resonance band width between the beam experiment and the simulation with the 100 GeV Au lattices. And we also will compare the calculated resonance band width between the 100 GeV Au and 250 GeV proton run lattices.

  4. Radiation vulcanization of natural rubber latex using 250 keV electron beam machine

    Energy Technology Data Exchange (ETDEWEB)

    Chirinos, H.; Yoshii, F.; Makuuchi, K.; Lugao, A. E-mail: ablugao@net.ipen.br

    2003-08-01

    The sensitized radiation vulcanization of natural rubber latex has been carried out with 250 keV electrons. Latex was irradiated over a range of the beam current from 5 to 20 mA in the presence of sensitizers like the n-butyl acrylate (n-BA). The vulcanization dose decreases with increasing beam current condition. The rate of vulcanization (R{sub vul}) depends on the beam current (I) as given by the equation R{sub vul}=kI{sup 0.6}.

  5. Analysis of the in vitro cleavage products of the tomato black ring virus RNA-1-encoded 250K polyprotein.

    Science.gov (United States)

    Demangeat, G; Greif, C; Hemmer, O; Fritsch, C

    1990-08-01

    Tomato black ring virus RNA-1 was translated in a rabbit reticulocyte lysate. The primary translation product of Mr 250K, which corresponds to its whole coding capacity, was synthesized within 45 min and, during further incubation in the translation medium, was proteolytically processed. Essentially, four cleavage products (P190, P120, P60 and P50) were detected and located within P250 by pulse-chase and immunoprecipitation experiments. P190 is an intermediate cleavage product which is further cleaved to form P60 and P120. P120, which contains the region that has been assigned to the virus protease and the virus polymerase, was not further cleaved in vitro.

  6. Performances of 250 Amp-hr lithium/thionyl chloride cells

    Science.gov (United States)

    Goualard, Jacques

    1991-01-01

    A 250 Ah lithium thionyl chloride battery is being developed for a booster rocket engine. Extensive cell testing is running to evaluate functional and safety performances. Some results are presented. The lithium/thionyl chloride batteries were selected for their high energy density (low weight) as compared to other sources. The temperature of a lower weight item will be more sensitive to variations of internal and external heat fluxes than a heavier one. The use of high energy density L/TC batteries is subjected to stringent thermal environments to have benefit of energy density and to stay safe in any conditions. The battery thermal environment and discharge rate have to be adjusted to obtain the right temperature range at cell level, to have the maximum performances. Voltage and capacity are very sensitive to temperature. This temperature is the cell internal actual temperature during discharge. This temperature is directed by external thermal environment and by cell internal heat dissipation, i.e., cell actual voltage.

  7. Performances of 250 Amp-hr lithium/thionyl chloride cells

    Science.gov (United States)

    Goualard, Jacques

    1991-05-01

    A 250 Ah lithium thionyl chloride battery is being developed for a booster rocket engine. Extensive cell testing is running to evaluate functional and safety performances. Some results are presented. The lithium/thionyl chloride batteries were selected for their high energy density (low weight) as compared to other sources. The temperature of a lower weight item will be more sensitive to variations of internal and external heat fluxes than a heavier one. The use of high energy density L/TC batteries is subjected to stringent thermal environments to have benefit of energy density and to stay safe in any conditions. The battery thermal environment and discharge rate have to be adjusted to obtain the right temperature range at cell level, to have the maximum performances. Voltage and capacity are very sensitive to temperature. This temperature is the cell internal actual temperature during discharge. This temperature is directed by external thermal environment and by cell internal heat dissipation, i.e., cell actual voltage.

  8. Properties of PZT-Based Piezoelectric Ceramics Between -150 and 250 C

    Science.gov (United States)

    Hooker, Matthew W.

    1998-01-01

    The properties of three PZT-based piezoelectric ceramics and one PLZT electrostrictive ceramic were measured as a function of temperature. In this work, the dielectric, ferroelectric polarization versus electric field, and piezoelectric properties of PZT-4, PZT-5A, PZT-5H, and PLZT-9/65/35 were measured over a temperature range of -150 to 250 C. In addition to these measurements, the relative thermal expansion of each composition was measured from 25 to 600 C and the modulus of rupture of each material was measured at room temperature. This report describes the experimental results and compares and contrasts the properties of these materials with respect to their applicability to intelligent aerospace systems.

  9. 30 CFR 250.108 - What requirements must I follow for cranes and other material-handling equipment?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What requirements must I follow for cranes and... Performance Standards § 250.108 What requirements must I follow for cranes and other material-handling equipment? (a) All cranes installed on fixed platforms must be operated in accordance with American...

  10. Analysis of MODIS 250 m Time Series Product for LULC Classification and Retrieval of Crop Biophysical Parameter

    Science.gov (United States)

    Verma, A. K.; Garg, P. K.; Prasad, K. S. H.; Dadhwal, V. K.

    2016-12-01

    Agriculture is a backbone of Indian economy, providing livelihood to about 70% of the population. The primary objective of this research is to investigate the general applicability of time-series MODIS 250m Normalized difference vegetation index (NDVI) and Enhanced vegetation index (EVI) data for various Land use/Land cover (LULC) classification. The other objective is the retrieval of crop biophysical parameter using MODIS 250m resolution data. The Uttar Pradesh state of India is selected for this research work. A field study of 38 farms was conducted during entire crop season of the year 2015 to evaluate the applicability of MODIS 8-day, 250m resolution composite images for assessment of crop condition. The spectroradiometer is used for ground reflectance and the AccuPAR LP-80 Ceptometer is used to measure the agricultural crops Leaf Area Index (LAI). The AccuPAR measures Photosynthetically Active Radiation (PAR) and can invert these readings to give LAI for plant canopy. Ground-based canopy reflectance and LAI were used to calibrate a radiative transfer model to create look-up table (LUT) that was used to simulate LAI. The seasonal trend of MODIS-derived LAI was used to find crop parameter by adjusting the LAI simulated from climate-based crop yield model. Cloud free MODIS images of 250m resolution (16 day composite period) were downloaded using LP-DAAC website over a period of 12 months (Jan to Dec 2015). MODIS both the VI products were found to have sufficient spectral, spatial and temporal resolution to detect unique signatures for each class (water, fallow land, urban, dense vegetation, orchard, sugarcane and other crops). Ground truth data were collected using JUNO GPS. Multi-temporal VI signatures for vegetation classes were consistent with its general phenological characteristic and were spectrally separable at some point during the growing season. The MODIS NDVI and EVI multi-temporal images tracked similar seasonal responses for all croplands and were

  11. Transfer free graphene growth on SiO2 substrate at 250 °C

    Science.gov (United States)

    Vishwakarma, Riteshkumar; Rosmi, Mohamad Saufi; Takahashi, Kazunari; Wakamatsu, Yuji; Yaakob, Yazid; Araby, Mona Ibrahim; Kalita, Golap; Kitazawa, Masashi; Tanemura, Masaki

    2017-03-01

    Low-temperature growth, as well as the transfer free growth on substrates, is the major concern of graphene research for its practical applications. Here we propose a simple method to achieve the transfer free graphene growth on SiO2 covered Si (SiO2/Si) substrate at 250 °C based on a solid-liquid-solid reaction. The key to this approach is the catalyst metal, which is not popular for graphene growth by chemical vapor deposition. A catalyst metal film of 500 nm thick was deposited onto an amorphous C (50 nm thick) coated SiO2/Si substrate. The sample was then annealed at 250 °C under vacuum condition. Raman spectra measured after the removal of the catalyst by chemical etching showed intense G and 2D peaks together with a small D and intense SiO2 related peaks, confirming the transfer free growth of multilayer graphene on SiO2/Si. The domain size of the graphene confirmed by optical microscope and atomic force microscope was about 5 μm in an average. Thus, this approach will open up a new route for transfer free graphene growth at low temperatures.

  12. Radiation damage studies on STAR250 CMOS sensor at 300 keV for electron microscopy

    International Nuclear Information System (INIS)

    Faruqi, A.R.; Henderson, R.; Holmes, J.

    2006-01-01

    There is a pressing need for better electronic detectors to replace film for recording high-resolution images using electron cryomicroscopy. Our previous work has shown that direct electron detection in CMOS sensors is promising in terms of resolution and efficiency at 120 keV [A.R. Faruqi, R. Henderson, M. Prydderch, R. Turchetta, P. Allport, A. Evans, Nucl. Instr. and Meth. 546 (2005) 170], but in addition, the detectors must not be damaged by the electron irradiation. We now present new measurements on the radiation tolerance of a 25 μm pitch CMOS active-pixel sensor, the STAR250, which was designed by FillFactory using radiation-hard technology for space applications. Our tests on the STAR250 aimed to establish the imaging performance at 300 keV following irradiation. The residual contrast, measured on shadow images of a 300 mesh grid, was >80% after corrections for increased dark current, following irradiation with up to 5x10 7 electrons/pixel (equivalent to 80,000 electron/μm 2 ). A CMOS sensor with this degree of radiation tolerance would survive a year of normal usage for low-dose electron cryomicroscopy, which is a very useful advance

  13. 47 CFR 25.250 - Sharing between NGSO MSS Feeder links Earth Stations in the 19.3-19.7 GHz and 29.1-29.5 GHz Bands.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Sharing between NGSO MSS Feeder links Earth Stations in the 19.3-19.7 GHz and 29.1-29.5 GHz Bands. 25.250 Section 25.250 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Technical Standards § 25...

  14. 30 CFR 250.524 - When am I required to take action from my casing diagnostic test?

    Science.gov (United States)

    2010-07-01

    ... pressure (MAWOP); (b) Any fixed platform well with a casing pressure that is greater than 100 psig and that... bled down to prevent it from exceeding its MAWOP, except during initial startup operations described in § 250.521; (e) Any hybrid well with casing or riser pressure exceeding 100 psig; or (f) Any subsea well...

  15. Two different mechanisms associated with ripple-like oscillations (100-250 Hz) in the human epileptic subiculum in vitro

    Science.gov (United States)

    Alvarado-Rojas, C; Huberfeld, G; Baulac, M; Clemenceau, S; Charpier, S; Miles, R; Menendez de la Prida, L; Le Van Quyen, M

    2015-01-01

    Transient high-frequency oscillations (150-600 Hz) in local field potential generated by human hippocampal and parahippocampal areas have been related to both physiological and pathological processes. The cellular basis and effects of normal and abnormal forms of high-frequency oscillations (HFO) has been controversial. Here, we searched for HFOs in slices of the subiculum prepared from human hippocampal tissue resected for treatment of pharmacoresistant epilepsy. HFOs occurred spontaneously in extracellular field potentials during interictal discharges (IID) and also during pharmacologically induced preictal discharges (PID) preceding ictal-like events. While most of these events might be considered pathological since they invaded the fast ripple band (>250 Hz), others were spectrally similar to physiological ripples (150-250 Hz). Do similar cellular mechanisms underly IID-ripples and PID-ripples? Are ripple-like oscillations a valid proxy of epileptogenesis in human TLE? With combined intra- or juxta-cellular and extracellular recordings, we showed that, despite overlapping spectral components, ripple-like IID and PID oscillations were associated with different cellular and synaptic mechanisms. IID-ripples were associated with rhythmic GABAergic and glutamatergic synaptic potentials with moderate neuronal firing. In contrast, PID-ripples were associated with depolarizing synaptic inputs frequently reaching the threshold for bursting in most cells. Thus ripple-like oscillations (100-250 Hz) in the human epileptic hippocampus are associated with different mechanisms for synchrony reflecting distinct dynamic changes in inhibition and excitation during interictal and pre-ictal states. PMID:25448920

  16. MODIS/Terra Land Water Mask Derived from MODIS and SRTM L3 Global 250m SIN Grid V005

    Data.gov (United States)

    National Aeronautics and Space Administration — The MODIS 250 m land-water mask (Short Name: MOD44W) is an improvement over the existing MODIS Nadir Bidirectional Reflectance Distribution Function (BRDF)-Adjusted...

  17. A 250-Mbit/s ring local computer network using 1.3-microns single-mode optical fibers

    Science.gov (United States)

    Eng, S. T.; Tell, R.; Andersson, T.; Eng, B.

    1985-01-01

    A 250-Mbit/s three-station fiber-optic ring local computer network was built and successfully demonstrated. A conventional token protocol was employed for bus arbitration to maximize the bus efficiency under high loading conditions, and a non-return-to-zero (NRS) data encoding format was selected for simplicity and maximum utilization of the ECL-circuit bandwidth.

  18. Test results from the LLNL 250 GHz CARM experiment

    International Nuclear Information System (INIS)

    Kulke, B.; Caplan, M.; Bubp, D.; Houck, T.; Rogers, D.; Trimble, D.; VanMaren, R.; Westenskow, G.; McDermott, D.B.; Luhmann, N.C. Jr.; Danly, B.

    1991-05-01

    We have completed the initial phase of a 250 GHz CARM experiment, driven by the 2 MeV, 1 kA, 30 ns induction linac at the LLNL ARC facility. A non-Brillouin, solid, electron beam is generated from a flux-threaded, thermionic cathode. As the beam traverses a 10 kG plateau produced by a superconducting magnet, ten percent of the beam energy is converted into rotational energy in a bifilar helix wiggler that produces a spiraling, 50 G, transverse magnetic field. The beam is then compressed to a 5 mm diameter as it drifts into a 30 kG plateau. For the present experiment, the CARM interaction region consisted of a single Bragg section resonator, followed by a smooth-bore amplifier section. Using high-pass filters, we have observed broadband output signals estimated to be at the several megawatt level in the range 140 to over 230 GHz. This is consistent with operation as a superradiant amplifier. Simultaneously, we also observed K a band power levels near 3 MW

  19. Test results from the LLNL 250 GHz CARM experiment

    International Nuclear Information System (INIS)

    Kulke, B.; Caplan, M.; Bubp, D.; Houck, T.; Rogers, D.; Trimble, D.; VanMaren, R.; Westenskow, G.; McDermott, D.B.; Luhmann, N.C. Jr.; Danly, B.

    1991-01-01

    The authors have completed the initial phase of a 250 GHz CARM experiment, driven by the 2 MeV, 1 kA, 30 ns induction linac at the LLNL ARC facility. A non-Brillouin, solid, electron beam is generated from a flux-threaded, thermionic cathode. As the beam traverses a 10 kG plateau produced by a superconducting magnet, ten percent of the beam energy is converted into rotational energy in a bifilar helix wiggler that produces a spiraling, 50 G, transverse magnetic field. The beam is then compressed to a 5 mm diameter as it drifts into a 30 kG plateau. For the present experiment, the CARM interaction region consisted of a single Bragg section resonator, followed by a smooth-bore amplifier section. Using high-pass filters, they have observed broadband output signals estimated to be at the several megawatt level in the range 140 to over 230 GHz. This is consistent with operation as a superradiant amplifier. Simultaneously, they also observed K a band power levels near 3 MW

  20. Predicted Performance of a Dc Beam Driven Fem Oscillator Designed for Fusion Applications at 200-250 Ghz

    NARCIS (Netherlands)

    Caplan, M.; Best, R. W. B.; Verhoeven, A. G. A.; van der Wiel, M. J.; Urbanus, W. H.; Bratman, V. L.; Denisov, G. G.

    1993-01-01

    At the FOM Institute (The Netherlands) a free electron laser using a dc beam with depressed collector is being developed for plasma heating, which will be capable of producing 1 MW cw output over an adjustable tuning range of 200-250 GHz. The basic design parameters for the electron beam, undulator

  1. 30 CFR 250.244 - What geological and geophysical (G&G) information must accompany the DPP or DOCD?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What geological and geophysical (G&G... Operations Coordination Documents (docd) § 250.244 What geological and geophysical (G&G) information must accompany the DPP or DOCD? The following G&G information must accompany your DPP or DOCD: (a) Geological...

  2. Snow Cover Maps from MODIS Images at 250 m Resolution, Part 2: Validation

    Directory of Open Access Journals (Sweden)

    Marc Zebisch

    2013-03-01

    Full Text Available The performance of a new algorithm for binary snow cover monitoring based on Moderate Resolution Imaging Spectroradiometer (MODIS satellite images at 250 m resolution is validated using snow cover maps (SCA based on Landsat 7 ETM+ images and in situ snow depth measurements from ground stations in selected test sites in Central Europe. The advantages of the proposed algorithm are the improved ground resolution of 250 m and the near real-time availability with respect to the 500 m standard National Aeronautics and Space Administration (NASA MODIS snow products (MOD10 and MYD10. It allows a more accurate snow cover monitoring at a local scale, especially in mountainous areas characterized by large landscape heterogeneity. The near real-time delivery makes the product valuable as input for hydrological models, e.g., for flood forecast. A comparison to sixteen snow cover maps derived from Landsat ETM/ETM+ showed an overall accuracy of 88.1%, which increases to 93.6% in areas outside of forests. A comparison of the SCA derived from the proposed algorithm with standard MODIS products, MYD10 and MOD10, indicates an agreement of around 85.4% with major discrepancies in forested areas. The validation of MODIS snow cover maps with 148 in situ snow depth measurements shows an accuracy ranging from 94% to around 82%, where the lowest accuracies is found in very rugged terrain restricted to in situ stations along north facing slopes, which lie in shadow in winter during the early morning acquisition.

  3. Structure function scaling in a Reλ = 250 turbulent mixing layer

    KAUST Repository

    Attili, Antonio

    2011-12-22

    A highly resolved Direct Numerical Simulation of a spatially developing turbulent mixing layer is presented. In the fully developed region, the flow achieves a turbulent Reynolds number Reλ = 250, high enough for a clear separation between large and dissipative scales, so for the presence of an inertial range. Structure functions have been calculated in the self-similar region using velocity time series and Taylor\\'s frozen turbulence hypothesis. The Extended Self-Similarity (ESS) concept has been employed to evaluate relative scaling exponents. A wide range of scales with scaling exponents and intermittency levels equal to homogeneous isotropic turbulence has been identified. Moreover an additional scaling range exists for larger scales; it is characterized by smaller exponents, similar to the values reported in the literature for flows with strong shear.

  4. Structure function scaling in a Reλ = 250 turbulent mixing layer

    KAUST Repository

    Attili, Antonio; Bisetti, Fabrizio

    2011-01-01

    A highly resolved Direct Numerical Simulation of a spatially developing turbulent mixing layer is presented. In the fully developed region, the flow achieves a turbulent Reynolds number Reλ = 250, high enough for a clear separation between large and dissipative scales, so for the presence of an inertial range. Structure functions have been calculated in the self-similar region using velocity time series and Taylor's frozen turbulence hypothesis. The Extended Self-Similarity (ESS) concept has been employed to evaluate relative scaling exponents. A wide range of scales with scaling exponents and intermittency levels equal to homogeneous isotropic turbulence has been identified. Moreover an additional scaling range exists for larger scales; it is characterized by smaller exponents, similar to the values reported in the literature for flows with strong shear.

  5. Relationship between thermal embrittlement and hydrogen cracking in 18Ni(250) maraging steel

    International Nuclear Information System (INIS)

    Rack, H.J.

    1974-01-01

    The role of grain boundary precipitate structure on the stress corrosion susceptibility of 18Ni(250) maraging steel was examined. Varying solution treatment procedures were used to achieve either a precipitate-free grain boundary or one containing a high density of Ti(C,N) particles. The introduction of these treatments, although drastically affecting the monotonic fracture toughness, did not significantly alter the stress corrosion threshold in 100 percent relative humidity. These results are shown to be consistent with the previous suggestion that, under open circuit conditions, hydrogen-assisted cracking controls the environmental crack growth behavior of 18Ni maraging steels. (U.S.)

  6. Hypothetical accident scenario analyses for a 250-MW(t) modular high temperature gas-cooled reactor

    International Nuclear Information System (INIS)

    Harrington, R.M.; Ball, S.J.; Cleveland, J.C.

    1985-11-01

    This paper describes calculations performed to characterize the inherent safety of a 250-MW(t), 100-MW(e), pebble bed modular high temperature gas-cooled reactor (HTGR) design with vertical in-line arrangement (i.e., upflow core with steam generators directly above the core). A variety of postulated accident sequences involving combinations of loss of forced primary coolant (helium) circulation, loss of primary coolant pressurization, and loss of heat sink were studied and were discussed

  7. Motor power calculation for driving conveyor chain in gamma irradiator BATAN 2x250 k curie

    International Nuclear Information System (INIS)

    Ari Satmoko; Syamsurrijal Ramdja; Sutomo Budihardjo

    2010-01-01

    Recently, an Irradiator BATAN 2X250 k Curie for agricultural product is under design. The installation is provided by the gamma source about 2x250 k Curie. Agricultural products are carried into carriers and these carriers are hanged on the conveyor chain. The chain moves into a radiation chamber following the trajectoire. The chain is drived by motor. For this reason, the calculation is performed to determine the motor power. After resolving the force equilibrium equation, the force and power of the motor needed to drive the chain are obtained. Numerical method by using V Basic language is used to resolve the equation. The calculation result shows the correlation between friction coefficient and motor power. From the evaluation, it is decided that the friction coefficient should be less than 0,015. By this friction, the motor power is about 3. 13 k Watt. From the evaluation, it is also obtained that the radius of the curve trajectory shall not be too small. Combination between high friction and small curve radius could lead to the locked condition in which high power motor are not be able to move the conveyor chain). (author)

  8. Bionics by examples 250 scenarios from classical to modern times

    CERN Document Server

    Nachtigall, Werner

    2015-01-01

    Bionics means learning from the nature for the development of technology. The science of "bionics" itself is classified into several sections, from materials and structures over procedures and processes until evolution and optimization. Not all these areas, or only a few, are really known in the public and also in scientific literature. This includes the Lotus-effect, converted to the contamination-reduction of fassades and the shark-shed-effect, converted to the  resistance-reduction of airplanes. However, there are hundreds of highly interesting examples that contain the transformation of principles of the nature into technology. From the large number of these examples, 250 were selected for the present book according to "prehistory", "early-history", "classic" and "modern time". Most examples are new. Every example includes a printed page in a homogeneous arrangement. The examples from the field "modern time" are joint in blocks corresponding to the sub-disciplines of bionics.

  9. 17 CFR 250.53 - Certain registered holding company financings in connection with the acquisition of one or more...

    Science.gov (United States)

    2010-04-01

    ... Financial Transactions 2 § 250.53 Certain registered holding company financings in connection with the acquisition of one or more exempt wholesale generators. (a) In determining whether to approve the issue or... shall be kept in conformity with United States generally accepted accounting principles (“GAAP”). (B...

  10. Radionuclide and Fluorescence Imaging of Clear Cell Renal Cell Carcinoma Using Dual Labeled Anti-Carbonic Anhydrase IX Antibody G250.

    Science.gov (United States)

    Muselaers, Constantijn H J; Rijpkema, Mark; Bos, Desirée L; Langenhuijsen, Johan F; Oyen, Wim J G; Mulders, Peter F A; Oosterwijk, Egbert; Boerman, Otto C

    2015-08-01

    Tumor targeted optical imaging using antibodies labeled with near infrared fluorophores is a sensitive imaging modality that might be used during surgery to assure complete removal of malignant tissue. We evaluated the feasibility of dual modality imaging and image guided surgery with the dual labeled anti-carbonic anhydrase IX antibody preparation (111)In-DTPA-G250-IRDye800CW in mice with intraperitoneal clear cell renal cell carcinoma. BALB/c nu/nu mice with intraperitoneal SK-RC-52 lesions received 10 μg DTPA-G250-IRDye800CW labeled with 15 MBq (111)In or 10 μg of the dual labeled irrelevant control antibody NUH-82 (20 mice each). To evaluate when tumors could be detected, 4 mice per group were imaged weekly during 5 weeks with single photon emission computerized tomography/computerized tomography and the fluorescence imaging followed by ex vivo biodistribution studies. As early as 1 week after tumor cell inoculation single photon emission computerized tomography and fluorescence images showed clear delineation of intraperitoneal clear cell renal cell carcinoma with good concordance between single photon emission computerized tomography/computerized tomography and fluorescence images. The high and specific accumulation of the dual labeled antibody conjugate in tumors was confirmed in the biodistribution studies. Maximum tumor uptake was observed 1 week after inoculation (mean ± SD 58.5% ± 18.7% vs 5.6% ± 2.3% injected dose per gm for DTPA-G250-IRDye800CW vs NUH-82, respectively). High tumor uptake was also observed at other time points. This study demonstrates the feasibility of dual modality imaging with dual labeled antibody (111)In-DTPA-G250-IRDye800CW in a clear cell renal cell carcinoma model. Results indicate that preoperative and intraoperative detection of carbonic anhydrase IX expressing tumors, positive resection margins and metastasis might be feasible with this approach. Copyright © 2015 American Urological Association Education and Research

  11. Pulse radiolysis studies of liquid heavy water at temperatures up to 250 degrees C

    International Nuclear Information System (INIS)

    Stuart, C.R.; Ouellette, D.C.; Elliot, A.J.

    2002-09-01

    This report documents the rate constants and associated activation energies for the reactions of the primary radical species, e aq - , ·OD and ·D, which are formed during the radiolysis of heavy water within the temperature range 20 to 250 o C. These heavy-water data have been compared with the corresponding information for light water. These kinetic data form part of the database that is required to model the aqueous radiation chemistry that occurs within the core of the heavy water cooled and moderated CANDU reactor. (author)

  12. Pulse radiolysis studies of liquid heavy water at temperatures up to 250 degrees C

    Energy Technology Data Exchange (ETDEWEB)

    Stuart, C.R.; Ouellette, D.C.; Elliot, A.J

    2002-09-01

    This report documents the rate constants and associated activation energies for the reactions of the primary radical species, e{sub aq}{sup -}, {center_dot}OD and {center_dot}D, which are formed during the radiolysis of heavy water within the temperature range 20 to 250 {sup o}C. These heavy-water data have been compared with the corresponding information for light water. These kinetic data form part of the database that is required to model the aqueous radiation chemistry that occurs within the core of the heavy water cooled and moderated CANDU reactor. (author)

  13. Hadron production in 250 GeV/c π+p and K+p interactions

    International Nuclear Information System (INIS)

    Van Hal, P.A.

    1985-01-01

    Results on hadron production in π + p and K + p interactions at 250 GeV/c are presented from the experiment NA22 at the CERN SPS. With the present statistics we find: scaling in the fragmentation regions for both charged and neutral pions; a reasonable description of the K + p→π 0 /π + p→π 0 ratio by both the LUND M.C. and a DTU M.C. (Ranft and Ritter), agreement with these Monte Carlo's for the K + /π + population percentages in the forward hemisphere; no agreement for the seagull with the LUND M.C. and strong disagreement with the DTU M.C

  14. Evaluation of the Performance of Vortex Generators on the DU 91-W2-250 Profile using Stereoscopic PIV

    DEFF Research Database (Denmark)

    Velte, Clara Marika; Hansen, Martin Otto Laver; Meyer, Knud Erik

    2009-01-01

    Stereoscopic PIV measurements investigating the effect of Vortex Generators on the lift force near stall and on glide ratio at best aerodynamic performance have been carried out in the LM Glasfiber wind tunnel on a DU 91-W2-250 profile. Measurements at two Reynolds numbers were analyzed; Re=0...

  15. Evaluation of the Performance of Vortex Generators on the DU 91-W2-250 Profile using Stereoscopic PIV

    DEFF Research Database (Denmark)

    Velte, Clara Marika; Hansen, Martin Otto Laver; Meyer, Knud Erik

    2008-01-01

    Stereoscopic PIV measurements investigating the effect of Vortex Generators on the lift force near stall and on glide ratio at best aerodynamic performance have been carried out in the LM Glasfiber wind tunnel on a DU 91-W2-250 profile. Measurements at two Reynolds numbers were analyzed; Re=0...

  16. A homozygous nonsense CEP250 mutation combined with a heterozygous nonsense C2orf71 mutation is associated with atypical Usher syndrome.

    Science.gov (United States)

    Khateb, Samer; Zelinger, Lina; Mizrahi-Meissonnier, Liliana; Ayuso, Carmen; Koenekoop, Robert K; Laxer, Uri; Gross, Menachem; Banin, Eyal; Sharon, Dror

    2014-07-01

    Usher syndrome (USH) is a heterogeneous group of inherited retinitis pigmentosa (RP) and sensorineural hearing loss (SNHL) caused by mutations in at least 12 genes. Our aim is to identify additional USH-related genes. Clinical examination included visual acuity test, funduscopy and electroretinography. Genetic analysis included homozygosity mapping and whole exome sequencing (WES). A combination of homozygosity mapping and WES in a large consanguineous family of Iranian Jewish origin revealed nonsense mutations in two ciliary genes: c.3289C>T (p.Q1097*) in C2orf71 and c.3463C>T (p.R1155*) in centrosome-associated protein CEP250 (C-Nap1). The latter has not been associated with any inherited disease and the c.3463C>T mutation was absent in control chromosomes. Patients who were double homozygotes had SNHL accompanied by early-onset and severe RP, while patients who were homozygous for the CEP250 mutation and carried a single mutant C2orf71 allele had SNHL with mild retinal degeneration. No ciliary structural abnormalities in the respiratory system were evident by electron microscopy analysis. CEP250 expression analysis of the mutant allele revealed the generation of a truncated protein lacking the NEK2-phosphorylation region. A homozygous nonsense CEP250 mutation, in combination with a heterozygous C2orf71 nonsense mutation, causes an atypical form of USH, characterised by early-onset SNHL and a relatively mild RP. The severe retinal involvement in the double homozygotes indicates an additive effect caused by nonsense mutations in genes encoding ciliary proteins. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  17. Angular distributions of 250 GeV/c positive particles axially channeled in germanium crystal. Pt. 3

    International Nuclear Information System (INIS)

    Sun, C.R.; Gibson, W.M.; Kim, I.J.; Williams, G.O.; Carrigan, R.A. Jr.; Chrisman, B.L.; Toohig, T.E.; Guzik, Z.; Nigmanov, T.S.; Tsyganov, A.S.

    1982-01-01

    Channeling phenomena are observed for charged particles of momentum up to 250 GeV/c in a germanium crystal. The angular distributions of the channeled particles are compared with theoretical predictions based on a diffusion model. The results indicate additional mechanisms leading to dechanneling of the particles although channeling effects are observed for particles incident at up to several times the critical angle, in contrast with the results from low energy channeling. (orig.)

  18. A dense grid of narrow bandpass steep edge filters for the JST/T250 telescope: summary of results

    Science.gov (United States)

    Brauneck, U.; Sprengard, R.; Bourquin, S.; Marín-Franch, A.

    2017-09-01

    On the Javalambre mountain in Spain, the Centro de Estudios de Fisica del Cosmos de Aragon (CEFCA) has setup a new wide field telescope, the JST/T250: a 2.55 m telescope with a plate scale of 22.67"/mm and a 3° diameter field of view. To conduct a photometric sky survey, a large format mosaic camera made of 14 individual CCDs is used in combination with filter trays containing 14 filters each of theses 101.7 x 96.5 mm in size. For this instrument, SCHOTT manufactured 56 specially designed steep edged bandpass interference filters which were recently completed. The filter set consists of bandpass filters in the range between 348,5 nm and 910 nm and a longpass filter at 915 nm. Most of the filters have FWHM of 14.5 nm and a blocking between 250 and 1050 nm with optical density of OD5. Absorptive color glass substrates in combination with interference filters were used to minimize residual reflection in order to avoid ghost images. Inspite of containing absorptive elements, the filters show the maximum possible transmission. This was achieved by using magnetron sputtering for the filter coating process. The most important requirement for the continuous photometric survey is the tight tolerancing of the central wavelengths and FWHM of the filters. This insures each bandpass having a defined overlap with its neighbors. In addition, the blocking of the filters is better than OD5 in the range 250-1050 nm. A high image quality required a low transmitted wavefront error (

  19. 30 CFR 250.181 - When may the Secretary cancel my lease and when am I compensated for cancellation?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When may the Secretary cancel my lease and when... may the Secretary cancel my lease and when am I compensated for cancellation? If the Secretary cancels.... Section 250.185 states conditions under which you will receive no compensation. The Secretary may cancel a...

  20. Evidence for general instability of past climate from a 250-KYR ice-core record

    DEFF Research Database (Denmark)

    Johnsen, Sigfus Johann; Clausen, Henrik Brink; Dahl-Jensen, Dorthe

    1993-01-01

    decades. Here we present a detailed stable-isotope record for the full length of the Greenland Ice-core Project Summit ice core, extending over the past 250 kyr according to a calculated timescale. We find that climate instability was not confined to the last glaciation, but appears also to have been...... results1,2 from two ice cores drilled in central Greenland have revealed large, abrupt climate changes of at least regional extent during the late stages of the last glaciation, suggesting that climate in the North Atlantic region is able to reorganize itself rapidly, perhaps even within a few...

  1. Determination of the sensitivity of Tc-99-NMR-measurements with a 250 MHz-spectrometer

    International Nuclear Information System (INIS)

    Findeisen, M.; Lorenz, B.; Wahren, M.

    1990-01-01

    By means of different concentrations the signal-to-noise ratios of Tc-99-NMR spectra were determined applying well measurable Tc-samples [tetrabutylammonium pertechnetate, TBA (TcO 4 )] and a 250 MHz-spectrometer. The signal-to-noise ratios of the spectra were determined by using the integrated routines of the firm's software and accumulating different number of scans. By fittings of data of the signal-to-noise ratio dependence and by extrapolation the minimum Tc-concentration could be empirically found out. Applying a duration of measurements of 12 hours about 10 -7 molar concentrations can be determined. (orig.) [de

  2. MUSE-INGS ON AM1354-250: COLLISIONS, SHOCKS, AND RINGS

    Energy Technology Data Exchange (ETDEWEB)

    Conn, Blair C. [Gemini Observatory, Recinto AURA, Colina El Pino, Casilla 603, La Serena (Chile); Fogarty, L. M. R. [Sydney Institute for Astronomy, School of Physics, The University of Sydney, A28, Sydney, 2006 (Australia); Smith, Rory [Yonsei University, Graduate School of Earth System Sciences-Astronomy-Atmospheric Sciences, Yonsei-ro 50, Seoul 120-749 (Korea, Republic of); Candlish, Graeme N., E-mail: bconn@gemini.edu [Departamento de Astronomía, Universidad de Concepción, Casilla 160-C, Concepción (Chile)

    2016-03-10

    We present Multi Unit Spectroscopic Explorer observations of AM1354-250, confirming its status as a collisional ring galaxy that has recently undergone an interaction, creating its distinctive shape. We analyze the stellar and gaseous emission throughout the galaxy finding direct evidence that the gaseous ring is expanding with a velocity of ∼70 km s{sup −1} and that star formation is occurring primarily in H ii regions associated with the ring. This star formation activity is likely triggered by this interaction. We find evidence for several excitation mechanisms in the gas, including emission consistent with shocked gas in the expanding ring and a region of LINER-like emission in the central core of the galaxy. Evidence of kinematic disturbance in both the stars and gas, possibly also triggered by the interaction, can be seen in all of the velocity maps. The ring galaxy retains a weak spiral structure, strongly suggesting the progenitor galaxy was a massive spiral prior to the collision with its companion an estimated 140 ± 12 Myr ago.

  3. Simulation of a 250 kW diesel fuel processor/PEM fuel cell system

    Science.gov (United States)

    Amphlett, J. C.; Mann, R. F.; Peppley, B. A.; Roberge, P. R.; Rodrigues, A.; Salvador, J. P.

    Polymer-electrolyte membrane (PEM) fuel cell systems offer a potential power source for utility and mobile applications. Practical fuel cell systems use fuel processors for the production of hydrogen-rich gas. Liquid fuels, such as diesel or other related fuels, are attractive options as feeds to a fuel processor. The generation of hydrogen gas for fuel cells, in most cases, becomes the crucial design issue with respect to weight and volume in these applications. Furthermore, these systems will require a gas clean-up system to insure that the fuel quality meets the demands of the cell anode. The endothermic nature of the reformer will have a significant affect on the overall system efficiency. The gas clean-up system may also significantly effect the overall heat balance. To optimize the performance of this integrated system, therefore, waste heat must be used effectively. Previously, we have concentrated on catalytic methanol-steam reforming. A model of a methanol steam reformer has been previously developed and has been used as the basis for a new, higher temperature model for liquid hydrocarbon fuels. Similarly, our fuel cell evaluation program previously led to the development of a steady-state electrochemical fuel cell model (SSEM). The hydrocarbon fuel processor model and the SSEM have now been incorporated in the development of a process simulation of a 250 kW diesel-fueled reformer/fuel cell system using a process simulator. The performance of this system has been investigated for a variety of operating conditions and a preliminary assessment of thermal integration issues has been carried out. This study demonstrates the application of a process simulation model as a design analysis tool for the development of a 250 kW fuel cell system.

  4. Interaction of nucleic acids with Coomassie Blue G-250 in the Bradford assay.

    Science.gov (United States)

    Wenrich, Broc R; Trumbo, Toni A

    2012-09-15

    The Bradford assay has been used reliably for decades to quantify protein in solution. The analyte is incubated in acidic solution of Coomassie Blue G-250 dye, during which reversible ionic and nonionic binding interactions form. Bradford assay color yields were determined for salmon, bovine, shrimp, and kiwi fruit genomic DNA; baker's yeast RNA; bovine serum albumin (BSA); and hen egg lysozyme. Pure DNA and RNA bound the dye, with color yields of 0.0017 mg⁻¹ cm⁻¹ and 0.0018 mg⁻¹ cm⁻¹, respectively. The nucleic acid-Coomassie Blue response was significant, at roughly 9% of that for BSA and 18% of that for lysozyme. Copyright © 2012 Elsevier Inc. All rights reserved.

  5. Residual Nuclides Induced in Cu Target by a 250 MeV Proton Beam

    International Nuclear Information System (INIS)

    Zhang Hong-Bin; Zhang Xue-Ying; Ma Fei; Ju Yong-Qin; Ge Hong-Lin; Chen Liang; Zhang Yan-Bin; Li Yan-Yan; Luo Peng; Wang Jian-Guo; Wan Bo; Xu Xiao-Wei; Wei Ji-Fang; Zhou Bin

    2015-01-01

    Residual nuclide production is studied experimentally by bombarding a Cu target with a 250 MeV proton beam. The data are measured by the off-line γ-spectroscopy method. Six nuclides are identified and their cross sections are determined. The corresponding calculated results by the MCNPX and GEANT4 codes are compared with the experimental data to check the validity of the codes. A comparison shows that the MCNPX simulation has a better agreement with the experiment. The energy dependence of residual nuclide production is studied with the aid of MCNPX simulation, and it is found that the mass yields for the nuclides in the light mass region increase significantly with the proton energy. (paper)

  6. Simulation of thermal response of the 250 MWT modular HTGR during hypothetical uncontrolled heatup accidents

    International Nuclear Information System (INIS)

    Harrington, R.M.; Ball, S.J.

    1985-01-01

    One of the central design features of the 250 MWT modular HTGR is the ability to withstand uncontrolled heatup accidents without severe consequences. This paper describes calculational studies, conducted to test this design feature. A multi-node thermal-hydraulic model of the 250 MWT modular HTGR reactor core was developed and implemented in the IBM CSMP (Continuous System Modeling Program) simulation language. Survey calculations show that the loss of forced circulation accident with loss of steam generator cooling water and with accidental depressurization is the most severe heatup accident. The peak hot-spot fuel temperature is in the neighborhood of 1600 0 C. Fuel failure and fission product releases for such accidents would be minor. Sensitivity studies show that code input assumptions for thermal properties such as the side reflector conductivity have a significant effect on the peak temperature. A computer model of the reactor vessel cavity concrete wall and its surrounding earth was developed to simulate the extremely unlikely and very slowly-developing heatup accident that would take place if the worst-case loss of forced primary coolant circulation accident were further compounded by the loss of cooling water to the reactor vessel cavity liner cooling system. Results show that the ability of the earth surrounding the cavity to act as a satisfactory long-term heat sink is very sensitive to the assumed rate of decay heat generation and on the effective thermal conductivity of the earth

  7. Square lattice honeycomb tri-carbide fuels for 50 to 250 KN variable thrust NTP design

    International Nuclear Information System (INIS)

    Anghaie, Samim; Knight, Travis; Gouw, Reza; Furman, Eric

    2001-01-01

    Ultrahigh temperature solid solution of tri-carbide fuels are used to design an ultracompact nuclear thermal rocket generating 950 seconds of specific impulse with scalable thrust level in range of 50 to 250 kilo Newtons. Solid solutions of tri-carbide nuclear fuels such as uranium-zirconium-niobium carbide. UZrNbC, are processed to contain certain mixing ratio between uranium carbide and two stabilizing carbides. Zirconium or niobium in the tri-carbide could be replaced by tantalum or hafnium to provide higher chemical stability in hot hydrogen environment or to provide different nuclear design characteristics. Recent studies have demonstrated the chemical compatibility of tri-carbide fuels with hydrogen propellant for a few to tens of hours of operation at temperatures ranging from 2800 K to 3300 K, respectively. Fuel elements are fabricated from thin tri-carbide wafers that are grooved and locked into a square-lattice honeycomb (SLHC) shape. The hockey puck shaped SLHC fuel elements are stacked up in a grooved graphite tube to form a SLHC fuel assembly. A total of 18 fuel assemblies are arranged circumferentially to form two concentric rings of fuel assemblies with zirconium hydride filling the space between assemblies. For 50 to 250 kilo Newtons thrust operations, the reactor diameter and length including reflectors are 57 cm and 60 cm, respectively. Results of the nuclear design and thermal fluid analyses of the SLHC nuclear thermal propulsion system are presented

  8. Optimized production and characterization of a detergent-stable protease from Lysinibacillus fusiformis C250R.

    Science.gov (United States)

    Mechri, Sondes; Kriaa, Mouna; Ben Elhoul Berrouina, Mouna; Omrane Benmrad, Maroua; Zaraî Jaouadi, Nadia; Rekik, Hatem; Bouacem, Khelifa; Bouanane-Darenfed, Amel; Chebbi, Alif; Sayadi, Sami; Chamkha, Mohamed; Bejar, Samir; Jaouadi, Bassem

    2017-08-01

    In this study, we aimed to optimize the cultural and nutritional conditions for protease production by Lysinibacillus fusiformis strain C250R in submerged fermentation process using statistical methodology. The most significant factors (gruel, wheat bran, yeast extract, and FeSO 4 ) were identified by Plackett-Burman design. Response surface methodology (RSM) was used to determine the optimum levels of the screened factors and their interaction. Under the optimized conditions, protease yield 3100U/mL was 4.5 folds higher than those obtained by the use of the initial conditions (680U/mL). Additionally, a new extracellular 51kDa-protease, designated SAPLF, was purified and biochemically characterized from strain C250R. It shows optimum activity at 70°C and pH 10. Its half-life times at 70 and 80°C were 10 and 6-h, respectively. Irreversible inhibition of enzyme activity of SAPLF with serine protease inhibitors demonstrated that it belongs to the serine protease family. Interestingly, its catalytic efficiency was higher than that of SPVP from Aeribacillus pallidus strain VP3 and Alcalase Ultra 2.5L from Bacillus licheniformis. This study demonstrated that SAPLF has a high detergent compatibility and an excellent stain removal compared to Alcalase Ultra 2.5L; which offers an interesting potential for its application in the laundry detergent industry. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Grammaire pour adolescents 250 exercices : niveau débutant

    CERN Document Server

    Bié, Nathalie

    2005-01-01

    Ce nouveau livre d'exercices de grammaire, de la collection Le Nouvel Entraînez-vous, s'adresse à un public d'adolescents débutants et faux débutants en français langue étrangère. L'ouvrage propose 250 exercices de compréhension et de mémorisation à travers des activités de déduction et de réemploi des notions grammaticales étudiées. Le contenu des exercices est organisé autour de contextes langagiers proches de la réalité des adolescents afin de placer la communication au cœur de l'apprentissage. L'introduction des contenus grammaticaux suit la même progression que les méthodes usuelles. Chaque chapitre débute par une séquence Rappel permettant à l'apprenant de revoir rapidement les règles grammaticales développées dans les exercices. Chaque exercice est introduit par une consigne brève et concise accompagnée d'un exemple. L'ouvrage a été conçu en tenant compte des centres d'intérêts des adolescents et propose de nombreuses illustrations intégrées aux exercices. A la fin d...

  10. Studies on Corrosion of Annealed and Aged 18 Ni 250 Grade Maraging Steel in Sulphuric Acid Medium

    OpenAIRE

    Poornima, T.; Jagannatha, Nayak; Shetty, A. Nityananda

    2010-01-01

    The corrosion behavior of aged and annealed sample of 18 Ni 250 grade maraging steel was investigated in varied conditions of concentration and temperature of sulphuric acid medium, using electrochemical techniques like Tafel polarization and electrochemical impedance spectroscopy (EIS). The results obtained from both the techniques are in good agreement. These results have shown increase in corrosion rate of aged specimen with increase in concentration and temperature of sulphuric acid. With...

  11. Analysis of RF section of 250 kW CW C-Band high power klystron

    International Nuclear Information System (INIS)

    Badola, Richa; Kaushik, Meenu; Baloda, Suman; Kirti; Vrati; Lamba, O.S.; Joshi, L.M.

    2012-01-01

    Klystron is a microwave tube which is used as a power amplifier in various applications like radar, particle accelerators and thermonuclear reactors. The paper deals with the analysis of RF section of 250 kW CW C band high power klystron for 50 to 60 kV beam voltage The simulation is done using Poisson's superfish and AJ disk software's Design of cavity is done using superfish. The result of superfish is used to decide the dimensions of the geometry of the cavity and AJ disk is used to determined the centre to centre distances between the cavities in order to obtain the desired powers. (author)

  12. Temperature dependence of the surface energy of mercury from 0 to 250 deg. C

    CERN Document Server

    Halas, S

    2002-01-01

    The surface energy (SE) for mercury was calculated on the basis of the free electron model in which the electron density parameter, r sub s , for bulk electrons was calculated from the density of mercury while the electron density parameter for surface electrons, r sub s sub s , was assumed to be higher by a factor that is linearly dependent on temperature. Ideal agreement of calculated SE values with experimental data was attained for the temperatures 0-250 deg. C assuming that r sub s sub s = r sub s x 1.0021 sup T sup / sup 1 sup 0 sup 0 deg. C. (letter to the editor)

  13. Cardiac ultrastructural changes in rats following 250 Gy whole body. gamma. -irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Yao, Guo; Mingyue, Zhu; Zhiqin, Zhao

    1985-10-01

    Sixteen rats were whole body irradiated with 250 Gy of /sup 60/Co ..gamma..-rays, killed at different intervals after exposure, and then observed by electron microscope. We found lysis of part of myofilaments in specimen obtained at 10 minutes after exposure, and resolution of Z-band at 30 minutes after exposure. These changes were more significant in sections at 12 hours postirradiation, but there also appeared cell regeneration at the same time. The vascular changes were more obvious with the endothelial cytoplasma projected in capillary lumen, nearly obstructing it. All of above described changes may be found in hematologic or intestinal forms of radiation sickness, but they must take place more late after exposure. In cardiovascular form, however, these changes were found as early as 10-30 minutes after exposure; this is a special feature helpful to diagnosis.

  14. HIC1 interacts with a specific subunit of SWI/SNF complexes, ARID1A/BAF250A

    International Nuclear Information System (INIS)

    Van Rechem, Capucine; Boulay, Gaylor; Leprince, Dominique

    2009-01-01

    HIC1, a tumor suppressor gene epigenetically silenced in many human cancers encodes a transcriptional repressor involved in regulatory loops modulating p53-dependent and E2F1-dependent cell survival and stress responses. HIC1 is also implicated in growth control since it recruits BRG1, one of the two alternative ATPases (BRM or BRG1) of SWI/SNF chromatin-remodeling complexes to repress transcription of E2F1 in quiescent fibroblasts. Here, through yeast two-hybrid screening, we identify ARID1A/BAF250A, as a new HIC1 partner. ARID1A/BAF250A is one of the two mutually exclusive ARID1-containing subunits of SWI/SNF complexes which define subsets of complexes endowed with anti-proliferative properties. Co-immunoprecipitation assays in WI38 fibroblasts and in BRG1-/- SW13 cells showed that endogenous HIC1 and ARID1A proteins interact in a BRG1-dependent manner. Furthermore, we demonstrate that HIC1 does not interact with BRM. Finally, sequential chromatin immunoprecipitation (ChIP-reChIP) experiments demonstrated that HIC1 represses E2F1 through the recruitment of anti-proliferative SWI/SNF complexes containing ARID1A.

  15. Apparent Affinity Estimates and Reversal of the Effects of Synthetic Cannabinoids AM-2201, CP-47,497, JWH-122, and JWH-250 by Rimonabant in Rhesus Monkeys.

    Science.gov (United States)

    Hruba, Lenka; McMahon, Lance R

    2017-08-01

    Synthetic cannabinoids have been prohibited due to abuse liability and toxicity. Four such synthetic cannabinoids, AM-2201 ([1-(5-fluoropentyl)indol-3-yl]-naphthalen-1-ylmethanone), CP-47,497 (2-[(1R,3S)-3-hydroxycyclohexyl]-5-(2-methyloctan-2-yl)phenol), JWH-122 [(4-methylnaphthalen-1-yl)-(1-pentylindol-3-yl)methanone], and JWH-250 [2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone], were tested for their capacity to produce CB 1 receptor-mediated discriminative stimulus effects in two groups of rhesus monkeys. One group ( n = 4) discriminated Δ 9 -tetrahydrocannabinol (∆ 9 -THC; 0.1 mg/kg i.v.), and a second group ( n = 4) discriminated the cannabinoid antagonist rimonabant (1 mg/kg i.v.) while receiving 1 mg/kg/12 hours of ∆ 9 -THC. AM-2201, JWH-122, CP-47,497, JWH-250, and ∆ 9 -THC increased ∆ 9 -THC lever responding. Duration of action was 1-2 hours for AM-2201, JWH-122, and JWH-250 and 4-5 hours for CP-47,497 and ∆ 9 -THC. Rimonabant (1 mg/kg) surmountably antagonized the discriminative stimulus effects of all cannabinoid agonists; the magnitude of rightward shift was 10.6-fold for AM-2201, 10.7-fold for JWH-122, 11.0-fold for CP-47,497, and 15.7-fold for JWH-250. The respective pK B values were not significantly different: 6.61, 6.65, 6.66, and 6.83. In ∆ 9 -THC-treated monkeys discriminating rimonabant, AM-2201 (0.1 and 0.32 mg/kg), JWH-122 (0.32 and 1 mg/kg), JWH-250 (1 and 3.2 mg/kg), and CP-47,497 (0.32, 1, and 3.2 mg/kg) produced not only rate-decreasing effects that were reversed by rimonabant, but also dose-dependent, rightward shifts in the rimonabant discrimination dose-effect function. These results show striking similarity in the CB 1 receptor mechanism mediating the subjective effects of AM-2201, JWH-122, JWH-250, and CP-47,497. For products containing AM-2201 and JWH-122, a short duration of action could lead to more frequent use; moreover, inattention to differences in potency among synthetic cannabinoids could underlie unexpected

  16. Inclusive production of π0 mesons in π+p-,K+p- and pp interactions at 250 GeV/c

    International Nuclear Information System (INIS)

    Adamus, M.A.; Azhinenko, I.V.

    1986-01-01

    Data on inclusive π 0 production in the forward hemisphere at Feynman variable (x > 0.025) in the center-of-inertia system in π + p, K + p, and pp interactions at 250 GeV/c are presented. These data are compared to the data at lower energies and interpreted in terms of quark-parton models

  17. 1:250,000-scale Hydrologic Units of the United States

    Science.gov (United States)

    Steeves, Peter; Nebert, Douglas

    1994-01-01

    The Geographic Information Retrieval and Analysis System (GIRAS) was developed in the mid 70s to put into digital form a numberof data layers which were of interest to the USGS. One of these data layers was the Hydrologic Units. The map is based on the Hydrologic Unit Maps published by the U.S. Geological Survey Office of Water Data Coordination, together with the list descriptions and name of region, subregion, accounting units, and cataloging unit. The hydrologic units are encoded with an eight-digit number that indicates the hydrologic region (first two digits), hydrologic subregion (second two digits), accounting unit (third two digits), and cataloging unit (fourth two digits). The data produced by GIRAS was originally collected at a scale of 1:250K. Some areas, notably major cities in the west, were recompiled at a scale of 1:100K. In order to join the data together and use the data in a geographic information system (GIS) the data were processed in the ARC/INFO GUS software package. Within the GIS, the data were edgematched and the neatline boundaries between maps were removed to create a single data set for the conterminous

  18. Coulomb sums for 7Li nucleus at 3-momentum transfers q=1,250...1,625 fm-1

    International Nuclear Information System (INIS)

    Buki, A.Yu.; Shevchenko, N.G.; Timchenko, I.S.

    2009-01-01

    The experimental response functions of 7 Li nucleus at effective 3-momentum transfers q = 1.250; 1.375; 1.500 and 1.625 fm -1 are presented. The longitudinal response functions were used to evaluate the Coulomb sum values. The Coulomb sums for 6 Li obtained by us earlier were applied to analyze these data. The Coulomb sums of lithium isotopes were compared with the well-known Coulomb sums values of the other nuclei

  19. INACTIVATION OF MS2 VIRUS IN DRINKING WATER: ATLANTIC ULTRAVIOLET CORPORATION MEGATRON UNIT, MODEL M250 AT CHULA VISTA, CALIFORNIA

    Science.gov (United States)

    Verification testing of the Atlantic Ultraviolet Megatron M250 system was conducted over a 48-day period from 11/01/01 to 12/18/01. The feedwater to the ultraviolet (UV) unit during the testing was effluent from the Otay Water Treatment Plant (OWTP), a conventional plant with fl...

  20. [Clinical development of acute noise-induced acoustic trauma. An evaluation of a study of 250 cases].

    Science.gov (United States)

    Suc, B; Poulet, M; Asperge, A; Vix, J; Barberot, J P; Doucet, F

    1994-01-01

    Traumatic damage on Cochlea (250 cases) induced by assault gun (F.A.M.A.S.) consists in tinitus and hearing impairement on 6000 Hz. Noise's effects are specific to one Cochlea. Dissociated developments of both tinitus and hearing loss show that their anatomical sites are different. Acoustic injury entails definitive haire cells lesions, cellular biochemical and vascular changes. The treatment that reestablishes or raises cochlear blood flow entails recovery in 80% of cases provided that it is given within 48 hours after the trauma.

  1. Cobalt and molybdenum activated electrodes in foam based alkaline electrolysis cells at 150-250 °C and 40 bar

    DEFF Research Database (Denmark)

    Allebrod, Frank; Chatzichristodoulou, Christodoulos; Mogensen, Mogens Bjerg

    2014-01-01

    A new type of alkaline electrolysis cells with nickel foam based gas diffusion electrodes and KOH (aq) immobilized in mesoporous SrTiO3 has been developed and tested at temperatures of 150 C, 200 C and 250 C at a pressure of 40 bar. Two cells have been characterized during the 270 h long test...

  2. Pre- and post-irradiation properties of copper alloys at 250 deg. C following bonding and bakeout thermal cycles

    International Nuclear Information System (INIS)

    Singh, B.N.; Edwards, D.J.; Eldrup, M.; Toft, P.

    1997-01-01

    Screening experiments were carried out to investigate the effect of bonding and bakeout thermal cycles on microstructure, mechanical properties and electrical resistivity of the oxide dispersion strengthened (GlidCop, CuAl-25) and the precipitation hardened (CuCrZr, CuNiBe) copper alloys. Tensile specimens of CuCrZr and CuNiBe alloys were given various heat treatments corresponding to solution anneal, prime-ageing, and bonding thermal treatment followed by re-ageing and the reactor bakeout treatment at 350 deg. C for 100 h. Tensile specimens of CuAl-25 were given the heat treatment corresponding to the bonding thermal cycle. A number of heat treated specimens were neuron irradiated at 250 deg. C to a dose level of ∼ 0.3 dpa in the DR-3 reactor at Risoe. Both unirradiated and irradiated specimens with various heat treatments were tensile tested at 250 deg. C. The microstructure and electrical resistivity of these specimens were determined in the unirradiated as well as irradiated conditions. The post-deformation microstructure of the irradiated specimens was also investigated. The fracture surfaces of both unirradiated and irradiated specimens were examined. Results of these investigations are reported in the present report. The main effect of the bonding thermal cycle heat treatment was a slight decrease in strength of CuCrZr and CuNiBe alloys. The strength of CuAl-25, on the other hand, remained almost unaltered. The post irradiation tests at 250 deg. C showed a severe loss of ductility in the case of CuNiBe alloy. The irradiated CuAl-25 and CuCrZr specimens, on the other hand, exhibited a reasonable amount of uniform elongation. The results are briefly discussed in terms of thermal and irradiation stability of precipitates and particles and irradiation-induced segregation, precipitation and recovery of dislocation microstructure. (au) 7 tabs., 28 ills., 15 refs

  3. A 250-GHz CARM [Cyclotron Auto Resonance Maser] oscillator experiment driven by an induction linac

    International Nuclear Information System (INIS)

    Caplan, M.; Kulke, B.; Bubp, D.G.; McDermott, D.; Luhmann, N.

    1990-01-01

    A 250-GHz Cyclotron Auto Resonance Maser (CARM) oscillator has been designed and constructed and will be tested using a 1-kA, 2-MeV electron beam produced by the induction linac at the Accelerator Research Center (ARC) facility of Lawrence Livermore National Laboratory (LLNL). The oscillator circuit was made to operate in the TE 11 mode at ten times cutoff using waveguide Bragg reflectors to create an external cavity Q of 8000. Theory predicts cavity fill times of less than 30 ns (pulse length) and efficiencies approaching 20% is sufficiently low transverse electron velocity spreads are maintained (2%)

  4. Design of an induction linac driven CARM [Cyclotron Auto Resonance Maser] oscillator at 250 GHz

    International Nuclear Information System (INIS)

    Caplan, M.; Kulke, B.

    1990-01-01

    We present the design of a 250 GHz, 400 MW Cyclotron Auto Resonance Maser (CARM) oscillator driven by a 1 KA, 2 MeV electron beam produced by the induction linac at the ARC facility of LLNL. The oscillator circuit is designed as a feedback amplifier operating in the TE 11 mode at ten times cutoff terminated at each end with Bragg reflectors. Theory and cold test results are in good agreement for a manufactured Bragg reflector using 50 μm corrugations to ensure mode purity. The CARM is to be operational by February 1990. 3 figs., 2 tabs

  5. Alkaline electrolysis cell at high temperature and pressure of 250 °C and 42 bar

    DEFF Research Database (Denmark)

    Allebrod, Frank; Chatzichristodoulou, Christodoulos; Mogensen, Mogens Bjerg

    2013-01-01

    A new type of alkaline electrolysis cells with nickel foam based gas diffusion electrodes and KOH (aq) immobilized in mesoporous SrTiO3 has been developed and tested at temperatures and pressures up to 250 °C and 42 bar, respectively. Current densities of 1.0 A cm−2 have been measured at a cell v...... voltage of 1.5 V without the use of expensive noble metal catalysts. High electrical efficiency and current density combined with relatively small production costs may lead to both reduced investment and operating costs for hydrogen and oxygen production....

  6. Pierce-Wiggler electron beam system for 250 GHz GYRO-BWO: Final report

    International Nuclear Information System (INIS)

    Pirkle, D.R.; Alford, C.W.; Anderson, M.H.; Garcia, R.F.; Legarra, J.R.; Nordquist, A.L.

    1989-01-01

    This final report summarizes the design and performance of the VUW-8028 Pierce-Wiggler electron beam systems, which can be used to power high frequency gyro-BWO's. The operator's manual for this gyro-BWO beamstick is included as appendix A. Researchers at Lawrence Livermore National Laboratory (LLNL) are developing a gyro-BWO with a center frequency of 250 GHz, 6% bandwidth, and 10 kV peak output power. The gyro-BWO will be used to drive a free electron laser amplifier at LLNL. The electron beam requirements of the gyro-BWO application are: Small beam size, .100 inch at 2500 gauss axial magnetic field; a large fraction of the electron energy in rotational velocity; ability to vary the electrons' axial velocity easily, for electronic tuning; and low velocity spread i.e. little variation in the axial velocities of the electrons in the interaction region. 1 ref., 13 figs

  7. A single CD4 test with 250 cells/mm3 threshold predicts viral suppression in HIV-infected adults failing first-line therapy by clinical criteria.

    Directory of Open Access Journals (Sweden)

    Charles F Gilks

    Full Text Available In low-income countries, viral load (VL monitoring of antiretroviral therapy (ART is rarely available in the public sector for HIV-infected adults or children. Using clinical failure alone to identify first-line ART failure and trigger regimen switch may result in unnecessary use of costly second-line therapy. Our objective was to identify CD4 threshold values to confirm clinically-determined ART failure when VL is unavailable.3316 HIV-infected Ugandan/Zimbabwean adults were randomised to first-line ART with Clinically-Driven (CDM, CD4s measured but blinded or routine Laboratory and Clinical Monitoring (LCM, 12-weekly CD4s in the DART trial. CD4 at switch and ART failure criteria (new/recurrent WHO 4, single/multiple WHO 3 event; LCM: CD4<100 cells/mm(3 were reviewed in 361 LCM, 314 CDM participants who switched over median 5 years follow-up. Retrospective VLs were available in 368 (55% participants.Overall, 265/361 (73% LCM participants failed with CD4<100 cells/mm(3; only 7 (2% switched with CD4≥250 cells/mm(3, four switches triggered by WHO events. Without CD4 monitoring, 207/314 (66% CDM participants failed with WHO 4 events, and 77(25%/30(10% with single/multiple WHO 3 events. Failure/switching with single WHO 3 events was more likely with CD4≥250 cells/mm(3 (28/77; 36% (p = 0.0002. CD4 monitoring reduced switching with viral suppression: 23/187 (12% LCM versus 49/181 (27% CDM had VL<400 copies/ml at failure/switch (p<0.0001. Amongst CDM participants with CD4<250 cells/mm(3 only 11/133 (8% had VL<400 copies/ml, compared with 38/48 (79% with CD4≥250 cells/mm(3 (p<0.0001.Multiple, but not single, WHO 3 events predicted first-line ART failure. A CD4 threshold 'tiebreaker' of ≥250 cells/mm(3 for clinically-monitored patients failing first-line could identify ∼80% with VL<400 copies/ml, who are unlikely to benefit from second-line. Targeting CD4s to single WHO stage 3 'clinical failures' would particularly avoid premature, costly

  8. Downscaling 250-m MODIS growing season NDVI based on multiple-date landsat images and data mining approaches

    Science.gov (United States)

    Gu, Yingxin; Wylie, Bruce K.

    2015-01-01

    The satellite-derived growing season time-integrated Normalized Difference Vegetation Index (GSN) has been used as a proxy for vegetation biomass productivity. The 250-m GSN data estimated from the Moderate Resolution Imaging Spectroradiometer (MODIS) sensors have been used for terrestrial ecosystem modeling and monitoring. High temporal resolution with a wide range of wavelengths make the MODIS land surface products robust and reliable. The long-term 30-m Landsat data provide spatial detailed information for characterizing human-scale processes and have been used for land cover and land change studies. The main goal of this study is to combine 250-m MODIS GSN and 30-m Landsat observations to generate a quality-improved high spatial resolution (30-m) GSN database. A rule-based piecewise regression GSN model based on MODIS and Landsat data was developed. Results show a strong correlation between predicted GSN and actual GSN (r = 0.97, average error = 0.026). The most important Landsat variables in the GSN model are Normalized Difference Vegetation Indices (NDVIs) in May and August. The derived MODIS-Landsat-based 30-m GSN map provides biophysical information for moderate-scale ecological features. This multiple sensor study retains the detailed seasonal dynamic information captured by MODIS and leverages the high-resolution information from Landsat, which will be useful for regional ecosystem studies.

  9. The Undergraduate ALFALFA Team: Outcomes for Over 250 Undergraduate Participants

    Science.gov (United States)

    Troischt, Parker; Koopmann, Rebecca A.; Haynes, Martha P.; ALFALFA Team

    2016-01-01

    The NSF-sponsored Undergraduate ALFALFA (Arecibo Legacy Fast ALFA) Team (UAT) is a consortium of 19 institutions founded to promote undergraduate research and faculty development within the extragalactic ALFALFA HI blind survey project and follow-up programs. In this talk we present outcomes for the more than 250 undergraduate students who have who have participated in the program during the 8 years of funding. 40% of these students have been women and members of underrepresented groups. To date 148 undergraduate students have attended annual workshops at Arecibo Observatory, interacting with faculty, graduate students, their peers, and Arecibo staff in lectures, group activities, tours, and observing runs. Team faculty have supervised 159 summer research projects and 120 academic year (e.g., senior thesis) projects. 68 students have traveled to Arecibo Observatory for observing runs and 55 have presented their results at national meetings such as the AAS. Through participation in the UAT, students are made aware of career paths they may not have previously considered. More than 90% of alumni are attending graduate school and/or pursuing a career in STEM. 42% of those pursuing graduate degrees in Physics or Astronomy are women. This work has been supported by NSF grants AST-0724918/0902211, AST-075267/0903394, AST-0725380, and AST-1211005

  10. The Enduring Legacy of 250 Years of Pharmacology in Edinburgh.

    Science.gov (United States)

    Kelly, John S; Mackay, Angus V P

    2018-01-06

    In 1768, 250 years ago, the University of Edinburgh appointed Francis Home to the first chair of materia medica, the accumulated knowledge of materials used in healing. Francis Home and his colleagues were determined to improve the quality of medical training in Edinburgh by introducing a final examination and compiling a catalog of medicines validated by the Royal College of Physicians of Edinburgh. The catalog, known as the Edinburgh Pharmacopoeia, was a great success, partly due to the orderly nature of its contents, its routine editing to eliminate worthless entries, and the introduction of new treatments whose preparation was precisely documented. In a relatively short time, the worth of the Edinburgh Pharmacopoeia was recognized throughout Europe, America, and the British Empire. Today, the British and European Pharmacopoeias are catalogs of publicly available, legally enforceable standards for active pharmaceutical ingredients and finished dosage forms of pharmaceutical products and medical devices. Home and the many luminaries who succeeded him would surely take pleasure and pride in the fact that the mantra of today's medicines regulators worldwide is little different from that of these early visionaries: "To take better advantage of the best possible science in the service of the public health and our health-care systems" ( 1 , p. 492).

  11. Universal description of inelastic and non(single)-diffractive multiplicity distributions in pp collisions at 250, 360 and 800 GeV/c

    International Nuclear Information System (INIS)

    Krasznovszky, S.; Wagner, I.

    1987-06-01

    A distribution function is proposed for multiplicity in accordance with the stochastic number evolution. This function gives a universal description of inelastic and nondiffractive multiplicity distributions in pp collisions at 250, 360 and 800 GeV/c. The negative binomial distribution fails in the description of inelastic data. (author)

  12. Pairwise comparison of 89Zr- and 124I-labeled cG250 based on positron emission tomography imaging and nonlinear immunokinetic modeling: in vivo carbonic anhydrase IX receptor binding and internalization in mouse xenografts of clear-cell renal cell carcinoma

    International Nuclear Information System (INIS)

    Cheal, Sarah M.; Punzalan, Blesida; Doran, Michael G.; Osborne, Joseph R.; Evans, Michael J.; Lewis, Jason S.; Zanzonico, Pat; Larson, Steven M.

    2014-01-01

    The PET tracer, 124 I-cG250, directed against carbonic anhydrase IX (CAIX) shows promise for presurgical diagnosis of clear-cell renal cell carcinoma (ccRCC) (Divgi et al. in Lancet Oncol 8:304-310, 2007; Divgi et al. in J Clin Oncol 31:187-194, 2013). The radiometal 89 Zr, however, may offer advantages as a surrogate PET nuclide over 124 I in terms of greater tumor uptake and retention (Rice et al. in Semin Nucl Med 41:265-282, 2011). We have developed a nonlinear immunokinetic model to facilitate a quantitative comparison of absolute uptake and antibody turnover between 124 I-cG250 and 89 Zr-cG250 using a human ccRCC xenograft tumor model in mice. We believe that this unique model better relates quantitative imaging data to the salient biological features of tumor antibody-antigen binding and turnover. We conducted experiments with 89 Zr-cG250 and 124 I-cG250 using a human ccRCC cell line (SK-RC-38) to characterize the binding affinity and internalization kinetics of the two tracers in vitro. Serial PET imaging was performed in mice bearing subcutaneous ccRCC tumors to simultaneously detect and quantify time-dependent tumor uptake in vivo. Using the known specific activities of the two tracers, the equilibrium rates of antibody internalization and turnover in the tumors were derived from the PET images using nonlinear compartmental modeling. The two tracers demonstrated virtually identical tumor cell binding and internalization but showed markedly different retentions in vitro. Superior PET images were obtained using 89 Zr-cG250, owing to the more prolonged trapping of the radiolabel in the tumor and simultaneous washout from normal tissues. Estimates of cG250/CAIX complex turnover were 1.35 - 5.51 x 10 12 molecules per hour per gram of tumor (20 % of receptors internalized per hour), and the ratio of 124 I/ 89 Zr atoms released per unit time by tumor was 17.5. Pairwise evaluation of 89 Zr-cG250 and 124 I-cG250 provided the basis for a nonlinear immunokinetic

  13. Desarrollo de la formulación de cefalexina 250 mg granulado para suspensión oral

    Directory of Open Access Journals (Sweden)

    Roxana Martínez Fernández

    2002-04-01

    Full Text Available Se desarrolló la formulación de la cefalexina 250 mg como granulado para suspensión oral. Se utilizó la vía húmeda para la preparación del granulado, teniendo en cuenta los resultados de la caracterización físico-química realizada a las materias primas empleadas. Los resultados de los análisis físico-químicos y microbiológicos del producto terminado fueron satisfactorios. Se realizó un estudio de estabilidad en vida de estante durante 18 meses, con el que se pudo comprobar que la formulación obtenida es estable durante el tiempo estudiado a temperatura entre 15 y 25 °C y durante 7 d después de reconstituido y mantenido en refrigeración. El medicamento cumple con las especificaciones de calidad descritas en la USP 24.The formulation of cephalexin 250 mg was developed as a granulate for oral suspension. The humid way was used for the preparation of the granulate, taking into account the results of the physicochemical characterization of the raw materials used. The results of the physicochemical and microbiological analyses of the finished product were satisfactory. A shelf life stability study was conducted for 18 months that made possible to prove that the formulation obtained was stable during the studied time at temperatures between 15 and 25 ºC and for 7 days after being reconstituted and kept in refrigeration. The drug meets the quality specifications described in the USP 24.

  14. 41 CFR 102-34.250 - Do Federal employees in Government motor vehicles have to use all safety devices and follow all...

    Science.gov (United States)

    2010-07-01

    ... safety devices and follow all safety guidelines? Yes, Federal employees in Government motor vehicles have... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Do Federal employees in Government motor vehicles have to use all safety devices and follow all safety guidelines? 102-34.250 Section...

  15. Energy investments needs are estimated to $250 milliards, 1995-2010, in the South and East Mediterranean countries

    International Nuclear Information System (INIS)

    Calvet, B.

    1996-01-01

    The energy consumption knows a sharper increase in the North and in the East of the Mediterranean sea than in European Union. These trends should continue during the two next decades. From now until 2010, according to the companies predictions, the energy consumption of the free trade future zone countries should continue to strongly increase, to reach near 2 000 millions of petroleum equivalent tons. Then, the financing needs should reach some $250 milliards according to an inquiry of the Energy Mediterranean Observatory. (N.C.)

  16. All that's mine I carry with me. Early life disease and adult health in Sweden during 250 years

    OpenAIRE

    Lindström, Martin

    2015-01-01

    The aim of this thesis is to study early life risk exposures in relation to adult health and mortality in Sweden during 250 years. A number of causal mechanisms by which exposure to diseases and stressful economic and social conditions early in life may lead to increased morbidity and mortality later in life are discussed (paper I). The early life exposures investigated are the foetal origins (nutrition) and the inflammation hypotheses. Longitudinal demographic and socioeconomic data for indi...

  17. SU-E-T-359: Emulation of Yb-169 Gamma-Ray Spectrum Using Metal-Filtered 250 KVp X-Rays for Pre-Clinical Studies of Gold Nanoparticle-Aided Radiation Therapy

    International Nuclear Information System (INIS)

    Reynoso, F; Cho, S

    2015-01-01

    Purpose: To develop an external beam surrogate of the Yb-169 brachytherapy source applying a filter-based spectrum modulation technique to 250 kVp x-rays. In-vitro/vivo studies performed with the modulated 250 kVp beam will help gauge the benefits of implementing gold nanoparticle-aided radiotherapy with the Yb-169 source. Methods: A previously validated MCNP5 model of the Phillips RT-250 orthovoltage unit was used to obtain the percentage depth dose (PDD) and filtered photon spectra for a variety of filtration and irradiation conditions. Photon spectra were obtained using the average flux F4 tally in air right after all collimation. A 30 x 30 x 30 cm 3 water phantom was used to compute the PDD along the central axis (CAX) under the standards conditions of a 10 x 10 cm 2 field size at 50 cm SSD. Cylindrical cells of 4 cm in diameter and the energy deposition F6 tally were used along the CAX to score the doses down to 20 cm depth. The number of particle history was set to 2 x 10 8 in order to keep the relative uncertainty within each cell < 0.3%. The secondary electron spectrum within a gold-loaded tissue due to each photon spectrum was also calculated using EGSnrc and compared with that due to Yb-169 gamma rays. Results: Under the practical constraints for the spectrum modulation task, 250 kVp x-rays filtered by a 0.25 mm Erbium (Er) foil produced the best match with Yb-169 gamma rays, in terms of PDD and, more importantly, secondary electron spectrum. Conclusion: Modulation of 250kVp x-ray spectrum by an Er-filter was found effective in emulating the gamma ray spectrum of Yb-169. Possible benefits as predicted from the current MC model such as enhanced radiosensitization with the Er-filtered beam (as a surrogate of Yb-169) was confirmed with a separate in-vitro study. Supported by DOD/PCRP grant W81XWH-12-1-0198

  18. Complete Set of Deuteron Analyzing Powers for dp Elastic Scattering at 250 MeV/nucleon and Three Nucleon Forces

    Directory of Open Access Journals (Sweden)

    Shimizu Y.

    2010-04-01

    Full Text Available Measurements of a complete set of deuteron analyzing powers (iT11, T20, T21, T22 for elastic deuteron–proton scattering at 250 MeV/nucleon have been performed with polarized deuteron beams at RIKEN RI Beam Factory. The obtained data are compared with the Faddeev calculations based on the modern nucleon–nucleon forces together with the Tucson-Melbourne’99, and UrbanaIX three nucleon forces.

  19. Bioequivalence of 250 mg lysine clonixinate tablets after a single oral dose in a healthy female Mexican population under fasting conditions.

    Science.gov (United States)

    Marcelín-Jiménez, G; Angeles, A C P; García, A; Morales, M; Rivera, L; Martín-Del-Campo, A

    2010-05-01

    To evaluate the bioequivalence between two 250 mg-tablets of lysine clonixinate, Dorixina Forte (Siegfried Rhein, México) as reference product, and Prestodol (Farmaceúticos Rayere, S.A., México) as test formulation. 26 healthy adult female Mexican volunteers received a single oral dose of 250-mg lysine clonixinate under fasting conditions. The drug was administered following a randomized, two-period, two-sequence, cross-over design. Twelve serial blood samples were collected up to 8 h after dosing, and clonixin (CLX) was measured by ultra-performance liquid chromatography (UPLC) coupled with tandem mass spectrometry. Decimal logarithm values of Cmax and area under the curve (AUC) were used to construct a classic confidence interval at 90% (90% CI). Bioequivalence was established if 90% CI of mean ratios (test/reference) fall within the 0.8-1.25 range. Volunteers formed a homogeneous population in terms of age (27.2 +/- 6.3 years), weight (55.9 +/- 6.5 kg), height (1.6 +/- 0.04 m), and body mass index (BMI) (22.91 +/- 2.03 kg/m(2)). Reference formulation exhibited the following pharmacokinetics: C(max) (32.39 +/- 8.32 microg/ml); t(max) (0.64 +/- 0.2 h); AUC0-8h (48.92 +/- 16.51 microg x h/ml); t1/2 (1.3 +/- 0.24 h); CLapp (5.64 +/- 1.99 l/h), and Vdapp (10.22 +/- 2.9 l). Concerning bioequivalence, 90% CI were: C(max) (82.32 - 98.79), AUC0-t (94.59-106.29), and AUC(0-inf) (94.61-106.42), with a statistical power of > 0.90 at every tested interval. This single-dose study found that both 250-mg immediate-release tablets of lysine clonixinate met the Mexican regulatory criteria for bioequivalence in these volunteers.

  20. Soil and Terrain Database for Upper Tana River Catchment (version 1.1) - scale 1:250,000 (SOTER_UT_v1.1)

    NARCIS (Netherlands)

    Dijkshoorn, J.A.; Macharia, P.; Kempen, B.

    2014-01-01

    The Soil and Terrain database for the Upper Tana River Catchment (version 1.1) (SOTER_UT_v1.1) at scale 1:250,000 was compiled to support the Green Water Credits (GWC) programme by creating a primary SOTER dataset for a hydrology assessment of the basin. The Kenya Soil Survey of the Kenya

  1. Neutral strange particle production in π+/K+p interactions at 250 GeV/c

    International Nuclear Information System (INIS)

    Scholten, A.J.

    1988-01-01

    This thesis in which a detailed study of K n inclusive production in K + p and π + p interactions at 250 GeV/c is presented, concentrates on neutral strange interaction products and draws some conclusions about the fate of the strange quark. In ch. 2 the experimental setup is described and in ch. 3 the series of computer programs that perform data reduction. Ch. 4 deals with the selectionn of events and neutral kaons. Also the calculations needed to correct for losses and background are described there. In ch. 5 inclusive and semi-inclusive distributions are presented and compared to data obtained in experiments at lower beam energy. In ch. 6 the data are compared with model predictions. In ch. 7 the main conclusions are summarized. (H.W.). 64 refs.; 39 refs.; 19 tabs

  2. Electrical properties of pseudo-single-crystalline Ge films grown by Au-induced layer exchange crystallization at 250 °C

    Science.gov (United States)

    Higashi, H.; Kudo, K.; Yamamoto, K.; Yamada, S.; Kanashima, T.; Tsunoda, I.; Nakashima, H.; Hamaya, K.

    2018-06-01

    We study the electrical properties of pseudo-single-crystalline Ge (PSC-Ge) films grown by a Au-induced layer exchange crystallization method at 250 °C. By inserting the SiNx layer between PSC-Ge and SiO2, we initiatively suppress the influence of the Ge/SiO2 interfacial defective layers, which have been reported in our previous works, on the electrical properties of the PSC-Ge layers. As a result, we can detect the influence of the ionized Au+ donors on the temperature-dependent hole concentration and Hall mobility. To further examine their electrical properties in detail, we also fabricate p-thin-film transistors (TFTs) with the PSC-Ge layer. Although the off-state leakage currents are suppressed by inserting the SiNx layer, the value of on/off ratio remains poor (leakage current although a nominal field effect mobility is enhanced up to ˜25 cm2/V s. Considering these features, we conclude that the Au contaminations into the PSC-Ge layer can affect the electrical properties and device performances despite a low-growth temperature of 250 °C. To achieve further high-performance p-TFTs, we have to suppress the Au contaminations into PSC-Ge during the Au-induced crystallization growth.

  3. Thermal power calibration of the TRIGA Mark I IPR-R1 reactor during the upgrading tests to 250 kW

    International Nuclear Information System (INIS)

    Mesquita, Amir Zacarias; Maretti, Fausto Junior; Rezende, Hugo Cesar

    2002-01-01

    This paper presents the results and the methodology used to calibrate the thermal power of the TRIGA MARK I IPR-R1 Reactor in CDTN, Belo Horizonte, Brazil. This calibration was realized during the operation tests carried out to allow the reactor power upgrade from the current 100 kW to 250 kW. The methodology consisted in the measurement of the inlet and outlet temperature and the water flow in the primary cooling loop. The thermal balance together with the thermal losses gave the thermal power. There were made three sequences of tests. The first rising of the thermal power was made with the usual configuration of the core (59 fuel elements). After the changing of the ion chambers position and the control rod and the increase of the number of fuels (63 fuel elements), a new evaluation of the thermal power was accomplished, having been obtained a thermal power of 234 kW, for an indication of 250 kW in the lineal channel. After the return of the core to the initial configuration (59 fuel elements), it took place a new test, getting back the reactor to the power level of 100 kW. (author)

  4. Pairwise comparison of {sup 89}Zr- and {sup 124}I-labeled cG250 based on positron emission tomography imaging and nonlinear immunokinetic modeling: in vivo carbonic anhydrase IX receptor binding and internalization in mouse xenografts of clear-cell renal cell carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Cheal, Sarah M.; Punzalan, Blesida; Doran, Michael G.; Osborne, Joseph R. [Memorial Sloan-Kettering Cancer Center, Department of Radiology, New York, NY (United States); Evans, Michael J. [Memorial Sloan-Kettering Cancer Center, Human Oncology and Pathogenesis Program, New York, NY (United States); Lewis, Jason S. [Memorial Sloan-Kettering Cancer Center, Department of Radiology, New York, NY (United States); Memorial Sloan-Kettering Cancer Center, Program in Molecular Pharmacology and Chemistry, New York, NY (United States); Memorial Sloan-Kettering Cancer Center, Radiochemistry and Imaging Sciences Service, New York, NY (United States); Zanzonico, Pat [Memorial Sloan-Kettering Cancer Center, Department of Radiology, New York, NY (United States); Memorial Sloan-Kettering Cancer Center, Molecular Pharmacology and Therapy Service, New York, NY (United States); Memorial-Sloan Kettering Cancer Center, New York, NY (United States); Larson, Steven M. [Memorial Sloan-Kettering Cancer Center, Department of Radiology, New York, NY (United States); Memorial Sloan-Kettering Cancer Center, Program in Molecular Pharmacology and Chemistry, New York, NY (United States); Memorial Sloan-Kettering Cancer Center, Molecular Pharmacology and Therapy Service, New York, NY (United States)

    2014-05-15

    The PET tracer, {sup 124}I-cG250, directed against carbonic anhydrase IX (CAIX) shows promise for presurgical diagnosis of clear-cell renal cell carcinoma (ccRCC) (Divgi et al. in Lancet Oncol 8:304-310, 2007; Divgi et al. in J Clin Oncol 31:187-194, 2013). The radiometal {sup 89}Zr, however, may offer advantages as a surrogate PET nuclide over {sup 124}I in terms of greater tumor uptake and retention (Rice et al. in Semin Nucl Med 41:265-282, 2011). We have developed a nonlinear immunokinetic model to facilitate a quantitative comparison of absolute uptake and antibody turnover between {sup 124}I-cG250 and {sup 89}Zr-cG250 using a human ccRCC xenograft tumor model in mice. We believe that this unique model better relates quantitative imaging data to the salient biological features of tumor antibody-antigen binding and turnover. We conducted experiments with {sup 89}Zr-cG250 and {sup 124}I-cG250 using a human ccRCC cell line (SK-RC-38) to characterize the binding affinity and internalization kinetics of the two tracers in vitro. Serial PET imaging was performed in mice bearing subcutaneous ccRCC tumors to simultaneously detect and quantify time-dependent tumor uptake in vivo. Using the known specific activities of the two tracers, the equilibrium rates of antibody internalization and turnover in the tumors were derived from the PET images using nonlinear compartmental modeling. The two tracers demonstrated virtually identical tumor cell binding and internalization but showed markedly different retentions in vitro. Superior PET images were obtained using {sup 89}Zr-cG250, owing to the more prolonged trapping of the radiolabel in the tumor and simultaneous washout from normal tissues. Estimates of cG250/CAIX complex turnover were 1.35 - 5.51 x 10{sup 12} molecules per hour per gram of tumor (20 % of receptors internalized per hour), and the ratio of {sup 124}I/{sup 89}Zr atoms released per unit time by tumor was 17.5. Pairwise evaluation of {sup 89}Zr-cG250 and {sup

  5. Large self-affine fractality in $\\pi^{+}p$ and $K^{+}p$ collisions at 250 GeV/c

    CERN Document Server

    Agababian, N M

    1996-01-01

    Taking into account the anisotropy of phase space in multiparticle production, a self-affine analysis of factorial moments was carried out on the NA22 data for $\\pi^{+}p$ and $K^{+}p$ collisions at 250 GeV/$c$. Within the transverse plane, the Hurst exponents measuring the anisotropy are consistent with unit value (i.e. no anisotropy). They are, however, only half that value when the longitudinal direction is compared to the transverse ones. Fractality, indeed, turns out to be self-affine rather than self-similar in multiparticle production. In three-dimensional phase space, power-law scaling is observed to be better realized in self-affine than in self-similar analysis.

  6. Tensile behavior of EUROFER ODS steel after neutron irradiation up to 16.3 dpa between 250 and 450 °C

    International Nuclear Information System (INIS)

    Materna-Morris, Edeltraud; Lindau, Rainer; Schneider, Hans-Christian; Möslang, Anton

    2015-01-01

    Highlights: • The first 9%CrWVTa steel (0.5% Y_2O_3), EUROFER ODS HIP, have been neutron irradiated up to 16.3 dpa, between 250 and 450 °C, in the High Flux Reactor (HFR). • After post-irradiation tensile tests, there was not any increase of the upper yield strength or strain localization after irradiation which is typical of RAFM steels. • Initially higher yield strength, R_p_0_._2, and distinctive tensile strength, R_m, of EUROFER ODS HIP compared to EUROFER97 steel. • These values increased due to the neutron irradiation at lower irradiation temperatures. - Abstract: During the development of structural material for future fusion reactors, a 50 kg heat of reduced-activation ferritic-martensitic 9%CrWVTa steel with nanoscaled Y_2O_3-particles, EUROFER97 ODS HIP, was produced using powder metallurgy fabrication technology. This first batch of EUROFER97 ODS HIP and, for comparison, the steel EUROFER97 were prepared for a post-irradiation tensile test program. During neutron irradiation in the HFR (High Flux Reactor, The Netherlands), an accumulated dose of up to 16.3 dpa was reached for 771 days at full power, with the irradiation temperature ranging between 250 and 450 °C. During the post-examinations, all specimens showed the highest tensile strength at lower irradiation temperatures between 250 and 350 °C. However, ODS-alloy and steel were found to clearly differ in the mechanical behavior, which could be documented by fully instrumented tensile tests. In the un-irradiated state, tensile strength of the ODS-alloy already was increased considerably by about 60% compared to the steel. Strengthening was further increased by another 20% after neutron irradiation, but with a much better ductility than observed in the steel. The typical irradiation-induced strain localization of EUROFER97 or RAFM steels could not be observed in the EUROFER97 ODS HIP alloy.

  7. Laboratory calibration of the calcium carbonate clumped isotope thermometer in the 25-250 °C temperature range

    Science.gov (United States)

    Kluge, Tobias; John, Cédric M.; Jourdan, Anne-Lise; Davis, Simon; Crawshaw, John

    2015-05-01

    Many fields of Earth sciences benefit from the knowledge of mineral formation temperatures. For example, carbonates are extensively used for reconstruction of the Earth's past climatic variations by determining ocean, lake, and soil paleotemperatures. Furthermore, diagenetic minerals and their formation or alteration temperature may provide information about the burial history of important geological units and can have practical applications, for instance, for reconstructing the geochemical and thermal histories of hydrocarbon reservoirs. Carbonate clumped isotope thermometry is a relatively new technique that can provide the formation temperature of carbonate minerals without requiring a priori knowledge of the isotopic composition of the initial solution. It is based on the temperature-dependent abundance of the rare 13C-18O bonds in carbonate minerals, specified as a Δ47 value. The clumped isotope thermometer has been calibrated experimentally from 1 °C to 70 °C. However, higher temperatures that are relevant to geological processes have so far not been directly calibrated in the laboratory. In order to close this calibration gap and to provide a robust basis for the application of clumped isotopes to high-temperature geological processes we precipitated CaCO3 (mainly calcite) in the laboratory between 23 and 250 °C. We used two different precipitation techniques: first, minerals were precipitated from a CaCO3 supersaturated solution at atmospheric pressure (23-91 °C), and, second, from a solution resulting from the mixing of CaCl2 and NaHCO3 in a pressurized reaction vessel at a pressure of up to 80 bar (25-250 °C).

  8. Molecular hydrogen in the z = 2.811 absorbing material toward the quasar PKS 0528-250

    International Nuclear Information System (INIS)

    Levshakov, S.A.; Varshalovich, D.A.

    1985-01-01

    Among the previously unidentified absorbtion features in the spectrum of the quasar PKS 0528-250 obtained by previous authors tentative evidence has been found for H 2 lines at the same redshift (z = 2.811) as that of the well-known absorption-line system. The column density of molecules has been estimated from the curve of growth; the fraction of H 2 appears to be about 2 x 10 -5 . The ortho- to para-H 2 ratio corresponds to the excitation temperature of Tsub(ex)(H 2 ) = 300 +- 150 K, though the upper rotational levels J >= 3 turn out be overpopulated. The results obtained seem to provide substantial evidence for the existence of molecular hydrogen at the early cosmological epoch with z approx. 3. (author)

  9. A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation

    International Nuclear Information System (INIS)

    Wiegand, Kimberly C; Lu, Yiling; Zhang, Fan; Anglesio, Michael S; Gilks, Blake; Mills, Gordon B; Huntsman, David G; Carey, Mark S; Hennessy, Bryan T; Leung, Samuel; Wang, Yemin; Ju, Zhenlin; McGahren, Mollianne; Kalloger, Steve E; Finlayson, Sarah; Stemke-Hale, Katherine

    2014-01-01

    Ovarian cancer is now recognized as a number of distinct diseases primarily defined by histological subtype. Both clear cell ovarian carcinomas (CCC) and ovarian endometrioid carcinomas (EC) may arise from endometriosis and frequently harbor mutations in the ARID1A tumor suppressor gene. We studied the influence of histological subtype on protein expression with reverse phase protein array (RPPA) and assessed proteomic changes associated with ARID1A mutation/BAF250a expression in EC and CCC. Immunohistochemistry (IHC) for BAF250a expression was performed on 127 chemotherapy-naive ovarian carcinomas (33 CCC, 29 EC, and 65 high-grade serous ovarian carcinomas (HGSC)). Whole tumor lysates were prepared from frozen banked tumor samples and profiled by RPPA using 116 antibodies. ARID1A mutations were identified by exome sequencing, and PIK3CA mutations were characterized by MALDI-TOF mass spectrometry. SAM (Significance Analysis of Microarrays) was performed to determine differential protein expression by histological subtype and ARID1A mutation status. Multivariate logistic regression was used to assess the impact of ARID1A mutation status/BAF250a expression on AKT phosphorylation (pAKT). PIK3CA mutation type and PTEN expression were included in the model. BAF250a knockdown was performed in 3 clear cell lines using siRNA to ARID1A. Marked differences in protein expression were observed that are driven by histotype. Compared to HGSC, SAM identified over 50 proteins that are differentially expressed in CCC and EC. These included PI3K/AKT pathway proteins, those regulating the cell cycle, apoptosis, transcription, and other signaling pathways including steroid hormone signaling. Multivariate models showed that tumors with loss of BAF250a expression showed significantly higher levels of AKT-Thr 308 and AKT-Ser 473 phosphorylation (p < 0.05). In 31 CCC cases, pAKT was similarly significantly increased in tumors with BAF250a loss on IHC. Knockdown of BAF250a by siRNA in

  10. Relative bioavailability of generic and branded 250-mg and 500-mg oral chlorphenesin carbamate tablets in healthy Korean volunteers: a single-dose, randomized-sequence, open-label, two-period crossover trial.

    Science.gov (United States)

    Yu, Ji-young; Song, Hyun Ho; Kim, Bo Gyeom; Park, Hyeon Ju; Choi, Kwang Sik; Kwon, Young Ee

    2009-11-01

    Chlorphenesin carbamate is a skeletal muscle relaxant approved in Korea for use in the treatment of pain and discomfort related to skeletal muscle trauma and inflammation. The aim of this study was to assess the bioequivalence of a generic formulation of chlorphenesin carbamate at doses of 250 and 500 mg and 2 branded formulations of the same doses in healthy Korean adults. This single-dose, randomized-sequence, open-label, 2-period crossover study was conducted in healthy Korean male and female volunteers. Subjects were assigned to receive, in a randomized sequence, a single dose of the generic (test) and branded (reference) formulations of chlorphenesin carbamate at a dose of 250 or 500 mg. Blood samples were drawn at 0, 0.33, 0.67, 1, 1.5, 2, 3, 4, 6, 9, 12, and 15 hours after administration. Pharmacokinetic properties (C(max), T(max), AUC(0-t) AUC(0-infinity), t(1/2), and ke) were determined using HPLC. The formulations were to be considered bioequivalent if the 90% CIs of the treatment ratios of the geometric means of C(max) and AUC(0-t) were within a predetermined range of log 0.80 to log 1.25 based on regulatory criteria. Tolerability was assessed by monitoring for adverse events (AEs) on physical examination and/or e-mail and personal interview at the beginning and end of each study period. Twenty-eight subjects (22 men, 6 women) received chlorphenesin carbamate at the 250-mg dose, and 24 male subjects received the 500-mg dose. The mean (SD) ages of the subjects were 24.0 (2.6) and 24.0 (1.9) years in the 250- and 500-mg groups, respectively. No significant differences were found between the test and reference formulations (90% CIs: C(max), 1.0048-1.1153 with the 250-mg dose and 0.9630-1.1189 with the 500-mg dose; AUC(0-t), 0.9882-1.0546 and 0.9842-1.0578, respectively). No clinically significant AEs (upper gastric pain, abdominal bloating, pyrexia, edema, nausea, heartburn, constipation, headache, dizziness, drowsiness, or fatigue) were reported throughout

  11. Self-affine scaling from non-integer phase-space partition in $\\pi^{+}p$ and $K^{+}p$ collisions at 250 GeV/$c$

    CERN Document Server

    Agababian, N M

    1998-01-01

    A factorial-moment analysis with real (integer and non-integer) phase space partition is applied to $\\pi^+$p and K$^+$p collisions at 250 GeV/$c$. Clear evidence is shown for self-affine rather than self-similar power-law scaling in multiparticle production. The three-dimensional self-affine second-order scaling exponent is determined to be 0.061$\\pm$0.010.

  12. A Versatile High Speed 250 MHz Pulse Imager for Biomedical Applications

    Science.gov (United States)

    Epel, Boris; Sundramoorthy, Subramanian V.; Mailer, Colin; Halpern, Howard J.

    2009-01-01

    A versatile 250 MHz pulse electron paramagnetic resonance (EPR) instrument for imaging of small animals is presented. Flexible design of the imager hardware and software makes it possible to use virtually any pulse EPR imaging modality. A fast pulse generation and data acquisition system based on general purpose PCI boards performs measurements with minimal additional delays. Careful design of receiver protection circuitry allowed us to achieve very high sensitivity of the instrument. In this article we demonstrate the ability of the instrument to obtain three dimensional images using the electron spin echo (ESE) and single point imaging (SPI) methods. In a phantom that contains a 1 mM solution of narrow line (16 μT, peak-to-peak) paramagnetic spin probe we achieved an acquisition time of 32 seconds per image with a fast 3D ESE imaging protocol. Using an 18 minute 3D phase relaxation (T2e) ESE imaging protocol in a homogeneous sample a spatial resolution of 1.4 mm and a standard deviation of T2e of 8.5% were achieved. When applied to in vivo imaging this precision of T2e determination would be equivalent to 2 torr resolution of oxygen partial pressure in animal tissues. PMID:19924261

  13. Customized broadband Sloan-filters for the JST/T250 and JAST/T80 telescopes: measurement summary

    Science.gov (United States)

    Brauneck, Ulf; Sprengard, Ruediger; Bourquin, Sebastien; Marín-Franch, Antonio

    2018-01-01

    The Centro de Estudios de Fisica del Cosmos de Aragon will conduct a photometric sky survey with two new telescopes recently set up on the Javalambre mountain in Spain: the JST/T250 is a 2.55-m telescope with a plate scale of 22.67 arc⁢sec/mm and a 3-deg-diameter field of view (FoV) and the auxiliary telescope JAST/T80 with a 82-cm primary mirror and an FoV of 2 deg diameter. A multiple CCD (9k-by-9k array size, 10-μm pixel size) mosaic camera is used in combination with filter trays or filter wheels, each containing a multitude of filters in dimensions of 101.7×96.5 mm or 106.8×106.8 mm. For this project, Schott manufactured 56 specially designed narrow band steep-edged bandpass interference filters and five broadband Sloan-filters which were completed only recently. We report here on the results of the broadband Sloan-filters with transmission bands of 324 to 400 nm (Sloan-u), 400 to 550 nm (Sloan-g), 550 to 700 nm (Sloan-r), 695 to 850 nm (Sloan-i), and 830 to 1200 nm (Sloan-z). The filters are composed of Schott filterglasses and clearglass substrates coated with interference filters and represent an improvement of broadband Sloan filters commonly used in astronomy. In spite of the absorptive elements, the filters show maximum possible transmissions achieved by magnetron sputtered filter coatings. In addition, the blocking of the filters is better than OD5 (transmission <10 to -5) in the range 250 to 1050 nm which was achieved by combining up to three substrates. A high image quality required a low transmitted wavefront error (<λ/8 locally, respectively <λ/2 globally). We report on the spectral and interferometric results measured on the filters.

  14. Changes of regional climate variability in central Europe during the past 250 years

    Science.gov (United States)

    Böhm, R.

    2012-05-01

    The paper uses the data potential of very long and homogenized instrumental climate time series in the south central Europe for analyzing one feature which is very dominant in the climate change debate --whether anthropogenic climate warming causes or goes along with an increase of climate extremes. The monthly resolved data of the HISTALP data collection provide 58 single series for the three climate elements, air pressure, air temperature and precipitation, that start earlier than 1831 and extend back to 1760 in some cases. Trends and long-term low frequent climate evolution is only shortly touched in the paper. The main goal is the analysis of trends or changes of high frequent interannual and interseasonal variability. In other words, it is features like extremely hot summers, very cold winters, excessively dry or wet seasons which the study aims at. The methods used are based on detrended highpass series whose variance is analyzed in discrete 30-year windows moving over the entire instrumental period. The analysis of discrete subintervals relies on the unique number of 8 (for precipitation 7) such "normal periods". The second approach is based on the same subintervals though not in fixed but moving windows over the entire instrumental period. The first result of the study is the clear evidence that there has been no increase of variability during the past 250 years in the region. The second finding is similar but concentrates on the recent three decades which are of particular interest because they are the first 30 years with dominating anthropogenic greenhouse gas forcing. We can show that also this recent anthropogenic normal period shows no widening of the PDF (probability density function) compared to the preceding ones. The third finding is based on the moving window technique. It shows that interannual variability changes show a clear centennial oscillating structure for all three climate elements in the region. For the time being we have no explanation

  15. Magnetoresistance properties of Fe0,2C0,8 composite materials pre and post gamma irradiated at 250 kGy dose

    International Nuclear Information System (INIS)

    Yunasfi; Setyo Purwanto; Wisnu A A

    2009-01-01

    Research about change of, magnetoresistance properties of Fe 0,2 C 0,8 composite materials pre and post gamma irradiation at a dose of 250 kGy was carried out. Fe 0,2 C 0,8 was prepared by mixing of Fe and C powder with the ratio of Fe : C set on 20:80 in weight %. In this research, the phase structure and magnetic properties of Fe 0,2 C 0,8 composite materials after 250 KGy dose of gamma irradiation have been measured and analyzed. The phase structure of Fe 0,2 C 0,8 was analyzed using X-ray diffractometer (XRD), whole the magnetoresistance properties was characterized using Four Point Probe method. The analyzing results showed the decreasing of X-ray diffraction peak intensity, but also in the same time showed the increasing of magnetoresistance properties after gamma irradiation. The enhancement of magnetoresistance value reached 5 times at 7,5 kOe magnetic field. This enhancement was caused due to structure defect within Fe 0,2 C 0,8 composite initiated by interaction between radiation of gamma ray and composite materials that further causes a change of magnetic interaction intensity in this materials. (author)

  16. Tensile behavior of RAFM alloys after neutron irradiation of up to 16.3 dpa between 250 and 450 °C

    International Nuclear Information System (INIS)

    Materna-Morris, E.; Schneider, H.-C.; Möslang, A.

    2014-01-01

    Tensile specimen of steel EUROFER97 and other alloys on the basis of RAFM steels such, as OPTIFER and F82H alloys, and Ga3X were irradiated and post-examined during a neutron irradiation program of up to 16.3 dpa between 250 and 450 °C in the HFR (High Flux Reactor) in the Netherlands. These tensile results were compared with former irradiation programs, with lower neutron doses of up to 0.8 and 2.4 dpa to quantify the difference in tensile strengthening. The average increase of tensile strength was in a range of 300 MPa between 0.8 and 16.3 dpa at temperatures of 250–300 °C. This behavior can be correlated with irradiation-induced changes in the microstructure. Most of the hardening can be attributed to dislocation loops, point defects or small precipitates as observed in boron-free alloys as F82H mod. and EUROFER97. Whereas the hardening in boron-containing alloys OPTIFER alloys and Ga3X can be correlated in addition with the combination of helium bubbles. At the highest irradiation and test temperature at 450 °C, all tensile data of all investigated materials were in the range of those of non-irradiated and irradiated material due to thermal aging effects

  17. Tensile behavior of RAFM alloys after neutron irradiation of up to 16.3 dpa between 250 and 450 °C

    Energy Technology Data Exchange (ETDEWEB)

    Materna-Morris, E., E-mail: edeltraud.materna-morris@kit.edu; Schneider, H.-C., E-mail: hans-christian.schneider@kit.edu; Möslang, A., E-mail: anton.moeslang@kit.edu

    2014-12-15

    Tensile specimen of steel EUROFER97 and other alloys on the basis of RAFM steels such, as OPTIFER and F82H alloys, and Ga3X were irradiated and post-examined during a neutron irradiation program of up to 16.3 dpa between 250 and 450 °C in the HFR (High Flux Reactor) in the Netherlands. These tensile results were compared with former irradiation programs, with lower neutron doses of up to 0.8 and 2.4 dpa to quantify the difference in tensile strengthening. The average increase of tensile strength was in a range of 300 MPa between 0.8 and 16.3 dpa at temperatures of 250–300 °C. This behavior can be correlated with irradiation-induced changes in the microstructure. Most of the hardening can be attributed to dislocation loops, point defects or small precipitates as observed in boron-free alloys as F82H mod. and EUROFER97. Whereas the hardening in boron-containing alloys OPTIFER alloys and Ga3X can be correlated in addition with the combination of helium bubbles. At the highest irradiation and test temperature at 450 °C, all tensile data of all investigated materials were in the range of those of non-irradiated and irradiated material due to thermal aging effects.

  18. Crystal structures of iron bearing tetrahedrite and tennantite at 25 and 250 degrees C by means of Rietveld refinement of synchrotron data

    DEFF Research Database (Denmark)

    Friese, K.; Grzechnik, A.; Makovicky, E.

    2008-01-01

    Rietveld refinement of X-ray synchrotron data was performed for two synthetic tetrahedrite samples, with 0.61 and 1.83 Fe atoms, and two synthetic tennantite samples with 0.10 and 1.23 Fe atoms p.f.u. M-12(Sb,As)(4)S-13. Measurements were performed at 25 and 250 degrees C. For both the phases...

  19. Crop Dominance Mapping with IRS-P6 and MODIS 250-m Time Series Data

    Directory of Open Access Journals (Sweden)

    Murali Krishna Gumma

    2014-04-01

    Full Text Available This paper describes an approach to accurately separate out and quantify crop dominance areas in the major command area in the Krishna River Basin. Classification was performed using IRS-P6 (Indian Remote Sensing Satellite, series P6 and MODIS eight-day time series remote sensing images with a spatial resolution of 23.6 m, 250 m for the year 2005. Temporal variations in the NDVI (Normalized Difference Vegetation Index pattern obtained in crop dominance classes enables a demarcation between long duration crops and short duration crops. The NDVI pattern was found to be more consistent in long duration crops than in short duration crops due to the continuity of the water supply. Surface water availability, on the other hand, was dependent on canal water release, which affected the time of crop sowing and growth stages, which was, in turn, reflected in the NDVI pattern. The identified crop-wise classes were tested and verified using ground-truth data and state-level census data. The accuracy assessment was performed based on ground-truth data through the error matrix method, with accuracies from 67% to 100% for individual crop dominance classes, with an overall accuracy of 79% for all classes. The derived major crop land areas were highly correlated with the sub-national statistics with R2 values of 87% at the mandal (sub-district level for 2005–2006. These results suggest that the methods, approaches, algorithms and datasets used in this study are ideal for rapid, accurate and large-scale mapping of paddy rice, as well as for generating their statistics over large areas. This study demonstrates that IRS-P6 23.6-m one-time data fusion with MODIS 250-m time series data is very useful for identifying crop type, the source of irrigation water and, in the case of surface water irrigation, the way in which it is applied. The results from this study have assisted in improving surface water and groundwater irrigated areas of the command area and also

  20. Shotgun metagenomics of 250 adult twins reveals genetic and environmental impacts on the gut microbiome

    DEFF Research Database (Denmark)

    Xie, Hailiang; Guo, Ruijin; Zhong, Huanzi

    2016-01-01

    The gut microbiota has been typically viewed as an environmental factor for human health. Twins are well suited for investigating the concordance of their gut microbiomes and decomposing genetic and environmental influences. However, existing twin studies utilizing metagenomic shotgun sequencing...... have included only a few samples. Here, we sequenced fecal samples from 250 adult twins in the TwinsUK registry and constructed a comprehensive gut microbial reference gene catalog. We demonstrate heritability of many microbial taxa and functional modules in the gut microbiome, including those...... associated with diseases. Moreover, we identified 8 million SNPs in the gut microbiome and observe a high similarity in microbiome SNPs between twins that slowly decreases after decades of living apart. The results shed new light on the genetic and environmental influences on the composition and function...

  1. Tightening unit EZ 250 for VVER 1000 type reactor pressure vessel head flange joints

    International Nuclear Information System (INIS)

    Ruchar, Miloslav; Nadenik, Tomas; Kroj, Ludek

    2010-01-01

    The programme of flange joints tightening by seals made of expanded graphite for VVER 440 and VVER 1000 reactor head flange joints is highlighted, and tightening units of row EZ 650 and EZ 650 TK and KNI for VVER 440 reactor head flange joints and EZ 250 tightening unit for VVER 1000 reactor head flange joints are described in detail. The main advantages of electronically controlled tightening units include: Precise and uniform compression of the gasket during the tightening procedure; Automated solution to the graphite relaxing problem during tightening; Possibility of diagnosis of the thread status of the joints being tightened; Alleviation of operator's tough work; Shorter time of tensioning associated with a lower collective doses; Quick preparation of tightening procedure report from the data measured; Calibration renewal is possible in advance at time of unit storage without the need to place it on a real joint. (P.A.)

  2. Conceptual design of the superconducting magnet for the 250 MeV proton cyclotron.

    Science.gov (United States)

    Ren, Yong; Liu, Xiaogang; Gao, Xiang

    2016-01-01

    The superconducting cyclotron is of great importance to treat cancer parts of the body. To reduce the operation costs, a superconducting magnet system for the 250 MeV proton cyclotron was designed to confirm the feasibility of the superconducting cyclotron. The superconducting magnet system consists of a pair of split coils, the cryostat and a pair of binary high temperature superconductor current leads. The superconducting magnet can reach a central magnetic field of about 1.155 T at 160 A. The three GM cryocooler with cooling capacities of 1.5 W at 4.5 K and 35 W at 50 K and one GM cryocooler of 100 W at 50 K were adopted to cool the superconducting magnet system through the thermosiphon technology. The four GM cryocoolers were used to cool the superconducting magnet to realize zero evaporation of the liquid helium.

  3. Measurements of the n->d scattering at 250 MeV and three-nucleon forces

    International Nuclear Information System (INIS)

    Maeda, Y.; Sakai, H.; Fujita, K.; Hatano, M.; Kamiya, J.; Kawabata, T.; Kuboki, H.; Hatanaka, K.; Okamura, H.; Saito, T.; Sakemi, Y.; Sasano, M.; Sekiguchi, K.; Shimizu, Y.; Suda, K.; Tameshige, Y.; Tamii, A.; Wakasa, T.; Yako, K.; Greenfield, M.B.; Kamada, H.; Witala, H.

    2007-01-01

    The differential cross sections and the vector analyzing powers for the nd elastic scattering at E n = 250 MeV have been measured for the study of the three-nucleon force (3NF) effects in the Coulomb-free system. To cover a wide angular region, the experiments were performed by using two different methods at the (n, p) facility and at the NTOF facility which constructed at the Research Center for Nuclear Physics (RCNP). The results were compared with theoretical predictions of the Faddeev calculations based on the modern nucleon-nucleon (NN) forces with the three-nucleon force (3NF). The inclusion of 3NFs leads to a good description of the cross section except for the backward angles. The results were also compared with the theoretical predictions with relativistic corrections. The direct data-to-data comparison of the cross sections of the nd and pd was performed

  4. The onset of star formation 250 million years after the Big Bang

    Science.gov (United States)

    Hashimoto, Takuya; Laporte, Nicolas; Mawatari, Ken; Ellis, Richard S.; Inoue, Akio K.; Zackrisson, Erik; Roberts-Borsani, Guido; Zheng, Wei; Tamura, Yoichi; Bauer, Franz E.; Fletcher, Thomas; Harikane, Yuichi; Hatsukade, Bunyo; Hayatsu, Natsuki H.; Matsuda, Yuichi; Matsuo, Hiroshi; Okamoto, Takashi; Ouchi, Masami; Pelló, Roser; Rydberg, Claes-Erik; Shimizu, Ikkoh; Taniguchi, Yoshiaki; Umehata, Hideki; Yoshida, Naoki

    2018-05-01

    A fundamental quest of modern astronomy is to locate the earliest galaxies and study how they influenced the intergalactic medium a few hundred million years after the Big Bang1-3. The abundance of star-forming galaxies is known to decline4,5 from redshifts of about 6 to 10, but a key question is the extent of star formation at even earlier times, corresponding to the period when the first galaxies might have emerged. Here we report spectroscopic observations of MACS1149-JD16, a gravitationally lensed galaxy observed when the Universe was less than four per cent of its present age. We detect an emission line of doubly ionized oxygen at a redshift of 9.1096 ± 0.0006, with an uncertainty of one standard deviation. This precisely determined redshift indicates that the red rest-frame optical colour arises from a dominant stellar component that formed about 250 million years after the Big Bang, corresponding to a redshift of about 15. Our results indicate that it may be possible to detect such early episodes of star formation in similar galaxies with future telescopes.

  5. Transuranium elements: Past, present, and future

    International Nuclear Information System (INIS)

    Seaborg, G.T.

    1995-01-01

    In this illustrative Account the authors shall concentrate on four of these elements, chosen for their current interest or pivotal role. The story of plutonium is one of the most dramatic in the history of science, and today, plutonium is at the focus of an extraordinary dilemma. Mendelevium (element 101) has played a pivotal role in blazing the trail for the discovery of the heaviest elements on the basis of open-quotes one atom at a timeclose quotes production. Seaborgium (element 106) was recently named in my honor by the discoverers and may be the last element, at least for some time, for which it will be possible to determine many chemical properties. And element 110 represents recent evidence, after a lapse of 10 years, for the discovery of a chemical element. Recent (1994) recommendations of the IUPAC Commission on the Nomenclature of Inorganic Chemistry for the renaming of elements 104-108 have met with widespread rejection. The author is using the names proposed by the acknowledged discoverers (elements 106-109) or, in the case of the disputed elements 104 and 105, the most logical names. 21 refs., 5 figs

  6. Assessment of CD4+ T cell responses to glutamic acid decarboxylase 65 using DQ8 tetramers reveals a pathogenic role of GAD65 121-140 and GAD65 250-266 in T1D development.

    Directory of Open Access Journals (Sweden)

    I-Ting Chow

    Full Text Available Susceptibility to type 1 diabetes (T1D is strongly associated with MHC class II molecules, particularly HLA-DQ8 (DQ8: DQA1*03:01/DQB1*03:02. Monitoring T1D-specific T cell responses to DQ8-restricted epitopes may be key to understanding the immunopathology of the disease. In this study, we examined DQ8-restricted T cell responses to glutamic acid decarboxylase 65 (GAD65 using DQ8 tetramers. We demonstrated that GAD65 121-140 and GAD65 250-266 elicited responses from DQ8+ subjects. Circulating CD4+ T cells specific for these epitopes were detected significantly more often in T1D patients than in healthy individuals after in vitro expansion. T cell clones specific for GAD65 121-140 and GAD65 250-266 carried a Th1-dominant phenotype, with some of the GAD65 121-140-specific T cell clones producing IL-17. GAD65 250-266-specific CD4+ T cells could also be detected by direct ex vivo staining. Analysis of unmanipulated peripheral blood mononuclear cells (PBMCs revealed that GAD65 250-266-specific T cells could be found in both healthy and diabetic individuals but the frequencies of specific T cells were higher in subjects with type 1 diabetes. Taken together, our results suggest a proinflammatory role for T cells specific for DQ8-restricted GAD65 121-140 and GAD65 250-266 epitopes and implicate their possible contribution to the progression of T1D.

  7. [Jonathan Swift's asylum in Dublin--Ireland's introduction to institutional psychiatry 250 years ago].

    Science.gov (United States)

    Reuber, M

    1995-09-01

    250 years ago, the satirical writer and clergyman Jonathan Swift from Dublin (1667-1745) founded the first Irish lunatic asylum. Rejecting the theories put forward by the English philosopher Thomas Hobbes and the doctor Thomas Willis, he was influenced by the ideas of the Scottish doctor and the "enlightened" thinker John Locke. Swift's St. Patrick's Hospital did not, however, realise a new philosophical concept: architecture and therapeutic approach of the new institution were clearly modelled on the much older Hospital of St. Mary of Bethlehem ( = Bedlam). Despite its conservative conceptual basis, the first institution dedicated to the mentally ill and intellectually subnormal in Ireland became a starting point for the apparantly unstoppable expansion of the, at one time, most comprehensive asylum system in the world. After Swift's Hospital had been enlarged twice at the tax-payers' expense (1778, 1793), the administration decided to relieve the institution by erecting the Richmond Asylum (1810), the first public asylum in Ireland. When this establishment also became overcrowded, in 1817, legislation was passed which led to the establishment of the oldest system of public asylums in Europe.

  8. Recent results on the neutron irradiation of ITER candidate copper alloys irradiated in DR-3 at 250{degrees}C to 0.3 dpa

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, D.J. [Pacific Northwest National Lab., Richland, WA (United States); Singh, B.N.; Toft, P.; Eldrup, M.

    1997-04-01

    Tensile specimens of CuCrZr and CuNiBe alloys were given various heat treatments corresponding to solution anneal, prime-ageing and bonding thermal treatment with additional specimens re-aged and given a reactor bakeout treatment at 350{degrees}C for 100 h. CuAl-25 was also heat treated to simulate the effects of a bonding thermal cycle on the material. A number of heat treated specimens were neutron irradiated at 250{degrees}C to a dose level of {approximately}0.3 dpa in the DR-3 reactor as Riso. The main effect of the bonding thermal cycle heat treatment was a slight decrease in strength of CuCrZr and CuNiBe alloys. The strength of CuAl-25, on the other hand, remained almost unaltered. The post irradiation tests at 250{degrees}C showed a severe loss of ductility in the case of the CuNiBe alloy. The irradiated CuAl-25 and CuCrZr specimens exhibited a reasonable amount of uniform elongation, with CuCrZr possessing a lower strength.

  9. Possible experimental studies of the t anti t threshold region at 250--500 GeV e+e- collider

    International Nuclear Information System (INIS)

    Komamiya, Sachio.

    1991-01-01

    A possible measurement of the top quark mass by an energy scan of the t anti t threshold region at e + e - colliders of √s = 250--500 GeV is discussed. With an integrated luminosity of 1 fb -1 devoted to the energy scan, a top quark mass of about 150 GeV can be determined with an accuracy of ∼0.3 GeV, with a comparable systematic uncertainty arising from the few % errors in the α s measurement at LEP-I. The possibilities of studying Γ t and Higgs boson effects are also discussed. 10 refs., 12 figs., 4 tabs

  10. The melting curve of iron to 250 gigapascals - A constraint on the temperature at earth's center

    Science.gov (United States)

    Williams, Quentin; Jeanloz, Raymond; Bass, Jay; Svendsen, Bob; Ahrens, Thomas J.

    1987-01-01

    The melting curve of iron, the primary constituent of earth's core, has been measured to pressures of 250 gigapascals with a combination of static and dynamic techniques. The melting temperature of iron at the pressure of the core-mantle boundary (136 GPa) is 4800 + or - 200 K, whereas at the inner core-outer core boundary (330 GPa), it is 7600 + or - 500 K. A melting temperature for iron-rich alloy of 6600 K at the inner core-outer core boundary and a maximum temperature of 6900 K at earth's center are inferred. This latter value is the first experimental upper bound on the temperature at earth's center, and these results imply that the temperature of the lower mantle is significantly less than that of the outer core.

  11. On artefact-free reconstruction of low-energy (30–250 eV) electron holograms

    Energy Technology Data Exchange (ETDEWEB)

    Latychevskaia, Tatiana, E-mail: tatiana@physik.uzh.ch; Longchamp, Jean-Nicolas; Escher, Conrad; Fink, Hans-Werner

    2014-10-15

    Low-energy electrons (30–250 eV) have been successfully employed for imaging individual biomolecules. The most simple and elegant design of a low-energy electron microscope for imaging biomolecules is a lensless setup that operates in the holographic mode. In this work we address the problem associated with the reconstruction from the recorded holograms. We discuss the twin image problem intrinsic to inline holography and the problem of the so-called biprism-like effect specific to low-energy electrons. We demonstrate how the presence of the biprism-like effect can be efficiently identified and circumvented. The presented sideband filtering reconstruction method eliminates the twin image and allows for reconstruction despite the biprism-like effect, which we demonstrate on both, simulated and experimental examples. - Highlights: • Radiation damage-free imaging of individual biomolecules. • Elimination of the twin image in inline holograms. • Circumventing biprism-like effect in low-energy electron holograms. • Artefact-free reconstructions of low-energy electron holograms.

  12. On artefact-free reconstruction of low-energy (30–250 eV) electron holograms

    International Nuclear Information System (INIS)

    Latychevskaia, Tatiana; Longchamp, Jean-Nicolas; Escher, Conrad; Fink, Hans-Werner

    2014-01-01

    Low-energy electrons (30–250 eV) have been successfully employed for imaging individual biomolecules. The most simple and elegant design of a low-energy electron microscope for imaging biomolecules is a lensless setup that operates in the holographic mode. In this work we address the problem associated with the reconstruction from the recorded holograms. We discuss the twin image problem intrinsic to inline holography and the problem of the so-called biprism-like effect specific to low-energy electrons. We demonstrate how the presence of the biprism-like effect can be efficiently identified and circumvented. The presented sideband filtering reconstruction method eliminates the twin image and allows for reconstruction despite the biprism-like effect, which we demonstrate on both, simulated and experimental examples. - Highlights: • Radiation damage-free imaging of individual biomolecules. • Elimination of the twin image in inline holograms. • Circumventing biprism-like effect in low-energy electron holograms. • Artefact-free reconstructions of low-energy electron holograms

  13. The G-250A polymorphism in the hepatic lipase gene promoter is associated with changes in hepatic lipase activity and LDL cholesterol: The KANWU Study

    DEFF Research Database (Denmark)

    Lindi, Virpi; Schwab, Ursula; Louheranta, Anne

    2007-01-01

    BACKGROUND AND AIMS: Hepatic lipase (HL) catalyzes the hydrolysis of triglycerides and phospholipids from lipoproteins, and promotes the hepatic uptake of lipoproteins. A common G-250A polymorphism in the promoter of the hepatic lipase gene (LIPC) has been described. The aim was to study...

  14. Customized broadband sloan-filters for the JST/T250 and JAST/T80 telescopes: summary of results

    Science.gov (United States)

    Brauneck, U.; Sprengard, R.; Bourquin, S.; Marín-Franch, A.

    2017-09-01

    The Centro de Estudios de Fisica del Cosmos de Aragon (CEFCA) will conduct a photometric sky survey with 2 new telescopes recently setup on the Javalambre mountain in Spain: the JST/T250 is a 2.55m telescope with a plate scale of 22.67"/mm and a 3° diameter field of view (FoV) and the auxiliary telescope JAST/T80 with a 82cm primary mirror and a FoV of 2 deg diameter. A multiple CCD (9k-by-9k array size, 10μm pixel size) mosaic camera is used in combination with filter trays or filter wheels, each containing a multitude of filters in dimensions of 101.7x96.5mm or 106.8x106.8mm. For this project, SCHOTT manufactured 56 specially designed narrow band steep edged bandpass interference filters and 5 broadband sloan-filters which were completed only recently. We report here on the results of the broadband sloanfilters with transmission bands of 324-400nm (sloan-u), 400-550nm (sloan-g), 550-700nm (sloan-r), 695-850nm (sloan-i) and 830-1200nm (sloan-z). The filters are composed of SCHOTT filterglasses and clearglass substrates coated with interference filters and represent an improvement of broadband sloan filters commonly used in astronomy. Inspite of the absorptive elements, the filters show maximum possible transmissions achieved by magnetron sputtered filter coatings. In addition the blocking of the filters is better than OD5 in the range 250-1050nm. A high image quality required a low transmitted wavefront error (<λ/8 locally, respectively <λ/2 globally) which was achieved by combining up to 2 substrates. We report on the spectral and interferometric results measured on the filters.

  15. A spectroscopic study of uranyl speciation in chloride-bearing solutions at temperatures up to 250 °C

    Science.gov (United States)

    Migdisov, A. A.; Boukhalfa, H.; Timofeev, A.; Runde, W.; Roback, R.; Williams-Jones, A. E.

    2018-02-01

    The speciation of U in NaCl-bearing solutions at temperatures up to 250 °C and concentrations of NaCl up to 1.5 m has been investigated using an in situ spectroscopic technique. The recorded spectra permit us to identify the species present in the solutions as UO22+, UO2Cl+, and UO2Cl2°. UO2Cl3- is also likely present at high temperatures and NaCl concentrations, but concentrations of this species are insufficient for derivation of the formation constants. No evidence was found for species of higher ligand (Cl-) number. Thermodynamic stability constants derived for these species show fair agreement with published data for 25 °C, but differ significantly from those predicted by an earlier high-temperature study (Dargent et al., 2013), which suggested that UO2Cl42- and UO2Cl53- contribute significantly to the mass balance of uranyl chloride complexes, especially at high temperature. In contrast, our data suggest that the main uranyl-chloride complex present in aqueous solutions at T > 150 °C and concentrations of NaCl relevant to natural hydrothermal systems is UO2Cl2°. The values of the logarithms of thermodynamic formation constants (β) for the reaction UO22+ + Cl- = UO2Cl+ are 0.02, 0.25, 0.55, 1.09, 1.59, and 2.28 derived at 25, 50, 100, 150, 200, and 250 °C, respectively. For the reaction UO22+ + 2Cl- = UO2Cl2° the values of log β derived at these temperatures are 0.4, 0.58, 0.74, 1.44, 2.18, and 3.42. Values of the formation constant estimated for uranyl-chloride species predict the high concentrations of U observed by Richard et al. (2011) in fluid inclusions of the giant McArthur River unconformity-type uranium deposit.

  16. Straight and chopped DC performance data for a reliance EV-250AT motor with a General Electric EV-1 controller

    Science.gov (United States)

    Edie, P. C.

    1981-01-01

    Straight and chopped DC motor performances for a Reliance EV-250AT motor with an EV-1 controller were examined. Effects of motor temperature and operating voltage are shown. It is found that the maximum motor efficiency is approximately 85% at low operating temperatures in the straight DC mode. Chopper efficiency is 95% under all operating conditions. For equal speeds, the motor operated in the chopped mode develops slightly more torque and draws more current than it does in the straight DC mode.

  17. Desarrollo tecnológico de la formulación de cápsulas de ampicilina 250 y 500 mg

    Directory of Open Access Journals (Sweden)

    María Antonia Serrate

    1997-08-01

    Full Text Available Se describió el desarrollo tecnológico para la formulación de cápsulas de ampicilina trihidratada, reutilizando los finos que se obtienen de la tecnología por vía seca y que representan el 30 % de ésta. Se utilizó la vía húmeda por las características del fino obtenido y se logró un producto actualizado y con las características adecuadas para su uso. Las cápsulas de 250 y 500 mg fueron sometidas a estudio de estabilidad a temperaturas controladas y se determinaron las características físicoquímicas que debe cumplir el granulado. Esta reutilización de los finos, producto de la vía seca, logra un aprovechamiento óptimo de la materia prima que se dedica a esta producción.The technological development to produce the formulation of capsules of ampicillin trihydrate using again the products obtained through the dry procedure representing the 30 % of it, is described. A wet procedure was used because of the characteristics of the powder obtained and a current product was obtained having the proper characteristics for its use. Capsules of 250 and 500 mg were subjected to stability studies at controlled temperature and the physical and chemical characteristics that may comply with the granulate were also determined. This reutilization of fine products through the dry procedure makes it possible to attain an optimun use of the raw material employed for this production.

  18. Alzheimer's disease presenilin-1 exon 9 deletion and L250S mutations sensitize SH-SY5Y neuroblastoma cells to hyperosmotic stress-induced apoptosis

    DEFF Research Database (Denmark)

    Tanii, H; Ankarcrona, M; Flood, F

    2000-01-01

    . In the present study, we determined whether PS1 mutations also sensitize cells to hyperosmotic stress-induced apoptosis. For this, we established SH-SY5Y neuroblastoma cell lines stably transfected with wild-type PS1 or either the PS1 exon 9 deletion (deltaE9) or PS1 L250S mutants. Cultured cells were exposed...

  19. Isolation of a 250 million-year-old halotolerant bacterium from a primary salt crystal

    Science.gov (United States)

    Vreeland, Russell H.; Rosenzweig, William D.; Powers, Dennis W.

    2000-10-01

    Bacteria have been found associated with a variety of ancient samples, however few studies are generally accepted due to questions about sample quality and contamination. When Cano and Borucki isolated a strain of Bacillus sphaericus from an extinct bee trapped in 25-30 million-year-old amber, careful sample selection and stringent sterilization techniques were the keys to acceptance. Here we report the isolation and growth of a previously unrecognized spore-forming bacterium (Bacillus species, designated 2-9-3) from a brine inclusion within a 250million-year-old salt crystal from the Permian Salado Formation. Complete gene sequences of the 16S ribosomal DNA show that the organism is part of the lineage of Bacillus marismortui and Virgibacillus pantothenticus. Delicate crystal structures and sedimentary features indicate the salt has not recrystallized since formation. Samples were rejected if brine inclusions showed physical signs of possible contamination. Surfaces of salt crystal samples were sterilized with strong alkali and acid before extracting brines from inclusions. Sterilization procedures reduce the probability of contamination to less than 1 in 10 9.

  20. Utilization of a typical 250 kW TRIGA Mark II reactor at a University

    International Nuclear Information System (INIS)

    Villa, M.; Boeck, H.; Musilek, A.

    2007-01-01

    The 250 kW TRIGA Mark-II reactor operates since March 1962 at the Atominstitut Vienna/Austria. Its main tasks are nuclear education and training in the fields of neutron- and solid state physics, nuclear technology, reactor safety, radiochemistry, radiation protection and dosimetry, and low temperature physics and fusion research. Academic research is carried out by students in the above mentioned fields coordinated and supervised by about 70 staff members with the aim of a masters- or PhD degree in one of the above mentioned areas. During the past 15 years about 580 students graduated through the Atominstitut. In addition, the Atominstitut co-operates closely with the nearby located IAEA in research projects, coordinated research programs (CRP) and supplying expert services. Regular training courses are carried out for the IAEA for Safeguard Trainees, fellowship places are offered for scientists from developing countries and staff members carry out expert missions to research centres in Africa, Asia and South America. Special Nuclear Material (SNM) is stored for calibration purposes at the Atominstitut belonging to the IAEA. (author)

  1. The 250AH/90A active lithium-thionyl chloride cell for Centaur-G application

    Science.gov (United States)

    Zolla, A. E.; Tura, D. D.

    1987-09-01

    A high rate active Li/SOCl2 cell was designed for use in a 28 volt, 250 amp-hour space battery system. The lithium battery is being considered as a replacement of its heavier silver-zinc counterpart on board the Centaur-G booster rocket which is used to launch payloads from the Space Shuttle cargo bay into deep-space. Basically a feasibility study, this development effort is demonstrating the ability of the lithium cell to deliver up to 90 amps safely at power densities of approximately 25 watts per pound. Test data on 4 prototype units is showing an energy density of 85 watt-hours per pound and 9.0 watt-hours/cu in. The cells tested typically delivered 280 to 300 amp-hours under ambient temperature test conditions using alternating continuous loads of 90, 55, and 20 amperes throughout life. Data from four cells tested are presented to demonstrate the capability of Li/SOCl2 technology for a C/3 discharge rate in active and hermetic cell units.

  2. Difference in Injury Mode, Dose-Rate Dependence and RBE of 730-Mev Protons, 100-KVp X-Rays and 250-KVp X-Rays; Differences dans le Type de Lesion, l'Importance du Debit de Dose et l'EBR entre les Protons de 730 Mev, les Rayons X de 100 Kv-Crete et les Rayons X de 250 Kv-Crete; Razlichiya kharaktera porazheniya, zavisimosti ot moshchnosti dozy i obeh protonov s ehnergiej 730 mehv i rentgenovskikh luchej s pikovym napryazheniem 100 i 250 kv; Diferencias en la Modalidad de La Lesion, la Relacion con la Intensidad de Dosis y la EBR de los Protones de 730 Mev, y los Rayos X de 100 Kvp Y de 250 Kvp

    Energy Technology Data Exchange (ETDEWEB)

    Sondhaus, C. A.; Wallace, R. W.; Lyman, J. T.; Kase, K. W.; Steward, P. G. [University of California Lawrence Radiation Laboratory Berkeley (United States)

    1964-03-15

    Mortality at 6 , 12, and 30 d was studied in male Swiss-Webster white mice exposed to 730-MeV protons, 250-kVp X-rays, and 100-kVp X-rays at different dose rates. In the proton irradiated mice, 6 - to 8 -d gastro-intestinal death predominated at both 100 and 1000 rad/min, and was enhanced at the higher dose rate. In the X-ray exposures, 12- to 14-d haematopoietic death predominated and showed a similar dose-rate effect. The RBE of protons relative to 250 kVp X-ray for 30-d LD{sub 50} was found to be 0.8 ; the RBE for 6-d LD{sub 50} was found to be 1.2 at the same dose rate of 100 rad/min. It is suggested that the difference in injury mode may be due to differences in tissue dose distribution. The higher but variable proton RBE for 6 -d gut death appears to exhibit the dose-rate effect associated with low-LET exposure. Practical consequences of the dose distribution and dose-rate factois are discussed. (author) [French] Ils auteurs ont etudie la mortalite apres 6 , 10 et 30 j chez des souris blanches males Swiss Webster exposees a des protons de 730 MeV, a des rayons X de 250 kV-crete et a des rayons X de 100 kV-crete, avec des debits de dose differents. Chez les souris exposees aux protons, on a observe une predominance de la mortalite apres 6 a 8 j due au syndrome gastro-intestinal, a 100 et 1000 rad/min; la mortalite etait plus elevee a 1000 rad/min. Chez les souris exposees aux rayons X , on a observe une predominance de la mortalite apres 12 a 14 j due au syndrome hematopoletique, avec effet similaire du debit de dose. L'EBR des protons par rapport aux rayons X de 250 kV-crete pour la DL{sup 30}{sub 50} etait de 0,8 et l'EBR pour la DL{sup 6}{sub 50} etait de 1,2 pour un meme debit de dose de 100 rad/min. La difference dans les types de lesions peut etre due a des differences de distribution de la dose dans les tissus. L'EBR des protons, plus elevee mais variable, pour la mortalite apres six jours causee par des lesions de l'appareil digestif semble reveler le

  3. Thermal analysis of a conceptual design for a 250 W(e) GPHS/FPSE space power system

    International Nuclear Information System (INIS)

    Mccomas, T.J.; Dugan, E.T.

    1991-01-01

    A thermal analysis has been performed for a 250-W(e) space nuclear power system which combines the US Department of Energy's general purpose heat source (GPHS) modules with a state-of-the-art free-piston Stirling engine (FPSE). The focus of the analysis is on the temperature of the indium fuel clad within the GPHS modules. The thermal analysis results indicate fuel clad temperatures slightly higher than the design goal temperature of 1573 K. The results are considered favorable due to numerous conservative assumptions used. To demonstrate the effects of the conservatism, a brief sensitivity analysis is performed in which a few of the key system parameters are varied to determine their effect on the fuel clad temperatures. It is shown that thermal analysis of a more detailed thermal mode should yield fuel clad temperatures below 1573 K. 3 refs

  4. About 250 cases of skeletal scintiscanning using sup(99m)Tc-labelled stannous pyrophosphate. Analytical and critical study

    International Nuclear Information System (INIS)

    Suss, Leopold.

    1975-01-01

    The physical and biological characteristics of 85 Sr, 87 Sr, 18 F and sup(99m)Tc, four radionuclides suitable for skeletal imaging are reviewed. Their mechanism of localization, advantages and disadvantages are described. The physical characteristics and relative tissue concentration of sup(99m)Tc compare favorably to those of the other bone-seeking radionuclides. 250 cases of various skeletal diseases are presented, using sup(99m)Tc-pyrophosphate as a skeletal imaging agent. This radiopharmaceutical proves to be useful particularly in the detection of bone metastases. Bone scans, however, are not 100% positive with metastatic diseases and false negative do occasionally occur. The scan is also helpful in demonstrating the extent of metastatic bone disease [fr

  5. A reflectivity profilometer for the optical characterisation of grade reflectivity mirrors in the 250 nm - 1100 nm spectral region

    Energy Technology Data Exchange (ETDEWEB)

    Colucci, Alessandro; Nichelatti, Enrico [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dipt. Innovazione

    1998-04-01

    It`s developed the prototype of an instrument that can be used for the optical characterisation of graded reflectivity mirrors at any wavelength in the spectral region from 250 nm to 1100 nm. The instrument utilises a high-pressure Xe arc lamp as light source. Light is spectrally filtered by means of a grating monochromator. The sample is illuminated with an image of the monochromator exit slit. After reflection from the sample, this image is projected onto a 1024-elements charge-coupled device linear array driven by a digital frame board and interfaced with a personal computer. It`s tested the instrument accuracy by comparing measurement results with the corresponding ones obtained by means of a laser scanning technique. Measurement Rms repeatability has been estimated to be approximately of 0.8%. [Italiano] E` stato sviluppato il prototipo di uno strumento per la catatterizzazione ottica di specchi a riflettivita` variabile, operante a qualsiasi lunghezza d`onda nell`intervallo spettrale da 250 nm a 1100 nm. La sorgente dello strumento e` una lampada ad arco allo Xenon ad alta pressione. La luce e` filtrata spettralmente per mezzo di un monocromatore a reticolo. Il campione viene illuminato da un`immagine della fenditura d`uscita del monocromatore. Dopo essere stata riflessa dal campione, questa immagine viene proiettata su un array CCD lineare a 1024 elementi, connesso elettronicamente a una scheda digitale e interfacciato a un personal computer. L`accuratezza dello strumento e` stata verificata confrontando alcune misure con le corrispondenti misure ottenute mediante una tecnica a scansione laser. La ripetibilita` RMS delle misure e` stata stimata essere circa dello 0.8%.

  6. Buckling measurements up to 250 deg C on lattices of Agesta clusters and on D2O alone in the pressurized exponential assembly TZ

    International Nuclear Information System (INIS)

    Persson, R.; Andersson, A.J.W.; Wikdahl, C.E.

    1966-11-01

    Buckling determinations by means of flux mapping were performed in TZ up to 250 deg C on two lattices of Aagesta fuel assemblies in D 2 O and on D 2 O alone. Most of the flux measurements were made with fission counters in pressure thimbles. The perturbations caused by the thimbles were studied experimentally in various ways and compared with two group diffusion-theory calculations. In one of the lattices the effectiveness of a control rod (AglnCd) was also investigated. The results of the diffusion length experiments indicated some systematic error of the order of 0.15 - 0.10/m 2 in the bucklings measured, though the temperature dependence should be well established. The bucklings of the two lattices studied (square pitches 24 and 27 cm) were found to be less sensitive to temperature than theoretical calculations predict, the temperature coefficient being more than 10 per cent smaller. The buckling changes from 20 to 250 deg C were about -2.4 and -1.8/m 2 , respectively, for the two lattices. During part of the experimental period we had, for some unexplained reason, about 30 per cent excess absorption in the heavy water

  7. Photodegradation of 17α-ethynylestradiol in aqueous solution exposed to a high-pressure mercury lamp (250 W)

    International Nuclear Information System (INIS)

    Liu, X.L.; Wu, F.; Deng, N.S.

    2003-01-01

    The photodegradation of 17α-ethynylestradiol (EE 2 ) induced by high-pressure mercury lamp (λ≥313, 250 W) in aqueous solution of EE 2 was investigated initially. The affecting factors on the photodegradation were studied and described in details, such as EE 2 initial concentration, Fe 3+ , algae, exposure time, and so on. The concentration of EE 2 in distilled water was mainly determined using fluorescence spectrophotometer. The photodegradation of EE 2 in aqueous solution exposed to high-pressure mercury lamp was evident and could be accelerated by Fe 3+ or algae (e.g. Anabaena cylindrica) in general. With the algae concentration increasing, photodegradation rate increased. In this paper, the mechanism of photocatalytic degradation of EE 2 by Fe 3+ or algae is discussed primarily. - Photodegradation increased with increasing concentrations of algae

  8. On-chip measurements of Brownian relaxation of magnetic beads with diameters from 10 nm to 250 nm

    DEFF Research Database (Denmark)

    Østerberg, Frederik Westergaard; Rizzi, Giovanni; Hansen, Mikkel Fougt

    2013-01-01

    We demonstrate the use of planar Hall effect magnetoresistive sensors for AC susceptibility measurements of magnetic beads with frequencies ranging from DC to 1 MHz. This wide frequency range allows for measuring Brownian relaxation of magnetic beads with diameters ranging from 10 nm to 250 nm....... Brownian relaxation is measured for six different magnetic bead types and their hydrodynamic diameters are determined. The hydrodynamic diameters are found to be within 40% of the nominal bead diameters. We discuss the applicability of the different bead types for volume-based biosensing with respect...... to sedimentation, magnetic trapping, and signal per bead. Among the investigated beads, we conclude that the beads with a nominal diameter of 80 nm are best suited for future on-chip volume-based biosensing experiments using planar Hall effect sensors....

  9. Effect of a 5000 ppm fluoride toothpaste and a 250 ppm fluoride mouth rinse on the demineralisation of dentin surfaces.

    Science.gov (United States)

    Bizhang, Mozhgan; Chun, Yong-Hee P; Winterfeld, Mai-Trinh; Altenburger, Markus J; Raab, Wolfgang H M; Zimmer, Stefan

    2009-07-23

    The purpose of this study was to test the null hypothesis that there is no difference between the effect of (1) a 5000 ppm fluoride toothpaste, and (2) a 250 ppm fluoride mouth rinse on demineralized human dentin surfaces, against the alternative hypothesis of a difference. Dentin specimens were obtained from the cervical regions of 45 extracted human third molars. Half the surface of each specimen was sealed with a self-etching adhesive system and served as the reference surface. The dentin specimens were randomly assigned to one of the three groups, 5000 ppm fluoride toothpaste (Duraphat), 250 ppm fluoride mouth rinse (Meridol) and distilled water (negative control).An intraoral appliance was made for one volunteer. In each test cycle, 15 specimens were inserted in the appliance and worn for 24 hours a day, over a period of three weeks.Once daily, the appliance was immersed in the agent being tested; either toothpaste slurry, mouth rinse or distilled water for 60 seconds.Demineralization was assessed in terms of lesion depth (microm) and mineral loss (vol. % x microm) by transversal microradiography. Data analysis was accomplished using Kolmogorov-Smirnov test and ANOVA (SPSS 12.0).Statistically significant differences for mineral loss and lesion depth were found between the toothpaste and the mouth rinse as well as between the toothpaste and the control group, but not between the mouth rinse and the control group. Within the limitations of this study, the results suggest that treatment of demineralised dentin with a toothpaste containing 5000 ppm fluoride may considerably reduce mineral loss and lesion depth on exposed dentin.

  10. Low cycle fatigue behaviour of neutron irradiated copper alloys at 250 and 350 deg. C. (ITER R and D Task no. T213)

    International Nuclear Information System (INIS)

    Singh, B.N.; Stubbins, J.F.; Toft, P.

    2000-03-01

    The fatigue behaviour of a dispersion strengthened and a precipitation hardened copper alloys was investigated with and without irradiation exposure. Fatigue specimens of these alloys were irradiated with fission neutrons in the DR-3 reactor at Risoe with a flux of ∼2.5 x 10 17 n/m 2 s (E> 1 MeV) to influence levels of 1.0 - 1.5 x 10 24 n/m 2 (E> 1 MeV) at 250 and 350 deg. C. These irradiations were carried out in temperature controlled rigs where the irradiation temperature was monitored and controlled continuously throughout the whole irradiation experiment. Both unirradiated and irradiated specimens were fatigue tested in vacuum at the irradiation temperatures of 250 and 350 deg. C in a strain controlled mode with a loading frequency of 0.5Hz. Post-fatigue microstructures were examined using transmission electron microscopy and the fracture surfaces were investigated using scanning electron microscope. The present investigations demonstrated that the fatigue life decreases with increasing temperature and that the exposure to neutron irradiation causes further degradation in fatigue life at both temperatures. These results are discussed in terms of the observed post-fatigue microstructures and the fracture surface morphology. Finally, the main conclusions and their implications are summarised. (au)

  11. Atomic Mass Dependence of $\\Xi^{-}$ Baryon and $\\bar \\Xi^+$ Baryon Production in Central 250-GeV/c $\\pi^-$ - Nucleon Interactions

    Energy Technology Data Exchange (ETDEWEB)

    Dagenhart, William David [Tufts U.

    2000-02-01

    We present the first measurement of the atomic mass dependence of central $\\Xi^-$ and $\\overline{\\Xi}^+$ production. It is measured using a sample of 22,459 $\\Xi^-$'s and $\\overline{\\Xi}^+$'s produced in collisions between a 250 GeV/c $\\pi^-$ beam and targets of beryllium, aluminum, copper, and tungsten. The relative cross sections are fit to the two parameter function $\\sigma_0 A^{\\alpha}$, where A is the atomic mass. We measure $\\alpha$ = 0:924 $\\pm$ 0:020 $\\pm$ 0:025, for Feynman-x in the range $\\pm$ 0:09 < $x_F$ < 0:15.

  12. High Resolution PET with 250 micrometer LSO Detectors and Adaptive Zoom

    International Nuclear Information System (INIS)

    Cherry, Simon R.; Qi, Jinyi

    2012-01-01

    There have been impressive improvements in the performance of small-animal positron emission tomography (PET) systems since their first development in the mid 1990s, both in terms of spatial resolution and sensitivity, which have directly contributed to the increasing adoption of this technology for a wide range of biomedical applications. Nonetheless, current systems still are largely dominated by the size of the scintillator elements used in the detector. Our research predicts that developing scintillator arrays with an element size of 250 (micro)m or smaller will lead to an image resolution of 500 (micro)m when using 18F- or 64Cu-labeled radiotracers, giving a factor of 4-8 improvement in volumetric resolution over the highest resolution research systems currently in existence. This proposal had two main objectives: (i) To develop and evaluate much higher resolution and efficiency scintillator arrays that can be used in the future as the basis for detectors in a small-animal PET scanner where the spatial resolution is dominated by decay and interaction physics rather than detector size. (ii) To optimize one such high resolution, high sensitivity detector and adaptively integrate it into the existing microPET II small animal PET scanner as a 'zoom-in' detector that provides higher spatial resolution and sensitivity in a limited region close to the detector face. The knowledge gained from this project will provide valuable information for building future PET systems with a complete ring of very high-resolution detector arrays and also lay the foundations for utilizing high-resolution detectors in combination with existing PET systems for localized high-resolution imaging.

  13. SU-F-T-146: Comparing Monte Carlo Simulations with Commissioning Beam Data for Mevion S250 Proton Therapy System

    Energy Technology Data Exchange (ETDEWEB)

    Prusator, M; Jin, H; Ahmad, S; Chen, Y [University of Oklahoma Health Sciences Center, Oklahoma City, OK (United States)

    2016-06-15

    Purpose: To evaluate the Monte Carlo simulated beam data with the measured commissioning data for the Mevion S250 proton therapy system. Method: The Mevion S250 proton therapy system utilizes a passive double scattering technique with a unique gantry mounted superconducting accelerator and offers effective proton therapy in a compact design concept. The field shaping system (FSS) includes first scattering foil, range modulator wheel (RMW), second scattering foil and post absorber and offers two field sizes and a total of 24 treatment options from proton range of 5 cm to 32 cm. The treatment nozzle was modeled in detail using TOPAS (TOolkit for PArticle Simulation) Monte Carlo code. The timing feathers of the moving modulator wheels were also implemented to generate the Spread Out Bragg Peak (SOBP). The simulation results including pristine Bragg Peak, SOBP and dose profiles were compared with the data measured during beam commissioning. Results: The comparison between the measured data and the simulation data show excellent agreement. For pristine proton Bragg Peaks, the simulated proton range (depth of distal 90%) values agreed well with the measured range values within 1 mm accuracy. The differences of the distal falloffs (depth from distal 80% to 20%) were also found to be less than 1 mm between the simulations and measurements. For the SOBP, the widths of modulation (depth of proximal 95% to distal 90%) were also found to agree with the measurement within 1 mm. The flatness of the simulated and measured lateral profiles was found to be 0.6 % and 1.1 %, respectively. Conclusion: The agreement between simulations and measurements demonstrate that TOPAS could be used as a viable platform to proton therapy applications. The matched simulation results offer a great tool and open opportunity for variety of applications.

  14. Early phyllosilicates formed by alteration of R7T7 glass in water at 250 deg C

    International Nuclear Information System (INIS)

    Vernaz, E.; Dussossoy, J.L.; Caurel, J.; Crovisier, J.L.

    1991-01-01

    T7T7 glass samples have been altered during periods of one and seven days at 250 deg C in distilled water. Ultramicrotomic thin sections were performed in the outermost part of the glass for a study under analytical transmission electron microscope. After one day the alteration layer is about 5 μm thick. It is made up of sheeted silicated particles, tentatively identified as septechlorite (7 A intervals) mixed with an intercrystalline amorphous matrix of different composition. After seven days the alteration layer is about 11 μm thick. It is made up of sheeted silicated particles of smectite type (10 A intervals). No 7 A particles were found in the seven days sample. This study illustrates the capacity of poorly crystalline phyllosilicates to adapt to the chemical changes in solution. 15 refs., 4 tabs., 2 plates

  15. Buckling measurements up to 250 deg C on lattices of Agesta clusters and on D{sub 2}O alone in the pressurized exponential assembly TZ

    Energy Technology Data Exchange (ETDEWEB)

    Persson, R; Andersson, A J.W.; Wikdahl, C E

    1966-11-15

    Buckling determinations by means of flux mapping were performed in TZ up to 250 deg C on two lattices of Aagesta fuel assemblies in D{sub 2}O and on D{sub 2}O alone. Most of the flux measurements were made with fission counters in pressure thimbles. The perturbations caused by the thimbles were studied experimentally in various ways and compared with two group diffusion-theory calculations. In one of the lattices the effectiveness of a control rod (AglnCd) was also investigated. The results of the diffusion length experiments indicated some systematic error of the order of 0.15 - 0.10/m{sup 2} in the bucklings measured, though the temperature dependence should be well established. The bucklings of the two lattices studied (square pitches 24 and 27 cm) were found to be less sensitive to temperature than theoretical calculations predict, the temperature coefficient being more than 10 per cent smaller. The buckling changes from 20 to 250 deg C were about -2.4 and -1.8/m{sup 2}, respectively, for the two lattices. During part of the experimental period we had, for some unexplained reason, about 30 per cent excess absorption in the heavy water.

  16. Search for Σc → Λcπ using Λc → Σsππ in 250 GeV π--nucleon interactions

    International Nuclear Information System (INIS)

    Passmore, D.A.

    1995-01-01

    Combined cross section times branching fraction limits are given for Σ c ++ → Λ c + π + and Σ c 0 → Λ c + π - where Λ c + → Σ s ± π ± π + . The Λ c + is reconstructed with partial information on the Σ s ; the missing Σ s momentum is established through momentum conservation imposed by a constrained fit. The data are of π - beam interactions at 250 GeV from Fermilab experiment E769

  17. TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution

    DEFF Research Database (Denmark)

    Samuelsen, Camilla O; Baraznenok, Vera; Khorosjutina, Olga

    2003-01-01

    In Saccharomyces cerevisiae Mediator, a subgroup of proteins (Srb8, Srb9, Srb10, and Srb11) form a module, which is involved in negative regulation of transcription. Homologues of Srb10 and Srb11 are found in some mammalian Mediator preparations, whereas no clear homologues have been reported...... for Srb8 and Srb9. Here, we identify a TRAP240/ARC250 homologue in Schizosaccharomyces pombe and demonstrate that this protein, spTrap240, is stably associated with a larger form of Mediator, which also contains conserved homologues of Srb8, Srb10, and Srb11. We find that spTrap240 and Sch. pombe Srb8 (sp......Srb8) regulate the same distinct subset of genes and have indistinguishable phenotypic characteristics. Importantly, Mediator containing the spSrb8/spTrap240/spSrb10/spSrb11 subunits is isolated only in free form, devoid of RNA polymerase II. In contrast, Mediator lacking this module associates...

  18. Construction and start-up of a 250 kW natural gas fueled MCFC demonstration power plant

    Energy Technology Data Exchange (ETDEWEB)

    Figueroa, R.A.; Carter, J.; Rivera, R.; Otahal, J. [San Diego Gas & Electric, CA (United States)] [and others

    1996-12-31

    San Diego Gas & Electric (SDG&E) is participating with M-C Power in the development and commercialization program of their internally manifolded heat exchanger (IMHEX{reg_sign}) carbonate fuel cell technology. Development of the IMHEX technology base on the UNOCAL test facility resulted in the demonstration of a 250 kW thermally integrated power plant located at the Naval Air Station at Miramar, California. The members of the commercialization team lead by M-C Power (MCP) include Bechtel Corporation, Stewart & Stevenson Services, Inc., and Ishikawajima-Harima Heavy Industries (IHI). MCP produced the fuel cell stack, Bechtel was responsible for the process engineering including the control system, Stewart & Stevenson was responsible for packaging the process equipment in a skid (pumps, desulfurizer, gas heater, turbo, heat exchanger and stem generator), IHI produced a compact flat plate catalytic reformer operating on natural gas, and SDG&E assumed responsibility for plant construction, start-up and operation of the plant.

  19. Study of SiO2 surface sputtering by a 250-550 keV He+ ion beam during high-resolution Rutherford backscattering measurements

    International Nuclear Information System (INIS)

    Kusanagi, Susumu; Kobayashi, Hajime

    2006-01-01

    Decreases in oxygen signal intensities in spectra of high-resolution Rutherford backscattering spectrometry (HRBS) were observed during measurements on a 5-nm thick SiO 2 layer on a Si substrate when irradiated by 250-550 keV He + ions. Shifts in an implanted arsenic profile in a 5-nm thick SiO 2 /Si substrate were also observed as a result of He + ion irradiation. These results lead to the conclusion that the SiO 2 surface was sputtered by He + ions in this energy range

  20. Effect of chloride and sulphate ions on the electrochemical corrosion behavior of alloy 800NG in PWR secondary water environment at 250 deg C

    International Nuclear Information System (INIS)

    Mansur, Fabio A.; Schvartzman, Monica Maria de A.M.; Quinan, Marco A.D.; Soares, Antonio E.G.; Nogueira, Pedro Henrique B.O.

    2013-01-01

    Alloy 800NG (nuclear grade) is used in nuclear steam generators (SG) as the tubing material for pressurized water reactors (PWRs) because of its high corrosion resistance. The corrosion resistance is due to the protective character of the oxide film formed on the tube surface by contact with the high temperature pressurized water. Nevertheless, corrosion has been the major cause of tube failures in nuclear SGs. The existing experience of different nuclear power plants shows that the water chemistry has an important role in maintaining the integrity of the protective oxide films. Many of such problems have been attributed to secondary side water chemistry conditions and excursions, many of which have been resulted from condenser cooling water ingress. Alloy 800 is known to undergo passivity breakdown and pitting in the presence of chloride ions under oxidative water conditions. In this work the effect of chloride and sulphate ions at various concentrations on the corrosion behavior of Alloy 800 tube at 250 deg C was investigated using the potentiodynamic anodic polarization technique. An active-passive transition occurred at 250 deg C in all studied conditions and the oxide film grown on surface showed greater porosity and lower resistance to localised corrosion in all studied conditions. (author)

  1. Possibility of construction in Bulgaria of a fast neutron therapy center on the base of the U-250 isochronous cyclotron

    International Nuclear Information System (INIS)

    Angelov, V.A.; Enchevich, I.B.

    1985-01-01

    Development of oncological disease treatment by fast neutrons in the world practice is reviewed. Main radiobiological results, which point to peculiarities of neutron therapy in comparison with standard X-ray therapy are considered. Main requirements for devices to be met, used in fast neutron therapy, are enumerated. On the basis of it, the possibility of construction in Bulgaria a fast neutron therapy center using the U-250 multipurpose cyclotron has been made. The conclusion is made that the main parameters of a proton beam in combination with an isocentrical head as a fast neutron source will create the conditions for realization of high-efficiency neutron therapy

  2. Evidence for collective expansion in light-particle emission following Au+Au collisions at 100, 150 and 250 A·MeV

    Science.gov (United States)

    Poggi, G.; Pasquali, G.; Bini, M.; Maurenzig, P.; Olmi, A.; Taccetti, N.; Alard, J. P.; Amouroux, V.; Basrak, Z.; Bastid, N.; Belayev, I. M.; Berger, L.; Blaich, Th.; Boussange, S.; Buta, A.; Čaplar, R.; Cerruti, C.; Cindro, N.; Coffin, J. P.; Donà, R.; Dupieux, P.; Dželalija, M.; Erö, J.; Fan, Z. G.; Fintz, P.; Fodor, Z.; Fraysse, L.; Freifelder, R.; Frolov, S.; Gobbi, A.; Grigorian, Y.; Guillaume, G.; Herrmann, N.; Hildenbrand, K. D.; Hölbling, S.; Houari, A.; Jeong, S. C.; Jundt, F.; Kecskemeti, J.; Koncz, P.; Korchagin, Y.; Kotte, R.; Krämer, M.; Kuhn, C.; Ibnouzahir, M.; Legrand, I.; Lebedev, A.; Maguire, C.; Manko, V.; Mgebrishvili, G.; Mösner, J.; Moisa, D.; Montarou, G.; Montbel, I.; Morel, P.; Neubert, W.; Pelte, D.; Petrovici, M.; Rami, F.; Ramillien, V.; Reisdorf, W.; Sadchikov, A.; Schüll, D.; Seres, Z.; Sikora, B.; Simion, V.; Smolyankin, S.; Sodan, U.; The, K.; Tezkratt, R.; Trzaska, M.; Vasiliev, M. A.; Wagner, P.; Wessels, J. P.; Wienold, T.; Wilhelmi, Z.; Wohlfarth, D.; Zhilin, A. V.; Danielewicz, P.; FOPI Collaboration

    1995-02-01

    Light-particle emission from Au+Au collisions has been studied in the bombarding-energy range 100-250 A·MeV, using ΔE- ER telescopes in coincidence with the FOPI detector in its phase I configuration. Center-of-mass energy spectra have been measured for Z = 1,2 isotopes emitted in central collisions at CM polar angles between 60° and 90°. Evidence for a collective expansion is reported, on the basis of the mean kinetic energies of hydrogen isotopes. Comparison is presented with statistical calculations (WIX code). For CM kinetic energy spectra, fair agreement is found between data and a recently developed transport model.

  3. Evidence for collective expansion in light-particle emission following Au+Au collisions at 100, 150 and 250 A.MeV

    International Nuclear Information System (INIS)

    Poggi, G.; Pasquali, G.; Bini, M.

    1995-01-01

    Light-particle emission from Au+Au collisions has been studied in the bombarding-energy range 100-250A.MeV, using ΔE-E R telescopes in coincidence with the FOPI detector in its phase I configuration. Center-of-mass energy spectra have been measured for Z=1, 2 isotopes emitted in central collisions at CM polar angles between 60 circle and 90 circle . Evidence for a collective expansion is reported, on the basis of the mean kinetic energies of hydrogen isotopes. Comparison is presented with statistical calculations (WIX code). For CM kinetic energy spectra, fair agreement is found between data and a recently developed transport model. ((orig.))

  4. Hard x-ray contact microscopy with 250 nm spatial resolution using a LiF film detector and a tabletop microsource

    International Nuclear Information System (INIS)

    Almaviva, S.; Bonfigli, F.; Franzini, I.; Lai, A.; Montereali, R. M.; Pelliccia, D.; Cedola, A.; Lagomarsino, S.

    2006-01-01

    An innovative route for deep-submicrometer spatial resolution hard x-ray microscopy with tabletop x-ray source is proposed. A film of lithium fluoride (LiF) was used as imaging detector in contact mode. We present here the x-ray images recorded on LiF films of a Fresnel zone plate with submicrometer gold structures and of an onion cataphyll. The images were read with an optical confocal microscope in fluorescence mode. The measured spatial resolution was about 250 nm, i.e., close to the resolution limit of the confocal microscope. The advantages and drawbacks, and the possible improvements, of this route are discussed

  5. Phase Equilibria of the Ternary Sn-Pb-Co System at 250°C and Interfacial Reactions of Co with Sn-Pb Alloys

    Science.gov (United States)

    Wang, Chao-hong; Kuo, Chun-yi; Yang, Nian-cih

    2015-11-01

    The isothermal section of the ternary Sn-Pb-Co system at 250°C was experimentally determined through a series of the equilibrated Sn-Pb-Co alloys of various compositions. The equilibrium phases were identified on the basis of compositional analysis. For the Sn-Co intermetallic compounds (IMCs), CoSn3, CoSn2, CoSn and Co3Sn2, the Pb solubility was very limited. There exist five tie-triangle regions. The Co-Pb system involves one monotectic reaction, so the phase separation of liquid alloys near the Co-Pb side occurred prior to solidification. The immiscibility field was also determined. Additionally, interfacial reactions between Co and Sn-Pb alloys were conducted. The reaction phase for the Sn-48 at.%Pb and Sn-58 at.%Pb at 250°C was CoSn3 and CoSn2, respectively. Both of them were simultaneously formed in the Sn-53 at.%Pb/Co. The formed IMCs were closely associated to the phase equilibria relationship of the liquid-CoSn3-CoSn2 tie-triangle. Furthermore, with increasing temperatures, the phase formed in equilibrium with Sn-37 wt.%Pb was found to transit from CoSn3 to CoSn2 at 275°C. We propose a simple method of examining the phase transition temperature in the interfacial reactions to determine the boundaries of the liquid-CoSn3-CoSn2 tie-triangles at different temperatures.

  6. Change in land use in the Phoenix (1:250,000) Quadrangle, Arizona between 1970 and 1973: ERTS as an aid in a nationwide program for mapping general land use. [Phoenix Quadrangle, Arizona

    Science.gov (United States)

    Place, J. L.

    1974-01-01

    Changes in land use between 1970 and 1973 in the Phoenix (1:250,000 scale) Quadrangle in Arizona have been mapped using only the images from ERTS-1, tending to verify the utility of a standard land use classification system proposed for use with ERTS images. Types of changes detected have been: (1) new residential development of former cropland and rangeland; (2) new cropland from the desert; and (3) new reservoir fill-up. The seasonal changing of vegetation patterns in ERTS has complemented air photos in delimiting the boundaries of some land use types. ERTS images, in combination with other sources of information, can assist in mapping the generalized land use of the fifty states by the standard 1:250,000 quadrangles. Several states are already working cooperatively in this type of mapping.

  7. Production of DNA minicircles less than 250 base pairs through a novel concentrated DNA circularization assay enabling minicircle design with NF-κB inhibition activity

    Science.gov (United States)

    Thibault, Thomas; Degrouard, Jeril; Baril, Patrick; Pichon, Chantal; Midoux, Patrick

    2017-01-01

    Abstract Double-stranded DNA minicircles of less than 1000 bp in length have great interest in both fundamental research and therapeutic applications. Although minicircles have shown promising activity in gene therapy thanks to their good biostability and better intracellular trafficking, minicircles down to 250 bp in size have not yet been investigated from the test tube to the cell for lack of an efficient production method. Herein, we report a novel versatile plasmid-free method for the production of DNA minicircles comprising fewer than 250 bp. We designed a linear nicked DNA double-stranded oligonucleotide blunt-ended substrate for efficient minicircle production in a ligase-mediated and bending protein-assisted circularization reaction at high DNA concentration of 2 μM. This one pot multi-step reaction based-method yields hundreds of micrograms of minicircle with sequences of any base composition and position and containing or not a variety of site-specifically chemical modifications or physiological supercoiling. Biochemical and cellular studies were then conducted to design a 95 bp minicircle capable of binding in vitro two NF-κB transcription factors per minicircle and to efficiently inhibiting NF-κB-dependent transcriptional activity in human cells. Therefore, our production method could pave the way for the design of minicircles as new decoy nucleic acids. PMID:27899652

  8. Measurement of the Production Cross Section for the Charmed Baryon $\\Lambda_c$ in 250 GeV/c Pion-Nucleon Interactions

    Energy Technology Data Exchange (ETDEWEB)

    dos Reis, Alberto Correa [Rio de Janeiro, CBPF

    1992-04-01

    This work a presents a measurement of the total cross section for the charmed baryon $\\Lambda_c$ times the branching fraction of the mode $\\Lambda_c \\to pK\\bar{\\mu}$, for the kinematical region $x_F$ > O in $\\pi$-nucleus interactions at 250 GeV/c. This measurement is made with data from the experiment E769, collected during 1987/1988 at the FERMILAB Tagged Photon Laboratory. A segmented target of berillium, aluminum, copper and tungsten was used. Based on the A dependence measurement, made by E769, and on the available branching fractions, the total cross section per nucleon is calculated. The result is compared with other experiments and with some theoretical predictions inspired on QCD.

  9. A pathogenic S250F missense mutation results in a mouse model of mild aromatic l-amino acid decarboxylase (AADC) deficiency.

    Science.gov (United States)

    Caine, Charlotte; Shohat, Meytal; Kim, Jeong-Ki; Nakanishi, Koki; Homma, Shunichi; Mosharov, Eugene V; Monani, Umrao R

    2017-11-15

    Homozygous mutations in the aromatic l-amino acid decarboxylase (AADC) gene result in a severe depletion of its namesake protein, triggering a debilitating and often fatal form of infantile Parkinsonism known as AADC deficiency. AADC deficient patients fail to produce normal levels of the monoamine neurotransmitters dopamine and serotonin, and suffer a multi-systemic disorder characterized by movement abnormalities, developmental delay and autonomic dysfunction; an absolute loss of dopamine is generally considered incompatible with life. There is no optimal treatment for AADC deficiency and few truly good models in which to investigate disease mechanisms or develop and refine therapeutic strategies. In this study, we introduced a relatively frequently reported but mildly pathogenic S250F missense mutation into the murine Aadc gene. We show that mutants homozygous for the mutation are viable and express a stable but minimally active form of the AADC protein. Although the low enzymatic activity of the protein resulted in only modestly reduced concentrations of brain dopamine, serotonin levels were markedly diminished, and this perturbed behavior as well as autonomic function in mutant mice. Still, we found no evidence of morphologic abnormalities of the dopaminergic cells in mutant brains. The striatum as well as substantia nigra appeared normal and no loss of dopamine expressing cells in the latter was detected. We conclude that even minute levels of active AADC are sufficient to allow for substantial amounts of dopamine to be produced in model mice harboring the S250F mutation. Such mutants represent a novel, mild model of human AADC deficiency. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  10. Analysis of Suspended-Sediment Dynamics in Gulf of Mexico Estuaries Using MODIS/Terra 250-m Imagery

    Science.gov (United States)

    McCarthy, M. J.; Otis, D. B.; Muller-Karger, F. E.; Mendez-Lazaro, P.; Chen, F. R.

    2016-02-01

    Suspended sediments in coastal ecosystems reduce light penetration, degrade water quality, and inhibit primary production. In this study, a 15-year Moderate Resolution Imaging Spectroradiometer (MODIS/Terra) turbidity time-series was developed for use in the estuaries of the Gulf of Mexico (GOM). Remote-sensing reflectance (Rrs) at 645 nm and 250-m resolution was validated with in-situ turbidity measurements in these estuaries: Coastal Bend Bays (TX), Galveston Bay (TX), Barataria and Terrebonne Bays (LA), Mobile Bay (AL), Tampa Bay (FL), Sarasota Bay (FL), and Charlotte Harbor (FL). Mean values of turbidity over the time-series ranged from 2.5 NTU to over 10 NTU. Turbidity patterns exhibited seasonal cycles with peak values generally found during spring months, although there is considerable variability in the timing of peak turbidity. Episodes of elevated turbidity ranged from 6 episodes in Galveston Bay to 15 in Mobile Bay. The spatial extent of elevated turbidity within estuaries, frequency and duration of turbidity events, and potential driving factors behind episodes of elevated turbidity were also examined.

  11. A reflectivity profilometer for the optical characterisation of graded reflectivity mirrors in the 250 nm - 1100 nm spectral region

    International Nuclear Information System (INIS)

    Colucci, Alessandro; Nichelatti, Enrico

    1998-04-01

    It's developed the prototype of an instrument that can be used for the optical characterisation of graded reflectivity mirrors at any wavelength in the spectral region from 250 nm to 1100 nm. The instrument utilises a high-pressure Xe arc lamp as light source. Light is spectrally filtered by means of a grating monochromator. The sample is illuminated with an image of the monochromator exit slit. After reflection from the sample, this image is projected onto a 1024-elements charge-coupled device linear array driven by a digital frame board and interfaced with a personal computer. It's tested the instrument accuracy by comparing measurement results with the corresponding ones obtained by means of a laser scanning technique. Measurement Rms repeatability has been estimated to be approximately of 0.8% [it

  12. Radiation from an equilibrium CO2-N2 plasma in the [250-850 nm] spectral region: II. Spectral modelling

    International Nuclear Information System (INIS)

    Silva, M Lino da; Vacher, D; Andre, P; Faure, G; Dudeck, M

    2008-01-01

    In the first part of this work, described in a previous paper, the thermodynamic conditions in an atmospheric pressure inductively coupled CO 2 -N 2 plasma have been determined, and the radiation emission spectrum has been measured and calibrated in the [250-850 nm] spectral region. In the second part of this work, a synthetic radiation spectrum is obtained taking into account (a) the geometry of the plasma torch and (b) the local thermodynamic conditions of the plasma. This synthetic spectrum has then been compared against the measured spectrum. The good agreement between the two spectra allows validating the spectral database of the line-by-line code SPARTAN for the simulation of the radiative emission of CO 2 -N 2 plasmas from the near-UV to the near-IR spectral region.

  13. Study for optimization of a {sup 60} Co industrial irradiator of 250 k Ci.; Estudio para la optimizacion de un irradiador industrial de {sup 60} Co de 250 kCi.

    Energy Technology Data Exchange (ETDEWEB)

    Pina V, G

    1996-12-31

    This work presents results of a benchmark between calculated and experimental absorbed dose values for a typical product, in a {sup 60} Co industrial irradiator, located at ININ, Mexico. The goal of this work is to reach a {+-} 10 % approximation between both values. ININ {sup 60} Co industrial irradiator is a two level, two layer system with overlapping product configuration, 56 irradiation positions with an activity of around 250 k Ci. Calculated values were obtained by QAD-CGGP code. This code uses a point kernel technique, build-up factors fitting was done by geometrical progression and combinatorial geometry was used for 3 D system description. Main code modifications were related with source simulation by punctual sources and energy spectrum (16 energy groups) and anisotropic emission were also considered. Experimental data were obtained from routine dosimetry which was done with red acrylic pellets; they were irradiated together the product in predetermined positions, for 36 maximum and minimum absorbed dose values. Typical product was polypropylene Petri dish packages, apparent density 0.13 g/cm{sup 3}. It was chosen because regular geometry (2 packages per full irradiator container) and enough amount for considering homogeneous loading inside irradiation chamber. Required minimum dose was 15 kGy. Results showed a 8% variation between calculated and experimental values for maximum absorbed dose (18.2 kGy vs 16.8 kGy) and 3 % variation for minimum absorbed dose (13.8 kGy vs 14.3 kGy); these results fixed with the original proposal. (Author).

  14. Production of DNA minicircles less than 250 base pairs through a novel concentrated DNA circularization assay enabling minicircle design with NF-κB inhibition activity.

    Science.gov (United States)

    Thibault, Thomas; Degrouard, Jeril; Baril, Patrick; Pichon, Chantal; Midoux, Patrick; Malinge, Jean-Marc

    2017-03-17

    Double-stranded DNA minicircles of less than 1000 bp in length have great interest in both fundamental research and therapeutic applications. Although minicircles have shown promising activity in gene therapy thanks to their good biostability and better intracellular trafficking, minicircles down to 250 bp in size have not yet been investigated from the test tube to the cell for lack of an efficient production method. Herein, we report a novel versatile plasmid-free method for the production of DNA minicircles comprising fewer than 250 bp. We designed a linear nicked DNA double-stranded oligonucleotide blunt-ended substrate for efficient minicircle production in a ligase-mediated and bending protein-assisted circularization reaction at high DNA concentration of 2 μM. This one pot multi-step reaction based-method yields hundreds of micrograms of minicircle with sequences of any base composition and position and containing or not a variety of site-specifically chemical modifications or physiological supercoiling. Biochemical and cellular studies were then conducted to design a 95 bp minicircle capable of binding in vitro two NF-κB transcription factors per minicircle and to efficiently inhibiting NF-κB-dependent transcriptional activity in human cells. Therefore, our production method could pave the way for the design of minicircles as new decoy nucleic acids. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

  15. Matrimid-JUC-62 and Matrimid-PCN-250 mixed matrix membranes displaying light-responsive gas separation and beneficial ageing characteristics for CO2/N2 separation.

    Science.gov (United States)

    Prasetya, Nicholaus; Teck, Anastasia A; Ladewig, Bradley P

    2018-02-13

    The performance of two generation-3 light-responsive metal-organic framework (MOF), namely JUC-62 and PCN-250, was investigated in a mixed matrix membrane (MMM) form. Both of them were incorporated inside the matrimid as the polymer matrix. Using our custom-designed membrane testing cell, it was observed that the MMMs showed up to 9% difference in CO 2 permeability between its pristine and UV-irradiated condition. This shows that the light-responsive ability of the light-responsive MOFs could still be maintained. Thus, this finding is applicable in designing a smart material. Apart from that, the MMMs also has the potential to be applied for post-combustion carbon capture. At loadings up to 15 wt%, both CO 2 permeability and CO 2 /N 2 ideal selectivity could be significantly improved and surpassed the value exhibited by most of the MOF-matrimid MMM. Lastly the long term performance of the MMM was also evaluated and it was observed that both MMM could maintain their performance up to 1 month with only a slight decrease in CO 2 permeability observed for 10 wt% PCN-250-matrimid. This study then opens up the possibility to fabricate a novel anti-aging multifunctional membrane material that is applicable as a smart material and also in post combustion carbon capture applications.

  16. Generation of high-energy sub-20 fs pulses tunable in the 250-310 nm region by frequency doubling of a high-power noncollinear optical parametric amplifier.

    Science.gov (United States)

    Beutler, Marcus; Ghotbi, Masood; Noack, Frank; Brida, Daniele; Manzoni, Cristian; Cerullo, Giulio

    2009-03-15

    We report on the generation of powerful sub-20 fs deep UV pulses with 10 microJ level energy and broadly tunable in the 250-310 nm range. These pulses are produced by frequency doubling a high-power noncollinear optical parametric amplifier and compressed by a pair of MgF2 prisms to an almost transform-limited duration. Our results provide a power scaling by an order of magnitude with respect to previous works.

  17. Study for optimization of a 60 Co industrial irradiator of 250 k Ci

    International Nuclear Information System (INIS)

    Pina V, G.

    1995-01-01

    This work presents results of a benchmark between calculated and experimental absorbed dose values for a typical product, in a 60 Co industrial irradiator, located at ININ, Mexico. The goal of this work is to reach a ± 10 % approximation between both values. ININ 60 Co industrial irradiator is a two level, two layer system with overlapping product configuration, 56 irradiation positions with an activity of around 250 k Ci. Calculated values were obtained by QAD-CGGP code. This code uses a point kernel technique, build-up factors fitting was done by geometrical progression and combinatorial geometry was used for 3 D system description. Main code modifications were related with source simulation by punctual sources and energy spectrum (16 energy groups) and anisotropic emission were also considered. Experimental data were obtained from routine dosimetry which was done with red acrylic pellets; they were irradiated together the product in predetermined positions, for 36 maximum and minimum absorbed dose values. Typical product was polypropylene Petri dish packages, apparent density 0.13 g/cm 3 . It was chosen because regular geometry (2 packages per full irradiator container) and enough amount for considering homogeneous loading inside irradiation chamber. Required minimum dose was 15 kGy. Results showed a 8% variation between calculated and experimental values for maximum absorbed dose (18.2 kGy vs 16.8 kGy) and 3 % variation for minimum absorbed dose (13.8 kGy vs 14.3 kGy); these results fixed with the original proposal. (Author)

  18. Neanderthal use of fish, mammals, birds, starchy plants and wood 125-250,000 years ago.

    Directory of Open Access Journals (Sweden)

    Bruce L Hardy

    Full Text Available Neanderthals are most often portrayed as big game hunters who derived the vast majority of their diet from large terrestrial herbivores while birds, fish and plants are seen as relatively unimportant or beyond the capabilities of Neanderthals. Although evidence for exploitation of other resources (small mammals, birds, fish, shellfish, and plants has been found at certain Neanderthal sites, these are typically dismissed as unusual exceptions. The general view suggests that Neanderthal diet may broaden with time, but that this only occurs sometime after 50,000 years ago. We present evidence, in the form of lithic residue and use-wear analyses, for an example of a broad-based subsistence for Neanderthals at the site of Payre, Ardèche, France (beginning of MIS 5/end of MIS 6 to beginning of MIS 7/end of MIS 8; approximately 125-250,000 years ago. In addition to large terrestrial herbivores, Neanderthals at Payre also exploited starchy plants, birds, and fish. These results demonstrate a varied subsistence already in place with early Neanderthals and suggest that our ideas of Neanderthal subsistence are biased by our dependence on the zooarchaeological record and a deep-seated intellectual emphasis on big game hunting.

  19. Optical emission from a small scale model electric arc furnace in 250-600 nm region.

    Science.gov (United States)

    Mäkinen, A; Niskanen, J; Tikkala, H; Aksela, H

    2013-04-01

    Optical emission spectroscopy has been for long proposed for monitoring and studying industrial steel making processes. Whereas the radiative decay of thermal excitations is always taking place in high temperatures needed in steel production, one of the most promising environment for such studies are electric arc furnaces, creating plasma in excited electronic states that relax with intense characteristic emission in the optical regime. Unfortunately, large industrial scale electric arc furnaces also present a challenging environment for optical emission studies and application of the method is not straightforward. To study the usability of optical emission spectroscopy in real electric arc furnaces, we have developed a laboratory scale DC electric arc furnace presented in this paper. With the setup, optical emission spectra of Fe, Cr, Cr2O3, Ni, SiO2, Al2O3, CaO, and MgO were recorded in the wavelength range 250-600 nm and the results were analyzed with the help of reference data. The work demonstrates that using characteristic optical emission, obtaining in situ chemical information from oscillating plasma of electric arc furnaces is indeed possible. In spite of complications, the method could possibly be applied to industrial scale steel making process in order to improve its efficiency.

  20. A cross section measurement of charm hyperons Ξc+ and Ξc0 in 250 GeV p/K/π-nucleon interactions

    International Nuclear Information System (INIS)

    Francisco, J.; Vergara, A.

    1995-01-01

    Fermilab Experiment 769 used a charge-selected, hadron beam of mean energy 250 GeV/c, composed of pions, kaons, and protons, impinging on beryllium, aluminum, copper and tungsten targets. Using a sample of approximately 4000 Ξ s - → Λ 0 π - decays, measurements of the charm baryon forward cross sections times branching ratio π ± N → Ξ c + X and π ± N → Ξ c 0 X are presented. Upper limits on α x BR are also determined for the states Ξ c + → Ξ s - π + π + and Ξ c 0 → Ξ s - π + produced in (p, π + , π - , K + , K - )-nucleon interactions

  1. Study of SiO{sub 2} surface sputtering by a 250-550 keV He{sup +} ion beam during high-resolution Rutherford backscattering measurements

    Energy Technology Data Exchange (ETDEWEB)

    Kusanagi, Susumu [Materials Analysis Laboratory, Advanced Design Technology Center, Sony Corporation, 4-16-1 Okata Atsugi-shi, Kanagawa 243-0021 (Japan)]. E-mail: susumu.kusanagi@jp.sony.com; Kobayashi, Hajime [Materials Analysis Laboratory, Advanced Design Technology Center, Sony Corporation, 4-16-1 Okata Atsugi-shi, Kanagawa 243-0021 (Japan)

    2006-08-15

    Decreases in oxygen signal intensities in spectra of high-resolution Rutherford backscattering spectrometry (HRBS) were observed during measurements on a 5-nm thick SiO{sub 2} layer on a Si substrate when irradiated by 250-550 keV He{sup +} ions. Shifts in an implanted arsenic profile in a 5-nm thick SiO{sub 2}/Si substrate were also observed as a result of He{sup +} ion irradiation. These results lead to the conclusion that the SiO{sub 2} surface was sputtered by He{sup +} ions in this energy range.

  2. Remarkable changes in interface O vacancy and metal-oxide bonds in amorphous indium-gallium-zinc-oxide thin-film transistors by long time annealing at 250 °C

    International Nuclear Information System (INIS)

    Chowdhury, Md Delwar Hossain; Um, Jae Gwang; Jang, Jin

    2014-01-01

    We have studied the effect of long time post-fabrication annealing on negative bias illumination stress (NBIS) of amorphous indium-gallium-zinc-oxide (a-IGZO) thin-film-transistors. Annealing for 100 h at 250 °C increased the field effect mobility from 14.7 cm 2 /V s to 17.9 cm 2 /V s and reduced the NBIS instability remarkably. Using X-ray photoelectron spectroscopy, the oxygen vacancy and OH were found to exist at the interfaces of a-IGZO with top and bottom SiO 2 . Long time annealing helps to decrease the vacancy concentration and increase the metal-oxygen bonds at the interfaces; this leads to increase in the free carrier concentrations in a-IGZO and field-effect mobility. X-ray reflectivity measurement indicated the increment of a-IGZO film density of 5.63 g cm −3 to 5.83 g cm −3 (3.4% increase) by 100 h annealing at 250 °C. The increase in film density reveals the decrease of O vacancy concentration and reduction of weak metal-oxygen bonds in a-IGZO, which substantially helps to improve the NBIS stability

  3. European Collaboration for High-Resolution Measurements of Neutron Cross Sections between 1 MeV and 250 MeV

    CERN Multimedia

    Leal, L C; Kitis, G; Guber, K H; Yuasa nakagawa, K; Koehler, P E; Quaranta, A

    2002-01-01

    The experimental determination of neutron cross section data has always been of primary importance in Nuclear Physics. Many of the salient features of nuclear levels and densities can be determined from the resonant structure of such cross sections and of their decay scheme. An associated importance of precise neutron induced reaction cross sections has resulted from the worldwide interest in Accelerator Driven Systems (ADS) that has emerged at CERN and elsewhere. Many applications, such as accelerator-based transmutation of nuclear waste, energy amplification medical research, astrophysical applications and also fusion research require nuclear data that quantitatively and qualitatively go beyond the presently available traditional evaluation.\\\\ \\\\We consider a spallation driven TOF facility at the CERN-PS with an unprecedented neutron flux (1000 times the existing ones) in the broad energy range between 1 eV and 250 MeV and with very high energy resolution. The present concept for an intense neutron source m...

  4. A gas/liquid chromatographic-mass spectrometric method for the rapid screening of 250 pesticides in aqueous matrices

    Energy Technology Data Exchange (ETDEWEB)

    Chandramouli, B.; Harvan, D.; Brittain, S.; Hass, R. [Eno River Labs, LLC. Durham, NC (United States)

    2004-09-15

    Pesticide residues in food present a potentially serious and significant cause for concern. Many pesticides have been associated with significant health effects to the nervous and endocrine systems and some have been deemed carcinogenic. There are many well-established techniques for pesticide analysis. However, commercial pesticide methods have traditionally only been available for specific pesticide families, such as chlorinated pesticides or herbicides, and at detection limits ranging from 0.05 ppb to 1 ppm in aqueous matrices. Techniques that can quickly screen for the presence/absence of pesticide residues in food matrices are critical in ensuring the safety of food and water. This paper outlines a combined Gas Chromatographic-High Resolution Mass Spectrometric (GC-HRMS) and Liquid Chromatographic Tandem Mass Spectrometric (LC-MS/MS) screening assay for 250 pesticides that was developed for use in water, and soda samples at screening levels ranging from 0.1-5 ppb. The pesticides selected have been identified by the European Union as being of concern and the target of possible legislation. The list encompasses a variety of pesticide classes and compound groupings.

  5. VBFNLO. A patron level Monte Carlo for processes with electroweak bosons. Manual for Version 2.5.0

    Energy Technology Data Exchange (ETDEWEB)

    Arnold, K.; Bellm, J. [Karlsruhe Institute of Technology, Karlsruhe (Germany). Inst. fuer Theoretische Physik; Bozzi, G. [Milano-Bicocca Univ. (Italy). Dipt. di Fisica; INFN, Sezione di Milano-Bicocca (IT)] (and others)

    2011-08-15

    VBFNLO is a flexible parton level Monte Carlo program for the simulation of vector boson fusion, double and triple vector boson production in hadronic collisions at next-to-leading order (NLO) in the strong coupling constant, as well as Higgs boson plus two jet production via gluon fusion at the one-loop level. In the new release - Version 2.5.0 - several new processes have been added at NLO QCD: vector boson fusion production of a Higgs boson plus a photon, vector boson fusion production of a photon, W{gamma} and WZ production plus a hadronic jet and the triboson production processes WW{gamma}, ZZ{gamma}, WZ{gamma}, W{gamma}{gamma}, Z{gamma}{gamma} and {gamma}{gamma}{gamma}. The code has been extended to run in the Minimal Supersymmetric Standard Model (MSSM), and electroweak corrections to Higgs boson production via weak boson fusion have been included. Anomalous gauge boson couplings can be used in new processes and the Three-Site Higgsless model has been implemented for several processes. The simulation of Higgs boson production via gluon fusion has been improved. (orig.)

  6. Bioequivalence evaluation of two brands of amoxicillin/clavulanic acid 250/125 mg combination tablets in healthy human volunteers: use of replicate design approach.

    Science.gov (United States)

    Idkaidek, Nasir M; Al-Ghazawi, Ahmad; Najib, Naji M

    2004-12-01

    The purpose of this study was to apply a replicate design approach to a bioequivalence study of amoxicillin/clavulanic acid combination following a 250/125 mg oral dose to 23 subjects, and to compare the analysis of individual bioequivalence with average bioequivalence. This was conducted as a 2-treatment 2-sequence 4-period crossover study. Average bioequivalence was shown, while the results from the individual bioequivalence approach had no success in showing bioequivalence. In conclusion, the individual bioequivalence approach is a strong statistical tool to test for intra-subject variances and also subject-by-formulation interaction variance compared with the average bioequivalence approach. copyright (c) 2004 John Wiley & Sons, Ltd.

  7. Mapping irrigated lands at 250-m scale by merging MODIS data and National Agricultural Statistics

    Science.gov (United States)

    Pervez, Md Shahriar; Brown, Jesslyn F.

    2010-01-01

    Accurate geospatial information on the extent of irrigated land improves our understanding of agricultural water use, local land surface processes, conservation or depletion of water resources, and components of the hydrologic budget. We have developed a method in a geospatial modeling framework that assimilates irrigation statistics with remotely sensed parameters describing vegetation growth conditions in areas with agricultural land cover to spatially identify irrigated lands at 250-m cell size across the conterminous United States for 2002. The geospatial model result, known as the Moderate Resolution Imaging Spectroradiometer (MODIS) Irrigated Agriculture Dataset (MIrAD-US), identified irrigated lands with reasonable accuracy in California and semiarid Great Plains states with overall accuracies of 92% and 75% and kappa statistics of 0.75 and 0.51, respectively. A quantitative accuracy assessment of MIrAD-US for the eastern region has not yet been conducted, and qualitative assessment shows that model improvements are needed for the humid eastern regions where the distinction in annual peak NDVI between irrigated and non-irrigated crops is minimal and county sizes are relatively small. This modeling approach enables consistent mapping of irrigated lands based upon USDA irrigation statistics and should lead to better understanding of spatial trends in irrigated lands across the conterminous United States. An improved version of the model with revised datasets is planned and will employ 2007 USDA irrigation statistics.

  8. Remarkable changes in interface O vacancy and metal-oxide bonds in amorphous indium-gallium-zinc-oxide thin-film transistors by long time annealing at 250 °C

    Energy Technology Data Exchange (ETDEWEB)

    Chowdhury, Md Delwar Hossain; Um, Jae Gwang; Jang, Jin, E-mail: jjang@khu.ac.kr [Advanced Display Research Center and Department of Information Display, Kyung Hee University, Seoul 130-701 (Korea, Republic of)

    2014-12-08

    We have studied the effect of long time post-fabrication annealing on negative bias illumination stress (NBIS) of amorphous indium-gallium-zinc-oxide (a-IGZO) thin-film-transistors. Annealing for 100 h at 250 °C increased the field effect mobility from 14.7 cm{sup 2}/V s to 17.9 cm{sup 2}/V s and reduced the NBIS instability remarkably. Using X-ray photoelectron spectroscopy, the oxygen vacancy and OH were found to exist at the interfaces of a-IGZO with top and bottom SiO{sub 2}. Long time annealing helps to decrease the vacancy concentration and increase the metal-oxygen bonds at the interfaces; this leads to increase in the free carrier concentrations in a-IGZO and field-effect mobility. X-ray reflectivity measurement indicated the increment of a-IGZO film density of 5.63 g cm{sup −3} to 5.83 g cm{sup −3} (3.4% increase) by 100 h annealing at 250 °C. The increase in film density reveals the decrease of O vacancy concentration and reduction of weak metal-oxygen bonds in a-IGZO, which substantially helps to improve the NBIS stability.

  9. Hemominas: aplicação e impacto do instrumento de auto-avaliação de 250 pontos do Gespública Hemominas Foundation: utilization and impact of the Gespublica (government administration 250-point self-evaluation questionnaire

    Directory of Open Access Journals (Sweden)

    Daniela O. W. Rodrigues

    2008-04-01

    Full Text Available A experiência de um modelo de gestão, nas áreas de hematologia e hemoterapia, que transforme as práticas de gestão voltadas excessivamente para procedimentos, normas e relatórios, em estratégias focadas em resultados que determinam a satisfação do cidadão, é um desafio. A grande dificuldade da qualidade na gestão dos serviços públicos é atingir resultados efetivos capazes de reduzir ou eliminar problemas ou de acrescentar benefícios e valores desejados pela sociedade.1,3,15 A Hemominas, ciente da importância do seu papel como prestadora de serviços em área crítica e de vital importância, elaborou estratégias para uma administração gerencial fundamentada em valores constitucionais públicos, institucionais, princípios da qualidade e com metas definidas e acompanhadas através de um sistema de medição. A Fundação Hemominas opera em rede, com administração e coordenação técnica centralizadas em Belo Horizonte, e possui 23 unidades regionais localizadas no estado de Minas Gerais. Na busca de um modelo gerencial moderno e focado em resultados, o Programa da Qualidade Fundação Hemominas (PQFH implantou os critérios de excelência em gestão em sete unidades da Fundação. As unidades realizaram a auto-avaliação com o instrumento de 250 pontos do Gespública, com validação externa e posterior certificação e reconhecimento pelas boas práticas pelo Ministério do Planejamento e Gestão.The experience of an administration model in hematology and blood transfusion, which transforms administration practices excessively focused on procedures, norms and strategy into approaches based on results that determine the citizens' satisfaction, presents a challenge. The great difficulty in the quality of administration of a public service is to obtain effective results by decreasing or eliminating problems, or by adding benefits and values expected by society. Hemominas, aware of the importance of its role as a service

  10. Anomalous decrease of resistance at 250 K in ultrathin Au-Nb film on single-crystal silicon

    International Nuclear Information System (INIS)

    Yamamoto, H.; Kawashima, T.; Tanaka, M.

    1986-01-01

    Ultrathin Au-Nb films as thin as 0.2 about 10 nm were deposited on clean surfaces of single-crystal silicon in order to investigate interfacial excitonic superconductivity. The samples were classified into two types, Nb-Au/Si and Au-Nb-Au/Si. In the latter case, the secondary Au film was deposited on the former sample cooled by liquid nitrogen. In the Nb-Au/ Si type of sample, a sheet resistance, R /SUB s/ at room temperature abruptly increased from 10 3 Ωsq -1 order to about 10 5 Ωsq -1 in several days a few months after the sample preparation. Then the sample showed an anomalous decrease of R /SUB s/ at about 250 K and an approximately null resistance at lower temperatures. This phenomenon was not so stable and was observed only for a few days. The Au-Nb-Au/Si type of sample showed low R /SUB s/ (10 2 about 10 3 Ωsq -1 ) at room temperature. A decrease and disappearance of R /SUB s/ were also observed at about 240 K in the sample with comparatively good reproducibility. These phenomena are discussed qualitatively, based on the excitonic superconductive model for an interface of metal/semiconductor by Allender, Bray, and Bardeen

  11. Geochemical provenance of anomalous metal concentrations in stream sediments in the Ashton 1:250,000 quadrangle, Idaho/Montana/Wyoming

    International Nuclear Information System (INIS)

    Shannon, S.S. Jr.

    1982-01-01

    Stream-sediment samples from 1500 sites in the Ashton, Idaho/Montana/Wyoming 1:250,000 quadrangle were analyzed for 45 elements. Almost all samples containing anomalous concentrations (exceeding one standard deviation above the mean value of any element) were derived from drainage basins underlain by Quaternary rhyolite, Tertiary andesite or Precambrian gneiss and schist. Aluminum, barium, calcium, cobalt, iron, nickel, magnesium, scandium, sodium, strontium, and vanadium have no andesite provenance. Most anomalous manganese, europium, hafnium, and zirconium values were derived from Precambrian rocks. All other anomalous elemental concentrations are related to Quaternary rhyolite. This study demonstrates that multielemental stream-sediment analyses can be used to infer the provenance of stream sediments. Such data are available for many parts of the country as a result of the National Uranium Resource Evaluation. This study suggests that stream-sediment samples collected in the Rocky Mountains can be used either as pathfinders or as direct indicators to select targets for mineral exploration for a host of metals

  12. Neutron capture and fission cross section of Americium-243 in the energy range from 5 to 250 keV

    International Nuclear Information System (INIS)

    Wisshak, K.; Kaeppeler, F.

    1983-04-01

    The neutron capture and subthreshold fission cross section of 243 Am was measured in the energy range from 5 to 250 keV using 197 Au and 235 U as the respective standards. Neutrons were produced via the 7 Li(p,n) and the T(p,n) reaction with the Karlsruhe 3-MV pulsed Van de Graaff accelerator. Capture events were detected by two MoxonRae detectors with graphite and bismuthgraphite converters, respectively. Fission events were registered by a NE-213 liquid scintillator with pulse-shape discriminator equipment. Flight paths as short as 50-70 mm were used to obtain optimum signal-to-background ratio. After correction for the different efficiency of the individual converter materials the capture cross section could be determined with a total uncertainty of 3-6%. The respective values for the fission cross section are 8-12%. The results are compared to predictions of recent evaluations, which in some cases are severely discrepant. (orig.)

  13. Electrophysiological correlates of social information processing for detecting agents in social interaction scenes: P200 and N250 components

    Directory of Open Access Journals (Sweden)

    Crivelli Davide

    2016-04-01

    Full Text Available According to interaction theories, the detection of situated agents and the understanding of their intentions and mental states are mediated by smart perceptual and embodied mechanisms. While the network supporting agency-attribution, action understanding, and grasping of others’ mental state is quite known, the actual mental chronometry of such social perception processes is still not clear. We then designed an exploratory study to investigate electrophysiological correlates (ERPs and source localization of information-processing for the detection of potential agents in realistic interaction scenes. Morphological and statistical analyses of electrophysiological data highlighted that the manipulation the nature of a potential agent, the gesture it executed and the relative position of an interagent was differently associated to the modulation of specific relevant middle-latency ERP components, labelled as P200 and N250, and of their relative intra-cortical current density distribution within the first 300 ms from the appearance of the stimulus.

  14. DEVELOPMENT OF HIGH-RISE CONSTRUCTION IN THE CITIES WITH POPULATION FROM 250 TO 500 THOUSAND INHABITANTS (on the example of the cities of the Ural Federal District

    Directory of Open Access Journals (Sweden)

    Olga Mikhaylovna Shentsova

    2017-09-01

    Full Text Available In article history of construction of high-rise buildings, features of perception of high-rise buildings in the urban environment what factors influence the choice of the site of high-rise buildings are considered. Such concepts as “skyscraper”, “a high-rise dominant” reveal. Also, the analysis of existence of high-rise buildings of the large cities with population from 250 to 500 thousand residents of the Ural Federal District is provided: Barrow, Nizhny Tagil, Nizhnevartovsk, Surgut and Magnitogorsk. And also the analysis of a town-planning situation of Magnitogorsk where the possible, most probable and offered places for an arrangement of high-rise buildings on crossing or end of axes of streets are revealed is given. Work purpose – the analysis of high-rise construction in the large cities of the Ural Federal District with population from 250 to 500 thousand inhabitants. Method or methodology of carrying out work: in article methods of the theoretical and visual analysis, observation, and also studying literary and the Internet of sources were used. Results: the systematized theoretical material in the field of architecture and town planning of the cities of the Ural Federal District is received. Scope of results: the received results can be applied in the field of architectural education and practical architectural activities.

  15. Body-surface pressure data on two monoplane-wing missile configurations with elliptical cross sections at Mach 2.50

    Science.gov (United States)

    Allen, J. M.; Hernandez, G.; Lamb, M.

    1983-01-01

    Tabulated body surface pressure data for two monoplane-wing missile configurations are presented and analyzed. Body pressure data are presented for body-alone, body-tail, and body-wing-tail combinations. For the lost combination, data are presented for tail-fin deflection angles of 0 deg and 30 deg to simulate pitch, yaw, and roll control for both configurations. The data cover angles of attack from -5 deg to 25 deg and angles of roll from 0 deg to 90 deg at a Mach number of 2.50 and a Reynolds number of 6.56 x 1,000,000 per meter. Very consistent, systematic trends with angle of attack and angle of roll were observed in the data, and very good symmetry was found at a roll angle of 0 deg. Body pressures depended strongly on the local body cross-section shape, with very little dependence on the upstream shape. Undeflected fins had only a small influence on the pressures on the aft end of the body; however, tail-fin deflections caused large changes in the pressures.

  16. Comparison of 250 MHz electron spin echo and continuous wave oxygen EPR imaging methods for in vivo applications

    Science.gov (United States)

    Epel, Boris; Sundramoorthy, Subramanian V.; Barth, Eugene D.; Mailer, Colin; Halpern, Howard J.

    2011-01-01

    Purpose: The authors compare two electron paramagnetic resonance imaging modalities at 250 MHz to determine advantages and disadvantages of those modalities for in vivo oxygen imaging. Methods: Electron spin echo (ESE) and continuous wave (CW) methodologies were used to obtain three-dimensional images of a narrow linewidth, water soluble, nontoxic oxygen-sensitive trityl molecule OX063 in vitro and in vivo. The authors also examined sequential images obtained from the same animal injected intravenously with trityl spin probe to determine temporal stability of methodologies. Results: A study of phantoms with different oxygen concentrations revealed a threefold advantage of the ESE methodology in terms of reduced imaging time and more precise oxygen resolution for samples with less than 70 torr oxygen partial pressure. Above∼100 torr, CW performed better. The images produced by both methodologies showed pO2 distributions with similar mean values. However, ESE images demonstrated superior performance in low pO2 regions while missing voxels in high pO2 regions. Conclusions: ESE and CW have different areas of applicability. ESE is superior for hypoxia studies in tumors. PMID:21626937

  17. Comparison of 250 MHz R10K Origin 2000 and 400 MHz Origin 2000 Using NAS Parallel Benchmarks

    Science.gov (United States)

    Turney, Raymond D.; Thigpen, William W. (Technical Monitor)

    2001-01-01

    This report describes results of benchmark tests on Steger, a 250 MHz Origin 2000 system with R10K processors, currently installed at the NASA Ames National Advanced Supercomputing (NAS) facility. For comparison purposes, the tests were also run on Lomax, a 400 MHz Origin 2000 with R12K processors. The BT, LU, and SP application benchmarks in the NAS Parallel Benchmark Suite and the kernel benchmark FT were chosen to measure system performance. Having been written to measure performance on Computational Fluid Dynamics applications, these benchmarks are assumed appropriate to represent the NAS workload. Since the NAS runs both message passing (MPI) and shared-memory, compiler directive type codes, both MPI and OpenMP versions of the benchmarks were used. The MPI versions used were the latest official release of the NAS Parallel Benchmarks, version 2.3. The OpenMP versions used were PBN3b2, a beta version that is in the process of being released. NPB 2.3 and PBN3b2 are technically different benchmarks, and NPB results are not directly comparable to PBN results.

  18. Guideline concerning financial aid by the state to '250 MW wind' wind power plants within the framework of the third programme 'Energy research and energy technologies'

    International Nuclear Information System (INIS)

    1994-01-01

    An industrial-scale wind power experiment will receive financial aid for several years. An installed power of 250 MW is to be reached within a 5-year period if possible. The BMFT will grant financial aid on a per kWh basis up to a maximum sum, or - if desired by certain applicants - in the form of an investment aid, both for a maximum period of 10 years from the start-up of the wind power plant. The BMFT will also finance a scientific programme for measurement and evaluation. (orig.) [de

  19. Evaluation of mechanical properties of Z250 composite resin light-cured by different methods Avaliação de propriedades mecânicas da resina composta Z250 fotoativada com diferentes métodos

    Directory of Open Access Journals (Sweden)

    Andresa Carla Obici

    2005-12-01

    Full Text Available This study evaluated some mechanical parameters of Z250 composite resin using different light-curing methods. Ten specimens were prepared for each mechanical test group with different dimensions according to the test. Light-curing was performed by: a. continuous light (800mW/cm²-40s; b. exponential light (0-800mW/cm²-40s; c. intermittent light (2s-600mW/cm²; 2s without light-80s; d. stepped light (10s-150mW/cm²; 30s-650mW/cm²; e. PAC (1320mW/cm²-3s; f. LED (350mW/cm²-40s. After 24 ± 1 h, the specimens were loaded at a crosshead speed of 0.5 mm/min until fracture. The mechanical properties were calculated and analyzed by ANOVA and Tukey test (5%. The results showed that the highest compressive strength values were found for the continuous, exponential, intermittent and stepped light methods, whereas PAC and LED obtained the lowest values. LED, stepped light, PAC, exponential and continuous light presented the highest values for diametral tensile strength. The intermittent light showed the lowest value, which was significantly lower than the value obtained for LED only. Flexural strength results were not significantly different between all light-curing methods. Finally, the highest modulus of elasticity values were obtained for LED, exponential, continuous and intermittent light, whereas PAC and stepped light showed the lowest values. The mechanical properties were affected by light-curing methods employed.Este estudo avaliou algumas propriedades mecânicas da resina composta Z250 usando diferentes métodos de fotoativação. Dez amostras foram preparadas para cada grupo, com diferentes dimensões de acordo com o ensaio. Os métodos de fotoativação foram: a luz contínua (800mW/cm²-40s; b luz exponencial (0-800mW/cm²-40s; c luz intermitente (2s-600mW/cm²; 2s sem luz-80s; d dupla intensidade (10s-150mW/cm²; 30s-650mW/cm²; e PAC (1320mW/cm²-3s; f LED (350mW/cm²-40s. Após 24 ± 1 h, as amostras foram carregadas até fraturar (v=0

  20. Study on space-time structure of Higgs jet with the HBT correlation method in e{sup +}e{sup -} collision at √(s) = 250 GeV

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Hong-ge; Chen, Gang [China University of Geosciences, School of Mathematics and Physics, Wuhan (China); Li, Di-kai [China University of Geosciences, School of Mathematics and Physics, Wuhan (China); Shanghai Jiao Tong University, School of Physics and Astronomy, Shanghai (China); Li, Liang [Shanghai Jiao Tong University, School of Physics and Astronomy, Shanghai (China)

    2017-10-15

    The space-time structure of the Higgs boson decaying into hadron-jets (Higgs jets) is carefully studied with the HBT correlation method using e{sup +}e{sup -} collision events produced by the Monte Carlo generator PYTHIA 8.219 at √(s) = 250 GeV. The measurement of the Higgs boson radius and decay lifetime are derived from the HBT correlation of the final state pions, with an upper bound of R{sub H} ≤ 1.03 ± 0.05 fm and τ{sub H} ≤ (1.29 ± 0.15) x 10{sup -7} fs. This result is consistent with CMS data. (orig.)

  1. Electrochemical investigations of the resistance of Inconel 600, Incoloy 800, and Type 347 stainless steel to pitting corrosion in faulted PWR secondary water at 150 to 250 C

    International Nuclear Information System (INIS)

    Hickling, J.; Wieling, N.

    1981-01-01

    Determinations of critical pitting potentials were carried out at temperatures of 150, 200, and 250 C on three corrosion resistant alloys important in the construction of nuclear steam generators. The results are assessed in terms of the effects on pitting resistance of chloride (as NaCl) and phosphate (as Na/sub 2/ HPO/sub 4/) contents of the water and test temperature. A comparison of material behavior was obtained for each set of test conditions. 18 refs

  2. Soil property maps of Africa at 250 m resolution

    Science.gov (United States)

    Kempen, Bas; Hengl, Tomislav; Heuvelink, Gerard B. M.; Leenaars, Johan G. B.; Walsh, Markus G.; MacMillan, Robert A.; Mendes de Jesus, Jorge S.; Shepherd, Keith; Sila, Andrew; Desta, Lulseged T.; Tondoh, Jérôme E.

    2015-04-01

    Vast areas of arable land in sub-Saharan Africa suffer from low soil fertility and physical soil constraints, and significant amounts of nutrients are lost yearly due to unsustainable soil management practices. At the same time it is expected that agriculture in Africa must intensify to meet the growing demand for food and fiber the next decades. Protection and sustainable management of Africa's soil resources is crucial to achieve this. In this context, comprehensive, accurate and up-to-date soil information is an essential input to any agricultural or environmental management or policy and decision-making model. In Africa, detailed soil information has been fragmented and limited to specific zones of interest for decades. To help bridge the soil information gap in Africa, the Africa Soil Information Service (AfSIS) project was established in 2008. AfSIS builds on recent advances in digital soil mapping, infrared spectroscopy, remote sensing, (geo)statistics, and integrated soil fertility management to improve the way soils are evaluated, mapped, and monitored. Over the period 2008-2014, the AfSIS project has compiled two soil profile data sets (about 28,000 unique locations): the Africa Soil Profiles (legacy) database and the AfSIS Sentinel Site (new soil samples) database -- the two data sets represent the most comprehensive soil sample database of the African continent to date. In addition a large set of high-resolution environmental data layers (covariates) was assembled. The point data were used in the AfSIS project to generate a set of maps of key soil properties for the African continent at 250 m spatial resolution: sand, silt and clay fractions, bulk density, organic carbon, total nitrogen, pH, cation-exchange capacity, exchangeable bases (Ca, K, Mg, Na), exchangeable acidity, and Al content. These properties were mapped for six depth intervals up to 2 m: 0-5 cm, 5-15 cm, 15-30 cm, 30-60 cm, 60-100 cm, and 100-200 cm. Random forests modelling was used to

  3. Foundations and anchors for a 250 m span arch bridge in la Palma Island (Canaries); Cimentaciones y anclajes para la construccion del Arco de los tilos, de 250 m. de luz, en la isla de la Palma (Canarias)

    Energy Technology Data Exchange (ETDEWEB)

    Simic Sureda, D.

    2008-07-01

    There are no simple procedures to estimate the bearing capacity of direct foundations on rock due to its anisotropy, as the criteria have to take into account different features concerning the rock discontinuities (spacing, orientation, opening, persistence,...) as well as other aspects concerning the rock matrix, particularly its strength when it is low. In this sense, the volcanic formations of the Canary Island pose important difficulties to the designer of foundations given their highly anisotropic fabric, which is the result of a complex origin where the basalt sheets alternate with fragmentary material of pyroclastic nature. This volcanic building is frequently intersected by old vents, in the guise of pipes plugged with broken fragments of low compacity. In a valley of highly dissected steep slopes of such geology an arch bridge has been designed and built with a span between supports of 250 m. This paper describes the analysis that was carried out to take into account the particularities of rock anisotropy and the foundations geometry in very steep slopes. The construction problems are also addressed in the paper, describing the grouting treatment that was needed in one of the supports due to the presence of an old vent. (Author) 7 refs.

  4. Report on acoustic and vibration measurements on 250 MVA transformer at St. Vital Station, Winnipeg, Manitoba

    International Nuclear Information System (INIS)

    Weissman, K.; McLoughlin, M.; Schott, R.; Tennese, G.; Daneryd, A.

    1998-09-01

    Vibroacoustic behaviour of a power transformer was characterized prior to employing active noise control (ANC) to control transformer noise. The effect of changes in temperature and loading conditions on the vibration pattern of the transformer tank received particular attention. The transformer quieting technology has been developed and implemented by QuietPower Systems of New York and Noise Cancellation Technologies Inc., of Maryland. Results of the study will be used to ensure that actuator placement is appropriate for each of the seasons experienced throughout the year, as well as to build boundary element and finite element models of the tank vibration and the associated radiated noise. Boundary element results show that the first four harmonics are the primary contributors to radiated noise. The finite element model used to examine the modal response of the tank structure showed high modal densities, even around the lower order harmonics (120 Hz). This can be interpreted to mean that statistical techniques normally associated with high frequency noise problems may be applicable here because of the high modal density. Results of the completed summer and winter measurements permit an evaluation of the effects of loading conditions, temperature and other environmental factors on transformer noise. Appendix B contains the results of numerical simulations on a 250 MVA transformer. 3 refs., 72 figs., 2 appendices

  5. X-Ray Diffraction Profile Analysis for Characterizing Isothermal Aging Behavior of M250 Grade Maraging Steel

    Science.gov (United States)

    Mahadevan, S.; Jayakumar, T.; Rao, B. P. C.; Kumar, Anish; Rajkumar, K. V.; Raj, Baldev

    2008-08-01

    X-ray diffraction (XRD) studies were carried out to characterize aging behavior of M250 grade maraging steel samples subjected to isothermal aging at 755 K for varying durations of 0.25, 1, 3, 10, 40, 70, and 100 hours. Earlier studies had shown typical features of precipitation hardening, wherein the hardness increased to a peak value due to precipitation of intermetallics and decreased upon further aging (overaging) due to reversion of martensite to austenite. Intermetallic precipitates, while coherent, are expected to increase the microstrain in the matrix. Hence, an attempt has been made in the present study to understand the microstructural changes in these samples using XRD line profile analysis. The anisotropic broadening with diffraction angle observed in the simple Williamson Hall (WH) plot has been addressed using the modified WH (mWH) approach, which takes into account the contrast caused by dislocations on line profiles, leading to new scaling factors in the WH plot. The normalized mean square strain and crystallite size estimated from mWH have been used to infer early precipitation and to characterize aging behavior. The normalized mean square strain has been used to determine the Avrami exponent in the Johnson Mehl Avrami (JMA) equation, which deals with the kinetics of precipitation. The Avrami exponent thus determined has matched well with values found by other methods, as reported in literature.

  6. In-situ analysis of the slip activity during tensile deformation of cast and extruded Mg-10Gd-3Y-0.5Zr (wt.%) at 250 °C

    Energy Technology Data Exchange (ETDEWEB)

    Wang, H. [National Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240 (China); The State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240 (China); Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824 (United States); Boehlert, C.J., E-mail: boehlert@egr.msu.edu [Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824 (United States); Wang, Q.D., E-mail: wangqudong@sjtu.edu.cn [National Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240 (China); The State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240 (China); Yin, D.D. [Key Laboratory of Advanced Materials Technology under Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031 (China); Ding, W.J. [National Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240 (China); The State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240 (China)

    2016-06-15

    The slip activity and slip interaction in tensile deformation of peak-aged cast and extruded Mg-10Gd-3Y-0.5Zr (wt.%) at 250 °C was investigated using in-situ scanning electron microscopy. Basal slip was the most likely system to be activated during the tensile deformation, while prismatic < a > and pyramidal < c + a > slip also contributed to the deformation. No twinning was observed. The number of non-basal slip systems accounted for ~ 36% of the total active slip systems for the cast alloy, while non-basal slip accounted for 12–17% of the total deformation observations in the extruded alloy. Multiple-slip was observed within grains, and the basal/prismatic pairing type dominated the multiple-slip observations. Slip transfer occurred across grain boundaries and most of the slip transfer observations showed basal-basal type. The involved slip systems of slip transfer pairs were always associated with the same < a > direction. The slip transfer occurred more easily at low angle boundaries (LABs) and boundaries with misorientations greater than 75°. - Highlights: • Slip deformation of a Mg-RE alloy at 250 °C was investigated using in-situ SEM. • The extruded-T5 GW103 alloy did not exhibit a high anisotropic behavior. • Multiple-slip was observed within grains, and basal/prismatic type dominated. • Slip transfer occurred and most of the observations showed basal-basal type. • Slip transfer occurred more easily at LABs and boundaries with misorientations > 75°.

  7. The relative biological effectiveness of 60Co γ-rays, 55 kVp X-rays, 250 kVp X-rays, and 11 MeV electrons at low doses

    International Nuclear Information System (INIS)

    Spadinger, I.; Palcic, B.

    1992-01-01

    The RBE of selected low-LET radiation modalities (55 kVp X- rays, 250 kVp X-rays, 60 Co γ-rays, and 11 MeV electrons) was investigated for survival of two cell lines (V79 and CHO). Detailed measurements were made in the 0 to 3 Gy dose range using an image cytometry device to accurately determine the number of cells assayed at each dose point. Data were also collected in the high dose range (0 to 10 Gy) using conventional counting and plating techniques. RBE values (#+- #1 SE) varied from 1.0±0.07 (V79 cells) and 1.2± 0.05 (CHO cells) at high doses to 1.3±0.07 (V79) and 1.4±0.1 (CHO) at low doses for 55 kVp X-rays, from 1.1±0.05 (V79) and 1.1±0.04 (CHO) at high doses to 1.1±0.06 (V79) and 1.2±0.2 (CHO) at low doses for 250 kVp X-rays, and from 1.1±0.08 (V79) and 1.0±0.04 (CHO) at high doses to 1.0±0.06 (V79) and 0.9±0.1 (CHO) at low doses for 11 MeV electrons. Only the low and high dose RBEs for 55 kVp X-rays relative to 60 Co γ-rays were significantly different. (author)

  8. Corrosion of stainless steel grades in molten NaOH/KOH eutectic at 250 C: AISI304 austenitic and 2205 duplex

    Energy Technology Data Exchange (ETDEWEB)

    Bozzini, B.; Bogani, F.; Scarselli, G. [Dipartimento di Ingegneria dell' Innovazione, Universita del Salento, Via per Monteroni, 73100 Lecce (Italy); Barella, S.; Boniardi, M. [Dipartimento di Meccanica, Politecnico di Milano, via La Masa 34, 20156 Milano (Italy); Giovannelli, G.; Natali, S. [Dipartimento DICMA, Universita di Roma ' ' La Sapienza' ' , via Eudossiana 18, 00184 Roma (Italy)

    2012-11-15

    The present paper focuses on the corrosion of an austenitic (AISI304) and a duplex (2205) stainless steel grade in molten KOH/NaOH 50 w/o eutectic at 250 C. Experimental activities have been performed consisting in electrochemical measurements (linear sweep voltammetry and electrochemical impedance spectrometry) complemented by metallographic (in-plane and cross-sectional SEM micrography), structural (X-ray diffractometry) and compositional (EDX line-profiles) characterisation of the materials attacked under electrochemically controlled conditions. Electrochemical measurements have shown that AISI304 exhibits a passivating behaviour, characterised by two passivation peaks and a transpassive threshold, while duplex, does not yield a clear indication of passivation. AISI304 was found to fail by intergranular corrosion and to be covered in both passive and transpassive conditions, by an incoherent scale, containing electrolyte species. Duplex samples, instead tends to fail by homogeneous attack and exhibit a range of scale structures, depending on the applied potential. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  9. Surface circulation patterns in the Gulf of California derived from MODIS Aqua 250 m

    Science.gov (United States)

    Martínez-Flores, G.; Salinas-González, F.; Gutiérrez de Velasco-Sanromán, G.; Godínez-Orta, L.

    2009-04-01

    The Gulf of California (GC) is a marginal elongated and semi-enclosed sea located at northwest of Mexico, between the Peninsula of Baja California and the mainland Mexico. The considered area average 150 km in width and 1500 km in length, from the mouth of the Colorado River to Cabo Corrientes, Jalisco. It has a maximum depth of 3600 m at the southern inlet and the northern region average 200 m in deep. The study of superficial circulation patterns in the GC is of interest because its relevance to the mechanisms of transport for distribution of a variety of materials -plankton, contaminants, microalgae, etc.- and its association with areas of sedimentary deposits, zones where there is a higher probability for fishing or related to the presence of certain species of marine life. Recent studies explain the circulation of the GC as a result of the Pacific Ocean's forcing, wind, heat fluxes on the sea surface and the interaction between the flow produced by these agents and bathymetry. The objective of this work was to obtain evidence of the patterns of surface circulation using a spatial resolution of 250 m over a period of two to seven days (depending on cloud cover), which offered images from the MODIS Level 1B. This essay is an attempt to contribute with more information to the understanding of the regional dynamics of the GC and its local influence on the zones bordering the coast. Thus, MODIS Aqua 250 m data was used, to which algorithms were applied in order to enhance the contrast of reflectance levels of these bands (0.620-0.670 and 0.841-0.876 µm) within the marine environment. The results are associated with suspended particulate matter (SPM), which we used as tracers of the surface circulation, using a sequence of images from January 2004 to December 2008. Algorithms for dust and cloud detection were used and incorporated with thermal band images, in which zones of terrigenous contribution by eolian transport were identified. Furthermore, pluvial

  10. Voltage balancing: Long-term experience with the 250 V supercapacitor module of the hybrid fuel cell vehicle HY-LIGHT

    Energy Technology Data Exchange (ETDEWEB)

    Koetz, R.; Sauter, J.-C.; Ruch, P.; Dietrich, P.; Buechi, F.N. [Paul Scherrer Institut, Electrochemistry Laboratory, CH-5232 Villigen PSI (Switzerland); Magne, P.A.; Varenne, P. [Conception et Developpement Michelin SA, CH-1762 Givisiez (Switzerland)

    2007-11-22

    On the occasion of the ''Challenge Bibendum'' 2004 in Shanghai, the hybrid fuel cell - supercapacitor vehicle HY-LIGHT, a joint project of Conception et Developpement Michelin and the Paul Scherrer Institut, was presented to the public. The drive train of this vehicle comprises a 30 kW polymer electrolyte fuel cell (PEFC) and a 250 V supercapacitor (SC) module for energy recuperation and boost power during short acceleration and start-up processes. The supercapacitor module was deliberately constructed without continuous voltage balancing units. The performance of the supercapacitor module was monitored over the 2 years of operation particularly with respect to voltage balancing of the large number of SC cells connected in series. During the investigated period of 19 months and about 7000 km driving, the voltage imbalance within the supercapacitor module proved negligible. The maximum deviation between best and worst SC was always below 120 mV and the capacitor with the highest voltage never exceeded the nominal voltage by more than 40 mV. (author)

  11. Efficient charge carrier injection into sub-250 nm AlGaN multiple quantum well light emitting diodes

    Energy Technology Data Exchange (ETDEWEB)

    Mehnke, Frank, E-mail: mehnke@physik.tu-berlin.de; Kuhn, Christian; Guttmann, Martin; Reich, Christoph; Kolbe, Tim; Rass, Jens; Wernicke, Tim [Technische Universität Berlin, Institut für Festkörperphysik, Hardenbergstr. 36, EW 6-1, 10623 Berlin (Germany); Kueller, Viola; Knauer, Arne; Lapeyrade, Mickael; Einfeldt, Sven; Weyers, Markus [Ferdinand-Braun-Institut, Leibniz-Institut für Höchstfrequenztechnik, Gustav-Kirchhoff-Str. 4, 12489 Berlin (Germany); Kneissl, Michael [Technische Universität Berlin, Institut für Festkörperphysik, Hardenbergstr. 36, EW 6-1, 10623 Berlin (Germany); Ferdinand-Braun-Institut, Leibniz-Institut für Höchstfrequenztechnik, Gustav-Kirchhoff-Str. 4, 12489 Berlin (Germany)

    2014-08-04

    The design and Mg-doping profile of AlN/Al{sub 0.7}Ga{sub 0.3}N electron blocking heterostructures (EBH) for AlGaN multiple quantum well (MQW) light emitting diodes (LEDs) emitting below 250 nm was investigated. By inserting an AlN electron blocking layer (EBL) into the EBH, we were able to increase the quantum well emission power and significantly reduce long wavelength parasitic luminescence. Furthermore, electron leakage was suppressed by optimizing the thickness of the AlN EBL while still maintaining sufficient hole injection. Ultraviolet (UV)-C LEDs with very low parasitic luminescence (7% of total emission power) and external quantum efficiencies of 0.19% at 246 nm have been realized. This concept was applied to AlGaN MQW LEDs emitting between 235 nm and 263 nm with external quantum efficiencies ranging from 0.002% to 0.93%. After processing, we were able to demonstrate an UV-C LED emitting at 234 nm with 14.5 μW integrated optical output power and an external quantum efficiency of 0.012% at 18.2 A/cm{sup 2}.

  12. Efficient charge carrier injection into sub-250 nm AlGaN multiple quantum well light emitting diodes

    International Nuclear Information System (INIS)

    Mehnke, Frank; Kuhn, Christian; Guttmann, Martin; Reich, Christoph; Kolbe, Tim; Rass, Jens; Wernicke, Tim; Kueller, Viola; Knauer, Arne; Lapeyrade, Mickael; Einfeldt, Sven; Weyers, Markus; Kneissl, Michael

    2014-01-01

    The design and Mg-doping profile of AlN/Al 0.7 Ga 0.3 N electron blocking heterostructures (EBH) for AlGaN multiple quantum well (MQW) light emitting diodes (LEDs) emitting below 250 nm was investigated. By inserting an AlN electron blocking layer (EBL) into the EBH, we were able to increase the quantum well emission power and significantly reduce long wavelength parasitic luminescence. Furthermore, electron leakage was suppressed by optimizing the thickness of the AlN EBL while still maintaining sufficient hole injection. Ultraviolet (UV)-C LEDs with very low parasitic luminescence (7% of total emission power) and external quantum efficiencies of 0.19% at 246 nm have been realized. This concept was applied to AlGaN MQW LEDs emitting between 235 nm and 263 nm with external quantum efficiencies ranging from 0.002% to 0.93%. After processing, we were able to demonstrate an UV-C LED emitting at 234 nm with 14.5 μW integrated optical output power and an external quantum efficiency of 0.012% at 18.2 A/cm 2

  13. STUDY ON DISCHARGE HEAT UTILIZATION OF 250 MWe PCMSR TURBINE SYSTEM FOR DESALINATION USING MODIFIED MED

    Directory of Open Access Journals (Sweden)

    Andang Widiharto

    2015-03-01

    Full Text Available PCMSR (Passive Compact Molten Salt Reactor is one type of Advanced Nuclear Reactors. The PCMSR has benefit charasteristics of very efficient fuel use, high safety charecteristic as well as high thermodinamics efficiency. This is due to its breeding capability, inherently safe characteristic and totally passive safety system. The PCMSR design consists of three module, i.e. reactor module, turbine module and fuel management module. Analysis in performed by parametric calculation of the turbine system to calculate the turbine system efficiency and the hat available for desalination. After that the mass and energi balance of desalination process are calculated to calculate the amount of distillate produced and the amount of feed sea water needed. The turbine module is designed to be operated at maximum temperature cycle of 1373 K (1200 0C and minimum temperature cycle of 333 K (60 0K. The parametric calculation shows that the optimum turbine pressure ratio is 4.3 that gives the conversion efficiency of 56 % for 4 stages turbine and 4 stages compressor and equiped with recuperator. In this optimum condition, the 250 MWe PCMSR turbine system produces 196 MWth of waste heat with the temperature of cooling fluid in the range from 327 K (54 0C to 368 K (92 0C. This waste heat can be utilized for desalination. By using MMED desalination system, this waste heat can be used to produce fresh water (distillate from sea water feed. The amount of the destillate produced is 48663 ton per day by using 15 distillation effects. The performance ratio value is 2.8727 kg/MJ by using 15 distillation effects. Keywords: PCMSR, discharged heat, MMED desalination   PCMSR (Passive Compact Molten Salt Reactor merupakan salah satu tipe dari Reaktor Nuklir Maju. PCMSR memiliki keuntungan berupa penggunaan bahan bakar yang sangat efisisien, sifat keselamatan tinggi dan sekaligus efisiensi termodinamika yang tinggi. Hal ini disebabkan oleh kemampuan pembiakan bahan bakar, sifat

  14. Optical simulations for the S3 project - Super separator spectrometer - gamma-electron coincidence spectroscopy of a transfermium nucleus: the 251Md101

    International Nuclear Information System (INIS)

    Dechery, Fabien

    2012-01-01

    In analogy with the atomic closed shells giving rise to the stability and high ionisation energies of noble gases, nuclear physics also has its magic numbers of protons and neutrons which enhance nuclear structure stability. Knowledge of the structure of doubly-magic nuclei, both proton and neutron numbers, is crucial to parameterize theoretical models. The discovery of the next and ultimate magic numbers will provide a strong constraint on the many predictions. These two numbers are like the centre coordinates of an area of enhanced stability of the nuclear chart, well known as 'island of stability'. These superheavy nuclei only exist due to pure quantum shell effects. My thesis work deals with two distinct, but complementary, aspects of fundamental physics with the common goal of studying these extreme mass nuclei structure. The first part corresponds to the development of a next generation instrument for nuclear physics to allow synthesis and spectroscopy studies of superheavy nuclei: the Super Separator Spectrometer S 3 . This project will be installed at SPIRAL2 (GANIL) and has been approved by the French Research National Agency (ANR) within the EQUIPEX framework. It has been designed to take advantage of the high intensity heavy ion beam from the LINAC, giving access to a wide range of physical programs. The second part corresponds to the preparation, realisation and analysis of an experiment on 251-Mendelevium in which the very first prompt gamma-electron coincidence spectroscopy was performed for a transfermium nuclei. (author) [fr

  15. Staining of proteins in gels with Coomassie G-250 without organic solvent and acetic acid.

    Science.gov (United States)

    Lawrence, Ann-Marie; Besir, H Uuml Seyin

    2009-08-14

    In classical protein staining protocols using Coomassie Brilliant Blue (CBB), solutions with high contents of toxic and flammable organic solvents (Methanol, Ethanol or 2-Propanol) and acetic acid are used for fixation, staining and destaining of proteins in a gel after SDS-PAGE. To speed up the procedure, heating the staining solution in the microwave oven for a short time is frequently used. This usually results in evaporation of toxic or hazardous Methanol, Ethanol or 2-Propanol and a strong smell of acetic acid in the lab which should be avoided due to safety considerations. In a protocol originally published in two patent applications by E.M. Wondrak (US2001046709 (A1), US6319720 (B1)), an alternative composition of the staining solution is described in which no organic solvent or acid is used. The CBB is dissolved in bidistilled water (60-80 mg of CBB G-250 per liter) and 35 mM HCl is added as the only other compound in the staining solution. The CBB staining of the gel is done after SDS-PAGE and thorough washing of the gel in bidistilled water. By heating the gel during the washing and staining steps, the process can be finished faster and no toxic or hazardous compounds are evaporating. The staining of proteins occurs already within 1 minute after heating the gel in staining solution and is fully developed after 15-30 min with a slightly blue background that is destained completely by prolonged washing of the stained gel in bidistilled water, without affecting the stained protein bands.

  16. Determination of Hydrogen Diffusion Coefficients in Fused Silica From 23 to 250°C Using Raman Spectroscopy

    Science.gov (United States)

    Shang, L.; Chou, I.; Lu, W.; Burruss, R. C.

    2008-12-01

    The oxygen buffer technique is routinely used in experimental studies of redox sensitive geochemical reactions at elevated pressures (P) and temperatures (T). However, this technique is limited to T above about 400°C due to the low permeability of sample containers (Pt or Ag-Pd alloys) to hydrogen at lower T. Preliminary results of Chou et al. (Geochim. Cosmochim. Acta, 2008, doi:10.1016/j.gca.2008.07.030) indicate that the use of fused silica capillary (FSC) container may extend this technique to lower T. In this study, hydrogen diffusion coefficients (D) in FSC were determined from 23 to 250°C by measuring the loss of hydrogen from the FSC containers (0.3 mm OD, 0.1 mm ID, and ~10 mm long) with Raman spectroscopy using CO2 as an internal standard. First, CO2 was loaded cryogenically in a FSC capsule (Chou et al., ibid.). The capsule was then inserted in a protective ceramic tube, sealed in a gold capsule containing Fe powder and water, and heated at 300°C under 100 MPa of Ar external P in a cold-seal pressure vessel for several days allowing H2 to diffuse into the capsule. After quench, the Raman spectra were collected and the initial relative concentration of hydrogen in the silica capsule was derived from the peak height ratios between H2 (near 587 cm-1) and CO2 (near 1387 cm- 1). The sample capsule was then heated at a fixed T at one atmosphere to let H2 diffuse out of the capsule, and the changes of hydrogen concentration were monitored by Raman spectroscopy after quench. This process was repeated with different heating durations at 23 (room T), 50, 102, 157, 200, and 250°C. The values of D (in cm2s-1) in FSC were obtained by fitting the observed changes of hydrogen concentration to an equation based on Fick's second law. Our results can be represented by: Ln D (±0.14) = (-39810/RT) - 9.5491 (r2 = 0.9985) where R is the gas constant, and T in Kelvin. The slope corresponds to an activation energy of 39.81 kJ/mol. Our D values are about a half order of

  17. Three novel variants (p.Glu178Lys, p.Val245Met, p.Ser250Phe) of the phenylalanine hydroxylase (PAH) gene impair protein expression and function in vitro.

    Science.gov (United States)

    Zong, Yanan; Liu, Ning; Ma, Shanshan; Bai, Ying; Guan, Fangxia; Kong, Xiangdong

    2018-08-20

    Phenylketonuria (PKU) is the most common inherited metabolic disease, an autosomal recessive disorder affecting >10,000 newborns each year globally. It can be caused by over 1000 different naturally occurring mutations in the phenylalanine hydroxylase (PAH) gene. We analyzed three novel naturally occurring PAH gene variants: p.Glu178Lys (c.532G>A), p.Val245Met (c.733G>A) and p.Ser250Phe (c.749C>T). The mutant effect on the PAH enzyme structure and function was predicted by bioinformatics software. Vectors expressing the corresponding PAH variants were generated for expression in E. coli and in HEK293T cells. The RNA expression of the three PAH variants was measured by quantitative reverse transcription polymerase chain reaction (RT-qPCR). The mutant PAH protein levels were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), western blot and enzyme-linked immunosorbent assay (ELISA). All three variants were predicted to be pathogenic by bioinformatics analysis. The transcription of the three PAH variants was similar to the wild type PAH gene in HEK293T cells. In contrast, the levels of mutant PAH proteins decreased significantly compared to the wild type control, in both E. coli and HEK293T cells. Our results indicate that the three novel PAH gene variants (p.Glu178Lys, p.Val245Met, p.Ser250Phe) impair PAH protein expression and function in prokaryotic and eukaryotic cells. Copyright © 2018. Published by Elsevier B.V.

  18. Hydrological variability in the Northern Levant: a 250 ka multiproxy record from the Yammoûneh (Lebanon) sedimentary sequence

    Science.gov (United States)

    Gasse, F.; Vidal, L.; Develle, A.-L.; van Campo, E.

    2011-11-01

    The Levant is a key region in terms of both long-term hydroclimate dynamics and human cultural evolution. Our understanding of the regional response to glacial-interglacial boundary conditions is limited by uncertainties in proxy-data interpretation and the lack of long-term records from different geographical settings. The present paper provides a 250 ka paleoenvironmental reconstruction based on a multi-proxy approach from northern Levant, derived from a 36 m lacustrine-palustrine sequence cored in the small intra-mountainous karstic Yammoûneh basin from northern Lebanon. We combined time series of sediment properties, paleovegetation, and carbonate oxygen isotopes (δc), to yield a comprehensive view of paleohydrologic-paleoclimatic fluctuations in the basin over the two last glacial-interglacial cycles. Integration of all available proxies shows that Interglacial maxima (early-mid MIS 7, MIS 5.5 and early MIS 1) experienced relatively high effective moisture, evidenced by the dominance of forested landscapes (although with different forest types) associated with authigenic carbonate sedimentation in a productive waterbody. Synchronous and steep δc increases can be reconciled with enhanced mean annual moisture when changes in seasonality are taken into account. During Glacials periods (MIS 2 and MIS 6), open vegetation tends to replace the forests, favouring local erosion and detrital sedimentation. However, all proxy data reveal an overall wetting during MIS 6, while a drying trend took place during MIS4-2, leading to extremely harsh LGM conditions possibly linked to water storage as ice in the surrounding highlands. Over the past 250 ka, the Yammoûneh record shows an overall decrease in local effective water, coincident with a weakening of seasonal insolation contrasts linked to the decreasing amplitude of the eccentricity cycle. The Yammoûneh record is roughly consistent with long-term climatic fluctuations in the northeastern Mediterranean region (except

  19. Hydrological variability in the Northern Levant: a 250 ka multiproxy record from the Yammoûneh (Lebanon sedimentary sequence

    Directory of Open Access Journals (Sweden)

    F. Gasse

    2011-11-01

    Full Text Available The Levant is a key region in terms of both long-term hydroclimate dynamics and human cultural evolution. Our understanding of the regional response to glacial-interglacial boundary conditions is limited by uncertainties in proxy-data interpretation and the lack of long-term records from different geographical settings.

    The present paper provides a 250 ka paleoenvironmental reconstruction based on a multi-proxy approach from northern Levant, derived from a 36 m lacustrine-palustrine sequence cored in the small intra-mountainous karstic Yammoûneh basin from northern Lebanon. We combined time series of sediment properties, paleovegetation, and carbonate oxygen isotopes (δc, to yield a comprehensive view of paleohydrologic-paleoclimatic fluctuations in the basin over the two last glacial-interglacial cycles. Integration of all available proxies shows that Interglacial maxima (early-mid MIS 7, MIS 5.5 and early MIS 1 experienced relatively high effective moisture, evidenced by the dominance of forested landscapes (although with different forest types associated with authigenic carbonate sedimentation in a productive waterbody. Synchronous and steep δc increases can be reconciled with enhanced mean annual moisture when changes in seasonality are taken into account. During Glacials periods (MIS 2 and MIS 6, open vegetation tends to replace the forests, favouring local erosion and detrital sedimentation. However, all proxy data reveal an overall wetting during MIS 6, while a drying trend took place during MIS4-2, leading to extremely harsh LGM conditions possibly linked to water storage as ice in the surrounding highlands. Over the past 250 ka, the Yammoûneh record shows an overall decrease in local effective water, coincident with a weakening of seasonal insolation contrasts linked to the decreasing amplitude of the eccentricity cycle.

    The Yammoûneh record is roughly consistent with long-term climatic

  20. Sixteen years of agricultural drought assessment of the BioBío region in Chile using a 250 m resolution Vegetation Condition Index (VCI)

    Science.gov (United States)

    Zambrano, Francisco; Lillo-Saavedra, Mario; Verbist, Koen; Lagos, Octavio

    2016-10-01

    Drought is one of the most complex natural hazards because of its slow onset and long-term impact; it has the potential to negatively affect many people. There are several advantages to using remote sensing to monitor drought, especially in developing countries with limited historical meteorological records and a low weather station density. In the present study, we assessed agricultural drought in the croplands of the BioBio Region in Chile. The vegetation condition index (VCI) allows identifying the temporal and spatial variations of vegetation conditions associated with stress because of rainfall deficit. The VCI was derived at a 250m spatial resolution for the 2000-2015 period with the Moderate Resolution Imaging Spectroradiometer (MODIS) MOD13Q1 product. We evaluated VCI for cropland areas using the land cover MCD12Q1 version 5.1 product and compared it to the in situ Standardized Precipitation Index (SPI) for six-time scales (1-6 months) from 26 weather stations. Results showed that the 3-month SPI (SPI-3), calculated for the modified growing season (Nov-Apr) instead of the regular growing season (Sept-Apr), has the best Pearson correlation with VCI values with an overall correlation of 0.63 and between 0.40 and 0.78 for the administrative units. These results show a very short-term vegetation response to rainfall deficit in September, which is reflected in the vegetation in November, and also explains to a large degree the variation in vegetation stress. It is shown that for the last 16 years in the BioBio Region we could identify the 2007/2008, 2008/2009, and 2014/2015 seasons as the three most important drought events; this is reflected in both the overall regional and administrative unit analyses. These results concur with drought emergencies declared by the regional government. Future studies are needed to associate the remote sensing values observed at high resolution (250m) with the measured crop yield to identify more detailed individual crop

  1. Redox behaviour of vanadium during hydrogen-oxygen exposure of the V2O5-WO3/TiO2 SCR catalyst at 250 degrees C

    DEFF Research Database (Denmark)

    Due-Hansen, Johannes; Rasmussen, Søren B.; Mikolajska, Ewelina

    2011-01-01

    of H-2 (0-2%) in an 8% O-2/N-2 mixture, where the SCR activity was measured before and after the hydrogen treatment. The results show that the activity of the SCR catalyst is only negligibly affected during exposure to the H-2/O-2 gas and in all cases it returned reversibly to the initial NOx...... conversion rate after reexposure to the standard NH3-SCR gas. In situ electron paramagnetic resonance (EPR) and UV-vis spectroscopy at 250 degrees C suggest that a significant part of V4+ present during SCR conditions was oxidized to V5+ during exposure to 2% H-2 + 8% O-2. However, the distribution...

  2. Mechanism of Coomassie Brilliant Blue G-250 binding to cetyltrimethylammonium bromide: an interference with the Bradford assay.

    Science.gov (United States)

    Aminian, Mahdi; Nabatchian, Fariba; Vaisi-Raygani, Asad; Torabi, Mojgan

    2013-03-15

    The Bradford protein assay is a popular method because of its rapidity, sensitivity, and relative specificity. This method is subject to some interference by nonprotein compounds. In this study, we describe the interference of cetyltrimethylammonium bromide (CTAB) with the Bradford assay. This interference is based on the interaction of Coomassie Brilliant Blue G-250 (CBB) with this cationic detergent. This study suggests that both electrostatic and hydrophobic interactions are involved in the interaction of CTAB and CBB. The anionic and neutral forms of CBB bind to CTAB by electrostatic attraction, which accelerates hydrophobic interactions of these CBB forms and the hydrophobic tail of CTAB. Consequently, the hydrophobic regions of the dominant free cationic form of CBB dye compete for the tail of CTAB with two other forms of the dye and gradually displace the primary hydrophobic interactions and rearrange the primary CBB-CTAB complex. This interaction of CTAB and CBB dye produces a primary 650-nm-absorbing complex that then gradually rearranges to a complex that shows an absorbance shoulder at 800-950 nm. This study conclusively shows a strong response of CBB to CTAB that causes a time-dependent and nearly additive interference with the Bradford assay. This study also may promote an application of CBB for CTAB quantification. Copyright © 2012 Elsevier Inc. All rights reserved.

  3. Dahiri, Mohammed; Carmelo García, Juan; González, Santiago; Lozano, Carlos; Otega, Alejandra y Thieux, Laurence (eds., Sociedad civil y transiciones en el norte de África. Egipto, Túnez, Argelia, Marruecos. Barcelona, Icaria Editorial, 2013, 250 pp.

    Directory of Open Access Journals (Sweden)

    Antonio Javier Martín Castellanos

    2014-10-01

    Full Text Available Dahiri, Mohammed; Carmelo García, Juan; González, Santiago; Lozano, Carlos; Otega, Alejandra y Thieux, Laurence (eds., Sociedad civil y transiciones en el norte de África. Egipto, Túnez, Argelia, Marruecos. Barcelona, Icaria Editorial, 2013, 250 pp.

  4. Discovery of abundant cellulose microfibers encased in 250 Ma Permian halite: a macromolecular target in the search for life on other planets.

    Science.gov (United States)

    Griffith, Jack D; Willcox, Smaranda; Powers, Dennis W; Nelson, Roger; Baxter, Bonnie K

    2008-04-01

    In this study, we utilized transmission electron microscopy to examine the contents of fluid inclusions in halite (NaCl) and solid halite crystals collected 650 m below the surface from the Late Permian Salado Formation in southeastern New Mexico (USA). The halite has been isolated from contaminating groundwater since deposition approximately 250 Ma ago. We show that abundant cellulose microfibers are present in the halite and appear remarkably intact. The cellulose is in the form of 5 nm microfibers as well as composite ropes and mats, and was identified by resistance to 0.5 N NaOH treatment and susceptibility to cellulase enzyme treatment. These cellulose microfibers represent the oldest native biological macromolecules to have been directly isolated, examined biochemically, and visualized (without growth or replication) to date. This discovery points to cellulose as an ideal macromolecular target in the search for life on other planets in our Solar System.

  5. Reconstructions of Fire Activity in North America and Europe over the Past 250 Years: A comparison of the Global Charcoal Database with Historical Records

    Science.gov (United States)

    Magi, B. I.; Marlon, J. R.; Mouillot, F.; Daniau, A. L.; Bartlein, P. J.; Schaefer, A.

    2017-12-01

    Fire is intertwined with climate variability and human activities in terms of both its causes and consequences, and the most complete understanding will require a multidisciplinary approach. The focus in this study is to compare data-based records of variability in climate and human activities, with fire and land cover change records over the past 250 years in North America and Europe. The past 250 years is a critical period for contextualizing the present-day impact of human activities on climate. Data are from the Global Charcoal Database and from historical reconstructions of past burning. The GCD is comprised of sediment records of charcoal accumulation rates collected around the world by dozens of researchers, and facilitated by the PAGES Global Paleofire Working Group. The historical reconstruction extends back to 1750 CE is based on literature and government records when available, and completed with non-charcoal proxies including tree ring scars or storylines when data are missing. The key data sets are independent records, and the methods and results are independent of any climate or fire-model simulations. Results are presented for Europe, and subsets of North America. Analysis of fire trends from GCD and the historical reconstruction shows broad agreement, with some regional variations as expected. Western USA and North America in general show the best agreement, with departures in the GCD and historical reconstruction fire trends in the present day that may reflect limits in the data itself. Eastern North America shows agreement with an increase in fire from 1750 to 1900, and a strong decreasing trend thereafter. We present ideas for why the trends agree and disagree relative to historical events, and to the sequence of land-cover change in the regions of interest. Together with careful consideration of uncertainties in the data, these results can be used to constrain Earth System Model simulations of both past fire, which explicitly incorporate

  6. Design, fabrication, commissioning, and testing of a 250 g/s, 2-K helium cold compressor system

    International Nuclear Information System (INIS)

    V. Ganni; D. M. Arenius; B. S. Bevins; W. C. Chronis; J. D. Creel; J. D. Wilson Jr.

    2002-01-01

    In June 1999 the Thomas Jefferson National Accelerator Facility (TJNAF) Cryogenic Systems Group had completed the design, fabrication, and commissioning of a cold compressor system capable of pumping 250 g/s of 2-K helium vapor to a pressure above 1 bar. The 2-K cold box consists of five stages of centrifugal variable speed compressors with LN2 cooled drive motors and magnetic bearings, a plate fin heat exchanger, and an LN2 shield system. The new 2-K cold box (referred to as the SCN) was built as a redundant system to an existing four stage cold compressor SCM cold box that was commissioned in May 1994. The SCN has been in continuous service supporting the facility experiments since commissioning. This system has achieved a significant improvement in the total 2-K refrigeration system capacity and stability and has substantially increased the operating envelope both in cold compressor flow and operating pressure range. This paper describes the cold box configuration and the experience s in the design, fabrication, commissioning and performance evaluation. The capacity of the system for various operating pressures (0.040 to 0.025 bar at the load corresponding to a total compressor pressure ratio of 28 to 54) is presented. An effort is made to characterize the components and their operating data over the tested range. This includes the return side pressure drop in the distribution system, the heat exchanger, and the cold compressor characteristics. The system design parameters and their effects on performance are outlined

  7. Statistics and scaling of turbulence in a spatially developing mixing layer at Reλ = 250

    KAUST Repository

    Attili, Antonio

    2012-03-21

    The turbulent flow originating from the interaction between two parallel streams with different velocities is studied by means of direct numerical simulation. Rather than the more common temporal evolving layer, a spatially evolving configuration, with perturbed laminar inlet conditions is considered. The streamwise evolution and the self-similar state of turbulence statistics are reported and compared to results available in the literature. The characteristics of the transitional region agree with those observed in other simulations and experiments of mixing layers originating from laminar inlets. The present results indicate that the transitional region depends strongly on the inlet flow. Conversely, the self-similar state of turbulent kinetic energy and dissipation agrees quantitatively with those in a temporal mixing layer developing from turbulent initial conditions [M. M. Rogers and R. D. Moser, “Direct simulation of a self-similar turbulent mixing layer,” Phys. Fluids6, 903 (1994)]. The statistical features of turbulence in the self-similar region have been analysed in terms of longitudinal velocity structure functions, and scaling exponents are estimated by applying the extended self-similarity concept. In the small scale range (60 < r/η < 250), the scaling exponents display the universal anomalous scaling observed in homogeneous isotropic turbulence. The hypothesis of isotropy recovery holds in the turbulent mixing layer despite the presence of strong shear and large-scale structures, independently of the means of turbulence generation. At larger scales (r/η > 400), the mean shear and large coherent structures result in a significant deviation from predictions based on homogeneous isotropic turbulence theory. In this second scaling range, the numerical values of the exponents agree quantitatively with those reported for a variety of other flows characterized by strong shear, such as boundary layers, as well as channel and wake flows.

  8. Ultraviolet relaxation dynamics of aniline, N, N-dimethylaniline and 3,5-dimethylaniline at 250 nm

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, James O. F.; Saalbach, Lisa; Crane, Stuart W. [Institute of Photonics and Quantum Sciences, Heriot-Watt University, Edinburgh EH14 4AS (United Kingdom); Paterson, Martin J. [Institute of Chemical Sciences, Heriot-Watt University, Edinburgh EH14 4AS (United Kingdom); Townsend, Dave, E-mail: D.Townsend@hw.ac.uk [Institute of Photonics and Quantum Sciences, Heriot-Watt University, Edinburgh EH14 4AS (United Kingdom); Institute of Chemical Sciences, Heriot-Watt University, Edinburgh EH14 4AS (United Kingdom)

    2015-03-21

    Time-resolved photoelectron imaging was used to investigate the electronic relaxation dynamics of gas-phase aniline, N, N-dimethylaniline, and 3,5-dimethylaniline following ultraviolet excitation at 250 nm. Our analysis was supported by ab initio coupled-cluster calculations evaluating excited state energies and (in aniline) the evolution of a range of excited state physical properties as a function of N–H bond extension. Due to a lack of consistency between several earlier studies undertaken in aniline, the specific aim of this present work was to gain new insight into the previously proposed non-adiabatic coupling interaction between the two lowest lying singlet excited states S{sub 1}(ππ{sup ∗}) and S{sub 2}(3s/πσ{sup ∗}). The methyl-substituted systems N, N-dimethylaniline and 3,5-dimethylaniline were included in order to obtain more detailed dynamical information about the key internal molecular coordinates that drive the S{sub 1}(ππ{sup ∗})/S{sub 2}(3s/πσ{sup ∗}) coupling mechanism. Our findings suggest that in all three systems, both electronic states are directly populated during the initial excitation, with the S{sub 2}(3s/πσ{sup ∗}) state then potentially decaying via either direct dissociation along the N–X stretching coordinate (X = H or CH{sub 3}) or internal conversion to the S{sub 1}(ππ{sup ∗}) state. In aniline and N, N-dimethylaniline, both pathways most likely compete in the depletion of S{sub 2}(3s/πσ{sup ∗}) state population. However, in 3,5-dimethylaniline, only the direct dissociation mechanism appears to be active. This is rationalized in terms of changes in the relative rates of the two decay pathways upon methylation of the aromatic ring system.

  9. A 250 plastome phylogeny of the grass family (Poaceae): topological support under different data partitions

    Science.gov (United States)

    Burke, Sean V.; Wysocki, William P.; Clark, Lynn G.

    2018-01-01

    The systematics of grasses has advanced through applications of plastome phylogenomics, although studies have been largely limited to subfamilies or other subgroups of Poaceae. Here we present a plastome phylogenomic analysis of 250 complete plastomes (179 genera) sampled from 44 of the 52 tribes of Poaceae. Plastome sequences were determined from high throughput sequencing libraries and the assemblies represent over 28.7 Mbases of sequence data. Phylogenetic signal was characterized in 14 partitions, including (1) complete plastomes; (2) protein coding regions; (3) noncoding regions; and (4) three loci commonly used in single and multi-gene studies of grasses. Each of the four main partitions was further refined, alternatively including or excluding positively selected codons and also the gaps introduced by the alignment. All 76 protein coding plastome loci were found to be predominantly under purifying selection, but specific codons were found to be under positive selection in 65 loci. The loci that have been widely used in multi-gene phylogenetic studies had among the highest proportions of positively selected codons, suggesting caution in the interpretation of these earlier results. Plastome phylogenomic analyses confirmed the backbone topology for Poaceae with maximum bootstrap support (BP). Among the 14 analyses, 82 clades out of 309 resolved were maximally supported in all trees. Analyses of newly sequenced plastomes were in agreement with current classifications. Five of seven partitions in which alignment gaps were removed retrieved Panicoideae as sister to the remaining PACMAD subfamilies. Alternative topologies were recovered in trees from partitions that included alignment gaps. This suggests that ambiguities in aligning these uncertain regions might introduce a false signal. Resolution of these and other critical branch points in the phylogeny of Poaceae will help to better understand the selective forces that drove the radiation of the BOP and PACMAD

  10. Statistics and scaling of turbulence in a spatially developing mixing layer at Reλ = 250

    KAUST Repository

    Attili, Antonio; Bisetti, Fabrizio

    2012-01-01

    The turbulent flow originating from the interaction between two parallel streams with different velocities is studied by means of direct numerical simulation. Rather than the more common temporal evolving layer, a spatially evolving configuration, with perturbed laminar inlet conditions is considered. The streamwise evolution and the self-similar state of turbulence statistics are reported and compared to results available in the literature. The characteristics of the transitional region agree with those observed in other simulations and experiments of mixing layers originating from laminar inlets. The present results indicate that the transitional region depends strongly on the inlet flow. Conversely, the self-similar state of turbulent kinetic energy and dissipation agrees quantitatively with those in a temporal mixing layer developing from turbulent initial conditions [M. M. Rogers and R. D. Moser, “Direct simulation of a self-similar turbulent mixing layer,” Phys. Fluids6, 903 (1994)]. The statistical features of turbulence in the self-similar region have been analysed in terms of longitudinal velocity structure functions, and scaling exponents are estimated by applying the extended self-similarity concept. In the small scale range (60 < r/η < 250), the scaling exponents display the universal anomalous scaling observed in homogeneous isotropic turbulence. The hypothesis of isotropy recovery holds in the turbulent mixing layer despite the presence of strong shear and large-scale structures, independently of the means of turbulence generation. At larger scales (r/η > 400), the mean shear and large coherent structures result in a significant deviation from predictions based on homogeneous isotropic turbulence theory. In this second scaling range, the numerical values of the exponents agree quantitatively with those reported for a variety of other flows characterized by strong shear, such as boundary layers, as well as channel and wake flows.

  11. Production asymmetry of $\\Lambda^0$ and ${\\overline{\\Lambda}}^0$ in $\\pi^{\\pm}$, $K^{\\pm}$, p - nucleon collisions at 250 GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Nicola, Marcello Santo [Brazilian Center for Physics Research, Rio de Janeiro (Brazil)

    2001-02-01

    Using data from Fermilab xed-target experiment E769, we have measured particleantiparticle production asymmetries for Λ0 hyperons in π± - nucleon interactions, K ± - nucleon interactions and p - nucleon interactions at 250 GeV/c. The asymmetries are measured as functions of Feynman-x (xf ) and pT2 over the ranges 0 ≤ pT2 ≤ 4(GeV/c)2 and -0.12 ≤ xF ≤ 0.12 (for positive beam) and 0 ≤ pT2 ≤ 10(GeV/c)2 and -0.16 ≤ xF ≤ 0:.0 for the negative beam. We find substantial asymmetries, even at xF = 0. We also observe leading-particle-type asymmetries which qualitatively agree with theoretical predictions.

  12. Effect of 4-(N,N-diethylamino)benzaldehyde thiosemicarbazone on the corrosion of aged 18 Ni 250 grade maraging steel in phosphoric acid solution

    International Nuclear Information System (INIS)

    Poornima, T.; Nayak, Jagannath; Nityananda Shetty, A.

    2011-01-01

    Highlights: → DEABT as corrosion inhibitor for maraging steel in phosphoric acid. → Inhibition efficiency increases with increase in inhibitor concentration. → Inhibition efficiency decreases with increase in temperature. → Adsorption obeys Langmuir adsorption isotherm. - Abstract: 4-(N,N-diethylamino)benzaldehyde thiosemicarbazone (DEABT) was studied for its corrosion inhibition property on the corrosion of aged 18 Ni 250 grade maraging steel in 0.67 M phosphoric acid at 30-50 deg. C by potentiodynamic polarization, EIS and weight loss techniques. Inhibition efficiency of DEABT was found to increase with the increase in DEABT concentration and decrease with the increase in temperature. The activation energy E a and other thermodynamic parameters (ΔG ads 0 , ΔH ads 0 , ΔS ads 0 ) have been evaluated and discussed. The adsorption of DEABT on aged maraging steel surface obeys the Langmuir adsorption isotherm model and the inhibitor showed mixed type inhibition behavior.

  13. COOMET pilot comparison 473/RU-a/09: Comparison of hydrophone calibrations in the frequency range 250 Hz to 200 kHz

    Science.gov (United States)

    Yi, Chen; Isaev, A. E.; Yuebing, Wang; Enyakov, A. M.; Teng, Fei; Matveev, A. N.

    2011-01-01

    A description is given of the COOMET project 473/RU-a/09: a pilot comparison of hydrophone calibrations at frequencies from 250 Hz to 200 kHz between Hangzhou Applied Acoustics Research Institute (HAARI, China)—pilot laboratory—and Russian National Research Institute for Physicotechnical and Radio Engineering Measurements (VNIIFTRI, Designated Institute of Russia of the CIPM MRA). Two standard hydrophones, B&K 8104 and TC 4033, were calibrated and compared to assess the current state of hydrophone calibration of HAARI (China) and Russia. Three different calibration methods were applied: a vibrating column method, a free-field reciprocity method and a comparison method. The standard facilities of each laboratory were used, and three different sound fields were applied: pressure field, free-field and reverberant field. The maximum deviation of the sensitivities of two hydrophones between the participants' results was 0.36 dB. Main text. To reach the main text of this paper, click on Final Report. The final report has been peer-reviewed and approved for publication by the CCAUV-KCWG.

  14. Resistance of Incoloy 800 steam generator tube to pitting corrosion in PWR secondary water at 250°C

    International Nuclear Information System (INIS)

    Schvartzman, Mônica M.A.M.; Albuquerque, Adriana Silva de; Esteves, Luiza; Rabello, Emerson G.; Mansur, Fábio Abud

    2017-01-01

    The steam generator (SG) is one of the main components of a PWR, so the performance of this type of nuclear power plant depends to a large extent on the trouble-free operation of SGs. Its degradation significantly affects the overall plant performance. Alloy 800NG (Incoloy® 800) is a nickel-iron-chromium alloy used for steam generator tubes in PWRs due to their high strength, good workability and resistance to corrosion. This behavior is attributed to the protective oxide film formed on the metal surface by contact with the high temperature pressurized water. However, chloride is one of major SG impurities that cause the breakdown of the passive film and initiate localized corrosion in passive metals as Alloy 800NG. The aim of this study is to provide information about the pitting corrosion behavior of the Incoloy® 800 steam generator tube under normal secondary circuit parameters (250 deg C and 5 MPa) and abnormal conditions of operation (presence of chloride ions in the secondary water). For this, optical microscopy, XRD and EDS analysis and electrochemical tests have been carried out under simulated PWR secondary water operating conditions. The susceptibility to pitting corrosion was evaluated using electrochemical tests and the oxide layer formed on material was examined by means of scanning electron microscopy (SEM) and energy dispersive X-ray spectrometer (EDS) analyses. (author)

  15. Hydroclimatic variability in loess δDwax records from the central Chinese Loess Plateau over the past 250 ka

    Science.gov (United States)

    Wang, Zheng; An, Zhisheng; Liu, Zhonghui; Qiang, Xiaoke; Zhang, Fan; Liu, Weiguo

    2018-04-01

    This study reports hydrogen isotopic records from the central Chinese Loess Plateau (CLP) over the past 250 ka. After eliminating the influence of ice and local temperatures, the δDwax records extracted from two loess sites at Xifeng and Luochuan can be taken to represent arid/humid alternations in the hydrological environment in this marginal Asian Summer Monsoon (ASM) region; they also contain integrated information on summer precipitation patterns and the corresponding responses to these changes by predominant vegetation cover types. These arid/humid alternations show 100 ka, 40 ka and 20 ka cycles. An increase in precipitation in association with an enhanced summer monsoon has historically been taken to be the major factor driving a humid environment in the central CLP. However, hydroclimatic changes in δDwax records differ for the central CLP, central China and southern China. Over a 20 ka cycle, the influence of solar insolation on hydroclimatic changes can be shown to be consistent throughout the central CLP. However, changes in the relative location of the land and sea may have caused different hydroclimatic responses between southern China and the central CLP on a glacial-interglacial scale. The hydroclimatic variability in the central CLP would suggest that an enhanced summer monsoon due to climatic warming is the key to understanding decreased drought degree in this marginal monsoonal region.

  16. Detection of benign hilar bile duct stenoses - A retrospective analysis in 250 patients with suspicion of Klatskin tumour.

    Science.gov (United States)

    Scheuermann, Uwe; Widyaningsih, Rizky; Hoppe-Lotichius, Maria; Heise, Michael; Otto, Gerd

    2016-06-01

    The aim of this study was to identify clinical, laboratory and radiological parameters to distinguish benign from malignant stenoses of the proximal bile duct. Between 1997 and 2011, 250 patients were referred to our clinic with hilar bile duct stenoses suspicious for Klatskin tumour. Medical histories, clinical data, pre-interventional laboratory tests, imaging findings, as well as therapeutic approach and patient outcome were compared to final histological results. All data were retrieved from our prospectively maintained database and analysed retrospectively. We found benign bile duct lesions in 34 patients (13.6%). Among the entire study population, uni- and multivariate analyses of 18 clinicopathological parameters revealed that patient age, serum alkaline phosphatase, tumour marker CA19-9 and presence of tumour mass in computed tomography were independent predictors for malignant biliary stenoses (p hilar biliary stenoses of 74.6%, 80.0% and 83.5%, respectively. Surgical resection could be avoided by preoperative work-up and surgical exploration in 10 out of 34 patients with benign lesions. Rates of major liver resections performed were 66.7% in the benign lesion group and 90.7% in the Klatskin tumour group. Despite improvements of preoperative diagnostics, it remains difficult to differentiate between benign and malignant hilar bile duct stenosis. Even explorative laparotomy was not able to safely exclude Klatskin tumour in all cases and therefore major liver resection was inevitable.

  17. Resistance of Incoloy 800 steam generator tube to pitting corrosion in PWR secondary water at 250°C

    Energy Technology Data Exchange (ETDEWEB)

    Schvartzman, Mônica M.A.M. [Pontifícia Universidade Católica de Minas Gerais (PUC-Minas), Belo Horizonte, MG (Brazil); Albuquerque, Adriana Silva de; Esteves, Luiza; Rabello, Emerson G.; Mansur, Fábio Abud, E-mail: monicacdtn@gmail.com, E-mail: asa@cdtn.br, E-mail: luiza.esteves@cdtn.br, E-mail: egr@cdtn.br, E-mail: fametalurgica@gmail.com [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2017-07-01

    The steam generator (SG) is one of the main components of a PWR, so the performance of this type of nuclear power plant depends to a large extent on the trouble-free operation of SGs. Its degradation significantly affects the overall plant performance. Alloy 800NG (Incoloy® 800) is a nickel-iron-chromium alloy used for steam generator tubes in PWRs due to their high strength, good workability and resistance to corrosion. This behavior is attributed to the protective oxide film formed on the metal surface by contact with the high temperature pressurized water. However, chloride is one of major SG impurities that cause the breakdown of the passive film and initiate localized corrosion in passive metals as Alloy 800NG. The aim of this study is to provide information about the pitting corrosion behavior of the Incoloy® 800 steam generator tube under normal secondary circuit parameters (250 deg C and 5 MPa) and abnormal conditions of operation (presence of chloride ions in the secondary water). For this, optical microscopy, XRD and EDS analysis and electrochemical tests have been carried out under simulated PWR secondary water operating conditions. The susceptibility to pitting corrosion was evaluated using electrochemical tests and the oxide layer formed on material was examined by means of scanning electron microscopy (SEM) and energy dispersive X-ray spectrometer (EDS) analyses. (author)

  18. Calendar aging of a 250 kW/500 kWh Li-ion battery deployed for the grid storage application

    Science.gov (United States)

    Kubiak, Pierre; Cen, Zhaohui; López, Carmen M.; Belharouak, Ilias

    2017-12-01

    The introduction of Li-ion batteries for grid applications has become evidence as the cost per kWh is continuously decreasing. Although the Li-ion battery is a mature technology for automotive applications and portable electronics, its use for stationary applications needs more validation. The Li-ion technology is considered safe enough for grid storage application, but its lifetime is generally evaluated to be around 10 years. Higher market penetration will be achieved if a longer lifespan could be demonstrated. Therefore, aging evaluation of the batteries becomes crucial. In this paper we investigated the effects of aging after a three years' standby field deployment of a 250 kW/500 kWh Li-ion battery integrated with the grid and solar farm under the harsh climate conditions of Qatar. The development of tools for acquisition and analysis of data from the battery management system (BMS) allows the assessment of the battery performance at the battery stack, string and cell levels. The analysis of the residual capacity after aging showed that the stack suffered from a low decrease of capacity, whereas some inconsistencies have been found between the strings. These inconsistencies are caused by misalignment of a small number of cells that underwent self-discharge during standby at high state of charge.

  19. 250 ORIGINAL ARTICLE

    African Journals Online (AJOL)

    boaz

    vétérinaires ont été démontrées comme étant à risque de portage de Staphylococcus aureus résistant à la méticilline(SARM). ... antérieures ont été réalisées et ayant permisd'isolerdes S. aureus sur milieu culturechromogènique sélectif et la réalisation de ..... molecular characterization (mecA, femA) of our. MRSA strains to ...

  20. Guidance on the Use of Hand-Held Survey Meters for radiological Triage: Time-Dependent Detector Count Rates Corresponding to 50, 250, and 500 mSv Effective Dose for Adult Males and Adult Females

    International Nuclear Information System (INIS)

    Bolch, W.E.; Hurtado, J.L.; Lee, C.; Manger, Ryan P.; Hertel, Nolan; Burgett, E.; Dickerson, W.

    2012-01-01

    In June 2006, the Radiation Studies Branch of the Centers for Disease Control and Prevention held a workshop to explore rapid methods of facilitating radiological triage of large numbers of potentially contaminated individuals following detonation of a radiological dispersal device. Two options were discussed. The first was the use of traditional gamma cameras in nuclear medicine departments operated as makeshift wholebody counters. Guidance on this approach is currently available from the CDC. This approach would be feasible if a manageable number of individuals were involved, transportation to the relevant hospitals was quickly provided, and the medical staff at each facility had been previously trained in this non-traditional use of their radiopharmaceutical imaging devices. If, however, substantially larger numbers of individuals (100 s to 1,000 s) needed radiological screening, other options must be given to first responders, first receivers, and health physicists providing medical management. In this study, the second option of the workshop was investigated by the use of commercially available portable survey meters (either NaI or GM based) for assessing potential ranges of effective dose (G50, 50Y250, 250Y500, and 9500 mSv). Two hybrid computational phantoms were used to model an adult male and an adult female subject internally contaminated with 241Am, 60Cs, 137Cs, 131I, or 192Ir following an acute inhalation or ingestion intake. As a function of time following the exposure, the net count rates corresponding to committed effective doses of 50, 250, and 500 mSv were estimated via Monte Carlo radiation transport simulation for each of four different detector types, positions, and screening distances. Measured net count rates can be compared to these values, and an assignment of one of four possible effective dose ranges could be made. The method implicitly assumes that all external contamination has been removed prior to screening and that the measurements be

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