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  1. The role of genetic (PON1 polymorphism and environmental factors, especially physical activity, in antioxidant function of paraoxonase*

    Directory of Open Access Journals (Sweden)

    Aneta Otocka-Kmiecik

    2009-12-01

    Full Text Available Paraoxonase 1 ([i]PON1[/i] is a member of a three-gene family ([i]PON1, PON2[/i], and [i]PON3[/i]. PON1 activity dominates in human plasma. It is secreted from hepatic cells and is found in the circulation bound to high-density lipoproteins (HDLs. For many years it has been known only for its ability to hydrolyze organophosphate derivatives. More recently, PON1’s antioxidant activity draws attention as the enzyme was described to prevent oxidation of lipoproteins by reactive oxygen species formed during oxidative stress. PON1 was also shown to hydrolyze atherogenic products of oxidative lipid modification such as phospholipid peroxides and cholesterol ester hydroperoxides. Some studies indicate that the enzyme presents a lipolactonase activity and hydrolyzes homocysteine thiolactone (HCTL. There is growing evidence as to PON1’s protective role in atherosclerosis. Genetic (PON1 polymorphism and environmental factors and lifestyle may influence PON1 blood concentration and biological activity. Among the many recognized factors accounting for lifestyle, physical activity plays an important role. Various, often opposite, effects on PON1 status are observed in regular training and single physical activities. The results of different studies are often contradictory. It may depend on the time, intensity, and frequency of physical activity. Additionally, it seems that the effects of physical activity on [i]PON1[/i] blood concentration and activity are modified by environmental and lifestyle factors as well as [i]PON1[/i] polymorphism.

  2. Pig PON1

    DEFF Research Database (Denmark)

    Larsen, Knud Erik; Farajzadeh, Leila; Kristensen, Kaja Kjaer

    2018-01-01

    Atherosclerosis is an inflammatory disease promoted by oxidized low density lipoprotein (LDL). High density lipoprotein (HDL) is an important antioxidant, protecting LDL and itself from oxidation and by detoxifying the hydroperoxides from oxidized LDL. Paraoxonase, encoded by the PON1 gene......, is an enzyme involved in oxidant defense by hydrolyzing oxidized lipids, including oxLDL, and in detoxification of organophosphate pesticides. Aging is the major risk factor for developing atherosclerosis and as paraoxonase is responsible for the antioxidant effect of HDL, aging might be accompanied...

  3. Paraoxonase 2 (PON2) in the mouse central nervous system: A neuroprotective role?

    Energy Technology Data Exchange (ETDEWEB)

    Giordano, Gennaro [Dept. of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA (United States); Cole, Toby B. [Dept. of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA (United States); Dept. of Medicine (Div. of Medical Genetics), University of Washington, Seattle, WA (United States); Dept. of Genome Sciences, University of Washington, Seattle, WA (United States); Furlong, Clement E. [Dept. of Medicine (Div. of Medical Genetics), University of Washington, Seattle, WA (United States); Dept. of Genome Sciences, University of Washington, Seattle, WA (United States); Costa, Lucio G., E-mail: lgcosta@u.washington.edu [Dept. of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA (United States); Dept. of Human Anatomy, Pharmacology and Forensic Science, University of Parma Medical School, Parma (Italy)

    2011-11-15

    The aims of this study were to characterize the expression of paraoxonase 2 (PON2) in mouse brain and to assess its antioxidant properties. PON2 levels were highest in the lung, intestine, heart and liver, and lower in the brain; in all tissues, PON2 expression was higher in female than in male mice. PON2 knockout [PON2{sup -/-}] mice did not express any PON2, as expected. In the brain, the highest levels of PON2 were found in the substantia nigra, the nucleus accumbens and the striatum, with lower levels in the cerebral cortex, hippocampus, cerebellum and brainstem. A similar regional distribution of PON2 activity (measured by dihydrocoumarin hydrolysis) was also found. PON3 was not detected in any brain area, while PON1 was expressed at very low levels, and did not show any regional difference. PON2 levels were higher in astrocytes than in neurons isolated from all brain regions, and were highest in cells from the striatum. PON2 activity and mRNA levels followed a similar pattern. Brain PON2 levels were highest around birth, and gradually declined. Subcellular distribution experiments indicated that PON2 is primarily expressed in microsomes and in mitochondria. The toxicity in neurons and astrocytes of agents known to cause oxidative stress (DMNQ and H{sub 2}O{sub 2}) was higher in cells from PON2{sup -/-} mice than in the same cells from wild-type mice, despite similar glutathione levels. These results indicate that PON2 is expressed in the brain, and that higher levels are found in dopaminergic regions such as the striatum, suggesting that this enzyme may provide protection against oxidative stress-mediated neurotoxicity.

  4. Paraoxonase 2 (PON2) in the mouse central nervous system: A neuroprotective role?

    International Nuclear Information System (INIS)

    Giordano, Gennaro; Cole, Toby B.; Furlong, Clement E.; Costa, Lucio G.

    2011-01-01

    The aims of this study were to characterize the expression of paraoxonase 2 (PON2) in mouse brain and to assess its antioxidant properties. PON2 levels were highest in the lung, intestine, heart and liver, and lower in the brain; in all tissues, PON2 expression was higher in female than in male mice. PON2 knockout [PON2 −/− ] mice did not express any PON2, as expected. In the brain, the highest levels of PON2 were found in the substantia nigra, the nucleus accumbens and the striatum, with lower levels in the cerebral cortex, hippocampus, cerebellum and brainstem. A similar regional distribution of PON2 activity (measured by dihydrocoumarin hydrolysis) was also found. PON3 was not detected in any brain area, while PON1 was expressed at very low levels, and did not show any regional difference. PON2 levels were higher in astrocytes than in neurons isolated from all brain regions, and were highest in cells from the striatum. PON2 activity and mRNA levels followed a similar pattern. Brain PON2 levels were highest around birth, and gradually declined. Subcellular distribution experiments indicated that PON2 is primarily expressed in microsomes and in mitochondria. The toxicity in neurons and astrocytes of agents known to cause oxidative stress (DMNQ and H 2 O 2 ) was higher in cells from PON2 −/− mice than in the same cells from wild-type mice, despite similar glutathione levels. These results indicate that PON2 is expressed in the brain, and that higher levels are found in dopaminergic regions such as the striatum, suggesting that this enzyme may provide protection against oxidative stress-mediated neurotoxicity.

  5. PON1 and Mediterranean Diet

    Directory of Open Access Journals (Sweden)

    José M. Lou-Bonafonte

    2015-05-01

    Full Text Available The Mediterranean diet has been proven to be highly effective in the prevention of cardiovascular diseases. Paraoxonase 1 (PON1 has been implicated in the development of those conditions, especially atherosclerosis. The present work describes a systematic review of current evidence supporting the influence of Mediterranean diet and its constituents on this enzyme. Despite the differential response of some genetic polymorphisms, the Mediterranean diet has been shown to exert a protective action on this enzyme. Extra virgin olive oil, the main source of fat, has been particularly effective in increasing PON1 activity, an action that could be due to low saturated fatty acid intake, oleic acid enrichment of phospholipids present in high-density lipoproteins that favor the activity, and increasing hepatic PON1 mRNA and protein expressions induced by minor components present in this oil. Other Mediterranean diet constituents, such as nuts, fruits and vegetables, have been effective in modulating the activity of the enzyme, pomegranate and its compounds being the best characterized items. Ongoing research on compounds isolated from all these natural products, mainly phenolic compounds and carotenoids, indicates that some of them are particularly effective, and this may enhance the use of nutraceuticals and functional foods capable of potentiating PON1 activity.

  6. Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus

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    Manzi Susan

    2011-01-01

    Full Text Available Abstract Background Low serum paraoxonase (PON activity is associated with the risk of coronary artery disease, diabetes and systemic lupus erythematosus (SLE. Our prior studies have shown that the PON1/rs662 (p.Gln192Arg, PON1/rs854560 (p.Leu55Met, PON3/rs17884563 and PON3/rs740264 SNPs (single nucleotide polymorphisms significantly affect serum PON activity. Since PON1, PON2 and PON3 share high degree of structural and functional properties, in this study, we examined the role of PON2 genetic variation on serum PON activity, risk of SLE and SLE-related clinical manifestations in a Caucasian case-control sample. Methods PON2 SNPs were selected from HapMap and SeattleSNPs databases by including at least one tagSNP from each bin defined in these resources. A total of nineteen PON2 SNPs were successfully genotyped in 411 SLE cases and 511 healthy controls using pyrosequencing, restriction fragment length polymorphism (RFLP or TaqMan allelic discrimination methods. Results Our pair-wise linkage disequilibrium (LD analysis, using an r2 cutoff of 0.7, identified 14 PON2 tagSNPs that captured all 19 PON2 variants in our sample, 12 of which were not in high LD with known PON1 and PON3 SNP modifiers of PON activity. Stepwise regression analysis of PON activity, including the known modifiers, identified five PON2 SNPs [rs6954345 (p.Ser311Cys, rs13306702, rs987539, rs11982486, and rs4729189; P = 0.005 to 2.1 × 10-6] that were significantly associated with PON activity. We found no association of PON2 SNPs with SLE risk but modest associations were observed with lupus nephritis (rs11981433, rs17876205, rs17876183 and immunologic disorder (rs11981433 in SLE patients (P = 0.013 to 0.042. Conclusions Our data indicate that PON2 genetic variants significantly affect variation in serum PON activity and have modest effects on risk of lupus nephritis and SLE-related immunologic disorder.

  7. Paraoxonase 1 (PON1) status and substrate hydrolysis

    International Nuclear Information System (INIS)

    Richter, Rebecca J.; Jarvik, Gail P.; Furlong, Clement E.

    2009-01-01

    Paraoxonase 1 (PON1) hydrolyzes a number of organophosphorus (OP) compounds including insecticides and nerve agents. The in vivo efficacy of PON1 to protect against a specific OP exposure depends on the catalytic efficiency of hydrolysis. The Q192R polymorphism affects the catalytic efficiency of hydrolysis of some substrates and not others. While PON1 R192 hydrolyzes paraoxon approximately 9-times as efficiently as PON1 Q192 , the efficiency is insufficient to provide in vivo protection against paraoxon/parathion exposure. The two PON1 192 alloforms have nearly equivalent but higher catalytic efficiencies for hydrolyzing diazoxon (DZO) and provide equivalent in vivo protection against DZO exposures. On the other hand, PON1 R192 is significantly more efficient in hydrolyzing chlorpyrifos oxon (CPO) than PON1 Q192 and provides better protection against CPO exposure. Thus, for some exposures it is only the level of plasma PON1 that is important, whereas for others it is both plasma level and the PON1 192 alloform(s) present in plasma that are important. In no case is the plasma level of PON1 unimportant, provided that the catalytic efficiency is sufficient to protect against the exposure. Two-substrate enzyme assay/analysis protocols that reveal both PON1 plasma levels and PON1 192 phenotype (QQ; QR; RR) are designed to optimize the separation of PON1 192 phenotypes; however, they have not been optimized for evaluating in vivo rates of OP detoxication. This study describes the adaptation of a non-OP, two-substrate determination of PON1 status to the conversion of the PON1 status data to physiologically relevant rates of DZO and CPO detoxication. Conversion factors were generated for rates of hydrolysis of different substrates

  8. An Engineered Version of Human PON2 Opens the Way to Understand the Role of Its Post-Translational Modifications in Modulating Catalytic Activity.

    Directory of Open Access Journals (Sweden)

    Luigi Mandrich

    Full Text Available The human paraoxonase 2 (PON2 has been described as a highly specific lactonase hydrolysing the quorum sensing molecule N-(3-oxododecanoyl-L-homoserine lactone (3OC12-HSL and having secondary esterase but not phosphotriesterase activity, in contrast with the related enzymes PON1 and PON3. It has been suggested that PON2 enzyme activity is dependent on glycosylation and its N-terminal region has been recently demonstrated to be a transmembrane domain mediating association to membranes. In the present study we describe a mutated form of PON2, lacking the above N-terminal region, which has been further stabilized by the insertion of six amino acidic substitutions. The engineered version, hence forth called rPON2, has been over-expressed in E.coli, refolded from inclusion bodies and purified, yielding an enzyme with the same characteristics as the full length enzyme. Therefore the first conclusion of this work was that the catalytic activity is independent from the N-terminus and protein glycosylation. The kinetic characterization confirmed the primary activity on 3OC12-HSL; accordingly, in vitro experiments of inhibition of the biofilm formed by Pseudomonas aeruginosa (PAO1 have demonstrated that rPON2 is more effective than PON1. In addition, we observed small but significant activity against organophosphorothiotes pesticides, m-parathion, coumaphos and malathion.The availability of fair amount of active protein allowed to pinpoint, by mass-spectrometry, ubiquitination of Lys 168 induced in rPON2 by HeLa extract and to correlate such post-translational modification to the modulation of catalytic activity. A mutational analysis of the modified residue confirmed the result.

  9. Effect of moxifloxacin on oxidative stress, paraoxonase-1 (PON1 ...

    African Journals Online (AJOL)

    Purpose: To investigate the effect of moxifloxacin on paraoxonase-1 (PON1) activity, and serum oxidative stress in patients with multiple drug-resistant tuberculosis (MDR-TB). Methods: A total ofof 130 MDR-TB patients who were treated with moxifloxacin from October 2014 to October 2010 in Eastern Medical District of Linyi ...

  10. Photonic integrated transmitter and receiver for NG-PON2

    Science.gov (United States)

    Tavares, Ana; Lopes, Ana; Rodrigues, Cláudio; Mãocheia, Paulo; Mendes, Tiago; Brandão, Simão.; Rodrigues, Francisco; Ferreira, Ricardo; Teixeira, António

    2014-08-01

    In this paper the authors present a monolithic Photonic Integrated Circuit which includes a transmitter and a receiver for NG-PON2. With this layout it is possible to build an OLT and, by redesigning some filters, also an ONU. This technology allows reducing the losses in the transmitter and in the receiver, increasing power budget, and also reducing the OEO conversions, which has been a major problem that operators want to surpass.

  11. Role of paraoxonase 1 (PON1) in organophosphate metabolism: Implications in neurodegenerative diseases

    Energy Technology Data Exchange (ETDEWEB)

    Androutsopoulos, Vasilis P. [Center of Toxicology Science and Research, University of Crete, Heraklion, Crete (Greece); Kanavouras, Konstantinos [Laboratory of Neurological Sciences, University of Crete, Heraklion, Crete (Greece); Tsatsakis, Aristidis M., E-mail: aris@med.uoc.gr [Center of Toxicology Science and Research, University of Crete, Heraklion, Crete (Greece)

    2011-11-15

    Organophosphate pesticides are a class of compounds that are widely used in agricultural and rural areas. Paraoxonase 1 (PON1) is a phase-I enzyme that is involved in the hydrolysis of organophosphate esters. Environmental poisoning by organophosphate compounds has been the main driving force of previous research on PON1 enzymes. Recent discoveries in animal models have revealed the important role of the enzyme in lipid metabolism. However although PON1 function is well established in experimental models, the contribution of PON1 in neurodegenerative diseases remains unclear. In this minireview we summarize the involvement of PON1 genotypes in the occurrence of Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis. A brief overview of latest epidemiological studies, regarding the two most important PON1 coding region polymorphisms PON1-L55M and PON1-Q192R is presented. Positive and negative associations of PON1 with disease occurrence are reported. Notably the MM and RR alleles contribute a risk enhancing effect for the development of some neurodegenerative diseases, which may be explained by the reduced lipoprotein free radical scavenging activity that may give rise to neuronal damage, through distinct mechanism. Conflicting findings that fail to support this postulate may represent the human population ethnic heterogeneity, different sample size and environmental parameters affecting PON1 status. We conclude that further epidemiological studies are required in order to address the exact contribution of PON1 genome in combination with organophosphate exposure in populations with neurodegenerative diseases.

  12. Role of paraoxonase 1 (PON1) in organophosphate metabolism: Implications in neurodegenerative diseases

    International Nuclear Information System (INIS)

    Androutsopoulos, Vasilis P.; Kanavouras, Konstantinos; Tsatsakis, Aristidis M.

    2011-01-01

    Organophosphate pesticides are a class of compounds that are widely used in agricultural and rural areas. Paraoxonase 1 (PON1) is a phase-I enzyme that is involved in the hydrolysis of organophosphate esters. Environmental poisoning by organophosphate compounds has been the main driving force of previous research on PON1 enzymes. Recent discoveries in animal models have revealed the important role of the enzyme in lipid metabolism. However although PON1 function is well established in experimental models, the contribution of PON1 in neurodegenerative diseases remains unclear. In this minireview we summarize the involvement of PON1 genotypes in the occurrence of Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis. A brief overview of latest epidemiological studies, regarding the two most important PON1 coding region polymorphisms PON1-L55M and PON1-Q192R is presented. Positive and negative associations of PON1 with disease occurrence are reported. Notably the MM and RR alleles contribute a risk enhancing effect for the development of some neurodegenerative diseases, which may be explained by the reduced lipoprotein free radical scavenging activity that may give rise to neuronal damage, through distinct mechanism. Conflicting findings that fail to support this postulate may represent the human population ethnic heterogeneity, different sample size and environmental parameters affecting PON1 status. We conclude that further epidemiological studies are required in order to address the exact contribution of PON1 genome in combination with organophosphate exposure in populations with neurodegenerative diseases.

  13. Genetic polymorphisms and activity of PON1 in a Mexican population

    International Nuclear Information System (INIS)

    Rojas-Garcia, A.E.; Solis-Heredia, M.J.; Pina-Guzman, B.; Vega, L.; Lopez-Carrillo, L.; Quintanilla-Vega, B.

    2005-01-01

    Human paraoxonase (PON1) plays a role in detoxification of organophosphorus (OP) compounds by hydrolyzing the bioactive oxons, and in reducing oxidative low-density lipoproteins, which may protect against atherosclerosis. Some PON1 polymorphisms have been found to be responsible for variations in catalytic activity and expression and have been associated with susceptibility to OP poisoning and vascular diseases. Both situations are of public health relevance in Mexico. Therefore, the aim of this study was to evaluate PON1 phenotype and the frequencies of polymorphisms PON1 -162, -108, 55, and 192 in a Mexican population. The studied population consisted of unrelated individuals (n = 214) of either gender, 18-52 years old. Serum PON1 activity was assayed using phenylacetate and paraoxon as substrates. PON1 variants, -162, 55, and 192, were determined by real-time PCR using the TaqMan System, and PON1 -108 genotype by PCR-RFLP. We found a wide interindividual variability of PON1 activity with a unimodal distribution; the range of enzymatic activity toward phenylacetate was 84.72 to 422.0 U/mL, and 88.37 to 1645.6 U/L toward paraoxon. All four PON1 polymorphisms showed strong linkage disequilibrium (D% >90). PON1 polymorphisms -108, 55, and 192 were independently associated with arylesterase activity; whereas the activity toward paraoxon was related only with PON1 192 polymorphism, suggesting that this polymorphism is determinant to infer PON1 activity. A better understanding of the phenotype and genotypes of PON1 in Mexican populations will facilitate further epidemiological studies involving PON1 variability in OP poisoning and in the development of atherosclerosis

  14. PON1 promoter polymorphisms contribute to PCOS susceptibility and phenotypic outcomes in Indian women.

    Science.gov (United States)

    Dadachanji, Roshan; Shaikh, Nuzhat; Patil, Anushree; Shah, Nalini; Mukherjee, Srabani

    2018-06-30

    Polycystic ovary syndrome is a common endocrinopathy characterized by anovulatory infertility, hyperandrogenism, insulin resistance and oxidative stress, which predisposes affected women to reproductive and cardiometabolic complications in later life. We have investigated the association of PON1 promoter polymorphisms with PCOS susceptibility, PON1 activity and its related traits in Indian women. The genotypic and allelic frequency distribution of only -907G/C polymorphism in PON1 promoter showed significant difference between non-hyperandrogenic control and PCOS women, and was significantly associated with reduced susceptibility to PCOS, considering the recessive model. PON1 lactonase and arylesterase activities were also significantly decreased in women with PCOS compared to controls. Further, PON1 promoter polymorphisms were linked to altered insulin and testosterone levels in hyperandrogenic and non-hyperandrogenic women with PCOS. This study highlights PON1 as an important candidate gene influencing genetic pathophysiology of PCOS. Copyright © 2018 Elsevier B.V. All rights reserved.

  15. PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos

    International Nuclear Information System (INIS)

    Ellison, Corie A.; Crane, Alice L.; Bonner, Matthew R.; Knaak, James B.; Browne, Richard W.; Lein, Pamela J.; Olson, James R.

    2012-01-01

    Animal studies have shown that paraoxonase 1 (PON1) genotype can influence susceptibility to the organophosphorus pesticide chlorpyrifos (CPF). However, Monte Carlo analysis suggests that PON1 genotype may not affect CPF-related toxicity at low exposure conditions in humans. The current study sought to determine the influence of PON1 genotype on the activity of blood cholinesterase as well as the effect of CPF exposure on serum PON1 in workers occupationally exposed to CPF. Saliva, blood and urine were collected from agricultural workers (n = 120) from Egypt's Menoufia Governorate to determine PON1 genotype, blood cholinesterase activity, serum PON1 activity towards chlorpyrifos-oxon (CPOase) and paraoxon (POase), and urinary levels of the CPF metabolite 3,5,6-trichloro-2-pyridinol (TCPy). The PON1 55 (P ≤ 0.05) but not the PON1 192 genotype had a significant effect on CPOase activity. However, both the PON1 55 (P ≤ 0.05) and PON1 192 (P ≤ 0.001) genotypes had a significant effect on POase activity. Workers had significantly inhibited AChE and BuChE after CPF application; however, neither CPOase activity nor POase activity was associated with ChE depression when adjusted for CPF exposure (as determined by urinary TCPy levels) and stratified by PON1 genotype. CPOase and POase activity were also generally unaffected by CPF exposure although there were alterations in activity within specific genotype groups. Together, these results suggest that workers retained the capacity to detoxify chlorpyrifos-oxon under the exposure conditions experienced by this study population regardless of PON1 genotype and activity and that effects of CPF exposure on PON1 activity are minimal. -- Highlights: ► CPF exposure resulted in an increase in TCPy and decreases in BuChE and AChE. ► CPOase activity decreased in subjects with the PON1 55LM and PON1 55 MM genotypes. ► Neither PON1 genotype nor CPOase activity had an effect on BuChE or AChE inhibition.

  16. PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos

    Energy Technology Data Exchange (ETDEWEB)

    Ellison, Corie A., E-mail: cellison@buffalo.edu [Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214 (United States); Crane, Alice L., E-mail: alcrane@buffalo.edu [Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214 (United States); Bonner, Matthew R., E-mail: mrbonner@buffalo.edu [Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, NY 14214 (United States); Knaak, James B., E-mail: jbknaak@aol.com [Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214 (United States); Browne, Richard W., E-mail: rwbrowne@buffalo.edu [Department of Biotechnical and Clinical Laboratory Sciences, State University of New York at Buffalo, Buffalo, NY 14214 (United States); Lein, Pamela J., E-mail: pjlein@ucdavis.edu [Department of Molecular Biosciences, University of California School of Veterinary Medicine, Davis, CA 95618 (United States); Olson, James R., E-mail: jolson@buffalo.edu [Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214 (United States); Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, NY 14214 (United States)

    2012-12-15

    Animal studies have shown that paraoxonase 1 (PON1) genotype can influence susceptibility to the organophosphorus pesticide chlorpyrifos (CPF). However, Monte Carlo analysis suggests that PON1 genotype may not affect CPF-related toxicity at low exposure conditions in humans. The current study sought to determine the influence of PON1 genotype on the activity of blood cholinesterase as well as the effect of CPF exposure on serum PON1 in workers occupationally exposed to CPF. Saliva, blood and urine were collected from agricultural workers (n = 120) from Egypt's Menoufia Governorate to determine PON1 genotype, blood cholinesterase activity, serum PON1 activity towards chlorpyrifos-oxon (CPOase) and paraoxon (POase), and urinary levels of the CPF metabolite 3,5,6-trichloro-2-pyridinol (TCPy). The PON1 55 (P ≤ 0.05) but not the PON1 192 genotype had a significant effect on CPOase activity. However, both the PON1 55 (P ≤ 0.05) and PON1 192 (P ≤ 0.001) genotypes had a significant effect on POase activity. Workers had significantly inhibited AChE and BuChE after CPF application; however, neither CPOase activity nor POase activity was associated with ChE depression when adjusted for CPF exposure (as determined by urinary TCPy levels) and stratified by PON1 genotype. CPOase and POase activity were also generally unaffected by CPF exposure although there were alterations in activity within specific genotype groups. Together, these results suggest that workers retained the capacity to detoxify chlorpyrifos-oxon under the exposure conditions experienced by this study population regardless of PON1 genotype and activity and that effects of CPF exposure on PON1 activity are minimal. -- Highlights: ► CPF exposure resulted in an increase in TCPy and decreases in BuChE and AChE. ► CPOase activity decreased in subjects with the PON1 55LM and PON1 55 MM genotypes. ► Neither PON1 genotype nor CPOase activity had an effect on BuChE or AChE inhibition.

  17. The Escape of Sisyphus or What “Post NG-PON2” Should Do Apart from Neverending Capacity Upgrades

    Directory of Open Access Journals (Sweden)

    Martin Maier

    2014-03-01

    Full Text Available The primary design goal of (revolutionary NG-PON1&2 was the provisioning of an ever increasing capacity to cope with video-dominated traffic and handle the explosion of mobile data traffic by means of offloading. Recently, however, questions on the future of “post NG-PON2” have surfaced whether to shift its research focus to business and operation related aspects and move access technology into a substantially different direction than continued capacity upgrades. In fact, recent studies indicate that ultimately the major factor limiting the performance of 4G mobile networks is latency rather than capacity of the backhaul. In this paper, we review recently proposed low-latency techniques for NG-PONs that require architectural modifications at the remote node or distribution fiber level and highlight advanced network coding and real-time polling based low-latency techniques that can be implemented in software, enable NG-PONs to carry higher traffic loads and thereby extend their lifetime, and maintain the passive nature of existent optical distribution networks. Furthermore, we elaborate on emerging trends and open challenges for future post NG-PON2 research. To better understand their true potential, we put them into a wider non-technical and historical perspective leading up to a sustainable Third Industrial Revolution (TIR economy and its underlying Energy Internet.

  18. [Preparation and preliminary application of rabbit anti-human PON2 antibodies(paraoxonase-2)].

    Science.gov (United States)

    Chen, Miao; Yang, Jin-Ju; Li, Shu-Zhen; Liu, Xiao-Lan; Liu, Ying; Zhang, Lin-Jie; Gao, Jian-En; Sun, Qi-Hong

    2008-07-01

    To preparation and characterize the rabbit polyclonal antibodies against human PON2 (paraoxonase-2). A fragment of human PON2 gene which was of low homology with rabbits but of higher hydrophilicity and immunogenicity was selected for recombinant expression in prokaryotic expression system. The rabbits were immunized with the purified GST fusion protein 3 times. The specificity and sensitivity of the anti-human PON2 polyclonal antibodies were detected by Western blot and indirect immunofluorescence. The GST-PON2 fusion protein was highly expressed in Ecoli with a molecular weight of 46 kDa. Western blot analysis proved the rabbit polyclonal antibodies could specifically recognize 39 kDa native PON2 protein expressed in several cells and tissues, such as HeLa cells, U937 cells, and human liver tissue. Indirect immunofluorescence analysis confirmed that PON2 protein was located in the cytoplasm of SY5Y cells. The rabbit polyclonal antibodies against human PON2 can specifically recognize natural protein expressed in human cells and tissues, Which can be used for further study and clinical detection of human PON2.

  19. Interaction between organophosphate pesticide exposure and PON1 activity on thyroid function

    International Nuclear Information System (INIS)

    Lacasana, Marina; Lopez-Flores, Inmaculada; Rodriguez-Barranco, Miguel; Aguilar-Garduno, Clemente; Blanco-Munoz, Julia; Perez-Mendez, Oscar; Gamboa, Ricardo; Gonzalez-Alzaga, Beatriz; Bassol, Susana; Cebrian, Mariano E.

    2010-01-01

    Organophosphate pesticides are widely used in agricultural purposes. Recently, a few studies have demonstrated the ability of these chemicals to alter the function of the thyroid gland in human. Moreover, the paraoxonase-1 enzyme (PON1) plays an important role in the toxicity of some organophosphate pesticides, with low PON1 activity being associated with higher pesticide sensitivity. This study evaluates the interaction between exposure to organophosphate compounds and PON1 enzyme activity on serum levels of TSH and thyroid hormones in a population of workers occupationally exposed to pesticides. A longitudinal study was conducted on a population of floriculture workers from Mexico, during two periods of high and low-intensity levels of pesticide application. A structured questionnaire was completed by workers containing questions on sociodemographic characteristics and other variables of interest. Urine and blood samples were taken, and biomarkers of exposure (dialkylphosphates), susceptibility (PON1 polymorphisms and activity) and effect (thyroid hormone levels) were determined. Interaction between dialkylphosphates and PON1 polymorphisms or PON1 activity on hormone levels was evaluated by generalized estimating equation (GEE) models. A significant interaction was found between serum diazoxonase activity and total dialkylphosphates (ΣDAP) on TSH levels. Thus, when PON1 activity was increased we observed a decrease in the percentage of variation of TSH level for each increment in one logarithmic unit of the ΣDAP levels. This interaction was also observed with the PON1 192 RR genotype. These results suggest a stronger association between organophosphate pesticides and thyroid function in individuals with lower PON1 activity.

  20. Relationship between human paraoxonase-1 activity and PON1 polymorphisms in Mexican workers exposed to organophosphate pesticides.

    Science.gov (United States)

    López-Flores, I; Lacasaña, M; Blanco-Muñoz, J; Aguilar-Garduño, C; Sanchez-Villegas, P; Pérez-Méndez, O A; Gamboa-Avila, R

    2009-07-24

    Paraoxonase-1 (PON1) is a serum enzyme which catalyzes the hydrolysis of organophosphate pesticides. In this study we conducted a cross-sectional study and reported on the distribution of three common genetic polymorphisms of the PON1 gene in a population of floriculture workers from Mexico as well as the association between those polymorphisms and other predictors with serum PON1 activity on paraoxon, diazoxon and phenylacetate. The genotype frequencies at position PON1(55) were 89% (LL), 10% (LM) and 0.6% (MM), at position PON1(192) they were 16% (QQ), 47% (QR) and 37% (RR), and 26% (TT), 42% (TC) and 32% (CC) at position PON1(-108). Thus, the frequencies of alleles L, Q and T were 0.94, 0.40 and 0.47, respectively. The PON1(55) polymorphism had no significant effect on serum PON1 activity on any substrate. We found a significant association between the PON1(192) polymorphism and PON1 activity towards paraoxon and diazoxon, which increased in genotypes as follows: 192RR>192QR>192QQ for paraoxonase activity and, inversely, 192QQ>192QR>192RR for diazoxonase activity. The PON1(-108) polymorphism also had a significant effect on PON1 activity level towards paraoxon in the following order among the genotype groups: -108CC>-108TC>-108TT. Serum PON1 activity towards diazoxon was not associated with the PON1(-108) polymorphism but it was influenced by the intensity exposure to pesticides at the floriculture industry and the years of the occupational exposure to pesticides. No polymorphism significantly influenced serum PON1 activity on phenylacetate.

  1. PON1 polymorphisms are associated with polycystic ovary syndrome susceptibility, related traits, and PON1 activity in Indian women with the syndrome.

    Science.gov (United States)

    Dadachanji, Roshan; Shaikh, Nuzhat; Khavale, Sushma; Patil, Anushree; Shah, Nalini; Mukherjee, Srabani

    2015-07-01

    To investigate the association of paraoxonase 1 (PON1) polymorphisms (L55M and Q192R) with polycystic ovary syndrome (PCOS) susceptibility and its related traits in Indian women. Case-control study. Academic research institute, infertility, and endocrinology clinics. Controls (n = 326), women with PCOS (n = 482). None. Genotypic and allelic frequency distribution, genotype-phenotype association, different PON1 activities (lactonase, arylesterase, and paraoxonase). The genotypic and allelic frequency distributions of the L55M polymorphism were significantly different between lean controls and lean women with PCOS, and this polymorphism reduced the risk of PCOS development in lean but not in obese Indian women. Furthermore, this polymorphism was significantly associated with decreased 2-hour glucose, apolipoprotein B, free and bioavailable T, and free androgen index concurrent with increased sex hormone-binding globulin (SHBG) and FSH levels only in lean women with PCOS. However, Q192R polymorphism showed comparable genotypic frequency distribution between controls and women with PCOS. PON1 lactonase and arylesterase activities were significantly decreased in women with PCOS compared with controls. PON1 polymorphisms were shown to influence its activities. Our study showed that L55M, but not Q192R, polymorphism is significantly associated with reduced PCOS susceptibility only in lean women and also impacts glucose metabolism, lipid parameters, and hyperandrogenemia in them. Our study therefore suggests the possibility of differential genetic pathophysiology of PCOS between lean and obese women. Copyright © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  2. Longitudinal changes in PON1 enzymatic activities in Mexican-American mothers and children with different genotypes and haplotypes

    International Nuclear Information System (INIS)

    Huen, Karen; Harley, Kim; Bradman, Asa; Eskenazi, Brenda; Holland, Nina

    2010-01-01

    The paraoxonase 1 (PON1) enzyme prevents low-density lipoprotein oxidation and also detoxifies the oxon derivatives of certain neurotoxic organophosphate (OP) pesticides. PON1 activity in infants is low compared to adults, rendering them with lower metabolic and antioxidant capacities. We made a longitudinal comparison of the role of genetic variability on control of PON1 phenotypes in Mexican-American mothers and their children at the time of delivery (n = 388 and 338, respectively) and again 7 years later (n = 280 and 281, respectively) using generalized estimating equations models. At age 7, children's mean PON1 activities were still lower than those of mothers. This difference was larger in children with genotypes associated with low PON1 activities (PON1 -108TT , PON1 192QQ , and PON1 -909CC ). In mothers, PON1 activities were elevated at delivery and during pregnancy compared to 7 years later when they were not pregnant (p < 0.001). In non-pregnant mothers, PON1 polymorphisms and haplotypes accounted for almost 2-fold more variation of arylesterase (AREase) and chlorpyrifos-oxonase (CPOase) activity than in mothers at delivery. In both mothers and children, the five PON1 polymorphisms (192, 55, -108, -909, -162) explained a noticeably larger proportion of variance of paraoxonase activity (62-78%) than AREase activity (12.3-26.6%). Genetic control of PON1 enzymatic activity varies in children compared to adults and is also affected by pregnancy status. In addition to known PON1 polymorphisms, unidentified environmental, genetic, or epigenetic factors may also influence variability of PON1 expression and therefore susceptibility to OPs and oxidative stress.

  3. Paraoxonase (PON1 and PON3 polymorphisms: impact on liver expression and atorvastatin-lactone hydrolysis

    Directory of Open Access Journals (Sweden)

    Stephan eRiedmaier

    2011-07-01

    Full Text Available Atorvastatin δ-lactone, a major, pharmacologically inactive metabolite, has been associated with toxicity. In a previous study we showed that polymorphisms of UGT1A3 influence atorvastatin δ-lactone formation. Here we investigated the reverse reaction, atorvastatin δ-lactone hydrolysis, in a human liver bank. Screening of microarray data revealed paraoxonases PON1 and PON3 among 17 candidate esterases. Microsomal δ-lactone hydrolysis was significantly correlated to PON1 and PON3 protein (rs=0.60; rs=0.62, respectively; P<0.0001. PON1 and PON3 were strongly correlated to each other (rs=0.60 but PON1 was shown to be more extensively glycosylated than PON3. In addition a novel splice variant of PON3 was identified. Genotyping of 40 polymorphisms within the PON-locus identified PON1 promoter polymorphisms (-108T>C, -832G>A, -1741G>A and a tightly linked group of PON3 polymorphisms (-4984A>G, -4105G>A, -1091A>G, -746C>T and F21F to be associated with changes in atorvastatin δ-lactone hydrolysis and expression of PON1 but not PON3. However, carriers of the common PON1 polymorphisms L55M or Q192R showed no difference in δ-lactone hydrolysis or PON expression. Haplotype analysis revealed decreased δ-lactone hydrolysis in carriers of the most common haplotype *1 compared to carriers of haplotypes *2, *3, *4 and *7. Analysis of non-genetic factors showed association of hepatocellular and cholangiocellular carcinoma with decreased PON1 and PON3 expression, respectively. Increased C-reactive protein and γ-glutamyl transferase levels were associated with decreased protein expression of both enzymes, and increased bilirubin levels, cholestasis and pre-surgical exposure to omeprazole or pantoprazole were related to decreased PON3 protein. In conclusion, PON-locus polymorphisms affect PON1 expression whereas non-genetic factors have an effect on PON1 and PON3 expression. This may influence response to therapy or adverse events in statin treatment.

  4. Association between PON1 genetic polymorphisms and miscarriage in Mexican women exposed to pesticides.

    Science.gov (United States)

    Blanco-Muñoz, Julia; Aguilar-Garduño, Clemente; Gamboa-Avila, Ricardo; Rodríguez-Barranco, Miguel; Pérez-Méndez, Oscar; Huesca-Gómez, Claudia; González-Alzaga, Beatriz; Lacasaña, Marina

    2013-04-01

    Placental oxidative stress has been involved in the pathogenesis of certain reproductive adverse effects, including miscarriage. Paraxonase 1 (PON1) is a high-density lipoprotein(HDL)-linked enzyme that prevents oxidation of low-density lipoproteins (LDL) and is involved in detoxification from organophosphate pesticides. To assess the association between maternal PON1 polymorphisms (PON1192Q/R, PON155 L/M y PON1-108C/T) and the risk of miscarriage in women chronically exposed to organophosphate pesticides in Mexico. In a cross-sectional study, socio-demographic data, reproductive history data, environmental exposures, and other variables of concern were collected by means of a questionnaire from 264 women (floriculturists and wives of floriculturists) who had been pregnant sometime during the 10 years preceding the study. Blood samples were also collected from them. PON1192 and PON155 genotypes were determined by PCR amplification, and PON1-108 genotypes, by a TaqMan real-time polymerase chain reaction assay. Complete information regarding the results of pregnancy and maternal genotype tests was obtained for 514 pregnancies (35 miscarriages and 479 controls). The association between PON1 genotypes and miscarriage was evaluate through GEE models. The risk of miscarriage by mothers with PON1192RR genotype was 2.2 higher than by mothers with PON1192QR/PON1192QQ genotype (95% CI 0.93-5.17). The risk was close to 4 times higher in mothers with PON155MM/PON155LM genotype than in mothers with PON155LL genotype (OR=3.9; 95% CI 1.38-11.0). No significant differences were found in risk of miscarriage based on the maternal PON1-108C/T genotype. No evidence was found of an interaction between the various PON1 genotypes and the mothers' floricultural activity during pregnancy. This study suggests that there is an effect of genetic maternal PON1 polymorphisms on miscarriage and provides additional evidence that combines with the growing information about the ways in which

  5. Purification of PON1 from human serum and assessment of enzyme kinetics against metal toxicity.

    Science.gov (United States)

    Ekinci, Deniz; Beydemir, Sükrü

    2010-06-01

    Paraoxonase-1 (PON1) is an organophosphate hydrolyser enzyme which has also antioxidant properties in metabolism. Due to its crucial functions, inhibition of the enzyme is undesirable and very dangerous. PON1 enzyme activity should not be altered in any case. Inhibitory investigations of this enzyme are therefore important and useful. Metal toxicology of enzymes has become popular in the recent years. Here, we report the in vitro inhibitory effects of some metal ions, including Pb(+2), Cr(+2), Fe(+2), and Zn(+2), on the activity of human serum PON1 (hPON1; EC 3.1.8.1.). For this purpose, we purified the enzyme from human serum and analyzed the alterations in the enzyme activity in the presence of metal ions. The results show that metal ions exhibit inhibitory effects on hPON1 at low concentrations with IC (50) values ranging from 0.838 to 7.410 mM. Metal ions showed different inhibition mechanisms: lead and iron were competitive, chrome was noncompetitive, and zinc was uncompetitive. Lead was determined to be the most effective inhibitor.

  6. Distribution of PON1 polymorphisms PON1Q192R and PON1L55M among Chinese, Malay and Indian males in Singapore and possible susceptibility to organophosphate exposure.

    Science.gov (United States)

    Chia, Sin Eng; Mohamed Ali, Safiyya; Yap, Peng Huat Eric; Gan, Linda; Ong, Yeong Bing; Chia, Kee Seng

    2009-03-01

    Organophosphate (OP)-containing pesticides are widely used worldwide for domestic and industrial purposes. Studies on acute and chronic exposure to OPs have revealed numerous health effects attributed mainly to acetylcholinesterase (AChE) inhibition. The enzyme human serum paraoxonase (PON1) is involved in the detoxification of OP compounds. PON1 polymorphisms have been shown to affect susceptibility to OP exposure. We studied the effect of OP exposure on pest control workers and assessed the distribution of two common PON1 polymorphisms in our local population. The exposed group consisted of 103 workers from various pest control companies under the Singapore Pest Management Association while the 91 unexposed workers were from a lead stabilizer factory. For all workers, the mean age was 36.9 (20-70) years and the ethnic distribution was 38.1% Chinese, 44.3% Malay and 17.5% Indian. The mean+/-S.D. exposure duration among the pesticide workers was 10.4+/-8.4 years. The mean+/-S.D. RBC cholinesterase level was 18436.2+/-2078U/L and 18079.6+/-1576U/L for the exposed and unexposed groups, respectively (p=0.216). The mean+/-S.D. serum pseudocholinesterase was 11028.4+/-2867.4U/L and 9433.6+/-2022.6U/L in the exposed and unexposed groups, respectively (pChinese and Malays (266.5 and 266.3U/L, respectively) whereas that of the Indians was significantly lower (165.6U/L). Our study showed that cholinesterase levels among the exposed were not lower than those in the unexposed group. PON1 polymorphisms differed among ethnic groups, implying that ethnicity could be an important surrogate for identifying susceptible groups in case of OP exposure. Although OP poisoning is rare among occupationally exposed workers in Singapore, this information is useful for other developing countries that have large populations of Chinese, Malays and Indians where OP exposure could be very high especially in agricultural settings.

  7. Association of genetic polymorphisms of PON1 and CETP with the ...

    African Journals Online (AJOL)

    ... with an increased risk of cardiovascular disease and type 2 diabetes. PON1 and CETP genes may be involved in the pathogenesis of lipid metabolism and thus MetS. Several single nucleotide polymorphisms of genes were demonstrated to affect their function. Curcumin (diferuloylmethane) is a yellow pigment of turmeric ...

  8. Comparison of Bit Error Rate of Line Codes in NG-PON2

    Directory of Open Access Journals (Sweden)

    Tomas Horvath

    2016-05-01

    Full Text Available This article focuses on simulation and comparison of line codes NRZ (Non Return to Zero, RZ (Return to Zero and Miller’s code for NG-PON2 (Next-Generation Passive Optical Network Stage 2 using. Our article provides solutions with Q-factor, BER (Bit Error Rate, and bandwidth comparison. Line codes are the most important part of communication over the optical fibre. The main role of these codes is digital signal representation. NG-PON2 networks use optical fibres for communication that is the reason why OptSim v5.2 is used for simulation.

  9. Paraoxonase (PON)-1 activity in overweight and obese children and adolescents: association with obesity-related inflammation and oxidative stress

    NARCIS (Netherlands)

    Krzystek-Korpacka, Małgorzata; Patryn, Eliza; Hotowy, Katarzyna; Czapińska, Elżbieta; Majda, Jacek; Kustrzeba-Wójcicka, Irena; Noczyńska, Anna; Gamian, Andrzej

    2013-01-01

    Paraoxonase-1 (PON1) is a HDL-attached extracellular esterase which is believed to contribute to the anti-atherogenic and anti-inflammatory properties of HDL. A decrease in PON1 is a risk factor for cardiovascular disease and has recently been found to be associated with juvenile obesity. The issue

  10. Transduced PEP-1-PON1 proteins regulate microglial activation and dopaminergic neuronal death in a Parkinson's disease model.

    Science.gov (United States)

    Kim, Mi Jin; Park, Meeyoung; Kim, Dae Won; Shin, Min Jea; Son, Ora; Jo, Hyo Sang; Yeo, Hyeon Ji; Cho, Su Bin; Park, Jung Hwan; Lee, Chi Hern; Kim, Duk-Soo; Kwon, Oh-Shin; Kim, Joon; Han, Kyu Hyung; Park, Jinseu; Eum, Won Sik; Choi, Soo Young

    2015-09-01

    Parkinson's disease (PD) is an oxidative stress-mediated neurodegenerative disorder caused by selective dopaminergic neuronal death in the midbrain substantia nigra. Paraoxonase 1 (PON1) is a potent inhibitor of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) against oxidation by destroying biologically active phospholipids with potential protective effects against oxidative stress-induced inflammatory disorders. In a previous study, we constructed protein transduction domain (PTD) fusion PEP-1-PON1 protein to transduce PON1 into cells and tissue. In this study, we examined the role of transduced PEP-1-PON1 protein in repressing oxidative stress-mediated inflammatory response in microglial BV2 cells after exposure to lipopolysaccharide (LPS). Moreover, we identified the functions of transduced PEP-1-PON1 proteins which include, mitigating mitochondrial damage, decreasing reactive oxidative species (ROS) production, matrix metalloproteinase-9 (MMP-9) expression and protecting against 1-methyl-4-phenylpyridinium (MPP(+))-induced neurotoxicity in SH-SY5Y cells. Furthermore, transduced PEP-1-PON1 protein reduced MMP-9 expression and protected against dopaminergic neuronal cell death in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice model. Taken together, these results suggest a promising therapeutic application of PEP-1-PON1 proteins against PD and other inflammation and oxidative stress-related neuronal diseases. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. Oxidative status and serum PON1 activity in beta-thalassemia minor.

    Science.gov (United States)

    Selek, Sahbettin; Aslan, Mehmet; Horoz, Mehmet; Gur, Mustafa; Erel, Ozcan

    2007-03-01

    Paraoxonase-1 (PON1) deficiency is related to increased susceptibility to low density lipoprotein oxidation and development of atherosclerosis. The aim of this study was to investigate paraoxonase and arylesterase activities along with oxidative status parameters, and to find out if there is any increased susceptibility to atherogenesis, which might be reflected with increased oxidative stress and decreased serum PON1 activity in beta-thalassemia minor (BTM) subjects. Thirty-two subjects with BTM and 28 healthy subjects as control were enrolled in the study. Serum paraoxonase and arylesterase activities, lipid hydroperoxide (LOOH) levels, total antioxidant capacity (TAC), total oxidant status (TOS) and oxidative stress index (OSI) were determined. Serum TAC, paraoxonase and arylesterase activities were significantly lower in BTM subjects than controls (for all p<0.001), while TOS, LOOH levels and OSI were significantly higher (p<0.001, p<0.05 and p<0.001; respectively). In BTM subjects, OSI, TOS, LOOH levels and TAC were significantly correlated with serum paraoxonase (r=-0.245, p<0.05; r=-0.231, p<0.05; r=-0.264, p<0.05 and, r=0.342, p<0.05, respectively) and arylesterase activities (r=-0.332, p<0.05, r=-0.308, p<0.05; r=-0.320, p<0.05 and r=0.443, p<0.05). Additionally, hemoglobin level was also correlated with serum paraoxonase (r=0.501, p<0.001) and arylesterase activities (r=0.501, p<0.001), TAC (r=0.402, p<0.05), TOS (r=-0.274, p<0.05) and OSI (r=-0.352, p<0.05). Oxidative stress is increased, while serum PON1 activity is decreased in BTM subjects. Decrease in PON1 activity seems to be associated with both the degree of oxidative stress and anemia. BTM subjects may be more prone to development of atherogenesis due to low serum PON1 activity.

  12. Analysis of Coexisting GPON and NG-PON1 (10G-PON Systems

    Directory of Open Access Journals (Sweden)

    M. D. Mraković

    2011-06-01

    Full Text Available In this paper, the simulation model of coexisting GPON and NG-PON1 (10G-PON systems is presented, which has been developed for the analysis of feasibility and implementation issues of this coexistence. The aim was to analyze the impact of the most important parameters of the components that are needed for new network elements, on the performance of these coexistent networks. On the basis of the results obtained, the optimal parameters of the new system components were defined.

  13. Maternal exposure to floricultural work during pregnancy, PON1 Q192R polymorphisms and the risk of low birth weight

    Energy Technology Data Exchange (ETDEWEB)

    Moreno-Banda, G.; Blanco-Munoz, J. [Population Health Research Center, National Institute of Public Health, Avenida Universidad 655, Colonia Santa Maria Ahuacatitlan, 62508 Cuernavaca, Morelos (Mexico); Lacasana, M., E-mail: marina.lacasana.easp@juntadeandalucia.es [Andalusian School of Public Health, Campus Universitario de la Cartuja, Cuesta del Observatorio, 4, 18080 Granada (Spain); CIBER of Epidemiology and Public Health (CIBERESP) (Spain); Rothenberg, S.J. [Population Health Research Center, National Institute of Public Health, Avenida Universidad 655, Colonia Santa Maria Ahuacatitlan, 62508 Cuernavaca, Morelos (Mexico); Center of Research and Advanced Studies, National Institute Polytechnic, Department of Toxicology, Av, Instituto Politecnico Nacional No. 2508, Col. San Pedro Zacatenco, Deleg. Gustavo A. Madero, 07360 Mexico, D.F. (Mexico); Aguilar-Garduno, C. [Andalusian School of Public Health, Campus Universitario de la Cartuja, Cuesta del Observatorio, 4, 18080 Granada (Spain); Andalusian Observatory of Environmental Health, Campus Universitario de la Cartuja, Cuesta del Observatorio, 4, 18080 Granada (Spain); Gamboa, R. [Department of Physiology, National Institute of Cardiology ' Ignacio Chavez' , Juan Badiano 4, Section XVI, 14080, Mexico DF (Mexico); Perez-Mendez, O. [Department of Molecular Biology and cardiovascular Diseases Genomic and Proteomic, National Institute of Cardiology ' Ignacio Chavez' , Juan Badiano 4, Section XVI, 14080, Mexico DF (Mexico)

    2009-10-15

    Background: Although there is evidence from animal studies of impaired reproductive function by exposure to organophosphates (OP), the effects on birth weight have not been sufficiently evaluated in epidemiological studies. Paraoxonase (PON1) detoxifies organophosphates by cleavage of active oxons. Some PON1 gene polymorphisms could reduce the enzyme activity and increase susceptibility to OP toxicity. Objective: To assess the association between maternal exposure to floriculture during pregnancy and the risk of low birth weight (< 2500 g) in their offspring, as well as to evaluate the interaction between this exposure and maternal genotype for PON1 Q192R polymorphisms. Materials and methods: A cross sectional study was carried out in two Mexican states (States of Mexico and Morelos) with high frequencies of greenhouse activity. We interviewed and collected blood samples from 264 females (floriculturists or partners of floricultural workers) who became pregnant during the 10 years prior to the interview. The questionnaire measured socioeconomic characteristics, tobacco and alcohol consumption, diseases and occupational and reproductive history. We also applied a food frequency questionnaire. Information was obtained pertaining to 467 pregnancies. DNA was extracted from white cells, and PON1 genotype was determined by Restriction Fragment Length Polymorphism for Q192R polymorphisms. Results were analyzed with generalized estimating equations models. Results: After adjusting for potential confounders, we detected a statistically significant interaction between maternal exposure to flower growing work during pregnancy and PON1 Q192R polymorphisms on risk of low birth weight. The risk of having a baby with LBW is nearly six times higher if a mother is a floriculture worker during pregnancy and has PON1 192RR genotype (OR 5.93, 95% CI 1.28, 27.5). Conclusion: These results suggest that the interaction between maternal floriculture work during pregnancy and 192RR PON1

  14. Maternal exposure to floricultural work during pregnancy, PON1 Q192R polymorphisms and the risk of low birth weight

    International Nuclear Information System (INIS)

    Moreno-Banda, G.; Blanco-Munoz, J.; Lacasana, M.; Rothenberg, S.J.; Aguilar-Garduno, C.; Gamboa, R.; Perez-Mendez, O.

    2009-01-01

    Background: Although there is evidence from animal studies of impaired reproductive function by exposure to organophosphates (OP), the effects on birth weight have not been sufficiently evaluated in epidemiological studies. Paraoxonase (PON1) detoxifies organophosphates by cleavage of active oxons. Some PON1 gene polymorphisms could reduce the enzyme activity and increase susceptibility to OP toxicity. Objective: To assess the association between maternal exposure to floriculture during pregnancy and the risk of low birth weight (< 2500 g) in their offspring, as well as to evaluate the interaction between this exposure and maternal genotype for PON1 Q192R polymorphisms. Materials and methods: A cross sectional study was carried out in two Mexican states (States of Mexico and Morelos) with high frequencies of greenhouse activity. We interviewed and collected blood samples from 264 females (floriculturists or partners of floricultural workers) who became pregnant during the 10 years prior to the interview. The questionnaire measured socioeconomic characteristics, tobacco and alcohol consumption, diseases and occupational and reproductive history. We also applied a food frequency questionnaire. Information was obtained pertaining to 467 pregnancies. DNA was extracted from white cells, and PON1 genotype was determined by Restriction Fragment Length Polymorphism for Q192R polymorphisms. Results were analyzed with generalized estimating equations models. Results: After adjusting for potential confounders, we detected a statistically significant interaction between maternal exposure to flower growing work during pregnancy and PON1 Q192R polymorphisms on risk of low birth weight. The risk of having a baby with LBW is nearly six times higher if a mother is a floriculture worker during pregnancy and has PON1 192RR genotype (OR 5.93, 95% CI 1.28, 27.5). Conclusion: These results suggest that the interaction between maternal floriculture work during pregnancy and 192RR PON1

  15. The neuroprotective effect of lovastatin on MPP(+)-induced neurotoxicity is not mediated by PON2.

    Science.gov (United States)

    Aguirre-Vidal, Yoshajandith; Montes, Sergio; Tristan-López, Luis; Anaya-Ramos, Laura; Teiber, John; Ríos, Camilo; Baron-Flores, Verónica; Monroy-Noyola, Antonio

    2015-05-01

    Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of the pigmented dopaminergic neurons in the substantia nigra pars compacta with subsequent striatal dopamine (DA) deficiency and increased lipid peroxidation. The etiology of the disease is still unclear and it is thought that PD may be caused by a combination of genetic and environmental factors. In the search of new pharmacological options, statins have been recognized for their potential application to treat PD, due to their antioxidant effect. The aim of this work is to contribute in the characterization of the neuroprotective effect of lovastatin in a model of PD induced by 1-methyl-4-phenylpyridinium (MPP(+)). Male Wistar rats (200-250 g) were randomly allocated into 4 groups and administered for 7 days with different pharmacological treatments. Lovastatin administration (5 mg/kg) diminished 40% of the apomorphine-induced circling behavior, prevented the striatal DA depletion and lipid peroxides formation by MPP(+) intrastriatal injection, as compared to the group of animals treated only with MPP(+). Lovastatin produced no change in paraoxonase-2 (PON2) activity. It is evident that lovastatin conferred neuroprotection against MPP(+)-induced protection but this effect was not associated with the induction of PON2 in the rat striatum. Copyright © 2015. Published by Elsevier B.V.

  16. Decreased serum paraoxonase 1 (PON1) activity: an additional risk factor for atherosclerotic heart disease in patients with PCOS?

    Science.gov (United States)

    Dursun, Polat; Demirtaş, Ezgi; Bayrak, Ahmet; Yarali, Hakan

    2006-01-01

    Patients with polycystic ovary syndrome (PCOS) may have an increased risk for the development of hypertension and atherosclerotic heart disease (AHD), the pathophysiological mechanisms of which are not clear. Paraoxonase1 (PON1) is a high-density lipoprotein-associated enzyme that prevents oxidative modification of low-density lipoprotein. The aim of this study was to measure the serum levels of PON1 activity in patients with PCOS and to compare with those of regularly cycling controls. Serum lipid parameters, malondialdehyde (MDA) levels and PON1 activity, were measured in PCOS patients (n = 23) and regularly cycling, age-, body mass index- and smoking status-matched controls (n = 23). All patients had normal glucose tolerance test as assessed by a 75 g oral glucose tolerance test. None of the patients had clinically evident hypertension or AHD. Apart from the mean serum PON1 activity, all parameters in the lipid profile including serum MDA levels were comparable between the two groups. There were no significant differences in respect to fasting glucose (4.64 +/- 0.5 versus 4.43 +/- 0.83 mmol/l) and fasting glucose insulin ratio (11.06 +/- 8.26 versus 11.49 +/- 4.90) among the two groups (P > 0.05). However, HOMA insulin resistance index was significantly higher in patients with PCOS compared with the controls (2.06 +/- 0.86 versus 1.51 +/- 0.49; P = 0.01). Also, mean serum PON1 activity was significantly lower in the PCOS group compared with the controls (151.2 +/- 90.8 versus 217.7 +/- 101.6, respectively; P = 0.027). Reduced serum PON1 activity might contribute to the increased susceptibility for the development of AHD in women with PCOS.

  17. Investigation of PON1 activity and MDA levels in patients with epilepsy not receiving antiepileptic treatment

    Directory of Open Access Journals (Sweden)

    Dönmezdil N

    2016-04-01

    Full Text Available Nilüfer Dönmezdil, Mehmet Uğur Çevik, Hasan Hüseyin Özdemir, Muhterem Taşin Department of Neurology, Dicle University, Diyarbakır, Turkey Purpose: There are many studies dedicated to researching the etiopathogenesis of epilepsy. In such research, oxidative and antioxidant indicators of etiopathogenesis have also been examined under the scope. Drawing on a group of patients with epilepsy who were receiving no treatment, we have tried to evaluate whether or not an increase in oxidative indicators is linked directly with the disorder, independent of epileptic medicaments.Methods: Thirty people in good health and 30 newly diagnosed with epilepsy and who received ambulatory treatment in the polyclinic of the Neurology Department took part in the study. The tests relating to serum malondialdehyde (MDA levels and paraoxonase 1 (PON1 activity were carried out in the biochemistry laboratory.Results: Even though the levels of MDA in the patient group (14.34±3.59 nmol/mL were found to be high compared to those of the control group, which consisted of people in good health (13.53±3.56 nmol/mL, there was no statistically significant difference. PON1 activity in the serum taken from people in the patient group (0.65±0.17 was lower in comparison to that observed in the serum of the control group (0.71±0.17 U/L. Nonetheless, it was not so low as to have significance from a statistical point of view.Conclusion: We conclude that such a high level of oxidative parameters should have been related to the disease and that statistically significant findings that emerged in some other studies could have been related to an antiepileptic treatment. Keywords: epilepsy, paraoxonase 1, malondialdehyde, oxidative stress, epilepsy, biochemical marker

  18. Association of genetic polymorphisms of PON1 and CETP with the presence of metabolic syndrome; the effects of genotypes on their serum activity and concentrations

    Directory of Open Access Journals (Sweden)

    Behdokht Fathi Dizaji

    2018-01-01

    Conclusions: There were no associations between the PON1 polymorphisms, or haplotypes with MetS. There was an association between CETPrs5882 and metabolic syndrome. AA genotype of CETPrs5882 appeared to be protective against MetS in our studied population. There were no association between the PON1 and CETP polymorphisms with PON1enzymatic activities and CETP protein levels at base line and after curcumin supplementation.

  19. Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism

    Energy Technology Data Exchange (ETDEWEB)

    Cole, Toby B.; Walter, Betsy J.; Shih, Diana M.; Tward, Aaron D.; Lusis, Aldons J.; Timchalk, Chuck; Richter, Rebecca J.; Costa, Lucio G.; Furlong, Clement E.

    2005-08-01

    The Q192R polymorphism of paraoxonase (PON1) has been shown to affect hydrolysis of organophosphorus compounds. The Q192 and R192 alloforms exhibit equivalent catalytic efficiencies of hydrolysis for diazoxon, the oxon form of the pesticide (DZ). However, the R192 alloform has a higher catalytic efficiency of hydrolysis than does the Q192 alloform for chlorpyrifos oxon (CPO), the oxon form of the pesticide chlorpyrifos (CPS). The current study examined the relevance of these observations for in-vivo exposures to chlorpyrifos and chlorpyrifos oxon. Methods Using a transgenic mouse model we examined the relevance of the Q192R polymorphism for exposure to CPS and CPO in vivo. Transgenic mice were generated that expressed either human PON1Q192 or PON1R192 at equivalent levels, in the absence of endogenous mouse PON1. Dose-response and time course experiments were performed on adult mice exposed dermally to CPS or CPO. Morbidity and acetylcholinesterase (AChE) activity in the brain and diaphragm were determined in the first 24 h following exposure. Results Mice expressing PON1Q192 were significantly more sensitive to CPO, and to a lesser extent CPS, than were mice expressing PON1R192. The time course of inhibition following exposure to 1.2 mg/kg CPO revealed maximum inhibition of brain AChE at 6?12 h, with PON1R192, PON1Q192, and PON1? /? mice exhibiting 40, 70 and 85% inhibition, respectively, relative to control mice. The effect of PON1 removal on the dose?response curve for CPS exposure was remarkably consistent with a PBPK/PD model of CPS exposure. Conclusion These results indicate that individuals expressing only the PON1Q192 allele would be more sensitive to the adverse effects of CPO or CPS exposure, especially if they are expressing a low level of plasma PON1Q192.

  20. Repeated Gestational Exposure of Mice to Chlorpyrifos Oxon Is Associated with Paraoxonase 1 (PON1) Modulated Effects in Maternal and Fetal Tissues

    Science.gov (United States)

    Co, Aila L.; Hay, Ariel M.; MacDonald, James W.; Bammler, Theo K.; Farin, Federico M.; Costa, Lucio G.; Furlong, Clement E.

    2014-01-01

    Chlorpyrifos oxon (CPO), the toxic metabolite of the organophosphorus (OP) insecticide chlorpyrifos, causes developmental neurotoxicity in humans and rodents. CPO is hydrolyzed by paraoxonase-1 (PON1), with protection determined by PON1 levels and the human Q192R polymorphism. To examine how the Q192R polymorphism influences fetal toxicity associated with gestational CPO exposure, we measured enzyme inhibition and fetal-brain gene expression in wild-type (PON1+/+), PON1-knockout (PON1−/−), and tgHuPON1R192 and tgHuPON1Q192 transgenic mice. Pregnant mice exposed dermally to 0, 0.50, 0.75, or 0.85 mg/kg/d CPO from gestational day (GD) 6 through 17 were sacrificed on GD18. Biomarkers of CPO exposure inhibited in maternal tissues included brain acetylcholinesterase (AChE), red blood cell acylpeptide hydrolase (APH), and plasma butyrylcholinesterase (BChE) and carboxylesterase (CES). Fetal plasma BChE was inhibited in PON1−/− and tgHuPON1Q192, but not PON1+/+ or tgHuPON1R192 mice. Fetal brain AChE and plasma CES were inhibited in PON1−/− mice, but not in other genotypes. Weighted gene co-expression network analysis identified five gene modules based on clustering of the correlations among their fetal-brain expression values, allowing for correlation of module membership with the phenotypic data on enzyme inhibition. One module that correlated highly with maternal brain AChE activity had a large representation of homeobox genes. Gene set enrichment analysis revealed multiple gene sets affected by gestational CPO exposure in tgHuPON1Q192 but not tgHuPON1R192 mice, including gene sets involved in protein export, lipid metabolism, and neurotransmission. These data indicate that maternal PON1 status modulates the effects of repeated gestational CPO exposure on fetal-brain gene expression and on inhibition of both maternal and fetal biomarker enzymes. PMID:25070982

  1. Vasospastic angina and microvascular angina are differentially influenced by PON1 A632G polymorphism in the Japanese.

    Science.gov (United States)

    Mashiba, Junko; Koike, George; Kamiunten, Hitoshi; Ikeda, Manami; Sunagawa, Kenji

    2005-12-01

    Ethnicity and smoking are well-known risk factors for the pathogenesis of coronary vasospasm. Oxidative stress induced by smoking plays a crucial role in coronary vasospasm, but is not enough to account for the pathogenesis of coronary vasospasm, indicating that genetic factors are strongly involved. The study group comprised 162 vasospastic angina patients (VSAs), 61 microvascular angina patients (MVAs) and 61 non-responders (NRs) diagnosed by acetylcholine provocation test. Four polymorphisms of the oxidative stress related genes, cytochrome b-245, alpha polypeptide gene (CYBA) C242T and A640G, paraoxonase 1 gene (PON1) A632G, phospholipase A2 group VII gene (PLA2G7) G994T were genotyped. Allele frequency of PON1 632-G was significantly higher in both the VSA with dominant fashion and the MVA with recessive fashion compared with NR. This association was strongly influenced by gender in the MVA only. There were no significant associations between the other polymorphisms and coronary vasospasm. In addition, the allele frequency of PON1 632-G in the Japanese was higher than in Caucasians. There was a significant association between PON1 A632G polymorphism and MVA as well as VSA, but the impact of this on VSA and MVA is different in the Japanese.

  2. Polymorphisms in xenobiotic metabolizing genes (EPHX1, NQO1 and PON1) in lymphoma susceptibility: a case control study

    International Nuclear Information System (INIS)

    Conesa-Zamora, Pablo; Vicente, Vicente; Pérez-Guillermo, Miguel; Ruiz-Cosano, Javier; Torres-Moreno, Daniel; Español, Ignacio; Gutiérrez-Meca, María D; Trujillo-Santos, Javier; Pérez-Ceballos, Elena; González-Conejero, Rocío; Corral, Javier

    2013-01-01

    The interplay between genetic susceptibility and carcinogenic exposure is important in the development of haematopoietic malignancies. EPHX1, NQO1 and PON1 are three genes encoding proteins directly involved in the detoxification of potential carcinogens. We have studied the prevalence of three functional polymorphisms affecting these genes rs1051740 EPHX1, rs1800566 NQO1 and rs662 PON1 in 215 patients with lymphoma and 214 healthy controls. Genotype frequencies for EPHX and NQO1 polymorphisms did not show any correlation with disease. In contrast, the GG genotype in the PON1 polymorphism was found to be strongly associated with the disease (15.3% vs. 4.7%; OR = 3.7 CI (95%): 1.8-7.7; p < 0.001). According to the pathological diagnosis this association was related to follicular (p = 0.004) and diffuse large B-cell (p = 0.016) lymphomas. Despite the fact that further confirmation is needed, this study shows that the PON1 GG genotype in rs662 polymorphism could be a risk factor for B-cell lymphomas

  3. Aerobic Training Modulates the Effects of Exercise-Induced Oxidative Stress on PON1 Activity: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    Aneta Otocka-Kmiecik

    2014-01-01

    Full Text Available The aim of the study was to compare the effect of maximal exercise (ME on paraoxonase (PON and arylesterase (ARE activity depending on lifestyle in respect to physical activity. The study was performed on 46 young men divided into two groups: sedentary (S and physically active (PA. All participants performed ME on a treadmill. PON1 activities, FRAP, uric acid, bilirubin, TBARS, and lipid profile were determined in their blood before, at the bout of, and after ME. No significant differences in PON1 activities were found between S and PA subjects at baseline. Nearly all biochemicals increased at ME in both groups. Both PON and ARE activity increased at the bout of ME in PA subjects and only ARE activity in S subjects. ARE/HDL-C ratio increased at the bout of ME in PA and S subjects. The difference in PON1 activity response to ME between study groups may be a result of adaptation of PA subjects to regular physical activity. We suggest that PON1 activity may be a marker of antioxidant protection at ME and an indicator of adaptation to exercise.

  4. Aerobic training modulates the effects of exercise-induced oxidative stress on PON1 activity: a preliminary study.

    Science.gov (United States)

    Otocka-Kmiecik, Aneta; Lewandowski, Marek; Szkudlarek, Urszula; Nowak, Dariusz; Orlowska-Majdak, Monika

    2014-01-01

    The aim of the study was to compare the effect of maximal exercise (ME) on paraoxonase (PON) and arylesterase (ARE) activity depending on lifestyle in respect to physical activity. The study was performed on 46 young men divided into two groups: sedentary (S) and physically active (PA). All participants performed ME on a treadmill. PON1 activities, FRAP, uric acid, bilirubin, TBARS, and lipid profile were determined in their blood before, at the bout of, and after ME. No significant differences in PON1 activities were found between S and PA subjects at baseline. Nearly all biochemicals increased at ME in both groups. Both PON and ARE activity increased at the bout of ME in PA subjects and only ARE activity in S subjects. ARE/HDL-C ratio increased at the bout of ME in PA and S subjects. The difference in PON1 activity response to ME between study groups may be a result of adaptation of PA subjects to regular physical activity. We suggest that PON1 activity may be a marker of antioxidant protection at ME and an indicator of adaptation to exercise.

  5. The Q192R polymorphism of the paraoxonase-1 (PON1) gene is associated with susceptibility to gestational diabetes mellitus in the Greek population.

    Science.gov (United States)

    Pappa, Kalliopi I; Gazouli, Maria; Anastasiou, Eleni; Loutradis, Dimitrios; Anagnou, Nicholas P

    2017-08-01

    A key factor protecting from oxidative stress in gestational diabetes mellitus (GDM) and in type 2 diabetes (T2D) is paraoxonase-1 (PON1). Inconclusive and limited data exist regarding the effect of a coding polymorphism (Q192R) of the PON1 gene in conferring susceptibility to both states. In the present study, we investigated the association between the PON1 gene and the risk for GDM in the Greek population and assessed for the first time its transcriptional efficiency. We studied 185 women with GDM and 104 non-diabetic controls for the PON1 polymorphism. For PON1 mRNA expression, peripheral leucocytes were harvested from 20 GDM and 20 control women, harboring different genotypes for the polymorphism, using real-time quantitative PCR. The RR genotype and the R allele of the PON1 Q192R polymorphism were significantly associated with an increased risk for GDM (p = 0.012 and p < 0.0001, respectively). Furthermore, there was no statistical correlation between the individual metabolic parameters tested and the three genotypes. Finally, the expression levels of PON1 mRNA in GDM patients did not exhibit any statistical difference compared with normal controls (p = 0.138). These data independently document that the Q192R polymorphism is closely associated with GDM susceptibility, while the PON1 gene expression is not impaired in GDM.

  6. Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis.

    Science.gov (United States)

    Rea, Irene M; McKeown, Pascal P; McMaster, Dorothy; Young, Ian S; Patterson, Chris; Savage, Maurice J; Belton, Christine; Marchegiani, Francesca; Olivieri, Fabiola; Bonafe, Massimiliano; Franceschi, Claudio

    2004-04-01

    PON1, an arylesterase, associated with high density lipoprotein (HDL), protects low density lipoprotein (LDL) against oxidative modification. Common polymorphisms PON1 55 (L/M) and 192 (Q/R) in the PON1 gene associate with atherosclerosis and heart disease. Because long-lived people seem protected from premature vascular death, we conducted a pooled statistical analysis to assess any association between these polymorphisms and longevity in a large combined group of Italian centenarians and octo/nonagenarians from Northern Ireland (NI). Separated DNA was available from 1479 subjects from Italy and Northern Ireland (NI). In Italy 308 centenarians (males 67, females 241, mean age 100.8, SD2.1 years) and 579 young controls (males 347, females 232, mean age 40.7, SD 12.7 years) were included in the study. In NI, 296 octo/nonagenarians (males 92, females 204, mean age 89.8, SD 5.7 years) and 296 young sex-matched subjects (mean age 13.0, SD 1.4 years) had available DNA. PON1 55 (L/M) and 192 (Q/R) polymorphisms were studied using a PCR-RFLP approach. There was a significant difference in PON1 192 genotypes in Italian centenarians compared to younger controls (X(2)= 6.8, df = 2 p= 0.03) and a similar but non significant trend between octo/nonagenarian and young subjects in NI (X(2) = 4.0, df=2, p=0.14). Using logistic regression analysis on the combined Italian and Irish datasets, there was a small survival advantage for centenarian and octo/nonagenarian subjects who were heterozygous for PON1 192 R allele, (OR 1.3, CI 1-1.6; p=0.04 with a stepwise increase for RR homozygous subjects (OR 1.7, CI 1.1-2.6; p = 0.02) compared to QQ subjects. Comparing R and Q alleles there was a survival advantage for octo/nonagenarian/centenarian subjects who carried the R allele (OR 1.3, CI 1.1-1.5; p = 0.007) but there was no sex-specific effect p =0.77) LL, LM and MM genotypes of PON 55 polymorphisms showed similar frequencies in Italy (39.9, 47.0, 13.1%) and Ireland (39.5, 48.6, 11

  7. Associations of maternal organophosphate pesticide exposure and PON1 activity with birth outcomes in SAWASDEE birth cohort, Thailand

    Science.gov (United States)

    Naksen, Warangkana; Prapamontol, Tippawan; Mangklabruks, Ampica; Chantara, Somporn; Thavornyutikarn, Prasak; Srinual, Niphan; Panuwet, Parinya; Ryan, P. Barry; Riederer, Anne M.; Barr, Dana Boyd

    2015-01-01

    Prenatal organophosphate (OP) pesticide exposure has been reported to be associated with adverse birth outcomes and neurodevelopment. However, the mechanisms of toxicity of OP pesticides on human fetal development have not yet been elucidated. Our pilot study birth cohort, the Study of Asian Women and Offspring’s Development and Environmental Exposures (SAWASDEE cohort) aimed to evaluate environmental chemical exposures and their relation to birth outcomes and infant neurodevelopment in 52 pregnant farmworkers in Fang district, Chiang Mai province, Thailand. A large array of data was collected multiple times during pregnancy including approximately monthly urine samples for evaluation of pesticide exposure, three blood samples for pesticide-related enzyme measurements and questionnaire data. This study investigated the changes in maternal acetylcholinesterase (AChE) and paraoxonase 1 (PON1) activities and their relation to urinary diakylphosphates (DAPs), class-related metabolites of OP pesticides, during pregnancy. Maternal AChE, butyrylcholinesterase (BChE) and PON1 activities were measured three times during pregnancy and urinary DAP concentrations were measured, on average, 8 times from enrollment during pregnancy until delivery. Among the individuals in the group with low maternal PON1 activity (n = 23), newborn head circumference was negatively correlated with log10 maternal ΣDEAP and ΣDAP at enrollment (gestational age=12±3 weeks; β = −1.0 cm, p = 0.03 and β = −1.8 cm, p <0.01, respectively) and at 32 weeks pregnancy (β = −1.1 cm, p = 0.04 and β = −2.6 cm, p = 0.01, respectively). Furthermore, among these mothers, newborn birthweight was also negatively associated with log10 maternal ΣDEAP and ΣDAP at enrollment (β = −219.7 g, p = 0.05 and β = −371.3 g, p = 0.02, respectively). Associations between maternal DAP levels and newborn outcomes were not observed in the group of participants with high maternal PON1 activity. Our results

  8. PON1Q192R genetic polymorphism modifies organophosphorous pesticide effects on semen quality and DNA integrity in agricultural workers from southern Mexico

    International Nuclear Information System (INIS)

    Perez-Herrera, N.; Polanco-Minaya, H.; Salazar-Arredondo, E.; Solis-Heredia, M.J.; Hernandez-Ochoa, I.; Rojas-Garcia, E.; Alvarado-Mejia, J.; Borja-Aburto, V.H.; Quintanilla-Vega, B.

    2008-01-01

    Pesticide exposure, including organophosphorous (OP) insecticides, has been associated with poor semen quality, and paraoxonase (PON1), an enzyme involved in OP deactivation, may have a role on their susceptibility, due to PON1 polymorphisms. Our objective was to evaluate the role of PON1Q192R polymorphism on the susceptibility to OP toxicity on semen quality and DNA integrity in agricultural workers. A cross-sectional study was conducted in farmers with Mayan ascendancy from southeastern Mexico chronically exposed to pesticides; mostly OP. Fifty four agricultural workers (18-55 years old) were included, who provided semen and blood samples. Semen quality was evaluated according to WHO, sperm DNA damage by in situ-nick translation (NT-positive cells), PON1Q192R polymorphism by real-time PCR and serum PON1 activity by using phenylacetate and paraoxon. Two OP exposure indexes were created: at the month of sampling and during 3 months before sampling, representing the exposure to spermatids-spermatozoa and to cells at one spermatogenic cycle, respectively. PON1 192R and 192Q allele frequencies were 0.54 and 0.46, respectively. Significant associations were found between OP exposure at the month of sampling and NT-positive cells and sperm viability in homozygote 192RR subjects, and dose-effect relationships were observed between OP exposure during 3 months before sampling and sperm quality parameters and NT-positive cells in homozygote 192RR farmers. This suggests that cells at all stages of spermatogenesis are target of OP, and that there exists an interaction between OP exposure and PON1Q192R polymorphism on these effects; farmers featuring the 192RR genotype were more susceptible to develop reproductive toxic effects by OP exposure

  9. CYP2C19 and PON1 polymorphisms regulating clopidogrel bioactivation in Chinese, Malay and Indian subjects.

    Science.gov (United States)

    Chan, Mark Y; Tan, Karen; Tan, Huay-Cheem; Huan, Pei-Tee; Li, Bei; Phua, Qian-Hui; Lee, Hong-Kai; Lee, Chi-Hang; Low, Adrian; Becker, Richard C; Ong, Wen-Chong; Richards, Mark A; Salim, Agus; Tai, E-Shyong; Koay, Evelyn

    2012-04-01

    AIM, MATERIALS & METHODS: We investigated the functional significance of CYP2C19*2, *3, *17 and PON1 Q192R SNPs in 89 consecutive Asian patients on clopidogrel treatment and the prevalence of functionally significant polymorphisms among 300 Chinese, Malays and Asian Indians. Both CYP2C19 loss-of-function alleles (*2 or *3) were associated with higher platelet reactivity while the CYP2C19 gain-of-function allele (*17) had lower platelet reactivity. For PON1, the median PRI was not significantly different between the QQ, QR and RR groups. The allele frequencies of CYP2C19*2, CYP2C19*3 and CYP2C19*17 were 0.280, 0.065 and 0.010 (rare) for Chinese, 0.310, 0.050 and 0.025 for Malays, and 0.375, 0.010 (rare) and 0.165 for Indians, respectively. Our data suggest that genotyping studies to investigate clopidogrel response should include CYP2C19*2 and *3 but not *17 polymorphisms in Chinese, and CYP2C19*2 and *17 polymorphisms but not *3 in Indians. All three polymorphisms should preferably be genotyped in Malays.

  10. p.Q192R SNP of PON1 seems not to be Associated with Carotid Atherosclerosis Risk Factors in an Asymptomatic and Normolipidemic Brazilian Population Sample

    Directory of Open Access Journals (Sweden)

    Daniel Zanetti Scherrer

    2015-07-01

    Full Text Available Background:Evidences suggest that paraoxonase 1 (PON1 confers important antioxidant and anti-inflammatory properties when associated with high-density lipoprotein (HDL.Objective:To investigate the relationships between p.Q192R SNP of PON1, biochemical parameters and carotid atherosclerosis in an asymptomatic, normolipidemic Brazilian population sample.Methods:We studied 584 volunteers (females n = 326, males n = 258; 19-75 years of age. Total genomic DNA was extracted and SNP was detected in the TaqMan® SNP OpenArray® genotyping platform (Applied Biosystems, Foster City, CA. Plasma lipoproteins and apolipoproteins were determined and PON1 activity was measured using paraoxon as a substrate. High-resolution β-mode ultrasonography was used to measure cIMT and the presence of carotid atherosclerotic plaques in a subgroup of individuals (n = 317.Results:The presence of p.192Q was associated with a significant increase in PON1 activity (RR = 12.30 (11.38; RQ = 46.96 (22.35; QQ = 85.35 (24.83 μmol/min; p Conclusion:In low-risk individuals, the presence of the p.192Q variant of PON1 is associated with a beneficial plasma lipid profile but not with carotid atherosclerosis.

  11. PON1 L55M and Q192R gene polymorphisms and CAD risks in patients with hyperlipidemia : Clinical study of possible associations.

    Science.gov (United States)

    Chen, H; Ding, S; Zhou, M; Wu, X; Liu, X; Liu, J; Wu, Y; Liu, D

    2017-08-23

    A decreased plasma high density lipoprotein (HDL) cholesterol level is a strong risk factor for coronary artery disease (CAD). Antioxidant activity of HDL mainly lies in the activity of paraoxonase (PON). This study aimed to investigate the relationships between PON1 L55M and Q192R polymorphisms, and the risks of CAD in patients with hyperlipidemia. From January 2014 to January 2016, 244 patients were divided into hyperlipidemia, hyperlipidemia + CAD, and control groups. The hyperlipidemia and hyperlipidemia + CAD groups were designated as the case group. Serum PON1 concentrations were measured using the enzyme-linked immunosorbent assay. After isolating genomic DNA, the PON1 L55M and Q192R genes were amplified by polymerase chain reaction and sequenced. In the case group, the genotypes LM and LL were detected significantly more often than in the control group, as were the alleles R (33.33%, 42.12%) and L (22.78%, 29.11%). The frequency of QR and RR genotypes was significantly higher in the hyperlipidemia + CAD group than in the hyperlipidemia group; the allele R in the hyperlipidemia + CAD group (42.77%) was more frequent than in the hyperlipidemia group (23.78%). The Q192R polymorphism was associated with low serum PON1 concentrations, and the lowest concentration was observed in the 192QR + 192RR genotype (P = 0.03). Logistic regression analysis showed a significant correlation between the 192R allele and smoking (P = 0.03), body mass index (P = 0.02), systolic blood pressure (P = 0.004), total cholesterol (P = 0.03), triglycerides (P = 0.01), HDL (P = 0.004), and low density lipoprotein (P = 0.02). The PON1 alleles 192R and 55L are associated with CAD, and the Q192R polymorphism may be a risk factor for CAD.

  12. p.Q192R SNP of PON1 seems not to be Associated with Carotid Atherosclerosis Risk Factors in an Asymptomatic and Normolipidemic Brazilian Population Sample

    Science.gov (United States)

    Scherrer, Daniel Zanetti; Zago, Vanessa Helena de Souza; Vieira, Isabela Calanca; Parra, Eliane Soler; Panzoldo, Natália Baratella; Alexandre, Fernanda; Secolin, Rodrigo; Baracat, Jamal; Quintão, Eder Carlos Rocha; de Faria, Eliana Cotta

    2015-01-01

    Background Evidences suggest that paraoxonase 1 (PON1) confers important antioxidant and anti-inflammatory properties when associated with high-density lipoprotein (HDL). Objective To investigate the relationships between p.Q192R SNP of PON1, biochemical parameters and carotid atherosclerosis in an asymptomatic, normolipidemic Brazilian population sample. Methods We studied 584 volunteers (females n = 326, males n = 258; 19-75 years of age). Total genomic DNA was extracted and SNP was detected in the TaqMan® SNP OpenArray® genotyping platform (Applied Biosystems, Foster City, CA). Plasma lipoproteins and apolipoproteins were determined and PON1 activity was measured using paraoxon as a substrate. High-resolution β-mode ultrasonography was used to measure cIMT and the presence of carotid atherosclerotic plaques in a subgroup of individuals (n = 317). Results The presence of p.192Q was associated with a significant increase in PON1 activity (RR = 12.30 (11.38); RQ = 46.96 (22.35); QQ = 85.35 (24.83) μmol/min; p < 0.0001), HDL-C (RR= 45 (37); RQ = 62 (39); QQ = 69 (29) mg/dL; p < 0.001) and apo A-I (RR = 140.76 ± 36.39; RQ = 147.62 ± 36.92; QQ = 147.49 ± 36.65 mg/dL; p = 0.019). Stepwise regression analysis revealed that heterozygous and p.192Q carriers influenced by 58% PON1 activity towards paraoxon. The univariate linear regression analysis demonstrated that p.Q192R SNP was not associated with mean cIMT; as a result, in the multiple regression analysis, no variables were selected with 5% significance. In logistic regression analysis, the studied parameters were not associated with the presence of carotid plaques. Conclusion In low-risk individuals, the presence of the p.192Q variant of PON1 is associated with a beneficial plasma lipid profile but not with carotid atherosclerosis. PMID:26039660

  13. Insights into the Lactonase Mechanism of Serum Paraoxonase 1 (PON1): Experimental and Quantum Mechanics/Molecular Mechanics (QM/MM) Studies.

    Science.gov (United States)

    Le, Quang Anh Tuan; Kim, Seonghoon; Chang, Rakwoo; Kim, Yong Hwan

    2015-07-30

    Serum paraoxonase 1 (PON1) is a versatile enzyme for the hydrolysis of various substrates (e.g., lactones, phosphotriesters) and for the formation of a promising chemical platform γ-valerolactone. Elucidation of the PON1-catalyzed lactonase reaction mechanism is very important for understanding the enzyme function and for engineering this enzyme for specific applications. Kinetic study and hybrid quantum mechanics/molecular mechanics (QM/MM) method were used to investigate the PON1-catalyzed lactonase reaction of γ-butyrolactone (GBL) and (R)-γ-valerolactone (GVL). The activation energies obtained from the QM/MM calculations were in good agreement with the experiments. Interestingly, the QM/MM energy barriers at MP2/3-21G(d,p) level for the lactonase of GVL and GBL were respectively 14.3-16.2 and 11.5-13.1 kcal/mol, consistent with the experimental values (15.57 and 14.73 kcal/mol derived from respective kcat values of 36.62 and 147.21 s(-1)). The QM/MM energy barriers at MP2/6-31G(d) and MP2/6-31G(d,p) levels were also in relatively good agreements with the experiments. Importantly, the difference in the QM/MM energy barriers at MP2 level with all investigated basis sets for the lactonase of GVL and GBL were in excellent agreement with the experiments (0.9-3.1 and 0.8 kcal/mol, respectively). A detailed mechanism for the PON1-catalyzed lactonase reaction was also proposed in this study.

  14. Human serum paraoxonase-1 (hPON1): in vitro inhibition effects of moxifloxacin hydrochloride, levofloxacin hemihidrate, cefepime hydrochloride, cefotaxime sodium and ceftizoxime sodium.

    Science.gov (United States)

    Türkeş, Cüneyt; Söyüt, Hakan; Beydemir, Şükrü

    2015-01-01

    In this study, we investigated the effects of antibacterial drugs (moxifloxacin hydrochloride, levofloxacin hemihidrate, cefepime hydrochloride, cefotaxime sodium and ceftizoxime sodium) on human serum paraoxonase-1 (hPON1) enzyme activity from human serum in vitro conditions. For this purpose, hPON1 enzyme was purified from human serum using simple chromatographic methods. The antibacterial drugs exhibited inhibitory effects on hPON1 at low concentrations. Ki constants were calculated to be 2.641 ± 0.040 mM, 5.525 ± 0.817 mM, 35.092 ± 1.093 mM, 252.762 ± 5.749 mM and 499.244 ± 10.149 mM, respectively. The inhibition mechanism of moxifloxacin hydrochloride was competitive, whereas levofloxacin hemihidrate, cefepime hydrochloride, cefotaxime sodium and ceftizoxime sodium were noncompetitive inhibitors.

  15. RISET STRATEGI IMPLEMENTASI C-RAN DI TELKOMSEL MELALUI KOLABORASI JARINGAN NG-PON2 DI TELKOM AKSES MENGGUNAKAN PENDEKATAN METODE STRATEGIC SITUATION ANALYSIS

    Directory of Open Access Journals (Sweden)

    Tri Susanto

    2007-07-01

    Full Text Available Cloud Radio Access Network (C-RAN adalah teknologi akses radio yang diyakini mampu menekan biaya CAPEX dan OPEX dari mobile operator dan memberikan performansi yang lebih baik dibandingkan Radio Access Network (RAN tradisional. Salah satu faktor kunci sukses implementasi C-RAN adalah penyediaan jaringan fonthaul yang efektif. Tujuan penelitian ini adalah membuat strategi implementasi C-RAN di Telkomsel melalui kolaborasi jaringan NG-PON2 di Telkom Akses. Pada tulisan ini menggunakan metode analisis kualitatif dengan melakukan strategy situation analysis (SSA yaitu melakukan analisa data eksternal maupun internal dan selanjutnya diformulasikan sebagai dasar pembuatan strategi implementasi. Dari penelitian ini dihasilkan usulan strategi implementasi C-RAN di Telkomsel melalui kolaborasi jaringan NG-PON2 di Telkom Akses.

  16. Paraoxonase 1 Q192R (PON1-192) polymorphism is associated with reduced lipid peroxidation in healthy young men on a low-carotenoid diet supplemented with tomato juice.

    Science.gov (United States)

    Bub, Achim; Barth, Stephan W; Watzl, Bernhard; Briviba, Karlis; Rechkemmer, Gerhard

    2005-03-01

    The HDL-bound enzyme paraoxonase (PON) protects LDL from oxidation and may therefore attenuate the development of atherosclerosis. We examined the effect of tomato and carrot juice consumption on PON1 activity and lipid peroxidation in healthy young volunteers with different PON1-192 genotypes (Q/R substitution at position 192). In this randomized cross-over study twenty-two healthy, non-smoking men on a low-carotenoid diet received 330 ml/d tomato juice (37.0 mg lycopene, 1.6 mg beta-carotene) or carrot juice (27.1 mg beta-carotene, 13.1 mg alpha-carotene) for 2 weeks. Intervention periods were preceded by 2-week low-carotenoid intake. We determined the PON1-192 genotype by restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) and measured ex vivo LDL oxidation (lag time), plasma malondialdehyde and PON1 activity at the beginning and end of each intervention period. At baseline, lag time was higher (Pjuice consumption had significant effects on PON1 activity. However, tomato juice consumption reduced (Pjuice had no significant effect on malondialdehyde irrespective of the PON1-192 genotype. Male volunteers with the QR/RR genotype showed an increased lipid peroxidation at baseline. Although tomato and carrot juice fail to affect PON1 activity, tomato juice intake reduced lipid peroxidation in healthy volunteers carrying the R-allele of the PON1-192 genotype and could thus contribute to CVD risk reduction in these individuals.

  17. Prenatal pesticide exposure and PON1 genotype associated with adolescent body fat distribution evaluated by dual X-ray absorptiometry (DXA)

    DEFF Research Database (Denmark)

    Tinggaard, Jeanette; Wohlfahrt-Veje, C.; Husby, S

    2016-01-01

    ) at age 10-15. Prenatal pesticide exposure was associated with increased total, android, and gynoid fat% (DXA) at age 10-15 years after adjustment for sex, socioeconomic status, and puberty (all β = 0.5 standard deviation score (SDS) p ... (total fat: β = 0.7 SDS, android-gynoid ratio: β = 0.1, both p ... circumference were found. Prenatal pesticide exposure was associated with higher adolescent body fat content, including android fat deposition, independent of puberty. Girls appeared more susceptible than boys. Furthermore, the association depended on maternal and child PON1 Q192R genotype....

  18. Coronary artery disease and the frequencies of MTHFR and PON1 gene polymorphism studies in a varied population of Hyderabad, Telangana region in south India

    Directory of Open Access Journals (Sweden)

    Kavitha Matam

    2015-04-01

    Full Text Available Coronary artery disease (CAD also known as coronary heart disease is one of the leading causes of death and disability worldwide. Genetic and environmental factors play an important role in the pathogenesis and progression of CAD. The aim of this study was to evaluate the combined contribution of 3 gene polymorphisms to the risk of CAD and gene–gene interaction in the south Indian population. In this case-control study, 200 cases of CAD and 200 healthy controls were recruited. We studied 3 well known genetic polymorphisms of MTHFR (C677T; rs1801133, PON1 (Q192R; rs662 and ACE (I/D: rs4646994 in relation to CAD in South Indian population. Polymerase chain reaction (PCR was carried out and followed by the restriction fragment length polymorphism and agarose gel electrophoresis. Genotypes of MTHFR C677T, CT and CT+TT, and PON1 Q192R QR were associated with the risk of CAD (C677T CT+TT vs CC: odds ratio [OR] = 3.3, 95% confidence intervals [CI] = 1.8–6.2; p = 0.00001, (CT vs CC: OR = 3.2, 95%CI = 1.8–5.6; p = 0.00003, and (Q192R QQ vs QR: OR = 2.1, 95%CI = 1.1–3.9; p = 0.03. The allele frequencies for T vs C: OR = 3.1, 95%CI = 1.8–5.3; p = 0.00001 and R vs Q: OR = 1.3, 95% CI = 1.0–1.7 p = 0.03. Multifactor dimensionality reduction (MDR analysis was carried out with the combination of three genes and the results indicate that MDR analysis showed that, PON1 gene polymorphism formed a significant model in predicting the CAD risk in south Indian population.

  19. Interaction between prenatal pesticide exposure and a common polymorphism in the PON1 gene on DNA methylation in genes associated with cardio-metabolic disease risk-an exploratory study

    DEFF Research Database (Denmark)

    Declerck, Ken; Remy, Sylvie; Wohlfahrt-Veje, Christine

    2017-01-01

    BACKGROUND: Prenatal environmental conditions may influence disease risk in later life. We previously found a gene-environment interaction between the paraoxonase 1 (PON1) Q192R genotype and prenatal pesticide exposure leading to an adverse cardio-metabolic risk profile at school age. However...... was observed in prenatally pesticide exposed children carrying the PON1 192R-allele. Differentially methylated genes were enriched in several neuroendocrine signaling pathways including dopamine-DARPP32 feedback (appetite, reward pathways), corticotrophin releasing hormone signaling, nNOS, neuregulin signaling...

  20. Role of genetic polymorphisms of CYP1A1, CYP3A5, CYP2C9, CYP2D6, and PON1 in the modulation of DNA damage in workers occupationally exposed to organophosphate pesticides

    International Nuclear Information System (INIS)

    Singh, Satyender; Kumar, Vivek; Vashisht, Kapil; Singh, Priyanka; Banerjee, Basu Dev; Rautela, Rajender Singh; Grover, Shyam Sunder; Rawat, Devendra Singh; Pasha, Syed Tazeen; Jain, Sudhir Kumar; Rai, Arvind

    2011-01-01

    Organophosphate pesticides (OPs) are primarily metabolized by several xenobiotic metabolizing enzymes (XMEs). Very few studies have explored genetic polymorphisms of XMEs and their association with DNA damage in pesticide-exposed workers. The present study was designed to determine the role of genetic polymorphisms of CYP1A1, CYP3A5, CYP2C9, CYP2D6, and PON1 in the modulation of DNA damage in workers occupationally exposed to OPs. We examined 284 subjects including 150 workers occupationally exposed to OPs and 134 normal healthy controls. The DNA damage was evaluated using the alkaline comet assay and genotyping was done using PCR–RFLP. The results revealed that the PONase activity toward paraoxonase and AChE activity was found significantly lowered in workers as compared to control subjects (p < 0.001). Workers showed significantly higher DNA damage compared to control subjects (14.37 ± 2.15 vs. 6.24 ± 1.37 tail% DNA, p < 0.001). Further, the workers with CYP2D6*3 PM and PON1 (QQ and MM) genotypes were found to have significantly higher DNA damage when compared to other genotypes (p < 0.05). In addition, significant increase in DNA damage was also observed in workers with concomitant presence of certain CYP2D6 and PON1 (Q192R and L55M) genotypes which need further extensive studies. In conclusion, the results indicate that the PON1 and CYP2D6 genotypes can modulate DNA damage elicited by some OPs possibly through gene-environment interactions. -- Highlights: ► Role of CYP1A1, CYP3A5, CYP2C, CYP2D6 and PON1 genotypes on DNA damage. ► Workers exposed to some OPs demonstrated increased DNA damage. ► CYP2D6 *3 PM and PON1 (Q192R and L55M) genotypes are associated with DNA damage. ► Concomitant presence of certain CYP2D6 and PON1 genotypes can increase DNA damage.

  1. Role of genetic polymorphisms of CYP1A1, CYP3A5, CYP2C9, CYP2D6, and PON1 in the modulation of DNA damage in workers occupationally exposed to organophosphate pesticides

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Satyender [Division of Biochemistry and Biotechnology, National Centre for Disease Control 22, Sham Nath Marg, Delhi-110054 (India); Kumar, Vivek [Environmental Biochemistry and Molecular Biology laboratory, Department of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, Dilshad Garden, Delhi-110095 (India); Vashisht, Kapil; Singh, Priyanka [Division of Biochemistry and Biotechnology, National Centre for Disease Control 22, Sham Nath Marg, Delhi-110054 (India); Banerjee, Basu Dev, E-mail: banerjeebd@hotmail.com [Environmental Biochemistry and Molecular Biology laboratory, Department of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, Dilshad Garden, Delhi-110095 (India); Rautela, Rajender Singh; Grover, Shyam Sunder; Rawat, Devendra Singh; Pasha, Syed Tazeen [Division of Biochemistry and Biotechnology, National Centre for Disease Control 22, Sham Nath Marg, Delhi-110054 (India); Jain, Sudhir Kumar [Centre for Epidemiology and Parasitic Diseases, National Centre for Disease Control 22, Sham Nath Marg, Delhi-110054 (India); Rai, Arvind [Division of Biochemistry and Biotechnology, National Centre for Disease Control 22, Sham Nath Marg, Delhi-110054 (India)

    2011-11-15

    Organophosphate pesticides (OPs) are primarily metabolized by several xenobiotic metabolizing enzymes (XMEs). Very few studies have explored genetic polymorphisms of XMEs and their association with DNA damage in pesticide-exposed workers. The present study was designed to determine the role of genetic polymorphisms of CYP1A1, CYP3A5, CYP2C9, CYP2D6, and PON1 in the modulation of DNA damage in workers occupationally exposed to OPs. We examined 284 subjects including 150 workers occupationally exposed to OPs and 134 normal healthy controls. The DNA damage was evaluated using the alkaline comet assay and genotyping was done using PCR-RFLP. The results revealed that the PONase activity toward paraoxonase and AChE activity was found significantly lowered in workers as compared to control subjects (p < 0.001). Workers showed significantly higher DNA damage compared to control subjects (14.37 {+-} 2.15 vs. 6.24 {+-} 1.37 tail% DNA, p < 0.001). Further, the workers with CYP2D6*3 PM and PON1 (QQ and MM) genotypes were found to have significantly higher DNA damage when compared to other genotypes (p < 0.05). In addition, significant increase in DNA damage was also observed in workers with concomitant presence of certain CYP2D6 and PON1 (Q192R and L55M) genotypes which need further extensive studies. In conclusion, the results indicate that the PON1 and CYP2D6 genotypes can modulate DNA damage elicited by some OPs possibly through gene-environment interactions. -- Highlights: Black-Right-Pointing-Pointer Role of CYP1A1, CYP3A5, CYP2C, CYP2D6 and PON1 genotypes on DNA damage. Black-Right-Pointing-Pointer Workers exposed to some OPs demonstrated increased DNA damage. Black-Right-Pointing-Pointer CYP2D6 *3 PM and PON1 (Q192R and L55M) genotypes are associated with DNA damage. Black-Right-Pointing-Pointer Concomitant presence of certain CYP2D6 and PON1 genotypes can increase DNA damage.

  2. ESTABLISHMENT OF PARAOXONASE AND ARYLESTERASE ACTIVITY OF PARAOXONASE 1 (PON1 IN DEPENDENCE ON 55(L/M AND 192(Q/R DNA POLYMORPHISM IN ADULT PEOPLE WITH DOWN SYNDROME

    Directory of Open Access Journals (Sweden)

    Pavel SÝKORA

    2010-04-01

    Full Text Available Human serum paraoxonase 1 is a calcium-dependent esterase located on high density lipoproteins (HDL. It inhibits LDL peroxidation and hydrolysis of oxide forms of phospholipides and therefore significantly affects the development of ateroscletosis. The aim of this study was to establish the paraoxonase and arylesterase activity of PON1 in adult people with Down syndrome (DS. Adults with DS (10 men and 10 women ages 16 to 37 years participated and were compared to a control group (10 men and 10 women age ranging from 17 to 45 years. The 55(L/M and 192(Q/R DNA polymorphism (PCR-RFLP method and paraoxonase and arylesterase activity was investigated in every patient. The results showed the reduction of PON1 activity in people with DS, in contrast to the decreased development of atherosclerosis in DS. Therefore it can be concluded, that PON1 does not have a direct effect on the lower prevalence of atherosclerosis in people with DS.

  3. The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis

    Directory of Open Access Journals (Sweden)

    Kiessling Matthew

    2004-06-01

    Full Text Available Abstract Background There have been inconsistent results from case-control studies assessing the association of the PON1 Q192R polymorphism with coronary heart disease (CHD. Most studies have included predominantly men and the association in women is unclear. Since lipid levels vary between the sexes the antioxidant effect of PON1 and any genes associated with it may also vary by sex. We have examined the association of the PON1 Q192R polymorphism with CHD in a large cohort of British women and combined the results from our cohort study with those from all other published studies. Results The distribution of genotypes was the same among women with CHD and those without disease. The odds ratio (95% confidence interval of having CHD comparing those with either the QR or RR genotype to those with QQ genotype (dominant model of association was 1.03 (0.89, 1.21 and the per allele odds ratio was 0.98 (0.95, 1.01. In a meta-analysis of this and 38 other published studies (10,738 cases and 17,068 controls the pooled odds ratio for the dominant effect was 1.14 (1.08, 1.20 and for the per allele effect was 1.10 (1.06, 1.13. There was evidence of small study bias in the meta-analyses and the dominant effect among those studies with 500 or more cases was 1.05 (0.96, 1.15. Ethnicity and reporting of whether the genotyping was done blind to the participants clinical status also contributed to heterogeneity between studies, but there was no difference in effect between studies with 50% or more women compared to those with fewer women and no difference between studies of healthy populations compared to those at high risk (with diabetes, renal disease of familial hypercholesterolaemia. Conclusion There is no robust evidence that the PON1 Q192R polymorphism is associated with CHD risk in Caucasian women or men.

  4. Análisis de prestaciones de láseres en redes de acceso ópticas pasivas de siguiente generación NG-PON2 (Next Generation Passive Optical Networks)

    OpenAIRE

    Martín González, Daniel

    2017-01-01

    Este trabajo se centra en el estudio a nivel físico de las redes ópticas de acceso de siguiente generación (NG-PON2, Next Generation Passive Optical Networks), con las que se llegan a conseguir velocidades de transmisión de datos no inferiores a 40Gbits/s. Esto es gracias a la introducción de 4 longitudes de onda en cada sentido de transmisión. Además, estas redes tienen la ventaja añadida de conseguir transmisiones entre el OLT (Optical Line Termination) y las ONUs (Optical Network Units) de...

  5. CYP/PON genetic variations as determinant of organophosphate ...

    Indian Academy of Sciences (India)

    as serum cholinesterase, acetylcholinesterase (Mileson et al. 1998) and ..... human serum. Figure 3. (a) PON1 protein and SNPs with their effect. (b) SNPs of PON1 and PON2 genes. The rs662, rs7493, rs12026 SNPs are present on chromosome 7:94937446, ..... typing of various sequence variants and by using sensitive.

  6. The Search for Dietary Supplements to Elevate or Activate Circulating Paraoxonases

    Directory of Open Access Journals (Sweden)

    José M. Lou-Bonafonte

    2017-02-01

    Full Text Available Low levels of paraoxonase 1 (PON1 have been associated with the development of several pathological conditions, whereas high levels have been shown to be anti-atherosclerotic in mouse models. These findings suggest that PON1 could be a good surrogate biomarker. The other members of the family, namely PON2 and PON3, the role of which has been much less studied, deserve more attention. This paper provides a systematic review of current evidence concerning dietary supplements in that regard. Preliminary studies indicate that the response to dietary supplements may have a nutrigenetic aspect that will need to be considered in large population studies or in clinical trials. A wide range of plant preparations have been found to have a positive action, with pomegranate and some of its components being the best characterized and Aronia melanocarpa one of the most active. Flavonoids are found in the composition of all active extracts, with catechins and genistein being the most promising agents for increasing PON1 activity. However, some caveats regarding the dose, length of treatment, bioavailability, and stability of these compounds in formulations still need to be addressed. Once these issues have been resolved, these compounds could be included as nutraceuticals and functional foods capable of increasing PON1 activity, thereby helping with the long-term prevention of atherosclerosis and other chronic ailments.

  7. The Search for Dietary Supplements to Elevate or Activate Circulating Paraoxonases

    Science.gov (United States)

    Lou-Bonafonte, José M.; Gabás-Rivera, Clara; Navarro, María A.; Osada, Jesús

    2017-01-01

    Low levels of paraoxonase 1 (PON1) have been associated with the development of several pathological conditions, whereas high levels have been shown to be anti-atherosclerotic in mouse models. These findings suggest that PON1 could be a good surrogate biomarker. The other members of the family, namely PON2 and PON3, the role of which has been much less studied, deserve more attention. This paper provides a systematic review of current evidence concerning dietary supplements in that regard. Preliminary studies indicate that the response to dietary supplements may have a nutrigenetic aspect that will need to be considered in large population studies or in clinical trials. A wide range of plant preparations have been found to have a positive action, with pomegranate and some of its components being the best characterized and Aronia melanocarpa one of the most active. Flavonoids are found in the composition of all active extracts, with catechins and genistein being the most promising agents for increasing PON1 activity. However, some caveats regarding the dose, length of treatment, bioavailability, and stability of these compounds in formulations still need to be addressed. Once these issues have been resolved, these compounds could be included as nutraceuticals and functional foods capable of increasing PON1 activity, thereby helping with the long-term prevention of atherosclerosis and other chronic ailments. PMID:28212288

  8. Contrasting genetic influence of PON 1 coding gene polymorphisms ...

    African Journals Online (AJOL)

    Nadia Youssef Sadek Morcos

    2015-03-31

    Mar 31, 2015 ... toxicity primarily by inhibiting the enzyme acetylcholinesterase. (AChE) [1]. ... 3. Methods. DNA was extracted from whole blood using a QIAamp Blood .... activity. It is not clear whether this is because of a decreased stability of ...

  9. Effect of moxifloxacin on oxidative stress, paraoxonase-1 (PON1 ...

    African Journals Online (AJOL)

    oxidative stress in patients with multiple drug-resistant tuberculosis (MDR-TB). Methods: A total ofof ... seriously affects the quality of life and prognosis. [6]. ... balance between pro-oxidants and antioxidant ..... original work is properly credited.

  10. Members of the Agency

    International Nuclear Information System (INIS)

    2007-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.63) is Palau which deposited its Instrument of Acceptance of the Statute on 2 March 2007. The Attachment hereto shows the dates on which the present 144 Member States became Members [fr

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    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.63) is Palau which deposited its Instrument of Acceptance of the Statute on 2 March 2007. The Attachment hereto shows the dates on which the present 144 Member States became Members [es

  12. Glued structural members

    Science.gov (United States)

    Russell C. Moody; Jen Y. Liu

    1999-01-01

    Glued structural members are manufactured in a variety of configurations. Structural composite lumber (SCL) products consist of small pieces of wood glued together into sizes common for solid-sawn lumber. Glued-laminated timber (glulam) is an engineered stress-rated product that consists of two or more layers of lumber in which the grain of all layers is oriented...

  13. CERN welcomes new members

    Science.gov (United States)

    2017-08-01

    Lithuania is on course to become an associate member of CERN, pending final approval by the Lithuanian parliament. Associate membership will allow representatives of the Baltic nation to take part in meetings of the CERN Council, which oversees the Geneva-based physics lab.

  14. DUBNA: Member States

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    The political upheaval in what was the Soviet Union was reflected in an Extraordinary Plenipotentiaries Committee of Joint Institute for Nuclear Research (JINR) Member States, held in Dubna, near Moscow, on 10-13 December, with representatives of eleven sovereign republics of the former Soviet State taking part

  15. Supporting Members and Friends

    Science.gov (United States)

    2005-10-01

    Thank you! Over the past year, AGU has received 12,104 gifts, both large and small, from members and friends. The Union has also received corporate contributions, National Science Foundation grants, and support from the National Oceanographic Partnership Program and National Association of Geoscience Teachers. Together their generosity has benefited AGU non revenue producing programs that are critical to our science and the future health of the Union. The following list gratefully acknowledges annual gifts of $100 or more and cumulative giving of $5,000 or more. The 1919 Society ($100,000 or more) and Benefactors ($5,000-$99,999) recognize single major gifts and cumulative contributions. Three circles acknowledge annual giving: President's Circle ($1,000 or more), Leadership Circle ($200-$999), and Supporters Circle ($100-$199). Supporting Life Members, who contribute a one-time gift of $1,200 in addition to lifetime dues, are among our most loyal Supporters.

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  19. [Comment on] BOSP members

    Science.gov (United States)

    Richman, Barbara T.

    The new Board on Ocean Science and Policy (BOSP) (Eos, June 7, 1983, p. 402) met for the first time on May 4. John B. Slaughter, former director of the National Science Foundation and now chancellor of the University of Maryland in College Park, is the board's chairman. Other board members are D. James Baker, Jr. (University of Washington, Seattle); Kirk Bryan (Geophysical Fluid Dynamics Laboratory, Princeton University); John P. Craven (University of Hawaii); Charles L. Drake (Dartmouth College); Paul M. Fye (Woods Hole Oceanographic Institution); Edward D. Goldberg (Scripps Institution of Oceanography); G. Ross Heath (Oregon State University); Judith T. Kildow (Massachusetts Institute of Technology); John A. Knauss (University of Rhode Island); James J. McCarthy (Museum of Comparative Zoology, Harvard University); H. William Menard (Scripps Institution of Oceanography); C. Barry Raleigh (Lamont-Doherty Geological Observatory); Roger Revelle (University of California, San Diego); David A. Ross (Woods Hole Oceanographic Institution); Brian J. Rothschild (University of Maryland); William M. Sackett (University of South Florida); John H. Steele (Woods Hole Oceanographic Institution); and Carl Wunsch (MIT). Wallace Broecker (Lamont-Doherty Geological Observatory), an original board member, resigned after the first meeting. Broecker told Eos that combining the science and policy boards resulted in a new board whose mission is too broad. A new board member will be appointed in Broecker's place

  20. The Members of the Agency

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    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.63) is Palau which deposited its Instrument of Acceptance of the Statute on 2 March 2007. The Attachment hereto shows the dates on which the present 144 Member States became Members

  1. The Members of the Agency

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    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.67) is Cambodia which deposited its Instrument of Acceptance of the Statute on 23 November 2009. The Attachment hereto shows the dates on which the present 151 Member States became Members

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    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.64) is Nepal which deposited its Instrument of Acceptance of the Statute on 8 July 2008. The Attachment hereto shows the dates on which the present 145 Member States became Members

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    The new Members since the last list of Member States was issued (INFCIRC/2/Rev.61) are Belize, Mozambique and Malawi, which deposited their Instruments of Acceptance of the Statute on 31 March 2006, 18 September 2006 and 2 October 2006 respectively. The Attachment hereto shows the dates on which the present 142 Member States became Members

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    The new Members since the last list of Member States was issued (INFCIRC/2/Rev.66) are Bahrain, Burundi, Congo and Lesotho which deposited their Instruments of Acceptance of the Statute on 23 June 2009, 24 June 2009, 15 July 2009 and 13 July 2009, respectively. The Attachment hereto shows the dates on which the present 150 Member States became Members

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    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.62) is Montenegro which deposited its Instrument of Acceptance of the Statute on 30 October 2006. The Attachment hereto shows the dates on which the present 143 Member States became Members

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    The new Members since the last list of Member States was issued (INFCIRC/2/Rev.66) are Bahrain, Burundi, Congo and Lesotho which deposited their Instruments of Acceptance of the Statute on 23 June 2009, 24 June 2009, 15 July 2009 and 13 July 2009, respectively. The Attachment hereto shows the dates on which the present 150 Member States became Members [ru

  7. The Members of the Agency

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    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.67) is Cambodia which deposited its Instrument of Acceptance of the Statute on 23 November 2009. The Attachment hereto shows the dates on which the present 151 Member States became Members [fr

  8. The Members of the Agency

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    The new Members since the last list of Member States was issued (INFCIRC/2/Rev.61) are Belize, Mozambique and Malawi, which deposited their Instruments of Acceptance of the Statute on 31 March 2006, 18 September 2006 and 2 October 2006 respectively. The Attachment hereto shows the dates on which the present 142 Member States became Members [fr

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    The new Members since the last list of Member States was issued (INFCIRC/2/Rev.66) are Bahrain, Burundi, Congo and Lesotho which deposited their Instruments of Acceptance of the Statute on 23 June 2009, 24 June 2009, 15 July 2009 and 13 July 2009, respectively. The Attachment hereto shows the dates on which the present 150 Member States became Members [fr

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    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.65) is the Sultanate of Oman which deposited its Instrument of Acceptance of the Statute on 5 February 2009. The Attachment hereto shows the dates on which the present 146 Member States became Members [fr

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    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.59) is the Islamic Republic of Mauritania, which deposited the instrument of acceptance of the Statute on 23 November 2004. The Attachment hereto shows the dates on which the present 138 Member States became Members

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    The new Members since the last list of Member States was issued (INFCIRC/2/Rev.66) are Bahrain, Burundi, Congo and Lesotho which deposited their Instruments of Acceptance of the Statute on 23 June 2009, 24 June 2009, 15 July 2009 and 13 July 2009, respectively. The Attachment hereto shows the dates on which the present 150 Member States became Members [es

  13. The Members of the Agency

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    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.67) is Cambodia which deposited its Instrument of Acceptance of the Statute on 23 November 2009. The Attachment hereto shows the dates on which the present 151 Member States became Members [es

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    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.60) is Chad, which deposited the instrument of acceptance of the Statute on 2 November 2005. The Attachment hereto shows the dates on which the present 139 Member States became Members

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    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.65) is the Sultanate of Oman which deposited its Instrument of Acceptance of the Statute on 5 February 2009. The Attachment hereto shows the dates on which the present 146 Member States became Members [es

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    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.58) is Kyrgyzstan, which deposited the instrument of acceptance of the Statute on 10 September 2003. The list shows the dates on which the present 137 Member States became Members

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    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.65) is the Sultanate of Oman which deposited its Instrument of Acceptance of the Statute on 5 February 2009. The Attachment hereto shows the dates on which the present 146 Member States became Members

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    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.67) is Cambodia which deposited its Instrument of Acceptance of the Statute on 23 November 2009. The Attachment hereto shows the dates on which the present 151 Member States became Members [ru

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    2015-01-01

    Summer is here, enjoy our offers for the aquatic parcs! Walibi : Tickets "Zone terrestre": 21,50 € instead of 27 €. Access to Aqualibi: 5 € instead of 6 € on presentation of your SA member ticket. Free for children (3-11 years old) before 12:00 p.m. Free for children under 3, with limited access to the attractions. Car park free. * * * * * Aquaparc : Day ticket: – Children: 33 CHF instead of 39 CHF – Adults : 33 CHF instead of 49 CHF Bonus! Free for children under 5.

  1. Offers for our members

    CERN Multimedia

    Staff Association

    2016-01-01

    Summer is here, enjoy our offers for the aquatic parcs! Walibi : Tickets "Zone terrestre": 23 € instead of 29 €. Access to Aqualibi: 5 € instead of 6 € on presentation of your SA member ticket. Free for children (3-11 years old) before 12:00 p.m. Free for children under 3, with limited access to the attractions. Car park free. * * * * * Aquaparc : Day ticket: – Children: 33 CHF instead of 39 CHF – Adults : 33 CHF instead of 49 CHF Bonus! Free for children under 5.

  2. Cryogenic support member

    International Nuclear Information System (INIS)

    Niemann, R.C.; Gonczy, J.D.; Nicol, T.H.

    1987-01-01

    A cryogenic support member is described for restraining a cryogenic system comprising; a rod having a depression at a first end. The rod is made of non-metallic material. The non-metallic material has an effectively low thermal conductivity; a metallic plug; and a metallic sleeve. The plug and the sleeve are shrink-fitted to the depression in the rod and assembled thereto such that the plug is disposed inside the depression of the rod. The sleeve is disposed over the depression in the rod and the rod is clamped therebetween. The shrink-fit clamping the rod is generated between the metallic plug and the metallic sleeve

  3. Thermal effects in concrete members

    International Nuclear Information System (INIS)

    Kar, A.K.

    1977-01-01

    When subjected to temperature changes and restrained from free movement, a member develops stresses. Restrained members are sometimes assumed to act independently of other members. A method of analysis and design for thermal stresses in such members is provided. The method of analysis, based on the ultimate strength concept, greatly reduces the computational efforts for determining thermal effects in concrete members. Available charts and tables and the recommendations given herein simplify the design. (Auth.)

  4. Offers for our members

    CERN Multimedia

    Staff Association

    2013-01-01

    The Courir shops propose the following offer: 15% discount on all articles (not on sales) in the Courir shops (Val Thoiry, Annemasse and Neydens) and 5% discount on sales upon presentation of your Staff Association membership card and an identity card before payment. Summer is here, enjoy our offers for the aquatic parcs! Walibi : Tickets "Zone terrestre": 21 € instead of 26 €. Access to Aqualibi: 5 € instead of 8 € on presentation of your SA member ticket. Free for children (3-11 years old) before 12 h 00. Free for children under 3, with limited access to the attractions. Car park free. * * * * * Aquaparc : Day ticket: – Children: 30 CHF instead of 39 CHF – Adults : 36 CHF instead of 49 CHF Bonus! Free for children under 5.

  5. Offers for our members

    CERN Multimedia

    Association du personnel

    2013-01-01

    La banque LCL propose aux membres de l’Association du personnel les avantages suivants : – Un barème Privilège sur le Prêt immobilier – Des avantages tarifaires sur l’épargne, notamment l’assurance-vie. – Un taux préférentiel de prêt à la consommation. En outre, jusqu’au 30 septembre 2013, elle offre 50€ à tous les nouveaux clients, membres de l'Association du personnel. Summer is here, enjoy our offers for the aquatic parcs! Tickets "Zone terrestre" : 21 € instead of de 26 €. Access to Aqualibi : 5 euros instead of 8 euros on presentation of your SA member ticket. Free for children (3-11 years old) before 12 h 00. Free for children under 3, with limited access to the attractions. Free car park. * * * * * * * Full day ticket: – Children : 30 CHF instead of 39 CHF &...

  6. Offers for our members

    CERN Multimedia

    Staff Association

    2013-01-01

    The warm weather arrives, it's time to take advantage of our offers Walibi and Aquapark! Walibi : Tickets "Zone terrestre": 21 € instead of 26 € Access to Aqualibi: 5 € instead of 8 € on presentation of your SA member ticket. Free for children (3-11 years old) before 12 h 00. Free for children under 3, with limited access to the attractions. Car park free. * * * * * Aquaparc : Half-day ticket (5 hours): – Children: 26 CHF instead of 35 CHF – Adults : 32 CHF instead of 43 CHF Day ticket: – Children: 30 CHF instead of 39 CHF – Adults : 36 CHF instead of 49 CHF Free for children under 5.

  7. The Members of the Agency

    International Nuclear Information System (INIS)

    2003-01-01

    The document lists the 135 Member States of the Agency as of 19 March 2003. The new Member since the last issue of the list (INFCIRC/2/56) is the Republic of Honduras. The dates on which the present 135 Member States became Members are given in an Attachment. It also shows the States whose application for membership of the Agency has been approved by the General Conference but which has not yet deposited an instrument of acceptance of the Statute

  8. The Members of the Agency

    International Nuclear Information System (INIS)

    1999-01-01

    The document lists the 130 Member States of the Agency as of 1 December 1999. The new Member since the last issue of the list (INFCIRC/2/52) is Angola. The dates on which the present 130 Member States became Members, and the state Honduras) whose application for membership of the Agency has been approved by the General Conference but which has not yet deposited an instrument of acceptance of the Statute are given in an Attachment

  9. The Members of the Agency

    International Nuclear Information System (INIS)

    2002-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.55) is the Republic of Botswana, which deposited the instrument of acceptance of the Statute on 20 March 2002. The Attachment hereto shows the dates on which the present 134 Member States became Members. It also shows the State whose application for membership of the Agency has been approved by the General Conference, but which has not yet deposited an instrument of acceptance of the Statute

  10. The Members of the Agency

    International Nuclear Information System (INIS)

    2001-01-01

    The document lists the 132 Member States of the Agency as of 1 June 2001. The new Members since the last issue of the list (INFCIRC/2/53) are Central African Republic and Azerbaijan. The dates on which the present 132 Member States became Members are given in an Attachment. It also shows the States whose application for membership of the Agency has been approved by the General Conference but which has not yet deposited an instrument of acceptance of the Statute

  11. The Members of the Agency

    International Nuclear Information System (INIS)

    2012-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.69) is the Commonwealth of Dominica, which deposited its instrument of acceptance of the Statute on 17 February 2012. The Attachment hereto shows the dates on which the present 153 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government

  12. The Members of the Agency

    International Nuclear Information System (INIS)

    2012-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.70) is Papua New Guinea, which deposited its instrument of acceptance of the Statute on 4 April 2012. The Attachment hereto shows the dates on which the present 154 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government

  13. The Members of the Agency

    International Nuclear Information System (INIS)

    2012-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.69) is the Commonwealth of Dominica, which deposited its instrument of acceptance of the Statute on 17 February 2012. The Attachment hereto shows the dates on which the present 153 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government [es

  14. The Members of the Agency

    International Nuclear Information System (INIS)

    2013-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.74) is Swaziland, which deposited its instrument of acceptance of the Statute on 15 February 2013. The Attachment hereto shows the dates on which the present 159 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government

  15. The Members of the Agency

    International Nuclear Information System (INIS)

    2012-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.71) is Rwanda, which deposited its instrument of acceptance of the Statute on 4 September 2012. The Attachment hereto shows the dates on which the present 155 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government

  16. The Members of the Agency

    International Nuclear Information System (INIS)

    2011-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.68) is the Lao People's Democratic Republic which deposited its instrument of acceptance of the Statute on 4 November 2011. The Attachment hereto shows the dates on which the present 152 Member States deposited instruments of ratification or acceptance of the Statue with the depositary Government [fr

  17. The Members of the Agency

    International Nuclear Information System (INIS)

    2012-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.73) is Trinidad and Tobago, which deposited its instrument of acceptance of the Statute on 9 November 2012. The Attachment hereto shows the dates on which the present 158 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government [fr

  18. The Members of the Agency

    International Nuclear Information System (INIS)

    2012-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.70) is Papua New Guinea, which deposited its instrument of acceptance of the Statute on 4 April 2012. The Attachment hereto shows the dates on which the present 154 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government [ru

  19. Family members' experiences of autopsy

    NARCIS (Netherlands)

    Oppewal, F; Meyboom-de Jong, B

    Background. The experiences of family members will teach us how to handle an autopsy, the ultimate quality assessment tool. Objective. The aim of this study was to determine surviving family members' experience of autopsy. Method. Seven GPs were asked to approach surviving family members of

  20. The Members of the Agency

    International Nuclear Information System (INIS)

    2014-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.76) is Brunei Darussalam, which deposited its instrument of acceptance of the Statute on 18 February 2014. The Attachment hereto shows the dates on which the present 162 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government [fr

  1. The Members of the Agency

    International Nuclear Information System (INIS)

    2012-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.70) is Papua New Guinea, which deposited its instrument of acceptance of the Statute on 4 April 2012. The Attachment hereto shows the dates on which the present 154 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government [fr

  2. The Members of the Agency

    International Nuclear Information System (INIS)

    2012-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.71) is Rwanda, which deposited its instrument of acceptance of the Statute on 4 September 2012. The Attachment hereto shows the dates on which the present 155 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government [fr

  3. The Members of the Agency

    International Nuclear Information System (INIS)

    2012-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.69) is the Commonwealth of Dominica, which deposited its instrument of acceptance of the Statute on 17 February 2012. The Attachment hereto shows the dates on which the present 153 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government [fr

  4. The members of the Agency

    International Nuclear Information System (INIS)

    1993-01-01

    The 42nd revision of INFCIRC/2 lists the 113 Member States of the International Atomic Energy Agency as of 1 January 1993. It includes Slovenia as a new Member State as of 21 September 1992, Cambodia replaces the former name ''Democratic Kampuchea'' and Czechoslovakia was deleted as it ceased to be a member of the Agency as of 1 January 1993 (INFCIRC/417)

  5. The Members of the Agency

    International Nuclear Information System (INIS)

    2011-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.68) is the Lao People's Democratic Republic which deposited its instrument of acceptance of the Statute on 4 November 2011. The Attachment hereto shows the dates on which the present 152 Member States deposited instruments of ratification or acceptance of the Statue with the depositary Government [es

  6. The Members of the Agency

    International Nuclear Information System (INIS)

    2012-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.73) is Trinidad and Tobago, which deposited its instrument of acceptance of the Statute on 9 November 2012. The Attachment hereto shows the dates on which the present 158 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government [es

  7. The Members of the Agency

    International Nuclear Information System (INIS)

    2012-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.70) is Papua New Guinea, which deposited its instrument of acceptance of the Statute on 4 April 2012. The Attachment hereto shows the dates on which the present 154 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government [es

  8. The Members of the Agency

    International Nuclear Information System (INIS)

    2012-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.71) is Rwanda, which deposited its instrument of acceptance of the Statute on 4 September 2012. The Attachment hereto shows the dates on which the present 155 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government [es

  9. The Members of the Agency

    International Nuclear Information System (INIS)

    2014-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.76) is Brunei Darussalam, which deposited its instrument of acceptance of the Statute on 18 February 2014. The Attachment hereto shows the dates on which the present 162 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government [es

  10. The Members of the Agency

    International Nuclear Information System (INIS)

    2012-01-01

    The new Members since the last list of Member States was issued (INFCIRC/2/Rev.72) are Fiji and Togo, which deposited their instruments of acceptance of the Statute on 2 November 2012 and 1 November 2012, respectively. The Attachment hereto shows the dates on which the present 157 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government

  11. The Members of the Agency

    International Nuclear Information System (INIS)

    2014-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.76) is Brunei Darussalam, which deposited its instrument of acceptance of the Statute on 18 February 2014. The Attachment hereto shows the dates on which the present 162 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government

  12. The Members of the Agency

    International Nuclear Information System (INIS)

    2012-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.73) is Trinidad and Tobago, which deposited its instrument of acceptance of the Statute on 9 November 2012. The Attachment hereto shows the dates on which the present 158 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government

  13. The Members of the Agency

    International Nuclear Information System (INIS)

    2011-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.68) is the Lao People's Democratic Republic which deposited its instrument of acceptance of the Statute on 4 November 2011. The Attachment hereto shows the dates on which the present 152 Member States deposited instruments of ratification or acceptance of the Statue with the depositary Government

  14. The Members of the Agency

    International Nuclear Information System (INIS)

    2012-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.71) is Rwanda, which deposited its instrument of acceptance of the Statute on 4 September 2012. The Attachment hereto shows the dates on which the present 155 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government [ru

  15. The Members of the Agency

    International Nuclear Information System (INIS)

    2012-01-01

    The new Members since the last list of Member States was issued (INFCIRC/2/Rev.72) are Fiji and Togo, which deposited their instruments of acceptance of the Statute on 2 November 2012 and 1 November 2012, respectively. The Attachment hereto shows the dates on which the present 157 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government [ru

  16. The Members of the Agency

    International Nuclear Information System (INIS)

    2012-01-01

    The new Members since the last list of Member States was issued (INFCIRC/2/Rev.72) are Fiji and Togo, which deposited their instruments of acceptance of the Statute on 2 November 2012 and 1 November 2012, respectively. The Attachment hereto shows the dates on which the present 157 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government [fr

  17. The Members of the Agency

    International Nuclear Information System (INIS)

    1999-01-01

    The document lists the 129 Member States of the Agency as of 1 June 1999. The new Member since the last issue of the list (INFCIRC/2/51) is Benin. The dates on which the present 129 states became Members, and the state (Honduras) whose application for membership of the Agency has been recommended by the Board of Governors to be considered at the 43rd session of the General Conference are given in an Attachment

  18. The Members of the Agency

    International Nuclear Information System (INIS)

    2012-01-01

    The new Members since the last list of Member States was issued (INFCIRC/2/Rev.72) are Fiji and Togo, which deposited their instruments of acceptance of the Statute on 2 November 2012 and 1 November 2012, respectively. The Attachment hereto shows the dates on which the present 157 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government [es

  19. The Members of the Agency

    International Nuclear Information System (INIS)

    1995-01-01

    The new member since the last list of Member States of the Agency was issued (INFCIRC/2/Rev.44) is Yemen. The Attachment hereto shows the dates on which the 122 States became members of the Agency, as well as the State whose application for membership of the Agency was approved by the General Conference, but which has not yet deposited an instrument of acceptance of the Statute

  20. The Members of the Agency

    International Nuclear Information System (INIS)

    2014-01-01

    The new Members since the last list of Member States was issued (INFCIRC/2/Rev.75) are San Marino and the Bahamas, which deposited their instruments of acceptance of the Statute on 25 November 2013 and 7 January 2014, respectively. The Attachment hereto shows the dates on which the present 161 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government [es

  1. The members of the Agency

    International Nuclear Information System (INIS)

    1994-01-01

    The new members since the last list of Member States of the Agency was issued (INFCIRC/2/Rev.42) are: Armenia, Coratia, the Czech Republic, Lithuania, the Marshall Islands, the Slovak Republic and Uzbekistan. The Attachment to the circular shows the dates on which the 120 States became members of the Agency, as well as those States whose application for membership of the Agency was approved by the General Conference, but who have not yet deposited an instrument of acceptance of the Statute

  2. The Members of the Agency

    International Nuclear Information System (INIS)

    1998-01-01

    The document lists the 128 Member States of the Agency as of 18 September 1998. The new Member since the last issue of the list (INFCIRC/2/50) is Burkina Faso. In an attachment the dates on which the present 128 states became Members, and the state (Benin) whose application for membership of the Agency has been recommended by the Board of Governors to be considered at the 42nd session of the General Conference are given

  3. The Members of the Agency

    International Nuclear Information System (INIS)

    2014-01-01

    The new Members since the last list of Member States was issued (INFCIRC/2/Rev.75) are San Marino and the Bahamas, which deposited their instruments of acceptance of the Statute on 25 November 2013 and 7 January 2014, respectively. The Attachment hereto shows the dates on which the present 161 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government

  4. The Members of the Agency

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-02-13

    The new member since the last list of Member States of the Agency was issued (INFCIRC/2/Rev.44) is Yemen. The Attachment hereto shows the dates on which the 122 States became members of the Agency, as well as the State whose application for membership of the Agency was approved by the General Conference, but which has not yet deposited an instrument of acceptance of the Statute.

  5. The members of the Agency

    International Nuclear Information System (INIS)

    1998-01-01

    The document lists the 127 Member States of the Agency as of 1 January 1998. The new Members since the last issue of of the list (INFCIRC/2/49) are Malta and the Republic of Moldova. In an attachment are given the dates on which the present 127 states become Members, the state (Burkina Faso) whose application for membership of the Agency has been approved by the General Conference but which has not deposited an instrument of acceptance of the Statute

  6. The members of the Agency

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-01-15

    The document lists the 127 Member States of the Agency as of 1 January 1998. The new Members since the last issue of of the list (INFCIRC/2/49) are Malta and the Republic of Moldova. In an attachment are given the dates on which the present 127 states become Members, the state (Burkina Faso) whose application for membership of the Agency has been approved by the General Conference but which has not deposited an instrument of acceptance of the Statute.

  7. The Members of the Agency

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-18

    The document lists the 128 Member States of the Agency as of 18 September 1998. The new Member since the last issue of the list (INFCIRC/2/50) is Burkina Faso. In an attachment the dates on which the present 128 states became Members, and the state (Benin) whose application for membership of the Agency has been recommended by the Board of Governors to be considered at the 42nd session of the General Conference are given

  8. The Members of the Agency

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-06-16

    The document lists the 129 Member States of the Agency as of 1 June 1999. The new Member since the last issue of the list (INFCIRC/2/51) is Benin. The dates on which the present 129 states became Members, and the state (Honduras) whose application for membership of the Agency has been recommended by the Board of Governors to be considered at the 43rd session of the General Conference are given in an Attachment.

  9. The Members of the Agency

    International Nuclear Information System (INIS)

    2014-01-01

    The new Members since the last list of Member States was issued (INFCIRC/2/Rev.75) are San Marino and the Bahamas, which deposited their instruments of acceptance of the Statute on 25 November 2013 and 7 January 2014, respectively. The Attachment hereto shows the dates on which the present 161 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government [fr

  10. The Members of the Agency

    International Nuclear Information System (INIS)

    2001-01-01

    The new Members since the last list of Member States was issued (INFCIRC/2/Rev.54) are the Republic of Tajikistan, which deposited the instrument of acceptance of the Statute on 10 September 2001 and the Federal Republic of Yugoslavia, which deposited the instrument of acceptance of the Statute on 31 October 2001. The Attachment hereto shows the dates on which the present 133 Member States became Members. It also shows the States whose applications for membership of the Agency have been approved by the General Conference, but which have not yet deposited an instrument of acceptance of the Statute

  11. The members of the Agency

    International Nuclear Information System (INIS)

    1996-01-01

    The document lists the 124 Member States of the Agency as of 1 September 1996. The new Member since the last issue of the list (INFCIRC/2/Rev.47) is Georgia. In an attachment are given the dates on which the 124 Member States became Members, the State (Latvia) whose application for membership of the Agency has been approved by the General Conference but which has not yet deposited an instrument of acceptance of the Statute and the State (Republic of Moldova) whose application for membership has been recommended by the Board of Governors for approval by the General Conference

  12. The members of the Agency

    International Nuclear Information System (INIS)

    1996-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.46) is Bosnia and Herzegovina. The Attachment hereto shows the dates on which the present 123 Member States became Members. It also shows the States whose applications for membership of the Agency have been approved by the General Conference but which have not yet deposited an instrument of acceptance of the Statute and the State whose application for membership has been recommended by the Board of Governors for approval by the General Conference

  13. The Members of the Agency

    International Nuclear Information System (INIS)

    1995-01-01

    No new Member has joined the Agency since the last list of Member States was issued (INFCIRC/2/Rev.45). The Attachment hereto shows the dates on which the present 122 Member States became Members. It also shows the State whose application for membership of the Agency has been approved by the General Conference but which has not yet deposited an instrument of acceptance of the Statute and the States whose applications for membership have been recommended by the Board of Governors for approval by the General Conference

  14. The Members of the Agency

    International Nuclear Information System (INIS)

    2003-01-01

    The document lists the 136 Member States of the Agency as of 6 May 2003. The new Members since the last issue of the list (INFCIRC/2/57) are Eritrea and the Republic of Seychelles. Cambodia withdrew from the Agency with effect from 26 March 2003. The dates on which the present 136 Member States became Members are given in an Attachment. It also shows the States whose application for membership of the Agency has been approved by the General Conference but which has not yet deposited an instrument of acceptance of the Statute

  15. The members of the Agency

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-09-10

    The document lists the 124 Member States of the Agency as of 1 September 1996. The new Member since the last issue of the list (INFCIRC/2/Rev.47) is Georgia. In an attachment are given the dates on which the 124 Member States became Members, the State (Latvia) whose application for membership of the Agency has been approved by the General Conference but which has not yet deposited an instrument of acceptance of the Statute and the State (Republic of Moldova) whose application for membership has been recommended by the Board of Governors for approval by the General Conference.

  16. The Members of the Agency

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-11

    No new Member has joined the Agency since the last list of Member States was issued (INFCIRC/2/Rev.45). The Attachment hereto shows the dates on which the present 122 Member States became Members. It also shows the State whose application for membership of the Agency has been approved by the General Conference but which has not yet deposited an instrument of acceptance of the Statute and the States whose applications for membership have been recommended by the Board of Governors for approval by the General Conference.

  17. The members of the Agency

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-26

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.46) is Bosnia and Herzegovina. The Attachment hereto shows the dates on which the present 123 Member States became Members. It also shows the States whose applications for membership of the Agency have been approved by the General Conference but which have not yet deposited an instrument of acceptance of the Statute and the State whose application for membership has been recommended by the Board of Governors for approval by the General Conference.

  18. Materials Delivered by Member States

    International Nuclear Information System (INIS)

    1969-01-01

    In this document the Director General is reporting to the Members of the Agency, under Article IX. G of the Statute, the quantities of materials delivered by Members up to 30 June 1969 in compliance with requests the Agency had made under Article IX. D

  19. Materials Delivered by Member States

    International Nuclear Information System (INIS)

    1975-01-01

    In this document the Director General is reporting to the Members of the Agency, under Article IX. G of the Statute, the quantities of materials which Members had delivered up to 30 June 1975, in compliance with requests the Agency had made under Article IX. D

  20. Materials Delivered by Member States

    International Nuclear Information System (INIS)

    1974-01-01

    In this document the Director General is reporting to the Members of the Agency, under Article IX. G of the Statute, the quantities of materials which Members had delivered up to 31 March 1974, in compliance with requests the Agency had made under Article IX. D

  1. Materials Delivered by Member States

    International Nuclear Information System (INIS)

    1971-01-01

    In this document the Director General is reporting to the Members of the Agency, under Article IX. G of the Statute, the quantities of materials which Members had delivered up to the end of 1970, in compliance with requests the Agency had made under Article IX. D

  2. Materials Delivered by Member States

    International Nuclear Information System (INIS)

    1973-01-01

    In this document the Director General is reporting to the Members of the Agency, under Article IX. G of the Statute, the quantities of materials which Members had delivered up to the end of 1972, in compliance with requests the Agency had made under Article IX. D

  3. Materials Delivered by Member States

    International Nuclear Information System (INIS)

    1972-01-01

    In this document the Director General is reporting to the Members of the Agency, under Article IX. G of the Statute, the quantities of materials which Members had delivered up to the end of 1971, in compliance with requests the Agency had made under Article IX. D

  4. Working with Difficult Group Members.

    Science.gov (United States)

    Kottler, Jeffrey A.

    1994-01-01

    Describes types of group members who are challenging in group settings including entitled, manipulative, and character-disordered clients. Provides suggestions for working with these group members, either as isolated cases or as homogenous populations, emphasizing the protection of other clients' rights. Includes 31 references. (Author/CRR)

  5. The Members of the Agency

    International Nuclear Information System (INIS)

    1997-01-01

    The document lists the 125 Member States of the Agency as of 1 September 1997. The new Member since the last issue of the list (INFCIRC/2/Rev.48) is Latvia. In an Attachment are given the dates on which the present 125 States became Members, the State (Republic of Moldova) whose application for membership of the Agency has been approved by the General Conference but which has not yet deposited an instrument of acceptance of the Statute and the States (Malta and Burkina Faso) whose applications for membership have been recommended by the Board of Governors for approval by the General Conference

  6. The Members of the Agency

    International Nuclear Information System (INIS)

    1994-01-01

    The new members since the last list of Member States of the Agency was issued (INFCIRC/2/Rev.43) are: Kazakhstan and the former Yugoslav Republic of Macedonia. The Democratic People's Republic of Korea withdrew from membership of the Agency as of 13 June 1994. The Attachment hereto shows the dates on which the 121 States became members of the Agency, as well as those States whose application for membership of the Agency was approved by the General Conference, but who have not yet deposited an instrument of acceptance of the Statute

  7. The Members of the Agency

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-09-22

    The document lists the 125 Member States of the Agency as of 1 September 1997. The new Member since the last issue of the list (INFCIRC/2/Rev.48) is Latvia. In an Attachment are given the dates on which the present 125 States became Members, the State (Republic of Moldova) whose application for membership of the Agency has been approved by the General Conference but which has not yet deposited an instrument of acceptance of the Statute and the States (Malta and Burkina Faso) whose applications for membership have been recommended by the Board of Governors for approval by the General Conference.

  8. Thermal effects in concrete members

    International Nuclear Information System (INIS)

    Kar, A.K.

    1977-01-01

    The proposed method of analysis for concrete members subjected to temperature changes is consistent with the requirements of ultimate strength design. This also facilitates the provision of the same safety margin as for other loads. Due to cracks and creep in concrete, thermal stresses are nonlinear; they are dependent on the effective member stiffness, which in turn vary with the magnitude of loading. Therefore it is inconsistent to have an ultimate strength design in conjunction with an analysis based on the linear elastic theory. It is proposed that when the requirements of serviceability are met, the neutral axis corresponding to the ultimate load capacity conditions be considered for temperature-induced loadings. This conforms with the fact that the thermal load, because of creep and formation of cracks in the member, can be self-relieving as the failure load condition or ultimate capacity is approached. The maximum thermal load that can develop in dependent on the effective cross section of the member. Recommendations are made for determining the average effective member stiffness, which lies between the stiffness corresponding to the cracked (at ultimate condition) and the uncracked sections. In the proposed method, thermal stresses are not considered completely self-relieving. The stresses are considered simultaneously with stresses resulting from other causes. A step-by-step approach is presented for analysis and design of concrete members subjected to temperature changes

  9. Association of genetic polymorphisms of PON1 and CETP with the ...

    African Journals Online (AJOL)

    Behdokht Fathi Dizaji

    2018-01-17

    Jan 17, 2018 ... presence of metabolic syndrome; the effects of genotypes on their serum activity and .... stress may be a contributory factor, such as CVD, Alzheimer, MetS, ..... The authors frankly thank all of the patients and their family.

  10. Examination of plasma PON1 paraoxonase activity and genotype in Gulf War veterans

    Science.gov (United States)

    2017-10-01

    contribute to the risk for Gulf War Illness (GWI), as defined by the Centers for Disease Control and Prevention (CDC) and Kansas case definitions in...Disease Control and Prevention (CDC) and Kansas case definitions in a large sample of GW veterans. Specifically, we will: (1) determine the...models);  clinical interventions;  new business creation; and  other. 7. PARTICIPANTS & OTHER COLLABORATING ORGANIZATIONS What

  11. Burnout in Female Faculty Members.

    Science.gov (United States)

    Cassidy-Vu, Lisa; Beck, Keli; Moore, Justin B

    2017-04-01

    Despite approximately equal numbers of male and female medical school graduates, women are entering academic medicine at a lower rate than their male colleagues. Of those who do assume a faculty position, female faculty members report higher levels of burnout, often attributable to gender-specific difficulties in clinical expectations and maintenance of work-life balance. Many of these struggles are attributable to issues that are amenable to supportive policies, but these policies are inconsistent in their availability and practice. This commentary presents evidence for inconsistencies in the day-to-day experience of female faculty members, and proposes solutions for the mitigation of the challenges experienced more often by female faculty members with the goal of diversifying and strengthening academic medicine.

  12. Materials Delivered by Member States

    International Nuclear Information System (INIS)

    1966-01-01

    The information given in this document is divided into two parts. In part I the Director General is reporting to the Members of the Agency, under Article IX. G of the Statute, the quantities of materials delivered by Members up to 31 December 1965 in compliance with requests the Agency had made under Article IX. D. Part III contains information about materials which had not been delivered by 31 December but which had been allocated, in accordance with Article XI. F. 1 of the Statute, to approved Agency projects for which project arrangements were in force on that date

  13. Materials Delivered by Member States

    International Nuclear Information System (INIS)

    1965-01-01

    The information given in this document is divided into two parts. In part I the Director General is reporting to the Members of the Agency, under Article IX. G of the Statute, the quantities of materials delivered by Members up to 31 December 1964 in compliance with requests the Agency had made under Article IX. D. Part II contains information about materials which had not been delivered by 31 December but which had been allocated, in accordance with Article XI. F. 1 of the Statute, to approved Agency projects for which project arrangements were in force on that date

  14. Materials Delivered by Member States

    International Nuclear Information System (INIS)

    1968-01-01

    The information given in this document is divided into two parts. In part I the Director General is reporting to the Members of the Agency, under Article IX. G of the Statute, the quantities of materials delivered by Members up to 30 June 1968 in compliance with requests the Agency had made under Article IX,D. Part II contains information about materials which had not been delivered by 30 June 1968 but which had been allocated, in accordance with Article XI.F.I of the Statute, to approved Agency projects for which project arrangements were in force on that date

  15. ALA Salary Survey: Personal Members

    Science.gov (United States)

    American Libraries, 1971

    1971-01-01

    A survey of the members of the American Library Association revealed that the principal salary determinants are academic degree, type of employer and sex. The obvious differences in the earnings of men and women is not only found in the early experience years but any narrowing which does take place in the wage gap seems to take place at the…

  16. Slovenia joins IPPOG as member

    CERN Multimedia

    'marcelloni, claudia

    2018-01-01

    Slovenia became an official member of IPPOG on 19 April 2018. The MOU was signed by the head of Particle Physics Department at Jozef Stefan Institute representing Slovenia participation at IPPOG. Andrej Gorišek, country representative for Slovenia in IPPOG, brought the document to the meeting in Italy where IPPOG chairs signed it, confirming Slovenia membership to the collaboration.

  17. Understanding Heterogeneous Preferences of Cooperative Members

    NARCIS (Netherlands)

    Kalogeras, N.; Pennings, J.M.E.; Lans, van der I.A.; Garcia, P.; Dijk, van G.

    2009-01-01

    We study the heterogeneity in the preference structure of cooperative members. Using conjoint analysis the utility that members attach to intra-organizational and strategic attributes of their cooperative is elicited. Recognizing that members are not homogenous, a concomitant finitemixture

  18. Community Members Draw the Line

    Directory of Open Access Journals (Sweden)

    Gregory Freeland

    2014-06-01

    Full Text Available This study investigates whether a community-based task force’s redistricting plan in Ventura County, California, positively affected fair representation, social equity issues, community interests, and the electoral process. Examination and evaluation of the organizational strategies and collaborations involved in the task force’s redistricting process find that the Board of Supervisors districts that members of the community drew were successful in improving and maintaining fair representation. This finding is based on comparing supervisorial votes and policies with community members’ votes on state propositions and local measures, in addition to conducting interviews with task force members, politicians, and community activists. This study finds that citizen participation in governmental processes improves overall community health and political participation.

  19. Power reactors in member states

    International Nuclear Information System (INIS)

    1975-01-01

    This is the first issue of a periodical computer-based listing of civilian nuclear power reactors in the Member States of the IAEA, presenting the situation as of 1 April 1975. It is intended as a replacement for the Agency's previous annual publication of ''Power and Research Reactors in Member States''. In the new format, the listing contains more information about power reactors in operation, under construction, planned and shut down. As far as possible all the basic design data relating to reactors in operation have been included. In future these data will be included also for other power reactors, so that the publication will serve to give a clear picture of the technical progress achieved. Test and research reactors and critical facilities are no longer listed. Of interest to nuclear power planners, nuclear system designers, nuclear plant operators and interested professional engineers and scientists

  20. New offer for our members

    CERN Document Server

    Staff Association

    2018-01-01

    Evolution 2, your specialist for Outdoor Adventures Be it for a ski lesson, a parachute jump or for a mountain bike descent, come live an unforgettable experience with our outdoor specialists. Benefit from a 10 % discount on all activities: Offer is open to SA members and their family members living in the same household, upon presentation of the membership card. Offer available for all bookings made between 1 June 2018 and 30 May 2019. Offer available on all the Evoltion2 sites. A wide range of summer and winter activities. More information on http://evolution2.com/ Contact and reservation : +33 (0)4.50.02.63.35 management@evolution2.com

  1. Materials Delivered by Member States

    International Nuclear Information System (INIS)

    1962-01-01

    The information given in this document is divided into two parts. In part I the Director General is reporting to the Members of the Agency, under Article IX. G of the Statute, the quantities of materials delivered up to 30 September 1962 by Member States in compliance with requests the Agency has made under Article IX. D. Part II contains information about materials which have not yet been delivered but which have been allocated, in accordance with Article XI. F. 1 of the Statute, to approved Agency projects for which project agreements were in force on 30 September 1962. Reports on subsequent deliveries of materials and revised information about allocated but undelivered materials will be issued from time to time

  2. Communication Among Melanoma Family Members

    Science.gov (United States)

    Bowen, Deborah J; Albrecht, Terrance; Hay, Jennifer; Eggly, Susan; Harris-Wei, Julie; Meischke, Hendrika; Burke, Wylie

    2017-01-01

    Interventions to improve communication among family members may facilitate information flow about familial risk and preventive health behaviors. This is a secondary analysis of the effects of an interactive website intervention aimed at increasing communication frequency and agreement about health risk among melanoma families. Participants were family units, consisting of one family member with melanoma identified from a previous research study (the case) and an additional first degree relative and a parent of a child 0–17. Family triads were randomized to receive access to the website intervention or to serve as control families. Family communication frequency and agreement about melanoma prevention behaviors and beliefs were measured at baseline and again at one year post randomization. Intervention participants of all three types significantly increased the frequency of communication to their first degree relatives (Parents, siblings, children; range =14–18 percentage points; all pcommunication about cancer risk. PMID:28248624

  3. New support line for members

    Science.gov (United States)

    AGU has recently established a new customer "support line"—solutions@agu.org—as the point of contact on AGU's staff for members and other individual constituents who have not been able to resolve issues or get questions answered promptly or to their satisfaction through customary channels.Over the past year, there have been many changes at AGU. Unfortunately—and perhaps as a result of these changes—communication with members and individual constituents has suffered. Some individuals report, for example, that e-mail messages are not answered to their satisfaction, or in a timely manner. Instructions on AGU's Web site are unclear in some areas. Problems related specifically to the transition to electronic publishing are cropping up.

  4. Towards mobile staff members management

    Science.gov (United States)

    Encheva, Sylvia

    2017-07-01

    Todays project management requires a number of abilities which involve finding quick solutions to shortage of staff members with possession of specific qualities. When persons with team responsibilities are under pressure or due to various circumstances are unable to perform exhaustive search in databases, an interactive visualization tool can come in quite handy in finding good solutions unforeseen occurrences. In particular we propose application of selected graphs for facilitating mobile human resource management.

  5. Shielding member for thermonuclear device

    Energy Technology Data Exchange (ETDEWEB)

    Onozuka, Masanori

    1997-06-30

    In a thermonuclear device for shielding fast neutrons by shielding members disposed in a shielding vessel (vacuum vessel and structures such as a blanket disposed in the vacuum vessel), the shielding member comprises a large number of shielding wires formed fine and short so as to have elasticity. The shielding wires are sealed in a shielding vessel together with water, and when the width of the shielding vessel is changed, the shielding wires follow after the change of the width while elastically deforming in the shielding vessel, so that great stress and deformation are not formed thereby enabling to improve reliability. In addition, the length, the diameter and the shape of each of the shielding wires can be selected in accordance with the shielding space of the shielding vessel. Even if the shape of the shielding vessel is complicated, the shielding wires can be inserted easily. Accordingly, the filling rate of the shielding members can be changed easily. It can be produced more easily compared with a conventional spherical pebbles. It can be produced more easily than existent spherical shielding pebbles thereby enabling to reduce the production cost. (N.H.)

  6. 7 CFR 1425.19 - Member cooperatives.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Member cooperatives. 1425.19 Section 1425.19... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS COOPERATIVE MARKETING ASSOCIATIONS § 1425.19 Member cooperatives. A CMA may obtain loans or LDP's on behalf of a member cooperative when the member...

  7. International Focus: Highlighting APPA Members Worldwide

    Science.gov (United States)

    Glazner, Steve, Comp.

    2011-01-01

    While most APPA member institutions are located in the United States and Canada, there are also 45 of member institutions located internationally--from Australia and New Zealand to Southeast Asia to the Middle East to Europe. This article focuses on four of its international members: (1) American University of Kuwait (AUK); (2) American University…

  8. The Members of the Agency (French Edition)

    International Nuclear Information System (INIS)

    2013-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.74) is Swaziland, which deposited its instrument of acceptance of the Statute on 15 February 2013. The Attachment hereto shows the dates on which the present 159 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government

  9. The Members of the Agency (Spanish Edition)

    International Nuclear Information System (INIS)

    2013-01-01

    The new Member since the last list of Member States was issued (INFCIRC/2/Rev.74) is Swaziland, which deposited its instrument of acceptance of the Statute on 15 February 2013. The Attachment hereto shows the dates on which the present 159 Member States deposited instruments of ratification or acceptance of the Statute with the depositary Government

  10. Members of the LHC Resources Review Boards

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    Photo 01: Members of the LHCRRB visiting Point 2, hosting the ALICE experiment From l. to r. : W. Korda, Head of the VIP Office; P. Rimmer, CERN public relations, J. Seed, Member of the LHCRRB, J.-P. Revol, ALICE CERN Team Leader; J. Bartke, Member of the LHCRRB; F. Suransky, Member of the LHCRRB; J. Schukraft, Spokesperson, ALICE experiment and S. Molinari, VIP Office. Photo 02: Members of the LHC Resources Review Boards visiting the ALICE magnet at Point 2. L. to. r.: O. Dines-Hansen, H. Boggild, S. Irgens-Jensens, H.A. Gustafsson Photo 03: Members of the LHCRRB visiting Point 2, hosting the ALICE experiment From l. t to r.: J.Richter, Member of the LHCRRB; H. Gutbrod, Deputy Spokesperson, ALICE experiment; G. Paic, ALICE experiment; D. Muller, Member of the LHCRRB; P. Brau-Munzinger, ALICE experiment; R. Santo, Member of the LHCRRB, A. Van Rijn, Member of the LHCRRB; J. Engelen, Member of the LHCRRB.

  11. Finding Street Gang Members on Twitter

    OpenAIRE

    Balasuriya, Lakshika; Wijeratne, Sanjaya; Doran, Derek; Sheth, Amit

    2016-01-01

    Most street gang members use Twitter to intimidate others, to present outrageous images and statements to the world, and to share recent illegal activities. Their tweets may thus be useful to law enforcement agencies to discover clues about recent crimes or to anticipate ones that may occur. Finding these posts, however, requires a method to discover gang member Twitter profiles. This is a challenging task since gang members represent a very small population of the 320 million Twitter users. ...

  12. 7 CFR 1425.14 - Member business.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Member business. 1425.14 Section 1425.14 Agriculture... business. (a) At least 50 percent of a crop of an authorized commodity acquired by, or delivered to, a CMA... not be considered in determining the volume of member or nonmember business. ...

  13. Concerns raised over new EPA members

    Science.gov (United States)

    Gwynne, Peter

    2017-12-01

    The Trump administration has nominated three new members of the Environmental Protection Agency (EPA) who critics say are undermining laws and “pampering” the industries they are supposed to regulate.

  14. Energy outlooks of young members of parliament

    International Nuclear Information System (INIS)

    Tolonen, P.

    1999-01-01

    Pekka Tolonen Energy outlooks of young members of parliament The main theme is 'youth and nuclear energy'. This article presents opinions of young opinion leaders over energy policy and nuclear energy

  15. Member states buoy up beleagured EMBL

    CERN Multimedia

    Balter, M

    1999-01-01

    EMBL's governing council, made up of delegates from the lab's 16 member countries, agreed in principle to meet the costs of a multimillion-dollar pay claim, the result of a recent ruling by the ILO in Geneva (1 page).

  16. Israel, CERN’s new Member State

    CERN Multimedia

    Brice, Maximilien

    2014-01-01

    On Wednesday, 15 January 2014, the official Israeli Flag-raising Ceremony took place to mark the accession of Israel to Membership of CERN, bringing the Organization’s number of Member States to 21.

  17. Team Members | Center for Cancer Research

    Science.gov (United States)

    Our Team Members The Foregut Team includes experts in the diagnosis and treatment of the diseases listed below. Our clinical experience and active research offers patients the highest quality care in the setting of groundbreaking clinical trials.

  18. STRUCTURAL PERFORMANCE OF DEGRADED REINFORCED CONCRETE MEMBERS

    International Nuclear Information System (INIS)

    Braverman, J.I.; Miller, C.A.; Ellingwood, B.R.; Naus, D.J.; Hofmayer, C.H.; Bezler, P.; Chang, T.Y.

    2001-01-01

    This paper describes the results of a study to evaluate, in probabilistic terms, the effects of age-related degradation on the structural performance of reinforced concrete members at nuclear power plants. The paper focuses on degradation of reinforced concrete flexural members and shear walls due to the loss of steel reinforcing area and loss of concrete area (cracking/spalling). Loss of steel area is typically caused by corrosion while cracking and spalling can be caused by corrosion of reinforcing steel, freeze-thaw, or aggressive chemical attack. Structural performance in the presence of uncertainties is depicted by a fragility (or conditional probability of failure). The effects of degradation on the fragility of reinforced concrete members are calculated to assess the potential significance of various levels of degradation. The fragility modeling procedures applied to degraded concrete members can be used to assess the effects of degradation on plant risk and can lead to the development of probability-based degradation acceptance limits

  19. ADA members weigh in on critical issues.

    Science.gov (United States)

    Burgess, Karen; Ruesch, Jon D; Mikkelsen, Matthew C; Wagner, Karen Schaid

    2003-01-01

    Science, new technology, patient care, dental reimbursement and government regulations all affect today's dental practitioners. To find out more about how such challenges may affect current private practitioners, the American Dental Association conducted the 2000 Membership Needs and Opinions Survey. A questionnaire was sent to 6,310 ADA members in January 2000 with follow-up mailings in February, March and April 2000. Data collection was completed in July 2000. The survey included questions on critical professional issues, and on perceptions of the ADA and ADA priorities. A total of 3,558 completed surveys were received for an adjusted response rate of 59.5 percent. Members rated the identified issues' level of importance to them. The top three issues included "maintaining my ability to recommend the treatment option I feel is most appropriate for my patients," "receiving fair reimbursement for the dental services I provide," and "protecting myself, my staff and my patients from communicable diseases." New dentists found other items to be more significant to them compared with members overall. Although ADA members as a whole had similar views on critical issues facing dentistry and ADA priorities, there were significant differences regarding some issues. New dentists were far more concerned about securing funds for their practice and paying off debt than were all ADA members. Minority dentists expressed greater levels of concern about certain issues than did all ADA members. When planning and implementing ADA activities, the Association should continue to take into account members' relative rankings of professional issues and note issues of special interest to selected membership subgroups.

  20. Migration processes in SCO member states

    Directory of Open Access Journals (Sweden)

    Valentina Sergeevna Antonyuk

    2012-12-01

    Full Text Available The article concerns modern state and development of migration processes in SCO member states. As a main method of research statistical analysis was applied. The article shows that migration streams between SCO member states are rather intensive, and the problem of labor migration becomes more and more urgent. The countries of consuming and supplying of labour force are clearly differentiated in the region. For some countries, labor export is the key sector of economy. At the same time, interstate relations between SCO member states sometimes are rather disputed. The most urgent factors causing the development of migration processes in the region were determined. Among them, thefactor of growing outflows from China isespecially noted. It is noted that migration processes are discussed by SCO member states nowadays in terms of illegal migration and international criminality connected with it. It means that the question of labor migration is a real problem. It is indicated that the creation of a specific joint commission on migration policy affiliated with the Council of Foreign Ministers of SCO member states is the necessary condition of effective interaction in migration questions within the framework of Shanghai Cooperation Organization.

  1. Static Members of Classes in C#

    Directory of Open Access Journals (Sweden)

    Adrian LUPASC

    2017-12-01

    Full Text Available The C# language is object-oriented, which is why the declared member data must be part of a class. Thus, there is no possibility to declare certain variables that can be accessed from anywhere within the application, as it happens, for example, with global variables at the C language level. Making this work in C# is possible through static members of the class. Declaring a class implies defining some of its member data that later receive values when creating each object. A static member of the class can be interpreted as belonging only to the class, not to the objects subsequently created, which means that for the non-static data, there are as many children as there were objects created, while for the static ones there is only one copy, regardless of the number of created objects. In this regard, this paper presents the main aspects that characterize these abstract concepts of object oriented programming in general and C# language in particular, detailing how to develop an application that includes both static and non-static members. At the same time, particularities in the mirror for the two types of data, restrictions on use and potential limitations are presented.

  2. Does formal mentoring for faculty members matter? A survey of clinical faculty members.

    Science.gov (United States)

    Mylona, Elza; Brubaker, Linda; Williams, Valerie N; Novielli, Karen D; Lyness, Jeffrey M; Pollart, Susan M; Dandar, Valerie; Bunton, Sarah A

    2016-06-01

    Mentoring relationships, for all medical school faculty members, are an important component of lifelong development and education, yet an understanding of mentoring among medical school clinical faculty members is incomplete. This study examined associations between formal mentoring relationships and aspects of faculty members' engagement and satisfaction. It then explored the variability of these associations across subgroups of clinical faculty members to understand the status of mentoring and outcomes of mentoring relationships. The authors hypothesised that academic clinical faculty members currently in formal mentoring relationships experience enhanced employee engagement and satisfaction with their department and institution. Medical school faculty members at 26 self-selected USA institutions participated in the 2011-2014 Faculty Forward Engagement Survey. Responses from clinical faculty members were analysed for relationships between mentoring status and perceptions of engagement by faculty members. Of the 11 953 clinical faculty respondents, almost one-third reported having a formal mentoring relationship (30%; 3529). Most mentored faculty indicated the relationship was important (86%; n = 3027), and over three-fourths were satisfied with their mentoring experience (77%; n = 2722). Mentored faculty members across ranks reported significantly higher levels of satisfaction and more positive perceptions of their roles in the organisation. Faculty members who were not receiving mentoring reported significantly less satisfaction with their workplace environment and lower overall satisfaction. Mentored clinical faculty members have significantly greater satisfaction with their department and institution. This multi-institutional study provides evidence that fostering mentoring opportunities may facilitate faculty members' satisfaction and engagement, which, in turn, may help medical schools retain high-quality faculty staff committed to the multidimensional

  3. Cracking in Flexural Reinforced Concrete Members

    DEFF Research Database (Denmark)

    Rasmussen, Annette Beedholm; Fisker, Jakob; Hagsten, Lars German

    2017-01-01

    The system of cracks developing in reinforced concrete is in many aspects essential when modelling structures in both serviceability- and ultimate limit state. This paper discusses the behavior concerning crack development in flexural members observed from tests and associates it with two different...... existing models. From the investigations an approach is proposed on how to predict the crack pattern in flexural members involving two different crack systems; primary flexural cracks and local secondary cracks. The results of the approach is in overall good agreement with the observed tests and captures...... the pronounced size effect associated with flexural cracking in which the crack spacing and crack widths are approximately proportional to the depth of the member....

  4. Geneva University honours two CERN staff members

    CERN Multimedia

    2001-01-01

    Albert Hofmann Steve Myers On 8 June, two CERN staff members will receive Geneva University's highest distinction. On the proposal of the University's particle physicists, Steve Myers and Albert Hoffmann, who orchestrated LEP commissioning and operation and were instrumental in its success, will awarded the distinction of doctor honoris causa. The ceremony, interspersed with musical interludes, will be followed by a formal reception and is open to all. The Uni Dufour car park will be free to members of the public attending the ceremony. 8 June 2001 at 10.00 a.m. Uni Dufour, Auditoire Piaget 24, rue Général Dufour, Geneva.

  5. Power budget improvement of symmetric 40 Gb/s TWDM based PON2 system utilizing DMLs and DCF technique

    Science.gov (United States)

    Bindhaiq, Salem; Zulkifli, Nadiatulhuda; Supa'at, Abu Sahmah M.; Idrus, Sevia M.; Salleh, M. S.

    2018-01-01

    In this paper, we propose to use optical dispersion compensation based on the widely deployed compensating fiber (DCF) employing directly modulated lasers (DMLs) to improve the power budget in a symmetric 40 Gb/s time and wavelength division multiplexed-passive optical network (TWDM-PON) systems. The DML output waveforms in terms of output optical power, bandwidth enhancement factor (α) characteristics are investigated in order to minimize the effect of DML chirp and improve the transmission performance. Simulation results show dispersion compensation of up to 140 km of SMF with power budget of 56.6 dB and less than 2 dB dispersion penalty. The feasibility of bandwidth enhancement factor and power budget is also investigated. The simulation results indicate sufficient dispersion compensation for TWDM-PON based on DML transmission, which may vary considerably in their practical demonstration due to different system characterization.

  6. Efficient eNB inter-communication scheme in converged mobile and NG-PON2 system

    Science.gov (United States)

    Xiao, Simiao; Sun, Xiao; Zhang, Kaibin

    2016-02-01

    In LTE, a new X2-interface is defined to facilitate direct communication between neighboring eNBs. Since LTE is an all-IP network, the X2-interface traffic currently needs to be routed and transponded in L3 at the edge router by IP addressing. As mobile data increases, it is a promising trend to backhaul mobile services based on PON. In this paper, an effective approach for eNB inter-communication over TWDM-PON is proposed. By associating the IP address of eNB and the MAC address of ONU, the "inter-eNB communication in L3" can be mapped into "inter-ONU communication in L2" and transponded via the protocol of PON at the OLT. Thus, fast and cost-effective eNB inter-communication can be realized based on TWDM-PON within one wavelength channel and between different wavelength channels. The increasing data traffic pressure to the core network can also be alleviated.

  7. Migration from New EU Member Countries

    DEFF Research Database (Denmark)

    Pytlikova, Mariola

    2007-01-01

    The main purpose of the paper is to give predictions of the migration potential from the 7 new EU member countries to the EEA/EU-13 countries. Being able to analyze 'real' migration behavior from these particular countries over the period 1990-2000 helps me to avoid problems related to (double) o...

  8. Role Orientations of Members of Parliament

    NARCIS (Netherlands)

    Thomassen, Jacques J.A.; Esaiasson, Peter

    2006-01-01

    To what extent would a change of the Dutch electoral system, strengthening the bond between individual Members of Parliament (MPs) and specific constituencies, improve the quality of political representation, and increase the legitimacy of the political system in the process? In order to answer this

  9. Members' needs, intragroup conflict, and group performance.

    Science.gov (United States)

    Chun, Jinseok S; Choi, Jin Nam

    2014-05-01

    Focusing on "what people want in their group" as a critical antecedent of intragroup conflict, the present study theorizes and empirically investigates the relationships among the psychological needs of group members, intragroup conflict, and group performance. It attends to the within-group average and dispersion of members' psychological needs and examines the effects stemming from group composition of needs on multiple types of conflict. The analyses based on multisource data from 145 organizational teams revealed significant relationships between the groups' composition with respect to the members' need for achievement and task conflict, need for affiliation and relationship conflict, and need for power and status conflict. Some of these relationships were moderated by open communication among members. The analyses also demonstrated that when the 3 types of conflict were considered together, task conflict was a positive predictor of group performance, whereas relationship conflict was a negative predictor. The findings highlight the motivational aspects of intragroup conflict, revealing the multilevel dynamics of the psychological needs in social settings. (c) 2014 APA, all rights reserved.

  10. Boron--epoxy tubular structure members

    Science.gov (United States)

    Shakespeare, W. B. J.; Nelson, P. T.; Lindkvist, E. C.

    1973-01-01

    Composite materials fabricate thin-walled tubular members which have same load-carrying capabilities as aluminum, titanium, or other metals, but are lighter. Interface between stepped end fitting and tube lends itself to attachments by primary as well as secondary bonding. Interlaminar shear and hoop stress buildup in attachment at end fitting is avoided.

  11. Phylogenetic relationships among members of the Pachydactylus ...

    African Journals Online (AJOL)

    The Pachydactylus capensis group is a phenetically-defined assemblage of five small-bodied geckos broadly distributed in eastern southern Africa. Several additional small-bodied Pachydactylus have been historically considered subspecies of P. capensis or members of this group. To assess evolutionary relationships ...

  12. WTO Members' Commitments in Education Services

    Science.gov (United States)

    Xu, Jian

    2009-01-01

    The establishment of World Trade Organization is in line with the conclusion reached at the end of the Uruguay Round in April 1994 by the bulk of the world's trading nations. WTO is in charge of managing multilateral trading system. WTO's "General Agreement on Trade in Services" (GATS) requires member nations to comply with the following…

  13. Issues Causing Stress among Business Faculty Members

    Science.gov (United States)

    Adrian, C. Mitchell; Cox, Susie S.; Phelps, Lonnie D.; Schuldt, Barbara A.; Totten, Jeff W.

    2014-01-01

    This study examines factors contributing to faculty stress. Factors including demographics, tenure, discipline, and teaching medium are all examined. Whereas once faculty members were inundated with learning new electronic technology (and the stress it created), many appear to have become somewhat comfortable with this change and have adapted to…

  14. Important characteristics of operational force members

    CSIR Research Space (South Africa)

    Van Heerden, Adelai

    2017-10-01

    Full Text Available The operational forces military context is generally acknowledged as one of the most stressful contexts as it is demanding of members on a physical, psychological, social level with organisational, intra- and inter-personal demands of an extreme...

  15. Israel, CERN’s new Member State

    CERN Multimedia

    Anaïs Schaeffer

    2014-01-01

    On Wednesday, 15 January 2014, the official Israeli Flag-raising Ceremony took place to mark the accession of Israel to Membership of CERN, bringing the Organization’s number of Member States to 21.     For more information, click here.

  16. 7 CFR 983.42 - Initial members and nomination of successor members.

    Science.gov (United States)

    2010-01-01

    ...) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF... alternate is selected shall serve in place of that member on the committee, and shall have and be able to... members of the committee shall serve for terms of two years: Provided, That four of the initially selected...

  17. Why 4-H Members Leave: A Study of Discontinuance through Both Current 4-H Members and Former Members

    Science.gov (United States)

    Chilek, Kevin Dwayne

    2012-01-01

    4-H members quit. It is part of every 4-H program, and according to the research, it is even part of growing up. If only we knew why they quit, we could possibly do something about it. To date, the reasons youth join 4-H have been more thoroughly researched than the reasons they quit. This study explores why youth choose to discontinue membership…

  18. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrive Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996. Photo 01: CERN Director-General Prof. Luciano Maiani (left) speaks to Forum members and public figures from the Geneva area during the visit. In the background is Jean-Claude Landry from the Department of the Interior, Agriculture and Environment, State of Geneva. Photo 02: CERN Director-General Prof. Luciano Maiani (left) speaks to Forum members and public figures from the Geneva area during the visit. In the background is Bernard Ecoffey, Founder of the Forum Engelberg.

  19. Surface modifying method for metal member

    International Nuclear Information System (INIS)

    Amano, Kazuo; Enomoto, Kunio; Hirano, Akihiko; Hirano, Atsuya; Hattori, Shigeo; Hayashi, Eisaku; Ueyama, Toshiharu; Hayashi, Makoto

    1998-01-01

    A surface of a metal member such as carbon steel to be used in a corrosion circumstance such as in a nuclear power plant and a thermoelectric plant are polished. A printing method is conducted for removing obstacles on the surface of the member. Namely, a photographing printing paper immersed in a diluted sulfuric acid solution is appended tightly to the portion with its surface polished smoothly. Sulfur present in the form of an obstacle of MnS or present alone in the material reacts with the sulfuric acid to form a sulfuric acid gas, and reacts with Ag of the printing paper to discolor the printing paper to brown. When a peeled printing paper is discolored to brown, sulfur printing is repeated. After conforming that the peeled printing paper is white, the surface is washed. Subsequently, surface plasticization is conducted by water jet peening or shot peening. (I.N.)

  20. Identifying New Members of Nearby Moving Groups

    Science.gov (United States)

    Holmbeck, Erika; Vican, Laura

    2014-06-01

    Our group has assembled a sample of 14,000 stars of spectral types B9-M9 with measured UVW Galactic space velocities and lying within 125 pc of Earth. We have identified candidate members of three nearby young (less than 100 Myr) moving groups. For stars of spectral types G5 and later, we have used the Kast spectrometer on the Shane 3m telescope at Lick Observatory to measure lithium abundance in order to determine stellar ages. With the data we have obtained from this run, we will be able to establish whether our candidates are bona fide members of the moving groups in question. I will be presenting the preliminary results from this survey, including spectra of the ~50 stars observed thus far. These nearby young stars will make excellent targets for direct imaging followup surveys, since any giant planets around young stars will still be warm, and will therefore be bright enough to detect with instruments like GPI.

  1. Lithuania to become Associate Member of CERN

    CERN Multimedia

    Dačkus, Robertas

    2017-01-01

    On 27 June 2017, in Vilnius, Lithuania, CERN Director General, Fabiola Gianotti, and the Minister of Foreign Affairs of the Republic of Lithuania, Linas Linkevičius, in the presence of the President of the Republic of Lithuania, Dalia Grybauskaitė, signed the Agreement admitting Lithuania as an Associate Member of CERN. The last step for the Agreement to enter into force requires final approval by the Government of Lithuania.

  2. Mapping organizational members' sense of fit

    OpenAIRE

    Billsberry, Jon; Marsh, Philip; Moss-Jones, John

    2004-01-01

    Despite its importance in the organizational behavior literature, person–organization (P–O) fit remains an elusive construct. One reason for this is the lack of research about organizational members’ own sense of their P–O fit. In this paper we report an empirical study that explored organizational members’ own sense of fit using storytelling and causal mapping techniques. The results suggest that organizational members categorize their perceptions of their fit into five discrete domains (job...

  3. Service Member Suicide and Readiness: An Analysis

    Science.gov (United States)

    2017-05-25

    command, and degrades the morale of those still serving, as well as the American public.8 A shrinking number of qualified volunteers and reductions...to Sri Aurobindo’s Philosophy of Integral Non-Dualism,” in The Integral Philosophy of Sri Aurobindo, ed. Haridas Chaudhuri and Frederic Spiegelberg...potentially unsolvable problem should not prevent attempts to develop solutions. In a moral sense, service member suicide should elicit greater diligence

  4. Member State Event: Telling CERN's story !

    CERN Multimedia

    2004-01-01

    As part of the events to mark the Laboratory's fiftieth anniversary, members of the CERN personnel are telling the story of CERN. Robert Cailliau (on the right), currently responsible for CERN's external communications, and Chiara Mariotti (in the center), a physicist working at CMS, were invited to talk about the history of CERN and the Web at a conference in the 'Science Thursdays' series entitled 'From the Quark to the Web' in Turin on 26 February.

  5. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996. He is pictured here (right) alongside CERN Director-General Prof. Luciano Maiani during the visit of Forum members to CERN.

  6. REGISTRATION OF VEHICLES IN SWITZERLAND: MEMBERS OF THE FAMILY OF A MEMBER OF THE PERSONNEL

    CERN Multimedia

    Service des Relations avec les Pays Hôtes

    1999-01-01

    The Permanent Mission of Switzerland to the International Organisations in Geneva has informed CERN that members of the family of a member of the personnel who hold a carte delégitimation or a Ci permit may not register a vehicle in Switzerland. Only those members of the family who are of Swiss nationality or hold an ordinary permit (e.g. a 'B' or 'C' permit) may register vehicles in their own names.Relations with the Host States Servicehttp://www.cern.ch/relations/Tel. 72848

  7. Member State Event: Telling CERN's Story

    CERN Multimedia

    2004-01-01

    As part of the events to mark the Laboratory's fiftieth anniversary, members of the CERN personnel are telling the story of CERN. Robert Cailliau (on the right of the photograph), co-inventor of the Web and currently responsible for CERN's external communications, and Chiara Mariotti (in the center), a physicist working at CMS, were invited to talk about the history of CERN and the Web at a conference in the 'Science Thursdays' series entitled 'From the Quark to the Web' in Turin on 26 February. This was not their first appearance before a non-specialist audience (almost 1000 people that day!) eager to find out what goes on in a unique research centre like CERN as talking about the Laboratory's activities and its history are part and parcel of their work for the Organization. Anniversary Events in the Member States: This 'Science Thursday' event devoted to CERN was one of Italy's contributions to CERN's fiftieth anniversary celebrations. Coming up soon in the Member States: Italy International Centre...

  8. A Non-Member Spouse's Entitlement To The Member's Pension Interest

    Directory of Open Access Journals (Sweden)

    Motseotsile Clement Marumoagae

    2014-12-01

    Full Text Available It is important that married couples seek legal advice with regard to the assets falling within their joint estate, more particularly their retirement benefits. This article reflects on the entitlement (if any of non-member spouses to their spouses' retirement fund benefits. Pension benefits can be due before, during or after divorce, and parties to the marriage should be aware of their rights with regard to the accruing pension benefits of their spouses. While it is settled law that non-member spouses are entitled to receive a portion of their member spouses' pension benefits (known as "pension interest" immediately on divorce, it is not particularly clear whether non-member spouses are also entitled to receive the same before or sometime after divorce. In this article I provide a contextual understanding of the entitlements (if any which spouses or former spouses of members of pension funds have on such member spouses' retirement benefits. Furthermore, it shown in this article that various divisions of South African High Courts have been inconsistent in how they have approached the issue of the pension interest between divorcing spouses or divorced ex-spouses.

  9. Post-fire assessment of structural wood members

    Science.gov (United States)

    Robert J. Ross; Brian K. Brashaw; Xiping Wang; Robert H. White; Roy F. Pellerin

    2005-01-01

    Since the interior of a charred wood member normally retains its structural integrity, large structural wood members often do not need to be replaced after a fire. Engineering judgement is required to determine which members can remain and which members need to be replaced or repaired. Due to the lack of established methods to directly determine the residual capacity...

  10. Suicidal behavior among members of Gamblers Anonymous.

    Science.gov (United States)

    Frank, M L; Lester, D; Wexler, A

    1991-09-01

    A national sample of 500 members of Gamblers Anonymous was surveyed by mail in order to gather information on suicidal history. One hundred sixty two usable surveys were returned representing 32.4% of the original sample. Compulsive gamblers who had a history of suicidal preoccupation began gambling at an earlier age than nonsuicidal gamblers and were more likely to have stolen to support their gambling. They also tended to have addicted relatives and children more than nonsuicidal gamblers did. The data suggest that those gamblers who had been suicidal tend to be more serious gamblers than nonsuicidal respondents.

  11. Looking Backward, Looking Forward: MLA Members Speak

    OpenAIRE

    Alliston, April; Ammons, Elizabeth; Arnold, Jean; Baym, Nina; Beckett, Sandra L; Beidler, Peter G; Berger, Roger A; Bermann, Sandra; Wilson, J. J; Boone, Troy; Booth, Alison; Booth, Wayne C; Phelan, James; Borroff, Marie; Hassan, Ihab

    2000-01-01

    In 1997 I was asked to organize humanities outreach activities at the University of California, Irvine. The result was the formation of Humanities Out There (HOT). In our workshops, faculty members and graduate students supervise teams of undergraduates in order to take the methods and materials of the university into the larger community. I believe that programs like these will  become increasingly important in the next century, as economic, cultural, and educational divisions deepe...

  12. Members of the State Council of Geneva

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    Luncheon hosted by the Director-General for members of the State Council of Geneva: From left to right A. Naudi; J. May; M. Carlo Lamprecht, State Council - Employement, Foreign Office and Economic Departement; M. Robert Hensler, State Chancellor; L. Maiani, CERN Director General; H.F. Hoffmann; M. Robert Cramer, State Council - Environment, Agriculture and Interior Departement; J.Van Der Boon; M. Laurent Moutinot, State Council - Installation, equipment and housing Departement; C. Détraz; C. Wyss; P. Jenni; G. Hentsch; M. Pierre-François Unger, State Council - Health and Social Action Departement; G. Stassinakis; M. Bourquin, CERN Council President.

  13. Cooperation with COMECON members in coke chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Medricky. Z

    1987-05-01

    Discusses activities of the coking industry division of the standing committee for iron metallurgy of the COMECON. The following cooperation fields are analyzed: raw material basis for coking industry, coal charge preparation and methods for reducing proportion of coking coal in a coal charge (heat treatments, formed coke processes, partial briquetting, pelletizing, increasing coking temperature, packing etc.), coking technology, coke quenching, screening, chemical processing of coal gas, environmental protection in the coking industry, environmental effects of coking, pitch coke production, methods for increasing labor productivity. Research programs coordinated by member countries are reviewed. Programs in which Czechoslovakia participates are discussed.

  14. BVA members wow judges in photo competition.

    Science.gov (United States)

    2016-09-03

    Earlier this year, BVA ran its inaugural photo competition, giving members the opportunity to showcase the work of the veterinary profession and the animals and wildlife they encounter. Standing out from over 400 high-quality entries, judges picked the images reproduced in this month's BVA News as the winning and highly commended photos. To see all the entries and hear from the winners, visit www.bva.co.uk/vet-photos-2016/. There will be another photo competition in 2017 with more categories to be announced. British Veterinary Association.

  15. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Photo 01: Members of the Forum Engelberg and public figures from Geneva visit SM18, the test hall for LHC magnets: (left to right) N. Siegel, Prof. Dr. Med. Bernard Mach, Mr Alexander Höchli, H. Wenninger, Mrs Mireille Quirina, Mme Konrade Von Bremen, Mrs Thérèse Wolf, Prof. Roger Berthouzoz, Mrs Marie-Anne Heimo, Mr Bernard Ecoffey.

  16. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996. Horst Wenninger (left) in animated discussion with Alexander Höchli, member of the Institutional Committee of Forum Engelberg and former Landammann of the canton of Obwalden.

  17. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996. Photo 01: Thérèse Wolf, Secretary of Forum Engelberg; Alain Hervé; Horst Wenninger; and Alexander Höchli, Forum member and former Landammann of the canton of Obwalden, at the CMS detector's assembly site.

  18. Czech Republic joins IPPOG as member

    CERN Multimedia

    'marcelloni, claudia

    2018-01-01

    Czech Republic became an official IPPOG member on April 21 2018. The MOU between Czech Republic and IPPOG was previously signed by the director of the Institute of Physics of the Academy of Sciences of the Czech Republic. IPPOG chairs confirmed the agreement by signing the MOU during the meeting in Pisa in presence of IPPOG representative for Czech Republic dr. Vojtech Pleskot from the Faculty of Mathematics and Physics, Charles University in Prague. Dr. Vojtech Pleskot replaces Dr. Jiri Rames who did an excellent job during his long term work in the EPPOG and IPPOG.

  19. Reactor vessel supported by flexure member

    International Nuclear Information System (INIS)

    Crawford, J.D.; Pankow, B.

    1977-01-01

    According to the present invention there is provided an improved arrangement for supporting a reactor vessel within a containment structure against static and dynamic vertical loadings capable of being imposed as a result of a serious accident as well as during periods of normal plant operation. The support arrangement of the invention is, at the same time, capable of accommodating radial displacements that normally occur between the reactor vessel and the containment structure due to operational transients. The arrangement comprises a plurality of vertical columns connected between the reactor vessel and a support base within the containment structure. The columns are designed to accommodate relative displacements between the vessel and the containment structure by flexing. This eliminates the need for relative sliding movements and thus enables the columns to be securely fixed to the vessel. This elimination of a provision for relative sliding movements avoids the spaces or gaps between the retention members and the retained elements as occurred in prior art arrangements and, concomitantly, the danger of establishing impact forces on the retention members in the event of an accident is reduced. (author)

  20. The dying child and surviving family members.

    Science.gov (United States)

    Shrier, D K

    1980-12-01

    This overview of death and dying focuses on the dying child and surviving family members. Children's concepts of death at different developmental stages are reviewed. These range from an inability to distinguish death from other forms of separation prior to age 3, through partial concepts of death until, by age 10 to 15 years, children are able to conceptualize death as universal, inevitable and final. The importance of adults assisting in the child's growing comprehension of death is stressed. The stages of grief and mourning, as outlined by Kubler-Ross, are reviewed from the perspective of the child and family: denial, anger, bargaining, depression and acceptance. Recognition is given to the variations in coping styles among different family members. The special circumstances related to the death of an infant and the impact of the death of a child on the surviving siblings are discussed. Specific helpful interventions to assist families in coping with mourning are described. The death of a child remains one of the most painful and difficult events for a family and its physician to accept.

  1. To all members of the personnel

    CERN Multimedia

    2005-01-01

    Temporary work for children of members of the personnel During the period mid-June to mid-September 2005, a limited number of vacancies for temporary work at CERN (normally unskilled work of a routine nature) will be available to children of members of the personnel (i.e. anyone holding an employment or association contract with CERN). It should be noted that candidates must be aged between 18 and 24 inclusive on the first day of the contract, and that they must have insurance cover for both illness and accident. In view of the limited number of vacancies available, no children having previously worked at CERN under this scheme can be considered. The duration of all appointments will be 4 weeks and the allowance for the period will be CHF 1621.- net. Candidates should apply via the HR Department's electronic recruitment system (E-rt) : http://humanresources.web.cern.ch/humanresources/internal/personnel/pmd/cr/Staff-kids-05.pdf Completed application forms must be returned to this Service by 8 April 2005 ...

  2. To all members of the personnel

    CERN Multimedia

    HR Department

    2011-01-01

    Summer work for children of members of the personnel During the period from 13 June to 16 September 2011 inclusive, there will be a limited number of jobs for summer work at CERN (normally unskilled work of a routine nature), which will be made available to children of members of the personnel (i.e. anyone holding an employment or association contract with the Organization). Candidates must be aged between 18 and 24 inclusive on the first day of the contract, and must have insurance coverage for both illness and accident. The duration of all contracts will be 4 weeks and the allowance will be 1717 CHF for this period. Candidates should apply via the HR Department’s electronic recruitment system (E-rt): https://ert.cern.ch/browse_intranet/wd_pds?p_web_site_id=1&p_web_page_id=8886&p_no_apply=&p_show=N Completed application forms must be returned by 11 April 2011 at the latest. The results of the selection will be available by the end of May 2011. For further information, please con...

  3. TO ALL MEMBERS OF THE PERSONNEL

    CERN Multimedia

    2003-01-01

    Temporary work for children of members of the personnel During the period mid-June to mid-September 2003, there will be a limited number of vacancies for temporary work at CERN (normally unskilled work of routine nature) which will be made available to children of members of the personnel (i.e. anyone holding an employment or association contract with CERN). It should be noted that candidates must be aged between 18 and 24 inclusive on the first day of the contract, and that they must have insurance cover for both illness and accident. In view of the limited number of vacancies available, no children previously appointed at CERN under this scheme can be considered. The duration of all appointments will be 4 weeks, the allowance being CHF 1582.- for this period. Application form can be obtained from Martine PLAZA, HR Division (by using the slip in the bulletin or by electronic mail to Martine.Plaza@cern.ch) or at http://cern.ch/hr-web/internal/general/HN-personnel/ Completed application forms must be returne...

  4. TO ALL MEMBERS OF THE PERSONNEL

    CERN Multimedia

    2003-01-01

    Temporary work for children of members of the personnel During the period mid-June to mid-September 2003, there will be a limited number of vacancies for temporary work at CERN (normally unskilled work of routine nature) which will be made available to children of members of the personnel (i.e. anyone holding an employment or association contract with CERN). It should be noted that candidates must be aged between 18 and 24 inclusive on the first day of the contract, and that they must have insurance cover for both illness and accident. In view of the limited number of vacancies available, no children previously appointed at CERN under this scheme can be considered. The duration of all appointments will be 4 weeks, the allowance being CHF 1582.- for this period. Application form can be obtained from Martine PLAZA, HR Division (by electronic mail to Martine.Plaza@cern.ch) or at http://cern.ch/hr-web/internal/general/HN-personnel/ Completed application forms must be returned to this service by 2 May 2003 at th...

  5. TO ALL MEMBERS OF THE PERSONNEL

    CERN Multimedia

    2003-01-01

    Temporary work for children of members of the personnel During the period mid-June to mid-September 2003, there will be a limited number of vacancies for temporary work at CERN (normally unskilled work of routine nature) which will be made available to children of members of the personnel (i.e. anyone holding an employment or association contract with CERN). It should be noted that candidates must be aged between 18 and 24 inclusive on the first day of the contract, and that they must have insurance cover for both illness and accident. In view of the limited number of vacancies available, no children previously appointed at CERN under this scheme can be considered. The duration of all appointments will be 4 weeks, the allowance being CHF 1582.- for this period. Application form can be obtained from Martine PLAZA, HR Division (by electronic mail to Martine.Plaza@cern.ch) or at http://cern.ch/hr-web/internal/general/HN-personnel/ Completed application forms must be returned to this service by 2 May 2003 at t...

  6. To all members of the personnel

    CERN Multimedia

    HR Department

    2009-01-01

    Temporary work for children of members of the personnel During the period from 15 June to 11 September 2009 inclusive, there will be a limited number of jobs for temporary work at CERN (normally unskilled work of routine nature), which will be made available to children of members of the personnel (i.e. anyone holding an employment or association contract with the Organization). Candidates must be aged between 18 and 24 inclusive on the first day of the contract, and must have insurance coverage for both illness and accident. The duration of all appointments will be 4 weeks and the allowance will be CHF 1717. - for this period. Candidates should apply via HR Department’s electronic recruitment system (E-rt): https://ert.cern.ch/browse_www/wd_pds?p_web_page_id=6970 Completed application forms must be returned by 10 April 2009 at the latest. The results of the selection will be available on 22 May 2009. For further information, please contact: mailto:Inger.Carriero@cern.c...

  7. To all members of the personnel

    CERN Multimedia

    HR Department

    2009-01-01

    Temporary work for children of members of the personnel During the period from 15 June to 11 September 2009 inclusive, there will be a limited number of jobs for temporary work at CERN (normally unskilled work of a routine nature), which will be made available to children of members of the personnel (i.e. anyone holding an employment or association contract with the Organization). Candidates must be aged between 18 and 24 inclusive on the first day of the contract, and must have insurance coverage for both illness and accident. The duration of all appointments will be 4 weeks and the allowance will be CHF 1717. - for this period. Candidates should apply via the HR Department’s electronic recruitment system (E-rt): https://ert.cern.ch/browse_www/wd_pds?p_web_page_id=6970 Completed application forms must be returned by 10 April 2009 at the latest. The results of the selection will be available on 22 May 2009. For further information, please contact: mailto:Inger.Carriero@...

  8. To all members of the personnel

    CERN Multimedia

    HR Department

    2008-01-01

    Temporary work for children of members of the personnel During the period from 16 June to 12 September 2008 inclusive, there will be a limited number of jobs for temporary work at CERN (normally unskilled work of a routine nature), which will be open to children of members of the personnel (i.e. anyone holding an employment or association contract with the Organization). Candidates must be aged between 18 and 24 inclusive on the first day of the contract, and must have insurance coverage for both illness and accident. The duration of appointments will be 4 weeks and the allowance for this period will be 1663.- CHF. Candidates should apply via the HR Department’s electronic recruitment system (E-rt): https://ert.cern.ch/browse_www/wd_pds?p_web_page_id=6160 Completed application forms must be made on-line by 13 April 2008 at the latest. The results of the selection will be available on 18 May 2008. For further information, please contact: Geraldine.Ballet@cern.ch HR ...

  9. To all members of the personnel

    CERN Multimedia

    2006-01-01

    Temporary work for children of members of the personnelDuring the period 12 June to 15 September 2006 included, there will be a limited number of jobs for temporary work at CERN (normally unskilled work of routine nature) which will be made available to children of members of the personnel (i.e. anyone holding an employment or association contract with CERN). It should be noted that candidates must be aged between 18 and 24 inclusive on the first day of the contract, and that they must have insurance cover for both illness and accident. In view of the limited number of jobs available, no children who have previously worked at CERN under this scheme can be considered. The duration of all appointments will be 4 weeks, the allowance being CHF 1640.- for this period. Candidates should apply via HR department's electronic recruitment system (E-rt): https://ert.cern.ch/browse_www/wd_pds?p_web_page_id=4691 Completed application forms must be returned to this service by 17 April 2006 at the latest. The results of t...

  10. To all members of the personnel

    CERN Multimedia

    HR Department

    2008-01-01

    Temporary work for children of members of the personnel During the period from 16 June to 12 September 2008 inclusive, there will be a limited number of jobs for temporary work at CERN (normally unskilled work of a routine nature), which will be open to children of members of the personnel (i.e. anyone holding an employment or association contract with the Organization). Candidates must be aged between 18 and 24 inclusive on the first day of the contract, and must have insurance coverage for both illness and accident. The duration of appointments will be 4 weeks and the allowance for this period will be 1663 CHF. Candidates should apply via the HR Department’s electronic recruitment system (E-rt): https://ert.cern.ch/browse_www/wd_pds?p_web_page_id=6160 Completed application forms must be submitted on-line by 13 April 2008 at the latest. The results of the selection will be available on 18 May 2008. For further information, please contact: mailto:Geraldine.Ballet@cern....

  11. To all members of the personnel

    CERN Multimedia

    HR Department

    2010-01-01

    Summer work for children of members of the personnel During the period from 14 June to 17 September 2010 inclusive, a limited number of jobs for summer work at CERN (normally unskilled work of a routine nature) will be made available to children of members of the personnel (i.e. anyone holding an employment or association contract with the Organization). Candidates must be aged between 18 and 24 inclusive on the first day of the contract, and must have insurance coverage for both illness and accident. The duration of all contracts will be 4 weeks and the allowance will be 1717 CHF for this period. Candidates should apply via the HR Department’s electronic recruitment system (E-rt): https://ert.cern.ch/browse_www/wd_pds?p_web_page_id=7716 Completed application forms must be returned by 9 April 2010 at the latest. The results of the selection will be available on 21 May 2010. For further information, please contact: Inger.Carriero@cern.ch Tel. 71372

  12. To all members of the personnel

    CERN Multimedia

    Martine Briant

    2006-01-01

    Temporary work for children of members of the personnelDuring the period 12 June to 15 September 2006 included, there will be a limited number of jobs for temporary work at CERN (normally unskilled work of routine nature) which will be made available to children of members of the personnel (i.e. anyone holding an employment or association contract with CERN). It should be noted that candidates must be aged between 18 and 24 inclusive on the first day of the contract, and that they must have insurance cover for both illness and accident. In view of the limited number of jobs available, no children who have previously worked at CERN under this scheme can be considered. The duration of all appointments will be 4 weeks, the allowance being CHF 1640.- for this period. Candidates should apply via HR department's electronic recruitment system (E-rt) : https://ert.cern.ch/browse_www/wd_pds?p_web_page_id=4691 Completed application forms must be returned to this service by 17 April 2006 at the latest. The results of ...

  13. To all members of the personnel

    CERN Multimedia

    FI Department

    2008-01-01

    Temporary work for children of members of the personnel During the period from 16 June to 12 September 2008 inclusive, there will be a limited number of jobs for temporary work at CERN (normally unskilled work of routine nature), which will be made available to children of members of the personnel (i.e. anyone holding an employment or association contract with the Organization). Candidates must be aged between 18 and 24 inclusive on the first day of the contract, and must have insurance coverage for both illness and accident. The duration of appointments will be 4 weeks and the allowance for this period will be 1663.- CHF. Candidates should apply via HR Department’s electronic recruitment system (E-rt): https://ert.cern.ch/browse_www/wd_pds?p_web_page_id=6160 Completed application forms must be made on-line by 13 April 2008 at the latest. The results of the selection will be available on 18 May 2008. For further information, please contact: mailto:Geraldine.Ballet@cer...

  14. To all members of the personnel

    CERN Multimedia

    HR Department

    2009-01-01

    Temporary work for children of members of the personnel During the period from 15 June to 11 September 2009 inclusive, there will be a limited number of jobs for temporary work at CERN (normally unskilled work of a routine nature), which will be made available to children of members of the personnel (i.e. anyone holding an employment or association contract with the Organization). Candidates must be aged between 18 and 24 inclusive on the first day of the contract, and must have insurance coverage for both illness and accident. The duration of all appointments will be 4 weeks and the allowance will be CHF 1717. - for this period. Candidates should apply via the HR Department’s electronic recruitment system (E-rt): https://ert.cern.ch/browse_www/wd_pds?p_web_page_id=6970 Completed application forms must be returned by 10 April 2009 at the latest. The results of the selection will be available on 22 May 2009. For further information, please contact: mailto:Inger.Carriero...

  15. Transfer pricing rules in EU member states

    Directory of Open Access Journals (Sweden)

    Veronika Solilová

    2010-01-01

    Full Text Available One of the important area of international taxes is transfer pricing. Transfer price is a price set by a taxpayer when selling to, buying from, or sharing resources with a related (associated person. The tran­sac­tions between these persons should be assessed at their arm’s length price in according the arm’s length principle – international accepted standard – as the price which would have been agreed between unrelated parties in free market conditions. This paper is focused on the tranfer pricing rules used in particular EU Member States so as if EU Member States apply the arm’s length principle, define the related persons, apply recommendations of the OECD Guidelines, use the transfer pricing methods, require TP Documentation, exercise specific transfer pricing audit or impose specific penalties and apply APAs. Transfer pricing rules should prevent taxpayers from shifting income to related person organized in tax havens or in countries where they enjoy some special tax benefit.

  16. Preparative Production of Acetylcholinesterase and Paraoxonase in Procaryotic and Eucaryotic Expression Systems

    National Research Council Canada - National Science Library

    Sussman, Joel; Silman, I

    2004-01-01

    ... (HDL, good cholesterol% and are involved in the prevention of atherosclerosis. We describe the first crystal structure of a PON family member, a variant of PON1 obtained by directed evolution, at a resolution of 2.2...

  17. Grief elaboration in families with handicapped member.

    Science.gov (United States)

    Calandra, C; Finocchiaro, G; Raciti, L; Alberti, A

    1992-01-01

    Families with handicapped member seem to follow the same five stages (rejection and isolation, anger, dealing with the problem, depression, acceptance) of Kubler-Ross grief elaboration theory while dealing with the narcissistic wound of a handicapped child. Some of these families show a block in one of the stages. The effort of psychotherapy is to remove the block and let them reach the last stage. In this paper families under systemic psychotherapeutic treatment are analyzed, who had in common the birth of a child with low or modest invalidating signs and psychotic or autistic features. The families structure did not show the characteristics of a psychotic family. Nevertheless either one or both parents ignored the evidence of their child disease and they built a "disease-incongrous" wait around the child, trying to push away the painful reality. The authors explain the importance of this approach for the improvement of the autistic traits.

  18. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996.Seated here at a presentation by Peter Jenni, spokesperson for the ATLAS collaboration, during the visit of Forum members and Geneva public figures are Bernard Ecoffey, Founder of the Forum Engelberg (left), and Jean-Claude Landry, Department of the Interior, Agriculture and Environment, state of Geneva. Photo 01: (left to right) Bernard Ecoffey, Jean-Claude Landry and Peter Jenni. Photos 02, 03: (left to right) Jean-Claude Landry, Bernard Ecoffey and Peter Jenni.

  19. Migration from the new EU member countries

    DEFF Research Database (Denmark)

    Pedersen, Louise Møller; Lund Thomsen, Trine

    2012-01-01

    investigates the potentials, limitations and conflicts of interests that are connected with temporary employment of Eastern European migrant workers within the unskilled labour sectors seen from the perspective of Danish labour market actors; politicians, labour marked unions, Danish employers, Danish......During the past four years more than 52.500 Eastern European EU citizens have worked and lived in Denmark. Migrant workers from the new EU countries are characterized by a high degree of mobility, flexibility and eagerness in terms of working and adapting to working conditions. Poorer socioeconomic...... and working conditions in their home countries as well as being of another cultural background than their Danish colleagues brings with it many challenges. This article examines the consequences of low-skilled labour migration to Denmark from the new EU member countries in Eastern Europe. The article...

  20. Table of members of quasi-bands

    International Nuclear Information System (INIS)

    Sakai, Mitsuo.

    1984-04-01

    The probable members of the quasi-bands in even-even nuclei for Z between 6 and 100 are listed in this table. The terms quasi-bands have been introduced in the so-called spherical regions as the counter parts of the collective bands in the deformed regions. In the present compilation, the data for deformed nuclei are classified for convenience under the same titles, Quasi-Ground Band, Quasi-Beta Band and Quasi-Gamma Band, as are used for other nuclear regions. The present edition covers the literature through September, 1983. Fifteen newly discovered nuclides are included. The classification of energy level into quasi-bands is made on the basis of the systematic trend in the data over large groups of nuclei. (Kato, T.)

  1. Czech Republic to Become Member of ESO

    Science.gov (United States)

    2006-12-01

    Today, an agreement was signed in Prague between ESO and the Czech Republic, aiming to make the latter become a full member of ESO as of 1 January 2007. "The future membership of the Czech Republic in ESO opens for the Czech astronomers completely new opportunities and possibilities. It will foster this discipline on the highest quality level and open new opportunities for Czech industry to actively cooperate in research and development of high-tech instruments for astronomical research," said Miroslava Kopicová, Minister of Education, Youth and Sports of the Czech Republic. ESO PR Photo 52/06 ESO PR Photo 52/06 Signing Ceremony "We warmly welcome the Czech Republic as the thirteenth member of ESO," said Catherine Cesarsky, ESO's Director General. "The timing couldn't be better chosen: with the Very Large Telescope, Europe is now at the forefront of ground-based astronomy, and with the construction of ALMA and the final studies for the European Extremely Large Telescope, we will ensure that this will remain so for several decades. We look forward to working together with our Czech colleagues towards these successes." The signing event took place at the Czech Ministry of Education, Youth and Sports in Prague. Following ratification by the Czech Parliament, the Czech Republic with thus join the twelve present member states of ESO, the European Organisation for Astronomical Research in the Southern Hemisphere: Belgium, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. The Czech Republic is the first country from Central and Eastern Europe to join ESO. Astronomy in the Czech Republic has a very long tradition that dates from as far back as 3500 BC. Four centuries ago, Tycho Brahe and Johannes Kepler established themselves in Prague at the invitation of the emperor Rudolph II, laying the ground for the first golden age in astronomy. Later, eminent scientists such as Christian Doppler, Ernst Mach and

  2. Sensory loss amongst old family members

    DEFF Research Database (Denmark)

    Rasmussen, Jon Dag; Winther, Ida Wentzel

    2018-01-01

    and their close family. Our tentative findings point towards a prominence of different insecurities and discomforts in social life that directly links to the decreased sensory abilities. Experiences of being ‘lost’, ‘set afloat’ and disconnected in everyday life interactions are broadly described by all...... on the old people suffering a decline in sensory abilities, but also on family members as individual loss becomes collective loss in the context of family and kinship. The paper presentation takes its point of departure in rough pieces of empirical material (e.g. film-clips, sound......-clips/montage and ethnographic description) and through exposition of tentative analysis and research findings we aim to initiate a discussion around central themes of the work....

  3. (ReTranslating as Re-membering

    Directory of Open Access Journals (Sweden)

    Julie Tarif

    2016-07-01

    Full Text Available This paper explores how (retranslation – interlingual and intersemiotic – can be perceived as a way of both remembering the literary legacy of other cultures but also as a way of re-membering/re-generating the body of literature(s of the importing culture. It focuses on what is called “a classic” and anchors its reflexion in polysystem theory and in the metaphorical vision of literary works as an organic living body. To do so, it concentrates on the British literary classic Oliver Twist and its translations and adaptations into French. The article addresses the following questions: What is to be remembered of certain works? Why, how and by whom are those works remembered?

  4. OSART Works to Help Member States

    International Nuclear Information System (INIS)

    Kaiser, Peter

    2013-01-01

    Full text: Nuclear safety is a never ending pursuit for improvement, and one of the more prominent IAEA efforts that help Member States achieve higher levels of safety is the Operational Safety Review Team (OSART) programme. In OSART missions, the IAEA coordinates internationally-based teams of experts who conduct reviews of operational safety performance at nuclear power plants. The IAEA on 14 June 2013 marked the 30th anniversary of OSART. In 1983, the Agency conducted its first OSART mission to the Kori Nuclear Power Plant in the Republic of Korea, and it conducted a total of 174 OSART missions over the following 30 years. The reviews have been done in 34 nations at 103 nuclear sites. (author)

  5. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996. Photo 01: Raymond Battistella - Director-General of SIG, Geneva's utilities provider (left) - and Bernard Ecoffey, Founder of the Forum Engelberg. In the background is the CMS magnet system under construction. The red concentric rings are part of the barrel yoke, which returns the magnetic flux generated by the superconducting coil. Supported from the innermost barrel ring is the outer cylinder of the vacuum tank that will house the superconducting coil. Photo 02: Alexander Höchli, member of the Institutional Committee of Forum Engelberg and former Landammann of the canton of Obwalden (left), with Raymond Battistella, Di...

  6. APPARATUS FOR NON-DESTRUCTIVE INSPECTION OF CANTILEVERED MEMBERS

    Science.gov (United States)

    Taylor, E.R.; Mahoney, C.H.; Lay, C.R.

    1961-10-24

    An apparatus for non-destructive inspection of cantilevered members, such as compressor blades, is described. The member under inspection is vibrated with a regulated source of air under pressure. The amplitude of vibration of the member is maintained at its natural frequency. The frequency of vibration of the member is measured. An indication of an excessive decay or erratic shifting in the measured frequency above an allowable hysteretic decay is provided as an indication of a fault in the member. The member is vibrated for a selected test period. (AEC)

  7. Perspectives and expectations of union member and non- union member teachers on teacher unions

    Directory of Open Access Journals (Sweden)

    Tuncer FİDAN

    2015-12-01

    Full Text Available Unions, which can be regarded as one of the constitutive elements of democracy, are the pressure groups in political and social fields. Unions were born out of industrial confrontations and expanded into the field of public services over time, and thus teachers – who are also public employees-, also obtained the right to establish and affiliate to unions. In this research the views of union member and non-union member teachers on the most important functions and operational effectiveness of unions, teachers’ expectations from unions and teachers’ evaluation of the solidarity, competition and cooperation between unions were determined and the perspectives of teachers on unionization were revealed. qualitative research design was used. The data needed were collected through semi-structured interviews from volunteering union member and non-union member teachers who were working in the primary and secondary schools in Ankara province and who were selected through “maximum variation sampling approach”. The data were then analyzed by using the content analysis technique. In conclusion, it was found that political ideology was the most important reason for membership of teachers’ unions. Protection and development of personal rights was found to be the most important function of teacher unions and unions were thought to be insufficient in performing those functions.

  8. Family Members' Reports of the Technology Use of Family Members with Intellectual and Developmental Disabilities

    Science.gov (United States)

    Palmer, S. B.; Wehmeyer, M. L.; Davies, D. K.; Stock, S. E.

    2012-01-01

    Background: A nationwide survey of family members of people with intellectual and developmental disabilities ranging in age from birth through adulthood was conducted to replicate a similar effort by Wehmeyer and update the knowledge base concerning technology use by people with intellectual and developmental disabilities. Method: Survey responses…

  9. Inflation persistence: is it similar in the new EU member states and the euro area members?

    Czech Academy of Sciences Publication Activity Database

    Franta, Michal; Saxa, Branislav; Šmídková, K.

    -, 25/2008 (2008), s. 1-35 Grant - others:Česká národní banka(CZ) B4/2003 Institutional research plan: CEZ:AV0Z70850503 Keywords : inflation persistence * new EU member states * new hybrid Phillips curve Subject RIV: AH - Economics http://ies.fsv.cuni.cz/default/file/download/id/9070

  10. Inflation persistence in new EU member states: is it different than in the euro area members?

    Czech Academy of Sciences Publication Activity Database

    Franta, Michal; Saxa, Branislav; Šmídková, Kateřina

    -, č. 10 (2007), s. 1-37 ISSN 1803-2397 Institutional research plan: CEZ:AV0Z70850503 Keywords : inflation persistence * new hybrid Phillips curve * new EU member states Subject RIV: AH - Economics http://www.cnb.cz/m2export/sites/www.cnb.cz/en/research/research_publications/cnb_wp/download/cnbwp_2007_10.pdf

  11. Ten Warning Signs Your Older Family Member May Need Help

    Science.gov (United States)

    ... Warning Signs Your Older Family Member May Need Help Changes in physical and cognitive abilities that may ... and their family members, friends, and caregivers. To help in determining when an older adult may need ...

  12. 48 CFR 6301.2 - Qualifications of members.

    Science.gov (United States)

    2010-10-01

    ... contract law. ... CONTRACT APPEALS BOARD OF CONTRACT APPEALS 6301.2 Qualifications of members. Each member of the Board must... administrative law judges appointed pursuant to section 3105 of title 5 of the United States Code, with the...

  13. Training Needs of Cooperative Members and Marketing of ...

    African Journals Online (AJOL)

    Training Needs of Cooperative Members and Marketing of Agricultural Products in Akwa Ibom State, Nigeria. ... of multi-purpose cooperative society members and the marketing of agricultural products ... EMAIL FULL TEXT EMAIL FULL TEXT

  14. 78 FR 28243 - Senior Executive Service; Performance Review Board; Members

    Science.gov (United States)

    2013-05-14

    ... NATIONAL CAPITAL PLANNING COMMISSION Senior Executive Service; Performance Review Board; Members AGENCY: National Capital Planning Commission. ACTION: Notice of Members of Senior Executive Service... Senior Executive Service. The PRB established for the National Capital Planning Commission also makes...

  15. 76 FR 29013 - Senior Executive Service; Performance Review Board; Members

    Science.gov (United States)

    2011-05-19

    ... NATIONAL CAPITAL PLANNING COMMISSION Senior Executive Service; Performance Review Board; Members AGENCY: National Capital Planning Commission. ACTION: Notice of Members of Senior Executive Service... Senior Executive Service. The PRB established for the National Capital Planning Commission also makes...

  16. Members of FOX family could be drug targets of cancers.

    Science.gov (United States)

    Wang, Jinhua; Li, Wan; Zhao, Ying; Kang, De; Fu, Weiqi; Zheng, Xiangjin; Pang, Xiaocong; Du, Guanhua

    2018-01-01

    FOX families play important roles in biological processes, including metabolism, development, differentiation, proliferation, apoptosis, migration, invasion and longevity. Here we are focusing on roles of FOX members in cancers, FOX members and drug resistance, FOX members and stem cells. Finally, FOX members as drug targets of cancer treatment were discussed. Future perspectives of FOXC1 research were described in the end. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Ombuds' Corner: Users and Staff Members

    CERN Multimedia

    Vincent Vuillemin

    2010-01-01

    In this series, the Bulletin aims to explain the role of the Ombuds at CERN by presenting practical examples of misunderstandings that could have been resolved by the Ombuds if he had been contacted earlier. Please note that, in all the situations we present, the names are fictitious and used only to improve clarity. 
     Pam* and Jeff* are both physicists working on the same project for an experiment. Pam is from a collaborating institute and Jeff is a CERN staff member. As the project is being developed at CERN they both share the same technical support available in the Laboratory. At the beginning they organised themselves so they could get the support that both of them needed. When some milestones concerning the delivery of parts became urgent, they started to actually compete for the same resources, which could not possibly satisfy all requests at the same time. With the time pressure increasing, Jeff started to accuse Pam of diverting the resources for her own share of the proj...

  18. TO ALL MEMBERS OF THE PERSONNEL

    CERN Document Server

    2001-01-01

    During the period mid-June to mid-September 2001, there will be a limited number of vacancies for temporary work at CERN (normally unskilled work of a routine nature) which will be made available to children of members of the personnel (that is, anyone holding an employment or association contract with CERN). It should be noted that candidates must be aged between 18 and 24 inclusive on the first day of the contract, and that they must have insurance cover for both illness and accident. In view of the limited number of vacancies available, no children previously appointed at CERN under this scheme can be considered. The duration of all appointments will be 4 weeks, the allowance being CHF 1538.- net for this period. Application forms can be obtained via the Web at the following address: http://cern.web.cern.ch/CERN/Divisions/PE/ under the heading 'Other Useful Links' or from Paula Barriere, Personnel Management Group (by using the slip below or by electronic mail to Paula.Barriere@.cern.ch). Completed applic...

  19. The relationship between mental health workers and family members

    NARCIS (Netherlands)

    van de Bovenkamp, H.M.; Trappenburg, M.J.

    2010-01-01

    Objective To study the relationship between family members and mental health care workers to learn more about the support available to family members of mental health patients. Methods Eighteen interviews were conducted with family members, seven with professionals and two with patients.

  20. Using artificial team members for team training in virtual environments

    NARCIS (Netherlands)

    Diggelen, J. van; Muller, T.; Bosch, K. van den

    2010-01-01

    In a good team, members do not only perform their individual task, they also coordinate their actions with other members of the team. Developing such team skills usually involves exercises with all members playing their role. This approach is costly and has organizational and educational drawbacks.

  1. Party member recruitment and the representativeness of party membership

    DEFF Research Database (Denmark)

    Kosiara-Pedersen, Karina

    Party membership figures are in decline. However, parties are still recruiting party members. Are there any differences in the social and political characteristics of old and new party members? If there is a difference, are new party members more or less representative for party voters than old...

  2. Mental Wellbeing of Family Members of Autistic Adults

    Science.gov (United States)

    Herrema, Renske; Garland, Deborah; Osborne, Malcolm; Freeston, Mark; Honey, Emma; Rodgers, Jacqui

    2017-01-01

    Family members are often the primary caregiver for autistic adults and this responsibility may impact on the carer's wellbeing and quality of life. 109 family members of autistic adults completed an online survey assessing their wellbeing relating to their caring role for their autistic relative. Family members who were supporting an autistic…

  3. 21 CFR 13.10 - Members of a Board.

    Science.gov (United States)

    2010-04-01

    ... BEFORE A PUBLIC BOARD OF INQUIRY General Provisions § 13.10 Members of a Board. (a) All members of a... to be free from bias or prejudice concerning the issues involved. A member of a Board may be a full...

  4. 29 CFR 1400.735-19 - Influencing Members of Congress.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Influencing Members of Congress. 1400.735-19 Section 1400... Responsibilities § 1400.735-19 Influencing Members of Congress. No money appropriated to the Service shall be used... devices intended to influence any Member of Congress regarding any legislation or appropriation before the...

  5. 38 CFR 1.507 - Disclosures to members of Congress.

    Science.gov (United States)

    2010-07-01

    ... Congress. 1.507 Section 1.507 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS... Disclosures to members of Congress. Members of Congress shall be furnished in their official capacity in any... which may not be furnished a claimant, the member of Congress shall be advised that the information is...

  6. 48 CFR 1305.403 - Requests from Members of Congress.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Requests from Members of Congress. 1305.403 Section 1305.403 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE... from Members of Congress. Requests from Members of Congress shall be handled in accordance with the...

  7. 45 CFR 703.9 - Reimbursement of members.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Reimbursement of members. 703.9 Section 703.9... AND FUNCTIONS OF STATE ADVISORY COMMITTEES § 703.9 Reimbursement of members. (a) Advisory Committee members may be reimbursed by the Commission by a per diem subsistence allowance and for travel expenses at...

  8. 49 CFR 805.735-10 - Member and employee indebtedness.

    Science.gov (United States)

    2010-10-01

    ... TRANSPORTATION SAFETY BOARD EMPLOYEE RESPONSIBILITIES AND CONDUCT § 805.735-10 Member and employee indebtedness. Members and employees shall pay each just financial obligation in a proper and timely manner, especially... 49 Transportation 7 2010-10-01 2010-10-01 false Member and employee indebtedness. 805.735-10...

  9. Insider Research with Family Members who have a Member Living with Rare Cancer

    Directory of Open Access Journals (Sweden)

    Jan Foster PhD

    2009-12-01

    Full Text Available In this article the author explores insider research in relation to family members facing a diagnosis of rare cancer, using her experiences as one such family member undertaking doctoral research into journeys similar to hers. The “insider” issue is explored through three realms: the ethical realm, including issues of “fitness” to undertake the research; the methodological realm, including how data are obtained and used; and the trustworthiness realm, including research rigor. The exploration of her insider experiences includes personal challenges in relation to facing familiar emotionally charged experiences, insights gained as a result of her insider status, and her ability to join with participants in ways that might not be possible for an outsider. In the paper the author challenges taken-for-granted assumptions that trustworthiness can be assured only from the position of “objective” researcher. Rather, this analysis places knowledge gained through the processes and products of research as constituted and contextualized.

  10. VizieR Online Data Catalog: NGC 6802 dwarf cluster members and non-members (Tang+, 2017)

    Science.gov (United States)

    Tang, B.; Geisler, D.; Friel, E.; Villanova, S.; Smiljanic, R.; Casey, A. R.; Randich, S.; Magrini, L.; San, Roman I.; Munoz, C.; Cohen, R. E.; Mauro, F.; Bragaglia, A.; Donati, P.; Tautvaisiene, G.; Drazdauskas, A.; Zenoviene, R.; Snaith, O.; Sousa, S.; Adibekyan, V.; Costado, M. T.; Blanco-Cuaresma, S.; Jimenez-Esteban, F.; Carraro, G.; Zwitter, T.; Francois, P.; Jofre, P.; Sordo, R.; Gilmore, G.; Flaccomio, E.; Koposov, S.; Korn, A. J.; Lanzafame, A. C.; Pancino, E.; Bayo, A.; Damiani, F.; Franciosini, E.; Hourihane, A.; Lardo, C.; Lewis, J.; Monaco, L.; Morbidelli, L.; Prisinzano, L.; Sacco, G.; Worley, C. C.; Zaggia, S.

    2016-11-01

    The dwarf stars in NGC 6802 observed by GIRAFFE spectrograph are separated into four tables: 1. cluster members in the lower main sequence; 2. cluster members in the upper main sequence; 3. non-member dwarfs in the lower main sequence; 4. non-member dwarfs in the upper main sequence. The star coordinates, V band magnitude, V-I color, and radial velocity are given. (4 data files).

  11. 19 CFR 122.75b - Electronic manifest requirement for crew members and non-crew members onboard commercial aircraft...

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Electronic manifest requirement for crew members... THE TREASURY AIR COMMERCE REGULATIONS Documents Required for Clearance and Permission To Depart; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial...

  12. Prevalence, Knowledge and Attitudes Towards Smoking Among SEPAR Members.

    Science.gov (United States)

    Solano Reina, Segismundo; Jiménez Ruiz, Carlos A; de Higes Martinez, Eva; Garcia Rueda, Marcos; Callejas González, Francisco J; de Granda Orive, Jose I; Vaquero Lozano, Paz; de Lucas Ramos, Pilar; Alfageme Michavila, Inmaculada

    2016-12-01

    The aims of this study were to estimate the prevalence of smoking among SEPAR members, and their approach to smoking cessation in their patients. An online survey was completed by 640 members (496 pulmonologists, 45 nurses, 34 thoracic surgeons, 37 physiotherapists, and 28 other specialists). Of the members interviewed, 5% confessed that they were smokers: 3.5% pulmonologists; 8.9% nurses; 8.8% thoracic surgeons, and 13.5% physiotherapists. A total of 96% of members assign a lot or quite a lot of importance to setting an example; 98% of members always or often ask their patients about their smoking habit. The most effective anti-smoking intervention, according to 77% of members, is a combination of drugs and psychological support. These results are an indicator of the awareness and commitment of SEPAR members to smoking and its cessation. Copyright © 2016 SEPAR. Publicado por Elsevier España, S.L.U. All rights reserved.

  13. Paraoxonases: ancient substrate hunters and their evolving role in ischemic heart disease.

    Science.gov (United States)

    Martinelli, Nicola; Consoli, Letizia; Girelli, Domenico; Grison, Elisa; Corrocher, Roberto; Olivieri, Oliviero

    2013-01-01

    Interest in the role of paraoxonases (PON) in cardiovascular research has increased substantially over the past two decades. These multifaceted and pleiotropic enzymes are encoded by three highly conserved genes (PON1, PON2, and PON3) located on chromosome 7q21.3-22.1. Phylogenetic analysis suggests that PON2 is the ancient gene from which PON1 and PON3 arose via gene duplication. Although PON are primarily lactonases with overlapping, but distinct specificities, their physiologic substrates remain poorly characterized. The most interesting characteristic of PON, however, is their multifunctional roles in various biochemical pathways. These include protection against oxidative damage and lipid peroxidation, contribution to innate immunity, detoxification of reactive molecules, bioactivation of drugs, modulation of endoplasmic reticulum stress, and regulation of cell proliferation/apoptosis. In general, PON appear as "hunters" of old and new substrates often involved in athero- and thrombogenesis. Although reduced PON activity appears associated with increased cardiovascular risk, the correlation between PON genotype and ischemic heart disease remains controversial. In this review, we examine the biochemical pathways impacted by these unique enzymes and investigate the potential use of PON as diagnostic tools and their impact on development of future therapeutic strategies.

  14. Neuro-protective effect of rutin against Cisplatin-induced neurotoxic rat model.

    Science.gov (United States)

    Almutairi, Mashal M; Alanazi, Wael A; Alshammari, Musaad A; Alotaibi, Moureq Rashed; Alhoshani, Ali R; Al-Rejaie, Salim Salah; Hafez, Mohamed M; Al-Shabanah, Othman A

    2017-09-29

    Cisplatin is widely used chemotherapeutic agent for cancer treatment with limited uses due to its neurotoxic side effect. The aim of this study was to determine the potential preventive effects of rutin on the brain of cisplatin- neurotoxic rat model. Forty rats were divided into four groups. Group-1 (control group) was intra-peritoneal (IP) injected with 2.5 ml/kg saline. Group-2 (rutin group) was orally administrated 30 mg/kg rutin dissolved in water for 14 days. Group-3 (cisplatin group) was IP received 5 mg/kg cisplatin single dose. Group-4 (rutin and cisplatin group) was orally administrated 30 mg/kg rutin dissolved in water for 14 days with a single dose of 5 mg/kg cisplatin IP on day ten. Brain tissues from frontal cortex was used to extract RNA, the gene expression levels of paraoxonase-1 (PON-1), PON-2, PON-3, peroxisome proliferator-activated receptor delta (PPAR-δ), and glutathione peroxidase (GPx) was investigated by Real-time PCR. Cisplatin significantly decreased the expression levels of PON-1, PON-3, PPAR-δ and GPX whereas significantly increased PON-2 expression levels. Co-administration of Rutin prevented the cisplatin-induced toxicity by restoring the alteration in the studied genes to normal values as in the control group. This study showed that Rutin has neuroprotective effect and reduces cisplatin- neurotoxicity with possible mechanism via the antioxidant pathway.

  15. Nurse IOM members' contributions to the Institute of Medicine.

    Science.gov (United States)

    Grey, Margaret; Holzemer, William L; Larson, Elaine

    2012-01-01

    Nursing is the largest health care profession, and Institute of Medicine (IOM) nurse members have the potential to contribute to health policy through IOM activities. We studied reported activities of IOM nurse members. To describe activities of IOM nurse members within the IOM. An e-mail survey was conducted that asked nurse IOM members to assess self-reported IOM activities. Of 57 members, 47 had functioning e-mail addresses, and 33 usable responses were received. The survey consisted of 9 questions dealing with roles and responsibilities undertaken in the previous 5 years. Data analyses were descriptive. The data suggest that nurses have made considerable contributions to the IOM and their participation seems to be as high, or higher, than other disciplines. In an era of health care reform, there is additional opportunity for nurse IOM members to enhance their work in the IOM. Copyright © 2012 Elsevier Inc. All rights reserved.

  16. Recent advances in the field of 16-membered macrolide antibiotics.

    Science.gov (United States)

    Cui, W; Ma, S

    2011-10-01

    The continuing emergence of bacterial resistance has provided an incentive for recent intensified research on macrolide antibiotics. Belonging to the macrolide family, 16-membered macrolides also experience a renewed interest in further exploration. The medicinal potential of 16-membered macrolides in search for new antibacterials stems from some advantages over 14-membered macrolides, such as gastrointestinal tolerability, structural flexibility, and lack of inducible resistance. Thus, compared with abundant articles on various 14-membered macrolide derivatives in the literature, this review will highlight some representative 16-membered macrolide antibiotics and their recently discovered analogs. Furthermore, the action and resistance mechanisms of 16-membered macrolide antibiotics will be elucidated as well to assist the drug design.

  17. Measurement and comparison of nursing faculty members' critical thinking skills.

    Science.gov (United States)

    Blondy, Laurie C

    2011-03-01

    Nursing faculty members strive to teach students to think critically. It has long been assumed that nursing faculty members are good at critical thinking because they are expected to teach these skills to students, but this assumption has not been well supported empirically. Faculty members question their ability to think critically and are unsure of their skills. The purpose of this study was to address this assumption by measuring nursing faculty members' critical thinking skills and compare the faculty mean score to that of a student norming group, and to the mean scores of other nursing faculty studies. Findings can be used to increase nursing faculty members' understanding of their critical thinking skills, prompt discussion about critical thinking skills, and to help faculty members address concerns and uncertainty about the concept of critical thinking. This study also helps establish an empirical basis for future research.

  18. Netball team members, but not hobby group members, distinguish team characteristics from group characteristics.

    Science.gov (United States)

    Stillman, Jennifer A; Fletcher, Richard B; Carr, Stuart C

    2007-04-01

    Research on groups is often applied to sport teams, and research on teams is often applied to groups. This study investigates the extent to which individuals have distinct schemas for groups and teams. A list of team and group characteristics was generated from 250 individuals, for use in this and related research. Questions about teams versus groups carry an a priori implication that differences exist; therefore, list items were presented to new participants and were analyzed using signal detection theory, which can accommodate a finding of no detectable difference between a nominated category and similar items. Participants were 30 members from each of the following: netball teams, the general public, and hobby groups. Analysis revealed few features that set groups apart from teams; however, teams were perceived as more structured and demanding, requiring commitment and effort toward shared goals. Team and group characteristics were more clearly defined to team members than they were to other participant groups. The research has implications for coaches and practitioners.

  19. IDENTIFYING COMPETENCIES OF VOLUNTEER BOARD MEMBERS OF COMMUNITY SPORTS CLUBS

    OpenAIRE

    A. BALDUCK; A. VAN ROSSEM; M. BUELENS

    2009-01-01

    This study contributes to the emerging empirical studies on roles and responsibilities of boards in nonprofit organizations by identifying competencies of volunteer board members. We identified how two types of constituents—volunteer board members and sports members—perceived competencies of volunteer board members in community sports clubs. We used the repertory grid technique to draw cognitive maps and to reveal the perceived reality of these constituents. Our results suggest that constitue...

  20. Fuel safety criteria in NEA member countries - Compilation of responses received from member countries

    International Nuclear Information System (INIS)

    2003-03-01

    In 2001 the Committee on the Safety of Nuclear Installations (CSNI) issued a report on Fuel Safety Criteria Technical Review. The objective was to review the present fuel safety criteria and judge to which extent they are affected by the 'new' design elements, such as different cladding materials, higher burnup, the use of MOX fuels, etc. The report stated that the current framework of fuel safety criteria remains generally applicable, being largely unaffected by the 'new' or modern design elements. The levels (numbers) in the individual safety criteria may, however, change in accordance with the particular fuel and core design features. Some of these levels have already been - or are continuously being - adjusted. The level adjustments of several other criteria (RIA, LOCA) also appears to be needed, on the basis of experimental data and the analysis thereof. As a follow-up, among its first tasks, the CSNI Special Expert Group on Fuel Safety Margins (SEG FSM) initiated the collection of information on the present fuel safety criteria used in NEA member states with the objective to solicit national practices in the use of fuel safety criteria, in particular to get information on their specific national levels/values, including their recent adjustments, and to identify the differences and commonalties between the different countries. Two sources of information were used to produce this report: a compilation of responses to a questionnaire prepared for the June 2000 CNRA meeting, and individual responses from the SEGFSM members to the new revised questionnaire issued by the task Force preparing this report. In accordance with the latter, the fuel safety criteria discussed in this report were divided into three categories: (A) safety criteria - criteria imposed by the regulator; (B) operational criteria - specific to the fuel design and provided by the fuel vendor as part of the licensing basis; (C) design criteria - limits employed by vendors and/or utilities for fuel

  1. Scientific collaboration between 'old' and 'new' member states

    DEFF Research Database (Denmark)

    Makkonen, Teemu; Mitze, Timo Friedel

    2016-01-01

    following the two enlargement waves 2004 and 2007 has significantly increased the co-publication intensity of the new member states with other member countries. The empirical results based on data collected from the Web of Science database and Difference-in-Difference estimations point towards a conclusion...... that joining the EU indeed has had an additional positive impact on the co-publication intensity between the new and old member states and, in particular, between the new member states themselves. These results give tentative support for the successfulness of the EU’s science policies in achieving a common...

  2. Flame-Resistant Composite Materials For Structural Members

    Science.gov (United States)

    Spears, Richard K.

    1995-01-01

    Matrix-fiber composite materials developed for structural members occasionally exposed to hot, corrosive gases. Integral ceramic fabric surface layer essential for resistance to flames and chemicals. Endures high temperature, impedes flame from penetrating to interior, inhibits diffusion of oxygen to interior where it degrades matrix resin, resists attack by chemicals, helps resist erosion, and provides additional strength. In original intended application, composite members replace steel structural members of rocket-launching structures that deteriorate under combined influences of atmosphere, spilled propellants, and rocket exhaust. Composites also attractive for other applications in which corrosion- and fire-resistant structural members needed.

  3. Posttraumatic stress disorder in women with war missing family members.

    Science.gov (United States)

    Baraković, Devla; Avdibegović, Esmina; Sinanović, Osman

    2014-12-01

    Research in crisis areas indicate that survivors' responses to the forced disappearance of family members are similar to reactions to other traumatic events. The aim of this study was to determine the presence of symptoms of posttraumatic stress disorder (PTSD) in women with war missing family members in Bosnia and Herzegovina 18 years after the war in this region (1992-1995). The study included 160 women aged 47.1±14.0 from three regions of Bosnia and Herzegovina. It was carried out in the period from April 2010 to May 2011. Of the 160 participants, 120 women had a war missing family member and 40 women had no war missing family members. The Harvard Trauma Questionnaire (HTQ), the Beck Depression Inventory (BDI) and the Hamilton Anxiety Rating Scale (HAMA) were used for data collection. Basic socio-demographic data and data concerning the missing family members were also collected. Women with war missing family members experienced significantly more traumatic war experiences (18.43±5.27 vs 6.57±4.34, pfamily members. Women with war missing family members showed significantly more severe PTSD symptoms. Based on the results of this study, it was determined that the forced disappearance of a family member is an ambiguous situation that can be characterized as a traumatic experience.

  4. An Analysis of Generational Differences Among Active Duty Members

    National Research Council Canada - National Science Library

    Skibo, Stephanie

    2004-01-01

    .... Clearly, these observed differences have implications for managers and leaders. Actions taken by leaders might be misunderstood by junior organizational members, leading to undesirable outcomes...

  5. E-Commerce in OIC members: Facts - Challenges - Prospects

    OpenAIRE

    Al-Abdali, Abid

    2005-01-01

    The study seeks to explore the importance of E-Commerce and ICT and their impact on economies of OIC members. Challenges and obstacles of E-Commerce application in member states are analyzed and discussed. The study has concluded that E-Commerce has become an important application in most member states. It also showed that despite there has been growth in the application of E-Commerce in some countries, but in general OIC members as a whole are still behind in the track compared to other grou...

  6. TEACHING IN ONLINE COURSES: Experiences of Instructional Technology Faculty Members

    Directory of Open Access Journals (Sweden)

    Omur AKDEMIR

    2008-04-01

    Full Text Available The Internet and computer technology have altered the education landscape. Online courses are offered throughout the world. Learning about the experiences of faculty members is important to guide practitioners and administrators. Using qualitative research methodology, this study investigated the experiences of faculty members teaching online courses. A convenience sampling was used to select the instructional technology faculty members to investigate their experiences in online courses. Semi-structured interviews with faculty members teaching online courses were used as the primary source to collect data about the experiences of faculty members in online courses. Results of the study showed that faculty members' interest in using technology and the amount of time available to them for online course design affected the quality of online courses. The findings of this study also indicated that design quality of online courses is affected by the interest of faculty members to use the technology and the time that they can devote to planning, designing, and developing online courses. The poor design of existing online courses, high learning expectations of ndividuals from these courses, and the future of online courses are the concerns of faculty members. Higher education institutions should support workshops and trainings to increase the skills and interests of non-instructional design faculty members to design and develop online courses.

  7. Expanding access to naloxone for family members: The Massachusetts experience.

    Science.gov (United States)

    Bagley, Sarah M; Forman, Leah S; Ruiz, Sarah; Cranston, Kevin; Walley, Alexander Y

    2018-05-01

    The Massachusetts Department of Public Health Overdose Education and Naloxone Distribution Program provides overdose education and naloxone rescue kits to people at risk for overdose and bystanders, including family members. Using Massachusetts Department of Public Health data, the aims are to: (i) describe characteristics of family members who receive naloxone; (ii) identify where family members obtain naloxone; and (iii) describe characteristics of rescues by family members. We conducted a retrospective review using program enrollee information collected on a standardised form between 2008 and 2015. We calculated descriptive statistics, including demographics, current substance use, enrolment location, history of witnessed overdoses and rescue attempt characteristics. We conducted a stratified analysis comparing family members who used drugs with those who did not. Family members were 27% of total program enrollees (n = 10 883/40 801). Family members who reported substance use (n = 4679) were 35.6 years (mean), 50.6% female, 76.3% non-Hispanic white, 75.6% had witnessed an overdose, and they obtained naloxone most frequently at HIV prevention programs. Family members who did not report substance use (n = 6148) were 49.2 years (mean), 73.8% female, 87.9% non-Hispanic white, 35.3% had witnessed an overdose, and they obtained naloxone most frequently at community meetings. Family members were responsible for 20% (n = 860/4373) of the total rescue attempts. The Massachusetts experience demonstrates that family members can be active participants in responding to the overdose epidemic by rescuing family members and others. Targeted intervention strategies for families should be included in efforts to expand overdose education and naloxone in Massachusetts. © 2017 Australasian Professional Society on Alcohol and other Drugs.

  8. Marketing Strategies for Recruiting 4-H Members in West Virginia.

    Science.gov (United States)

    Wingenbach, Gary J.; Nestor, Cheryl; Lawrence, Layle D.; Gartin, Stacy A.; Woloshuk, Jean; Mulkeen, Patricia

    2000-01-01

    According to a survey of 174 West Virginia 4-H members aged 13-18, the Internet and word of mouth were most effective in recruiting new members. Active messages stressing camps, fun, and friendship had the most influence on retention. A statewide marketing plan was recommended. (SK)

  9. Problems and Counselling Needs of Corps Members in Nigeria (Pp ...

    African Journals Online (AJOL)

    Nekky Umera

    1973-05-22

    May 22, 1973 ... major problems and counseling needs of Corps Members were psychological in nature. ... and must be resolved sufficiently at a given stage if the individual is to cope successfully with ... (ii) Is there any difference between the problems of male and female ... youth corps member of different age group?

  10. The New Faculty Members' Concerns: The Case of Jordanian Universities

    Science.gov (United States)

    Qudais, Mahmoud Abu; Al-Omari, Aieman; Smadi, Rana

    2009-01-01

    The present study aimed to identify and interpret concerns of the new faculty members in Jordanian universities. A total of 336 new faculty members who participated in this study were asked to rate their perceptions of issues related to teaching, research, service, balancing work and home life and the academic culture of their workplace. Means and…

  11. Perceived Family Resources Based on Number of Members with ADHD

    Science.gov (United States)

    Corwin, Melinda; Mulsow, Miriam; Feng, Du

    2012-01-01

    Objective: This study examines how the number of family members with ADHD affects other family members' perceived resources. Method: A total of 40 adolescents diagnosed with ADHD and their mothers, fathers, and adolescent siblings living in the household participated. Hierarchical linear modeling was used to analyze family-level data from a total…

  12. Easy access to 6-membered iminoalditols - important glycosidase inhibitors

    DEFF Research Database (Denmark)

    Lundt, Inge

    of 6-membered iminoalditols were observed. The use of triethylamine in methanol thus gave methylesters of 6-membered iminouronic acids. Reduction of the ester group with sodium borohydride gave the target compounds. The mechanisms of the reactions will be discussed as well as specific results obtained...

  13. Union members at the polls in diverse trade union landscapes

    DEFF Research Database (Denmark)

    Arndt, Christoph; Rennwald, Line

    2016-01-01

    still enjoy important support from trade union members, but at the same time are under fierce competition from bourgeois and green parties among members of white-collar confederations. This reinforces the challenges for social democracy to build new voters’ coalitions in post-industrial societies....

  14. Understanding the Everyday Practice of Individualized Education Program Team Members

    Science.gov (United States)

    Hartmann, Elizabeth S.

    2016-01-01

    The Individuals with Disabilities Education Improvement Act of 2004 states that individualized education program (IEP) teams are composed of members with distinct identities, roles, expertise, and histories. Although team members must work together to implement educational and related services for learners with special needs, little is known about…

  15. Support for Teens When a Family Member has Cancer

    Science.gov (United States)

    When a parent, brother, or sister has been diagnosed with cancer, family members need extra support. Information to help teens learn how to cope, talk with family members, manage stress, and get support from counselors when a loved one has been diagnosed with, or is being treated for, cancer.

  16. Space strategy and governance of ESA small member states

    Science.gov (United States)

    Sagath, Daniel; Papadimitriou, Angeliki; Adriaensen, Maarten; Giannopapa, Christina

    2018-01-01

    The European Space Agency (ESA) has twenty-two Member States with a variety of governance structures and strategic priorities regarding their space activities. The objective of this paper is to provide an up-to date overview and a holistic assessment of the national space governance structures and strategic priorities of the eleven smaller Member States (based on annual ESA contributions). A link is made between the governance structure and the main strategic objectives. The specific needs and interests of small and new Member States in the frame of European Space Integration are addressed. The first part of the paper focuses on the national space governance structures in the eleven smaller ESA Member States. The governance models of these Member States are identified including the responsible ministries and the entities entrusted with the implementation of space strategy/policy and programmes of the country. The second part of this paper focuses on the content and analysis of the national space strategies and indicates the main priorities and trends in the eleven smaller ESA Member States. The priorities are categorised with regards to technology domains, the role of space in the areas of sustainability and the motivators for space investments. In a third and final part, attention is given to the specific needs and interests of the smaller Member States in the frame of European space integration. ESA instruments are tailored to facilitate the needs and interests of the eleven smaller and/or new Member States.

  17. 1978-79 Directory of Physics & Astronomy Staff Members.

    Science.gov (United States)

    American Inst. of Physics, New York, NY.

    This directory gives names, addresses, and telephone numbers of staff members of astronomy and physics departments. The listings are made under the following headings: (1) American Institute of Physics and its member societies; (2) geographic listing of academic institutions and faculty - U.S., Canada, Mexico, and Central America; (3) U.S.…

  18. Evolution properties of the community members for dynamic networks

    Science.gov (United States)

    Yang, Kai; Guo, Qiang; Li, Sheng-Nan; Han, Jing-Ti; Liu, Jian-Guo

    2017-03-01

    The collective behaviors of community members for dynamic social networks are significant for understanding evolution features of communities. In this Letter, we empirically investigate the evolution properties of the new community members for dynamic networks. Firstly, we separate data sets into different slices, and analyze the statistical properties of new members as well as communities they joined in for these data sets. Then we introduce a parameter φ to describe community evolution between different slices and investigate the dynamic community properties of the new community members. The empirical analyses for the Facebook, APS, Enron and Wiki data sets indicate that both the number of new members and joint communities increase, the ratio declines rapidly and then becomes stable over time, and most of the new members will join in the small size communities that is s ≤ 10. Furthermore, the proportion of new members in existed communities decreases firstly and then becomes stable and relatively small for these data sets. Our work may be helpful for deeply understanding the evolution properties of community members for social networks.

  19. 48 CFR 605.403 - Requests from members of Congress.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Requests from members of Congress. 605.403 Section 605.403 Federal Acquisition Regulations System DEPARTMENT OF STATE COMPETITION... members of Congress. The Procurement Executive is the agency head for the purposes of FAR 5.403. [59 FR...

  20. 5 CFR 842.209 - Members of Congress.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Members of Congress. 842.209 Section 842.209 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES RETIREMENT SYSTEM-BASIC ANNUITY Eligibility § 842.209 Members of Congress. (a...

  1. 48 CFR 405.403 - Requests from Members of Congress.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Requests from Members of Congress. 405.403 Section 405.403 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE... Members of Congress. The head of the contracting activity (HCA) is the agency head designee pursuant to...

  2. 48 CFR 1405.403 - Requests from Members of Congress.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Requests from Members of Congress. 1405.403 Section 1405.403 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR... from Members of Congress. For purposes of this subpart, the agency head is the HCA with the power of...

  3. 48 CFR 2905.403 - Requests from Members of Congress.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Requests from Members of Congress. 2905.403 Section 2905.403 Federal Acquisition Regulations System DEPARTMENT OF LABOR ACQUISITION PLANNING PUBLICIZING CONTRACT ACTIONS Release Of Information 2905.403 Requests from Members of Congress...

  4. Analysis of Member State RED implementation. Final Report (Task 2)

    Energy Technology Data Exchange (ETDEWEB)

    Peters, D.; Alberici, S.; Toop, G. [Ecofys, Utrecht (Netherlands); Kretschmer, B. [Institute for European Environmental Policy IEEP, London (United Kingdom)

    2012-12-15

    This report describes the way EU Member States have transposed the sustainability and chain of custody requirements for biofuels as laid down in the Renewable Energy Directive (RED) and Fuel Quality Directive (FQD). In the assessment of Member States' implementation, the report mainly focuses on effectiveness and administrative burden. Have Member States transposed the Directives in such a way that compliance with the sustainability criteria can be ensured as effectively as possible? To what extent does the Member States' implementation lead to unnecessary administrative burden for economic operators in the (bio)fuel supply chain? The report focuses specifically on the transposition of the sustainability and chain of custody requirements, not on the target for renewables on transport. This means that for example the double counting provision is not included as part of the scope of this report. This report starts with an introduction covering the implementation of the Renewable Energy (and Fuel Quality) Directive into national legislation, the methodology by which Member States were assessed against effectiveness and administrative burden and the categorisation of Member State's national systems for RED-implementation (Chapter 1). The report continues with a high level description of each Member State system assessed (Chapter 2). Following this, the report includes analysis of the Member States on the effectiveness and administrative burden of a number of key ('major') measures (Chapter 3). The final chapter presents the conclusions and recommendations (Chapter 4)

  5. Faculty Member Perceptions of Academic Leadership Styles at Private Colleges

    Science.gov (United States)

    Gidman, Lori Kathleen

    2013-01-01

    The leadership style of academic leaders was studied through the eyes of faculty members. This empirical study looked at faculty perceptions of academic leadership with the use of a numerical survey as the basis for observation. Faculty members at six private liberal arts institutions completed the Multifactor Leadership Questionnaire (MLQ) in…

  6. Influence of group member familiarity on online collaborative learning

    NARCIS (Netherlands)

    Janssen, J.J.H.M.; Erkens, G.; Kirschner, P.A.; Kanselaar, G.

    2009-01-01

    This study investigated the effects of group member familiarity during computer-supported collaborative learning. Familiarity may have an impact on online collaboration, because it may help group members to progress more quickly through the stages of group development, and may lead to higher group

  7. Role Perception among Faculty Members at Teacher Education Colleges

    Science.gov (United States)

    Grobgeld, Esther; Teichman-Weinberg, Ariela; Wasserman, Egoza; Barchilon Ben-Av, Mercedes

    2016-01-01

    The goal of this study was to examine how faculty members at academic colleges of education perceive their role and to consider elements of their work that need to be included in a professional profile definition. All faculty of one college of education were asked: "What are the tasks/obligations of a faculty member at a college of education?…

  8. Members of the Committee | Women in Science | Initiatives | Indian ...

    Indian Academy of Sciences (India)

    Members of the Committee. Rohini M Godbole; Rajinder J Hans-Gill; D. Balasubramanian. Charge of the Committee. The members of the committee were assigned to formulate the terms of reference and to define appropriate action points to be followed for its work. The committee had come up with many initiatives and ...

  9. Leading Teams of Leaders: What Helps Team Member Learning?

    Science.gov (United States)

    Higgins, Monica; Young, Lissa; Weiner, Jennie; Wlodarczyk, Steven

    2010-01-01

    School districts are moving toward a new form of management in which superintendents need to form and nurture leadership teams. A study of 25 such teams in Connecticut suggests that a team's effectiveness is maximized when the team members are coached by other team members, not the superintendent, and when they are coached on task-related…

  10. 32 CFR 884.17 - Commander's instruction letter to member.

    Science.gov (United States)

    2010-07-01

    ... instruction letter to member. Subject: Instructions in Case of Release on Bail or Personal Recognizance 1. You... 32 National Defense 6 2010-07-01 2010-07-01 false Commander's instruction letter to member. 884.17... civilian custody on bail or on your own recognizance, report immediately in person or by telephone to the...

  11. 22 CFR 19.10 - Types of annuities to members.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Types of annuities to members. 19.10 Section 19.10 Foreign Relations DEPARTMENT OF STATE PERSONNEL BENEFITS FOR SPOUSES AND FORMER SPOUSES OF PARTICIPANTS IN THE FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.10 Types of annuities to members. ...

  12. Education of ethics committee members: experiences from Croatia.

    NARCIS (Netherlands)

    Borovecki, A.; Have, H.A.M.J. ten; Oreskovic, S.

    2006-01-01

    OBJECTIVES: To study knowledge and attitudes of hospital ethics committee members at the first workshop for ethics committees in Croatia. DESIGN: Before/after cross-sectional study using a self administered questionnaire. SETTING: Educational workshop for members of hospital ethics committees,

  13. Cooperative CEO Identity and Efficient Governance: Member or Outside CEO?

    NARCIS (Netherlands)

    Q.X. Liang (Qiao Xin); G.W.J. Hendrikse (George)

    2012-01-01

    textabstractA principal-agent model is formulated to capture the efficiency of cooperatives with a member CEO and cooperatives with an employed outsider as CEO. Results of the model show that the incentive strength regarding the member CEO is stronger compared to that of the outside CEO in order to

  14. Teaching Styles and Occupational Stress among Chinese University Faculty Members

    Science.gov (United States)

    Zhang, Li-fang

    2007-01-01

    The primary aim of this research is to investigate the predictive power of occupational stress for teaching style among university faculty members. A sample of 144 faculty members from a large university in the People's Republic of China rated themselves on three ability scales and responded to the Thinking Styles in Teaching Inventory and to four…

  15. 78 FR 52995 - Senior Executive Service: Performance Review Board Members

    Science.gov (United States)

    2013-08-27

    ... SMALL BUSINESS ADMINISTRATION Senior Executive Service: Performance Review Board Members AGENCY: U. S. Small Business Administration. ACTION: Notice of Members for the FY 2014 Performance Review Board. SUMMARY: Title 5 U.S.C. 4314(c)(4) requires each agency to publish notification of the appointment of...

  16. 76 FR 64421 - Senior Executive Service: Performance Review Board Members

    Science.gov (United States)

    2011-10-18

    ... SMALL BUSINESS ADMINISTRATION Senior Executive Service: Performance Review Board Members AGENCY: U.S. Small Business Administration. ACTION: Notice of Members for the FY 2011 Performance Review Board. SUMMARY: Title 5 U.S.C. 4314(c)(4) requires each agency to publish notification of the appointment of...

  17. 77 FR 70204 - Senior Executive Service: Performance Review Board Members

    Science.gov (United States)

    2012-11-23

    ... SMALL BUSINESS ADMINISTRATION Senior Executive Service: Performance Review Board Members AGENCY: U.S. Small Business Administration. ACTION: Notice of Members for the FY 2012 Performance Review Board. SUMMARY: Title 5 U.S.C. 4314(c)(4) requires each agency to publish notification of the appointment of...

  18. 75 FR 71785 - Senior Executive Service: Performance Review Board Members

    Science.gov (United States)

    2010-11-24

    ... SMALL BUSINESS ADMINISTRATION Senior Executive Service: Performance Review Board Members AGENCY: U.S. Small Business Administration. ACTION: Notice of Members for the FY 2010 Performance Review Board. SUMMARY: Title 5 U.S.C. 4314(c)(4) requires each agency to publish notification of the appointment of...

  19. Effect of corrosion on the buckling capacity of tubular members

    Science.gov (United States)

    Øyasæter, F. H.; Aeran, A.; Siriwardane, S. C.; Mikkelsen, O.

    2017-12-01

    Offshore installations are subjected to harsh marine environment and often have damages from corrosion. Several experimental and numerical studies were performed in the past to estimate buckling capacity of corroded tubular members. However, these studies were either based on limited experimental tests or numerical analyses of few cases resulting in semi-empirical relations. Also, there are no guidelines and recommendations in the currently available design standards. To fulfil this research gap, a new formula is proposed to estimate the residual strength of tubular members considering corrosion and initial geometrical imperfections. The proposed formula is verified with results from finite element analyses performed on several members and for varying corrosion patch parameters. The members are selected to represent the most relevant Eurocode buckling curve for tubular members. It is concluded that corrosion reduces the buckling capacity significantly and the proposed formula can be easily applied by practicing engineers without performing detailed numerical analyses.

  20. CE: Military Sexual Trauma in Male Service Members.

    Science.gov (United States)

    Eckerlin, Denise M; Kovalesky, Andrea; Jakupcak, Matthew

    2016-09-01

    : The experience of military sexual trauma (MST), which can result from assault, battery, or harassment of a sexual nature, may jeopardize the mental health of service members as well as that of their family members, colleagues, and community members. Although a greater proportion of female than male service members are subjected to MST, the Department of Defense estimates that the absolute numbers of affected men and women, across all ranks and branches of military service, are nearly equal because roughly 85% of military members are men. Little research has explored the effects of MST on men. This article discusses the unique ways in which men may experience MST, and examines how social stereotypes of masculinity, myths surrounding sexual assault, and military culture and structure often influence a man's interpretation of an attack and his likelihood of reporting the incident or seeking treatment. It describes current treatments for MST-related mental health conditions and addresses implications for nurses and other health care professionals.

  1. The Foreign Policies of European Union Member States

    DEFF Research Database (Denmark)

    Foreign Policies of EU Member States provides a clear and current overview of the motivations and outcomes of EU Member States regarding their foreign policy-making within and beyond the EU. It provides an in-depth analysis of intra-EU policy-making and sheds light, in an innovative and understan......Foreign Policies of EU Member States provides a clear and current overview of the motivations and outcomes of EU Member States regarding their foreign policy-making within and beyond the EU. It provides an in-depth analysis of intra-EU policy-making and sheds light, in an innovative...... prerogative exercised by all EU Member States is to construct their own foreign policies on everything from trade and defence with the rest of the world. This combination of clarity, thematic structure and empirical case studies make this an ideal textbook for all upper-level students of European foreign...

  2. Ongoing and planned fuel safety research in NEA member states - Compiled from SEGFSM Members' Contributions

    International Nuclear Information System (INIS)

    2002-10-01

    This report is in response to an action placed on SEGFSM members to compile ongoing and planned fuel safety research in NEA member states with the aim of providing CSNI an overview on related R and D international programmes and projects, along with the identification of current and future needs and priorities. A questionnaire was distributed to SEGFSM members on 18 October 2000, requesting them to identify fuel safety research programmes and to provide information on achievements and future plans. The questionnaire required respondents to provide information on the ongoing R and D programmes under the following headings: Title; Research Laboratory/Sponsor(s); Objectives/Goals; Status of Work; Brief description/presentation of the main results achieved; Future plans; References. Replies were received from organizations in the following countries: Belgium, Canada, Czech Republic, France, Germany, Hungary, Japan, Korea, Norway (Halden Reactor Project), Sweden, Switzerland, United Kingdom, USA. The report is based on the information provided in the replies received, as a consequence it cannot be viewed as comprehensive; programmes may well be in progress in addition to those detailed here. It is also possible that the detailed results of some programmes may remain proprietary and therefore not available in the short term. The report is organized in topic sections relating to: fuel and clad studies, integral fuel rod tests and PIE, LOCA and RIA studies including whole rods and bundles as well as single effects studies of fuel and cladding, code development for both steady state and transient fuel behaviour, thermal hydraulics, reactor physics codes and finally severe accident studies. The main issues for the current generation of reactors are those of high burn-up performance in normal operations, LOCA and RIA conditions and the main goal for the industry is to consolidate the safety issues to bring all countries up to a licensed discharge burn-up of ∼60 MWd/kg in

  3. Synergistic effect of polymorphisms of paraoxonase gene cluster and arsenic exposure on electrocardiogram abnormality

    International Nuclear Information System (INIS)

    Liao, Y.-T.; Li, W.-F.; Chen, C.-J.; Prineas, Ronald J.; Chen, Wei J.; Zhang Zhuming; Sun, C.-W.; Wang, S.-L.

    2009-01-01

    Arsenic has been linked to increased prevalence of cancer and cardiovascular disease (CVD), but the long-term impact of arsenic exposure remains unclear. Human paraoxonase (PON1) is a high-density lipoprotein-associated antioxidant enzyme which hydrolyzes oxidized lipids and is thought to be protective against atherosclerosis, but evidence remains limited to case-control studies. Only recently have genes encoding enzymes responsible for arsenic metabolism, such as AS3MT and GSTO, been cloned and characterized. This study was designed to evaluate the synergistic interaction of genetic factors and arsenic exposure on electrocardiogram abnormality. A total of 216 residents from three tap water implemented villages of previous arseniasis-hyperendemic regions in Taiwan were prospectively followed for an average of 8 years. For each resident, a 12-lead conventional electrocardiogram (ECG) was recorded and coded by Minnesota Code standard criteria. Eight functional polymorphisms of PON1, PON2, AS3MT, GSTO1, and GSTO2 were examined for genetic susceptibility to ECG abnormality. Among 42 incident cases with ECG deterioration identified among 121 baseline-normal subjects, arsenic exposure was significantly correlated with incidence of ECG abnormality. In addition, polymorphisms in two paraoxonase genes were also found associated with the incidence of ECG abnormality. A haplotype R-C-S constituted by polymorphisms of PON1 Q192R, -108C/T and PON2 C311S was linked to the increased risk. Subjects exposed to high levels of As (cumulative As exposure > 14.7 ppm-year or drinking artesian well water > 21 years) and carrying the R-C-S haplotype had significantly increased risks for ECG abnormality over those with only one risk factor. Results of this study showed a long-term arsenic effect on ECG abnormality and significant gene-gene and gene-environment interactions linked to the incidence of CVD. This finding might have important implications for a novel and potentially useful

  4. 19 CFR 122.49b - Electronic manifest requirement for crew members and non-crew members onboard commercial aircraft...

    Science.gov (United States)

    2010-04-01

    ...” means air carrier employees and their family members and persons traveling onboard a commercial aircraft...), air carrier employees, their family members, and persons onboard for the safety of the flight are...) Date of birth; (iii) Place of birth (city, state—if applicable, country); (iv) Gender (F = female; M...

  5. Method for brazing together planar and nonplanar metal members

    International Nuclear Information System (INIS)

    Hammersand, F.G.; Witkowski, A.J.

    1985-01-01

    The invention relates to a method and apparatus for brazing two metal members together, at least one of which is nonplanar, in a brazing furnace using a substantially pure brazing material. The method comprises the steps of utilizing a brazing fixture to hold the two metal members in tangential relation to one another along a portion of each member so that a cavity is formed adjacent to the contacting portions. A braze material is then positioned within the cavity. The braze fixture, the metal members, and the braze material are then placed in a brazing furnace. A heat shield is then placed over the braze fixture, the metal members, and the braze material to shield the braze material from direct furnace radiation. The furnace temperature is linearly increased at a rate of about 180 0 C. per hour until a temperature of 350 0 C. is achieved. Heat is transferred by conduction from the metal members to the braze material to cause the braze material to melt. Some material from the metal members slowly diffuses into the braze material forming a braze joint. The furnace is rapidly cooled to room temperature using nitrogen gas. The brazed assemblies made according to this method are superior to assemblies formed by heliarc welding

  6. Nuclear fuel assembly incorporating primary and secondary structural support members

    International Nuclear Information System (INIS)

    Carlson, W.R.; Gjertsen, R.K.; Miller, J.V.

    1987-01-01

    A nuclear fuel assembly, comprising: (a) an upper end structure; (b) a lower end structure; (c) elongated primary structural members extending longitudinally between and rigidly interconnecting the upper and lower end structures, the upper and lower end structures and primary structural members together forming a rigid structural skeleton of the fuel assembly; (d) transverse grids supported on the primary structural members at axially spaced locations therealong between the upper and lower end structures; (e) fuel rods extending through and supported by the grids between the upper and lower end structures so as to extend in generally side-by-side spaced relation to one another and to the primary structural members; and (f) elongated secondary structural members extending longitudinally between but unconnected with the upper and lower end structures, the secondary structural members extending through and rigidly interconnected with the grids to extend in generally side-by-side spaced relation to one another, to the fuel rods and to the primary structural members so as to bolster the stiffness of the structural skeleton of the fuel assembly

  7. Development of magnetostrictive active members for control of space structures

    Science.gov (United States)

    Johnson, Bruce G.; Avakian, Kevin M.; Fenn, Ralph C.; Gaffney, Monique S.; Gerver, Michael J.; Hawkey, Timothy J.; Boudreau, Donald J.

    1992-08-01

    The goal of this Phase 2 Small Business Innovative Research (SBIR) project was to determine the technical feasibility of developing magnetostrictive active members for use as truss elements in space structures. Active members control elastic vibrations of truss-based space structures and integrate the functions of truss structure element, actively controlled actuator, and sensor. The active members must control structural motion to the sub-micron level and, for many proposed space applications, work at cryogenic temperatures. Under this program both room temperature and cryogenic temperature magnetostrictive active members were designed, fabricated, and tested. The results of these performance tests indicated that room temperature magnetostrictive actuators feature higher strain, stiffness, and force capability with lower amplifier requirements than similarly sized piezoelectric or electrostrictive active members, at the cost of higher mass. Two different cryogenic temperature magnetostrictive materials were tested at liquid nitrogen temperatures, both with larger strain capability than the room temperature magnetostrictive materials. The cryogenic active member development included the design and fabrication of a cryostat that allows operation of the cryogenic active member in a space structure testbed.

  8. TO ALL MEMBERS OF THE PERSONNEL: Summer work for children of members of the personnel

    CERN Multimedia

    2013-01-01

    During the period from 17 June to 13 September 2013 inclusive, a limited number of jobs for summer work at CERN (normally unskilled work of a routine nature) will be available to children of members of the personnel (i.e. anyone holding an employment or association contract with the Organization). Candidates must be aged between 18 and 24 inclusive on the first day of the contract, and must have insurance coverage for both illness and accident. The duration of all contracts will be 4 weeks and the allowance will be CHF 1500.- for the whole period.  Candidates should apply via HR Department’s electronic recruitment system: https://ert.cern.ch/browse_www/wd_portal.show_job?p_web_site_id=1&p_web_page_id=10691 Completed application forms must be returned by 12 April 2013 at the latest. The results of the selection will be available by the end of May 2013. For further information, please contact: Virginie.Galvin@cern.ch - Tel. 72855 (Geraldine.Ballet@cern.ch - Tel. 74151) HR Departm...

  9. To all members of the personnel: Summer work for children of members of the personnel

    CERN Multimedia

    2014-01-01

    During the period from 16 June to 12 September 2014 inclusive, a limited number of jobs for summer work at CERN (normally unskilled work of a routine nature) will be made available to children of members of the personnel (i.e. anyone holding an employment or association contract with the Organization).   Candidates must be aged between 18 and 24 inclusive on the first day of the contract, and must have insurance coverage for both illness and accident. The duration of all contracts will be 4 weeks and the allowance will be CHF 1500.- for this period. Candidates should apply via the HR Department’s electronic recruitment system (http://ert.cern.ch ): http://jobs.web.cern.ch/job/10996. Completed application forms must be returned by 6 April 2014 at the latest. The results of the selection will be available by the end of May 2014. For further information, please contact: Virginie.Galvin@cern.ch, Tel.: 72855 (or Geraldine.Ballet@cern.ch, Tel.: 74151).  HR Department

  10. One member, two leaders: extending leader-member exchange theory to a dual leadership context.

    Science.gov (United States)

    Vidyarthi, Prajya R; Erdogan, Berrin; Anand, Smriti; Liden, Robert C; Chaudhry, Anjali

    2014-05-01

    In this study, we develop and test a model that extends leader-member exchange (LMX) theory to a dual leadership context. Drawing upon relative deprivation theory, we assert that when employees work for 2 leaders, each relationship exists within the context of the other relationship. Thus, the level of alignment or misalignment between the 2 relationships has implications for employees' job satisfaction and voluntary turnover. Employing polynomial regression on time-lagged data gathered from 159 information technology consultants nested in 26 client projects, we found that employee outcomes are affected by the quality of the relationship with both agency and client leaders, such that the degree of alignment between the 2 LMXs explained variance in outcomes beyond that explained by both LMXs. Results also revealed that a lack of alignment in the 2 LMXs led to asymmetric effects on outcomes, such that the relationship with agency leader mattered more than the relationship with one's client leader. Finally, frequency of communication with the agency leader determined the degree to which agency LMX affected job satisfaction in the low client LMX condition. (c) 2014 APA, all rights reserved.

  11. TO ALL MEMBERS OF THE PERSONNEL Temporary work for children of members of the personnel

    CERN Multimedia

    2001-01-01

    During the period mid-June to mid-September 2001, there will be a limited number of vacancies for temporary work at CERN (normally unskilled work of a routine nature) which will be made available to children of members of the personnel (that is, anyone holding an employment or association contract with CERN). It should be noted that candidates must be aged between 18 and 24 inclusive on the first day of the contract, and that they must have insurance cover for both illness and accident. In view of the limited number of vacancies available, no children previously appointed at CERN under this scheme can be considered. The duration of all appointments will be 4 weeks, the allowance being CHF 1538.- net for this period. Application forms can be obtained via the Web at the following address: http://cern.web.cern.ch/CERN/Divisions/PE/ under the heading 'Other Useful Links' or from Paula Barriere, Personnel Management Group (by using the slip below or by electronic mail to Paula.Barriere@.cern.ch). Completed applic...

  12. Youth Gang Members: Psychiatric Disorders and Substance Use

    Directory of Open Access Journals (Sweden)

    Albert John Sargent

    2013-10-01

    Full Text Available Objective: Approximately 260,000 of youth in the United States are gang-affiliated. There is a paucity of data available to identify the prevalence of mental health disorders in this population. Gang members share many of the features of “at risk” or juvenile justice involved youth who deny gang membership. The authors identified rates of psychiatric disorders within a juvenile justice population delineated in three categories: gang members, friends of gang members, and non-gang members. Methods: A retrospective review of records obtained by a juvenile probation department. A large detention center conducted mental health screenings on 7,615 youth aged 13–17. The mental health screenings were performed by either a master level or doctoral level mental health professional. Odds ratios were computed as an effect size for gender, race/ethnic differences, and gang-membership associations with self-reported psychiatric and substance use disorders. Logistic regression was used to evaluate the risk for psychiatric and substance use disorders among gang-members and friends of gang members. Diagnostic information was generated through a clinical interview and flexible battery. Results: Of the 7,615 youth in this study, ~50% had contact with gangs; 11% were self-identified gang-members, and 38% acknowledged having at least one friendship with a gang member. Similar to other studies, being male was a risk-factor for gang-membership (2.31 odds. In this multi-racial and ethnic study, Latinos had a greater affiliation with gang membership and association with gang members as friends (1.44 odds. Gang members were found to have increased rates of post-traumatic stress disorder (1.77 odds, current substance abuse (2.58 odds, oppositional defiant disorder, (1.24 odds and conduct disorder (4.05 odds; however, they were less likely to have an adjustment disorder than non-gang members (0.70 odds. Conclusions: Juveniles who received a mental health assessment

  13. Members of House Committee on Science and Astronautics Visited MSFC

    Science.gov (United States)

    1962-01-01

    The members of the House Committee on Science and Astronautics visited the Marshall Space Flight Center (MSFC) on March 9, 1962 to gather first-hand information of the nation's space exploration program. The congressional group was composed of members of the Subcommittee on Marned Space Flight. Headed by Representative Olin E. Teague of Texas, other members were James G. Fulton, Pennsylvania; Ken Heckler, West Virginia; R. Walter Riehlman, New York; Richard L. Roudebush,, Indiana; John W. Davis, Georgia; James C. Corman, California; Joseph Waggoner, Louisiana; J. Edgar Chenoweth, Colorado; and William G. Bray, Indiana.

  14. Means to flexibly attach lens frames to temple members

    Science.gov (United States)

    Smith, Harry D.

    1995-01-01

    The invention is a band hinge for flexibly connecting the temple member to the lens frame thereby preventing damage from inadvertent pressure or cyclic wear. A distinguishing feature of the invention is the use of a band hinge that holds together the temple member and the lens frame without the use of a pin or screw hinging mechanism. The invention allows for a high degree of freedom of movement for the temple member with respect to the lens frame which will prevent most forms of damages to the glasses from these types of events.

  15. Positivity bias in judging ingroup members' emotional expressions.

    Science.gov (United States)

    Lazerus, Talya; Ingbretsen, Zachary A; Stolier, Ryan M; Freeman, Jonathan B; Cikara, Mina

    2016-12-01

    We investigated how group membership impacts valence judgments of ingroup and outgroup members' emotional expressions. In Experiment 1, participants, randomized into 2 novel, competitive groups, rated the valence of in- and outgroup members' facial expressions (e.g., fearful, happy, neutral) using a circumplex affect grid. Across all emotions, participants judged ingroup members' expressions as more positive than outgroup members' expressions. In Experiment 2, participants categorized fearful and happy expressions as being either positive or negative using a mouse-tracking paradigm. Participants exhibited the most direct trajectories toward the "positive" label for ingroup happy expressions and an initial attraction toward positive for ingroup expressions of fear, with outgroup emotion trajectories falling in between. Experiment 3 replicated Experiment 2 and demonstrated that the effect could not be accounted for by targets' gaze direction. Overall, people judged ingroup faces as more positive, regardless of emotion, both in deliberate and implicit judgments. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  16. Design of reinforced concrete members based on structural mechanics

    International Nuclear Information System (INIS)

    Diaz, B.E.; Schulz, M.

    1984-01-01

    Up to now the design of reinforced concrete linear members is performed with the help of an inconsistent design theory, which nevertherless is sufficiently safe and simple to be used in the practice. The purpose of this paper is to present a rational reinforced concrete design method which is not too dissimilar to the present design rules, but is capable of defining consistently internal stresses along a reinforced concrete section. The present status of the completed computer procedures allows the analysis of linear reinforced concrete members formed by laminar reinforced concrete plates presenting variable thickness. A practical approach is presented for which the concrete and steel section is constant along the member axis. In this case, the concept of the equivalent section is introduced, which allows a simple analysis of the stress pattern along the member section. (Author) [pt

  17. Balanced Ethics Review: A Guide for Institutional Review Board Members

    Directory of Open Access Journals (Sweden)

    Ames Dhai

    2016-12-01

    Full Text Available The aim of this pocket-book size manual is to assist Institutional Review Board (IRB members and chairs conduct ethics review by balancing the two major morally relevant considerations in health research

  18. The Members of the Agency. List of 15 February 1971

    International Nuclear Information System (INIS)

    1971-01-01

    On 15 February 1971 the Members of the Agency were the 102 States listed. It is to be noted that Cambodia became the Khmer Republic on 9 October 1970 and that Nicaragua withdrew from the Agency on 14 December 1970.

  19. Dying in the Hospital: Perspectives of family members.

    Science.gov (United States)

    Dose, Ann Marie; Carey, Elise C; Rhudy, Lori M; Chiu, Yichen; Frimannsdottir, Katrin; Ottenberg, Abigale L; Koenig, Barbara A

    2015-01-01

    Although most patients express a preference to die at home, many (over 30 percent) still die in hospital. This study's purpose was to explore the experience of hospital death from the perspective of patients' family members. interviews were conducted with family members of patients who had died at hospitals affiliated with a large tertiary referral centre in the United States. Content analysis was used to analyze findings. We interviewed 30 family members by phone. Themes were arranged by time frame: before death, time of death, and after death. Families do not interpret clinical cues leading up to death in the same way healthcare providers do; families need clear and direct explanations from providers. Clinicians should assess patient and family understandings of prognosis and communicate clearly and directly. Family members value being with their loved one at the time of death, and they value spending time with the body after death; this should be facilitated in clinical practice.

  20. New policies help faculty members balance work, rest of life

    OpenAIRE

    Trulove, Susan

    2007-01-01

    Virginia Tech has joined a cadre of leading universities with progressive work/life policies that provide flexibility for faculty members and graduate students to address special family and personal issues without jeopardizing their professional progress.

  1. Motivation, Personal Satisfaction of Team Members and Conformity ...

    African Journals Online (AJOL)

    Motivation, Personal Satisfaction of Team Members and Conformity to Team Norms as Predictors of Team Performance. ... The sample included two thousand and eighty-eight athletes (players of six sports) surveyed through a purposive ...

  2. Panel Members | Women in Science | Initiatives | Indian Academy of ...

    Indian Academy of Sciences (India)

    ... Live Streaming. Home; Initiatives; Women in Science; Panel Members ... Dr Nahid Ali is a Chief Scientist, IDI Division, Indian Institute of Chemical Biology, Kolkata. ... An article published in "The Guardian" on 10 best unsung female scientists.

  3. Coping Strategies of Family Members of Hospitalized Psychiatric Patients

    Directory of Open Access Journals (Sweden)

    Phyllis M. Eaton

    2011-01-01

    Full Text Available This exploratory research paper investigated the coping strategies of families of hospitalized psychiatric patients and identified their positive and negative coping strategies. In this paper, the coping strategies of 45 family members were examined using a descriptive, correlational, mixed method research approach. Guided by the Neuman Systems Model and using the Family Crisis Oriented Personal Evaluation Scales and semistructured interviews, this paper found that these family members used more emotion-focused coping strategies than problem-focused coping strategies. The common coping strategies used by family members were communicating with immediate family, acceptance of their situation, passive appraisal, avoidance, and spirituality. The family members also utilized resources and support systems, such as their immediate families, mental health care professionals, and their churches.

  4. 7 CFR 1210.405 - Public member nominations and selection.

    Science.gov (United States)

    2010-01-01

    ... public member shall have no direct financial interest in the commercial production or marketing of.... Election of nominees shall be on the basis of a simple majority of those present and voting. Such election...

  5. STUDY ON COMMUNICATION TEAM’S MEMBERS ROLES

    Directory of Open Access Journals (Sweden)

    Cristina BORCA

    2014-06-01

    Full Text Available The implementation of the management strategy for increasing the competitiveness of modern organizations is more effective if it is correlated with the organizational communication strategy. Team communication of an organization must be an agile one, its agility depending decisively on the way it was constituted, the assigned role for each team member, the statuses etc. A valuation of all skills and abilities of each member of the communication team is therefore required to harmonize and integrate the team into the overall structure of the company. The objective of the paper is to identify the extent to which the formal role of each team member is the same (almost the same with the role determined by applying the Belbin test. The results of the research are prerequisites for development of measures for individual professional development and integration /reintegration of team members in order to increase agility.

  6. Death at the Worksite: Helping Grieving Family Members

    Science.gov (United States)

    ... Grief at Work Working Through Grief About Us Death at the Worksite: Helping Grieving Family Members By ... fatal heart attacks occur in the workplace. Other deaths — from accidents, for example — can also happen during ...

  7. Actuator assembly including a single axis of rotation locking member

    Science.gov (United States)

    Quitmeyer, James N.; Benson, Dwayne M.; Geck, Kellan P.

    2009-12-08

    An actuator assembly including an actuator housing assembly and a single axis of rotation locking member fixedly attached to a portion of the actuator housing assembly and an external mounting structure. The single axis of rotation locking member restricting rotational movement of the actuator housing assembly about at least one axis. The single axis of rotation locking member is coupled at a first end to the actuator housing assembly about a Y axis and at a 90.degree. angle to an X and Z axis providing rotation of the actuator housing assembly about the Y axis. The single axis of rotation locking member is coupled at a second end to a mounting structure, and more particularly a mounting pin, about an X axis and at a 90.degree. angle to a Y and Z axis providing rotation of the actuator housing assembly about the X axis. The actuator assembly is thereby restricted from rotation about the Z axis.

  8. 439 Motivation, Personal Satisfaction of Team Members and ...

    African Journals Online (AJOL)

    User

    2011-07-21

    Jul 21, 2011 ... thousand and eighty-eight athletes (players of six sports) surveyed through a ... of team members, team success, effective communication, ... Volleyball, Basketball, Hockey and Handball fell into the sample of the study.

  9. An Assessment of the Academic Impact of Shock Society Members.

    Science.gov (United States)

    Milgrom, Daniel P; Koniaris, Leonidas G; Valsangkar, Nakul P; Lad, Neha; Bell, Teresa M; Wojcik, Brandon; Zimmers, Teresa A

    2018-05-01

    Professional society membership enhances career development and productivity by offering opportunities for networking and learning about recent advances in the field. The quality and contribution of such societies can be measured in part through the academic productivity, career status, and funding success rates of their members. Here, using Scopus, NIH RePORTER, and departmental websites, we compare characteristics of the Shock Society membership to those of the top 55 NIH-funded American university and hospital-based departments of surgery. Shock Society members' mean number of publications, citations and H-indices were all significantly higher than those of non-members in surgery departments (P productive group of investigators. For surgery faculty, membership is associated with greater academic productivity and career advancement. While it is difficult to ascribe causation, certainly the Shock Society might positively influence careers for its members.

  10. Mental Wellbeing of Family Members of Autistic Adults.

    Science.gov (United States)

    Herrema, Renske; Garland, Deborah; Osborne, Malcolm; Freeston, Mark; Honey, Emma; Rodgers, Jacqui

    2017-11-01

    Family members are often the primary caregiver for autistic adults and this responsibility may impact on the carer's wellbeing and quality of life. 109 family members of autistic adults completed an online survey assessing their wellbeing relating to their caring role for their autistic relative. Family members who were supporting an autistic relative with co-occurring mental health difficulties and who they reported as unprepared for the future, self-reported higher levels of worry, depression, anxiety and stress, and poorer quality of life. These findings emphasise the importance of support for family members of autistic adults, whether through external services to support their relative or individual mental health support for the carer.

  11. [Food hygiene training of members of corporate public catering committees].

    Science.gov (United States)

    Quaranta, Gianluigi; Laurenti, Patrizia; Gerardo Cairo, Antonio; Ricciardi, Gualtiero

    2007-01-01

    A food hygiene training course was offered to 25 members of the public catering committees of seven corporate restaurants. In order to evaluate the effectiveness of the course and identify critical topics, participants were asked to complete a questionnaire before and after completing the training course. Results are presented in this article and underscore the importance of training members of public catering committees in addition to food handlers.

  12. Improving Acceptance, Integration and Health among LGBT Service Members

    Science.gov (United States)

    2017-10-01

    these stressors on LGBT service members is poorly understood, with very little data available on the unique physical and mental health needs of these...Bullying • Overall health • Healthcare utilization • Lost duty days • Sick call visits • Physical health symptoms • Sexual/gender identity disclosure...Award Numbers: W81XWH-15-1-0699 Title: Improving Acceptance, Integration and Health among LGBT Service Members Principal Investigators: Jeremy

  13. The Members of the Agency: List of 3 October 1990

    International Nuclear Information System (INIS)

    1990-10-01

    This Revision of INFCIRC/2 has been issued to inform the Member States that with effect from 3 October 1990, the German Democratic Republic acceded to the Federal Republic of Germany and the two German states have united to form one sovereign state, which as a single member of the IAEA remains bound by the provisions of the Statute. As from the date of unification, the Federal Republic of Germany will act in the International Atomic Energy Agency under the designation of ''Germany''

  14. Lineup member similarity effects on children's eyewitness identification

    OpenAIRE

    Fitzgerald, Ryan J.; Whiting, Brittany F.; Therrien, Natalie M.; Price, Heather L.

    2014-01-01

    To date, research investigating the similarity among lineup members has focused on adult eyewitnesses. In the present research, children made identifications from lineups containing members of lower or higher similarity to a target person. In Experiment 1, following a live interaction, children's (6–14 years) correct identification rate was reduced in higher-similarity relative to lower-similarity lineups. In Experiment 2, children (6–12 years) and adults watched a video containing a target p...

  15. Improving Acceptance, Integration, and Health Among LGBT Service Members

    Science.gov (United States)

    2016-10-01

    lifting of the bans – remains alive and well, with some LGBT service members experiencing interpersonal and institutional discrimination ...being among LGBT service members and improve unit cohesion. The military has always been a leader in understanding and implementing gender and...matters. These should be people that you know and who know you. These should be people you have had contact with in the past 3 months or so – either in

  16. Improving Acceptance, Integration and Health among LGBT Service Members

    Science.gov (United States)

    2017-10-01

    provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently...phases. In Phase I we (a) convened an expert panel to advise the study and (b) interview a diverse set of military service members (n=42) using a...have convened our expert panel of advisors and have completed 38 interviews with LGBT military service members. 15. SUBJECT TERMS Military, LGBT

  17. Factors affecting members' evaluation of agri-business ventures' effectiveness.

    Science.gov (United States)

    Hashemi, Seyyed Mahmoud; Hedjazi, Yousef

    2011-02-01

    This paper presents work to identify factors affecting effectiveness of agri-business ventures (A-BVs) on the side of providers as perceived by their members. A survey was conducted among 95 members of A-BVs in Zanjan province, Iran. To collect data, a questionnaire was designed. Two distinct groups of A-BVs with low (group 1) and high (group 2) perceived (evaluated) levels of effectiveness were revealed. The study showed that there were significant differences between the two groups on important characteristics of A-BVs and their members. The study also found that there were statistically significant relationships between A-BVs' governance structure and capacity, management and organization characteristics and the perceived effectiveness, whereas there were no statistically significant relationships between A-BVs' advisory methods characteristic applied by members and the perceived effectiveness. Logistic regression results also showed that level of application of rules encouraging members' active participation in important decision makings, clear terms of reference to guide contracting procedures, roles, and responsibilities of parties involved, type of people served and geographical area of program coverage, and members' ability to use Information and Communication Technologies (ICTs) were predictors of the perceived (evaluated) effectiveness of A-BVs. The study showed that evaluation of members of effectiveness of A-BVs would not be the same. It is suggested that Iranian public agricultural extension organization, as responsible organization for monitoring and evaluating services conducted by A-BVs, considered these differences between members with different levels of some important variables. 2010 Elsevier Ltd. All rights reserved.

  18. Education of ethics committee members: experiences from Croatia.

    Science.gov (United States)

    Borovecki, A; ten Have, H; Oresković, S

    2006-03-01

    To study knowledge and attitudes of hospital ethics committee members at the first workshop for ethics committees in Croatia. Before/after cross-sectional study using a self administered questionnaire. Educational workshop for members of hospital ethics committees, Zagreb, 2003. Knowledge and attitudes of participants before and after the workshop; everyday functioning of hospital ethics committees. The majority of the respondents came from committees with at least five members. The majority of ethics committees were appointed by the governing bodies of their hospitals. Most committees were founded after the implementation of the law on health protection in 1997. Membership structure (three physicians and two members from other fields) and functions were established on the basis of that law. Analysis of research protocols was the main part of their work. Other important functions-education, case analysis, guidelines formation-were neglected. Members' level of knowledge was not sufficient for the complicated tasks they were supposed to perform. However, it was significantly higher after the workshop. Most respondents felt their knowledge should be improved by additional education. Their views on certain issues and bioethical dilemmas displayed a high level of paternalism and over protectiveness, which did not change after the workshop. The committees developed according to bureaucratic requirements. Furthermore, there are concerns about members' knowledge levels. More efforts need to be made to use education to improve the quality of the work. Additional research is necessary to explore ethics committees' work in Croatia especially in the hospital setting.

  19. Member Heterogeneity in Agricultural Cooperatives: A Systems-Theoretic Perspective

    Directory of Open Access Journals (Sweden)

    Constantine Iliopoulos

    2018-04-01

    Full Text Available All over the globe, cooperatives are plagued by pervasive member heterogeneity problems that are induced by the radical and dynamic changes in the business environment. Most current solutions to these problems emphasize strengthening member loyalty and commitment. Yet, many of these solutions are symptomatic rather than fundamental. Searching for fundamental solutions, this paper draws on the Luhmannian system-environment paradigm. Bringing this paradigm to bear on the cooperative scholarship, the paper views cooperatives as operationally closed systems maintaining a precarious relationship to their outer environment, which includes cooperative members. In view of their operational closure, cooperatives tend to overstrain the carrying capacity of their environment by being active in the areas marked by a limited extent of the true commonness of member interests. This overstraining results in a host of problems associated with member heterogeneity. The fundamental solutions following from the system-environment paradigm require the adjustment of cooperative boundaries and goals in light of the evolving range of the true common interests of members. In terms of methodology, we review the extant literature, synthesize the main elements of the system-environment approach and conduct a meta-analysis of case studies and other empirical research to highlight our theoretical arguments.

  20. Understanding type 2 diabetes: including the family member's perspective.

    LENUS (Irish Health Repository)

    White, Patricia

    2012-02-01

    PURPOSE: The purpose of this study was to examine the relationship between psychological and social factors and diabetes outcomes in people with type 2 diabetes and their family members. METHODS: A total of 153 patients with type 2 diabetes were assessed at a diabetes outpatient clinic and postal questionnaires were sent to nominated family members. The measures examined were diabetes knowledge, social support, well-being, and illness perceptions. RESULTS: When compared with those with diabetes, family members reported lower positive well-being and lower levels of satisfaction with support. They also perceived diabetes as a more cyclical illness, which was controlled more by treatment than by the individual. Family members also reported that the person with diabetes was more emotionally distressed and knew more about diabetes than the patient had actually reported himself or herself. There were no differences between the family members of those in good or poor glycaemic control. CONCLUSIONS: This study reinforces the importance of understanding social context and illness beliefs in diabetes management. It also highlights the potential for including family members in discussions and education about diabetes management.

  1. Computer Programme Library at Ispra: Service to IAEA Member States

    International Nuclear Information System (INIS)

    1974-01-01

    In 1964, in view of the increasingly important role of computers in atomic energy, the Nuclear Energy Agency of the Organization for Economic Co-operation and Development established a Computer Programme Library (CPL) at Ispra, Italy. The original purpose of this Library, then consisting chiefly of programmes for reactor calculations, was to improve communication between the originators of the computer programmes and the scientists and engineers in Member States of the OECD who used them, thus furthering the efficient and economic use of the many large and expensive computers in the countries concerned. During the first few years of the Library's operation, a growing interest in its activities became evident in countries which were not members of the OECD. The Director General of the International Atomic Energy Agency, aware that such countries which were Member States of the IAEA could benefit from the Library's services, concluded an agreement with the Nuclear Energy Agency in 1967 to the effect that these services would be extended to all IAEA Member States. In March 1968, the Director General announced by circular letter that these services were available, and requested the governments of Member States that were not members of OECD to nominate establishments to participate in the activities of the Computer Programme Library. By August 1973, 32 such establishments were regularly using the services of the CPL

  2. Staff members' perceptions of an animal-assisted activity.

    Science.gov (United States)

    Bibbo, Jessica

    2013-07-01

    To examine the perceptions of staff members toward the implementation of an animal-assisted activity (AAA) in an outpatient regional cancer center. Quasi-experimental, post-test design. An adult outpatient regional cancer center in northern California. 34 facility staff members. Self-report questionnaire following four weeks of AAA visitation. Visits took place three times a week for a total of 12 visits. Perceptions of the AAA. Previous perceptions toward AAA influenced the perceptions of the visitation's efficacy. Direct and indirect interaction with the visiting AAA teams was positively associated with perceptions of the AAA. A disagreement occurred that the AAA had caused extra stress or work for staff. Enjoyment of interacting with the dog handler was not significantly different from interacting with the dog; however, it was more positively correlated to acceptance of the AAA. The study provided evidence that the AAA was generally accepted by staff members. Individual staff members' perceptions of dogs and AAAs can influence their receptivity to AAA interventions. Interaction with AAA teams should be voluntary and available for patients and staff members. AAA may be introduced into facilities without creating the perception of extra stress or work for staff members. Providing staff the opportunity to interact with visiting AAA teams may be beneficial for the success of such programs. The human handler in AAA teams may play a vital role in the staff acceptance of such programs.

  3. Technical nursing students interacting with family members of hospitalized children

    Directory of Open Access Journals (Sweden)

    Juliana Yukari Takahashi Onishi

    Full Text Available ABSTRACT Objective: To understand technical nursing students' meaning of interacting with family members of hospitalized children. Method: Symbolic Interactionism was used as the theoretical framework and Qualitative Content Analysis was the methodological procedure. A total of eight graduates from an institution situated in the city of Osasco, Sao Paulo state, participated in this study. Data were collected through semi-structured interviews. Results: A total of five representative themes were revealed: Dealing with difficult situations with family members; Perceiving oneself to be unprepared to interact with family members; Family members being a helpful tool; Developing strategies to obtain a good interaction with family members; and Teachers being facilitators of the interaction with family members. Final considerations: To be acquainted with this experience has led to the understanding of the need to include the theme of family care in the curriculum of the Technical Nursing Course. Additionally, the present study contributed to reflections on the importance of such knowledge for this population and to the development of future studies, as this theme has been scarcely explored in the literature.

  4. THE COOLEST ISOLATED BROWN DWARF CANDIDATE MEMBER OF TWA

    Energy Technology Data Exchange (ETDEWEB)

    Gagné, Jonathan; Lafrenière, David; Doyon, René; Malo, Lison; Artigau, Étienne [Département de Physique and Observatoire du Mont-Mégantic, Université de Montréal, C.P. 6128 Succ. Centre-ville, Montréal, Qc H3C 3J7 (Canada); Faherty, Jacqueline K. [Department of Terrestrial Magnetism, Carnegie Institution of Washington, Washington, DC 20015 (United States); Cruz, Kelle, E-mail: jonathan.gagne@astro.umontreal.ca, E-mail: jfaherty17@gmail.com [Department of Astrophysics, American Museum of Natural History, Central Park West at 79th Street, New York, NY 10034 (United States)

    2014-04-10

    We present two new late-type brown dwarf candidate members of the TW Hydrae association (TWA): 2MASS J12074836-3900043 and 2MASS J12474428-3816464, which were found as part of the BANYAN all-sky survey (BASS) for brown dwarf members of nearby young associations. We obtained near-infrared (NIR) spectroscopy for both objects (NIR spectral types are respectively L1 and M9), as well as optical spectroscopy for J1207-3900 (optical spectral type is L0γ), and show that both display clear signs of low gravity, and thus youth. We use the BANYAN II Bayesian inference tool to show that both objects are candidate members to TWA with a very low probability of being field contaminants, although the kinematics of J1247-3816 seem slightly at odds with that of other TWA members. J1207-3900 is currently the latest-type and the only isolated L-type candidate member of TWA. Measuring the distance and radial velocity of both objects is still required to claim them as bona fide members. Such late-type objects are predicted to have masses down to 11-15 M {sub Jup} at the age of TWA, which makes them compelling targets to study atmospheric properties in a regime similar to that of currently known imaged extrasolar planets.

  5. Technical nursing students interacting with family members of hospitalized children.

    Science.gov (United States)

    Onishi, Juliana Yukari Takahashi; Ribeiro, Circéa Amália; Silva, Maria Cristina Ferreira Carlos Rodrigues da; Borba, Regina Issuzu Hirooka de

    2017-01-01

    To understand technical nursing students' meaning of interacting with family members of hospitalized children. Symbolic Interactionism was used as the theoretical framework and Qualitative Content Analysis was the methodological procedure. A total of eight graduates from an institution situated in the city of Osasco, Sao Paulo state, participated in this study. Data were collected through semi-structured interviews. A total of five representative themes were revealed: Dealing with difficult situations with family members; Perceiving oneself to be unprepared to interact with family members; Family members being a helpful tool; Developing strategies to obtain a good interaction with family members; and Teachers being facilitators of the interaction with family members. To be acquainted with this experience has led to the understanding of the need to include the theme of family care in the curriculum of the Technical Nursing Course. Additionally, the present study contributed to reflections on the importance of such knowledge for this population and to the development of future studies, as this theme has been scarcely explored in the literature.

  6. Assessing Protection Against OP Pesticides and Nerve Agents Provided by Wild-Type HuPON1 Purified from Trichoplusia ni Larvae or Induced via Adenoviral Infection

    Science.gov (United States)

    2013-01-01

    by tracking the production of p-nitrophenol (at A412) from paraoxon (9 mM in 50 mM Tris, 10 mM CaCl2, pH 7.4), as previously described [24]. To...poisoning ( salivation and convulsive chewing) that resolved within 1 h of OP exposure, while the remaining animal died between 8 and 16 h after

  7. Interaction between prenatal pesticide exposure and a common polymorphism in the PON1 gene on DNA methylation in genes associated with cardio-metabolic disease risk

    DEFF Research Database (Denmark)

    Declerck, Ken; Remy, Sylvie; Wohlfahrt-Veje, Christine

    2017-01-01

    , mTOR signaling, and type II diabetes mellitus signaling. Furthermore, we were able to identify possible candidate genes which mediated the associations between pesticide exposure and increased leptin level, body fat percentage, and difference in BMI Z score between birth and school age. Conclusions...

  8. Model Agreements for the granting of Associate Member Status Implementation arrangements concerning eligibility for personnel appointments and industrial participation for Associate Member States Progress report by the Management

    CERN Document Server

    2011-01-01

    Model Agreements for the granting of Associate Member Status Implementation arrangements concerning eligibility for personnel appointments and industrial participation for Associate Member States Progress report by the Management

  9. Thermomechanical responses of concrete members strengthened with cfrp sheets

    Science.gov (United States)

    Alqurashi, Abdulaziz

    Strengthening structural members means to be able to carry additional loads. Since, 1990s, a lot of materials and techniques have been established to not only increasing the capacity of member but also facing deterioration. Deterioration has become one of the worst highly maintenance cost. According to The ASCE, 27.1% of all bridges in the United States are not effectual. This is because the high traffic reflects negatively to structural members and cause deterioration of these members. This problem has been cost a lot of money. In addition, FRP has approved that it can increase the capacity of member and overcome some disadvantages such as deterioration. Therefore, CFRP sheet has become widely used. However, high temperatures affect the performance of externally bonded CFRP sheet negatively. Investigation should be carried out on relaxation and flexural performance of members under different temperatures. Therefore, this thesis focus on analyzing and investigating the performance of strengthened members exposed to elevated temperatures (25 to 175 °C). The experimental program was divided to two main parts. First, 144 strengthen concrete blocks 100mm X 150mm X 75mm has been exposed to elevated temperatures. These blocks have two main categories, which are different CFRP sheet width, and different CFRP sheet length. Different CFRP width has three types, which are type 0.25B (25mm x 100mm), type 0.5B (50mm x 100mm) and type 0.75B (75mm x 100mm). Also, Different CFRP length has three types, which are type L e (bonded area of 50 mm by 90mm), 1.25 Le (area of 50mm by 125mm) and type 1.5Le (50mm by 137 mm). Second, studying the performance of RC beams exposed to elevated temperatures.

  10. Stratigraphy, artefact industries and hominid associations for Sterkfontein, member 5.

    Science.gov (United States)

    Kuman, K; Clarke, R J

    2000-06-01

    A revised stratigraphy for the early hominid site of Sterkfontein (Gauteng Province, South Africa) reveals a complex distribution of infills in the main excavation area between 2.8 and 1.4 m.y.a, as well as deposits dating to the mid to late Pleistocene. New research now shows that the Member 4 australopithecine breccia (2.8-2.6 Ma) extends further west than was previously thought, while a late phase of Member 4 is recognized in a southern area. The artefact-bearing breccias were defined sedimentologically as Member 5, but one supposed part of these younger breccias, the StW 53 infill, lacks in situ stone tools, although it does appear to post-date 2.6 Ma when artefacts first appear in the archaeological record. The StW 53 hominid, previously referred to Homo habilis, is here argued to be Australopithecus. The first artefact-bearing breccia of Member 5 is the Oldowan Infill, estimated at 2-1.7 Ma. It occupies a restricted distribution in Member 5 east and contains an expedient, flake-based tool industry associated with a few fossils of Paranthropos robustus. An enlarged cave opening subsequently admitted one or more Early Acheulean infills associated in Member 5 west with Homo ergaster. The artefacts attest to a larger site accumulation between ca. 1.7 and 1.4 Ma, with more intensive use of quartzite over quartz and a subtle but important shift to large flakes and heavier-duty tools. The available information on palaeoenvironments is summarized, showing an overall change from tropical to sub-tropical gallery forest, forest fringe and woodland conditions in Member 4 to more open woodland and grassland habitats in the later units, but with suggestions of a wet localized topography in the Paranthropus -bearing Oldowan Infill. Copyright 2000 Academic Press.

  11. Confirming the least massive members of the Pleiades star cluster

    Science.gov (United States)

    Zapatero Osorio, M. R.; Béjar, V. J. S.; Lodieu, N.; Manjavacas, E.

    2018-03-01

    We present optical photometry (i and Z band) and low-resolution spectroscopy (640-1015 nm) of very faint candidate members (J = 20.2-21.2 mag) of the Pleiades star cluster (120 Myr). The main goal is to address their cluster membership via photometric, astrometric, and spectroscopic studies, and to determine the properties of the least massive population of the cluster through the comparison of the data with younger and older spectral counterparts and state-of-the art model atmospheres. We confirm three bona fide Pleiades members that have extremely red optical and infrared colours, effective temperatures of ≈1150 and ≈1350 K, and masses in the interval 11-20 MJup, and one additional likely member that shares the same motion as the cluster but does not appear to be as red as the other members with similar brightness. This latter object requires further near-infrared spectroscopy to fully address its membership in the Pleiades. The optical spectra of two bona fide members were classified as L6-L7 and show features of K I, a tentative detection of Cs I, hydrides, and water vapour with an intensity similar to high-gravity dwarfs of related classification despite their young age. The properties of the Pleiades L6-L7 members clearly indicate that very red colours of L dwarfs are not a direct evidence of ages younger than ≈100 Myr. We also report on the determination of the bolometric corrections for the coolest Pleiades members. These data can be used to interpret the observations of the atmospheres of exoplanets orbiting stars.

  12. Registered Nurses working together with family members of older people.

    Science.gov (United States)

    Weman, Karin; Fagerberg, Ingegerd

    2006-03-01

    The aim of the study was to reach a more profound understanding, through looking at nurses' working situation, of those factors that influence how nurses are able to work together with family members of older people living in nursing homes or similar facilities. Working with the care of older people as a Registered Nurse provides a varied job with many challenges. Nurses have to co-operate with family members of those in community health care. Co-operation is important and necessary for all involved. Nurses working in elder care in a geographically defined area received a questionnaire with three open-ended questions, on the difficulties and/or problems involved with working together with family members, and the positive or negative aspects of this co-operation. Analysis was carried out using the latent content analysis method. Three themes, problems within the system, interaction with families and caring in nursing work, are presented with categories and their subcategories. The nurses wanted their superior to be a nurse so that their working situation would be better understood. Appreciation from their superior and family members was also a very important part of their work as nurses in community health care. The frequent changes and the lack of time in the work of elder care often put nurses under considerable psychological pressure. For the most part family members are a resource for the elder, but sometimes they will avoid contact, which will make co-operating difficult. Registered Nurses and family members are dependent on each other in their care of the elder. Relevance to clinical practice. More attention should be paid to the working situation of Registered Nurses in community health care, and their ability to work together with family members of older people.

  13. Damage Model of Reinforced Concrete Members under Cyclic Loading

    Science.gov (United States)

    Wei, Bo Chen; Zhang, Jing Shu; Zhang, Yin Hua; Zhou, Jia Lai

    2018-06-01

    Based on the Kumar damage model, a new damage model for reinforced concrete members is established in this paper. According to the damage characteristics of reinforced concrete members subjected to cyclic loading, four judgment conditions for determining the rationality of damage models are put forward. An ideal damage index (D) is supposed to vary within a scale of zero (no damage) to one (collapse). D should be a monotone increasing function which tends to increase in the case of the same displacement amplitude. As for members under large displacement amplitude loading, the growth rate of D should be greater than that of D under small amplitude displacement loading. Subsequently, the Park-Ang damage model, the Niu-Ren damage model, the Lu-Wang damage model and the proposed damage model are analyzed for 30 experimental reinforced concrete members, including slabs, walls, beams and columns. The results show that current damage models do not fully matches the reasonable judgment conditions, but the proposed damage model does. Therefore, a conclusion can be drawn that the proposed damage model can be used for evaluating and predicting damage performance of RC members under cyclic loading.

  14. Building and Benefiting from Member State Laboratory Capacities

    International Nuclear Information System (INIS)

    2014-01-01

    The Department of Nuclear Sciences and Applications implement a number of activities that are designed to enhance and capitalize upon the capacities of Member States’ laboratories worldwide. The Nuclear Sciences and Applications (NA) laboratories strengthen Member States’ analytical capacities through activities such as proficiency tests and inter-laboratory comparisons, and share the capacities of Member States’ laboratories with other Member States through the coordination of relevant networks and participation in the IAEA Collaborating Centre scheme. An example of these activities is the collaborative work carried out by the Terrestrial Environment Laboratory (TEL). The TEL cooperates with the IAEA Environment Laboratories in Monaco to distribute 92 types of reference materials for characterizing radionuclides, stable isotopes, trace elements or organic contaminants. These materials serve as international standards for establishing and evaluating the reliability and accuracy of analytical measurements. This collaborative work between NA laboratories, Member States and laboratories around the globe contribute to the IAEA’s mandate of fostering scientific and technical exchanges for the peaceful use of nuclear science and technology throughout the world

  15. [The role of university hospital executive board members].

    Science.gov (United States)

    Debatin, J F; Rehr, J

    2009-09-01

    Demographic changes and medical progress in combination with vastly altered regulatory and economic environments have forced considerable change in the structure of German university hospitals in recent years. These changes have affected medical care as well as research and medical school training. To allow for more flexibility and a higher level of reactivity to the changing environment German university hospitals were transferred from state agencies to independent corporate structures. All but one remains wholly owned by the respective state governments. The governing structure of these independent medical hospitals consists of an executive board, generally made up of a medical director, a financial director, a director for nursing, and the dean of the medical faculty. In most hospitals, the medical director serves as chief executive officer. The regulations governing the composition and responsibility of the members of the executive board differ from state to state. These differences do affect to some degree the interactive effectiveness of the members of the executive boards. Modalities that stress the overall responsibility for all board members seem to work better than those that define clear portfolio limits. Even more than organizational and regulatory differences, the effectiveness of the work of the executive boards is influenced by the personality of the board members themselves. Success appears to be a clear function of the willingness of all members to work together.

  16. Patient and family members perspectives on radioactive iodine treatment

    Energy Technology Data Exchange (ETDEWEB)

    McGrath, P.; Fitch, M.I. [Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario (Canada)

    1999-08-01

    This report documents the findings of a survey of patients who received radioactive iodine therapy and their family members. The main objective of the survey was to gain an understanding of the experience of receiving radioactive iodine from the patient and family's perspective. The data from this study helped to inform the ARCP and GMA as they developed AC-9 - Principles of the management of radionuclide therapies. A survey was distributed to 700 patients and family members through physicians at 8 sites across Canada. Locations included: Newfoundland, Nova Scotia, Ontario (2 sites), Quebec (2 sites), Manitoba and British Columbia. A total of 190 patients and 140 family members returned completed surveys. Data was analyzed separately for individuals treated as inpatients and those treated as outpatients. The results of the survey provided a perspective from patients and families about their experiences regarding radioactive iodine therapy. The data indicate variation in patients' and family members' perspectives about how precautions are to be implemented. Both patients and family members expressed the desire for more information regarding many aspects of the treatment experience. The results have implications for the development of patient information, continuing education (in particular in the areas of precaution), the provision of access to supportive and counselling services, and the importance of looking at the individual situations of patients and their families. (author)

  17. Board effectiveness: Investigating payment asymmetry between board members and shareholders

    Directory of Open Access Journals (Sweden)

    Wuchun Chi

    2008-01-01

    Full Text Available Board members may well be responsible for dissension between themselves and shareholders since they are simultaneously the setters and receivers of both board remuneration and dividends. They may act out of their own personal interests at the expense of external shareholders. We investigate the impact of ownership structure, board structure and control deviation on payment asymmetry, where excessively high remuneration is paid to board members but considerably lower dividends are distributed to shareholders. We find strong evidence confirming that the smaller the shareholdings of board members and outside blockholders are, the more asymmetric the payments are. With controlling family members on the board and a higher percentage of seats held by independent board members, there is a slight reduction in the likelihood and severity of payment asymmetry. In addition, it is abundantly clear that the larger the board seat-control deviation is, the greater is the likelihood and severity of payment asymmetry. While prior research has primarily focused on board-manager agency issues, the board-shareholder perspective could be even more important in that it is the board that is the most directly delegated agent of shareholders, not the managers

  18. Patient and family members perspectives on radioactive iodine treatment

    International Nuclear Information System (INIS)

    McGrath, P.; Fitch, M.I.

    1999-08-01

    This report documents the findings of a survey of patients who received radioactive iodine therapy and their family members. The main objective of the survey was to gain an understanding of the experience of receiving radioactive iodine from the patient and family's perspective. The data from this study helped to inform the ARCP and GMA as they developed AC-9 - Principles of the management of radionuclide therapies. A survey was distributed to 700 patients and family members through physicians at 8 sites across Canada. Locations included: Newfoundland, Nova Scotia, Ontario (2 sites), Quebec (2 sites), Manitoba and British Columbia. A total of 190 patients and 140 family members returned completed surveys. Data was analyzed separately for individuals treated as inpatients and those treated as outpatients. The results of the survey provided a perspective from patients and families about their experiences regarding radioactive iodine therapy. The data indicate variation in patients' and family members' perspectives about how precautions are to be implemented. Both patients and family members expressed the desire for more information regarding many aspects of the treatment experience. The results have implications for the development of patient information, continuing education (in particular in the areas of precaution), the provision of access to supportive and counselling services, and the importance of looking at the individual situations of patients and their families. (author)

  19. Teenage pregnancy in adolescents with an incarcerated household member.

    Science.gov (United States)

    Whalen, Mathilde Logan; Loper, Ann Booker

    2014-03-01

    This study examines the association between the incarceration of a household member and adolescent pregnancy, and evaluates whether this association extends beyond that of other variables associated with sexual health. We used data from 12 waves of the National Longitudinal Survey of Youth: Child and Young Adult. After eliminating males and individuals who did not respond to key questions, a sample of 1,229 girls (ages 14-19) was analyzed. Girls who experienced the incarceration of a household member faced more demographic and family environment risk factors than those who did not. Regression analyses demonstrated that the addition of a household incarceration variable afforded superior prediction of teenage pregnancy relative to the prediction based on demographic and family features alone. Programs that are directed toward reducing teen pregnancy will benefit from attention to the home situation of the at-risk girl, particularly the experience of household member incarceration and related family dynamics.

  20. Contribution of the Member State Support Programmes to IAEA safeguards

    International Nuclear Information System (INIS)

    Fortakov, V.; Gardiner, D.; Rautjaervi, J.

    1999-01-01

    Over the last twenty years, Member States of the International Atomic Energy Agency (IAEA) have provided invaluable technical support to IAEA Safeguards. This support has covered practically all aspects of traditional safeguards activities and also those activities recently proposed and introduced for strengthening the safeguards system. As of August 1997, there were fourteen Member States, plus EURATOM, with active programmes in support of IAEA safeguards and the activities conducted under these Member State Support Programmes (MSSPs) are currently valued at an annual twenty million dollars of extra-budgetary contribution to the IAEA. The overall administration in the IAEA of the support programmes is the responsibility of Support Programmes Administration (SPA) in the Safeguards Division of Technical Services. This paper describes the roles and the contributions of the MSSPs, the functions of the MSSP administration activities, and the vital importance the IAEA attaches to the MSSPs. (author)

  1. Residence in Switzerland of partners of members of the personnel

    CERN Multimedia

    2012-01-01

    1. Definitions a) CERN Staff Rules and Regulations Article S IV 1.02 of the Staff Rules defines a "partner", irrespective of gender, as "any person linked to an employed member of the personnel by a partnership officially registered in a Member State". Partners are regarded as family members for the purposes of protection against the financial consequences of illness and accidents. b) Swiss Federal Law Under Swiss federal law, to which the text below essentially refers, the following definitions apply: "partners": a couple of the same sex (linked by a registered partnership), "common-law spouses": a couple of the opposite sex (unmarried). Provided that they are aged 18 or more and are not blood relatives, two people of the same sex ("partners") may officially register their partnership with the competent registry office in order to give it a legal framework (a civil partnership commonly known as the Federal PACS...

  2. Effect of Fiber Reinforcement on the Response of Structural Members

    DEFF Research Database (Denmark)

    Fischer, Gregor; Li, Victor

    2007-01-01

    This paper describes a series of investigations on the effect of fiber reinforcement on the response of structural members in direct tension and flexure under reversed cyclic loading conditions. The design approach of the fiber reinforced cementitious composite is based on fracture mechanics...... principles, which will be described in the first part of the paper along with an introduction of the relevant material properties of the resulting engineered cementitious composite (ECC). This class of composites is characterized by strain hardening and multiple cracking properties in uniaxial tension...... and an ultimate tensile strain capacity on the order of several percent. Subsequently, the synergistic effects of composite deformation mechanisms in the ECC and structural members subjected to large shear reversals are identified. Beneficial effects observed in the reinforced ECC structural members as compared...

  3. The challenges of reintegration for service members and their families.

    Science.gov (United States)

    Danish, Steven J; Antonides, Bradley J

    2013-10-01

    The ongoing wars in Afghanistan and Iraq have posed a number of reintegration challenges to service members. Much of the research focuses on those service members experiencing psychological problems and being treated at the VA. In this article, we contend that much of the distress service members experience occurs following deployment and is a consequence of the difficulties encountered during their efforts to successfully reintegrate into their families and communities. We propose a new conceptual framework for intervening in this reintegration distress that is psycho-educational in nature as well as a new delivery model for providing such services. An example of this new intervention framework is presented. © 2013 American Orthopsychiatric Association.

  4. Bibliometric Analyses Reveal Patterns of Collaboration between ASMS Members

    Science.gov (United States)

    Palmblad, Magnus; van Eck, Nees Jan

    2018-03-01

    We have explored the collaborative network of the current American Society for Mass Spectrometry (ASMS) membership using bibliometric methods. The analysis shows that 4249 members are connected in a single, large, co-authorship graph, including the majority of the most published authors in the field of mass spectrometry. The map reveals topographical differences between university groups and national laboratories, and that the co-authors with the strongest links have long worked together at the same location. We have collected and summarized information on the geographical distribution of members, showing a high coverage of active researchers in North America and Western Europe. Looking at research fields, we could also identify a number of new or `hot' topics among ASMS members. Interactive versions of the maps are available on-line at https://goo.gl/UBNFMQ (collaborative network) and https://goo.gl/WV25vm (research topics). [Figure not available: see fulltext.

  5. Research Performances of Organization of Islamic Conference (OIC) Members.

    Science.gov (United States)

    Khoubnasabjafari, Maryam; Sadeghifar, Eliza; Khalili, Majid; Ansarin, Khalil; Jouyban, Abolghasem

    2012-01-01

    Scientometric analysis of academic institutions provides useful information for policy makers, international and national organizations to invest in the research fields of the institutions to gain more outputs with less cost. The objectives of this work were to report a scientometric analysis of Islamic states considering a number of indicators. The number of articles and patents published by members of organization of Islamic conference were extracted from Scopus(TM) along with the top journals, authors, document type, universities, language of the publications and subjects. The analyses of data revealed that Turkey is the leading country followed by Iran, Egypt, Malaysia and Nigeria when total numbers of indexed articles in Scopus(TM) are considered. When the articles of 2006-2010 are considered the ranks are Turkey, Iran, Malaysia, Egypt and Pakistan. the increased pattern was observed for scientific performances of OIC members however, more investments are required to fill the gap between OIC members and the leading countries.

  6. Intraoperative monitoring technician: a new member of the surgical team.

    Science.gov (United States)

    Brown, Molly S; Brown, Debra S

    2011-02-01

    As surgery needs have increased, the traditional surgical team has expanded to include personnel from radiology and perfusion services. A new surgical team member, the intraoperative monitoring technician, is needed to perform intraoperative monitoring during procedures that carry a higher risk of central and peripheral nerve injury. Including the intraoperative monitoring technician on the surgical team can create challenges, including surgical delays and anesthesia care considerations. When the surgical team members, including the surgeon, anesthesia care provider, and circulating nurse, understand and facilitate this new staff member's responsibilities, the technician is able to perform monitoring functions that promote the smooth flow of the surgical procedure and positive patient outcomes. Copyright © 2011 AORN, Inc. Published by Elsevier Inc. All rights reserved.

  7. ON SOME TERMS DENOTING CREW MEMBERS ON DUBROVNIK SHIPS

    Directory of Open Access Journals (Sweden)

    Ariana Violić-Koprivec

    2015-01-01

    Full Text Available The paper discusses selected terms denoting crew members on Dubrovnik ships throughout the history. The titles of the most important crew members are analyzed based on the corpus of the 18th century documents, literary works, and technical literature. The goal is to determine which terms are typical of the Dubrovnik area, whether their meanings have become restricted or extended, and how they have disappeared or remained in use over the centuries. It is obvious that the importance of individual crew members and their positions changed with time. Their responsibilities occasionally overlapped, and certain terms for their positions coexisted as synonyms, either belonging to the standard or local, i.e. colloquial use. A comparative analysis has revealed some specific features of the Dubrovnik maritime terminology referring to the ship’s crew. The terms škrivan, nokjer, nostromo, pilot, gvardijan and dispensjer are lexemes specific for this area. This is confirmed by their use in literary works.

  8. Military Considerations in Transsexual Care of the Active Duty Member.

    Science.gov (United States)

    Folaron, Irene; Lovasz, Monica

    2016-10-01

    Retention standards and policies applied to active duty members in the U.S. military who identify as transgender have recently been in evolution. The Secretary of Defense recently released a new directive allowing transgender members to serve openly with the option to transition gender while in active duty, abrogating the old policy disqualifying transgender members from continued service. There is a reasonable expectation that some may pursue medical and surgical options toward gender transition. The clinical pathway for gender transition relies heavily on Mental Health and Endocrinology services. This article highlights the medical aspects of gender transition and how they can affect readiness and the delivery of military health care. Reprint & Copyright © 2016 Association of Military Surgeons of the U.S.

  9. Employment Status of the Members of Tehran Deaf Community

    Directory of Open Access Journals (Sweden)

    Shahrooz nemati

    2011-09-01

    Full Text Available Background and Aim: Regarding the importance of employment in social and emotional status of individuals, it would be important for the deaf. The purpose of the present study was to assess the employment status of the members of Tehran deaf community.Methods: This descriptive study was performed on all members of Tehran deaf community. A researchers-made questionnaire which had three parts (demographic information, employment status of the deaf members and their attitudes regarding employment was used in this study. The obtained data were analyzed using descriptive methods.Results: Majority of deaf community members were adult (ages ranging between 18 and 30. Sixty-eight of them (52.5% were female and 53 (47.5% were male, from our participants, 56.2% were unemployed and 43.8% were employed. Main problems were: having no access to facilities regarding their disability (14.5%, communication problems (9.4%, lower salaries because of their disability (12.4%, being far from the working place (15.4%, disproportion of working environment to their disability (11.4%, maltreatment of their coworkers (13.2%, maltreatment of their employer (12.5% and discrimination because of their disability (11.2%, the attitudes of the deaf members were positive regarding the employment in all areas: 90% of them considered it as an essential part of life versus 10% of them mentioned not very important issue.Conclusion: Our findings showed that most of the deaf were supported by their family members, but not by the social facilities or their past education. The social policies should be reformed to support employment of the deaf.

  10. INDIRECT TAXATION TRENDS IN THE EUROPEAN UNION MEMBER STATES

    Directory of Open Access Journals (Sweden)

    MARIUS CRISTIAN MILOŞ

    2014-12-01

    Full Text Available The objective of this paper is to outline the recent dynamics of the indirect taxation in the European Union member states, with a special focus on the Romanian case. We could notice that indirect taxation continues to play an important role for all the member states, in their attempt to recover from the global economic crisis. Morover, we have presented some of the recent changes in the legislative frameworks, which happened with a rather rapid pace, and contributed to a rather challenging business climate.

  11. Members of Parliament of the Islamic Republic of Iran

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    Five members of the Iranian parliament involved in legislation for science, research and education funding in Iran visited CERN in May. They are pictured here in building SM18, which houses the test string for LHC magnets: (left to right) H.E. Mr A. Mojtahed-Shabestari, Deputy Ambassador of the Islamic Republic of Iran in Geneva; Dr D. Blechschmidt, CERN Non Member-State Relations; Dr A.-R. Baharvand MP; Dr H. Amiri MP; Dr N. Siegel, Insertion, Correctors and Protection Group, LHC division; Dr H. Afarideh MP; Dr R. Seddighi MP; and Dr A. Shirzad.

  12. INTERESTS OF THE MEMBER STATES IN THE EURASIAN ECONOMIC UNION

    Directory of Open Access Journals (Sweden)

    Tomasz Michałowski

    2016-12-01

    Full Text Available The article presents the interests of the member countries in the Eurasian Economic Union (EEU, which is formed by Russia, Belarus, Kazakhstan, Armenia and Kyrgyzstan. The author argues that Russia has been involved in the project primarily for geopolitical reasons. Belarus, Kazakhstan, Armenia and Kyrgyzstan have perceived the integration within EEU primarily through the possible economic benefits. While analyzing the interests of the members in the EEU, the author also refers to the development of the economic situation in each country in recent years. The starting point for discussion is the analysis of benefits of economic integration in the light of theory.

  13. Strengthening of the Timber Members Using Fibre Reinforced Polymer Composites

    Directory of Open Access Journals (Sweden)

    Ioana-Sorina Enţuc

    2004-01-01

    Full Text Available The reinforcement of structural wood products has become in the last decades an efficient method of improving structural capabilities of load carrying members made of this material. Some important steps in earlier stages of research were focused on using metallic reinforcement, including steel bars, prestressed stranded cables, and bonded steel and aluminum plates. A disadvantage of the metallic reinforcement was the poor compatibility between the wood and the reinforcing materials. In comparison with metallic reinforcement, fiber reinforced polymers (FRP composites are compatible with structural wood products leading to efficient hybrid members. Some interesting strengthening alternatives using FRP applied to wood beams and to wood columns are presented in this paper.

  14. Nonlinear load-displacement analysis of structures having members ...

    African Journals Online (AJOL)

    Solid or hollow reclan~lar and circular crosssection members are most extensively used in medium and small size steel structures. Such crosssections are non-warping cross-section. They are extensively used because of their strength and the ease to assemble. The governing differential equations and the corresponding ...

  15. Teacher Union Legitimacy: Shifting the Moral Center for Member Engagement

    Science.gov (United States)

    Popiel, Kara

    2013-01-01

    This mixed-method case study explored teacher union members' beliefs about the teacher union and their reasons for being active or inactive in the union. Findings suggest that teacher unions have gained pragmatic and cognitive legitimacy (Chaison and Bigelow in Unions and legitimacy. Cornell University Press, Ithaca, NY, 2002), but that…

  16. The Members of the Agency. List of 20 November 1971

    International Nuclear Information System (INIS)

    1971-01-01

    On 20 November 1971 the Members of the Agency were the 102 States listed. It is to be noted that the United Arab Republic and the Democratic Republic of the Congo became the Arab Republic of Egypt and the Republic of Zaire on 2 September and 27 October 1971 respectively.

  17. Role of Household Members in Kolanut Production and Marketing in ...

    African Journals Online (AJOL)

    This study assessed roles of household members in kolanut production and marketing in Ekiti State, Nigeria. Multistage sampling procedure was used in selecting 80 kolanut farmers. Data were collected from the respondents using structured interview schedule. Data were presented and analyzed using frequency counts, ...

  18. New Faculty Members' Emotions: A Mixed-Method Study

    Science.gov (United States)

    Stupnisky, Robert H.; Pekrun, Reinhard; Lichtenfeld, Stephanie

    2016-01-01

    The current study developed when new faculty members spontaneously reported discrete emotions during focus groups exploring the factors affecting their success. Qualitative analysis using the framework of Pekrun's control-value theory of emotions revealed 18 different emotions with varying frequencies. A follow-up survey of 79 new faculty members…

  19. Burnout and Humor Usage among Community College Nursing Faculty Members.

    Science.gov (United States)

    Talbot, Laura A.

    2000-01-01

    Assesses the correlation of burnout among community college nursing faculty members and their use of humor to mediate academic stress related to burnout. Differences in burnout between high versus low humor usage respondents showed a higher sense of personal accomplishment with high humor usage. Of those with low humor usage, workload was related…

  20. 26 CFR 56.4911-5 - Communications with members.

    Science.gov (United States)

    2010-04-01

    ... a nominal amount of time, or (iii) Is one of a limited number of “honorary” or “life” members who... electing public charity demonstrates to the satisfaction of the Internal Revenue Service that there is a...) States that the recipient should contact a legislator or an employee of a legislative body, or should...

  1. The Members of the Agency. List of 15 October 1962

    International Nuclear Information System (INIS)

    1962-01-01

    The Members of the Agency are the seventy-eight States listed. The dates on which they deposited their respective instruments of ratification or acceptance of the Statute are given, with other relevant information, in the latest version of INFCIRC/16.

  2. The Members of the Agency. List of 31 May 1965

    International Nuclear Information System (INIS)

    1965-01-01

    The Members of the Agency are the ninety-one States listed. The dates on which they deposited their respective instruments of ratification or acceptance of the Statute will be given, with other relevant information, in the latest revision of document INFCIRC/42.

  3. 12 CFR 708a.4 - Disclosures and communications to members.

    Science.gov (United States)

    2010-01-01

    ... average pay higher rates than banks. 3. POTENTIAL PROFITS BY OFFICERS AND DIRECTORS. Conversion to a... UNIONS CONVERSION OF INSURED CREDIT UNIONS TO MUTUAL SAVINGS BANKS § 708a.4 Disclosures and communications to members. (a) After the board of directors has complied with § 708a.3 and approves a conversion...

  4. BMC Medicine editorial board members on open access publishing.

    Science.gov (United States)

    Carmont, Michael R; Lawn, Stephen D; Stray-Pedersen, Babill; Shoenfeld, Yehuda; Meier, Pascal

    2014-01-21

    In recognition of Open Access week (21st-27th October 2013), we asked some BMC Medicine Editorial Board Members to share their views and experiences on open access publishing. In this short video, they highlight the benefits of visibility and dissemination of their research, and discuss the future directions for this model of publishing.

  5. Paper 6: EUROCAT member registries: organization and activities

    DEFF Research Database (Denmark)

    Greenlees, Ruth; Neville, Amanda; Addor, Marie-Claude

    2011-01-01

    EUROCAT is a network of population-based congenital anomaly registries providing standardized epidemiologic information on congenital anomalies in Europe. There are three types of EUROCAT membership: full, associate, or affiliate. Full member registries send individual records of all congenital a...

  6. Powernext 2002: 32 members 30% monthly growth a positive result

    International Nuclear Information System (INIS)

    2002-01-01

    Powernext SA is a Multilateral Trading Facility which organizes and warrants the transactions on the European power exchange market. This activity report presents the highlights of the market and of Powernext in 2002: evolution of prices, power consumption in France, supply and demand, power generation in France, arbitration with other markets, traded volumes, Powernext members. (J.S.)

  7. Fatigue Strength of Reinforced Concrete Flexural Members | Kuryllo ...

    African Journals Online (AJOL)

    It is well known that reinforced concrete flexural members subjected to cyclic loads behave differently compared with static bending and can collapse due to the fatigue of concrete, reinforcement or both when maximum fatigue stresses of concrete and steel are well below the corresponding static strengths. But up till now ...

  8. Party financing and referendum campaigns in EU member states

    NARCIS (Netherlands)

    van Klingeren, M.; Orozco, M.; van Spanje, J.; de Vreese, C.

    2015-01-01

    This study has been prepared by the Amsterdam School of Communication Research (ASCoR), part of the Faculty of Social and Behavioural Sciences, University of Amsterdam (UvA). It comprises 1) an up-to-date inventory of party finance rules within the EU Member States, 2) an overview of the regulations

  9. 75 FR 81145 - Members of Federal Home Loan Banks

    Science.gov (United States)

    2010-12-27

    ... financial reports must show that it originates or purchases such loans. In theory, an applicant could... context of the home financing policy requirement, the absence of any qualitative standards as to the form... members. With respect to the 10 percent requirement, initial research indicates that, of the approximately...

  10. The Impact of Having Children on Party Member Activism

    DEFF Research Database (Denmark)

    Kosiara-Pedersen, Karina

    2014-01-01

    party member survey of 2012, analyses show: First, the cost of having children is more important when explaining more demanding activities than the less demanding activities, and, second, the impact of the cost of having children in the household is larger when including the intensity of participation...

  11. 7 CFR 1717.307 - Distribution members' rates.

    Science.gov (United States)

    2010-01-01

    ... affairs of the power supply borrower and over the rates of its distribution members: Provided, however, that the state regulatory authority shall treat any RUS approved rate for the power supply borrower as... Federal Pre-emption in Rate Making in Connection With Power Supply Borrowers § 1717.307 Distribution...

  12. Learning Conditions, Members' Motivation and Satisfaction: A Multilevel Analysis

    Science.gov (United States)

    Dimas, Isabel Dórdio; Rebelo, Teresa; Lourenço, Paulo Renato

    2015-01-01

    Purpose: The purpose of this paper was to contribute to the clarification of the conditions under which teams can be successful, especially those related to team learning. To attain this goal, in the present study, the mediating role played by team members' motivation on the relationship between team learning conditions (shared learning beliefs…

  13. Exploring the stigma related experiences of family members of ...

    African Journals Online (AJOL)

    The stigma of families is seen in the form of assignment of blame, social isolation and rejection. This stigma subsequently perpetuates a cycle of disability on the part of the patient and family. Purpose: To explore the stigma related experiences of family members of persons with mental illness in a selected community in the ...

  14. Gender Difference and Church Member Satisfaction: An Appraisal ...

    African Journals Online (AJOL)

    A number of practitioner books, web-sites, and lay-leader seminars have appeared in recent years with the intent of addressing this issue while offering multiple theories to explain this trend. However, empirical evidence and systematic development of male member profiles that would aid in the development of marketing ...

  15. Distribution and origins of members of the Family Portulacaceae ...

    African Journals Online (AJOL)

    The present day distribution of members of the family Portulacaceae shows that whilst some genera such as Portulaca L., and to some extent Montia L. and Talinum Adanson are cosmopolitan in distribution, others such as Ceraria Pearson and Stephens, Lyallia Hooker fil., Portulacaria Jacquin, Silvaea Philippi and ...

  16. Effects of Hurricane Hugo: Mental Health Workers and Community Members.

    Science.gov (United States)

    Muzekari, Louis H.; And Others

    This paper reports the effects of Hurricane Hugo on mental health workers and indigenous community members. The response and perceptions of mental health staff from the South Carolina Department of Mental Health (Go Teams) from areas unaffected by the hurricane were compared and contrasted with those of a subsequent Hugo Outreach Support Team…

  17. Plasma generator utilizing dielectric member for carrying microwave energy

    International Nuclear Information System (INIS)

    Aklufi, M.E.; Brock, D.W.

    1991-01-01

    This patent describes a system in which electromagnetic energy is used to generate a plasma from a gas. It comprises a reaction chamber which is evacuated to less than ambient pressure and into which the gas is introduced; and a nonconductive member for carrying the electromagnetic energy and for emitting the electromagnetic energy so that a plasma is formed from the gas

  18. 12 CFR 1261.3 - Designation of member directorships.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Designation of member directorships. 1261.3 Section 1261.3 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS FEDERAL HOME LOAN BANK DIRECTORS Federal Home Loan Bank Boards of Directors: Eligibility and Elections § 1261.3...

  19. 2006 Gender Relations of Active-Duty Members

    Science.gov (United States)

    2008-03-01

    training, social retaliation within one’s work setting, and overprotection . Professional and social retaliation might also occur in combination...alone. Six percent indicated they experienced some form of overprotection , such as being smothered or treated like a child. Among men who...alone, professional and social retaliation, or overprotection were not reportable. Figure 32. Percent of Service Members Indicating Negative Responses

  20. A Family Affair : Explaining Co-Working By Family Members

    NARCIS (Netherlands)

    Ruijter, Esther de; Lippe, Tanja van der; Raub, Werner; Weessie, Jeroen

    2008-01-01

    This study focuses on co-working by intimate partners and other family members in entrepreneurs’ businesses. We hypothesize that co-working by family is beneficial because it reduces trust problems associated with employment relations. On the other hand, co-working is risky because co-working family

  1. EU member states' voting for authorizing genetically engineered crops

    NARCIS (Netherlands)

    Smart, Richard D.; Blum, Matthias; Wesseler, Justus

    2015-01-01

    Several authors suggest a gridlock of the European Union's (EU's) approval process for genetically engineered (GE) crops. We analyse the voting behaviour of EU Member States (MSs) for voting results from 2003 to 2015 on the approval of GE crops to test for a gridlock; no reliable data are

  2. Social Cues of (Un)Trustworthy Team Members

    Science.gov (United States)

    Neu, Wayne A.

    2015-01-01

    This study investigates the way in which and the extent to which students engage in social categorization during the process of self-selecting team members for a team assignment. The discovery-oriented method of grounded theory was used. Data were gathered from a sample of 38 undergraduate marketing and management students using the Zaltman…

  3. Enhancing Adaptivity and Resilience through Team Member Change

    Science.gov (United States)

    Thompson, Kevin S.; Noble, David

    2017-01-01

    The interest in aligning college graduates' skills, competencies, and experiences with what employers desire continues across academia. Employers seek higher levels of resilience than they see in most new employees. This article provides a review of the employee resilience literature and describes a team member change scenario focused on enhancing…

  4. Synthesis and characterization of six-membered pincer ...

    Indian Academy of Sciences (India)

    0013167

    SUPPORTING INFORMATION. REGULAR ARTICLE. Synthesis and characterization of six-membered pincer nickelacycles and application in alkylation of benzothiazole. †. HANUMANPRASAD PANDIRI,a DIPESH M SHARMA,a RAJESH G GONNADEb and. BENUDHAR PUNJI*,a. aOrganometallic Synthesis and Catalysis ...

  5. Leader–Member Skill Distance, Team Cooperation, and Team Performance

    DEFF Research Database (Denmark)

    Tian, Longwei; Li, Yuan; Li, Peter Ping

    2015-01-01

    member skill distance on team performance. We find the empirical support for our views with a mixed-methods design: a qualitative study interviewing informants in different cultures to clarify the psychological mechanisms, and also a quantitative study analyzing the data from US’s National Basketball...

  6. Exploring the stigma related experiences of family members of ...

    African Journals Online (AJOL)

    Celenkosini Thembelenkosini Nxumalo

    a cycle of disability on the part of the patient and family. Purpose: To explore the stigma .... prevention of stigmatisation of people with mental illness and their families in rural ... as a family member's accounts of stigma related feelings, situations or ..... ishment from the family as a reason for the bad behaviour. The participants ...

  7. Macroeconomic sources of foreign exchange risk in new EU members

    NARCIS (Netherlands)

    Kocenda, Evzen; Poghosyan, Tigran

    2009-01-01

    We address the issue of foreign exchange risk and its macroeconomic determinants in several new EU members. We derive the observable macroeconomic factors-consumption and inflation-using the Stochastic discount factor (SDF) approach. The joint distribution of excess returns in the foreign exchange

  8. Monkey Bites among US Military Members, Afghanistan, 2011

    Science.gov (United States)

    Baker, Katheryn A.

    2012-01-01

    Bites from Macaca mulatta monkeys, native to Afghanistan, can cause serious infections. To determine risk for US military members in Afghanistan, we reviewed records for September–December 2011. Among 126 animal bites and exposures, 10 were monkey bites. Command emphasis is vital for preventing monkey bites; provider training and bite reporting promote postexposure treatment. PMID:23017939

  9. AIP Member Societies Entering the 1980's. AIP Report.

    Science.gov (United States)

    Porter, Beverly Fearn

    Information is presented on the composition of the 1979 membership of the American Institute of Physics (AIP). Questionnaires were administered to members of the nine independent societies of the AIP to determine demographic and employment information. Background characteristics of the membership include the following: more than half identify…

  10. Reasons for the migration of church members from one ...

    African Journals Online (AJOL)

    The effects of secularisation and the Enlightenment, and their consequences at various levels, as well as the theories of McDonaldisation and Consumerism were taken into consideration to explain the migration of church members between congregations. The answer is not simple in the sense that two tendencies can be ...

  11. Leader-Member Exchange Theory in Higher and Distance Education

    Science.gov (United States)

    Power, Robert Leo

    2013-01-01

    Unlike many other prominent leadership theories, leader-member exchange (LMX) theory does not focus on the specific characteristics of an effective organizational leader. Rather, LMX focuses on the nature and quality of the relationships between a leader and his or her individual subordinates. The ideal is for a leader to develop as many…

  12. Leader-Member Exchange, Learning Orientation and Innovative Work Behavior

    Science.gov (United States)

    Atitumpong, Aungkhana; Badir, Yuosre F.

    2018-01-01

    Purpose: This study aims to examine the effects of leader-member exchange (LMX) and employee learning orientation on employee innovative work behavior (IWB) through creative self-efficacy. Design/methodology/approach: Data have been collected from 337 employees and 137 direct managers from manufacturing sector. A hierarchical linear model has been…

  13. 21 CFR 14.95 - Compensation of advisory committee members.

    Science.gov (United States)

    2010-04-01

    ... employees, but are reimbursed by the Food and Drug Administration for travel expenses. (b) Notwithstanding... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Compensation of advisory committee members. 14.95 Section 14.95 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL...

  14. MC Marumoagae A NON-MEMBER SPOUSE'S ENTITLEMENT

    African Journals Online (AJOL)

    10332324

    Nevondwe 2012 Insurance and Tax as well as Marumoagae 2013 De Rebus 40, where ... interest" is as an asset in the joint estate of spouses married in community of ... ordering that the member spouse's retirement fund would have to make ..... court and the terms thereof may guide the pension fund scheme on how to deal.

  15. Leader-member exchange, work engagement and job performance

    NARCIS (Netherlands)

    Breevaart, K.; Bakker, A.B.; Demerouti, E.; van den Heuvel, M.

    2015-01-01

    Purpose – The purpose of this paper is to examine the process through which leader-member exchange (LMX) is related to followers’ job performance. Integrating the literature on LMX theory and resource theories, the authors hypothesized that the positive relationship between LMX and employee job

  16. Leader-member exchange, work engagement, and job performance.

    NARCIS (Netherlands)

    Breevaart, K.; Bakker, A. B.; Demerouti, E.; Van den Heuvel, M.

    2015-01-01

    Purpose - The purpose of this paper is to examine the process through which leader-member exchange (LMX) is related to followers’ job performance. Integrating the literature on LMX theory and resource theories, the authors hypothesized that the positive relationship between LMX and employee job

  17. Leader-member exchange, work engagement, and job performance

    NARCIS (Netherlands)

    Breevaart, K.; Bakker, A.B.; Demerouti, E.; van den Heuvel, M.

    2015-01-01

    Purpose - The purpose of this paper is to examine the process through which leader-member exchange (LMX) is related to followers’ job performance. Integrating the literature on LMX theory and resource theories, the authors hypothesized that the positive relationship between LMX and employee job

  18. 7 CFR 932.129 - Nomination procedures for producer members.

    Science.gov (United States)

    2010-01-01

    ... choose the district in which the producer will vote and notify the Committee of that choice. If the... producer wishes to participate shall be the producer's choice. (4) Any member of a producer's family (husband, wife, son or daughter) may vote on behalf of an owner-operated, landlord-tenant, family...

  19. 76 FR 28960 - National Security Education Board Members Meeting

    Science.gov (United States)

    2011-05-19

    ... DEPARTMENT OF DEFENSE Office of the Secretary National Security Education Board Members Meeting...: Pursuant to Public Law 92-463, notice is hereby given of a forthcoming meeting of the National Security... Defense concerning requirements established by the David L. Boren National Security Education Act, Title...

  20. 77 FR 49439 - National Security Education Board Members Meeting

    Science.gov (United States)

    2012-08-16

    ... DEPARTMENT OF DEFENSE Office of the Secretary National Security Education Board Members Meeting...: Pursuant to Public Law 92-463, notice is hereby given of a forthcoming meeting of the National Security... Secretary of Defense concerning requirements established by the David L. Boren National Security Education...

  1. 77 FR 9214 - National Security Education Board Members Meeting

    Science.gov (United States)

    2012-02-16

    ... DEPARTMENT OF DEFENSE Office of the Secretary National Security Education Board Members Meeting... meeting of the National Security Education Board. The purpose of the meeting is to review and make... p.m. ADDRESSES: Defense Language and National Security Education Office, 1101 Wilson Boulevard...

  2. 77 FR 27739 - National Security Education Board Members Meeting

    Science.gov (United States)

    2012-05-11

    ... DEPARTMENT OF DEFENSE Office of the Secretary National Security Education Board Members Meeting...: Pursuant to Public Law 92-463, notice is hereby given of a forthcoming meeting of the National Security... Defense concerning requirements established by the David L. Boren National Security Education Act, Title...

  3. Organisational commitment levels of faculty members in sport ...

    African Journals Online (AJOL)

    This study aimed to reveal the organisational commitment levels of faculty members to teaching at higher education institutions in Turkey. To be able to obtain participants' views, the organisational commitment scale developed by Allen and Meyer in 1990 was used and data was analysed by means of the SPSS 17.0 ...

  4. Social Influences on Sorority and Fraternity Member Smoking

    Science.gov (United States)

    Cheney, Marshall K.; Maness, Sarah; Huber, J. Kathleen; Burt, Taylor; Eggleston, Landon; Naberhaus, Bryce; Nichols, Brooklyn

    2017-01-01

    Objective: To understand how the Greek system uniquely influences smoking attitudes, beliefs, and behaviors among college students who belong to a social sorority or fraternity. Participants: Active members of sororities (n = 16) and fraternities (n = 17) were interviewed between February 2013 and October 2015. Methods: In-depth interviews were…

  5. Inflation persistence : euro area and new EU member states

    Czech Academy of Sciences Publication Activity Database

    Franta, Michal; Saxa, Branislav; Šmídková, K.

    -, č. 810 (2007), s. 1-39 ISSN 1725-2806 R&D Projects: GA MŠk LC542 Institutional research plan: CEZ:AV0Z70850503 Keywords : inflation persistence * new EU member states * time varying mean Subject RIV: AH - Economics http://www.ecb.int/pub/pdf/scpwps/ecbwp810.pdf

  6. The Effect of Multitasking to Faculty Members' Academic Works

    Science.gov (United States)

    Baran, Bahar

    2013-01-01

    Faculty members in higher education institutions which technology produced in and used actively try to overcome simultaneous one more works because of their intensive works and responsibilities. This study associated simultaneously doing one more academic works to multitasking. Multitasking may have a detrimental effect on academic works since it…

  7. 76 FR 7623 - Department of State Performance Review Board Members

    Science.gov (United States)

    2011-02-10

    ...: February 2, 2011. Nancy J. Powell, Director General of the Foreign Service and Director of Human Resources... following individuals to the Department of State Performance Review Board for Non-Career Senior Executive Service members: Jeanne-Marie Smith, Chairperson, Senior Advisor, Deputy Secretary for Management and...

  8. Minority faculty members' resilience and academic productivity: are they related?

    Science.gov (United States)

    Cora-Bramble, Denice; Zhang, Kehua; Castillo-Page, Laura

    2010-09-01

    To explore whether there is a relationship between resilience and academic productivity of minority faculty members in U.S. academic health centers. For the purposes of the study, the authors defined academic productivity as peer-reviewed and non-peer-reviewed publications, grants, and academic promotion. In 2007, the authors simultaneously collected quantitative and qualitative data by using a triangulation (mixed-method) design. Past participants in the Association of American Medical Colleges' Minority Faculty Career Development Seminar completed the Web-based 70-item Personal Resilience Questionnaire (PRQ). In addition, two focus groups were conducted with past seminar participants. Seventy-four minority faculty members completed the PRQ, and 15 participated in the two focus groups. The quantitative data showed a positive correlation between demographic, educational, and academic productivity variables and certain resilience subscale scores. Common themes that emerged from the qualitative data were categorized under four major domains: existing barriers to academic advancement, internal protective factors or cultural buffers, external institutional or environmental facilitators, and necessary attributes for ensuring academic productivity and advancement. Certain resilience subscales showed correlation with academic productivity of minority faculty members, and specific personal and/or cultural characteristics were identified as enablers. Minority faculty members may benefit from skill development and coaching that extends beyond the traditional scope of faculty development programs and that specifically targets modifiable resilience characteristics. Additional research is needed, but such nontraditional, resilience-centered intervention strategies may positively affect the advancement of minority faculty in academic medicine.

  9. Improving Acceptance, Integration, and Health Among LGBT Service Members

    Science.gov (United States)

    2017-10-01

    through multiple rounds of internal testing and quality assurance procedures. Recruitment for the Phase II survey was initiated on August 25, 2017...Award Numbers: W81XWH-15-1-0701 Title: Improving Acceptance, Integration, and Health Among LGBT Service Members Principal Investigators...burden to Department of Defense, Washington Headquarters Services , Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis

  10. 48 CFR 5.403 - Requests from Members of Congress.

    Science.gov (United States)

    2010-10-01

    ..., business confidential information, or information prejudicial to competitive acquisition, the contracting... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Requests from Members of Congress. 5.403 Section 5.403 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION...

  11. Demographic and Behavioral Characteristics of Osher Lifelong Learning Institute Members

    Science.gov (United States)

    Hansen, Robert Jack; Brady, E. Michael; Thaxton, Steven P.

    2016-01-01

    The number of lifelong learning institutes (LLIs) is growing across the United States and it is important for educational planners and administrators to know about current demographic and behavioral characteristics of program participants. A 14-question survey was administered via SurveyMonkey to members who use computers in eight Osher Lifelong…

  12. reasons for the migration of church members from one congregation

    African Journals Online (AJOL)

    of 'church-free' and thus churchless members is also familiar. Less well ... to join. This choice is being made increasingly less on the basis of the ..... McDonaldisation, by Erre (2009:21-42), and in that of Consumer Culture, by. Conradie ...

  13. Organizational Members as Storywriters: On Organizing Practices of Reflexivity

    Science.gov (United States)

    Gherardi, Silvia; Cozza, Michela; Poggio, Barbara

    2018-01-01

    Purpose: The purpose of this paper is to describe how organizational members became storywriters of an important process of organizational change. Writing became a practice designed to create a space, a time and a methodology with which to author the process of change and create a learning context. The written stories produced both the…

  14. Regulatory Inspection of Nuclear Power Plants in NEA Member Countries

    International Nuclear Information System (INIS)

    1978-01-01

    Based on the replies to a questionnaire, this report gives a description and comparative evaluation of the regulatory inspection activities in several NEA Member countries. The questionnaire which was circulated to all Member countries requested details on the organisation, system, scope and objectives of nuclear regulatory inspection and the effort required throughout all stages of the life of a nuclear plant including the use of independent bodies or consultants. Additional information was requested on the documentation concerned with regulatory inspections, incident and accident reporting procedures, and the duties, powers and bases for recruitment of regulatory personnel with the object of covering all related aspects. However, because of the differences in national practices and perhaps in the interpretation of the questionnaire, it proved to be extremely difficult to make an evaluation and comparison of inspection activities and effort involved in these Member countries. This report, which includes a section on the nuclear power programme in Member countries, should therefore only be regarded as an initial review but it provides a useful contribution to the exchange of experience and views on regulatory inspection practices

  15. Knowledge of diabetes and hypertension among members of ...

    African Journals Online (AJOL)

    Diabetes and hypertension are among the most common non-communicable diseases (NCD) that contribute to a large number of adult morbidity and mortality. The objective of this study was to determine knowledge of diabetes and hypertension and the associated risk factors among members of teaching staff of Higher ...

  16. Knowledge And Attitude Of Youth Corps Members In Lagos To ...

    African Journals Online (AJOL)

    Sickle cell disease has remained a public health problem in Nigeria. This study was carried out to determine the knowledge and attitudes of unmarried NYSC members in Lagos State to sickle cell disease and screening. This study was a cross sectional study. Multistage sampling technique was used to select the ...

  17. Faculty Member's Guide to U.S. Immigration Law. Revised.

    Science.gov (United States)

    Smith, Eugene H.; Baron, Marvin J.

    Immigration laws and regulations pertaining to foreign students and scholars are summarized as an aid to faculty members. Basic immigration documents and terminology are explained, including the passport, visa, immigration status or classification, Form 1-20 ID, the "green card", and Departure Record. Classes of nonimmigrants are described,…

  18. 76 FR 80902 - Senior Executive Service; Performance Review Board; Members

    Science.gov (United States)

    2011-12-27

    ... COURT SERVICES AND OFFENDER SUPERVISION AGENCY FOR THE DISTRICT OF COLUMBIA Senior Executive Service; Performance Review Board; Members AGENCY: Court Services and Offender Supervision Agency for the... agency's Senior Executive Service. The PRB established for the Court Services and Offender Supervision...

  19. Responding to Mission Creep: Faculty Members as Cosmopolitan Agents

    Science.gov (United States)

    Gonzales, Leslie D.

    2012-01-01

    Across the field of U.S. higher education, regional teaching and comprehensive universities are striving for national research status. This tendency has most often been explored at the organizational level, but in this paper, the views and actions of faculty members are the unit of analysis. Based on qualitative data, I put forward a three pronged…

  20. Satisfaction with virtual communities of interest : Effect on members' visit frequency

    NARCIS (Netherlands)

    de Valck, Kristine; Langerak, Fred; Verhoef, Peter C.; Verlegh, Peeter W. J.

    The authors develop a four-dimensional scale to measure members' satisfaction with virtual communities of interest (VCIs). The dimensions consist of members' satisfaction with member-to-member interactions, organizer-to-member interactions and organizer-to-community interactions, all of which come

  1. The Perceptions of Georgia School Board Members' Need for Training on School Board Governance

    Science.gov (United States)

    Nutt, Pamela Studdard

    2010-01-01

    This study explored the perceptions of training needs of school board members in Georgia. The study examined perceptions of school board chairs, board members with 1 to 5 years experience, members with 6 to 10 years experience, members with 11 to 15 years experience and board members with 16 plus years experience in the areas of school board…

  2. American Thoracic Society member survey on climate change and health.

    Science.gov (United States)

    Sarfaty, Mona; Bloodhart, Brittany; Ewart, Gary; Thurston, George D; Balmes, John R; Guidotti, Tee L; Maibach, Edward W

    2015-02-01

    The American Thoracic Society (ATS), in collaboration with George Mason University, surveyed a random sample of ATS members to assess their perceptions of, clinical experiences with, and preferred policy responses to climate change. An e-mail containing an invitation from the ATS President and a link to an online survey was sent to 5,500 randomly selected U.S. members; up to four reminder e-mails were sent to nonrespondents. Responses were received from members in 49 states and the District of Columbia (n = 915); the response rate was 17%. Geographic distribution of respondents mirrored that of the sample. Survey estimates' confidence intervals were ±3.5% or smaller. Results indicate that a large majority of ATS members have concluded that climate change is happening (89%), that it is driven by human activity (68%), and that it is relevant to patient care ("a great deal"/"a moderate amount") (65%). A majority of respondents indicated they were already observing health impacts of climate change among their patients, most commonly as increases in chronic disease severity from air pollution (77%), allergic symptoms from exposure to plants or mold (58%), and severe weather injuries (57%). A larger majority anticipated seeing these climate-related health impacts in the next 2 decades. Respondents indicated that physicians and physician organizations should play an active role in educating patients, the public, and policy makers on the human health effects of climate change. Overall, ATS members are observing that human health is already adversely affected by climate change and support responses to address this situation.

  3. Organizational culture in nursing schools in Turkey: faculty members' perspectives.

    Science.gov (United States)

    Kantek, F; Baykal, U

    2009-09-01

    Among the benefits of examining an organization's culture are the opportunity to understand the basic mechanisms of the institutional and structural procedures, to determine the need for change and to ensure the development and satisfaction of the faculty members. To determine the perceptions of faculty members of organizational culture at nursing schools in Turkey and to examine different perceptions in relation to demographic variables. The study was conducted with 180 faculty members from seven nursing schools in state universities located in different geographical regions of Turkey that granted permission for the study. All faculty members in these schools with at least 1 year of institutional experience were included in the research. No sampling was required. A demographic information form and an organizational culture scale were used as data collection materials. The organizational culture scale contains 30 items and resolves the organizational culture in three dimensions. The minimum score obtained was 1 and the maximum was 5. The mean score for faculty members' in total scale was 3.40 (SD = 0.68), while it was 3.26 (SD = 0.77) for the management style dimension, 3.39 (SD = 0.73) for the organizational commitment/relations dimension and 3.68 (SD = 0.73) for the student-oriented dimension. There was no statistical difference between the perception of organizational culture and work experience at the institution, marital status or educational status, but there were differences in age, number of years in the profession and academic titles. It was found that strong perceptions have been established in nursing schools in regard to student-oriented practices, and that groups consisting of senior academic personnel and experienced academicians are considered to be better at perceiving the importance of the organizational culture. The administrators are recommended to promote policies to enhance the participation in decision-making processes and regularly monitor

  4. 78 FR 13706 - Notice of Appointment of Individuals To Serve as Members of Performance Review Board

    Science.gov (United States)

    2013-02-28

    .... Pearson Vice-Chair of the PRB: Commissioner Dean A. Pinkert Member--Catherine DeFilippo Member--Robert B... Member--Lyn M Schlitt FOR FURTHER INFORMATION CONTACT: Patricia Connelly, Director of Human Resources, U...

  5. 78 FR 49276 - Advisory Committee on Organ Transplantation; Request for Nominations for Voting Members

    Science.gov (United States)

    2013-08-13

    ... 25 members, who are Special Government Employees, and 5 ex-officio, non-voting members. Members and... committees; and therefore, extends particular encouragement to nominations for appropriately qualified female...

  6. Tension stiffening in partially prestressed concrete flexural members

    International Nuclear Information System (INIS)

    Oukaili, K. N.

    2000-01-01

    Concrete tensile strength is not being zero, cracking does not extend to the neutral axis as assumed in standard cracked section analysis. In addition, un cracked concrete, which exists above the crack tip in the tension zone, contributes to the stiffness of the member. This paper discusses the influence of concrete tensile stress below the neut ural axis position at the cracked section on the tension stiffening phenomenon and deflection of progressively cracking partially prestressed concrete flexural members. The computation of the neutral axis location, which takes into consideration the effect of concrete in tension, can be achieved by solving iteratively tow simultaneous equation derived from forces and moments equilibrium, strain compatibility and linear stress - strain relationship in concrete across the section depth. Once the section depth after cracking is known, it can be used to calculate the effective moment of inertia for deflection analysis. (author). 13 refs., 3 figs., 1 table

  7. Stress experiences of family members of registered sex offenders.

    Science.gov (United States)

    Tewksbury, Richard; Levenson, Jill

    2009-01-01

    The collateral consequences of sex offender registration and notification (SORN) have been well established, although little evidence has supported the efficacy of SORN. Based on the belief that family members provide some of the most consistent, important, and intense forms of support for criminal offenders in general and registered sex offenders (RSOs) more specifically, the experiences of sanctions, losses, and stresses of these individuals is examined. Using survey responses from 584 individuals known to visit online support and advocacy groups for RSOs and their loved ones, this study identifies the stress levels and stressors experienced by this population. Findings show that family members of RSOs experience high levels of social isolation, fear, shame, property damage, and forced residential relocation. Perceived stress is significantly higher for those who are of lower economic means, feel isolated, have high levels of fear and shame/embarrassment, or were forced to move. (c) 2009 John Wiley & Sons, Ltd.

  8. Strategies needed to involve men, other family members.

    Science.gov (United States)

    Barnett, B

    1998-01-01

    Women typically do not make decisions about contraceptive use and family planning on their own, and many women often have little, if any, decision-making power in the home. Strategies are therefore needed to empower women, educate family members, and involve men in reproductive health programs. Policymakers should expand the range of male services and encourage the greater use of male contraceptive methods. Furthermore, health programs should include counseling to help men and women improve their communications skills and conduct education campaigns to inform men about the roles they can play in family planning. Men should also learn about the side effects of both male and female methods, since concern over method side effects can frustrate their support of family planning. Appropriate strategies can be tailored to meet individual group needs. Programs in Madagascar, Bangladesh, Honduras, and Nepal are described as examples of how the support of family members can positively affect family planning use and reproductive health.

  9. Epidemiological criminology: drug use among African American gang members.

    Science.gov (United States)

    Lanier, Mark M; Pack, Robert P; Akers, Timothy A

    2010-01-01

    Epidemiological methods and public health theories can be tied to theories of crime and delinquency and used to create evidence-based policy. Interdisciplinary theoretical approaches to existing, and emerging, public health and criminal justice problems hold great promise. Differential association theory postulates that close association with delinquent peers leads to an increase in deviant activities such as illicit drug use. Social cognitive theory postulates that health behavior change is driven by the interaction of (a) cognitive states that support a health outcome, (b) the social and contextual environment, (c) and individual action. Combined, these theories can be applied to drug eradication programs as well as other health and crime issues. Focus groups and interviews were performed to identify rates of illicit substance use among incarcerated African American adolescent male gang members and nongang members. The policy recommendations illustrate the convergence of criminological and epidemiological theory under the new paradigm of epidemiological criminology or ''EpiCrim.''

  10. Uniaxial Tension Test of Slender Reinforced Early Age Concrete Members

    Directory of Open Access Journals (Sweden)

    Wenbo Zhang

    2011-08-01

    Full Text Available The present study aims to obtain the tensile properties of early age concrete based on a uniaxial tension test employing RC slender members. First, the paper shows that concrete strain is equal to the strain of rebar at the mid-span of the RC member. The tensile Young’s modulus and the strain capacity of early age concrete are estimated using strain measurements. The experiment indicated that the tensile Young’s modulus at an early age is higher than the compressive modulus. This observation was similar to one found in a previous investigation which used a direct tension test of early age concrete. Moreover, the paper describes how an empirical equation for mature concrete can be applied to the relation between uniaxial tensile strength and splitting tensile strength even in early age concrete. Based on a uniaxial tension test, the paper proposes an empirical equation for the relationship between standard bond stresses and relative slip.

  11. Natural frequencies of the frames having curved member

    International Nuclear Information System (INIS)

    Tekelioglu, M.; Ozyigit, H.A.; Ridvan, H.

    2001-01-01

    In-plane and out-of-plane vibrations of a frame having a curved member are studied. Although the analysis is carried out on a frame having a straight and a curve beam, it can be applicable for all the frame type structures. Different end conditions are considered for the system. Rotary inertia and extensional effects are included for the curved member. Finite element method is used as analysis tool. Natural frequencies of the curved beams for different end conditions are calculated first, and then the frequencies of the frames are investigated. The transformation from local coordinates to global coordinates for curved beams needs special attention in the analysis. The results are compared with other methods. (author)

  12. Mycobacterium tuberculosis Complex Members Adapted to Wild and Domestic Animals.

    Science.gov (United States)

    Malone, Kerri M; Gordon, Stephen V

    2017-01-01

    The Mycobacterium tuberculosis complex (MTBC) is composed of several highly genetically related species that can be broadly classified into those that are human-host adapted and those that possess the ability to propagate and transmit in a variety of wild and domesticated animals. Since the initial description of the bovine tubercle bacillus, now known as Mycobacterium bovis, by Theobald Smith in the late 1800's, isolates originating from a wide range of animal hosts have been identified and characterized as M. microti, M. pinnipedii, the Dassie bacillus, M. mungi, M. caprae, M. orygis and M. suricattae. This chapter outlines the events resulting in the identification of each of these animal-adapted species, their close genetic relationships, and how genome-based phylogenetic analyses of species-specific variation amongst MTBC members is beginning to unravel the events that resulted in the evolution of the MTBC and the observed host tropism between the human- and animal-adapted member species.

  13. Tritium labeling of simple 7-membered ring compounds

    International Nuclear Information System (INIS)

    Hiltunen, J.; Peng, C.T.; Yang, Z.C.

    1990-01-01

    Seven-membered ring compounds, from cycloheptane to complex ring structures containing heteroatoms, substituents and fused phenyl rings, were labeled with tritium, using activated and adsorbed tritium. The 7-membered ring structures are generally stable towards reactions with tritium, which allows compounds like 1-benzosuberone, 1-aza-2-methoxy-1-cycloheptane, iminostilbene and clozapine to be labeled to reasonably high specific activities. The best method varies greatly from compound to compound. By optimizing the labeling conditions and use of efficient support exceptionally good results can be obtained. The Pd-on-alumina support gives consistently higher specific activity and less radioimpurity than other supports. Even molecules containing carbon-halogen bond and hydrogen bound to nitrogen can usually be labeled with tritium at stable positions and without dehalogenation. (author)

  14. Improvements in or relating to the manufacture of superconducting members

    International Nuclear Information System (INIS)

    Lee, J.A.; Madsen, P.E.; Hills, R.F.

    1980-01-01

    A method is described for the manufacture of superconducting members; more particularly of a superconducting member comprising a large number of fine superconductive filaments supported in an electrically conductive, non-superconductive matrix. The method embodies a superconductor of A 15 crystal structure having the general formula A 3 B (where A is a substrate metal (preferably niobium or vanadium) and B is one or more elements (e.g. tin, germanium) which when alloyed with A will form the superconductor). The method involves, as one step, forming an alloy of a carrier metal (e.g. copper) with the element B, and an essential condition of the method is that the phosphorus content of the alloy is less than 0.2 per cent by weight. (U.K.)

  15. THE FISCAL PRESSURE IN THE EU MEMBER STATES

    Directory of Open Access Journals (Sweden)

    DOBROTĂ GABRIELA

    2011-03-01

    Full Text Available The development of an economy is determined in a significant proportion by the tax system structure, by how it exercises its functions and ensures the collection of state resources. A high tax efficiency, due to the acceptability of tax provisions are the ideal conditions of any tax system. In this context, it is obvious that most tax systems have undergone significant changes under the impact of the action of a complex system of factors. Increased need for resources in various countries was reflected in attempts to identify the relationship that allows both the securing of the necessary funds and their economic and social development. The quantification of the fiscal pressure on the EU member states show a wide range of tax rates. This paper makes a comparative analysis of the degree of taxation in the EU member states.

  16. Understanding the roles of NHS trust board members.

    Science.gov (United States)

    Deffenbaugh, J

    1996-01-01

    The establishment of NHS trust boards on a business format was a recent innovation resulting from the NHS reforms. In order to realize benefits for patients, it is essential that boards operate effectively. Explores within the framework of corporate governance, the practical implications of board member roles. Drawing on experience of strategy formulation at board level, analyses and clarifies the roles, and presents recommendations to increase board effectiveness.

  17. Stepping Up: Burden Sharing by NATO’s Newest Members

    Science.gov (United States)

    2014-11-01

    trustworthiness as a partner in Bosnia and Herzegovina, Kosovo, Af- ghanistan, and also in Iraq. Now, as a full member of the Alliance, our responsibility in...Rein Lang at the celebrating of the first anniversary of Estonia’s NATO accession,” Tallinn, Estonia, April 4, 2005, available from www.vm.ee/eng...Lang, Rein (Estonian Foreign Minister). “Address by Foreign Minister Rein Lang at the celebration of the first anniversary of Estonia’s NATO accession

  18. Case Report: Rhabdomyolysis in Service Member Following SERE Physical Training

    Science.gov (United States)

    2017-09-19

    hour per response, including the time tor reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and...completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of...Member following SERE physical training. Sb. GRANT NUMBER Sc. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER Capt Matthew A Pombo Se. TASK

  19. Effectiveness of the current method of calculating member states' contributions

    CERN Document Server

    2002-01-01

    At its Two-hundred and eighty-sixth Meeting of 19 September 2001, the Finance Committee requested the Management to re-assess the effectiveness of the current method of forecasting Net National Income (NNI) for the purposes of calculating the Member States' contributions by comparing the results of the current weighted average method with a method based on a simple arithmetic average. The Finance Committee is invited to take note of this information.

  20. Spirituality and job satisfaction among hospice interdisciplinary team members.

    Science.gov (United States)

    Clark, Leah; Leedy, Stephen; McDonald, Laurie; Muller, Barbara; Lamb, Cheryl; Mendez, Tracy; Kim, Sehwan; Schonwetter, Ronald

    2007-12-01

    As a continuing effort to enhance the quality of palliative care for the dying, this study examined (1) the prevalence of spirituality among hospice interdisciplinary team (IDT) members; (2) whether spirituality is related to job satisfaction; and (3) the structural path relationships among four variables: spiritual belief, integration of spirituality at work, self actualization and job satisfaction. The study surveyed 215 hospice IDT members who completed the Jarel Spiritual Well-Being Scale, the Chamiec-Case Spirituality Integration and Job Satisfaction Scales. Multiple regression and structural path modeling methods were applied to explain the path relationships involving all four variables. The IDT members surveyed were: nurses, 46.4%; home health aids, 24.9%; social workers, 17.4%; chaplains, 4.2%; physicians, 2.3%; and other, 4.8%. Ninety-eight percent of the respondents viewed themselves as having spiritual well-being. On a 0-100 scale, IDT staff reported high spiritual belief (mean = 89.4) and they were self-actualizing (mean = 82.6). Most reported high job satisfaction (mean = 79.3) and spiritual integration (mean = 67.9). In multiple regression, spirituality, integration and self-actualization explained 22% of the variation in job satisfaction (R = 0.48; adjusted R(2) = 0.218; df = 3,175; F = 17.2; p = 0.001). Structural path models revealed that job satisfaction is more likely to be realized by a model that transforms one's spirituality into processes of integrating spirituality at work and self actualization (chi(2) = 0.614; df = 1; p = 0.433) than a model that establishes a direct path from spirituality to job satisfaction (chi(2) = 1.65; df = 1; p = 0.199). Hospice IDT member's integration of their spirituality at work and greater self actualization significantly improve job satisfaction.