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Sample records for mellitus tipo ii

  1. Uso de la metformina en la diabetes mellitus tipo II

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    Yohana Salazar ÁLvarez

    2011-03-01

    Full Text Available Metformina es una biguanida eficaz en el control metabólico de la diabetes mellitus tipo II, no insulinodependiente cuando el control dietético falla. Dada su probada eficacia y actual accesibilidad en el mercado de medicamentos en Cuba, para ser utilizada a nivel primario de atención no solo en pacientes sintomáticos sino en la población en riesgo, se presenta este artículo cuyo propósito es actualizar a los especialistas de Medicina General Integral y Medicina Interna acerca de aspectos de interés relacionados con este medicamento, como: interacciones medicamentosas, enfermedades concomitantes, la biotransformación de la droga y los posibles efectos adversos que se pueden asociar a su uso. Se presentan consideraciones finales acerca del uso de esta droga.

  2. Xantomas eruptivos asociados a diabetes mellitus tipo II e hipertrigliceridemia: reporte de un caso

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    Victoria Bárzaga, Héctor Oscar; Ramos Cabrera, Asmell; Lazo Sánchez, Laura

    2009-01-01

    Se reporta el caso de un hombre de raza blanca, 37 años de edad, hijo de madre con diabetes mellitus tipo 1, con antecedentes patológicos personales de padecer de obesidad exógena desde aproximadamente cinco años. Comenzó a presentar de forma diseminada una erupción papulosa de color amarillento, que se diagnosticó clínicamente e histológicamente como xantomas eruptivos asociados a diabetes mellitus tipo 2 de debut e hipertrigliceridemia. Se describen las generalidades de los xantomas eruptiv...

  3. Uso de la metformina en la diabetes mellitus tipo II Use of metformin to treat type 2 diabetes mellitus

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    Yohana Salazar ÁLvarez

    2011-03-01

    Full Text Available Metformina es una biguanida eficaz en el control metabólico de la diabetes mellitus tipo II, no insulinodependiente cuando el control dietético falla. Dada su probada eficacia y actual accesibilidad en el mercado de medicamentos en Cuba, para ser utilizada a nivel primario de atención no solo en pacientes sintomáticos sino en la población en riesgo, se presenta este artículo cuyo propósito es actualizar a los especialistas de Medicina General Integral y Medicina Interna acerca de aspectos de interés relacionados con este medicamento, como: interacciones medicamentosas, enfermedades concomitantes, la biotransformación de la droga y los posibles efectos adversos que se pueden asociar a su uso. Se presentan consideraciones finales acerca del uso de esta droga.Metformin is an effective biguanide for the metabolic control of non-insulin dependent type 2 diabetes mellitus when the dietary control fails. Given its proven efficacy and present accessibility in the pharmaceutical market in Cuba -to be used at primary health care not only in symptomatic patients but in the population at risk-this article was presented to update the knowledge of the Family Medicine and Internal Medicine specialists about interesting aspects related to this drug, i.e, drug interactions, concomitant diseases, drug biotransformation and the possible adverse effects associated to its use. Final remarks on the use of this drug were stated.

  4. mellitus tipo 2

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    Margarita Lazcano-Ortiz

    2008-01-01

    Full Text Available Objetivo: valorar las propiedades psicométricas de la escala de afrontamiento y proceso de adaptación de Roy en población mexicana. Materiales y métodos: la escala se aplicó a 200 participantes con diabetes mellitus tipo 2. Para validar el constructo se realizó la extracción de factores con componentes principales y rotación Varimax, con Eigenvalores por arriba de 1 y cargas de factor mayores a ,30. Resultados: seis reactivos fueron eliminados del análisis por mostrar correlación negativa con la correlación total de la escala. El análisis de componentes principales inicial reveló nueve factores con una variación explicada de 65,29%. Sin embargo, no se consideraron tres factores por contener cada uno de ellos solamente un reactivo. Por tanto, la escala final se acepta con 38 reactivos. El coeficiente de confiabilidad Alfa de Cronbach fue de, 93. Discusión: el análisis reveló seis factores, uno más de lo reportado por Roy, y con mayor variación explicada. Algunos reactivos parecen no ser bien comprendidos por los participantes. Conclusiones: este artículo aporta una aproximación metodológica para explorar la adecuación de un instrumento a una población diferente para la que originalmente fue diseñado. Se concluye que la escala tiene consistencia interna y validez de constructo incipiente, los datos reportados en este estudio deben tomarse en cuenta con cautela. Es conveniente revisar de nuevo los reactivos y adecuarlos a la cultura particular, y probar la escala de nuevo con pacientes con enfermedades crónicas degenerativas a fin de contar con instrumentos culturalmente equivalentes.

  5. MELLITUS TIPO 1

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    Luciana Vládia Carvalhêdo Fragoso

    2010-01-01

    Full Text Available Investigación de carácter cualitativo, con el objetivo de comprender las experiencias cotidianas de los adolescentes con diabetes tipo 1. Los sujetos del estudio son 14 adolescentes atendidos en una clínica para la diabetes en Fortaleza, Ceará, Brasil, de junio a octubre de 2008. La recolección de los datos se hizo a través de entrevistas semi-estructuradas y se organizaron de acuerdo al análisis de contenido de Morse y Field. Se observó que el descubrimiento de la diabetes fue un momento difícil para los adolescentes debido a los cambios que tuvieron que hacer como el control terapéutico. Hacer una dieta adecuada es muy difícil como consecuencia de estímulos internos y externos a que están sometidos y a las dificultades financieras. Los adolescentes tienen el apoyo de la familia y amigos para su tratamiento diario. Además, les gusta el servicio realizado por los profesionales de salud de la clínica. Sin embargo, hay mucho que mejorar como enfermeras en la valorización de las experiencias de la vida de los adolescentes con diabetes, como la identificación de factores que interfieren en el control metabólico.

  6. EFECTOS DE UN PROGRAMA COGNITIVO COMPORTAMENTAL SOBRE LOS NIVELES DE ESTRÉS Y GLUCEMIA EN PACIENTES CON DIABETES MELLITUS TIPO II

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    Delgado Maigual, Luis Carlos; Hidalgo Villarreal, Guillermo Andrés; Villalobos Galvis, Fredy Hernán

    2011-01-01

    En este estudio se determinaron los efectos de la aplicación de un programa cognitivo-comportamental sobre los niveles de estrés y glucemia en pacientes con diabetes mellitus tipo II de la Fundación Hospital San Pedro de San Juan de Pasto. Para ello, se determinaron los niveles de estrés y glucemia antes de la aplicación del programa de intervención; luego se diseñó y aplicó el programa a los participantes (el cual está sustentado en el modelo procesual de estrés de Lazarus y Folkman) y final...

  7. Catarata e diabetes mellitus tipo 1

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    Pizzol,Melissa Manfroi Dal; Esteves,Jorge Freita; Sccoco,Caio Augusto; Roggia,Murilo Felix; Rosa,Carolina Maurente da; Lambert,José Humberto Franco; Canani,Luís Henrique

    2008-01-01

    OBJETIVO: Avaliar a prevalência de catarata e seus fatores de risco em uma população portadora de diabetes mellitus tipo 1 (DM1). MÉTODOS: Estudo de casos e controles de um banco de dados de 181 pacientes (362 olhos) com diagnóstico de diabetes mellitus tipo 1. Os pacientes foram classificados como casos quando apresentavam diagnóstico de catarata. As variáveis estudadas foram a presença ou não de retinopatia diabética, tratamento com panfotocoagulação, presença de hipertensão arterial sistêm...

  8. Complicaciones tardías en diabetes mellitus tipo 2 en el Hospital II Essalud - Cañete

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    Charlton Fernando Untiveros Mayorga

    2004-04-01

    Full Text Available Objetivo: Determinar las características clínicas y las complicaciones tardías en los pacientes con diabetes tipo 2 atendidos en los consultorios de medicina general y del Programa de Diabetes del Hospital II EsSALUD-Cañete. Material y Métodos: Se realizó un estudio descriptivo de serie de casos en el que se evaluaron 94 pacientes con diabetes tipo 2 elegidos aleatoriamente durante su control ambulatorio, realizándose una entrevista y evaluación clínica durante los meses de junio y julio del 2001. Resultados: La población de pacientes estudiada tuvo una edad promedio de 64.56 + 11.61. Cincuenta y tres pacientes eran mujeres (56.4%. El 68.1% de los pacientes recibían hipoglicemiantes orales y el 11.7% requerían del uso de insulina. Los transtornos lipídicos predominantes fueron la elevación del LDL-Colesterol y disminución del HDL-Colesterol. La retinopatía diabética (88.9% e hipertensión arterial (61.3% fueron las complicaciones más frecuentes. Vasculopatía periférica, neuropatía periférica y neuropatía autonómica fueron otras complicaciones crónicas frecuentes halladas en la población de estudio. Conclusiones: Las complicaciones cardiovasculares (micro y macrovasculares en la población de pacientes con diabetes tipo 2 atendidos ambulatoriamente en el Hospital II EsSALUD-Cañete fueron las más frecuentes. (Rev Med Hered 2004; 15:64-69.

  9. Diabetes mellitus tipo 2 y resistencia a la insulina

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    Enrique Cipriani-Thorne

    2010-07-01

    Full Text Available Se analizó la literatura de los últimos 15 años para poder objetivar los temas que son materia de esta comunicación. En primer lugar se analiza en qué consiste el llamado Síndrome Metabólico, sus características; a continuación se resume la historia natural de la Diabetes Mellitus tipo II y su patogenia. Se revisa la importancia de la resistencia a la insulina en el músculo estriado principal órgano de combustión de la glucosa y el factor mitocondrial de la resistencia a la insulina. Se analiza además la importancia de resistencia a la insulina con respecto al metabolismo del hígado y en particular a las alteraciones del metabolismo del colesterol y de los triglicéridos. Se hace un comentario extenso de cómo así la Diabetes Mellitus Tipo II es considerada en la actualidad como una enfermedad de origen inflamatorio y por último se discuten las consecuencias de la hiperinsulinemia, dado que el exceso de insulina es producido por el bloqueo en la línea metabólica de su acción más no en su línea de producir proliferación tisular.(Rev Med Hered 2010;21:160-170.

  10. Espiritualidad e incertidumbre ante la enfermedad en personas con diabetes mellitus tipo 2

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    Gómez Palencia, Isabel Patricia

    2010-01-01

    Objetivo: Determinar la relación entre espiritualidad e incertidumbre presente en personas con situación crónica por diabetes mellitus tipo II. Metodología: abordaje cuantitativo de tipo correlacional de corte transversal, midiendo la espiritualidad con la escala de perspectiva espiritual de Reed, y la incertidumbre con la escala de Mishel. La muestra incluye 163 pacientes, distribuidos en la institución de la ESE Cartagena de Indias; y Fundación MEDICUS “Casa del diabético de Car...

  11. Estresse em mulheres com Diabetes mellitus tipo 2

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    Lessmann, Juliana Cristina; Silva, Denise Maria Guerreiro Vieira da; Nassar, Silvia Modesto

    2011-01-01

    OBJETIVO: O objetivo do estudo foi investigar a relação entre estresse e Diabetes Mellitus Tipo 2 em mulheres. MÉTODO: Estudo transversal prospectivo, desenvolvido com 147 mulheres, utilizando a Escala de Estresse Percebido (PSS). RESULTADOS: Houve associação entre as variáveis testadas, sendo possível inferir que as mulheres com estresse elevado são as que vivenciaram sofrimento e apresentam controle glicêmico alterado, ou seja, com valores superiores a 180 mg/dL. A maioria relatou sofriment...

  12. Terapêutica da diabetes mellitus tipo 1

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    Antunes, Ana Luisa Lopes

    2009-01-01

    Introdução: Diabetes Mellitus (DM) é uma doença metabólica de etiologia múltipla caracterizada por hiperglicemia crónica com distúrbios no metabolismo dos hidratos de carbono, lípidos e proteínas, por deficiências na secreção e/ou acção da insulina. A descoberta da insulina em 1921, foi um grande marco na sua terapêutica, aumentando a esperança e qualidade de vida dos doentes, nomeadamente na DM tipo 1. Tornou-se um fármaco salvador de vidas (life saving). A primeira a ser comercializad...

  13. Diabetes tipo II e resolvinas D1

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    Silva, Isabel Alexandra Marques Batista da

    2015-01-01

    Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz A diabetes é um problema de saúde pública crescente com o envelhecimento da população, os maus hábitos alimentares e o sedentarismo. A obesidade poderá ser causa ou consequência da diabetes tipo II, sendo também um problema crescente de saúde pública. Esta monografia tem como objetivo estudar, com base no conhecimento atual, se as resolvinas D1 são uma alternativa viável na terapêutica da diab...

  14. Estresse em mulheres com Diabetes mellitus tipo 2

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    Juliana Cristina Lessmann

    2011-06-01

    Full Text Available OBJETIVO: O objetivo do estudo foi investigar a relação entre estresse e Diabetes Mellitus Tipo 2 em mulheres. MÉTODO: Estudo transversal prospectivo, desenvolvido com 147 mulheres, utilizando a Escala de Estresse Percebido (PSS. RESULTADOS: Houve associação entre as variáveis testadas, sendo possível inferir que as mulheres com estresse elevado são as que vivenciaram sofrimento e apresentam controle glicêmico alterado, ou seja, com valores superiores a 180 mg/dL. A maioria relatou sofrimento decorrente de problemas nas relações interpessoais, óbito, doença de familiares e solidão. CONCLUSÃO: Mulheres com DM2 que convivem com estresse e/ou sofrimento constituem grupo vulnerável ao desenvolvimento de agravos à saúde demandando aos serviços de saúde o desenvolvimento de estratégias que modifiquem esta situação.

  15. Intervenciones Farmaceuticas en pacientes con Diabetes Mellitus Tipo 2

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    Gladys Mabel Maidana

    Full Text Available Resumen Introducción: La Atención Farmacêutica es la provision responsable de la farmacoterapia con el propósito de alcanzar resultados concretos que mejoren la calidad de vida de los pacientes. Objetivo: Evaluar el impacto de las intervenciones farmacéuticas en pacientes con Diabetes Mellitus Tipo 2. Metodologia: Ensayo Clínico Aleatorizado, con medición de variables antes y después. No probabilísti-co. De conveniencia. Participaron 32 pacientes del grupo intervenido y 32 en grupo control. Se realizaron entrevistas mensuales en un periodo de intervención farmacéutica de 6 meses (desde octubre 2011 hasta junio 2012. Se registraron solo 3 abandonos. Resultados: La edad de los pacientes fue 55,6±10,6 anos. Los pacientes del grupo intervenido mejoraron la glicemia en 34%, donde 24 pacientes tenian el valor (< 130 mg/dL; la hemoglobina glicosilada mejoró 1,9%, donde 15 pacientes lograron los parámetros deseados (< 6,5%. La calidad de vida del grupo inter-venido aumentó de (56,3 a 71,3 % y fue medido con el cuestionario SF-36. En el grupo intervenido se encontraron 80 problemas relacionados con medicamentos, en 27 pacientes, se resolvieron 59; al final del estudio 12 pacientes resolvieron todos los problemas relacionados con medicamentos; se realizaron 254 intervenciones farmacêuticas, el nivel de conocimiento de los pacientes sobre la enfermedad mejoró en 41%, el conocimiento sobre sus medicamentos mejoró en 53%. Conclusión: Las intervenciones farmacêuticas mejoraron los parámetros clínicos de glicemia, hemoglobina glicosilada, optimizaron el uso de medicamentos, disminuyeron los problemas relacionados con medicamentos, mejoraron la calidad de vida de los pacientes.

  16. OTROS TIPOS ESPECÍFICOS DE DIABETES MELLITUS

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    DRA. M. Gabriela Sanzana G.

    2016-03-01

    En las “Diabetes Atípicas” (no incluidas en la clasificación ADA, se mencionan la DM tipo 2 en niños y adolescentes, favorecida por el aumento de la obesidad y del sedentarismo; la diabetes propensa a la cetosis, que debutan en cetoacidosis, con etiopatogenia y evolución de DM2; los Latent Autoinmune Diabetes of Adults (LADA, DM tipo 1 de lenta aparición y la diabetes postrasplante.

  17. Diabetes mellitus tipo 2 y osteoartritis primaria de rodilla

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    Rubén Daniel Arellano-Pérez Vertti

    2017-07-01

    Full Text Available Señor editor: Es nuestro interés dar a conocer los resultados del estudio sobre la asociación entre diabetes tipo 2 y osteoartritis primaria de rodilla en una población del norte de México.

  18. Estudio del fenotipo de haptoglobinas en pacientes con diabetes mellitus tipo 1, en Lima, Perú

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    Arias, Clever; Inga, Miriam; Oré, Raquel; Zapata, Luis; Aquije, Carmen

    2013-01-01

    Objetivos: Determinar el fenotipo de haptoglobina -1/1, 1/2 y 2/2- predominante en una muestra de 36 pacientes con diabetes mellitus tipo I (DM tipo I). Diseño: Observacional con sistema de medición, descriptivo. Institución: Centro de Investigación de Bioquímica y Nutrición, Facultad de Medicina, UNMSM. Participantes: Pacientes con diagnóstico de diabetes mellitus tipo I Intervenciones: En 36 pacientes con diagnóstico de diabetes mellitus tipo I, se realizó medidas antropométricas, evaluacio...

  19. Factores de riesgo de diabetes mellitus tipo 2 en mujeres postmenopaúsicas

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    Acosta Naranjo, William Daniel; Esnal, Virginia

    2012-01-01

    La Diabetes Mellitus tipo 2 (DM 2) es una enfermedad con impacto socio sanitario por su elevada frecuencia y mortalidad cardiovascular. En Uruguay, como en la población mundial, la DM2 es más frecuente en mujeres. Este trabajo describe factores de riesgo en mujeres postmenopaúsicas que nosotros, los investigadores de este manuscrito, atendemos.

  20. Consumo de frutos secos y aceites vegetales en personas con diabetes mellitus tipo 1

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    Ferrer-García, Juan Carlos; Granell Vidal, Lina; Muñoz Izquierdo, Amparo; Sánchez Juan, Carlos

    2015-01-01

    Introducción: estudios recientes han demostrado los beneficios cardiovasculares de la dieta mediterránea enriquecida con aceite de oliva y frutos secos. Las personas con diabetes, que tienen un mayor riesgo de complicaciones cardiovasculares, podrían beneficiarse en gran medida de seguir ese tipo de patrón alimentario. Objetivos: análisis de la ingesta de grasas vegetales procedentes de frutos secos y aceites vegetales en pacientes con diabetes mellitus tipo 1 (DM1). Métodos: estudio transver...

  1. Efecto incretina en el tratamiento de la diabetes mellitus tipo 2

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    Manuel de Jesús Díaz Pérez

    2015-02-01

    Full Text Available El efecto incretina está dado por las funciones del polipéptido insulinotrópico dependiente de glucosa y un péptido similar a glucagón sobre la hiperglucemia en el organismo humano. Desde su descubrimiento ha cobrado un papel cada vez más significativo en la elaboración de nuevos fármacos normoglucemiantes, que logren el control metabólico de los pacientes con diabetes mellitus tipo 2. El objetivo de esta revisión es actualizar la información sobre el efecto incretina, su relación con la diabetes mellitus tipo 2, los fármacos cuyo mecanismo de acción se basa en este fenómeno fisiológico, así como las perspectivas para el futuro inmediato en este tema. Para ello se realizó una revisión bibliográfica, empleando servicios disponibles desde la red Infomed, específicamente: SciELO, Hinari, PubMed y EBSCO. Se resumen aspectos del sustrato fisiológico y fisiopatológico del efecto incretina y su aplicación en la terapéutica de los pacientes con diabetes mellitus tipo 2, así como los resultados positivos que se han logrado hasta el momento en este campo

  2. Development and standardization of radioimmunoassay technique for human proinsulin determining and its use in the study of type II diabetes mellitus associated to obesity; Desenvolvimento e padronizacao da tecnica de radioimunoensaio para a determinacao de pro-insulina humana e sua aplicacao no estudo do diabetes mellitus tipo II associado a obesidade

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    Nascimento, Martha do

    1996-12-31

    The availability of immunoassay methodology for proinsulin is important to define its physiological and pathophysiological significance in humans. Serum concentration of proinsulin are elevated in patients with type II Diabetes Mellitus (NIDDM) and recently diagnosed Type I, so a raised circulating concentration of proinsulin may serve as an early indicator of {beta} cells dysfunction. recently, in NIDDM the serum concentrations of proinsulin and its B-chain-C-peptide junctional split form, des (31-32), were found to correlate with diastolic blood pressure, a risk factor for cardiovascular disease. The development of a sensitive and specific radioimmunoassay (RIA) methodology for proinsulin has been difficult due to its low concentration in serum and the presence of proinsulin conversion intermediates in fluids and tissues. Also other potentially cross-reactive peptides, including insulin and C-peptide, can interfere in the assay. This work describe a highly specific human proinsulin RIA developed by using biosynthetic human proinsulin (hPI) as immunogen, standard and tracer. (author) 133 refs., 17 figs., 36 tabs.

  3. Development and standardization of radioimmunoassay technique for human proinsulin determining and its use in the study of type II diabetes mellitus associated to obesity; Desenvolvimento e padronizacao da tecnica de radioimunoensaio para a determinacao de pro-insulina humana e sua aplicacao no estudo do diabetes mellitus tipo II associado a obesidade

    Energy Technology Data Exchange (ETDEWEB)

    Nascimento, Martha do

    1997-12-31

    The availability of immunoassay methodology for proinsulin is important to define its physiological and pathophysiological significance in humans. Serum concentration of proinsulin are elevated in patients with type II Diabetes Mellitus (NIDDM) and recently diagnosed Type I, so a raised circulating concentration of proinsulin may serve as an early indicator of {beta} cells dysfunction. recently, in NIDDM the serum concentrations of proinsulin and its B-chain-C-peptide junctional split form, des (31-32), were found to correlate with diastolic blood pressure, a risk factor for cardiovascular disease. The development of a sensitive and specific radioimmunoassay (RIA) methodology for proinsulin has been difficult due to its low concentration in serum and the presence of proinsulin conversion intermediates in fluids and tissues. Also other potentially cross-reactive peptides, including insulin and C-peptide, can interfere in the assay. This work describe a highly specific human proinsulin RIA developed by using biosynthetic human proinsulin (hPI) as immunogen, standard and tracer. (author) 133 refs., 17 figs., 36 tabs.

  4. PREJUÍZOS COGNITIVOS EM IDOSOS COM DIABETES MELLITUS TIPO 2

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    Regina Maria Fernandes Lopes

    2009-01-01

    Full Text Available El avance en las condiciones de salud propicia el progresivo aumento de la esperanza de vida. Estudios han identificado la existencia de una conexión entre la Diabetes Mellitus (DM y demencia. La hiperglicemia podría ser un factor importante en la incidencia de la enfermedad de Azheimer, la cual puede ser una causa secundaria de demencia. La diabetes mellitus tipo 2 (DM2 está asociada con déficits cognitivos y funcionales, y el WCST es una de las herramientas que puede ser utilizada para evaluar funcionamiento ejecutivo. El objetivo de este estudio fue evaluar los déficits cognitivos de ancianos con diabetes mellitus tipo 2. Los participantes fueron 254 ancianos de ambos sexos, mayores de 60 años; 44 de ellos diagnosticados de DM2 y 210 en un grupo control de población general. El diseño fue un estudio cuantitativo transversal. Los instrumentos utilizados fueron: datos sociodemográficos, WCST, MMSE, BDI, BAI, GD, junto a las Sub pruebas de: Vocabulario, códigos, números y Cubos del WAIS-III. Los resultados mostraron una diferencia significativa en el desempeño de los ancianos con diabetes tipo 2 en comparación con el grupo control en cuatro descriptores de WCST que indicaban un deterioro. Igualmente los ancianos con diabetes tipo 2 mostraron una intensidad de síntomas depresivos y de ansiedad estadísticamente mayor que el grupo control

  5. Factores de riesgo de enfermedad aterosclerótica en la diabetes mellitus tipo 2

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    Socarrás Suárez, María Matilde; Blanco Anesto, Jorge; Vázquez Vigoa, Alfredo; González Hernández, Daris; Licea Puig, Manuel E.

    2003-01-01

    Se realizó un estudio descriptivo de corte transversal a 199 pacientes con diagnóstico de diabetes mellitus tipo 2, para conocer la frecuencia de obesidad, describir hábitos dietéticos y determinar si existe asociación entre obesidad y presencia de factores de riesgo cardiovasculares como hipertensión arterial, dislipidemia, hiperinsulinemia, hábito de fumar, microalbuminuria y antecedentes familiares de primera línea de obesidad. Para el análisis comparativo de las variables continuas entre ...

  6. MHEALTH Y TICS EN LOS CUIDADOS DE LA DIABETES MELLITUS TIPO 1

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    Ramos Fernández, Javier

    2017-01-01

    La diabetes mellitus tipo 1 es una enfermedad crónica consistente en un cuadro metabólico caracterizado por hiperglucemia mantenida, provocada por un déficit absoluto de insulina y por lo tanto, es necesaria su administración exógena; Constituye el 10% de los casos de diabetes en la población general, y se da en niños y adolescentes con gran diferencia (95%) 1. Debido a que es una enfermedad crónica, debemos realizar una educación precoz y profunda sobre los hábitos de vida de las personas di...

  7. Consumo de Café e o Risco de Desenvolver Diabetes Mellitus tipo 2

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    Ferreira, Diana Isabel Gomes

    2015-01-01

    A diabetes mellitus tipo 2 é uma doença crónica, que está associada a altas taxas de morbidade e mortalidade prematura. O aumento da indicência desta patologia, muito em parte pelos actuais estilos de vida adoptados, tem levado ao interesse do estudo da DM2. O consumo regular de café tem vindo a ser associado de forma positiva com a DM2 e por ser umas das bebidas mais consumidas na actualidade, leva a uma crescente preocupação em conhecer os seus benefícios e malefícios, desencadeando o in...

  8. Síndrome de Mauriac: forma rara do diabetes mellitus tipo 1

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    Maia, Frederico F.R.; Araújo, Levimar R.

    2002-01-01

    O diabetes mellitus tipo 1 (DM1) é uma das doenças endócrino-metabólicas mais importantes na faixa etária pediátrica, podendo se manifestar com alterações sistêmicas decorrentes do controle glicêmico inadequado, como hepatomegalia e déficit de crescimento. Apresentamos o caso de uma criança com DM1 descompensado, evoluindo com sinais clínicos e laboratoriais sugestivos de síndrome de Mauriac. Alertamos para a importância do conhecimento dessa forma rara de DM1, buscando orientar e esclarecer ...

  9. Asociación entre psoriasis y el control de diabetes mellitus tipo 2

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    García Montañez, María Andrea

    2014-01-01

    La psoriasis es una enfermedad que se caracteriza por un proceso inflamatorio crónico y exagerado local y sistémico. Se ha encontrado en la literatura una relación entre la psoriasis y el desarrollo de patologías como diabetes mellitus tipo 2 y el mal control de estas patologías, lo cual aumenta la morbimortalidad de estos pacientes. El presente estudio mostró que no se encontró asociación entre psoriasis y el control de la DM2 , y que la variable mas significativa sobre el control es la ad...

  10. Adolescentes com Diabetes Mellitus Tipo 1: Estresse, enfrentamento e adesão ao tratamento

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    Victório, Vanessa Marques Gibran

    2016-01-01

    O Diabetes Mellitus Tipo 1 (DM1) é uma condição crônica de saúde caracterizada pelo excesso de glicose no sangue e produção deficiente de insulina pelo pâncreas, exigindo a ingestão diária de insulina para o controle metabólico. Este é afetado por variáveis psicossociais, especialmente durante a adolescência, que é uma fase de risco para reações de estresse. A forma como o adolescente lida com o estresse depende, em parte, de seu repertório de enfrentamento. As estratégias de enfrentamento [E...

  11. El polimorfismo (CAGn del gen ATXN2, nuevo marcador de susceptibilidad para diabetes mellitus tipo 2

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    Luis J. Flores-Alvarado

    Full Text Available RESUMEN Objetivo Estimar si hay asociación del repetido (CAGn del gen ATXN2 en población mexicana con diabetes mellitus (DM tipo 2. Métodos Estudio epidemiológico de casos y controles. Se incluyeron personas sanas y personas diabéticas. La detección de la expansión (CAGn se realizó por reacción en cadena de la polimerasa (PCR-punto final. Los productos de PCR se analizaron mediante electroforesis (PAGE al 8% y tinción con nitrato de plata. Resultados La distribución de alelos del trinucleótido (CAGn en la población analizada resultó similar a la reportada en el centro del país. El alelo más frecuente es el de 22 repetidos; sin embargo, hay asociación con los portadores de los repetidos largos dentro del rango normal con diabetes. Conclusiones Los resultados sugieren que el repetido (CAGn del gen de ATXN2 podría ser un factor causal de DM tipo 2.

  12. Adesão de pessoas com diabetes mellitus tipo 2 ao tratamento medicamentoso

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    Lilian Cristiane Gomes-Villas Boas

    2014-04-01

    Full Text Available Estudo seccional de abordagem quantitativa que objetivou avaliar a adesão ao tratamento medicamentoso entre pessoas com diabetes mellitus, e sua relação com variáveis clínicas, de tratamento e controle metabólico. A amostra constituiu-se de 162 pessoas com diabetes mellitus tipo 2 em seguimento ambulatorial. Para a coleta dos dados, foram utilizadas a Medida de Adesão aos Tratamentos e a consulta aos prontuários dos participantes. Obteve-se elevada adesão ao tratamento medicamentoso. Para um p<0,05, obteve-se correlação inversa com a pressão arterial diastólica e correlação direta com a frequência diária de administração de insulina e de antidiabéticos orais. Não houve correlações estatisticamente significantes entre adesão e variáveis de controle metabólico. Os resultados divergem da literatura no que se refere à taxa de adesão ao tratamento medicamentoso em doenças crônicas, bem como na correlação entre adesão e complexidade do regime medicamentoso, o que aponta para a necessidade de mais estudos sobre essa temática.

  13. Reação de resistência tipo I e tipo II a Giberela em cultivares de trigo

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    Rafael Hansen Alves

    2013-09-01

    Full Text Available O objetivo deste trabalho foi avaliar as reações de resistência tipo I e tipo II à giberela em 28 cultivares de trigo em casa de vegetação. A inoculação de Fusarium graminearum foi realizada no estádio de florescimento. Para a resistência tipo I, a avaliação foi feita 21 dias após a inoculação. Foi determinada a severidade no estádio de espiga seca e a porcentagem de grãos giberelados. A avaliação da severidade foi feita pela porcentagem de espiguetas infectadas, no estádio de espiga verde atribuindo-se uma nota em uma escala linear de zero (nenhuma infecção a 100 (100% de espiguetas infectadas. Para a resistência tipo II, as avaliações foram realizadas aos 7, 14 e 21 dias após a inoculação, contando-se as espiguetas com sintomas da doença, excluindo as duas espiguetas que foram inoculadas. As cultivares Frontana, BRS 177, BRS 179, BRS Umbu, BRS Camboim, Abalone, Ônix, Pampeano e Fundacep 30 apresentaram menor severidade da doença e menor porcentagem de grãos giberelados, demonstrando serem fontes de resistência tipo I. As cultivares BRS Guamirim, CD 120, Onix, Rubi, Fundacep 50, BRS 179, Pampeano, Abalone, CD 114, IPR 85, Safira, BRS Louro, CD 117, CDF 2002116, CD 115, BRS 177, CD 0529 e BRS Camboim apresentaram a menor área abaixo da curva de progresso da doença, demonstrando a presença da resistência do tipo II.

  14. Fatores imunogenéticos associados ao diabetes mellitus do tipo 1 Factores inmunogenéticos asociados a la diabetes mellitus tipo 1 Immunogenetic factors associated with type 1 diabetes mellitus

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    Ana Paula Morais Fernandes

    2005-10-01

    Full Text Available O diabetes mellitus do tipo 1 tem sido considerado uma doença auto-imune órgão-específica, decorrente da destruição seletiva das células betapancreáticas. Apresenta patogenia complexa, envolvendo a participação de vários fatores, dentre esses a susceptibilidade imunogenética com forte associação aos genes de histocompatibilidade (HLA, eventos ambientais e resposta auto-imune com presença de auto-anticorpos e/ou linfócitos auto-reativos, culminando em anormalidades metabólicas. Neste estudo, a revisão da literatura descreve os mecanismos pelos quais determinados fatores conferem susceptibilidade para o seu desencadeamento e, adicionalmente, as inovações na predição dessa desordem que, certamente, contribuirão para a assistência de enfermagem aos pacientes portadores do diabetes tipo 1.La Diabetes Mellitus tipo 1 ha sido considerada una enfermedad autoinmune órgano-específica debido a la destrucción selectiva de las células beta pancreáticas. Presenta una patogenia compleja, involucrando la participación de varios factores, entre esos la susceptibilidad inmunogenética con fuerte asociación a los genes de histocompatibilidad (HLA, eventos ambientales y respuesta autoinmune con presencia de auto-anticuerpos y/o linfocitos auto-reactivos, culminando en anormalidades metabólicas. En este estudio, la revisión de la literatura describe los mecanismos por los cuales determinados factores resultan en susceptibilidad para su desarrollo y, adicionalmente, las innovaciones en la predicción de ese desorden que, por cierto, van a contribuir para la atención de enfermería a los pacientes portadores de la diabetes tipo 1.Type 1 diabetes mellitus has been considered an organ-specific autoimmune disease derived from the selective destruction of pancreatic beta cells. It presents a complex pathogenesis, involving the participation of several factors, including the immunogenetic susceptibility with strong association to

  15. El Enigma de las Causas de la Diabetes Mellitus Tipo 2 El Enigma de las Causas de la Diabetes Mellitus Tipo 2

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    Juan Manuel Malacara

    2012-02-01

    Full Text Available Type 2 diabetes mellitus the most frequent metabolic disease, is induced by factors so far largely unknown. Genetic and environmental causes are implicated, among the latter obesity and sedentary life are the most important. The discovery of new hormones controlling food intake such as leptin, ghrelin and the YY3-36 peptide, are expected to provide new tools to reduce overfeeding. The genes associated with type 2 diabetes are intensively sought without success.It is possible that the genetic transmission is more complex than suppossed. The theory of the thrifty gene proposes an explanation for the increased obesity and diabetes in ethnic groups in transition from preindustrial to industrialized cultures. The theory of the fetal origins of adult disease, proposes that in the fetal life there is a window for metabolic programming under stress or caloric restriction. If the subject, however, at the adult life consumes excessive caloric intake, has a high risk for the metabolic syndrome. The mechanisms involved in insulin resistance are complex, and several molecules are under study as candidates to explain it. The diminution in insulin secretion is an other important factor for the initiation of type 2 diabetes. Glucotoxicity and lipotoxicity are factors that further reduce insulin secretion. Recent evidence indicates that inflammation is implicated in the onset of both diabetes and atherosclerosis. The elucidation of the nature of this process, as well as the pathways involved will be another important tool for a better management of this disease.La causa de la diabetes mellitus tipo 2, la enfermedad metabólica más frecuente, no es bien conocida. Tiene un componente genético y otro ambiental, en éste destacan la obesidad y el sedentarismo. El conocimiento de las nuevas hormonas que controlan la alimentación: la leptina, la ghrelina y el péptido YY3-36, es una esperanza para el control de la obesidad. No se han identificado los genes

  16. Adherencia al tratamiento nutricional en pacientes con diabetes mellitus tipo 2 que asisten a un programa educativo

    OpenAIRE

    Mariela A. Carvajal

    2017-01-01

    El objetivo de este estudió fue evaluar la adherencia al tratamiento nutricional por medio de la hemoglobina glicosilada en pacientes con diabetes mellitus tipo 2 que asistieron a un programa educativo en diabetes en la ciudad de Guatemala, así como evaluar los principales factores que influyen en ella. Se realizó un estudio de tipo prospectivo, longitudinal, experimental, pareado de intervención no medicamentosa. Se utilizó la prueba de Morinsky-Green Levine para evaluar la adherencia al tra...

  17. Estilo de vida actual de los pacientes con diabetes mellitus tipo 2

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    María Mercedes Ramírez-Ordoñez

    2011-12-01

    Full Text Available Se realizó un estudio descriptivo transversal con el objetivo principal de determinar el estilo de vida actual de los pacientes con diabetes mellitus tipo 2. Para la recolección de la información se utilizó el cuestionario IMEVID1. La población está conformada por 60 pacientes inscritos al programa de diabetes e hipertensión de una Institución Promotora de Salud (IPS de I nivel; como muestra se tuvo en cuenta 30 pacientes que asistieron sin falta al control de la diabetes a los cuales se les aplicó el instrumento. Las variables utilizadas son nutrición, actividad física, consumo de tabaco, consumo de alcohol, información sobre la diabetes, emociones, adherencia terapéutica y estilos de vida. Se concluye que con relación a la edad de los pacientes encuestados se obtiene que estos se encuentran entre dos etapas muy importantes del ciclo vital humano, adultez media y adultez tardía; el 80% de los pacientes encuestados presentaron prácticas de estilos de vida saludables, el cual ayuda a prevenir complicaciones con relación a su patología obteniendo de esta manera un mejor bienestar durante su vida y la evolución de la enfermedad.

  18. SINTOMAS DEPRESSIVOS E ADESÃO AO TRATAMENTO ENTRE PESSOAS COM DIABETES MELLITUS TIPO 2

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    Juciene de Matos Braz

    2012-01-01

    Full Text Available El objetivo fue investigar la asociación entre síntomas depresivos y variables sociodemográficas y clínicas, así como la adhesión al tratamiento medicamentoso en personas con diabetes mellitus tipo 2 (DM2. Estudio descriptivo, desarrollado con muestra constituida por 145 portadores de DM2. Fue utilizado el Inventario de Depresión de Beck (BDI y la Medida de Adhesión a los Tratamientos (MAT. La edad media de los participantes fue de 60,4 años, 77,2% eran mujeres y 51,7% poseían compañero(a. La media del BDI fue de 18,4; y 33,1% de los sujetos presentaron síntomas depresivos. La práctica de actividad física se asoció a una mejor evaluación en el BDI ( p< 0,05. No fue observada correlación clínicamente importante entre BDI y MAT (r<0,30. Aproximadamente mitad de los participantes presentó tendencia a desarrollar la depresión. La práctica de actividad física fue asociada a una mejor evaluación en el BDI.

  19. Qualidade de vida relacionada à saúde de pessoas com diabetes mellitus tipo 2

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    Loisláyne Barros Leal

    2014-01-01

    Full Text Available El objetivo fue evaluar la Calidad de Vida Relacionada a la Salud de personas con Diabetes Mellitus tipo 2. Investigación transversal, realizada con 100 diabéticos. La recolección de datos se llevó a cabo entre marzo y abril de 2012, en dos equipos de la Estrategia Salud de la Familia de Picos, PI, Brasil, a través de entrevista individual. Se aplicó formulario con variables socioeconómicas, clínicas y el Medical Outcomes Study 36 – Item Short Form Health Survey (SF-36. El promedio entre los componentes del SF-36 osciló de 34,8 (Aspectos físicos a 72,0 (Salud mental. Hubo asociación estadísticamente significativa del dolor y la capacidad funcional con el sexo, así como de la capacidad funcional y los aspectos emocionales con la actividad física (p <0,05. En conclusión, los participantes presentaron mejor evaluación en la calidad de vida en las dimensiones que integran el componente mental.

  20. Epidemia de Diabetes Mellitus Tipo 2 en Latinoamérica

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    Patricio López-Jaramillo

    2010-12-01

    Full Text Available

    Introducción: Los países latinoamericanos presentan un crecimiento acelerado de la prevalencia de DM2 por la asociación de determinados condicionantes. La cabal comprensión de estos condicionantes es fundamental para combatir la epidemia de DM2 en Latinoamérica, entendiendo que un programa eficaz de prevención de esta patología demanda un esfuerzo concertado de todos los actores de la sociedad, y no solo del equipo de salud.

    Objetivos: Con el fin de detectar algunos condicionantes que posiblemente están asociados a la epidemia de DM2 en Latinoamérica, se revisaron trabajos incluidos principalmente en la base de datos de PubMed; se incluyeron investigaciones de los últimos cinco años, realizadas en el país y la región o en países receptores de migrantes latinoamericanos.

    Resultados: La Diabetes Mellitus tipo 2 (DM2 está asociada al incremento en las tasas de obesidad y sobrepeso, producto de la rápida urbanización experimentada en los últimos años, la cual determina cambios en actividad física y hábitos dietéticos. Además, la programación fetal de hijos de madres mal nutridas durante la gestación, determina una mayor sensibilidad de estos niños con bajo peso al nacer para desarrollar resistencia a la insulina e inflamación de bajo grado, especialmente cuando se ven sometidos a un medio de excesos alimentarios (a menudo de “comida chatarra” para los cuales no estuvieron programados, lo que les lleva a presentar obesidad abdominal y mayor riesgo de DM2.

    Discusión: Los condicionantes de la presencia de DM2 en Latinoamérica se relacionan con un desarrollo socio-económico anormal, pues básicamente responden a la contradicción entre la necesidad de adaptación del feto a una alimentación materna defi ciente o a una insuficiencia placentaria producto de enfermedades como la preclampsia; y en la etapa adulta, el modo de vida

  1. Diabetes mellitus tipo 1: posible relación con la interrupción precoz de la lactancia materna

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    Dalila Teixeira Leal

    2012-12-01

    Full Text Available Introducción: La dieta es importante en la patogénesis de la diabetes tipo 1, los estudios indican una fuerte asociación entre la exposición temprana a la leche de vaca y la aparición de esta enfermedad. Objetivo: Verificar la existencia de la relación entre el destete precoz de la lactancia materna, la exposición a otras leches antes de seis meses de vida y el desarrollo de diabetes mellitus tipo 1. Materiales y Métodos: Investigación cuantitativa, a los padres respecto a los niños y adolescentes con diabetes tipo 1 que se registraron en el Departamento de Control de la Presión Arterial, Diabetes y Obesidad del Departamento Municipal de Salud de Juiz de Fora com una muestra total de 89 participantes. El instrumento utilizado para la recolección de datos fue un cuestionario estructurado aplicado a estos padres, los sujetos de la investigación fueron de ambos sexos y de todas las razas. Cabe señalar que el origen de esta investigación son los usuarios de los servicios de Diabetes Mellitus tipo 1, pero sólo los padres o tutores fueron entrevistados.Resultados: Se presentan datos sobre la caracterización de la muestra, la aparición o no de destete precoz de la lactancia materna, período de la lactancia materna exclusiva, si se ofreció dieta después del destete y las razones que llevaron a esta ocurrencia. Discusión y Conclusiones: La relación entre el destete precoz de la lactancia materna, con la consiguiente introducción de sustitutos de la leche materna, podría conllevar al desarrollo de diabetes mellitus tipo 1. (Rev Cuid 2012;3(3:293-9.Palabras clave: Diabetes Mellitus Tipo 1. Lactancia Materna. Enfermería. (Fuente: DeCS BIREME.

  2. Risk factors in patients with type 2 diabetes mellitus Factores de riesgo en pacientes con diabetes mellitus tipo 2 Fatores de risco em pacientes com diabetes mellitus tipo 2

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    Idalina Diair Regla Carolino

    2008-04-01

    Full Text Available This study was carried out to evaluate the risk factors of type 2 diabetic patients through sociodemographic data, habits of health, anthropometric and biochemist profiles, assisted at a basic public health care unit in Maringá, Paraná. Sixty-six patients, 56 women aged over than 50 years-old were interviewed. High prevalence factors for cardiovascular risk were observed, such as: overweight and obesity, hypertension, dyslipidemia, sedentariness and inadequate diet. Data suggested the need for multidisciplinary intervention programs in health care units associated to educative programs, adjusted diet intake and regular physical activity for these diabetic patients.El objetivo de este estudio fue verificar los factores de riesgo de las complicaciones de la diabetes mellitus tipo 2, por medio del levantamiento de datos sociodemográficos, hábitos de salud, perfil antropométrico y bioquímico, de pacientes diabéticos tipo 2 atendidos en una Unidad Básica de Salud en la ciudad de Maringá, Paraná. Fueron entrevistados y evaluados 66 pacientes con más de 50 años; 56 eran del sexo femenino. Se verificó una elevada presencia de factores de riesgo cardiovascular en los pacientes investigados: sobrepeso y obesidad, hipertensión, dislipidemia, sedentarismo y dieta no saludable. Los resultados indican la necesidad de la implantación de programas de intervención multidisciplinares en unidades básicas de la salud asociada a prácticas educativas, estimulando la adopción de una dieta saludable y la práctica de actividad física regular para estos pacientes.O objetivo deste estudo foi verificar os fatores de risco das complicações do diabetes mellitus tipo 2, por meio de levantamento de dados sociodemográficos, hábitos de saúde, perfil antropométrico e bioquímico de pacientes diabéticos tipo 2, atendidos em Unidade Básica de Saúde, na cidade de Maringá, Paraná. Foram entrevistados e avaliados 66 pacientes acima de 50 anos, sendo 56

  3. Caracterização de pessoas com Diabetes Mellitus Tipo 2 Caracterización de personas con Diabetes Mellitus Tipo 2 Characterization of people with Diabetes Mellitus Type 2

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    Maria de Fátima Ferreira Grillo

    2007-02-01

    Full Text Available O estudo teve por objetivo caracterizar pessoas com Diabete Melittus (DM Tipo 2, cadastrados em uma Unidade Básica de Saúde. É um estudo observacional, descritivo, do tipo série de casos, com uma amostra de 125 pessoas. Os resultados apresentaram, em sua maioria, pessoas do sexo feminino, na faixa etária dos 60 aos 69 anos e que recebiam de 1 a 2 salários mínimos por mês, hipertensos, dislipidêmicos, com sobrepeso e/ou obesidade, não praticando atividade física regularmente, com dificuldade em seguir a dieta e em conviver com a doença. Concluiu-se a importância de planejar Programas de Atenção à Saúde voltada para pessoas diabéticas, no contexto comunitário, com o incentivo da Educação em saúde por meio de uma equipe multidisciplinar.El estudio tiene por objetivo caracterizar personas con Diabetes Mellitus (DM Tipo 2, inscriptos en una Unidad Básica de Salud. Es un estudio de observación, descriptivo, de tipo serie de casos, con una muestra de 125 personas. Los resultados presentaron, en su mayoría, personas de sexo femenino, en la faja etaria de los 60 a los 69 años y que recibían de 1 a 2 sueldos mínimos por mes, hipertensos, dislipidémicos, con sobrepeso y/u obesidad, no practicando actividad física regularmente, con dificultades en seguir la dieta y en convivir con la enfermedad. Se concluye la importancia de planear Programas de Atención a la Salud volcada para personas diabéticas, en el contexto comunitario, con el incentivo de la Educación en salud por medio de un equipo multidisciplinar.This study has as its main objective the characterization of people with Diabetes Mellitus (DM Type 2 who were registered in a Basic Health Unit. It is an observational, descriptive study with a sample of 125 people. The results presented, in most part, female people, between their 60 and 69 years old who receive from 1 to 2 minimum salary per month, hypertensive, dyslipidemic, overweight and/or obese, people who do not

  4. Algunas consideraciones sobre la hipertensión arterial en la diabetes mellitus tipo 2 Some considerations related to arterial high blood pressure in Type 2 diabetes mellitus

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    Miguel Ángel Yanes Quesada

    2009-09-01

    Full Text Available Se realizó una revisión del tema relacionado con la hipertensión arterial en el paciente diabético tipo 2, con el objetivo de actualizar algunos elementos particulares en este grupo de pacientes. Se plantea que su prevalencia es considerablemente más alta que en la población no diabética, donde la hiperinsulinemia y la disfunción endotelial cobran un papel protagónico en su etiopatogenia. La hipertensión arterial en estos pacientes clínicamente se manifiesta como un patrón non dipper, lo que incrementa la morbimortalidad por esta entidad. El tratamiento medicamentoso es habitualmente necesario, y se usan como drogas de primera línea los inhibidores de la enzima convertidora, los antagonistas de los receptores de angiotensina ll y los calcioantagonistas, aunque se pueden utilizar también los diuréticos tiacídicos a dosis bajas.Authors made a review of the topic related to arterial high blood pressure in the patient presenting with Type 2 diabetes mellitus to update some particular elements in this group of patients. We propose that its prevalence is higher than that present in non-diabetic population, where the hyperinsulinism and the endothelial dysfunction have a leading role in its ethiopathogenesis. The arterial high blood pressure in these patients clinically is manifested as a non-dipper pattern increasing the morbidity and mortality. Drug therapy is commonly necessary and as first line-drugs are used the converting-enzyme inhibitors, the agiotensin-II receptors antagonists, and the antagonists-calcium, although the low-dose thiacidic diuretics.

  5. Ejercicio de resistencia muscular en adultos con diabetes mellitus tipo 2 Exercício de resistência muscular em adultos com diabetes mellitus tipo 2 Endurance training in adults with diabetes mellitus type 2

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    Karina Asunción Muñoz Canché

    2005-02-01

    Full Text Available Objetivos. Probar la efectividad del ejercicio de resistencia muscular en las cifras de hemoglobina glucosilada (HbA1c, en la fuerza muscular y en la fortaleza muscular percibida; explorar la influencia de la dieta, otros ejercicios, hipoglucemiantes y manifestaciones asociadas a episodios de hipoglucemia o hiperglucemia sobre el control glucémico de adultos con diabetes mellitus tipo 2 provenientes de los consultorios de endocrinología de dos hospitales públicos de la Ciudad de Monterrey, México. Procedimientos básicos. Se usó un diseño de 12 semanas de grupo control no equivalente con dos grupos, experimental (n1 = 14 y control (n2 = 11. Los participantes contaron con la recomendación de su médico para participar. Las sesiones de ejercicio fueron de una hora, dos veces por semana. Resultados. El grupo experimental mostró decremento significativo en el porcentaje de HbA1c, e incremento en la fuerza muscular y fortaleza muscular percibida (p Objetivos: Provar a efetividade do exercício de resistência muscular nas taxas de hemoglobina A glicosilada (HbA1c, na força muscular e no fortalecimento muscular percebido, explorar a influência da dieta, outros exercícios, hipoglicemiantes e manifestações associadas a episódios de hipoglicemia ou hiperglicemia sobre o controle glicêmico de adultos com diabetes mellitus tipo 2, provenientes dos consultórios de endocrinologia de dois hospitales públicos da Cidade de Monterrey, México. Procedimentos básicos: Foi utilizado um desenho de 12 semanas de grupo controle não equivalente com dois grupos, experimental (n1=14 e controle (n2=11. Os participantes tiveram recomendação de seu médico para participar. As sessões de exercício foram de uma hora, duas vezes por semana. Resultados: O grupo experimental apresentou decréscimo significativo nas taxas de HbA1c, incremento na força muscular e fortalecimento muscular percebido (pObjectives. Test the effects of an endurance training

  6. Avaliação funcional dos pés de portadoresde diabetes tipo II

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    Vinicius Saura Cardoso

    2013-12-01

    Full Text Available Objetivo: Avaliar a ocorrência de alterações funcionais e o risco de desenvolver úlceras nos pacientes diabéticos tipo II atendidos em Unidades Básicas de Saúde (UBS. Métodos: Realizou-se estudo transversal, quantitativo e descritivo com 80 portadores de diabetes mellitus (DM tipo II que apresentavam idade entre 41 e 85 anos e frequentavam as UBS do município de Parnaíba-PI. Os voluntários responderam ao questionário de identificação e ao Michigan Neuropathy Screening Instrument (MNSI, seguido da avaliação dos membros inferiores, sendo: reflexos aquileu e patelar; palpação dos pulsos arteriais (tibial posterior e pedioso; sensibilidade tátil (monofilamento 10g e vibratória (diapasão 128 Hz; identificação da presença de alterações como unha encravada, calosidades, dedos em garra e queda de pelos. Por fim, utilizando as informações adquiridas na avaliação, os voluntários foram classificados quanto ao risco de desenvolver feridas. Resultados: A amostra foi composta por 76 diabéticos, com média de idade de 63,8±10,4 anos, sendo 63 (82,8% do sexo feminino, com média de tempo de diagnóstico de 8,8±7,2 anos, média do índice de massa corpórea (IMC de 28,2±5,4 Kg/m2, sendo 15,7% da amostra fumantes. Os reflexos miotáticos e pulsos arteriais apresentaram-se hiporreflexos e diminuídos, respectivamente. A sensibilidade tátil foi identificada em 81,5%, e 13,1% não sentiram a vibração do diapasão. A calosidade foi a alteração mais prevalente em 76,3% (n=58. O risco 2 de desenvolver úlceras se sobressaiu, 52,6% (n=40. Conclusão: Observaram-se alterações funcionais na amostra estudada e uma classificação de risco 2 para desenvolvimento de feridas em mais de 50% dos avaliados.

  7. Caracterización del inicio de la diabetes mellitus tipo 1 en menores de 18 años

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    Yan González Ramos

    2016-12-01

    Full Text Available Fundamento: la diabetes mellitus tipo 1 es la enfermedad crónico endocrinológica más frecuente en la edad pediátrica y la segunda enfermedad crónica en la infancia después del asma bronquial, en los países desarrollados. Objetivo: identificar los aspectos epidemiológicos en el inicio de la diabetes mellitus tipo 1 en menores de 18 años en la provincia de Cienfuegos en el periodo 1997- octubre 2015. Métodos: se realizó un estudio descriptivo retrospectivo en los pacientes menores de 18 años, diagnosticados con diabetes mellitus tipo 1 en el periodo mencionado. Las variables utilizadas fueron: año y edad del inicio, sexo, color de la piel y municipio de procedencia. Los resultados se presentaron en tablas de frecuencias y porcentajes. Resultados: el porcentaje de pacientes del sexo masculino y femenino fue bastante similar con un leve predominio del masculino (53,5 %. El grupo 5-9 años presentó el mayor número de pacientes (35 casos pero sin diferencias significativas con el de 10-14 años (34 casos. El color de piel blanca predominó con el 75,7 %. El mayor número de casos se mostraron en los meses de otoño con 30. Los municipios de mayor incidencia fueron Cienfuegos con 40 y Cumanayagua con 16 casos respectivamente. Conclusiones: se ha producido un aumento de la incidencia en los últimos años con un leve predominio del sexo masculino y el grupo de 5-9 años. Predominó la raza blanca. El mayor número del inicio ocurrió en otoño y en el municipio de Cienfuegos.

  8. Educación para la salud en el niño que debuta con Diabetes mellitus tipo 1

    OpenAIRE

    Fernandez Ortiz, Jose Antonio

    2016-01-01

    La diabetes mellitus tipo 1 (DM1) es una enfermedad crónica producida en el páncreas por la ausencia de insulina debido a un origen autoinmune, suele debutar en la infancia y su incidencia sigue aumentando. Los cuidados derivados de información escasa o incorrecta suponen graves problemas de salud. La educación sanitaria en pacientes diabéticos debe proporcionar las herramientas necesarias y así alcanzar unos conocimientos adecuados para el autocuidado de esta enfermedad. Grado en Enfermer...

  9. Adaptación en pacientes con diabetes Mellitus Tipo 2, según Modelo de Roy

    OpenAIRE

    Margarita Lazcano-Ortiz; Bertha Cecilia Salazar-González

    2009-01-01

    Objetivo. Determinar la influencia entre estímulos focales y contextuales, y la adaptación fisiológica y psicosocial en personas con diabetes Mellitus Tipo 2 (DMT2). Material y método. El diseño fue descriptivo, transversal, predictivo. El muestreo fue probabilístico, sistemático. La muestra con 200 participantes de ambos géneros de 30 a 65 años, se determinó para un 95% de confianza, con una potencia de prueba de 90%. Resultados. Los resultados mostraron que el tiempo desde diagnóstico expli...

  10. Aspectos más recientes en relación con la diabetes mellitus tipo MODY Most recent aspects about type MODY diabetes mellitus

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    Ana Ibis Conesa González

    2012-08-01

    Full Text Available Antecedentes: la mejor comprensión fisiopatológica de la diabetes mellitus permite identificar diferentes tipos, entre ellos una variante monogénica denominada por sus siglas en inglés MODY (Maturity-Onset Diabetes of the Young. Objetivos: describir los aspectos fisiopatológicos, clínicos, diagnósticos y terapéuticos de los diferentes subtipos MODY. Desarrollo: los pacientes con diabetes tipo MODY presentan un comportamiento similar a la diabetes mellitus del adulto. Se caracteriza por una alteración genética autosómica dominante inherente y primaria a un defecto en la secreción de insulina. Hasta el momento actual se aceptan 9 subtipos de MODY. Los subtipos 1, 3, 4, 5 y 6 afectan a genes que codifican a factores nucleares de trascripción, y el subtipo 2 al gen que codifica a la enzima glucoquinasa. Se caracterizan clínicamente por cuadros que oscilan entre hiperglucemias permanentes, leves o moderadas, con buen pronóstico clínico, y pocas complicaciones, hasta cuadros de hiperglucemias mantenidas acompañadas de complicaciones crónicas precoces y graves. Conclusiones: las personas que padecen diabetes tipo MODY no son tan infrecuentes como se piensa. La correcta y temprana identificación de la enfermedad permitirá una acción terapéutica más racional y adecuada para brindar la posibilidad de mejor calidad de vida de estas personas.Background: a better physiopathological understanding of diabetes mellitus allows identifying its different types such as a monogenic variant called MODY (maturity-onset diabetes of the young. Objectives: to describe the physiopathological, clinical, diagnostic and therapeutic aspects of the different subtypes in MODY diabetes. Development: the patients with MODY diabetes behave similarly to those suffering diabetes mellitus in adults. It is characterized by inherited dominant autosomal genetic alteration which is primary to a defect in insulin secretion. Up to the present, 9 subtypes are accepted

  11. Crecimiento y desarrollo de niños y jóvenes con diabetes mellitus tipo 1

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    Enrique Rotemberg Wilf

    Full Text Available Resumen La diabetes mellitus es un síndrome metabólico que se caracteriza por hiperglucemia con alteración en el metabolismo de los carbohidratos, proteínas y grasas, causada por deficiencias en la producción o en la utilización de la insulina. Es la enfermedad endocrinometabólica más frecuente de la infancia y adolescencia. La diabetes tipo 1 es una condición crónica debido a la destrucción de las células beta de los islotes de Langerhans del páncreas por enfermedad autoinmune o sin causa conocida. El crecimiento y desarrollo general y cráneo facial del individuo van a estar influenciados por distintos factores que actúan interrelacionados. Los profesionales de la salud deben controlar la evolución del niño con diabetes 1 especialmente durante la pubertad. Es probable encontrar diferencias de crecimiento y desarrollo entre jóvenes con eficaz o con pobre control glucémico, en especial si la enfermedad es de inicio prepuberal y si es o no diagnosticada en forma precoz. La diabetes mellitus tipo 1 puede afectar la salud buco-dental de niños y adolescentes, con posibles consecuencias en la vida adulta

  12. Adaptación en pacientes con diabetes Mellitus Tipo 2, según Modelo de Roy

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    Margarita Lazcano-Ortiz

    2009-01-01

    Full Text Available Objetivo. Determinar la influencia entre estímulos focales y contextuales, y la adaptación fisiológica y psicosocial en personas con diabetes Mellitus Tipo 2 (DMT2. Material y método. El diseño fue descriptivo, transversal, predictivo. El muestreo fue probabilístico, sistemático. La muestra con 200 participantes de ambos géneros de 30 a 65 años, se determinó para un 95% de confianza, con una potencia de prueba de 90%. Resultados. Los resultados mostraron que el tiempo desde diagnóstico explicó la adaptación fisiológica F (1,198 = 9,18, p = ,003. Se observó efecto entre complicaciones y adaptación psicosocial F (4,195 = 4,97, p = ,001, con un coeficiente de determinación del 74%. Los estímulos contextuales influyeron en la adaptación fisiológica y psicosocial, F (6,193 = 2,89, p = ,010, y F (6, 193 = 2,41, p = ,029. Conclusiones. Los resultados de este estudio permiten sugerir relaciones entre las proposiciones teóricas propuestas y derivadas del Modelo de Adaptación de Roy, particularmente entre los estímulos y la adaptación fisiológica y psicosocial en pacientes con diabetes Mellitus Tipo 2.

  13. Serum markers for type II diabetes mellitus

    Science.gov (United States)

    Metz, Thomas O; Qian, Wei-Jun; Jacobs, Jon M; Polpitiya, Ashoka D; Camp, II, David G; Smith, Richard D

    2014-03-18

    A method for identifying persons with increased risk of developing type 2 diabetes mellitus utilizing selected biomarkers described hereafter either alone or in combination. The present invention allows for broad based, reliable, screening of large population bases and provides other advantages, including the formulation of effective strategies for characterizing, archiving, and contrasting data from multiple sample types under varying conditions.

  14. Uso de neumocitos de tipo II en el tratamiento de enfermedades pulmonares asociadas con fibrosis pulmonar

    OpenAIRE

    Serrano-Mollar, Anna; Closa, Daniel; Bulbena, Oriol

    2005-01-01

    Se describe el empleo de neumocitos tipo II como agentes inhibidores de la proliferación de fibroblastos, por lo que pueden ser utilizados en la elaboración de un medicamento para el tratamientode enfermedades pulmonares que cursan con fibrosis pulmonar.

  15. Calidad del hueso en mujeres de edad mediana con diabetes mellitus tipo 2 Bone quality in middle-aged females with type 2 diabetes mellitus

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    Alina Acosta Cedeño

    2008-04-01

    Full Text Available ANTECEDENTES: la osteoporosis y diabetes mellitus constituyen problemas de salud para la población senescente en general y para la mujer en particular. El descontrol metabólico y las lesiones microvasculares de la DM afectan todo el organismo, incluyendo el hueso. OBJETIVO: determinar la calidad del hueso en mujeres de edad mediana con diabetes mellitus tipo 2. MÉTODOS: estudio descriptivo-transversal, consistente en determinar la calidad del hueso en 30 mujeres con diabetes mellitus tipo 2, y 20 sin diabetes mellitus que constituyeron el grupo control. Se les realizó historia clínica, para precisar: edad, índice de masa corporal, circunferencia de cintura y actividad física; además, en las diabéticas: tiempo de evolución de la diabetes mellitus, glucemia en ayunas y posprandial de 2 h. La calidad del hueso se determinó mediante densitómetro LEXUS y se expresó como contenido mineral óseo y T-score en L2-L4 y el radio. Se utilizaron los criterios de la OMS para definir osteoporosis. Se emplearon estadígrafos descriptivos y correlaciones lineales. RESULTADOS: el 33 % de las pacientes con diabetes mellitus tipo 2 tuvo osteoporosis en el radio, y el 3,3 % en L2-L4, lo que ocurrió en el 75 y el 30 % respectivamente de las no diabéticas. El contenido mineral óseo en: L2-L4 de las diabéticas fue 0,561 g/cm² yen el radiode 0,358 g/cm², mientras en las no diabéticas fue 0,285 y 0,313 g/cm² respectivamente (p de 18,5 kg/m² de superficie corporal (sc y la circunferencia de cintura > de 88 cm con el contenido mineral óseo, y asociación negativa entre el T-score en el radio y la glucemia en ayunas ³ a 7mmol/L, y entre el tiempo de evolución > de 5 años con el contenido mineral óseo en L2-L4 (pBACKGROUND: osteoporosis and diabetes mellitus are health problems for the aging population in general and for females in particular. The metabolic decontrol and the microvascular lesions of DM affect the whole organism, including bones

  16. Evaluación integral de la sensibilidad en los pies de las personas con diabetes mellitus tipo 2

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    Valentina Rivas Acuña

    2017-01-01

    Full Text Available Introducción: Actualmente la diabetes mellitus tipo 2 es considerada una epidemia en el mundo, es uno de los problemas de mayor trascendencia, por su alta prevalencia como por su enorme repercusión social y económica, por tal motivo el propósito del estudio fue evaluar de manera integral la sensibilidad en los pies de las personas con diabetes mellitus tipo 2, de Villahermosa, Tabasco, México. Materiales y Métodos: El diseño fue descriptivo correlacional, la muestra fue de 198 personas. Se utilizó el Test del Michigan Neuropathy Screening con monofilamento de Semme Weinstein, Diapasón, temperatura frío/calor y reflejo Aquileo. Resultados y Discusión: El sexo femenino predominó con un 70.2% y el 29.8% hombres, el promedio de edad fue 56.44 años y 12.34 años promedio con la enfermedad. El 46% registró síntomas neuropáticos moderados, 26.3% graves; el 65.7% riesgo de neuropatía positiva (40.9% mujeres y 24.8% hombres, 41.1% con pérdida de sensibilidad moderada y 29.3% sensibilidad normal; el 74.7% tiene un control glucémico deficiente. Los factores de riesgo detectados con mayor prevalencia fueron helomas, hiperqueratosis y deformidades. Conclusiones: Existe una correlación significativa entre la pérdida de la sensibilidad con los años con la enfermedad, con la hiperglucemia y síntomas de neuropatía, la pérdida de sensibilidad en mujeres es de moderada a grave y en los hombres la pérdida de la sensibilidad es moderada. Cómo citar este artículo: Rivas V, Mateo Y, García H, Martínez A, Magaña M, Carrillo R.  Evaluación integral de la sensibilidad en los pies de las personas con diabetes mellitus tipo 2. Rev Cuid. 2017; 8(1:1423-32. http://dx.doi.org/10.15649/cuidarte.v8i1.348

  17. Animales de experimentación como modelos de la diabetes mellitus tipo 2 Laboratory animals in endocrinology. Biomodels of type 2 diabetes mellitus

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    Beatriz Hugués Hernandorena

    2002-08-01

    Full Text Available Se sabe que los modelos animales utilizados en las investigaciones sobre la diabetes mellitus tipo 2 (DM2, ayudan al estudio de los mecanismos patogénicos que conducen a la presentación de esta enfermedad, acompañada de severa o moderada hiperglucemia, intolerancia a la glucosa y otras alteraciones metabólicas relacionadas con la misma, y dan la oportunidad de explorar nuevos tratamientos y formas de prevenir estos cuadros morbosos. Se brindó información detallada sobre los biomodelos de la DM2, a partir de una revisión bibliográfica sobre el tema, que comprendió los que se originan espontáneamente y los que se logran de forma inducida. Se expusieron los factores ambientales que influyen sobre los mismos, y se describieron aquellos en los que se pueden presentar complicaciones crónicas de la diabetes mellitus no insulinodependiente. Se concluyó que estos biomodelos contribuyen al estudio de los mecanismos que originan esa afección y son de gran utilidad para los investigadores de esta rama de la Endocrinología, aunque no constituyan un reflejo exacto de esta enfermedad en el hombre.It is known that the animal models used in the research of type 2 diabetes mellitus help to study the pathogenic mechanisms leading to the presentation of this disease, accompanied of severe or moderate hyperglycaemia, glucose intolerance and other metabolic alterations related to it, and give the opportunity to explore new treatments and ways of preventing these morbid clinical pictures. Detailed information is given on the biomodels of type 2 diabetes mellitus based on a bibliographic review made on this topic that included those which are spontaneously originated and the ones obtained in an induced way. The environmental factors influencing on them are explained and the biomodels that may present chronic complications of non-insulin dependent diabetes mellitus are also described. It was concluded that these biomodels contribute to the study of the

  18. Estudio observacional prospectivo con insulina detemir en pacientes con diabetes mellitus tipo 2 mal controlados que inician por primer vez tratamiento con insulina (estudio SOLVE

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    Domingo Orozco-Beltrán

    2016-02-01

    Conclusiones: En esta cohorte de pacientes con diabetes mellitus tipo 2 recientemente insulinizados, la insulina detemir (una vez al día mejoró el control glucémico, con baja incidencia de hipoglucemia y una reducción significativa del peso.

  19. Apego al tratamiento farmacológico en pacientes con diagnóstico de diabetes mellitus tipo 2

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    Durán-Varela Blanca Rosa

    2001-01-01

    Full Text Available Objetivos. Establecer la frecuencia de apego al tratamiento farmacológico en pacientes diabéticos tipo 2, relacionarla con el control metabólico e identificar factores que influyen para el no apego. Material y métodos. Estudio transversal comparativo, efectuado en 150 pacientes con diabetes mellitus tipo 2 de la unidad de medicina familiar No. 33 del Instituto Mexicano del Seguro Social de Chihuahua, Chih., México, hecho entre 1997 y 1998. Se midió el apego con cuenta de tabletas en su domicilio. El control metabólico se midió con hemoglobina glucosilada. Un cuestionario investigó factores relacionados. Se utilizó estadística descriptiva, t de Student y razón de momios. Resultados. El apego correspondió a 54.2%. Los factores asociados al no apego fueron la escolaridad primaria y la falta de información sobre la enfermedad (phttp://www.insp.mx/salud/index.html

  20. Género y autocuidado de la diabetes mellitus tipo 2 en el Estado de México

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    Patricia CRUZ-BELLO

    2014-01-01

    Full Text Available La diabetes mellitus es un problema epidemiológico nacional poco tratado en los estudios de género. La obesidad, la inadecuada alimentación y el sedentarismo son factores de riesgo de esta patología que se diagnostica con mayor frecuencia a edades más tempranas, impactando en el equilibrio de las familias. Aunque esta enfermedad se presenta en ambos géneros, la prevalencia es más elevada en mujeres. Se realizó un estudio de diseño transversal con una muestra no probabilística de 239 personas de dos comunidades del Estado de México, a quienes previo consentimiento informado se aplicó un cuestionario para analizar el género como factor de riesgo para el autocuidado en diabetes mellitus tipo 2. El estudio da a conocer los factores no clínicos que pueden considerarse como diferenciales de género. La prevención considera aspectos educativos de autocuidado con un abordaje transdisciplinario e incorporando a la familia para el cuidado de la salud, por sus creencias, saberes y prácticas.

  1. Prevalência de diabetes mellitus tipo 2 e outros fatores de risco associados em pacientes com glaucoma Prevalence of type 2 diabetes mellitus and other associated risk factors in glaucoma patients

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    Jacqueline Coblentz

    2010-02-01

    Full Text Available OBJETIVO: Avaliar a prevalência de diabéticos em uma amostra de pacientes com glaucoma; verificar se existe associação entre diabetes mellitus e glaucoma na amostra estudada; verificar outros fatores de risco associados. MÉTODOS: Foram analisados de forma retrospectiva os prontuários de 50 pacientes com diagnóstico de glaucoma. Os dados registrados foram sexo, idade, raça, história familiar de glaucoma e história pessoal de diabetes mellitus tipo 2. RESULTADOS: Do total de pacientes avaliados, 5 (10% apresentavam diabetes mellitus tipo 2. Destes, 3 eram mulheres e 2 eram homens, com mediana de idade de 81 anos (71-88. A prevalência de diabetes nos pacientes com glaucoma não mostrou diferenças significativas (OR: 1,476; Intervalo de Confiança 95%: 0,4438 a 4,910; p= 0,5352 quando comparada à prevalência de diabetes mellitus tipo 2 na população geral brasileira (7,6%. CONCLUSÃO: Nesta amostra de pacientes com glaucoma, a prevalência de diabetes mellitus tipo 2 foi pouco mais elevada que a da população. Entretanto, nenhuma associação foi encontrada entre diabetes mellitus e glaucoma.PURPOSE: To evaluate prevalence of diabetes mellitus in a group of patients with glaucoma; to verify if there is association between diabetes mellitus and glaucoma; to verify other associated risk factors. METHODS: Fifty(50 glaucoma patients had their medical records analyzed in a retrospective way. Registered data included sex, age, ethnic group, family history of glaucoma and personal history of type 2 diabetes mellitus. RESULTS: Five (10% of all evaluated patients had type 2 diabetes mellitus. 3 of them were female and 2 were male, median age of 81 years old (71-88. Prevalence of diabetes in glaucoma patients did not show significant differences. (OR: 1.476; 95% Confidence Interval: 0.4438 to 4.910; p= 0.5352 when compared to the prevalence of type 2 diabetes mellitus in general brazilian population (7.6%. CONCLUSION: In this group of patients

  2. Apego al tratamiento farmacológico en pacientes con diagnóstico de diabetes mellitus tipo 2 Pharmacological therapy compliance in diabetes

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    Blanca Rosa Durán-Varela

    2001-06-01

    Full Text Available Objetivos. Establecer la frecuencia de apego al tratamiento farmacológico en pacientes diabéticos tipo 2, relacionarla con el control metabólico e identificar factores que influyen para el no apego. Material y métodos. Estudio transversal comparativo, efectuado en 150 pacientes con diabetes mellitus tipo 2 de la unidad de medicina familiar No. 33 del Instituto Mexicano del Seguro Social de Chihuahua, Chih., México, hecho entre 1997 y 1998. Se midió el apego con cuenta de tabletas en su domicilio. El control metabólico se midió con hemoglobina glucosilada. Un cuestionario investigó factores relacionados. Se utilizó estadística descriptiva, t de Student y razón de momios. Resultados. El apego correspondió a 54.2%. Los factores asociados al no apego fueron la escolaridad primaria y la falta de información sobre la enfermedad (phttp://www.insp.mx/salud/index.htmlObjective. To establish the frequency of compliance to pharmacological therapy, and to identify non-compliance factors, in relation to metabolic control on patients with type-II diabetes mellitus. Material and methods. A comparative cross-sectional study was conducted between 1997 and 1998, among 150 type-II diabetic patients, at the Family Medicine Unit No. 33, of the Mexican Institute of Social Security, in Chihuahua, Mexico. Compliance to drug therapy was measured by counting tablets at home. Metabolic control was measured through glycosilated hemoglobin. A questionnaire was given to collect data on factors related to compliance. Statistical analysis consisted of descriptive statistics, Student's t and odds ratios. Results. Pharmacological therapy compliance was 54.2%. Factors associated with non-compliance were elementary schooling and lack of information about the disease. Conclusions. Pharmacological therapy compliance was low. Factors related to non-compliance can be modified through education. The English version of this paper is available at: http://www.insp.mx/salud/index.html

  3. Complicaciones microvasculares en niños con diabetes mellitus tipo I

    OpenAIRE

    Machado1, Karina; Freire, María Victoria; Pérez, María del Luján; Montano4, Alicia

    2013-01-01

    Introducción: la diabetes mellitus (DM1) es la enfermedad crónica endocrinológica más frecuente en pediatría y de mayor repercusión sanitaria por la gravedad de sus complicaciones. Dentro de estas complicaciones tienen especial relevancia la afectación de la microvasculatura, que causa retinopatía, neuropatía y nefropatía. Estas complicaciones, si bien se manifiestan durante la edad adulta, comienzan a desarrollarse en la niñez. Existen normas internacionales para su identificación. Se citan ...

  4. PREJUÍZOS COGNITIVOS EM IDOSOS COM DIABETES MELLITUS TIPO 2

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    Regina Maria Fernandes Lopes

    2009-12-01

    Full Text Available The advance of health conditions is propitiating the progressive increase of longevity and life expectancy. Studies have identified the existence of a connection between Diabetes Mellitus and (DM and dementia. The hyperglycemia can be a significant factor for the incidence of Alzheimer, which could be a secondary cause for dementia. Type 2 Diabetes Mellitus (DM2 is associated to cognitive and functional deficits and, one of the tools, which can be used to assess executive functions, is the WCST. The objetive was the assessment of the cognitive prejudice in older people with DM2 through the WCST. Two hundred and fifty four (254 old people of both genders, with 60 years of age or older, divided into 44 persons with a DM2 diagnosis and 210 old people of the control group from the general population. The design was that of a quantitative and transversal study. The instruments used were: sociodemographic filing cards, WCST, MMSE, BDI, BAI, GDS. The Vocabulary, Coding, Digit Span, Block Design and WAIS – III sub-tests. The results showed there were a significant difference in the performance of old people with DM2, when compared to old people of the control group in four describers of the WCST, cognitive prejudice. The old people with DM2 showed intensity of depressive and anxiety symptoms of statistically larger regarding the group control.

  5. Estilos de vida y factores de riesgo asociados a Diabetes Mellitus Tipo 2

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    Saltos-Solís, Marisela

    2012-07-01

    Full Text Available Type 2 diabetes mellitus, which is a chronic non-communicable illness, is a public health problem characterized by chronic hyperglycemia with an altered state of carbohydrates, lipids and proteins in the metabolism resulting from inappropriate secretion of insulin by the pancreas. This study, which is observational, not experimental, descriptive and transversal, was conducted in the León Becerra Hospital in the Milagro with 90 diabetes patients. It, determines how lifestyle and exposure to multiple risk factors cause the disease. We evaluated blood glucose, cholesterol, fasting triglycerides, BMI, blood pressure, considering personal and family medical history, years of disease and organ complications. The data was analyzed using EpiInfo 2000 CDC USA. It is essential to educate the diabetic patients in controlling their disease to avoid complications and improve their quality of life.

  6. Necessidades especiais de escolares com diabetes mellitus tipo 1 identificadas por familiares Special needs of students with diabetes mellitus type 1 identified by relatives

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    Tania Moron Saes Braga

    2012-09-01

    Full Text Available É um desafio atender aos alunos, em suas diversas necessidades especiais. Diferentemente das deficiências, há poucas pesquisas no Brasil sobre estudantes com doenças crônicas e suas especificidades, na escola. O objetivo do presente estudo foi identificar as necessidades especiais de escolares com diabetes mellitus tipo 1. Participaram 37 familiares de escolares em tratamento ambulatorial de uma faculdade paulista, por meio de entrevista semiestruturada, gravada em áudio e transcrita para análise. Os resultados mostraram que todos comunicaram a escola a respeito da doença do filho, mas, mesmo assim, 29,7% relatam dificuldade de inclusão ou acesso à escola, como desconhecimento do professor para o controle do diabetes, merenda escolar inadequada, preconceito dos colegas e da diretora ou vergonha por parte do aluno. As faltas ocorrem com 70,3% dos alunos, principalmente devido às consultas médicas. Necessidades especiais foram identificadas por 32,4%, incluindo a alimentação, o desempenho escolar e a necessidade de profissionais da escola mais bem informados sobre a doença. Além disso, 72,9% referem algum tipo de apoio para enfrentar o diabetes, principalmente de profissionais de saúde. Dos familiares, 51,3% apresentam sugestões para um melhor desenvolvimento do filho na escola, incluindo alimentação escolar adequada e melhor preparo da escola para lidar com o diabetes, como palestras e treinamento aos professores. Sugerimos a aproximação entre a escola e a área da saúde, porém, o primeiro passo para a integração intersetorial é identificar as necessidades desses alunos com doenças crônicas, como foi possível com este trabalho, ao enfocar o diabetes mellitus e suas repercussões escolares.Catering to students according to their various special needs is a challenge. As opposed to the field of disability, there is little research in Brazil on students with chronic diseases and their specific needs at school. The

  7. Modelo de manejo de casos en pacientes con diabetes mellitus tipo 2 Case management model in patients with type 2 diabetes mellitus

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    María Guadalupe Martínez de Dávila

    2006-03-01

    Full Text Available Objetivo: Implementar el modelo de manejo de casos y evaluar su efectividad en pacientes hospitalizados con diabetes mellitus tipo 2 Metodología: Muestra de 17 pacientes hospitalizados con diabetes mellitus tipo 2 para dos grupos, experimental y control. Etapas del estudio: a selección de pacientes y capacitación del equipo multidisciplinario, b intervención multidisciplinaria y c seguimiento en el hogar. Resultados: Grupo experimental: media de días estancia hospitalaria de 4.88. Sólo 11.8% de los pacientes tuvo un reingreso hospitalario en los seis meses posteriores al egreso. Media de hemoglobina glucosilada al ingreso al hospital 11.45%; al finalizar la intervención 8.84%, la prueba de comparación de medias t de Student reportó diferencia significativa (p=.001. Grupo control: media de días estancia de 6.24. En los siguientes seis meses 35.3% tuvieron de uno a dos reingresos. Conclusiones: El grupo experimental reportó menores días estancia y reingresos hospitalarios, mayor conocimiento y acciones de autocuidado para el tratamiento de la enfermedad, mayor involucramiento de la familia en el cuidado y mejor control glucémico a través de la hemoglobina glucosilada.Aim: To implement the Case Management Model and to assess its effectiveness in patients with type 2 diabetes mellitas. Methodology: Two seveenteen patients groups were sampled. One was experimental and the second was a control group Study stages: a selection of patients and training of the multi-disciplinary team, b multi-disciplinary intervention, c follow-up at home. Results: Experimental group: mean days of hospital stay were 4.88. Only 11.8% of patients had one hospital readmission within the six months after the discharge. Mean of glycosilated hemoglobin at hospital admission: 11.45%.At the end of intervention: 8.84%. The t student comparison of means showed a significant difference (p= 001. Control group: mean days of stay was 6.24. In the following six months 35

  8. Dislipidemia y microalbuminuria en niños con diabetes mellitus de tipo 1 Dyslipidemia and microalbuminuria in children presenting with type 1 diabetes mellitus

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    Alexander García Cabreja

    2009-03-01

    Full Text Available INTRODUCCIÓN. La diabetes mellitus de tipo 1 es una enfermedad autoinmunitaria que se caracteriza por una deficiencia absoluta de la producción de insulina, alteraciones del metabolismo de la glucosa, los lípidos y las proteínas. El objetivo de nuestra investigación fue conocer la relación entre dislipidemia y lesión renal diabética, expresada por la presencia de microalbuminuria. MÉTODOS. Se estudiaron 52 niños con diabetes mellitus de tipo 1, edades de 9 a 15 años y 2 años o más de duración de la enfermedad. A todos se les realizó lipidograma en ayunas que incluyó análisis de triglicéridos, colesterol total, colesterol de las lipoproteínas de baja densidad y colesterol de las lipoproteínas de alta densidad. Se realizaron pruebas de microalbuminuria mediante radioinmunoanálisis para la albúmina humana en orina y también filtrado glomerular. RESULTADOS. Se observó dislipidemia en 30 pacientes (57 % y disminución del colesterol de lipoproteínas de alta densidad en todos los pacientes dislipidémicos. Se constató un aumento del colesterol de lipoproteínas de baja densidad en 27 casos (51,9 %; el colesterol total estaba elevado en 12 (23 % y se comprobó hipertrigliceridemia solo en 4 pacientes (7,6 %. Veintiuno de los 30 niños dislipidémicos (70 % tenían microalbuminuria. Se encontró que los pacientes con dislipidemia tenían mayor porcentaje de microalbuminuria, pero éste no fue significativo. En todos los pacientes con dislipidemia se observó una disminución del colesterol de lipoproteínas de alta densidad. La dislipidemia tuvo correlación positiva con la duración de la diabetes, pero no con el sexo. CONCLUSIONES. En la diabetes mellitus de tipo 1, el colesterol total y los triglicéridos no ofrecen información suficiente y es necesario realizar estudios del colesterol de lipoproteínas de alta densidad para poder pronosticar una futura lesión renal. No sólo el control glucémico, sino también el control

  9. Adherencia al tratamiento nutricional en pacientes con diabetes mellitus tipo 2 que asisten a un programa educativo

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    Mariela A. Carvajal

    2017-03-01

    Full Text Available El objetivo de este estudió fue evaluar la adherencia al tratamiento nutricional por medio de la hemoglobina glicosilada en pacientes con diabetes mellitus tipo 2 que asistieron a un programa educativo en diabetes en la ciudad de Guatemala, así como evaluar los principales factores que influyen en ella. Se realizó un estudio de tipo prospectivo, longitudinal, experimental, pareado de intervención no medicamentosa. Se utilizó la prueba de Morinsky-Green Levine para evaluar la adherencia al tratamiento nutricional, el cual consiste en cuatro preguntas de auto informe sobre la adherencia. La muestra estuvo conformada por 126 pacientes que recibieron una intervención educativa durante cinco meses. La metodología utilizada permitió analizar la adherencia al tratamiento por medio de la prueba de hemoglobina glicosilada, una encuesta de adherencia, evaluación del consumo por grupos de alimentos al inicio y al final. Uno de los principales hallazgos fue que los pacientes están convencidos que su plan nutricional les beneficia y les evitaría complicaciones. El apoyo familiar también juega un papel muy importante en la adherencia de estos pacientes al tratamiento nutricional. Los indicadores de adherencia que se encontraron más afectados son los relacionados al costo del plan de alimentación y la dificultad para seguirlo. Se concluye que es posible utilizar la hemoglobina glicosilada como un indicador efectivo de adherencia, ya que el porcentaje de pacientes con hemoglobina glicosilada controlada aumentó de un 50 a un 65.9% después de la intervención.

  10. O cuidar de uma criança com diabetes mellitus tipo 1: concepções dos cuidadores informais

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    Catarina Aparecida Sales

    2009-09-01

    Full Text Available O Ministério da Saúde define Diabetes mellitus como síndrome de etiologia múltipla, decorrente da falta da insulinae/ou da incapacidade da insulina exercer adequadamente seus efeitos. Essa doença vem apresentando incidência comproporções cada vez maiores em nosso meio. Assim, nesse estudo, nosso objetivo foi compreender os sentimentossuscitados pelos cuidadores informais que cuidam de crianças menores de 12 anos com Diabetes mellitus tipo 1. Paratanto, optamos por um estudo qualitativo, embasado nos princípios da fenomenologia existencial. A pesquisa foirealizada em uma cidade do Noroeste do Paraná, nos meses de junho e julho de 2007. Os seis entrevistados foraminquiridos com a seguinte questão: “O que significa para você cuidar de uma criança diabética?". Da análiseemergiram quatro categorias: descobrindo o diagnóstico do filho; convivendo com a doença; vivenciando anecessidade de compartilhar seu pesar e; a importância da espiritualidade para o entendimento da situação.Depreendemos que vivenciar esta situação é um fardo difícil de ser abarcado pelos cuidadores e que o impacto dadoença pode causar crises de adaptação no enfrentamento da família. Portanto, devemos estar atentos ao modo comoo portador de diabetes e seus familiares sentem, enfrentam e interpretam o diabetes e seu tratamento.

  11. ESTUDIO DEL PERFIL LIPÍDICO EN SUJETOS CON DIABETES MELLITUS TIPO 2 DE BOGOTÁ

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    M. Guerra

    2005-12-01

    Full Text Available Los diabéticos tipo 2 (DM 2 pobremente controlados (HbA1c = 7% exhiben disminución del estado antioxidante total y dislipidemia en comparación con los metabólicamente controlados, lo cual puede ser reflejo de incrementos de radicales libres de oxígeno, alteraciones del metabolismo de las lipoproteínas lo que contribuye a desarrollar fenómenos que conducen a complicaciones micro y macrovasculares. Se estudiaron 60 individuos (40-80 años no controlados (n=20, controlados (n=20 y sanos (n=20. El criterio del buen control de la diabetes fue % HbA1c < 7%. Mediante la prueba t de diferencia de medias suponiendo varianzas desiguales se compararon los grupos. Los niveles de Col T, LDL-C, VLDL-C, TG y apo B-100 fueron significativamente más altos (p<0.05 y los de HDL-C y apo A-I más bajos en los DM 2 no controlados comparados con los niveles de los grupos de sujetos con DM 2 controlados y los controles sanos. Los pacientes con regular o pobre control glicémico presentan un perfíl lipídico anormal. Estos resultados son similares al de otros investigadores de diversas latitudes.

  12. Diabetes tipo 2 en niños y adolescentes: aspectos clínico-epidemiológicos, patogénicos y terapéuticos Type 2 diabetes mellitus in children and adolescents: clinicoepidemiological, pathogenic and therapeutic aspects

    OpenAIRE

    Manuel Emiliano Licea Puig; Mirelkis Bustamante Teijido; Maritza Lemane Pérez

    2008-01-01

    OBJETIVO: debido al incremento sostenido en la incidencia de la diabetes mellitus tipo 2 en personas < 20 años, nos proponemos revisar aspectos clínico-epidemiológicos, patogénicos y terapéuticos de la diabetes mellitus tipo 2 en niños y adolescentes. DESARROLLO: en la infancia, se estima que la diabetes mellitus tipo 2 representa del 2-3 % de todos los casos. Sin embargo, en los últimos años ha mostrado un incremento de 10 veces. Su prevalencia es mayor en afroamericanos, hispanos y nativos ...

  13. Plan de Cuidados Estandarizado de Enfermería para pacientes con Diabetes Mellitus tipo 2 en la Atención Primaria

    OpenAIRE

    Tejido Ruiz-Ogarrio, Andrea Elisa

    2015-01-01

    Siendo la Diabetes Mellitus una de las enfermedades crónicas con más prevalencia mundial y con una incidencia aumentada en los últimos años, se ha visto necesario la estructuración de un Plan de Cuidados Estandarizado de Enfermería en Atención Primaria. Con este Plan de Cuidados, se conseguiría frenar el progreso de la enfermedad en pacientes diagnosticados de Diabetes Mellitus tipo 2, enfermedad generalmente asociada a personas en edad adulta con sobrepeso, por lo que la consulta de enfermer...

  14. Prevalencia de cardiopatía isquémica asintomática en pacientes con diabetes mellitus tipo 2

    OpenAIRE

    Dulman O. Pineda-De Paz; Mario R. Pineda-De Paz; Yu L. Lee-Tsai; Clara E. Chang; Lissette C. Torres-Salazar; Luis C. Barrios-Lupitou

    2018-01-01

    Resumen: Introducción: La enfermedad cardiovascular es la causa principal de muerte en pacientes con diabetes mellitus. La prevalencia de cardiopatía isquémica asintomática es más alta en pacientes diabéticos que en no diabéticos y se asocia a peor pronóstico. Objetivo: Identificar la prevalencia de cardiopatía isquémica asintomática en pacientes con diabetes mellitus tipo 2 en un hospital de tercer nivel de atención de Guatemala y analizar la posible asociación de dicha enfermedad con carac...

  15. Oxidative stress in patients with type 2 diabetes mellitus treated with metformin = Estresse oxidativo em pacientes com diabetes mellitus tipo 2 em tratamento com metformina

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    Dries, Samuel Selbach

    2017-01-01

    RESULTADOS: A amostra inicial foi composta por 49 pacientes com idade de 59±9 anos e índice de massa corporal de 29,8±5,1 kg/m2 , com diabetes por uma mediana de tempo de 36 (intervalo interquartil 1-240 meses e em uso de metformina há uma mediana de 36 (intervalo interquartil 1-180 meses. Vinte e cinco pacientes deixaram o estudo entre a segunda e a quarta reunião. Os níveis de malondialdeído diferiram entre antes e após o acompanhamento farmacoterapêutico, correlacionando-se positivamente com glicemia, glicohemoglobina e triglicerídeos e negativamente com metformina e superóxido dismutase. Encontrou-se elevação da glicemia, glicohemoglobina e malondialdeído, e diminuição da metformina no grupo com complicações diabéticas, e foi identificada correlação entre malondialdeído e o número de complicações diabéticas por paciente. CONCLUSÕES: Nesta amostra de pacientes com diabetes mellitus tipo 2 em tratamento com metformina, o estresse oxidativo foi mais pronunciado nos que apresentavam pior controle glicêmico e complicações diabéticas

  16. Repercusión y tratamiento de los aspectos psicosociales de la diabetes mellitus tipo 1 en adolescentes

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    Alina Barroso Lorenzo

    Full Text Available La diabetes mellitus tipo 1 es la endocrinopatía más frecuente en niños y adolescentes, con una tendencia al aumento de la incidencia mundial. De evolución crónica, lleva tratamientos de por vida, con limitaciones y aparición de complicaciones, que se hacen más difíciles de manejar en la etapa de la adolescencia, etapa en la que deben cumplir un grupo de tareas propias del desarrollo para garantizar su normal crecimiento hacia la adultez, además de sortear las dificultades de la enfermedad. Durante el proceso de duelo los mecanismos de afrontamiento en pacientes y familiares pueden ser desadaptativos. Son frecuentes la disfunción familiar y los trastornos emocionales, como la depresión, ambos factores causas, a menudo, de mal control metabólico. La psiquiatría de enlace constituye una herramienta fundamental en el diagnóstico y tratamiento de estas alteraciones. A pesar de la importancia, no se encuentran suficientes publicaciones sobre el tema en nuestro medio, por lo cual el objetivo del trabajo es dar a conocer elementos teóricos sobre los aspectos psicosociales en adolescentes diabéticos.

  17. Lócus de controle em saúde e autoestima em portadores de diabetes mellitus tipo 2

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    Fernanda Silva Fuscaldi

    2011-08-01

    Full Text Available O presente estudo teve como objetivo relacionar os escores obtidos pela aplicação das escalas de lócus de controle da saúde e autoestima com variáveis sócio-demográficas, clínicas, fatores de risco e complicações crônicas em 65 portadores de diabetes mellitus do tipo 2. Trata-se de um estudo descritivo transversal onde foram utilizados, para a análise estatística, os testes de Qui-quadrado de Pearson, Mann-Whitney, Kruskal-Wallis e de Correlação de Spearman. Em relação ao lócus de controle, os pacientes apresentaram, em média, maiores escores na dimensão interna, sendo que as mulheres demonstraram maior externalidade-ao acaso para a saúde. Relações estatisticamente significativas foram encontradas entre internalidade com tempo de diagnóstico e atividade física; entre externalidade-outros poderosos com hemoglobina glicada e atividade física e entre externalidade-ao acaso com a prática de atividade física. A autoestima foi alta na maioria dos indivíduos, porém não se relacionou estatisticamente a nenhuma variável.

  18. Síndrome DRESS inducido por fármacos antituberculosos en un paciente con diabetes mellitus tipo 2

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    Antonio Salas

    2012-04-01

    Full Text Available Presentamos el caso de un paciente varón de 48 años de edad, con diagnóstico de diabetes mellitus tipo 2, no controlada, de diez años de evolución, a quien se le diagnosticó tuberculosis pulmonar mediante signos clínicos, radiográficos y cultivo en esputo positivo para Mycobacterium tuberculosis, sensible a drogas antituberculosas de primera línea. Recibió isoniacida, rifampicina, etambutol y pirazinamida. Dos meses después de iniciado el tratamiento presentó hipersensibilidad a medicamentos, con los siguientes signos y síntomas: rash dérmico generalizado, prurito generalizado, anemia Coombs positiva, eosinofilia y síntomas sistémicos, compatibles con el síndrome DRESS (drug rash with eosinophilia and systemic symptoms. Ante ello, se suspendió la medicación antituberculosa y se instaló tratamiento con antihistamínicos y corticoides sistémicos, con remisión y mejoría de síntomas. Posteriormente, recibió un esquema individualizado de tratamiento para tuberculosis consistente en medicamentos mínimamente hemato-hepatotóxicos, similar al indicado en pacientes inmunosuprimidos. Desde entonces presenta baciloscopias negativas.

  19. Frecuencia de maculopatía en pacientes con diabetes mellitus tipo 2: Reporte preliminar Frequency of maculopathy in patients with type 2 diabetes mellitus: A preliminary report

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    Harberth Fernández Leyva

    2002-08-01

    Full Text Available Se realizó un estudio transversal de 542 pacientes con diabetes mellitus tipo 2 (DM2 ICA- reclutados consecutivamente en el Centro de Atención al Diabético. Se les hizo historia clínica completa y examen oftalmológico: biomicroscopia y oftalmoscopia (directa e indirecta y examen con lente de 90 Dp. Se determinó glucemia en ayunas, 2 h después del desayuno y del almuerzo, hemoglobina glucosilada (HbA1 y excreción urinaria de albúmina (EUA. La maculopatía se clasificó en exudativa, edematosa e isquémica, y se relacionó con el sexo, hábito de fumar, tratamientos de la DM, edad actual, edad al comienzo de la enfermedad, presión arterial y las variables bioquímicas: glucemia en ayunas, posprandiales, HbA1 y EUA. Se excluyó la nefropatía clínica (EUA ³ 300 mg/L. Se consideró DM2 de reciente presentación cuando el diagnóstico clínico era menor de 6 meses. Padecían algún tipo de maculopatía 95 (17,5 % pacientes: 49 (9,0 %, formas exudativas; 29 (5,3 %, edematosas y 17 (3,2 %, isquémicas. No se hallaron diferencias significativas con el sexo, hábito de fumar o tratamientos utilizados, al dividirlos según la presencia o no de maculopatía. La duración de la DM fue de 12,4 ± 9,45 años para los pacientes con maculopatía, con diferencia estadísticamente significativa (p A cross-sectional study was conducted among 542 patients with ICA-type 2 diabetes mellitus consecutively recruited at the Diabetic Care Center. A complete medical history and an ophthalmological examination: biomicroscopy and ophthalmoscopy (direct and indirect and examination with lens of 90Dp were made. Fasting glycaemia, 2 hours after breakfast and lunch, glycosilated haemoglobin (HbA1 and urinary albumin excretion (UAE were determined. Maculopathy was classified as exudative, edematous and ischaemic and it was related to sex, smoking habit, treatments of DM, present age, age at the onset of the disease, arterial pressure and biochemical variables, such

  20. Estudo da prevalência de hipoacusia em indivíduos com diabetes mellitus tipo 1 Hearing loss prevalence in patients with diabetes mellitus type 1

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    Diego Augusto Malucelli

    2012-06-01

    Full Text Available Diabetes mellitus (DM é uma doença crônica causada pela não produção e uso inadequado de insulina. Enfermidade crônico-degenerativa. Complicações crônicas do DM, no sistema auditivo, podem causar atrofia do gânglio espiral, degeneração da bainha de mielina do VIII par craniano, diminuição de fibras nervosas na lâmina espiral ou espessamento das paredes capilares da estria vascular e das pequenas artérias. OBJETIVO: Verificar os limiares auditivos em indivíduos portadores de DM tipo 1. MATERIAL E MÉTODOS: Estudo clínico envolvendo 60 indivíduos, divididos em Grupo Estudo (GE e Grupo Controle (GC, indivíduos diabéticos e não diabéticos. Realizada anamnese, exame físico, otorrinolaringológico e exame audiométrico. RESULTADOS:Quanto aos limiares de audibilidade, no GE, houve diferença estatisticamente significante nas frequências 250, 500, 10.000, 11.200, 12.500, 14.000 e 16.000 Hz em ambas as orelhas e médias das orelhas. Na comparação dos GE e GC, houve diferença estatisticamente significativa com maior probabilidade de ocorrência de hipoacusia em alguma frequência independente da orelha testada no GE. CONCLUSÕES: Houve diferenças estatisticamente significativas nos achados audiológicos no GE quando comparado com GC, justificando avaliação audiológica completa em pacientes diabéticos tipo 1, incluindo audiometria de altas frequências.Diabetes mellitus (DM is a chronic degenerative disease that impairs normal insulin production and use. DM chronic auditory complications may include spiral ganglion atrophy, degeneration of the vestibulocochlear nerve myelin sheath, reduction of the number of spiral lamina nerve fibers, and thickening of the capillary walls of the stria vascularis and small arteries. OBJECTIVE: This paper aims to verify the hearing thresholds of individuals with type 1 DM. MATERIALS AND METHODS: Sixty patients were enrolled in this trial and divided into case and control groups featuring

  1. RADIOEMISSÕES SOLARES TIPO II ASSOCIADAS A FLARES E CMES

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    Rafael Douglas Cunha-Silva

    2013-12-01

    Full Text Available Atribuídas a ondas de choque e a ejeções de plasmoide, as emissões solares tipo II são ondaseletromagnéticas geradas a partir de oscilações do plasma coronal. A origem dos choques associados a essasemissões é ainda uma questão em aberto da física solar. Enquanto alguns trabalhos sugerem os flares solarescomo seus acionadores, outros fornecem indícios de serem as ejeções de massa coronal (CMEs sua origemmais provável. Este trabalho apresenta os resultados da análise de duas emissões tipo II, registradas por doisespectrômetros da rede e-CALLISTO (extended-Compound Astronomical Low-cost Low-frequency Instrument forSpectroscopy and Transportable Observatory, os quais operam na faixa de frequências de 45-870 MHz. Oprimeiro evento, observado em 13 de junho de 2010, às 05:38 UT, apresentou uma taxa de deriva em frequênciade -0,2 MHz s-1, correspondente a uma velocidade de choque de 528 km s-1, estando, temporalmente, associadoa uma CME lenta (~320 km s-1 e a um flare solar em raios-X, classe M1.0. O segundo evento, observado em 09de Agosto de 2011, às 08:02 UT, apresentou uma taxa de deriva em frequência de -1,4 MHz s-1, correspondentea uma velocidade de choque de 1375 km s-1, estando, temporalmente, associado a uma CME tipo halo (~1610km s-1 e a um flare solar em raios-X, classe X6.9. Os resultados obtidos, para os parâmetros observacionais dasemissões tipo II e para os parâmetros físicos de suas fontes, são discutidos no contexto de sua relação com seuflares e CMEs associados.

  2. Factores predictivos de la microalbuminuria en pacientes pediátricos con diabetes mellitus tipo 1 (DMt1

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    Paola Marianella Pinto Ibárcena

    2012-10-01

    Full Text Available La nefropatía constituye la complicación más grave de la diabetes mellitus tipo 1 (DMt1 siendo una de las manifestaciones iniciales la microalbuminuria. Objetivos: Determinar el comportamiento de los factores epidemiológicos, clínicos y bioquímicos en el desarrollo de microalbuminuria en pacientes con DMt1. Diseño: Estudio de casos y controles. Lugar: Servicio de Endocrinología del Instituto Nacional de Salud del Niño, Lima, Perú. Participantes: Pacientes diabéticos tipo 1 menores de 18 años. Intervenciones: Se estudió 64 pacientes portadores de DMt1, 22 con microalbuminuria y 42 sin esta manifestación, que constituyeron los casos y controles respectivamente. Se consignó como factores epidemiológicos la edad al diagnóstico, tiempo de evolución, género, antecedentes familiares de diabetes, nefropatía, dislipidemia, hipertensión arterial; como factores clínicos, el estado nutricional, desarrollo puberal (Tanner, presión arterial; y como factores bioquímicos, la hemoglobina glicosilada (HbA1c, microalbuminuria y perfil lipídico. Tanto los casos como los controles fueron seguidos durante un año. El análisis estadístico se hizo mediante pruebas de chi cuadrado, odds ratio y regresión logística, para establecer predominancia de factores. Principales medidas de resultados: Estadio puberal, perfil lipídico y HbA1c. Resultados: Los factores de riesgo hallados fueron la presión arterial diastólica elevada (p=0,037, la pubertad (p=0,008, HbA1c alta (p< 0,0001, hipertrigliceridemia (p= 0,007 y la hipercolesterolemia (p< 0,0001. Conclusiones: La HbA1c elevada, la hipercolesterolemia y la pubertad fueron los factores de riesgo de mayor preponderancia para el desarrollo de microalbuminuria. A fin de prevenir el desarrollo de microalbuminuria, se sugiere buen control metabólico y cuidadoso manejo de la dislipidemia, en especial en pacientes púberes.

  3. Análisis de asociación de polimorfismos en DNA mitocondrial y diabetes Mellitus tipo 2

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    Andrés Ruiz

    2001-04-01

    Full Text Available

    La diabetes mellitus tipo 2 (DM2 es una enfermedad con herencia compleja, poligénica con heterogenidad genética de locus, cuya susceptibilidad se ha evaluado para más de 250 genes potencialmente involucrados, y se ha encontrado ligamiento a diferentes cromosomas dependiendo de la etnia; además, se han identificado mutaciones en el DNA mitocondrial (mtDNA responsables de DM2, que explican menos del 2% de los casos de DM2 con patrón de herencia materna; se ha tratado de explicar los demás casos con polimorfismos en mtDNA que estén en desequilibrio de ligamiento con cambios en la región
    control (D-Loop que impliquen variación en la eficiencia de la replicación y la transcripción del mtDNA; estos polimorfismos se han utilizado para caracterizar poblaciones humanas; es así como en las poblaciones fundadoras del continente americano se han encontrado haplotipos polimórficos asociados ampliamente a DM2 y obesidad.
    La alta frecuencia de haplotipos mitocondriales amerindios en la
    población antioqueña, nos condujo a hipotetizar que la incidencia de DM2 en nuestro medio se podría explicar por la interacción entre polimorfismos en genes nucleares con haplotipos mitocondriales ancestrales, que conduce a DM2 y obesidad.
    Este trabajo pretende evaluar el grado de asociación entre la
    diabetes tipo 2 y los polimorfismos del mtDNA mediante un estudio de casos y controles.
    Comparar estadísticamente las frecuencias alélicas y haplotípicas
    de loci polimórficos en el mtDNA entre el grupo de casos y el grupo control.

     

  4. Nivel de conocimientos sobre la enfermedad en los adultos mayores con diabetes mellitus tipo 2 Level of knowledge concerning diabetes mellitus type-2 in the elderly

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    María de la C Casanova Moreno

    2011-06-01

    Full Text Available Se realizó una investigación epidemiológica, descriptiva y transversal, con el objetivo de determinar el nivel de conocimientos sobre diabetes mellitus en los adultos mayores con diabetes tipo 2 durante el año 2010, en el área de salud Hermanos Cruz de la provincia de Pinar del Río. Se incluyeron 91 pacientes diabéticos tipo 2 que recibieron el servicio de atención integral al diabético de ambos sexos y en las edades de 60 y más años (n=91. Para determinar el nivel de conocimientos se aplicó una encuesta diseñada por los especialistas del Centro Provincial de Promoción y Educación para la Salud de la provincia; con los datos obtenidos se confeccionó una base de datos utilizando el programa EpiInfo 2002. Se hizo uso de la estadística descriptiva, los datos para su análisis fueron reflejados en cuadros de distribución de frecuencias y gráficos. Predominó el sexo femenino, la enfermedad crónica no transmisible que más se asoció fue la hipertensión arterial. El nivel de conocimientos fue insuficiente en todos los grupos según el tiempo de evolución de la enfermedad, lo mismo sucedió con los pacientes con complicaciones crónicas. Los diabéticos adultos mayores necesitan fortalecer la educación diabetológica para mejorar los conocimientos sobre la enfermedad y tener una mejor calidad de vida.An epidemiological, descriptive and cross-sectional research was carried out in 2010 with the objective of determining the level of knowledge concerning diabetes mellitus type-2 in the elderly suffering from this disease at "Hermanos Cruz" health area, Pinar del Rio. Ninety one (91 diabetic- type-2 patients attended to the comprehensive care service for both sexes, ages of 60 years old and older (n=91 participated in the study. To determine the level of knowledge a survey was applied, this was prepared by the specialists of the Provincial Center for Health Promotion and Education, arranging a database supported on these results and

  5. Prevalence of Gastroesophageal Reflux Disease in Type II Diabetes Mellitus

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    Huihui Sun

    2014-01-01

    Full Text Available Background/Aims. Patients with type II diabetes mellitus (DM were known to have higher prevalence of gastroesophageal reflux disease (GERD in the Western countries, but data on the impact of GERD on DM patients in our country are scarce. The aim of this study was to evaluate the prevalence of GERD in type II DM patients in Shanghai, China, and to explore its possible risk factors. Methods. 775 type II DM cases were randomly collected. Reflux Disease Questionnaire (RDQ was used to check the presence of GERD. Patients’ characteristics, laboratory data, face-to-face interview, nerve conduction study, and needle electromyogram (EMG test were analyzed. Results. 16% patients were found with typical GERD symptoms. Pathophysiological factors such as peripheral neuropathy, metabolism syndrome, and obesity were found to have no significant differences between GERD and non-GERD type II DM patients in the present study. Conclusion. The prevalence of GERD in type II DM patients is higher than that in adult inhabitants in Shanghai, China. No difference in pathophysiological factors, such as peripheral neuropathy, and metabolism syndrome was found in DM-GERD patients, suggesting that further study and efforts are needed to explore deeper the potential risk factors for the high prevalence rate of GERD in DM patients.

  6. Malformação de Chiari do tipo II sintomática

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    SALOMÃO J. FRANCISCO

    1998-01-01

    Full Text Available Os autores analisam uma série de 17 crianças portadoras de mielodisplasias que desenvolveram sinais e sintomas da malformação de Chiari do tipo II. De acordo com a idade, dois grupos ficaram bem definidos: Grupo I, crianças no primeiro ano de vida, em que predominaram sinais e sintomas de comprometimento do tronco encefálico e nervos cranianos bulbares (n=13; Grupo II, composto por crianças com idade superior a um ano, em que as principais manifestações foram dor cervical e sinais cerebelares (n=4. O resultado do tratamento cirúrgico nos dois grupos foi distinto: enquanto a mortalidade no Grupo I atingiu 46,1%, nenhum paciente do Grupo II veio a falecer. O tratamento inicial consistiu na instalação ou revisão de derivação ventricular, sendo a descompressão crânio-vertebral reservada àqueles que não se beneficiaram com esses procedimentos. Os autores enfatizam a necessidade do imediato reconhecimento e tratamento do quadro, de modo a se obter resultados satisfatórios.

  7. Uso da caneta injetora de insulina no tratamento do diabetes mellitus tipo 1 Insulin pen injector for the treatment of type 1 diabetes mellitus

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    Frederico F.R. Maia

    2002-01-01

    Full Text Available Objetivo: avaliar a literatura médica quanto aos impactos do uso da caneta de insulina em relação à terapia convencional com seringas no tratamento do diabetes mellitus tipo 1 em crianças e adolescentes. Métodos: revisão da literatura nos últimos dez anos através de pesquisa no Medline, selecionando os artigos pertinentes ao objetivo do trabalho. Resultados: o uso da caneta injetora de insulina está cada vez mais disseminado em todo o mundo, trazendo maior conforto e comodidade para os pacientes. Está associado à melhora do controle metabólico, maior aceitação da doença, menor risco de crises hipoglicêmicas, maior segurança de dose, maior facilidade de uso e melhora da qualidade de vida dessa população. Conclusão: a evolução tecnológica proporciona o surgimento de novas formas de aplicação de insulina na busca de maior conforto e comodidade para os pacientes, permitindo controle adequado da glicemia e redução das complicações a curto prazo, como através do uso das canetas de insulina. Os efeitos dessa forma de aplicação de insulina sobre as complicações crônicas do diabetes ainda não estão bem estabelecidos.Objective: The objective of this review was to evaluate the medical literature in the last ten years comparing the use of insulin pen injectors versus insulin syringes in children with type 1 diabetes. Sources: This is a review of literature in the last ten years based on Medline. Summary of the findings: The use of the insulin pen injector is disseminated all over the world. Most studies show that this method is more comfortable and makes patients’ life easier. It is associated to better glycemic control, it is more easily accepted and is related to the reduction of hypoglycemic crisis. The use of the insulin pen injector provided better quality of life to this group of patients. Conclusions: The new technology produces different methods of insulin administration trying to improve the quality of life

  8. Representações sociais do pé diabético para pessoas com diabetes mellitus tipo 2 Representaciones sociales del pie diabético para personas con diabetes mellitus tipo 2 Social representations of diabetic foot for people with type 2 diabetes Mellitus

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    Maria Seloi Coelho

    2009-03-01

    Full Text Available Trata-se de uma pesquisa qualitativa que objetivou compreender as representações sociais do pé diabético para pessoas com diabetes mellitus tipo 2. Foram realizadas entrevistas semi-estruturadas, com dez pessoas com diabetes mellitus que participavam de um grupo de convivência. Da análise de conteúdo emergiram duas categorias: a doença do pé com alterações percebidas e ameaças presentes e; o cuidado com os pés, com o cuidado como preocupação com o futuro e não cuidado como sentimento de culpa. Os resultados mostraram que movidos pelas representações de alterações e ameaças os sujeitos buscam no cuidado uma esperança de não desenvolver a doença do pé ou controlar a situação. Quando o não-cuidado ocorre, surge o sentimento de culpa por terem conhecimentos e não se cuidarem. As representações sociais contribuíram na busca da compreensão do modo como os sujeitos com diabetes mellitus constroem saberes que expressam sua identidade e guiam seus comportamentos, especialmente vinculado ao pé diabético.Se trata de una investigación cualitativa que tuvo como objetivo comprender las representaciones sociales de pies diabético para personas con diabetes mellitus tipo 2. Fueron realizadas entrevistas semi-estructuradas, con diez personas con diabetes mellitus que participaban de un grupo de convivencia. Del análisis de contenido emergieron dos categorías: la enfermedad del pie con alteraciones percibidas y amenazas presentes y; el cuidado con los pies, con el cuidado como preocupación con el futuro y no cuidado como sentimiento de culpa. Los resultados mostraron que movidos por las representaciones de alteraciones y amenazas los sujetos buscan en el cuidado una esperanza de no desarrollar la enfermedad del pie o de controlar la situación. Cuando ocurre el no cuidado surge el sentimiento de culpa por tener los conocimientos y no utilizarlos. Las representaciones sociales contribuyeron en la búsqueda de la comprensi

  9. Personas con diabetes mellitus tipo 2 y su capacidad de agencia de autocuidado, Cartagena Pessoas com diabete mellitus tipo 2 e sua capacidade de agência de autocuidado, Cartagena Patients with Type 2 Mellitus Diabetes and their Self-Care Agency Capacity, Cartagena

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    Arleth Herrera Lían

    2012-07-01

    Full Text Available Contexto: La diabetes mellitus tipo 2 se constituye en un problema de salud pública por las repercusiones bio-psicosociales, la presencia de complicaciones neurovasculares y metabólicas en la persona que la padece. Enfermería cumple un papel importante a través de la educación y la capacitación. Objetivo: Identificar la capacidad de agencia de autocuidado de las personas con diagnóstico de diabetes mellitus tipo 2, inscritos en los programas de control de diabetes en 19 UPAS de Cartagena. Metodología: diseño descriptivo con abordaje cuantitativo, en una muestra de 225 adultos de ambos sexos, seleccionados en forma aleatoria. La capacidad de agencia de autocuidado se identificó con la escala de Valoración de las capacidades de autocuidado, desarrollada por Isenberg y Everest, traducida al español por Gallegos y adaptada por la Universidad Nacional de Colombia. Para presentar los datos se utilizó la estadística descriptiva, los resultados se presentan en tablas y gráficas. Resultados: Predominó el sexo femenino (68,4 %; la unión libre (59,1 %; escolaridad (50,6 % con básica primaria; bajos ingresos económicos (menos de un salario mínimo mensual vigente, 34.7 %. Al valorar la capacidad de agencia de autocuidado, el 73.8 % de los pacientes obtuvo una calificación de muy buena (76-100 %, según escala. Al valorar los aspectos comprendidos en la escala se encontró que más del 50 % de las personas siempre sacan tiempo para ellos, piden explicación sobre su salud, examinan su cuerpo para ver si hay cambios y conservan un ambiente limpio. Conclusiones: El apoyo social recibido por los pacientes con diabetes mellitus tipo 2 y las prácticas de higiene personal y del entorno, el conocimiento y la adherencia a la dieta, permiten a los pacientes una buena capacidad de agencia de autocuidado.Contexto: A diabete mellitus tipo 2 se configura como um problema de saúde pública por conta das repercussões biopsicossociais e da presen

  10. Guía colombiana de práctica clínica para el tratamiento de la diabetes mellitus tipo 2: falla al tratamiento inicial

    OpenAIRE

    Aschner Montoya, Pablo; Hospital Universitario San Ignacio-Pontificia Universidad Javeriana; Muñoz Velandía, Óscar Mauricio; Hospital Universitario San Ignacio, Pontificia Universidad Javeriana; Girón Cardozo, Diana Marcela; Pontificia Universidad Javeriana; García Morales, Olga Milena; Hospital Universitario San Ignacio-Pontificia Universidad Javeriana; Fernández Ávila, Daniel Gerardo; Hospital Universitario San Ignacio-Pontificia Universidad Javeriana; Casas, Luz Ángela; Asociación Colombiana de Endocrinología, Universidad del Valle; Casas, Luz Ángela; Asociación Colombiana de Endocrinología, Universidad del Valle; Arango Toro, Clara Maria; Asociación Colombiana de Endocrinología, Universidad del Valle, Cali, Colombia; Bohórquez Villamizar, Luisa Fernanda; Universidad Nacional de Colombia.; Arango Toro, Clara María; Universidad de Antioquia; Carvajal Gutiérrez, Liliana; Asociación Colombiana de Diabetes; Ramírez De Peña, Doris Amanda; Universidad Nacional de Colombia; Sarmiento, Juan Guillermo; Médico, especialista en Medicina Interna, fellow de Endocrinología, Hospital Universitario San Ignacio, Bogotá, Colombia. Experto temático.; Colón, Cristian Alejandro; Médico, especialista en Medicina Interna, fellow de Endocrinología, Hospital Universitario San Ignacio, Bogotá, Colombia. Experto temático.; Correa González, Nestor Fabian; Pontificia Universidad Javeriana-Hospital Universitario San Ignacio Bogotá

    2017-01-01

    ResumenIntroducción: Existen diferentes opciones de manejo para pacientes con diabetes mellitus tipo 2 (DMT2) que ya iniciaron tratamiento farmacológico con metformina y no han alcanzado metas de control glucémico. Resulta prioritario definir pautas para escoger la mejor opción en estos pacientes, así como en aquellos que no han tenido un control óptimo con la combinación de dos medicamentos. Objetivo: Definir cuál es antidiabético de elección, entre sulfonilureas, tiazolidinedionas, inhibido...

  11. Avaliação das ações educativas na promoção do autogerenciamento dos cuidados em diabetes mellitus tipo 2

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    Torres, Heloísa de Carvalho; Pereira, Flávia Rodrigues Lobo; Alexandre, Luciana Rodrigues

    2011-01-01

    O estudo visa avaliar as ações educativas na promoção do autogerenciamento dos cuidados em diabetes mellitus. Vinte e sete indivíduos com diabetes tipo 2, atendidos no programa educativo do hospital-escola de Belo Horizonte, Minas Gerais, foram acompanhados durante quatro meses no ano de 2008. As ações educativas nos grupos consistiam de três encontros mensais, nos quais eram desenvolvidas dinâmicas lúdicas e interativas, e o atendimento individual realizado por meio da educação dialógica. A ...

  12. A microbiota intestinal de doentes jovens com diabetes Mellitus tipo 1: uma abordagem proteómica e metabolómica

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    Ova, Adélia Cristina Bravo Brito de Abreu

    2013-01-01

    Dissertação de mest., Ciências Biomédicas, Faculdade de Ciências e Tecnologia, Univ. do Algarve, 2013 O trato gastrointestinal do ser humano é colonizado por vários microrganismos; bactérias, arquebactérias, fungos e vírus. As alterações, quer na composição da microbiota quer na sua funcionalidade provocam um desequilíbrio designado por disbiose, Em situações de doenças crónicas e permanentes como é o caso da diabetes mellitus tipo 1, o conhecimento que se possui sobre a compos...

  13. Asociación entre el déficit de vitamina D y bienestar emocional en pacientes con Diabetes Mellitus tipo 1

    OpenAIRE

    Waselle Vallina, Rebeca

    2016-01-01

    Introducción: La deficiencia de vitamina D se asocia con un mayor riesgo de padecer enfermedades autoinmunes, como sería el caso de los pacientes con diabetes mellitus tipo 1. Esta enfermedad tiene un impacto, sobre la calidad de vida y el bienestar emocional de los pacientes, relacionado con el control glucémico, las complicaciones y algunas variables socioeconómicas. Objetivos: El objetivo principal fue evaluar el grado de asociación entre la vitamina D y el bienestar emocional de los ...

  14. Therapeutic itinerary of the family and adolescent with type i mellitus diabetes El itinerario terapéutico del adolescente con diabetes mellitus tipo i y sus familiares Itinerário terapêutico do adolescente com diabetes mellitus tipo 1 e seus familiares

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    Mariza Maria Serafim Mattosinho

    2007-12-01

    Full Text Available This is a qualitative assistential convergent study. Its main objective is to understand the therapeutic itinerary of adolescents with type 1 mellitus diabetes, as well as that of their families. The sample was composed of adolescents, between 15 and 25 years old, involved with a health institution in Florianópolis through the Health Care model that includes professional, family, and popular subsystems. Data were obtained through in-depth interviews and field observation of 20 people (relatives and adolescents with diabetes. The data analysis included data codification and categorization. Two categories were constructed: Decisions and negotiations about health, care and treatment; and the journey through the three subsystems of health care. The study permitted to understand that the treatment and care within the professional subsystem are not the only ones available. There are different practices in health performed from the evaluation each family makes, of what they believe adequate for their adolescent with diabetes.Estudio de naturaleza cualitativa, de tipo convergente-asistencial, tuvo como objetivo comprender el camino terapéutico de los adolescentes con diabetes mellitus tipo I y sus familiares, vinculados a una institución de salud de Florianópolis, entre las edades de 15 y 25 años, a través del modelo del Cuidado para la Salud, que incluye los subsistemas profesional, familiar y popular. Los datos fueron obtenidos a través de la entrevista en profundidad y la observación de campo con 20 personas (familiares y adolescentes con diabetes. El análisis incluye la codificación y la categorización de los datos. Fueron construidos dos categorias: Las decisiones y negociaciones sobre la salud, los cuidados y los tratamientos y El percurso en los tres subsistemas de la salud. El estudio permitió comprender que los tratamientos y los cuidados del subsistema profesional no son los únicos, existiendo diferentes prácticas en la salud que

  15. Type II diabetes mellitus and the incidence of epithelial ovarian cancer in the cancer prevention study-II nutrition cohort.

    Science.gov (United States)

    Gapstur, Susan M; Patel, Alpa V; Diver, W Ryan; Hildebrand, Janet S; Gaudet, Mia M; Jacobs, Eric J; Campbell, Peter T

    2012-11-01

    Despite consistent associations of type II diabetes mellitus with hormonally related cancers such as breast and endometrium, the relation between type II diabetes mellitus and ovarian cancer risk is unclear. Associations of type II diabetes mellitus status, duration, and insulin use with epithelial ovarian cancer overall, and with serous and nonserous histologic subtypes were examined in the Cancer Prevention Study-II Nutrition Cohort, a prospective study of U.S. men and women predominantly aged 50 years and older. Between 1992 and 2007, 524 incident epithelial ovarian cancer cases were identified among 63,440 postmenopausal women. Multivariable-adjusted relative risks (RR) and 95% confidence intervals (CI) were computed using extended Cox regression to update diabetes status and bilateral oophorectomy status during follow-up. Type II diabetes mellitus status (RR = 1.05; 95% CI, 0.75-1.46) and duration were not associated with epithelial ovarian cancer risk. Although not statistically significantly different (P(difference) = 0.39), the RR was higher for type II diabetes mellitus with insulin use (RR = 1.28; 95% CI, 0.74-2.24) than for type II diabetes mellitus without insulin use (RR = 0.96; 95% CI, 0.64-1.43). Diabetes seemed to be more strongly associated with nonserous (RR = 1.41; 95% CI, 0.70-2.85) than serous (RR = 0.71; 95% CI, 0.41-1.23) histologic subtypes. Type II diabetes mellitus was not associated with risk of epithelial ovarian cancer, although higher risks with nonserous subtypes and among insulin users cannot be ruled out. Larger studies are needed to clarify associations of type II diabetes mellitus with or without insulin use with risk of ovarian cancer overall and by histologic subtypes. ©2012 AACR.

  16. Alimentación de niños con diabetes mellitus tipo 1 con respecto a las recomendaciones

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    San Martín Jiménez, Rocío

    2014-01-01

    Introducción: La diabetes tipo 1 es una enfermedad crónica prevalente en la infancia, siendo unos de los pilares fundamentales de su tratamiento la alimentación. Diseñamos un estudio para valorar el grado de cumplimiento de las recomendaciones nutricionales de los pacientes pediátricos con diabetes tipo 1. Diseño y métodos. Estudio observacional transversal de 50 niños y adolescentes con diabetes tipo 1, que acuden al Hospital Clínico Universitario de Valladolid. La ingesta fue recogida me...

  17. Estimativa do risco para diabetes mellitus tipo 2 em bancários da cidade de Tubarão, estado de Santa Catarina, Brasil = Assessing the risk for type 2 diabetes mellitus in bank employees from the city of Tubarao, Santa Catarina state, Brazil

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    Bittencourt, Amanda

    2013-01-01

    Conclusões: Os bancários da cidade de Tubarão apresentam risco de desenvolver diabetes mellitus tipo 2 em 10 anos e esse risco tende a aumentar quanto maior o tempo nesta profissão. Medidas preventivas são necessárias para melhora da qualidade de vida desses funcionários, bem como redução do risco de desenvolvimento de diabetes mellitus tipo 2

  18. Propiedades psicométricas de la Escala de Locus de Control de la Salud en Dios en una muestra de mexicanos con diabetes mellitus tipo 2

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    Vianey Guadalupe Argüelles Nava

    2017-12-01

    Full Text Available En este estudio se obtuvo evidencia de validez y confiabilidad de la escala de Locus de Control de la Salud en Dios (GLHC en una muestra de 539 adultos mexicanos con diabetes mellitus tipo 2. El análisis de validez se basó en el análisis del contenido de los ítems y de la estructura interna del GLHC. El primer procedimiento estuvo a cargo de seis expertos, quienes evaluaron la pertinencia de la adaptación de los ítems. El segundo procedimiento fue un análisis factorial confirmatorio de grupo múltiple, de acuerdo al sexo y edad, a fin de evaluar la invarianza de medición del GLHC. Finalmente, la confiabilidad fue calculada mediante los coeficientes ω y H. El análisis factorial confirmatorio demostró una estructura de un solo factor con seis ítems, interpretable para la población de estudio con invarianza de medición por sexo, aunque deben tomarse precauciones al interpretar comparaciones por grupos de edad. La confiabilidad del constructo obtuvo magnitudes elevadas (>.90. Los resultados indican que la GLHC puede brindar información válida y confiable para valorar el locus de control de la salud en Dios para mexicanos con diabetes mellitus tipo 2.

  19. Elevada frecuencia de neuropatía periférica en pacientes con Diabetes mellitus tipo 2 de un hospital general de Lima-Perú

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    Ray Ticse

    2013-04-01

    Full Text Available Objetivos: Determinar la frecuencia de neuropatía periférica en pacientes con diabetes mellitus tipo 2 y la correlación entre la evaluación clínica con el estudio de la velocidad de conducción nerviosa (VCN. Material y métodos: Estudio descriptivo, transversal. Se evaluaron 62 pacientes con diagnóstico de diabetes mellitus tipo 2. Se utilizó el Michigan Neuropathy Screening Instrument (MNSI, el Michigan Diabetic Neuropatic Score (MDNS y el estudio de VCN. Además se describieron las variables demográficas, antropométricas y de laboratorio. Resultados: La frecuencia de neuropatía periférica fue 96,8% según la VCN y 45% según el MNSI. La correlación entre el número de nervios afectados según VCN y el score MDNS fue moderada (Spearman r=0,59; p<0,001. Conclusiones: Existe una elevada frecuencia de neuropatía periférica en los pacientes diabéticos evaluados y no hubo buena correlación entre VCN y el score MDNS.

  20. Cost-of-illness study of type 2 diabetes mellitus in Colombia Diabetes mellitus tipo 2 en Colombia: costo de la enfermedad

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    Juan Camilo González

    2009-07-01

    , total y por paciente, de la diabetes mellitus tipo 2 (DM2 en Colombia desde las perspectivas de la sociedad y del Ministerio de Salud. MÉTODOS: A partir de la experiencia clínica de un endocrinólogo colombiano se adaptó para Colombia un modelo de transición de Markov ya publicado. Las probabilidades de transición para el modelo se tomaron de una revisión de la literatura internacional. Se elaboró un modelo para un horizonte temporal de 42 años. Se identificaron los recursos directos (por medicamentos, laboratorio, médicos, hospitalización y otros servicios de salud y se estableció su costo a partir de la lista nacional de precios, las directivas internacionales de atención, y otros estudios colombianos o de otros países. Los costos indirectos (tiempo de trabajo perdido se calculó mediante el enfoque de capital humano. Los costos directos e indirectos -tanto anuales como por toda la vida- se determinaron en dólares estadounidenses (US$ de 2007 con una tasa de descuento de 5%, tanto para un paciente como su proyección para toda la población colombiana. Los costos se agruparon según el tratamiento y el curso de la enfermedad. RESULTADOS: El costo estimado anual fue de US$ 2 700 millones desde la perspectiva de la sociedad y de US$ 921 millones desde la perspectiva del Ministerio de Salud. Los costos directos anuales por paciente fueron de US$ 288, mientras que los indirectos fueron US$ 559 (total = US$ 847. Estos costos se distribuyeron según el curso de la enfermedad de la siguiente manera: 47% por el tratamiento de la diabetes (medicamentos; 24% por enfermedades cardíacas y coronarias; 15% por accidentes cerebrovasculares; 9% por amputaciones; 3% por nefropatías; y 2% por retinopatías. Las complicaciones macrovasculares constituyeron 86% de los costos directos anuales y 95% de los indirectos. CONCLUSIONES: Se estimó el costo anual de la DM2 para Colombia según las perspectivas de la sociedad, el Ministerio de Salud y el Sistema de Salud de

  1. Lipoproteína (a está associada com níveis basais de insulina em pacientes com Diabetes Mellitus tipo 2 Lipoproteína (a está asociada a niveles basales de insulina en pacientes con Diabetes Mellitus tipo 2 Lipoprotein (a is associated with basal insulin levels in patients with type 2 Diabetes Mellitus

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    Syed Shahid Habib

    2009-07-01

    Full Text Available FUNDAMENTO: Ainda não foi claramente estabelecido se a resistência/deficiência insulínica leva diretamente à aterogênese ou através de sua associação com outros fatores de risco como os níveis de lipoproteína (a[Lp(a]. OBJETIVO: O objetivo do estudo foi estabelecer a relação entre os níveis basais de insulina, lípides e lipoproteína (a em pacientes com diabetes mellitus (DM tipo 2. MÉTODOS: Amostras de sangue foram colhidas em jejum e os níveis de insulina, lipoproteína (a, colesterol total (CT, triglicérides (TG, lipoproteína de baixa densidade (LDL-C, lipoproteína de alta densidade (LDL-C, glicose e hemoglobina glicada (HbA1c foram medidos em 60 pacientes com DM tipo 2 e 28 indivíduos saudáveis. Nós dividimos os pacientes em dois grupos baseados nos níveis basais de insulina: > 10 µIU/ml e 10 µIU/ml comparados com aqueles que apresentavam insulina basal FUNDAMENTO: Todavía no se aclaró totalmente si la resistencia/deficiencia insulínica lleva directamente a la aterogénesis o a través de su asociación con otros factores de riesgo como los niveles de lipoproteína (a [Lp(a]. OBJETIVO: : El objetivo del estudio fue establecer la relación entre los niveles basales de insulina, lípidos y lipoproteína (a en pacientes con diabetes mellitus (DM tipo 2. MÉTODOS: Se extrajeron muestras de sangre en ayuno y se determinaron los niveles de insulina, lipoproteína (a, colesterol total (CT, triglicéridos (TG, lipoproteína de baja densidad (LDL-C, lipoproteína de alta densidad (LDL-C, glucosa y hemoglobina glicosilada (HbA1c en 60 pacientes con DM tipo 2 y 28 individuos sanos. Dividimos a los pacientes en dos grupos basados en los niveles basales de insulina: > 10 µIU/ml y 10 µIU/ml comparados con aquellos que presentaban insulina basal BACKGROUND: It has not been clearly established whether insulin resistance/deficiency leads directly to atherogenesis or through its association with other risk factors such as

  2. Papel de la testosterona y el cortisol en el síndrome metabólico y la diabetes mellitus tipo 2 Role of testosterone and cortisol in metabolic syndrome and type 2 diabetes mellitus

    OpenAIRE

    Aimée M. Álvarez Álvarez; Roberto M. González Suárez; Miguel A. Marrero Falcón

    2010-01-01

    INTRODUCCIÓN: el síndrome metabólico y la diabetes mellitus tipo 2 son trastornos metabólicos que han sido ampliamente abordados en la literatura científica por su alta incidencia, así como la alta morbilidad y mortalidad que a ellos se asocia. En los últimos años se han explorado nuevos elementos de posible impacto en su fisiopatogenia, dentro de los que se destacan los esteroides sexuales y los glucocorticoides. En este trabajo se revisaron y comentaron los conocimientos más actuales sobre ...

  3. Resultados de un seguimiento educativo a personas con diabetes mellitus tipo 2 y sobrepeso u obesidad Results of educational follow-up of persons with type 2 diabetes mellitus and overweight/obesity

    OpenAIRE

    Rosario García; Rolando Suárez

    2003-01-01

    El presente trabajo muestra los resultados de un seguimiento educativo a personas con diabetes mellitus tipo 2 y sobrepeso corporal u obesidad, realizado como continuidad del estudio latinoamericano PEDNID-LA, con el objetivo de evaluar, en forma prospectiva, los cambios clínicos, bioquímicos y terapéuticos obtenidos después de participar en un programa de educación grupal con metodología interactiva. El estudio incluyó 40 pacientes no insulino dependientes, obesos o en sobrepeso y preferente...

  4. Biomecánica del pié diabético: estudio experimental de pacientes con Diabetes Mellitus Tipo I con y sin neuropatía periférica

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    Pérez Verdún, Miguel Ángel

    2014-01-01

    La prevalencia de pacientes con diabetes mellitus tipo I en España supone del 10 al 15% del total de los pacientes con diabetes. Algunos estudios apoyan la correlación entre alteraciones biomecánicas del pie y el desarrollo neuropático en diabetes. Objetivo Principal: Relacionar las alteraciones biomecánicas del pie con la presencia de neuropatía periférica de miembros inferiores en pacientes con diabetes mellitus tipo 1. Objetivos secundarios: Conocer los patrones de presión plantar, sup...

  5. Prevalencia de cardiopatía isquémica asintomática en pacientes con diabetes mellitus tipo 2

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    Dulman O. Pineda-De Paz

    2018-03-01

    Full Text Available Resumen: Introducción: La enfermedad cardiovascular es la causa principal de muerte en pacientes con diabetes mellitus. La prevalencia de cardiopatía isquémica asintomática es más alta en pacientes diabéticos que en no diabéticos y se asocia a peor pronóstico. Objetivo: Identificar la prevalencia de cardiopatía isquémica asintomática en pacientes con diabetes mellitus tipo 2 en un hospital de tercer nivel de atención de Guatemala y analizar la posible asociación de dicha enfermedad con características epidemiológicas, clínicas y metabólicas. Métodos: Estudio de corte transversal en el que se estudió una muestra de 92 pacientes diabéticos seleccionados de forma aleatoria simple. Se realizó electrocardiograma, que cuando fue negativo para isquemia ameritó prueba de esfuerzo, o de lo contrario, ecocardiograma de estrés con dobutamina. Resultados: La edad media de los participantes fue de 57 años, 88% de los cuales eran mujeres; la duración media de la diabetes fue 7 años. Se encontró cardiopatía isquémica asintomática en el 22,8% de los casos. No se hallaron posibles asociaciones entre cardiopatía isquémica asintomática y edad, sexo, enfermedad arterial periférica, índice de masa corporal, índice tobillo-brazo, hipertensión arterial, dislipidemia, tabaquismo activo, sedentarismo, sobrepeso/obesidad, alcoholismo, glucosa en ayunas, hemoglobina glicosilada, colesterol total, colesterol HDL, colesterol LDL, ácido úrico, creatinina, tasa de filtrado glomerular y microalbuminuria. Conclusiones: La prevalencia de cardiopatía isquémica asintomática en la población estudiada con diabetes mellitus tipo 2 fue de 22,8%. No se encontraron posibles asociaciones de cardiopatía isquémica asintomática con las variables estudiadas. Abstract: Introduction: Cardiovascular disease is the main cause of death in patients with diabetes mellitus. The prevalence of asymptomatic ischaemic heart disease is higher in diabetic

  6. Depressão, cortisol urinário e perfil sócio-demográfico de portadores de diabetes mellitus tipo 2 Depresion, el cortisol urinario y perfil sociodemografico em portadores de diabetes mellitus tipo 2 Depression, urinary cortisol and social demographics characteristics in subjects with type 2 diabetes mellitus

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    Alexandra Bulgarelli do Nascimento

    2009-12-01

    Full Text Available O objetivo deste estudo foi investigar a relação entre indicadores de depressão e perfil sócio-demográfico de portadores de Diabetes Mellitus tipo 2 (DM2.A avaliação sócio-demográfica foi conduzida em amostra composta por 40 pacientes na Liga de Diabetes (HC-FMUSP.Os indicadores de depressão foram investigados a partir do Inventário de Depressão de Beck (IBD em associação com cortisol urinário (CORT.Os resultados mostraram que indivíduos portadores de DM2 com alta escolaridade, baixo poder aquisitivo individual e familiar e com história de rompimento de relação conjugal estável estão mais propensos a sintomas de depressão.Lo objective deste estudo fue investigar la relación entre la depresión y los indicadores de perfil socio-demográfico de los pacientes con diabetes mellitus tipo 2 (DM2. Evaluación socio-demográficos se llevó a cabo en una muestra de 40 pacientes en la Liga de la Diabetes (HC-FMUSP. Indicadores de la depresión se han investigado en el Beck Depression Inventory (BDI,en asociación con el cortisol urinario (CORT.Resultados muestraron que los pacientes con DM2 con alto nivel de educación,las personas de bajos ingresos y familias con historia de interrupción de los matrimonios estables son más propensos a tener síntomas de la depresión.The objective this study was investigate the relationship between depression indicators and social-demographics characteristics in subjects with Type 2 Diabetes Mellitus (DM2. The socio-demographic evaluation was conducted in a sample composed of 40 patients with DM2 from Diabetes League (HCFM-USP.Depression indicators were evaluated through the Beck Depression Inventory (BDI in addition to urinary cortisol (CORT.The results showed that individuals with high education level,poor individual and familiar economic status in addition to history of broken stable relationship are more likely to depressive symptoms.

  7. Contribución de la interacción del genoma y el ambiente en la aparición de la diabetes mellitus tipo 2

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    Reinaldo Menéndez García

    2015-06-01

    Full Text Available Introducción: la diabetes mellitus agrava el pronóstico de las tres primeras causas de muerte en Cuba. La tasa en Pinar del Río es de 4.3 x 100 000 habitantes y su prevalencia de 29.6 x 1000 habitantes. Objetivo: determinar el papel de la interacción genoma-ambiente, el nivel de conocimiento de las complicaciones y el grado de percepción de riesgo, en la ocurrencia de la diabetes mellitus tipo 2, para proponer una estrategia preventiva-educativa de la enfermedad. Material y método: se realizó un estudio de casos y controles de base poblacional en el Policlínico universitario "Raúl Sánchez". El universo estuvo constituido por 87 individuos diabéticos tipo 2 y la muestra por 60 casos y 120 controles, en una proporción 1:2, apareados por edad, sexo biológico y zona geográfica. Se utilizó ji cuadrado de Pearson para determinar la asociación y Odds Ratio para medir magnitud. Se realizó un estudio de interacción genoma-ambiente con modelos multiplicativo y aditivo. Resultados: el riesgo de padecer la enfermedad aumenta 10.83 veces cuando interactúa el factor genético familiar de primer grado afectado y el factor ambiental obesidad y 5.75 veces cuando interactúa con dieta rica en grasa. Predomina la vía parental materna. El 66.0% de los enfermos conocen las complicaciones de la enfermedad, y 61.7% de los pacientes sanos tienen una adecuada percepción del riesgo de contraerla. Conclusiones: la obesidad, dieta rica en grasas y sedentarismo modulan la predisposición genética de padecer diabetes mellitus tipo 2. Mientras más genes se comparten, existe mayor predisposición genética; la interacción genoma-ambiente incrementa significativamente el riesgo.

  8. Diversidad y universalidad como respuesta a pie diabético en paciente paquistaní con diabetes mellitus tipo 2 desde Atención Primaria

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    Montserrat Brugada Faura

    Full Text Available Siguiendo las enseñanzas de Madeleine Leininger sobre los conceptos de su modelo transcultural, buscamos una respuesta en el entorno de la Atención Primaria al caso que nos ocupa de una lesión ulcerosa en pie izquierdo, de etiología desconocida, en paciente paquistaní con diabetes mellitus tipo 2. Hallando la respuesta mediante la adaptación de similitudes de riesgo en el entorno de esta enfermedad, comunes en todas las culturas, y cuyas diferencias estriban en la localización de la úlcera y su factor desencadenante. Anómalas en nuestra cultura al estar relacionada con sus prácticas culturales.

  9. Diabetes Mellitus: fatores de risco em uma instituição de ensino na área da saúde Los factores de riesgo para los Diabetes Mellitus tipo 2 de institución de enseñanza Type-2 Diabetes Mellitus: risk factors in a school in the health field

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    Maria Carolina Alves Ortiz

    2000-12-01

    Full Text Available O objetivo deste estudo é identificar os fatores de risco para o diabetes mellitus tipo 2. Os resultados indicam a necessidade de programa educativo junto às instituições, visando despertar nos sujeitos a busca de estilos de vida saudáveis a fim de prevenir os fatores de risco para o diabetes tipo 2.El objetivo del estudio es identificar los factores de riesgo para la diabetes mellitus de tipo 2. Los resultados muestran la necesidad de un programa educativo junto con las instituciones, buscando despertar en los sujetos la necesidad de buscar un estilo de vida saludable con el fin de prevenir los factores de riesgo para la diabetes tipo 2.This work aims at identifying the risks factors of type-2 diabetes mellitus. The results show the need of an education program in institutions aiming at making the subjects aware of the necessity to look for healthy life styles in order to prevent the risks factors of type-2 diabetes.

  10. EDUCAÇÃO EM SAÚDE A PORTADORES DE DIABETES MELLITUS TIPO 2: REVISÃO BIBLIOGRÁFICA

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    Ana Roberta Vilarouca da Silva

    2009-01-01

    Full Text Available La educación en salud posibilita capacitación y acciones transformadoras que favorecen el cambio de pensamientos y ac- ciones, bien aprovechado en las enfermedades crónicas, entre las cuales se destaca la Diabetes Mellitus tipo 2 (DM2. Así, el objetivo fue identificar las estrategias de educación en salud con énfasis en los portadores de DM2 implícitas en artículos dis- ponibles en los bancos de datos MEDLINE, LILACS, BDENF y SciELO, en el período de 1997 a 2007. Se utilizaron los descriptores “educación en salud” y “diabetes mellitus tipo2”, siendo seleccionados artículos disponibles por completo. Los datos fueron sintetizados en planilla y analizados según la literatura específica. Las estrategias utilizadas fueron: Educación interactiva, intervención educativa comunitaria, juegos en grupos operativos, seminarios educativos, acompañamiento periódico de los parámetros clínicos y bioquímicos, visitas domiciliarias, conferencias educativas, actividades prácticas sobre alimentación y ejercicio físico, exámenes médicos oftálmicos, relato de casos y colonia educativa. Se enfocó la adquisición de conocimien- to y auto-cuidado. Se sugiere la realización de estudios longitudinales apoyados en la concepción positiva de la salud.

  11. Creencias, actitudes y normas subjetivas como predictores de la intención de realizar comportamientos preventivos en hijos de personas que padecen diabetes mellitus tipo 2

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    Eduardo Muñoz Bautista

    2014-03-01

    Full Text Available Objetivo: Analizar los conocimientos, las actitudes y las normas subjetivas como predictores de la intención de realizar comportamientos preventivos en hijos de personas con diabetes mellitus tipo 2, en dos ciudades del estado de Hidalgo, México. Métodos: Se trata de um estudio cuantitativo, no experimental, de naturaleza analítica y transversal. A través de uma muestra probabilística de dos etapas, 246 hijos (entre 15 y 59 años de edad de pacientes apuntados en un programa de diabetes en el servicio de seguridad social fueron encuestados de manera personal. Resultados: Se observó que la reducción del riesgo de contraer diabetes afecta la intención de desarrollar comportamientos preventivos mediada por la actitud hacia la prevención (p=0,000 que es el predictor más importante de tal intención (p=0,000. Las normas subjetivas también tienen un impacto significativo en la intención del comportamiento preventivo (p=0,000, aunque la actitud hacia la prevención no es afectada por las creencias sobre la obtención (p=0,095 y la gravedad de la enfermedad (p=0,056. Conclusión: La aplicación del modelo permitió identificar aspectos relevantes para apoyar la promoción de la salud orientada a influir en los procesos de cambio de comportamiento social en uma población con el riesgo de contraer diabetes mellitus tipo 2 en México.

  12. Adaptación cultural al español y validación psicométrica del Summary of Diabetes Self-Care Activities measure (SDSCA en personas con diabetes mellitus tipo 2

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    Jorge Caro-Bautista

    2016-08-01

    Conclusiones: El SDSCA-Sp en una versión válida en la práctica clínica y en investigación para evaluar autocuidados en diabetes mellitus tipo 2 con propiedades clinimétricas similares a las obtenidas en estudios previos.

  13. Construcción y validación inicial de un instrumento para medir el estilo de vida en pacientes con diabetes mellitus tipo 2

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    López-Carmona Juan Manuel

    2003-01-01

    Full Text Available OBJETIVO: Construir y validar un instrumento específico para medir el estilo de vida en los pacientes con diabetes mellitus tipo 2. MATERIAL Y MÉTODOS: Entre marzo de 2001 y abril de 2002 se hizo un estudio observacional, longitudinal y prospectivo en unidades de medicina familiar de la delegación Estado de México Oriente, del Instituto Mexicano del Seguro Social. Se diseñó un instrumento de autoadministración, denominado instrumento para medir el estilo de vida en diabéticos, el cual fue sometido a revisión por un panel multidisciplinario de expertos para determinar su validez lógica y de contenido. Se aplicó el instrumento en dos días diferentes a 412 sujetos adultos con diabetes mellitus. Fueron depurados los ítems considerando la frecuencia de selección de sus opciones de respuesta, su correlación ítem-total y su carga significativa en los dominios durante el análisis factorial. RESULTADOS: Completaron el estudio 389 (94.7% sujetos. Los coeficientes de correlación intra-clase para la validez lógica y de contenido fueron de 0.91 y 0.95, respectivamente. Después de la depuración de ítems se obtuvo un instrumento conformado por 25 preguntas cerradas, distribuidas en siete dominios: nutrición, actividad física, consumo de tabaco, consumo de alcohol, información sobre diabetes, emociones y adherencia terapéutica. El a de Cronbach para la calificación total fue de 0.81 y el coeficiente de correlación test-retest de 0.84. CONCLUSIONES: El instrumento para medir el estilo de vida en diabéticos es el primer cuestionario específico para sujetos con diabetes mellitus tipo 2 y tiene validez aparente, validez de contenido y buen nivel de consistencia.

  14. Efecto de la suplementación con Vimang® sobre indicadores de estrés oxidativo en jóvenes con diabetes mellitus tipo 1 Effect of Vimang® supplementation on oxidative stress markers in young patients with type 1 diabetes mellitus

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    Adrián Luis Escobar Aedo

    2011-08-01

    Full Text Available Introducción: el estrés oxidativo juega un papel fundamental en la fisiopatogenia de las complicaciones de la diabetes mellitus. Se ha empleado con éxito el producto natural antioxidante Vimang® en enfermedades caracterizadas por incremento del estrés oxidativo. Objetivo: evaluar el efecto del Vimang® sobre el estado redox, en personas jóvenes con diabetes mellitus tipo 1. Métodos: se realizó un ensayo clínico fase II, unicéntrico, aleatorizado y controlado, en el que se evaluó la eficacia antioxidante del Vimang® en tabletas, en jóvenes con diabetes mellitus tipo 1. Fueron incluidos 50 pacientes, que se distribuyeron en 2 grupos de 25 cada uno, que recibieron Vimang® en tabletas de 300 mg cada 8 h y placebo, respectivamente. Se evaluó el control glucémico a través de la hemoglobina glucosilada, se realizó un lipidograma completo y determinaciones hemoquímicas. Fueron evaluadas las variables de daño por estrés oxidativo: potencial de peroxidación, hidroperóxidos totales, productos avanzados de la oxidación de proteínas, malonilaldehído y del antioxidante endógeno glutatión reducido. Las determinaciones se realizaron antes, y a los 3 meses de la intervención. Los grupos fueron comparados entre sí, en los dos tiempos, así como internamente con respecto al estado basal previo a la suplementación con Vimang® o placebo. Resultados: el potencial de peroxidación se incrementó a los 3 meses en ambos grupos (pIntroduction: the oxidative stress plays a fundamental role in the pathogenesis of diabetes mellitus complications. Vimang® (a natural antioxidant product has been successfully used diseases characterized by an increase of oxidative stress. Objective: to assess the effect of Vimang® on the redox state in young people presenting with type 1 diabetes mellitus. Methods: a phase II clinical, randomized, controlled unicenter trial to assess the antioxidant effectiveness tablets Vimang® in young people with type 1

  15. ESTILO DE VIDA Y ADHERENCIA AL TRATAMIENTO DE LA POBLACIÓN CANARIA CON DIABETES MELLITUS TIPO 2

    OpenAIRE

    Antonio Cabrera de León; José Carlos del Castillo Rodríguez; Santiago Domínguez Coello; María del Cristo Rodríguez Pérez; Buenaventura Brito Díaz; Carlos Borges Álamo; Lourdes Carrillo Fernández; Delia Almeida González; José Juan Alemán Sánchez; Ana González Hernández; Armando Aguirre-Jaime

    2009-01-01

    Fundamento: la población canaria sufre la mayor mortalidad por diabetes tipo 2 (DM2) en España. El objetivo de este estudio es conocer el estilo de vida de las personas diabéticas del archipiélago y su adherencia al tratamiento, así como la DM2 desconocida. Métodos: estudio transversal de 6.729 personas de la población general participantes en la cohorte "CDC de Canarias" (edad 18-75 años). Se obtuvieron sus antecedentes médicos, dieta, actividad física, medicamentos consumidos, tabaco, etc. ...

  16. Asociación de la microalbuminuria con la disfunción ventricular izquierda en personas normotensas con diabetes mellitus tipo 1 Microalbuminuria and its association with left ventricular dysfunction in normotensive subjects presenting with type 1 diabetes mellitus

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    Manuel Emiliano Licea Puig

    2009-04-01

    Full Text Available ANTECEDENTES: la disfunción ventricular izquierda es una complicación frecuente en las personas con diabetes mellitus 1. OBJETIVO: determinar si la excreción urinaria de albúmina se asocia a la presencia de disfunción ventricular izquierda en personas normotensas con diabetes mellitus 1 de largo tiempo de evolución. MÉTODOS: se realizó un estudio transversal y descriptivo en 80 diabéticos normotensos tipo 1 con 10 años o más de evolución de la diabetes mellitus 1, atendidos consecutivamente en nuestro centro, en edades entre los 15 y los 40 años. Se excluyeron otras enfermedades o condiciones que provoquen por sí mismas disfunción ventricular izquierda y proteinuria. Se estudió: edad, sexo, índice de masa corporal, hábito de fumar, presión arterial, evolución de la diabetes mellitus 1, retinopatía diabética, nefropatía diabética incipiente, glucemia en ayunas y posprandial de 2 h, hemoglobina glucosilada (HbA1, excreción urinaria de albúmina de 24 h, creatinina, electrocardiograma y ecocardiograma modo M bidimensional con Doppler pulsado. RESULTADOS: se comprobó disfunción ventricular izquierda en el 26,3 % y alteraciones estructurales en el 16,2. La frecuencia de nefropatía diabética incipiente fue mayor (pBACKGROUNDS: left ventricular dysfunction is a frequent complication in persons presenting with type 1 diabetes mellitus. OBJECTIVE: to determine if albumin urinary excretion is associated with the presence of left ventricular dysfunction (LVD in normotensive persons presenting with type diabetes mellitus of a long evolution. METHODS: we made a descriptive and cross-sectional study in 80 normotensive type 1 diabetic patients aged between 15 and 40 with a ³10 years of type 1 diabetes mellitus evolution seen in a consecutive way in our service. Other diseases were excluded or those conditions provoking per se left ventricular dysfunction and proteinuria. Study includes: age, sex, body mass index (BMI, smoking

  17. Women with type 2 diabetes mellitus: sociodemographic profile, biometrics and health Mujeres con Diabetes mellitus tipo 2: perfil sociodemográfico, biométrico y de salud Mulheres com Diabetes mellitus tipo 2: perfil sociodemográfico, biométrico e de saúde

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    Juliana Cristina Lessmann

    2012-01-01

    Full Text Available OBJECTIVE: To understand the profile of women with type 2 diabetes mellitus, focusing on sociodemographic factors, biometrics and health. METHODS: A quantitative, transversal, prospective study with a stratified random sample, conducted in Florianópolis/SC with 147 women by means of home visits between April and August of 2009. RESULTS: The women had a mean age of 66 years, presented elevated indexes of body weight, capillary glycemia and abdominal circumference, along with a low adherence to non-pharmacological treatment. A low educational level was associated with inadequate glycemic control, no physical activity, and inadequacy of the diet. CONCLUSIONS: Women with lower education constitute a vulnerable group and require health interventions congruent with their capacities of understanding and possibilities of adaptation to treatment.OBJETIVO: Conocer el perfil de mujeres con Diabetes mellitus tipo 2, enfocando factores sociodemográficos, biométricos y de salud. MÉTODOS: Estudio de abordaje cuantitativo, transversal, prospectivo realizado con una muestra estratificada aleatoria, desarrollado en Florianópolis/SC con 147 mujeres por medio de visitas domiciliarias entre abril y agosto del 2009. RESULTADOS: Las mujeres tenían edad promedio de 66 años, presentaron elevados índices de masa corporal, glicemia capilar y circunferencia abdominal, además de baja adhesión al tratamiento no medicamentoso. La baja escolaridad se asoció al control inadecuado de la glicemia, no realización de actividad física e inadecuación de la dieta. CONCLUSIONES: Las mujeres con baja escolaridad constituyen un grupo vulnerable y necesitan intervenciones en salud congruentes con sus capacidades de comprensión y posibilidades de adaptación al tratamiento.OBJETIVO: Conhecer o perfil de mulheres com Diabetes mellitus tipo 2, enfocando fatores sociodemográficos, biométricos e de saúde. MÉTODOS: Estudo de abordagem quantitativa, transversal, prospectivo

  18. The perspectives of Brazilian homemakers concerning living with type 2 diabetes mellitus La perspectiva de ama de casa brasileña sobre la vida con diabetes mellitus tipo 2 As perspectivas de donas de casa brasileiras sobre a sua experiência com diabetes mellitus tipo 2

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    Denise Maria Guerreiro Vieira da Silva

    2012-06-01

    Full Text Available The purpose of this study is to present an understanding of the experience of Brazilian homemakers with type 2 diabetes mellitus (DM2. A descriptive exploratory design was used and semi-structured interviews were conducted with 25 Brazilian homemakers concerning their experience. The interviews were recorded, transcribed, and the resulting text was analyzed using the sequential step method. Data converged to one dominant category, "constructing one's identity in the family context", which is comprised of three categories: gender differences; day-to-day concerns; and incongruity between knowledge and behavior related to DM2. These findings suggest that participants construct their identities within the family context and that their experience of living with DM2 is integral to their self-identification as wives and mothers. This, in turn, has implications for the design and implementation of programs to assist women in managing DM2 effectively.El propósito de este estudio es comprender la experiencia de las amas de casa brasileñas con la diabetes mellitus tipo 2 (DM2. Se empleo un abordaje exploratorio descriptivo, donde participaron de las entrevistas 25 amas de casa de Brasil acerca de su experiencia con el DM. Las entrevistas fueron grabadas, transcritas y el texto resultante se analizó mediante el método secuencial de cuatro etapas: aprensión, síntesis, teorización y transferencia. Los datos se reunieron en un tema dominante: "construyendo su identidad en el contexto familiar", que se compone de tres sub-temas: las diferencias de género, las preocupaciones del cotidiano y la incongruencia entre el conocimiento y el comportamiento relacionado con DM2. Estos hallazgos sugieren que los participantes construyen su propia identidad dentro del contexto familiar y que su experiencia de vivir con DM2 es parte integral de su identificación como esposas y madres. Esto, a su vez, tiene implicaciones para el planeamiento e implementación de

  19. Concepciones evolutivas acerca de la fabricación del dinero II: Los tipos de respuestas

    OpenAIRE

    Delval, Juan; Denegri Coria, Marianela

    2002-01-01

    En este artículo se profundiza en el análisis de los tipos de respuesta dados por los escolares ante cuestiones relativas al proceso de fabricación del dinero, teniendo en cuanta las diferencies en cuanto el nivel de complejidad de las respuestas aportadas por los sujetos de diferentes edades que fueron entrevistados. Ministerio de Ciencia y Tecnología (España) BSO2000-0064

  20. Diabetes mellitus de tipo I y púrpura trombocitopénica inmunitaria en una niña Diabetes mellitus type I and immune thrombocytopenic purpura in a girl

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    José Raúl Zaldívar Ochoa

    2009-02-01

    Full Text Available Se detalla el caso clínico de una paciente de 11 años de edad, con antecedentes de diabetes mellitus de tipo I, que comenzó a presentar manchas de color rojo oscuro en la piel (similares a moretones en brazos, frente y piernas desde hacía 3 meses. Fue ingresada en el Hospital Infantil Norte Docente de Santiago de Cuba y luego de ser tratada con prednisona e insulina, al quinto día de administrarle esteroides comenzaron a disminuir las lesiones hemorrágicas cutáneas y otras a desaparecer. Egresó con un plan terapéutico específico e indicaciones para seguimiento clínico en las respectivas consultas de hematología y endocrinología pediátricasThe clinical case of an 11 year-old patient, with a history of diabetes mellitus type I who began to present spots of dark red color in the skin (similar to contusions arms, forehead and legs for 3 months is detailed. She was admitted to the Northern Teaching Hospital from Santiago de Cuba and after being treated with prednisona and insulin, on the fifth day of treatment with steroids the skin hemorrhagic lesions began to decrease and others to disappear. She was discharged with a specific therapeutic plan and indications for clinical follow-up in the respective hematologic and pediatric Endocrinology visits.

  1. Factors associated with therapy noncompliance in type-2 diabetes patients Frecuencia y factores asociados al incumplimiento terapéutico en pacientes con diabetes mellitus tipo 2

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    Lizbeth Hernández-Ronquillo

    2003-06-01

    Full Text Available OBJECTIVE: To identify the frequency and factors associated with therapy noncompliance in type-2 diabetes mellitus patients. MATERIAL AND METHODS: A cross-sectional study was carried out in 79 patients with type-2 diabetes mellitus seen in major hospitals of Mexico City. Patients were visited at home, from March 1998 to August 1999, to measure compliance with prescribed therapy. Complying patients were defined as those taking at least 80% of their pills or 80% of their corresponding insulin dose. The degree of compliance with therapy components (diet, amount of exercise, and keeping appointments was measured. RESULTS: The average age of study subjects was 59 years (SD 11 years; 73% (n=58 were female subjects. The overall frequency of noncompliance was 39%. Noncompliance rates were: 62% for dietary recommendations, 85% for exercise, 17% for intake of oral hypoglycemic medication, 13% for insulin application, and 3% for appointment keeping. Hypertension plus obesity was the only factor significantly associated with noncompliance (OR 4.58, CI 95% 1.0, 22.4, p=0.02. CONCLUSIONS: The frequency of therapy noncompliance was very high, especially for diet and exercise.OBJETIVO: Identificar la frecuencia y factores asociados al incumplimiento terapéutico en pacientes con diabetes mellitus tipo 2. MATERIAL Y MÉTODOS: Se llevó a cabo un estudio transversal en cuatro clínicas y hospitales de la Ciudad de México, en 79 pacientes con diabetes mellitus tipo 2. Se recolectaron datos sobre el cumplimiento terapéutico, para lo cual se visitó el domicilio de los sujetos de estudio entre marzo de 1998 y agosto de 1999, con el fin de contar los medicamentos. Se definió cumplimiento cuando el paciente administró correctamente 80% de las pastillas o de la dosis de insulina que le correspondía. Se midió el grado de cumplimiento para cada una de las medidas terapéuticas (dieta, ejercicio y asistencia a citas. RESULTADOS: La edad promedio del grupo fue de 59

  2. Factores de riesgo asociados a la retinopatía diabética en pacientes diabéticos tipo II Risk factors associated with diabetic retinopathy in type II diabetic patients

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    Lisis Osorio Illas

    2006-02-01

    Full Text Available Se realizó un estudio observacional, analítico, retrospectivo tipo caso-control en el que se estudiaron 40 pacientes diagnosticados como diabéticos tipo II de 30 años o más remitidos a la consulta de Oftalmología de Upata, en el municipio Piar, Estado de Bolívar, en Venezuela, en el período comprendido entre abril y agosto del año 2005. Se establecieron como factores de riesgo entre las diferentes variables analizadas, la obesidad, la hipertensión arterial, el tiempo de evolución de 10 años y más de la diabetes mellitus, los antecedentes patológicos familiares y el perfil lípidico alterado. Se concluyó que un tiempo de evolución de la diabetes de 10 años o más y un perfil lípidico alterado incrementó el riesgo de desarrollar retinopatía diabética en un 5,7 y un 8,5 número de veces respectivamente, demostrándose asociación causal con una probabilidad estadística An observational, analytical, retrospective case-control study was conducted among 40 patients aged 30 or over diagnosed as type II diabetic patients that were referred to the Ophthalmology office of Upata, in Piar municipality, State of Bolivar, in Venezuela, from April to August 2005. Obesity, arterial hypertension, time of evolution of diabetes mellitus of 10 years and more, pathological family history and the altered lipid profile were established as risk factors among the different variables analyzed. It was concluded that a time of evolution of diabetes of 10 years or over and an altered lipid profile increased the risk for developing diabetic retinopathy in 5.7 and 8.5 times, respectively, showing a causal association with a statistical probability < 0.05.

  3. Emociones y salud. Un estudio en diabéticos tipo II

    OpenAIRE

    Veiga-Branco, Augusta; Baptista, Gorete

    2012-01-01

    En este trabajo se aborda el valor de la emoción desde una perspectiva de la prevención secundaria de la enfermedad: se estudia la relación entre la emoción para la auto-aceptación de una patología crónica como la diabetes mellitus. El estudio descriptivo correlacional, se realiza sobre una muestra de 57 diabéticos del norte de Portugal, a quien les fue aplicado un conjunto de Escalas de Auto-Aceptación de la enfermedad y su relación con contextos emocionales negativos: (depresión y sufrimien...

  4. Estudios de intervención dirigidos a disminuir el riesgo de padecer diabetes mellitus tipo 2 Intervention studies aimed at lowering the risk of type 2 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    José Luis Valenciaga Rodríguez

    2003-12-01

    Full Text Available Los estudios de intervención en población de riesgo, dirigidos a disminuir la frecuencia de la aparición de la diabetes mellitus tipo 2 (DM 2, son considerados orientadores para el enfoque del trabajo con esos pacientes. El objetivo del presente estudio es revisar los resultados de investigaciones dirigidas a disminuir el riesgo de padecer DM 2. Los sujetos estudiados presentaban alguna de las siguientes condiciones: glucosa alterada en ayunas (GAA o tolerancia a la glucosa alterada (TGA, antecedente personal de diabetes gestacional y síndrome metabólico. Se citan, entre otros, DPP (diabetes prevention program, DPS (diabetes prevention study, STOP-NIDDM (study to prevent non-insulin-dependent diabetes mellitus, Hiperglucemia en ayunas, DAISI (dutch acarbose intervention trial, Da Quing (estudio chino, TRIPOD (troglitazone In the prevention of diabetes, intervención, XENDOS (xenical in the prevention of diabetes in obese subjects, WOSCOPS (west of scotland coronary prevention study, EDIT (early diabetes intervención trial, NAVIGATOR (nateglinide and valsartan in impaired glucose tolerance outcomes research, DREAM (diabetes reduction assessment with ramipril and rosiglitazone medication. Estos consistían en cambios de estilo de vida (fundamentalmente ejercicios físicos sistemáticos y orientaciones nutricionales y/o intervenciones terapéuticas. Se concluye que en personas con 25 o más años de edad de ambos sexos, con riesgo de padecer DM 2, la adopción de un estilo de vida saludable logra disminuir el riesgo de padecer el síndrome diabético. En sujetos con alto riesgo de DM 2, los fármacos que reportan mejores y más consistentes resultados son el metformin y la acarbosa. Otros como la nateglidina, rosiglitazona, ramipril y valsartan, se están investigando actualmente.Intervention studies on population at risk aimed at lowering the frequency of occurrence of type 2 diabetes mellitus(DM2 are considered as guiding lines for the work

  5. Análise de contingências de um portador de diabetes mellitus tipo 2: estudo de caso Contingency analysis of a type 2 diabetes mellitus pacient: a case study

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    Camila Ribeiro Coelho

    2008-12-01

    Full Text Available O diabetes mellitus é uma doença crônica e o seu tratamento é altamente complexo. Pesquisas têm surgido com o objetivo de compreender as contribuições do estilo de vida e dos fatores comportamentais no desenvolvimento e no controle da doença. O presente estudo realizou uma análise de contingências dos comportamentos de adesão e de não-adesão ao tratamento, buscando, para isso, relações de dependência entre eventos comportamentais e ambientais, a partir de um estudo de caso único com uma paciente portadora de diabetes mellitus tipo 2. O procedimento adotado para a coleta de dados foi a caracterização dos comportamentos de acordo com as seguintes categorias: mensuração da glicemia, administração da insulina, controle da dieta e prática de exercício físico. Os resultados indicaram a prevalência de contingências aversivas e demonstraram a necessidade de se ensinar estratégias de autocontrole ao paciente, e regras por parte da equipe de saúde, que descrevam as contingências em operação no ambiente.Diabetes mellitus is a chronic disease wich requires a highly complex treatment. Researches have been done with the objective of understanding the role that life style and behavioral factors play on the onset and control of the disease. The present study aimed at analysing the contingencies involved in the behavior of adherence and non adherence to treatment of a type 2diabetes mellitus patient and the dependency relationship between behavioral and environmental variables in a single case study. The procedure adopted for data collection was the characterization of behaviors according to the following categories: glucemia measurement, insulin administration, diet control and the practice of physical exercise. Results indicate the prevalence of aversive contingencies and demonstrate the need of teaching the pacient self control strategies, and rules by the health team which describe the environmental contingencies in operation.

  6. Condições periodontais em portadores de diabetes mellitus tipo 2 atendidos na Universidade Federal da Paraíba = Periodontal conditions in carriers of diabetes mellitus type 2 assisted in the Federal University of Paraíba

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    Guimarães, Karis Barbosa

    2007-01-01

    Full Text Available Este estudo propôs avaliar as condições periodontais e sua relação com o diabetes mellitus, através da análise clínica do grau de comprometimento dos tecidos de proteção e sustentação dentários. Foram examinados 71 pacientes, de ambos os gêneros e na faixa etária de 31 a 90 anos, portadores de Diabetes Mellitus Tipo 2 atendidos na Clínica de Estomatologia e Hospital Universitário da Universidade Federal da Paraíba, João Pessoa/PB. O critério de exclusão da amostra foi definido pelo edentulismo total. O índice periodontal comunitário modificado (com análise total dos elementos dentais presentes na cavidade oral e o índice de perda de inserção periodontal determinaram as condições periodontais. O diagnóstico de diabetes mellitus foi estabelecido através da glicemia de jejum e de duas horas após sobrecarga com 75 g de glicose. Para análise estatística descritiva utilizou-se o programa SPSS v. 11. 5. Quanto às condições periodontais, observou-se que 57,8% dos indivíduos apresentaram sangramento à sondagem, 71,8% presença de cálculo, 3,63% bolsas superficiais e 0,28% bolsas profundas. Perdas de inserção periodontal maiores que 6 mm foram observadas em 3,0% dos indivíduos. Não foi observada associação estatisticamente significante entre diabetes e condições periodontais, embora indivíduos com diabetes tenham maior susceptibilidade a desenvolverem bolsas profundas. Conclui-se que a abordagem epidemiológica da condição periodontal e sua associação com doenças sistêmicas, como o diabetes mellitus, pode oferecer importante contribuição para prevenir suas complicações

  7. Celulitis orbitaria bilateral con endoftalmitis en una paciente con reciente diagnóstico de diabetes mellitus tipo 2

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    Lesley Farrell González

    2014-07-01

    Full Text Available Se presentó una mujer de 74 años al servicio de urgencias del HRAEBI, ISSSTE, el día 2 de septiembre de 2010 con datos de desequilibrio hidroelectrolítico, hipotensión y conjuntivitis bilateral. Sus signos vitales durante su estancia en urgencias fueron: tensión arterial, 80/40 mmHg; temperatura, 38.5 °C; frecuencia respiratoria, 22 rpm; frecuencia cardíaca 89 lpm Se interconsulta al servicio de Oftalmología quienes diagnosticaron celulitis orbitaria bilateral, con no percepción de luz en ambos ojos e igualmente ausencia de reflejos pupilares. Se inició tratamiento con antibióticos intravenosos y se solicitó tomografía computarizada de órbitas y cerebro. Se internó para estabilizar su estado general; durante su estancia se diagnosticó diabetes mellitus y estado inmunosupresivo por datos de candidiasis oral y otros síntomas. La tomografía mostró celulitis orbitaria bilateral con formación de abscesos orbitarios, sin datos de proceso infeccioso a nivel bucal o de senos paranasales. La evolución de la celulitis fue tórpida a pesar de la terapia antibiótica cuádruple (cefotaxima, vancomicina, metronidazol y clindamicina; posteriormente imipenem, clindamicina y vancomicina con desarrollo de endoftalmitis bilateral por lo cual fue necesario eviscerar ambos ojos. Se tomó cultivo directo del vítreo y 3 días después se encontró como germen causal Klebsiella pneumoniae.

  8. Diabetes mellitus tipo 2: qual o papel da insulina na expressão de NF-kappaB, PPARγ e CD36?

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    Cristina de Oliveira SILVA

    2014-12-01

    Full Text Available No diabetes mellitus tipo 2 (DM2 e na síndrome de resistência à insulina, as complicações cardiovasculares resultam de um conjunto de processos aterogênicos envolvendo hiperglicemia crônica, excessiva glicação de proteínas (AGEs, ativação do fator nuclear kappa B (NKκB associada com o aumento da expressão de citocinas inflamatórias e estresse oxidativo, observando-se ainda alteração de LDL e expressão do receptor de scavenger CD36. A contribuição da hiperinsulinemia nesta sequência não é completamente elucidada. Nesta revisão, relata-se como a insulina pode modular a expressão proteica de NFκB, PPAR gama (PPARγ e CD36 em células da musculatura lisa vascular (CMLV da aorta de ratos estimuladas pelos AGE.

  9. PREVALENCE OF DIABETIC RETINOPATHY IN PATIENTS WITH NEWLY DIAGNOSED TYPE II DIABETES MELLITUS

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    A. Bostak

    2006-11-01

    Full Text Available Diabetic retinopathy is a common complication of type II diabetes mellitus and carries with it the threat of blindness. Accurate information regarding the incidence of diabetic retinopathy and associated risk factors is important in the prevention of its development and of the visual impairment caused by this complication. This study was designed to determine the prevalence of diabetic retinopathy in newly diagnosed patients with type II diabetes mellitus. We have also evaluated the association of diabetic retinopathy with clinical and biochemical variables. In a cross-sectional study, 152 consecutive patients with newly diagnosed type II diabetes mellitus were referred from two outpatient clinics in Tehran for ophthalmologic exam to detect retinopathy. Indirect ophthalmoscopy was performed and data regarding risk factors were extracted from routine medical records. Chi square and Mann Whitney U tests were used to analyze the data. The overall prevalence of diabetic retinopathy was 13.8 %( 21 cases: three cases with microaneurysm only, 10 with mild, 5 with moderate and 2 with severe non proliferative diabetic retinopathy. Only one patient had advanced proliferative retinopathy. The prevalence of diabetic retinopathy was positively associated with age, duration of disease, fasting plasma glucose, HbA1c, and systolic blood pressure. Diabetic retinopathy is common in newly diagnosed type II diabetes mellitus patients. Ophthalmologic consultation is essential at the time of diagnosis for all patients.

  10. Priapism in type II Diabetes Mellitus: A case report | Muthuuri | East ...

    African Journals Online (AJOL)

    Priapism in type II diabetes mellitus is an uncommon event. A case of this condition in an adult male is presented. More common precipitating factors such as use of medications like sildenafil or use of an intracarvenosal vasodilator was absent, although diagnostic investigations postulated the cause as thrombotic factors in ...

  11. ESTILO DE VIDA Y ADHERENCIA AL TRATAMIENTO DE LA POBLACIÓN CANARIA CON DIABETES MELLITUS TIPO 2

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    Antonio Cabrera de León

    2009-01-01

    Full Text Available Fundamento: la población canaria sufre la mayor mortalidad por diabetes tipo 2 (DM2 en España. El objetivo de este estudio es conocer el estilo de vida de las personas diabéticas del archipiélago y su adherencia al tratamiento, así como la DM2 desconocida. Métodos: estudio transversal de 6.729 personas de la población general participantes en la cohorte "CDC de Canarias" (edad 18-75 años. Se obtuvieron sus antecedentes médicos, dieta, actividad física, medicamentos consumidos, tabaco, etc. Resultados: la prevalencia de DM2 fue 12% en varones y 10% en mujeres (p=0,005. El 22%de varones y 9% de mujeres desconocían su enfermedad (p<0,001. Sumando DM2 desconocida, DM2 no tratada e incumplimiento terapéutico, el 48% de los hombres y 28% en mujeres no seguían tratamiento correcto. Los varones diabéticos eran más obesos que los no diabéticos (45 versus 25%; p<0,001 pero no presentaban diferencias en tabaquismo (28%; IC95%=23-33 o sedentarismo (62%; IC95%=56-68. Las mujeres diabéticas también eran más obesas (54 versus 27%; p<0,001 y, aunque fumaban menos (11 versus 22%; p<0,001, eran igual de sedentarias (75%; IC95%=70-79. La ingesta calórica era menor en quienes sufrían DM2 (p<0,001, pero el 93% (IC95%=91-95 superaba el consumo recomendado de grasas saturadas y el 69% (IC95%=65-72 padecía síndrome metabólico. Conclusiones: la población diabética en Canarias es sedentaria y obesa, muestra un consumo alto de grasas saturadas y gran prevalencia de síndrome metabólico. El porcentaje que sigue tratamiento regular es muy bajo, sobretodo en varones, que además mantienen el tabaquismo.

  12. Diabetes tipo 2 en niños y adolescentes: aspectos clínico-epidemiológicos, patogénicos y terapéuticos Type 2 diabetes mellitus in children and adolescents: clinicoepidemiological, pathogenic and therapeutic aspects

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    Manuel Emiliano Licea Puig

    2008-04-01

    Full Text Available OBJETIVO: debido al incremento sostenido en la incidencia de la diabetes mellitus tipo 2 en personas OBJECTIVE: due to the sustained increase in the incidence of type 2 diabetes mellitus in persons under 20, the clinicoepidemiological, pathogenic and therapeutic aspects of type 2 diabetes mellitus in children and adolescents were reviewed. DEVELOPMENT: in children, it is estimated that type 2 diabetes mellitus accounts for 2-3 % of all cases. However, in the last years, there has been a ten-fold increase. Its prevalence is higher among Afro-Americans, Hispanics and native Americans, in puberty and in those with history of type 2 maternal diabetes mellitus. Type 2 diabetes mellitus is the result of the interaction of genetic and environmental factors (obesity, physical inactivity, poor nutritional habits, among others. There is a wide range of clinical manifestations: severe hyperglycaemia with ketonuria and ketosis to a mild hyperglycaemia. 50 % may be asymptomatic. Obesity, Acantosis nigricans, family history of type 2 diabetes mellitus, puberty, and type 2 maternal diabetes mellitus are risk factors. It prevails in females, autoimmunity is rare and the dependence on insulin may be episodic. Those with the highest hyperglycaemia have lower levels of insulinemia and peptide C. When hyperglycaemia is mild, diet, physical exercise and, in some cases, the administration of oral drugs, such as metformin, may be useful. CONCLUSIONS: type 2 diabetes mellitus in children and adolescents is a reality. Evolutively, most of them do not need insulin therapy. They may have retinopathy, microalbuminuria, dyslipidemia and arterial hypertension on diagnosis. Risk populations should be actively screened.

  13. Avances en terapia insulínica en la diabetes mellitus tipo 1: Aciertos y desaciertos Advances in insulin-therapy in type 1 diabetes mellitus: Success and failures

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    Tania Mayvel Espinosa Reyes

    2007-04-01

    Full Text Available La historia del desarrollo del tratamiento farmacológico de la diabetes tuvo un capítulo esencial en el descubrimiento de la insulina y su introducción como terapia de la diabetes tipo 1. El conocimiento de sus complicaciones trajo consigo la necesidad de una terapia más sofisticada. Desde entonces, las preparaciones de insulina y las estrategias terapéuticas han ido desarrollándose inicialmente a expensas del origen de la insulina, y posteriormente con la incorporación de sustancias que modificaban su absorción. Ya en la década de los 90 surgieron entonces los análogos de la insulina, con una especial capacidad de cambio en su farmacocinética. Más adelante se introdujeron nuevas formas de liberación, que son, las bombas de infusión continua, los aerosoles y todo esto apoyado por nuevos sistemas de monitorización de la glucosa. En la última década el trasplante de islotes y la terapia génica con la obtención de células ß a partir de células madres pluripotenciales, aumentan las expectativas en este campo. Todos estos elementos confirman el interminable camino en la búsqueda de terapéuticas eficaces en el tratamiento de la diabetes mellitus tipo 1. Con este trabajo nos proponemos exponer los principales avances en materia de terapia insulínica y reflexionar sobre aciertos y desaciertos en su introducción.History of development of pharmacological treatment of diabetes had an essential chapter in descovery of insulin and its introduction as therapy of Type 1 diabetes. Knowledge of its complications, lead to the need of a more sophisticated therapy. Since then, insulin preparations and therapeutical strategies has been initially developing at the expense of insulin origin, and then with incorporation of substances modifying its absorption. As long as in 1990, emerged insulin analogues with an special change ability in its pharmacokinetics. Then, new ways of release were introduced, e.g. continuous infusion pumps, aerosols

  14. Prevenzione e terapia precoce del diabete mellito di tipo II: aspetti farmacoeconomici

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    Lorenzo Pradelli

    2005-09-01

    Full Text Available Type II (non-insulin-dependent diabetes is one of the most widespread chronic patologies in the developed countries and its prevalence in Italy is about 2-3% of the population. Type II diabetes is also associated with several other metabolic abnormalities such as central obesity, hypertension, and dyslipidemia, which contributes to the very high rate of cardiovascular morbidity and mortality. Therefore Type II diabetes involves a significant financial burden on the health care system. The purpose of this paper is to explain the composition of the healthcare costs of managing people with Type II diabetes and the economic repercussions due to the adoption of an aggressive strategy against the pathology. To carry out this evaluation we considered the CODE-2 (The Cost of Diabetes in Europe - Type II Study results, the American Diabetes Association Position Statement, the Diabetes Prevention Program and the UK Prospective Diabetes Study. Evidence exists to show that introducing prevention program or an early therapy can avert or delay significantly the onset of cardiovascular morbidity in Type II diabetes patients. According to the pharmacoeconomical criteria, this very desiderable clinical goal is associated to a little increase of the health expenditures, and sometimes also to a costs saving.

  15. Caracterización del control metabólico en niños y adolescentes con diabetes mellitus tipo 1 Characterization of the metabolic control in children and adolescents with type I diabetes mellitus

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    Pedro González Fernández

    2012-08-01

    Full Text Available Introducción: el control metabólico es el propósito principal en el tratamiento de la diabetes mellitus. Objetivo: caracterizar el control metabólico en un grupo de niños y adolescentes con diabetes mellitus tipo 1. Métodos: se realizó un estudio prospectivo en 84 pacientes con diabetes mellitus tipo 1 atendidos en el servicio de Endocrinología del Hospital Pediátrico Universitario "William Soler" entre febrero de 2010 y agosto de 2011. Se determinó hemoglobina glucosilada (HbA1c con un intervalo de entre 90 y 120 días. Para la determinación de la HbA1c se utilizó el método cuantitativo turbidimétrico con el reactivo fabricado por Futura System. Los resultados trimestrales de HbA1c se relacionaron con la edad, el sexo, el tiempo de evolución de la diabetes mellitus, el peso corporal en kilogramos y la dosis total diaria de insulina. Resultados: la edad promedio de los pacientes del sexo masculino fue 11,6 años (DS 4,6 y la de los del sexo femenino, 12,4 años (DS 4,5. La edad media al inicio del estudio fue 12,23 años (DS 4,42 y la edad media al diagnóstico de la diabetes, 8,27 años (DS 4,28. El tiempo promedio de evolución de la diabetes fue 3,79 años (DS 3,17 y la dosis media diaria de insulina por kilogramo de peso corporal fue de 0,91 unidades (DS 0,26. Los valores de la HbA1c se mantuvieron por encima de 10 %, salvo las dos últimas determinaciones, que mostraron valores significativamente menores que los meses anteriores, y fueron independientes de las variables sexo, tiempo de evolución, edad de diagnóstico y dosis promedio diaria de insulina por kilogramo de peso corporal. Conclusiones: una relación clínica adecuada y la mejoría en el cumplimiento del tratamiento fueron elementos decisivos en la mejoría del control metabólico en nuestros pacientes.Introduction: the metabolic control is the main objective of the diabetes mellitus treatment. Objective: to characterize the metabolic control in a group of

  16. Lepra: Sepsis en un paciente con reacción tipo II. Reporte de un caso

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    Edinson Enrique Escalante Gómez

    2012-08-01

    Full Text Available La lepra es una patología infecciosa de carácter crónico, caracterizada por un amplio compromiso cutáneo, asociado a neuropatía, con bajas tasas de mortalidad, pero con un alto índice de discapacidad. Es causada por la infección por el bacilo, Mycobacterium leprae. A pesar que se conoce desde la antigüedad se considera un problema persistente de salud pública en áreas subtropicales donde es endémica. Su mecanismo de transmisión, es por medio de gotitas respirato-rias. Su espectro clínico es muy variado, depende de la forma en que el sistema inmunitario del huésped reacciona frente al agente infeccioso, por lo que se reconocen los polos determinados como tuberculoide y lepromatoso, una forma indeterminada y borderline. Por otro lado se considera que la reacciones lepróticas (tipo 1, tipo 2 y fenómeno de lucio son complicaciones de la hiperreactividad inmunológica que aparece cuando se afecta el equilibrio inmunológico en el huésped. En 1982 la Organización Mundial de la Salud estableció la terapia multidrogas como herramienta eficaz para el control de esta entidad. Actualmente el régimen farmacológico se establece teniendo en cuenta la clasificación que distingue al enfermo en paucibacilar y multibacilar. Presentamos un paciente masculino de 64 años, con antecedente de lepra lepromatosa multibacilar desde hace 3 años, con tratamiento irregular, suspendido 6 meses antes de clínica de ingreso consistente sepsis de origen urinario, con posterior septicemia asociada al catéter, a quien se le realiza tratamiento antibiótico de amplio espectro, con evolución satisfactoria del estado hemodinámico y manejo de la lepra ambulatorio.

  17. Papel de la testosterona y el cortisol en el síndrome metabólico y la diabetes mellitus tipo 2 Role of testosterone and cortisol in metabolic syndrome and type 2 diabetes mellitus

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    Aimée M. Álvarez Álvarez

    2010-04-01

    Full Text Available INTRODUCCIÓN: el síndrome metabólico y la diabetes mellitus tipo 2 son trastornos metabólicos que han sido ampliamente abordados en la literatura científica por su alta incidencia, así como la alta morbilidad y mortalidad que a ellos se asocia. En los últimos años se han explorado nuevos elementos de posible impacto en su fisiopatogenia, dentro de los que se destacan los esteroides sexuales y los glucocorticoides. En este trabajo se revisaron y comentaron los conocimientos más actuales sobre el papel de la testosterona y el cortisol en la fisiopatogenia del síndrome metabólico y de la diabetes mellitus tipo 2 en los hombres. DESARROLLO: la testosterona desempeña un papel importante en la modulación de la sensibilidad a la insulina y en la homeostasis de la glucosa, de manera que en los hombres, los niveles bajos de testosterona resultan un elemento predictor de la diabetes mellitus tipo 2 y del síndrome metabólico. Se ha establecido la existencia de una relación bidireccional y reversible entre la deficiencia de andrógenos y la adiposidad, así como entre la deficiencia de andrógenos y la resistencia a la insulina. Se sugiere que los niveles bajos de testosterona podrían predisponer a la obesidad abdominal, que provoca una alteración del metabolismo de los ácidos grasos, lo cual a la vez promovería la resistencia a la insulina. La secreción de cortisol y la de testosterona están interrelacionadas y tienen efectos inversos sobre la resistencia a la insulina. En la obesidad abdominal el eje hipotalámico-hipofisario-adrenal se hipersensibiliza lo cual provoca aumento frecuente de la secreción de cortisol y disminución de la secreción de esteroides sexuales. Por otro lado, un aumento desproporcionado de la respuesta fisiológica al estrés, induce un incremento de la secreción de cortisol que podría a su vez causar la aparición de la resistencia a la insulina y del síndrome metabólico. Uno de los mecanismos patog

  18. AS IMPLICAÇÕES DO POLIMORFISMO GENÉTICO DO GENE GST NA PATOGÊNESE DO DIABETES MELLITUS TIPO 2

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    Angela Adamski da Silva Reis

    2011-01-01

    Full Text Available Type 2 Diabetes mellitus (T2DM is a disease characterized by chronic hyperglycemia associated with metabolic complications, clinical and social, resulting from the aging population, increasing urbanization and the adoption of unhealthy lifestyles such as sedentary lifestyles, poor diet and especially obesity. Complex diseases like diabetes, are determined by three main factors: the lifestyle, environmental exposure and genetic susceptibility. Thegenetic contribution is important evidence in the development of T2DM. Several polymorphisms of genes responsible for encoding enzymes involved in the biotransformation of xenobiotics are related to the development of atherosclerosis, cancer and type 2 diabetes. In the pathogenesis of T2DM, it is observed that oxidative stress contributes to decreased production and reduced ability of insulin to stimulate glucose uptake. In this sense, the polymorphism ofenzymes of xenobiotic metabolism phase II has been extensively studied in a wide variety of diseases, especially in determining genetic susceptibility to cancer and response to chemotherapy.

  19. Prevalencia de neuropatía autonómica cardiovascular en pacientes con diabetes mellitus tipo 2 de un hospital general.

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    Ray Ticse Aguirre

    2007-07-01

    Full Text Available Objetivo: Determinar la prevalencia de la neuropatía autonómica cardiovascular (NACV en pacientes con diabetes tipo 2, que acuden de manera regular al consultorio del servicio de Endocrinología del Hospital Nacional Cayetano Heredia (HNCH y los factores que se asocian a su presentación. Material y Métodos: Ingresaron 81 pacientes que cumplieron con los criterios de inclusión y exclusión. Se aplicaron cuatro pruebas para el diagnóstico de NACV, según el consenso de San Antonio sobre Neuropatía Diabética: Test de Valsalva, razón 30/15, hipotensión ortostática y variación de la frecuencia cardiaca. Además se tomaron datos demográficos, metabólicos, patológicos y de complicaciones por la diabetes. Se aplicó el test MDNS (Michigan Diabetic Neuropatic Score y electromiografía para el diagnóstico de neuropatía periférica. Se dividió en dos grupos según la presencia o no de NACV y se buscó diferencias. Resultados: El grupo de pacientes con NACV presentó mayor tiempo de enfermedad (10,36 ± 6,88 vs 6,32 ± 6,75; p=0,008, mayores niveles de glicemia en ayunas (160,55 ± 54,78 vs 120,63 ± 43,68; p=0,001 y de hemoglobina glicosilada (10,47 ± 2,06 vs 9,30 ± 2,14; p=0,013. No se halló diferencias significativas en las demás variables. Conclusiones: La frecuencia de de NACV en pacientes con diabetes mellitus tipo 2 del HNCH es de 41,47%. Se asocia a niveles altos de glucosa en ayunas, hemoglobina glicosilada.y mayor tiempo de enfermedad. (Rev Med Hered 2007;18:129-135.

  20. Physical activity in type II Diabetes Mellitus, an effective therapeutic element: review of the clinical impact

    Directory of Open Access Journals (Sweden)

    Pedro Iván Arias-Vázquez

    2015-07-01

    Full Text Available A review was conducted in databases (PubMed, PEDro of type studies clinical trial, cohort study, systematic reviews, meta-analysis and clinical practice guidelines based on evidence they have studied the benefits of physical activity in the prevention , treatment and decreased risk of complications and death in patients with Type II Diabetes Mellitus. Realization regular physical activity is associated with a decreased risk of developing Diabetes Mellitus; likewise was associated with decrease in glycated hemoglobin percentage A1C values. Diabetic patients undergoing high levels of physical activity had decreased risk of complications and death from cardiovascular disease and all causes. At present the scientific evidence on the impact of physical activity in the prevention and treatment of Diabetes Mellitus is solid, so it must be emphasized promoting physical activity as a fundamental part of the therapeutic regimens for this disease.

  1. [Increased risk of type II diabetes mellitus and cardiovascular disease after gestational diabetes mellitus: a systematic review].

    Science.gov (United States)

    Hopmans, Tara-Eileen J P; van Houten, Chantal B; Kasius, Annemieke; Kouznetsova, Ouliana I; Nguyen, Ly A; Rooijmans, Sanne V; Voormolen, Daphne N; van Vliet, Elvira O G; Franx, Arie; Koster, M P H Wendy

    2015-01-01

    To determine the long-term risk of developing type II diabetes (T2D) and cardiovascular disease (CVD) for women with a history of gestational diabetes mellitus. Systematic review and meta-analysis. Two search strategies were used in PubMed and Embase to determine the long-term risks of developing T2D and CVD after a pregnancy complicated by gestational diabetes mellitus. After critical appraisal of the papers found, 11 papers were included, involving a total of 328,423 patients. Absolute and relative risks (RRs) were calculated. Eight studies (n=276,829) reported on the long-term risk of T2D and 4 (n=141,048) on the long-term risk of CVD. Follow-up ranged from 3.5 to 11.5 years for T2D and from 1.2 to 74.0 years for CVD. Women with gestational diabetes had a risk of T2D varying between 9.5% and 37.0% and a risk of CVD of between 0.28% and 15.5%. Women with gestational diabetes were at increased risk of T2D (weighted RR: 13.2; 95% CI: 8.5-20.7) and CVD (weighted RR: 2.0; 95% CI: 1.1-3.7) compared to women without gestational diabetes. Women with prior gestational diabetes mellitus have a significantly increased risk of developing T2D and CVD. It is very important that gestational diabetes is recognised as a cardiovascular risk factor in daily practice. It would be desirable to screen this group of women for the presence of hyperglycaemia and other cardiovascular risk factors. Further research is required to be able to specify the long-term risk of T2D and CVD and to demonstrate whether such screening is cost-effective.

  2. Potencial efeito benéfico da suplementação de colecalciferol na prevenção do Diabetes Mellitus tipo 1

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    Rafaella Gonçalves Ferreira de Oliveira

    2015-06-01

    Full Text Available Introdução: O diabetes mellitus tipo 1 (DM1 é uma condição de etiologia complexa, imunomediada na qual fatores ambientais e determinantes genéticos interagem resultando na destruição específica de células beta. Antes de essa destruição chegar a níveis críticos, quando se desenvolve a doença manifesta e sua sintomatologia clássica, existe um período pré-clínico, de duração variável, onde o paciente permanece assintomático. Isso vem instigando cada vez mais as pesquisas, na tentativa de identificar possíveis marcadores da doença nessa fase precoce. Objetivo: Descrever a evolução clínico-laboratorial de uma família com três indivíduos relacionados em 1º grau, que tinham títulos de anticorpos elevados - pai, filha (17 anos e filho (12 anos, este último (caso-índice apresentava também glicemia alterada - com a suplementação de vitamina D, objetivando um possível efeito benéfico sobre a potencial evolução para DM1; além de descrever os principais aspectos clínicos e laboratoriais relacionados ao Pré Diabetes Mellitus Tipo 1 , baseando-se nos estudos descritos na literatura mundial. Metodologia: Revisão de prontuário, acompanhamento clínico laboratorial dos pacientes e pesquisa bibliográfica nas bases de dados MEDLINE, LILACS, SciELO e MD Consult. Resultado: Todos iniciaram 4000UI/dia de colecalciferol, mantendo cuidados (alimentação saudável e atividade física regular, sendo observada euglicemia e redução dos títulos de anti-GAD após um ano de seguimento e 8 meses de suplementação. Dentre os irmãos que apresentavam positividade para autoanticorpos antiilhotas, aquele que apresentava deficiência de vitamina D foi o primeiro a desenvolver alterações glicêmicas, mesmo tendo níveis de autoanticorpos menores que a irmã sem alterações glicêmicas.  Conclusão: estes dados sugerem possível benefício da suplementação da vitamina D na evolução do DM1 em fase precoce. Estudos

  3. Asociación entre diabetes mellitus tipo 2 y actividad física en personas con antecedentes familiares de diabetes

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    Fanny Petermann

    2018-05-01

    Full Text Available Resumen: Objetivo: Investigar si la asociación entre diabetes mellitus tipo 2 (DMT2 y antecedentes familiares de DMT2 resulta modificada por los niveles de actividad física en población chilena. Método: Se incluyeron en el estudio 5129 participantes de la Encuesta Nacional de Salud de Chile. El tiempo destinado a realizar actividad física se determinó por el cuestionario GPAQ v2, y los antecedentes familiares mediante el autorreporte de cada participante. La asociación entre DMT2, antecedentes familiares de DMT2 y actividad física fue investigada por sexo mediante regresión logística. Resultados: El riesgo de desarrollar DMT2 en personas con antecedentes familiares de esta enfermedad es elevado, independientemente de su nivel de actividad física y de su adiposidad. Tanto las mujeres como los hombres físicamente inactivos y con antecedentes familiares de DMT2 presentan mayor probabilidad de desarrollar DMT2 (odds ratio [OR] mujeres: 5,49; intervalo de confianza del 95% [IC95%]: 3,85-7,84; p <0,0001; y OR hombres: 8,16; IC95%: 4,96-13,4; p <0,0001, comparados con sus pares sin antecedentes familiares y activos físicamente. Conclusión: Dado el alto riesgo de desarrollar DMT2 que presentan los individuos con antecedentes familiares de esta enfermedad, y el efecto de la actividad física en la disminución de dicho riesgo, es esencial incrementar los niveles de actividad física en la población que presenta mayor susceptibilidad a DMT2. Abstract: Objective: To investigate whether the association between type 2 diabetes (T2D and family history of diabetes is modified by the levels of physical activity in the Chilean population. Method: In this study were included 5129 participants from the cross-sectional 2009-2010 National Health Survey. Physical activity level was assessed using the Global Physical Activity Questionnaire and family history of T2D, through self-reporting. The association between diabetes, family history of diabetes and

  4. Impacto de un servicio de seguimiento farmacoterapéutico implementado a pacientes con diabetes mellitus tipo 2 Impact of a pharmaceutical follow-up service implemented in type 2 diabetes mellitus patients

    Directory of Open Access Journals (Sweden)

    Yaily Lazo Roblejo

    2011-06-01

    Full Text Available Se evaluó el impacto de un servicio de seguimiento farmacoterapéutico implementado a 30 pacientes con diabetes mellitus tipo 2, dispensarizados en la Farmacia Principal Municipal Santiago de Cuba, según la metodología Dáder, en el período comprendido desde enero del 2009 hasta enero de 2010. El índice de impacto de la estabilidad clínica de los pacientes resultó moderado, mientras que en las intervenciones farmacéuticas aceptadas y el nivel de satisfacción de los pacientes, los índices de impacto obtenidos fueron elevados, por lo que el impacto global del servicio de seguimiento farmacoterapéutico implementado para la atención de estos fue considerado alto.The impact of a pharmacotherapy follow-up service was assessed in 30 patients dispensarized in municipal main drugstore of Santiago de Cuba according to Dáder's methodology from January, 2009 to January, 2010. The level of the clinical stability impact of patients was qualified as moderate, whereas in the accepted pharmaceutical interventions and at level of patient's satisfaction, the rates of impact achieved were high thus; the global above mentioned service repercussion was also qualified as high.

  5. Hallazgos electroencefalográficos e hipoglucemia severa en niños con diabetes mellitus tipo 1 Electroencephalographic findings and severe hypoglycemia in children with type 1 diabetes mellitus

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    Pedro González Fernández

    2003-08-01

    Full Text Available Los episodios de hipoglucemia severa (HS constituyen un riesgo por ocasionar alteraciones de la función cerebral y del trazado electroencefalográfico (EEG en pacientes con diabetes. El presente estudio tiene como objetivo determinar la frecuencia de alteraciones del EEG después del diagnóstico de diabetes en un grupo de niños y su posible relación con HS, edad, control metabólico y tiempo de evolución de la diabetes. Se estudiaron retrospectivamente 40 niños con edades comprendidas entre 1 y 17 años (media de 12 años con diagnóstico de diabetes mellitus tipo 1 atendidos en el servicio de endocrinología del Hospital Pediátrico Docente "William Soler", en el período comprendido entre abril de 1990 y abril de 1998. Se tomaron los resultados de la hemoglobina glucosilada, así como los episodios referidos de HS. Se realizó EEG al diagnóstico de la diabetes y anualmente. Se clasificaron los EEG anormales de acuerdo con el tipo de trazado. Se encontraron EEG anormales en aproximadamente la mitad de los pacientes (45 % con predominio del trazado con descargas focales, los que fueron significativamente mayor en los pacientes con 2 ó más HS y con una edad menor al diagnóstico de la diabetes. No se encontró relación entre el EEG anormal y el control metabólico ni con el tiempo de evolución de la diabetes. La frecuencia hallada en este estudio enfatiza la importancia de realizar EEG al diagnóstico de DM y posteriormente, sobre todo en aquellos pacientes con HS y edad menor de 6 años.Episodes of severe hypoglycemia (SH constitute a risk because it causes brain function and electroencephalographic recording (EEG disturbances in patients with diabetes. This study was aimed at determining the frequency of EEG alterations after the diagnosis of diabetes in a group of children and their possible relation with SH, age, metabolic control and progression of diabetes. Forty children aged 1 to 17 years (average 12 years diagnosed with type 1

  6. Hypertension In Type II Diabetes Mellitus In Jos University Teaching ...

    African Journals Online (AJOL)

    Methods: A cross-sectional study of hypertension in type II diabetic patients in Jos University Teaching Hospital, Jos, Nigeria Results: Forty-two of the patients were hypertensive with only 28 (32.9%) previously diagnosed and were on treatment. Age of patient, duration of diabetes and diabetic retinopathy were significantly ...

  7. Left Ventricular Geometry In Nigerians With Type II Diabetes Mellitus ...

    African Journals Online (AJOL)

    Background: Left ventricular hypertrophy is independently associated with increased incidence of cardiovascular disease, cardiovascular and all cause mortality. In a relatively healthy hypertensive adult population, type II diabetes is associated with higher left ventricular mass, concentric left ventricular geometry and lower ...

  8. Distribuição de transtornos alimentares em indivíduos com diabetes melito do tipo 1 e do tipo 2: descrição de dois casos Distribution of eating disorders in subjects with type 1 and type 2 diabetes mellitus: a description of two cases

    Directory of Open Access Journals (Sweden)

    Marcelo Papelbaum

    2007-04-01

    Full Text Available A presença de alterações do comportamento alimentar parece estar aumentada no diabetes melito (DM. Entretanto, a distribuição das diversas categorias de transtornos alimentares tende a se distinguir de acordo com a fisiopatologia do diabetes. O objetivo dessa apresentação é discutir dois casos distintos de ocorrência de transtornos alimentares no DM do tipo 1 (DM1 e no DM do tipo 2 (DM2. A paciente A é do sexo feminino, tem 19 anos e apresenta DM1 desde os 13 anos. Evidenciava sintomas depressivos proeminentes e, há 2 anos, passou a apresentar episódios de compulsão alimentar seguidos de vômitos auto-induzidos e omissão das doses de insulina com o objetivo de evitar ganho de peso. Em função desse comportamento, apresentou diversas internações associadas a uma piora do controle glicêmico. Após o uso de fluoxetina, houve remissão da psicopatologia alimentar e melhora do controle do DM. A paciente B possui 42 anos e é portadora do DM2 há 6 anos. Apresenta obesidade grau II e vinha exibindo, antes mesmo do diagnóstico do DM2, episódios de compulsão alimentar na ausência de comportamentos compensatórios, que prejudicavam o controle metabólico do diabetes. Foi iniciada fluoxetina até a dose de 60 mg/dia, com remissão do descontrole alimentar, perda ponderal e redução da hemoglobina glicosilada. A incidência de transtornos alimentares no DM1 estaria associada com um aumento da preocupação com a forma corporal e a possibilidade da omissão do uso da insulina como comportamento compensatório. No DM2, a obesidade seria um dos fatores associados ao desenvolvimento da psicopatologia alimentar.The presence of changes in eating behavior seems to be increased in diabetes mellitus (DM. However, the distribution of varied categories of eating disorders tends to be distinguished according to the physiopathology of diabetes. The objective of this report is to discuss two distinct cases of eating disorders in type 1 (T1DM and

  9. Relação entre retinopatia diabética e dermopatia diabética em pacientes portadores de diabetes mellitus tipo 2 Relation between diabetic retinopathy and diabetic dermopathy in type 2 diabetes mellitus patients

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    Hugo Roberto Kurtz Lisboa

    2008-12-01

    Full Text Available OBJETIVOS: Dermopatia diabética é o marcador cutâneo mais comum de diabetes mellitus. Embora, a dermopatia e a retinopatia diabéticas sejam consideradas manifestações de microangiopatia diabética, poucos estudos foram publicados a respeito de uma possível associação. Este estudo pretendeu investigar a associação de retinopatia e dermopatia diabéticas e determinar a prevalência e os fatores de risco associados com retinopatia diabética em pacientes diabéticos do tipo 2 do Ambulatório de Diabetes da Faculdade de Medicina da Universidade de Passo Fundo no Hospital de Ensino São Vicente de Paulo. MÉTODOS: Estudo transversal de 90 pacientes diabéticos tipo 2, atendidos sucessivamente em um Ambulatório de Diabetes nos quais foi realizado exame físico dermatológico e oftalmológico. RESULTADOS: A prevalência de dermopatia diabética foi de 16,6% (n = 15 e a de retinopatia diabética foi de 34,4% (n = 31. Destes, 67,8% (n = 21 consistiam em retinopatia não-proliferativa e 32,2% (n = 10 em retinopatia proliferativa. Observou-se que a duração da doença maior do que 10 anos (p = 0,001 e idade maior que 50 anos (p = 0,014 estavam associadas à retinopatia. Não se encontrou associação entre hemoglobina glicada (p = 0,5 e glicemia de jejum (p = 0,8 com retinopatia diabética. A freqüência de retinopatia diabética em pacientes com dermopatia diabética não foi maior do que nos pacientes sem dermopatia (7,7%, 7 casos, p = 0,586. Não houve associação, estatisticamente significativa, entre retinopatia e dermopatia diabéticas. CONCLUSÃO: Não se encontrou associação entre dermopatia e retinopatia diabéticas entre estes indivíduos com diabetes mellitus do tipo 2. A presença de retinopatia diabética estava associada à duração da doença e à idade avançada dos pacientes.PURPOSE: Diabetic dermopathy is the most frequent cutaneous marker of diabetes mellitus. Although diabetic dermopathy and diabetic retinopathy are

  10. Frequency of hypomagnesemia in patients with uncontrolled type II diabetes mellitus

    International Nuclear Information System (INIS)

    Siddiqui, M.U.; Ali, I.; Asghar, S.P.; Ahmed, M.R.

    2016-01-01

    Objective: The objective of this study was to determine the frequency of Hypomagnesemia in patients with uncontrolled type II diabetes mellitus. Study Design: Cross-sectional study. Place and Duration of Study: Department of Medicine, PNS Shifa Naval Hospital Karachi, from Jul 2012 to Dec 2012 over a period of six months. Material and Methods: In this study, three hundred and twenty three patients of uncontrolled diabetes mellitus type-II on oral hypoglycemic agents for more than five years, presenting to medical OPD, were recruited. All patients fulfilled inclusion and exclusion criteria. Blood samples of all patients for serum HbA1c and serum magnesium levels were analyzed at the time of enrollment. Statistical analysis was done on SPSS 20. Results: Out of 323 patients, 243 (75.23 percent) were males and 80 (24.76 percent) were females with the age ranging from 40 - 65 years (mean age and SD 54.76 +- 6.43). Hypomagnesemia was found in 117 patients, without any significant difference in men and women (38.45 percent and 35.39 percent respectively). The mean duration of diabetes was 12.5 years (ranging from 5 to 22 years). By frequency test in SPSS-20, the highest frequency of hypomagnesemia (49.42 percent) is seen in (8.6-9.0) HbA1c group while lowest frequency hypomagnesemia (15.38 percent) is seen in (>10.0) HbA1c level group mean standard deviation and p-value calculated by Pearson correlation statistic in SPSS-20 for quantitative variables (HbA1c, Magnesium level). Conclusion: Hypomagnesemia is frequent in poorly controlled type-II diabetes mellitus having increased level of HbA1c. So it may be prudent in clinical practice to periodically monitor plasma magnesium and HbA1c in type-II diabetes mellitus patients. (author)

  11. Creatine Kinase Activity in Patients with Diabetes Mellitus Type I and Type II

    Directory of Open Access Journals (Sweden)

    Adlija Jevrić-Čaušević

    2006-08-01

    Full Text Available Diabetes mellitus can be looked upon as an array of diseases, all of which exhibit common symptoms. While pathogenesis of IDDM (insulin dependant diabetes mellitus is well understood, the same is not true for diabetes mellitus type II. In the latter case, relative contribution of the two factors (insulin resistance or decreased insulin secretion varies individually, being highly increased in peripheral tissues and strictly dependant on insulin for glucose uptake. Moreover, in patients with diabetes mellitus type II, disbalance at the level of regulation of glucose metabolism as well as lipid metabolism has been noted in skeletal muscles. It is normal to assume that in this type of diabetes, these changes are reflected at the level of total activity of enzyme creatine kinase. This experimental work was performed on a group of 80 regular patients of Sarajevo General Hospital. Forty of those patients were classified as patients with diabetes type I and forty as patients with diabetes type II. Each group of patients was carefully chosen and constituted of equal number of males and females. The same was applied for adequate controls. Concentration of glucose was determined for each patient with GOD method, while activity of creatine kinase was determined with CK-NAC activated kit. Statistical analysis of the results was performed with SPSS software for Windows. Obtained results point out highly expressed differences in enzyme activity between two populations examined. Changes in enzyme activity are more expressed in patients with diabetes type II. Positive correlation between concentration of glucose and serum activity of the enzyme is seen in both categories of diabetic patients which is not the case for the patients in control group. At the same time, correlation between age and type of diabetes does exist . This is not followed at the level of enzyme activity or concentration of glucose.

  12. Role of autogenic relaxation in management of diabetic cardiovascular autonomic neuropathy in type II diabetes mellitus patients

    OpenAIRE

    Manish K. Verma; D. A. Biswas; Shambhavi Tripathi; N. S. Verma

    2016-01-01

    Background: Cardiac autonomic neuropathy (CAN) is a very common complication of Type II diabetes mellitus patients. Early detection and treatment of CAN is necessary for reduction of mortality and morbidity in type II diabetes patients. Methods: The study included 120 diagnosed cases of type 2 diabetes mellitus with autonomic neuropathy both male and female, with more than 5 years duration of disease. Age group of the study subjects was between 30 and ndash; 70 years. All the 120 diabet...

  13. Características clínicas y bioquímicas de la diabetes mellitus tipo 2 (DMt2 en el Instituto Nacional de Salud del Niño

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    Martha Calagua-Quispe

    2012-04-01

    Full Text Available Objetivo: Evaluar las características clínicas y bioquímicas al momento del diagnóstico de diabetes mellitus tipo 2 (DMt2, en pacientes pediátricos. Diseño: Estudio clínico retrospectivo. Institución: Servicio de Endocrinología, Instituto Nacional de Salud del Niño, Lima, Perú. Pacientes: Niños con diabetes mellitus tipo 2. Métodos: Se revisó las historias clínicas de 187 pacientes con diabetes mellitus y se identificó 17 (9,2% con diabetes mellitus tipo 2. Se preparó una ficha para la recolección de datos, en la cual se consignó características personales y familiares, síntomas y signos y datos bioquímicos. Principales medidas de resultados: Características clínicas y bioquímicas de los niños. Resultados: La edad promedio al momento del diagnóstico fue de 12,8 ± 3 años; 11 fueron de sexo masculino (64,7% y 6 de sexo femenino (35,3%. Todos nacieron a término, de los cuales 17,6% fueron macrosómicos. Se encontró que 82,4% tenía antecedente familiar de diabetes tipo 2. Los síntomas más frecuentes fueron: poliuria, polidipsia, polifagia y pérdida de peso; 35,3% presentó sobrepeso, 41,2% obesidad y 65% del conjunto, acantosis nigricans. Cinco pacientes desarrollaron cetoacidosis. Se encontró que 60% tenía alteración de alguno de los componentes del perfil lipídico, siendo la más frecuente la alteración de los LDL (46,5%. Los anticuerpos anti-insulina, anti-GAD y anti-ICA fueron negativos en 85,7%; 14,3% de los pacientes mostró alguno de ellos positivos. Conclusiones: La mayor parte de los niños con DMt2 estudiados presentó antecedentes familiares de diabetes tipo 2, 75% de ellos con signos y síntomas clásicos de esta patología, acompañados de presencia de sobrepeso u obesidad y dislipidemia.

  14. Frecuencia de mutaciones en el gen de la usherina (USH2A en 26 individuos colombianos con síndrome de Usher, tipo II

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    Greizy López

    2011-04-01

    Conclusiones. Se logró establecer que, al menos, 38 % de la población analizada con síndrome de Usher, tipo II, presenta alguna mutación en la isoforma corta del gen de la usherina. El diagnóstico molecular se logró establecer en el 23 %.

  15. Análise comparativa do risco de quedas entre pacientes com e sem diabetes mellitus tipo 2 Comparative analysis of risk for falls in patients with and without type 2 diabetes mellitus

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    Patricia Pereira de Oliveira

    2012-04-01

    Full Text Available OBJETIVO: Comparar a frequência e o risco de quedas baseado em teste de mobilidade funcional entre diabéticos e não diabéticos. MÉTODOS: Estudo transversal envolvendo pacientes com e sem diabetes mellitus tipo 2 (DM2 selecionados por amostra de conveniência. Foram incluídos homens e mulheres entre 50 e 65 anos, sendo divididos em: grupo 1 (G1 - com diagnóstico de DM2 200 mg/dL no momento da inclusão e prévia; e grupo 2 (G2 - sem diabetes, de mesma faixa etária, e glicemia de jejum OBJECTIVE: To compare frequency and risk of falls based on a functional mobility test in diabetic and non-diabetic individuals. METHODS: Cross-sectional study involving patients with and without type 2 diabetes mellitus (DM2 selected by convenience sampling. Men and women between the ages of 50 and 65 were included and divided as group 1 (G1 - with DM2 diagnosis for 200 mg/dL; and group 2 (G2 - no diabetes, same age group, and fasting blood glucose < 100 mg/dL. Both groups responded to a structured questionnaire about their health, fall risk, and underwent a physical exam and a mobility assessment test (Timed Up and Go - TUG. The results were analyzed by the software SPSS, with TUG being categorized in ranges of risk for fall. We considered that the risk was positive for all those who fit into medium- and high-risk range. RESULTS: Fifty patients with DM2 and 68 patients without DM2 were assessed. There were no statistical differences in the number of falls between the groups, however non-diabetic subjects obtained a higher performance in TUG test (p = 0.003 as the risk categories were observed. Reduced visual acuity and difficulty in getting up were more frequently reported in G1 (p < 0.05. CONCLUSION: There appears to be an association between hyperglycemic status and poorer mobility, with an increased fall risk even in younger patients and in those with shorter disease duration.

  16. Amamentação ao seio, amamentação com leite de vaca e o diabetes mellitus tipo 1: examinando as evidências Breast- feeding, bottle- feeding and the type 1 diabetes mellitus: examining the evidences

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    Suely Godoy Agostinho Gimeno

    1998-04-01

    Full Text Available A etiologia do diabetes mellitus tipo 1 (DM1 envolve tanto herança genética como a exposição a fatores ambientais. Evidências de estudos epidemiológicos e experimentais sugerem que a dieta pode ser importante na etiopatogenia dessa doença. Em 1984, Borch-Johnsen e col. sugeriram, com base nos resultados de um estudo caso-controle, que o leite materno seria um fator de proteção para o DM1; esse efeito se daria devido às propriedades anti-infecciosas desse tipo de leite, ou pelo fato de que a amamentação ao seio evitaria que as crianças pudessem ser precocemente expostas a outros agentes etiológicos contidos nos substitutos do leite materno. Esses mesmos achados foram poste-riormente encontrados em diversos estudos, mas o papel do leite materno no aparecimento do DM1 ainda permanece controverso. Em 1992, Karjalainen e col., ao compararem os soros de indivíduos com e sem DM1, observaram, entre os diabéticos, altas concentrações de anticorpos anti-albumina bovina. Os autores postularam a hipótese de que a albumina bovina poderia atuar como desencadeadora do processo destrutivo das células ß do pâncreas e, conseqüentemente, do diabetes. Resultados conflitantes foram observados nas publicações que se sucederam a essa. Neste artigo, resumem-se e discutem-se os achados de diferentes pesquisadores que investigaram a importância desses fatores dietéticos para o aparecimento do DM1.The aetiology of type 1 diabetes mellitus (DM1 includes genetic heritage and environmental exposure. Evidence from animal and epidemiological studies suggests that some diet components may play a role in the aetiology of DM1. In 1984, Borch-Johnsen et al. suggested, based on a case-control study, that breast-feeding was a protective factor for DM1, probably due its anti-infectious properties or because breast-feeding delays exposure to other etiologic agents in the diet. Afterwards, the same results were found in several studies but the role of breast

  17. Bomba de infusão de insulina em diabetes melito tipo 1 Insulin pump therapy in type 1 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Raphael Del Roio Liberatore Jr.

    2006-08-01

    Full Text Available OBJETIVO: Rever a experiência com a utilização da bomba de infusão de insulina em crianças e adolescentes, a fim de orientar o pediatra quanto às suas indicações e complicações. FONTE DOS DADOS : Foi realizada revisão sistemática de artigos publicados em literatura que abordassem a utilização da bomba de infusão de insulina, suas indicações, complicações e resposta ao tratamento. Dessa forma, todos os artigos publicados entre 1995 e 2005 foram resgatados através do levantamento em banco de dados MEDLINE e LILACS. As palavras-chave utilizadas foram: insulin pumps, type 1 diabetes mellitus e diabetes mellitus. Foram separados os artigos que, além disso, versassem sobre o assunto na faixa etária descrita SÍNTESE DOS DADOS: O uso da bomba de infusão de insulina em pacientes com diabetes melito tipo 1 não é uma necessidade para todos os pacientes, visto que, com tratamentos intensivos, os resultados conseguidos são muito parecidos, em termos de hemoglobina glicada e de controle de complicações a médio e longo prazo. No entanto, a bomba permite um maior conforto ao paciente, no sentido de que ele não precisa ficar tão restrito a horários rígidos de refeição e pode levar uma vida com melhor qualidade. Um primeiro requisito para quem pretenda usar a bomba é adaptar-se a aparelhos conectados ao corpo e a ter uma rotina de monitorização glicêmica rigorosa, pois, sem isso, as vantagens da bomba serão anuladas. As complicações, com os avanços tecnológicos de que dispomos atualmente, são muito infreqüentes. O custo, no entanto, é maior que nos tratamentos convencionais. CONCLUSÃO: Com a evolução das bombas de infusão e dos monitores de glicemia, incluindo sistemas de monitorização contínua, abre-se caminho para as "bombas inteligentes", e estaremos com um verdadeiro "pâncreas artificial", que pode mesmo ser implantado no paciente, permitindo uma vida com todas as regalias de uma pessoa não diab

  18. Oral Candida spp carriers: its prevalence in patients with type 2 Diabetes Mellitus Portadores de Candida spp na cavidade oral: a sua prevalência em pacientes com diabetes mellitus tipo 2

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    Ramon Felipe Fernandez Martinez

    2013-04-01

    Full Text Available BACKGROUND: Prevalence of oral candidiasis in diabetic patients is 13.7-64%. Candida albicans was the most frequently isolated species (75-86.5%. OBJECTIVE: To obtain the prevalence of Candida carriers among patients with type 2 diabetes mellitus to identify the species of the yeast. Study design: It is an open, observational, descriptive, cross-sectional, and prospective study. METHODS: We included voluntary patients from the National Diabetes Marathon and performed a blood glucose measurement, sialometry test, Gram-stained exfoliative cytology, and culture on Sabouraud dextrose agar and CHROMagar Candida TM. Results were analyzed using descriptive statistics. RESULTS: We examined 141 patients (mean age 57 years: 103 women (73% and 38 men (26.9%. Exfoliative cytology was positive in 32 cases (23 with oral lesions; 78 had oral lesions but no Candida (93.9%. Candida was isolated in 58 patients (41.1%, 21 (45.6 % had blood glucose greater than 126 mg/dl, and 37 (38.9% had less than 126 mg/dl. The most frequent species was C. albicans (82.7%. Forty-two Candida carriers had salivary flow greater than 20 mm (72.4%, and 16 (27.5% had hyposalivation. Candida was isolated in 25 of 79 patients with dental prosthesis (31.6%, 9 of 15 were smokers (60%, and 22 of 71 had symptoms (30.9%. CONCLUSIONS: Prevalence of oral Candida carriers in patients with type 2 diabetes mellitus in Mexico was similar to that found in other countries; exfoliative cytology was effective in finding Candida; salivary flow rate, use of prosthesis, and presence of oral lesions and symptoms were similar in oral Candida carriers and negative patients. Most smokers were Candida carriers. FUNDAMENTOS: A prevalência de candidíase oral em pacientes diabéticos é de 13,7- 64%. A espécie mais frequentemente isolada é Candida albicans(75-86,5%. OBJETIVO: Obter a prevalência de portadores de Candida em pacientes com diabetes mellitus tipo 2 para identificar as espécies da levedura

  19. Percepción de los Beneficios de la Tenencia de Animales de Compañía para las Personas de la Mediana Edad con Diabetes Mellitus Tipo 2

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    Hugues H., Beatriz; Álvarez Á., Aimee M.; Castelo E., Lizet; Ledón L., Loraine; Mendoza T., Madelín; Domínguez A., Emma

    2016-01-01

    Se efectuó un estudio con el objetivo de explorar la percepción de personas de la mediana edad con Diabetes Mellitus Tipo 2 (DM2) respecto a la tenencia de animales de compañía y su relación con la satisfacción personal, beneficios sobre la salud psicoemocional, el control metabólico y la motivación para la realización de actividades físicas. El estudio fue de tipo transversal, descriptivo, con 85 personas de 40 a 59 años de edad con DM2 y residentes en La Habana, Cuba. Se confeccionó un cues...

  20. Human leukocyte antigen class II susceptibility conferring alleles among non-insulin dependent diabetes mellitus patients

    International Nuclear Information System (INIS)

    Tipu, H.N.; Ahmed, T.A.; Bashir, M.M.

    2010-01-01

    To determine the frequency of Human Leukocyte Antigen (HLA) class II susceptibility conferring alleles among type 2 Diabetes mellitus patients, in comparison with healthy controls. Cross-sectional comparative study. Patients with non-insulin dependent Diabetes mellitus meeting World Health Organization criteria were studied. These were compared with age and gender matched healthy control subjects. For each subject (patients as well as controls), DNA was extracted from ethylene diamine tetra-acetate sample and HLA class II DRB1 typing was carried out at allele group level (DRB1*01-DRB1*16) by sequence specific primers. Human leukocyte antigen DRB1 type was determined by agarose gel electrophoresis and results were recorded. Frequencies were determined as number of an allele divided by total number of alleles per group; p-value was computed using Pearson's chi-square test. Among the 100 patients, there were 63 males and 37 females with 68 controls. A total of 13 different HLA DRB1 alleles were detected, with DRB1*15 being the commonest in both the groups. The allele DRB1*13 had statistically significant higher frequency in patient group as compared to controls (p 0.005). HLA DRB1*13 was found with a significantly increased frequency in non-insulin dependent Diabetes mellitus. (author)

  1. La retinopatía diabética como predictor de morbi-mortalidad cardiovascular en pacientes con diabetes mellitus tipo 2 en un área de 70.000 habitantes de nuestra comunidad

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    Blasco Lamarca, Yolanda; Gimeno Orna, José Antonio; Faure Nogueras, Eduardo Jaime

    2013-01-01

    El elevado incremento en la morbi-mortalidad cardiovascular de los pacientes diabéticos, ha planteado la necesidad de búsqueda de marcadores de riesgo vascular. La presencia de retinopatía diabética podría ser un predictor independiente de riesgo de enfermedad cardiovascular. En una muestra de 463 pacientes con diabetes mellitus tipo 2 de nuestra comunidad autónoma hemos evaluado la relación entre la valoración inicial del fondo de ojo y la aparición de eventos cardiovasculares. Tras un seg...

  2. Reduced glomerular angiotensin II receptor density in diabetes mellitus in the rat: time course and mechanism

    International Nuclear Information System (INIS)

    Wilkes, B.M.

    1987-01-01

    Glomerular angiotensin II receptors are reduced in number in early diabetes mellitus, which may contribute to hyperfiltration and glomerular injury. The time course and role of the renin-angiotensin-aldosterone system in the pathogenesis of the receptor abnormality were studied in male Sprague-Dawley rats made diabetic with streptozotocin (65 mg, iv). Glomerular angiotensin II receptors were measured by Scatchard analysis; insulin, renin activity, angiotensin II, and aldosterone were measured by RIA. Diabetes mellitus was documented at 24 h by a rise in plasma glucose (vehicle-injected control, 133 +/- 4; diabetic, 482 +/- 22 mg/dl and a fall in plasma insulin (control, 53.1 +/- 5.7; diabetic, 35.6 +/- 4.0 microIU/ml. At 24 h glomerular angiotensin II receptor density was decreased by 26.5% in diabetic rats (control, 75.5 +/- 9.6 X 10(6); diabetic, 55.5 +/- 8.3 X 10(6) receptors/glomerulus. Receptor occupancy could not explain the defect, because there was reduced binding in diabetic glomeruli after pretreatment with 3 M MgCl 2 , a maneuver that caused dissociation of previously bound hormone. There was a progressive return of the receptor density toward normal over the 60 days following induction of diabetes, with diabetic glomeruli measuring 22.7%, 14.8%, and 3.7% fewer receptors than age-matched controls at 11 days, 1 month, and 2 months, respectively

  3. Determinantes sociales frente a estilos de vida en la diabetes mellitus de tipo 2 en Andalucía: ¿la dificultad para llegar a fin de mes o la obesidad? Social determinants vs. lifestyle in type 2 diabetes mellitus in Andalusia (Spain: difficulty in making ends meet or obesity?

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    Antonio Escolar Pujolar

    2009-10-01

    Full Text Available Objetivo: Valorar las relaciones de la dificultad para llegar a fin de mes con la obesidad y la diabetes mellitus de tipo 2 en Andalucía. Métodos: Estudio transversal basado en los datos de la Encuesta de Salud de Andalucía-2003. Cálculo de prevalencias y odds ratio (OR de tener diabetes mellitus de tipo 2 según variables de estilo de vida, y de obesidad y diabetes mellitus de tipo 2 según la dificultad autopercibida para llegar a fin de mes. Resultados: La OR ajustada por edad de tener diabetes mellitus de tipo 2 en personas obesas respecto a las de peso normal fue de 2,52 (intervalo de confianza del 95% [IC95%]:1,63-3,88 y de 2,13 (IC95%:1,28-3,54 en las mujeres y los hombres, respectivamente. El sedentarismo no se asoció con un riesgo significativo de diabetes mellitus de tipo 2 en ninguno de los dos sexos. Para las mujeres con mayor dificultad económica para llegar a fin de mes, respecto a las que tienen más facilidades, la OR de ser obesa, ajustada por edad y ejercicio físico, fue de 3,03 (IC95%:1,96-4,66, y la de diabetes mellitus de tipo 2, ajustada por edad, ejercicio físico e índice de masa corporal, fue de 2,55 (IC95%:1,28-5,10. En los hombres ninguna de las OR fue estadísticamente significativa. Conclusión: En las mujeres, las dificultades para llegar a fin de mes reflejan un contexto socioeconómico favorecedor de obesidad y de diabetes mellitus de tipo 2. Las desigualdades de clase social y género identificadas pueden contribuir a ampliar el actual marco explicativo de los determinantes de la diabetes mellitus de tipo 2, excesivamente centrado en las conductas individuales. La dificultad autopercibida para llegar a fin de mes podría utilizarse como indicador de pobreza en los estudios de desigualdades en salud.Objective: To assess the relationship between difficulty in making ends meet and obesity and type 2 diabetes mellitus in Andalusia. Methods: We performed a cross-sectional survey based on the Andalusian Health

  4. Síndrome nefrótica córtico-sensível e diabetes mellitus tipo 1 de início simultâneo Simultaneous onset of steroid-sensitive nephrotic syndrome and type 1 diabetes

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    Eduardo A. Rego Filho

    2003-11-01

    Full Text Available OBJETIVO: Apresentação de um caso de ocorrência simultânea de síndrome nefrótica córtico-sensível e diabetes mellitus tipo 1. A raridade da associação dessas duas doenças, os sintomas clínicos e os exames laboratoriais que confirmaram o diagnóstico, bem como as dificuldades no tratamento com corticóides, tornam este caso de grande interesse. DESCRIÇÃO: Um menino de 3 anos e 11 meses iniciou edema progressivo até anasarca. Confirmado diagnóstico de síndrome nefrótica, iniciou tratamento com prednisona 2 mg/kg/dia. Após três semanas de tratamento, observaram-se importante perda de peso, de 23 kg para 16 kg, poliúria, polidipsia e apatia. Exames laboratoriais evidenciaram hiperglicemia, 657 mg/dl, glicosúria sem proteinúria, acidemia e cetonúria. Com o diagnóstico de cetoacidose diabética, iniciou-se insulinoterapia associada a prednisona. Permaneceu com dose diária de NPH. Aos quatro anos e um mês, apresentou novo episódio de cetoacidose associado a infecção das vias aéreas superiores e sem proteinúria. Teve recaída da síndrome nefrótica aos quatro anos e quatro meses, com boa resposta a prednisona. Nova recaída após três meses, durante retirada de prednisona, optando-se por iniciar ciclofosfamida diária associada a prednisona em dias alternados, com normalização da proteinúria. Permanece em remissão, atualmente com cinco anos e seis meses, recebendo insulina diariamente. Outros exames revelaram C3 e C4 séricos normais, função renal normal, hematúria microscópica ocasional, anticorpos anti-GAD (descarboxilase glutâmica normais; anticorpos antiilhotas positivos. A tipagem HLA classes I e II forneceu os seguintes resultados: A2; B44, B52; DR4, DR8, DR53. COMENTÁRIOS: A ocorrência simultânea de síndrome nefrótica córtico-sensível e diabetes mellitus tipo 1 é muito rara. Os autores discutem os dados de literatura, o padrão familiar e os estudos de HLA.OBJECTIVE: We describe the case of a boy

  5. Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and Obesity

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    Mostafa Wanees Ahmed El husseny

    2017-01-01

    Full Text Available Adipokines are bioactive molecules that regulate several physiological functions such as energy balance, insulin sensitization, appetite regulation, inflammatory response, and vascular homeostasis. They include proinflammatory cytokines such as adipocyte fatty acid binding protein (A-FABP and anti-inflammatory cytokines such as adiponectin, as well as vasodilator and vasoconstrictor molecules. In obesity and type II diabetes mellitus (DM, insulin resistance causes impairment of the endocrine function of the perivascular adipose tissue, an imbalance in the secretion of vasoconstrictor and vasodilator molecules, and an increased production of reactive oxygen species. Recent studies have shown that targeting plasma levels of adipokines or the expression of their receptors can increase insulin sensitivity, improve vascular function, and reduce the risk of cardiovascular morbidity and mortality. Several reviews have discussed the potential of adipokines as therapeutic targets for type II DM and obesity; however, this review is the first to focus on their therapeutic potential for vascular dysfunction in type II DM and obesity.

  6. The treatment of gastroesophageal reflux disease in menopausal women suffering from diabetes mellitus type II

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    Semikina Т.М.

    2016-12-01

    Full Text Available Purpose: to develop criteria for the selection of optimal tactics of supporting treatment of nonerosive gastroesophageal reflux disease with proton pump inhibitors in menopausal women suffering from diabetes mellitus type II. Material and Methods. 186 patients aged 45-59 who suffer from gastroesophageal reflux disease have been followed up, 46 of which suffer from diabetes mellitus type II as well. The climacteric syndrome's morbidity has been assessed in accordance with the modified menopause index; the level of glycated hemoglobin has been measured by the Abbott analyzer produced in the USA. Results. It is established that irrespective of the supporting treatment, the gastroesophageal reflux disease remittance was shorter in direct proportion with increase of the HbA1c level and the value of the modified menopause index in menopausal women suffering from diabetes mellitus type II. Conclusion. When the climacteric syndrome was mild or moderate, taking 20 mg Omeprazole once a day and "on demand" has comparable results, therefore this group of women prefer the "on demand" regimen as it lowers the risk of osteoporosis progression and further bone fracture. Taking 20 mg Omeprazole once a day, every other day, and "on demand" allows the disease remittance to prolong for a year and longer in less than 30% of women suffering from severe climacteric syndrome and having HbA1c>9.0%; however, this number may grow up to 70% of women in case they follow medical advice and reduce their carbohydrate input to 11 carbohydrate units and less.

  7. Cooperación transfronteriza en investigación sobre diabetes mellitus tipo 2: México-Estados Unidos U.S.-Mexico cross-border cooperation in research on diabetes mellitus type 2

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    Jaume Canela-Soler

    2010-09-01

    Full Text Available OBJETIVO: Describir y analizar con un enfoque de estudio de caso el Proyecto de Prevención y Control de la Diabetes en la Frontera México-Estados Unidos (PDF-México/Estados Unidos, un esfuerzo de cooperación en investigación en salud en el que participaron instituciones federales, estatales y locales de ambos países. MÉTODOS: El proyecto utilizó un modelo de igual representación, participación, consenso y liderazgo compartido, con la participación de más de 130 instituciones coordinadas por organismos de ambos países. Se estudió una muestra aleatoria, multietápica, estratificada y por conglomerados de 4 020 personas mayores de 18 años que respondieron un cuestionario de preguntas relacionadas con la diabetes mellitus tipo 2 (DM2 y la salud. El análisis estadístico de la información muestral obtenida tuvo en cuenta el efecto del diseño. RESULTADOS: La prevalencia de DM2 diagnosticada fue de 14,9% (intervalo de confianza de 95% [IC95%]: 12,5-17,6 y la prevalencia de DM2 diagnosticada ajustada por edad fue de 19,5% (IC95%: 16,8-22,6 en la parte mexicana y de 16,1% (IC95%: 13,5-19,2 en la estadounidense. La prevalencia de la DM2 y los factores de riesgo no fueron exactamente iguales a lo largo de la frontera. CONCLUSIONES: La ejecución del PDF-México/Estados Unidos ha permitido por primera vez considerar la franja fronteriza entre ambos países como una unidad para la investigación epidemiológica. En iniciativas fronterizas futuras, se sugiere fortalecer el entendimiento mutuo de la estructura sociopolítica y de las formas de actuación por parte de las instituciones y otras entidades participantes en ambos lados de la frontera.OBJECTIVE: To describe and analyze, utilizing a case study approach, the U.S.- Mexico Border Diabetes Prevention and Control Project, a health research cooperation initiative incorporating the participation of federal, state, and local institutions of both countries. METHODS: A model of equal

  8. Maduración sexual en niños con diabetes mellitus tipo 1 tratados con dosis múltiples de insulina Sexual maturation in children presenting with Type 1 diabetes mellitus treated with multiple dose of insulin.

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    Tania Espinosa Reyes

    2007-04-01

    Full Text Available Antes de la terapia insulínica, la menarquia y menstruaciones subsecuentes aparecían raramente en niñas con diabetes mellitus tipo 1 (DM 1 desde la infancia, y en los varones se verificaba un importante retraso puberal. El objetivo del presente trabajo es evaluar el inicio de la pubertad, y la influencia de la edad de diagnóstico de la diabetes y el grado de control metabólico, sobre el desarrollo sexual en un grupo de ninos atendidos en consultas de endocrinología pediátrica. Se realizó un estudio prospectivo no concurrente a partir de las historias clínicas de pacientes tratados con dosis múltiples de insulina, de procedencia urbana (32 varones y 28 hembras, seguidos longitudinalmente por examen clínico y determinaciones bioquímicas periódicas desde el inicio de la DM 1 hasta alcanzar su talla final. El control metabólico fue evaluado a través de la hemoglobina glicosilada (HbA1 realizada trimestralmente, y clasificado según criterios de la institución en bueno (B: 10 %. La media de la edad a la que se encontró un volumen testicular de 4 mL fue 12,5 ± 0,8 años; en las niñas el inicio del desarrollo mamario se constató a la edad promedio de 11,4 ± 1,3 años y la menarquia ocurrió a los 12,9 ± 1,2 años. Se comprobó también que 31 pacientes tuvieron un control metabólico B (51,6 %, 22 R (36,7 % y 7 M (11,7 %. Se concluye que el tratamiento con dosis múltiples de insulina tiene una influencia favorable y decisiva sobre el grado de control metabólico, lo cual hace posible un desarrollo puberal adecuado en pacientes con DM 1.Before insulin therapy, menarche and subsequent menstruation rarely appear in girls presenting Type 1 diabetes mellitus (MD 1 from childhood, and in boys a significicant pubertal retardation was confirmed. Aim of present paper is to assess onset of puberty, influence of diagnosis age of diabetes, and degree of metabolic control, on sexual development in a cohort of children seen in service of

  9. Síndrome metabólico en familiares de primer grado de pacientes con diabetes mellitus tipo 2 Metabolic syndrome in first degree relatives of patients with diabetes mellitus 2

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    Raúl Orlando Calderín Bouza

    2005-12-01

    Full Text Available Se realizó un estudio descriptivo y transversal de 340 personas divididas en 2 grupos, con y sin antecedentes patológicos familiares de diabetes mellitus tipo 2 (APF de DM2, con el objetivo de detectar si las que presentaban APF de DM2 tenían más hiperinsulinemia, presencia de síndrome metabólico, factores de riesgo cardiovascular asociados y lesión de órganos diana, expresados en hipertrofia del ventrículo izquierdo de los sujetos que no tenían dicho antecedente. Se obtuvo como resultado que la hiperinsulinemia estuvo presente en 96 pacientes con APF de DM2 (56,5 % y una significación de p = 0,001. El síndrome metabólico fue más frecuente en las personas con APF DM2 (90 para un 52,9 % y una significación de p = 0,000. La hipertrigliceridemia fue el marcador por excelencia del síndrome metabólico y el factor de riesgo que con más significación estadística se asoció a los sujetos con APF de DM2 (96: 52,9 % y una significación de p = 0,000. La hipertrofia ventricular izquierda (HVI se asoció como expresión de lesión de órganos diana a los sujetos con APF de DM2 (36: 21,2 % y una significación de p = 0,043. Concluimos que los sujetos con APF de DM2 son más propensos a tener hiperinsulinemia, al síndrome metabólico, a factores de riesgo cardiovascular y a lesión de órgano diana en comparación con los que no tienen dicho antecedente.A cross-sectional descriptive study of 340 persons assigned to two groups, with and without family history of diabetes mellitus type 2 (DM2, was carried out. The objective was to detect whether those persons with family history of DM2 had more hyperinsulemia, metabolic syndrome, associated cardiovascular risk factors and target organ lesions, expressed in left ventricle hypertrophy, than subjects without diabetes family history. The result was that hyperinsulemia was present in 96 patients with family history of DM2 (56,5 % and significance level of p= 0,001. Metabolic syndrome was more

  10. Estudo Comparativo dos Resultados Maternos e Perinatais entre Pacientes com Diabetes Pré-gestacional Tipo I e Tipo II Comparative Study of Maternal and Perinatal Outcomes among Patients with Pregestational Type I and Type II Diabetes

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    Micheline Monte de Carvalho

    2000-06-01

    Full Text Available Objetivos: avaliar a evolução da gestação, controle metabólico e resultados perinatais de pacientes diabéticas pré-gestacionais e fazer um estudo comparativo entre os resultados de pacientes com diabetes insulino-dependente e não-insulino-dependente. Métodos: análise retrospectiva de prontuários de 57 pacientes com diagnóstico de diabetes pré-gestacional que iniciaram pré-natal no Serviço de Medicina Materno-Fetal da Maternidade-Escola Assis Chateaubriand da Universidade Federal do Ceará, no período de janeiro 1995 a dezembro de 1998. As 57 grávidas incluídas no estudo foram divididas em dois grupos: grupo I, composto de 28 pacientes portadoras de diabetes insulino-dependente (tipo I, e grupo II, com 29 gestantes com diabetes não-insulino-dependente (tipo II controladas com dieta ou com hipoglicemiante oral antes da gestação. Resultados: não houve diferença estatisticamente significante entre os dois grupos em relação à necessidade de internamento para controle glicêmico (39,2% x 27,5% e complicações maternas, tais como: hipertensão arterial crônica (14,2% x 27,5%, doença hipertensiva específica da gravidez (14,2% x 17,2%, amniorrexe prematura (3,5% x 10,3%, infecção do trato urinário (10,7% x 6,8% e trabalho de parto prematuro (3,5% x 6,8%. Foi observado, porém, maior número de episódios de hipoglicemia materna entre as pacientes insulino-dependentes (35,7% x 3,4%. Os resultados perinatais foram semelhantes. Observamos elevados índices de malformações e morbimortalidade perinatal. Conclusão: não houve diferença na incidência de intercorrências clínicas e obstétricas entre as pacientes insulino-dependentes e não-insulino-dependentes, excluindo-se hipoglicemia materna.Purpose: to evaluate the evolution of gestation, metabolic control and perinatal outcome of pregestational diabetic patients and to perform a comparative study of the results of patients with insulin-dependent diabetes (type I and

  11. Transplante de células-tronco hematopoéticas no diabete melito do tipo I Autologous hematopoietic stem cell transplantation in type I diabetes mellitus

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    Júlio C. Voltarelli

    2004-03-01

    Full Text Available Transplantes autólogos de células-tronco hematopoéticas (TACTH para doenças auto-imunes (DAÍ graves e refratárias à terapia convencional têm sido realizados desde 1996, principalmente dirigidos a doenças reumáticas e neurológicas, com resultados encorajadores. De modo geral, dois terços dos pacientes alcançam remissão duradoura da doença auto-imune, embora a morbimortalidade relacionada ao transplante ou à recidiva e progressão da DAI ainda constituam problemas significativos. Baseados nesses resultados e no efeito benéfico da imunossupressão moderada na evolução do diabete melito do tipo I (DM-I, iniciamos, em dezembro de 2003, um protocolo clínico de TACTH para esta doença, em cooperação com a Universidade Northwestern de Chicago, da Universidade de Miami e do National Institutes of Health. Pacientes com DM-I abaixo de 35 anos, diagnosticados há menos de seis semanas ou na fase assintomática ("lua-de-mel" da doença têm suas CTH mobilizadas com ciclofosfamida (2 g/m² e G-CSF, coletadas do sangue periférico e criopreservadas. Após o condicionamento com ciclofosfamida (200 mg/kg e globulina antitimocitária de coelho (4,5 mg/kg e a infusão das CTH autólogas, os pacientes são seguidos por cinco anos em relação aos aspectos clínicos, endocrinológicos e imunológicos do diabete. Este estudo clínico poderá representar uma importante contribuição científica do transplante de medula óssea brasileiro à moderna era de terapia celular de doenças inflamatórias e degenerativas.Autologous hematopoietic stem cell transplantation (AHSCT for severe and refractory autoimmune diseases has been performed since 1996 with encouraging results. In general, two thirds of the patients achieve durable remissions, although morbidity and mortality related to transplantation or to relapse and progression of autoimmune diseases are still significant. Based on those results and on beneficial effects of moderate immunosuppression

  12. Asociación de polimorfismos en DNA mitocondrial y diabetes mellitus tipo 2 Descriptive study of the current status of the pediatric practice in Antioquia

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    Gabriel Bedoya Berrío

    2003-01-01

    Full Text Available

    La Diabetes mellitus tipo 2 (DM2 es un trastorno metabólico
    caracterizado por una marcada resistencia a la insulina en los tejidos blanco; la prevalencia de DM2 presenta grandes diferencias en poblaciones humanas; es muy alta en aquéllas originadas por migraciones que han cambiado su etilo de vida; alcanza niveles hasta del 30% en poblaciones de americanos nativos como los Pima, que presentan la incidencia más alta en el ámbito mundial (1, en contraste con la población británica que sólo alcanza el 2%. Para explicar este fenómeno James Neel propuso la hipótesis del ";;;;genotipo económico";;;; en la cual sugiere que el genotipo que confiere susceptibilidad a DM2 acompañada de obesidad, aparece en los humanos como un genotipo con ventajas evolutivas para períodos de escasez de alimentos, pero es desventajoso cuando la población entra a períodos de abundancia.


    Con el fin de probar el efecto que el DNA mitocondrial (mtDNA, puede tener en el genotipo económico nos propusimos evaluar la asociación de polimorfismos en mtDNA y DM2, comparando estadísticamente las frecuencias alélicas y haplotípicas de locipolimórficos en el mtDNA entre un grupo de casos y un grupo control para DM2 en población antioqueña.

    BACKGROUND: Even though the implementation of the Law 100 of 1993 has given rise to profound changes in the medical attention services and working conditions of health service personnel, there are few studies that explore the impact on the latter. The purpose of the present study was to describe the current situation of pediatricians and pediatric subspecialists in Antioquia during the 2004-2005 period, with emphasis on social, workrelated and economic factors. MATERIALS AND METHODS: Crossing the data bases of the Pediatrics Society of Antioquia and some pharmaceutical companies, a universe of 321 pediatricians was obtained, from which 220 were randomly interviewed. RESULTS AND CONCLUSIONS: The resulting

  13. Manifestações vestibulococleares em pacientes com diabetes melito tipo I Vestibulocochlear manifestations in patients with type I diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Karlin Fabianne Klagenberg

    2007-06-01

    Full Text Available Ometabolismo da glicose tem muita influência na fisiologia da orelha interna e pequenas variações glicêmicas podem provocar alterações na audição e no equilíbrio corporal. OBJETIVO: Verificar as manifestações vestibulococleares em pacientes com diabetes melito tipo I. FORMA DE ESTUDO: Coorte contemporânea com corte transversal. MATERIAL E MÉTODO: Avaliaram-se 30 pacientes (17 homens e 13 mulheres encaminhados do Hospital de Clínicas da UFPr para o Laboratório de Otoneurologia da Universidade Tuiuti do Paraná no período de março/2004 a fevereiro/2005. Realizaram-se os seguintes procedimentos: anamnese, inspeção otológica, avaliação audiológica convencional, medida de imitância acústica e avaliação vestibular. RESULTADOS: Observaram-se entre as queixas otoneurológicas a prevalência de cefaléia (23,3%, tontura rotatória (16,6% e zumbido (13,3%. Nas queixas associadas e hábitos, a prevalência foi do abuso de cafeína (20,0%, álcool e alergia (10,0%, em cada. Houve prevalência de limiares auditivos normais (90,0%. A medida de imitância acústica mostrou-se sem alteração. O exame vestibular esteve alterado em 60,0%. Houve predomínio das síndromes vestibulares periféricas deficitárias. CONCLUSÕES: Verificou-se um maior número de alteração do sistema vestibular (60,0% em relação ao sistema auditivo (10,0%. Houve predomínio da normalidade no exame auditivo. Houve prevalência de alteração no sistema vestibular periférico e da síndrome vestibular periférica deficitária.Glucose metabolism has a significant impact on inner ear physiology, and small changes may result in hearing and balance disorders. AIM: To investigate vestibulocochlear symptoms in patients with type I diabetes mellitus. STUDY DESIGN: a cross-sectional study of a contemporary group. MATERIAL AND METHOD: 30 patients referred from Clinical Hospital-UFPR to the Laboratory of Otoneurology-UTP between Mar/2004 to Feb/2005 were evaluated

  14. Lifestyle changes in descendants of parents with diabetes type 2 Cambio en los patrones de vida en descendientes de progenitores con diabetes mellitus tipo 2 del noreste de Mexico Mudança em os padrões de vida em descendentes de progenitores com diabetes mellitus tipo 2 do nordeste do México

    Directory of Open Access Journals (Sweden)

    Rosalinda Guerra-Juárez

    2007-10-01

    Full Text Available This study aimed to explore the disposition of diabetic parents' descendents in changing eating and physical activity patterns. It was based on the heritability concept and Prochaska's Transtheoretical Model. This is a descriptive-correlational study; participants included 30 parents, randomly selected, and 60 children. Results and conclusion: 68% of the children was classified as obese, 42% with insulin resistance, and 15% with carbohydrate intolerance. None of the risk factors was associated with the stages of change. The heritability factor was 1.37%; more people younger than 40 and women report decreasing in the consumption of fat food (Xi² = 6.04, p = .020; and 4.41, p = .040, respectively. These results suggest a high influence of environmental factors on the participants' unhealthy life styles.El objetivo general del estudio fue explorar la disposición al cambio de patrones alimentarios y actividad física en descendientes de progenitores con diabetes mellitus tipo 2 (DMT2, aplicando un diseño descriptivo correlacional. La base teórica la constituyó el componente genético heredabilidad (h² y el Modelo Transteorético de Prochaska; participaron 30 progenitores con DMT2 y 60 descendientes. Resultados y Conclusión: El 68% de los descendientes fueron obesos, 60% con riesgo de enfermedad cardiovascular, 42% con resistencia a la insulina (RI y 15% intolerantes a la glucosa; ninguno de los factores de riesgo se asoció con las etapas de cambio. El componente genético para RI fue mínimo (h² = 1.37%. Una mayor proporción de menores de 40 años (p = .020 y de mujeres "contemplan" disminuir el consumo de grasas (p = .040. Estos resultados sugieren un mayor peso de factores del medio ambiente sobre el estilo de vida nocivo de los participantes.O objetivo geral do estudo foi explorar à disposição à mudança dos padrões alimentares e atividade física nos descendentes de progenitores com diabetes mellitus tipo 2 (DMT2. Aplicou-se un

  15. Cryptococcosis in patients with diabetes mellitus II in mainland China: 1993-2015.

    Science.gov (United States)

    Li, Yingfang; Fang, Wenjie; Jiang, Weiwei; Hagen, Ferry; Liu, Jia; Zhang, Lei; Hong, Nan; Zhu, Yu; Xu, Xiaoguang; Lei, Xia; Deng, Danqi; Xu, Jianping; Liao, Wanqing; Boekhout, Teun; Chen, Min; Pan, Weihua

    2017-11-01

    Diabetes mellitus II (DM II) is a newly defined independent factor contributing to the morbidity and mortality of cryptococcosis. This retrospective case analysis aims to explore the epidemiology, clinical profile and strain characteristics of cryptococcosis in Chinese DM II patients. This study included 30 cases of cryptococcosis with DM II occurring from 1993 to 2015 in mainland China. The hospital-based prevalence of cryptococcosis in DM II was 0.21%. The mean age of the patients was 56.1 years (95% confidence interval: 51.5, 60.6), and 93% of the patients were older than 40 years. Sixty-two per cent of the patients experienced untreated or poorly controlled blood glucose before infection. Multilocus sequence typing analysis categorised all cultured strains as Cryptococcus neoformans and sequence type 5. Sixty-nine per cent of pulmonary cryptococcosis patients experienced misdiagnoses and treatment delays. Sixty per cent of cryptococcal meningitis patients received substandard antifungal therapy. The overall death rate was 33%. Considering the large population size of DM II patients in China, improved attention should be paid to the high prevalence of cryptococcosis as revealed by us. We also emphasised the importance of blood glucose control for infection prevention, especially among the elderly. © 2017 Blackwell Verlag GmbH.

  16. Prevalencia de enfermedad cardiovascular en personas recién diagnosticadas de diabetes mellitus tipo 2 Cardiovascular disease prevalence in recent diagnosed type 2 diabetic patients

    Directory of Open Access Journals (Sweden)

    Manuel Mata-Cases

    2009-04-01

    Full Text Available Objetivo: Conocer la prevalencia de la enfermedad cardiovascular en el momento del diagnóstico de la diabetes mellitus tipo 2. Métodos: Estudio observacional retrospectivo realizado en un centro de atención primaria urbano entre 1991 y 2000. Revisión de las características clínicas, factores de riesgo y enfermedad cardiovascular el año del diagnóstico de diabetes. Se excluyeron los pacientes sin glucemias previas al diagnóstico. Se realizó un análisis de regresión logística para identificar las variables asociadas a la presencia de eventos cardiovasculares. Resultados: De los 598 nuevos casos de diabetes diagnosticados se analizaron los 487 que tenían valores previos de glucemia (media de edad [desviación estándar]: 60,4 [10,9] años; un 53% eran mujeres. La prevalencia de factores de riesgo cardiovascular fue: obesidad 61,1%, hipertensión arterial 71,9%, hipercolesterolemia 52%, hipertrigliceridemia 35,3% y tabaquismo actual 24% o previo 16,6%. El 96,9% tenía algún factor de riesgo cardiovascular y el 53,4% tres o más. Un total de 78 pacientes presentaron enfermedad cardiovascular anterior o detectada durante el primer año de diagnóstico (16%; intervalo de confianza del 95%[IC95%]: 12,8-19,3; varones 21,4% y mujeres 11,2%. La prevalencia de enfermedad cardiovascular aumentó con el número de factores de riesgo cardiovascular. El análisis de regresión logística mostró una asociación de la enfermedad cardiovascular y la edad >55 años (odds ratio [OR]=2,91; IC95%: 1,46-5,80, el tabaquismo (OR=2,28; IC95%: 1,15-4,51 y los valores de hemoglobina glucosilada (HbA1c >7% (OR=1,85; IC95%: 1,10-3,1. Conclusiones: Se observa una elevada prevalencia de factores de riesgo y enfermedad cardiovascular en el momento del diagnóstico de la diabetes; la edad, el tabaquismo y la HbA1c son las variables relacionadas con la enfermedad cardiovascular.Objective: To determine the prevalence of cardiovascular disease at diagnosis of type 2

  17. The perspectives of Brazilian homemakers concerning living with type 2 diabetes mellitus La perspectiva de ama de casa brasileña sobre la vida con diabetes mellitus tipo 2 As perspectivas de donas de casa brasileiras sobre a sua experiência com diabetes mellitus tipo 2

    OpenAIRE

    Denise Maria Guerreiro Vieira da Silva; Kathy Hegadoren; Gerri Lasiuk

    2012-01-01

    The purpose of this study is to present an understanding of the experience of Brazilian homemakers with type 2 diabetes mellitus (DM2). A descriptive exploratory design was used and semi-structured interviews were conducted with 25 Brazilian homemakers concerning their experience. The interviews were recorded, transcribed, and the resulting text was analyzed using the sequential step method. Data converged to one dominant category, "constructing one's identity in the family context", which is...

  18. Myocardial glucose utilisation in type II diabetes mellitus patients treated with sulphonylurea drugs

    International Nuclear Information System (INIS)

    Yokoyama, Ikuo; Inoue, Yusuke; Moritan, Toshiyuki; Ohtomo, Kuni; Nagai, Ryozo

    2006-01-01

    Chronic sulphonylurea treatment maintains improved glycaemic control through mechanisms other than enhancement of insulin secretion and may act on various organs. The aim of this study was to investigate whether the chronic use of sulphonylurea drugs influences PET measurement of myocardial glucose utilisation (MGU) in type II diabetes mellitus. Forty-two patients with type II diabetes mellitus and 17 control subjects underwent dynamic 18 F-FDG PET to measure MGU during hyperinsulinaemic euglycaemic clamping. Twenty-one patients had been taking sulphonylurea drugs for more than 1 year (SU group), and the other 21 patients were drug naive (non-SU group). The haemoglobin A1c levels in the two patient groups were similar. Glucose disposal rate (GDR) was also determined as a marker of whole-body insulin resistance. GDR in the SU group (9.01±2.53 mg min -1 kg -1 ) was significantly higher than that in the non-SU group (4.10±2.47, p -1 100 g -1 ) was significantly higher than that in the non-SU group (5.53±2.05, p<0.01) and was similar to that in the controls (7.49±2.74). (orig.)

  19. The drama of the continuous increase in end-stage renal failure in patients with type II diabetes mellitus.

    Science.gov (United States)

    Rychlík, I; Miltenberger-Miltenyi, G; Ritz, E

    1998-01-01

    Type II diabetes mellitus has become the leading cause of end-stage renal failure in many countries of Western Europe. In all European countries, even in those with a relatively low prevalence of diabetic nephropathy, the number of patients with type II diabetes mellitus admitted for renal replacement therapy has recently increased continuously. Survival and medical rehabilitation of patients with type II diabetes on renal replacement therapy is significantly worse than in non-diabetic patients. It is obvious that in order to stem the tide, intense efforts are necessary (i) to inform the medical community about the renal risk of type II diabetes and the striking effectiveness of preventive measures, (ii) to provide better care for diabetic patients, and (iii) to reduce the high prevalence of diabetes in the population by modification of the Western life style.

  20. Factores de no adherencia al tratamiento en personas con Diabetes Mellitus tipo 2 en el domicilio. La visión del cuidador familiar Fatores de não aderência ao tratamento em pessoas com diabetes mellitus tipo 2 no domicílio. A visão do cuidador familiar Non adherence factors to treatment of people with type 2 Diabetes Mellitus at home. Family caregiver’s view

    Directory of Open Access Journals (Sweden)

    Teresa Nury Hoyos Duque

    2011-07-01

    Full Text Available Objetivo. Comprender los factores para no adherencia al trata- miento de personas con Diabetes Mellitus tipo 2 (DM2, desde la visión del cuidador familiar. Metodología. Estudio etnográfico enfocado. En 2008 se realizaron 18 entrevistas a cuidadores de pacientes con DM2, pertenecientes a programas de control de diabetes de instituciones de salud de Medellín (Colombia, y también se efectuaron seis observaciones de momentos significativos del cuidado. Resultados. La adherencia al tratamiento en personas con DM2 está mediada por múltiples factores que la dificultan como: concepciones culturales de la enfermedad, desencuentro entre los discursos del equipo profesional de salud y el saber popular, cansancio de tomar tantos medicamentos, miedo a la múltiples punciones por la aplicación de la insulina, insatisfacción con la calidad brindada de los servicios de salud y el costo económico de la enfermedad a largo plazo. Conclusión. Desde la visión de los cuidadores familiares, la adherencia al tratamiento de las personas con DM2 es escasa; hay múltiples factores que influyen en ello.Objetivo. Compreender os fatores para não aderência ao tratamento de pessoas com Diabetes Mellitus tipo 2 (DM2, desde a visão do cuidador familiar. Metodologia. Estudo etnográfico enfocado. Em 2008 se realizaram 18 entrevistas a cuidadores de pacientes com DM2, pertencentes a programas de controle de diabete de instituições de saúde de Medellín (Colômbia, e também se efetuaram seis observações de momentos significativos do cuidado. Resultados. A aderência ao tratamento em pessoas com DM2 está mediada por múltiplos fatores que a dificultam como: concepções culturais da doença, desencontro entre os discursos da equipe profissional de saúde e o saber popular, cansaço de tomar tantos medicamentos, medo à múltiplas punções pela aplicação da insulina, insatisfação com a qualidade brindada dos serviços de saúde e o custo econômico da doen

  1. Asociación entre el estado periapical y endodóncico y la diabetes Mellitus tipo II

    OpenAIRE

    Sánchez Domínguez, Benito

    2015-01-01

    INTRODUCCION Endodoncia y patología sistémica: medicina endodóncica Como resultado de la constatación científica de la relación existente entre la enfermedad periodontal y diferentes patologías sistémicas, recientemente el tema de la infección focal y la posible influencia de las infecciones endodóncicas sobre la salud general ha vuelto a resurgir una vez más con la publicación de trabajos de revisión científica (Hughes et al. 1994; Newman et al. 1996). Meinig, en su libro editado...

  2. Frecuencia de mutaciones en el gen de la usherina (USH2A) en 26 individuos colombianos con síndrome de Usher, tipo II

    OpenAIRE

    López, Greizy; Gelvez, Nancy Yaneth; Tamayo, Martalucía

    2011-01-01

    Introducción. El síndrome de Usher se caracteriza por hipoacusia neurosensorial congénita, retinitis pigmentaria y disfunción vestibular. Es la causa más frecuente de sordo-ceguera en el mundo. Se divide en tres tipos clínicos y doce subtipos genéticos. El tipo II es la forma más común y cerca de 80 % de los casos corresponden al subtipo 2 del síndrome de Usher. Objetivo. Establecer la frecuencia de mutaciones en la isoforma corta del gen USH2A en individuos colombianos con síndrome de Usher,...

  3. Frecuencia de mutaciones en el gen de la usherina (USH2A) en 26 individuos colombianos con síndrome de Usher, tipo II

    OpenAIRE

    Greizy López; Nancy Yaneth Gelvez; Martalucía Tamayo

    2011-01-01

    Introducción. El síndrome de Usher se caracteriza por hipoacusia neurosensorial congénita, retinitis pigmentaria y disfunción vestibular. Es la causa más frecuente de sordo-ceguera en el mundo. Se divide en tres tipos clínicos y doce subtipos genéticos. El tipo II es la forma más común y cerca de 80 % de los casos corresponden al subtipo 2 del síndrome de Usher. Objetivo. Establecer la frecuencia de mutaciones en la isoforma corta del gen USH2A en individuos colombianos con síndrome de Ush...

  4. Síndrome Poliglandular Autoinmune Tipo II: Posible Asociación con HLA DRB1*-DQB1* Possible association of Type II Autoimmune Polyendrocrine Syndrome with HLA DRB1*-DQB1*

    OpenAIRE

    M.S. Mallea Gil; M.C. Ballarino; M.M. Aparicio; K. Bertini; M.C. Ridruejo; S. Gimenez; P. Galarza; A. Perusco; S. Roveto; D. Rimoldi

    2010-01-01

    Los síndromes poliendocrinos autoinmunes (APS) asocian enfermedades endocrinas autoinmunes con otros desórdenes autoinmunes no endocrinos. El APS tipo II se caracteriza por compromiso primario suprarrenal, tiroideo y/o DM tipo I. Presentamos un paciente masculino de 46 años que fue internado por astenia, adinamia, hiporexia, severa disminución de peso, mareos y vómitos. Antecedente de obesidad y diabetes diagnosticada 3 años antes. Presentaba hipotensión arterial, hiperpigmentación de mucosas...

  5. Resultados de un seguimiento educativo a personas con diabetes mellitus tipo 2 y sobrepeso u obesidad Results of educational follow-up of persons with type 2 diabetes mellitus and overweight/obesity

    Directory of Open Access Journals (Sweden)

    Rosario García

    2003-12-01

    Full Text Available El presente trabajo muestra los resultados de un seguimiento educativo a personas con diabetes mellitus tipo 2 y sobrepeso corporal u obesidad, realizado como continuidad del estudio latinoamericano PEDNID-LA, con el objetivo de evaluar, en forma prospectiva, los cambios clínicos, bioquímicos y terapéuticos obtenidos después de participar en un programa de educación grupal con metodología interactiva. El estudio incluyó 40 pacientes no insulino dependientes, obesos o en sobrepeso y preferentemente de reciente inicio de la enfermedad, seleccionados en orden cronológico de asistencia a la consulta ambulatoria. Se estableció una consulta interactiva trimestral, donde cuidados y educación se desarrollaban como una unidad, y el contenido educativo iba surgiendo de las necesidades reales y sentidas del grupo, lo que se centró en promover la participación activa del paciente y aumentar la adhesión al tratamiento, con prioridad del plan de alimentación, la actividad física, la reducción del peso corporal y el automonitoreo de glucosa en orina, tal como se había hecho con otros grupos de personas con diabetes. Los conocimientos sobre diabetes se midieron en cuestionarios idénticos diseñados en el protocolo general multicéntrico del estudio PEDNID-LA y aplicados al inicio y final de dicho estudio y a los 4 años del seguimiento interactivo. El resto de las variables fueron valoradas antes, después del año del estudio PEDNID-LA y a los 4 años del seguimiento interactivo. Los datos fueron procesados mediante el uso del programa Epi-Info. Las diferencias estadísticas se determinaron por prueba de Chi cuadrado, y se aceptó p The present paper showed the results of educational follow-up of persons with type 2 diabetes mellitus and overweight/obesity carried out as part of the Latin American study PEDNID-LA, with the objective of prospectively evaluating the clinical, biological and therapeutic changes after their participation in a

  6. Effect of 17β-estradiol on plasma lipids and LDL oxidation in postmenopausal women with type II diabetes mellitus

    NARCIS (Netherlands)

    Brussaard, H.E.; Leuven, J.A.G.; Kluft, C.; Krans, H.M.J.; Duyvenvoorde, W. van; Buytenhek, R.; Laarse, A. van der; Princen, H.M.G.

    1997-01-01

    In type II diabetes mellitus the altered hormonal state after menopause may represent an additional cardiovascular risk factor. Estrogen replacement therapy (ERT) is associated with a decreased cardiovascular risk, at least in nondiabetic post-menopausal women. We studied the effect of ERT on plasma

  7. Human T-cell Lymphotropic Virus types I and II (HTLV-I/II in French Guiana: clinical and molecular epidemiology Os Vírus T-Linfotrópicos Humanos tipo I (HTLV-I e tipo II (HTLV-II na Guiana Francesa: epidemiologia clínica e molecular

    Directory of Open Access Journals (Sweden)

    Mirdad Kazanji

    2003-10-01

    Full Text Available We review here the epidemiological studies performed by our group on human retrovirus HTLV-I and HTLV-II infections and the associated diseases in French Guiana since 1984. French Guiana is an overseas French administrative district located between Brazil and Surinam. Its population is characterized by a large variety of ethnic groups, including several populations of African origin and various populations of Amerindian origin. Several epidemiological studies of large samples of pregnant women and in remote villages showed that HTLV-I is highly endemic in this area but is restricted to groups of African origin, especially the Noir-Marrons. In this endemic population, the results of segregation analysis in a genetic epidemiological study were consistent with the presence of a dominant major gene predisposing to HTLV-I infection, especially in children. In contrast, HTLV-II infection appears to be rare in French Guiana, having been found in only a few individuals of Brazilian origin. From a molecular point of view, the HTLV-I strains present in the Noir-Marrons, Creoles and Amerindians appear to originate from Africa, as they belong to the large cosmopolitan molecular subtype A.Os autores apresentam uma revisão dos estudos epidemiológicos realizados pelo seu grupo de pesquisa sobre a infecção pelos vírus T-linfotrópicos humanos tipo I (HTLV-I e tipo II (HTLV-II e doenças associadas na Guiana Francesa, desde 1984. A Guiana Francesa é um Departamento de Ultramar da França, situado entre o Brasil e o Suriname. A população é caracterizada por uma grande variedade de grupos étnicos, incluindo diversas comunidades de origem africana e outras de origem indígena. Diversos inquéritos epidemiológicos sobre gestantes e em aldeias remotas mostraram que o HTLV-I é altamente endêmico nessas áreas, mas que o vírus é restrito a grupos de origem africana, particularmente os Noir-Marrons. Nessa população endêmica, os resultados de uma an

  8. Diabetes Mellitus II: la importancia de las redes de apoyo como soporte al padecimiento (Diabetes Mellitus II: the importance of support networks to support the suffering

    Directory of Open Access Journals (Sweden)

    Guadalupe Cartas-Fuentevilla

    2011-07-01

    Full Text Available Objetivo. Comprender el papel de la formación de redes de apoyo familiares, institucionales y de amigos en las mujeres diabéticas que acuden al Centro de Salud y al Club de Diabéticos de San Cristóbal de Las Casas, Chiapas, en el proceso de salud-enfermedad-atención de la diabetes mellitus II. Metodología. Estudio cualitativo de corte etnográfico; los datos se obtuvieron a través de grupos focales y entrevistas a profundidad a partir del análisis de casos en cuatro mujeres diabéticas. Resultados. Las redes institucionales constituyen la principal estrategia de atención, control y búsqueda de alivio por parte de nuestras informantes. Las mujeres se autoperciben más valoradas en el Club que dentro de su grupo familiar debido a que se sienten identificadas y comprendidas por los demás enfermos generando un proceso identitario en torno a su condición de diabéticas. En los casos en que no se tiene el apoyo familiar requerido, ese vacío de solidaridad es cubierto por las amistades. Conclusiones. La red más fuerte y con mayor soporte es la institucional ya que a través de esta han aprendido a re-conocer su padecimiento, a resignificarlo mediante un proceso de transacción entre el discurso de la biomedicina y lo saberes de sentido común compartidos por otras y otros enfermos. La medicina institucional, a través del Centro de Salud y el Club de Diabéticos de San Cristóbal, ha logrado generar confianza y calidez en la relación médico-paciente favoreciendo la recuperación, control y alivio de su padecimiento.

  9. Correlación entre los niveles de Hemoglobina Glicada y las enzimas antioxidantes, en pacientes con Diabetes Mellitus Tipo 2

    OpenAIRE

    Vergaray, L.; Robles, Y.; Flores, E.; Suárez, S.

    2014-01-01

    It has been determined Glycated A1c haemoglobin, Superóxido Dismutase, Glutation peroxidase and Malondialdehide levels in 25 patients with Diabetes mellitus type 2, whom participate in the Education Program for Diabetic Patients, from Arzobispo Loayza Hospital, they were confront with 15 persons apparently healthful control group. There is a positive correlation between Glycated A1c haemoglobin - Superoxido Dismutase (r=0,164, p

  10. Parasitosis intestinales y factores de riesgo en niños: Ambulatorio urbano tipo II Dr. Agustín Zubillaga, Barquisimeto-Lara

    OpenAIRE

    Amaro C, Mariana I; Salcedo G, Darling J; Uris G, Marianny K; Valero B, Karen N; Vergara A, Mariany T; Cárdenas, Elsys; Vidal, Angel C; Sánchez Ch, Julia A

    2011-01-01

    Introducción: La posible asociación de las parasitosis intestinales con la pobreza y el saneamiento ambiental insuficiente, hacen necesario estudiar la prevalencia de este hecho en un barrio pobre de la ciudad de Barquisimeto, Venezuela. Objetivo: Determinar la frecuencia de parasitosis intestinales y factores de riesgo en niños de 1 a 12 años, de una zona pobre de Barquisimeto, Venezuela, área de influencia del Ambulatorio Urbano Tipo II “Dr. Agustín Zubillaga”. Método: Se realizó un estudio...

  11. Caso optométrico: exceso acomodativo tipo II inducido por estrés visual punto próximo

    OpenAIRE

    Gené Sampedro, Andrés; Hernández Andrés, Rosa María

    1996-01-01

    En este trabajo se trata de un caso clínico de exceso acomodativo que se sale de los signos tradicionales establecidos, denominándolo tipo II o espasmo acomodativo funcional. Esta alteración se produce habitualmente en época de exámenes, dándose cada vez con mayor asiduidad en consulta. Se describe el diagnóstico y el tratamiento para esta disfunción. Entre los signos que se salen de la norma está el ARP < ARN, las pupilas son normales. Como tratamiento se adaptaron lentes progresivas, junto ...

  12. Condições de saúde de pacientes com diabetes mellitus tipo 2 cadastrados na Estratégia Saúde da Família, em Ijuí, Rio Grande do Sul, 2010-2013

    Directory of Open Access Journals (Sweden)

    Eliane Roseli Winkelmann

    Full Text Available OBJETIVO: descrever as condições de saúde de pacientes com diabetes mellitus tipo 2 (DM2 com idade <75 anos, cadastrados na Estratégia Saúde da Família da área urbana do município de Ijuí-RS, Brasil, em 2010-2013. MÉTODOS: estudo descritivo de tipo série de casos; foram estudadas características sociodemográficas, condições de saúde, hábitos de vida e alimentares, complicações possivelmente associadas a DM2, antropometria, capacidade funcional, qualidade de vida e exames bioquímicos. RESULTADOS: dos 219 pacientes, 64,8% eram mulheres com idade média de 61,4 anos; hipertensão arterial (74,9% e alterações visuais (63,1% foram a comorbidade e a complicação mais prevalentes, respectivamente; antidiabéticos e antihipertensivos (69,9% foram os medicamentos mais prescritos; o desempenho na avaliação funcional e na qualidade de vida foi adequado, exceto na força expiratória; 36,5% dos homens e 56,8% das mulheres apresentavam triglicerídeos elevados; 40,0% das mulheres apresentavam glicose elevada. CONCLUSÃO: as prevalências de comorbidades e complicações associadas ao DM2 foram elevadas.

  13. Salivary flow rate and xerostomia in patients with type I and II diabetes mellitus.

    Science.gov (United States)

    Hoseini, Amineh; Mirzapour, Ali; Bijani, Ali; Shirzad, Atena

    2017-09-01

    Diabetes mellitus is one of the most prevalent metabolic diseases, with complications such as decreased salivary flow rate and xerostomia. This study aimed to determine the salivary flow rate and xerostomia in type I and II diabetic patients in comparison with healthy controls. This case-control study was performed on diabetic patients of a private office in Babol, Iran, between May 2015 and October 2016. This study involved two study groups (type I and II diabetes, with 40 in each group) and two control groups (control I and II, with 35 in each group) which were age- and sex-matched with the related study groups. They were all selected through simple sampling. Unstimulated whole saliva was collected through Navazesh method and the salivary flow rate was measured (ml/min). Xerostomia was evaluated via Fox's test. Moreover, the patients' data were recorded including age, sex, disease duration, type of diabetes, fasting blood glucose (FBG) and HbA1C. The obtained data were statistically analyzed by using SPSS version 17. Independent-samples t-test, Chi-square, Pearson correlation and multiple comparison post-hoc tests were employed as appropriated. psalivary flow rate in type I diabetics (0.35±0.11 ml/min) was lower than that in control I (0.50±0.07 ml/min) (p=0.01). The same difference was observed between type II diabetics (0.37±0.13 ml/min) and control II groups (0.47±0.11 ml/min) (p=0.01). No significant difference was observed in the salivary flow rate between type I and II diabetics (p=0.345). Furthermore, xerostomia was higher in type I (2.70±2.50, 1.17±1.60) and II (2.65±2.20-1.62±1.50) diabetics compared with the related control groups (p=0.01), (p=0.02). Type I, II diabetic patients revealed lower salivary flow rate and higher xerostomia compared with healthy controls. The salivary flow rate and xerostomia had inverse correlation.

  14. HABITS OF PATIENTS AND IMPORTANCE OF PHYSICAL EDUCATOR IN THE TREATMENT OF DIABETES MELLITUS TYPE II IN PALMAS, TOCANTINS, BRAZIL

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    Maynard Noleto SALES

    2015-12-01

    Full Text Available Diabetes mellitus, a non-communicable disease that can affect men and women, can be classified as type I or type II. This disease is in the 4th position in numbers of deaths in Brazil, and therefore, involves attention, both from the government, as the patients and family. The aims of this study is describe the lifestyle in relation to diet, foot care and proper medication, and the point of view of patients with diabetes mellitus type II, on the importance of the practice of physical exercise, coordinated and programmed. We performed a study using Questionnaire of Self-Care Activities with Diabetes (QAD and a second questionnaire with questions related to the importance of exercise for patients with diabetes mellitus type II. Questionnaires were applied in 20 patients with the disease (08 men and 12 women, living in the city of Palmas, Tocantins, Brazil. Result: We noticed that even with the recommendations of healthcare professionals, most patients with diabetes mellitus type 2 has not adapted verification of blood glucose, proper nutrition and foot care. Moreover, despite the interviewees know the importance of performing regular physical activity, we noticed that these do not know how much of weekly days in which they must get physical exercise in order to control the disease. Most interviewees adopt just walk as the physical activity, and we have not verified from the answers of patients, if they know what the most beneficial exercises to control this disease.

  15. The Intrauterine Device in Women with Diabetes Mellitus Type I and II: A Systematic Review.

    Science.gov (United States)

    Goldstuck, Norman D; Steyn, Petrus S

    2013-12-11

    Background. Women with diabetes mellitus type I and type II need effective contraception for personal and medical reasons. Long acting reversible contraceptive (LARC) methods are among the most efficient and cost-effective methods. Study Design. We searched the Popline, PubMed, and clinicaltrials.gov databases from 1961 to March 2013 for studies on the efficacy of the IUD in diabetic women and the possible changes it may produce in laboratory parameters. Studies of at least 30 subjects with DM1 or DM2 who were studied for 6 to 12 months depending on the method of analysis were eligible. Results. The search produced seven articles which gave event rate efficacy evaluable results and three which evaluated the effect of the IUD on laboratory parameters. One of the earlier efficacy studies showed an abnormally high pregnancy rate which sparked a controversy which is discussed in the Introduction section. The remaining 6 studies produced acceptable pregnancy rates. The three laboratory studies showed that the copper and levonorgestrel releasing IUD/IUS do not affect the diabetic state in any way. Conclusions. The copper bearing and levonorgestrel releasing IUDs are safe and effective in women with diabetes type I and diabetes type II although the evidence in the latter is limited.

  16. [Diabetic foot risk in patients with type II diabetes mellitus in a family medicine unit].

    Science.gov (United States)

    Márquez-Godínez, S A; Zonana-Nacach, A; Anzaldo-Campos, M C; Muñoz-Martínez, J A

    2014-01-01

    To determine the risk of diabetic foot in patients with type II diabetes mellitus (DM) seen in a Family Medicine Unit. The study included type II DM patients with a disease duration ≥ 5 years seen in a Family Medicine Unit, Tijuana, Mexico, during September-December 2011. Neuropathy was assessed with the Diabetic Neuropathy Symptom questionnaire, and pressure sensation using a 10-g Semmes-Weinstein monofilament. A patient had a high risk of diabetic foot if there was sensitivity loss, foot deformities, and non-palpable pedal pulses. We studied 205 patients with an average (± SD) age and DM duration of 59 ± 10 years and 10.7 ± 6.7 years, respectively. Ninety one patients (44%) had a high risk of developing diabetic foot, and it was associated with; an education of less than 6 years (OR 2.3; 95%CI: 1-1-4.1), DM disease duration ≥ 10 years (OR 5.1; 95%CI: 2.8-9.4), female gender (OR 2.0; 95%CI: 1.1-3.6), monthly familiar income diabetic neuropathy, since they have a high risk of diabetic foot. Copyright © 2013 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España. All rights reserved.

  17. Tratamento cirúrgico das fraturas do odontóide tipo II com parafuso anterior: análise de 15 casos

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    Dantas Fernando Luiz Rolemberg

    2002-01-01

    Full Text Available Apresentamos estudo retrospectivo dos resultados de 15 pacientes consecutivos, com fratura do odontóide tipo II P (fratura com traço oblíquo e deslocamento posterior e II N (fratura com traço horizontal na base do odontóide, segundo a classificação de Roy-Camille , que foram submetidos a fixação anterior direta do odontóide com parafuso. A série é composta por 13 homens e 2 mulheres, com idade variando entre 14 a 74 anos e período de acompanhamento de 6 a 36 meses (média 20 meses. Tivemos apenas uma complicação relacionada com a técnica cirúrgica: um parafuso mal posicionado necessitando de uma reoperação para ser reposicionado. Não houve óbito. Não houve saída nem quebra de parafuso. Obteve-se 94% de fusão óssea. Propomos que seja utilizada a classificação de Roy-Camille na seleção dos casos cirúrgicos de fraturas do odontóide, pois ela fornece uma abordagem cirúrgica específica para cada tipo de fratura.

  18. Insulin therapy refusal among type II diabetes mellitus patients in Kubang Pasu district, Kedah, Malaysia

    Science.gov (United States)

    Tan, Wei Leong; Asahar, Siti Fairus; Harun, Noor Liani

    2015-01-01

    INTRODUCTION Diabetes mellitus is a rising non-communicable disease in Malaysia. Insulin therapy refusal is a challenge for healthcare providers, as it results in delayed insulin initiation. This study was conducted to determine the prevalence of insulin therapy refusal and its associated factors. METHODS This cross-sectional study was conducted at seven public health clinics in Kubang Pasu district of Kedah, Malaysia, from March to October 2012. A newly developed and validated questionnaire was used and participants were selected via systematic random sampling. Only patients diagnosed with type II diabetes mellitus (T2DM) and under the public health clinic care in Kubang Pasu were included in the study. Multiple logistic regression was used to study the association between insulin therapy refusal and its associated factors. RESULTS There were 461 respondents and the response rate was 100%. Among these 461 patients with T2DM, 74.2% refused insulin therapy. The most common reason given for refusal was a lack of confidence in insulin injection (85.4%). Multiple logistic regression revealed that respondents who had secondary education were 55.0% less likely to refuse insulin therapy than those who had primary education or no formal education (adjusted odds ratio [OR] 0.45, 95% confidence interval [CI] 0.25–0.82, p = 0.009). There was also a significant inverse association between glycated haemoglobin (HbA1c) level and insulin therapy refusal (adjusted OR 0.87, 95% CI 0.76–1.00, p = 0.047). CONCLUSION Insulin therapy refusal is common in Kubang Pasu. Educational status and HbA1c level should be taken into consideration when counselling patients on insulin therapy initiation. PMID:25532511

  19. The burden of gestational diabetes mellitus in Jamaican women with a family history of autosomal dominant type 2 diabetes La carga de la diabetes mellitus gestacional en mujeres de Jamaica con antecedentes familiares de diabetes autosómica dominante tipo 2

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    Rachael R. Irving

    2008-02-01

    Full Text Available OBJECTIVES: To determine if Jamaican women of African descent with a family history of early onset autosomal dominant type 2 diabetes have greater odds of developing gestational diabetes mellitus (GDM than those without a family history of the disease. METHODS: A comparative study was conducted of two groups of pregnant Jamaican women: the first with a family history of early onset autosomal dominant type 2 diabetes; the second with no history of the disease. Incidence, odds for developing GDM, and metabolic profiles in first and second trimesters were assessed using SPSS 11.5 (SPSS Inc., Chicago, Illinois, United States. RESULTS: The incidence of GDM was 12.0 % in women with a family history of early onset autosomal dominant type 2 diabetes and 1.5% in women without a family history of the disease (P OBJETIVOS: Determinar si las mujeres jamaicanas de ascendencia africana con antecedentes familiares de inicio temprano de diabetes autosómica dominante tipo 2 tienen mayor probabilidad de desarrollar diabetes mellitus gestacional (DMG que las que no tienen esos antecedentes familiares. MÉTODOS: Se realizó un estudio comparativo con dos grupos de mujeres jamaicanas embarazadas: el primero con mujeres que tenían antecedentes familiares de inicio temprano de diabetes autosómica dominante tipo 2 y el segundo con mujeres sin antecedentes familiares de esa enfermedad. Se empleó el programa SPSS v. 11.5 (SPSS Inc., Chicago, Illinois, Estados Unidos de América para analizar los resultados y calcular la incidencia, la probabilidad de desarrollar DMG y los perfiles metabólicos en el primer y el segundo trimestres de gestación. RESULTADOS: La incidencia de DMG fue de 12,0% en las mujeres con antecedentes familiares de inicio temprano de diabetes autosómica dominante tipo 2 y de 1,5% en las mujeres sin antecedentes familiares de esa enfermedad (P < 0,05. Las mujeres del primer grupo tuvieron nueve veces más probabilidades de desarrollar DMG que las

  20. Differential impact of diabetes mellitus type II and arterial hypertension on collateral artery growth and concomitant macrophage accumulation.

    Science.gov (United States)

    Ito, Wulf D; Lund, Natalie; Sager, Hendrik; Becker, Wiebke; Wenzel, Ulrich

    2015-01-01

    Diabetes mellitus type II and arterial hypertension are major risk factors for peripheral arterial disease and have been considered to reduce collateral growth (arteriogenesis). Collateral growth proceeds through different stages. Vascular proliferation and macrophage accumulation are hallmarks of early collateral growth. We here compare the impact of arterial hypertension and diabetes mellitus type II on collateral proliferation (Brdu incorporation) and macrophage accumulation (ED 2 staining) as well as collateral vessel function (collateral conductance) in a rat model of peripheral vascular disease (femoral artery occlusion), diabetes mellitus type II (Zucker fatty diabetic rats and Zucker lean rat controls) and arterial hypertension (induced via clip placement around the right renal arteriy). We furthermore tested the impact of monocyte chemoattractant protein-1 (MCP‑1) on collateral proliferation and macrophage accumulation in these models Diabetic animals showed reduced vascular proliferation and macrophage accumulation, which however did not translate into a change of collateral conductance. Hypertensive animals on the contrary had reduced collateral conductances without altered macrophage accumulation and only a marginal reduction in collateral proliferation. Infusion of MCP‑1 only enhanced vascular proliferation in diabetic animals. These findings illustrate that impaired monocyte/macrophage recruitment is responsible for reduced collateral growth under diabetic conditions but not in arterial hypertension suggesting that diabetes mellitus in particular affects early stages of collateral growth whereas hypertension has its impact on later remodeling stages. Successful pro-arteriogenic treatment strategies in a patient population that presents with diabetes mellitus and arterial hypertension need to address different stages of collateral growth and thus different molecular and cellular targets simultaneously.

  1. Dyslipidemias in type II mellitus patients in a teaching hospital of Lahore, Pakistan

    International Nuclear Information System (INIS)

    Naheed, T.; Khan, A.; Masood, G.; Bilal-Bin-Yunus; Chaudhry, M.A.

    2003-01-01

    Subject: One hundred consecutive type II diabetics between the age of 40-70 years. Those who had hyperlipidemia due to other causes e.g. nephrotic syndrome, hypothyroidism and type-I diabetes mellitus were excluded. Results: One hundred patients suffering from type II diabetes were included in the study. Out of these 64% were females and 36% were males. The age range was 41-70 years with mean of 56.1 plus minus 9.38. Out of these 100 patients, duration of diabetes mellitus of less than 10 years was noted in 43% of patients and more than 10 years in 57%. Random blood sugar was 229.34 plus minus 6.23 and fasting blood sugar was 153.5 plus minus 4.45 when it was seen in the total study subjects, random blood sugar 210.51 plus minus 7.68 and fasting blood sugar 143.83 plus minus 5.35 in sub group whose duration of illness was less than 10 years. In sub group whose DM was more than 10 years random blood sugar was 257.91 plus minus 12.81 and fasting blood sugar was 171.21 plus minus 8.14. Serum cholesterol was 226.88 plus minus 18.48 in the patients as one group, in illness of less than 10 years, it was 191.72 plus minus 5.72 and in illness of more than 10 years duration it was 213.11 plus minus 6.70. Serum triglyceride in illness of less than 10 years duration was 191.83 plus minus 8.05 and where it was more than 10 years, it was 210.04 plus minus 8.90. Serum HDL-C was 36.25 plus minus 0.45 in patients illness of less than 10 years and 35.57 plus minus 0.60 in more than 10 years. Serum LDL - C was 127.1 plus minus 3.99 in patients with less than 10 years of diabetes mellitus and 147.5 plus minus 5.20 in patients with more than 10 years of illness. Fifty-eight patients were hypertensive, 43% of the male patients were smokers. Conclusions: Diabetic dyslipidemia in an important cause of morbidity. Duration of diabetes is associated with higher incidence of dyslipidemia. Type II DM is associated with marked increase in the risk of CHD. Dyslipidemia is believed to be a major

  2. Dyslipidemias in type II mellitus patients in a teaching hospital of Lahore, Pakistan

    Energy Technology Data Exchange (ETDEWEB)

    Naheed, T [King Edward Medical College, Lahore (Pakistan). Dept. of Medicine; Khan, A; Masood, G; Bilal-Bin-Yunus,; Chaudhry, M A [Fatima Jinnah Medical College, Lahore (Pakistan). Dept. of Medicine

    2003-12-01

    Subject: One hundred consecutive type II diabetics between the age of 40-70 years. Those who had hyperlipidemia due to other causes e.g. nephrotic syndrome, hypothyroidism and type-I diabetes mellitus were excluded. Results: One hundred patients suffering from type II diabetes were included in the study. Out of these 64% were females and 36% were males. The age range was 41-70 years with mean of 56.1 plus minus 9.38. Out of these 100 patients, duration of diabetes mellitus of less than 10 years was noted in 43% of patients and more than 10 years in 57%. Random blood sugar was 229.34 plus minus 6.23 and fasting blood sugar was 153.5 plus minus 4.45 when it was seen in the total study subjects, random blood sugar 210.51 plus minus 7.68 and fasting blood sugar 143.83 plus minus 5.35 in sub group whose duration of illness was less than 10 years. In sub group whose DM was more than 10 years random blood sugar was 257.91 plus minus 12.81 and fasting blood sugar was 171.21 plus minus 8.14. Serum cholesterol was 226.88 plus minus 18.48 in the patients as one group, in illness of less than 10 years, it was 191.72 plus minus 5.72 and in illness of more than 10 years duration it was 213.11 plus minus 6.70. Serum triglyceride in illness of less than 10 years duration was 191.83 plus minus 8.05 and where it was more than 10 years, it was 210.04 plus minus 8.90. Serum HDL-C was 36.25 plus minus 0.45 in patients illness of less than 10 years and 35.57 plus minus 0.60 in more than 10 years. Serum LDL - C was 127.1 plus minus 3.99 in patients with less than 10 years of diabetes mellitus and 147.5 plus minus 5.20 in patients with more than 10 years of illness. Fifty-eight patients were hypertensive, 43% of the male patients were smokers. Conclusions: Diabetic dyslipidemia in an important cause of morbidity. Duration of diabetes is associated with higher incidence of dyslipidemia. Type II DM is associated with marked increase in the risk of CHD. Dyslipidemia is believed to be a major

  3. Calcified carotid atherosclerotic plaques on digital panoramic radiographs in patients with Type II diabetes mellitus: A case control study

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    Neha Khambete

    2015-01-01

    Full Text Available Aim: Diabetes mellitus is associated with accelerated carotid artery atherosclerosis and increased risk of stroke. This study was conducted with the objective of determining the prevalence of calcified atherosclerotic plaques on panoramic radiographs of patients with Type II diabetes mellitus. Materials and Methods: Panoramic radiographs of 100 patients (age range 50-84 years with known history of type II diabetes mellitus, visiting the outpatient department were evaluated for the presence of calcified atherosclerotic plaques. Age- and sex-matched controls were evaluated in the same manner. Statistical comparison of prevalence rates was done. Results: The radiographs of diabetics (mean age: 64.45 years revealed that 26% had atheromatous plaques, whereas those of controls (mean age: 65.36 years revealed that 6% had atheromatous plaques. A statistically significant difference (P = 0.01410 was obtained using Yates′ Chi-square test. Conclusion: People with diabetes mellitus had a greater prevalence of calcified atherosclerotic plaques on panoramic radiographs than non-diabetics. Panoramic radiographs of diabetic patients should be screened for the presence of carotid artery atheromatous plaques for timely medical referral of asymptomatic patients and avoiding any further serious consequences like cerebrovascular accidents.

  4. A relação entre polifarmácia, complicações crônicas e depressão em portadores de Diabetes Mellitus Tipo 2 Relación entre polifarmacia, complicaciones crónicas y depresión en portadores de Diabetes Mellitus Tipo 2 The relationship between polipharmacy, chronic complications and depression in individuals with Type 2 Diabetes Mellitus

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    Alexandra Bulgarelli do Nascimento

    2010-03-01

    Full Text Available Os objetivos deste estudo foram: caracterizar a polifarmácia entre portadores de Diabetes Mellitus tipo2(DM2; e correlacionar polifarmácia e número de complicações do DM2 com indicadores de depressão (Inventário de Depressão de Beck[IDB] e cortisol urinário[CORT]. A amostra foi composta por 40 pacientes da Liga de Diabetes do HCFM-USP, avaliados quanto aos indicadores de depressão (CORT e IDB e quanto à prática de polifarmácia e número de complicações do DM2. Os resultados mostraram que os medicamentos utilizados foram: antidiabéticos orais, insulinas, anti-hipertensivos, diuréticos, anti-lipêmicos e trombolíticos. No grupo estudado, 75% fizeram uso diário de 5 a 8 medicamentos, e 12,5% de 8 medicamentos/dia ou mais; todos fizeram no mínimo 3 tomadas diárias, 60% tinham entre 1 e 3 complicações do DM2, e 22,5% tinham 3 ou mais. A correlação entre os indicadores de depressão(IDB e CORT, o número de medicamentos e o número de complicações do DM2 não foi estatisticamente significante. No entanto, houve correlação positiva entre CORT e número de tomadas diárias de medicamentos (Spearman,r=0.319, p=0.019.Fueron objetivos de este estudio: caracterizar a la polifarmacia entre portadores de Diabetes Mellitus tipo 2 (DM2 y correlacionar la polifarmacia y el número de complicaciones de la DM2 con indicadores de depresión (Inventario de Depresión de Beck [IDB] y cortisol urinario [CORT]. La muestra fue integrada por 40 pacientes de la Liga de Diabetes del HCFM-USP evaluados respecto de los indicadores de depresión (CORT e IDB y también en cuanto a la práctica de polifarmacia y número de complicaciones de la DM2. Los resultados mostraron que los medicamentos utilizados fueron: antidiabéticos orales, insulinas, antihipertensivos, diuréticos, antilipemiantes y trombolíticos. Dentro del grupo estudiado, 75% de los pacientes utilizaban diariamente entre 5 y 8 medicamentos, un 12,5% de la muestra hacía uso de 8

  5. Analysis of serum from type II diabetes mellitus and diabetic complication using surface-enhanced Raman spectra (SERS)

    Science.gov (United States)

    Han, H. W.; Yan, X. L.; Dong, R. X.; Ban, G.; Li, K.

    2009-03-01

    In this paper, we show surface-enhanced Raman spectra (SERS) of serums from type II diabetes mellitus and diabetic complication (coronary disease, glaucoma and cerebral infarction), and analyze the SERS through the multivariate statistical methods of principal component analysis (PCA). In particular, we find that there exist many adenines in these serums, which maybe come from DNA (RNA) damage. The relative intensity of the band at 725±2 cm-1 assigned to adenine is higher for patients than for the healthy volunteers; therefore, it can be used as an important ‘fingerprint’ in order to diagnose these diseases. It is also shown that serums from type II diabetes mellitus group, diabetic complication group and healthy volunteers group can be discriminated by PCA.

  6. Relación entre características antropométricas y variables de riesgo vascular en diabéticos tipo 2 Relationship between anthropometric characteristics and its repercussion in Type-2 Diabetes Mellitus

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    Karelia Zubizarreta Peinado

    2012-06-01

    Full Text Available La interrelación existente entre obesidad y diabetes mellitus tipo 2 tiene gran importancia clínico-epidemiológica. Se propone como objetivo evaluar en diabéticos tipo 2 la relación entre las características antropométricas y el nivel de riesgo de variables clínicas y bioquímicas. Se estudiaron 120 pacientes, edades 40 a 79 años, de la consulta de diabetes del Hospital "Hermanos Ameijeiras¨, entre octubre del 2009 y septiembre del 2010. Se evaluaron antecedentes, complementarios, y se realizó examen clínico general. Se determinaron índice de masa corporal (IMC, circunferencia abdominal (CA, tensión arterial (TA, parámetros glucémicos (glucemia en ayunas, postprandial, hemoglobina glucosilada, lípidicos (colesterol, triglicéridos, HDL-C, LDL-C, así como ácido úrico y microalbuminuria y se clasificaron según riesgo vascular en bajo, moderado y alto. Se consideró alto riesgo la obesidad (IMC = de 30 kg/m²sc y CA aumentada (CAA hombres >102 cm y mujeres > 88 y se relacionaron con el nivel de riesgo predeterminado para el resto de las variables. Los resultados se analizaron estadísticamente con significación de p The interrelation between obesity and type-2 diabetes mellitus is very important from the clinical and epidemiological view points. This study was aimed at assessing the association between vascular risk and anthropometric variables in patients with type-2 diabetes mellitus, where the body-mass index and the abdominal size were evaluated in relation to the presence of chronic vascular complications in these patients. One hundred twenty (120 patients from 40 to 79 years old, attending to the diabetes mellitus office at “Hermanos Ameijeiras” University Hospital from October 2009 to September 2010 were included in the study considering the medical history, complementary and general clinical examinations. Body-mass index, abdominal size (AS, insulinemia and C-peptide were also determined; (IMC ≥ de 30 kg/m2 sc

  7. Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus

    DEFF Research Database (Denmark)

    Ek, J; Andersen, G; Urhammer, S A

    2001-01-01

    This study aimed to investigate if variability in the peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene is associated with Type II (non-insulin-dependent) diabetes mellitus.......This study aimed to investigate if variability in the peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene is associated with Type II (non-insulin-dependent) diabetes mellitus....

  8. Prevalence of eating disorders and psychiatric comorbidity in a clinical sample of type 2 diabetes mellitus patients Prevalência de transtornos alimentares e comorbidade psiquiátrica em uma amostra clínica de pacientes com diabetes mellitus do tipo 2

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    Marcelo Papelbaum

    2005-06-01

    Full Text Available BACKGROUND: A few studies have shown high rates of eating disorders and psychiatric morbidity in patients with type 2 diabetes mellitus. OBJECTIVE: disturbed eating behavior and psychiatric comorbidity in a sample of T2DM patients. METHODS: Seventy type 2 diabetes mellitus patients between 40 and 65 years of age (mean, 52.9 ± 6.8 from a diabetes outpatient clinic were sequentially evaluated. The Structured Clinical Interview for DSM-IV, Binge Eating Scale and Beck Depression Inventory were used to assess eating disorders and other psychiatric comorbidity. In addition to the descriptive analysis of the data, we compared groups divided based on the presence of obesity (evaluated by the body mass index or an eating disorder. RESULTS: Twenty percent of the sample displayed an eating disorder. Binge eating disorder was the predominant eating disorder diagnosis (10%. Overall, the group of obese patients with type 2 diabetes mellitus presented rates of psychiatric comorbidity comparable to those seen in their nonobese counterparts. However, the presence of an eating disorder was associated with a significant increase in the frequency of anxiety disorders (57.1% x 28.6%; p = 0.044. CONCLUSIONS: In our study sample, the occurrence of eating disorders was increased compared to rates observed in the general population, with the predominance of binge eating disorder. The presence of an eating disorder in type 2 diabetes mellitus patients was associated with higher rates of anxiety disorders.INTRODUÇÃO: Alguns estudos têm demonstrado uma freqüência elevada de transtornos alimentares (TA e morbidade psiquiátrica em pacientes com diabetes mellitus do tipo 2 (DM2. OBJETIVOS: Investigar a presença de alterações do comportamento alimentar e comorbidade psiquiátrica em uma amostra de pacientes com diabetes mellitus do tipo 2. MÉTODOS: Setenta pacientes com diabetes mellitus do tipo 2, com idade entre 40 e 65 anos (média de 52,9 ± 6,8, em tratamento

  9. Variantes polimórficas Ala513Pro y Gly972Arg del gen IRS-1 no se asocian a la diabetes mellitus tipo 2 en un grupo de la población cubana The Ala513Pro and Gly972ARg polymorphous variants of IRS-1 gen are not associated with type diabetes mellitus in a group of the Cuban population

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    Luis Miguel Pérez

    2011-08-01

    Full Text Available Introducción: la diabetes mellitus tipo 2 es una enfermedad heterogénea y multifactorial, que está determinada por factores genéticos y no genéticos. El sustrato 1 del receptor de la insulina (IRS-1 cumple una función fundamental en la transmisión de la señal insulínica, por tanto sus variantes génicas constituyen blancos importantes en el estudio de la susceptibilidad genética a esta enfermedad en las diferentes poblaciones. Objetivo: explorar el papel de las variantes polimórficas Gly972Arg y Ala513Pro del gen IRS-1 en la susceptibilidad genética de la diabetes mellitus tipo 2 en un grupo de la población cubana. Métodos: se determinó la frecuencia de los polimorfismos Gly972Arg y Ala513Pro del IRS-1 en 499 ciudadanos cubanos, con un índice de masa corporal entre 22-30, con edades comprendidas entre los 40 y 70 años: de ellos 272 (54,5 % diabéticos y 227 (45,5 % no diabéticos. Resultados: la frecuencia del alelo Pro513 fue baja (1,2 % y similar para ambos grupos (1,1 % vs. 1,3 % para el grupo de diabéticos y el grupo control, respectivamente. La frecuencia del polimorfismo Gly972Arg fue de 16,2%, superior a la reportada para la mayoría de las poblaciones estudiadas. No se encontraron diferencias significativas en la frecuencia del alelo Arg972 entre el grupo de diabéticos y el grupo control (15,4 % vs. 17,3 %, ni cambios en los niveles de glucemia e insulinemia asociados a la presencia del alelo polimórfico Arg972. Conclusiones: en este grupo de sujetos de la población cubana, las variantes polimórficas Ala513Pro y Gly972Arg del gen IRS-1 no participan en la etiología de la diabetes mellitus tipo 2.Introduction: the type 2 diabetes mellitus is a heterogeneous and multifactor disease determined by genetic and no-genetic factors. The substrate 1 of insulin receptor (IRS-1 has a fundamental function in transmission of insulin signal, thus its genic variants are significant targets in study of genetic susceptibility to

  10. Epigenetics and type II diabetes mellitus: underlying mechanisms of prenatal predisposition

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    J. David Sterns

    2014-05-01

    Full Text Available Type II diabetes mellitus (T2DM is a widespread metabolic disorder characterized by insulin resistance resulting in abnormally high blood glucose levels. While the onset of T2DM is known to be influenced by a number of genetic factors, emerging research has demonstrated the additional role of a variety of epigenetic mechanisms in the development of this disorder. Epigenetics relates to the heritable changes in gene expression that cannot be explained by simple variations in the primary DNA sequence and includes DNA methylation and histone modification. These changes impact many processes, including stem cell differentiation into pancreatic endocrine cells as well as normal β-cell function. Recent studies focusing on the effects of maternal health, specifically as it is affected by famine and hyperglycemia, have found possible mechanisms to explain the increased likelihood of the fetus developing risk factors such as altered atherogenic lipid profiles, increased obesity and BMI, as well as impaired glucose tolerance (IGT for the development of T2DM later in life. It is suggested that these epigenetic influences happen early during gestation and are less susceptible to the effects of postnatal environmental modification as was previously thought. Regardless, emerging research into epigenetic-based treatment approaches for T2DM are promising and offer yet another means by which to limit the impact of this global epidemic.

  11. Prognostic interaction patterns in diabetes mellitus II: A random-matrix-theory relation

    Science.gov (United States)

    Rai, Aparna; Pawar, Amit Kumar; Jalan, Sarika

    2015-08-01

    We analyze protein-protein interactions in diabetes mellitus II and its normal counterpart under the combined framework of random matrix theory and network biology. This disease is the fifth-leading cause of death in high-income countries and an epidemic in developing countries, affecting around 8 % of the total adult population in the world. Treatment at the advanced stage is difficult and challenging, making early detection a high priority in the cure of the disease. Our investigation reveals specific structural patterns important for the occurrence of the disease. In addition to the structural parameters, the spectral properties reveal the top contributing nodes from localized eigenvectors, which turn out to be significant for the occurrence of the disease. Our analysis is time-efficient and cost-effective, bringing a new horizon in the field of medicine by highlighting major pathways involved in the disease. The analysis provides a direction for the development of novel drugs and therapies in curing the disease by targeting specific interaction patterns instead of a single protein.

  12. Prevalence of type-II diabetes mellitus and diabetic retinopathy: the gaddap study

    International Nuclear Information System (INIS)

    Mahar, P.S.; Awan, Z.; Manzar, N.; Memon, S.

    2010-01-01

    To determine the frequency of type-II Diabetes mellitus (DM) in the endogenous population of Gaddap town and also to evaluate the status of Diabetic retinopathy (DR) in this group. This community based study of subjects of either gender was carried out in the Gaddap town. Three primary eye care centres were established in the existing primary health care (PHC) facilities, to screen the target Population aged 30 years and above, and who met other inclusion criteria for DM and DR respectively. Patients requiring intervention were managed accordingly. Data was entered and analyzed using Microsoft Visual Basic 6 and Microsoft Access. Out of the cohort of 19211 subjects, 1677 patients were found Diabetic, giving the prevalence of DM in Gaddap town at 8.73%, with 1258 (6.55%) known and 419 (2.18%) newly diagnosed cases. DR was seen in 460 (27.43%) of the Diabetic cases with 126 (7.51%) patients requiring urgent intervention for vision threatening complications. The result validates the importance of early screening of DR in people suffering from DM for possible management and prevention of sight threatening complications in the early stage of the disease and advocates the inclusion of primary eye care as a part of PHC system. (author)

  13. Detection of cerebral atrophy in type- II diabetes mellitus by magnetic resonance imaging of brain

    International Nuclear Information System (INIS)

    Khan, G.; Khan, N.; Aziz, A.

    2010-01-01

    Background: Diabetes is a metabolic disorder that affects many systems in the body. Cerebral atrophy is one of the complications of diabetes and research is on going to find out its aetiopathological factors. The main aim of the study was to determine the frequency of cerebral atrophy in type-II diabetes mellitus using magnetic resonance imaging of the brain. Methods: One hundred diabetic patients (Random blood sugar >126 mg/dl) were recruited in this study after the informed consent from every patient. Duration of diabetes was five years and more in all the patients as determined by their glycosylated haemoglobin which was >6 in all the patients. All the patients were undergone MRI of brain using 1.5 Tesla power magnetic resonance imaging machine of Picker Company. Evan's index, a specific parameter for measurement of cerebral atrophy was calculated on MR images and was used in this study. Results: In male group the frequency of cerebral atrophy was 22 (47%) and in female group it was found to be 23 (43%). When we study the overall population the frequency was found to be 45 (45%). The results are well in concordance with the previous data published on this issue. Conclusions: Cerebral atrophy, a complication of long standing diabetes is quite frequent in our population and is well diagnosed by MRI. (author)

  14. The detection of serum homocysteine (Hcy) level in II diabetes mellitus with hyperinsulinism

    International Nuclear Information System (INIS)

    He Meiqiong; Zhang Ling; Quan Xinsheng; Zhou Youjun; Wang Ying

    2003-01-01

    To explore the relationship between serum total homocysteine (Hcy) level and II diabetes mellitus (DM) with hyperinsulinism and insulin resistance, serum total Hcy level in 30 normal subjects and 78 type II DM (38 with hyperinsulinism) are detected. The results show: the mean serum Hcy level is 11.90 ± 3.90 μmo/L, 9.21 ± 2.83 μmol/L at oral glucose tolerance test (OGTT) 1 h and 10.43 ± 3.82 μmol/L at OGTT 2h in normal subjects (n=30); 21.80 ± 7.98 μmol/L, 17.98 ± 6.83 μmol/L at OGTT 1 h and 12.58 ± 6.73 μmol/L at OGTT 2 h in DM without hyperinsulinism and angiopathy (n=40); and 19.80 ± 7.98 μmol/L, 14.50 ± 7.69 μmol/L at OGTT 1 h and 11.07 ± 6.52 μmol/L at OGTT 2 h in DM with hyperinsulinism (n=38). The Hcy level is a significant difference among three groups (P<0.001, P<0.01). Hcy level of DM with hyperinsulinism is lower than that of DM with hyperinsulinism (P<0.01). The serum Hcy level in DM is higher than that in control group, the elevated level of serum Hcy may be related to the diabetic hyperinsulinism and insulin resistance

  15. Salivary glucose as a diagnostic tool in Type II diabetes mellitus: A ...

    African Journals Online (AJOL)

    Background and Objectives: The prevalence of diabetes mellitus is increasing steadily in India. Understanding blood glucose level is the key to both diagnosis and management of diabetes mellitus. However, there is an on‑going need for improvements in noninvasive, point‑of‑care tools for the diagnosis and prognosis of ...

  16. Las primeras producciones de antenas de la meseta. Patrones de influencia y desarrollo morfológico de las espadas de tipo Echauri/Quesada II

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    García Jiménez, Gustavo

    2006-12-01

    Full Text Available

    In this article the antennae sword type Echauri/Quesada II will be analysed starting from a detailed and compared revision of some known pieces. Their morfotecnical study and incorporation of unedited examples or examples that have not been studied in depth, will give us some clues about its relationship of origin with the aquitaine focal point and will enable us to distinguish four differentiated groups within this type. Attention will be paid to the form of the blades, antennae, guards and decorative elements, however it will be the long whole scabbard of these swords that will carry the fundamental weight of the classification.



    En este artículo se analizan las espadas de antenas de tipo Echauri/Quesada II a partir de la revisión detallada y comparada de algunas piezas conocidas. Su estudio morfotécnico y la incorporación de ejemplares inéditos o poco estudiados nos dará pistas sobre su relación de procedencia con el foco aquitano y nos permitirá distinguir cuatro grupos diferenciados dentro del tipo. Se prestará atención a la forma de las hojas, antenas, guardas y elementos decorativos, pero será la vaina enteriza de estas espadas la que llevará el peso fundamental de la clasificación.

  17. Acurácia das intervenções de enfermagem para pacientes com diabetes mellitus tipo 2 em consulta ambulatorial

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    Suzana Fiore Scain

    Full Text Available O objetivo do trabalho foi identificar a acurácia das intervenções de enfermagem a partir dos diagnósticos de enfermagem (DE de pacientes que consultaram no Programa de Educação em Diabetes, em ambulatório de hospital universitário, relacionando-os com as características sociodemográficas e as comorbidades. Trata-se de um estudo transversal de 136 pacientes com DM tipo 2 (DM2, sendo 77 (57% mulheres, com média de idade de 66±9,38 anos, presença de comorbidades em 97 (71% e em uso de medicações. Foi encontrada associação significativa entre os DE e as intervenções mais frequentemente prescritas: "Aconselhamento nutricional" (n = 99; 73%, "Promoção do exercício" (n = 64; 47% e "Ensino: cuidados com os pés" (n = 48; 35%, porém, não com as características sociodemográficas ou comorbidades. As intervenções de maior ocorrência prescritas em consulta de enfermagem evidenciaram acurácia para os DE nos domínios Promoção da Saúde e Nutrição, que estão relacionados aos princípios do tratamento para DM2: alimentação saudável, exercício físico e educação para a saúde.

  18. Prevalencia y factores DE RIESGO relacionados con la cetosis clínica y subclínica tipo I y II en un hato de vacas Jersey en Costa Rica

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    Alejandro Saborío-Montero

    2013-01-01

    Full Text Available El objetivo de este estudio fue analizar la prevalencia y grado de cetosis tipo I y tipo II e investigar los factores de riesgo asociados con esta enfermedad metabólica, en un hato Jersey de 203 vacas en Oreamuno, Cartago, Costa Rica (9° 55' Latitud Norte, 83° 51' Longitud Oeste, 2350 m de altitud, para proponer prácticas de manejo y alimentación que contribuyan a reducir la incidencia de este desbalance metabólico. La prevalencia de cetosis tipo II y tipo I fue determinada midiendo la concentración sanguínea del ácido β-hidroxibutírico (βHBA a los 8±3 y 30±3 días de lactancia en 117 y 114 animales, respectivamente. La cetosis clínica tipo II no fue detectada y 4,27% de las vacas tuvieron cetosis subclínica (1,4 a 2,9 mmol.l-1 de este tipo. Los porcentajes de vacas con cetosis clínica (>2,9 mmol.l-1 y subclínica tipo I fueron 3,51 y 9,65 respectivamente. Durante la última semana de gestación, la pérdida de condición corporal difirió (p<0,05 para vacas sanas y cetóticas tipo I y fue de 0,09 y 0,31 puntos, respectivamente. Las vacas con cetosis tipo I fueron de mayor (p<0,01 número de partos, duración del período seco más extensa (p<0,05 y mayor pico de lactancia (p<0,01, que las vacas sanas. Los resultados sugieren que calificar la condición corporal durante la última semana de gestación podría ser útil para predecir el riesgo de los animales a desarrollar cetosis tipo I. Basados en estos resultados, el manejo para evitar periodos secos mayores de 60 días ayudaría a reducir la incidencia de cetosis. Además, la alimentación y manejo de las vacas multíparas y vacas de mayor producción, conducente a reducir la pérdida de condición corporal post parto, también podrían reducir la incidencia de los diferentes tipos de cetosis.

  19. Soroprevalência da doença celíaca em crianças e adolescentes com diabetes melito tipo 1 Serum prevalence of celiac disease in children and adolescents with type 1 diabetes mellitus

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    Jacqueline Araújo

    2006-06-01

    Full Text Available OBJETIVO: A associação de doença celíaca e diabetes melito já é conhecida há várias décadas. Pode ser encontrada em uma grande proporção de pacientes diabéticos, que geralmente são assintomáticos. O objetivo do estudo foi avaliar a soroprevalência da doença celíaca em crianças e adolescentes com diabetes melito tipo 1. MÉTODOS: Através de um estudo transversal, realizou-se triagem sorológica com anticorpo IgA antitransglutaminase humana em 354 crianças e adolescentes diabéticos, atendidos em ambulatórios de endocrinologia pediátrica de Recife, Pernambuco, no período de janeiro a junho de 2004. RESULTADOS: O antitransglutaminase humana foi positivo em 37/354 pacientes, resultando em soroprevalência de 10,5% (IC95% 7,6-14,2%. Dentre os pacientes soropositivos, houve predomínio do sexo masculino (56,8% em relação ao feminino (43,2%, porém sem significância estatística. O anticorpo antiendomísio foi realizado nos pacientes com antitransglutaminase humana positivo, sendo negativo em 14/37 (37,8% e positivo em 22/37 (59,5%. CONCLUSÕES: A soroprevalência da doença celíaca em crianças e adolescentes diabéticos encontrada em Pernambuco é elevada, sendo comparável à observada em estudos da América do Norte e Europa e menor do que na África, sugerindo que a triagem sorológica para doença celíaca seja realizada em todas as crianças e adolescentes com diabetes melito tipo 1.OBJECTIVE: The association between celiac disease and diabetes mellitus has been known for many decades. This combination can be observed in a large proportion of diabetic patients, who are generally asymptomatic. The objective of this study was to evaluate the seroprevalence of celiac disease in children and adolescents with type 1 diabetes mellitus. METHODS: This was a cross-sectional study employing antibody IgA anti-transglutaminase for the serological screening of 354 diabetic children and adolescents treated at pediatric endocrinology

  20. A influência do turno de trabalho em pacientes com diabetes mellitus tipo 2 The influence of the work shift in patients with type 2 diabetes

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    Ticiana C. Rodrigues

    2008-04-01

    Full Text Available OBJETIVOS: O objetivo deste estudo foi investigar a relação entre trabalho em turnos e pacientes diabéticos tipo 2. MÉTODOS: Um estudo transversal foi realizado em uma coorte de 95 pacientes diabéticos que trabalham no Hospital de Clínicas de Porto Alegre. Os pacientes foram divididos em dois grupos de acordo com o turno de trabalho noturno e diurno. Os pacientes foram submetidos à avaliação clínica e laboratorial. RESULTADOS: Não houve diferença significativa em relação à idade, sexo, duração do diabetes, índice de massa corporal, glicemia de jejum, teste A1c, triglicerídeos, colesterol total, LDL colesterol, HDL colesterol, creatinina sérica e ácido úrico. Maior média de circunferência abdominal foi encontrada no grupo de trabalhadores noturnos. CONCLUSÃO: A circunferência abdominal foi mais elevada no grupo de trabalhadores noturnos. Isto pode ser um indicativo de maior resistência insulínica neste grupo de pacientes. Nossa pesquisa indica que o trabalho em turnos não esta associado com piora no controle metabólico em indivíduos diabéticos, nem com a presença de nefropatia diabética.OBJECTIVE: This study aimed to investigate the relationship between the work shift and diabetic patients. METHODS: A cross-section study was performed in a cohort of 95 type 2 diabetic patients that work in the Hospital de Clinicas de Porto Alegre. Patients were divided into 2 groups according to the shift, day or night work. Patients underwent clinical and laboratory evaluations. RESULTS: There were no significant differences in age, gender, diabetes duration, body mass index, blood pressure, fasting glucose, A1c (1%, triglycerides, total cholesterol, LDL cholesterol, HDL cholesterol, serum creatinine and uric acid. A higher average of waist circumference was found in the group of night workers. CONCLUSION: Waist circumference was greater in the group of night workers; which may be indicative of insulin resistance in this group

  1. Costos económicos en el tratamiento farmacológico del paciente con diabetes mellitus tipo 2. Estudio de pacientes en consulta externa de medicina interna de un hospital de segundo nivel de la Ciudad de México

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    Juan Pablo Ramírez-Hinojosa

    2017-01-01

    Full Text Available La diabetes mellitus tipo 2 (DM2 es considerada un problema de salud pública global. Es la primera causa de morbilidad-mortalidad en el país. Representa una enfermedad de alto costo para los sistemas de salud, con un gasto de 370 billones de dólares al año, que se estima alcanzará los 490 billones de dólares para 2030...

  2. Diabetes Mellitus II: la importancia de las redes de apoyo como soporte al padecimiento

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    Guadalupe Cartas-Fuentevilla

    2011-01-01

    Full Text Available Objetivo. Comprender el papel de la formación de redes de apoyo familiares, institucionales y de amigos en las mujeres diabéticas que acuden al Centro de Salud y al Club de Diabéticos de San Cristóbal de LasCasas, Chiapas, en el proceso de salud-enfermedad-atención de la Diabetes mellitus II. Metodología. Estudio cualitativo de corte etnográfico; los datos se obtuvieron a través de un grupo focal y entrevistas a profundidad a partir del análisis de casos en cuatro mujeres diabéticas. Resultados. Las redes institucionales constituyen la principal estrategia de atención, control y búsqueda de alivio por parte de nuestras informantes. Las mujeres se autoperciben más valoradas en el Club, que dentro de su grupo familiar debido a que se sienten identificadas y comprendidas por los demás enfermos generando un proceso identitario en torno a su condición de diabéticas. En los casos en que no se tiene el apoyo familiar requerido, ese vacío de solidaridad es cubierto por las amistades. Conclusiones. La red más fuerte y con mayor soporte es la institucional ya que a través de esta han aprendido a re-conocer su padecimiento, a resignificarlo mediante un proceso de transacción entre el discurso de la biomedicina y lo saberes de sentido común compartidos por otras y otros enfermos. La medicina institucional, a través del Centro de Salud y el Club de Diabéticos de San Cristóbal, ha logrado generar confianza y calidez en la relación médico-paciente favoreciendo la recuperación, control y alivio de su padecimiento.

  3. Los niños del Cauca. I. Descripción de un foco de raquitismo dependiente de la vitamina D, Tipo II.

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    Alejandro Giraldo

    1993-09-01

    Full Text Available Al norte del departamento del Cauca se detectó un numeroso grupo de pacientes con deformidades en miembros inferiores (genu varo, genu valgo o ambos que correspondían clínica y radiológicamente a un cuadro de raquitismo. Ninguno de los pacientes presentaban alopecia, miopatia, tetania o aminoaciduria. La mayoría deellos proceden de un grupo poblacional semiaislado de ancestro afromestizo, en el corregimiento de La Toma, del municipio de Suárez. Los estudios bioquímicos comparativos entre 64 pacientes y 109 individuos no afectados, parientes en primer grado, mostraron en los pacientes una ligera hipocalcemia, niveles normales altos de fósforo sérico, un sustancial incremento de la fosfatasa alcalina,valores normales de proteínas y albúminas y niveles séricos de paratohormona aumentados. Estudios en orina de 24 horas mostraron hipocalciuria e hipofosfaturia. A un subgrupo de 8 pacientes se les determino niveles séricos de la 25 (OHD, y ltipo de raquitismo pertenecían nuestros pacientes. Se observó un marcado incremento de lcr, 25(OH,A3, por lo que esta patología corresponde al raquitismo dependiente de la vitamina D, tipo II. Se trata de un tipo de raquitismo genético transmitido en forma autocómica recesiva, cuyas manifestaciones clínicas y de laboratorio se presentan por un defecto en la acción del receptor para la vitamina D. A 115 pacientes se les inició tratamiento con 1a,25(OH,A3 hig 0,50/día, calcio 1.840 mg/día y fósforo 1.424 mg/día, administrados en dos dosis diarias. En un grupo de 21 pacientes, se analizaron los datos de laboratorio en suero, pre y posttratamiento un ano después y todos los valores tendieron a normalizarse. Estudios moleculares, del mRNA y cDNA del gen del receptor de la vitamina D, obtenidos de cultivo de fibroblastos de dos de los pacientes más severamente afectados, mostraron una secuencia normal de nucleótidos. Se hace una comparación entre los

  4. Asociación de la neuropatía autonómica cardiovascular y el intervalo QT prolongado con la morbimortalidad cardiovascular en pacientes con diabetes mellitus tipo 2 Association of cardiovascular autonomic neuropathy and prolonged QT interval with cardiovascular morbidity and mortality in patients with type 2 diabetes mellitus

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    Ray Ticse Aguirre

    2011-03-01

    Full Text Available Con el objetivo de evaluar la relación entre la neuropatía autonómica cardiovascular (NACV y el intervalo QT corregido (QTc con la morbimortalidad cardiovascular en pacientes con diabetes mellitus tipo 2, se realizó el seguimiento a 5 años de 67 pacientes que acudieron a consulta externa del Servicio de Endocrinología. Se presentaron eventos cardiovasculares en 16 pacientes; el 82% completó el seguimiento y se encontró que el intervalo QTc prolongado fue la única variable que se asoció de forma significativa a morbimortalidad cardiovascular en el análisis de regresión logística múltiple (RR: 13,56; IC 95%: 2,01-91,36 (p=0,0074.In order to evaluate the relationship between cardiovascular autonomic neuropathy and corrected QT interval (QTc with cardiovascular morbidity and mortality in patients with type 2 diabetes mellitus, we followed up for 5 years 67 patients attending the outpatient Endocrinology Service. 82% completed follow-up and cardiovascular events occurred in 16 patients. We found that long QTc interval was the only variable significantly associated with cardiovascular morbidity and mortality in the multiple logistic regression analysis (RR: 13.56, 95% CI: 2.01-91.36 (p = 0.0074.

  5. Estudo caso-controle sobre exposição precoce ao leite de vaca e ocorrência de Diabetes Mellitus tipo 1 em Campina Grande, Paraíba Case-control study on early exposure to cow's milk and the occurrence of Diabetes Mellitus type 1 in Campina Grande in the State of Paraíba

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    Josimar dos Santos Medeiros

    2003-09-01

    Full Text Available OBJETIVOS: estudar a relação entre exposição precoce ao leite de vaca e ocorrência de Diabetes Mellitus tipo 1 entre menores de 18 anos atendidos no Hospital Universitário Alcides Carneiro, em Campina Grande. MÉTODOS: estudo caso-controle. A amostra foi constituída por 128 indivíduos de ambos os sexos. Foram entrevistadas 64 mães de portadores de Diabetes Mellitus e 64 mães de controles. Análises univariadas e multivariadas foram utilizadas. RESULTADOS: 84,4% dos indivíduos diabéticos foram expostos ao leite de vaca antes dos quatro meses de idade, enquanto que no grupo controle este percentual foi de 64,1%. A análise univariada identificou uma associação estatisticamente significante entre exposição precoce ao leite de vaca e Diabetes (p = 0,01. Na análise multivariada, essa associação permaneceu e a razão chances estimada foi de 4,09 (IC95%: 1,19 - 14,04; p = 0,01. CONCLUSÕES: os resultados indicam uma forte associação entre exposição precoce ao leite de vaca e ocorrência de Diabetes Mellitus tipo1 na população estudada. Assim, crianças expostas precocemente ao leite de vaca apresentam uma chance maior de adquirir a doença quando comparadas àquelas que receberam aleitamento materno exclusivo até pelo menos quatro meses após o nascimento.OBJECTIVES: to study the relationship between early exposure to cow's milk and Diabetes Mellitus, type 1 among children under 18 years old seen at the Hospital Universitário Alcides Carneiro, in Campina Grande. METHODS: case-control study. Sample of 128 individuals of both sexes. Sixty-four mothers with Diabetes Mellitus type 1 and 64 mothers of a control group. Univariate and multivariate analysis was accomplished through logistic and conditional regression. RESULTS: 84,4% of diabetic individuals were exposed to cow mild before four months of age while in the control group this percentage was 64,1%. Univariate analysis determined a significant statistic association between

  6. Caracterização de pacientes com diabetes mellitus tipo 1 do sul do Brasil: complicações crônicas e fatores associados Characterization of patients with type 1 diabetes mellitus in southern Brazil: chronic complications and associated factors

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    Ticiana C. Rodrigues

    2010-01-01

    Full Text Available OBJETIVO: Avaliar a prevalência de complicações crônicas vasculares e fatores associados em pacientes com diabetes mellitus (DM tipo 1. MÉTODOS: Estudo transversal com pacientes DM tipo 1 atendidos no Serviço de Endocrinologia do Hospital de Clínicas de Porto Alegre. Os pacientes foram avaliados quanto à presença de complicações crônicas vasculares. RESULTADOS: Avaliamos 573 pacientes, idade média de 33 anos. A presença de retinopatia diabética (RD foi observada em 43,3%, o tempo de DM [RC: 1,07; IC95% 1,03-1,11; P 100 mg/dl. CONCLUSÃO: Observamos elevadas prevalências de complicações microvasculares e de HAS. A duração do DM, HAS e presença de ND foram associados à RD. HAS e dislipidemia foram associados à ND. A maioria dos pacientes encontrava-se fora dos alvos desejados de controle glicêmico, pressórico e lipídico. Maiores esforços são necessários para intensificar o controle metabólico e pressórico de pacientes com DM tipo 1.OBJECTIVE: To evaluate the prevalence of chronic vascular complications and associated factors in patients with type 1 diabetes mellitus (DM. METHODS: Cross sectional study with type 1 DM patients attending the Endocrine Division, Hospital de Clinicas de Porto Alegre. Patients were evaluated for presence of chronic vascular complications. RESULTS: We evaluated 573 patients, mean age of 33 years. The presence of diabetic retinopathy (DR was observed in 43.3%, diabetes duration [OR: 1.07, 95% CI: 1.03 to 1.11, P 100 mg/dl. CONCLUSION: We observed a high prevalence of microvascular complications and HPT. Duration of DM, HPT and presence of DN were associated with DR. HPT and dyslipidemia were associated with DN. Most patients did not meet the desired glycemic control, blood pressure and lipid targets. Greater efforts are needed to intensify the pressure and metabolic control of patients with type 1 DM.

  7. Efeito do tamoxifeno no perfil das proteínas plasmáticas em condição de diabetes mellitus tipo 1 Effect of tamoxifen on plasma proteins in diabetes mellitus type 1

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    Teresa Cristina P. Silva

    2005-01-01

    Full Text Available OBJETIVO: Considerando-se que importantes avanços científicos têm sido obtidos através de estudos com Diabetes mellitus experimental, e que a ação do tamoxifeno em humanos permanece obscura, o presente trabalho objetiva acompanhar as modificações promovidas pelo diabetes e tamoxifeno no perfil eletroforético das proteínas plasmáticas. MÉTODOS: Foram utilizados 27 ratos fêmeas Wistar (180-220g peso corporal, divididos randomicamente em 5 grupos: C1 (n=3, receberam veículo, C2 (n=3, sem tratamento, T (n=5, tratados com tamoxifeno, 0,3mg/kg/dia, D (n=8, diabéticos experimentais por estreptozotocina, 45mg/Kg e DT (n=8, diabéticos tratados com tamoxifeno. A eletroforese foi realizada em acetato de celulose, pH 8,6-8,8, cuba TECNOW, e as fitas foram coradas em Ponceau S. As proteínas totais foram determinadas pelo método do Biureto (Kit Labtest. Os proteinogramas foram obtidos em densitômetro BioSystems BTS-235. RESULTADOS: Albumina diminuiu progressivamente nos grupos T, D e DT; a fração a1 aumentou nos grupos T e DT; a fração a2 aumentou nos grupos T e D, havendo efeito aditivo no grupo DT; a fração b aumentou nos grupos T e D; a fração g aumentou nos grupos T, D e DT. CONCLUSÃO: Os resultados indicam uma resposta de fase aguda, com efeito aditivo do tamoxifeno e diabetes, sugerindo uma provável lesão hepática.PURPOSE: Considering that important scientific advances have been obtained through studies based on experimental Diabetes mellitus, and that tamoxifen action in humans remains unknown, the aim of the present work is to follow the modifications promoted by diabetes and tamoxifen in the electrophoretic profile of plasmatic proteins. METHODS: It was used 27 Wistar female rats (180-250 body weight, randomicaly divided into five groups: C1 (n=3, received vehicle, C2 (n=3, no treatment, T (n=5, treated with tamoxifen, 0.3mg/Kg/day, D (n=8, experimental diabetes by estreptozotocin, 45mg/Kg and DT (n=8, diabetic treated

  8. Pulp necrosis following luxated injury to teeth in a patient with uncontrolled type II diabetes mellitus: a case report

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    Haneol Shin,

    2012-02-01

    Full Text Available Patients with diabetes mellitus show delayed wound healing and increased susceptibility to infection. Therefore, the effects of diabetes on pulpal and periodontal healing should be taken into consideration when treating diabetic dental traumatized patients. This case presents the treatment for dental traumatized 20 yr old female with uncontrolled type II diabetes. The traumatized upper central incisors had showed pulpal healing in early days. However, 7 mon after the trauma, the teeth had been diagnosed with pulp necrosis with apical abscess. Eventually, non surgical root canal treatment on the teeth had been performed.

  9. Endothelial Nitric Oxide Synthase Gene Polymorphism (G894T and Diabetes Mellitus (Type II among South Indians

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    T. Angeline

    2011-01-01

    Full Text Available The objective of the study is to find out whether the endothelial nitric oxide synthase (eNOS G894T single-nucleotide polymorphism is associated with type 2 diabetes mellitus in South Indian (Tamil population. A total number of 260 subjects comprising 100 type 2 diabetic mellitus patients and 160 healthy individuals with no documented history of diabetes were included for the study. DNA was isolated, and eNOS G894T genotyping was performed using the polymerase chain reaction followed by restriction enzyme analysis using Ban II. The genotype distribution in patients and controls were compatible with the Hardy-Weinberg expectations (P>0.05. Odds ratio indicates that the occurrence of mutant genotype (GT/TT was 7.2 times (95% CI = 4.09–12.71 more frequent in the cases than in controls. Thus, the present study demonstrates that there is an association of endothelial nitric oxide synthase gene (G894T polymorphism with diabetes mellitus among South Indians.

  10. Cambios citomorfométricos en células de la mucosa oral de pacientes con diabetes mellitus tipo 2. Evaluación de su utilidad diagnóstica

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    Andrés Cornejo

    2016-09-01

    Full Text Available La citología exfoliativa ha mostrado previamente cambios citomorfométricos en descamados celulares orales en pacientes con diabetes mellitus tipo 2 (DB2. El objetivo de esta investigación fue determinar la capacidad de identificar la presencia de DB2 a partir de estos cambios. Mediante citología exfoliativa oral de pacientes diabéticos (n=30 y controles (n=30 se obtuvieron (en dos registros, con intervalo de un mes los valores de diámetro nuclear (DN, diámetro citoplasmático (DC, proporción núcleo:citoplasma (RNC y presencia/ausencia de cariorrexis y binucleación. Además se registraron los valores de glicemia capilar y hemoglobina glicosilada (Hb1Ac. El grupo DB2 mostró un aumento estadísticamente significativo del DN y RNC (valor p<0,05, Test t de Student en comparación con los pacientes sin diabetes. También se observó una asociación entre cariorrexis y binucleación (valor p<0,005, Test exacto de Fisher con DB2. El modelo de regresión logística binaria, que incluyó las variables DN y DC, explicó pobremente la varianza del diagnóstico, con una especificidad y sensibilidad moderada para la clasificación de los pacientes con DB2. Las células de la mucosa oral de pacientes con DB2 presentan un mayor diámetro nuclear y RNC, correlacionándose con los valores de glicemia, sin embargo no es posible clasificar a partir de estos análisis si los pacientes poseen DB2.

  11. Técnica para correção de truncus arteriosus tipos I e II sem condutos extracardíacos Technique for correction of truncus arteriosus type I and II without extracardiac conduits

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    Miguel Barbero-Marcial

    1989-04-01

    Full Text Available Uma nova técnica para correção cirúrgica do truncus arteriosus (TA sem o uso de conduto extracardíaco foi realizada em 7 pacientes, senão 6 do tipo I, e do tipo II em 1 paciente; a idade variou de 2 a 9 meses. O tronco comum foi septado com retalho, dividindo-o em uma posição aórtica e outra pulmonar; a comunicação interventricular (CIV foi fechada através de ventriculotomia; anastomose direta entre as artérias pulmonares e o ventrículo direito foi realizada, sendo a parede anterior construída com retalho de pericárdio bovino com válvula monocúspide. Houve apenas 1 óbito no pós-operatório. Nos 6 pacientes restantes, a relação entre as pressões sistólicas ventrículo direito/ventrículo esquerdo (VD/VE foi menor que 0,51 em 5 pacientes; em 1 paciente, essa relação foi de 0,60, associada a CIV residual. Todos os pacientes encontram-se em classe funcional I (NYHA, em um período de 1 a 14 meses de pós-operatório. Baseados nestes resultados, propomos esta técnica para pacientes com TA tipo I ou II, no primeiro ano de vida.A new corrective surgery for truncus arteriosus (TA without the use of extracardiac conduit was employed in 7 patients with truncus (TA type I in 6 cases and type II in 1 case, aged from two to nine months. The common TA was septated with a patch into aortic and pulmonary segments and the ventricular septal defect was closed through ventriculotomy; a direct anastomosis between the pulmonary arteries and the right ventricle was performed, the anterior wall of this, being contructed with a patch with a monocusp valve. There was one imediate postoperative death. In the surviving six patients the RV/LV postoperative peak systolic was less than 0.51 in five and 0.60 in one with residual VSD; all are in functional class I, in postoperative period between one and fourteen months. Based in these results we propose this technique for patients with type I or II, in the first year of life.

  12. Prevention of type II diabetes mellitus in Qatar: Who is at risk?

    Science.gov (United States)

    Christos, Paul J; Chemaitelly, Hiam; Abu-Raddad, Laith J; Ali Zirie, Mahmoud; Deleu, Dirk; Mushlin, Alvin I

    2014-01-01

    Type II diabetes mellitus (DM) is one of the leading chronic diseases in Qatar as well as worldwide. However, the risk factors for DM in Qatar and their prevalence are not well understood. We conducted a case-control study with the specific aim of estimating, based on data from outpatients with DM in Qatar (cases) and outpatient/inpatient controls, the association between demographic/lifestyle factors and DM. A total of 459 patients with DM from Hamad General Hospital (HGH) outpatient adult diabetes clinics, and 342 control patients from various outpatient clinics and inpatient departments within Hamad Medical Corporation (HMC) (years 2006-2008), were recruited. The association between risk factors and DM was evaluated using bivariate and multivariable logistic regression analyses. In addition to odds ratios (OR) and 95% confidence intervals (95% CI), we estimated the population attributable risk fractions for the DM demographic/lifestyle risk factors. Qatari nationality was the strongest risk factor for DM (adjusted OR = 5.5; 95% CI = 3.5-8.6; p 65 years (adjusted OR = 3.3; 95% CI = 0.9-11.4; p = 0.06), male gender (adjusted OR = 2.9; 95% CI = 1.8-4.8; p nationals, obesity was found to be the main risk factor for DM (unadjusted OR = 3.0; 95% CI = 1.6-5.6; p nationals. Promoting physical activity may reduce the burden of DM by up to 9.4% for the population at large and up to 17.3% for Qatari nationals. Demographic/lifestyle factors appear to be the main risk factors for the high DM levels observed in Qatar, with a contribution that outweighs that of genetic risk factors. While further evaluation of DM risk factors among the Qatari population (as opposed to the resident population) is important and of interest, these findings highlight the need to focus short-term DM interventions on addressing demographic/lifestyle risk factors to achieve substantial and timely declines in DM levels.

  13. Efectividad de la educación diabetológica sistematizada en niños que debutan con Diabetes Mellitus tipo 1 Effectiveness of systematic diabetes education in children diagnosed with Diabetes Mellitus type 1 (DM1

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    Manuel Montilla-Pérez

    2012-06-01

    Full Text Available Objetivo principal: Evaluar la efectividad de la educación diabetológica sistematizada en niños que debutan con DM1 en el Hospital Universitario de Fuenlabrada (HUF, Madrid. Metodología: Estudio comparativo entre dos muestras de niños de 0 a 14 años que debutaron con DM1 antes y después de haberse instaurado un programa de educación diabetológica Se estudió a 34 niños adscritos al HUF que ingresaron por debut de DM1. Para evaluar la efectividad del programa se realizaron análisis bivariados con el fin de encontrar relaciones entre la educación diabetológica sistematizada y las variables: días de ingreso, frecuentación a urgencias por complicaciones, permisos domiciliarios y HbA1c a los 3 y 6 meses del alta. Resultados principales: Los días de ingreso se redujeron 3 días (pObjective: Evaluate the effectiveness of systematic diabetes education in children diagnosed with Diabetes Mellitus type 1 (DM1, in Fuenlabrada University Hospital (Madrid. Methods: A comparative study of two sample groups of children aged 0 to 14 diagnosed with DM1, before and after having been inducted into the diabetes education program. 34 children, admitted with a DM1 diagnosis, both with and without ketoacidosis, and assigned to Fuenlabrada University Hospital were studied. To evaluate the effectiveness of the program, bivariable analysis was undertaken with the objective of finding relationships between systematic diabetes education and the variables. Those variables were; admission days, frequency of visits to the emergency ward due to complications, and permissions to go home and HbA1c at 3 to 6 months after discharge from the hospital. Results: The admission days was reduced 3 days (p< 0.001, the complications within the 6 month after discharge decreased 41,2% and the permissions to go home increased 23,6% (p=0.001. Conclusions: The results of the study suggest the effectiveness of systematic diabetes education.

  14. Los niños del Cauca II. Receptor de la vitamina D con secuencia normal en un foco de pacientes con raquitismo dependiente de la vitamina D, tipo II

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    Luis Fernando García-Ramirez

    1993-12-01

    Full Text Available El Raquitismo Dependiente de Vitamina D, tipo II (RDVD II, es una enfermedad de herencia autosómica recesiva que se caracteriza por resistencia generalizada a la 1,25-dihidroxivitamina D, originada en alteraciones que comprometen la función del receptor para la vitamina D (RVD. El clonaje y caracterización del cDNA del RVD ha permitido el estudio de su secuencia en pacientes con RDVD II y el hallazgo de diversas mutaciones puntuales que explican el cuadro clínico. En este estudio, hemos utilizado las técnicas de PCR y clonación, para secuenciar el RVD de dos pacientes pertenecientes a un foco descrito previamente en el departamento del Cauca (Colombia, cuyas manifestaciones clínicas y de laboratorio son compatibles con RDVD II. La secuencia del RVD de nuestros pacientes fue normal, sugiriendo una alteración a nivel postranscripcional o postraduccional relacionada con la función del receptor, en lo que podría corresponder a una nueva variante de resistencia a la vitamina D.

  15. Pesquisa do nistagmo/vertigem de posição e avaliação eletronistagmográfica em um grupo de indivíduos portadores de diabetes Mellitus tipo I Search of the nystagmus/ positional vertigo and electronystagmographic evaluation in a group of diabetics Mellitus type I

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    Lílian P. Scherer

    2002-05-01

    Full Text Available Introdução: De acordo com a Sociedade Brasileira de Diabetes, estima-se que existam no Brasil cerca de 5 milhões de pessoas com a patologia. No estado do Rio Grande do Sul há, provavelmente, 400.000 pacientes diabéticos23,27. Dentre as alterações que os indivíduos portadores de diabetes Mellitus podem apresentar, estão incluídos os distúrbios vestibulares. Objetivo: O presente trabalho teve por objetivo colaborar nas pesquisas de melhoria na qualidade de vida do paciente diabético e realizar pesquisa do nistagmo/ vertigem de posição e eletronistagmografia, a fim de identificar possíveis alterações. Forma de estudo: Clínico prospectivo. Material e método: 12 indivíduos portadores de diabetes Mellitus tipo I, usuários regulares de insulina, com idades entre 12 e 27 anos e componentes da Associação Riograndense de Apoio aos Diabéticos (ARAD. Para verificar as respostas vestibulares nos indivíduos portadores de diabetes Mellitus tipo I, foram realizados anamnese específica, meatoscopia, timpanometria, pesquisa do nistagmo/ vertigem de posição e eletronistagmografia na amostra selecionada. Resultados: Verificou-se Síndrome Vestibular Periférica Irritativa em 75% dos resultados alterados. Destes, 62,5% se tratavam de sujeitos sem queixa otoneurológica. Conclusões: Observou-se que o efeito do diabetes tipo I, na função vestibular, deve ser avaliado como as demais complicações diabéticas usuais, mesmo em pacientes assintomáticos, pois, com o diagnóstico etiológico precoce, é possível o auxílio na prevenção das complicações desta patologia.Introduction: According to the Brazilian Society of Diabetes, there are 5 million diabetics in Brazil. In the state of Rio Grande do Sul only, there are, probably, 400.000 diabetics23,27. This group of people can present vestibular alterations. Aim: This article had the objective to contribute with the searches to help improve the quality of life of the diabetics and to

  16. Prevalence and distribution of type 2 diabetes mellitus in Mexican adult population: a probabilistic survey Prevalencia y distribuición de la diabetes mellitus tipo 2 en población adulta mexicana: una encuesta probabilística

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    Salvador Villalpando

    2010-01-01

    Full Text Available OBJECTIVE: To describe the prevalence, distribution and degree of control of type 2 diabetes (T2D in Mexican population. MATERIAL AND METHODS: Subjects were classified as previously diagnosed T2D (PD; or as "finding of the survey" (FS (glucose >126 mg/dL. Hemoglobin A1c was measured in PD-subjects. RESULTS: The prevalence for PD-T2D was 7.34% (95%CI 6.3, 8.5 and for FS 7.07% (95%CI 6.1, 8.1, summing 14.42%; (7.3 million diabetics. 5.3% of PD-T2D were in good, 38.4% in poor and 56.2% very poor control. Older age (OR=0.96, 95%CI 0.94, 0.97, lower BMI (OR=0.95, 95%CI 0.91, 1.0, were protective for poor control. Affiliation to private services (OR=1.77, 95%CI 0.98, 3.13, larger T2D duration (OR=1.05, 95%CI 1.01, 1.08, and combining oral medication and insulin (OR=16.1, 95%CI 1.61, 161 were riskier. CONCLUSIONS: We found an alarming prevalence of T2D in Mexican population; the majority of PD diabetics are in poor control. Research on the latter is warranted.OBJETIVO: Describir la prevalencia, distribución y grado de control de diabetes tipo 2 (DT2 en población mexicana. MATERIAL Y MÉTODOS: Los sujetos fueron clasificados como "previamente diagnosticados" (PD o "hallazgos de la encuesta" (FS (glucosa >126 mg/dL. La hemoglobina A1c se midió en DT2-PD. RESULTADOS: La prevalencia de DT2-PD fue 7.34% (IC95% 6.3, 8.5 y 7.07%.(IC95% 6.1, 8.1 para FS, sumando 14.42% (7.3 millones de diabéticos. Los DT2-PD tenían 5.3% control bueno, 38.4%, malo y 56.2% muy malo. Tener mayor edad (RM=0.96, IC95% 0.95, 0.97 o IMC más bajo (RM=0.95, IC95% 0.91, 1.0 fueron protectores contra mal control. Atenderse en servicios médicos privados (RM=1.77, IC95% 0.98, 3.13, larga duración de DT2 (RM=1.05, IC95% 1.01, 1.08 o recibir hipoglucemiantes más insulina (RM=16.1, IC95% 1.61, 161 fueron de riesgo. CONCLUSIONES: Existe una prevalencia alarmante de DT2 en la población mexicana, la mayoría de los PD-DT2 tenían mal control glicémico. Se necesita más investigaci

  17. Expansion design for a radioactive sources handling laboratory type II class B; Diseno de ampliacion para un laboratorio de manejo de fuentes radiactivas tipo II clase B

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez S, P. S. [Universidad Mexiquense del Bicentenario, Av. Industria Poniente s/n, Parque Industrial Dona Rosa, 52000 Lerma, Estado de Mexico (Mexico); Monroy G, F.; Alanis, J., E-mail: salvador-21@live.com.mx [ININ, Carretera Mexico-Touca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2013-10-15

    The Radioactive Wastes Research Laboratory (RWRL) of the Instituto Nacional de Investigaciones Nucleares (Mexico), at the moment has three sections: instrumental analysis, radioactive material processes, counting and a license type II class C, to manipulate radioactive material. This license limits the open sources handling to 300 kBq for radionuclides of very high radio-toxicity as the Ra-226, for what is being projected the license extension to type II class B, to be able to manage until 370 MBq of this radionuclides type, and the Laboratory, since the location where is the RWRL have unused area. This work presents a proposal of the RWRL expansion, taking into account the current laboratory sections, as well as the established specifications by the Comision Nacional de Seguridad Nuclear y Salvaguardias (CNSNS). The current planes of the RWRL and the expansion proposal of the laboratory are presented. (Author)

  18. Expansion design for a Laboratory of Radioactive Sources Handling type II, class B; Diseno de ampliacion para un Laboratorio de Manejo de Fuentes Radiactivas tipo II, clase B

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez S, P. S.

    2014-07-01

    This work presents the expansion design of the Radioactive Wastes Research Laboratory (RWRL) installation authorized by the Comision Nacional de Seguridad Nuclear y Salvaguardias (Mexico) as type II class C, to manage 40 different radionuclides, approximately. The RWRL has 4 areas at the present time: a laboratory of instrumental analysis, one of radioactive material processes, other of counting and a chemical reagents stock, which is not integrated to the operation license of the RWRL. With the purpose of expanding the operation license of the RWRL to an installation type II class B, to manage until 370 MBq of high radio toxicity radionuclides, is presented in this work an expansion proposal of the RWRL. The expansion proposal is based in: (1) the Mexican Nuclear Standard NOM-027-Nucl-1996 for installations type II class B, (2) the current distribution of water, light, electricity, extraction, gas, air and vacuum services of RWRL, and (3) the available areas inside the building that the RWRL occupies. The proposal contemplates the creation of additional new areas for RWRL: 3 laboratories, 2 dressing rooms, 2 bathrooms and 2 warehouses, one for radioactive materials and another for reagents chemical radiologically inactive. Architectural, electric, hydraulic, extraction and gas planes corresponding to the expansion of RWRL were realized. Inside the proposal the budget required to carry out the mentioned expansion is also presented. (Author)

  19. Caracterización clínica y epidemiológica de los pacientes menores de 15 años de edad con diabetes mellitus tipo 1 Clinical-epidemiologic characterization of patients aged under 15 presenting with type 1 diabetes mellitus

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    Juliette Navarrete Cabrera

    2012-04-01

    Full Text Available Objetivo: identificar las características clínico epidemiológicas de los pacientes menores de 15 años de edad, diagnosticados con diabetes mellitus tipo 1 durante el período comprendido entre el 1º de enero de 2000 y el 31 de diciembre de 2008 de la provincia Ciudad de La Habana. Métodos: se realizó un estudio descriptivo-retrospectivo con los pacientes menores de 15 años de edad, diagnosticados con diabetes mellitus tipo 1 durante el período ya mencionado. El grupo de estudio estuvo constituido por 293 pacientes, a los que se realizó la revisión de la historia clínica. Las variables estudiadas fueron: sexo, edad al diagnóstico, color de la piel, duración de lactancia materna exclusiva, forma clínica al diagnóstico y factores ambientales. Se realizó el análisis estadístico mediante cálculo de por cientos y de tasas de incidencia por grupo de edad y sexo durante el período estudiado. Resultados: los resultados más importantes mostraron un predominio de los pacientes que recibieron lactancia materna exclusiva por un tiempo menor de 3 meses. Las formas clínicas menos graves al diagnóstico de la enfermedad fueron las más frecuentes. Entre los factores ambientales predominaron las enfermedades respiratorias agudas. La tasa de incidencia media del período fue de 8,4 x 100 000 habitantes. Conclusiones: la incidencia de la enfermedad durante el período fue más alta en relación con los estudios previos realizados en el país, con un desplazamiento hacia edades tempranas.Objective: to identify the clinical-epidemiologic features of the patients aged under 15, diagnosed with type 1 diabetes mellitus from January 1, 2000 to December 31, 2008 from Ciudad de La Habana province. Methods: a descriptive-retrospective study was conducted in patients aged under 15 diagnosed with type 1 diabetes mellitus over above mentioned period. The study group included 293 patients and the review of medical record. Study variables were: sex, age

  20. Tratamiento de la diabetes mellitus tipo 2 en el municipio de Güines, año 2002: Análisis con énfasis en la terapia medicamentosa Treatment of type 2 diabetes mellitus in Güines municipality in the year 2002: Drug therapy-based analysis

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    José Luis Valenciaga Rodríguez

    2003-08-01

    Full Text Available Se realizó una investigación de corte transversal con el objetivo de identificar las características del tratamiento en personas con diabetes mellitus tipo 2 pertenecientes al municipio de Güines, en el año 2002, específicamente en la utilización de compuestos orales normo o hipoglucemiantes e insulina. El universo lo constituyeron 3 017 diabéticos tipo 2 registrados en el municipio en el año 2001, y la muestra 328 de estos casos, seleccionados a través de diseño muestral complejo (estratificado en la primera etapa y por conglomerados en la segunda. Los datos obtenidos se procesaron estadísticamente, con el empleo del programa SPSS (versión 10. La media de edad de la muestra fue de 65, 2 años y de 12,8 de la fecha de diagnóstico. Un total de 161 personas (49,1 % se trataba con dieta solamente y 42 con insulina; de ellos todos empleaban insulina de acción intermedia y 3 (7,1 % la de acción rápida. El compuesto hipoglucemiante más utilizado fue la Glibenclamida, en 131 casos (85,5 %, y su dosis media diaria fue de 15 mg, mientras aproximadamente 1 de cada 10 casos empleaba medicina verde. Se concluye que existen deficiencias en el manejo terapéutico, específicamente en la forma de utilización de insulina, escasa disponibilidad de compuestos orales normo o hipoglucemiantes y alta frecuencia de tratamiento no farmacológico. Se recomienda reanalizar el cumplimiento del Programa Nacional de Diabetes Mellitus en el municipio de Güines, con énfasis en la capacitación del personal de salud en aspectos terapéuticos, así como incrementar la disponibilidad de compuestos orales normo o hipoglucemiantes, específicamente de Metformin, en el municipio.A cross-sectional study was made to identify the characteristics of treatment of persons with type 2 diabetes mellitus in Güines municipality during 2002, particularly the use of oral normo or hypoglicemic compounds and insulin. The universe was made up of 3 017 type 2 diabetics

  1. Construcción y validación inicial de un instrumento para medir el estilo de vida en pacientes con diabetes mellitus tipo 2 Development and initial validation of an instrument to measure lifestyle of type 2 diabetes mellitus patients

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    Juan Manuel López-Carmona

    2003-08-01

    Full Text Available OBJETIVO: Construir y validar un instrumento específico para medir el estilo de vida en los pacientes con diabetes mellitus tipo 2. MATERIAL Y MÉTODOS: Entre marzo de 2001 y abril de 2002 se hizo un estudio observacional, longitudinal y prospectivo en unidades de medicina familiar de la delegación Estado de México Oriente, del Instituto Mexicano del Seguro Social. Se diseñó un instrumento de autoadministración, denominado instrumento para medir el estilo de vida en diabéticos, el cual fue sometido a revisión por un panel multidisciplinario de expertos para determinar su validez lógica y de contenido. Se aplicó el instrumento en dos días diferentes a 412 sujetos adultos con diabetes mellitus. Fueron depurados los ítems considerando la frecuencia de selección de sus opciones de respuesta, su correlación ítem-total y su carga significativa en los dominios durante el análisis factorial. RESULTADOS: Completaron el estudio 389 (94.7% sujetos. Los coeficientes de correlación intra-clase para la validez lógica y de contenido fueron de 0.91 y 0.95, respectivamente. Después de la depuración de ítems se obtuvo un instrumento conformado por 25 preguntas cerradas, distribuidas en siete dominios: nutrición, actividad física, consumo de tabaco, consumo de alcohol, información sobre diabetes, emociones y adherencia terapéutica. El a de Cronbach para la calificación total fue de 0.81 y el coeficiente de correlación test-retest de 0.84. CONCLUSIONES: El instrumento para medir el estilo de vida en diabéticos es el primer cuestionario específico para sujetos con diabetes mellitus tipo 2 y tiene validez aparente, validez de contenido y buen nivel de consistencia.OBJECTIVE: To develop and validate a specific instrument to measure lifestyle of type 2 diabetes mellitus (DM2 patients. MATERIAL AND METHODS: A longitudinal, observational, prospective study was conducted between March 2001 and April 2002 at family medicine healthcare units of

  2. Relationship between insulin resistance and blood lipid and sport in patients with type II diabetes mellitus complicated with hypertension%2型糖尿病合并高血压患者胰岛素低抗

    Institute of Scientific and Technical Information of China (English)

    谭丽艳; 杨红玉; 柴国禄; 沈凌元

    2001-01-01

    Objective To study the relationship between insulin resistance and blood pressure and blood lipid in patients with type II diabetes mellitus complicated with hypertension.Methods The serum concentration of fasting glucose,insulin,lipids and the level of blood pressure were measured in 56 patients with type II diabetes mellitus complicated with hypertension.Results The insulin sensitivity index(ISI) decreased in patients with type II diabetes mellitus complicated with hypertension compared with the patients with type II diabetes mellitus with normal blood pressure(P< 0.05).A negative correlation with hypertension was found between ISI and SBP,DBP,TG,ApoB in patients with type II diabetes mellitus complicated with hypertension(P<0.05).There was a positive correlation between ISI and HDL in patients with type II diabetes mellitus complicated with hypertension(P<0.05).Conclusion Insulin resistance presents in patients of type II diabetes mellitus complicated with hypertension.Insulin resistance is the major cause of hypertension and lipid metabolic disturbance in patients with type II diabetes mellitus complicated with hypertension.

  3. Estudio de pacientes con aciduria glutárica tipo II, mediante la incubación de fibroblastos con ácidos palmítico y mirístico tritiados = Study of patients with type II glutaric aciduria by incubation of fibroblasts with tritiated palmitic and myristic acids

    Directory of Open Access Journals (Sweden)

    Osorio Orozco, José Henry

    2011-09-01

    Full Text Available Introducción: la aciduria glutárica tipo II, o deficiencia múltiple de acil-CoA deshidrogenasas, es un trastorno causado por deficiencia de la flavoproteína de transferencia de electrones, de su oxidorreductasa o de ambas; se trata de una enfermedad metabólica autosómica recesiva, caracterizada por acidosis, hipoglicemia, aciduria orgánica, olor a pies sudados y malformaciones en cerebro y riñones.Objetivo: analizar las tasas de oxidación de sustratos tritiados por fibroblastos de pacientes con aciduria glutárica tipo II.Materiales y métodos: se incubaron fibroblastos de dos pacientes con aciduria glutárica tipo II y de 20 controles en presencia de ácidos palmítico y mirístico tritiados.Resultados: se encontró muy deprimida (16%-18% la oxidación de los sustratos tritiados por los fibroblastos procedentes de pacientes con aciduria glutárica tipo II en comparación con los controles.Conclusión: la prueba estudiada permite la confirmación in vitro del diagnóstico de aciduria glutárica tipo II.

  4. Influencia epigenómica de la actividad/inactividad física en el origen de la Diabetes mellitus tipo 2. (Epigenomic influence of the physical activity/inactivity in the origin of type 2 diabetes.

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    José Luís Márques Andrade

    2009-07-01

    Full Text Available Resumen Contrariamente al modelo centrado en las mutaciones, el cual asume que alteraciones en la función son consecuencia de mutaciones somáticas o heredadas en la secuencia del DNA, el modelo epigenético implica una carencia de regulación de uno o más genes. Un componente crítico del epigenoma son los patrones de distribución de las citosinas metiladas en secuencias de dinucleótidos CpG. Tal metilación marca los genes para su inactivación al interferir con la unión de factores de transcripción sensibles a DNA metilado o bien al reclutar proteínas que agrupan complejos correpresores y deacetilasas de histonas en torno a la cromatina. Estas marcas epigenéticas son propagadas luego mitótica y en algunos casos meióticamente, resultando en una herencia estable de estados regulatorios. Hoy se sabe que la dieta u otros factores ambientales son un punto de control para la regulación de la expresión génica y que durante periodos críticos de desarrollo, la cromatina sería particularmente sensible a modificaciones epigenómicas. De esta manera una explicación epigenómica del origen fetal de las enfermedades crónicas del adulto parece razonable. La presente revisión explica cómo la actividad/inactividad física de la madre o de la progenie en etapas tempranas, puede predisponer a Diabetes mellitus tipo 2 en la vida adulta a través de este mecanismo.AbstractContrary to the model centered in the mutations, which assumes that alterations in the function are consequence of somatic or inherited mutations in the sequence of the DNA, the epigenetic model implies dysregulation of one or more genes. A critical component of epigenome is its distribution patterns of the methylated cytosines in CpG sequences. This methylation marks to genes for their inactivation interfering with the union of methylated DNA-sensible transcription factors or recruiting proteins that group corepressor complexes and histone deacetylases around of chromatin

  5. Avaliação genética e oftalmológica de pacientes com síndrome de Stickler tipo II Genetic and ophthalmological assessment of patients with type II Stickler syndrome

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    Vanderson Glerian Dias

    2006-12-01

    Full Text Available OBJETIVOS: Diagnosticar, avaliar e descrever os achados clínico-genéticos e oftalmológicos de pacientes com síndrome de Stickler tipo II de uma mesma família. MÉTODOS: Todos os pacientes com alterações oftalmológicas foram submetidos à radiografia de mãos e punhos para idade óssea e posteriormente analisados pelo exame clínico-genético. O diagnóstico de síndrome de Stickler foi dado mediante análise clínica e correlação com o perfil metacarpofalangeano visualizado na radiografia. RESULTADOS: Síndrome de Stickler tipo II foi comprovada em 11 pacientes. Os achados oculares mais importantes foram: alta miopia (80%, subluxação do cristalino (70%, exotropia (50% e anomalias vítreo-retinianas (80% incluindo vazio vítreo (50%. O exame clínico-genético revelou que 30% dos pacientes apresentavam micrognatia, 50% hipoacusia, 40% depressão nasal e 60% palato alto. Hipermotilidade articular e dedos longos foram demonstrados em 7 casos (70% e artropatia esteve presente em 3 pacientes (30% dos casos. CONCLUSÕES: O diagnóstico da síndrome de Stickler é difícil devido à variabilidade fenotípica e a existência de outras síndromes genéticas com características semelhantes. As radiografias de mão e punho são de particular importância no diagnóstico desta síndrome.PURPOSE: To diagnose, evaluate and describe the clinical, genetic and ophthalmic characteristics of a family with type II Stickler syndrome. METHODS: X-rays for bone age, clinical and genetic evaluation were performed in all patients with ocular alterations. The Stickler syndrome diagnosis was established after correlating these examinations. RESULTS: Type II Stickler syndrome was found in 11 patients. The most important ocular findings were: high myopia (80%, lens subluxation (70%, exotropia (50% and vitreoretinal abnormalities (80% including vitreous cavity (50%. The clinical genetic examination disclosed that 30% of the patients had micrognathia, 50% hearing

  6. Complicações microvasculares e disfunção autonômica cardíaca em pacientes com diabete melito tipo 1 Complicaciones microvasculares y disfunción autonómica cardíaca en pacientes con diabetes mellittus tipo 1 Microvascular complications and cardiac autonomic dysfunction in patients with diabetes mellitus type 1

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    Fernando K Almeida

    2011-06-01

    hallazgos sugestivos de NAC durante la realización de la prueba ergométrica (PE y nefropatía y retinopatía en pacientes con DM tipo 1. METHODS: Realizamos un estudio transversal con 84 pacientes con DM tipo 1. Todos los pacientes fueron sometidos a evaluación clínica y laboratorial y llevaron a cabo PE, siendo que aquellos que presentaron hallazgos sugestivos de isquemia miocárdica fueron excluidos del análisis de los datos (n = 3. La evaluación de complicaciones microvasculares (retinopatía y nefropatía se realizó en la muestra. RESULTS: Los pacientes con nefropatía y aquellos con retinopatía alcanzaron una frecuencia cardíaca (FC durante el nivel máximo de ejercicio (FC máxima menor y presentaron aumento menor de FC con relación al reposo (ΔFC pico cuando comparados con aquellos sin estas complicaciones. Estos pacientes también presentaron una menor reducción de la FC en el segundo y 4º minutos tras el final de la prueba (ΔFC recuperación 2 y 4 minutos. Tras la realización de análisis multivariado con control para los posibles factores de confusión, los ΔFC recuperación en dos y 4 minutos, FC máxima y el ΔFC pico permanecieron significativamente asociados a la retinopatía; y los ΔFC recuperación en el segundo y 4º minutos permanecieron asociados a la presencia de nefropatía. CONCLUSION: Se puede considerar la PE como un instrumento adicional para la detección precoz de NAC y para identificar pacientes en un mayor riesgo para complicaciones microvasculares de la diabetes.BACKGROUND: The presence of cardiac autonomic neuropathy (CAN in patients with diabetes mellitus (DM is associated with increased mortality and chronic microvascular complications of diabetes. OBJECTIVE: To investigate a possible association between specific findings of CAN during exercise testing (ET and nephropathy and retinopathy in patients with type 1 DM. METHODS: We conducted a cross-sectional study of 84 patients with type 1 DM. All patients underwent clinical

  7. Controle inadequado da pressão arterial em pacientes com diabete melito tipo 2 Control inadecuado de la presión arterial en pacientes con diabetes melito tipo 2 Inadequate blood pressure control in patients with type 2 diabetes mellitus

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    Lana C. Pinto

    2010-05-01

    Full Text Available FUNDAMENTO: Existem evidências indicando que o controle pressórico é mais efetivo na redução de complicações macrovasculares do diabete melito (DM do que o controle glicêmico. No entanto, a redução da PA para os níveis recomendados pelas diretrizes é difícil na prática clínica. OBJETIVO: Avaliar o percentual de pacientes que apresentavam simultaneamente DM tipo 2 e hipertensão arterial sistêmica (HAS, atendidos em hospital terciário, com controle pressórico adequado, e determinar os fatores clínicos e laboratoriais associados. MÉTODOS: Estudo transversal com 348 pacientes com DM tipo 2 e HAS atendidos no ambulatório de Endocrinologia do Hospital de Clínicas de Porto Alegre. Os pacientes foram submetidos à anamnese, exame físico, com medida da pressão arterial (PA, e foi coletada amostra de sangue e urina para análise laboratorial. Os pacientes foram divididos em três grupos: controle pressórico ideal (FUNDAMENTO: Hay evidencias indicando que el control de presión es más efectivo en la reducción de complicaciones macrovasculares de la diabetes melito (DM que el control glucémico. Sin embargo, la reducción de la PA para los niveles recomendados por las directrices es difícil en la práctica clínica. OBJETIVO: Evaluar el porcentual de pacientes que presentaban simultáneamente DM tipo 2 y hipertensión arterial sistémica (HAS, atendidos en hospital terciario, con control de presión adecuado, y determinar los factores clínicos y laboratoriales asociados. MÉTODOS: Estudio transversal con 348 pacientes con DM tipo 2 y HAS atendidos en el ambulatorio de Endocrinología del Hospital de Clínicas de Porto Alegre. Los pacientes fueron sometidos a anamnesis, examen físico, con medición de la presión arterial (PA, y se recolectó muestra de sangre y orina para análisis laboratorial. Los pacientes se dividieron en tres grupos: control de presión ideal ( 140/90 mmHg. RESULTADOS: El promedio de edad fue de 61,2

  8. Características clínicas de la diabetes mellitus tipo 2 en el municipio de Güines: Año 2002 Clinical Characteristics of diabetes mellitus type 2 in the municipality of Guines in the year 2002.

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    Oscar Díaz Díaz

    2003-04-01

    Full Text Available Se realizó una investigación descriptiva, retrospectiva y de corte transversal con el objetivo de identificar las características clínicas de la diabetes mellitus tipo 2 en el municipio de Güines en el año 2002. El universo lo constituyeron 3 017 diabéticos tipo 2 registrados en el citado municipio en el año 2001 y la muestra 328 de estos casos, seleccionados a través de un muestreo complejo (estratificado en la primera etapa y por conglomerados en la segunda. Los resultados se procesaron estadísticamente (Programa SPSS, versión 10. La media de edad fue de 65,2 años. Existió malnutrición por exceso en 221 individuos (67,4 %; 111 eran hipertensos; de ellos solo 32 (28,8 % estaban controlados. La toma fortuita de tensión arterial realizada durante la investigación detectó cifras normales en solo 45 (49,5 % personas. De 217 diabéticos no dispensarizados como hipertensos, 63 (29,1 % tenían cifras elevadas en la citada medición fortuita. Las complicaciones crónicas más frecuentes fueron la polineuropatía periférica, la cardiopatía isquémica y la retinopatía diabética con 85 (25,9 %, 79 (24,1 % y 78 (23,8 % respectivamente; El control glucémico fue bueno o aceptable en 175 encuestados (53,0 % Existió alta frecuencia de diabéticos tipo 2 con descontrol glucémico entre los casos evaluados, así como subregistros en la información obtenida por historias clínicas ambulatorias, sobre todo en relación con complicaciones crónicas e hipertensión arterial.Retrospective descriptive cross-sectional research study was made to identify the clinical characteristics of diabetes mellitus type 2 in the municipality of Güines, Habana province, in the year 2002. The universe of study was made up of 3 017 type 2 diabetics, who had been registered in this municipality in 2001, whereas the sample was composed by 328 cases selected from a complex sampling process (stratified in the first stage and by conglomerates in the second phase

  9. Frecuencia y características clínicas de la retinopatía diabética en un grupo de personas con diabetes mellitus tipo 2 de diagnóstico reciente Frequency and clinical characteristics of diabetic retinopathy in a group of persons recently diagnosed with type 2 diabetes mellitus

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    Manuel E. Licea Puig

    2003-08-01

    Full Text Available En los últimos años se le ha dedicado mayor atención a la presencia de complicaciones microangiopáticas en las personas con diabetes mellitus tipo 2 (DM 2, y la retinopatía diabética (RD no es una excepción. El objetivo de este trabajo es determinar la frecuencia y las características clínicas de la RD en un grupo de personas con DM 2 de diagnóstico reciente. Se estudiaron 110 pacientes (£ 6 meses con anticuerpos antiislotes pancreáticos (ICA y anti-descarboxilasa del ácido glutámico (AGAD negativos, atendidos consecutivamente en el Centro de Atención al Diabético (CAD, del Instituto Nacional de Endocrinología (INEN, y las variables utilizadas fueron: edad, sexo, hábito de fumar, índice de masa corporal (IMC, edad de debut de la DM 2, presencia de RD y de nefropatía diabética incipiente (NDI, así como la presión arterial. Se determinó ICA, AGAD, hemoglobina glucosilada (HbA1, glucemia en ayunas y posprandial 2 horas después del desayuno y 2 horas después del almuerzo y excreción urinaria de albúmina (EUA en orina de 24 horas. No se incluyó a pacientes con ND diabética clínica (EUA ³ 300 mg/L, ni con otras causas o condiciones de aumento de EUA. Se dividieron en 2 grupos atendiendo a la presencia o no de RD, así como a su severidad y fueron utilizados los criterios propuestos por L'Esperance. El 7 % de la totalidad de la serie presentó algún tipo de RD (7 no proliferativas y 1 proliferativa. La presión arterial sistólica fue de 127,84 ± 19,43 mmHg en aquellos sin RD y de 140 ± 15,27 mmHg , en los que presentaron RDNP (p 20 a In the last few years, great attention has been paid to microangiopathic complications occurred in persons with type 2 diabetes mellitus, and diabetic retinopathy is not the exception. The objective of this paper is to determine the frequency and the clinical characteristics of diabetic retinopathy in a group of persons recently diagnosed with type 2 diabetes mellitus. One hundred ten

  10. Effect of aqueous bark extract of Garuga pinnata Roxb. in streptozotocin-nicotinamide induced type-II diabetes mellitus.

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    Shirwaikar, Annie; Rajendran, K; Barik, Rakesh

    2006-09-19

    A study was undertaken to evaluate the antihyperglycemic activity of aqueous extract of bark of Garuga pinnata Roxb. (Burseraceae). The various parameters studied included fasting blood sugar levels, serum lipid levels, liver glycogen content, serum insulin level and glycated hemoglobin in diabetic and normal rats. Streptozotocin-nicotinamide was used to induce type-II diabetes mellitus. Treatment with the extract at two dose levels showed a significant increase in the liver glycogen and serum insulin level and a significant decrease in fasting blood glucose and glycated hemoglobin levels. The total cholesterol and serum triglycerides levels were also significantly reduced and the HDL cholesterol levels were significantly increased upon treatment with the extract thus proving the potent antidiabetic property of the plant.

  11. [Hypoglycemic action of different doses of nopal (Opuntia streptacantha Lemaire) in patients with type II diabetes mellitus].

    Science.gov (United States)

    Frati-Munari, A C; Del Valle-Martínez, L M; Ariza-Andraca, C R; Islas-Andrade, S; Chávez-Negrete, A

    1989-01-01

    To assess the relationship between the doses of O. streptacantha Lem. and its acute hypoglycemic action in diabetics, eight patients with type II diabetes mellitus were studied. Four test were performed to each patient with the intake of: (a) 400 ml of water, (b) 100 g (c) 300 g and (d) 500 g of broiled stems of O. streptacantha Lem. Serum glucose was measured at 0, 60, 120 and 180 minutes. Maximal decrease of serum glucose was noticed at 180 minutes, with a mean of 2.3, 10, 30.1 and 46.7 mg/dl less than basal value with 0, 100, 300 and 500 g respectively (P = NS, less than 0.05, less than 0.001 and less than 0.001 respectively). A significant direct correlation (r = 0.690, P less than 0.001) was noticed between the doses and the hypoglycemic effect.

  12. Assessment of Candidal carriage in patients with Type II Diabetes Mellitus

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    RS Lamichhane

    2015-03-01

    Full Text Available Background: It is generally acknowledged that patients with diabetes mellitus are more susceptible to fungal infections, particularly with Candida albicans. Oral infection by Candida can result in a number of clinical lesions, including median rhomboid glossitis (central papillary atrophy, denture stomatitis, squamous cell carcinoma, Radiation therapy, immunocompromised status, etc. Different studies have shown that patients with diabetes mellitus have increased frequency of oral candidal carriage and increased risk of candidiasis, which is related to poor metabolic control, neutrophil dysfunction, reduced salivary flow, high glucose concentration in blood and saliva and in medications.Materials and Methods: Subjects of both the groups were given 10 ml of sterile normal saline and asked to rinse the mouth for one minute. The subjects were then asked to return the oral rinse in a sterile clean, broad-mouthed container which was capped, labelled and taken to the laboratory. The samples were then inoculated onto the culture medium (Sabouraud’s dextrose agar with Chloramphenicol with minimal delay (within 6-8 hours of collection of oral rinse. Candidal colonies were counted and compared with non-diabetics.Results: Statistically significant increase in colony forming units (p=0.0324 were obtainedin patients with diabetes mellitus.Conclusion: The results indicate significant increase in colonization and carriage of candida in the oral cavity among diabetics when compared with non-diabetics. However, further research using larger samples is required which may lend credibility to the suggestion of increased candidal CFUs in diabetics serving as a surrogate marker of serum glucose levels.Journal of Pathology of Nepal (2015 Vol. 5, 733-738

  13. Validity of F-wave minimal latency of median and ulnar nerves for diagnosis and severity assessment of carpal tunnel syndrome in type II diabetes mellitus

    International Nuclear Information System (INIS)

    Hussain, A.; Habib, S.S.; Omar, S.A.; Drees, M.A.

    2011-01-01

    Type II diabetes mellitus is a common problem and is sometimes associated with Carpal Tunnel Syndrome (CTS) due to compression of median nerve at wrist. Electrophysiological tests are frequently used for its diagnosis. In this work, F-wave minimal latency (FWML) difference between median and ulnar nerve and F-ratio is used to facilitate the diagnosis and severity of CTS in type II diabetes mellitus (T2DM). Methods: Thirty control cases were selected who were physically fit for normal electrophysiological values. Thirty-two patients with a long history of type II diabetes mellitus were studied for electro-diagnostic tests. All patients had clinical evidence of CTS. Among all diabetics about 20 cases had poor glycaemic control (HbA1c>7.5). F-wave minimal latency (FWML) were measured in median and ulnar nerves and F-ratio of median nerve were also noted. The mean values in different groups were compared using t-test and p greater or equal to 0.05 was considered significant. Results: In control group, the ulnar FWML was either equal or slightly longer that the median FWML value. In CTS group with type II diabetes mellitus the FWML value of median nerve were significantly longer than FWML of the ulnar nerve. Moreover, in uncontrolled diabetic patients the FWML values was very much longer than controlled group. Similarly the F-ratio of median nerve was significantly low. Conclusion: In addition to the specific criteria for CTS diagnosis, the parameters like FWML difference in median and ulnar nerve with reduced F-ratio of median nerve can be useful in establishing the diagnosis and severity of CTS in type II diabetes mellitus. (author)

  14. Impact of autologous hematopoietic stem cell transplantation on the quality of life of type 1 diabetes mellitus patients Impacto do transplante de células-tronco hematopoéticas sobre a qualidade de vida de pacientes com diabetes mellitus tipo 1

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    Manoel Antônio dos Santos

    2011-01-01

    Full Text Available The present study aimed at assessing the health-related quality of life (HRQoL of patients with type 1 diabetes mellitus (DM1 submitted to autologous hematopoietic stem cell transplantation (HSCT. This study is part of a pioneering research protocol which tests the applicability of autologous hematopoietic stem cell transplantation as a new therapeutic approach to DM1. The study was conducted on 14 patients admitted to the ward of the Bone Marrow Transplantation Unit of a university hospital during the period from October 2006 to December 2007. The patients were evaluated at admission and on the occasion of the ambulatory return visit 100 days after transplantation. They answered the SF-36 quality of life questionnaire and the data were analyzed according to literature recommendations. The results showed that 100 days after transplantation the value of the patients' quality of life was higher compared to the pre-HSCT value, with significant differences in the Physical Domains (Role Limitations due to Physical Problems (p = .009, Vitality (p = .02 and Mental Health (p = .04, demonstrating significant appreciation of those domains after the procedure. The results indicate an improvement in HRQoL after HSCT. The SF-36 proved to be a useful instrument for the assessment of quality of life in patients with DM1 submitted to HSCT.Este estudo teve como objetivo avaliar a qualidade de vida relacionada à saúde (QVRS de pacientes com diabetes mellitus tipo 1 (DM1 submetidos ao Transplante de Células-Tronco Hematopoéticas (TCTH. O estudo é parte de um protocolo de pesquisa pioneiro no mundo, que testa a aplicabilidade do TCTH como nova abordagem terapêutica no DM1. Foram investigados 14 pacientes, que constituíram a população de pessoas internadas na enfermaria da Unidade de Transplante de Medula Óssea de um hospital universitário, no período de outubro de 2006 a dezembro de 2007. Os pacientes foram avaliados na admissão e no retorno

  15. ANÁLISE DAS DIFICULDADES RELACIONADAS ÀS ATIVIDADES DIÁRIAS DE CRIANÇAS E ADOLESCENTE COM DIABETES MELLITUS TIPO 1: DEPOIMENTO DE MÃES ANÁLISIS DE LAS DIFICULTADES RELACIONADAS CON LAS ACTIVIDADES DIARIAS DE LOS NIÑOS Y ADOLESCENTES CON DIABETES MELLITUS TIPO 1: DECLARACIONES DE LAS MADRES ANALYSIS OF DIFFICULTIES REGARDING THE DAILY ACTIVITIES OF TEENAGERS AND CHILDREN WITH TYPE-1 DIABETES MELLITUS: MOTHERS' ACCOUNTS

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    Maria Lúcia Zanetti

    2001-11-01

    Full Text Available Estudo descritivo com o objetivo de analisar as dificuldades que as mães de crianças e adolescentes diabéticos tipo 1 apresentam face as atividades diárias com o filho, partindo da premissa de que fatores de ordem econômica, social, pessoal e emocional da família interferem para obtenção de um bom controle metabólico. Através de roteiro semi-estruturado de entrevista aplicado a trinta mães, obteve-se os dados cuja análise obedeceu às normas preconizadas para estudos descritivos. Os resultados permitiram concluir que as mães apontaram como dificuldades nas atividades diárias com os filhos: reuniões de convivência social; motivá-lo a realizar atividade física; dieta; adaptação escolar; relacionamento com a equipe de saúde e comportamento do filho frente aos demais irmãos. Foi evidenciada a necessidade de trabalho planejado e integrado por equipe multiprofissional junto às famílias, direcionado para cada dificuldade abordada, observando-se sua interdependência para o êxito do cuidado à criança e adolescente diabético tipo 1.Estudio descriptivo con el objetivo de analizar las dificultades que las madres de los niños y adolescentes diabéticos tipo 1, presentan de cara a las actividades diarias con el hijo; partiendo de la premisa de que factores de orden económico, social, personal y emocional de la familia interfieren para la obtención de un buen control metabólico. A través de un guión de entrevista semi-estructurada aplicado a treinta madres, se obtuvieron los datos, cuyo análisis se realizó según las normas preconizadas para estudios descriptivos. Los resultados permitieron concluir que las madres anotan como dificultades en las actividades diarias con los hijos: reuniones de convivencia social, motivarlo a realizar la actividad física, dieta, adaptación escolar, relación con el equipo de salud y el comportamiento del hijo frente a los demás hermanos. Se hizo evidente la necesidad de un trabajo planeado

  16. Value of urinary trace proteins in evaluating kidney function in the course of diabetes mellitus II rehabilitation%尿微量蛋白检测在 2型糖尿病中评估肾功能的价值

    Institute of Scientific and Technical Information of China (English)

    陈宝平; 宋新瑞

    2001-01-01

    Objective To discuss the value of urinary trace proteins in evaluating kidney function in the course of diabetes mellitus II rehabilitation.Method To assay level of urinary trace proteins in 50 cases of diabetes mellitus II and healthy control subjects. Result Level of trace proteins in 40 cases with diabetes mellitus ranged between normal values.They showed significantly increased urinary trace proteins(80% ).Conclusion Urinary trace proteins is a sensible indicator for evaluating kidney function in diabetes mellitus II.

  17. Atividade da enzima acetil-hidrolase do fator ativador de plaquetas (PAF-AH em pacientes com diabete melito tipo 1 Platelet-activating factor acetylhydrolase (PAF-AH activity in patients with type 1 diabetes mellitus

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    Simone Henriques de Castro

    2007-02-01

    Full Text Available OBJETIVO: Avaliar a atividade da acetil-hidrolase do fator ativador de plaquetas (PAF-AH e sua relação com variáveis clinicodemográficas, com o controle metabólico, os níveis de apolipoproteínas A e B e a suscetibilidade da lipoproteína de baixa densidade (LDL à oxidação in vitro em pacientes com DM tipo 1 (DM 1. MÉTODOS: Foram avaliados 42 pacientes com DM1 (27 mulheres e 48 não-diabéticos (16 mulheres, pareados por sexo, idade e índice de massa corporal (IMC. Os exames realizados foram: glicemia de jejum (GJ e pós-prandial (GPP, lipidograma, ácido úrico (AU, hemoglobina glicosilada (HbA1c e coeficiente de oxidação da lipoproteína de baixa densidade (LDL por espectrofotometria. A análise da atividade da PAF-AH foi realizada por espectrofotometria (Cayman Chemical. RESULTADOS: A análise da atividade da PAF-AH mostrou haver maior atividade enzimática nos pacientes com DM 1 do que nos não-diabéticos (0,0150 ± 0,0051 versus 0,0116 ± 0,0041; p OBJECTIVE: To evaluate platelet-activating factor acetylhydrolase (PAF-AH activity and its relationship with clinical and demographic variables, metabolic control, apolipoprotein A and B levels and the susceptibility of low-density lipoprotein (LDL to in vitro oxidation in patients with type 1 diabetes mellitus (DM 1. METHODS: Forty two patients with DM 1 (27 females and 48 control subjects (16 females matched for gender, age and body mass index (BMI were evaluated. The following tests were performed: fast plasma glucose (FG and postprandial plasma glucose (PPG, lipid profile, uric acid (UA, glycosylated hemoglobin (HbA1c, and low-density lipoprotein (LDL oxidation rate using colorimetric assay. The PAF-AH activity was analyzed using colorimetric assay (Cayman Chemical. RESULTS: The analysis of PAF-AH activity showed a higher enzyme activity in patients with DM 1 than in control subjects (0.0150 ± 0.0051 vs. 0.0116 ± 0.0041; p < 0.001. In patients with DM 1, a direct correlation

  18. The imaging manifestations of caseous pulmonary tuberculosis with type-II diabetes mellitus

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    Mingyue Wang

    2015-11-01

    Conclusion: Type-II diabetic patients with caseous tuberculosis mainly showed consolidation and atypical lung field lesions on chest radiographs. Becoming familiar with these features will be helpful to imaging diagnosis of DMTB.

  19. Education and technology used to improve the quality of life for people with diabetes mellitus type II

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    Dudley B

    2014-03-01

    Full Text Available Brooke Dudley, Brianne Heiland, Elizabeth Kohler-Rausch, Mark Kovic Midwestern University Occupational Therapy Program, Downers Grove, IL, USA Background: The incidence of type II diabetes mellitus (DMT2 is expected to continue to rise. Current research has analyzed various tools, strategies, programs, barriers, and support in regards to the self-management of this condition. However, past researchers have yet to analyze the education process; including the adaptation of specific strategies in activities of daily living and roles, as well as the influence of health care providers in the integration of these strategies. Objectives: The purpose of this qualitative case study was to identify the strengths and limitations of the current model of diabetes education in the United States and hypothesize how technology can impact quality of life. Methods: Key informants on diabetes education were recruited from diabetes education centers through the American Association of Diabetes Educators. Semi-structured interviews were conducted with participants. Results: Health care practitioners convey limited knowledge of DMT2. Individuals with DMT2 often have limited understanding of the implications of poor self-management. There appears to be no consistent standard of care for how to effectively incorporate self-management strategies. There is limited education for the use of technology in self-management. Diabetes educators describe that technology could be beneficial. Conclusion: Findings suggest the importance of the role of care providers in emphasizing the implications of poor self-management strategies; that a multidisciplinary approach may enhance the education process; and a need for further developments in technology to address DMT2 self-management strategies. Keywords: health promotion, quality of life, diabetes mellitus type 2, technology, health education

  20. Insulin therapy refusal among type II diabetes mellitus patients in Kubang Pasu district, the state of Kedah, Malaysia.

    Science.gov (United States)

    Tan, Wei Leong; Asahar, Siti Fairus; Harun, Noor Liani

    2015-04-01

    Diabetes mellitus is a rising non-communicable disease in Malaysia. Insulin therapy refusal is a great challenge for healthcare providers, as it results in delayed insulin initiation. This study was conducted to determine the prevalence of insulin therapy refusal and its associated factors. This cross sectional study was conducted at seven public health clinics in Kubang Pasu district, Malaysia, from March to October 2012. A newly developed and validated questionnaire was used and participants were selected via systematic random sampling. Only patients diagnosed with type II diabetes mellitus (T2DM) and under the public health clinic care in Kubang Pasu were included in the study. Multiple logistic regressions were used to study the association between insulin therapy refusal and its associated factors. There were 461 respondents and the response rate was 100%. Among these 461 patients with T2DM, 74.2% refused insulin therapy. The most common reason given for refusal was a lack of confidence in insulin injection (85.4%). Multiple logistic regression revealed that respondents who had secondary education were 55.0% less likely to refuse insulin therapy than those who had primary or no formal education (p = 0.009, adjusted odds ratio [OR] = 0.45, 95% confidence interval [CI] = 0.25-0.82). There was also a significant inverse association between glycated haemoglobin (HbA1c) and insulin therapy refusal (p = 0.047, adjusted OR = 0.87, 95% CI = 0.76-1.00). Insulin therapy refusal is common in Kubang Pasu. Education status and HbA1c should be taken into consideration when counselling patients on insulin therapy initiation.

  1. CLINICAL PROFILE OF PATTERN OF DYSLIPIDAEMIA AND ISCHAEMIC HEART DISEASE IN TYPE II DIABETES MELLITUS PATIENTS

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    Atul Vijayrao Rajkondawar

    2017-07-01

    Full Text Available BACKGROUND The present research was undertaken to study the pattern of dyslipidaemia and varied clinical manifestations of ischaemic heart disease, its risk factors in type 2 diabetes mellitus patients. Diabetes Mellitus (DM has become major public health problem in India. It is not only increasing in morbidity and mortality, but also decreases the quality of life. Also, disease and its complications are causing heavy economic burden for patients suffering from it.1,2 Diabetes is endemic globally with increasing prevalence in both developing and developed countries. Diabetes is a major cause of mortality, but several studies indicate that it is likely underreported as a cause of death. A recent estimate suggested that diabetes was the fifth leading cause of death worldwide and was responsible for almost 3 million deaths annually (1.7-5.2% of all deaths. MATERIALS AND METHODS A total of 100 patients attending the outpatient department or admitted to medical wards, ICU of tertiary care centre and fulfilling the inclusion criteria were evaluated clinically. A baseline Electrocardiogram (ECG was taken in all cases irrespective of clinical evidence of cardiac involvement. Patients with normal ECG pattern were further evaluated by Treadmill Testing (TMT or stress test for subclinical cardiac involvement. Risk factor evaluation was done in all cases. RESULTS Prevalence of IHD was found to be 41% with a male predominance (1.067:1. Evaluation of risk factors has shown its strong association with IHD. Incidence of IHD was high when low HDL (P 25 had negatively significant association with IHD in type 2 diabetics (P=0.072. Smoking was not statistically associated (P=0.577 and in male alcoholics, IHD had positive association with alcohol (P=0.193. CONCLUSION The current study points out that there exists an increased incidence of ischaemic heart disease in diabetics with few, but not all risk factors contributing to it. Early detection, optimal glycaemic

  2. Corneal endothelial morphology and central thickness in patients with type II diabetes mellitus

    DEFF Research Database (Denmark)

    Storr-Paulsen, Allan; Singh, Amardeep; Jeppesen, Helene

    2014-01-01

    size was based on a power calculation (power = 0.90; p = 0.05). The diabetic patients had on average more than four HbA1c tests performed (mean 4.1; range 2-14) with intervals of at least 3 months as a reflection of the long-term glycaemic status. The controls had no diabetes confirmed by two causal......PURPOSE: To investigate corneal endothelial cell density and morphology in type II diabetic and non-diabetic patients and to relate potential differences to the glycaemic status. METHODS: A prospective clinical study including 107 patients with type II diabetes and 128 non-diabetic patients. Sample...... blood tests. The endothelial cell density, the variation in endothelial cell size (CV), the percentage of hexagonal cells, and the central corneal thickness (CCT) were recorded. RESULTS: Type II diabetic subjects did not differ from the non-diabetic control subjects with regards to endothelial cell...

  3. ORAL HYPOGLYCAEMIC AGENTS IN THE MANAGEMENT OF TYPE II DIABETES MELLITUS

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    Durgaprasad M.

    2016-06-01

    Full Text Available OBJECTIVES Diabetes is fast gaining the status of a potential epidemic globally. The number of people with diabetes has risen from 108 million in 1980 to 422 million in 2014, the rise seen more rapidly in developing and under developed countries. Type 2 Diabetes Mellitus (T2DM being the most common type, accounting for an estimated 85-95% of all diabetes cases. Diabetes remains a major cause of blindness, renal failure, and cardiovascular events including heart attacks, stroke and limb amputations. 1 Being an heterogeneous disorder, many adults with T2DM have difficulty controlling their blood sugar levels and associated complications as most of available antidiabetic agents aim to achieve only normoglycaemia and relieve diabetes symptoms, such as polydipsia, polyuria, weight loss, ketoacidosis while the longterm goals to prevent the development of or slow the progression of longterm complications of the disease is often unaddressed, therefore, there remains, a significant unmet demand for new agents that will help diabetic patients achieve treatment targets without increasing the risk for weight gain or hypoglycaemia. Among the new classes of oral agents, SGLT-2 inhibitors and mTOT insulin sensitisers appear to hold some good promise. However, recent articles published describing its adverse effect profile of SGLT-2 inhibitors had put a question mark on its utility. In this article, we have reviewed the plethora of available OHAs along with the newer OHAs for managing T2DM optimally.

  4. Role of blink reflex in diagnosis of subclinical cranial neuropathy in diabetic mellitus type II.

    Science.gov (United States)

    Kazem, Shakouri S; Behzad, Davoudi

    2006-05-01

    Peripheral neuropathy (PN) is one of the late complications of diabetes mellitus. Cranial nerves III, VII, and V are among the most commonly affected in diabetic patients. Traditional electrodiagnosis (Edx) studies are a useful method for diagnosis of PN and symptomatic cranial neuropathy, and may not be useful for detecting subclinical involvement of cranial nerves. The main objective of this study is to evaluate the role of blink reflex (BR) for early diagnosis of cranial neuropathy in diabetic patients with PN. A prospective study was performed on NIDDM patients with PN. One hundred eighty-eight subjects were included in our study in which 142 acted as healthy subjects and 46 as diabetic patients. Patients were excluded with prior history of cranial nerve lesions, stroke, or any other disease with polyneuropathy or drug-induced neuropathy. Routine nerve conduction studies were performed, and only patients with PN were included in this study. Abnormalities were found in 54.4% of patients. R1, IR2, and CR2 were prolonged relative to the healthy group. Statistically there was no significant difference in R/D ratio of patients (P=0.201). Also, there was a positive correlation between R1, IR2, and CR2 latencies with duration of diabetes and severity of polyneuropathy, but not for R/D. The greatest correlation was shown in R1 latency (69.9% abnormality). BR is a noninvasive and very useful method for the evaluation and diagnosis of subclinical cranial nerve involvement in diabetic patients.

  5. O polimorfismo A1166C do receptor tipo 1 da angiotensina II no infarto agudo do miocárdio The A1166C polymorphism of the angiotensin II type-1 receptor in acute myocardial infarction

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    Messias Antônio de Araújo

    2004-11-01

    Full Text Available RESUMO OBJETIVO:Avaliar a associação do polimorfismo A1166C do gene do receptor AT1 da angiotensina II (AT1R com o infarto agudo do miocárdio e a severidade da doença arterial coronariana. MÉTODOS: Estudo prospectivo, transversal de 110 pacientes com infarto agudo do miocárdio submetidos à angiografia coronariana com lesão significante (> 50% avaliada por três critérios de severidade: número de vasos lesados, morfologia da placa aterosclerótica e escore de risco coronariano. Sem lesões coronarianas 104 indivíduos controles. O polimorfismo A1166C do gene do AT1R foi determinado pela reação em cadeia da polimerase no DNA dos leucócitos do sangue periférico. Os fatores de risco coronariano clássicos foram analisados em todos os indivíduos. RESULTADOS: Na estratificação dos genótipos em relação aos fatores de risco apenas o tabagismo teve predominância nos heterozigotos AC (p = 0,02. A freqüência dos genótipos nos pacientes infartados foi de AA = 54,5%; AC = 35,5% e CC = 10%, sendo similar e não significativa em relação aos controles (p = 0,83. Não houve aumento do risco de infarto agudo do miocárdio nas comparações dos genótipos CC vs AA (OR = 1,35; IC-95% = 0,50 - 3,59, AC vs AA (OR = 1,03; IC-95% = 0,58 - 1,84 e AA+AC vs AA (OR = 1,33; IC-95% = 0,51 - 3,45. Nenhum dos critérios de severidade teve associação significativa com os genótipos. CONCLUSÃO: Os nossos resultados indicam não haver associação do polimorfismo A1166C do AT1R com o infarto agudo do miocárdio e nem com a severidade da doença arterial coronariana segundo nossos resultados.OBJECTIVE: To assess the association of the A1166C polymorphism of the angiotensin II type-1 receptor (AT1R gene with acute myocardial infarction and also with the severity of coronary artery disease. METHODS: A prospective, cross-sectional study was carried out with 110 patients with acute myocardial infarction, who, on coronary angiography, had significant

  6. Salivary glucose as a diagnostic tool in Type II diabetes mellitus: A ...

    African Journals Online (AJOL)

    2015-11-02

    Nov 2, 2015 ... glucose level is the key to both diagnosis and management of ... diagnostic, as well as a monitoring tool to assess the glycemic status of Type II ..... Priya SS, Bharani GO, Nagalingam M, Jayanthi M, Kanagavalli U. Potential of ... Agrawal RP, Sharma N, Rathore MS, Gupta VB, Jain S, Agarwal V, et al.

  7. A Systematic Review: Family Support Integrated with Diabetes Self-Management among Uncontrolled Type II Diabetes Mellitus Patients

    OpenAIRE

    Pamungkas, Rian Adi; Chamroonsawasdi, Kanittha; Vatanasomboon, Paranee

    2017-01-01

    The rate of type-2 diabetes mellitus (T2D) is dramatically increasing worldwide. Continuing diabetes mellitus (DM) care needs effective self-management education and support for both patients and family members. This study aimed to review and describe the impacts of diabetes mellitus self-management education (DSME) that involve family members on patient outcomes related to patient health behaviors and perceived self-efficacy on self-management such as medication adherence, blood glucose moni...

  8. The effect of xerostomia and hyposalivation on the quality of life of patients with type II diabetes mellitus

    OpenAIRE

    Molania, Tahereh; Alimohammadi, Mona; Akha, Ozra; Mousavi, Jaber; Razvini, Ramin; Salehi, Maedeh

    2017-01-01

    Background Diabetes mellitus is a chronic metabolic disease which can have numerous physical effects for patient. Xerostomia is one of these complications. Compared to healthy people, patients with diabetes mellitus, have a worse quality of life, and complications of diabetes are the main determinants of quality of life in these patients. Objective The aim of this study was to determine the effects of xerostomia and hyposalivation on quality of life of patients with type 2 diabetes mellitus. ...

  9. 26. Effectiveness of telephone follow up in managing patients with type II diabetes mellitus

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    Ala Taiyem

    2015-10-01

    Full Text Available Diabetes mellitus is one of the most common non-communicable diseases globally, labeled as the greatest healthcare challenge according to the World Health Organization and the International Diabetes Federation. This complex disease requires the involvement of multidisciplinary teams to reduce the risk and impact of long-term diabetes complications through intensive monitoring, education and lifestyle modifications with a great emphasis on promoting self-care. A brief and cost-effective interventions to improve diabetes self care management are needed. This study evaluated the effect of “educational” telephone intervention delivered by nurse specialist on glycemic control “Glyclated hemoglobin A1c”, and diabetes self-care management for patients with type 2 diabetes followed-up by a nurse-led cardiovascular disease management program of a tertiary hospital within the Kingdom of Saudi Arabia. This quantitative descriptive and qauzi-experimental study was conducted over three months, included 60 adult patients diagnosed with type 2 diabetes who were randomly assigned to intervention or control group. Participants within the intervention group received usual care and six educational phone calls promoting them to improve their diabetic self-care activities. Patients within the control arm continued to receive their usual care only. The telephone follow-up intervention increased frequency of exercise and foot care, improved diet and adherence to anti-diabetes medication. Modest improvement was detected on the glycemic control and home glucose monitoring. As a conclusion, the study indicated positive effect of the intervention on glycemic control and self-care management. Multi-centers and longitudinal studies with larger sample size are recommended for future studies.

  10. [COMPARISON OF INTRAOPERATIVE SCLEROOBLITERATION AND ECHOSCLEROOBLITERATION EFFICIENCY OF VARICOSE DISEASES OF THE LOWER EXTREMITIES C6 CLASS IN PATIENTS BY TYPE II DIABETES MELLITUS].

    Science.gov (United States)

    Palamarchuk, V I; Odnorog, S I; Gvozdyak, M M; Vilgash, A M

    2015-06-01

    The experience of surgical treatment of 50 patients for varicose disease of lower extremities, complicated by trophic ulcers, in the presence of diabetes mellitus type II were analysed. During surgery in patients of the 1st group performed a combined phlebectomy, group 2--scleroobliteration and echoscleroobliteration. Using fleboscleroobliteration method helped reduce the frequency of early postoperative complications in (6.5 +/- 1.3) times.

  11. Coronary Heart Disease in Postmenopausal Women with Type II Diabetes Mellitus and the Impact of Estrogen Replacement Therapy: A Narrative Review

    OpenAIRE

    Marouane Boukhris; Salvatore Davide Tomasello; Francesco Marzà; Sonia Bregante; Francesca Romana Pluchinotta; Alfredo Ruggero Galassi

    2014-01-01

    Coronary heart disease is the main cause of death in postmenopausal women (PMW); moreover its mortality exceeds those for breast cancer in women at all ages. Type II diabetes mellitus is a major cardiovascular risk factor and there is some evidence that the risk conferred by diabetes is greater in women than in men. It was established that the deficiency of endogenous estrogens promotes the atherosclerosis process. However, the impact of estrogen replacement therapy (ERT) on cardiovascular pr...

  12. Cost-effectiveness of Bariatric Surgery: Increasing the Economic Viability of the Most Effective Treatment for Type II Diabetes Mellitus.

    Science.gov (United States)

    Warren, Jeremy A; Ewing, Joseph A; Hale, Allyson L; Blackhurst, Dawn W; Bour, Eric S; Scott, John D

    2015-08-01

    There has been considerable debate on the cost-effectiveness of bariatric surgery within larger population groups. Despite the recognition that morbid obesity and its comorbidities are best treated surgically, insurance coverage is not universally available. One of the more costly comorbidities of obesity is Type II diabetes mellitus (T2DM). We propose a model that demonstrates the cost-effectiveness of increasing the number of bariatric surgical operations performed on patients with T2DM in the United States. We applied published population cost estimates (2012) for medical care of T2DM to a retrospective cohort of morbidly obese patients in South Carolina. We compared differences in 10-year medical costs between those having bariatric surgery and controls. Resolution of T2DM in the bariatric cohort was assumed to be 40 per cent. Considering only the direct medical costs of T2DM, the 10-year aggregate cost savings compared with a control group is $2.7 million/1000 patients; the total (direct and indirect) cost savings is $5.4 million/1000 patients. When considering resolution of T2DM alone, increasing the number of bariatric operations for a given population leads to a substantial cost savings over a 10-year period. This study adds to the growing body of evidence suggesting that bariatric surgery is a cost-effective means of caring for the obese patient.

  13. Downregulation of Type II Diabetes Mellitus and Maturity Onset Diabetes of Young Pathways in Human Pancreatic Islets from Hyperglycemic Donors

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    Jalal Taneera

    2014-01-01

    Full Text Available Although several molecular pathways have been linked to type 2 diabetes (T2D pathogenesis, it is uncertain which pathway has the most implication on the disease. Changes in the expression of an entire pathway might be more important for disease pathogenesis than changes in the expression of individual genes. To identify the molecular alterations in T2D, DNA microarrays of human pancreatic islets from donors with hyperglycemia n=20 and normoglycemia n=58 were subjected to Gene Set Enrichment Analysis (GSEA. About 178 KEGG pathways were investigated for gene expression changes between hyperglycemic donors compared to normoglycemic. Pathway enrichment analysis showed that type II diabetes mellitus (T2DM and maturity onset diabetes of the young (MODY pathways are downregulated in hyperglycemic donors, while proteasome and spliceosome pathways are upregulated. The mean centroid of gene expression of T2DM and MODY pathways was shown to be associated positively with insulin secretion and negatively with HbA1c level. To conclude, downregulation of T2DM and MODY pathways is involved in islet function and might be involved in T2D. Also, the study demonstrates that gene expression profiles from pancreatic islets can reveal some of the biological processes related to regulation of glucose hemostats and diabetes pathogenesis.

  14. Preventive Effect of Boiogito on Metabolic Disorders in the TSOD Mouse, a Model of Spontaneous Obese Type II Diabetes Mellitus

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    Tsutomu Shimada

    2011-01-01

    Full Text Available “Boiogito” is a Kampo preparation which has been used since ancient times in patients with obesity of the “asthenic constitution” type, so-called “watery obesity”, and its effect has been recognized clinically. In this study, we investigated the anti-obesity effect of Boiogito in the TSOD (Tsumura Suzuki Obese Diabetes mouse, a model of spontaneous obese type II diabetes mellitus. Boiogito showed a significant anti-obesity effect in TSOD mice by suppressing body weight gain in a dosage-dependent manner. In addition, Boiogito showed significant ameliorative effects on features of metabolic syndrome such as hyperinsulinemia, fasting hyperglycemia and abnormal lipid metabolism. Regarding lipid accumulation in TSOD mice, Boiogito showed a significant suppressive effect on accumulation of subcutaneous fat, but the effect on the visceral fat accumulation that constitutes the basis of metabolic syndrome was weak, and the suppressive effect on insulin resistance was also weak. Furthermore, Boiogito did not alleviate the abnormal glucose tolerance, the hypertension or the peripheral neuropathy characteristically developed in the TSOD mice. In contrast, in the TSNO (Tsumura Suzuki Non-Obesity mice used as controls, Boiogito suppressed body weight gain and accumulation of subcutaneous and visceral fat. The above results suggested that Boiogito is effective as an anti-obesity drug against obesity of the “asthenic constitution” type in which subcutaneous fat accumulates, but cannot be expected to exert a preventive effect against various symptoms of metabolic syndrome that are based on visceral fat accumulation.

  15. Education and technology used to improve the quality of life for people with diabetes mellitus type II.

    Science.gov (United States)

    Dudley, Brooke; Heiland, Brianne; Kohler-Rausch, Elizabeth; Kovic, Mark

    2014-01-01

    The incidence of type II diabetes mellitus (DMT2) is expected to continue to rise. Current research has analyzed various tools, strategies, programs, barriers, and support in regards to the self-management of this condition. However, past researchers have yet to analyze the education process; including the adaptation of specific strategies in activities of daily living and roles, as well as the influence of health care providers in the integration of these strategies. The purpose of this qualitative case study was to identify the strengths and limitations of the current model of diabetes education in the United States and hypothesize how technology can impact quality of life. Key informants on diabetes education were recruited from diabetes education centers through the American Association of Diabetes Educators. Semi-structured interviews were conducted with participants. Health care practitioners convey limited knowledge of DMT2. Individuals with DMT2 often have limited understanding of the implications of poor self-management. There appears to be no consistent standard of care for how to effectively incorporate self-management strategies. There is limited education for the use of technology in self-management. Diabetes educators describe that technology could be beneficial. Findings suggest the importance of the role of care providers in emphasizing the implications of poor self-management strategies; that a multidisciplinary approach may enhance the education process; and a need for further developments in technology to address DMT2 self-management strategies.

  16. Frecuencia de la hipertensión arterial y su relación con algunas variables clínicas en pacientes con diabetes mellitus tipo 2 High blood pressure frequency and its relation to some clinical variables in patients diagnosed with type 2 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Eduardo Valdés Ramos

    2009-12-01

    Full Text Available Se realizó un estudio descriptivo transversal con 300 pacientes diabéticos tipo 2 ingresados en el Centro de Atención al Diabético de Bayamo, Granma, en el período comprendido entre octubre de 2007 y mayo de 2008, con el objetivo de conocer la frecuencia de hipertensión arterial y su relación con algunas variables clínicas en estos casos. Se revisaron las historias clínicas de cada uno de ellos para obtener datos de los aspectos siguientes: edad, sexo, color de la piel, hábitos tóxicos, edad al comienzo de la diabetes, estado nutricional, circunferencia de la cintura, tensión arterial y complicaciones crónicas de la diabetes. Se encontró hipertensión arterial en 210 pacientes (70 %; de ellos, 57 (27,1 % presentaron hipertensión sistólica aislada, 39 (18,5 % hipertensión diastólica, y 114 (54,4 % hipertensión sistodiastólica. La hipertensión arterial se presentó desde el inicio de la diabetes en el 62,9 %. El 76,1 % de los pacientes hipertensos tenían sobrepeso u obesidad (P=0,0557. Resultó significativa la asociación entre la hipertensión arterial y la cardiopatía isquémica (p= 0,0117. En relación con el ictus y la insuficiencia arterial periférica, aunque la mayoría de los casos eran hipertensos, no llegó a ser estadísticamente significativo (p= 0,8261, p= 0,8600. El 71,1 % de los pacientes con retinopatía diabética y el 75 % con nefropatía diabética eran hipertensos (p= 0,8261, p= 0,8600. Se concluye que la hipertensión arterial tiene una elevada incidencia en los pacientes con diabetes mellitas tipo 2, porque está presente en un porcentaje importante desde el diagnóstico de la diabetes y se asocia significativamente a la presencia de cardiopatía isquémica.A cross-sectional and descriptive study was conducted in 300 patients with type 2 diabetes admitted in Diabetes Care Center of Bayamo, Granma province between October, 2007 and May, 2008 to know the high blood pressure frequency and its relation to

  17. Tratamento da artrose unicompartimental medial do joelho com artroplastia unicompartimental tipo Repicci II: relato preliminar de 42 casos Treatment of medial unicompartmental arthrosis of the knee with Repicci II unicompartmental arthroplasty: preliminary report of 42 cases

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Sanches Vaz

    2008-04-01

    Full Text Available OBJETIVO: Relatar a evolução de pacientes com artrose unicompartimental medial do joelho submetidos à artroplastia unicompartimental tipo Repicci II, com o propósito de avaliar a validade do procedimento. MÉTODOS: Participaram do estudo 36 pacientes com artrose unicompartimental do joelho, seis dos quais apresentavam acometimento bilateral, totalizando 42 joelhos. A idade variou de 54 a 82 anos, com média de 67 anos. Trinta e dois pacientes eram do sexo feminino e 10 do masculino. Os critérios clínicos de seleção foram: pacientes acima dos 50 anos de idade, nível de atividade leve/moderado, amplitude articular de pelo menos 90º de flexão e -10º de extensão, deformidade em varo menor ou igual a 5º, ausência de instabilidade ligamentar anterior e dor restrita ao compartimento medial. Os critérios radiográficos foram: artrose confinada ao compartimento medial com ausência ou mínima artrose patelofemoral. Utilizou-se a classificação de Ahlbäck para quantificar o grau de extensão da artrose, indicando-se cirurgia nos graus II, III e IV. Para acompanhamento dos resultados, utilizou-se a escala da Knee International Society. RESULTADOS: O tempo médio de seguimento foi de 36 meses. Não ocorreram casos de infecção pós-operatória, trombose venosa profunda ou embolia. Dois pacientes evoluíram com dor importante sem melhora com acompanhamento clínico, sendo necessária a revisão com prótese total do joelho. Não foram observados casos de soltura asséptica, afundamento do componente tibial ou desgaste precoce do polietileno. O escore médio pré-operatório foi de 45 para o joelho e de 57 para a função global do paciente. O escore pós-operatório foi de, respectivamente, 76 e 90 pontos. CONCLUSÃO: A artroplastia unicompartimental tipo Repicci II é uma boa opção no tratamento da artrose unicompartimental medial do joelho, trazendo resultados consistentes e implicando alto nível de satisfação dos pacientes, desde

  18. Costos directos de atención médica en pacientes con diabetes mellitus tipo 2 en México: análisis de microcosteo Direct costs of medical care for patients with type 2 diabetes mellitus in Mexico micro-costing analysis

    Directory of Open Access Journals (Sweden)

    Rosibel de los Ángeles Rodríguez Bolaños

    2010-12-01

    Full Text Available OBJETIVO: Estimar los costos directos de la atención médica a pacientes con diabetes mellitus tipo 2 (DM2 en el Instituto Mexicano del Seguro Social (IMSS. MÉTODOS: Se revisaron expedientes clínicos de 497 pacientes que ingresaron a unidades de segundo y tercer nivel de atención durante el período 2002-2004. Los costos se cuantificaron utilizando el enfoque de costeo de enfermedad (CDE desde la perspectiva del proveedor, la técnica del microcosteo y la metodología de abajo-arriba (bottom-up. Se estimaron costos promedio anuales de diagnóstico, por complicación y total de la enfermedad. RESULTADOS: El costo total anual de los pacientes con DM2 para el IMSS fue de US$452 064 988, correspondiente a 3,1% del gasto de operación. El costo promedio anual por paciente fue de US$3 193,75, correspondiendo US$2 740,34 para el paciente sin complicaciones y US$3 550,17 para el paciente con complicaciones. Los días/cama en hospitalización y en unidad de cuidados intensivos fueron los servicios con mayor costo. CONCLUSIONES: Los elevados costos en la atención médica a pacientes con DM2 y complicaciones representan una carga económica que las instituciones de salud deben considerar en su presupuesto, a fin de poder brindar un servicio de calidad, adecuado y oportuno. El empleo de la metodología de microcosteo permite un acercamiento a datos reales de utilización y manejo de la enfermedadOBJECTIVE: Estimate the direct cost of medical care incurred by the Mexican Social Security Institute (IMSS, Instituto Mexicano del Seguro Social for patients with type 2 diabetes mellitus (DM2. METHODS: The clinical files of 497 patients who were treated in secondary and tertiary medical care units in 2002-2004 were reviewed. Costs were quantified using a disease costing approach (DCA from the provider's perspective, a micro-costing technique, and a bottom-up methodology. Average annual costs by diagnosis, complication, and total cost were estimated. RESULTS

  19. Control of type 2 diabetes mellitus among general practitioners in private practice in nine countries of Latin America Control de la diabetes mellitus tipo 2 por médicos generales del sector privado en nueve países de América Latina

    Directory of Open Access Journals (Sweden)

    Gloria Lopez Stewart

    2007-07-01

    édicos generales del sector privado la información sobre la atención y el control de sus pacientes de 18 a 75 años de edad con diabetes mellitus tipo 2 (DMT2, así como los datos demográficos, la historia clínica y de medicación, las pruebas de laboratorio e información sobre los retos relacionados con la atención del paciente. RESULTADOS: De los 3 592 cuestionarios de pacientes entregados por 377 médicos, 60% de los pacientes tenían antecedentes familiares de diabetes, 58% seguían una dieta inadecuada, 71% eran sedentarios y 79% presentaban obesidad o sobrepeso. Se observó un inadecuado control glucémico (glucemia en ayunas > 110 mg/dL en 78% de los pacientes. La proporción de pacientes con HbA1c 15 años. Tomado en cuenta las diferencias entre la atención sanitaria privada y la pública en América Latina, especialmente en lo concerniente a la calidad de la atención y el acceso a los medicamentos, se requieren estudios adicionales en el sector público. En general, se necesita un programa más eficiente e intensivo de control de la DMT2 y programas eficaces de educación de los pacientes, ajustados a las realidades de América Latina.

  20. Custo-efetividade e impacto orçamentário da saxagliptina como terapia adicional à metformina para o tratamento do diabetes mellitus tipo 2 no sistema de saúde suplementar do Brasil Cost-effectiveness and budget impact of saxagliptine as additional therapy to metformin for the treatment of diabetes mellitus type 2 in the brazilian private health system

    Directory of Open Access Journals (Sweden)

    Marcelo Eidi Nita

    2012-06-01

    Full Text Available OBJETIVOS: Comparar custos e benefícios clínicos de três terapias adicionais à metformina (MF para pacientes com diabetes mellitus tipo 2 (DMT2. MÉTODOS: Um modelo de simulação de eventos discretos foi construído para estimar a relação custo-utilidade (custo por QALY da saxagliptina como uma terapia adicional à MF comparada à rosiglitazona ou pioglitazona. Um modelo de impacto orçamentário (BIM - Budget Impact Model foi construído para simular o impacto econômico da adoção de saxagliptina no contexto do Sistema Suplementar de Saúde brasileiro. RESULTADOS: O custo de aquisição da medicação para o grupo de pacientes hipotéticos analisados, para o horizonte temporal de três anos, foi de R$ 10.850.185,00, R$ 14.836.265,00 e R$ 14.679.099,00 para saxagliptina, pioglitazona e rosiglitazona, respectivamente. Saxagliptina exibiu menores custos e maior efetividade em ambas as comparações, com economias projetadas para os três primeiros anos de -R$ 3.874,00 e -R$ 3.996,00, respectivamente. O BIM estimou uma economia cumulativa de R$ 417.958,00 com o reembolso da saxagliptina em três anos a partir da perspectiva de uma operadora de plano de saúde com 1 milhão de vidas cobertas. CONCLUSÃO: Da perspectiva da fonte pagadora privada, a projeção é de que o acréscimo de saxagliptina à MF poupe custos quando comparado ao acréscimo de rosiglitazona ou pioglitazona em pacientes com DMT2 que não atingiram a meta de hemoglobina glicada (HbA1c com metformina em monoterapia. O BIM, para a inclusão de saxagliptina nas listas de reembolso das operadoras de planos de saúde, indicou uma economia significativa para o horizonte de 3 anos.OBJECTIVES: To compare costs and clinical benefits of three additional therapies to metformin (MF for patients with diabetes mellitus type 2 (DM2. METHODS: A discrete event simulation model was built to estimate the cost-utility ratio (cost per quality-adjusted life years [QALY] of saxagliptine as an

  1. Yoga Practice for the Management of Type II Diabetes Mellitus in Adults: A systematic Review

    Directory of Open Access Journals (Sweden)

    Badr Aljasir

    2010-01-01

    Full Text Available The effect of practicing yoga for the management of type II Diabetes was assessed in this systematic review through searching related electronic databases and the grey literature to the end of May 2007 using Ovid. All randomized controlled clinical trials (RCTs comparing yoga practice with other type of intervention or with regular practice or both, were included regardless of language or type of publication. Each study was assessed for quality by two independent reviewers. Mean difference was used for summarizing the effect of each study outcomes with 95% confidence intervals. Pooling of the studies did not take place due to the wide clinical variation between the studies. Publication bias was assessed by statistical methods. Five trials with 363 participants met the inclusion criteria with medium to high risk of bias and different intervention characteristics. The studies’ results show improvement in outcomes among patients with diabetes type II. These improvements were mainly among short term or immediate diabetes outcomes and not all were statistically significant. The results were inconclusive and not significant for the long-term outcomes. No adverse effects were reported in any of the included studies. Short-term benefits for patients with diabetes may be achieved from practicing yoga. Further research is needed in this area. Factors like quality of the trials and other methodological issues should be improved by large randomized control trials with allocation concealment to assess the effectiveness of yoga on diabetes type II. A definitive recommendation for physicians to encourage their patients to practice yoga cannot be reached at present.

  2. Reprodutibilidade da medida ambulatorial da pressão arterial em pacientes hipertensos com diabete melito tipo 2 Reproducibility of ambulatory blood pressure monitoring in hypertensive patients with type 2 diabetes mellitus

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    João Soares Felício

    2007-02-01

    Full Text Available OBJETIVO: Avaliar a reprodutibilidade e o efeito placebo sobre a monitorização ambulatorial da pressão arterial (MAPA (SpaceLabs-90207. MÉTODOS: Mensurou-se a PA no consultório e por meio de duas MAPA, realizadas em um intervalo de 1 a 10 meses (média de 4,9 meses, de 26 pacientes com diabetes tipo 2 e hipertensão. Onze pacientes (G1 realizaram as duas MAPA sem medicação anti-hipertensiva por 15 dias, enquanto o G2 (N = 15 fez a segunda MAPA em uso de placebo pelo mesmo período. RESULTADOS: Ao avaliarmos os coeficientes de variação (CV da PA sistólica na vigília (PASV, PA diastólica na vigília (PADV, PA sistólica nas 24h (PAS24h e PA diastólica nas 24h (PAD24h, encontramos valores de 4,6%, 3,9%, 5,0% e 4,0% no G1 e 4,3%, 5,1%, 3,7% e 5,1% no G2, respectivamente. Quanto ao CV da PA sistólica e diastólica durante o sono (PASS e PADS, encontramos 7,7% e 8,2% para G1, e 5,6% e 6,3% para G2, respectivamente. O CV da freqüência cardíaca na vigília e durante o sono foram: G1 = 5,9% e 9,0%, G2 = 6,9% e 5,8%, respectivamente. Analisando o total dos pacientes, todas as variáveis mostraram fortes correlações entre a primeira e a segunda MAPA (PASV, r=0,76; POBJECTIVE: To evaluate the reproducibility of ambulatory blood pressure monitoring (ABPM (SpaceLabs-90207 and placebo effect on ABPM. METHODS: Blood pressure was measured in the office and over two ABPM periods with an interval from one to ten months (mean 4.9 months, in 26 patients with type 2 diabetes mellitus and hypertension. Eleven patients (G1 had two ABPMs without taking antihypertensive drugs for 15 days, whereas G2 (N=15 had the second ABPM after administration of a placebo for 15 days. RESULTS: In the evaluation of the coefficient of variation (CV of diurnal (awake systolic BP (DSBP, of diurnal (awake diastolic BP (DDBP, of 24-hour systolic BP (24hSBP and of 24-hour diastolic BP (24hDBP, the values found were 4.6%, 3.9%, 5.0%, 4.0% for G1 and 4.3%, 5.1%, 3.7%, 5

  3. Studies of variability in the PTEN gene among Danish caucasian patients with Type II diabetes mellitus

    DEFF Research Database (Denmark)

    Hansen, L; Jensen, J N; Ekstrøm, C T

    2001-01-01

    Phosphatase and tensin homologue deleted from chromosome ten (PTEN) has recently been characterized as a novel member in the expanding network of proteins regulating the intracellular effects of insulin. By dephosphorylation of phosphatidyl-inositol-(3, 4, 5)-trisphosphate (PIP3) the PTEN protein...... regulates the insulin-dependent phosphoinositide 3-kinase (PI3K) signalling cassette and accordingly might function as a regulator of insulin sensitivity in skeletal muscle and adipose tissue. In this study we tested PTEN as a candidate gene for insulin resistance and late-onset Type II (non...

  4. Cuidados de Enfermería en la Diabetes Mellitus Lada

    OpenAIRE

    Gutiérrez Velicia, Soraya

    2015-01-01

    La Diabetes Mellitus es una enfermedad crónica producida por una alteración del metabolismo de la glucosa que se caracteriza por la presencia de concentraciones elevadas de glucosa en sangre, lo que se conoce como hiperglucemia. Es el trastorno endocrino crónico más prevalente. Se conocen diferentes formas de Diabetes Mellitus según su etiología: Diabetes Mellitus tipo 1, Diabetes Mellitus tipo 2, Diabetes Mellitus gestacional y otros tipos de Diabetes Mellitus como son la t...

  5. Pupil cycle time and contrast sensitivity in type II diabetes mellitus patients: A pilot study

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    Hoyoung Lee

    2011-01-01

    Full Text Available Context: Pupil cycle time (PCT has been widely used for examination of ocular diabetic autonomic neuropathy (DAN. Aims: The primary aim of this study was to evaluate the difference of contrast sensitivity according to PCT results, and the secondary aim was to determine the factors associated with PCT difference for type II diabetes patients. Settings and Design: A clinical pilot study that included a total of 60 eyes of 60 type II diabetes patients. Materials and Methods: We divided all patients into three groups according to PCT results. Group A and Group C were composed of patients who had upper one third PCT and lower one third PCT, respectively. We analyzed difference of age, diabetes duration, hypertension duration, mean best corrected visual acuity (BCVA, mean spherical equivalent (SE, HbA1C, glomerular filtration rate (GFR, stage of diabetic retinopathy, and Cardiac Autonomic Function Score (CAFS. Contrast sensitivity and decrease of visual acuity by glare were also estimated and analyzed for 28 eyes of 28 non-proliferative diabetic retinopathy (NPDR patients. Group [NPDR] A and Group [NPDR] C were defined as those who had lower one third PCT and upper one third PCT, respectively. Statistical Analysis: Statistical analysis was done using SPSS 17.0 software. Results and Conclusions: Each group contained 20 eyes. Significant differences between Group A and Group C were observed in duration of diabetes and CAFS (P ≤ 0.001 and P < 0.001, respectively. Contrast sensitivity in Group [NPDR] A was significantly more than in Group [NPDR] C at all cpds (all P ≤ 0.001. We found that PCT can influence contrast sensitivity or glare in diabetes patients and also confirmed a significant correlation of PCT with CAFS and duration of diabetes.

  6. Intracellular insulin processing is altered in monocytes from patients with type II diabetes mellitus

    International Nuclear Information System (INIS)

    Trischitta, V.; Benzi, L.; Brunetti, A.; Cecchetti, P.; Marchetti, P.; Vigneri, R.; Navalesi, R.

    1987-01-01

    We studied total cell-associated A14-[ 125 I]insulin radioactivity (including surface-bound and internalized radioactivity), insulin internalization, and its intracellular degradation at 37 C in monocytes from nonobese type II untreated diabetic patients (n = 9) and normal subjects (n = 7). Total cell-associated radioactivity was decreased in diabetic patients [2.65 +/- 1.21% (+/- SD) vs. 4.47 +/- 1.04% of total radioactivity. Insulin internalization was also reduced in diabetic patients (34.0 +/- 6.8% vs. 59.0 +/- 11.3% of cell-associated radioactivity. Using high performance liquid chromatography six intracellular forms of radioactivity derived from A14-[ 125 I] insulin were identified; 10-20% of intracellular radioactivity had approximately 300,000 mol wt and was identified as radioactivity bound to the insulin receptor, and the remaining intracellular radioactivity included intact A14-[ 125 I]insulin, [ 125 I]iodide, or [ 125 I]tyrosine, and three intermediate compounds. A progressive reduction of intact insulin and a corresponding increase in iodine were found when the incubation time was prolonged. Intracellular insulin degradation was reduced in monocytes from diabetic patients; intracellular intact insulin was 65.6 +/- 18.1% vs. 37.4 +/- 18.0% of intracellular radioactivity after 2 min and 23.6 +/- 22.3% vs. 3.9 +/- 2.3% after 60 min in diabetic patients vs. normal subjects, respectively. In conclusion, 1) human monocytes internalize and degrade insulin in the intracellular compartment in a stepwise time-dependent manner; and 2) in monocytes from type II diabetic patients total cell-associated radioactivity, insulin internalization, and insulin degradation are significantly reduced. These defects may be related to the cellular insulin resistance present in these patients

  7. Spinal muscular atrophy type II (intermediary and III (Kugelberg-Welander: evolution of 50 patients with physiotherapy and hydrotherapy in a swimming pool Atrofia muscular espinhal tipo II (intermediária e III (Kugelberg-Welander: evolução de 50 pacientes com fisioterapia e hidroterapia em piscina

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    Márcia C. B. Cunha

    1996-09-01

    Full Text Available We added hydrotherapy to 50 patients with spinal muscular atrophy (SMA who were being treated with individual conventional physiotherapy. Hydrotherapy was performed at an approximate temperature of 30 degrees Celsius, twice a week, for thirty minutes in children and for forty-five minutes in adults during a 2-year period. The outcome derived from this combined modality of treatment was rated according to physiotherapeutic evaluations, the MMT (Manual Muscular Test, and the Barthel Ladder. Patients were reevaluated at 2-month intervals. After two years of ongoing treatment, we were able to observe that the deformities in hip, knee and foot were progressive in all SMA Type II patients, and in some Type III. Muscle strength stabilized in most SMA Type III patients, and improved in some. MMT was not done in SMA Type II. In all patients we were able to detect an improvement in the Barthel Ladder scale. This study suggests that a measurable improvement in the quality of daily living may be obtained in patients with SMA Types II and III subjected to conventional physiotherapy when associated with hydrotherapy.A hidroterapia foi realizada em SO pacientes com atrofia muscular espinhal, os quais foram também tratados com fisioterapia individual convencional. O tratamento hidroterápico foi realizado em piscina aquecida numa temperatura de aproximadamente 30° Celsius, duas vezes por semana, durante 30 minutos em crianças e 45 minutos em adultos num período de dois anos. Os benefícios deste tipo de tratamento foram avaliados de acordo com a evolução clínica, o MMT(Teste de Força Muscular e a Escala de Barthel. Os pacientes foram reavaliados a cada dois meses. Após dois anos de tratamento nós observamos que as deformidades nos quadris, joelhos e pés foram progressivas em todos os pacientes do Tipo II e em alguns do Tipo III. Houve estabilização da força muscular na maioria dos pacientes com SMA Tipo III, e melhora da força em alguns; nos

  8. Frecuencia y características clínicas de la nefropatìa incipiente en personas con diabetes mellitus tipo 2 de diagnóstico reciente Frequency and clinical characteristics of incipient neuropathy in persons recently diagnosed with diabetes mellitus type 2

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    Manuel E. Licea Puig

    2003-04-01

    Full Text Available El objetivo de este trabajo fue determinar la frecuencia y las características clínicas de la nefropatía diabética incipiente (NDI en personas con diabetes mellitus tipo 2 (DM2 de diagnóstico reciente, negativos en relación con los anticuerpos antislotes pancreáticos (ICA y la antidescarboxilasa del ácido glutámico (AGAD. Se estudiaron 183 personas con DM2 (ICA y AGAD negativos, atendidas en el Centro de Atención al Diabético, con la evaluación de las siguientes variables: edad, sexo, hábito de fumar, índice de masa corporal (IMC, edad al debut, tipo de tratamiento de la DM, presencia de retinopatía diabética (RD y la presión arterial, así como la glucemia en ayunas y posprandial. Se determinó ICA, AGAD, hemoglobina glucosilada (HbA1, glucemia en ayuna y postprandial 2 horas después del desayuno y del almuerzo, así como excreción urinaria de albúmina (EUA en orina de 24 horas. No se incluyó a pacientes con ND diabética clínica (EUA ³ 300 mg/L, con nefropatía no diabética, ni con otras causas o condiciones de aumento de EUA. Los sujetos se dividieron en 2 grupos: normoalbuminúricos (EUA £ 20 mg/L N = 163, y microalbuminúricos (NDI incipiente EUA > 20 a The objective of this paper was to determine the frequency and clinical characteristics of incipient diabetic nephropathy(IDN in persons with type 2 diabetes mellitus of recent diagnosis negatives for pancreatic islet cell antibodies (ICA and glutamic acid decarboxylase antibodies(AGAD. One-hundred and three persons with DM2 (negative ICA and AGAD, seen at the Diabetic Care Center, were studied and evaluated according to the following variables: age, sex, smoking, body mass index (BMI; age of onset of diabetes, type of DM treatment, presence of diabetic retinopathy (DR and blood pressure as well as glucemia at fasting and postprandial. The study determined ICA, AGAD, glycosylated hemoglobin(HbA1, glucemia at fasting and postprandial two hours after breakfast and

  9. Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers reduced dementia risk in patients with diabetes mellitus and hypertension.

    Science.gov (United States)

    Kuan, Yi-Chun; Huang, Kuang-Wei; Yen, Der-Jen; Hu, Chaur-Jong; Lin, Cheng-Li; Kao, Chia-Hung

    2016-10-01

    The effects of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) on dementia risk in patients with type 2 diabetes mellitus (DM) and hypertension remain unknown. We investigated the effects of ACEIs and ARBs on dementia risk in patients with type 2 DM and hypertension. We conducted a cohort study by using the Taiwan National Health Insurance Research Database. We included 2377 patients receiving ACEIs and 1780 patients receiving ARBs in the ACEI and ARB cohorts, respectively. We included a comparable number of patients not receiving ACEIs and ARBs as controls in the non-ACEI and non-ARB cohorts through propensity score matching. The effect of ACEIs and ARBs on dementia risk was estimated through multivariate Cox proportional hazard regression after adjustment for several confounding factors. During the 12-year follow-up period, compared with the non-ACEI cohort, all-cause dementia risk decreased by 26% in the ACEI cohort [hazard ratio (HR)=0.74, 95% confidence interval (CI)=0.56-0.96]. The all-cause dementia risk was nearly 40% lower in the ARB cohort than in the non-ARB cohort (HR=0.60, 95% CI=0.37-0.97). These drugs prevented the occurrence of vascular dementia (VD), however, this effect was nonsignificant for Alzheimer's dementia (AD). Treatment duration- and dosage-related protection effects on dementia occurrence were observed. ACEIs and ARBs may effectively prevent all-cause dementia, particularly VD, in patients with type 2 DM and hypertension. Moreover, compared with ACEIs, ARBs appear to be more advantageous in dementia prevention. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  10. Relação entre o perfil antropométrico e bioquímico em crianças e adolescentes com diabetes melito tipo 1 Relación entre perfiles antropométrico y bioquímico en niños y adolescentes con diabetes mellitus tipo 1 Relationship between anthropometric and biochemical profiles in children and adolescents with type 1 diabetes

    Directory of Open Access Journals (Sweden)

    Sheylle Almeida S. Teles

    2012-01-01

    Full Text Available OBJETIVO: Avaliar a relação entre o perfil antropométrico e bioquímico de crianças e adolescentes com diabetes melito tipo 1 (DM1. MÉTODOS: Estudo transversal com 11 crianças e 43 adolescentes com DM1. Coletaram-se dados socioeconômicos e demográficos (idade, sexo, escolaridade, renda, clínicos (insulinoterapia, antropométricos (peso, estatura, dobras cutâneas, circunferência da cintura - CC e bioquímicos (hemoglobina glicada - HbA, glicemias casual - GLC, pós-prandial - GLPP, e perfil lipídico. Foram utilizados o teste t de Student (pOBJETIVO: Evaluar la relación entre perfil antropométrico y bioquímico de niños y adolescentes con diabetes mellitus tipo 1 (DM1. MÉTODOS: Estudio transversal con 11 niños y 43 adolescentes con DM1. Se recogieron datos socioeconómicos y demográficos (edad, sexo, escolaridad, ingresos, clínicos (insulinoterapia, antropométricos (peso, estatura, pliegues cutáneos, circunferencia de la cintura-CC y bioquímicos (hemoglobina glicada - HbA, glucemias casual - GLC, postprandial - GLPP y perfil lipídico. Se utilizaron la prueba t de Student y la correlación de Pearson (pOBJECTIVE: To evaluate the relationship between anthropometric and biochemical variables in children and adolescents with type 1 diabetes mellitus (DM1. METHODS: This was a cross-sectional study of 11 children and 43 adolescents with DM1. The following data were collected: socioeconomic and demographic (age, sex, education, income, clinical (insulin therapy, anthropometric (weight, height, skinfolds, waist circumference - WC and biochemical variables (glycated hemoglobin - HbA, casual blood glucose - CBG, post-prandial blood glucose - PPBG, and lipid profile. Statistical analysis included Student's t test (p<0.05 and Pearson's correlation (p<0.05. RESULTS: The average income per capita was 0.58±0.39 times the monthly minimum wage and 72.2% of the sample were on insulin therapy consisting of three doses per day. Most

  11. The Impact of Patient Education on Anthropometric, Lipidemic, and Glycemic Parameters Among Patients With Poorly Controlled Type II Diabetes Mellitus: A 3-Month Prospective Single-Center Turkish Study.

    Science.gov (United States)

    Cander, Soner; Gul, Ozen Oz; Gul, Cuma B; Keles, Saadet B; Yavas, Sibel; Ersoy, Canan

    2014-12-01

    This study evaluated the impact of patient education on adherence to a diabetes care plan (e.g., anthropometric, lipidemic, and glycemic parameters) among adults with type II diabetes mellitus without adequate glycemic control. A total of 61 ambulatory adults with type II diabetes mellitus (mean age: 53.6 ± 8.2 years, 70.5% female) were evaluated for anthropometrics, duration of diabetes mellitus, type of anti-diabetic treatment, blood biochemistry, and glycemic parameters in this 3-month prospective observational single-center study. During the course of the study, participants demonstrated a significant decrease in body weight and fat percentage and HbA1c (p diabetes mellitus who received education on adherence to routine self-monitoring of blood glucose, standard diabetic diet, and an exercise program delivered by certified diabetes educators had better glycemic control and significant decrease in body weight and fat percentage over a 3-month monitoring period. Copyright 2014, SLACK Incorporated.

  12. Codificación geométrica y análisis de conglomerados para evaluar el control metabólico de pacientes con diabetes mellitus tipo 2 Geometric coding and cluster analysis to assess metabolic control of patients with type 2 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Ramón Alberto Rascón-Pacheco

    2010-04-01

    Full Text Available OBJETIVO: Determinar la frecuencia de las combinaciones de los parámetros de control metabólico por arriba de lo normal, usando la codificación geométrica y el análisis jerárquico de conglomerados, en pacientes con diabetes mellitus tipo 2 (DM2. MÉTODOS: Se desarrolló en México un estudio transversal descriptivo para evaluar a un grupo de 1 051 pacientes con DM2, cuyos criterios de inclusión eran tener uno o más de los siguientes valores: glucosa en ayunas > 130 mg/dL, colesterol total > 240 mg/dL, triglicéridos totales > 200 mg/dL, índice de masa corporal > 27 kg/m², y presión arterial sistólica mayor de 130 mmHg o presión arterial diastólica mayor de 85 mmHg. Por medio de codificaciones geométricas se obtuvieron las frecuencias de todas las combinaciones. Para definir similitudes entre las combinaciones se utilizó el método de análisis de conglomerados. RESULTADOS: Utilizando el instrumento propuesto, se observó que la combinación en pares con mayor número de sujetos estuvo representada por hiperglucemia-hipertrigliceridemia (7,3% e hiperglucemia-hipercolesterolemia (3,6%. Las policombinaciones de mayor frecuencia fueron hiperglucemia-hipercolesterolemia-hipertrigliceridemia (13,2% e hiperglucemia- hipertrigliceridemia-hipercolesterolemia-hipertensión (10,5%. CONCLUSIONES: La codificación geométrica y el análisis por conglomerados podrían llegar a ser un instrumento idóneo para evaluar el control metabólico de los pacientes con DM2, así como para identificar parámetros que contribuyan a mejorar su monitoreo y su tratamiento.OBJECTIVE: Determine the frequency of combinations of higher-than-normal metabolic control parameters, using geometric coding and hierarchical cluster analysis, in patients with type 2 diabetes (DM2 METHODOLOGY: A descriptive cross-sectional study was conducted in Mexico to assess a group of 1 051 patients with DM2. The inclusion criteria were to have one or more of the following values

  13. Auto-aplicação de insulina em crianças portadoras de diabetes mellitus tipo 1 Auto-aplicación de insulina en niños diabéticos tipo 1 Self-administration of insulin by diabetic type 1 children

    Directory of Open Access Journals (Sweden)

    Cristina Dall'Antonia

    2000-07-01

    Full Text Available Estudo de natureza descritiva que tem por objetivos caracterizar a criança diabética tipo 1, segundo as variáveis sócio-demográficas e identificar as dificuldades relacionadas a auto-aplicação de insulina e controle domiciliar. Foram entrevistadas 34 crianças diabéticas tipo 1, em um hospital de grande porte. Os resultados obtidos apontam que as crianças são brancas (82,4%, feminina (61,8%, idade entre nove e onze anos (54,1% católicas (67,7%, são portadoras da doença há três anos (64,3%. Aprenderam a administrar a insulina com as mães (35,3%, realizam rodízio para auto-aplicação (32,3%. As dificuldades para realizar o controle domiciliar estão relacionadas aos recursos disponíveis e a falta de informação. Os resultados indicam a necessidade de um trabalho planejado e integrado da equipe multiprofissional a criança que atenda a cada aspecto abordado, observando a sua independência para o êxito do cuidado à criança diabética tipo 1.Estudio de naturaleza descriptiva que tiene por objetivos caracterizar el niño diabético tipo 1, de acuerdo con las variables demográficas e identificar las dificultades relacionadas a la auto-aplicación de insulina y su control domiciliario. Fueron entrevistados 34 niños diabéticos tipo 1, en un hospital de gran porte. Los resultados obtenidos muestran que son niños blancos (82,4%, mujeres (61,8%, edad entre nueve Y once años (54,1%, católicos (67,7%, son portadores de la enfermedad por tres años (64,3%. Aprendieron a administrarse la insulina con las madres (35,3%, realizan rotación para auto-aplicación (32,3%. Las dificultades para realizar el control domiciliario están relacionadas con los recursos disponibles y con la falta de información. Los resultados indican la necesidad de un trabajo planeado e integrado por el equipo multiprofesional que atienda cada aspecto abordado, observando su independencia para el éxito del cuidado al niño diabético tipo 1.The present

  14. A mixed-methods needs assessment of adult diabetes mellitus (type II) and hypertension care in Toledo, Belize.

    Science.gov (United States)

    Dekker, Annette M; Amick, Ashley E; Scholcoff, Cecilia; Doobay-Persaud, Ashti

    2017-02-28

    Non-communicable diseases, including diabetes mellitus and hypertension, continue to disproportionately burden low- and middle-income countries. However, little research has been done to establish current practices and management of chronic disease in these settings. The objective of this study was to examine current clinical management and identify potential gaps in care of patients with diabetes mellitus and hypertension in the district of Toledo, Belize. The study used a mixed methodology to assess current practices and identify gaps in diabetes mellitus and hypertension care. One hundred and twenty charts of the general clinic population were reviewed to establish disease epidemiology. One hundred and seventy-eight diabetic and hypertensive charts were reviewed to assess current practices. Twenty providers completed questionnaires regarding diabetes mellitus and hypertension management. Twenty-five individuals with diabetes mellitus and/or hypertension answered a questionnaire and in-depth interview. The prevalence of diabetes mellitus and hypertension was 12%. Approximately 51% (n = 43) of patients with hypertension were at blood pressure goal and 26% (n = 21) diabetic patients were at glycemic goal based on current guidelines. Of the patients with uncontrolled diabetes, 49% (n = 29) were on two oral agents and only 10% (n = 6) were on insulin. Providers stated that barriers to appropriate management include concerns prescribing insulin and patient health literacy. Patients demonstrated a general understanding of the concept of chronic illness, however lacked specific knowledge regarding disease processes and self-management strategies. This study provides an initial overview of diabetes mellitus and hypertension management in a diverse patient population in rural Belize. Results indicate areas for future investigation and possible intervention, including barriers to insulin use and opportunities for lifestyle-specific disease education for

  15. Seropositividad al virus linfotrópico de células T humanas tipos I y II en donantes del Banco Municipal de Sangre de Caracas y factores de riesgo asociados

    Directory of Open Access Journals (Sweden)

    Graciela León

    2003-03-01

    Full Text Available OBJETIVOS: Conocer la proporción de sangre descartada por seropositividad al virus linfotrópico de células T humanas (HTLV tipos I y II, la prevalencia de dicha infección y los probables factores de riesgo en donantes del Banco Municipal de Sangre de Caracas (BMSC. MÉTODOS: Se evaluaron serológicamente mediante ensayos de inmunoadsorción enzimática (ELISA 23 413 donantes atendidos entre julio del año 2000 y abril de 2001 en el BMSC. Las muestras repetidamente reactivas (RR se estudiaron por inmunoblot de Western (WB, como prueba suplementaria. Los donantes positivos o indeterminados por WB fueron citados a la consejería para realizar la confirmación mediante la amplificación de ácidos nucleicos por reacción en cadena de la polimerasa (PCR, recoger datos sobre sus antecedentes de riesgo y asesorarlos acerca de su estado. RESULTADOS. El 0,2% de las donaciones resultaron RR; de ellas 52,1% resultaron positivas en el WB (23 a HTLV I y 2 a HTLV II; 4,1% indeterminadas por WB; 29,2% negativas; y el 14,6% no pudo ser evaluado. Asistieron a la consejería 16 donantes (14 WB positivos a HTLV I, 1 a HTLV II y 1 indeterminado. Todos resultaron positivos en la RCP. No se encontraron diferencias significativas con el grupo control en cuanto a edad, sexo, tipo de donación, número de donaciones previas, antecedentes de transfusiones y comportamiento sexual. Se observaron diferencias significativas según los antecedentes de consumo de drogas no intravenosas (P < 0,05, y altamente significativas (P < 0,001 según los antecedentes de lactancia materna larga. Las madres estudiadas de seis de los donantes positivos que manifestaron haber tenido una larga lactancia materna resultaron positivas, al igual que el hijo mayor de la única pareja positiva de las 13 evaluadas. CONCLUSIONES. Se descartó el 0,2% de la sangre por resultar positiva al HTLV I/II. La prevalencia entre los donantes fue de 0,11%. En el 37,5% de los casos se pudo determinar la

  16. Seropositividad al virus linfotrópico de células T humanas tipos I y II en donantes del Banco Municipal de Sangre de Caracas y factores de riesgo asociados

    Directory of Open Access Journals (Sweden)

    León Graciela

    2003-01-01

    Full Text Available OBJETIVOS: Conocer la proporción de sangre descartada por seropositividad al virus linfotrópico de células T humanas (HTLV tipos I y II, la prevalencia de dicha infección y los probables factores de riesgo en donantes del Banco Municipal de Sangre de Caracas (BMSC. MÉTODOS: Se evaluaron serológicamente mediante ensayos de inmunoadsorción enzimática (ELISA 23 413 donantes atendidos entre julio del año 2000 y abril de 2001 en el BMSC. Las muestras repetidamente reactivas (RR se estudiaron por inmunoblot de Western (WB, como prueba suplementaria. Los donantes positivos o indeterminados por WB fueron citados a la consejería para realizar la confirmación mediante la amplificación de ácidos nucleicos por reacción en cadena de la polimerasa (PCR, recoger datos sobre sus antecedentes de riesgo y asesorarlos acerca de su estado. RESULTADOS. El 0,2% de las donaciones resultaron RR; de ellas 52,1% resultaron positivas en el WB (23 a HTLV I y 2 a HTLV II; 4,1% indeterminadas por WB; 29,2% negativas; y el 14,6% no pudo ser evaluado. Asistieron a la consejería 16 donantes (14 WB positivos a HTLV I, 1 a HTLV II y 1 indeterminado. Todos resultaron positivos en la RCP. No se encontraron diferencias significativas con el grupo control en cuanto a edad, sexo, tipo de donación, número de donaciones previas, antecedentes de transfusiones y comportamiento sexual. Se observaron diferencias significativas según los antecedentes de consumo de drogas no intravenosas (P < 0,05, y altamente significativas (P < 0,001 según los antecedentes de lactancia materna larga. Las madres estudiadas de seis de los donantes positivos que manifestaron haber tenido una larga lactancia materna resultaron positivas, al igual que el hijo mayor de la única pareja positiva de las 13 evaluadas. CONCLUSIONES. Se descartó el 0,2% de la sangre por resultar positiva al HTLV I/II. La prevalencia entre los donantes fue de 0,11%. En el 37,5% de los casos se pudo determinar la

  17. Síndrome de Usher de tipo II: caracterización oftalmológica, auditiva y genética de una familia consanguínea

    OpenAIRE

    Freyre Luque, Rásife; García Espinosa, Sarah María; García Mayet, Idalmis; Santisteban Aguilera, Francisca; Dager Salomón, Melek

    2011-01-01

    Se caracterizó a una familia consanguínea de 25 miembros, 3 de los cuales padecían el síndrome de Usher de tipo II, a través del estudio auditivo, oftalmológico y genético en el Centro de Retinosis Pigmentaria de Santiago de Cuba. Los pacientes (2 varones y 1 fémina) tenían en común: aparición de la enfermedad en la etapa juvenil, mala visión nocturna, campos visuales reducidos, hipoacusia neurosensorial y resultados normales en las pruebas vestibulares; asimismo, en genética molecular, la el...

  18. Diabetes mellitus tipo 1 na ausência de neuropatia autonômica não altera a taxa de sudorese no exercício Type 1 diabetes mellitus in the lack of autonomic neuropathy does not alter the sudoresis rate in exercise

    Directory of Open Access Journals (Sweden)

    Cristiane Martins Rocha

    2009-02-01

    Full Text Available A sudorese é o principal mecanismo autonômico termorregulatório na espécie humana. A taxa de sudorese (TS durante o exercício pode ser influenciada por diversos fatores, entre eles doenças, como o diabetes mellitus tipo 1, cujos pacientes são vítimas potenciais de distúrbios termorregulatórios. Os exercícios regulares são recomendados para diabéticos e, inclusive, alguns deles tornam-se atletas. No entanto, ainda não foi medida a TS de diabéticos durante exercício progressivo até a exaustão (GXT e comparada com a de indivíduos sadios com características antropométricas semelhantes. O presente estudo comparou a TS de sete voluntários diabéticos (DM e sete controles (GC, semelhantes quanto à idade, gênero, composição corporal e capacidade aeróbica. Antes e após o GXT, foram medidos a gravidade específica da urina (GEU, o peso e a glicemia capilar. A TS global foi calculada dividindo-se a variação do peso pelo tempo de coleta e área de superfície corporal. A TS local do antebraço foi calculada utilizando-se a variação do peso de um filtro absorvente corrigido pela sua área e tempo de coleta. As TS locais do antebraço e da perna foram induzidas por iontoforese com pilocarpina (0,5% no grupo DM. A freqüência cardíaca (FC foi registrada antes, durante e após GXT. A temperatura média da pele (TMP e as condições térmicas ambientais foram medidas durante o experimento. A glicemia capilar foi maior no DM, como o esperado. As TS global e local foram semelhantes entre os grupos, enquanto que a FC no repouso e a TMP no repouso e no exercício foram maiores no DM. Não houve diferença entre as TS do antebraço e da perna no DM com a pilocarpina. Concluiu-se que a resposta sudorípara foi semelhante entre diabéticos jovens e grupo controle durante exercício progressivo em ambiente temperado.Sudoresis is the main autonomic human thermoregulatory mechanism. It can be influenced by several factors, including

  19. Adaptación y validación del instrumento de calidad de vida Diabetes 39 en pacientes mexicanos con diabetes mellitus tipo 2 Adaptation and validation of quality of life instrument Diabetes 39 for Mexican patients with type 2 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Juan Manuel López-Carmona

    2006-06-01

    Full Text Available OBJETIVO: Adaptar y validar la versión al español del cuestionario Diabetes 39, que mide calidad de vida, en pacientes mexicanos con diabetes mellitus tipo 2 (DM-2 MATERIAL Y MÉTODOS: Encuesta transversal realizada en una unidad de medicina familiar. Un panel de investigadores adaptó el instrumento, que se aplicó en dos ocasiones, por autoadministración, a una muestra de 260 pacientes con DM-2. Se midieron la hemoglobina glucosilada (HbA1C, colesterol total, triglicéridos, tensión arterial, índice de masa corporal e índice cintura/cadera. Se obtuvieron datos sobre edad, sexo, tiempo de evolución, complicaciones diabéticas y comorbilidad RESULTADOS: Completaron el estudio 249 sujetos de los cuales 62.7% fueron mujeres. El alfa de Cronbach fue >0.80 para los dominios. La consistencia test-retest para la calificación total tuvo una r= 0.82, p= 0.01. La mediana de la puntuación total fue de 29 puntos (escala de 0 a 100 y se tomó como punto de corte para definir mejor (29 calidad de vida. En el análisis bivariado, una peor calidad de vida se asoció con complicaciones tardías de la diabetes >1 (RM= 1.73; IC95% 1.05-3.06; colesterol total >240 mg/dL (RM= 4.43; IC95% 1.23-16.26; comorbilidad >2 enfermedades (RM= 2.36; IC95% 1.31-4.28; evolución mayor a 10 años (RM= 2.19; IC95% 1.27-3.78 y HbA1C >8% (RM= 1.81; IC95% 1.09-2.99. Las tres últimas fueron predictoras de peor calidad de vida en la regresión logística (pOBJECTIVE:To adapt and validate the Spanish language version of the Diabetes 39 instrument, which measures quality of life, for Mexican patients with type 2 diabetes mellitus (DM-2 MATERIALS AND METHODS: The Spanish language version of the instrument was adapted to make it more comprehensible to Mexican patients. In a cross-sectional survey, the instrument was administered on two different days to 260 patients with type DM-2. Glycated hemoglobin (HbA1C, total cholesterol, triglycerides, blood pressure, body mass index and

  20. Genetic linkage analysis of type 1 diabetes mellitus to markers on chromosomes 2 and 11 in families from Antioquia, Colombia Análisis de ligamiento genético de la diabetes mellitus tipo 1, a marcadores de los cromosomas 2 y 11 en familias antioqueñas

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    Gabriel Bedoya Berrío

    2004-02-01

    in DM1 the maximum odds ratio (Lod score or Z maximum was 3.57 without recombination (=0=0, above 3, the accepted value for determining linkage; when the three families were taken together, a maximum Z of 5.76 was obtained. With the linkage analysis for chromosome 11, it was found that only in family 10 there was a positive Z value, 1.18 to marker D11S925 with =0=0, above the simulation value for this family (0.75; as regards chromosome 2, positive Z values were obtained to marker D2S319 in DM1 and family 10: 2.08 and 0.88, respectively, with =0=0. When the three families were taken as a whole and Z values were calculated for markers D11S925 and D2S319, a value of 2.5 was obtained, with =0=0, which confirms that in the analysed families 2 loci are involved, located in the regions of chromosomes 11 and 2 signaled by such markers. If it is taken into account that the D1S925 marker is located in the region 11q23-3, and the D2S319 marker, in the region 2qter, it may be said that in this work two new loci of susceptibility to DM1 have been identified in three families from Antioquia, Colombia, since these regions do not agree with those so far reported; besides, since results were negative in linkage analysis to IDDM1(data not shown, the studied cases of DM1 could be classified as DM1B. La Diabetes Mellitus (DM comprende un grupo heterogéneo de desordenes hiperglucémicos clasificados en subgrupos de acuerdo a su fisiopatología y etiología, entre los cuales se destacan la Diabetes Mellitas tipo1 (DM1 y la diabetes mellitus tipo 2 (DM2. La DM1 es de aparición temprana y una absoluta escasez de insulina hace que los pacientes sean insulino dependientes desde el inicio de los síntomas y la (DM2, de inicio en la edad adulta y no todos los pacientes que la sufren son insulino dependientes. La DM1 se clasifica como DM1A si es el efecto de una respuesta autoinmune por parte de las células ? del páncreas y DM1B si la causa es desconocida (idiopática. Los estudios sobre

  1. As implicações da classe II de angle e da desproporção esquelética tipo classe II no aspecto miofuncional The implications of class II angle and class II type skeletal disproportion on the myofunctional aspect

    Directory of Open Access Journals (Sweden)

    Carolina Lisbôa Mezzomo

    2011-08-01

    Full Text Available TEMA: esse trabalho foi baseado na temática de que existe uma associação entre as más oclusões devido a alterações do crescimento craniofacial, e, por conseguinte, a existência de alterações miofuncionais. OBJETIVOS: estudar a associação entre as más oclusões tipo classe II desencadeadas por alterações do crescimento craniofacial e as disfunções do sistema estomatognático (alterações miofuncionais: fala, mastigação, deglutição e fonação. CONCLUSÃO: pode-se concluir que alterações estruturais da face podem ter influência na funcionalidade das mesmas, portanto, enfatiza-se a importância do trabalho multidisciplinar entre os profissionais envolvidos em cada uma dessas aéreas para que o prognóstico desses casos seja pertinente de relevantes melhoras.BACKGROUND: this work has been based on the theme that there is an association between malocclusion due to change in craniofacial growth, and therefore, the existence of malfunctioning abnormalities. PURPOSE: to study the strong association among the malocclusion class II triggered by changes in craniofacial growth and dysfunctions of the stomatognathic system (myofunctional disorders - speech, chewing, swallowing and phonation. CONCLUSION: it may be concluded that structural changes of the face may affect its, and therefore, the importance of multidisciplinary work among professionals involved in each of those areas, is emphasized, so that the prognosis of these cases may have relevant and important improvements.

  2. Programa de ejercicios físicos y educación diabetológica para diabéticos tipo II, Danlí, El Paraiso, Honduras

    Directory of Open Access Journals (Sweden)

    Raul O. Figueroa

    2017-03-01

    Full Text Available La presente investigación posee un enfoque cuantitativo con alcance correlacional de carácter experimental (cuasi-experimento la cual se refirió a los ejercicios físicos, los cuales son considerados muy beneficiosos para los pacientes aquejados de diabetes mellitus tipo 2, constituyéndose en uno de los pilares fundamentales en el tratamiento de esta enfermedad. Esta problemática no es ajena a los pacientes que asisten al HRGA y al IHSS de la ciudad de Danlí, Honduras, los cuales según el diagnóstico ejecutado a los efectos de esta investigación, se pudo comprobar afectaciones de control metabólico. El objetivo fue analizar los resultados de la aplicación de un programa de ejercicios físicos y educación diabetológica para mejorar el control metabólico y la calidad de vida de los pacientes. La muestra seleccionada es no probabilística por cuota, algunos criterios para su selección se pusieron de manifiesto y consta de 30 personas del IHSS y 30 personas del HRGA. En el estudio se utilizaron planteamientos hipotéticos de corte causal. La aplicación del programa de ejercicios contribuyó en gran medida a mejorar la calidad de vida de los pacientes del grupo experimental en comparación al grupo control tanto en lo físico, médico, psicológico y educacional. Generando una la relación de HDL con el LDL la cual es adecuada con respecto a la probabilidad que presenta que es de 0.5629 manifestando que el que se someta al Programa ya referido, disminuye el riesgo coronario.

  3. Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients

    DEFF Research Database (Denmark)

    Vestergaard, H; Bjørbaek, C; Hansen, T

    1995-01-01

    -phosphate concentrations in muscle have been found in non-insulin-dependent diabetes mellitus (NIDDM) patients when examined during a hyperglycemic hyperinsulinemic clamp. These findings [correction of finding] are consistent with a defect in glucose transport and/or phosphorylation. In the present study...

  4. Effectiveness of angiotensin II receptor antagonists in a cohort of Dutch patients with type 2 diabetes mellitus (ZODIAC-14).

    Science.gov (United States)

    van Hateren, Kornelis J J; Landman, Gijs W D; Groenier, Klaas H; Bilo, Henk J G; Kleefstra, Nanne

    2015-04-01

    There is limited evidence with respect to the between-group effects of various angiotensin receptor blockers (ARBs) on blood pressure and albuminuria in patients with type 2 diabetes mellitus. Therefore, we aimed to investigate the effects of differing ARBs on systolic blood pressure (SBP) and the albumin-creatinine ratio after 1 year in a large cohort of patients with type 2 diabetes mellitus. In 2007, 24 940 primary care patients with type 2 diabetes mellitus participated in the Zwolle Outpatient Diabetes project Integrating Available Care (ZODIAC) study, a prospective observational cohort study. Patients were included in the current study if they were prescribed an ARB in 2007 and if 1-year follow-up data were available. The final study population comprised 3610 patients. Multivariate mixed-model analyses were performed to estimate effects of the various ARBs on SBP and albuminuria. Stratified subgroup analyses were performed according to baseline hypertension and albuminuria. SBP decreased in all groups, the largest decrease being observed in the group receiving telmisartan. No significant or relevant changes over time were observed among groups for SBP and albuminuria. In the subgroup (n=1225) of normotensive patients, telmisartan was associated with a larger decrease in SBP after 1 year compared to other ARBs, without different effects on the albumin-creatinine ratio. We observed no differences in effects on SBP and the albumin-creatinine ratio among differing ARBs in patients with type 2 diabetes mellitus. Copyright © 2015 Canadian Diabetes Association. Published by Elsevier Inc. All rights reserved.

  5. TIPOS DE DISCURSO

    OpenAIRE

    Garcia, Afrânio; UERJ

    2012-01-01

    O professor Adilson Citelli, em seu excelente livro Linguageme persuasão, apresenta cinco tipos de discurso:§ discurso dominante§ discurso autorizado§ discurso polêmico,§ discurso lúdico§ discurso autoritário.

  6. RELACIÓN DE LOS NIVELES SÉRICOS DE LÍPIDOS Y LIPOPROTEÍNAS CON EL POLIMORFISMO ε 2, ε 3 Y ε 4 DEL GEN DE LA APOLIPOPROTEÍNA E, EN INDIVIDUOS CON DIABETES MELLITUS TIPO 2 Y EL RIESGO CARDIOVASCULAR

    Directory of Open Access Journals (Sweden)

    N. Coiza-Vargas

    2005-12-01

    Full Text Available Este trabajo describe la respuesta del perfil lipídico según el genotipo de la apolipoproteína E en personas con diabetes mellitus tipo 2 y la presencia o no de riesgo cardiovascular, por medio de la revisión sistemática de artículos científicos publicados entre 1990 y 2003. Seis estudios cumplieron con los criterios de inclusión y fueron seleccionados para realizar el trabajo de investigación.Inicialmente se realizó una descripción de características generales de los estudios y se utilizó la prueba estadística Chi - cuadrado para determinar diferencias entre grupos. Se encontró que el 66.6% de los artículos fueron realizados en Europa, el promedio de personas de los estudios fue de 473 y el promedio de edad estuvo en los 58 años.La distribución del genotipo E 3/3 (78.2%, fue la de mayor prevalencia en los diferentes grupos de diabéticos, seguido de E 4/3 en 12.8% y E 3/2 con un 8.7%. Las fracciones lipídicas más elevadas en los estudios fueron las de colesterol total, colesterol LDL y triglicéridos. Se observó que el polimorfismo de la apo E influye sobre el perfil lipídico, y por tanto, en el desarrollo de la enfermedad cardiovascular en los sujetos con DM tipo 2.

  7. Prevalência de fatores de risco de natureza modificável para a ocorrência de diabetes mellitus tipo 2 Predominio de factores de riesgo posibles de modificar en el acontecimiento de diabetes tipo 2 Prevalence of risk factors that can be modified into the occurrence of type 2 diabetes

    Directory of Open Access Journals (Sweden)

    Rosa Maria Fernandes Vilarinho

    2008-09-01

    Full Text Available Estudo transversal realizado com estudantes universitários do curso de Enfermagem para identificação de fatores de risco para o diabetes tipo 2. Em relação ao nível de risco: 65% apresentavam risco baixo, 27%, risco zero, enquanto 7,5% exibiam risco alto. A história familiar de diabetes e hipertensão foi identificada em 45% da amostra. A prevalência de sedentarismo foi igual a 75%; de sobrepeso, igual a 15%, e de obesidade (IMC e ³25 kg/m², igual a 5%. Verificaram-se ainda um menor consumo de alimentos ricos em fibras e o aumento do consumo de alimentos ricos em gorduras. Os dados levantados apontaram para a necessidade de investimentos em ações de promoção à saúde dentro da própria unidade de formação, como a criação de espaços próprios destinados à valorização da aquisição de novas práticas de saúde, através da ênfase à prática da atividade física, e incentivo à aquisição de hábitos alimentares saudáveis.El estudio enfadado realizado cerca de estudiantes de universidad del curso de enfermería, para la identificación de factores del riesgo para la diabetes tipo 2. En cuanto al nivel de riesgo: el 65 % presentaba bajo el riesgo, el 27 % marco el cero, mientras el 7,5 % mostraba el riesgo alto. La historia cerca de diabetes y hipertensión fue identificada en el 45 % de la muestra. El predominio de: el sedentarismo era el mismo al 75 %; de la sobrecarga igual al 15 %, y de la obesidad (CMI e" 25 kg/m2 igualan al 5 %. Menos consumo de la comida rica pasó todavía en fibras y el aumento del consumo de la comida rica en grasa. Los datos levantados señalaran la necesidad de inversiones en acciones de promoción a la salud dentro de la misma unidad de formación, como la creación de propios espacios destinados, el aumento del valor de la adquisición de nuevas prácticas de la salud, por el énfasis la práctica de la actividad física y incentivo a la adquisición de alimenticios saludables.Cross study

  8. Enhanced escape of non-esterified fatty acids from tissue uptake : its role in impaired insulin-induced lowering of total rate of appearance in obesity and Type II diabetes mellitus

    NARCIS (Netherlands)

    Riemens, SC; Sluiter, WJ; Dullaart, RPF

    Aims/hypothesis. To estimate non-esterified fatty acids kinetics in patients with Type II (non-insulin-dependent) diabetes mellitus and obese subjects in the postabsorptive state and during hyperinsulinaemia using non-equlibrium tracer conditions. Methods. We evaluated the effect of

  9. Coronary Heart Disease in Postmenopausal Women with Type II Diabetes Mellitus and the Impact of Estrogen Replacement Therapy: A Narrative Review

    Directory of Open Access Journals (Sweden)

    Marouane Boukhris

    2014-01-01

    Full Text Available Coronary heart disease is the main cause of death in postmenopausal women (PMW; moreover its mortality exceeds those for breast cancer in women at all ages. Type II diabetes mellitus is a major cardiovascular risk factor and there is some evidence that the risk conferred by diabetes is greater in women than in men. It was established that the deficiency of endogenous estrogens promotes the atherosclerosis process. However, the impact of estrogen replacement therapy (ERT on cardiovascular prevention remains controversial. Some authors strongly recommend it, whereas others revealed a concerning trend toward harm. This review tries to underlines the different components of cardiovascular risk in diabetic PMW and to define the place of ERT.

  10. To determine whether first-degree male relatives of women with polycystic ovary syndrome are at higher risk of developing cardiovascular disease and type II diabetes mellitus.

    Science.gov (United States)

    Hunter, A; Vimplis, S; Sharma, A; Eid, N; Atiomo, W

    2007-08-01

    The aim of this study was to determine whether first-degree male relatives of women with polycystic ovary syndrome (PCOS) were at increased risk of cardiovascular disease (CVD) and diabetes mellitus (type II DM). In a cross-sectional study, 60 women with PCOS and 112 controls were given a questionnaire. The prevalence of heart disease, stroke, diabetes and associated risk factors among fathers and brothers of women with PCOS and controls, were measured. The percentage of women with PCOS with at least one brother with a risk factor for CVD was 47.5%, around twice that seen in control women (24.71%). The prevalence of heart disease, stroke and diabetes were similar in brothers of women with PCOS and controls. In conclusion, brothers of women with PCOS may be at increased risk of CVD. They form an easily identified group, which can be targeted for primary prevention.

  11. Exercise and cognitive function: a hypothesis for the association of type II diabetes mellitus and Alzheimer's disease from an evolutionary perspective

    Directory of Open Access Journals (Sweden)

    Brito Gilberto NO

    2009-09-01

    Full Text Available Abstract The association of type II diabetes mellitus (DM2 with Alzheimer's disease (AD has received considerable attention in recent years. In the present paper, a hypothesis for this association from an evolutionary perspective, with emphasis on the close interplay between exercise and cognitive function, will be advanced in order to provide a biological rationale for the notion that the fundamental metabolic features of DM2 act in the brain over a protracted time span to induce the neuropathological characteristics of Alzheimer's disease thereby producing cognitive impairment. It is hoped that this hypothesis puts the association of DM2 and AD on firm conceptual grounds from a biological perspective and offers directions for further research.

  12. A Systematic Review: Family Support Integrated with Diabetes Self-Management among Uncontrolled Type II Diabetes Mellitus Patients

    Directory of Open Access Journals (Sweden)

    Rian Adi Pamungkas

    2017-09-01

    Full Text Available The rate of type-2 diabetes mellitus (T2D is dramatically increasing worldwide. Continuing diabetes mellitus (DM care needs effective self-management education and support for both patients and family members. This study aimed to review and describe the impacts of diabetes mellitus self-management education (DSME that involve family members on patient outcomes related to patient health behaviors and perceived self-efficacy on self-management such as medication adherence, blood glucose monitoring, diet and exercise changes, health outcomes including psychological well-being and self-efficacy, and physiological markers including body mass index, level of blood pressure, cholesterol level and glycemic control. Three databases, PubMed, CINAHL, and Scopus were reviewed for relevant articles. The search terms were “type 2 diabetes,” “self-management,” “diabetes self-management education (DSME,” “family support,” “social support,” and “uncontrolled glycaemia.” Joanna Briggs Institute (JBI guidelines were used to determine which studies to include in the review. Details of the family support components of DSME intervention and the impacts of these interventions had on improving the health outcomes patients with uncontrolled glycaemia patients. A total of 22 intervention studies were identified. These studies involved different DSME strategies, different components of family support provided, and different health outcomes to be measured among T2D patients. Overall, family support had a positive impact on healthy diet, increased perceived support, higher self-efficacy, improved psychological well-being and better glycemic control. This systematic review found evidence that DSME with family support improved self-management behaviors and health outcomes among uncontrolled glycaemia T2D patients. The findings suggest DSME models that include family engagement can be a useful direction for improving diabetes care.

  13. A Systematic Review: Family Support Integrated with Diabetes Self-Management among Uncontrolled Type II Diabetes Mellitus Patients.

    Science.gov (United States)

    Pamungkas, Rian Adi; Chamroonsawasdi, Kanittha; Vatanasomboon, Paranee

    2017-09-15

    The rate of type-2 diabetes mellitus (T2D) is dramatically increasing worldwide. Continuing diabetes mellitus (DM) care needs effective self-management education and support for both patients and family members. This study aimed to review and describe the impacts of diabetes mellitus self-management education (DSME) that involve family members on patient outcomes related to patient health behaviors and perceived self-efficacy on self-management such as medication adherence, blood glucose monitoring, diet and exercise changes, health outcomes including psychological well-being and self-efficacy, and physiological markers including body mass index, level of blood pressure, cholesterol level and glycemic control. Three databases, PubMed, CINAHL, and Scopus were reviewed for relevant articles. The search terms were "type 2 diabetes," "self-management," "diabetes self-management education (DSME)," "family support," "social support," and "uncontrolled glycaemia." Joanna Briggs Institute (JBI) guidelines were used to determine which studies to include in the review. Details of the family support components of DSME intervention and the impacts of these interventions had on improving the health outcomes patients with uncontrolled glycaemia patients. A total of 22 intervention studies were identified. These studies involved different DSME strategies, different components of family support provided, and different health outcomes to be measured among T2D patients. Overall, family support had a positive impact on healthy diet, increased perceived support, higher self-efficacy, improved psychological well-being and better glycemic control. This systematic review found evidence that DSME with family support improved self-management behaviors and health outcomes among uncontrolled glycaemia T2D patients. The findings suggest DSME models that include family engagement can be a useful direction for improving diabetes care.

  14. The effect of xerostomia and hyposalivation on the quality of life of patients with type II diabetes mellitus.

    Science.gov (United States)

    Molania, Tahereh; Alimohammadi, Mona; Akha, Ozra; Mousavi, Jaber; Razvini, Ramin; Salehi, Maedeh

    2017-11-01

    Diabetes mellitus is a chronic metabolic disease which can have numerous physical effects for patient. Xerostomia is one of these complications. Compared to healthy people, patients with diabetes mellitus, have a worse quality of life, and complications of diabetes are the main determinants of quality of life in these patients. The aim of this study was to determine the effects of xerostomia and hyposalivation on quality of life of patients with type 2 diabetes mellitus. This descriptive-analytical epidemiological study was conducted on 200 patients with type 2 diabetes mellitus referred to the diabetes clinic of Shahid Mostafavi in Sari city from October 2015 to January in 2016. A questionnaire containing personal characteristics and medical situation was completed by each person. Then, the Persian Oral Health Impact Profile-14 (OHIP-14-PER) questionnaire was completed by the patients. Eventually, with the use of chewable paraffin for 1.5 min by the patient, stimulated salivary flow rate (SSFR) test was performed, and in order to determine hyposalivation, their saliva amount underwent a gravimetric test. Finally, using statistical software SPSS16, the information was statistically analyzed by independent-samples t-test, Mann-Whitney U, Chi-squared and fisher exact tests. The average age of patient was 56.41 years old (43% male and 57% female). Mean SSFR was 0.7 ml/min in patients and xerostomia were confirmed in 112 patients. Difference between age, gender, drug use, years affecting to diabetes and FBS amount in patient with hyposalivation were not statistically meaningful in proportion to patients without it. But difference between HbA1C and SSFR in patients with hyposalivation were statistically meaningful than to patients without it (p=0.03, p=0.001 respectively). The mean patient score to OHIP-14 were obtained as 38.17. The questionnaire score difference in patients with hyposalivation in proportion to patients without it were not statistically meaningful

  15. SEROLOGICAL MARKERS OF CELIAC DISEASE AND HLA II ANTIGENS IN CHILDREN AND ADOLESCENTS WITH DIABETES MELLITUS TYPE 1

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    E. O. Hennesy

    2012-01-01

    Full Text Available We have studied incidenceof immunological markers of celiac disease in children with diabetes mellitus type 1 (DM1 and their correlation with clinical peculiarities and polymorphous alleles of HLA. It was shown that incidence of celiac markers is higher in DM1 children than in general population and makes up 7.4%. Patients who were seropositive with celiac antigens had gastrointestinal symptoms and iron deficiency more often. The occurrence rate of other autoimmune disorders in seropositive patients was 24%, with high count of autoantibodies towards transglutaminase (AbTT — 50%. More than 78% of seroposetive patients possessed haplotypes DQ2 and|or DQ8 HLA. The occurrence rate was identical. In patients with high AbTT occurrence of HLA genotypes with DQ2 and/or DQ8 rose up to 100%.

  16. Factors Associated with Participation in Pulmonary Tuberculosis Screening Using Chest X-Ray among Diabetes Mellitus Type II Patients in Denpasar, Bali, Indonesia.

    Science.gov (United States)

    Putra, I Gusti Ngurah Edi; Astuti, Putu Ayu Swandewi; Suarjana, I Ketut; Mulyawan, Ketut Hari; Duana, I Made Kerta; Kurniasari, Ni Made Dian; Putra, I Wayan Gede Artawan Eka

    2018-01-01

    Diabetes mellitus (DM) increases the risk of developing pulmonary tuberculosis (TB) disease. Therefore, pulmonary TB screening among DM patients is essential. This study aimed to identify factors associated with participation of DM type II patients in pulmonary TB screening using chest X-ray. This was a cross-sectional analytic study and was part of TB-DM screening study in Denpasar, Bali, Indonesia. The sample consisted of 365 DM type II patients selected by quota sampling among DM type II patients joining the screening program from January until March 2016 in 11 public health centres in Denpasar. Data were collected via structured interviews. The contributing factors were determined by modified Poisson regression test for cross-sectional data. From the findings, less than half (45.48%) of DM type II patients participated in chest X-ray examination for TB. Factors associated with participation in pulmonary TB screening were having a higher educational level [APR = 1.34, 95% CI (1.07-1.67)], having family member who developed pulmonary TB disease [APR = 1.47, 95% CI (1.12-1.93)], the travel time to referral hospital for screening being ≤ 15 minutes [APR = 1.6, 95% CI (1.26-2.03)], having health insurance [APR = 2.69, 95% CI (1.10-6.56)], and receiving good support from health provider [APR = 1.35, 95% CI (1.06-1.70)]. Therefore, training for health provider on providing counselling, involvement of family members in screening process, and improving the health insurance coverage and referral system are worth considering.

  17. Polymorphism AvaII of the LDL receptor (rs5925 is associated with carotid-intima media thickness in patients with diabetes mellitus type 2

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    Jovana Nikolajević-Starčević

    2014-08-01

    Full Text Available Introduction Increased serum level of low density lipoprotein (LDL cholesterol is a well established risk factor for atherosclerosis development and progression. Genetic variation in the LDL receptor gene could modulate serum LDL level and response to statin treatment thus affecting atherosclerosis development and progression. The present study was designed to investigate the association between polymorphism AvaII (rs5925 of the LDL receptor gene with serum lipid levels and carotid intima-media thickness (CIMT in patients with diabetes mellitus type 2 (DM2.Methods 595 patients with DM2 (399 on statin therapy and 196 without were enrolled in the study. The carotid intima-media thickness was assessed ultrasonographically. Biochemical analyses were performed using standard biochemical methods. AvaII (rs5925 genotypes were determined by real-time PCR. Results Genotype distribution and allele frequencies were not statistically significantly different between DM2 patients with regard to statin therapy. In DM2 patients using statins the highest serum levels of total and LDL cholesterol were observed in homozygous carriers of the A+ allele. After adjustment for well established cardiovascular risk factors homozygosity for the A+ allele (β=0.441 and p=0.04, statin treatment as well as serum levels of HDL, triglycerides, hsCRP and fibrinogen were independently associated with CIMT. Interactions of AvaII genotypes A-A+ and A+A+ with statin treatment were not statistically significant.Conclusion Homozigosity for the A+ allele of the AvaII polymorphism is associated with greater CIMT in DM2 patients.

  18. Factors Associated with Participation in Pulmonary Tuberculosis Screening Using Chest X-Ray among Diabetes Mellitus Type II Patients in Denpasar, Bali, Indonesia

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    I Gusti Ngurah Edi Putra

    2018-01-01

    Full Text Available Diabetes mellitus (DM increases the risk of developing pulmonary tuberculosis (TB disease. Therefore, pulmonary TB screening among DM patients is essential. This study aimed to identify factors associated with participation of DM type II patients in pulmonary TB screening using chest X-ray. This was a cross-sectional analytic study and was part of TB-DM screening study in Denpasar, Bali, Indonesia. The sample consisted of 365 DM type II patients selected by quota sampling among DM type II patients joining the screening program from January until March 2016 in 11 public health centres in Denpasar. Data were collected via structured interviews. The contributing factors were determined by modified Poisson regression test for cross-sectional data. From the findings, less than half (45.48% of DM type II patients participated in chest X-ray examination for TB. Factors associated with participation in pulmonary TB screening were having a higher educational level [APR = 1.34, 95% CI (1.07–1.67], having family member who developed pulmonary TB disease [APR = 1.47, 95% CI (1.12–1.93], the travel time to referral hospital for screening being ≤ 15 minutes [APR = 1.6, 95% CI (1.26–2.03], having health insurance [APR = 2.69, 95% CI (1.10–6.56], and receiving good support from health provider [APR = 1.35, 95% CI (1.06–1.70]. Therefore, training for health provider on providing counselling, involvement of family members in screening process, and improving the health insurance coverage and referral system are worth considering.

  19. Procesos metalúrgicos de aceros microaleados de alta resistencia 450 EMZ tipo II en la zona afectada térmicamente debido al efecto multipasada en soldaduras por arco sumergido

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    González-Palma, R.

    2006-08-01

    Full Text Available A considerable number of crack tip opening displacement tests in the heat affected zone (HAZ of multipass welds, performed in accordance with standards BS 5762 and EEMUA, are rejected since the crack is not inside the coarse grain region at 0.5 mm from the fusion border, as well as the quantity of the crack length in percentage, that the crack goes through the intercritical region instead of in the grain coarse region as it would correspond. This circumstance make advisable to carry out a metallographic study of the intercritical zone in the HAZ as well as the corresponding tests, in order analyze the intercritical region brittleness reasons. The study is performed on a HSLA 75 mm thick panel 450 EMZ type II, welded under a SAW process with heat input and welded parameters controlled, without any post weld heat treatment

    La falta de cumplimiento de las normas BS 5762 y EEMUA, en considerables casos, invalida los ensayos de mecánica de la fractura, al no encontrarse la grieta en la región de grano grueso a 0,5 mm de la línea de fusión, así como en la cantidad expresada en porcentaje de longitud de grieta que atraviesa la región intercrítica, en lugar de hacerlo en la región de grano grueso. Esta circunstancia, conduce a realizar un estudio metalográfico de dicha región intercrítica de la zona afectada térmicamente así como los correspondientes ensayos, con objeto de analizar las causas de su fragilidad. Este estudio se realiza sobre un panel de chapa de acero microaleado de alto límite elástico, calidad EMZ 450 tipo II, de 75 mm de espesor, soldado bajo un proceso por arco sumergido, con energía calorífica aportada y parámetros de soldadura controlados, sin tratamiento térmico post-soldeo.

  20. Espiritualidad e incertidumbre ante la enfermedad: adultos diabéticos tipo 2

    OpenAIRE

    Gómez Palencia, Isabel Patricia; Durán de Villalobos, María Mercedes

    2013-01-01

    El objetivo principal de este artículo es determinar la relación entre espiritualidad e incertidumbre presente en personas con situación crónica por diabetes mellitus tipo 2 en instituciones de servicio de salud en Cartagena, Colombia. El estudio fue realizado con un método descriptivo transversal, correlacional.Asimismo, la muestra fue de 163 pacientes que tuvieran como mínimo dos meses de haber sido diagnosticados con diabetes mellitus tipo 2; los instrumentos utilizados fueron la escala de...

  1. A importância do teste de tolerância à glicose oral no diagnóstico da intolerância à glicose e diabetes mellitus do tipo 2 em mulheres com síndrome dos ovários policísticos The importance of oral glucose tolerance test in diagnosis of glucose intolerance and type 2 diabetes mellitus in women with polycystic ovary syndrome

    Directory of Open Access Journals (Sweden)

    Ana Gabriela Pontes

    2012-03-01

    Full Text Available OBJETIVO: Avaliar a importância do teste de tolerância à glicose oral (TTGO no diagnóstico da intolerância à glicose (IG e diabetes mellitus do tipo 2 (DM-2 em mulheres com SOP. MÉTODOS: Estudo retrospectivo em que foram incluídas 247 pacientes portadoras de SOP, selecionadas de forma aleatória. O diagnóstico de IG foi obtido por meio do TTGO de duas horas com 75 gramas de glicose de acordo com os critérios do World Health Organization (WHO (IG: glicemia plasmática aos 120 minutos >140 mg/dL e 200 mg/dL quanto pela glicemia de jejum segundo os critérios da American Diabetes Association (glicemia de jejum alterada: glicemia plasmática >100 e 126 mg/dL. Para comparar o TTGO com a glicemia de jejum foi aplicado o modelo de regressão logística para medidas repetidas. Para a análise das características clínicas e bioquímicas das pacientes com e sem IG e/ou DM-2 foi utilizada a ANOVA seguida do teste de Tukey. O valor pPURPOSE: To evaluate the importance of the oral glucose tolerance test for the diagnosis of glucose intolerance (GI and type 2 diabetes mellitus (DM-2 in women with PCOS. METHODS: A retrospective study was conducted on 247 patients with PCOS selected at random. The diagnosis of GI was obtained from the two-hour oral glucose tolerance test with 75 g of glucose according to the criteria of the World Health Organization (WHO (GI: 120 minutes for plasma glucose >140 mg/dL and 200 mg/dL and fasting glucose using the criteria of the American Diabetes Association (impaired fasting glucose: fasting plasma glucose >100 and 126 mg/dL. A logistic regression model for repeated measures was applied to compare the oral glucose tolerance test with fasting plasma glucose. ANOVA followed by the Tukey test was used for the analysis of the clinical and biochemical characteristics of patients with and without GI and/or DM-2. A p<0.05 was considered statistically significant. RESULTS: PCOS patients had a mean age of 24.8±6.3, and body

  2. Treatments for diabetes mellitus type II: New perspectives regarding the possible role of calcium and cAMP interaction.

    Science.gov (United States)

    Carvalho, Diego Soares; de Almeida, Alexandre Aparecido; Borges, Aurélio Ferreira; Campos, Vannucci

    2018-07-05

    Diabetes mellitus (DM) is among the top ten causes of death worldwide. It is considered to be one of the major global epidemics of the 21st century, with a significant impact on public health budgets. DM is a metabolic disorder with multiple etiologies. Its pathophysiology is marked by dysfunction of pancreatic β-cells which compromises the synthesis and secretion of insulin along with resistance to insulin action in peripheral tissues (muscle and adipose). Subjects presenting insulin resistance in DM type 2 often also exhibit increased insulin secretion and hyperinsulinemia. Insulin secretion is controlled by several factors such as nutrients, hormones, and neural factors. Exocytosis of insulin granules has, as its main stimulus, increased intracellular calcium ([Ca +2 ]i) and it is further amplified by cyclic AMP (cAMP). In the event of this hyperfunction, it is very common for β-cells to go into exhaustion leading to failure or death. Several animal studies have demonstrated pleiotropic effects of L-type Ca 2+ channel blockers (CCBs). In animal models of obesity and diabetes, treatment with CCBs promoted restoration of insulin secretion, glycemic control, and reduction of pancreatic β-cell apoptosis. In addition, hypertensive individuals treated with CCBs presented a lower incidence of DM when compared with other antihypertensive agents. In this review, we propose that pharmacological manipulation of the Ca 2+ /cAMP interaction system could lead to important targets for pharmacological improvement of insulin secretion in DM type 2. Copyright © 2018 Elsevier B.V. All rights reserved.

  3. Analysis of Gln223Agr Polymorphism of Leptin Receptor Gene in Type II Diabetic Mellitus Subjects among Malaysians

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    Chong Pei Pei

    2013-09-01

    Full Text Available Leptin is known as the adipose peptide hormone. It plays an important role in the regulation of body fat and inhibits food intake by its action. Moreover, it is believed that leptin level deductions might be the cause of obesity and may play an important role in the development of Type 2 Diabetes Mellitus (T2DM, as well as in cardiovascular diseases (CVD. The Leptin Receptor (LEPR gene and its polymorphisms have not been extensively studied in relation to the T2DM and its complications in various populations. In this study, we have determined the association of Gln223Agr loci of LEPR gene in three ethnic groups of Malaysia, namely: Malays, Chinese and Indians. A total of 284 T2DM subjects and 281 healthy individuals were recruited based on International Diabetes Federation (IDF criteria. Genomic DNA was extracted from the buccal specimens of the subjects. The commercial polymerase chain reaction (PCR method was carried out by proper restriction enzyme MSP I to both amplify and digest the Gln223Agr polymorphism. The p-value among the three studied races was 0.057, 0.011 and 0.095, respectively. The values such as age, WHR, FPG, HbA1C, LDL, HDL, Chol and Family History were significantly different among the subjects with Gln223Agr polymorphism of LEPR (p < 0.05.

  4. Analysis of Gln223Agr polymorphism of Leptin Receptor Gene in type II diabetic mellitus subjects among Malaysians.

    Science.gov (United States)

    Etemad, Ali; Ramachandran, Vasudevan; Pishva, Seyyed Reza; Heidari, Farzad; Aziz, Ahmad Fazli Abdul; Yusof, Ahmad Khairuddin Mohamed; Pei, Chong Pei; Ismail, Patimah

    2013-09-18

    Leptin is known as the adipose peptide hormone. It plays an important role in the regulation of body fat and inhibits food intake by its action. Moreover, it is believed that leptin level deductions might be the cause of obesity and may play an important role in the development of Type 2 Diabetes Mellitus (T2DM), as well as in cardiovascular diseases (CVD). The Leptin Receptor (LEPR) gene and its polymorphisms have not been extensively studied in relation to the T2DM and its complications in various populations. In this study, we have determined the association of Gln223Agr loci of LEPR gene in three ethnic groups of Malaysia, namely: Malays, Chinese and Indians. A total of 284 T2DM subjects and 281 healthy individuals were recruited based on International Diabetes Federation (IDF) criteria. Genomic DNA was extracted from the buccal specimens of the subjects. The commercial polymerase chain reaction (PCR) method was carried out by proper restriction enzyme MSP I to both amplify and digest the Gln223Agr polymorphism. The p-value among the three studied races was 0.057, 0.011 and 0.095, respectively. The values such as age, WHR, FPG, HbA1C, LDL, HDL, Chol and Family History were significantly different among the subjects with Gln223Agr polymorphism of LEPR (p < 0.05).

  5. Influência da adequação postural em cadeira de rodas na função respiratória de pacientes com amiotrofia espinhal tipo II Influence of wheelchair positioning aids on the respiratory function of patients with type II spinal muscular atrophy

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    Luanda André Collange

    2009-09-01

    Full Text Available Este estudo visou determinar a influência da adequação postural em cadeira de rodas na função respiratória de pacientes com amiotrofia espinhal tipo II (AME. Doze pacientes (idades entre 7 e 24 anos com diagnóstico de AME II, confirmado por achados clínicos e análise genética, participaram do estudo. Os parâmetros respiratórios - volume minuto (VM, volume corrente (VC, capacidade vital forçada (CVF, pressões inspiratória (PImáx e expiratória (PEmáx máximas e pico de fluxo expiratório (PFE - na cadeira de rodas individual, com adaptações, e em uma cadeira de rodas padrão, isto é, sem reclinação ou inclinação. Os resultados mostram valores melhores estatisticamente significativos de todos os parâmetros respiratórios (VM, p=0,002; VC, p=0,003; CVF, p=0,017; PImáx, p=0,002; PEmáx, p=0,006; e PFE, p=0,007 nas medidas tomadas na cadeira adaptada para a postura adequada. Os resultados permitem concluir que a adequação postural em cadeira de rodas influencia positivamente a função respiratória de pacientes com AME tipo II.This study aimed at determining the influence of adequate wheelchair positioning aids on the respiratory function in spinal muscular atrophy (SMA type II patients. Twelve patients (aged 7 to 24 with SMA diagnosed by clinical findings and confirmed by genetic analysis, who owned wheelchairs with positioning aids, underwent spirometric assessment - as to minute volume (MV, tidal volume (TV, forced vital capacity (FVC, maximum inspiratory (IPmax and expiratory (EPmax pressures, and peak expiratory flow (PEF - both on their own wheelchair and on a standard wheelchair with no recline or tilt. Results show significantly better values in all assessed parameters (MV, p=0.002; TV, p=0.003; FVC, p=0.017; IPmax, p=0.002, EPmax, p=0.006; and PEF, p=0.007 of measures taken at the patient's own chair, with positioning aids. These results allow for concluding that wheelchair positioning aids may positively

  6. Association of Barrett's esophagus with type II Diabetes Mellitus: results from a large population-based case-control study.

    Science.gov (United States)

    Iyer, Prasad G; Borah, Bijan J; Heien, Herbert C; Das, Ananya; Cooper, Gregory S; Chak, Amitabh

    2013-09-01

    Central obesity could increase the risk for Barrett's esophagus (BE) and esophageal adenocarcinoma by mechanical and/or metabolic mechanisms, such as hyperinsulinemia. We performed an epidemiologic study to determine whether prior type 2 diabetes mellitus (DM2) is associated with BE. We performed a population-based case-control study using the General Practice Research Database, a UK primary care database that contains information on more than 8 million subjects, to identify cases of BE (using previously validated codes; n = 14,245) and matched controls without BE (by age, sex, enrollment date, duration of follow-up evaluation, and practice region by incidence density sampling; n = 70,361). We assessed the association of a prior diagnosis of DM2 with BE using conditional univariate and multivariable regression analysis. Confounders assessed included smoking, obesity measured by body mass index (BMI), and gastroesophageal reflux disease. BE cases were more likely than controls to have smoked (52.4% vs 49.9%), have a higher mean BMI (27.2 vs 26.9), and a higher prevalence of DM2 than controls (5.8% vs 5.3%). On multivariable analysis, DM2 was associated with a 49% increase in the risk of BE, independent of other known risk factors (odds ratio, 1.49; 95% confidence interval, 1.16-1.91). This association was stronger in women than men. Results remained stable with sensitivity analyses. In a large population-based case-control study, DM2 was a risk factor for BE, independent of obesity (as measured by BMI) and other risk factors (smoking and gastroesophageal reflux disease). These data suggest that metabolic pathways related to DM2 should be explored in BE pathogenesis and esophageal carcinogenesis. Copyright © 2013 AGA Institute. Published by Elsevier Inc. All rights reserved.

  7. Analytical Evaluation to Determine Selected PAHs in a Contaminated Soil With Type II Fuel; Metodo Optimizado de Extraccion por Ultrasonidos para la Determinacion de PAHs Seleccionados en un Suelo Contaminado con Fuel de Tipo II

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Alonso, S.; Perez Pastor, R. M.; Sevillano Castano, M. L.; Garcia Frutos, F. J.

    2010-10-21

    A study on the optimization of an ultrasonic extraction method for selected PAHs determination in soil contaminated by type II fuel and by using HPLC with fluorescence detector is presented. The main objective was optimize the analytical procedure, minimizing the volume of solvent and analysis time and avoiding possible loss by evaporation. This work was carried out as part of a project that investigated a remediation process of agricultural land affected by an accidental spillage of fuel (Plan Nacional I + D + i, CTM2007-64 537). The paper is structured as: Optimization of wavelengths in the chromatographic conditions to improve resolution in the analysis of fuel samples. Optimization of the main parameters affecting in the extraction process by sonication. Comparison of results with those obtained by accelerated solvent extraction. (Author) 3 refs.

  8. Riesgo coronario en pacientes con diabetes mellitus tipo 2

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    Andrés Eduardo Gallegos Cobo

    2017-09-01

    CONCLUSION: La estratificación del riesgo coronario elevado en pacientes con DM2 fueron frecuentes en este estudio comportándose de forma similar a otras casuísticas revisadas sobre este tema, repercutiendo de forma integral en la salud cardiovascular, ultimando hasta el momento no se ha implementado recomendaciones según estrategias en el servicio de Medicina Interna. Recomendando se realice estudios cuyo propósito es generar estrategias integrales para concientizar a los pacientes y al personal de salud sobre la necesidad de prevenir y controlar el riesgo coronario, y con ello disminuir los ingresos hospitalarios, costos económicos, las comorbilidades e incrementar la expectativa y calidad de vida de quienes la padecen.

  9. Redução fechada e fixação esquelética externa tipo II para o tratamento de fraturas de tibiotarso em pombos domésticos (Columba livia Closed reduction and type-II external skeletal fixation for treatment of tibiotarsus fractures in domestic pigeons (Columba livia

    Directory of Open Access Journals (Sweden)

    Marcelo Meller Alievi

    2001-12-01

    Full Text Available A redução fechada e o fixador esquelético externo tipo II foram avaliados para o tratamento de fraturas de tibiotarso em pombos domésticos (Columba livia. Foram utilizadas doze aves adultas. Os pombos foram anestesiados com a associação de xilazina e cetamina e, em seguida, foi realizada fratura do tibiotarso direito através de pressão digital sobre a diáfise do membro. Quatro pinos de Kirschner, dois proximais e dois distais ao foco da fratura, foram inseridos através de ambas as corticais ósseas e, após redução fechada da fratura, conectados externamente por duas barras de acrílico autopolimerizável, uma na face lateral e outra na face medial do membro. Em cinco aves, foi observado radiograficamente desvio ósseo angular, porém, a função do membro não foi afetada. O tempo médio e o desvio padrão para a cicatrização óssea foram 24,8 ± 4,89 dias. Os resultados demonstram que a redução fechada e o fixador esquelético externo tipo II são efetivos para o tratamento de fraturas de tibiotarso em pombos domésticos (Columba livia.The aim of this study was to evaluate the use of closed reduction and type-II external skeletal fixation for treatment of tibiotarsus fractures in domestic pigeons (Columba livia. Twelve adult domestic pigeons were used. Anesthesia was induced with xylazine and ketamine hydrochloride; the right tibiotarsus was manually fractured by digital pressure applied at the mid-diaphysis. Four Kirschner wires were placed through both cortices of the bone, two proximal and two distal to the fracture site, and, after closed reduction of the fracture, they were stabilized by two acrilic bars, one in the lateral and another in the medial surface of the tibiotarsus. Abnormalities in bone angulation were observed radiographically in five birds; however, the function of the limb was not noticeably impaired. The mean time ± standard deviation for fracture healing was 24.8 ± 4.89 days. The results of this

  10. Allele variants of HLA II genes DRB1 and DQB1 regarding risk for type 1 diabetes mellitus in population of Bashkortostan

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    Shamilevna Avzaletdinova

    2012-09-01

    Full Text Available Aims. To estimate significance of HLA II DRB1 and DRB2 allele variants for development of type 1 diabetes mellitus (T1DM in Bashkortostanpopulation (ethnical Russians, Tatar, Bashkir. Materials and methods. We analyzed DNA of 323 patients with T1DM and 683 healthy controls. DNA was derived from venous bloodsamples by phenol-chloroform extraction. DRB1 and DQB1 gene typing was performed by PCR method. Amplification products wereidentified with electrophoresis on a 1% agarose gel. Statistica for Windows v6.0 and MS Excel 98 software were applied for statisticalprocessing of acquired data. Results. Common markers of high risk for T1DM were found to be DRB1*04, DRB1*17, genotype DRB1*04/*17. On the contrary,lower risk was associated with DRB1*15 allele. In ethnical Russians lower risk of T1DM is also determined by DRB1*11 allele andDRB1*01 in Tatars. Predisposition by DQB1-alleles in Russians and Bashkir realizes only within DRB1*04/*17 genotype. However,in Tatar subpopulation DQB1*0302 is an independent risk marker of T1DM development. Conclusion. Common low risk markers for all three ethnic groups are DQB1*0301, DQB1*0602-08 alleles. Their presence negates riskof disease in all studied subpopulations even within DRB1*04/*17-genotype.

  11. Resistance Training in Type II Diabetes Mellitus: Impact on Areas of Metabolic Dysfunction in Skeletal Muscle and Potential Impact on Bone

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    Richard J. Wood

    2012-01-01

    Full Text Available The prevalence of Type II Diabetes mellitus (T2DM is increasing rapidly and will continue to be a major healthcare expenditure burden. As such, identification of effective lifestyle treatments is paramount. Skeletal muscle and bone display metabolic and functional disruption in T2DM. Skeletal muscle in T2DM is characterized by insulin resistance, impaired glycogen synthesis, impairments in mitochondria, and lipid accumulation. Bone quality in T2DM is decreased, potentially due to the effects of advanced glycation endproducts on collagen, impaired osteoblast activity, and lipid accumulation. Although exercise is widely recognized as an important component of treatment for T2DM, the focus has largely been on aerobic exercise. Emerging research suggests that resistance training (strength training may impose potent and unique benefits in T2DM. The purpose of this review is to examine the role of resistance training in treating the dysfunction in skeletal muscle and the potential role for resistance training in treating the associated dysfunction in bone.

  12. Development and standardization of radioimmunoassay technique for human proinsulin determining and its use in the study of type II diabetes mellitus associated to obesity

    International Nuclear Information System (INIS)

    Nascimento, Martha do

    1996-01-01

    The availability of immunoassay methodology for proinsulin is important to define its physiological and pathophysiological significance in humans. Serum concentration of proinsulin are elevated in patients with type II Diabetes Mellitus (NIDDM) and recently diagnosed Type I, so a raised circulating concentration of proinsulin may serve as an early indicator of β cells dysfunction. recently, in NIDDM the serum concentrations of proinsulin and its B-chain-C-peptide junctional split form, des (31-32), were found to correlate with diastolic blood pressure, a risk factor for cardiovascular disease. The development of a sensitive and specific radioimmunoassay (RIA) methodology for proinsulin has been difficult due to its low concentration in serum and the presence of proinsulin conversion intermediates in fluids and tissues. Also other potentially cross-reactive peptides, including insulin and C-peptide, can interfere in the assay. This work describe a highly specific human proinsulin RIA developed by using biosynthetic human proinsulin (hPI) as immunogen, standard and tracer. (author)

  13. Coadministration of alloxan and nicotinamide in rats produces biochemical changes in blood and pathological alterations comparable to the changes in type II diabetes mellitus.

    Science.gov (United States)

    Vattam, K K; Raghavendran, Hrb; Murali, M R; Savatey, H; Kamarul, T

    2016-08-01

    In the present study, thirty six male Sprague Dawley rats were randomly divided into six groups and were injected with varying doses of alloxan (Ax) and nicotinamide (NA). The serum levels of glucose, insulin, and adiponectin were measured weekly up to 4 weeks. Elevated levels of glucose were observed in all groups on days 7, 14, 21, and 28, except in groups a and f (control). The serum insulin levels were significantly elevated in groups b and c on day 7, when compared with that in group f, whereas a decrease in the serum insulin levels was observed in groups d and e on days 21 and 28. The adiponectin levels showed inconsistencies on days 7 and 14. However, significant decrease in the adiponectin levels was observed on days 21 and 28. Histological section of the pancreas showed mild (group a), moderate (group b) to severe (groups c, d, and e) degenerative changes. Concomitant fatty changes in the liver and inflammatory infiltration of the kidney were markedly observed in all the treated groups, when compared to control. These results suggested that the use of selective combination of Ax120 + NA50 injection demonstrated type II diabetes mellitus in rats. © The Author(s) 2015.

  14. Quality assessment of recent evidence-based clinical practice guidelines for management of type 2 diabetes mellitus in adults using the AGREE II instrument.

    Science.gov (United States)

    Anwer, Muhammad A; Al-Fahed, Ousama B; Arif, Samir I; Amer, Yasser S; Titi, Maher A; Al-Rukban, Mohammed O

    2018-02-01

    Type 2 diabetes mellitus (T2DM) is a worldwide and national public health problem that has a great impact on the population in Saudi Arabia. High-quality clinical practice guidelines (CPGs) are cornerstones in improving the health care provided for patients with diabetes. This study evaluated the methodological rigour, transparency, and applicability of recently published CPGs. Our group conducted a systematic search for recently published CPGs for T2DM. The searching and screening for Source CPGs were guided by tools from the ADAPTE methods with specific inclusion/exclusion criteria. Five reviewers using the second version of the Appraisal of Guidelines for Research and Evaluation (AGREE II) Instrument independently assessed the quality of the retrieved Source CPGs. Domains of Scope and purpose and Clarity of presentation received the highest scores in all CPGs. Most of the assessed CPGs (86%) were considered with high overall quality and were recommended for use. Rigour of development and applicability domains were together highest in 3 CPGs (43%). The overall high quality of DM CPGs published in the last 3 years demonstrated the continuous development and improvement in CPG methodologies and standards. Health care professionals should consider the quality of any CPG for T2DM before deciding to use it in their daily clinical practice. Three CPGs have been identified, using the AGREE criteria, as high-quality and trustworthy. Ideally, the resources provided by the AGREE trust including the AGREE II Instrument should be used by a clinician to scan through the large number of published T2DM CPGs to identify the CPGs with high methodological quality and applicability. © 2017 John Wiley & Sons, Ltd.

  15. Association of Traditional Chinese Medicine Therapy and the Risk of Vascular Complications in Patients With Type II Diabetes Mellitus

    Science.gov (United States)

    Lee, Ai-Lin; Chen, Bor-Chyuan; Mou, Chih-Hsin; Sun, Mao-Feng; Yen, Hung-Rong

    2016-01-01

    Abstract With an increasing use of traditional Chinese medicine (TCM) in type 2 diabetes mellitus (T2DM), evidence of long-term benefit with adjunctive TCM treatment is limited. This study investigated whether the concurrent TCM treatment reduces the risk of vascular complications in T2DM patients by using a large population from National Health Insurance Research Database (NHIRD). We identified 33,457 adult patients with newly diagnosed T2DM using anti-diabetic agents from a random sample of one million beneficiaries in the NHIRD between January 1, 2000 and December 31, 2011. We recruited 1049 TCM users (received TCM over 30 days with a diagnosis of T2DM) and randomly selected 4092 controls as the non-TCM cohort at a ratio of 1:4 frequency-matched by age, sex, hypertension, hyperlipidemia, and index year. We investigated the prescription pattern of TCM and conducted a Cox proportional hazards regression to calculate the hazard ratios (HRs) of stroke, chronic kidney diseases (CKD), and diabetic foot between the 2 cohorts. In the TCM cohort, the prescription pattern of TCM was different between insulin and noninsulin patients. The most common herbs were Dan-Shen (Radix Salviae Miltiorrhizae) in noninsulin group and Da-Huang (Radix et Rhizoma Rhei) in insulin group. The most common formulae were Liu-Wei-Di-Huang-Wan in noninsulin group and Yu-Quan-Wan in insulin group. Although no significant reduction in the hazard ratio of CKD and diabetic foot, the incidence rate of stroke was 7.19 per 1000 person-years in the TCM cohort and 10.66 per 1000 person-years in the control cohort, respectively. After adjustment of age, sex, hypertension, hyperlipidemia, and antidiabetes agent use (including sulfonylureas, α-glucosidase, metformin, meglitinide, thiazolidinediones, and insulin), TCM cohorts were found to have a 33% decreased risk of stroke (95% CI = 0.46–0.97; P < 0.05). This population-based retrospective study showed that the complementary TCM therapy might

  16. Apical Periodontitis and Endodontic Treatment in Patients with Type II Diabetes Mellitus: Comparative Cross-sectional Survey.

    Science.gov (United States)

    Smadi, Leena

    2017-05-01

    The aims of this study were to investigate the prevalence of apical periodontitis (AP) in diabetes mellitus (DM) patients compared with nondiabetic patients and to examine the effect of glycemic control on the prevalence of AP. Radiographs of a group of DM patients were compared with those of a matched nondiabetic group to identify AP. The diabetic group was subdivided according to the level of glycemic control into two subgroups: A well-controlled DM and a poorly controlled DM. The periapical index score was used to assess the periapical status. All groups were compared in regard to the presence of AP lesions, the number of end-odontically treated teeth (ET), and the percentage of failure of endodontically treated teeth (AP/ET ratio). Statistical Package for the Social Sciences (SPSS version 20.0, Chicago, Illinois, USA) was used for all the analyses; p ≤ 0.05 was considered as statistically significant. The prevalence of AP was higher in diabetic group than in the nondiabetic group (13.5 vs 11.9% respectively). Diabetic group had more teeth with endodontic treatment ET compared with nondiabetic group (4.18 vs 1.82% respectively); this difference was statistically significant (p = 0.001) along with higher AP/ET ratio (27.7 vs 19.3 respectively). The poorly controlled DM group had a higher prevalence of AP lesions compared with the well-controlled DM group (18.29 vs 9.21 respectively). This difference was statistically significant (p = 0.001); they also had a higher percentage of ET (5.55 vs 3.13% respectively) and AP/ ET ratio (32.0 vs 21.8% respectively). This survey demonstrates a higher prevalence of AP in DM patients compared with nondiabetic group, with an increased prevalence of persistent chronic AP. Compared with a well-controlled diabetic group, a poor glycemic control may be associated with a higher prevalence of AP and increased rate of endodontic failures. Counseling diabetic patients, particularly those with poor glycemic control, about the risk of

  17. Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: The DAMAGE study

    DEFF Research Database (Denmark)

    Reiling, Erwin; van Vliet-Ostaptchouk, Jana V; van 't Riet, Esther

    2009-01-01

    ). After a meta-analysis, only one SNP in SIRT4 (rs2522138) remained significant (P=0.01). Extending the second stage with samples from the Danish Steno Study (n=1220 participants) resulted in a common odds ratio (OR) of 0.92 (0.85-1.00), P=0.06. Moreover, in a large meta-analysis of three genome......Mitochondria play an important role in many processes, like glucose metabolism, fatty acid oxidation and ATP synthesis. In this study, we aimed to identify association of common polymorphisms in nuclear-encoded genes involved in mitochondrial protein synthesis and biogenesis with type II diabetes...

  18. Type 2 diabetes mellitus in children and adolescents: clinicoepidemiological, pathogenic and therapeutic aspects

    OpenAIRE

    Licea Puig, Manuel Emiliano; Bustamante Teijido, Mirelkis; Lemane Pérez, Maritza

    2008-01-01

    OBJETIVO: debido al incremento sostenido en la incidencia de la diabetes mellitus tipo 2 en personas < 20 años, nos proponemos revisar aspectos clínico-epidemiológicos, patogénicos y terapéuticos de la diabetes mellitus tipo 2 en niños y adolescentes. DESARROLLO: en la infancia, se estima que la diabetes mellitus tipo 2 representa del 2-3 % de todos los casos. Sin embargo, en los últimos años ha mostrado un incremento de 10 veces. Su prevalencia es mayor en afroamericanos, hispanos y nativos ...

  19. Osteogenesis Imperfecta with Celiac Disease and Type II Diabetes Mellitus Associated: Improvement with a Gluten-Free Diet

    Directory of Open Access Journals (Sweden)

    Luis Rodrigo

    2012-01-01

    Full Text Available Osteogenesis imperfecta (OI is a genetic disease, with a connective tissue alteration, consisting in the presence of multiple spontaneous fractures or after minimal traumatism. Its association with other metabolic processes is rarely described. We present the clinical case of a female adult patient of 43 years. From her infancy, she has had multiple fractures, needing several surgical interventions, and she was diagnosed of OI type 2 at adolescence age. Due mainly to difficulties in walking remaining in wheel-chair in the last three years, she was overweight with morbid obesity (BMI=45.4 and had a type-II DM associated. She suffered from recurrent abdominal pain and chronic diarrhea and was diagnosed of celiac disease (CD with increased intraepithelial duodenal infiltration, being classified as lymphocytic enteritis, Marsh I type. She was put on a gluten-free diet (GFD, having lost 6 kg of weight after 6 months, with a good control of DM-II and presenting a significant clinical improvement. It is rewarding to search the presence of two coincidental metabolic diseases associated to OI, specially CD, because of the dramatic clinical benefit in the general found after putting on a GFD.

  20. Osteogenesis Imperfecta with Celiac Disease and Type II Diabetes Mellitus Associated: Improvement with a Gluten-Free Diet

    Science.gov (United States)

    Rodrigo, Luis; Pérez-Martinez, Isabel

    2012-01-01

    Osteogenesis imperfecta (OI) is a genetic disease, with a connective tissue alteration, consisting in the presence of multiple spontaneous fractures or after minimal traumatism. Its association with other metabolic processes is rarely described. We present the clinical case of a female adult patient of 43 years. From her infancy, she has had multiple fractures, needing several surgical interventions, and she was diagnosed of OI type 2 at adolescence age. Due mainly to difficulties in walking remaining in wheel-chair in the last three years, she was overweight with morbid obesity (BMI = 45.4) and had a type-II DM associated. She suffered from recurrent abdominal pain and chronic diarrhea and was diagnosed of celiac disease (CD) with increased intraepithelial duodenal infiltration, being classified as lymphocytic enteritis, Marsh I type. She was put on a gluten-free diet (GFD), having lost 6 kg of weight after 6 months, with a good control of DM-II and presenting a significant clinical improvement. It is rewarding to search the presence of two coincidental metabolic diseases associated to OI, specially CD, because of the dramatic clinical benefit in the general found after putting on a GFD. PMID:22481956

  1. Ceramide content is higher in type I compared to type II fibers in obesity and type 2 diabetes mellitus

    DEFF Research Database (Denmark)

    Kristensen, Ditte Bech; Prats Gavalda, Clara; Larsen, Steen

    2012-01-01

    This study investigated fiber-type-specific muscle ceramide content in obese subjects and type 2 diabetes patients. Two substudies, one which compared type 2 diabetes patients to both lean- and obese BMI-matched subjects and the other study which compared lean body-matched post-obese, obese......, and control subjects, were performed. A fasting blood sample was obtained and plasma insulin and glucose determined. A muscle biopsy was obtained from deltoideus and vastus lateralis, and fiber-type ceramide content was determined by fluorescence immunohistochemistry. Insulin sensitivity estimated by Quicki...... index was higher in lean compared to type 2 diabetes patients and obese controls. Also in control and post-obese subjects, a higher insulin sensitivity was observed compared to obese subjects. Ceramide content was consistently higher in type I than in type II muscle fibers and higher in deltoideus than...

  2. Aspectos técnicos da interposição ileal com gastrectomia vertical como possível opção ao tratamento do diabetes mellitus tipo 2 Technical aspects of ileal interposition with sleeve gastrectomy as a possible option for the treatment of type 2

    Directory of Open Access Journals (Sweden)

    Aureo Ludovico de Paula

    2010-06-01

    Full Text Available INTRODUÇÃO: Há evidências que os melhores resultados em termos de resolução do diabetes mellitus tipo 2 (DM2 em pacientes obesos mórbidos são atingidos com as derivações biliopancreáticas, em especial o duodenal switch. Essas operações caracterizam-se por redução do estômago através de gastrectomia e o rápido trânsito dos alimentos para o íleo distal, através de expressiva derivação de segmentos do intestino delgado. A idéia da realização da técnica aqui apresentada baseou-se nestes princípios. MÉTODO: Os procedimentos são habitualmente realizados por via laparoscópica após pneumoperitônio com 12 a 15 mmHg e seis trocárteres. O paciente é inicialmente posicionado em proclive de 30º com o cirurgião à direita. Inicia-se a gastrectomia vertical tendo como referência anatômica a trifurcação distal do vago anterior. A desvascularização da grande curvatura é realizada e se estende até o ângulo esofagogástrico. Com um calibrador intra-gástrico de 20 mm posicionado ao longo da pequena curvatura gástrica inicia-se a ressecção gástrica no antro com grampeador linear e adicionalmente é feita uma sutura contínua. Para a realização da interposição ileal na altura do jejuno proximal o ângulo duodenojejunal é identificado e o jejuno seccionado 20 a 30 cm à jusante com grampeador linear. O ceco é identificado e o íleo distal seccionado a 30 cm no sentido proximal. Um segmento de 150 a 170 cm de íleo é medido em sentido proximal e seccionado com grampeador linear. O segmento de íleo é interposto de forma isoperistáltica no jejuno proximal previamente seccionado. Em seguida, são realizadas três enteroanastomoses: a primeira íleo-ileal próxima ao ceco; outra próxima ao ângulo duodenojejunal; a terceira íleo-jejunal. O procedimento pode também ser feito com interposição ileal na primeira porção do duodeno. CONCLUSÃO: Esta técnica demonstrou-se segura, com baixa morbidade e

  3. Classe II divisão 1 associada à deficiência transversal maxilar. Tratamento com disjuntor tipo Hyrax e aparelho de Herbst: relato de caso clínico Class II division 1 associated with maxillary transverse deficiency treated by Hyrax expander and Herbst appliance: clinical case report

    Directory of Open Access Journals (Sweden)

    Camila Leite Quaglio

    2009-10-01

    Full Text Available A má oclusão de Classe II divisão 1 de Angle é, frequentemente, acompanhada da atresia maxilar. Esse problema transversal da maxila deve ser corrigido, sempre que possível, antes da correção anteroposterior, sendo que os aparelhos de expansão rápida são os mais utilizados para isso. Para a correção da Classe II, atualmente, os aparelhos funcionais fixos são os mais estudados e empregados, por serem aparelhos intrabucais e necessitarem de menor colaboração do paciente. O objetivo deste estudo é demonstrar a estabilidade dos resultados obtidos após seis anos de tratamento com expansor tipo Hyrax, seguido do aparelho funcional fixo de Herbst e aparelho fixo. Após uma revisão da literatura, será apresentado um caso clínico, com atresia maxilar e má oclusão de Classe II divisão 1, tratado com essa terapia. O tratamento foi realizado em um curto período de tempo, com resultados funcionais e estéticos satisfatórios e mantidos ao longo dos anos.The Angle Class II division 1 malocclusion is often accompanied by maxillary transverse deficiency. When ever is possible, this maxillary transverse problem must be corrected before the anteroposterior correction. The rapid maxillary expanders is the appliance more used to correct the transverse deficiency. For the Class II malocclusion correction the fixed functional appliances are more studied and used. They are a kind of intraoral appliance that almost don't need patient's collaboration. The aim of this study is to show the results' stability after six years of the orthodontic treatment with Hyrax expander, followed by Herbst and straight wire appliances. After a literature review, a clinical case with maxillary transverse deficiency and Class II division 1 malocclusion treated with this therapy is reported. The treatment duration was very brief and the results were functionally and esthetically satisfactory with a long-term stability.

  4. Assessment of risk factors for development of Type-II diabetes mellitus among working women in Berhampur, Orissa

    Directory of Open Access Journals (Sweden)

    Malini D

    2009-01-01

    Full Text Available Objectives: 1 Assess general health condition and anthropological parameters of the working women. 2 Identify prevalence of Type-II Diabetes among them. 3 Assess risk factors associated with development of diabetes. 4 Educate them about Life Style Modifications. Materials and Methods: A cross sectional study was carried out in six educational institutes. A total of 100 working women were selected as study population. During the two-month study period, Fasting Blood Sugar (FBS was estimated to identify the diabetics and the Impaired Glucose Tolerance (IGT. Information from the study population was collected through pre-tested questionnaire using several anthropometric measurements. Results: Out of 100 women, 24 were having FBS compatible with IGT or diabetes. The incidence was highest in 46 to 55 yr age group. 75% of women with diabetes or IGT were in higher income group. Body Mass Index was more than 25 kg/m 2 in maximum (75% women having diabetes or IGT. 92% women with diabetes or IGT had their Waist Hip Ratio ≥0.85. Moreover, orientation towards healthy life style modification to control diabetes and its prevention was poor among the study population. Conclusion: Prevalence of diabetes and IGT was higher among urban working women and is increasing with increase in age. Obesity plays a major role in development of Type 2 diabetes. Several long- and short-term steps should be taken for promotion of healthy life style modifications to prevent diabetes and emergence of its complications.

  5. Diabetes tipo 2 y obesidad leve: tratamiento quirúrgico

    OpenAIRE

    Lanzaren S,Enrique

    2013-01-01

    Introducción: En la actualidad la diabetes mellitus tipo 2 (DM2) y la obesidad representan un serio problema de salud, comportándose como enfermedades epidémicas. Existe un gran interés en explorar distintas opciones de tratamiento de la DM2 en pacientes que no tienen obesidad mórbida. Objetivo: Reportar los parámetros de control glicémico en pacientes con DM2 y obesidad leve sometidos a bypass gástrico (BPG) a 3 años de seguimiento. Metodología: Estudio clínico prospectivo que incluye pacien...

  6. Guideline treatment results in regression of atherosclerosis in type 2 diabetes mellitus

    NARCIS (Netherlands)

    Strang, Aart C.; van Wijk, Diederik F.; Mutsaerts, Henri J. M. M.; Stroes, Erik S. G.; Nederveen, Aart J.; Rotmans, Joris I.; Rabelink, Ton J.; Box, Frieke M. A.

    2015-01-01

    Efficacy of guideline cardiovascular disease prevention regimens may differ between patients with or without type II diabetes mellitus. We therefore compared change in carotid artery wall dimensions in type II diabetes mellitus and non-type II diabetes mellitus patients with a history of a major

  7. Crescimento de genótipos de frangos tipo caipira

    Directory of Open Access Journals (Sweden)

    R. C. Veloso

    2015-10-01

    Full Text Available RESUMOObjetivou-se com este trabalho comparar o padrão de crescimento, mediante ajustes das respectivas curvas de crescimento por modelos não lineares, bem como estudar o desenvolvimento de cortes de carcaça em relação ao peso da carcaça em diferentes genótipos de frangos tipo caipira. Foram utilizados 840 pintos de um dia, machos, distribuídos em delineamento inteiramente ao acaso, dos seguintes genótipos da linhagem Redbro: Caboclo, Carijó, Colorpak, Gigante Negro, Pesadão Vermelho, Pescoço Pelado e Tricolor. As aves foram alojadas em 28 boxes, sendo 30 aves/boxe, em galpão de alvenaria com acesso a um piquete de 45m², com quatro repetições. O peso corporal individual dos frangos foi medido ao nascer, aos 14, 28, 42, 56, 70 e 84 dias de idade. Para a determinação das curvas de crescimento do peso corporal das aves, os dados coletados foram avaliados por meio dos modelos não lineares: Brody, Gompertz, Logístico, Richards e von Bertalanffy. Foi empregado o PROC NLIN do SAS, utilizando-se o método interativo de Gauss-Newton. Os critérios usados para escolha do modelo de melhor ajuste da curva de crescimento foram o coeficiente de determinação, o desvio padrão assintótico, o desvio médio absoluto dos resíduos e o índice assintótico. As análises para obtenção dos coeficientes alométricos foram realizadas por meio do PROC GLM do SAS para os genótipos Carijó, Colorpak, Pesadão Vermelho, Pescoço Pelado e Tricolor. Foram avaliados os pesos da carcaça, do peito, das coxas, das sobrecoxas, das pernas e das asas das aves abatidas aos 85 dias de idade. Apenas as equações propostas por Gompertz, von Bertalanffy e Logístico atingiram a convergência, e o modelo proposto por von Bertalanffy foi o mais adequado para descrever o crescimento dos genótipos de frangos caipiras. Todos os cortes avaliados apresentaram crescimento tardio em relação ao peso da carcaça em genótipos de frangos tipo caipira.

  8. Síndrome de Usher de tipo II: caracterización oftalmológica, auditiva y genética de una familia consanguínea Type II Usher syndrome: ophthalmological, auditory, and genetic characterization of a consanguineous family

    Directory of Open Access Journals (Sweden)

    Rásife Freyre Luque

    2011-09-01

    Full Text Available Se caracterizó a una familia consanguínea de 25 miembros, 3 de los cuales padecían el síndrome de Usher de tipo II, a través del estudio auditivo, oftalmológico y genético en el Centro de Retinosis Pigmentaria de Santiago de Cuba. Los pacientes (2 varones y 1 fémina tenían en común: aparición de la enfermedad en la etapa juvenil, mala visión nocturna, campos visuales reducidos, hipoacusia neurosensorial y resultados normales en las pruebas vestibulares; asimismo, en genética molecular, la electroforesis en gel de poliacrilamida reveló la presencia del marcador D1S237, estrechamente ligado al gen USH2 en el cromosoma 1. Esa caracterización permitirá aplicar la terapia génica y los implantes, tanto de células madre como cocleares, según corresponda.A consanguineous family of 25 members, 3 of whom suffered from type II Usher syndrome was characterized through the auditory, ophthalmologic, and genetic study in the Retinitis Pigmentosa Center from Santiago de Cuba. The patients (2 males and a female had in common: occurrence of the illness during youth, bad night vision, reduced visual fields, neurosensorial hypoakusia, and normal results in the vestibular tests; also, in molecular genetics, electrophoresis in polyacrilamide gel revealed the presence of the D1S237 marker, closely linked to the gene USH2 in chromosome 1. That characterization will allow to apply the genic therapy and both implants, mother cells and cochlear, as it corresponds.

  9. SENAM AEROBIC EXERCISER CHI MACHINE LEBIH EFEKTIF DARIPADA BERSEPEDA STATIS MENURUNKAN KADAR GULA DARAH PADA PASIEN DIABETES MELLITUS TIPE II DI PUSKESMAS MENGWI III

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    I Wayan Surasta

    2013-11-01

    Full Text Available Diabetes mellitus is a metabolic syndrome with hyperglycemic in characteristic. Exercise is one of intervention hopefully curing diabetes mellitus. The objective of the study was to analyze effect of aerobic exerciser chi- machine  and static bicycle   reducing of blood glucose level type 2 diabetes mellitus. Design   of study quasi eksperiment, pre test and post test control group design. Group 1 (10 samples was provided   aerobic exercise chi-machine and group 2 (10 samples static bicycle   15 minutes three time a week the duration of six weeks. Study  locati was at Mengwi III  Public Health Center, of Badung Regency with 20 samples was selected by using simple random sampling from the patient of diabetes mellitus type 2. Result of study is showed  aerobic exerciser chi-machine reduced the mean of blood glucose level of 124 mg%. Static bicycle  reduced mean of blood glucose level of 70.4 mg%. Conclusion of study aerobic exercise chi-machine more effective 17% than static bicycle exercise (p: 0,028 for reducing of blood glucose level type 2 diabetes mellitus.  

  10. Avaliação da silagem de sete genótipos de sorgo [(Sorghum bicolor (L Moench]. II. Padrão de fermentação

    Directory of Open Access Journals (Sweden)

    Brito A.F.

    2000-01-01

    Full Text Available Foram utilizados quatro genótipos de sorgo de porte alto, colmo suculento e com açúcar e três de porte baixo, colmo seco e sem açúcar com o objetivo de determinar as percentagens de matéria seca (MS, proteína bruta (PB, nitrogênio amoniacal em relação ao nitrogênio total (N-NH3/NT, pH e carboidratos solúveis em álcool (CHOS. O sorgo CMSXS156, de porte baixo, apresentou, o maior teor de MS (33,6% aos 28 dias de ensilagem. Os genótipos de porte baixo tiveram em média 8,8% de PB e os de porte alto 5%, diferença provavelmente devida à maior proporção de folhas e panícula nos de porte baixo. O pH médio das silagens aos 56 dias de fermentação foi de 3,6 e variou de 3,5 a 3,8, e o teor médio de N-NH3/NT nesse mesmo período foi de 5,3%, mostrando que as silagens apresentaram um adequado processo fermentativo. O teor médio de CHOS no material original foi de 9,7% e a variação de 13,2 a 16,5% e de 2,2 a 4,0% nos genótipos de porte alto e baixo, respectivamente.

  11. Diabetes mellitus

    NARCIS (Netherlands)

    Ahdi, M.; Gerdes, V. E.; Hoekstra, J. B.; Meesters, E. W.

    2012-01-01

    Currently there are over 740,000 patients with diabetes mellitus in the Netherlands, and this number will increase further in the coming years. Approximately 90% of patients has type 2 diabetes, a metabolic disorder that is often associated with obesity, hypertension and increased cholesterol

  12. Avaliação dos Tipos 1 e 2 de alcoolismo de Cloninger em homens participantes de um programa de tratamento ambulatorial Evaluation of Cloninger's Type I and Type II alcoholism in male alcoholics in an outpatient treatment program

    Directory of Open Access Journals (Sweden)

    Mário Sérgio Ribeiro

    2008-01-01

    Full Text Available CONTEXTO: A classificação Tipo 1/Tipo 2 de Cloninger é uma das mais estudadas tipologias de alcoolismo. OBJETIVOS: Testar a aplicabilidade dessa tipologia, caracterizar os subtipos identificados e avaliar seu comportamento ante um programa terapêutico. MÉTODOS: Partindo das variáveis descritas por Cloninger et al., 16 características de 308 homens alcoolistas tratados ambulatorialmente foram submetidas à análise de cluster para identificação de dois subgrupos (clusters. Posteriormente, efetivaram-se cruzamentos de dados para testar possível associação dos clusters identificados com variáveis demográficas e clínicas. RESULTADOS: Pacientes do cluster 1 foram caracterizados por início mais tardio dos problemas relacionados ao álcool, menos problemas sociais e maior sentimento de culpa em relação a seu consumo. O cluster 2 incluiu pacientes com história familiar de alcoolismo mais evidente, características anti-sociais mais presentes, mais uso disfuncional de outras substâncias psicoativas e piores níveis de adesão ao tratamento. CONCLUSÕES: Os resultados evidenciaram a diferenciada associação dos clusters a variáveis de tratamento e prognóstico; em sua maior parte foram coerentes com a classificação Tipo 1/Tipo 2 e reforçam a tese de que o simples diagnóstico de dependência ao álcool não é suficiente para atender às necessidades terapêuticas de subgrupos específicos de pacientes.BACKGROUND: Cloninger's Type 1/Type 2 classification is one of the most frequently studied alcoholism typologies. OBJECTIVES: To test the applicability of this typology, to characterize the identified subtypes and to evaluate their behavior in a therapeutic program. METHODS: Starting from variables described by Cloninger et al., 16 characteristics of 308 alcoholic men attending an outpatient treatment program were submitted to Cluster analysis for identification of two subgroups (clusters. Cross-tabulations were then performed to

  13. Diabetes mellitus

    International Nuclear Information System (INIS)

    Ogawa, Junichiro; Ito, Chikako

    1992-01-01

    It is believed that the pancreas is low sensitive to radiation. In this chapter, the effect of radiation on the pancreas is discussed in the light of the radiosensitivity of the pancreas in animal experiments and the occurrence of diabetes mellitus in A-bomb survivors. In an experiment on the whole-body irradiation with 800 rad using rats, a decrease in insulin secretion itself has not been noted, although a decrease in blood insulin and an increase in glucagon were associated with transiently increased blood glucose. In other studies, there was neither histologically nor endocrinologically abnormal findings due to several hundreds rad of radiation in the acute stage. For A-bomb survivors, blood levels of insulin tended to be slightly increased in the 40-59 age group of A-bomb survivors exposed at ≤1.5 km than those exposed at ≥3.0 km; and in the other age groups, there was no tendency for decreased blood levels of insulin. The ABCC-RERF Adult Health Study data (1958-1960) has revealed that there is no statistically significant correlation between the prevalence of diabetes mellitus and A-bomb radiation; nor has this been noted in any other study. Neither the prevalence of diabetes mellitus nor its complications is found to be independent upon distance from the hypocenter. (N.K.)

  14. Diabetes mellitus

    OpenAIRE

    Skiadopoulos, Dionysios

    2013-01-01

    This theses on Diabetes Mellitus aims at giving an insight at various aspects of this chronic disease and the risk factors that lead to it; the varius ways it develops in the human body; the old and new approaches to treatment, both from a pharmacological and a non- pharmacologiacal point of view; ways to prevent and to manage the diabetes complications; how to improve the live of the diabetic patients who are faced with not only physical but also psychological problems; statistical data from...

  15. Seroprevalencia del virus linfotrópico humano de tipos I y II en donantes del Banco de Sangre de la Fundación Valle del Lili, Cali, Colombia, 2008-2014

    Directory of Open Access Journals (Sweden)

    Carmenza Macía

    2016-08-01

    Conclusión. Se encontró una alta prevalencia de pruebas reactivas para el HTLV I-II en comparación con otros estudios. Los resultados de este estudio son un punto de partida para el desarrollo de estudios poblacionales.

  16. Analytical Evaluation to Determine Selected PAHs by HPLC in a Type 2 Fuel; Evaluacion Analitica de 4 Metodos de Determinacion de PAHs medianteHPLC en un Fuel de Tipo II

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Alonso, S.; Perez Pastor, R. M.; Sevillano Castano, M. L.; Escolano Segovia, O.; Garcia Frutos, F. J.

    2009-05-21

    An evaluation of analytical parameters to determine selected PAHs in a fuel oil type II by HPLC coupled to fluorescence and diode detectors is presented. The study was focused on four conventional treatments of these kinds of oil samples and the main objective was giving a measure of confidence level of PAH results in the fuel oil. This study was performed in the frame of the project Assessment of natural attenuation of PAHs in agricultural soil contaminated with fuel from an accidental spill (Spanish National Plain I+D+I, CTM2007-64537). This paper is presented as follows: Analysis of reference material 1582 (NIST) by using the four kinds of sample treatments of interest. Application of variance analysis to compare results obtained from type II fuel by using each sample treatment and chromatographic detector. Finally, a statistic calculation was performed to measure uncertainty components in chromatographic analysis. (Author)

  17. Effect of non-surgical periodontal therapy on insulin resistance in patients with type II diabetes mellitus and chronic periodontitis, as assessed by C-peptide and the Homeostasis Assessment Index.

    Science.gov (United States)

    Mammen, Jerry; Vadakkekuttical, Rosamma Joseph; George, Joseraj Manaloor; Kaziyarakath, Jaishid Ahadal; Radhakrishnan, Chandni

    2017-08-01

    A bidirectional relationship exists between diabetes and periodontitis. In the present clinical trial, we evaluated the effects of non-surgical periodontal therapy (NSPT) on insulin resistance in patients with type II diabetes mellitus (DM) and chronic periodontitis. Forty chronic periodontitis patients with type II DM were selected and equally allocated to case and control groups. All patients were assessed for periodontal parameters and systemic parameters. The case group received NSPT, and both groups were re-evaluated after 3 months. All periodontal parameters were found to be significantly improved in the case group compared to the control group 3 months after NSPT. The mean differences in systemic parameters, such as fasting serum C-peptide, Homeostasis Assessment (HOMA) Index-insulin resistance, and HOMA-insulin sensitivity, from baseline to 3 months for the case group were 0.544 ± 0.73, 0.54 ± 0.63, and -25.44 ± 36.81, respectively; for the control group, they were significant at -1.66 ± 1.89, -1.48 ± 1.86, and 31.42 ± 38.82 respectively (P periodontal inflammation could affect glycemic control and insulin resistance. Effective periodontal therapy reduced insulin resistance and improved periodontal health status and insulin sensitivity in patients with type II DM and chronic periodontitis. © 2016 John Wiley & Sons Australia, Ltd.

  18. Exercício de força ativa a via AKT/mTor pelo receptor de angiotensina II tipo I no músculo cardíaco de ratos Activation of AKT-mTor signaling pathways by angiotensin II receptor type 1 after a session of strength exercise in cardiac muscle of rats

    Directory of Open Access Journals (Sweden)

    Stéphano Freitas Soares Melo

    2011-09-01

    Full Text Available O receptor de angiotensina II tipo I (AT1 tem uma importante participação no desenvolvimento da hipertrofia cardíaca. Em um trabalho publicado anteriormente, por nosso grupo, demonstramos que o bloqueio do receptor AT1 durante o treinamento de força inibiu a hipertrofia cardíaca em ratos. Por isso, o objetivo deste trabalho foi estudar a participação do receptor AT1 na ativação de vias de sinalização intracelular relacionadas com o aumento da síntese de proteína em ratos submetidos a uma sessão de exercício de força. Para isso, realizamos um experimento com seis grupos de animais (n = 6; cada: controle (Con, exercitado e sacrificado cinco minutos após o exercício (Exe 5, exercitado e sacrificado 30 minutos após o exercício (Exe 30, controle tratado com losartan (Con Los, tratado com losartan, exercitado e sacrificado cinco minutos após o exercício (Exe 5 Los, tratado com losartan, exercitado e sacrificado 30 minutos após o exercício (Exe 30 Los. Os resultados mostram que no grupo Exe 5 e Exe 30 ocorreu um aumento de 63% (P The angiotensin II type I (AT1 receptor has an important participation in the development of cardiac hypertrophy. Previously, we have shown that AT1 receptor participates in the cardiac hypertrophy induced by resistance training in rats. Here, we studied the involvement of AT1 receptor in the activation of intracellular signaling pathways related to the concentric HC in rats submitted to a session of strength exercise. Male Wistar rats were divided into 6 groups (n= 6 each: control (Con; exercised and killed 5 minutes after exercise (Exe 5; exercised and killed 30 minutes after exercise (Exe 30; control treated with Losartan (Con Los; treated with Losartan, exercised and killed 5 minutes after the exercise (Exe Los 5; treated with Losartan, exercised and killed 30 minutes after training (Exe Los 30. The results show that phosphorylation activity of AKT in group Exe 5 and Exe 30 increased 63% (P < 0

  19. Human T-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Pará, Brazil Infecção pelos vírus linfotrópicos humanos de células T tipos I e II entre pacientes com doença neurológica em Belém, Pará, Brasil

    Directory of Open Access Journals (Sweden)

    Olinda Macêdo

    2004-02-01

    Full Text Available Serum- and/or- cerebrospinal fluid (CSF samples obtained from 190 patients suffering from chronic, progressive neurological disease were screened for the presence of human T-cell lymphotropic viruses type I (HTLV-I and type II (HTLV-II antibodies over a six-year period (1996 to 2001 in Belém, Pará, Brazil. Patients were of both sexes (male subjects, 52% with ages ranging from 2 to 79 years (mean, 35.9. Overall, 15 (7.9% subjects - of whom 12 (80% were female adults - reacted HTLV-I/II-seropositive when screened by enzyme-linked immunosorbent assay (ELISA. Serum samples from 14 of these patients were also analyzed using a recombinant Western blot (WB assay that yielded HTLV-I-, HTLV-II-, and HTLV-I/II- reactivities for 10 (71.4%, 3 (21.4% and 1 (7.2% of them, respectively. The yearly rates of HTLV-I/II antibodies ranged from 2.6% (2001 to 21.7% (2000, with progressively increasing seropositivities from 1998 to 2000. Altogether, walking difficulty (n = 5 subjects, spasticity (n = 4 and leg weakness (n = 3 accounted for 80% of symptoms recorded among the 15 patients whose sera had antibodies to HTLV-I/II as detected by ELISA. These findings provide evidence that both HTLV-I and HTLV-II play a role in the development of chronic myelopathy in Belém, Pará, Northern Brazil.Amostras de soro e/ou líquido céfalo-raquidiano (LCR foram obtidas de 190 pacientes com quadro de doença neurológica crônica e progressiva, com vistas à detecção de anticorpos para os vírus linfotrópicos humanos de células T dos tipos I (HTLV-I e II (HTLV-II, durante um período de seis anos (1996 a 2001 em Belém, Pará, Brasil. O grupo compreendia ambos os sexos (homens, 52%, com idades variando de 2 a 79 anos (média, 35,9 anos. Tomando-se os resultados como um todo, 15 (7,9% indivíduos, incluindo 12 (80% mulheres adultas, apresentaram anticorpos para HTLV-I/II a partir da triagem pelo procedimento imunoenzimático (ELISA. Soros de 14 desses pacientes também foram

  20. Tratamiento de una maloclusión clase II división 1 utilizando un aparato expansor y exodoncias de 4 primeras premolares / Tratamiento de una maloclusión clase II división 2 tipo B utilizando un aparato distalizador / Tratamiento de camuflaje de una maloclusión clase III con exodoncia de un incisivo central inferior / Tratamiento de una maloclusión clase I por biprotrusión y DAD con exodoncias de 4 primeras premolares / Tratamiento de una maloclusión clase I por DAD con extracciones asimétricas

    OpenAIRE

    González Torres, Carlos Rodrigo

    2015-01-01

    Describe el tratamiento de cinco casos clínicos de ortodoncia, atendidos en la Clínica Especializada de la Facultad de Odontología de la Universidad de San Martín de Porres durante el periodo Agosto 2009 - Marzo 2012, tratándose de: 1. Tratamiento de una maloclusión clase II división 1 utilizando un aparato expansor y exodoncias de 4 primeras premolares. 2. Tratamiento de una maloclusión clase II división 2 tipo B utilizando un aparato distalizador. 3. Tratamiento de camuflaje de una...

  1. Evaluacion de factores de riesgo exógenos y endógenos para la retinopatía diabética en pacientes con diabetes mellitus tipo 2 de larga evolución en un seguimiento a 18 meses

    OpenAIRE

    Roig Revert, María José

    2015-01-01

    La diabetes mellitus se ha convertido en la enfermedad metabólica más frecuente hasta el punto de considerarse como la epidemia del siglo XXI. La retinopatía diabética (RD) es la complicación microvascular más frecuente de dicha enfermedad siendo la causa principal de pérdida de visión y ceguera legal en adultos en edad laboral, entre 20 y 65 años, en los países industrialmente desarrollados. OBJETIVO PRINCIPAL: Determinar las posibilidades de predecir el riesgo de presentación o progresi...

  2. Global burden of disease attributable to diabetes mellitus in Brazil Carga global de doença devida e atribuível ao diabetes mellitus no Brasil

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    Andreia Ferreira de Oliveira

    2009-06-01

    Full Text Available Type II diabetes mellitus accounts for 90% of all cases of diabetes, and its inclusion in health evaluation has shown that its complications have a considerable impact on the population's quality of life. The current article presents the results of the Global Burden of Disease Study in Brazil for the year 1998, with an emphasis on diabetes mellitus and its complications. The indicator used was disability-adjusted life years (DALY, using a discount rate of 3%. In Brazil, ischemic heart disease, stroke, and diabetes accounted for 14.7% of total lost DALYs. Brazil showed a higher proportion of years lived with disability (YLDs among total DALYs for diabetes as compared to other countries. Retinopathy and neuropathy were the complications that contributed most to YLDs. According to forecasts, diabetes mellitus will have an increasing impact on years of life lost due to premature death and disability in the world, shifting from the 11th to 7th cause of death by 2030. It is thus urgent to implement effective measures for prevention, early diagnosis, counseling, and adequate follow-up of patients with diabetes mellitus.O diabetes mellitus tipo II é responsável por 90% de todos os casos de diabetes, e sua inclusão na avaliação de saúde evidencia que as suas complicações têm um considerável impacto na qualidade de vida de uma população. O presente artigo apresenta os resultados do Estudo de Carga Global de Doença, realizado no Brasil para o ano de 1998, com ênfase no diabetes mellitus e suas complicações. O indicador utilizado foi o disability-adjusted life years (DALY, ao qual aplicou-se a taxa de desconto de 3%. No Brasil, doenças isquêmicas do coração, doenças cardiovasculares e diabetes contribuíram com 14,7% do total de DALY. Observou-se uma maior participação do years lived with disability (YLD no total de DALY para o diabetes quando comparado a outros países. As complicações retinopatias e neuropatias foram as que mais

  3. Diabetes tipo 2 en niños: Serie de casos

    Directory of Open Access Journals (Sweden)

    Helard Manrique-Hurtado

    2015-01-01

    Full Text Available Objetivos: Describir las características clínicas y bioquímicas de un grupo de niños y adolescentes con diagnóstico reciente de diabetes tipo 2. Material y métodos: Estudio descriptivo, retrospectivo, tipo de serie de casos. Se definió caso al niño o adolescente con glucosa plasmática en ayunas mayor a 126 mg/dl, ausencia de antiGAD y péptido C mayor a 1,5 ng/dl. Se excluyeron a los pacientes con diagnóstico previo de diabetes mellitus tipo 1, diabetes tipo MODY o diabetes secundaria a uso de fármacos. Resultados: La edad media fue 14,3 años, 59% fueron mujeres y 43% tenía por lo menos un padre con diabetes tipo 2. Al momento del diagnóstico, el índice de masa corporal fue 32,8 kg/m2, 85% tenía acantosis nigricans y 68% estaba en estadio Tanner IV y V. El tratamiento inicial incluyó el uso de hipoglicemiantes orales en 75% de los casos, siendo más frecuente el uso de metformina (64,3%. Solamente el 41% de los pacientes recibía algún tipo de insulina. Conclusiones: Los niños y adolescentes con diabetes tipo 2, tienen una frecuencia aumentada de obesidad/sobrepeso, acantosis nigricans y antecedente familiar de DM2. En general, tienen mal control metabólico y reciben metformina como tratamiento inicial.

  4. Estudo da reabsorção radicular apical após o uso de aparelho extrabucal no tratamento da má oclusão do tipo Classe II, 1ª divisão dentária Study of apical root resorption after occipital headgear wear on the treatment of dental Class II, division 1 malocclusion

    Directory of Open Access Journals (Sweden)

    Vânia Célia Vieira de Siqueira

    2009-04-01

    Full Text Available OBJETIVO: o presente estudo verificou o efeito do uso do aparelho extrabucal (AEB sobre a intensidade da reabsorção radicular apical nos primeiros molares permanentes superiores submetidos à ação do aparelho. MÉTODOS: foram avaliadas as radiografias periapicais da região dos primeiros molares permanentes superiores, bilateralmente, de 19 jovens leucodermas, do gênero feminino, com idades entre 8 e 10 anos, com má oclusão do tipo Classe II, 1ª divisão dentária, pré e pós-tratamento com AEB de tração alta. As 76 radiografias foram divididas em dois grupos, de acordo com o grau de formação radicular. O grupo A consistiu de 18 radiografias com formação radicular incompleta, com exceção da raiz palatina, ao início do tratamento e 18 ao final. O grupo B consistiu de 20 radiografias com formação radicular completa ao início do tratamento e 20 ao final. Mensurou-se os comprimentos radiculares utilizando um paquímetro digital e submeteu-se as medidas obtidas ao teste de erro do método e à análise estatística (teste t de Student para verificar as diferenças no comprimento radicular antes e após o tratamento com o AEB. RESULTADOS: no grupo A ocorreu um aumento significativo dos comprimentos radiculares, enquanto no grupo B as diferenças dos comprimentos radiculares não foram significativas. As medidas pós-tratamento no grupo A não diferiram das medidas pré-tratamento no grupo B, ou seja, os dentes com formação radicular incompleta ao início do tratamento apresentaram crescimento radicular normal durante o tratamento ativo. CONCLUSÃO: concluiu-se que o uso do AEB não influenciou negativamente na formação radicular e não provocou reabsorção apical nos molares submetidos à ação do aparelho, sugerindo que o AEB não apresentou riscos à estrutura e formação radicular quando corretamente indicado e aplicado.AIM: The aim of this study was to verify the effect of occipital headgear wear on the intensity of

  5. An evaluation of US patent 2015065565 (A1) for a new class of SGLT2 inhibitors for treatment 1 of type II diabetes mellitus.

    Science.gov (United States)

    Jiang, Meiyan; Steyger, Peter S

    2015-01-01

    Type 2 diabetes mellitus (T2DM) is a growing and serious global health problem. Pharmacological inhibition of the sodium-glucose cotransporter-2 (SGLT2; SLC5A2) increases urinary glucose excretion, decreasing plasma glucose levels in an insulin-independent manner. Agents that inhibit SGLT2 have recently become available for clinical therapy of T2DM. The patent claims a new class of SGLT2 inhibitors: derivatives of dioxa-bicyclo[3.2.1]octane-2,3,4-triol (including ertugliflozin; PF-04971729). The invention describes the design, synthesis and pharmacological tests related to ertugliflozin, which could ultimately lead to efficacious therapy for T2DM alone or in combination with other anti-diabetic agents. Ertugliflozin is likely to be of great clinical significance in the near future. Continued analysis of ertugliflozin derivatives to now validate safe and efficacious treatment of T2DM in a larger number of clinical subjects over an extended period is needed to further support clinical utility. Identification, and discussion, of likely contra-indications is also needed.

  6. Nutrición en la Diabetes Mellitus 2

    OpenAIRE

    González González, Isabel

    2014-01-01

    La Diabetes Mellitus (DM), junto con la obesidad, es considerada como uno de los mayores problemas a nivel mundial. Se caracteriza por una alteración en la producción de insulina y una elevación en los niveles plasmáticos de glucosa. Dicha alteración, si es por déficit absoluto en la producción se conoce como DM tipo 1 o insulinodependiente. Si la alteración se refiere a un déficit relativo en la producción, hablamos de DM tipo 2. En otras ocasiones existe resistencia a la insulina. Los altos...

  7. Prevalência de complicações micro e macrovasculares e de seus fatores de risco em pacientes com diabetes melito do tipo 2 em atendimento ambulatorial Prevalence of micro and macroangiopatic chronic complications and their risk factors in the care of out patients with type 2 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Rafael Selbach Scheffel

    2004-09-01

    Full Text Available OBJETIVOS: O diabetes melito (DM do tipo 2 está associado ao desenvolvimento de complicações macroangiopáticas [cardiopatia isquêmica (CI, doença vascular periférica (DVP e acidente vascular cerebral (AVC] e microangiopáticas [retinopatia diabética (RD, nefropatia diabética (ND e neuropatia sensitiva distal (NSD]. Os objetivos deste estudo foram avaliar a prevalência das complicações crônicas em pacientes com DM do tipo 2 e aferir os seus possíveis fatores de risco. MÉTODOS: Estudo transversal, incluindo 927 pacientes com DM do tipo 2 atendidos ambulatorialmente em três centros médicos do Rio Grande do Sul: Hospital de Clínicas de Porto Alegre (n = 475, Grupo Hospitalar Conceição (n = 229 e Hospital São Vicente de Paula (n = 223. Dentre os pacientes, 42% eram homens, a média de idade era de 59 ± 10 anos e a mediana da duração do DM do tipo 2 era 11 (5 - 43 anos. A RD foi definida por fundoscopia direta; a CI através do questionário da OMS e/ou alterações eletrocardiográficas e/ou anormalidades perfusionais na cintilografia miocárdica; a NSD por sintomas compatíveis e ausência de sensação ao monofilamento de 10g e/ou ao diapasão; a DVP pela claudicação e ausência de pulsos pediosos; o AVC por seqüelas ou história compatível e a ND pela excreção urinária de albumina (>20 µg/min. A hipertensão arterial sistêmica (HAS foi definida pelos níveis pressóricos (>140/90 mmHg e/ou uso de drogas anti-hipertensivas. Foram calculados o índice de massa corporal (IMC, kg/m² e a razão cintura-quadril (RCQ. RESULTADOS: A CI estava presente em 36% e a DVP em 33% dos pacientes. Dentre as complicações microvasculares, 37% tinham doença renal (12% macroalbuminúricos e 48% RD (15% retinopatia proliferativa. A NSD foi encontrada em 36% dos pacientes. HAS estava presente em 73% dos pacientes. O colesterol estava acima de 200 mg/dl em 64%, enquanto o IMC > 30 kg/m² em 36%. Vinte e dois por cento dos pacientes

  8. Association of Barrett’s Esophagus With Type II Diabetes Mellitus: Results From a Large Population-based Case-Control Study

    Science.gov (United States)

    IYER, PRASAD G.; BORAH, BIJAN J.; HEIEN, HERBERT C.; DAS, ANANYA; COOPER, GREGORY S.; CHAK, AMITABH

    2013-01-01

    BACKGROUND & AIMS Central obesity could increase the risk for Barrett’s esophagus (BE) and esophageal adenocarcinoma by mechanical and/or metabolic mechanisms, such as hyperinsulinemia. We performed an epidemiologic study to determine whether prior type 2 diabetes mellitus (DM2) is associated with BE. METHODS We performed a population-based case-control study using the General Practice Research Database, a UK primary care database that contains information on more than 8 million subjects, to identify cases of BE (using previously validated codes; n = 14,245) and matched controls without BE (by age, sex, enrollment date, duration of follow-up evaluation, and practice region by incidence density sampling; n = 70,361). We assessed the association of a prior diagnosis of DM2 with BE using conditional univariate and multivariable regression analysis. Confounders assessed included smoking, obesity measured by body mass index (BMI), and gastroesophageal reflux disease. RESULTS BE cases were more likely than controls to have smoked (52.4% vs 49.9%), have a higher mean BMI (27.2 vs 26.9), and a higher prevalence of DM2 than controls (5.8% vs 5.3%). On multivariable analysis, DM2 was associated with a 49% increase in the risk of BE, independent of other known risk factors (odds ratio, 1.49; 95% confidence interval, 1.16–1.91). This association was stronger in women than men. Results remained stable with sensitivity analyses. CONCLUSIONS In a large population-based case-control study, DM2 was a risk factor for BE, independent of obesity (as measured by BMI) and other risk factors (smoking and gastroesophageal reflux disease). These data suggest that metabolic pathways related to DM2 should be explored in BE pathogenesis and esophageal carcinogenesis. PMID:23591277

  9. Correlation of urinary monocyte chemo-attractant protein-1 with other parameters of renal injury in type-II diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Ibrahim Salwa

    2008-01-01

    Full Text Available Diabetic nephropathy (DN is the leading cause of end-stage renal disease in the western world. Increased number of interstitial macrophages has been observed in biopsies from patients with DN. Monocyte chemo-attractant protein-1 (MCP-1 is the strongest known chemo-tactic factor for monocytes and is upregulated in DN. We examined urinary levels of MCP-1 in patients with type-2 diabetes mellitus (DM to assess its possible correlation with other para-meters of renal injury. The urinary MCP-1 level was assessed in 75 patients with type-2 DM (25 patients each with no microalbuminuria, with macroalbuminuria and, with renal impairment and compared them with matched healthy control subjects. The HbA1c and estimated glomerular fil-tration rate (eGFR derived from the abbreviated Modification of Diet in Renal Disease (MDRD equation were examined in the study groups in relation to the urinary MCP-1. The urinary MCP-1 level was significantly higher in patients with micro and macroalbuminuria (167.41 ± 50.23 and 630.87 ± 318.10 ng/gm creatinine respectively as compared with normoalbuminuric patients and healthy controls (63.85 ± 21.15 and 61.50 ± 24.81 ng/gm creatinine, p< 0.001. MCP-1 correlated positively with urine albumin/creatinine ratio (ACR (r= 0.75, p< 0.001, HbA1c (r= 0.55, p< 0.001 and inversely with eGFR (r=-0.60, p< 0.001. Our findings suggest that hyperglycemia is associated with increased urinary levels of MCP-1 that is closely linked to renal damage as reflected by proteinuria and eGFR levels. Collectively, these findings suggest that MCP-1 is in-volved in the pathogenesis of diabetic nephropathy through its various stages.

  10. Opções terapêuticas atuais para diabetes mellitus tipo 2 e doença arterial coronariana: prevenção secundária intensiva focada no treinamento físico versus revascularização percutânea ou cirúrgica Las opciones terapeuticas actuales en la diabetes mellitus 2 y la enfermedad coronaria: la prevención secundaria intensiva con el enfoque en el entrenamiento del ejercicio contra la revascularización quirurgica y percutanea Current therapeutical options in diabetes mellitus type 2 and coronary artery disease: intensive secondary prevention with focus on exercise training versus percutaneous or surgical revascularization

    Directory of Open Access Journals (Sweden)

    Sebastian Sixt

    2004-06-01

    Full Text Available O diabetes mellitus é um dos maiores fatores de risco para a doença arterial coronariana. A doença progride mais rápido em pacientes diabéticos e está associada com pior prognóstico. Embora a cirurgia de revascularização ou intervenção percutânea com a implantação de stent garanta rápido alívio dos sintomas em pacientes com doença arterial coronariana estabelecida, não existe substancial benefício prognóstico. Uma intervenção multifatorial incluindo medidas dietéticas, controle glicêmico, tratamento anti-hipertensivo e exercícios físicos regulares tem influência positiva nos fatores de risco modificáveis, na melhora de outras funções cardiovasculares e na tolerância ao exercício livre de angina.La diabetes mellitus es uno de los factores de riesgo mayores para la enfermedad de la arteria coronaria. La enfermedad progresa más rápidamente en los pacientes diabéticos y está asociada con uno de los más peores pronósticos. Aunque la cirugía de desviación o las intervenciones percutaneas con la implantación del stent proporcionan un alivio sintomático rápido para los pacientes con esta enfermedad de la arteria coronaria establecida, no tiene el beneficio de un pronóstico sustancial. Una intervención multi-factorial que incluye las medidas dietéticas, mando de sangre-glucosa, el tratamiento del antihipertensivo y ejercicio físico regular tiene una influencia positiva en los factores de riesgo modificables, y mejora entre otros la aptitud cardiovascular y la tolerancia del ejercicio libre de anginas.Diabetes mellitus is one of the major risk factors for coronary artery disease. The disease progresses faster in diabetic patients and is associated with a worse prognosis. Although bypass surgery or percutaneous interventions with stent implantation provide quick symptomatic relief for patients with stable coronary artery disease, it has no substantial prognostic benefit. A multifactorial intervention including

  11. Synthesis, α-glucosidase inhibitory activity and in silico study of tris-indole hybrid scaffold with oxadiazole ring: As potential leads for the management of type-II diabetes mellitus.

    Science.gov (United States)

    Taha, Muhammad; Rahim, Fazal; Imran, Syahrul; Ismail, Nor Hadiani; Ullah, Hayat; Selvaraj, Manikandan; Javid, Muhammad Tariq; Salar, Uzma; Ali, Muhammad; Khan, Khalid Mohammed

    2017-10-01

    Discovery of α-glucosidase inhibitors has been actively pursued with the aim to develop therapeutics for the treatment of type-II diabetes mellitus and the other carbohydrate mediated disease. In continuation of our drug discovery research on potential antidiabetic agents, we synthesized novel tris-indole-oxadiazole hybrid analogs (1-21), structurally characterized by various spectroscopic techniques such as 1 H NMR, EI-MS, and 13 C NMR. Elemental analysis was found in agreement with the calculated values. All compounds were evaluated for α-glucosidase inhibiting potential and showed potent inhibitory activity in the range of IC 50 =2.00±0.01-292.40±3.16μM as compared to standard acarbose (IC 50 =895.09±2.04µM). The pharmacokinetic predictions of tris-indole series using descriptor properties showed that almost all compounds in this series indicate the drug aptness. Detailed binding mode analyses with docking simulation was also carried out which showed that the inhibitors can be stabilized by the formation of hydrogen bonds with catalytic residues and the establishment of hydrophobic contacts at the opposite side of the active site. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Musculoskeletal manifestations in type 2 diabetes mellitus

    OpenAIRE

    Deepti P. Deshmukh; Asmita G. Akarte

    2017-01-01

    Background: Musculoskeletal complications of diabetes have been generally ignored and poorly treated as compared to other complications. Hence we carried out this study to find the prevalence of musculoskeletal manifestations in type II diabetes mellitus and its correlation with age, BMI, duration of diabetes, and control of diabetes. Methods: 100 consecutive patients of type II diabetes were studied. Duration of diabetes, control of diabetes, and any musculoskeletal complaints were noted....

  13. Management of cataract with macular oedema due to diabetes mellitus Type-II and hypertension with grid laser prior to surgery and intra-vitreal bevacizumab (avastin) peroperatively

    International Nuclear Information System (INIS)

    Wahab, S.; Ahmed, J.

    2010-01-01

    To study the visual outcome in patients subjected to cataract extraction with prior grid laser and intraoperative intravitreal bevacizumab injection. Methods: This prospective case series comprised of 38 patients subjected to phacoemulsification and in the bag intraocular lens implantation at Al-Noor Eye Hospital and Sindh Govt Lyari General Hospital Karachi from January 2007 to December 2008. All the patients had prior macular grid treatment and intra-operative injection of intra-vitreal Avastin. Diabetes mellitus duration, preoperative glycosylated haemoglobin (HbA1c) level and other systemic and local complications of diabetes were recorded. The patients were clinically assessed with bio microscopic examination preoperatively, and postoperatively on day 1, week 1, and in months 1, 2, 3 and 6 respectively. Visual acuity and state of macular oedema was clinically assessed and documented. Results: Out of thirty-eight patients, eighteen were males and 20 were females. Mean duration of diabetes was 9.92 +- 5.5 years (Range 4-16) while that of hypertension was 7.87 +- 3.66 years (Range = 2-15). HbA1c level was 8.36% +- 1.93% (range 6.3 - 12.3). Thirty-one (81.5%) patients had HbA1c level 8.0% or above indicating a poor control. At 6 months of follow up best corrected distant visual acuity of 6/6 to 6/9 was achieved in 23(60.5 %), 6/12 in 11(28.9%) and 6/24 in 4(10.5%) cases while best corrected near acuity of N/6 was achieved in 22(57.8%) N/8 in 12(31.4%) and N/12 in 4(10.5%) cases. At 6 months follow up visual acuity declined in two cases because of uncontrolled diabetes and hypertension. Conclusion: Cataract surgery in diabetic patients with macular oedema and hypertension has a good visual outcome if prior macular grid laser is performed and intra-vitreal anti VEGF is injected during surgery. (author)

  14. Mucormycosis and chromoblastomycosis occurring in a patient with leprosy type 2 reaction under prolonged corticosteroid and thalidomide therapy Mucormicose e cromoblastomicose em um paciente com reação hansênica tipo II sob terapia prolongada com corticosteróide e talidomida

    Directory of Open Access Journals (Sweden)

    Flávia Machado Alves Basílio

    2012-10-01

    Full Text Available Mucormycosis is an uncommon fungal infection caused by Mucorales. It frequently occurs in patients with neutropenia, diabetes, malignancy and on corticoid therapy. However, it is rare in patients with AIDS. Clinical disease can be manifested in several forms. The case reported illustrates the rare occurrence of chromoblastomycosis and mucormycosis in an immunosuppressed patient with multibacillary leprosy, under prolonged corticosteroid and thalidomide therapy to control leprosy type 2 reaction. Neutrophil dysfunction, thalidomide therapy and work activities are some of the risk factors in this case. Chromoblastomycosis was treated by surgical excision and mucormycosis with amphotericin B. Although the prognosis of mucormycosis is generally poor, in the reported case the patient recovered successfully. This case should alert dermatologists to possible opportunistic infections in immunosuppressed patients.Mucormicose é uma infecção fúngica incomum causada por Mucorales. Ocorre frequentemente em pacientes com neutropenia, diabetes, corticoterapia e condições malignas. Porém, é rara em pacientes com AIDS. A doença pode apresentar-se em diferentes formas. Este caso ilustra a rara ocorrência de mucormicose e cromoblastomicose em um paciente com hanseníase multibacilar, que estava sendo tratado com prednisona e talidomida devido a eritema nodoso (reação hansênica tipo II. Disfunção de neutrófilos, uso de talidomida e atividades profissionais são alguns fatores de risco neste caso. A cromoblastomicose foi tratada por excisão cirúrgica e a mucormicose com anfotericina B. Embora o prognóstico da mucormicose seja ruim, neste caso o tratamento foi bem sucedido. Este caso alerta dermatologistas para a possibilidade de infecções oportunistas em pacientes imunossuprimidos.

  15. Additive effects of cilnidipine, an L-/N-type calcium channel blocker, and an angiotensin II receptor blocker on reducing cardiorenal damage in Otsuka Long-Evans Tokushima Fatty rats with type 2 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Mori Y

    2014-06-01

    receptor type 1 antagonism. Thus, Cil may inhibit the progression of cardiorenal disease in type 2 diabetes patients by acting as an N-type CCB and inhibiting the aldosterone secretion and SNS activation when these drugs were administered in combination with an Ang II receptor blocker. Keywords: calcium channel blocker, combination therapy, angiotensin, type 2 diabetes mellitus

  16. Diabetes Mellitus and Osteoporosis

    Directory of Open Access Journals (Sweden)

    Dilek Durmuş

    2005-09-01

    Full Text Available Osteoporosis is a condition of bone fragility resulting from micro-architectural deterioration and decreased bone mass. Studies on the presence of a generalized osteoporosis related to diabetes mellitus (DM are few and controversial. Factors associated with osteoporosis diabetes in which may account for the patogenesis of diabetic bone loss have been studied. This article will review the relevant litarature relating to diabetes and osteoporosis including cellular and animal models. These studies include vascular and neuropathic mechanism, poor glisemic control, abnormalities of calcium and vitamin D metabolism and hypercalciuria with secondary increase in parathyroid hormone secretion, the role of insülin and insülin like growth factor I. It appears that there is a great deal of variability in the bone mineral density and fracture rates in both type I and type II DM. This may reflect multiple factors such as the population, age, duration of diabetes and insülin use. There is need for further longitudinal studies, including the incidence and risk factors for osteoporosis in DM.

  17. Seleção de genótipos de Brachiaria Ruziziensis quanto ao alumínio em solução nutritiva: II: Avaliação da tolerância ao alumínio Brachiaria Ruziziensis genotypes selection: II: Evaluation of the aluminum tolerance

    Directory of Open Access Journals (Sweden)

    Paulo Sérgio Balbino Miguel

    2011-01-01

    Full Text Available O alumínio, em solos ácidos, é um dos principais responsáveis pela baixa produtividade de culturas. O objetivo deste trabalho foi avaliar a variabilidade genética da Brachiaria ruziziensis para a tolerância ao alumínio. Foram utilizados 10 genótipos da espécie referida, crescidas em vasos com 0, 30 e 60 mg/L de alumínio em solução nutritiva. Foi utilizado o delineamento inteiramente casualizado em esquema fatorial, com seis repetições e parcelas de uma planta por vaso. Foram avaliados: a produção de massa verde da parte aérea e raízes (MVPA e MVR, a produção de matéria seca da parte aérea e raízes (MSPA e MSR, o incremento no crescimento da parte aérea e das raízes (IPA e IR, expresso pela diferença entre o crescimento final e o inicial, e o incremento no número de perfilhos (INP. O aumento nas concentrações de alumínio provocou decréscimos para as médias de todas as características avaliadas, excetuando o IR. A ausência de diferenças do genótipo 8 para seis das sete características analisadas, com exceção da MVPA, demonstra ser ela a mais promissora para estudos posteriores em melhoramento, visando maior produtividade em solos ácidos. Os resultados evidenciaram a existência de variabilidade genética entre os genótipos avaliados para a tolerância ao alumínio tóxico, sendo possível identificar materiais mais produtivos na presença desse metal.In acid soils, the aluminum is responsible for the low cultures productivity. The objective of this work was to evaluate the Brachiaria ruziziensis genetic variability for the aluminum tolerance.10 genotypes of that species were used, grown in vases with 0, 30 and 60 mg/L of aluminum in nutritious solution. A completely randomized design under 10 x 3 factorial, with six replicates. The following variables were evaluated: the green mass production of the aerial part and roots (MVPA and MVR, the dry matter production of the aerial part and roots (MSPA and MSR

  18. Diurnal behaviour of some salivary parameters in patients with diabetes mellitus (flow rate, pH, thiocianat, LDH activity)--note II.

    Science.gov (United States)

    Ionescu, S; Bădiţă, D; Artino, M; Dragomir, M; Huidovici, E; Niţă, V; Chiţoi, E

    1998-01-01

    The study was performed on 31 diabetic patients of both sexes, divided in 2 groups: group I--17 patients with insulin-dependent diabetes (IDDM) and group II--14 patients with noninsulin-dependent diabetes (NIDDM) and compared with a control group of 16 non-diabetic subjects. Mixed saliva was sampled without stimulation during 2 periods of the day: 07:30-08:00 before breakfast and 17:30-18:00 before dinner. We determined: salivary flow rate, pH with Merck indicator and, after homogenization, the thiocianat with the FeCl3 method and LDH activity (the Norbert method adapted in our laboratory for saliva). Our study showed the same diurnal changes in flow rate and salivary pH in both diabetic and control groups: minimal values in the morning and maximal ones in the afternoon. In non-smoking diabetic patients the salivary thiocianat had maximal values in the morning and minimal ones in the afternoon; similar behaviour, but less obvious was observed in smoking diabetic patients and in the control group regardless of the smoking habit. LDH activity showed unsignificant diurnal variations in the diabetic patients. In the control group we found a significant decrease of LDH activity in the afternoon. The discussion is about the implication of these salivary parameters in the pathology of oral cavity: gingivitis, periodontitis and caries in diabetic patients.

  19. Uveitis and diabetes mellitus

    NARCIS (Netherlands)

    Rothova, A.; Meenken, C.; Michels, R. P.; Kijlstra, A.

    1988-01-01

    Of 340 patients with anterior uveitis, 20 (6%) had diabetes mellitus. This is significantly higher than the prevalence of 1.4% in the normal Dutch population (P less than .001). Of 128 patients with idiopathic anterior uveitis, 16 (12.5%) had diabetes mellitus compared to only four (1.9%) of 212

  20. Ácidos grasos en la dieta diabetes mellitus e insulino resistencia

    Directory of Open Access Journals (Sweden)

    Clara Eugenia Pérez G.

    2006-04-01

    Full Text Available La resistencia a la insulina es característica de la diabetes mellitus tipo 2. Como parte del tratamiento se recomienda los diabéticos, sustituir en las dietas los ácidos grasos saturados y el colesterol por ácidos grasos monoinsaturados; sin que estén del todo claro los mecanismos bioquímicos que beneficiarían a los pacientes. Es probable, entre otros mecanismos, que los ácidos grasos monoin­saturados aumenten la sensibilidad a la insulina. Esta revisión analiza la relación entre el tipo de ácido graso en la dieta y la resistencia a insulina en la diabetes mellitus tipo 2.

  1. Diabetes Mellitus como causa de perda auditiva Diabetes mellitus as etiological factor of hearing loss

    Directory of Open Access Journals (Sweden)

    Clícia Adriana S. Maia

    2005-04-01

    Full Text Available Os pacientes com diabetes mellitus freqüentemente apresentam sintomas como tontura, zumbidos e hipoacusia. Via de regra, a perda auditiva é do tipo sensorioneural, confundindo-se, por vezes, com presbiacusia, principalmente por ocorrer em pacientes acima dos 40 anos de idade. A angiopatia e a neuropatia causadas pelo diabetes mellitus têm sido considerados importantes fatores responsáveis pelas manifestações vestibulococleares nesses pacientes. Porém, existe controvérsia no que se refere à etiopatogênese da perda auditiva, sendo que parte dos autores advoga que ela ocorre devido à neuropatia, outra parte à angiopatia, e outra, ainda, à associação das duas. Porém há também os que entendem que o diabetes mellitus e a perda auditiva poderiam ser partes integrantes de uma síndrome genética e não dependentes entre si. Realizamos uma extensa revisão bibliográfica procurando analisar se há relação "causa e efeito" entre o diabetes mellitus e a perda auditiva. Pudemos observar que, apesar do grande número de estudos realizados, a controvérsia ainda é grande, sendo que novas perspectivas, como no campo da genética, estão sendo estudadas, mostrando que novos rumos podem ser tomados para se chegar à conclusão do tema.Patients with diabetes mellitus often show symptoms such as dizziness, tinnitus, and hearing impairment. In general, hearing loss is sensorineural, which is sometimes confused with presbycusis, mainly because it develops in patients older than 40 years of age. Angiopathy and neuropathy caused by diabetes mellitus have been considered important factors for the vestibular-cochlear disorders found in these patients. However, there is controversy regarding the etiopathogenesis of hearing loss, as some researchers support that it develops due to neuropathy, others say it is due to angiopathy, or even a combination of both. Yet, some researchers believe diabetes mellitus and hearing loss are part of a genetic

  2. Diabetes mellitus and upper gut motility

    Directory of Open Access Journals (Sweden)

    F. Mandolfino

    2013-01-01

    Full Text Available The aim of the study is to detect the presence of esophageal motor disorders in type I and II diabetic patients, and to establish whether there is any difference between patients with and without neuropathy. 118 diabetics patients (34 type I and 84 type II were investigated by water-perfused stationary esophageal manometry. Data were correlated with the presence of peripheral neurophaty. As a result 71% of patients affected by peripheral neuropathy showed manometric abnormalities against the 37% of the patients without neuropathy. Our experience has shown that patients with diabetes mellitus frequently present esophageal symptoms and manometric abnormalities. Manometric study of the esophagus has to be considered a useful investigative tool to manage and monitorize the gastrointestinal abnormalities in patients affected by diabetes mellitus.

  3. The surgical treatment of type II diabetes mellitus: changes in HOMA Insulin resistance in the first year following laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic adjustable gastric banding (LAGB).

    Science.gov (United States)

    Ballantyne, Garth H; Wasielewski, Annette; Saunders, John K

    2009-09-01

    Bariatric operations significantly improve glucose metabolism, decrease insulin resistance, and lead to clinical resolution of type II diabetes mellitus in many patients. The mechanisms that achieve these clinical outcomes, however, remain ill defined. Moreover, the relative impact of various operations on insulin resistance remains vigorously contested. Consequently, the purpose of this study was to compare directly the impact of laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic adjustable gastric banding (LAGB) on hemoglobin A1c (HbA1c) levels and insulin resistance in comparable groups of morbidly obese patients. Data were entered prospectively into our bariatric surgery database and reviewed retrospectively. Patients selected operations. Principle outcome variables were percent excess weight loss (%EWL), HbA1c, and homeostatic model assessment for insulin resistance (HOMA IR). The number of follow-up visits for 111 LAGB patients was 263 with a median of 162 days (17-1,016) and 291 follow-up visits for 104 LRYGB patients for a median of 150 days (8-1,191). Preoperative height, weight, body mass index, age, sex, race, comorbidities, fasting glucose, insulin, HbA1c, and HOMA IR were similar for both groups. In particular, the number of patients who were diabetics and those receiving insulin and other hypoglycemic agents were similar among the two groups. The LAGB patients lost significantly less weight than the LRYGB patients (24.6% compared to 44.0% EWL). LAGB reduced HbA1c from 5.8% (2-13.8) to 5.6% (0.3-12.3). LRYGB reduced HbA1c from 5.9% (2.0-12.3) to 5.4% (0.1-9.8). LAGB reduced HOMA IR from 3.6 (0.8-39.2) to 2.3 (0-55) and LRYGB reduced HOMA IR from 4.4 (0.6-56.5) to 1.4 (0.3-15.2). Postoperative HOMA IR correlated best with %EWL. Indeed, regression equations were essentially identical for LAGB and LRYGB for drop in %EWL versus postoperative HOMA IR. Percent excess weight loss significantly predicts postoperative insulin resistance (HOMA IR

  4. Ataxia espinocerebelar tipo 6: relato de caso

    Directory of Open Access Journals (Sweden)

    Bianca Simone Zeigelboim

    2014-10-01

    Full Text Available O objetivo deste estudo foi verificar as alterações vestibulococleares observadas em um caso de ataxia espinocerebelar tipo 6. O caso foi encaminhado do Hospital de Clínicas para o Laboratório de Otoneurologia de uma Instituição de Ensino e foi submetido aos seguintes procedimentos: anamnese, inspeção otológica, avaliações audiológica e vestibular. O caso retrata uma paciente com diagnóstico genético de ataxia espinocerebelar tipo 6, do sexo feminino, com 57 anos de idade, que referiu desequilíbrio à marcha com tendência a queda para a esquerda, disartria e disfonia. Na avaliação audiológica apresentou configuração audiométrica descendente a partir da frequência de 4kHz e curva timpanométrica do tipo "A" com presença dos reflexos estapedianos bilateralmente. No exame vestibular observou-se na pesquisa da vertigem posicional presença de nistagmo vertical inferior e oblíquo, espontâneo e semiespontâneo múltiplo com características centrais (ausência de latência, paroxismo, fatigabilidade e vertigem, nistagmooptocinético abolido e hiporreflexia à prova calórica. Constataram-se alterações labirínticas que indicaram afecção do sistema vestibular central evidenciando-se a importância dessa avaliação. A existência da possível relação entre os achados com os sintomas vestibulares apresentados pela paciente apontou a relevância do exame labiríntico neste tipo de ataxia uma vez que a presença do nistagmo vertical inferior demonstrou ser frequente neste tipo de patologia.

  5. RENOPROTECTION IN DIABETES MELLITUS

    African Journals Online (AJOL)

    diabetes mellitus (DM) (Table I).1 In response to the increasing threat ... formation of reactive oxygen species (ROS); generation of advanced glycation ... There is sufficient evidence that certain therapies protect the kidneys from the long-term ...

  6. Divergência genética entre genótipos de frangos tipo caipira

    Directory of Open Access Journals (Sweden)

    R. C. Veloso

    2015-10-01

    Full Text Available RESUMOObjetivou-se com este trabalho verificar a divergência genética entre sete genótipos de frangos tipo caipira da linhagem Redbro utilizando as características de desempenho por meio de técnicas de análise multivariada. Foram utilizados 840 pintos de um dia, machos, distribuídos em delineamento inteiramente ao acaso, dos seguintes genótipos: Caboclo, Carijó, Colorpak, Gigante Negro, Pesadão Vermelho, Pescoço Pelado e Tricolor. Após a consistência dos dados, foram avaliadas as seguintes variáveis: ganho em peso médio diário, consumo de ração médio diário e conversão alimentar, para os períodos: 1 a 28, 1 a 56, 1 a 70 e 1 a 84 dias de idade; peso corporal ao nascimento, aos 28, 56, 70 e aos 84 dias de idade. O desempenho dos genótipos foi avaliado por meio da análise de variância multivariada e da função discriminante linear de Fisher, usando os testes do maior autovalor de Roy e da união-interseção de Roy para as comparações múltiplas. O estudo da divergência genética foi feito por meio da análise por variáveis canônicas e pelo método de otimização de Tocher. Os genótipos Caboclo e Gigante Negro apresentaram médias canônicas diferentes dos demais genótipos. As duas primeiras variáveis canônicas explicaram 97,41% da variação entre os genótipos. A divergência genética entre os genótipos avaliados permitiu a formação de quatro grupos com os seguintes genótipos: grupo 1 - Colorpak; grupo 2 - Pesadão Vermelho e Pescoço Pelado; grupo 3 - Carijó e Tricolor; e grupo 4 - Caboclo e Gigante Negro.

  7. Exploring the clinical utility of optical quality and fundus autofluorescence metrics for monitoring and screening for diabetes mellitus

    OpenAIRE

    Calvo Maroto, Ana María

    2017-01-01

    La Diabetes Mellitus (DM) es una enfermedad sistémica que se caracteriza por una hiperglucemia crónica asociada a daños a largo plazo de diferentes órganos, como son los ojos, riñones, corazón y vasos sanguíneos, entre otros. Normalmente, la DM se clasifica en DM tipo 1 y DM tipo 2, a los que también hay que añadir la diabetes gestacional y otros tipos de diabetes causados por factores genéticos y otras enfermedades o infecciones. La DM es una enfermedad que constituye un gran impacto soci...

  8. In vitro evaluation of marginal microleakage of class II bonded amalgam restorations using a dentin adhesive and a glass ionomer cement Avaliação in vitro da microinfiltração marginal em restaurações de amálgama tipo classe II usando adesivo dentinário e cimento de ionômero de vidro

    Directory of Open Access Journals (Sweden)

    Edmêr Silvestre PEREIRA JÚNIOR

    1999-04-01

    Full Text Available The purpose of this study was to evaluate in vitro the effectiveness of the dentin bonding system All Bond 2 associated with Resinomer (Bisco, and of Vitrebond (3M glass ionomer cement fresh-mixed, both used in the bonded amalgam technique, to prevent short-term microleakage in class II cavities restored with Dispersalloy (Dentsply, an admixed alloy. The control group utilized the Copalite (Cooley & Cooley varnish. Forty five sound human extracted premolars were used. Class II cavity preparations were made on the mesial and distal surfaces of non-carious teeth, with the gingival margins wall established 1mm under the cementum enamel junction. The specimens were divided randomly into three groups with thirty cavities in each group. The teeth were stored in distilled water for 24 hours and were thermocyled through 500 cycles in distilled water between 5°C and 55°C with a dwell time of 15 seconds. The apices and roots of the teeth were sealed. They were placed in a 37°C bath of 0.5% basic fuchsin dye for 24 hours. The teeth were washed in tap water for 24 hours and cut. The microleakage scores per restoration were averaged and three values of various test groups were subjected to the Kruskal-Wallis and Dunn test at a significance level of p O objetivo deste estudo foi avaliar in vitro a efetividade na prevenção da microinfiltração do sistema adesivo All Bond 2 associado ao Resinomer (Bisco, e do cimento de ionômero de vidro Vitrebond (3M, sem polimerização, em amálgama adesivo classe II, restauradas com Dispersalloy (Dentsply. No grupo controle utilizou-se o verniz cavitário Copalite (Cooley & Cooley. Para tanto, 45 pré-molares humanos íntegros e extraídos, com finalidade ortodôntica, receberam cavidades classe II, sendo uma na face mesial e outra na face distal de cada dente, com a parede cervical localizada a 1mm além da junção cemento-esmalte, sendo 30 cavidades em cada grupo. Após as restaurações os dentes foram estocados

  9. Psychosocial determinants of type 2 diabetes mellitus

    International Nuclear Information System (INIS)

    Afzal, S.; Amin, M.K.; Ahmad, I.; Amer, H.; Shoaib, H.; Ibrahim, H.; Tayyab, M.; Hassan, M.; Javaid, M.A.; Rehman, M.A.

    2013-01-01

    Diabetes Mellitus type 2 , formerly non-insulin-dependent diabetes mellitus (NIDDM) or adult-onset diabetes, is a metabolic disorder that is characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency1. The development of Diabetes Mellitus type 2 is associated with multiple risk factors, co-morbid medical conditions as well as psychosocial determinants. These psychosocial factors, which differ from population to population, can be identified and controlled to reduce the incidence of type 2 Diabetes Mellitus. Objective: To identify various psychosocial factors associated with type 2 Diabetes Mellitus. Design: Case-control study. Place and Duration: Diabetic clinic and Medical Units Mayo Hospital Lahore . July to December, 2012. Subjects and Methods: A population based case-control study with 1:1 case to control ratio was conducted. A total of 100 subjects (50 cases and 50 controls) having age above 35 years were recruited in the study. Selection was made on laid down criteria from patients coming to Mayo Hospital Lahore after taking consent. Interviews were conducted through a pretested questionnaire. Data was collected, compiled and analyzed through IBM SPSS version 20. Results: Out of 100 study subjects 67% were males and 33% were females. Among cases of Diabetes mellitus type 2, 64% were males, 70% in the age group 35-50 years, 96% were married, 36% were illiterates. Mean age was found 49.24, standard deviation 10.915. In bivariate analysis, Diabetes Mellitus type II was found significantly associated with Anxiety(OR: 5.348, 95% CI: 2.151-13.298) Depression(OR: 5.063, 95% CI: 1.703-15.050), High fat diet, (OR: 2.471, 95% CI: 1.100-5.547) Sedentary Lifestyle(OR: 4.529, 95% CI: 1.952-10.508) and Psychological Stress(OR:4.529, 95% CI: 1.952-10.508). However, in multivariate analysis while controlling all other risk factors, Anxiety(OR: 6.066, 95% CI: 1.918-19.191), High fat diet(OR: 3.648, 95% CI: 1

  10. O oraloma da diabetes melitos tipo 1 vs diabetes melitos tipo 2 - um estudo comparativo

    OpenAIRE

    Brás, Vítor Daniel Moreira

    2013-01-01

    A Diabetes Melitos é uma doença de grande prevalência a nível mundial e os seus mecanismos fisiopatológicos não são ainda totalmente conhecidos. Actualmente, a terapêutica seguida em casos de Diabetes Melitos é eminentemente sintomática consistindo na administração de insulina nos casos de Diabetes Melitos tipo 1 ou quando se verifica a falência das células beta do pâncreas de pacientes com Diabetes Melitos tipo 2, ou no controlo da glicemia nos casos de Diabetes Melitos ...

  11. Projeto "Diabetes Weekend": Proposta de Educação em Diabetes Mellitus Tipo 1

    OpenAIRE

    Maia, Frederico F.R.; Araújo, Levimar R.

    2002-01-01

    A educação em diabetes é parte imprescindível do tratamento do paciente, associado ao controle metabólico adequado, atividade física e dieta. O maior nível de conhecimento sobre a doença e suas complicações estão relacionadas a uma melhora da qualidade de vida, com redução do número de crises de hipoglicemia, menor número de internações hospitalares, melhor controle metabólico e maior aceitação da doença. Apresenta-se uma proposta de educação em diabetes na forma de colônia de fim de semana a...

  12. Plantas medicinales en el tratamiento de la Diabetes Mellitus Tipo 2: una revisión

    Directory of Open Access Journals (Sweden)

    Gallego Muñoz C

    2015-12-01

    Full Text Available Objetivo: El objetivo de esta revisión es proporcionar a los farmacéuticos comunitarios información práctica para orientar a los pacientes con DM2 en tratamiento con plantas medicinales. Material y método: Se realizó una búsqueda exhaustiva de la literatura publicada en las principales bases de datos hasta el 31 de marzo de 2014. Las revisiones y estudios seleccionados fueron sometidos a lectura crítica y a la evaluación de su calidad metodológica. Resultados: Los pacientes, a menudo, solicitan asesoramiento farmacéutico para el empleo de estas plantas en el tratamiento de DM2; sin embargo, no existen estudios robustos que ayuden a los farmacéuticos a ofrecer consejos con fiabilidad. Los estudios existentes incluyen pocos pacientes, están mal diseñados y los resultados son heterogéneos. Conclusión: El fenogreco o alholva posee un efecto hipoglucemiante con una fuerte evidencia científica. También existe buena evidencia en el caso de ivy gourd y gymnema en el manejo de la hiperglucemia.

  13. Meta-análisis del papel del licopeno en la diabetes mellitus tipo 2

    OpenAIRE

    Valero, M. A.; Vidal, A.; Burgos, R.; Calvo, F. L.; Martínez, C.; Luengo, L. M.; Cuerda, C.

    2011-01-01

    Introducción: El licopeno es un caroteno con un potente efecto antioxidante que se encuentra en el tomate y sus derivados. Dado que los pacientes diabéticos presentan un incremento del estrés oxidativo, el licopeno podría ser beneficioso. El objetivo de la revisión ha sido analizar la evidencia científica del papel del licopeno como antioxidante en la diabetes, en su prevención y en el control metabólico y desarrollo de complicaciones. Material y método: Se realizó una revisión sistemática y ...

  14. Efectos de la entrevista motivacional en el tratamiento de la diabetes mellitus tipo 2 /

    OpenAIRE

    García Flores, Raquel

    2012-01-01

     tesis que para obtener el grado de Doctorado en Psicología, presenta Raquel Garcia Flores ; asesor Juan José Sánchez Sosa, Samuel Jurado Cárdenas, Ana Luisa González Celis Rangel, Gilda Gómez Pérez Mitré, Javier Nieto Gutiérrez235 páginas : ilustracionesDoctorado en Psicología UNAM, Facultad de Psicología, 2012

  15. UM OLHAR SOBRE O DIABETES NA INFÂNCIA E NA JUVENTUDE: NEM TODOS SÃO TIPO 1

    Directory of Open Access Journals (Sweden)

    ANGHEBEM-OLIVEIRA

    2013-12-01

    Full Text Available O Diabetes mellitus (DM é caracterizado como um quadro de hiperglicemia crônica, que com os anos causa disfunção endotelial e sérias complicações vasculares, como a retinopatia, nefropatia e o infarto agudo do miocárdio. À medida que a ciência avança na compreensão da fisiopatologia e das características clínico-laboratoriais do diabetes, sua classificação tem sido adaptada, justamente porque a correta classificação do diabetes vai impactará no prognóstico e tratamento do paciente. Atualmente, o diabetes é classificado em DM tipo 1, DM tipo 2, DM gestacional e Outros Tipos Específicos, que inclui a categoria MODY (do inglês, Maturity Onset Diabetes of the Young ou diabetes da maturidade com início na juventude. O que esta revisão pretende mostrar é quem nem todo diabetes diagnosticado na infância e na juventude é DM tipo 1

  16. UM OLHAR SOBRE O DIABETES NA INFÂNCIA E NA JUVENTUDE: NEM TODOS SÃO TIPO 1

    Directory of Open Access Journals (Sweden)

    Mauren Isfer ANGHEBEM-OLIVEIRA

    2013-04-01

    Full Text Available O Diabetes mellitus (DM é caracterizado por um quadro de hiperglicemia crônica, que com os anos pode causar disfunção endotelial e sérias complicações vasculares, como a retinopatia, nefropatia e o infarto agudo do miocárdio. À medida que a ciência avança na compreensão da fisiopatologia e das características clínico-laboratoriais do diabetes, sua classificação tem sido adaptada, justamente porque a correta classificação do diabetes impacta no prognóstico e tratamento do paciente. Atualmente, o diabetes é classificado em DM tipo 1, DM tipo 2, DM gestacional e Outros Tipos Específicos, que inclui a categoria MODY (do inglês, Maturity Onset Diabetes of the Young ou diabetes da maturidade com início na juventude. O que esta revisão pretende mostrar é quem nem todo diabetes diagnosticado na infância e na juventude é DM tipo 1. O correto diagnóstico e classificação do DM são fundamentais, uma vez que o prognóstico e o tratamento podem diferir dependendo da causa que predispôs a criança ou adolescente à doença.

  17. Hábitos alimentares, hiperhomocisteinémia e doença cardiovascular na diabetes do tipo 2

    OpenAIRE

    Valente, Ana Margarida Saraiva

    2014-01-01

    Tese de doutoramento em Ciências e Tecnologias da Saúde (Nutrição), apresentada à Faculdade de Medicina da Universidade de Lisboa, 2013. Helena Soares Costa: Departamento de Alimentação e Nutrição do INSA. [PT] INTRODUÇÃO: A diabetes mellitus é uma doença crónica com elevados custos sociais, humanos e económicos. É actualmente considerada um dos maiores problemas de saúde pública e só em Portugal existem mais de um milhão de diabéticos. A diabetes mellitus tipo 2 e a alteração...

  18. Trastornos alimentarios en pacientes diabéticos tipo 1 : causas y efectos en la adherencia al tratamiento

    OpenAIRE

    Miramontes Fandiño, Minia María

    2012-01-01

    El diagnóstico de Diabetes Mellitus tipo 1 en un adolescente es un acontecimiento vital estresante que puede producir una crisis personal y familiar. El adolescente en ocasiones puede presentar una negación de la enfermedad, no asumiendo los auto-cuidados higiénico-dietéticos, con una inadecuada adhesión al tratamiento y rechazo a la ayuda familiar y sanitaria, a pesar de conocer y estar formados en su terapéutica y las consecuencias del no-cumplimiento como las complicaciones ...

  19. Manejo práctico del paciente con diabetes mellitus en la Atención Primaria de Salud

    Directory of Open Access Journals (Sweden)

    Belkis Vicente Sánchez

    2011-12-01

    Full Text Available La diabetes mellitus es una enfermedad de primera importancia a nivel de salud pública en todo el mundo, por ser una de las enfermedades no transmisibles más frecuentes, y por la severidad y diversidad de sus complicaciones crónicas. Se realiza una revisión actualizada sobre el manejo de las personas con diabetes mellitus. Incluye definición, diagnóstico y clasificación, algoritmo para el pesquisaje de la enfermedad, conducta ante una persona con diabetes mellitus en la Atención Primaria de Salud, pilares de tratamiento y metas de control metabólico. Tiene como objetivo exponer elementos prácticos para el abordaje del paciente con diabetes mellitus tipo.Practical Management of Patients with Diabetes Mellitus in Primary Health CareDiabetes mellitus is a disease of major importance for public health throughout the world. This is mainly caused by its status as one of the most common non-communicable diseases and the severity and diversity of its chronic complications. An updated literary review on the management of patients with diabetes mellitus was conducted. It includes definition, diagnosis and classification, algorithm for disease’s screening, appropriate management of a patient with diabetes mellitus in primary health care, treatment pillars and goals for metabolic control. This review is aimed at exposing practical elements when approaching a patient suffering from diabetes mellitus.

  20. [Nasal mucosa in patients with diabetes mellitus].

    Science.gov (United States)

    Müller, Maciej; Betlejewski, Stanisław

    2003-01-01

    Diabetes mellitus is the most common endocrinologic disease all over the world. 150 million people suffer from this disease, in Poland about 2 million. The disease on the basis of the onset and pathophysiology may be divided into type I and type II. Pathophysiologic changes include diabetic microangiopathy, macroangiopathy and neuropathy. The most common presentations in head and neck are otitis externa, hypoacusis, vertigo, disequilibrium, xerostomia, dysphagia, fungal and recurrent infections. The changes in nasal mucosa are not very well known. Only few papers concerned the problem. The main complaints of patients regarding the nose are xeromycteria, hyposmia and various degree of decreased patency of the nose. Chronic atrophic rhinitis, septal perforation, ulceration of nasal mucosa, alar necrosis, symptoms of staphylococcal or fungal infection can be found during otolaryngologic examination. The treatment in this group of patients should consist of systemic therapy of diabetes mellitus and on the other hand focal therapy with the use of a solution to moisten the nasal mucosa.

  1. The prevalence of microalbuminuria among patients with type II ...

    African Journals Online (AJOL)

    This cross-sectional community-based study was carried out to determine the prevalence of microalbuminuria among patients with type II diabetes mellitus in a primary care setting, and to study the association between various risk factors and the presence of microalbuminuria. All patients with type II diabetes mellitus who ...

  2. The Therapeutic Effect of Zuogui Wan in Gestational Diabetes Mellitus Rats

    Science.gov (United States)

    Feng, Qianjin; Niu, Xin; Liu, Xinshe; Xu, Kaixia; Yang, Xiangzhu; Wang, Huifeng

    2014-01-01

    In this experiment, we established an animal model of gestational diabetes mellitus rats using streptozotocin. Using the rat model of GDM, the pregnant rats in 1-19d were divided into three groups: (1) Zuogui Wan gestational diabetes mellitus group (group I, n = 12), (2) gestational diabetes mellitus rats as the control group (group II, n = 11), and (3) rats of normal pregnancy group (group III, n = 11). Compared with gestational diabetes mellitus rats as the control group, Zuogui Wan can change the indexes of fasting blood glucose, body weight, total cholesterol, insulin, and metabolism cage index significantly in Zuogui Wan gestational diabetes mellitus group. We can conclude that Zuogui Wan has the therapeutic effect on gestational diabetes mellitus. PMID:25136475

  3. Diabetes mellitus and Parkinson disease.

    Science.gov (United States)

    Pagano, Gennaro; Polychronis, Sotirios; Wilson, Heather; Giordano, Beniamino; Ferrara, Nicola; Niccolini, Flavia; Politis, Marios

    2018-05-08

    To investigate whether diabetes mellitus is associated with Parkinson-like pathology in people without Parkinson disease and to evaluate the effect of diabetes mellitus on markers of Parkinson pathology and clinical progression in drug-naive patients with early-stage Parkinson disease. We compared 25 patients with Parkinson disease and diabetes mellitus to 25 without diabetes mellitus, and 14 patients with diabetes mellitus and no Parkinson disease to 14 healthy controls (people with no diabetes mellitus or Parkinson disease). The clinical diagnosis of diabetes mellitus was confirmed by 2 consecutive fasting measurements of serum glucose levels >126 mL/dL. Over a 36-month follow-up period, we then investigated in the population with Parkinson disease whether the presence of diabetes mellitus was associated with faster motor progression or cognitive decline. The presence of diabetes mellitus was associated with higher motor scores ( p Parkinson disease. In patients with diabetes but without Parkinson disease, the presence of diabetes mellitus was associated with lower striatal dopamine transporter binding ( p Parkinson disease, the presence of diabetes mellitus was associated with faster motor progression (hazard ratio = 4.521, 95% confidence interval = 1.468-13.926; p Parkinson-like pathology, and when present in patients with Parkinson disease, can induce a more aggressive phenotype. © 2018 American Academy of Neurology.

  4. Estereótipos e mulheres na cultura marroquina

    OpenAIRE

    Sadiqi,Fatima

    2008-01-01

    Estereótipos sobre as mulheres no Marrocos podem ser caracterizados como crenças culturais incompletas e inexatas mantidas por algumas pessoas e que se encontram inscritos em expressões lingüísticas ou em discursos subliminares. A cultura popular marroquina emprega representações poderosas para transmitir e sustentar tais estereótipos. Embora existam alguns estereótipos positivos, a maioria dos estereótipos sobre as mulheres no Marrocos é negativa e reflete ditames patriarcais subliminares qu...

  5. [Prevalence of the Diabetic Retinopathy and Genetic Factors Significance in the Development of Diabetic Retinopathy in Patients with Diabetes Mellitus type I and II in Slovakia (DIARET SK study). Overview of Actual Findings and Design of the Epidemiological DIARET SK Study].

    Science.gov (United States)

    Krásnik, V; Štefaničková, J; Fabková, J; Bucková, D; Helbich, M

    2015-09-01

    Diabetic retinopathy (DR) is the second most common microvascular complication and the most common cause of blindness in patients with diabetes mellitus (DM). Despite the ongoing research, the findings of diabetic retinopathy epidemiological and risk factors are, until now, not consistent. More finding may be revealed by epidemiological studies, consistently mapping DR epidemiology under the current possibilities of investigations and treatment of the DM. DIARET SK Study, with 5 000 enrolled patients with diabetes mellitus in the Slovak Republic, is, until now, the largest epidemiological study to set the prevalence of diabetic retinopathy. The primary aim is to establish the prevalence of diabetic retinopathy in patients with diabetes mellitus type I and II, according to the duration of the disease. The secondary aim is to establish prevalence of the different stages of the DR and diabetic macular edema (DME) and analysis of the risk factors influence. Included are patients with DM type I and II regardless to the ocular complications history and the period of DM duration. Each enrolled patient has both complex diabetic and ophthalmic examinations.Projects to establish DR prevalence: Tens of projects concerned with diabetic retinopathy epidemiology with different approaches to establish the prevalence and with different patients population. Results from different studies vary significantly (from 12.3 % to 66.9 %). The results depend on the design of the study and the patients recruitment, used examination methods, specific patients population with regard to the geography, prevalence of risk factors, period of diabetes duration, glycated hemoglobin (HbA1C) level, blood pressure, and is higher in type I diabetic patients. The most accurate results are from population epidemiological studies with well-controlled patient recruitment and uniform complex examination that are similar to the DIARET SK study. The DIARET SK study represents the largest epidemiological study

  6. Recent advances in the Management of Diabetes Mellitus | Sanusi ...

    African Journals Online (AJOL)

    Life style modi cation, oral hypoglycaemic agents, insulin therapy and islet cell transplantation are some of the approaches in the management of diabetes mellitus. Several classes of oral hypoglycemic agents like sulfonylureas, biguanides and alpha-glucosidase inhibitors are available for the treatment of type II diabetes ...

  7. Diabetes Mellitus Coding Training for Family Practice Residents.

    Science.gov (United States)

    Urse, Geraldine N

    2015-07-01

    Although physicians regularly use numeric coding systems such as the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) to describe patient encounters, coding errors are common. One of the most complicated diagnoses to code is diabetes mellitus. The ICD-9-CM currently has 39 separate codes for diabetes mellitus; this number will be expanded to more than 50 with the introduction of ICD-10-CM in October 2015. To assess the effect of a 1-hour focused presentation on ICD-9-CM codes on diabetes mellitus coding. A 1-hour focused lecture on the correct use of diabetes mellitus codes for patient visits was presented to family practice residents at Doctors Hospital Family Practice in Columbus, Ohio. To assess resident knowledge of the topic, a pretest and posttest were given to residents before and after the lecture, respectively. Medical records of all patients with diabetes mellitus who were cared for at the hospital 6 weeks before and 6 weeks after the lecture were reviewed and compared for the use of diabetes mellitus ICD-9 codes. Eighteen residents attended the lecture and completed the pretest and posttest. The mean (SD) percentage of correct answers was 72.8% (17.1%) for the pretest and 84.4% (14.6%) for the posttest, for an improvement of 11.6 percentage points (P≤.035). The percentage of total available codes used did not substantially change from before to after the lecture, but the use of the generic ICD-9-CM code for diabetes mellitus type II controlled (250.00) declined (58 of 176 [33%] to 102 of 393 [26%]) and the use of other codes increased, indicating a greater variety in codes used after the focused lecture. After a focused lecture on diabetes mellitus coding, resident coding knowledge improved. Review of medical record data did not reveal an overall change in the number of diabetic codes used after the lecture but did reveal a greater variety in the codes used.

  8. Use of pectin in patients with diabetes mellitus type 2 in the complex treatment of the periodontal disease (report 2)

    OpenAIRE

    S. V. Kosenko; I. O. Balaban; O. B. Hayoshko; O. M. Ilnytska; N. M. Yatsynovych; S. O. Ivanov; N. I. Muzichenko

    2014-01-01

    Introduction. According the literature problem of the treatment of patients with periodontal tissues pathology, accompanied by diabetes mellitus, is serious and is not always successfully solved. Drugs that inhibit glucose absorption (polysugars) are effective in diabetes mellitus. "Pektodent" (Ukraine) applying in the treatment and prevention of chronic generalized periodontitis of II-III degree in patients with diabetes mellitus type 2 can be appropriate in this case. The objective of ...

  9. Incertidumbre en adultos diabéticos tipo 2 a partir de la teoría de Merle Mishel

    Directory of Open Access Journals (Sweden)

    Isabel Patricia Gómez-Palencia

    2015-01-01

    Full Text Available Objetivo: describir el nivel de incertidumbre de adultos con diabetes mellitus tipo 2 atendidos en instituciones prestadoras de servi- cios de salud en Cartagena (Colombia. Materiales y métodos: estudio descriptivo a partir de una muestra de 163 pacientes que tuvieran como mínimo dos meses de haber sido diagnosticados con diabetes mellitus tipo 2. El instrumento utilizado fue la escala de la Incerti- dumbre ante la enfermedad de Mishel y para el análisis de los datos fue utilizado el paquete estadístico SPSS versión 20.0. Resultados: del total de participantes 76,1 % mostraron un nivel de incertidumbre regular. El fenómeno de la incertidumbre está más relacionado con la incapacidad para identificar si ha mejorado o no (86,5 % , de predecir o explicar la causa de un malestar físico (76,7 % o predecir el cambio de los síntomas (60,1 % . Conclusiones: para enfermería, abarcar este fenómeno permite una mejor aproximación al análisis de los desafíos y las expectativas de quienes viven con una enfermedad crónica y así proporcionar cuidados que permitan un proceso de adaptación óptimo, que apoyen y enriquezcan la práctica enfermera.

  10. Comprometimento medular por linfoma tipo Burkitt: relato de um caso

    Directory of Open Access Journals (Sweden)

    Murillo Côrtes Drummond

    1985-06-01

    Full Text Available Registro de caso de linfoma tipo Burkitt com comprometimento intrarraqueano em criança de três anos de idade. Considerações sobre esse tipo de tumor são feitas em função do caso observado e de dados da literatura.

  11. Diabetes Mellitus and Hypertension

    OpenAIRE

    Tuğrul, Armağan

    2014-01-01

    Hypertension is a major worldwide health problem. Its prevalence is 1.5-2 times higher in diabetic population than that in non-diabetic individuals. Its pathogenesis depends on diabetic nephropathy in type 1, whereas may be multifactorial in type 2 diabetes mellitus. In diabetics, angiotensin converting enzyme inhibitors are most widely preferred in the treatment of hypertension because of their numerous desirable effects. In this article, the most recent data are presented on the relationshi...

  12. Efeito do uso da farinha desengordurada do Sesamum indicum L nos níveis glicêmicos em diabéticas tipo 2

    Directory of Open Access Journals (Sweden)

    Angela Siqueira Figueiredo

    Full Text Available Existe um incremento nas pesquisas de plantas e grãos com atividades hipoglicemiantes para prevenção e terapêutica do Diabetes Mellitus, que aumenta em grandes proporções mundialmente. Este estudo avalia o efeito do uso da farinha desengordurada do Sesamum indicum L. nos níveis glicêmicos de diabéticas tipo II submetidas a tratamento dietoterápico. Ensaio clínico controlado e aberto, em dois grupos, experimental (GE e controle (GC com avaliação na linha de base (AB, aos 30 (A-30 e 60 dias (A-60. As características gerais não apresentaram diferenças estatísticas entre os grupos. Observou-se diferença estatística significativa na glicemia de jejum (GJ (p = 0,004 na AB, na GJ (p = 0,002 e peso (p = 0,020 na A30, e apenas no peso (p = 0,011 na A60. Nas glicemias pós-prandiais (GP e hemoglobinas glicosiladas não houve diferença estatística em nenhuma das avaliações entre os grupos. Evidenciou-se diferença estatística entre a AB - A30 em relação ao peso nos dois grupos, e na AB - A60 na GP (p = 0,04 e peso (p = 0,01 no GE, mas apenas no peso (p = 0,03 no GC. A farinha de gergelim contribuiu no controle glicêmico e no peso em pacientes diabéticas, de forma econômica, saborosa e saudável.

  13. Lesao óssea em leucemias agudas linfoblásticas tipo T e TIPO nao T / nao B

    OpenAIRE

    Martins, Fernando Lopes

    2013-01-01

    Resumo: O AUTOR APRESENTA OS RESULTADOS DO ESTUDO RADIOLÓGICO DE ESQUELETO DE 61 PACIENTES PORTADORES DE LEUCEMIA AGUDA LINFOBLÁSTICA, CORRELACIONANDO A PRESENÇA OU NÃO DE Lesões ÓSSEAS COM A CLASSIFICAÇÃO IMUNOLÓGICA DE LAL TIPO T E TIPO não T / não B

  14. Tipos especiales de niños

    Directory of Open Access Journals (Sweden)

    Mercedes Rodrigo Bellido

    1946-09-01

    Full Text Available En las tres últimas lecciones han sido expuestas algunas consideraciones referentes a niños y adolescentes desde el nacimiento hasta el dintel de la juventud. En todas ellas hemos procurado poner de relieve la necesidad de individualizar el conocimiento de cada niño para obtener mejores resultados en su adaptación a su futura vida de adultos, En todas ellas  nos hemos referido al llamado niño normal. Nos corresponde en la lección de hoy ocuparnos can la superficialidad característica de estas charlas tipo-muestrario, de otras categorías de niños muy dignos de interés.. quienes unas por exceso, otros por defecto, otros por dificultades de adaptación por diferentes causas, se desvían de la línea media de la normalidad. Consideramos que no está fuera del lugar, aquí, el tema de los niños excepcionales y por el contrario que es necesario intensificar el estudio de los trastornos de la vida mental y emocional de los niños en la preparación de los estudiantes de Medicina. Y no es nuestra solo esta opinión; no hace mucho tiempo en la Medical School de Ia Universidad de Minnessota hemos sabido que se ha hecho un intento de considerar y evaluar factores emocionales ambientales sobre las mismas bases que los descubrimientos fisiológicos.

  15. NUEVOS FÁRMACOS EN DIABETES MELLITUS

    Directory of Open Access Journals (Sweden)

    DRA. Carmen Gloria Aylwin H.

    2016-03-01

    Full Text Available Por más de 60 años se dispuso solo de tres grupos farmacológicos para el tratamiento de la diabetes mellitus (DM: la insulina, la metformina y las sulfonilureas. Sin embargo, en los últimos años y como consecuencia de los avances en el conocimiento de la patogenia de la DM2 se han desarrollado nuevos fármacos con novedosos mecanismos de acción y con diferentes perfiles de seguridad, entre ellos los compuestos con efecto incretina y los glucosúricos que actúan en los trastornos a nivel intestinal y renal presentes en la DM2. La disponibilidad de múltiples opciones terapéuticas está produciendo profundos cambios en la terapia farmacológica de la DM2. Se logran enfoques terapéuticos más fisiopatológicos pero sobre todo permiten un manejo más personalizado y ajustado a las características y riesgos individuales de los pacientes, privilegiando junto al control glicémico, la seguridad terapéutica. En esta revisión se analizarán los nuevos fármacos con efecto incretina, los agonistas del péptido similar al glucagón tipo 1 (AR-GLP1 e inhibidores de la dipeptidil peptidasa 4 (IDPP-4, y los inhibidores de los cotransportadores sodio-glucosa tipo 2 (ISLGT2 que aumentan la excreción renal de glucosa.

  16. Heart rate variability based on risk stratification for type 2 diabetes mellitus.

    Science.gov (United States)

    Silva-E-Oliveira, Julia; Amélio, Pâmela Marina; Abranches, Isabela Lopes Laguardia; Damasceno, Dênis Derly; Furtado, Fabianne

    2017-01-01

    To evaluate heart rate variability among adults with different risk levels for type 2 diabetes mellitus. The risk for type 2 diabetes mellitus was assessed in 130 participants (89 females) based on the questionnaire Finnish Diabetes Risk Score and was classified as low risk (n=26), slightly elevated risk (n=41), moderate risk (n=27) and high risk (n=32). To measure heart rate variability, a heart-rate monitor Polar S810i® was employed to obtain RR series for each individual, at rest, for 5 minutes, followed by analysis of linear and nonlinear indexes. The groups at higher risk of type 2 diabetes mellitus had significantly lower linear and nonlinear heart rate variability indexes. The individuals at high risk for type 2 diabetes mellitus have lower heart rate variability. Avaliar a variabilidade da frequência cardíaca em adultos com diferentes níveis de risco para diabetes mellitus tipo 2. O grau de risco para diabetes mellitus tipo 2 de 130 participantes (41 homens) foi avaliado pelo questionário Finnish Diabetes Risk Score. Os participantes foram classificados em baixo risco (n=26), risco levemente elevado (n=41), risco moderado (n=27) e alto risco (n=32). Para medir a variabilidade da frequência cardíaca, utilizou-se o frequencímetro Polar S810i® para obter séries de intervalo RR para cada indivíduo, em repouso, durante 5 minutos; posteriormente, realizou-se análise por meio de índices lineares e não-lineares. O grupo com maior risco para diabetes mellitus tipo 2 teve uma diminuição significante nos índices lineares e não-lineares da variabilidade da frequência cardíaca. Os resultados apontam que indivíduos com risco alto para diabetes mellitus tipo 2 tem menor variabilidade da frequência cardíaca. To evaluate heart rate variability among adults with different risk levels for type 2 diabetes mellitus. The risk for type 2 diabetes mellitus was assessed in 130 participants (89 females) based on the questionnaire Finnish Diabetes Risk Score

  17. Diagnosing diabetes mellitus in patients with porphyria cutanea tarda

    DEFF Research Database (Denmark)

    Christiansen, Anne L.; Bygum, Anette; Hother-Nielsen, Ole

    2018-01-01

    The prevalence of diabetes mellitus is increased in patients with porphyria cutanea tarda. Different tests are available for diagnosing and screening for type II diabetes mellitus, however choosing the most suitable test is challenging. The pitfalls in the different tests along with the interfering...... comorbidities and treatments concerning patients with porphyria cutanea tarda complicate diagnosing these patients with diabetes mellitus. HbA1c, fasting glucose, or oral glucose tolerance are the current available tests, with HbA1c as first choice. Measuring HbA1c requires no fasting, however HbA1c can...... be false low if the patient is treated with phlebotomy or has liver cirrhosis or chronic hepatitis. Instead fasting glucose and oral glucose tolerance tests can be used if the patient is not acutely ill. If either of the tests give a result in the diagnostic range, the test should be repeated...

  18. Diabetes mellitus during pregnancy: a study of fifty cases

    International Nuclear Information System (INIS)

    Randhawa, M. S.; Moin, S.; Shoaib, F.

    2003-01-01

    To review and critically evaluated the incidence, epidemiology, clinical pattern, diagnosis, management, complications and outcome of diabetes mellitus during pregnancy in hospital based study. Results: Total number of women delivered were 11271. Fifty cases of diabetes mellitus during pregnancy were studied. Mostly the patients were more than 30 years of age, multiparous ladies with gestational diabetes in 80% of cases, Type-II diabetes in 16% and only in 4% Type-I diabetes was reported. Insulin was required in 40% of patients. Eight women out of 50 had spontaneous miscarriage, 5 underwent preterm delivery while 36 reached term with one intrauterine death. Total number of babies delivered alive were 41. There was one stillbirth and 3 neonatal deaths. Conclusion: Management of diabetes mellitus in pregnancy involves teamwork of obstetricians, physicians and neonatologists. (author)

  19. CARDIAC REHABILITATION IN PATIENTS WITH DIABETES MELLITUS

    Directory of Open Access Journals (Sweden)

    Marzieh Saeidi

    2010-12-01

    Full Text Available AbstractINTRODUCTION: Prevalence of cardiovascular diseases (CVD is 19.4% in Iran anddiabetes mellitus is an important CVD risk factor in this country. Non-insulin-dependentdiabetes mellitus (type II DM is associated with increased morbidity and mortality due toatherosclerosis. With cardiac rehabilitation (CR we can modify CVD risk factors such astype II DM and play an important role in decreasing its mortality and morbidity. Weinvestigated the effects of CR on cardiac patients with and without type II DM.METHODS: In this retrospective before-and-after study we analyzed data from 496 cardiacpatients (419 with type II DM and 77 without type II DM. All of the subjects completeddemographic data questionnaires and underwent weight and height measurement, exercisetest to assess exercise capacity (EC, echocardiography, and blood test to assess lipidprofile and fasting blood glucose. The subjects then participated in a 24-session CRprogram. Each session consisted of 10 minutes warm-up, 40 minutes aerobic exercise, 10minutes cool-down and 20 minutes relaxation. They also took part in 8 educational sessionson life style modification, diet therapy and stress management supervised by CR team (acardiologist, a physician, a physiotherapist, a nurse, a nutritionist and a psychiatrist. At theend of the program, all measurements, exams and tests were repeated. Data were analyzedwith SPSS11.5 using independent t-test at level of P<0.05.RESULTS: We studied 419 non-diabetics (mean age: 55.61±9.41 years and 77 diabetics(mean age: 58.59±7.76 years. Mean EC increased significantly after CR in both groups. Inthe diabetic group, EC increased significantly compared to the non-diabetic group(62.21±133.40 vs. 33.68±31/42, P=0.02. Mean levels of triglyceride, cholesterol, LDLcholesterol,as well as body mass index and heart rate decreased significantly after CR inboth groups. However, no significant difference was seen between the two groups in respectof these variables

  20. Nuevo tipo de apoyos y articulaciones

    Directory of Open Access Journals (Sweden)

    Andrä, Fritz Leonhardt

    1963-11-01

    of theoretical and technical difficulties inherent in these bearings: they also express acknowledgement to German individuals and institutions, for their contribution to this investigation.Las tendencias actuales son funciones que dependen directamente de la presencia creciente y mejorada de los materiales de construcción que se ofrecen al comercio. En el campo de los materiales cabe una marcada subdivisión en naturales y preparados o sintéticos; estos últimos constituyen la preocupación de los autores para su aprovechamiento y adecuada aplicación. De entre ellos, las resinas sintéticas o caucho artificial, dentro de las distintas especies de la extensa familia han gozado de un lugar preferente en este estudio de nuevos tipos de apoyos que presentan los notables ingenieros alemanes Wolfhart Andrä y Fritz Leonhardt. En los ensayos de laboratorio y a escala natural, las variedades comerciales de estas resinas, conocidas con los nombres de «neopreno» y «Teflon», han sido elegidas por presentar, por lo menos actualmente, características marcadamente apropiadas a la finalidad perseguida en este estudio, del que se confía ulterior desarrollo y mejor acogida, por las importantes aplicaciones que de él se derivan en el campo de la ingeniería y construcción. Los autores estudian con detenimiento y sobrado rigor para las aplicaciones prácticas las deformaciones que de estos materiales se espera al someterlos a fuerzas de gran concentración. En los apoyos juega particular interés la distribución de la carga siempre concentrada en superficies relativamente pequeñas, lo que exige elevadas cargas unitarias y, con ello, la utilización de materiales extremadamente nobles para resistirlas con la resistencia que las deformaciones instantáneas requieren para recobrar rápidamente la posición de estabilidad perdida momentáneamente. La fatiga en el ciclo de deformaciones relaja los materiales, y ha de tenerse presente al considerar las características que los

  1. Defining the research agenda to reduce the joint burden of disease from diabetes mellitus and tuberculosis

    DEFF Research Database (Denmark)

    Harries, Anthony D; Murray, Megan B; Jeon, Christie Y

    2010-01-01

    diseases, to address research gaps and to develop a research agenda. Ten key research questions were identified, of which 4 were selected as high priority: (i) whether, when and how to screen for TB in patients with diabetes mellitus and vice versa; (ii) the impact of diabetes mellitus and non......The steadily growing epidemic of diabetes mellitus poses a threat for global tuberculosis (TB) control. Previous studies have identified an important association between diabetes mellitus and TB. However, these studies have limitations: very few were carried out in low-income countries, with none...... and monitoring tests, including measurements of blood glucose and glycated haemoglobin A(1c) (HbA(1c)) for patients with diabetes mellitus. Implementation of this research agenda will benefit the control of both diseases....

  2. A randomized, double-blind, placebo-controlled, phase II clinical trial to investigate the efficacy and safety of oral DA-1229 in patients with type 2 diabetes mellitus who have inadequate glycaemic control with diet and exercise.

    Science.gov (United States)

    Jung, Chang Hee; Park, Cheol-Young; Ahn, Kyu-Joeng; Kim, Nan-Hee; Jang, Hak-Chul; Lee, Moon-Kyu; Park, Joong-Yeol; Chung, Choon-Hee; Min, Kyung-Wan; Sung, Yeon-Ah; Park, Jeong-Hyun; Kim, Sung Jin; Lee, Hyo Jung; Park, Sung-Woo

    2015-03-01

    DA-1229 is a novel, potent and selective dipeptidyl peptidase-4 (DPP-IV) inhibitor that is orally bioavailable. We aimed to evaluate the optimal dose, efficacy and safety of DA-1229, in Korean subjects with type 2 diabetes mellitus suboptimally controlled with diet and exercise. We enrolled 158 patients (mean age, 53 years and a mean BMI, 25.6 kg/m(2) ). The mean baseline fasting plasma glucose level, HbA1c and duration of diabetes were 8.28 mmol/L, 7.6% (60 mmol/mol) and 3.9 years, respectively. After 2 or 6 weeks of an exercise and diet program followed by 2 weeks of a placebo period, the subjects were randomized into one of four groups for a 12-week active treatment period: placebo, 2.5, 5 or 10 mg of DA-1229. All three doses of DA-1229 significantly reduced HbA1c from baseline compared to the placebo group (-0.09 in the placebo group vs. -0.56, -0.66 and -0.61% in 2.5, 5 and 10-mg groups, respectively) but without any significant differences between the doses. Insulin secretory function, as assessed by homeostasis model assessment β-cell, the insulinogenic index, 2-h oral glucose tolerance test (OGTT) C-peptide and post-OGTT C-peptide area under the curve (AUC)0-2h, significantly improved with DA-1229 treatment. The incidence of adverse events was similar between the treatment groups and DA-1229 did not affect body weight or induce hypoglycaemic events. DA-1229 monotherapy (5 mg for 12 weeks) improved HbA1c, fasting plasma glucose level, OGTT results and β-cell function. This drug was well tolerated in Korean subjects with type 2 diabetes mellitus. © 2014 The Authors. Diabetes/Metabolism Research and Reviews published by John Wiley & Sons, Ltd.

  3. Cardiovascular consequences of diabetes mellitus

    NARCIS (Netherlands)

    C.A. Baan (Caroline)

    1999-01-01

    textabstractDiabetes mellitus comprises a clinically and genetically heterogeneous group of disorders that have one common feature: abnormally high levels of glucose in the blood. The most common form is non-insulin dependent diabetes mellitus (NlDDM); about 80-90% of all diabetic patients has

  4. Type 2 diabetes mellitus

    DEFF Research Database (Denmark)

    DeFronzo, Ralph A; Ferrannini, Ele; Groop, Leif

    2015-01-01

    Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular complications (including retinopathy, nephropathy and neuropathy) and macrovascular complications (such as cardiovascular...... that multiple antidiabetic agents, used in combination, will be required to maintain normoglycaemia. The treatment must not only be effective and safe but also improve the quality of life. Several novel medications are in development, but the greatest need is for agents that enhance insulin sensitivity, halt...

  5. Gestational Diabetes Mellitus

    DEFF Research Database (Denmark)

    McIntyre, H David; Jensen, Dorte M; Jensen, Richard C

    2018-01-01

    OBJECTIVE: To define the prevalence and pregnancy outcomes related to elevated fasting venous plasma glucose (FVPG) in a Danish pregnancy cohort. RESEARCH DESIGN AND METHODS: This was an observational cohort study including 1,516 women without gestational diabetes mellitus (GDM) by Danish criteria....... FVPG measured at 28 weeks' gestation was related to pregnancy outcomes. RESULTS: With use of the World Health Organization 2013 threshold of FVPG ≥5.1 mmol/L, 40.1% of the cohort qualified as having GDM. There was no evidence of excess fetal growth, hypertension in pregnancy, or caesarean delivery...

  6. Pharmacogenomics in diabetes mellitus

    DEFF Research Database (Denmark)

    Zhou, Kaixin; Pedersen, Helle Krogh; Dawed, Adem Y.

    2016-01-01

    . We highlight mechanistic insights from the study of adverse effects and the efficacy of antidiabetic drugs. The identification of extreme sulfonylurea sensitivity in patients with diabetes mellitus owing to heterozygous mutations in HNF1A represents a clear example of how pharmacogenetics can direct...... patient care. However, pharmacogenomic studies of response to antidiabetic drugs in T2DM has yet to be translated into clinical practice, although some moderate genetic effects have now been described that merit follow-up in trials in which patients are selected according to genotype. We also discuss how...

  7. EMPLEO DEL MÉTODO BIOALBERIC EN EL TRATAMIENTO DE LA DIABETES MELLITUS EN CANINOS DOMÉSTICOS / Use of BioAlberic method for treating diabetes mellitus in domestic dogs

    OpenAIRE

    Yailyn Ramos Morejón; Lázaro Pérez Ramos; Aimée Álvarez Álvarez; Raisa Olano Justiniani; Jesús A. Ramírez López; Deneb González Rodríguez; Beatriz Hugues Hernandorena

    2013-01-01

    Resumen: La diabetes mellitus es una enfermedad frecuente en los caninos domésticos, en la cual pueden presentarse alteraciones del sistema cardiovascular, difíciles de tratar. Una de las vías alternativas de tratamiento en este tipo de animales pudiera ser el empleo del método BioAlberic. En este artículo se presentan los resultados obtenidos en la aplicación de este método (con el producto Rapsul) al iniciar el tratamiento de la diabetes mellitus en dos perros domésticos, como parte del pro...

  8. Modification of the metabolic parameters and microalbuminuria in patients with diabetes mellitus type 2 treated with acarbose

    OpenAIRE

    González Sarmiento, E.; Ergueta Martín, P.; Fernández Martínez, I.; Hinojosa Mena-Bernal, M.C.; Zurro Muñoz, I.; Zurro Hernández, J.

    2001-01-01

    Objetivo: Determinar la influencia de la acarbosa en la microalbuminuria y parámetros metabólicos en pacientes con diabetes mellitus tipo 2. Material y métodos: Hemos estudiado 92 pacientes con diabetes tipo 2, tratados con acarbosa, sola o con insulina o antidiabéticos orales. Hemos determinado los valores de Hb A1c, colesterol total, colesterol HDL, colesterol LDL, triglicéridos y microalbuminuria, antes y después del tratamiento con acarbosa. Resultados: Los pacientes presentaron de forma ...

  9. Protótipo do primeiro interferômetro brasileiro - BDA

    Science.gov (United States)

    Cecatto, J. R.; Fernandes, F. C. R.; Neri, J. A. C. F.; Bethi, N.; Felipini, N. S.; Madsen, F. R. H.; Andrade, M. C.; Soares, A. C.; Alonso, E. M. B., Sawant, H. S.

    2004-04-01

    A interferometria é uma poderosa ferramenta usada para investigar estruturas espaciais de fontes astrofísicas fornecendo uma riqueza de detalhes inatingível pelas técnicas convencionais de imageamento. Em particular, a interferometria com ondas de rádio abre o horizonte de conhecimento do Universo nesta ampla banda do espectro eletromagnético, que vai de cerca de 20 kHz até centenas de GHz já próximo ao infravermelho, e que está acessível a partir de instrumentos instalados em solo. Neste trabalho, apresentamos o interferômetro designado por Arranjo Decimétrico Brasileiro (BDA). Trata-se do primeiro interferômetro a ser desenvolvido no Brasil e América Latina que já está em operação na fase de protótipo. Apresentamos o desenvolvimento realizado até o momento, o sítio de instalação do instrumento, o protótipo e os principais resultados dos testes de sua operação, as perspectivas futuras e a ciência a ser desenvolvida com o instrumento nas fases II e III. Neste trabalho é dada ênfase ao desenvolvimento, testes de operação e principais resultados do protótipo. É discutida brevemente a ciência que pode ser feita com o instrumento. Tanto os detalhes técnicos quanto os principais parâmetros estimados para o instrumento nas próximas fases de desenvolvimento e o desempenho do protótipo serão publicados em breve.

  10. Avaliação de genótipos de Leucaena spp. nas condições edafoclimáticas de São Carlos,SP: II. determinações bromatológicas no período de estabelecimento Evaluation of Leucaena spp. genotypes in the edaphic and climatic conditions of São Carlos, SP: II. bromatological determinations at the establishment period

    Directory of Open Access Journals (Sweden)

    A.C.P. de A. Primavesi

    1994-04-01

    Full Text Available Em experimento conduzido em Latossolo Vermelho-Amarelo distrófico, em área da EMBRAPA - CPPSE em São Carlos, situada a 22°01'S e 47°53'W, com altitude de 856 m e média de precipitação anual de 1502 mm, procedeu-se a determinação da composição bromatológicade folhas, hastes com diâmetro menor que 6 mm e vagens, de genótipos de leucena. Os genótipos avaliados, foram: L.leucocephala cv. Texas 1074 (TI, L.leucocephala 29 A9 (T2, L.leucocephala 11 x L.dlversifolia 25 (T3, L.leucocephala 11 x L.diversifolia 26 (T4, L.leucocephala 24-19/2-39 x L.diverstfolia 26 (T5 e L.leucocephala c v. Cunningham (testemunha. Verificou-se que: os genótipos avahados não apresentaram diferenças nas determinações bromatológicas, realizadas nas folhas e talos finos; o genótipo T3 registrou o maior teor de proteína bruta (28,06%, de fósforo (0,29% e a maior relação PB/FDN e o menor teor de FDN para vagens; os genótipos apresentaram os seguintes teores médios, em porcentagem, para a composição bromatológicadas folhas, vagens e talos finos, respectivamente: Proteína bruta (18,57; 21,68; 6,41; Fibra detergente neutro (29,09; 41,58; 71,01; Fósforo (0,12; 0,22; 0,06; Cálcio (1,39; 0,36; 0,49; Magnesio (0,51; 0,28; 0,24; Tanino (1,32; 1,15; 0,28 e Digestibilidade "in vitro" (58,39; 61,22; 33,61; os teores de proteína e fósforo apresentaram a seguinte ordem decrescente nas partes das plantas: vagens > folhas > talos finos; os teores de cálcio: folhas > talos finos > vagens e de magnésio: folhas > vagens > talos finos.In a trial conducted on a distrofic Red-Yellow Latossol, at EMBRAPA-CPPSE, São Carlos, located at 22°01'S and 47'53'W, altitude of 856 m and with a mean annual rainfall of 1502 mm, the bromatological composition of leaves, stems smaller than 6 mm diameter and pods of leucena genotypes was determined. The genotypes evaluated were: L.leucocephala cv. Texas 1074 (T1, L.leucocephala 29 A9 (T2, L.leucocephala 11 x L.dlversifolia 25

  11. History of diabetes mellitus.

    Science.gov (United States)

    Ahmed, Awad M

    2002-04-01

    Clinical features similar to diabetes mellitus were described 3000 years ago by the ancient Egyptians. The term "diabetes" was first coined by Araetus of Cappodocia (81-133AD). Later, the word mellitus (honey sweet) was added by Thomas Willis (Britain) in 1675 after rediscovering the sweetness of urine and blood of patients (first noticed by the ancient Indians). It was only in 1776 that Dobson (Britain) firstly confirmed the presence of excess sugar in urine and blood as a cause of their sweetness. In modern time, the history of diabetes coincided with the emergence of experimental medicine. An important milestone in the history of diabetes is the establishment of the role of the liver in glycogenesis, and the concept that diabetes is due to excess glucose production Claude Bernard (France) in 1857. The role of the pancreas in pathogenesis of diabetes was discovered by Mering and Minkowski (Austria) 1889. Later, this discovery constituted the basis of insulin isolation and clinical use by Banting and Best (Canada) in 1921. Trials to prepare an orally administrated hypoglycemic agent ended successfully by first marketing of tolbutamide and carbutamide in 1955. This report will also discuss the history of dietary management and acute and chronic complications of diabetes.

  12. Case 22:Type II diabetes

    Science.gov (United States)

    Diabetes mellitus is characterized by elevated blood glucose levels. It is composed of two types depending on the pathogenesis. Type I diabetes is characterized by insulin deficiency and usually has its onset during childhood or teenage years. This is also called ketosis-prone diabetes. Type II diab...

  13. Intervención educativa en adultos mayores con diabetes mellitus en Guatemala

    Directory of Open Access Journals (Sweden)

    José Manuel Contreras Tejeda

    2014-08-01

    Full Text Available Se realizó un estudio de intervención comunitaria, con el objetivo de incrementar los conocimientos en pacientes diabéticos adultos mayores, pertenecientes al Departamento Alta Verapaz, Cobán, Guatemala; en el período comprendido desde junio de 2011 hasta junio de 2012. El universo de estudio estuvo constituido por los pacientes diabéticos dispensarizados por el médico y la enfermera en el área periférica, conformándose la muestra con 46 de ellos, a los cuales se les evaluó el grado de conocimientos previo y posterior a la aplicación de la intervención para modificar estilos de vida, empleando para ello técnicas participativas. Para obtener la información se revisaron las historias clínicas individuales, se realizaron entrevistas y se aplicaron cuestionarios a los pacientes, antes y después de aplicadas las técnicas educativas. Los resultados fueron procesados por métodos estadísticos. En la muestra predominaron los pacientes con diabetes mellitus tipo II. Después de la intervención hubo un incremento en las respuestas correctas en un 63.04%, haciéndose más marcado a medida que aumenta el nivel de escolaridad y en los que tienen más de diez años de evolución de la enfermedad. El estado nutricional se mejoró en un 50%. Se logró un mejor control de las complicaciones crónicas, así como del control metabólico en un 78.26%. Las charlas educativas en la comunidad resultaron efectivas para la incorporación de elementos educativos que incidieron en el mejor autocuidado de los pacientes diabéticos

  14. Autopsia verbal en hombres adultos con diabetes tipo 2: estudio cualitativo

    Directory of Open Access Journals (Sweden)

    Geu Mendoza-Catalán

    2017-09-01

    Full Text Available Introducción: La diabetes mellitus tipo 2 (DMT2 es un padecimiento crónico cuya incidencia se incrementa en forma alarmante. El objetivo fue identificar los factores asociados al no autocuidado en hombres con muerte prematura y diagnóstico de DMT2. Materiales y Métodos: Se realizaron seis entrevistas cualitativas a familiares de hombres con DMT2 que fallecieron por complicaciones de su enfermedad, utilizando la metodología de la autopsia verbal. Los resultados se analizaron mediante el análisis de contenido. Resultados: Dentro de los factores que surgieron como limitantes para el autocuidado fueron: la negación de la DMT2, el trabajo, el machismo, preferencia en los alimentos, apoyo familiar, el consumo de alcohol, el consumo de tabaco y la depresión. Discusión: Los hombres con DMT2 se ven influenciados por diversas circunstancias que limitan cuidarse, atenderse y por consiguiente presentar desventajas de salud, complicaciones e incluso una muerte temprana. Conclusiones: Desde la perspectiva de enfermería los resultados ayudan a comprender el comportamiento de los hombres ante esta enfermedad en donde se requiere cuidado constante, a la par que una conciencia legítima de que no se deja de ser hombre por cuidarse.  Cómo citar este artículo: Mendoza-Catalán G, Gallegos-Cabriales EC, Figueroa-Perea JG. Autopsia verbal en hombres adultos con diabetes tipo 2: estudio cualitativo. Rev Cuid. 2017; 8(3: 1786-98. http://dx.doi.org/10.15649/cuidarte.v8i3.420

  15. Alteraciones de la hemostasia en la diabetes mellitus Alterations of hemostasis in the diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Patricia Caunedo Almagro

    2005-04-01

    Full Text Available La diabetes mellitus (DM se clasifica en 2 tipos de acuerdo con su patogénesis: la tipo 1 representa menos del 10 % del total de pacientes, la DM tipo 2 es más común dentro de la población de pacientes diabéticos. Se han encontrado múltiples alteraciones de la hemostasia en los pacientes con este padecimiento. Estudios realizados en plaquetas, coagulación sanguínea y fibrinólisis han permitido asegurar que estos trastornos son posiblemente un factor importante en el estado pretrombótico que presentan estos enfermos. Las investigaciones en las plaquetas han demostrado una hiperreactividad plaquetaria, un aumento de la actividad procoagulante de las plaquetas. Por otra parte, la mayoría de los autores coinciden en la actualidad en que la DM es un estado de hipercoagulabilidad,lo cual se basa en numerosas investigaciones sobre la enfermedad y el mecanismo de la coagulación que demuestran el aumento del fibrinógeno, factor VII y factor von Willebrand, así como de los marcadores de activación de este sistema. Además, se han demostrado alteraciones en el sistema fibrinolítico, como el aumento del inhibidor del activador del plasminógeno y del inhibidor de la fibrinólisis activado por trombina. En este trabajo se presentan algunos mecanismos que pudieran explicar las alteraciones en la hemostasia que posiblemente contribuyan al desarrollo de complicaciones trombóticas que se presentan en estos pacientes.Diabetes mellitus is classified into 2 types according to its pathogenesis: type 1 accounts for less than 10 % of the total of patients, whereas type 2 is the most common in the population of diabetic patients. Multiple alterations of hemostasis have been found among the patients suffering from this disease. The studies conducted in platelets, blood coagulation and fibrinolysis have allowed to assert that these disorders are probably an important factor in the prethrombotic state of these patients. The investigations carried out with

  16. Alterações pulmonares em um modelo de diabetes mellitus em ratos: o efeito da terapia antioxidante Lung alterations in a rat model of diabetes mellitus: effects of antioxidant therapy

    Directory of Open Access Journals (Sweden)

    Luiz Alberto Forgiarini Junior

    2010-10-01

    Full Text Available OBJETIVO: Avaliar as alterações estruturais no pulmão de ratos com diabetes mellitus (DM através da quantificação do estresse oxidativo e do dano ao DNA, assim como determinar os efeitos de superóxido dismutase (SOD exógena nessas alterações. MÉTODOS: Estudo experimental controlado com 40 ratos Wistar, divididos em quatro grupos (10 animais cada: grupo controle, grupo SOD (sem DM e tratados com SOD, grupo DM (com DM induzido por estreptozotocina, e grupo DM+SOD (com DM induzido por estreptozotocina e tratados com SOD. Os animais foram avaliados por um período de 60 dias, iniciado a partir do dia em que os animais com diabetes induzido por estreptozotocina apresentaram glicemia > 250 mg/dL. Nos últimos 7 dias do período, os animais nos grupos tratados receberam SOD. Ao final do tempo de estudo, amostras de tecido pulmonar foram coletadas para análise histopatológica e avaliação do estresse oxidativo e do dano ao DNA. RESULTADOS: Não houve diferenças significativas entre os grupos em relação ao dano ao DNA. Houve um aumento significativo na matriz extracelular e hiperplasia do endotélio capilar no grupo DM quando comparado com os grupos controle e SOD. Também houve mudanças significativas em pneumócitos tipo II e macrófagos intravasculares, sugerindo um processo inflamatório no grupo DM. Entretanto, uma redução na matriz extracelular, endotélio capilar normal e pneumócitos tipo II normais foram encontrados no grupo com DM+SOD. CONCLUSÕES: A administração exógena de SOD pode reverter alterações nos pulmões de animais com DM induzido.OBJECTIVE: To evaluate structural alterations of the lung in rats with diabetes mellitus (DM, by quantifying oxidative stress and DNA damage, as well as to determine the effects that exogenous superoxide dismutase (SOD has on such alterations. METHODS: A controlled experimental study involving 40 male Wistar rats, divided into four groups (10 animals each: control; SOD

  17. Um olhar sobre o diabetes na infância e na juventude: nem todos são Tipo 1

    Directory of Open Access Journals (Sweden)

    Mauren Isfer ANGHEBEM-OLIVEIRA

    2013-12-01

    Full Text Available O Diabetes mellitus (DM é caracterizado por um quadro de hiperglicemia crônica, que com os anos pode causar disfunção endotelial e sérias complicações vasculares, como a retinopatia, nefropatia e o infarto agudo do miocárdio. À medida que a ciência avança na compreensão da fisiopatologia e das características clínico-laboratoriais do diabetes, sua classificação tem sido adaptada, justamente porque a correta classificação do diabetes impacta no prognóstico e tratamento do paciente. Atualmente, o diabetes é classificado em DM tipo 1, DM tipo 2, DM gestacional e Outros Tipos Específicos, que inclui a categoria MODY (do inglês, Maturity Onset Diabetes of the Young ou diabetes da maturidade com início na juventude. O que esta revisão pretende mostrar é quem nem todo diabetes diagnosticado na infância e na juventude é DM tipo 1. O correto diagnóstico e classificação do DM são fundamentais, uma vez que o prognóstico e o tratamento podem diferir dependendo da causa que predispôs a criança ou adolescente à doença.

  18. Suplementação oral com picolinato de cromo em pacientes com diabetes tipo 2: um ensaio clínico randomizado

    OpenAIRE

    Paiva, Ana Nunes

    2015-01-01

    Diante da importância do papel do cromo no mecanismo da sensibilidade à insulina tem sido estudada a suplementação com este mineral em pacientes diabéticos. Assim, o objetivo deste estudo foi avaliar o efeito da suplementação oral com picolinato de cromo (PicCr) nas concentrações glicêmicas, lipidêmicas, perfil antioxidante e parâmetros antropométricos em pacientes com diabetes mellitus tipo 2 (DM2) mal controlados(hemoglobina glicada A1c (HbA1c) ≥ 7%). Para tanto, foi conduzido um ensaio clí...

  19. Coste-efectividad de la adición de acarbosa al tratamiento de pacientes con diabetes tipo 2 en España

    OpenAIRE

    Piñol, Carme; Roze, Stephane; Valentine, William; Evers, Thomas

    2007-01-01

    Objetivos: Evaluar el coste-efectividad de la adición de acarbosa al tratamiento de pacientes con diabetes mellitus tipo 2 (DM2) en España. Métodos: Se utilizó el CORE Diabetes Model (modelo de simulación informática publicado y validado) para proyectar a largo plazo los resultados clínicos y de costes de la DM2. Las probabilidades de transición y los riesgos se obtuvieron de distintas publicaciones. Los efectos del tratamiento y las características basales de la cohorte se obtuvieron de un m...

  20. A influência da prática de exercício físico regular no idoso diabético tipo 2

    OpenAIRE

    Gonçalves, Mariana de Aguiar

    2012-01-01

    Trabalho final de mestrado integrado em Medicina área cientifica de Medicina, apresentado á Faculdade de Medicina da Universidade de Coimbra Introdução: A Diabetes Mellitus tipo 2 é uma doença crónica, cuja prevalência está intimamente ligada ao envelhecimento populacional. Apresenta-se como a epidemia do século XXI, representando um dos mais sérios problemas a nível de saúde pública. O aumento do número de casos na Sociedade Portuguesa requer a adopção de estratégias que possam ...

  1. Método predictivo de volatilidad tipo cambio

    Directory of Open Access Journals (Sweden)

    Jeffrey Viales Abellán

    2011-01-01

    Full Text Available Las series temporales descritas por precios de ciertos activos financieros tales como el de las acciones y divisas presentan dos principales características, excesos de kurtosis y clustering de volatilidad. Para recoger estas características se han utilizado modelos no lineales tales como los modelos Garch o Volatilidad Condicionada y los modelos de Volatilidad Estocástica, ambos tipos de modelo son empleados para la gestión del riesgo cambiario a corto plazo; el primer tipo de modelos definen la volatilidad en función de la misma volatilidad rezagada y de los shocks (innovaciones de volatilidad; el segundo tipo de modelos son similares a los modelos Garch con la variante de que la volatilidad incluye por si misma un término aleatorio de tipo proceso Wienner2; estos modelos son empleados para simular caminatas aleatorias del tipo de cambio con volatilidades simuladas por las ecuación estocásticas de volatilidad.En el presente trabajo se analizará el desempeño del modelo Garch en comparación a las medidas de volatilidad utilizadas actualmente para la gestión del riesgo cambiario; sus implicaciones para la gestión de riesgos.

  2. Radiation retinopathy in diabetes mellitus

    International Nuclear Information System (INIS)

    Dhir, S.P.; Joshi, A.V.; Banerjee, A.K.

    1982-01-01

    A case of radiation retinopathy in a diabetic individual who received a total dose of 45 Gy for lymphoblastic lymphoma of the orbit is reported. The relationship between radiation retinopathy and diabetes mellitus is discussed. (Auth.)

  3. Disturbances of Haemostasis in Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Mohamed A. Fattah

    2004-01-01

    Full Text Available Diabetes mellitus is associated with disturbances in haemostasis that could contribute to the development of thrombotic complications.The present study was undertaken to determine the behavior of coagulation variables and fibrinolytic system in diabetes mellitus. Forty five diabetic patients and forty five matched controls were evaluated by doing the following haemostatic parameter, prothrombin time, partial thromboplastin time, thrombin time, coagulation factors assay II, VII, IX, & plasma fibrinogen, ADP-induced platelet aggregation, protein C, a2- antiplasmin, PAI and FDPs. Generally diabetic patients have high levels of fibrinogen, a2- antiplasmin, & PAI and lower level of protein C. Other haemostatic parameters did not show statistically significant difference between diabetic patients and control group. Significantally elevated levels of PAI, a2- antiplasmin together with low protein C level in diabetic patients may result in the disturbance of haemostatic balance favoring thrombotic events. Conclusion: High levels of plasma fibrinogen, a2A- antiplasmin with low plasma protein C activity could lead to a prothrombotic tendency in insulin dependent diabetic patients. Moreover, in non-insulin dependent diabetic patients, the above mentioned parameters together with high levels of ADP-induced platelet aggregation and plasminogen activator inhibitor may increase the risk of thrombotic complications. Obesity can be considered as an additional risk factor for development of thrombosis in diabetic patients.

  4. Diabetes Mellitus and the Musculoskeletal System

    International Nuclear Information System (INIS)

    Monu, Johnny V.J.

    2015-01-01

    Diabetes mellitus is a metabolic disease with systemic manifestations. Occurrence is increasing worldwide from 153m to 347m from 1980 to 2011. Traditionally there are two main types: Insulin dependent or juvenile diabetes and non-insulin dependent or Maturity onset or insulin resistant diabetes. Gestational diabetes the second type of diabetes is increasingly seen in young patients and it evolves into insulin dependence. Obesity is causally related to type II diabetes. Diabetes Mellitus affects appendicular and peripheral structures more commonly – ankle and feet. Diabetes in the MSK System effects manifested as congenital problems, Peripheral neuropathy, Peripheral vasculopathy Infections and Connective tissue changes. The disease target Structures like Cardio-vascular system, Central nervous system (brain, eyes) and peripheral nerves, Reticulo-endothelial system, Kidneys and Musculoskeletal system. Osteomyelitis fractures including fragmentation of bones and disorganization of joints – neuropathic changes. Diabetic Myopathy occurs predominantly in long-standing, poorly controlled type 1 diabetics often have other vascular or end organ complications. Etiology related to microvascular disease leads to muscle ischemia and infarction eventual muscle atrophy

  5. Plasma Renin Activity in Diabetes Mellitus

    International Nuclear Information System (INIS)

    Pyo, Heui Jung; Park Jung Sik; Kim, Sung Kwon; Choi, Kang Won; Lee, Jung Sang; Lee, Mun Ho

    1979-01-01

    To evaluate the renin-angiotensin-aldosterone system in diabetes mellitus, basal plasma renin activity (PRA) and its response to intravenous furosemide were determined in 40 diabetic subjects. The diabetics were divided into 4 groups according to the presence of nephropathy and/or hypertension. Uncomplicated diabetics (Group I) were taken as control group and the results of the other groups were compared to this group. In diabetics with nephropathy alone (Group II), and with nephropathy and hypertension (Group III), basal PRA values were 0.63±0.59 ng/ml/hr., and 0.79±0.62 ng/ml/hr., respectively, both significantly lower than control group. (1.53±1.09 ng/ml/hr.). (p<0.05) In both of the above groups, the responses to intravenous furosemide tended to be blunted. On the other hand, in diabetics, with hypertension only (Group IV), the basal and stimulated PRA were not significantly different from control. Above results suggests that nephropathy may be one of the factors which suppress renin activity in diabetes mellitus

  6. Plasma Renin Activity in Diabetes Mellitus

    Energy Technology Data Exchange (ETDEWEB)

    Pyo, Heui Jung; Sik, Park Jung; Kim, Sung Kwon; Choi, Kang Won; Lee, Jung Sang; Lee, Mun Ho [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1979-03-15

    To evaluate the renin-angiotensin-aldosterone system in diabetes mellitus, basal plasma renin activity (PRA) and its response to intravenous furosemide were determined in 40 diabetic subjects. The diabetics were divided into 4 groups according to the presence of nephropathy and/or hypertension. Uncomplicated diabetics (Group I) were taken as control group and the results of the other groups were compared to this group. In diabetics with nephropathy alone (Group II), and with nephropathy and hypertension (Group III), basal PRA values were 0.63+-0.59 ng/ml/hr., and 0.79+-0.62 ng/ml/hr., respectively, both significantly lower than control group. (1.53+-1.09 ng/ml/hr.). (p<0.05) In both of the above groups, the responses to intravenous furosemide tended to be blunted. On the other hand, in diabetics, with hypertension only (Group IV), the basal and stimulated PRA were not significantly different from control. Above results suggests that nephropathy may be one of the factors which suppress renin activity in diabetes mellitus

  7. General aspects of diabetes mellitus.

    Science.gov (United States)

    Alam, Uazman; Asghar, Omar; Azmi, Shazli; Malik, Rayaz A

    2014-01-01

    Diabetes mellitus is a heterogeneous group of disorders characterized by hyperglycemia due to an absolute or relative deficit in insulin production or action. The chronic hyperglycemia of diabetes mellitus is associated with end organ damage, dysfunction, and failure, including the retina, kidney, nervous system, heart, and blood vessels. The International Diabetes Federation (IDF) estimated an overall prevalence of diabetes mellitus to be 366 million in 2011, and predicted a rise to 552 million by 2030. The treatment of diabetes mellitus is determined by the etiopathology and is most commonly subdivided in type 1 and type 2 diabetes mellitus. There is a greater propensity towards hyperglycemia in individuals with coexisting genetic predisposition or concomitant drug therapy such as corticosteroids. The screening for diabetes mellitus may either be in the form of a 2hour oral glucose tolerance test, or via HbA1c testing, as recently recommended by the American Diabetes Association (ADA). Strong associations have been shown in observational studies suggesting poor clinical outcomes both with chronic hyperglycemia and acutely in intensive care settings. However, tight glycemic control in this setting is a contentious issue with an increased incidence of hypoglycemia and possible increase in morbidity and mortality. In a critically ill patient a glucose range of 140-180mg/dL (7.8-10.0mmol/L) should be maintained via continuous intravenous insulin infusion.

  8. Electrodiagnostic evaluation of median nerve conduction in Type II ...

    African Journals Online (AJOL)

    MJP

    2015-12-29

    Dec 29, 2015 ... Type II diabetes mellitus patients that were asymptomatic for peripheral neuropathy: a case control study. Owolabi LF 1*, Adebisi S2, ... degree of abnormality and monitoring the clinical course of the disease. Symptoms of DN ...

  9. La Planta única como tipo resistente a la escala

    OpenAIRE

    Colmenares Vilata, Silvia

    2014-01-01

    El sistema capitalista ha generado dos de los modelos espaciales de indiferencia funcional más extremos: por un lado, el espacio tecnificado y repetido del edificio de oficinas en altura, encarnado por la ?planta tipo? y, por otro, el espacio diáfano y extenso del gran contendor, que responde a la lógica de lo que llamaremos ?planta única?. En los edificios construidos para la industria automovilística y bélica americana se encuentra el germen de un tipo que servirá de modelo para los nuevos ...

  10. Mercado financiero y crédito del soberano en el tránsito de Carlos V a Felipe II. La intervención en los tipos de cambio mediante las pragmáticas del 1551-1557

    Directory of Open Access Journals (Sweden)

    Carlos Javier de CARLOS MORALES

    2009-12-01

    Full Text Available RESUMEN: Durante la primera mitad del siglo XVI hubo una considerable expansión de las actividades financieras. La Hacienda Real de Castilla se estuvo apoyando en los cauces de adelanto y transferencia de dinero desarrollados al socaire del auge mercantil, pero correlativamente generó un aumento de los costes financieros que estuvo relacionado, en parte, con la aparición de fenómenos especulativos. En los años centrales de la centuria tanto Carlos V como Felipe II entendieron que, con el fin de enderezar el déficit, convenía atajar los intereses excesivos que conllevaban los cambios. De esta manera fueron promulgando las pragmáticas de 1551-1552, 1555 y 1557, cuyos efectos pudieron ser contradictorios con los objetivos que perseguían.ABSTRACT: During the first half of the sixteenth century there was a substantial growth in financial activities. The Castilian Royal treasury was based on loans and credit transfers protected by the commercial growth. However, it provoked a rise in financial costs, which was partly related to the new speculation. By the middle of the century both Charles V and Philip II understood that in order to get the deficit back on course, it was necessary to stop the excessive interests caused by these changes. This way, they enacted the new laws in 1551-1552,1555 and 1557, whose effects could have been contradictory towards the desired aims.

  11. Diabetes mellitus in elderly

    Directory of Open Access Journals (Sweden)

    Farida Chentli

    2015-01-01

    Full Text Available Diabetes mellitus (DM frequency is a growing problem worldwide, because of long life expectancy and life style modifications. In old age (≥60–65 years old, DM is becoming an alarming public health problem in developed and even in developing countries as for some authors one from two old persons are diabetic or prediabetic and for others 8 from 10 old persons have some dysglycemia. DM complications and co-morbidities are more frequent in old diabetics compared to their young counterparts. The most frequent are cardiovascular diseases due to old age and to precocious atherosclerosis specific to DM and the most bothersome are visual and cognitive impairments, especially Alzheimer disease and other kind of dementia. Alzheimer disease seems to share the same risk factors as DM, which means insulin resistance due to lack of physical activity and eating disorders. Visual and physical handicaps, depression, and memory troubles are a barrier to care for DM treatment. For this, old diabetics are now classified into two main categories as fit and independent old people able to take any available medication, exactly as their young or middle age counterparts, and fragile or frail persons for whom physical activity, healthy diet, and medical treatment should be individualized according to the presence or lack of cognitive impairment and other co-morbidities. In the last category, the fundamental rule is "go slowly and individualize" to avoid interaction with poly medicated elder persons and fatal iatrogenic hypoglycemias in those treated with sulfonylureas or insulin.

  12. Alcoholism and Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Soo-Jeong Kim

    2012-04-01

    Full Text Available Chronic use of alcohol is considered to be a potential risk factor for the incidence of type 2 diabetes mellitus (T2DM, which causes insulin resistance and pancreatic β-cell dysfunction that is a prerequisite for the development of diabetes. However, alcohol consumption in diabetes has been controversial and more detailed information on the diabetogenic impact of alcohol seems warranted. Diabetes, especially T2DM, causes dysregulation of various metabolic processes, which includes a defect in the insulin-mediated glucose function of adipocytes, and an impaired insulin action in the liver. In addition, neurobiological profiles of alcoholism are linked to the effects of a disruption of glucose homeostasis and of insulin resistance, which are affected by altered appetite that regulates the peptides and neurotrophic factors. Since conditions, which precede the onset of diabetes that are associated with alcoholism is one of the crucial public problems, researches in efforts to prevent and treat diabetes with alcohol dependence, receives special clinical interest. Therefore, the purpose of this mini-review is to provide the recent progress and current theories in the interplay between alcoholism and diabetes. Further, the purpose of this study also includes summarizing the pathophysiological mechanisms in the neurobiology of alcoholism.

  13. Tipos de pasteurização e agentes coagulantes na fabricação do queijo tipo prato

    OpenAIRE

    Ramos, Thaís de Melo

    2013-01-01

    O presente trabalho foi realizado com os objetivos de avaliar a influência do tipo de pasteurização pelos sistemas de aquecimento indireto high temperature short time, ou HTST, e injeção direta de vapor (IDV), e avaliar a influência de duas diferentes enzimas coagulantes na fabricação do queijo tipo prato. O delineamento experimental utilizado neste experimento foi um fatorial 2 x 2 x 5 inteiramente casualizado, sendo dois sistemas de pasteurização (HTST e IDV), duas enzimas coagulantes e cin...

  14. DERMATOGLYPHIC PATTERNS IN TYPE 2 DIABETES MELLITUS

    African Journals Online (AJOL)

    2018-02-28

    Feb 28, 2018 ... COMMENTARY. DERMATOGLYPHIC PATTERNS IN TYPE 2 DIABETES. MELLITUS ... contributions in diabetes mellitus and in various medical disorders. Hence dermatoglyphic .... female cases. These findings are similar to ...

  15. EPIDEMIOLOGICAL STUDY OF DIABETIC RETINOPATHY IN DIABETES MELLITUS PATIENTS IN TERTIARY CARE CENTRE

    Directory of Open Access Journals (Sweden)

    Bhaskar

    2016-02-01

    Full Text Available OBJECTIVE The study objective was to examine the effect of glycaemic control and variations on the incidence and progression of diabetic retinopathy (DR among the diabetes mellitus patients visiting Medicine and Ophthalmology OPD Sapthagiri Medical college, Bangalore. MATERIALS AND METHODS 10 patients with type 1 diabetes mellitus, and 70 persons with type 2 diabetes mellitus, visiting the Medicine OPD of Sapthagiri Medical College and referred to Ophthalmology department of the above to detect the Diabetic Retinopathy changes in a diabetes mellitus management programme conducted for 3 months in Bangalore, participated in the study. Patients who were followed up for 6 months the same above were also included in the study. Analyses were conducted to assess the relationship between the risk factors, incidence and progression of Diabetic Retinopathy among Diabetes Mellitus patients and management. MAIN OUTCOME MEASURES To determine the risk factors associated with it, stage of retinopathy diagnosed at presentation, management of it, and final visual outcome. The prevention is by strict glycaemic control, prompt use of anti-diabetic drugs and regular exercises. These included age and gender-adjusted prevalence of diabetes and diabetic retinopathy, 1 and correlation of prevalence with history-based risk factors. RESULTS The three months cumulative incidence of DR was 58 %in type I diabetes mellitus and 42 % among type II Diabetes mellitus. After controlling for known risk factors for DR,1 a high baseline haemoglobin A1c (HbA1c, ethnicity, age, type of diabetes mellitus, duration were associated with the incidence of referable DR in patients with type 1 and type 2 diabetes mellitus. The age- and gender-adjusted prevalence rate of diabetes in urban Bangalore 28.2% (95% confidence interval [CI], and the prevalence of diabetic retinopathy in general population was 3.5% (95% CI. The prevalence of diabetic retinopathy in the population with diabetes

  16. Neurofibromatosis tipo 2: La historia de Lidia Neurofibromatosis type 2: Life story of Lidia

    Directory of Open Access Journals (Sweden)

    Ares Solanes

    2012-06-01

    Full Text Available La Neurofibromatosis tipo 2 (NF2 es una enfermedad minoritaria hereditaria caracterizada por la presentación progresiva de múltiples tumores, especialmente Schwanomas Vestibulares Bilaterales, a partir de la segunda década de vida. Su tratamiento con cirugía o radioterapia no evita la pérdida de audición. El pronóstico es complicado y los pacientes deben enfrentarse al progresivo deterioro de su calidad de vida. Un estudio cualitativo a través de la historia de vida de nuestra informante clave nos permite explorar y comprender su vivencia, afecta de Neurofibromatosis tipo II (NF2, así como conocer sus necesidades y aprender de sus recursos adaptativos.Neurofibromatosis type 2 (NF2 is a minority hereditary disease characterized by the development of multiple tumours, especially bilateral vestibular schwannomas, in young adults. Treatments with surgery or radiotherapy are performed to delay hearing loss. The prognosis is complicated and patients face the deterioration of their quality of life. A qualitative study through our key subject's life allows us to explore and understand her experience, as a NF2 sufferer, to identify her needs and to learn about her adaptive measures.

  17. Osteoporosis and diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Andrea Montagnani

    2013-03-01

    Full Text Available Introduction: Diabetes mellitus (DM and osteoporotic fractures are major causes of mortality and morbidity in older subjects. Recent reports have revealed close association between fracture risk and DM types 1 and 2 (DM1 and DM2, respectively. Aim of this review is to highlight the importance of these diseases in the elderly and examine certain etiopathogenetic aspects of DM associated osteoporosis, which could be useful in management of diabetic patients. Materials and methods: We searched the Embase and PubMed databases using diabetes, osteoporosis, and bone mineral density (BMD as search terms and 1989-2009 as publication dates. Discussion: The risk of fractures seems to be increased in both types of DM although DM2 seems to be associated with normal-high BMDs compared with the normal population. This apparent paradox could reflect greater bone frailty in diabetic patients that are unrelated to adipose tissue, hyperinsulinemia, deposition of advanced glycosylation end products in collagen, reduced serum IGF-1 levels, hypercalciuria, renal failure, microangiopathy, and/or inflammation. Diabetic patients’ propensity to fall and multiple comorbidities might also explain their higher fracture rates. The effects of drugs that inhibit bone resorption in diabetic patients are probably similar to those obtained in nondiabetics although there is little information on this issue. In general, effective treatment of diabetes has positive effects on bone metabolism. Metformin acts directly on bone tissue, reducing AGE accumulation, and insulin has direct effects on osteoclast activity. In contrast, the thiazolidinediones seem to have negative effects since they orient mesenchymal progenitor cell differentiation toward adipose rather than bone tissue. Incretin therapy is a newer approach that appears to modify interactions between nutrition and bone turnover (e.g., postprandial suppression of bone resorption. Conclusions: Better understanding of how

  18. Diabetes insipidus: main aspects and comparative analysis with diabetes mellitus Diabetes insipidus: principais aspectos e análise comparativa com diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Flávia Lúcia Abreu Rabelo

    2009-01-01

    Full Text Available Diabetes mellitus is a disease characterized by the excess of sugar in the blood and urine. The two most common types of diabetes are insulin-dependent diabetes mellitus and insulin-resistant diabetes mellitus, both presenting glycemic regulation-damage caused by insulin. Nevertheless, there is another type of diabetes that is less known but not less important, the diabetes insipidus, which is characterized by a problem with the synthesis, secretion or action of the ADH (anti-diuretic hormone that can result in polyuric syndromes with increased excretion of hypotonic urine. Physiologically, variations in the osmotic pressure activate osmoceptors that stimulate the ADH secretion, increasing water reabsorption in the kidney collection tubes. This article intends to revise a wide-ranging study on diabetes insipidus, aiming at a comparative analysis of the incidence, diagnosis, causes, types, treatment and consequences between diabetes insidipus and diabetes mellitus. Diabetes mellitus and insipidus are two different pathologies with a single similarity that is the diabetes itself, that is, the polyuria established. The knowledge of the significant differences between the pathologies studied is important once diabetes insipidus is less known, but can lead to serious complications if not properly treated. O diabetes mellitus é uma doença caracterizada pelo excesso de açúcar no sangue e na urina. Os dois tipos mais comuns de diabetes são diabetes mellitus insulino-dependente e diabetes mellitus insulino – resistente, e que ambos apresentam comprometimento da regulação da glicemia por ação da insulina. No entanto, existe outra forma de diabetes menos conhecida, mas não menos importante, o diabetes insipidus, que é caracterizado por um distúrbio na síntese, secreção ou ação do ADH (hormônio antidiurético, que pode resultar em síndromes poliúricas com excreção aumentada de urina hipotônica. Fisiologicamente, variações na press

  19. CARACTERIZAÇÃO PÓS-COLHEITA E SENSORIAL DE GENÓTIPOS DE BANANEIRAS TIPO PRATA

    Directory of Open Access Journals (Sweden)

    ARIANE CASTRICINI

    2015-03-01

    Full Text Available RESUMO O norte de Minas Gerais é grande produtor de banana ‘Prata-Anã’ irrigada, cultura altamente suscetível ao Mal-do-Panamá. O uso de genótipos resistentes é uma alternativa, mas os frutos devem apresentar características pós-colheita o mais próximo possível da ‘Prata-Anã’, para melhor aceitação pelos consumidores. O objetivo do trabalho foi caracterizar frutos em pós-colheita, identificar a preferência e a intenção de compra de diferentes genótipos de bananeira tipo Prata. Os genótipos Prata-Anã, BRS Platina e Fhia-18. foram caracterizados no ponto de colheita (verdes e maduros (estádio seis de maturação, por avaliações químicas, físicas e sensoriais. Quando verde, ‘BRS Platina’ apresentou maior massa fresca e tamanho que ‘Fhia-18’ e ‘Prata-Anã’. ‘Fhia-18.’ teve a tonalidade verde da casca mais intensa que a dos demais genótipos. Madura, ‘BRS Platina’ foi mais firme, mas com a mesma resistência ao despencamento que ‘Fhia-18’ e superior à ‘Prata-Anã’. ‘Fhia-18’ apresentou cor da casca com amarelo mais clara e tão brilhante quanto da ‘Prata-Anã’, mas ‘BRS Platina’ teve a tonalidade de amarelo mais intensa. Bananas ‘Fhia-18’ foram mais ácidas, ‘BRS Platina’, com menor acidez titulável, e ‘Prata-Anã’, o maior teor de sólidos solúveis. Os genótipos Prata-Anã e BRS Platina tiveram maior preferência e intenção de compra pelos consumidores, sendo as bananas ‘Prata-Anã’ em dedos e ‘BRS Platina’ e ‘Fhia-18’ em dedos, buquê e penca, as mais preferidas. Entretanto, a maioria compraria bananas ‘Prata-Anã’ em buquê e ‘BRS Platina’ e ‘Fhia-18’ em penca. Enquanto verdes, os genótipos foram semelhantes à ‘Prata-Anã’, e maiores diferenças químicas e físicas ocorreram quando maduros.

  20. Parâmetros de desempenho e carcaça de genótipos de frangos tipo caipira

    Directory of Open Access Journals (Sweden)

    R.C. Veloso

    2014-08-01

    Full Text Available Objetivou-se com este trabalho avaliar as características de desempenho e de carcaça de sete genótipos de frangos tipo caipira da linhagem Redbro. Foram utilizados 840 pintos de um dia, machos, distribuídos em delineamento inteiramente ao acaso, dos seguintes genótipos: Caboclo, Carijó, Colorpak, Gigante Negro, Pesadão Vermelho, Pescoço Pelado e Tricolor. Os frangos foram alojados em 28 boxes, sendo 30 frangos por boxe, em galpão de alvenaria com acesso a um piquete de 45m², em quatro repetições. As características de desempenho (conversão alimentar, ganho em peso médio diário, consumo de ração médio diário foram avaliadas nos períodos: um a 28, um a 56, um a 70 e um a 84 dias de idade. O peso corporal foi avaliado aos 28, 56, 70 e 84 dias de idade. As características de carcaça (peso e rendimento de carcaça, peito e pernas foram obtidas a partir do abate de dois frangos por boxe, aos 85 dias de idade. As análises estatísticas foram realizadas utilizando-se o "proc glm" do SAS. Verificou-se que, em todos os períodos, os frangos do genótipo Colorpak apresentaram maior peso corporal, consumo de ração médio diário, ganho em peso médio diário e melhor conversão alimentar. Entretanto, os genótipos Caboclo e Gigante Negro apresentaram menores consumo de ração médio diário, ganho de peso médio diário e pior conversão alimentar. Quanto ao rendimento de cortes, observou-se que os genótipos Caboclo e Gigante Negro apresentaram os menores valores, e o Carijó, Colorpak, Pesadão Vermelho, Pescoço Pelado e Tricolor obtiveram os melhores rendimentos de pernas. Para o rendimento de peito, o Carijó e o Pesadão Vermelho obtiveram os maiores valores. A escolha do genótipo deve ser feita de acordo com o interesse do mercado, pois há diferenças no desempen