WorldWideScience

Sample records for melanoma practicum breeze

  1. Melanoma

    Science.gov (United States)

    ... Lentigo maligna melanoma; Melanoma in situ; Superficial spreading melanoma; Nodular melanoma; Acral lentiginous melanoma ... and brown. It is most common in Caucasians. Nodular melanoma usually starts as a raised area that is ...

  2. Melanoma

    Science.gov (United States)

    Melanoma is the most serious type of skin cancer. Often the first sign of melanoma is a change in the size, shape, color, or feel of a mole. Most melanomas have a black or black-blue area. Melanoma ...

  3. Melanoma

    Science.gov (United States)

    ... if they're dark skinned, young, and have no family history. Even for them, behaviors like too much sun exposure and not enough skin protection are important risk factors. How Do People Know They Have It? Many melanomas start out as a mole or a bump ...

  4. Interaction between a wildfire and the sea-breeze front

    Science.gov (United States)

    Deborah E. Hanley; Philip Cunningham; Scott Goodrick

    2013-01-01

    Florida experiences sea breezes, lake breezes, and bay breezes almost every day during the year, and there are frequently complex interactions between many of these breezes. Given the often-rapid changes in temperature, humidity, and wind speed that accompany these breezes, most wildfires and prescribed fires in Florida are affected in some way by their interaction...

  5. The Sea Breeze Circulation during the Land Sea Breeze Experiment (LASBEX) in Central California

    Science.gov (United States)

    1988-09-01

    conditions, an offshore gradient wind will generate a frontal zone at tie leading cde of a sea breeze .\\tkin, on, 19 1). Estoque 1962) notes in his model...the sodar in the de - tection and mappin2 of sea breeze events and to compare its measured wrind field with that of the lidar. A case study on 16...lidar operated under computer control and had real-time data processing and color display capabiiites. Tile system could compute the zero, first and

  6. Workplace-Based Practicum: Enabling Expansive Practices

    Science.gov (United States)

    Pridham, Bruce A.; Deed, Craig; Cox, Peter

    2013-01-01

    Effective pre-service teacher education integrates theoretical and practical knowledge. One means of integration is practicum in a school workplace. In a time of variable approaches to, and models of, practicum, we outline an innovative model of school immersion as part of a teacher preparation program. We apply Fuller and Unwin's (2004) expansive…

  7. Innovative Approach to Senior Practicum Students.

    Science.gov (United States)

    Golightly, Melissa; Kennett, Natalie; Stout, Jacqueline A

    2017-12-01

    Traditional senior practicum experiences (SPEs) are microsystem based-they allow senior nursing students the opportunity to build professional nursing competencies as they transition into practice. As health care transformation continues unabated, there is a need to work toward closing the gap between nursing academia and nursing practice. A cardiovascular service line created an innovative SPE to better prepare senior nursing students for working as professional nurses in a service line model. The Senior Practicum Immersion Experience (SPIE) proved to be beneficial to senior practicum students and offered firsthand experience of the role professional nurses play in a service line model. This model increased the number of senior practicum students accepted into the cardiac service line by 50%. The SPIE creates an innovative solution to increasing the number of senior practicum students while allowing students the ability to learn and practice in a service line model. [J Nurs Educ. 2017;56(12):745-747.]. Copyright 2017, SLACK Incorporated.

  8. A Climatology of the Sea Breeze at Cape Canaveral, Florida

    Science.gov (United States)

    1997-08-22

    performed. The majority of sea-breeze studies have utilized two-dimensional numerical models (e.g., Walsh 1974; Arritt 1993; Estoque 1962; Bechtold et...The large-scale flow has a significant influence on the sea breeze (e.g., Zhong and 20 Takle 1993; Estoque 1962; Arritt 1993; Bechtold et al. 1991...the temperature gradient and the sea breeze ( Estoque 1962; Arritt 1993; Bechtold et al. 1991; Xian and Pielke 1991). The horizontal temperature

  9. Urban effects of Chennai on sea breeze induced convection and ...

    Indian Academy of Sciences (India)

    Department of Marine, Earth and Atmospheric Sciences, North Carolina State University,. Raleigh, NC ... convergence along the sea breeze front. Shape. Keywords. Convection; sea breeze; urban heat island. J. Earth Syst. Sci. 117, No. 6, December 2008, pp. 897–909 .... (hollow diamond data points) measured over the.

  10. Counseling Practicum as a Facilitator of Self-Actualization.

    Science.gov (United States)

    Osborne, John W.; Steeves, Liliane

    1982-01-01

    Uses 12 subscale scores on the Personal Orientation Inventory to assess effects of a practicum experience upon self-actualization of 79 University of Alberta graduate students (counseling students with and without practicum, and noncounseling students). Results indicate a facilitative effect of practicum upon self-actualization. (AH)

  11. Creative practicum leadership experiences in rural settings.

    Science.gov (United States)

    Schoenfelder, Deborah Perry; Valde, Jill Gaffney

    2009-01-01

    Rural healthcare systems provide rich learning environments for nursing students, where strong nursing leaders manage care for people with diverse health problems across the lifespan. The authors describe the development, implementation, and evaluation of rural clinical leadership practicum, a prelicensure course that specifically focuses on the application of leadership concepts in small rural healthcare systems.

  12. Understanding Undergraduate Students Practicum Experience: A ...

    African Journals Online (AJOL)

    The purpose of this study was to examine the pre-service teachers' perspectives of practicum experience as a tool of learning to teach by using qualitative research methods. Data were collected through interview from twenty four purposively selected information rich participants' ranging in diversity. The data were analyzed ...

  13. The Teaching Practicum in Thailand: Three Perspectives

    Science.gov (United States)

    Phairee, Chatpong; Sanitchon, Nalinee; Suphanangthong, Irada; Graham, Steve; Prompruang, Jidapa; de Groot, Freek Olaf; Hopkins, Dave

    2008-01-01

    This article examines the teaching practicum in Thailand as it occurs in three settings: "Rajabhats"--four-year universities which offer an additional period of teaching practice, and where the vast majority of EFL teachers are educated; regular universities; and a TESOL short course certificate program for non-Thais preparing to teach…

  14. Practicum Experience In Teacher Education | Tuli | Ethiopian ...

    African Journals Online (AJOL)

    It is, therefore, argued that the academic program of the teacher education should be coupled with an important and integral component called school -based experiences i.e. practicum which provides students with supervised experiences and help the student teachers to understand the full scope of teachers role.

  15. FEHR-PRACTICUM: Game Manager's Manual.

    Science.gov (United States)

    Collet, LeVerne S.

    The Formative Evaluation and Heuristic Research (FEHR) PRACTICUM, a computerized game, gives practical experience in such program evaluation tasks as problem definition, operationalizing objectives, field study, budgeting, proposal writing, data analysis, and interpretation--without the expense and time commitments required by most research. The…

  16. Climatology and Analysis of the Monetary Bay Sea Breeze

    Science.gov (United States)

    1993-09-01

    the time it has to take effect. Surface evapotranspiration describes moisture evaporation from the surface or transpiration from vegetation stomata ...heat is a function of the maturity of plant life. The peculiarities of coastal topography vary in its effects on the sea breeze circulation. Four...presented in this section. Fig. 57 shows the evolution of the sea breeze index and stratus coverage for the period 28 July to 3 August 1993. Although this

  17. Melanoma genetics

    DEFF Research Database (Denmark)

    Read, Jazlyn; Wadt, Karin A W; Hayward, Nicholas K

    2015-01-01

    Approximately 10% of melanoma cases report a relative affected with melanoma, and a positive family history is associated with an increased risk of developing melanoma. Although the majority of genetic alterations associated with melanoma development are somatic, the underlying presence of herita......Approximately 10% of melanoma cases report a relative affected with melanoma, and a positive family history is associated with an increased risk of developing melanoma. Although the majority of genetic alterations associated with melanoma development are somatic, the underlying presence...... in a combined total of approximately 50% of familial melanoma cases, the underlying genetic basis is unexplained for the remainder of high-density melanoma families. Aside from the possibility of extremely rare mutations in a few additional high penetrance genes yet to be discovered, this suggests a likely...... polygenic component to susceptibility, and a unique level of personal melanoma risk influenced by multiple low-risk alleles and genetic modifiers. In addition to conferring a risk of cutaneous melanoma, some 'melanoma' predisposition genes have been linked to other cancers, with cancer clustering observed...

  18. Fragments on teachers' reflective practicum

    Directory of Open Access Journals (Sweden)

    Živković Predrag Ž.

    2013-01-01

    (Schon, 1987. This presents, almost unexpectedly and suddenly, two types of reflection (1 reflection on action which occurs during the action interrupting and interfering with it, and (2 reflections in action which appears in the action as well as in the disruption and interruption, so that we think about her and about how to reshape the action that takes place in the moments of reflection. The idea of reflective practitioners (educators, adult educators, sociologists, etc., or a practitioner who thinks about his/her own practice and the practice of reflection draws on its theoretical origins that Schon develops almost like an original idea that became well-known. He assumes that the practice of practical activities (such as teaching, instruction, therapeutic work of doctors or therapists constitutes an original and very specific epistemology. Contrary to the dominant technical rationality that underpins modern professional education, Schon believes that professional knowledge and competence includes the effect of successful practitioners (educators, adult educators, teachers, etc., especially in reflection-in-action (''reflection of what we do while doing'' (Schon, 1986, which appears in problem situations. Hence, the practical education of the profession, according to the author, necessarily follows the model of learning by doing a particular kind of apprenticeship modelled on the training of musicians, artists and drama artists. In his second book (The Reflective Practitioner, Schon develops reflective practicum and confronts it with a dominant, normative curriculum, which constitutes the basis of theoretical knowledge to solve practical, instrumental problems. Practice, however, that is often characterized by uncertainty in this case does not become one solution, but the solution depends on the choice of the value of paragraph, depending on what aspect of the situation we pay more attention to. Schon distinguishes knowledge in action, what implicit knowledge is

  19. Simulation of the sea breeze front with a model of moist convection

    NARCIS (Netherlands)

    Berg, L.C.J. van de; Oerlemans, J.

    1985-01-01

    Although in general the sea breeze can be considered as a mesoscale atmospheric circulation, the sea-breeze front has a much smaller scale. Simulation of the development of a sea-breeze front should therefore be preferably done with a non-hydrostatic model, with high spatial resolution (grid

  20. Structured Peer Group Practicum Supervision: Supervisees' Perceptions of Supervision Theory.

    Science.gov (United States)

    Starling, Paulette V.; Baker, Stanley B.

    2000-01-01

    Discusses a thematic analysis of retrospective phenomenological interviews with four group counseling practicum participants. Suggests the importance of peer feedback supports experimenting with different approaches to the group process. Recommends future research on the impact of group counseling practicum supervision be structured to allow…

  1. Research on Teaching Practicum--A Systematic Review

    Science.gov (United States)

    Lawson, Tony; Çakmak, Melek; Gündüz, Müge; Busher, Hugh

    2015-01-01

    The aim of the present study is to conduct a systematic review research which focuses on research studies into the school practicum. In order to identify the main issues and also to provide a contemporary picture of practicum, 114 studies published on the topic are reviewed and analysed in terms of: (i) aims, (ii) main participants, (iii)…

  2. Benefits and Challenges of Supervising an International Practicum

    Science.gov (United States)

    Gilliland, Betsy

    2015-01-01

    In this reflective essay, I share my experiences as a US-based professor leading graduate students on a 2-month teaching practicum in northern Thailand. I describe the process of arranging the practicum in coordination with the host university and the challenges of teaching 2 teacher-education courses while also mentoring novice teachers and…

  3. Burning out during the Practicum: The Case of Teacher Trainees

    Science.gov (United States)

    Kokkinos, Constantinos M.; Stavropoulos, George

    2016-01-01

    The purpose of the present study was to empirically examine the link between practicum-related stressors, perceived general practicum stress, personal variables (i.e. general and teaching self-efficacy, epistemological beliefs, conceptions about teaching and learning, and trait anxiety) and burnout dimensions in a sample of 174 Greek student…

  4. Student Perceptions of Online Practicum: A Case Study

    Science.gov (United States)

    Wilcox, Gabrielle; Lock, Jennifer

    2017-01-01

    The purpose of the study was to investigate practicum students' perceptions of their experience with an online practicum course in an Applied School Psychology graduate program. With the use of synchronous and asynchronous communication technology, the instructor and students met in the online environment to engage in discussion with regard to…

  5. Gestalt Therapy and the Counseling Practicum: A Marriage.

    Science.gov (United States)

    Witchel, Robert

    This paper briefly summarizes the literature relating to the counseling practicum experience, as well as reviews the development and basic principles of Gestalt therapy. A marriage between the Gestalt therapy approach and the counseling practicum is developed as follows: "Experiential learning, the here-and-now, I-and-thou, and integrating…

  6. A Coastal Bay Summer Breeze Study, Part 2: High-resolution Numerical Simulation of Sea-breeze Local Influences

    Science.gov (United States)

    Calmet, Isabelle; Mestayer, Patrice G.; van Eijk, Alexander M. J.; Herlédant, Olivier

    2018-04-01

    We complete the analysis of the data obtained during the experimental campaign around the semi circular bay of Quiberon, France, during two weeks in June 2006 (see Part 1). A reanalysis of numerical simulations performed with the Advanced Regional Prediction System model is presented. Three nested computational domains with increasing horizontal resolution down to 100 m, and a vertical resolution of 10 m at the lowest level, are used to reproduce the local-scale variations of the breeze close to the water surface of the bay. The Weather Research and Forecasting mesoscale model is used to assimilate the meteorological data. Comparisons of the simulations with the experimental data obtained at three sites reveal a good agreement of the flow over the bay and around the Quiberon peninsula during the daytime periods of sea-breeze development and weakening. In conditions of offshore synoptic flow, the simulations demonstrate that the semi-circular shape of the bay induces a corresponding circular shape in the offshore zones of stagnant flow preceding the sea-breeze onset, which move further offshore thereafter. The higher-resolution simulations are successful in reproducing the small-scale impacts of the peninsula and local coasts (breeze deviations, wakes, flow divergences), and in demonstrating the complexity of the breeze fields close to the surface over the bay. Our reanalysis also provides guidance for numerical simulation strategies for analyzing the structure and evolution of the near-surface breeze over a semi-circular bay, and for forecasting important flow details for use in upcoming sailing competitions.

  7. Improving the Quality of Practicum Learning: Self-Study of a Faculty Member's Role in Practicum Supervision

    Science.gov (United States)

    Russell, Tom

    2017-01-01

    This self-study of activities as a practicum supervisor in several secondary schools focuses on the supervisor's contribution to the quality of a teacher candidate's professional learning in the context of a familiar tension between on-campus courses and in-school practicum experiences. Data from both formal and informal supervisory experiences…

  8. Urban effects of Chennai on sea breeze induced convection and ...

    Indian Academy of Sciences (India)

    High-resolution MM5 simulations were used to investigate the influence of Chennai urban land use on sea breeze initiated convection and precipitation. A comparison of observed and simulated 10 m wind speed and direction over Chennai showed that the model was able to simulate the timing and strength of the sea ...

  9. Numerical simulation of sea breeze characteristics observed at ...

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    mesoscale phenomena, which play an important role in coastal areas where industries are located and a large population resides. Many have dis- cussed the importance of the study of sea breeze for problems such as air pollution transport, location and initiation of convection, aviation safety, glid- ing and sailing, and forest ...

  10. Numerical simulation of sea breeze characteristics observed at ...

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    Sea breeze characteristics around Kalpakkam tropical coastal site are studied using an Advanced. Regional Prediction System (ARPS) .... long wave radiation divergence, the use of flux pro- file relationships parameterized for ... Advanced Regional Prediction System (ARPS),. (Xue et al 2000; 2001) is a storm and ...

  11. The monsoon system: Land–sea breeze or the ITCZ?

    Indian Academy of Sciences (India)

    Sulochana Gadgil

    2018-01-27

    –sea breeze driven by the land–ocean contrast in surface temperature. In this paper, this hypothesis and its implications for the variability of the monsoon are discussed and it is shown that the observations of monsoon ...

  12. Students’ Perception on Teaching Practicum Evaluation using Video Technology

    Science.gov (United States)

    Chee Sern, Lai; ‘Ain Helan Nor, Nurul; Foong, Lee Ming; Hassan, Razali

    2017-08-01

    Video technology has been widely used in education especially in teaching and learning. However, the use of video technology for evaluation purpose especially in teaching practicum is extremely scarce and the benefits of video technology in teaching practicum evaluation have not yet been fully discovered. For that reason, this quantitative research aimed at identifying the perceptions of trainee teachers towards teaching practicum evaluation via video technology. A total of 260 students of Teacher Certification Programme (Program Pensiswazahan Guru - PPG) from the Faculty of Technical and Vocational Education (FPTV) of Universiti Tun Hussein Onn Malaysia (UTHM) had been randomly selected as respondents. A set of questionnaire was developed to assess the suitability, effectiveness and satisfaction of using video technology for teaching practicum. Conclusively, this research showed that the trainee teachers have positive perceptions in all three aspects related teaching practicum evaluation using video technology. Apart from that, no significant racial difference was found in the measured aspects. In addition, the trainee teachers also showed an understanding of the vast importance of teaching practicum evaluation via video. These research findings suggest that video technology can be a feasible and practical means of teaching practicum evaluation especially for distance learning program.

  13. Thin melanoma.

    Science.gov (United States)

    Elder, David E

    2011-03-01

    The incidence of malignant melanoma is increasing and a preponderance of the melanomas diagnosed today are "thin in terms of Breslow criteria. Although thin melanomas, as a group, are associated with a very good prognosis, a subset of these tumors may metastasize and cause death. These cases can be identified by using prognostic models, including the "standard" American Joint Committee on Cancer criteria, and other attributes identified in follow-up studies. To review the history of concepts of prognostic modeling in melanoma, focusing on thin melanomas. Selected literature. About 40 years ago, it was realized that malignant melanoma, once almost uniformly fatal, could be divided into categories with better or worse prognosis through the use of prognostic models. The first simple models, Clark levels of invasion and Breslow thickness, are still in use. Thickness remains the single most useful variable. Breslow recognized that melanomas less than 0.76 mm in thickness were associated with a very good prognosis, with no metastases in his limited initial study. The American Joint Committee on Cancer selected a cutoff of 1.0 mm, which achieves a similar result, with stage modifiers, although some metastases and deaths do occur with stage I lesions. Clark demonstrated an almost equally good prognosis for his level II invasive melanomas and recognized that most of these lesions, although invasive, lacked the ability to form tumors or to undergo mitosis in the dermis and were therefore "nontumorigenic" and "nonmitogenic" and lacked competence for metastasis. Studies of these low-risk melanomas have led to the development of criteria for earlier diagnosis and a steady, but still inadequate, improvement in prognosis for melanoma overall. Multivariable models currently can identify groups of patients within the "thin melanoma" category whose prognosis varies, from a disease-free survival of close to 100% to about 70%. Prognosis declines more or less linearly with increasing

  14. Ocular Melanoma

    Science.gov (United States)

    ... also occur on the conjunctiva . Because most eye melanomas form in the part of the eye you can’t see when looking in a mirror, they can be difficult to detect. Also, eye melanoma typically doesn’t cause early signs or symptoms . ...

  15. Malignant melanoma

    NARCIS (Netherlands)

    de Braud, Filippo; Khayat, David; Kroon, Bin B. R.; Valdagni, Riccardo; Bruzzi, Paolo; Cascinelli, Natale

    2003-01-01

    In the European Community cutaneous melanoma accounts for 1 and 1.8% of cancers occurring in men and women, respectively. The incidence rate is increasing faster than that of any other tumour. Sun exposure, patient's phenotype, family history, and history of a previous melanoma are the major risk

  16. Practicum y evaluación de competencias

    Directory of Open Access Journals (Sweden)

    Aurelio Villa Sánchez

    2004-01-01

    Full Text Available El artículo destaca el papel del Practicum en el desarrollo de competencias que permitan la transferencia de conocimientos a situaciones de trabajo, en congruencia con el enfoque del Proceso de Convergencia Europea de Educación Superior. Señala los elementos clave de un Practicum, el sentido y significado que en él adquieren las competencias y el significado que cobra como espacio ideal para evaluarlas. En consecuencia, sugieren ideas dirigidas a orientar el modo de incorporar la evaluación de competencias en la evaluación del Practicum.

  17. A breeze-driven current on sloped littoral waters

    Science.gov (United States)

    Tohidi, A.; Jamali, M.

    2017-12-01

    Various natural phenomena, e. g. uniform/non-uniform solar radiation and diurnal cycles, affect water circulation patterns through aquatic canopies, that is (usually shallow) shorelines of the rivers, lakes, and lagoons. Amongst these factors is vegetation that, plays a crucial role in conserving and dispersing the nutrients, oxygen, temperature, and generally regulating the life and interactions of organisms with each other (ecology) in aquatic canopies. So far, however, very little attention has been paid to the effects of very low, breeze-like, winds over the water surface in these vegetated regions. In this exploratory study, the evolution of a breeze-driven gravity current traveling up the slope towards the shorelines is shown, experimentally. The flow is characterized using Particle Image Velocimetry (PIV) technique. In addition, a detailed dimensional analysis of the parameter space of the phenomenon is conducted. The results strongly corroborate the experimental observations.

  18. The properties of coke breeze briquettes produced by ram briquetting

    Science.gov (United States)

    Loginov, Yu. N.; Babailov, N. A.; Polyansky, L. I.

    2017-12-01

    The paper reports on the results of briquetting coke breeze with a binder in a closed cylindrical press-die. Liquid glass is used as a binder. Approximating curves for the "compaction ratio vs. compaction pressure" dependences are plotted from experimental data. The mechanical properties of the briquettes are determined, namely, drop damage resistance and breaking stress. The results are presented as approximating dependences in the form of a power function.

  19. Granulation of coke breeze fine for using in the sintering process

    Directory of Open Access Journals (Sweden)

    Mohamed F.M.

    2010-01-01

    Full Text Available Coke breeze is the main fuel used in the sintering process. The value of -3+1 mm. represents the most favorable particle size for coke breeze in the sintering process. About 20% of total coke fines (-0.5 mm are produced during different steps of preparation. Introducing these fines during the sintering process proves to be very harmful for different operating parameters. Thus ,this study aims at investigating the production of granules resulting from these fines using molasses as organic binder and its application in sintering of an iron ore. The results showed that the granules having the highest mechanical properties were obtained with 14.5 wt % molasses addition. The sintering experiments were performed by using coke breeze in different shapes (-3+1 mm in size, coke breeze without sieving and coke breeze granules -3+1 mm. The reduction experiments, microscopic structure and X-ray analysis for the produced sinter were carried out. The results revealed that, all sinter properties (such as shatter test, productivity of sinter machine and blast furnace, reduction time and chemical composition for produced sinter by using coke breeze with size -3+1 mm and coke breeze granules were almost the same. The iron ore sinter which was produced by using coke breeze without sieving yielded low productivity for both sinter machine and blast furnace. Furthermore, using coke breeze without sieving in sintering of an iron ore decreases the vertical velocity of sinter machine and increases the reduction time.

  20. Meteorological and Land Surface Properties Impacting Sea Breeze Extent and Aerosol Distribution in a Dry Environment

    Science.gov (United States)

    Igel, Adele L.; van den Heever, Susan C.; Johnson, Jill S.

    2018-01-01

    The properties of sea breeze circulations are influenced by a variety of meteorological and geophysical factors that interact with one another. These circulations can redistribute aerosol particles and pollution and therefore can play an important role in local air quality, as well as impact remote sensing. In this study, we select 11 factors that have the potential to impact either the sea breeze circulation properties and/or the spatial distribution of aerosols. Simulations are run to identify which of the 11 factors have the largest influence on the sea breeze properties and aerosol concentrations and to subsequently understand the mean response of these variables to the selected factors. All simulations are designed to be representative of conditions in coastal sub tropical environments and are thus relatively dry, as such they do not support deep convection associated with the sea breeze front. For this dry sea breeze regime, we find that the background wind speed was the most influential factor for the sea breeze propagation, with the soil saturation fraction also being important. For the spatial aerosol distribution, the most important factors were the soil moisture, sea-air temperature difference, and the initial boundary layer height. The importance of these factors seems to be strongly tied to the development of the surface-based mixed layer both ahead of and behind the sea breeze front. This study highlights potential avenues for further research regarding sea breeze dynamics and the impact of sea breeze circulations on pollution dispersion and remote sensing algorithms.

  1. Spatial-temporal Detection of Sea-breeze Penetration Over Megacities from Himawari-8

    Science.gov (United States)

    Ferdiansyah, M. R.; Inagaki, A.; Kanda, M.

    2017-12-01

    For a coastal urban region, sea breeze is very important for air ventilation and cooling. However, most of sea-breeze monitoring is lacking and inadequate temporally and spatially. Japanese new geostationary meteorological satellite (Himawari-8) has been launched which can provide high resolution satellite imagery. This enables better monitoring of mesoscale weather phenomena such as sea breeze. In this study, we first attempt the feasibility of acquiring temporal-spatial information of sea breeze in a coastal urban region using Himawari-8. For study area, Tokyo (Japan) and Jakarta (Indonesia) area were selected as representative coastal urban regions; both cities located in very distant latitudes. Sea breeze events (Tokyo:16 cases and Jakarta:17 cases) in JAS season of 2015 and 2016 were analyzed. Convergence zones of two sea-breeze systems and delayed sea-breeze penetration were found for both Tokyo and Jakarta. Estimation of inland penetration speed and convergence area for sea breeze event, accompanied by the formation of non-precipitating cumulus type cloudline, is the primary objective. From the visible band image of Himawari-8, cumulus cloudline for each sea breeze event was extracted. The inland penetration speed was then estimated automatically from temporal evolution of these cloudlines. For the case of Tokyo, it was found that the sea breeze from Tokyo Bay had slower penetration speed than another sea breeze (Sagami Bay) coming from a less urbanized area. The average penetration speed of sea-breeze front was estimated to be 3.6 m/s and 1.3 m/s for sea breeze from Sagami Bay and Tokyo Bay, respectively. The penetration differences (from Sagami Bay and Tokyo Bay) could be attributed to the difference in urbanization levels between the coastal areas of Sagami and Tokyo Bay. For the case of Jakarta, the convergence of two sea-breeze systems were found persistent slightly east from the center of Jakarta. Interestingly, the sea-breeze delay was more pronounced

  2. Malignant Melanoma

    Directory of Open Access Journals (Sweden)

    Eshini Perera

    2013-12-01

    Full Text Available Melanomas are a major cause of premature death from cancer. The gradual decrease in rates of morbidity and mortality has occurred as a result of public health campaigns and improved rates of early diagnosis. Survival of melanoma has increased to over 90%. Management of melanoma involves a number of components: excision, tumor staging, re-excision with negative margins, adjuvant therapies (chemo, radiation or surgery, treatment of stage IV disease, follow-up examination for metastasis, lifestyle modification and counseling. Sentinel lymph node status is an important prognostic factor for survival in patients with a melanoma >1 mm. However, sentinel lymph node biopsies have received partial support due to the limited data regarding the survival advantage of complete lymph node dissection when a micrometastasis is detected in the lymph nodes. Functional mutations in the mitogen-activated pathways are commonly detected in melanomas and these influence the growth control. Therapies that target these pathways are rapidly emerging, and are being shown to increase survival rates in patients. Access to these newer agents can be gained by participation in clinical trials after referral to a multidisciplinary team for staging and re-excision of the scar.

  3. Review of MPH practicum requirements in accredited schools of public health.

    Science.gov (United States)

    Oglesby, Willie H; Alemagno, Sonia A; Zullo, Melissa D; Hartman, Olivia; Smith, Katalin; Smith, Joseph; Buzzelli, Michael

    2013-06-01

    Accreditation criteria by the Council on Education for Public Health (CEPH) state that prior to graduation, Masters of Public Health (MPH) students must demonstrate the application of knowledge and skills through a practice experience, commonly called the "Practicum." The purpose of this research was to review those MPH Practicum requirements. Practicum guidelines from US-based schools of public health that were accredited as of October 2011 were reviewed. Data on each Practicum's level of coordination, timing, and credit and contact hours as well as information about written agreements, preceptors, and how the Practicum was graded were collected. Seventy-four Practicums in 46 accredited schools of public health were reviewed. The majority (85 %) of accredited schools controlled the Practicum at the school-level. Among the Practicums reviewed, most did not require completion of any credit hours or the MPH core courses (57 and 74 %, respectively) prior to starting the Practicum; 82 % required written agreements; 60 % had stated criteria for the approval of preceptors; and 76 % required students to submit a product for grading at the conclusion of the Practicum. The results of this research demonstrate that the majority of accredited schools of public health designed Practicum requirements that reflect some of the criteria established by CEPH; however, issues related to timing, credit and contact hours, and preceptor qualifications vary considerably. We propose that a national dialogue begin among public health faculty and administrators to address these and other findings to standardize the Practicum experience for MPH students.

  4. ECO RISK MANAGEMENT IN MINING, ECO PRACTICUM

    Directory of Open Access Journals (Sweden)

    Slobodan Radosavljević

    2011-11-01

    Full Text Available Environmental protection is a key factor for sustainable development in the area of exploitationof natural energy resources. Solving problems in this field requires a quality strategic positioning ecoexploitation sites, which is the most burdened by environmental problems, based on modernscientific approaches and definitions. Realistically frequent criticism and environmental hazards inmining the potential of various statements. There is a long-term disruption of natural flow and overallecological balance of the system. Demonstrated environmental destruction and damage of smaller orlarger extent the result, which can be accessed from the aspect of taking corrective action by the state.A complex analysis of the causes, the analysis of environmental risks and the definition of preventiveenvironmental strategy, hardly can speak, at least in the forms of modern analytical andmethodological approaches. The basis of determining the initiation of interest on takingresponsibility for local environmental priorities and their protection in areas of intensive exploitationof works. It is a negative impact on human health and the need to preserve the total ecosystem.Analysis of environmental risks is becoming logistically purpose and need with which to be flexible,adaptable, and efficiently organize and manage access to environmental reality and truth in thecontext of improvements, now and in the near future. This paper presents real experiences andresearch results in environmental practicum proposals and implementation of modern concepts,methods and models for the analysis of environmental risks.

  5. Uveal Melanoma

    International Nuclear Information System (INIS)

    Papastefanou, V. P.; Cohen, V. M. L.; Cohen, V. M. L.

    2011-01-01

    Uveal melanoma is the most common primary intraocular malignancy and the leading primary intraocular disease which can be fatal in adults. In this paper epidemiologic, pathogenetic, and clinical aspects of uveal melanoma are discussed. Despite the advance in local ocular treatments, there has been no change in patient survival for three decades. Development of metastases affects prognosis significantly. Current survival rates, factors predictive of metastatic potential and metastatic screening algorithms are discussed. Proposed and emerging treatments for uveal melanoma metastases are also overviewed. Current advances in genetics and cytogenetics have provided a significant insight in tumours with high metastatic potential and the molecular mechanisms that underlie their development. Biopsy of those lesions may prove to be important for prognostication and to allow further research into genetic mutations and potential new therapeutic targets in the future

  6. Application of fine-grained coke breeze fractions in the process of iron ore sintering

    Directory of Open Access Journals (Sweden)

    M. Niesler

    2014-01-01

    Full Text Available The testing cycle, described in the paper, included fine-grained coke breeze granulation tests and iron concentrate sintering tests with the use of selected granulate samples. The use of granulated coke breeze in the sintering process results in a higher process efficiency, shorter sintering duration and fuel saving.

  7. Estimating the seaward extent of sea breeze from QuickSCAT scatterometry

    Digital Repository Service at National Institute of Oceanography (India)

    Aparna, M.; Shetye, S.R.; Shankar, D.; Shenoi, S.S.C.; Mehra, P.; Desai, R.G.P.

    to estimate the seaward extent of the sea breeze using QuikSCAT data. Citation: Aparna, M., S. R. Shetye, D. Shankar, S. S. C. Shenoi, P. Mehra, and R. G. P. Desai (2005), Estimating the seaward extent of sea breeze from QuikSCAT scatterometry, Geophys. Res...

  8. Observations of Lake-Breeze Events During the Toronto 2015 Pan-American Games

    Science.gov (United States)

    Mariani, Zen; Dehghan, Armin; Joe, Paul; Sills, David

    2018-01-01

    Enhanced meteorological observations were made during the 2015 Pan and Parapan American Games in Toronto in order to measure the vertical and horizontal structure of lake-breeze events. Two scanning Doppler lidars (one fixed and one mobile), a C-band radar, and a network including 53 surface meteorological stations (mesonet) provided pressure, temperature, humidity, and wind speed and direction measurements over Lake Ontario and urban areas. These observations captured the full evolution (prior, during, and after) of 27 lake-breeze events (73% of observation days) in order to characterize the convective and dynamic processes driving lake breezes at the local scale and mesoscale. The dominant signal of a passing lake-breeze front (LBF) was an increase in dew-point temperature of 2.3 ± 0.3°C, coinciding with a 180° shift in wind direction and a decrease in air temperature of 2.1 ± 0.2°C. Doppler lidar observations over the lake detected lake breezes 1 hour (on average) before detection by radar and mesonet. On days with the synoptic flow in the offshore direction, the lidars observed wedge-shaped LBFs with shallow depths, which inhibited the radar's ability to detect the lake breeze. The LBF's ground speed and inland penetration distance were found to be well-correlated (r = 0.78), with larger inland penetration distances occurring on days with non-opposing (non-offshore) synoptic flow. The observed enhanced vertical motion ({>} 1 m s^{-1}) at the LBF, observed by the lidar on 54% of lake-breeze days, was greater (at times {>} 2.5 m s^{-1}) than that observed in previous studies and longer-lasting over the lake than over land. The weaker and less pronounced lake-breeze structure over land is illustrated in two case studies highlighting the lifetime of the lake-breeze circulation and the impact of propagation distance on lake-breeze intensity.

  9. Malignant Melanoma of the Foot

    Science.gov (United States)

    ... Javascript in your browser. Malignant Melanoma of the Foot What Is Malignant Melanoma? Melanoma is a cancer ... age groups, even the young. Melanoma in the Foot Melanoma that occurs in the foot or ankle ...

  10. Lake breezes in the southern Great Lakes region and their influence during BAQS-Met 2007

    Directory of Open Access Journals (Sweden)

    D. M. L. Sills

    2011-08-01

    Full Text Available Meteorological observations from the BAQS-Met field experiment during the summer months of 2007 were integrated and manually analyzed in order to identify and characterize lake breezes in the southern Great Lakes region of North America, and assess their potential impact on air quality. Lake breezes occurred frequently, with one or more lake breezes identified on 90 % of study days. They affected all parts of the study region, including southwestern Ontario and nearby portions of southeast Lower Michigan and northern Ohio, with lake-breeze fronts occasionally penetrating from 100 km to over 200 km inland. Occurrence rates and penetration distances were found to be higher than previously reported in the literature. This comprehensive depiction of observed lake breezes allows an improved understanding of their influence on the transport, dispersion, and production of pollutants in this region.

    The observational analyses were compared with output from subsequent runs of a high-resolution numerical weather prediction model. The model accurately predicted lake breeze occurrence and type in a variety of synoptic wind regimes, but selected cases showed substantial differences in the detailed timing and location of lake-breeze fronts, and with the initiation of deep moist convection. Knowledge of such strengths and weaknesses aids in the interpretation of results from air quality models driven by this meteorological model.

  11. Fostering Theory-Practice Reflection in Teaching Practicums

    Science.gov (United States)

    Stenberg, Katariina; Rajala, Antti; Hilppo, Jaakko

    2016-01-01

    This article presents a design for supporting theory-practice reflection in teacher practicums. This design is based on three design principles that promote a transformative stance towards the creation of novel pedagogical approaches: mutual transformation of theory and practice, co-design among supervising teachers, university lecturers and…

  12. Self-Actualization Level as Predictor of Practicum Supervision Effectiveness.

    Science.gov (United States)

    Deming, Anne L.

    1980-01-01

    Counselor growth in self-actualization was not affected by the level of self-actualization of the supervisor. Counseling students gained in self-actualization whether or not they were enrolled in a practicum and regardless of the level of self-actualization of their supervisors. (Author)

  13. Explicating Practicum Program Theory: A Case Example in Human Ecology

    Science.gov (United States)

    Chandler, Kathryn M. M.; Williamson, Deanna L.

    2013-01-01

    This study explicated the theory underpinning the Human Ecology Practicum Program offered in the Department of Human Ecology at the University of Alberta. The program has operated for 40 years but never been formally evaluated. Using a document analysis, focus group and individual interviews, and a stakeholder working group, we explored…

  14. Problematising Practicum Relationships: Questioning the "Taken for Granted"

    Science.gov (United States)

    Haigh, Mavis; Ward, Gillian

    2004-01-01

    We position teaching as a complex, creative profession and have an expectation that practicum should support the reflexive, possibility-thinking and risk-taking creative endeavours of the beginning teacher. This paper reports on a series of studies that explored shared understandings and effectiveness of relationships and roles of practicum…

  15. Using Creativity to Make Practicum a Transformative Experience

    Science.gov (United States)

    Shepard, David S.; Brew, Leah

    2013-01-01

    Students enter their practicum experience with the assumption that they will learn the skills needed to help clients. However, growth in counseling can be bidirectional; both the client and the student-counselor can benefit. The purpose of this article is to describe a creative arts assignment that helps students express how a client changed them,…

  16. Refashioning the Practicum by Emphasizing Attending and Reflective Skills

    Science.gov (United States)

    Oprandy, Robert

    2015-01-01

    In their 1970 guidelines for teacher-preparation programs (TPPs), TESOL's founders promoted practicum experiences that include "systematic directed observation, supervised teaching practice and progressive teaching responsibilities." TPPs with field experiences as centerpieces of their programs have been more effective in meeting the…

  17. The Impact of Facebook in Teaching Practicum: Teacher Trainees' Perspectives

    Science.gov (United States)

    Goktalay, Sehnaz Baltaci

    2015-01-01

    Prompt feedback is one of the critical components of teacher education programs. To reap the greatest benefit from the teaching practicum process, the quality of feedback as well as its implementation by stakeholders, supervisors, cooperating teachers, and teacher trainees, takes on great importance. The purpose of this study is to examine how Web…

  18. The monsoon system: Land–sea breeze or the ITCZ?

    Science.gov (United States)

    Gadgil, Sulochana

    2018-02-01

    For well over 300 years, the monsoon has been considered to be a gigantic land-sea breeze driven by the land-ocean contrast in surface temperature. In this paper, this hypothesis and its implications for the variability of the monsoon are discussed and it is shown that the observations of monsoon variability do not support this popular theory of the monsoon. An alternative hypothesis (whose origins can be traced to Blanford's (1886) remarkably perceptive analysis) in which the basic system responsible for the Indian summer monsoon is considered to be the Intertropical Convergence Zone (ITCZ) or the equatorial trough, is then examined and shown to be consistent with the observations. The implications of considering the monsoon as a manifestation of the seasonal migration of the ITCZ for the variability of the Indian summer monsoon and for identification of the monsoonal regions of the world are briefly discussed.

  19. The monsoon system: Land-sea breeze or the ITCZ?

    Science.gov (United States)

    Gadgil, Sulochana

    2018-02-01

    For well over 300 years, the monsoon has been considered to be a gigantic land-sea breeze driven by the land-ocean contrast in surface temperature. In this paper, this hypothesis and its implications for the variability of the monsoon are discussed and it is shown that the observations of monsoon variability do not support this popular theory of the monsoon. An alternative hypothesis (whose origins can be traced to Blanford's (1886) remarkably perceptive analysis) in which the basic system responsible for the Indian summer monsoon is considered to be the Intertropical Convergence Zone (ITCZ) or the equatorial trough, is then examined and shown to be consistent with the observations. The implications of considering the monsoon as a manifestation of the seasonal migration of the ITCZ for the variability of the Indian summer monsoon and for identification of the monsoonal regions of the world are briefly discussed.

  20. Interactions between the thermal internal boundary layer and sea breezes

    Energy Technology Data Exchange (ETDEWEB)

    Steyn, D.G. [The Univ. of British Columbia, Dept. of Geography, Atmospheric Science Programme, Vancouver (Canada)

    1997-10-01

    In the absence of complex terrain, strongly curved coastline or strongly varying mean wind direction, the Thermal Internal Boundary Layer (TIBL) has well known square root behaviour with inland fetch. Existing slab modeling approaches to this phenomenon indicate no inland fetch limit at which this behaviour must cease. It is obvious however that the TIBL cannot continue to grow in depth with increasing fetch, since the typical continental Mixed Layer Depths (MLD) of 1500 to 2000 m must be reached between 100 and 200 km from the shoreline. The anticyclonic conditions with attendant strong convection and light winds which drive the TIBL, also drive daytime Sea Breeze Circulations (SBC) in the coastal zone. The onshore winds driving mesoscale advection of cool air are at the core of TIBL mechanisms, and are invariably part of a SBC. It is to be expected that TIBL and SBC be intimately linked through common mechanisms, as well as external conditions. (au)

  1. The seasonal characteristics of the breeze circulation at a coastal Mediterranean site in South Italy

    DEFF Research Database (Denmark)

    Federico, S.; Pasqualoni, L.; Sempreviva, Anna Maria

    2010-01-01

    We present a study on the characteristics of the sea breeze flow at a coastal site located in the centre of the Mediterranean basin at the southern tip of Italy. This study is finalized to add new data on breeze circulations over a narrow peninsula and present a unique experimental coastal site...... at about 600 m from the coastline in a flat open area at the foot of a mountain chain located in a region of complex orography. We study the seasonal behaviour of the sea-land breeze circulation by analysing two years of hourly data of wind speed and direction, temperature, radiation and relative humidity...

  2. Sinclair swine melanoma

    International Nuclear Information System (INIS)

    Hook, R.R.; Berkelhammer, J.; Hamby, C.V.

    1986-01-01

    Sinclair(S-1) miniature swine spontaneously develop melanomas which have many biologic and histologic features in common with human superficial spreading melanoma. Host control of this neoplasm was indicated by the high incidence of spontaneous regression, a decrease in tumor development with age and a decrease in progressive growth of the tumor as age of tumor development increases. Immunologic mechanisms were implicated in host control by histologic observation of a mononuclear inflammatory infiltration of tumors which lead to depigmentation and fibrosis. In vitro immunologic studies revealed that leukocytes from melanoma swine were sensitized specifically to a tumor associated antigen like substance present in extracts of cutaneous melanomas and cultured swine melanoma cells and that melanoma swine leukocytes were cytotoxic for swine melanoma cells. Furthermore, these studies suggested the existence of a common cross reactive, melanoma associated antigen shared by human and swine melanomas. Antigenic analyses of swine melanomas with mouse monoclonal antibodies developed to a single swine melanoma cell culture and with rabbit antisera developed to pooled extracts of cutaneous melanomas demonstrated the presence of tumor associated antigens in swine melanoma cell culture and cutaneous melanomas. The failure of mouse monoclonal antibodies to detect antigens in cutaneous melanoma extracts and the failure of rabbit antisera to detect antigens in melanoma cell culture extracts suggested a differential in antigen expression between swine melanoma cells grown in vitro and in vivo

  3. Choroidal melanoma

    International Nuclear Information System (INIS)

    Hernandez Quesada, Flora

    2013-01-01

    A useful and practical guide is developed to better track to the uveal melanoma, due to its highly malignant character. Melanoma of the uveal tract (choroid, iris, ciliary body) has been the intraocular tumor most frequent in adults. The biopsy has been inaccessible, due to its location; therefore, the diagnostic should be based on clinical examination and the correct utilization of the diagnostic procedures (ultrasound, fluorescent angiography, computed axial tomography and magnetic resonance). The cases are diagnosed in the histological examination of the operatory piece post-enucleation for other causes. Epidemiological research has been key to determine the associated factors and better to understand the mechanisms of onset of the disease. Anatomopathological studies of choroidal melanoma have permitted to know the natural history of the disease. The decrease of the visual acuity, pain or inflammation are presented as a defect in the visual field. Different techniques to diagnose the disease are explained. Ultrasound in mode A and B, computed axial tomography and magnetic resonance are the diagnostic method of election. Ultrasound has been the primary method of diagnostic, giving the size and vascularisation, useful in tracking, when they are treated in shape conservatively, showing changes in echogenicity and less vascularisation as good response to treatment. The treatments of choroidal melanoma are specified. The correct interpretation of the clinical symptoms and early utilization of diagnostic imaging methods, have permitted to establish the adequate therapeutic and to avoid local and distant metastasis. The uveal melanoma, depending on their size and location, traditionally has been treated by enucleation. Data from the literature and authors, have promoted the conservation of the ocular globe, depending on the size of the tumor. Transpupillary thermotherapy has been an available alternative for small tumors in Costa Rica and level of social security

  4. Sea breeze forcing of estuary turbulence and air-water CO2 exchange

    Science.gov (United States)

    Orton, Philip M.; McGillis, Wade R.; Zappa, Christopher J.

    2010-07-01

    The sea breeze is often a dominant meteorological feature at the coastline, but little is known about its estuarine impacts. Measurements at an anchored catamaran and meteorological stations along the Hudson River and New York Bay estuarine system are used to illustrate some basic characteristics and impacts of the feature. The sea breeze propagates inland, arriving in phase with peak solar forcing at seaward stations, but several hours later at up-estuary stations. Passage of the sea breeze front raises the water-to-air CO2 flux by 1-2 orders of magnitude, and drives turbulence comparable to spring tide levels in the upper meter of the water column, where most primary productivity occurs in this highly turbid system. Modeling and observational studies often use remotely-measured winds to compute air-water fluxes (e.g., momentum, CO2), and this leads to a factor of two flux error on sea breeze days during the study.

  5. Scaling Characteristics of Developing Sea Breezes Simulated in a Water Tank

    Science.gov (United States)

    Yuan, Renmin; Sun, Jianning; Luo, Tao; Wu, Xuping

    2013-09-01

    Sea-breeze circulations in a stably stratified environment have been simulated in a water tank. The floor of the tank was divided into two halves representing land and sea; the land side was heated from the bottom of the tank, and the sea side was insulated by an underlying sponge slab. The temperature profiles over both land and sea sides, the land-sea temperature difference, and the horizontal temperature distributions were measured. Particle tracking velocimetry was applied to obtain the two-dimensional velocity field orthogonal to the coastline. It was shown that the overall flow consists of a closed circulation caused by the horizontal temperature difference between land and sea, and a strong updraft occurring at the sea-breeze front. The dimensionless governing parameters are calculated from the measurements and used to characterize the developing sea breezes. The analysis confirms the scaling laws for sea-breeze velocity and depth. The results indicate that the scaling characteristics of the sea-breeze translation speed during the developing period are different to those during the following maintaining period. A criterion for the onset of the sea breeze is proposed based on these results.

  6. Patterns of Local Circulation in the Itaipu Lake Area: Numerical Simulations of Lake Breeze.

    Science.gov (United States)

    Stivari, Sônia M. S.; de Oliveira, Amauri P.; Karam, Hugo A.; Soares, Jacyra

    2003-01-01

    The lake-breeze circulation in the Itaipu region was investigated numerically using a nonhydrostatic version of the Topographic Vorticity Model. The area of study corresponds to a 100 km × 180 km rectangle, located on the Brazil-Paraguay border, with Itaipu Lake in its center. The characteristics of the lake breeze generated by the numerical experiments were consistent with the observations available in the area. The numerical experiments have shown that the land use effect is important in the spatial distribution of the lake-breeze circulation and that the topography contributes to modulating the breeze intensity, with the daytime valley-mountain circulation intensifying the lake breeze. However, the circulation pattern observed during daytime over the region is mainly due to the Itaipu Lake presence. The numerical results indicated that Itaipu Lake is able to generate and sustain a lake breeze, with 3.5 m s1 of maximum intensity and 1500-m depth, that propagates inland at 5.1 km h1 under typical undisturbed and calm-wind summer conditions.

  7. Professional qualification in Social Education: the role of the Practicum

    Directory of Open Access Journals (Sweden)

    Carmen Pereira Dominguez

    2013-01-01

    Full Text Available This article addresses the role to be performed by the Practicum in the training of social workers. For this purpose we have done a brief tour around the different criteria that have supported the professional development of social education and academic training. It offers thus an epistemological revision has its initial motivation in the need identified in several research projects in which we have participated in over the selection of studies in the early stages of post-compulsory education and compulsory secondary. The analysis of the different actors involved in the process of professionalization of social education and the importance of certain skills, lead us to propose a Practicum able to provide a framework for reflection on professional practices in a learning coordinated context, interdisciplinary and professionalism.

  8. Cixutumumab in Treating Patients With Metastatic Melanoma of the Eye

    Science.gov (United States)

    2015-06-25

    Ciliary Body and Choroid Melanoma, Medium/Large Size; Ciliary Body and Choroid Melanoma, Small Size; Iris Melanoma; Metastatic Intraocular Melanoma; Recurrent Intraocular Melanoma; Stage IV Intraocular Melanoma

  9. Skin cancer and melanoma

    International Nuclear Information System (INIS)

    Moylan, D.J.

    1991-01-01

    In this chapter, the author discusses various types of non-melanoma malignant skin cancer, as well as malignant melanoma. Non-melanoma skin cancer, such as basal cell and squamous cell carcinomas, occasionally metastasize, but only late in the course of the disease. On the other hand, even relatively small primary melanomas tend to disseminate to regional lymph nodes and to distant sites. The author presents various treatment plans, including radiation therapy. Cutaneous melanomas have been considered relatively radioresistant. This is the rationale for the use of large fraction radiation therapy in the treatment of melanomas with the fraction sizes varying from 4--8 Gy

  10. The Role of the Prepracticum in Lessening Student Teacher Stress: Student Teachers' Perceptions of Stress during Practicum

    Science.gov (United States)

    Danyluk, Patricia

    2013-01-01

    Research on the student teaching practicum indicates that it is a time of enormous stress. The purpose of this study was to gather information from student teachers regarding their perceptions of stress while in the midst of their practicum. The questions were designed to gather information that could be used to create a less stressful practicum.…

  11. WARM BREEZE FROM THE STARBOARD BOW: A NEW POPULATION OF NEUTRAL HELIUM IN THE HELIOSPHERE

    Energy Technology Data Exchange (ETDEWEB)

    Kubiak, M. A.; Bzowski, M.; Sokół, J. M.; Swaczyna, P.; Grzedzielski, S. [Space Research Centre of the Polish Academy of Sciences, Warsaw (Poland); Alexashov, D. B.; Izmodenov, V. V. [Space Research Institute (IKI) of the Russian Academy of Sciences, Moscow (Russian Federation); Möbius, E.; Leonard, T. [Space Research Center and Department of Physics, University of New Hampshire, Durham, NH (United States); Fuselier, S. A.; McComas, D. J. [Southwest Research Institute, San Antonio, TX (United States); Wurz, P. [Physics Institute, University of Bern, Bern (Switzerland)

    2014-08-01

    We investigate the signals from neutral helium atoms observed in situ from Earth orbit in 2010 by the Interstellar Boundary Explorer (IBEX). The full helium signal observed during the 2010 observation season can be explained as a superposition of pristine neutral interstellar He gas and an additional population of neutral helium that we call the Warm Breeze. The Warm Breeze is approximately 2 times slower and 2.5 times warmer than the primary interstellar He population, and its density in front of the heliosphere is ∼7% that of the neutral interstellar helium. The inflow direction of the Warm Breeze differs by ∼19° from the inflow direction of interstellar gas. The Warm Breeze seems to be a long-term, perhaps permanent feature of the heliospheric environment. It has not been detected earlier because it is strongly ionized inside the heliosphere. This effect brings it below the threshold of detection via pickup ion and heliospheric backscatter glow observations, as well as by the direct sampling of GAS/Ulysses. We discuss possible sources for the Warm Breeze, including (1) the secondary population of interstellar helium, created via charge exchange and perhaps elastic scattering of neutral interstellar He atoms on interstellar He{sup +} ions in the outer heliosheath, or (2) a gust of interstellar He originating from a hypothetic wave train in the Local Interstellar Cloud. A secondary population is expected from models, but the characteristics of the Warm Breeze do not fully conform to modeling results. If, nevertheless, this is the explanation, IBEX-Lo observations of the Warm Breeze provide key insights into the physical state of plasma in the outer heliosheath. If the second hypothesis is true, the source is likely to be located within a few thousand AU from the Sun, which is the propagation range of possible gusts of interstellar neutral helium with the Warm Breeze characteristics against dissipation via elastic scattering in the Local Cloud. Whatever the

  12. Idealized WRF model sensitivity simulations of sea breeze types and their effects on offshore windfields

    Directory of Open Access Journals (Sweden)

    C. J. Steele

    2013-01-01

    Full Text Available The behaviour and characteristics of the marine component of sea breeze cells have received little attention relative to their onshore counterparts. Yet there is a growing interest and dependence on the offshore wind climate from, for example, a wind energy perspective. Using idealized model experiments, we investigate the sea breeze circulation at scales which approximate to those of the southern North Sea, a region of major ongoing offshore wind farm development. We also contrast the scales and characteristics of the pure and the little known corkscrew and backdoor sea breeze types, where the type is pre-defined by the orientation of the synoptic scale flow relative to the shoreline. We find, crucially, that pure sea breezes, in contrast to corkscrew and backdoor types, can lead to substantial wind speed reductions offshore and that the addition of a second eastern coastline emphasises this effect through generation of offshore "calm zones". The offshore extent of all sea breeze types is found to be sensitive to both the influence of Coriolis acceleration and to the boundary layer scheme selected. These extents range, for example for a pure sea breeze produced in a 2 m s−1 offshore gradient wind, from 0 km to 21 km between the Mellor-Yamada-Nakanishi-Niino and the Yonsei State University schemes respectively. The corkscrew type restricts the development of a backdoor sea breeze on the opposite coast and is also capable of traversing a 100 km offshore domain even under high along-shore gradient wind speed (>15 m s−1 conditions. Realistic variations in sea surface skin temperature and initializing vertical thermodynamic profile do not significantly alter the resulting circulation, though the strengths of the simulated sea breezes are modulated if the effective land-sea thermal contrast is altered. We highlight how sea breeze impacts on circulation need to be

  13. WARM BREEZE FROM THE STARBOARD BOW: A NEW POPULATION OF NEUTRAL HELIUM IN THE HELIOSPHERE

    International Nuclear Information System (INIS)

    Kubiak, M. A.; Bzowski, M.; Sokół, J. M.; Swaczyna, P.; Grzedzielski, S.; Alexashov, D. B.; Izmodenov, V. V.; Möbius, E.; Leonard, T.; Fuselier, S. A.; McComas, D. J.; Wurz, P.

    2014-01-01

    We investigate the signals from neutral helium atoms observed in situ from Earth orbit in 2010 by the Interstellar Boundary Explorer (IBEX). The full helium signal observed during the 2010 observation season can be explained as a superposition of pristine neutral interstellar He gas and an additional population of neutral helium that we call the Warm Breeze. The Warm Breeze is approximately 2 times slower and 2.5 times warmer than the primary interstellar He population, and its density in front of the heliosphere is ∼7% that of the neutral interstellar helium. The inflow direction of the Warm Breeze differs by ∼19° from the inflow direction of interstellar gas. The Warm Breeze seems to be a long-term, perhaps permanent feature of the heliospheric environment. It has not been detected earlier because it is strongly ionized inside the heliosphere. This effect brings it below the threshold of detection via pickup ion and heliospheric backscatter glow observations, as well as by the direct sampling of GAS/Ulysses. We discuss possible sources for the Warm Breeze, including (1) the secondary population of interstellar helium, created via charge exchange and perhaps elastic scattering of neutral interstellar He atoms on interstellar He + ions in the outer heliosheath, or (2) a gust of interstellar He originating from a hypothetic wave train in the Local Interstellar Cloud. A secondary population is expected from models, but the characteristics of the Warm Breeze do not fully conform to modeling results. If, nevertheless, this is the explanation, IBEX-Lo observations of the Warm Breeze provide key insights into the physical state of plasma in the outer heliosheath. If the second hypothesis is true, the source is likely to be located within a few thousand AU from the Sun, which is the propagation range of possible gusts of interstellar neutral helium with the Warm Breeze characteristics against dissipation via elastic scattering in the Local Cloud. Whatever the nature

  14. Theory and Practice in the Context of Practicum: The Perspectives of Norwegian Physical Education Student Teachers

    Science.gov (United States)

    Standal, Øyvind Førland; Moen, Kjersti Mordal; Moe, Vegard Fusche

    2014-01-01

    Previous studies have found that student teachers value the practicum over other parts of physical education teacher education and that they experience a gap between theory and practice in their education. The purpose of this study was to provide more knowledge about the theory-practice relations in the context of the practicum of physical…

  15. Integrating Theory and Practice in the Pre-Service Teacher Education Practicum

    Science.gov (United States)

    Allen, Jeanne Maree; Wright, Suzie Elizabeth

    2014-01-01

    This article reports on a study into student teachers' perceptions about their professional development during practicum. Framed within a symbolic interactionist perspective, the study examined to what extent, and how effectively, one group of student teachers was able to integrate theory and practice during a three-week practicum in the first…

  16. The Effectiveness of an Embedded Approach to Practicum Experiences in Educational Leadership: Program Candidates' Perspectives

    Science.gov (United States)

    Chandler, Mary; Chan, Tak Cheung; Jiang, Binbin

    2013-01-01

    This study examined how effective an embedded practicum experience in an educational leadership program in a Southeastern University is in serving the purpose of preparing educational leaders to meet future challenges. Findings of this study confirm practicum areas that met the educational demands and highlight areas that need improvement to…

  17. Raising the Curtain: Investigating the Practicum Experiences of Pre-Service Drama Teachers

    Science.gov (United States)

    Gray, Christina C.; Wright, Peter R.; Pascoe, Robin

    2017-01-01

    The practicum is internationally recognised as a valuable component of teacher education. It is an opportunity for pre-service teachers to develop teaching skills in authentic ways and pursue professional inquiry into practice. While extensive research has been conducted into the practicum generally, little research focuses on the practicum…

  18. Early Childhood Practicum Students' Professional Growth in the USA: Areas of Confidence and Concern

    Science.gov (United States)

    Wee, Su-Jeong; Weber, Elsa K.; Park, Soyeon

    2014-01-01

    This research examines specific areas of confidence and concern as expressed by 40 American undergraduate early childhood students on a practicum (supervised field-based internships); if their beliefs changed over the course of their practicum, and if prior teaching experience had an impact on their confidence levels. Areas of confidence and…

  19. Research Practicum in Rehabilitation Counselor Education: Learning Research through Hands-on Experience

    Science.gov (United States)

    Miller, Susan M.; Rintelmann, Kristen

    2007-01-01

    The purpose of this paper is to discuss the research thesis as an educational tool and to propose the research practicum as an alternative to the thesis in rehabilitation counselor education programs. The research practicum has the potential to become an important learning opportunity which will provide rehabilitation counseling students with…

  20. Negotiating Contradictions in Developing Teacher Identity during the EAL Practicum in Australia

    Science.gov (United States)

    Nguyen, Minh Hue

    2017-01-01

    This paper reports on how Maria (pseudonym), a non-native English speaker (NNES) and preservice teacher (PST) of English as an additional language (EAL), developed her professional identity during the practicum in an Australian secondary school. Drawing on activity theory, the study identified contradictions in Maria's practicum activity and…

  1. Applying Kolb's Model to a Nontraditional Preservice Teaching Practicum

    Science.gov (United States)

    Burns, Amy; Danyluk, Patricia

    2017-01-01

    This article reports on the initial findings of an ongoing study that will see six preservice teachers placed in a nontraditional practicum placement as part of their bachelor of education program. Reported here is the examination of emergent professionalism of the initial two preservice teachers during their nontraditional practicum placement on…

  2. Developing Teaching Skills through the School Practicum in Turkey: A Metasynthesis Study

    Science.gov (United States)

    Tas, Mükerrem Akbulut; Karabay, Aysegül

    2016-01-01

    Using a metasynthesis approach, this study examined general teaching skills in previous studies on school practicum. The results and suggestions from 53 qualitative primary research studies that focused on school practicum in Turkey were reviewed. Data were collected using document analysis and content analysis using the NVivo10 programme. The…

  3. A Practicum Mentoring Model for Supporting Prospective Elementary Teachers in Learning to Teach Mathematics

    Science.gov (United States)

    Lin, Pi-Jen; Acosta-Tello, Enid

    2017-01-01

    The purpose of this study was to design and implement a practicum mentoring model to support prospective teachers as they learn to teach mathematics within a teacher education program. The context of this report on the practicum with an innovative mentoring model consisted of a pair of prospective teachers learning to teach mathematics from one…

  4. Examining the Practicum Experience to Increase Counseling Students' Self-Efficacy

    Science.gov (United States)

    Ikonomopoulos, James; Vela, Javier Cavazos; Smith, Wayne D.; Dell'Aquila, Julia

    2016-01-01

    Counseling graduate students may begin practicum with low self-efficacy regarding their counseling abilities and skills. In the current study, we implemented a small-series (N = 11) single-case research design to assess the effectiveness of the practicum experience to increase counseling students' self-efficacy. Analysis of participants' scores on…

  5. The Complexity of Practicum Assessment in Teacher Education: An Examination of Four New Zealand Case Studies

    Science.gov (United States)

    Aspden, Karyn M.

    2017-01-01

    Practicum is a key element of initial teacher education (ITE) programmes, designed to support the professional growth of student teachers. Practicum is also a key point of assessment, leading to a determination of the student's professional growth and their readiness to teach and enter the teaching profession. This study sought to understand the…

  6. A Database Practicum for Teaching Database Administration and Software Development at Regis University

    Science.gov (United States)

    Mason, Robert T.

    2013-01-01

    This research paper compares a database practicum at the Regis University College for Professional Studies (CPS) with technology oriented practicums at other universities. Successful andragogy for technology courses can motivate students to develop a genuine interest in the subject, share their knowledge with peers and can inspire students to…

  7. Mathematics Practicum at St. Olaf College: Project-Based Learning through Academic Civic Engagement

    Science.gov (United States)

    Sanft, Rebecca; Ziegler-Graham, Kathryn

    2018-01-01

    The Mathematics Practicum has been offered at St. Olaf College for over 30 years. The Practicum is a 4-week, January Interim course where three teams of five students work on consulting problems solicited from area businesses, government agencies, and non-profit organizations. These problems have significant mathematical, statistical, and…

  8. Treatment Option Overview (Melanoma)

    Science.gov (United States)

    ... Reporting & Auditing Grant Transfer Grant Closeout Contracts & Small Business Training Cancer Training at NCI (Intramural) Funding for ... the skin far away from where it first started. Recurrent Melanoma Recurrent melanoma is cancer that has ...

  9. General Information about Melanoma

    Science.gov (United States)

    ... Reporting & Auditing Grant Transfer Grant Closeout Contracts & Small Business Training Cancer Training at NCI (Intramural) Funding for ... the skin far away from where it first started. Recurrent Melanoma Recurrent melanoma is cancer that has ...

  10. Stages of Melanoma

    Science.gov (United States)

    ... Reporting & Auditing Grant Transfer Grant Closeout Contracts & Small Business Training Cancer Training at NCI (Intramural) Funding for ... the skin far away from where it first started. Recurrent Melanoma Recurrent melanoma is cancer that has ...

  11. Melanoma - neck (image)

    Science.gov (United States)

    This melanoma on the neck is variously colored with a very darkly pigmented area found centrally. It has irregular ... be larger than 0.5 cm. Prognosis in melanoma is best defined by its depth on resection.

  12. Primary ovarian malignant melanoma

    Directory of Open Access Journals (Sweden)

    Kostov Miloš

    2010-01-01

    Full Text Available Background. Primary ovarian malignant melanoma is extremely rare. It usually appears in the wall of a dermoid cyst or is associated with another teratomatous component. Metastatic primary malignant melanoma to ovary from a primary melanoma elsewhere is well known and has been often reported especially in autopsy studies. Case report. We presented a case of primary ovarian malignant melanoma in a 45- year old woman, with no evidence of extraovarian primary melanoma nor teratomatous component. The tumor was unilateral, macroscopically on section presented as solid mass, dark brown to black color. Microscopically, tumor cells showed positive immunohistochemical reaction for HMB-45, melan-A and S-100 protein, and negative immunoreactivity for estrogen and progesteron receptors. Conclusion. Differentiate metastatic melanoma from rare primary ovarian malignant melanoma, in some of cases may be a histopathological diagnostic problem. Histopathological diagnosis of primary ovarian malignant melanoma should be confirmed by immunohistochemical analyses and detailed clinical search for an occult primary tumor.

  13. Molecular Classification of Melanoma

    Science.gov (United States)

    Tissue-based analyses of precursors, melanoma tumors and metastases within existing study populations to further understanding of the heterogeneity of melanoma and determine a predictive pattern of progression for dysplastic nevi.

  14. Melanoma International Foundation

    Science.gov (United States)

    ... the state of Pennsylvania, certificate #29498 © 2013 Melanoma International Foundation. All Rights Reserved. Privacy Policy | Terms of Use Toll-free: 866-463-6663 International: 610-942-3432 Melanoma International Foundation 250 Mapleflower ...

  15. [Ocular melanomas : An update].

    Science.gov (United States)

    Kalirai, H; Müller, P L; Jaehne, D; Coupland, S E

    2017-11-01

    Melanoma is the most common type of primary cancer to affect the adult eye. Approximately 95% of ocular melanomas are intraocular and arise from the uvea (i. e. iris, ciliary body, and choroid), while the remaining 5% are located in the conjunctiva. Although both uveal and conjunctival melanomas are thought to derive from malignantly transformed melanocytes, uveal melanoma is clinically and biologically distinct from conjunctival melanoma, and indeed from its more common cutaneous counterpart. Intense efforts have been recently made to understand the molecular biology involved in the development of ocular melanomas, and in their progression. Molecular advances, particularly for uveal melanoma, have enhanced prognostication and the identification of rational therapeutic targets for disseminated disease. In this review, recent advances in the molecular characterisation of both uveal and conjunctival melanomas are discussed, and how these may be used to develop personalised therapeutic strategies.

  16. Drug effects on melanoma

    NARCIS (Netherlands)

    Koomen, Elsje Rosalie

    2010-01-01

    Cutaneous melanoma is the most aggressive form of skin cancer and its incidence among Caucasian populations has increased whereas mortality rates are stabilizing or decreasing. The total burden of melanoma is expected to be increasing. As effective treatment options for advanced melanoma are

  17. Burden of Melanoma

    NARCIS (Netherlands)

    C. Holterhues (Cynthia)

    2011-01-01

    markdownabstract__Abstract__ Melanoma is a type of skin cancer that arises from melanocytes. More than 95% of all melanomas occur in the skin, but rarely in the pigmented cells of the eye, meninges or mucosa. This thesis will only regard the invasive cutaneous malignant melanomas.

  18. Genetics of familial melanoma

    DEFF Research Database (Denmark)

    Aoude, Lauren G; Wadt, Karin A W; Pritchard, Antonia L

    2015-01-01

    Twenty years ago, the first familial melanoma susceptibility gene, CDKN2A, was identified. Two years later, another high-penetrance gene, CDK4, was found to be responsible for melanoma development in some families. Progress in identifying new familial melanoma genes was subsequently slow; however...

  19. Cutaneous melanoma in women

    Directory of Open Access Journals (Sweden)

    Mi Ryung Roh, MD

    2017-03-01

    Conclusions: The published findings on gender disparities in melanoma have yielded many advances in our understanding of this disease. Biological, environmental, and behavioral factors may explain the observed gender difference in melanoma incidence and outcome. Further research will enable us to learn more about melanoma pathogenesis, with the goal of offering better treatments and preventative advice to our patients.

  20. Cutaneous melanoma in women

    Directory of Open Access Journals (Sweden)

    Mi Ryung Roh, MD

    2015-02-01

    Conclusions: The published findings on gender disparities in melanoma have yielded many advances in our understanding of this disease. Biological, environmental, and behavioral factors may explain the observed gender difference in melanoma incidence and outcome. Further research will enable us to learn more about melanoma pathogenesis, with the goal of offering better treatments and preventative advice to our patients.

  1. The impact of land and sea surface variations on the Delaware sea breeze at local scales

    Science.gov (United States)

    Hughes, Christopher P.

    The summertime climate of coastal Delaware is greatly influenced by the intensity, frequency, and location of the local sea breeze circulation. Sea breeze induced changes in temperature, humidity, wind speed, and precipitation influence many aspects of Delaware's economy by affecting tourism, farming, air pollution density, energy usage, and the strength, and persistence of Delaware's wind resource. The sea breeze front can develop offshore or along the coastline and often creates a near surface thermal gradient in excess of 5°C. The purpose of this dissertation is to investigate the dynamics of the Delaware sea breeze with a focus on the immediate coastline using observed and modeled components, both at high resolutions (~200m). The Weather Research and Forecasting model (version 3.5) was employed over southern Delaware with 5 domains (4 levels of nesting), with resolutions ranging from 18km to 222m, for June 2013 to investigate the sensitivity of the sea breeze to land and sea surface variations. The land surface was modified in the model to improve the resolution, which led to the addition of land surface along the coastline and accounted for recent urban development. Nine-day composites of satellite sea surface temperatures were ingested into the model and an in-house SST forcing dataset was developed to account for spatial SST variation within the inland bays. Simulations, which include the modified land surface, introduce a distinct secondary atmospheric circulation across the coastline of Rehoboth Bay when synoptic offshore wind flow is weak. Model runs using high spatial- and temporal-resolution satellite sea surface temperatures over the ocean indicate that the sea breeze landfall time is sensitive to the SST when the circulation develops offshore. During the summer of 2013 a field campaign was conducted in the coastal locations of Rehoboth Beach, DE and Cape Henlopen, DE. At each location, a series of eleven small, autonomous thermo-sensors (i

  2. Changes in nearshore waves during the active sea/land breeze period off Vengurla, central west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Amrutha, M.M.; SanilKumar, V.; Singh, J.

    transformation. The wave height increased due to the sea breeze and reached its peak at ∼13:00 UTC at 15m water depth, whereas the peak significant wave height is at 12:00 UTC at 5m water depth. Due to the influence of the land/sea breeze system, the range...

  3. 78 FR 62300 - Prairie Breeze Wind Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing...

    Science.gov (United States)

    2013-10-15

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER14-25-000] Prairie Breeze Wind Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... Breeze Wind Energy LLC's application for market-based rate authority, with an accompanying rate schedule...

  4. PRE-SERVICE TEACHERS’ EXPERIENCES AT TEACHING PRACTICUM

    Directory of Open Access Journals (Sweden)

    Wakhid Nashruddin

    2015-07-01

    Full Text Available For many years, the teaching and learning English (as a foreign language in Indonesia has been considered unfruitful for students’ low ability in using the language in communication. For many times, government (as the leader of schools and campus (as teacher producer do not sit together to discuss this problem. This results to gaps between school and campus. I am interested in seeing this problem by viewing gaps occur in the process of campus preparing qualified English teachers. This paper will tell the result of my interviews with pre-service teachers about their experiences at teaching practicum program.

  5. Pre-Service Teachers’ Experiences at Teaching Practicum

    Directory of Open Access Journals (Sweden)

    Wakhid Nashruddin

    2015-07-01

    Full Text Available For many years, the teaching and learning English (as a foreign language in Indonesia has been considered unfruitful for students’ low ability in using the language in communication. For many times, government (as the leader of schools and campus (as teacher producer do not sit together to discuss this problem. This results to gaps between school and campus. I am interested in seeing this problem by viewing gaps occur in the process of campus preparing qualified English teachers. This paper will tell the result of my interviews with pre-service teachers about their experiences at teaching practicum program.

  6. The lake breeze-ground-level ozone connection in eastern Wisconsin: a climatological perspective

    Science.gov (United States)

    Lennartson, G. Jay; Schwartz, Mark D.

    2002-09-01

    The Lake Michigan Air Quality Region (LMAQR) experiences exceedances of the 1 h health standard for ozone numerous times each summer. Previous short-term investigations have revealed that the lake breeze circulation is connected with very high levels of ozone in eastern Wisconsin (EWI). Findings from one of the more recent short-term research efforts have led to the development of a generalized conceptual model that details the role that the lake breeze circulation plays in transporting ozone-rich air of the Lake Michigan conduction layer onshore to EWI. Short-term studies, however, are limited by the small number of cases examined. To understand the ozone-lake breeze relationship from a climatological perspective, we analysed the spatial and temporal pattern of 1 h ozone exceedances in EWI during the months of May through to September, over the period 1985-99. Further, we used Laird et al.'s recently developed technique for discriminating lake breeze days to determine which exceedance-days over the period of our climatology occurred in association with lake breezes.Our results show: (1) a decrease in both magnitude and frequency of exceedances of the 1 h ozone standard in EWI with increasing distance from the lakeshore; (2) a positive correlation between average onset time of the initial exceedance-hour and a site's distance from Lake Michigan; (3) a very high percentage of initial exceedance-hours occurring in association with southeasterly surface air flow; and (4) exceedances occurring in association with lake breezes 82.1% of the time at near-shore sites.Collectively, our findings provide strong evidence that the lake breeze circulation is closely associated with the distribution of ozone in EWI in both space and time. Moreover, our results show that the lake breeze circulation is directly associated with a significant proportion of the exceedances of the 1 h ozone standard in EWI-particularly at near-shore sites. Thus, mandated reductions in regional

  7. Tumor progression in uveal melanoma

    NARCIS (Netherlands)

    C.M. Mooij (Cornelia)

    1995-01-01

    textabstractOphthalmic melanomas can be divided in extra-ocular (conjunctiva, caruncle) and intraocular uveal melanomas (iris, ciliary body and choroid). Uveal melanomas account for 95% of ocular melanomas, while only 5% are conjunctival in origin. The extra-ocular and intra-ocular melanomas differ

  8. Virtual practicums within an MPH program: a career development case study.

    Science.gov (United States)

    Goodman, Jeffrey

    2015-01-01

    This article focuses on an innovative "virtual" practicum arrangement and provides insight for public health professionals seeking a meaningful practicum experience. The traditional practicum model where a student physically reports to work at the field site with a near full-time commitment has become increasingly challenging and often limiting in terms of field site choices and experiences available to a student depending on the location of a school and the student's area of interest. This is particularly true with students who are enrolled in a distance learning program. The experience obtained from a practicum is more important than ever before as rapid changes occur in health service delivery models as a result of the Patient Protection and Affordable Care Act. Career development through a practicum can be vitally important to a mid-career student seeking to remain relevant and in demand within a changing job market. To fulfill these needs, while still obtaining the benefits of a practicum, a virtual practicum arrangement could provide a solution. This case study provides practical tips based on the successful experience of a recent MPH graduate. © 2014 Society for Public Health Education.

  9. The effectiveness of separating theory and practicum as a conduit to learning physiology.

    Science.gov (United States)

    Schuijers, Johannes A; McDonald, Stuart J; Julien, Brianna L; Lexis, Louise A; Thomas, Colleen J; Chan, Siew; Samiric, T

    2013-06-01

    Many conventional science courses contain subjects embedded with laboratory-based activities. However, research on the benefits of positioning the practicals within the theory subject or developing them distinctly from the theory is largely absent. This report compared results in a physiology theory subject among three different cohorts of students: those taking the theory subject alone, those taking it concurrent with a physiology practicum subject, and those who previously took the subject when it had practicums embedded within the one subject. The path model shows that students taking both physiology theory and physiology practicum attained a significantly higher result in online tests compared with those who took the theory subject alone (P physiology theory and the physiology practicum attained a significantly higher end-examination result compared with those who took the physiology subject in previous years when the practicums were embedded within the theory subject (P physiology theory and the physiology practicum likely performed better in the theory subject due to better problem-solving skills and a more developed understanding of theoretical content. We suggest that consideration be given in all science curricula to the separation of theory and practicum by developing two subjects with clearly defined different learning outcomes.

  10. Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma

    Science.gov (United States)

    2016-05-06

    Acral Lentiginous Malignant Melanoma; Lentigo Maligna Malignant Melanoma; Nodular Malignant Melanoma; Recurrent Melanoma; Solar Radiation-related Skin Melanoma; Stage IV Melanoma; Superficial Spreading Malignant Melanoma

  11. Practicums as part of study programmes in library and information studies

    Directory of Open Access Journals (Sweden)

    Primož Južnič

    2016-11-01

    Full Text Available In Library and Information Science (LIS courses, practicums serve as a specific bond between theory on the one hand and practical work and the profession on the other. In seeking to prepare graduates for the profession and for professional work, LIS programmes use practicums as a model to enhance the library school curriculum. During the traditional LIS practicum, one already makes use of the many advantages online tools provide, building online portfolios or keeping student work diaries online while undertaking the practical part of one’s practicum. This enables easy and constant communication among all three stakeholders: host institutions, educational institutions, and students. Whilst it is important to engage actively with industry to provide students with opportunities to participate in ‘experiential learning’ and in building practical skills and knowledge, it is also important to ensure this is done in a systematic manner, and with a genuine desire on the part of the employers for a collaborative partnership. Striking similarities regarding practicums and placements between geographically distant countries such as Australia and Slovenia, and the opinions and attitudes that all three stakeholders – students, host institutions and educational institutions – share, indicates that traditional practicums, undertaken in a physical workplace, are still a key component of an LIS education.In Library and Information Science (LIS courses, practicums serve as a specific bond between theory onthe one hand and practical work and the profession on the other. In seeking to prepare graduates for theprofession and for professional work, LIS programmes use practicums as a model to enhance the libraryschool curriculum. During the traditional LIS practicum, one already makes use of the many advantagesonline tools provide, building online portfolios or keeping student work diaries online while undertakingthe practical part of one’s practicum. This

  12. Unveiling Pre-Service Teachers’ Attitudes Toward Teaching: The Role of Pedagogical Practicums

    Directory of Open Access Journals (Sweden)

    Yimer Andrés Morales Cortés

    2016-07-01

    Full Text Available This article reports a research developed at Universidad Pedagógica y Tecnológica de Colombia with a group of pre-service teachers that was immersed in an English teaching practicum. The main purpose of this inquiry was to find out the role that practicum exerted on novice teachers’ attitudes towards teaching. Data were collected through interviews, questionnaires, verbal reports, and artifacts. The results evidenced the English practicum provided the teachers being trained opportunities to consider what teaching entails. Thus, the participants were able to reflect, develop awareness, positive attitudes, and satisfaction towards their teaching practice.

  13. Air pollution studies in Chicago considering lake breeze events and land use

    Science.gov (United States)

    Schmeling, M.; Treering, D. J.

    2008-12-01

    Trace elemental, ionic species and reactive trace gases were monitored and measured in Chicago air during the summers of 2002 to 2005. Weather data obtained for the same time periods provided information about major wind patterns. Sampling times and duration were selected to coincide with lake breezes, which occur with highest frequency in summer. Lake breezes were observed between 14 and 47 percent of total collection days per summer and appeared to be more frequent in the cooler summers of 2003 and 2004. Depending on the predominant wind direction on the day before, pollutants increased briefly during a lake breeze event. On days without the occurrence of a lake breeze, it was found that the highest concentrations of pollutants were transported by southerly wind currents. Some major sources, such as brick and cement manufacturing, steel industry and heavy road traffic, lay in the path of this wind current. Chicago area land use and transportation maps were analyzed using a Geographic Information System (GIS) to identify major industrial complexes, intermodal terminals, highways and railroads. We also included demographic information in the GIS maps to analyze whether certain population groups are disproportionally exposed to air pollution. Our results will not only be interesting for the science community, but also to policy makers when considering air pollutant exposure and are expected to inform decisions regarding air pollution policy in the future.

  14. A numerical study of sea breeze circulation observed at a tropical ...

    Indian Academy of Sciences (India)

    A simulation study of the sea breeze circulation and thermal internal boundary layer (TIBL) characteristics has been carried out at the tropical site Kalpakkam on the east coast of India, for operational atmospheric dispersion prediction. The community based PSU/NCAR MM5 Mesoscale meteorological model is used for the ...

  15. Sea Breeze Forcing of Estuary Turbulence and Air-Water Exchanges

    Science.gov (United States)

    Orton, P. M.; McGillis, W. R.; Zappa, C. J.

    2010-12-01

    The sea breeze is often a dominant meteorological feature at the coastline, but little is known about its estuarine impacts. It arises on sunny days with weak synoptic weather forcing, due to O(100 km) scale atmospheric pressure differences that develop as a result of the different solar absorption properties of sea and land. Here, measurements at an anchored catamaran and meteorological stations along the Hudson River and New York Bay estuarine system are used to illustrate some basic characteristics and impacts of the feature. The sea breeze propagates inland, arriving in phase with peak solar forcing at seaward stations, but several hours later at up-estuary stations. Passage of the sea breeze front raises the water-to-air CO2 flux by 1-2 orders of magnitude, and drives turbulence comparable to spring tide levels in the upper meter of the water column, where most primary productivity occurs in this highly turbid system. Modeling and observational studies often use remotely-measured winds with quadratic parameterizations to compute air-water fluxes (e.g. momentum, CO2), and this leads to a factor of two flux error on sea breeze days during the study. We conclude with a survey of how common these features are in the Hudson as well as other estuaries.

  16. The Sea Breeze Convergence Zone and Its Relationship to Fair Weather Electricity in East Central Florida

    Science.gov (United States)

    1993-01-01

    and Rodebust 1948; Gentry and Moore 1954; Estoque 1962; Frank et al. 1967; Neumann 1971; Pielke 1974; Blanchard and Lopez 1985; Waston et al. 1987...convection and boundary layer interactions. J. Appl. Meteor., 21, 953-977. Estoque , M.A., 1962: The sea breeze as a function of the prevailing synoptic

  17. Impact of Bay-Breeze Circulations on Surface Air Quality and Boundary Layer Export

    Science.gov (United States)

    Loughner, Christopher P.; Tzortziou, Maria; Follette-Cook, Melanie; Pickering, Kenneth E.; Goldberg, Daniel; Satam, Chinmay; Weinheimer, Andrew; Crawford, James H.; Knapp, David J.; Montzka, Denise D.; hide

    2014-01-01

    Meteorological and air-quality model simulations are analyzed alongside observations to investigate the role of the Chesapeake Bay breeze on surface air quality, pollutant transport, and boundary layer venting. A case study was conducted to understand why a particular day was the only one during an 11-day ship-based field campaign on which surface ozone was not elevated in concentration over the Chesapeake Bay relative to the closest upwind site and why high ozone concentrations were observed aloft by in situ aircraft observations. Results show that southerly winds during the overnight and early-morning hours prevented the advection of air pollutants from the Washington, D.C., and Baltimore, Maryland, metropolitan areas over the surface waters of the bay. A strong and prolonged bay breeze developed during the late morning and early afternoon along the western coastline of the bay. The strength and duration of the bay breeze allowed pollutants to converge, resulting in high concentrations locally near the bay-breeze front within the Baltimore metropolitan area, where they were then lofted to the top of the planetary boundary layer (PBL). Near the top of the PBL, these pollutants were horizontally advected to a region with lower PBL heights, resulting in pollution transport out of the boundary layer and into the free troposphere. This elevated layer of air pollution aloft was transported downwind into New England by early the following morning where it likely mixed down to the surface, affecting air quality as the boundary layer grew.

  18. Land Breeze and Thermals: A Scale Threshold to Distinguish Their Effects

    Science.gov (United States)

    Yongqiang Liu

    2005-01-01

    Land breeze is a type of mesoscale circulation developed due to thermal forcing over a heterogeneous landscape. It can contribute to atmospheric dynamic and hydrologic processes through affecting heat and water fluxes on the land-atmosphere interface and generating shallow convective precipitation. If the scale of the landscape heterogeneity is smaller than a certain...

  19. Decoding Melanoma Metastasis

    Energy Technology Data Exchange (ETDEWEB)

    Damsky, William E. Jr. [Department of Dermatology, Yale School of Medicine, New Haven, Connecticut (United States); Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont (United States); Rosenbaum, Lara E.; Bosenberg, Marcus, E-mail: Marcus.Bosenberg@yale.edu [Department of Dermatology, Yale School of Medicine, New Haven, Connecticut (United States)

    2010-12-30

    Metastasis accounts for the vast majority of morbidity and mortality associated with melanoma. Evidence suggests melanoma has a predilection for metastasis to particular organs. Experimental analyses have begun to shed light on the mechanisms regulating melanoma metastasis and organ specificity, but these analyses are complicated by observations of metastatic dormancy and dissemination of melanocytes that are not yet fully malignant. Additionally, tumor extrinsic factors in the microenvironment, both at the site of the primary tumor and the site of metastasis, play important roles in mediating the metastatic process. As metastasis research moves forward, paradigms explaining melanoma metastasis as a step-wise process must also reflect the temporal complexity and heterogeneity in progression of this disease. Genetic drivers of melanoma as well as extrinsic regulators of disease spread, particularly those that mediate metastasis to specific organs, must also be incorporated into newer models of melanoma metastasis.

  20. Primary malignant melanoma

    Directory of Open Access Journals (Sweden)

    A. Ferhat Mısır

    2016-04-01

    Full Text Available Malignant melanomas (MM of the oral cavity are extremely rare, accounting for 0.2% to 8.0% of all malignant melanomas. Malignant melanomas is more frequently seen at the level of the hard palate and gingiva. Early diagnosis and treatment are important for reducing morbidity. Malignant melanoma cells stain positively with antibodies to human melanoma black 45, S-100 protein, and vimentin; therefore, immunohistochemistry can play an important role in evaluating the depth of invasion and the location of metastases. A 76-year-old man developed an oral malignant melanoma, which was originally diagnosed as a bluish reactive denture hyperplasia caused by an ill-fitting lower denture. The tumor was removed surgically, and histopathological examination revealed a nodular-type MM. There was no evidence of recurrence over a 4-year follow-up period.

  1. Bay breeze climatology at two sites along the Chesapeake bay from 1986-2010: Implications for surface ozone.

    Science.gov (United States)

    Stauffer, Ryan M; Thompson, Anne M

    Hourly surface meteorological measurements were coupled with surface ozone (O 3 ) mixing ratio measurements at Hampton, Virginia and Baltimore, Maryland, two sites along the Chesapeake Bay in the Mid-Atlantic United States, to examine the behavior of surface O 3 during bay breeze events and quantify the impact of the bay breeze on local O 3 pollution. Analyses were performed for the months of May through September for the years 1986 to 2010. The years were split into three groups to account for increasingly stringent environmental regulations that reduced regional emissions of nitrogen oxides (NO x ): 1986-1994, 1995-2002, and 2003-2010. Each day in the 25-year record was marked either as a bay breeze day, a non-bay breeze day, or a rainy/cloudy day based on the meteorological data. Mean eight hour (8-h) averaged surface O 3 values during bay breeze events were 3 to 5 parts per billion by volume (ppbv) higher at Hampton and Baltimore than on non-bay breeze days in all year periods. Anomalies from mean surface O 3 were highest in the afternoon at both sites during bay breeze days in the 2003-2010 study period. In conjunction with an overall lowering of baseline O 3 after the 1995-2002 period, the percentage of total exceedances of the Environmental Protection Agency (EPA) 75 ppbv 8-h O 3 standard that occurred on bay breeze days increased at Hampton for 2003-2010, while remaining steady at Baltimore. These results suggest that bay breeze circulations are becoming more important to causing exceedance events at particular sites in the region, and support the hypothesis of Martins et al. (2012) that highly localized meteorology increasingly drives air quality events at Hampton.

  2. CASE REPORT: NODULAR MELANOMA

    Directory of Open Access Journals (Sweden)

    Tina Zupančič

    2015-05-01

    Full Text Available Nodular melanoma is a rare type of cutaneous melanoma with an increased risk of death. It often mimics benign cutaneous tumors and inflammatory lesions. It has pronounced vertical growth phase and greater thickness at the time of diagnosis which caries ominous prognostic value. Nodular melanoma quickly develops metastases which are often present before the disease is clinically recognised. Here, we report a case of nodular melanoma clinically mimicking seborrheic keratosis. Therapy and 36 months follow-up after primal excision are also presented.

  3. Profile of Students Uninterested in Practicum Class at Faculty of Engineering Universitas Negeri Surabaya

    Science.gov (United States)

    Munoto; Sondang, Meini; Satriana, FMS

    2018-04-01

    This study aims to determine the characteristics of students who were uninterested in attending practicum classes. This study applied naturalistic qualitative research methods using participatory observation and interviews. The data validity was ensured by triangulation, detailed description, length of observation time, as well as details and thorough observation. The data were analyzed using domain analysis and followed by conducting taxonomic, component, and thematic analyses. The results of the study indicate that faineant students show a negative behavior while attending laboratory practicums. They have a lack of motivation, effective interaction, and attention. The cognitive abilities vary from low to high. Other causes on how the aspects of the study were low were found as well, therefore improving those aspects allows students to raise their interest in practicum classes. The impact is to create well-skilled vocational teachers in conducting practicum classes in vocational schools and to make graduates better-prepared for the workforce.

  4. The John Milner Nutrition and Cancer Prevention Research Practicum | Division of Cancer Prevention

    Science.gov (United States)

    Attendee Testimonial Plenty of Food for Thought Served Up at the John Milner Nutrition and Cancer Prevention Research Practicum by Julia Tobacyk Media Folder: research_groupView the Testimonial (PDF, 790 KB) Date: March 12-16, 2018 |

  5. Photovoltaic at Hollywood and Desert Breeze Recreational Centers

    Energy Technology Data Exchange (ETDEWEB)

    Ammerman, Shane [Clark County Comprehensive Planning Department, NV (United States)

    2015-09-24

    Executive Summary Renewable Energy Initiatives for Clark County Parks and Recreation Solar Project DOE grant # DE-EE0003180 In accordance with the goals of the Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy for promoting solar energy as clean, carbon-free and cost-effective, the County believed that a recreational center was an ideal place to promote solar energy technologies to the public. This project included the construction of solar electricity generation facilities (40kW) at two Clark County facility sites, Desert Breeze Recreational Center and Hollywood Recreational Center, with educational kiosks and Green Boxes for classroom instruction. The major objectives and goals of this Solar Project include demonstration of state of the art technologies for the generation of electricity from solar technology and the creation of an informative and educational tool in regards to the benefits and process of generating alternative energy. Clark County partnered with Anne Johnson (design architect/consultant), Affiliated Engineers Inc. (AEI), Desert Research Institute (DRI), and Morse Electric. The latest photovoltaic technologies were used in the project to help create the greatest expected energy savings for60443 each recreational center. This coupled with the data created from the monitoring system will help Clark County and NREL further understand the real time outputs from the system. The educational portion created with AEI and DRI incorporates material for all ages with a focus on K - 12. The AEI component is an animated story telling the fundamentals of how sunlight is turned into electricity and DRI‘s creation of Solar Green Boxes brings environmental education into the classroom. In addition to the educational component for the public, the energy that is created through the photovoltaic system also translates into saved money and health benefits for the general public. This project has helped Clark County to further add to its own

  6. Mental health nursing practicum: Student and mentor perspectives on stress and satisfaction

    Directory of Open Access Journals (Sweden)

    Sandra Gelabert Vilella

    2014-07-01

    Full Text Available Nursing students begin to complete practicum experiences during their first year, increasing the number of applied credits as they progress toward degree completion. This contributes to integrating knowledge and skills from all of their courses and to obtaining the basic competencies of the nursing profession. It is also essential to identify the student’s sources of stress in order to provide strategies to confront them and diminish the potential consequences. Therefore, it is a priority to ascertain the perception of stress and the stressors. This study applied both quantitative and quality methods to achieve its objectives: to analyze the perception of stress and the stress-generating factors faced by third- and fourth-year nursing students during the mental health practicum, and to determine satisfaction with the new mental health practicum in a student survey and in a focus group of mentor nurses. Study results identified four major stress factors before students began the practicum: the difficulty of providing nursing care for the patient with a mental disorder, knowing how to react in an unfamiliar situation, lack of knowledge about mental health services, and the possibility of patient aggression. Only the latter remained as a stressor after the practicum was completed. Student satisfaction with the mental health practicum was highly positive. Mentor nurses were particularly satisfied with the changes in student follow-up and evaluation, emphasizing the importance of reflective practice and students’ self-management of their learning experience as set out by the European Higher Education Area.

  7. Effect of sea breeze circulation on aerosol mixing state and radiative properties in a desert setting

    Directory of Open Access Journals (Sweden)

    Y. Derimian

    2017-09-01

    Full Text Available Chemical composition, microphysical, and optical properties of atmospheric aerosol deep inland in the Negev Desert of Israel are found to be influenced by daily occurrences of sea breeze flow from the Mediterranean Sea. Abrupt increases in aerosol volume concentration and shifts of size distributions towards larger sizes, which are associated with increase in wind speed and atmospheric water content, were systematically recorded during the summertime at a distance of at least 80 km from the coast. Chemical imaging of aerosol samples showed an increased contribution of highly hygroscopic particles during the intrusion of the sea breeze. Besides a significant fraction of marine aerosols, the amount of internally mixed marine and mineral dust particles was also increased during the sea breeze period. The number fraction of marine and internally mixed particles during the sea breeze reached up to 88 % in the PM1–2. 5 and up to 62 % in the PM2. 5–10 size range. Additionally, numerous particles with residuals of liquid coating were observed by SEM/EDX analysis. Ca-rich dust particles that had reacted with anthropogenic nitrates were evidenced by Raman microspectroscopy. The resulting hygroscopic particles can deliquesce at very low relative humidity. Our observations suggest that aerosol hygroscopic growth in the Negev Desert is induced by the daily sea breeze arrival. The varying aerosol microphysical and optical characteristics perturb the solar and thermal infrared radiations. The changes in aerosol properties induced by the sea breeze, relative to the background situation, doubled the shortwave radiative cooling at the surface (from −10 to −20.5 W m−2 and increased by almost 3 times the warming of the atmosphere (from 5 to 14 W m−2, as evaluated for a case study. Given the important value of observed liquid coating of particles, we also examined the possible influence of the particle homogeneity assumption on the

  8. Effect of sea breeze circulation on aerosol mixing state and radiative properties in a desert setting

    Science.gov (United States)

    Derimian, Yevgeny; Choël, Marie; Rudich, Yinon; Deboudt, Karine; Dubovik, Oleg; Laskin, Alexander; Legrand, Michel; Damiri, Bahaiddin; Koren, Ilan; Unga, Florin; Moreau, Myriam; Andreae, Meinrat O.; Karnieli, Arnon

    2017-09-01

    Chemical composition, microphysical, and optical properties of atmospheric aerosol deep inland in the Negev Desert of Israel are found to be influenced by daily occurrences of sea breeze flow from the Mediterranean Sea. Abrupt increases in aerosol volume concentration and shifts of size distributions towards larger sizes, which are associated with increase in wind speed and atmospheric water content, were systematically recorded during the summertime at a distance of at least 80 km from the coast. Chemical imaging of aerosol samples showed an increased contribution of highly hygroscopic particles during the intrusion of the sea breeze. Besides a significant fraction of marine aerosols, the amount of internally mixed marine and mineral dust particles was also increased during the sea breeze period. The number fraction of marine and internally mixed particles during the sea breeze reached up to 88 % in the PM1-2. 5 and up to 62 % in the PM2. 5-10 size range. Additionally, numerous particles with residuals of liquid coating were observed by SEM/EDX analysis. Ca-rich dust particles that had reacted with anthropogenic nitrates were evidenced by Raman microspectroscopy. The resulting hygroscopic particles can deliquesce at very low relative humidity. Our observations suggest that aerosol hygroscopic growth in the Negev Desert is induced by the daily sea breeze arrival. The varying aerosol microphysical and optical characteristics perturb the solar and thermal infrared radiations. The changes in aerosol properties induced by the sea breeze, relative to the background situation, doubled the shortwave radiative cooling at the surface (from -10 to -20.5 W m-2) and increased by almost 3 times the warming of the atmosphere (from 5 to 14 W m-2), as evaluated for a case study. Given the important value of observed liquid coating of particles, we also examined the possible influence of the particle homogeneity assumption on the retrieval of aerosol microphysical characteristics

  9. A Coastal Bay Summer Breeze Study, Part 1: Results of the Quiberon 2006 Experimental Campaign

    Science.gov (United States)

    Mestayer, Patrice G.; Calmet, Isabelle; Herlédant, Olivier; Barré, Sophie; Piquet, Thibaud; Rosant, Jean-Michel

    2018-04-01

    The Quiberon 2006 experiment was launched to document the onset and development of land and sea breezes over a semi-circular coastal bay propitious to inshore sailing competitions. The measurements were taken during the 2 weeks of 16-28 June 2006. Micrometeorological variables were recorded at three shore sites around the bay using turbulence sensors on 10-30-m high masts, on four instrumented catamarans at selected sites within the bay, and at a fourth shore site with a Sodar. Synoptic data and local measurements are analyzed here from the point of view of both micrometeorologists and competition skippers, testing in particular the empirical rules of breeze veering and backing according to the wind direction with respect to the coastline orientation at the mesoscale (the quadrant theory). Our analysis focuses on the patterns of lower-altitude wind direction and speed around the bay and over the water basin, and the temporal variations during the periods of the breeze onset, establishment and thermal reinforcement. In offshore synoptic-flow conditions (quadrants 1 and 2), the clockwise rotation of the surface flow had a very large amplitude, reaching up to 360°. The breeze strength was negatively correlated to that of the synoptic wind speed. In conditions of onshore synoptic flow from the west (quadrant 3) at an angle to the mainland coast but perpendicular to the Quiberon peninsula, the rotation of the flow was backwards in the early morning and clockwise during the day with a moderate amplitude (40°-50°) around the synoptic wind direction. As the surface wind speed was much larger than the synoptic wind speed, such a case we have designated as a "synoptic breeze". The breeze onset was shown to fail several times under the influence of weak non-thermal events, e.g., the passage of an occluded front or clouds or an excess of convection. Finally, several local-scale influences of the complex coastal shape appeared in our measurements, e.g., wind fanning in the

  10. THE PRACTICUM: AN EXAMPLE OF CHANGES IN THE TEACHING AND LEARNING PROCESS IN THE EUROPEAN HIGHER EDUCATION SPACE.

    OpenAIRE

    Gavari Starkie, Elisa

    2007-01-01

    In this article I focus on changes in the roles of both students and teachers in the EHES. In particular, this article describes the experience at UNED, the largest university in Spain, of teaching the Practicum, a fl agship subject as a bridge between the present study plans and the future plans under the EHES. At UNED, the Practicum is organised on two levels: the first Practicum aims to develop the observation skills of education professionals; the second level aims to develop intervention...

  11. Staging of cutaneous melanoma

    NARCIS (Netherlands)

    P. Mohr (P.); A.M.M. Eggermont (Alexander); A. Hauschild (Axel); A. Buzaid (A.)

    2009-01-01

    textabstractThe American Joint Committee on Cancer (AJCC) staging of cutaneous melanoma is a continuously evolving system. The identification of increasingly more accurate prognostic factors has led to major changes in melanoma staging over the years, and the current system described in this review

  12. Canine oral melanoma.

    Science.gov (United States)

    Bergman, Philip J

    2007-05-01

    Melanoma is the most common oral malignancy in the dog. Oral and/or mucosal melanoma has been routinely considered an extremely malignant tumor with a high degree of local invasiveness and high metastatic propensity. Primary tumor size has been found to be extremely prognostic. The World Health Organization staging scheme for dogs with oral melanoma is based on size, with stage I = or = 4cm tumor and/or lymph node metastasis, and stage IV = distant metastasis. Median survival times for dogs with oral melanoma treated with surgery are approximately 17 to 18, 5 to 6, and 3 months with stage I, II, and III disease, respectively. Significant negative prognostic factors include stage, size, evidence of metastasis, and a variety of histologic criteria. Standardized treatments such as surgery, coarse-fractionation radiation therapy, and chemotherapy have afforded minimal to modest stage-dependent clinical benefits and death is usually due to systemic metastasis. Numerous immunotherapeutic strategies have been employed to date with limited clinical efficacy; however, the use of xenogeneic DNA vaccines may represent a leap forward in clinical efficacy. Oral melanoma is a spontaneous syngeneic cancer occurring in outbred, immunocompetent dogs and appears to be a more clinically faithful therapeutic model for human melanoma; further use of canine melanoma as a therapeutic model for human melanoma is strongly encouraged. In addition, the development of an expanded but clinically relevant staging system incorporating the aforementioned prognostic factors is also strongly encouraged.

  13. Uveal melanoma: estimating prognosis.

    Science.gov (United States)

    Kaliki, Swathi; Shields, Carol L; Shields, Jerry A

    2015-02-01

    Uveal melanoma is the most common primary malignant tumor of the eye in adults, predominantly found in Caucasians. Local tumor control of uveal melanoma is excellent, yet this malignancy is associated with relatively high mortality secondary to metastasis. Various clinical, histopathological, cytogenetic features and gene expression features help in estimating the prognosis of uveal melanoma. The clinical features associated with poor prognosis in patients with uveal melanoma include older age at presentation, male gender, larger tumor basal diameter and thickness, ciliary body location, diffuse tumor configuration, association with ocular/oculodermal melanocytosis, extraocular tumor extension, and advanced tumor staging by American Joint Committee on Cancer classification. Histopathological features suggestive of poor prognosis include epithelioid cell type, high mitotic activity, higher values of mean diameter of ten largest nucleoli, higher microvascular density, extravascular matrix patterns, tumor-infiltrating lymphocytes, tumor-infiltrating macrophages, higher expression of insulin-like growth factor-1 receptor, and higher expression of human leukocyte antigen Class I and II. Monosomy 3, 1p loss, 6q loss, and 8q and those classified as Class II by gene expression are predictive of poor prognosis of uveal melanoma. In this review, we discuss the prognostic factors of uveal melanoma. A database search was performed on PubMed, using the terms "uvea," "iris," "ciliary body," "choroid," "melanoma," "uveal melanoma" and "prognosis," "metastasis," "genetic testing," "gene expression profiling." Relevant English language articles were extracted, reviewed, and referenced appropriately.

  14. Uveal melanoma: Estimating prognosis

    Directory of Open Access Journals (Sweden)

    Swathi Kaliki

    2015-01-01

    Full Text Available Uveal melanoma is the most common primary malignant tumor of the eye in adults, predominantly found in Caucasians. Local tumor control of uveal melanoma is excellent, yet this malignancy is associated with relatively high mortality secondary to metastasis. Various clinical, histopathological, cytogenetic features and gene expression features help in estimating the prognosis of uveal melanoma. The clinical features associated with poor prognosis in patients with uveal melanoma include older age at presentation, male gender, larger tumor basal diameter and thickness, ciliary body location, diffuse tumor configuration, association with ocular/oculodermal melanocytosis, extraocular tumor extension, and advanced tumor staging by American Joint Committee on Cancer classification. Histopathological features suggestive of poor prognosis include epithelioid cell type, high mitotic activity, higher values of mean diameter of ten largest nucleoli, higher microvascular density, extravascular matrix patterns, tumor-infiltrating lymphocytes, tumor-infiltrating macrophages, higher expression of insulin-like growth factor-1 receptor, and higher expression of human leukocyte antigen Class I and II. Monosomy 3, 1p loss, 6q loss, and 8q and those classified as Class II by gene expression are predictive of poor prognosis of uveal melanoma. In this review, we discuss the prognostic factors of uveal melanoma. A database search was performed on PubMed, using the terms "uvea," "iris," "ciliary body," "choroid," "melanoma," "uveal melanoma" and "prognosis," "metastasis," "genetic testing," "gene expression profiling." Relevant English language articles were extracted, reviewed, and referenced appropriately.

  15. Bronchial malignant melanoma.

    Science.gov (United States)

    Weshler, Z; Sulkes, A; Kopolovitch, J; Leviatan, A; Shifrin, E

    1980-01-01

    We describe a case of malignant melanoma presenting initially as an endobronchial lesion located in the left main bronchus causing total atelectasis. This resolved with radiation therapy. Widespread metastases developed shortly thereafter. The differential diagnosis of primary and metastatic bronchial malignant melanoma is discussed. Other isolated case reports are reviewed.

  16. Melanoma do aparelho ungueal Nail apparatus melanoma

    Directory of Open Access Journals (Sweden)

    Ignez Regina dos Santos Muri Mendonça

    2004-10-01

    Full Text Available O melanoma do aparelho ungueal é apresentação relativamente rara dessa neoplasia, muitas vezes diagnosticada como nevo juncional, hematoma subungueal ou mesmo onicomicose. Esse fato leva a um atraso no diagnóstico e, conseqüentemente, na instituição da terapêutica específica, contribuindo para agravar o prognóstico de uma doença que por si só já é muito agressiva. Os autores relatam um caso de melanoma no primeiro quirodáctilo esquerdo de uma paciente negra com evolução de um ano, ressaltando a importância de avaliar certos critérios clínicos para obter o diagnóstico em fases mais precoces da doença.Nail apparatus melanoma is a rare presentation of melanoma and may be misdiagnosed as junctional nevus, subungual hematoma or onychomycosis. This fact often leads initially to inappropriate treatment and significant delays in appropriately managing such an aggressive disease. The authors report a case of melanoma on the left thumb of a black patient evolving for a year. Emphasis was placed on the importance of assessing certain clinical characteristics in order to reach an early diagnosis.

  17. Melanoma during pregnancy

    DEFF Research Database (Denmark)

    de Haan, Jorine; Lok, Christianne A; de Groot, Christianne J M

    2017-01-01

    The management of melanoma during pregnancy is challenging as maternal benefits and fetal risks need to be balanced. Here, we present an overview of the incidence, the demographic and clinical characteristics and the treatment modalities used. After analysis of obstetric, fetal and maternal outcome......, recommendations for clinical practice are provided. From the 'International Network on Cancer, Infertility and Pregnancy' database, pregnant patients with melanoma were identified and analysed. Sixty pregnancies were eligible for analysis. Fifty percent of the patients presented with advanced melanoma during...... pregnancy (14 stage III and 16 stage IV), and 27% were diagnosed with recurrent melanoma. Surgery was the main therapeutic strategy during pregnancy. Only four patients with advanced melanoma were treated during pregnancy with systemic therapy (n=1) or radiotherapy (n=3). Premature delivery was observed...

  18. The Impact of Synoptic-Scale Flow on Sea Breeze Front Propagation and Intensity at Eglin Air Force Base

    Science.gov (United States)

    2006-03-01

    Blanchard and Lopez 1985). Numerical ( Estoque 1962; Bechtold et al. 1991; Arritt 1993) and observational (Kingsmill 1995; Atkins and Wakimoto 1997...observation and numerical research suggest that the sea breeze evolves differently under the influence of a prevailing background synoptic flow ( Estoque 1962...penetration of the sea breeze are strongly modulated by the presence of a background flow. a. Model Studies Estoque (1962) was one of the first

  19. Cutaneous manifestations associated with melanoma.

    Science.gov (United States)

    Vyas, Ritva; Selph, Jacqueline; Gerstenblith, Meg R

    2016-06-01

    Melanoma is a malignancy most commonly arising from the skin; therefore, primary melanoma characteristics are usually the first cutaneous manifestations of melanoma. Cutaneous metastases, which can occur locally or diffusely, are important to detect in a timely manner as treatments for advanced melanoma that impact survival are now available. Melanoma can be associated with local or diffuse pigmentation changes, including depigmentation associated with the leukodermas and hyperpigmentation associated with diffuse melanosis cutis. The leukodermas occur frequently, illustrate the immunogenic nature of melanoma, and may impact prognosis. Paraneoplastic syndromes in association with melanoma are rare, though can occur. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. A climatological study of sea breeze clouds in the southeast of the Iberian Peninsula (Alicante, Spain)

    Energy Technology Data Exchange (ETDEWEB)

    Azorin-Molina, C. [Grupo de Climatologia, Universidad de Barcelona, Barcelona, Cataluna (Spain)]. E-mail: cazorin@ceam.es; Sanchez-Lorenzo, A. [Grupo de Climatologia, Universidad de Barcelona, Barcelona, Cataluna (Spain); Calbo, J. [Grupo de Fisica Ambiental, Universidad de Girona, Campus Montilivi, Cataluna (Spain)

    2009-01-15

    Sea breezes blow under anticyclonic weather types, weak surface pressure gradients, intense solar radiation and relatively cloud-free skies. Generally, total cloud cover must be less than 4/8 in order to cause a thermal and pressure difference between land and sea air which allows the development of this local wind circulation. However, many numerical and observational studies have analyzed the ability of sea breezes to generate clouds in the convective internal boundary layer and in the sea breeze convergence zone. Accordingly, the aim of this study is to statistically analyze the impact of sea breezes on cloud types in the convective internal boundary layer and in the sea breeze convergence zone. The study area is located in the southeast of the Iberian Peninsula (province of Alicante, Spain) and the survey corresponds to a 6-yr study period (2000-2005). This climatological study is mainly based on surface cloud observations at the Alicante-Ciudad Jardin station (central coastal plain) and on an extensive cloud observation field campaign at the Villena-Ciudad station (Prebetic mountain ranges) over a 3-yr study period (2003-2005). The results confirm the hypothesis that the effect of sea breezes on cloud genera is to increase the frequency of low (Stratus) and convective (Cumulus) clouds. Sea breezes trigger the formation of thunderstorm clouds (Cumulonimbus) at the sea breeze convergence zone, which also have a secondary impact on high-level (Cirrus, Cirrocumulus, Cirrostratus), medium-level (Altostratus, Altocumulus) and low-level clouds (Stratus, Stratocumulus, Nimbostratus) associated with the Cumulonimbus clouds (e.g., Cumulonimbus anvil). [Spanish] Las brisas marinas soplan bajo tipos de tiempo anticiclonicos, debiles gradientes de presion atmosferica, radiacion solar intensa y cielos practicamente despejados. Por lo general, la cobertura nubosa total debe ser inferior a 4/8 para que se genere un diferencial termico y de presion entre el aire sobre las

  1. Reducibility mill scale industrial waste via coke breeze at 850-950ºC

    Directory of Open Access Journals (Sweden)

    Gaballah N.M.

    2015-01-01

    Full Text Available Mill scale is a very attractive industrial waste due to its elevated iron content (about = 69.33% Fe besides being suiTab. for direct recycling to the blast furnace via sintering plant. In this paper the characteristics of raw materials and the briquettes produced from this mill scale were studied by different methods of analyses. The produced briquettes were reduced with different amounts of coke breeze at varying temperatures, and the reduction kinetics was determined. The activation energy of this reaction ≈ 61.5 kJ/mole for reduction of mill scale with coke breeze in the form of briquettes with 2% molasses where the chemical reaction interface model is applicable.

  2. Sea breeze-induced wind sea growth in the central west coast of India.

    Digital Repository Service at National Institute of Oceanography (India)

    Aboobacker, V.M.; Seemanth, M.; Samiksha, S.V.; Sudheesh, K.; Kerkar, J.; Vethamony, P.

    in reasonable temporal and spatial resolutions (Grell et al., 1994). Theoretical study and experimental verification of wind wave generation and evolution focus generally on ideal conditions of steady state and quiescent initial background, of which the ideal... the land-sea breeze circulation along the central west coast of India using the mesoscale model, MM5, which was developed by the Pennsylvania State University / National Centre for Atmospheric Research (PSU/NCAR). It provides fine details of winds...

  3. Investigation of sea-breeze convergence in Salento Peninsula (southeastern Italy)

    Science.gov (United States)

    Comin, Alcimoni Nelci; Miglietta, Mario Marcello; Rizza, Umberto; Acevedo, Otavio Costa; Degrazia, Gervasio Annes

    2015-06-01

    The frequency, the location and the characteristics of convective rainfall events induced by the convergence of different sea breeze systems on a Mediterranean peninsula (Salento, in southeastern Italy) are analyzed. Such events have been studied considering satellite/radar images and output fields from two Limited Area Models in the summer period of 2011-2013. A total of 20 days have been detected in which the precipitation due to sea-breeze convergence was clearly observed in satellite and radar images. The synoptic conditions associated with these events have been identified considering the averages of some relevant meteorological parameters in the selected days and the anomaly with respect to the climate. The presence of a cold trough in the central Mediterranean basin appears as a fundamental ingredient for the occurrence of sea breeze convergence and associated precipitation. High-resolution simulations with two state-of-art numerical models have revealed that both of them are generally able to simulate a convergence pattern correctly, apart from a couple of cases for each model. The higher rainfall amounts occur with weak synoptic wind, and weak-to-moderate values of Convective Available Potential Energy (CAPE). When the synoptic wind is of moderate intensity, the region of convergence moves toward the Adriatic coast for a prevailing southerly component, and toward the Ionian coast for a prevailing northerly component. On the opposite, the skin sea surface temperature is relatively uniform and the difference between the Ionian and the Adriatic Seas, surrounding the peninsula on the east and west side, is generally smaller than 1 K, having only a marginal effect on the sea breeze patterns. Similarly, the value of CAPE before the occurrence of rainfall has low prognostic value. The results shows that limited area models with a grid spacing of few km appear as appropriate tools for the simulation for such relatively small scale phenomena.

  4. Synoptic-Scale Influence on the Monterey Bay Sea-Breeze

    Science.gov (United States)

    1994-09-01

    circulation often dictate circulation development more than the direct forcing terms. Studies such as Estoque (1962) and Arritt (1993) have demonstrated...penetration of the circulation ( Estoque , 1962). Along the eastern portion of the East Pacific Anticyclone, the immediate inland areas receive intense daytime...Marine Inversion Layer off the Central California Coast: Mesoscale Conditions." Mon. Wea. Rev., 121, 335-351. Estoque , M.A., 1962: "The Sea Breeze as

  5. Characterization of melanoma associated spongiform scleropathy

    DEFF Research Database (Denmark)

    Alyahya, Ghassan Ayish Jabur; Heegaard, Steffen; Prause, J.U.

    2002-01-01

    ophthalmology, melanoma associated spongiform scleropathy (MASS), MASS, malignant uveal melanoma, sclera, ciliary body, choroid, histopathology......ophthalmology, melanoma associated spongiform scleropathy (MASS), MASS, malignant uveal melanoma, sclera, ciliary body, choroid, histopathology...

  6. Management of Melanoma Families

    Directory of Open Access Journals (Sweden)

    Wilma Bergman

    2010-04-01

    Full Text Available In this review we have aimed to focus on the clinical management of familial melanoma patients and their relatives. Along this line three major topics will be discussed: (1 management/screening of familial melanoma families: what is advised and what is the evidence thereof; (2 variability of families worldwide with regard to clinical phenotype, including cancer spectrum and likelihood of finding germline mutations and (3 background information for clinicians on the molecular biology of familial melanoma and recent developments in this field.

  7. Mechanical strength of extrusion briquettes (BREX) for blast-furnace and ferroalloy production: II. Effect of the method of grinding coke breeze on the strength of extrusion briquettes

    Science.gov (United States)

    Bizhanov, A. M.; Kurunov, I. F.; Dashevskii, V. Ya.

    2015-05-01

    The influence of the method of grinding coke breeze on the strength and the behavior of extrusion briquette (BREX) during static loading is studied. It is found that the size, the shape, and the surface relief of coke breeze particles affect the character of BREX fracture. The application of a shearing extruder for preliminary refinement of coke breeze can result in viscoelastic fracture of BREX due to an increase in its impact toughness.

  8. Information technologies at physics practicums in a subject-oriented school

    Directory of Open Access Journals (Sweden)

    Tishchenko Lyudmila V.

    2016-01-01

    Full Text Available The paper suggests a new method of implementing an activity approach in a physicsoriented program. Such method implies the use of a system which comprises three types of practical sessions: a laboratory practicum, a practical training aimed at analyzing physical processes on the basis of computerized modeling and a problem-solving practicum. A methodology used for holding practicums provides for an active use of information technologies. At laboratory sessions we use computerized sensors, tablets with an integrated data recorder, an electronic oscilloscope and process data in Excel tables. At practicums aimed at analyzing physical processes, we develop programs in Visual Basic and Рascal in order to visualize physical processes in the form of motion trajectories, dynamic charts; besides, we conduct computer experiments. At problem-solving practicums we use our own PowerPoint “Study Guide for an Interactive Whiteboard”, which contains a database of graphic and pictorial physics problems for students of 10–11 grades. Knowledge of information technologies facilitates students’ adaptation in modern society, improves education quality.

  9. Student perceptions of a hands-on practicum to supplement an online eHealth course.

    Science.gov (United States)

    Edirippulige, Sisira; Smith, Anthony C; Armfield, Nigel R; Bensink, Mark; Wootton, Richard

    2012-12-18

    Since 2000, the Centre for Online Health (COH) at The University of Queensland has offered a range of online eHealth courses at the undergraduate and postgraduate level. While online learning has a number of advantages, in some domains, it can present some challenges to the development of practical skills and experience. To assess students' perceptions of the value of an eHealth practicum. To supplement our online learning program, we introduced an eHealth practicum component that aimed to expose students to a range of clinically relevant learning experiences. Subsequently, by means of a questionnaire, student perceptions of the practicum were assessed. Over two semesters, a total of 66 students participated in the eHealth practicum, and questionnaire responses were very positive. The majority of students agreed that the practicum allowed them to gain necessary skills in eHealth applications (59%) and provided them with an opportunity to explore ways of using different eHealth tools for the delivery of health care at a distance (62%). The study shows that a practical component in eHealth teaching was well received by students. While online teaching is appropriate for providing knowledge, the opportunity to develop practical skills may encourage students to use eHealth techniques in their future practices.

  10. Intravital Microscopy for Identifying Tumor Vessels in Patients With Stage IA-IV Melanoma That is Being Removed by Surgery

    Science.gov (United States)

    2017-06-05

    Recurrent Melanoma; Stage IA Skin Melanoma; Stage IB Skin Melanoma; Stage IIA Skin Melanoma; Stage IIB Skin Melanoma; Stage IIC Skin Melanoma; Stage IIIA Skin Melanoma; Stage IIIB Skin Melanoma; Stage IIIC Skin Melanoma; Stage IV Skin Melanoma

  11. Student Responses to an ICT-Based E-Assessment Application for the Teaching Practicum/Teaching Practice MODULE

    Science.gov (United States)

    Davids, M. Noor

    2017-01-01

    Situated within the context of Initial Teacher Education (ITE) in South Africa, this study introduces the notion of an interactive Teaching Practicum E- Assessment application: e-assessment application for the teaching practicum/Teaching Practice module to replace the current model of assessment. At present students enrolled for an Initial Teacher…

  12. The Danish Melanoma Database

    DEFF Research Database (Denmark)

    Hölmich, Lisbet Rosenkrantz; Klausen, Siri; Spaun, Eva

    2016-01-01

    AIM OF DATABASE: The aim of the database is to monitor and improve the treatment and survival of melanoma patients. STUDY POPULATION: All Danish patients with cutaneous melanoma and in situ melanomas must be registered in the Danish Melanoma Database (DMD). In 2014, 2,525 patients with invasive......-node-metastasis stage. Information about the date of diagnosis, treatment, type of surgery, including safety margins, results of lymphoscintigraphy in patients for whom this was indicated (tumors > T1a), results of sentinel node biopsy, pathological evaluation hereof, and follow-up information, including recurrence......, nature, and treatment hereof is registered. In case of death, the cause and date are included. Currently, all data are entered manually; however, data catchment from the existing registries is planned to be included shortly. DESCRIPTIVE DATA: The DMD is an old research database, but new as a clinical...

  13. Proteomics in uveal melanoma.

    LENUS (Irish Health Repository)

    Ramasamy, Pathma

    2014-01-01

    Uveal melanoma is the most common primary intraocular malignancy in adults, with an incidence of 5-7 per million per year. It is associated with the development of metastasis in about 50% of cases, and 40% of patients with uveal melanoma die of metastatic disease despite successful treatment of the primary tumour. The survival rates at 5, 10 and 15 years are 65%, 50% and 45% respectively. Unlike progress made in many other areas of cancer, uveal melanoma is still poorly understood and survival rates have remained similar over the past 25 years. Recently, advances made in molecular genetics have improved our understanding of this disease and stratification of patients into low risk and high risk for developing metastasis. However, only a limited number of studies have been performed using proteomic methods. This review will give an overview of various proteomic technologies currently employed in life sciences research, and discuss proteomic studies of uveal melanoma.

  14. Primary leptomeningeal melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Aichner, F.; Schuler, G.

    1982-11-01

    A case of primary leptomeningeal melanoma is presented in which the diagnosis was made by ultrastructural demonstration of melanoma cells from the cerebrospinal fluid (CSF) at a time when cranial computed tomography (CT) still gave negative results. Later CT examinations documented the emergence of a tumor mass of the left temporoparietal lobe. This case clearly illustrates the complementary role of these investigational procedures for the diagnosis of cerebrospinal melanoma: leptomeningeal involvement, characterized by two-dimensional diffuse spread of melanoma tissue (''leptomeningeal melanomatosis''), is invisible with CT, but easily recognisable by CSF cytology; in contrast, nodular parenchymal tumor deposits can be readily detected by CT. Identification of pigmented cells recovered from the CSF requires ultrastructural confirmation.

  15. Primary Anorectal Melanoma: An Update

    Directory of Open Access Journals (Sweden)

    P Carcoforo, M.T Raiji, G.M Palini, M Pedriali, U Maestroni, G Soliani, A Detroia, M.V Zanzi, A.L Manna, J.G Crompton, R.C Langan, A Stojadinovic, I Avital

    2012-01-01

    Full Text Available The anorectum is a rare anatomic location for primary melanoma. Mucosal melanoma is a distinct biological and clinical entity from the more common cutaneous melanoma. It portrays worse prognosis than cutaneous melanoma, with distant metastases being the overwhelming cause of morbidity and mortality. Surgery is the treatment of choice, but significant controversy exists over the extent of surgical resection. We present an update on the state of the art of anorectal mucosal melanoma. To illustrate the multimodality approach to anorectal melanoma, we present a typical patient.

  16. Genetics of Melanoma

    Directory of Open Access Journals (Sweden)

    Janet eWangari-Talbot

    2013-01-01

    Full Text Available Genomic variation is a trend observed in various human diseases including cancer. Genetic studies have set out to understand how and why these variations result in cancer, why some populations are predisposed to the disease, and also how genetics affect drug responses. The melanoma incidence has been increasing at an alarming rate worldwide. The burden posed by melanoma has made it a necessity to understand the fundamental signaling pathways involved in this deadly disease. Signaling cascades such as MAPK and PI3K/AKT have been shown to be crucial in the regulation of processes that are commonly dysregulated during cancer development such as aberrant proliferation, loss of cell cycle control, impaired apoptosis and altered drug metabolism. Understanding how these and other oncogenic pathways are regulated has been integral in our challenge to develop potent anti-melanoma drugs. With advances in technology and especially in next generation sequencing, we have been able to explore melanoma genomes and exomes leading to the identification of previously unknown genes with functions in melanomagenesis such as GRIN2A and PREX2. The therapeutic potential of these novel candidate genes is actively being pursued with some presenting as druggable targets while others serve as indicators of therapeutic responses. In addition, the analysis of the mutational signatures of melanoma tumors continues to cement the causative role of UV exposure in melanoma pathogenesis. It has become distinctly clear that melanomas from sun exposed skin areas have distinct mutational signatures including C to T transitions indicative of UV-induced damage. It is thus necessary to continue spreading awareness on how to decrease the risk factors of developing the disease while at the same time working for a cure. Given the large amount of information gained from these sequencing studies, it is likely that in the future, treatment of melanoma will follow a highly personalized route

  17. Perforating metastatic melanoma

    Directory of Open Access Journals (Sweden)

    Takenobu Ohashi

    2015-01-01

    Full Text Available We describe a case of metastatic malignant melanoma on the thigh with comedo-like appearance, which histologically showed elimination of tumor cells. A 70 year-old man was diagnosed with a nodular type malignant melanoma involving the lower back with satellite lesions (stage IIIB, T4b N2c M0, Breslow’s tumor thickness; 10.3 mm, Clark’s level; IV.

  18. Disseminated malignant melanoma

    Directory of Open Access Journals (Sweden)

    Verma Kaushal

    1999-01-01

    Full Text Available A 25-year-old man had multiple asymptomatic, nodular lesions on the trunk, extremities and the face for 3 months. He also had left facial palsy with severe headache and vomiting. There were no other systemic or constitutional symptoms. Skin biopsy from a nodular lesion showed features of malignant melanoma, confirmed by Fontana Masson and S-100 protein staining. A diagnosis of disseminated malignant melanoma was made and the patient was treated symptomatically. The patient died in 4 months.

  19. Radioimmunoscintigraphy in ocular melanoma

    International Nuclear Information System (INIS)

    Kovacs, J.; Chatterton, B.E.; Muecke, J.; Penglis, S.

    1999-01-01

    Full text: Malignant choroidal melanoma is one of the most common primary intraocular neoplasms. Despite significant advances in indirect ophthalmology, ultrasound, computed tomography (CT), magnetic resonance imaging (MRI) and fluoroescein angiography, choroidal melanomas may be difficult to distinguish from other malignant and non-malignant eye lesions. Radioimmunoscintigraphy (RIS) with 99 Tc m -labelled monoclonal antibody F(ab')2 fragments was performed on three patients (2 females, 1 male) who were suspected of having a choroidal melanoma. Patients were injected with 240-420 MBq Technemab-K-1 and scanned 6 and 22 h post-injection. Both planar and single photon emission tomographic (SPET) imaging were performed. RIS was faintly positive in one patient in whom the diagnosis of choroidal melanoma was confirmed by enucleation of the left eye. In the other two patients, immunoscintigraphy was negative. One patient had a benign choroidal haemangioma and the other an amelanotic melanoma. This was confirmed on clinical follow-up. These preliminary results indicate that this procedure may have utility for choroidal melanoma

  20. Genetic algorithm to solve the problems of lectures and practicums scheduling

    Science.gov (United States)

    Syahputra, M. F.; Apriani, R.; Sawaluddin; Abdullah, D.; Albra, W.; Heikal, M.; Abdurrahman, A.; Khaddafi, M.

    2018-02-01

    Generally, the scheduling process is done manually. However, this method has a low accuracy level, along with possibilities that a scheduled process collides with another scheduled process. When doing theory class and practicum timetable scheduling process, there are numerous problems, such as lecturer teaching schedule collision, schedule collision with another schedule, practicum lesson schedules that collides with theory class, and the number of classrooms available. In this research, genetic algorithm is implemented to perform theory class and practicum timetable scheduling process. The algorithm will be used to process the data containing lists of lecturers, courses, and class rooms, obtained from information technology department at University of Sumatera Utara. The result of scheduling process using genetic algorithm is the most optimal timetable that conforms to available time slots, class rooms, courses, and lecturer schedules.

  1. Changes in nearshore waves during the active sea/land breeze period off Vengurla, central west coast of India

    Directory of Open Access Journals (Sweden)

    M. M. Amrutha

    2016-02-01

    Full Text Available A unique feature observed in the tropical and subtropical coastal area is the diurnal sea-breeze/land-breeze cycle. We examined the nearshore waves at 5 and 15 m water depth during the active sea/land breeze period (January–April in the year 2015 based on the data measured using the waverider buoys moored in the eastern Arabian sea off Vengurla, central west coast of India. Temporal variability of diurnal wave response is examined. Numerical model Delft3D is used to study the nearshore wave transformation. The wave height increased due to the sea breeze and reached its peak at  ∼ 13:00 UTC at 15 m water depth, whereas the peak significant wave height is at 12:00 UTC at 5 m water depth. Due to the influence of the land/sea breeze system, the range of the peak wave period in 1 day varied up to 8 s. Reduction in the wave height of wind-sea is around 20 % and that of the swell is around 10 % from 15 to 5 m water depth.

  2. The Danish Melanoma Database

    Directory of Open Access Journals (Sweden)

    Hölmich Lr

    2016-10-01

    Full Text Available Lisbet Rosenkrantz Hölmich,1 Siri Klausen,2 Eva Spaun,3 Grethe Schmidt,4 Dorte Gad,5 Inge Marie Svane,6,7 Henrik Schmidt,8 Henrik Frank Lorentzen,9 Else Helene Ibfelt10 1Department of Plastic Surgery, 2Department of Pathology, Herlev-Gentofte Hospital, University of Copenhagen, Herlev, 3Institute of Pathology, Aarhus University Hospital, Aarhus, 4Department of Plastic and Reconstructive Surgery, Breast Surgery and Burns, Rigshospitalet – Glostrup, University of Copenhagen, Copenhagen, 5Department of Plastic Surgery, Odense University Hospital, Odense, 6Center for Cancer Immune Therapy, Department of Hematology, 7Department of Oncology, Herlev-Gentofte Hospital, University of Copenhagen, Herlev, 8Department of Oncology, 9Department of Dermatology, Aarhus University Hospital, Aarhus, 10Registry Support Centre (East – Epidemiology and Biostatistics, Research Centre for Prevention and Health, Glostrup – Rigshospitalet, University of Copenhagen, Glostrup, Denmark Aim of database: The aim of the database is to monitor and improve the treatment and survival of melanoma patients.Study population: All Danish patients with cutaneous melanoma and in situ melanomas must be registered in the Danish Melanoma Database (DMD. In 2014, 2,525 patients with invasive melanoma and 780 with in situ tumors were registered. The coverage is currently 93% compared with the Danish Pathology Register.Main variables: The main variables include demographic, clinical, and pathological characteristics, including Breslow’s tumor thickness, ± ulceration, mitoses, and tumor–node–metastasis stage. Information about the date of diagnosis, treatment, type of surgery, including safety margins, results of lymphoscintigraphy in patients for whom this was indicated (tumors > T1a, results of sentinel node biopsy, pathological evaluation hereof, and follow-up information, including recurrence, nature, and treatment hereof is registered. In case of death, the cause and date

  3. Treatment Options by Stage (Melanoma)

    Science.gov (United States)

    ... Reporting & Auditing Grant Transfer Grant Closeout Contracts & Small Business Training Cancer Training at NCI (Intramural) Funding for ... the skin far away from where it first started. Recurrent Melanoma Recurrent melanoma is cancer that has ...

  4. Intracerebral metastases from ocular melanoma.

    OpenAIRE

    Jones, D. R.; Scobie, I. N.; Sarkies, N. J.

    1988-01-01

    A blind painful eye may harbour an unsuspected malignant melanoma. We report a case of ocular melanoma that presented with confusion owing to direct extension via the optic nerve into the anterior cranial fossa.

  5. TAPIOCA MELANOMA OF THE IRIS

    NARCIS (Netherlands)

    DEKEIZER, RJW; OOSTERHUIS, JA; HOUTMAN, WA; DEWOLFFROUENDAAL, D

    Clinical identification of tapioca melanoma of the iris is important because its medical treatment may differ from that of other malignant iris melanomas. The characteristic iris nodules must be differentiated from granulomatous uveitis, metastases, and Lisch nodules (neurofibromatosis). We will

  6. Advanced Melanoma Facebook Live Event

    Science.gov (United States)

    In case you missed it, watch this recent Facebook Live event about the current state of research and treatment for advanced stage melanoma. To learn more, see our evidence-based information about skin cancer, including melanoma.

  7. The Amazon river breeze and the local boundary layer. I - Observations

    Science.gov (United States)

    De Oliveira, Amauri P.; Fitzjarrald, David R.

    1993-01-01

    Observations of the diurnal evolution of the planetary boundary layer over the Amazon rain forest, made at sites close to the confluence of the Solimoes and Negro rivers (approximately at 3 deg S, 60 deg W) near Manaus, Amazonas, Brazil, show the existence of a diurnal rotation of the wind near the surface and the frequent presence of low-level nocturnal wind maxima. These circulations are shown to be plausibly explained as elements of a river and land breeze circulation induced by the thermal contrast between the rivers and the adjacent forest.

  8. The Amazon river breeze and the local boundary layer: I. Observations

    Science.gov (United States)

    Pereira Oliveira, Amauri; Fitzjarrald, David R.

    1993-02-01

    Observations of the diurnal evolution of the planetary boundary layer over the Amazon rain forest, made at sites close to the confluence of the Solimões and Negro rivers (approximately at 3°S, 60°W) near Manaus, Amazonas, Brazil, show the existence of a diurnal rotation of the wind near the surface and the frequent presence of low-level nocturnal wind maxima. These circulations are shown to be plausibly explained as elements of a river and land breeze circulation induced by the thermal contrast between the rivers and the adjacent forest.

  9. Nearshore circulation on a sea breeze dominated beach during intense wind events

    Science.gov (United States)

    Torres-Freyermuth, Alec; Puleo, Jack A.; DiCosmo, Nick; Allende-Arandía, Ma. Eugenia; Chardón-Maldonado, Patricia; López, José; Figueroa-Espinoza, Bernardo; de Alegria-Arzaburu, Amaia Ruiz; Figlus, Jens; Roberts Briggs, Tiffany M.; de la Roza, Jacobo; Candela, Julio

    2017-12-01

    A field experiment was conducted on the northern Yucatan coast from April 1 to April 12, 2014 to investigate the role of intense wind events on coastal circulation from the inner shelf to the swash zone. The study area is characterized by a micro-tidal environment, low-energy wave conditions, and a wide and shallow continental shelf. Furthermore, easterly trade winds, local breezes, and synoptic-scale events, associated with the passage of cold-fronts known as Nortes, are ubiquitous in this region. Currents were measured concurrently at different cross-shore locations during both local and synoptic-scale intense wind events to investigate the influence of different forcing mechanisms (i.e., large-scale currents, winds, tides, and waves) on the nearshore circulation. Field observations revealed that nearshore circulation across the shelf is predominantly alongshore-directed (westward) during intense winds. However, the mechanisms responsible for driving instantaneous spatial and temporal current variability depend on the weather conditions and the across-shelf location. During local strong sea breeze events (W > 10 m s-1 from the NE) occurring during spring tide, westward circulation is controlled by the tides, wind, and waves at the inner-shelf, shallow waters, and inside the surf/swash zone, respectively. The nearshore circulation is relaxed during intense land breeze events (W ≈ 9 m s-1 from the SE) associated with the low atmospheric pressure system that preceded a Norte event. During the Norte event (Wmax≈ 15 m s-1 from the NNW), westward circulation dominated outside the surf zone and was correlated to the Yucatan Current, whereas wave breaking forces eastward currents inside the surf/swash zone. The latter finding implies the existence of large alongshore velocity shear at the offshore edge of the surf zone during the Norte event, which enhances mixing between the surf zone and the inner shelf. These findings suggest that both sea breezes and Nortes play

  10. ORAL AMELANOTIC MELANOMA FEATURE ARTICLE

    African Journals Online (AJOL)

    hard palate (more than 40%) and the gingiva2. Melanomas arise from the uninhibited proliferation ... Malignant melanomas of the mucosal regions of the head and neck are extremely rare neoplasms accounting for less than 1% of .... head and neck region reported that amelanotic melanomas had a 20% survival at 3 years, ...

  11. Genetic Abnormalities in Uveal Melanoma

    NARCIS (Netherlands)

    N.C. Naus (Nicole)

    2001-01-01

    textabstractMelanocytic tumours are believed to arise from the neural crest-derived melanocytes. Five to twelve percent of all melanomas are located in the eye, making it, after the skin, the second most common site of melanomas (Egan et al., 1988; Chang et al., 1998). Uveal melanoma is the most

  12. Targeted Therapy for Melanoma

    International Nuclear Information System (INIS)

    Quinn, Thomas; Moore, Herbert

    2016-01-01

    The research project, entitled ''Targeted Therapy for Melanoma,'' was focused on investigating the use of kidney protection measures to lower the non-specific kidney uptake of the radiolabeled Pb-DOTA-ReCCMSH peptide. Previous published work demonstrated that the kidney exhibited the highest non-target tissue uptake of the 212Pb/203 Pb radiolabeled melanoma targeting peptide DOTA-ReCCMSH. The radiolabeled alpha-melanocyte stimulating hormone (α-MSH) peptide analog DOTA-Re(Arg 11 )CCMSH, which binds the melanocortin-1 receptor over-expressed on melanoma tumor cells, has shown promise as a PRRT agent in pre-clinical studies. High tumor uptake of 212 Pb labeled DOTA-Re(Arg 11 )CCMSH resulted in tumor reduction or eradication in melanoma therapy studies. Of particular note was the 20-50% cure rate observed when melanoma mice were treated with alpha particle emitter 212 Pb. However, as with most PRRT agents, high radiation doses to the kidneys where observed. To optimize tumor treatment efficacy and reduce nephrotoxicity, the tumor to kidney uptake ratio must be improved. Strategies to reduce kidney retention of the radiolabeled peptide, while not effecting tumor uptake and retention, can be broken into several categories including modification of the targeting peptide sequence and reducing proximal tubule reabsorption.

  13. Targeted Therapy for Melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Quinn, Thomas [Alphamed, Jackson, TN (United States); Moore, Herbert [Alphamed, Jackson, TN (United States)

    2016-12-05

    The research project, entitled ”Targeted Therapy for Melanoma,” was focused on investigating the use of kidney protection measures to lower the non-specific kidney uptake of the radiolabeled Pb-DOTA-ReCCMSH peptide. Previous published work demonstrated that the kidney exhibited the highest non-target tissue uptake of the 212Pb/203Pb radiolabeled melanoma targeting peptide DOTA-ReCCMSH. The radiolabeled alpha-melanocyte stimulating hormone (α-MSH) peptide analog DOTA-Re(Arg11)CCMSH, which binds the melanocortin-1 receptor over-expressed on melanoma tumor cells, has shown promise as a PRRT agent in pre-clinical studies. High tumor uptake of 212Pb labeled DOTA-Re(Arg11)CCMSH resulted in tumor reduction or eradication in melanoma therapy studies. Of particular note was the 20-50% cure rate observed when melanoma mice were treated with alpha particle emitter 212Pb. However, as with most PRRT agents, high radiation doses to the kidneys where observed. To optimize tumor treatment efficacy and reduce nephrotoxicity, the tumor to kidney uptake ratio must be improved. Strategies to reduce kidney retention of the radiolabeled peptide, while not effecting tumor uptake and retention, can be broken into several categories including modification of the targeting peptide sequence and reducing proximal tubule reabsorption.

  14. Theoretical calculations of interactions between urban breezes and mountain slope winds in the presence of basic-state wind

    Science.gov (United States)

    Seo, Jaemyeong Mango; Ganbat, Gantuya; Han, Ji-Young; Baik, Jong-Jin

    2017-02-01

    Many big cities around the world are located near mountains. In city-mountain regions, thermally and topographically forced local winds are produced and they affect the transport of pollutants emitted into the urban atmosphere. A better understanding of the dynamics of thermally and topographically forced local winds is necessary to improve the prediction of local winds and to cope with environmental problems. In this study, we theoretically examine the interactions of urban breezes with mountain slope winds in the presence of basic-state wind within the context of the response of a stably stratified atmosphere to prescribed thermal and mechanical forcing. The interactions between urban breezes and mountain slope winds are viewed through the linear superposition of individual analytical solutions for urban thermal forcing, mountain thermal forcing, and mountain mechanical forcing. A setting is considered in which a city is located downwind of a mountain. In the nighttime, in the mountain-side urban area, surface/near-surface horizontal flows induced by mountain cooling and mountain mechanical forcing cooperatively interact with urban breezes, resulting in strengthened winds. In the daytime, in the urban area, surface/near-surface horizontal flows induced by mountain heating are opposed to urban breezes, giving rise to weakened winds. It is shown that the degree of interactions between urban breezes and mountain slope winds is sensitive to mountain height and basic-state wind speed. Particularly, a change in basic-state wind speed affects not only the strength of thermally and mechanically induced flows (internal gravity waves) but also their vertical wavelength and decaying rate. The examination of a case in a setting in which a city is located upwind of a mountain reveals that basic-state wind direction is an important factor that significantly affects the interactions of urban breezes with mountain slope winds.

  15. Effects of Flipped Learning Using Online Materials in a Surgical Nursing Practicum: A Pilot Stratified Group-Randomized Trial.

    Science.gov (United States)

    Lee, Myung Kyung; Park, Bu Kyung

    2018-01-01

    This study examined the effect of flipped learning in comparison to traditional learning in a surgical nursing practicum. The subjects of this study were 102 nursing students in their third year of university who were scheduled to complete a clinical nursing practicum in an operating room or surgical unit. Participants were randomly assigned to either a flipped learning group (n = 51) or a traditional learning group (n = 51) for the 1-week, 45-hour clinical nursing practicum. The flipped-learning group completed independent e-learning lessons on surgical nursing and received a brief orientation prior to the commencement of the practicum, while the traditional-learning group received a face-to-face orientation and on-site instruction. After the completion of the practicum, both groups completed a case study and a conference. The student's self-efficacy, self-leadership, and problem-solving skills in clinical practice were measured both before and after the one-week surgical nursing practicum. Participants' independent goal setting and evaluation of beliefs and assumptions for the subscales of self-leadership and problem-solving skills were compared for the flipped learning group and the traditional learning group. The results showed greater improvement on these indicators for the flipped learning group in comparison to the traditional learning group. The flipped learning method might offer more effective e-learning opportunities in terms of self-leadership and problem-solving than the traditional learning method in surgical nursing practicums.

  16. Effects of Flipped Learning Using Online Materials in a Surgical Nursing Practicum: A Pilot Stratified Group-Randomized Trial

    Science.gov (United States)

    Lee, Myung Kyung

    2018-01-01

    Objectives This study examined the effect of flipped learning in comparison to traditional learning in a surgical nursing practicum. Methods The subjects of this study were 102 nursing students in their third year of university who were scheduled to complete a clinical nursing practicum in an operating room or surgical unit. Participants were randomly assigned to either a flipped learning group (n = 51) or a traditional learning group (n = 51) for the 1-week, 45-hour clinical nursing practicum. The flipped-learning group completed independent e-learning lessons on surgical nursing and received a brief orientation prior to the commencement of the practicum, while the traditional-learning group received a face-to-face orientation and on-site instruction. After the completion of the practicum, both groups completed a case study and a conference. The student's self-efficacy, self-leadership, and problem-solving skills in clinical practice were measured both before and after the one-week surgical nursing practicum. Results Participants' independent goal setting and evaluation of beliefs and assumptions for the subscales of self-leadership and problem-solving skills were compared for the flipped learning group and the traditional learning group. The results showed greater improvement on these indicators for the flipped learning group in comparison to the traditional learning group. Conclusions The flipped learning method might offer more effective e-learning opportunities in terms of self-leadership and problem-solving than the traditional learning method in surgical nursing practicums. PMID:29503755

  17. Reducibility study of Rossetta ilmenite ore briquettes and powder with coke breeze at 800-1100°C

    Directory of Open Access Journals (Sweden)

    Abd el Gawad Hala H.

    2013-01-01

    Full Text Available Ilmenite ore fine and coke breeze as reduced material were briquetted with different amounts of organic materials such as molasses or pitch were studied in this investigation. The produced briquettes at reasonable condition were reduced in nitrogen atmosphere at temperature range 800 - 1100oC to determine the factors controlling the reduction and to determine the controlling mechanism. Also ilmenite ore fine with coke breeze were reduced at the same temperature range in nitrogen atmosphere without briquetting process, for the sake of comparison.

  18. Chemoprevention of Melanoma

    Science.gov (United States)

    Madhunapantula, SubbaRao V.; Robertson, Gavin P.

    2013-01-01

    Despite advances in drug discovery programs and molecular approaches for identifying the drug targets, incidence and mortality rates due to melanoma continues to rise at an alarming rate. Existing preventive strategies generally involve mole screening followed by surgical removal of the benign nevi and abnormal moles. However, due to lack of effective programs for screening and disease recurrence after surgical resection there is a need for better chemopreventive agents. Although sunscreens have been used extensively for protecting from UV-induced skin cancer, results of correlative population based studies are controversial, requiring further authentication to conclusively confirm the chemoprotective efficacy of sunscreens. Certain studies suggest increased skin-cancer rates in sunscreen users. Therefore, effective chemopreventive agents for preventing melanoma are urgently required. This book-chapter, reviews the current understanding regarding melanoma chemoprevention and the various strategies used to accomplish this objective. PMID:22959032

  19. The Immunology of Melanoma.

    Science.gov (United States)

    Ko, Jennifer S

    2017-09-01

    The relatively high DNA mutational burden in melanoma allows for the creation of potentially "foreign," immune-stimulating neoantigens, and leads to its exceptional immunogenicity. Brisk tumor-infiltrating lymphocytes, a marker of immune editing, confer improved overall survival in melanoma, possibly due to reduced sentinel lymph node spread. Meanwhile, T-cell-stimulating drugs, so-called T-cell checkpoint inhibitors, which reverse peripheral tolerance-dependent tumor escape, have demonstrated unparalleled clinical success in metastatic melanoma. Markers to predict response to immunotherapy are currently imperfect, and the subject of intense research, which will guide the future of ancillary pathologic testing in this setting. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Numerical simulation of sea breezes over the Auckland region, New Zealand — Air quality implications

    Science.gov (United States)

    McKendry, Ian G.

    1989-10-01

    The air pollution meteorology of a typical sea breeze day is investigated using the Colorado State University Mcsoscale Model. Results are qualitatively compared with observations and reveal a complex wind field characterised by migratory sea breeze convergence zones. Associated with these features, the model predicts enhanced upward vertical velocities and ‘doming’ of the planetary boundary layer (PBL). The diurnal variation in PBL depth is shown to vary markedly at different locations and is dependent on position in relation to the migratory convergence zones. These complex spatial and temporal variations in the wind and PBL depth have important implications for air quality in Auckland and confirm that simple Gaussian or box trajectory approaches are inappropriate for air quality assessment in such environments. The inclusion in the model of variable surface properties, a dynamic synoptic state and improved PBL parameterisations, as well as coupling with a Lagrangian particle model, are recommended if the model is to be used as a tool for further air quality studies in the Auckland area.

  1. Scrutinizing Practicum for a More Powerful Teacher Education: A Longitudinal Study with Pre-Service Teachers

    Science.gov (United States)

    Serdar Tülüce, Hande; Çeçen, Sevdeger

    2016-01-01

    This study aims to explore the role of school-based practicum in promoting pre-service English language teachers' professional development through the use of a longitudinal design in combination with qualitative methods. To achieve this aim, pre-service teachers were asked to successively reflect on video-recordings of their micro-lessons in their…

  2. Maximizing Target Language Use in a Pre-­Service Practicum: Tensions, Power, and Identity Formation

    Science.gov (United States)

    Parks, Susan

    2015-01-01

    This study draws from a cultural-historical perspective to explore the experiences of two pre-­service ESL teachers in terms of their efforts to maximize the use of the target language during a school practicum. Both student teachers were fluent in English, had received training in maximizing target language use during their university studies,…

  3. Online Learning Management Systems (LMS) and Sense of Community: A Pre-Service Practicum Perspective

    Science.gov (United States)

    Rideout, Glenn; Bruinsma, Robert; Hull, John; Modayil, Jacob

    2007-01-01

    This paper examines the impact of the implementation of an online learning management system (LMS) on pre­-service teachers during their major pre-­service practicum. The LMS enabled students to remain connected to peers, professors, and supervisors while new relationships were formed with in­school personnel such as mentor teachers, principals,…

  4. Practicum Learnings for Counseling and Art Therapy Students: The Shared and the Particular

    Science.gov (United States)

    Van Lith, Theresa; Voronin, Lorelei

    2016-01-01

    Practicum experience in counseling and therapy training can be an anxiety-inducing time as students begin to apply their acquired theoretical knowledge. On-site supervisors closely monitor students' development by making use of example-based involvements to provide valuable insights and learning opportunities. This paper examines the findings from…

  5. Bridging Community Generational Gaps through Experiential Learning: A College Nursing Student Practicum for Elderly Patients

    Science.gov (United States)

    Pate, Jane D.

    2013-01-01

    At the study site, an elder care practicum was adopted after nursing students demonstrated a lack of interest in the well-being of elderly patients. The purpose of the study was to determine if there was a change in college nursing students' attitudes toward nursing home residents as a result of increased intergenerational exposure following an…

  6. Opportunities and Barriers of Practicum from the Perspectives of English Language Student Teachers

    Science.gov (United States)

    Masadeh, Thouqan Saleem Yakoub

    2017-01-01

    The study investigated the perspectives of student teachers regarding the opportunities provided by Practicum course, in addition to the barriers that potentially inhibited their performance as teachers. The descriptive approach was used to identify these opportunities and barriers. Participants were (27) females and (31) males. They were all…

  7. A Phenomenological Study: The Experience of Live Supervision during a Pre-Practicum Counseling Techniques Course

    Science.gov (United States)

    Koltz, Rebecca L.; Feit, Stephen S.

    2012-01-01

    The experiences of live supervision for three, master's level, pre-practicum counseling students were explored using a phenomenological methodology. Using semi-structured interviews, this study resulted in a thick description of the experience of live supervision capturing participants' thoughts, emotions, and behaviors. Data revealed that live…

  8. Experiences of Student Speech-Language Pathology Clinicians in the Initial Clinical Practicum: A Phenomenological Study

    Science.gov (United States)

    Nelson, Lori A.

    2011-01-01

    Speech-language pathology literature is limited in describing the clinical practicum process from the student perspective. Much of the supervision literature in this field focuses on quantitative research and/or the point of view of the supervisor. Understanding the student experience serves to enhance the quality of clinical supervision. Of…

  9. The Seminar Practicum: A Community Based Instructional System for Paraprofessional Education.

    Science.gov (United States)

    Powers, Thomas F.; And Others

    The instructional system which emerged from the Pennsylvania State University three-year project was a seminar practicum for Hotel and Food Service paraprofessional workers which provides work experience, a set of self-instructional modules, subject matter, a weekly seminar discussion, and encourages minority/lower income students. A summary of…

  10. Learning in the Practicum: Engaging Pre-Service Teachers in Reflective Practice in the Online Space

    Science.gov (United States)

    Jones, Mellita; Ryan, Josephine

    2014-01-01

    It is argued that online discussion is a useful tool for creating opportunities for learning in teacher education. In a project designed to improve the practicum in rural areas, researchers placed pre-service teachers (PSTs) in two different moderated online discussion forums: an unstructured personal blog space and a structured threaded…

  11. Cultivating Pre-Service Teachers' Classroom Management Skills through Teaching Practicum: A Reflective Practice

    Science.gov (United States)

    Ragawanti, Debora Tri

    2015-01-01

    Classroom management is commonly believed to be the key to the success of an instruction. Many student teachers, however, might find it very challenging to handle their classrooms. It is, therefore, necessary to advance their professional practice in the context of a real classroom such as through teaching practicum and reflective practice. This…

  12. Piloting a Web-Based Practicum Support Tool: Associate Teachers' Perceived Benefits and Drawbacks

    Science.gov (United States)

    Petrarca, Diana

    2014-01-01

    This pilot study explored how a small group of associate teachers responded to a web-based learning tool created specifically to support them in mentoring teacher candidates during the practicum component of an initial teacher education program in Southern Ontario, Canada. The learning tool's content drew from the teacher education literature, and…

  13. Mental Health Nursing Practicum: Student and Mentor Perspectives on Stress and Satisfaction

    Science.gov (United States)

    Gelabert-Vilella, Sandra; Bonmati-Tomàs, Anna; Bosch-Farré, Cristina; Malagón-Aguilera, M. Carmen; Fuentes-Pumarola, Concepció; Ballester-Ferrando, David

    2014-01-01

    Nursing students begin to complete practicum experiences during their first year, increasing the number of applied credits as they progress toward degree completion. This contributes to integrating knowledge and skills from all of their courses and to obtaining the basic competencies of the nursing profession. It is also essential to identify the…

  14. Social Work Students' Experiences with Group Work in the Field Practicum

    Science.gov (United States)

    Knight, Carolyn

    2017-01-01

    The study reported on in this article assessed MSW and BSW students' opportunities to practice group work in their field practicum. More than one third of participants had no such opportunity during their yearlong internship, despite their program's requirement that group work opportunities be available. Among the students who did have experience…

  15. A Social Media Practicum: An Action-Learning Approach to Social Media Marketing and Analytics

    Science.gov (United States)

    Atwong, Catherine T.

    2015-01-01

    To prepare students for the rapidly evolving field of digital marketing, which requires more and more technical skills every year, a social media practicum creates a learning environment in which students can apply marketing principles and become ready for collaborative work in social media marketing and analytics. Using student newspapers as…

  16. Pre-Service Primary Teachers Negotiating Physical Education Identities during the Practicum

    Science.gov (United States)

    Fletcher, Tim; Kosnik, Clare

    2016-01-01

    This research examined the ways in which pre-service primary teachers' experiences of physical education during the practicum influenced the development of their identities as teachers of physical education. Guided by a social constructivist view of identity, semi-structured interviews were conducted with 10 pre-service teachers over one academic…

  17. Practicum Experience: Pre-Service Teachers' Self-Perception of Their Professional Growth

    Science.gov (United States)

    Choy, Doris; Wong, Angela F. L.; Goh, Kim Chuan; Low, Ee Ling

    2014-01-01

    This paper examined undergraduate pre-service teachers' perceptions of their expectations, fulfilment of these expectations and the relevance of their coursework for classroom practices during three different practicum attachments. These aspects were assessed using questionnaires implemented at the end of each attachment. One-way ANOVA with…

  18. Understanding Student-Teachers' Performances within an Inquiry-Based Practicum

    Science.gov (United States)

    Méndez Rivera, Pilar; Pérez Gómez, Francisco

    2017-01-01

    The role of an inquiry-based practicum in the education of future teachers has been identified as a key component to foster student-teachers' abilities to face problems, try to solve them, work on doubts and produce situated and valuable learning from their own practices (Cochran-Smith & Little, 2001; Beck, 2001). The interaction between…

  19. Pre-Service English Teachers' Voices about the Teaching Practicum

    Science.gov (United States)

    Castañeda-Trujillo, Jairo Enrique; Aguirre-Hernández, Ana Jackelin

    2018-01-01

    This paper shows the results of a pedagogical experience with a group of pre-service English teachers during their first semester of teaching practicum. The data were collected by means of reflection papers written by them, and then the resulting papers were analyzed under the principles of codification of grounded theory. The results show that…

  20. The Practicum Course Model: Embracing the Museum-University Culture Clash

    Science.gov (United States)

    Kingsley, Jennifer P.

    2016-01-01

    Museums and universities have natural connections. Yet with few exceptions, collaborations between them segregate each partner to its traditional sphere of activity. This article presents a practicum course model that blurs and overlaps the distinctive roles of the museum and university in productive and mutually beneficial ways. In particular,…

  1. The Usage of Recycle Materials for Science Practicum: Is There Any Effect on Science Process Skills?

    Science.gov (United States)

    Prajoko, Setiyo; Amin, Mohamad; Rohman, Fatchur; Gipayana, Muhana

    2017-01-01

    This study aimed at determining the effect of recycle materials usage for science practicum on students' basic science process skills of the Open University, Surakarta. Recycle materials are the term used for the obtained materials and equipment from the students' environment by taking back the garbage or secondhand objects into goods or new…

  2. FEHR-PRACTICUM: Information Bank for Project Head Start. Problems 4-8.

    Science.gov (United States)

    Collet, LaVerne S.

    The Formative Evaluation and Heuristic Research (FEHR) PRACTICUM, a computerized game, gives practical experience in such program evaluation tasks as problem definition, operationalizing objectives, field study, budgeting, proposal writing, data analysis, and interpretation--without the expense and time commitments required by most research. The…

  3. FEHR-PRACTICUM: Requests for Proposals for Perceptual Handicaps. Problems 1-8.

    Science.gov (United States)

    Collet, LeVerne S.

    The Formative Evaluation and Heuristic Research (FEHR) PRACTICUM, a computerized game, gives practical experience in such program evaluation tasks as problem definition, operationalizing objectives, field study, budgeting, proposal writing, data analysis, and interpretation--without the expense and time commitments required by most research. The…

  4. FEHR-PRACTICUM: Information Bank for Perceptual Handicaps. Problems 1-3.

    Science.gov (United States)

    Collet, LeVerne S.

    The Formative Evaluation and Heuristic Research (FEHR) PRACTICUM, a computerized game, gives practical experience in such program evaluation tasks as problem definition, operationalizing objectives, field study, budgeting, proposal writing, data analysis, and interpretation--without the expense and time commitments required by most research. The…

  5. On-the-Job Training for Novice ESL Writing Tutors: A Practicum Model.

    Science.gov (United States)

    Beebout, Linda

    2003-01-01

    Highlights a practicum course designed to train upper-level undergraduates as English-as-a-Second-Language (ESL) writing tutors for their peers. The course offers tutors intensive, basic training in tutoring, TESL, and pedagogical grammar for 2 weeks before they begin tutoring. (Author/VWL)

  6. "L'arte D'arrangiarsi": Evaluation of an Innovative Practice in a Preservice Practicum

    Science.gov (United States)

    Macy, Marisa; Squires, Jane

    2009-01-01

    Building on Opportunities for Student Teaching and Learning (BOOST) is a community-based summer preschool program developed, implemented, and coordinated by student teachers, university supervisors, and faculty. Ten preservice graduate students participated in BOOST practicum activities during the spring and summer terms of their 1-year Early…

  7. A Reflection on Bakhtin's "Epic and Novel" in the Context of Early Childhood Student Teachers' Practicum

    Science.gov (United States)

    Naughton, Christopher

    2016-01-01

    It is common in early childhood education (ECE), for student teachers to be asked to reflect on incidents or scenarios that occur while on practicum and relate their reflections to "theory." This process of identification and corroboration, demonstrates the student's familiarity with the dominant developmental narratives within which ECE…

  8. Facebook and the Final Practicum: The Impact of Online Peer Support in the Assistant Teacher Program

    Science.gov (United States)

    Paris, Lisa F.; Boston, Julie; Morris, Julia

    2015-01-01

    Australian pre-service teachers (PST) frequently report feeling isolated and vulnerable during the high stakes Assistant Teacher Program (ATP) final practicum. Mentoring and online learning communities have been shown to offer effective support during periods in which pre-service and beginning teachers feel challenged. As social media…

  9. Angiogenesis and Melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Ribatti, Domenico, E-mail: ribatti@anatomia.uniba.it; Annese, Tiziana; Longo, Vito [Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G. Cesare, 11, Policlinico 70124, Bari (Italy)

    2010-02-25

    Angiogenesis occurs in pathological conditions, such as tumors, where a specific critical point in tumor progression is the transition from the avascular to the vascular phase. Tumor angiogenesis depends mainly on the release by neoplastic cells of growth factors specific for endothelial cells, which are able to stimulate the growth of the host’s blood vessels. This article summarizes the literature concerning the relationship between angiogenesis and human melanoma progression. The recent applications of antiangiogenic agents which interfere with melanoma progression are also described.

  10. Evaluation of the Practicum for Teaching Degrees from the Students’ Perspective

    Directory of Open Access Journals (Sweden)

    Michelle Mendoza-Lira

    2014-09-01

    Full Text Available The Practicum –understood not only as external practices developed by future teachers in schools, but also as the tutorials, seminars and projects done at the University–, is an essential component of initial teacher training. Given the importance of this topic, this paper includes the results obtained in a trans-sectional quantitative descriptive study focused on learning how sampled students from the Primary Teaching and Preschool Teaching Degree Programs from a public university in Madrid evaluate the organization of Practicums I and II, and the support they received from related personnel from the University and the education institution where the practicums took place. A questionnaire was designed to obtain this information from students from these programs and was answered by 426 students. To validate the questionnaire, the Lawshe’s formula was used, which establishes a Content Validity Index (CVI of 0.62, with ten expert judges for agreement not to be reached by chance. In addition, the information provided by the sample was coded in a database for further processing with SPSS 15.0. Using this software, descriptive analyzes were performed to determine the distribution of the sample in each of the variables defined in this study. Finally, results showed a clear tendency to perceive the training institution (the University and its most representative agent (tutor as insufficient to meet the demands for emotional, professional and pedagogical support. On the contrary, centers where practicum is conducted and collaborating teachers are seen not only as the main sources of orientation and guidance during the Practicum, but also as references in the acquisition and development of professional competences.

  11. DESARROLLO DE COMPETENCIAS EN EL PRACTICUM DE MAESTROS: ABPY COACHING MULTIDIMENSIONAL

    Directory of Open Access Journals (Sweden)

    Antonio J. Rodríguez-Hidalgo

    2015-01-01

    Full Text Available Esta investigación pretende contribuir al conocimiento de la influencia del Practicumen el desarrollo de competencias por parte de los maestros y maestras en su formación inicial. Se expone una revisión de estudios en esta materia y la evolución de la metodología docente empleada en Practicum en la Facultad de Ciencias de la Educación de la Universidad de Córdoba. Se presentan las bases del modelo actual de Practicum, focalizado en el Aprendizaje Basado en Problemas mediante Coaching Multidimensional (modelo ABP-CM especialmente diseñado para potenciar el desarrollo de competencias. Se realizó un estudio pretest/postest con la finalidad de estudiar el impacto del Practicum bajo el modelo ABP-CM sobre la propia percepción del alumnado del desarrollo de sus competencias. Entre pretest y postest solo medió la experiencia formativa de Prácticum I del grado de Educación Primaria. En el pretest participaron 145 estudiantes y en el postest 196. Los datos se recogieron mediante un cuestionario auto-informe compuesto por ítems sobre el grado auto-percibido de desarrollo de competencias transversales, específicas y prácticas. Los resultados muestran un avance significativo en el desarrollo auto-percibido de la mitad de las competencias. Se vieron mejoradas: un tercio de las competencias transversales (especialmente las personales y sistémicas; más dela mitad de las competencias específicas; y tres cuartas partes de las competencias concretas de Practicum. La naturaleza de muchas de las competencias más beneficiadas es concordante con la naturaleza de las estrategias docentes empleadas, lo que nos lleva a inferir que el modelo ABP-CM desarrollado en Practicum es un buen catalizador para el desarrollo y cristalización de competencias.

  12. Melanoma Risk Prediction Models

    Science.gov (United States)

    Developing statistical models that estimate the probability of developing melanoma cancer over a defined period of time will help clinicians identify individuals at higher risk of specific cancers, allowing for earlier or more frequent screening and counseling of behavioral changes to decrease risk.

  13. Congenital uveal melanoma?

    Science.gov (United States)

    Singh, Arun D; Schoenfield, Lynn A; Bastian, Boris C; Aziz, Hassan A; Marino, Meghan J; Biscotti, Charles V

    2016-01-01

    A 3-month-old infant with a white mother and Asian father presented with discoloration and prominence of the left eye since birth. Examination revealed a normal right eye. The left eye had hyperchromic heterochromia and an enlarged cornea (diameter, 13.0 mm) with intraocular pressure of 26 mm Hg. There were multiple areas of subconjunctival nodular pigmentation that extended posteriorly into the superior fornix. Fundus examination showed a large ciliochoroidal pigmented mass extending from 10:30 to 3:00 o'clock position involving the superior half of the choroid and adjacent ciliary body. The eye was enucleated, confirming the diagnosis of diffuse uveal melanoma with extraocular extension. Systemic surveillance (hepatic panel and ultrasonography of the liver) performed every 6 months for 5 years was has been negative for metastases. The tumor was investigated intensively for the panel of genes (BAP1, BRAF, NRAS12, NRAS61, GNAQ, Kit 9,11,13,17,18) implicated in pathogenesis of blue nevus, cutaneous melanoma, and mucosal melanomas with negative results. Moreover, germline BAP1 mutation could not be identified. This case possibly represents as yet unidentified uveal melanocytic proliferation rather than a true variant of uveal melanoma. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Interleukin-6 and melanoma

    DEFF Research Database (Denmark)

    Hoejberg, Lise; Bastholt, Lars; Schmidt, Henrik

    2012-01-01

    Interleukin-6 (IL-6) is a pleiotropic immunomodulatory cytokine produced by various types of cells, including melanoma cells. IL-6 plays a major role in the pathogenesis and development of malignancies. It promotes tumour growth by inhibition of apoptosis and induces tumour angiogenesis. IL-6...

  15. Melanoma risk prediction models

    Directory of Open Access Journals (Sweden)

    Nikolić Jelena

    2014-01-01

    Full Text Available Background/Aim. The lack of effective therapy for advanced stages of melanoma emphasizes the importance of preventive measures and screenings of population at risk. Identifying individuals at high risk should allow targeted screenings and follow-up involving those who would benefit most. The aim of this study was to identify most significant factors for melanoma prediction in our population and to create prognostic models for identification and differentiation of individuals at risk. Methods. This case-control study included 697 participants (341 patients and 356 controls that underwent extensive interview and skin examination in order to check risk factors for melanoma. Pairwise univariate statistical comparison was used for the coarse selection of the most significant risk factors. These factors were fed into logistic regression (LR and alternating decision trees (ADT prognostic models that were assessed for their usefulness in identification of patients at risk to develop melanoma. Validation of the LR model was done by Hosmer and Lemeshow test, whereas the ADT was validated by 10-fold cross-validation. The achieved sensitivity, specificity, accuracy and AUC for both models were calculated. The melanoma risk score (MRS based on the outcome of the LR model was presented. Results. The LR model showed that the following risk factors were associated with melanoma: sunbeds (OR = 4.018; 95% CI 1.724- 9.366 for those that sometimes used sunbeds, solar damage of the skin (OR = 8.274; 95% CI 2.661-25.730 for those with severe solar damage, hair color (OR = 3.222; 95% CI 1.984-5.231 for light brown/blond hair, the number of common naevi (over 100 naevi had OR = 3.57; 95% CI 1.427-8.931, the number of dysplastic naevi (from 1 to 10 dysplastic naevi OR was 2.672; 95% CI 1.572-4.540; for more than 10 naevi OR was 6.487; 95%; CI 1.993-21.119, Fitzpatricks phototype and the presence of congenital naevi. Red hair, phototype I and large congenital naevi were

  16. Identification of the Sea-Land Breeze Event and Influence to the Convective Activities on the Coast of Deli Serdang

    Science.gov (United States)

    Saragih, I. J. A.; Putra, A. W.; Nugraheni, I. R.; Rinaldy, N.; Yonas, B. W.

    2017-12-01

    Located close to the sea indicates that there are influences of the sea-land breeze circulation on the weather condition in Deli Serdang. The purpose of this study is to simulate sea-land breeze occurrence and its influence on the convective activities in Deli Serdang. The research area covers the area of Deli Serdang Regency and the surrounding ocean region in the coordinates 02°57‧-03°16‧N & 98°33‧-99°27‧E where Kualanamu Meteorological Station is the centre of the research area at coordinate 03°34‧N & 98°44‧E and the elevation about 27MAMSL. The research time is a day with the highest rainfall in the highest peak rainy month. The raw data consist of the Himawari-8 satellite image from BMKG, FNL (Final Analysis) data from http://rda.ucar.edu, and meteorological observation data from Kualanamu Meteorology Station. This study indicates that WRF-ARW can simulate the sea-land breeze occurrence on the coast of Deli Serdang well. The existence of the convective index cover in the convergence area proves the sea-land breeze occurred in the coast of Deli Serdang can form the convergence area as the interacted result with the wind from other directions that support convective activities.

  17. RARE METASTASES OF MALIGNANT MELANOMA

    Directory of Open Access Journals (Sweden)

    Marija Trenkić-Božinović

    2014-09-01

    Full Text Available Melanomas are malignant neoplasms that originate from melanocytes. The most common are on the skin and mucous membranes. Choroidal melanomas are quite different from cutaneous melanomas with regard to presentation, metastases, and treatment. We report two cases of metastatic gastric malignant melanoma of the eye and skin, with reference to the literature. The first patient was a woman aged 23 years, who underwent gastrectomy 22 months after enucleation of the eye due to malignant choroid melanoma. The second patient was a man, 72 years old, who underwent surgery 28 months before because of malignant melanoma of the skin of the forehead. Paraffin sections, 4 μm thick were stained using a classic method, as well as immunohistochemical DAKO APAAP method, using a specific S - 100 antibody and Melan A antibodies. The stomach is considered a rare place for the development of metastases. Metastases in the stomach are often limited to the submucosal as well as the serousmuscular layer, as noted in one of our patients. Metastatic melanoma of the gastrointestinal tract should be suspected in any patient with a history of malignant melanoma and new gastrointestinal symptoms. Because of the similarity between certain common histopathological types of malignant melanoma, primarily achromatic, and types of primary cancers of the stomach, the following immunohistochemical studies are needed: Melan A and S - 100 protein ( markers of malignant melanoma , as well as mucins: MUC5AC, MUC2 and CDX2 ( markers of different types of primary gastric carcinoma.

  18. Possible impacts of the pre-monsoon dry line and sea breeze front on nocturnal rainfall over northeast Bangladesh

    Science.gov (United States)

    Stiller-Reeve, Mathew; Toniazzo, Thomas; Kolstad, Erik; Spengler, Thomas

    2017-04-01

    The northeast region of Bangladesh receives a large amount of rainfall before the large-scale monsoon circulation begins. For example, in April (a "pre-monsoon" month) 2010, 804 mm of rain fell in the regional capital Sylhet. It was the second wettest month of the entire year. From our conversations with the local people, we know that this pre-monsoon rainfall is extremely important to their livelihoods. We therefore need to understand it's triggering mechanisms. Several theories have been published, all of which are likely to be at play. However, in this work we look more closely at how the sea breeze front and prominent pre-monsoonal dry line in this region may play a role. If these mechanisms play a role in the convection, then it is likely that they trigger convection further afield, and then the resulting systems then propagate towards northeast Bangladesh. We believe this because rainfall associated with dry line/sea-breeze front convection often occurs during the late afternoon, but the rainfall over northeast Bangladesh shows a clear late-night/early-morning maxima. At present, the temporal and spatial resolution of the regional observations is inappropriate for examining these possible mechanisms. We therefore use a numerical model (WRF) to investigate the possible links between the convection and the sea breeze front and dry line. We use April 2010 as a case study since it was such a wet pre-monsoon month. The simulation shows that a sea breeze circulation often develops during the day in the coastal zone of Bangladesh and northeast India. After sunset the sea breeze front propagates inland pushing back the hot, dry air over India. On several days during the simulation, convection is triggered along the sea breeze front, which then propagates towards northeast Bangladesh and intensifies across the topography surrounding the Sylhet region. From our simulations, it appears that nocturnal convection over northeast Bangladesh is triggered by several

  19. Proper Technique for Administration of ATX-101 (Deoxycholic Acid Injection): Insights From an Injection Practicum and Roundtable Discussion.

    Science.gov (United States)

    Jones, Derek H; Kenkel, Jeffrey M; Fagien, Steven; Glaser, Dee Anna; Monheit, Gary D; Stauffer, Karen; Sykes, Jonathan M

    2016-11-01

    ATX-101 (deoxycholic acid injection; Kybella in the United States and Belkyra in Canada; Kythera Biopharmaceuticals, Inc., Westlake Village, CA [an affiliate of Allergan plc, Dublin, Ireland]) is the first aesthetic injectable approved for reduction of submental fat. In February 2014, an injection practicum was conducted in the anatomy laboratory at the University of Texas Southwestern Medical Center to explore the proper injection technique for ATX-101 and the importance of its appropriate, safe anatomical placement within the submental area. Subsequent to the injection practicum, a structured roundtable discussion was conducted in which potential implications of the various injection protocols evaluated during the practicum were reviewed. Furthermore, the faculty had the opportunity to provide additional perspectives based on their clinical experience with facial injectables and ATX-101 specifically. In this article, the findings from the injection practicum and roundtable discussion are reported.

  20. Communication about melanoma and risk reduction after melanoma diagnosis.

    Science.gov (United States)

    Rodríguez, Vivian M; Berwick, Marianne; Hay, Jennifer L

    2017-12-01

    Melanoma patients are advised to perform regular risk-reduction practices, including sun protection as well as skin self-examinations (SSEs) and physician-led examinations. Melanoma-specific communication regarding family risk and screening may promote such behaviors. To this end, associations between patients' melanoma-specific communication and risk reduction were examined. Melanoma patients (N = 169) drawn from a population-based cancer registry reported their current risk-reduction practices, perceived risk of future melanoma, and communication with physicians and relatives about melanoma risk and screening. Patients were, on average, 56 years old and 6.7 years' post diagnosis; 51% were male, 93% reported "fair/very fair" skin color, 75% completed at least some college, and 22% reported a family history of melanoma. Patients reported varying levels of regular (always/nearly always) sun protection: sunscreen use (79%), shade seeking (60%), hat use (54%), and long-sleeve shirt use (30%). Only 28% performed thorough SSE regularly, whereas 92% reported undergoing physician-led skin examinations within the past year. Participants who were female, younger, and had a higher perceived risk of future melanoma were more likely to report past communication. In adjusted analyses, communication remained uniquely associated with increased sunscreen use and SSE. Encouraging melanoma patients to have a more active role in discussions concerning melanoma risk and screening with relatives and physicians alike may be a useful strategy to promote 2 key risk-reduction practices post melanoma diagnosis and treatment. Future research is needed to identify additional strategies to improve comprehensive risk reduction in long-term melanoma patients. Copyright © 2016 John Wiley & Sons, Ltd.

  1. Principal beliefs, experiences, and barriers to involvement with student teachers during the practicum component of initial teacher education programs

    OpenAIRE

    Chute, Carey Douglas

    2017-01-01

    Numerous research studies have investigated the significance of Initial Teacher Education (ITE) programs and their practicum in preparing student teachers. The role played by the traditional triad of faculty associate, school associate and student teacher has been studied extensively. However, the principal’s role in the student teacher’s school-based practicum, is often neglected. This study fills that gap and provides Canadian-based data on principal beliefs, self-reported involvement an...

  2. Nursing student and professor perceptions and assessments of the achievement of practicum competencies: A mixed method approach.

    Science.gov (United States)

    Fuentes-Pumarola, Concepció; Ballester-Ferrando, David; Gelabert-Vilella, Sandra; Bosch-Farré, Cristina; Malagón-Aguilera, M Carme; Rascón-Hernán, Carolina; Bonmatí-Tomàs, Anna; Fernandez-Peña, Rosario

    2016-10-01

    Within the context of the European Higher Education Area's requirement of competency-based assessments, the objective of the present study was to evaluate the Nursing Degree Practicum experience at the University of Girona (Spain) and ascertain student and faculty perceptions of the degree of competency achieved as a result of the practicum. This cross-sectional, descriptive, study combined quantitative analysis of a questionnaire and qualitative analysis of focus group comments. In the quantitative part of the study, 163 fourth-year nursing students completed the questionnaire; the qualitative analysis was derived from a focus group of 5 students and 5 professors. On the questionnaire, overall practicum evaluation was 8.39 on a 10-point Likert scale; scores evaluating the nurse mentor/instructor and nursing professor were 8.43 and 7.98, respectively. The geriatrics practicum experience received the lowest overall score (7.81), while the surgical practicum received the lowest score on the adequacy of knowledge acquired in the classroom in previous courses (5.54). The best scores were earned by the mental health and intensive/emergency care practicum experiences (a mean of 9.05 and 8.70, respectively). Students and professors in the focus group agreed that the practicum met the Nursing degree program's competency goals, highlighting practical activity as the best methodology to evaluate competencies. Participants highlighted the importance of reflective practice and the role of the nurse mentor/instructor in student learning, and indicated that it is essential for the university and the health care centers where students take practicum courses to maintain a strong relationship and good communication. Finally, feedback from the nurse mentor/instructor and Nursing professor was very important to students, both to motivate them and to help them learn. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Melanoma Epidemiology and Public Health

    Science.gov (United States)

    Berwick, Marianne; Erdei, Esther; Hay, Jennifer

    2013-01-01

    Melanoma has presented a conundrum to physicians and prevention researchers. We should be able to reduce incidence and mortality rather easily because evolving melanoma lesions are observable on the surface of the skin. However, melanoma has not proved tractable. The incidence and mortality have risen in all developed countries during the past 50 years. However, mortality appears to be abating among younger cohorts even though the reason for this is not clear. PMID:19254665

  4. Melanoma and immunotherapy bridge 2015

    OpenAIRE

    Nanda, Vashisht G. Y.; Peng, Weiyi; Hwu, Patrick; Davies, Michael A.; Ciliberto, Gennaro; Fattore, Luigi; Malpicci, Debora; Aurisicchio, Luigi; Ascierto, Paolo Antonio; Croce, Carlo M.; Mancini, Rita; Spranger, Stefani; Gajewski, Thomas F.; Wang, Yangyang; Ferrone, Soldano

    2016-01-01

    Table of contents MELANOMA BRIDGE 2015 KEYNOTE SPEAKER PRESENTATIONS Molecular and immuno-advances K1 Immunologic and metabolic consequences of PI3K/AKT/mTOR activation in melanoma Vashisht G. Y. Nanda, Weiyi Peng, Patrick Hwu, Michael A. Davies K2 Non-mutational adaptive changes in melanoma cells exposed to BRAF and MEK inhibitors help the establishment of drug resistance Gennaro Ciliberto, Luigi Fattore, Debora Malpicci, Luigi Aurisicchio, Paolo Antonio Ascierto, Carlo M. Croce, Rita Mancin...

  5. Nodular amelanotic melanoma

    Directory of Open Access Journals (Sweden)

    Nalamwar Rashmi

    2010-01-01

    Full Text Available We report a case of 65-year-old male patient who presented with multiple erythematous papules coalescing to form a nodular mass over posterior aspect of right thigh of six months duration. His general and systemic examinations were within normal range except for right inguinal lymphadenopathy. Biopsy from the lesion was done, which showed diffuse infiltrate of nests of atypical melanocytes extending upto reticular dermis. Malignant cells were positive for S100 and human melanin black 45(HMB 45. Hence, a diagnosis of amelanotic melanoma (AM - Clarke level IV and TNM stage III was reached. MRI of involved leg showed fungating soft tissue mass in the posterolateral aspect of right thigh and metastatic right inguinal adenopathy. Fine needle aspiration cytology (FNAC from the right inguinal nodes confirmed metastasis of melanoma. The patient was referred to oncosurgery department for further management.

  6. Dermoscopy of difficult-to-diagnose Melanomas

    Directory of Open Access Journals (Sweden)

    Papageorgiou Chrysoula

    2016-09-01

    Full Text Available Dermoscopy is a non-invasive procedure that allows the evaluation of cutaneous lesions, and is considered to be a useful tool that improves the diagnostic accuracy of melanoma. Many dermoscopic criteria of melanoma have been established and several algorithms have been created for melanoma detection. However, the recognition of some melanomas remains challenging. Melanomas on specific body sites, melanomas in patients with multiple atypical moles, and nodular melanomas represent the most difficult-to-recognize melanoma subtypes, since they typically lack the “classic” melanoma-specific criteria. This paper provides an update on dermoscopy of difficult-to-diagnose melanomas by summarizing the newest data. Lastly, we highlight the importance of digital dermoscopy in the follow-up of melanocytic lesions for the detection of incipient melanomas while maintaining a low excision rate.

  7. Circulating melanoma cells and survival in metastatic melanoma

    NARCIS (Netherlands)

    Rao, C.; Bui, T.; Connelly, M.; Doyle, G.; Karydis, I.; Middleton, M. R.; Clack, G.; Malone, M.; Coumans, F. A. W.; Terstappen, L. W. M. M.

    2011-01-01

    A validated assay for the enumeration of circulating melanoma cells (CMCs) may facilitate the development of more effective therapies for metastatic melanoma patients. In this study CD146(+) cells were immunomagnetically enriched from 7.5 ml of blood. Isolated cells were fluorescently stained with

  8. Online learning management systems (LMS) and sense of community: A pre-service practicum perspective

    OpenAIRE

    Glenn Rideout; Robert Bruinsma; John Hull; Jacob Modayil

    2008-01-01

    This paper examines the impact of the implementation of an online learning management system (LMS) on pre-service teachers during their major pre-service practicum. The LMS enabled students to remain connected to peers, professors, and supervisors while new relationships were formed with in-school personnel such as mentor teachers, principals, and students. The quantitative data analysis revealed that pre-service teachers perceived a higher sense of community when it included pre-service teac...

  9. Constructing professional identity through teaching practicum: an Indonesian case study of pre-service English teachers

    OpenAIRE

    Afrianto, Afrianto

    2017-01-01

    This study investigates the complexities of a group of pre-service teachers’ (PSTs) journey to becoming novice teachers during the teaching practicum in the context of the Indonesian government’s agenda to reform national education, including reforms in the teaching profession. These reforms were a response to current concerns regarding quality education, including the perceived low standards in English Language Teaching (ELT) in Indonesia. The research project, situated in Riau Universi...

  10. Exploring reflective teaching through informed journal keeping and blog group discussion in the teaching practicum

    OpenAIRE

    Insuasty, Edgar Alirio; Zambrano Castillo, Liliana Cecilia

    2010-01-01

    This article reports the findings of a study which examined how student teachers could be empowered as more reflective practitioners through journal keeping and blog group discussions. It was carried out with six student teachers who developed their practicum over six months. Data were collected through journals, blogs, metaphors, conferences and a questionnaire. The results demonstrated that student teachers enriched their perceptions about what reflective teaching implied. Furthermore, jour...

  11. Student Triads: A Collaborative Approach to Practicum Experiences for Master's Nursing Students.

    Science.gov (United States)

    Goodwin, Miki; Jenkins-Weinrub, Edith

    2015-01-01

    This article presents an approach for a collaborative practicum experience for master's degree nursing students. The students were placed into triads and then assigned as a group to work in a large health care organization. A triad consisted of 1 student from each concentration of study: nursing administration, nursing education, or nursing informatics, and the group was immersed in real-time problem-solving and decision-making processes over the course of the year.

  12. Lessons from experience: ESL student teachers' reflection during practicum through reflective journals

    OpenAIRE

    Intan Safinas Mohd Ariff Albakri; Mohd Hassan Abdullah; Ahmad Jazimin Jusoh

    2017-01-01

    Reflection is a prospective alternative in exploring student teachers’ thinking during practicum. The data gained from student teachers’ reflection are significant in informing teacher education programs on how to equip pre-service teachers to become quality teachers. It is also crucial in addressing issues and conflicts highlighted by student teachers when they interact with the real context. This study is conducted with six semester seven student teachers undergoing their Bachelor in Educat...

  13. Nursing Practicum in Gynaecology and Obstetrics - Early Influence Possibilities for a Specialty.

    Science.gov (United States)

    Kasch, R; Baum, P; Dokter, M; Zygmunt, M; Wirkner, J; Lange, A; Fröhlich, S; Merk, H; Kasch, J

    2015-12-01

    Background: The shortage of skilled personnel is ubiquitous, basic and further training is a key aspect in the recruitment of new medical colleagues. The significance of the nursing practicum in its function as gateway to the gynaecology and obstetrics discipline is practically unexplored. Methods: In an online questionnaire, medical students in all German faculties were questioned about the practica in their courses. The questionnaire reached 9079 medical students. 149 participants in nursing practica were selectively asked to answer 140 questions. We analysed those students who could, on the basis of their experiences in nursing practica, imagine undertaking an internship (clinical elective) in gynaecology (internship yes "Iy") separately from those who could not or were still undecided (internship no "In" or, respectively, internship perhaps "Ip"). Results: Altogether 149 medical students who participated in a nursing practicum in the gynaecology discipline were selected, of these 94.9 % were female. 92 (61.7 %) of the students replied that, after their gynaecological nursing practicum, they wanted to undertake an internship in gynaecology (Iy); 39 (26.2 %) answered negatively (In) and 18 (12.1 %) were still undecided (Ip). With regard to the parameters gender, age and duration of study, there were no significant differences among the 3 groups (χ 2  0.83). Besides the didactic and professional quality of the training, Iy also mentioned having had a higher practical orientation. They attained their aims more frequently, were better integrated in the health-care team and acquired more practical competences. Satisfaction with the practicum was evaluated as highest among the Iy. Discussion: Those students who could imagine taking an internship in gynaecology were seen to be more satisfied with their practica than those participants who declined or were undecided. The high proportion of females is an early indicator for a feminisation of the specialty. If

  14. Stratified coastal ocean interactions with hurricanes and the sea breeze in the U.S. Mid-Atlantic

    Science.gov (United States)

    Seroka, Gregory Nicholas

    This dissertation uses the integration of modeling with observations and new analysis techniques to better understand and predict how the stratified coastal ocean interacts with important summer weather processes--tropical cyclones (TCs), which incur large coastal and inland damages, and the sea breeze circulation, which occurs nearly daily in the summer during high electricity demand periods. TC intensity prediction skill lags TC track prediction skill, and the shallow, coastal ocean remains a gap in TC research. The offshore component of the sea breeze is under-observed and poorly understood relative to its onshore component, and has important wind resource implications for the burgeoning U.S. offshore wind energy industry. Using atmospheric modeling and coastal ocean observations with underwater gliders and buoys, it is shown in Hurricane Irene (2011) that stratified coastal ocean cooling--found to occur primarily ahead of the storm's eye center offshore the U.S. Mid-Atlantic--was the key missing contribution in modeling Irene's rapid decay just prior to NJ landfall. Irene's intensity was more sensitive to this cooling than any other model parameter tested, and including this cooling in modeling mitigated the high bias in storm intensity predictions. Using ocean modeling, the spatiotemporal variability in the stratified coastal ocean cooling processes observed in Irene and Tropical Storm Barry (2007) was investigated. It was found that the dominant force balance across the entire Mid-Atlantic shelf ahead of storm eye passage for both storms was onshore wind stress balanced by offshore pressure gradient. This resulted in onshore surface currents opposing offshore bottom currents ahead-of-eye-center and enhancing surface to bottom current shear and surface cooling. Turbulent mixing cooled the surface layer while tides dominated the alternating warming/cooling advection signal. Finally, a new analysis technique, i.e. Lagrangian coherent structures, performed on

  15. ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma

    International Nuclear Information System (INIS)

    Ungerer, Christopher; Doberstein, Kai; Buerger, Claudia; Hardt, Katja; Boehncke, Wolf-Henning; Boehm, Beate; Pfeilschifter, Josef; Dummer, Reinhard; Mihic-Probst, Daniela; Gutwein, Paul

    2010-01-01

    Research highlights: → Strong ADAM15 expression is found in normal melanocytes. → ADAM15 expression is significantly downregulated in patients with melanoma metastasis. → TGF-β can downregulate ADAM15 expression in melanoma cells. → Overexpression of ADAM15 in melanoma cells inhibits migration, proliferation and invasion of melanoma cells. → Conclusion: ADAM15 represents an tumor suppressor protein in melanoma. -- Abstract: In a mouse melanoma metastasis model it has been recently shown that ADAM15 overexpression in melanoma cells significantly reduced the number of metastatic nodules on the lung. Unfortunately, the expression of ADAM15 in human melanoma tissue has not been determined so far. In our study, we characterized the expression of ADAM15 in tissue micro-arrays of patients with primary melanoma with melanoma metastasis. ADAM15 was expressed in melanocytes and endothelial cells of benign nevi and melanoma tissue. Importantly, ADAM15 was significantly downregulated in melanoma metastasis compared to primary melanoma. We further demonstrate that IFN-γ and TGF-β downregulate ADAM15 protein levels in melanoma cells. To investigate the role of ADAM15 in melanoma progression, we overexpressed ADAM15 in melanoma cells. Importantly, overexpression of ADAM15 in melanoma cells reduced the migration, invasion and the anchorage dependent and independent cell growth of melanoma cells. In summary, the downregulation of ADAM15 plays an important role in melanoma progression and ADAM15 act as a tumorsuppressor in melanoma.

  16. ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Ungerer, Christopher; Doberstein, Kai [Pharmazentrum Frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt am Main (Germany); Buerger, Claudia; Hardt, Katja; Boehncke, Wolf-Henning [Department of Dermatology, Clinic of the Goethe-University, Theodor-Stern-Kai, Frankfurt (Germany); Boehm, Beate [Division of Rheumatology, Goethe University, Frankfurt am Main (Germany); Pfeilschifter, Josef [Pharmazentrum Frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt am Main (Germany); Dummer, Reinhard [Department of Pathology, Institute of Surgical Pathology, University Hospital, Zurich (Switzerland); Mihic-Probst, Daniela [Department of Dermatology, University Hospital Zurich (Switzerland); Gutwein, Paul, E-mail: p.gutwein@med.uni-frankfurt.de [Pharmazentrum Frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt am Main (Germany)

    2010-10-22

    Research highlights: {yields} Strong ADAM15 expression is found in normal melanocytes. {yields} ADAM15 expression is significantly downregulated in patients with melanoma metastasis. {yields} TGF-{beta} can downregulate ADAM15 expression in melanoma cells. {yields} Overexpression of ADAM15 in melanoma cells inhibits migration, proliferation and invasion of melanoma cells. {yields} Conclusion: ADAM15 represents an tumor suppressor protein in melanoma. -- Abstract: In a mouse melanoma metastasis model it has been recently shown that ADAM15 overexpression in melanoma cells significantly reduced the number of metastatic nodules on the lung. Unfortunately, the expression of ADAM15 in human melanoma tissue has not been determined so far. In our study, we characterized the expression of ADAM15 in tissue micro-arrays of patients with primary melanoma with melanoma metastasis. ADAM15 was expressed in melanocytes and endothelial cells of benign nevi and melanoma tissue. Importantly, ADAM15 was significantly downregulated in melanoma metastasis compared to primary melanoma. We further demonstrate that IFN-{gamma} and TGF-{beta} downregulate ADAM15 protein levels in melanoma cells. To investigate the role of ADAM15 in melanoma progression, we overexpressed ADAM15 in melanoma cells. Importantly, overexpression of ADAM15 in melanoma cells reduced the migration, invasion and the anchorage dependent and independent cell growth of melanoma cells. In summary, the downregulation of ADAM15 plays an important role in melanoma progression and ADAM15 act as a tumorsuppressor in melanoma.

  17. Lessons from experience: ESL student teachers' reflection during practicum through reflective journals

    Directory of Open Access Journals (Sweden)

    Intan Safinas Mohd Ariff Albakri

    2017-09-01

    Full Text Available Reflection is a prospective alternative in exploring student teachers’ thinking during practicum. The data gained from student teachers’ reflection are significant in informing teacher education programs on how to equip pre-service teachers to become quality teachers. It is also crucial in addressing issues and conflicts highlighted by student teachers when they interact with the real context. This study is conducted with six semester seven student teachers undergoing their Bachelor in Education with honors Teaching English as a Second Language (TESL program. The student teachers were asked to write reflective journal entries throughout the 14 weeks of their teaching practicum experience. The aim of the study is to identify the focus of the student teachers’ reflection and the challenges faced by them during practicum. Data were gathered using the reflective journal entries and semi-structured interviews with all the participants. The data were analyzed according to emerging themes. The findings indicated that the student teachers focus on three main themes in their reflections, which are managing learning, pedagogy and teacher attributes. While the challenges highlighted were difficulty in socializing with members of the institution, lack of professional support and lack of ability to manage a classroom.

  18. Pediatric Melanoma and Drug Development

    Directory of Open Access Journals (Sweden)

    Klaus Rose

    2018-03-01

    Full Text Available Importance—Pediatric melanoma occurs, albeit rarely. Should patients be treated by today’s medical standards, or be subjected to medically unnecessary clinical studies? Observations—We identified international, industry-sponsored pediatric melanoma studies triggered by regulatory demands in www.clinicaltrials.gov and further pediatric melanoma studies demanded by European Union pediatric investigation plans. We retrieved related regulatory documents from the internet. We analyzed these studies for rationale and medical beneficence on the basis of physiology, pediatric clinical pharmacology and rationale. Regulatory authorities define children by chronological age, not physiologically. Newborns’ organs are immature but they develop and mature rapidly. Separate proof of efficacy in underage patients is justified formally/regulatorily but lacks medical sense. Children—especially post-puberty—and adults vis-a-vis medications are physiologically very similar. Two adolescent melanoma studies were terminated in 2016 because of waning recruitment, while five studies in pediatric melanoma and other solid tumors, triggered by European Union pediatric investigation plans, continue recruiting worldwide. Conclusions and Relevance—Regulatory-demanded pediatric melanoma studies are medically superfluous. Melanoma patients of all ages should be treated with effective combination treatment. Babies need special attention. Children need dose-finding and pharmacokinetic studies but adolescents metabolize and respond to drugs similarly to adults. Institutional Review Boards/ethics committees should suspend ongoing questionable pediatric melanoma studies and reject newly submitted questionable studies.

  19. Histopathological findings concerning ocular melanomas.

    Science.gov (United States)

    Costache, Mariana; Pătraşcu, Oana Maria; Dumitru, Adrian; Costache, Diana; Voinea, Liliana Mary; Simionescu, Olga; Sajin, Maria

    2014-01-01

    Ocular melanoma is rare in clinical practice. In this study, we present three cases of ocular melanoma surgically removed in the Department of Ophthalmology of the Emergency University Hospital of Bucharest, Romania, and diagnosed in the Department of Pathology of the same hospital using conventional histopathological techniques and immunohistochemical tests.

  20. Angiogenic profile of uveal melanoma.

    NARCIS (Netherlands)

    Notting, I.C.; Missotten, G.S.; Sijmons, B.; Boonman, Z.F.; Keunen, J.E.E.; Pluijm, G. van der

    2006-01-01

    Uveal melanoma develops in one of the most capillary-rich tissues of the body and is disseminated hematogenously. Knowledge of the nature and the spatiotemporal expression of angiogenic factors in uveal melanoma is essential to the development of new treatment strategies, especially with regard to

  1. Clinical characteristics and management of melanoma families

    NARCIS (Netherlands)

    Rhee, Jasper Immanuel van der

    2013-01-01

    Being a member of a melanoma family is a major risk factor for cutaneous malignant melanoma. In this thesis clinical characteristics and management of melanoma families are discussed. In the first part of the thesis clinical and histological characteristics of melanoma (patients) from families with

  2. Comparative Aspects of Canine Melanoma

    Directory of Open Access Journals (Sweden)

    Adriana Tomoko Nishiya

    2016-02-01

    Full Text Available Melanomas are malignant neoplasms originating from melanocytes. They occur in most animal species, but the dog is considered the best animal model for the disease. Melanomas in dogs are most frequently found in the buccal cavity, but the skin, eyes, and digits are other common locations for these neoplasms. The aim of this review is to report etiological, epidemiological, pathological, and molecular aspects of melanomas in dogs. Furthermore, the particular biological behaviors of these tumors in the different body locations are shown. Insights into the therapeutic approaches are described. Surgery, chemotherapy, radiotherapy, immunotherapy, and the outcomes after these treatments are presented. New therapeutic perspectives are also depicted. All efforts are geared toward better characterization and control of malignant melanomas in dogs, for the benefit of these companion animals, and also in an attempt to benefit the treatment of human melanomas.

  3. A meteorological study of the sea and land breezes in Bangka Indonesia during the total solar eclipse on March 9, 2016

    Science.gov (United States)

    Dwi Ardi, Nanang; Rachmat Tayubi, Yuyu; Gandini, Ryantika; Puji Asmoro, Cahyo; Nurfiani, Dini; Wijaya, Agus Fany Chandra; Ramlan Ramalis, Taufik

    2016-11-01

    Of all mesoscale phenomena, sea and land breezes have been the most studied, both observationally and theoretically. During the total solar eclipse (TSE), some parameters vary anomalously in response to the occurrence of TSE on 9th March 2016 in Bangka, Indonesia. As it occurred during morning hours, it is considered to be much more significant because of its effect in sea and land breezes pattern, especially in term of lag time. We use Portlog Rainwise Automatic Weather Station which is able to measure data in 1 Hz accuracy. Comparison of hourly observations during first contact until final contact result a slow cooling temperature reduction of 0.1°C until totality phase. A significant weakening in wind speed of about 2.5 ms-1 was observed clearly from the instrument. Unfortunately, the reduction is not coincided with the change of wind direction until the third contact. A near constancy in temperature and the wind's behaviour during TSE result delay time in sea and land breezes pattern after the totality. The lag time occurred in three days measurement data, especially sea breeze onset on the next morning day. The lag time in sea breeze was about one hour retardation. The effect of eclipse on the onset timing of sea and land breeze may be attributed to the proportion of heat accumulation due to the obscuration.

  4. Impacts of the land-lake breeze of the Volta reservoir on the diurnal cycle of cloudiness and precipitation

    Science.gov (United States)

    Buchholz, Marcel; Fink, Andreas H.; Knippertz, Peter; Yorke, Charles

    2017-04-01

    Lake Volta in Ghana is the artificial lake on Earth with the largest surface area (8502 km2). It has been constructed in the early 1960s, with the lake being filled around 1966. Land-lake breezes and their effects on the diurnal cycle of local wind systems, cloudiness, and precipitation have been studied for several tropical lakes, among which studies on the effects of Lake Victoria in East Africa are one of the most perceived ones. To date, no studies on the strengths and effects of the land-lake breeze of the Volta reservoir are known to the authors. Using surface station data, a variety of satellite data on clouds and precipitation, and a convection-resolving regional model, the land-lake breeze and its impacts were studied for Lake Volta between 1998 and 2015. The observational data sets confirm a significant land-lake circulation. The only manned weather station operated by the Ghana Meteorological Service that is situated at the lake is Kete Krachi. Hourly observations for 2006 and 2014 show on several days a clearing of skies in the afternoon associated with a shift in the surface winds from southwest to southeast, the latter potentially indicating a lake breeze effect. Cloud occurrence frequency derived from the CLARA-A2, MODIS, and CLAAS2 cloud masks and the cloud physical properties from CLAAS2 clearly show the development of clouds at the lake breeze front in the course of the morning and around mid-day. This effect is most pronounced in March when also the difference between the surface temperatures of the lake and the desiccated land surface is strongest. During the peak of the wet season in July, the lake breeze cloudiness is masked by a high background cloudiness and likely also weaker due to the strong southwesterly monsoon flow that tends to weaken the land-lake circulation. However, the precipitation signal was found to be strongest in July, most probably due to the fact that in boreal fall, winter and spring, the lake breeze cloudiness often

  5. Interactive Tailored Website to Promote Sun Protection and Skin Self-Check Behaviors in Patients With Stage 0-III Melanoma

    Science.gov (United States)

    2017-11-15

    Stage 0 Skin Melanoma; Stage I Skin Melanoma; Stage IA Skin Melanoma; Stage IB Skin Melanoma; Stage II Skin Melanoma; Stage IIA Skin Melanoma; Stage IIB Skin Melanoma; Stage IIC Skin Melanoma; Stage III Skin Melanoma; Stage IIIA Skin Melanoma; Stage IIIB Skin Melanoma; Stage IIIC Skin Melanoma

  6. The influence of the summer sea breeze on thermal comfort in Funchal (Madeira). A contribution to tourism and urban planning.

    Energy Technology Data Exchange (ETDEWEB)

    Lopes, Antonio; Lopes, Sergio; Joao Alcoforado, Maria [Univ. de Lisboa (Portugal). Centro der Estudos Geograficos; Matzarakis, Andreas [Freiburg Univ. (Germany). Meteorological Inst.

    2011-10-15

    Tourism plays a crucial role for the development of coastal areas. Despite the mildness of Madeira's climate, very hot days can occur during summer, a situation to which most tourists from northern Europe (the majority of foreign tourists) are poorly adapted. As sea breezes strongly contribute to moderate heat stress in urban environments, their influence on the thermal comfort on the island has been studied. Sea breezes occurred on 84 % of the days during the period under study (May to October 2006). They usually start around 09:30 h and end after 22:00 h, with an average duration of about 12:50 hours and a mean velocity of 2.9 m/s. Physiologically Equivalent Temperature (PET) was used to evaluate the thermal comfort of a sample of days during the summer of 2006. It was concluded that most of the sites in the city are ''slightly comfortable'' during normal days with sea breeze, but only shore sites and the highest green areas offer some comfort during hot days. Inside the city, the thermal perception is generally ''hot'' and strong heat stress can occur. As sea breezes are important to mitigate heat stress, some basic guidelines were presented: urban planners should take advantage of this wind system avoiding dense construction near the shoreline that would act as a barrier to the renewal of the air inside the city. In terms of tourism, planners and local authorities should provide solutions to mitigate the negative effects during hot periods, creating a system to warn and relocate more vulnerable tourists to places near the shore line, to the mountains, to gardens and air-conditioned buildings. In combination with other components (beauty of the island, gastronomy, cultural values and safety), climate information can be a factor of attractiveness to tourists. (orig.)

  7. Air pollutant transport in a coastal environment. Part 1: Two-dimensional simulations of sea-breeze and mountain effects

    Science.gov (United States)

    Lu, Rong; Turco, Richard P.

    1994-01-01

    Over the southern California coastal region, observations of the vertical distributions of pollutants show that maximum concentrations can occur within temperature inversion layers well above the surface. A mesoscale model is used to study the dynamical phenomena that cause such layers, including sea breezes and mountain flows, and to study the characteristics of air pollutant transport in a coastal environment capped by a temperature inversion. The mathematical and physical structure of the model is described. Two-dimensional simulations corresponding to four configurations of coastal plains and mountains are discussed. The simulations reveal that pollutant transport over a coastal plain is strongly influenced by the topographic configuration, including the height of coastal mountains and their distance from the coastline. Sea breezes induced by land-sea thermal contrasts, as well as upslope winds induced along mountain flanks, both create vertical transport that can lead to the formation of elevated pollution layers. The sea-breeze circulation generates pollution layers by undercutting the mixed layer and lofting pollutants into the stable layer. Heating of mountain slopes acts to vent pollutants above the mountain ridge during the day; during the evening, pollutants can be injected directly into the inversion layer from the decaying upslope flows. In a land-sea configuration with mountains close to the coastline, the sea breeze and heated-mountain flow are strongly coupled. In the afternoon, this interaction can produce upslope flow from which polluted air is detrained into the inversion layer as a return circulation. When the mountains lie farther inland, however, pollutants may be trapped aloft when the mixed layer stabilizes in the late afternoon. As the nocturnal boundary layer forms over the coast in the evening, polluted mixed-layer air is effectively left behind in the inversion layer. In the Los Angeles Basin, the formation mechanism for elevated

  8. Histological Types of Polypoid Cutaneous Melanoma II

    OpenAIRE

    Knežević, Fabijan; Duančić, Vjekoslav; Šitić, Sanda; Horvat-Knežević, Anica; Benković, Vesna; Ramić, Snježana; Kostović, Krešimir; Ramljak, Vesna; Velemir Vrdoljak, Danko; Stanec, Mladen; Božović, Angelina

    2007-01-01

    The aim of this study was to ascertain which histological types of melanoma can clinically and morphologically appear as polypoid melanomas. In 645 cases of primary cutaneous melanoma we have analyzed criteria for diagnosis of polypoid cutaneous melanoma and afterwards we have analyzed growth phase in each polypoid melanoma, histological type of atypical melanocytes, the number of epidermal ridges which are occupied by atypical melanocytes, and distribution according to age, sex a...

  9. Investigating erosion of building materials used in an installation for pneumatic transport of coke breeze and coal

    Energy Technology Data Exchange (ETDEWEB)

    Bandrowski, J.; Kot-Borkowska, Z.; Misztal, M.; Raczek, J.; Kaczmarzyk, G.

    1980-09-01

    This article investigates the influence of the following factors on erosion of building material used in pneumatic transport of coal and coke breeze: intensity of coal or coke breeze flow within the range of 47 to 120 kg/h for coke and 99 to 165 kg/h for coal; speed of solid material particles within the range 3.71 to 7.97 m/s for coke, and 3.30 to 7.58 m/s for coal; duration of the experiments 0.5 to 1.5 h for coke and 2.0 to 5.0 for coal; angle of inclination of the sample of building material 30 to 60 degrees for both coal and coke breeze. Three types of construction material used in pneumatic transport were tested: steel, concrete and chamotte bricks. Investigations show that concrete is characterized by the highest erosion, chamotte bricks by medium erosion and steel by the lowest erosion. As a result of mathematical processing of experimental data, empirical models of erosion of the three materials are constructed. (7 refs.)

  10. Brachytherapy of choroidal melanomas

    International Nuclear Information System (INIS)

    Brady, L.W.; Hernandez, J.C.

    1992-01-01

    In a compilation of nine reported series consisting of 2,024 enucleations, the five- and ten-year survivals following surgery were 63% and 43%, respectively. The 25-year survival has been reported to be 40%. In 1974 at Wills Eye Hospital and Hahnemann University, the cobalt-60 plaques technique was introduced. During the following years, other radioactive isotopes were introduced including irridium-192, iodine-125, ruthenium-106/rhodium-106 and more recently palladium-103. At the present time, iodine-125 is the most widely used radionuclide. Until now, 302 patients treated with plaque brachytherapy showed an actuarial survival of 77% and 67.8% at five and eight years, respectively. There was no significant survival difference when compared with a similar group of patients undergoing enucleation. Other retrospective studies show similar excellent results. In spite of these convincing results, the decision making process in management melanoma remains unsettled primarily due to the absence of prospective randomized trials. Because of this, the Collaborative Ocular Melanoma Study was initiated. From the standpoint of toxicity, the data are available on ocular radiation toxicity. In an analysis of 77 patients from the Wills Eye Hospital with pretreatment visual acuities of 20/25 or better, it was noted that 90% of patients who had received less than 500 Gy to the fovea retained visual acuity of 20/200 or better while only 52% of patients receiving more than 5,000 Gy to the fovea had vision of 20/200 or better. A serious late effect of radioactivity plaque treatment is scleral necrosis which may require repair or enucleation even in the absence of tumor progression. Enucleation may be necessary in approximately 10% of patients. We conclude that malignant melanoma of the uvea can be safely treated with radioactive plaques. (orig./MG) [de

  11. Preventing Melanoma PSA (:60)

    Centers for Disease Control (CDC) Podcasts

    2015-06-02

    This 60 second public service announcement is based on the June 2015 CDC Vital Signs report. Skin cancer is the most common form of cancer in the U.S. In 2011, there were more than 65,000 cases of melanoma, the most deadly form of skin cancer. Learn how everyone can help prevent skin cancer.  Created: 6/2/2015 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 6/2/2015.

  12. Effectiveness of applying flipped learning to clinical nursing practicums for nursing students in Korea: A randomized controlled trial.

    Science.gov (United States)

    Kim, Hyun Sook; Kim, Mi Young; Cho, Mi-Kyoung; Jang, Sun Joo

    2017-10-01

    The purpose of this study was to develop flipped learning models for clinical practicums and compare their effectiveness regarding learner motivation toward learning, satisfaction, and confidence in performing core nursing skills among undergraduate nursing students in Korea. This study was a randomized clinical trial designed to compare the effectiveness of 2 flipped learning models. Data were collected for 3 days from October 21 to 23, 2015 before the clinical practicum was implemented and for 2 weeks from October 26 to December 18, 2015 during the practicum period. The confidence of the students in performing core nursing skills was likely to increase after they engaged in the clinical practicum in both study groups. However, while learner confidence and motivation were not affected by the type of flipped learning, learner satisfaction did differ between the 2 groups. The findings indicate that applying flipped learning allows students to conduct individualized learning with a diversity of clinical cases at their own level of understanding and at their own pace before they participate in real-world practicums. © 2017 John Wiley & Sons Australia, Ltd.

  13. Effectiveness of a mobile cooperation intervention during the clinical practicum of nursing students: a parallel group randomized controlled trial protocol.

    Science.gov (United States)

    Strandell-Laine, Camilla; Saarikoski, Mikko; Löyttyniemi, Eliisa; Salminen, Leena; Suomi, Reima; Leino-Kilpi, Helena

    2017-06-01

    The aim of this study was to describe a study protocol for a study evaluating the effectiveness of a mobile cooperation intervention to improve students' competence level, self-efficacy in clinical performance and satisfaction with the clinical learning environment. Nursing student-nurse teacher cooperation during the clinical practicum has a vital role in promoting the learning of students. Despite an increasing interest in using mobile technologies to improve the clinical practicum of students, there is limited robust evidence regarding their effectiveness. A multicentre, parallel group, randomized, controlled, pragmatic, superiority trial. Second-year pre-registration nursing students who are beginning a clinical practicum will be recruited from one university of applied sciences. Eligible students will be randomly allocated to either a control group (engaging in standard cooperation) or an intervention group (engaging in mobile cooperation) for the 5-week the clinical practicum. The complex mobile cooperation intervention comprises of a mobile application-assisted, nursing student-nurse teacher cooperation and a training in the functions of the mobile application. The primary outcome is competence. The secondary outcomes include self-efficacy in clinical performance and satisfaction with the clinical learning environment. Moreover, a process evaluation will be undertaken. The ethical approval for this study was obtained in December 2014 and the study received funding in 2015. The results of this study will provide robust evidence on mobile cooperation during the clinical practicum, a research topic that has not been consistently studied to date. © 2016 John Wiley & Sons Ltd.

  14. Dermoscopy of melanoma and non-melanoma skin cancer.

    Science.gov (United States)

    Babino, G; Lallas, A; Longo, C; Moscarella, E; Alfano, R; Argenziano, G

    2015-10-01

    Skin cancer is a major health problem because of its high incidence in white populations, as well as its related potential morbidity and mortality. Dermoscopy is a noninvasive tool that allows the identification of specific morphological features in different skin tumors, improving significantly the early diagnosis of melanoma and non-melanoma skin cancer (NMSC). This tool has also gained increased interest in the management of NMSC therapy and in the post-treatment follow-up. In this article, we provide a review of the dermoscopic patterns and criteria for the diagnosis of melanoma and NMSC described until now in the literature.

  15. Dogmatism, Locus of Control, Perceived Counselor Self-Efficacy, and the Theoretical Orientation of Students in a Master's Level Counseling Practicum

    Science.gov (United States)

    Benesh, Andrew Christopher

    2017-01-01

    Purpose: The purpose of this study was to fill a gap in the literature by examining the relationship between dogmatism, locus of control, counselor self-efficacy, and counselor theoretical orientation in a sample of master's level practicum students. Method: A total of 45 master's practicum students completed a series of four instruments, the DOG…

  16. The Epistemography of an Urban and Regional Planning Practicum: Appropriation in the Face of Resistance. WCER Working Paper No. 2010-8

    Science.gov (United States)

    Bagley, Elizabeth

    2010-01-01

    In this paper, the author describes an ethnographic study of a graduate-level practicum at a large Midwestern university in order to examine one of the ways urban planners develop expertise. The graduate students in the practicum were guided in the production of a site plan for a developing area by a planner with 34 years of planning experience.…

  17. [Formula: see text]Official Position of the American Academy of Clinical Neuropsychology (AACN): Guidelines for Practicum Training in Clinical Neuropsychology.

    Science.gov (United States)

    Nelson, Aaron P; Roper, Brad L; Slomine, Beth S; Morrison, Chris; Greher, Michael R; Janusz, Jennifer; Larson, Jennifer C; Meadows, Mary-Ellen; Ready, Rebecca E; Rivera Mindt, Monica; Whiteside, Doug M; Willment, Kim; Wodushek, Thomas R

    2015-01-01

    Practical experience is central to the education and training of neuropsychologists, beginning in graduate school and extending through postdoctoral fellowship. However, historically, little attention has been given to the structure and requirements of practicum training in clinical neuropsychology. A working group of senior-level neuropsychologists, as well as a current postdoctoral fellow, all from a diverse range of settings (The AACN Practicum Guidelines Workgroup), was formed to propose guidelines for practicum training in clinical neuropsychology. The Workgroup reviewed relevant literature and sought input from professional organizations involved in education and training in neuropsychology. The proposed guidelines provide a definition of practicum training in clinical neuropsychology, detail entry and exit criteria across competencies relevant to practicum training in clinical neuropsychology, and discuss the relationship between doctoral training programs and practicum training sites. The proposed guidelines also provide a methodology for competency-based evaluation of clinical neuropsychology practicum trainees and outline characteristics and features that are integral to an effective training environment. Although the guidelines discussed below may not be implemented in their entirety across all clinical neuropsychology practicum training sites, they are consistent with the latest developments in competency-based education.

  18. Regional wind-field study in complex terrain during summer sea-breeze conditions

    International Nuclear Information System (INIS)

    Porch, W.M.; Volker, P.A.; Peterson, K.R.; Weichel, R.L.; Sherman, C.

    1979-01-01

    A regional-scale data base, consisting of wind and temperature data for June and July of 1977, was developed for the greater San Francisco Bay Area and eastward to the Central Valley. Continuous meteorological measurements were made in the area of a windy pass (Patterson Pass) 3 km east of Lawrence Livermore Laboratory. This area was chosen because of its complex terrain and importance as a downwind topographic feature affecting the dispersal of possible accidental atmospheric releases from the Laboratory and as an area of high wind-energy potential. The results of this study provided the following: (1) a data base, including over 50 stations for use in numerical wind-field regional-scale-model validation; (2) characterization of summer sea breese oscillations of approx. 6 and 12 days (this analysis is useful in calculating wind-power persistence and in understanding summer sea-breeze mechanisms in the Bay Area); and (3) successful application of an optical space-averaging wind sensor over a 1-km path across a pass to provide long-path averaged data more suitable for regional, numerical wind-field models with kilometre-size grid elements

  19. Melanoma Surveillance in the US: The Economic Burden of Melanoma

    Centers for Disease Control (CDC) Podcasts

    2011-10-19

    This podcast accompanies the publication of a series of articles on melanoma surveillance in the United States, available in the November supplement edition of the Journal of the American Academy of Dermatology. Dr. Gery Guy, from the CDC’s Division of Cancer Prevention and Control, discusses the economic burden of melanoma.  Created: 10/19/2011 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 10/19/2011.

  20. Superficial melanomas of oral mucous membranes.

    Science.gov (United States)

    Regezi, J A; Hayward, J R; Pickens, T N

    1978-05-01

    In accordance with microscopic and clinical criteria established for superficial melanomas of the skin (superficial spreading melanoma, lentigo maligna melanoma, acral-lentiginous melanoma), three oral lesions have been evaluated. The literature on oral melanomas has also been reviewed, with special attention given to those cases that had pre-existing melanosis. One patient with a diagnosis of superficial spreading melanoma eventually died of his untreated lesion 11 years after its first appearance. Two patients had lesions diagnosed as acral-lentiginous melanoma (a group which also includes volar and subungual melanomas) that exhibited aggressive, recurrent behavior. These lesions had microsocpic features similar to lentigo maligna melanoma but did not behave in a manner consistent with that diagnosis. Electron microscopic study of one acral-lentiginous melanoma demonstrated malenosomes and premelanosomes that were like those seen in normal melanocytes and nevus cells. The superficial or radial growth phase of many oral melanomas has apparently gone unrecognized. Melanosis has been reported to be a common feature of invasive oral melanomas but has not generally been related to the natural history of these lesions. Oral lesions with a prolonged intra-epithelial or radial growth phase would be expected to have a better prognosis than nodular melanomas, but meaningful survival data are not available because of the infrequency with which oral melanomas have been subclassified.

  1. Primary dermal melanoma: a West Australian cohort.

    Science.gov (United States)

    Teow, James; Chin, Olivia; Hanikeri, Mark; Wood, Benjamin A

    2015-09-01

    The objectives of this study were to identify a subgroup of patients with putative primary dermal melanoma after thorough multidisciplinary clinical and histological evaluation, and to describe the clinical, histological and selected molecular features of these lesions. The records of the Western Australian Melanoma Advisory Service were searched for potential cases of primary dermal melanoma. The clinical and histological features were reviewed, immunohistochemical assessment was performed and clinical outcomes recorded. Eighteen cases of putative primary dermal melanoma with available clinical data were identified. Two of 12 cases in which further histological sections could be obtained were excluded because of the presence of findings suggesting an epidermal origin on these further sections. In one additional case, such origin could not be histologically excluded. Median follow-up period for the remaining cases was 68 months. Confirmed primary dermal melanoma accounts for 0.87% of cases of melanoma referred to a subspecialist melanoma advisory service. These cases show significant histological overlap with dermal/subcutaneous metastases of melanoma, but display a relatively good prognosis, with a 5-year survival of 87.5%. Our results support the recognition of a distinct group of melanoma that mimics metastatic melanoma, but is associated with a relatively favourable outcome. The group of putative primary dermal melanoma is likely to be heterogenous, including cases of primary nodular melanoma in which epidermal connection has not been identified, metastatic melanoma with an occult primary lesion and true primary dermal melanoma. © 2015 Royal Australasian College of Surgeons.

  2. Melanoma of the skin in the Danish Cancer Registry and the Danish Melanoma Database

    DEFF Research Database (Denmark)

    Pedersen, Sidsel Arnspang; Schmidt, Sigrun Alba Johannesdottir; Klausen, Siri

    2018-01-01

    BACKGROUND: The nationwide Danish Cancer Registry and the Danish Melanoma Database both record data on melanoma for purposes of monitoring, quality assurance and research. However, the data quality of the Cancer Registry and the Melanoma Database has not been formally evaluated. METHODS: We...... estimated the positive predictive value (PPV) of melanoma diagnosis for random samples of 200 patients from the Cancer Registry (n=200) and the Melanoma Database (n=200) during 2004-2014, using the Danish Pathology Registry as 'gold-standard' reference. We further validated tumor characteristics...... in the Cancer Registry and the Melanoma Database. Additionally, we estimated the PPV of in situ melanoma diagnoses in the Melanoma Database, and the sensitivity of melanoma diagnoses in 2004-2014. RESULTS: The PPVs of melanoma in the Cancer Registry and the Melanoma Database were 97% (95% CI, 94-99) and 100...

  3. High accuracy of family history of melanoma in Danish melanoma cases

    DEFF Research Database (Denmark)

    Wadt, Karin A W; Drzewiecki, Krzysztof T; Gerdes, Anne-Marie

    2015-01-01

    The incidence of melanoma in Denmark has immensely increased over the last 10 years making Denmark a high risk country for melanoma. In the last two decades multiple public campaigns have sought to increase the awareness of melanoma. Family history of melanoma is a known major risk factor...... but previous studies have shown that self-reported family history of melanoma is highly inaccurate. These studies are 15 years old and we wanted to examine if a higher awareness of melanoma has increased the accuracy of self-reported family history of melanoma. We examined the family history of 181 melanoma...... probands who reported 199 cases of melanoma in relatives, of which 135 cases where in first degree relatives. We confirmed the diagnosis of melanoma in 77% of all relatives, and in 83% of first degree relatives. In 181 probands we validated the negative family history of melanoma in 748 first degree...

  4. Podoplanin Expression in Canine Melanoma.

    Science.gov (United States)

    Ogasawara, Satoshi; Honma, Ryusuke; Kaneko, Mika K; Fujii, Yuki; Kagawa, Yumiko; Konnai, Satoru; Kato, Yukinari

    2016-12-01

    A type I transmembrane protein, podoplanin (PDPN), is expressed in several normal cells such as lymphatic endothelial cells or pulmonary type I alveolar cells. We recently demonstrated that anticanine PDPN monoclonal antibody (mAb), PMab-38, recognizes canine PDPN of squamous cell carcinomas, but does not react with lymphatic endothelial cells. Herein, we investigated whether PMab-38 reacts with canine melanoma. PMab-38 reacted with 90% of melanoma cells (9/10 cases) using immunohistochemistry. Of interest, PMab-38 stained the lymphatic endothelial cells and cancer-associated fibroblasts in melanoma tissues, although it did not stain any lymphatic endothelial cells in normal tissues. PMab-38 could be useful for uncovering the function of PDPN in canine melanomas.

  5. Podoplanin Expression in Canine Melanoma

    OpenAIRE

    Ogasawara, Satoshi; Honma, Ryusuke; Kaneko, Mika K.; Fujii, Yuki; Kagawa, Yumiko; Konnai, Satoru; Kato, Yukinari

    2016-01-01

    A type I transmembrane protein, podoplanin (PDPN), is expressed in several normal cells such as lymphatic endothelial cells or pulmonary type I alveolar cells. We recently demonstrated that anticanine PDPN monoclonal antibody (mAb), PMab-38, recognizes canine PDPN of squamous cell carcinomas, but does not react with lymphatic endothelial cells. Herein, we investigated whether PMab-38 reacts with canine melanoma. PMab-38 reacted with 90% of melanoma cells (9/10 cases) using immunohistochemistr...

  6. Case studies of skin melanoma

    Directory of Open Access Journals (Sweden)

    A. V. Kozlova

    2015-01-01

    Full Text Available Skin melanoma is a malignant tumor originating in the cells of the melanocytic system, which is characterized by an aggressive clinical course, significant metastatic potential and unfavorable prognosis. These features of the tumor stipulate the need to improve measures to optimize early diagnosis of tumors. The article presents cases of pigmented skin melanoma to demonstrate the variability of clinical manifestations of this tumor requiring dermatologist skills in the differential diagnostics of neoplasms.

  7. [Choroidal melanoma - evolution and prognosis].

    Science.gov (United States)

    Chiruţa, Daria; Stan, Cristina

    2014-01-01

    Choroidal melanoma is the most common primary intraocular malignant tumor. We present the case of a 62 year old patient who was diagnosed with intraocular tumor in his right eye, for about three years. Regarding the fact that the patient refused any kind of treatment during this period, we just had the opportunity to monitor this case. Finally, the diagnosis was choroidal melanoma, confirmed by the histopathological exam.

  8. Umbilicus reconstruction after melanoma excision

    Directory of Open Access Journals (Sweden)

    Miguel Costa-Silva

    2017-01-01

    Full Text Available An 81-year-old woman was admitted with a nodular cutaneous melanoma of the abdominal wall involving the umbilicus. After performing wide excision with 2 cm margin of the melanoma, umbilical reconstruction and defect closure were planned. After careful consideration, we decided to use an island pedicle flap which allowed closure of the defect and reconstruction of the umbilicus.

  9. Uma teoria termodinâmica para brisas: teste utilizando simulações numéricas A thermodynamic theory for breezes: test using numeric simulations

    Directory of Open Access Journals (Sweden)

    Clênia Rodrigues Alcântara

    2008-03-01

    Full Text Available O objetivo deste trabalho foi testar uma teoria termodinâmica em brisas marítimas-terrestres acopladas com brisas de vale-montanha através de simulações numéricas tridimensionais em uma região da costa leste do Nordeste Brasileiro, considerando a presença e a ausência da topografia. Embora o contraste de temperatura entre as superfícies seja importante na formação da brisa, a eficiência termodinâmica é fundamental na determinação da sua intensidade. Tem-se que a inclinação faz com que a diferença de pressão entre dois pontos fique maior durante o dia e menor durante a noite contribuindo para a formação de brisas marítimas mais intensas e de brisas terrestres menos intensas, respectivamente. A máxima queda de pressão ocorre por volta de três horas antes da máxima intensidade da brisa. Isso porque grande parte da energia disponibilizada para as circulações é gasta para vencer dissipação, principalmente, no período diurno, quando esses processos são realmente efetivos. Do ponto de vista puramente termodinâmico a inclinação da montanha atua para intensificar a brisa durante o dia e para enfraquecê-la durante a noite.In this work we test a thermodynamic theory for sea-land breeze coupled with valley-mountain breeze through tri-dimensional numeric simulations. We verify the presence of such a breeze in Northeast Brazil's east coast and perform experiments with and without the topography of the region. Although the temperature contrast between two surfaces is important in forming the breezes, the thermodynamic efficiency is a key parameter for the breeze intensity. The presence of the slope causes the pressure difference between two points to increase during the day and to decrease during the night. This contributes for more intense daytime breeze and less intense nighttime ones. The maximum pressure drop occurs about three hours prior the maximum intensity of the sea breeze. This is because most of the available

  10. Sea breeze development under an offshore synoptic wind in the South-Western Cape and implications for the Stellenbosch wine-producing area

    Science.gov (United States)

    Bonnardot, V.; Planchon, O.; Cautenet, S.

    2005-07-01

    Sea breezes were investigated during the maturation period of wine grapes in the South-Western Cape under particular synoptic wind conditions (onshore for Table Bay and offshore for False Bay). Observations from an automatic weather station network located in the Stellenbosch wine-producing area as well as the Regional Atmospheric Modelling System (RAMS, non-hydrostatic, parallel, version 4.3) were used. Results showed that two sea breezes developed, one from Table Bay late in the morning, and the other from False Bay later in the afternoon. The coastal low strengthened and deflected the sea breeze from Table Bay towards the south and south-east of the study area, while the offshore large-scale circulation hindered the development of the sea breeze in the opposite direction over False Bay and delayed its movement towards land. The decrease in temperature resulting from the onset of the sea breeze from the Atlantic early in the afternoon could be significant for viticulture, reducing the duration and intensity of high temperature stress on grapevine functioning at the coolest locations.

  11. Surface current dynamics under sea breeze conditions observed by simultaneous HF radar, ADCP and drifter measurements

    Science.gov (United States)

    Sentchev, Alexei; Forget, Philippe; Fraunié, Philippe

    2017-04-01

    Ocean surface boundary layer dynamics off the southern coast of France in the NW Mediterranean is investigated by using velocity observations by high-frequency (HF) radars, surface drifting buoys and a downward-looking drifting acoustic Doppler current profiler (ADCP). The analysis confirms that velocities measured by HF radars correspond to those observed by an ADCP at the effective depth z f = k -1, where k is wavenumber of the radio wave emitted by the radar. The radials provided by the radars were in a very good agreement with in situ measurements, with the relative errors of 1 and 9 % and root mean square (RMS) differences of 0.02 and 0.04 m/s for monostatic and bistatic radar, respectively. The total radar-based velocities appeared to be slightly underestimated in magnitude and somewhat biased in direction. At the end of the survey period, the difference in the surface current direction, based on HF radar and ADCP data, attained 10°. It was demonstrated that the surface boundary layer dynamics cannot be reconstructed successfully without taking into the account velocity variation with depth. A significant misalignment of ˜30° caused by the sea breeze was documented between the HF radar (HFR-derived) surface current and the background current. It was also found that the ocean response to a moderate wind forcing was confined to the 4-m-thick upper layer. The respective Ekman current attained the maximum value of 0.15 m/s, and the current rotation was found to be lagging the wind by approximately 40 min, with the current vector direction being 15-20° to the left of the wind. The range of velocity variability due to wind forcing was found comparable with the magnitude of the background current variability.

  12. Ubiquitination in melanoma pathogenesis and treatment.

    Science.gov (United States)

    Ma, Jinyuan; Guo, Weinan; Li, Chunying

    2017-06-01

    Melanoma is one of the most aggressive skin cancers with fiercely increasing incidence and mortality. Since the progressive understanding of the mutational landscape and immunologic pathogenic factors in melanoma, the targeted therapy and immunotherapy have been recently established and gained unprecedented improvements for melanoma treatment. However, the prognosis of melanoma patients remains unoptimistic mainly due to the resistance and nonresponse to current available drugs. Ubiquitination is a posttranslational modification which plays crucial roles in diverse cellular biological activities and participates in the pathogenesis of various cancers, including melanoma. Through the regulation of multiple tumor promoters and suppressors, ubiquitination is emerging as the key contributor and therefore a potential therapeutic target for melanoma. Herein, we summarize the current understanding of ubiquitination in melanoma, from mechanistic insights to clinical progress, and discuss the prospect of ubiquitination modification in melanoma treatment. © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

  13. The role of nitric oxide in melanoma.

    Science.gov (United States)

    Yarlagadda, Keerthi; Hassani, John; Foote, Isaac P; Markowitz, Joseph

    2017-12-01

    Nitric oxide (NO) is a small gaseous signaling molecule that mediates its effects in melanoma through free radical formation and enzymatic processes. Investigations have demonstrated multiple roles for NO in melanoma pathology via immune surveillance, apoptosis, angiogenesis, melanogenesis, and on the melanoma cell itself. In general, elevated levels of NO prognosticate a poor outcome for melanoma patients. However, there are processes where the relative concentration of NO in different environments may also serve to limit melanoma proliferation. This review serves to outline the roles of NO in melanoma development and proliferation. As demonstrated by multiple in vivo murine models and observations from human tissue, NO may promote melanoma formation and proliferation through its interaction via inhibitory immune cells, inhibition of apoptosis, stimulation of pro-tumorigenic cytokines, activation of tumor associated macrophages, alteration of angiogenic processes, and stimulation of melanoma formation itself. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Tool to Distinguish Moles from Melanoma

    Science.gov (United States)

    “Moles to Melanoma: Recognizing the ABCDE Features” presents photos that show changes in individual pigmented lesions over time, and describes the different appearances of moles, dysplastic nevi, and melanomas.

  15. [Selecting methods and awaiting growth: the teaching experience of fundamental nursing practicum instructors].

    Science.gov (United States)

    Lin, Hui-Chen; Lin, Chi-Yi; Chien, Tsui-Wei; Liu, Kuei-Fen; Chen, Miao-Yen; Lin, Wen-Chuan

    2013-02-01

    A constellation of factors accounts for teaching efficacy in the fundamental nursing practicum. Teachers play a critical role in terms of designing and executing an appropriate teaching plan, choosing effective methods, and holding appropriate teaching attitudes. It is thus extremely important that clinical teachers master the core characteristics of basic nursing practice. This study aimed to illuminate the core characteristics of basic nursing practice for students for reference by clinical practicum teachers. Qualitative research was used to identify the fundamentals of nursing practice by clinical teacher. Five focus group meetings were convened during the practice period. The researchers presided over group discussions held during the normal weekly teaching schedule and lasting approximately 2-4 hours each. The content analysis was adopted to analyze the data. Three major themes were proposed, including (1) student status: "novices were stymied by problems and thus improved slowly"; (2) teacher awareness: "teachers need to be aware of student capabilities, mood, and discomfort"; and (3) teaching style: "a good choice of methods should support and encourage students. To cultivate professional nursing knowledge and self-confidence for future professional commitment, clinical teachers must first understand the characteristics and motivations of learning of their students and then select the, skills, and attitudes appropriate to provide step-by-step guidance. Communication with staffs and the preparation of atmosphere prior to nursing practice are also essential for students. Results provide insights into the technical college environment with regard to basic-level clinical nursing practice.

  16. Learning to be a midwife in the clinical environment; tasks, clinical practicum hours or midwifery relationships.

    Science.gov (United States)

    Ebert, Lyn; Tierney, Olivia; Jones, Donovan

    2016-01-01

    Discussions continue within the midwifery profession around the number of and type of clinical experiences required to ensure competent midwifery graduates. Introduction of the three year Bachelor of Midwifery in Australia, almost two decades ago, was intended to reduce the pressure students were under to complete their academic requirements whilst ensuring students developed midwifery practice that encapsulates the philosophical values of midwifery. Currently, midwifery students are mandated to achieve a minimum number of clinical skills and Continuity of Care Experience (CCE) relationships in order to register upon completion of their degree. To achieve these experiences, universities require students to complete a number of clinical practicum hours. Furthermore students are required to demonstrate competent clinical performance of a number of clinical skills. However, there is no evidence to date that a set number of experiences or hours ensures professional competence in the clinical environment. The aim of this paper is to promote discussion regarding the mandated requirements for allocated clinical practicum hours, specified numbers of clinical-based skills and CCE relationships in the context of learning to be a midwife in Australia. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Large melanoma metastases to the gastrointestinal tract.

    OpenAIRE

    Silverman, J M; Hamlin, J A

    1989-01-01

    It is well known that malignant melanoma can metastasize widely. Although these metastases in the gastrointestinal tract usually appear as small 'bull's-eye' or 'target' lesions, there are a few reports of relatively large melanoma metastases. We report five cases of large melanoma lesions metastatic to the alimentary canal. We also emphasise the consideration of a thorough gastrointestinal tract evaluation in patients with malignant melanoma especially if they are symptomatic.

  18. Unusual presentations of melanoma: melanoma of unknown primary site, melanoma arising in childhood, and melanoma arising in the eye and on mucosal surfaces.

    Science.gov (United States)

    Sondak, Vernon K; Messina, Jane L

    2014-10-01

    Most melanomas present as primary tumors on the skin surface in adults; however, melanomas also arise in the eye and on the mucosal surfaces or present as apparently metastatic disease without any known history of a cutaneous primary. Melanoma is also being diagnosed during childhood more frequently than ever. Surgeons need to be aware of and understand these unusual presentations of melanoma to optimally manage their patients. Copyright © 2014 Elsevier Inc. All rights reserved.

  19. Short range forecasting of sea breeze generated thunderstorms at the Kennedy Space Center: A real-time experiment using a primitive equation mesoscale numerical model

    Science.gov (United States)

    Lyons, Walter A.; Schuh, Jerome A.; Moon, Dennis; Pielke, Roger A.; Cotton, William; Arritt, Raymond

    1987-01-01

    The operational efficiency of using guidance from a mesoscale numerical model to improve sea breeze thunderstorm forecasts at and around the Shuttle landing strip was assessed. The Prognostic Three-Dimensional Mesoscale (P3DM) model, developed as a sea breeze model, reveals a strong correlation between regions of mesoscale convergence and the triggering of sea breeze convection thunderstorms. The P3DM was modified to generate stability parameters familiar to the operational forecaster. In addition to the mesoscale fields of wind, vertical motion, moisture, temperature, a stability indicator, a combination of model-predicted K and Lifted Indices and the maximum grid cell vertical motion, were proposed and tested. Results of blind tests indicate that a forecaster, provided with guidance derived from model output, could improve local thunderstorm forecasts.

  20. Teaching Practicum Assessment in Post-Apartheid Teacher Education: Is It Self-Serving or Serving Students?

    Science.gov (United States)

    Davids, M. Noor

    2015-01-01

    This article investigates common understandings and practices of a group of supervisors assessing students during the Teaching Practicum in South Africa. In the light of this context and the need for a constructivist approach to develop students to be able to teach in diverse contexts, the question that the research intends to answer is as…

  1. The Practical Source of Educational Knowledge for Pre-Service Teachers in Confronting Field-Based Challenges in School Practicum

    Science.gov (United States)

    Tsai, Hsien-Chang; Liu, Shih-Hsiung

    2013-01-01

    Educational value in teacher education courses is unquestioned; however, there are still many doubts about the practicality of the knowledge acquired from university courses and a field-based course in school practicum. The purpose of this study is to identify the practicality of the educational knowledge from the above courses for pre-service…

  2. A Critical Look at a Blended English Language Teacher Education Program with an Emphasis on the Practicum

    Science.gov (United States)

    Koç, Ebru Melek

    2016-01-01

    The aim of the present study was to explore what types of difficulties student teachers enrolled in a Bachelor of Arts (B.A.) in English Language Teacher Education program offered in a blended format and their cooperating teachers encountered during the student teacher practicum. The participants were 21 fourth grade student teachers and 12…

  3. Practicum as a Space and Time of Transformation: Self-Narrative of a Physical Education Pre-Service Teacher

    Science.gov (United States)

    Margarida, Alves; Ana, Pereira; Amandio, Graca; Paula, Batista

    2012-01-01

    Understanding the role of the practicum in the PI (professional identity) construction and reconstruction within a pre-service teacher is crucial, since this is a remarkable moment in their initial training. This moment provides new feelings and challenges, and it represents the transition from students (pre-service teacher) to teachers…

  4. Articulating Learning Objectives for an Undergraduate Teaching Assistant Program: Merging Teaching Practicum, Leadership Seminar, and Service Learning

    Science.gov (United States)

    Murray, Jeffrey W.

    2015-01-01

    Since its inception in 2009, the Undergraduate Teaching Assistant Program (in the Department of Focused Inquiry at Virginia Commonwealth University) has evolved and expanded into an amalgamation of three distinct but overlapping elements: (i) teaching practicum, (ii) leadership seminar, and (iii) service learning experience. But only recently have…

  5. An Investigation of Preservice Early Childhood Teachers' Adoption of ICT in a Teaching Practicum Context in Hong Kong

    Science.gov (United States)

    Hu, Xinyun; Yelland, Nicola

    2017-01-01

    The research reported here investigated the use of information and communication technologies (ICT) by 15 Hong Kong preservice early childhood teachers (PSTs) who had completed a course regarding the use of ICT in early childhood settings as they participated in their first-year teaching practicum. The study examined the preservice teachers use of…

  6. Investigating Pre-Service EFL Teachers' Self-Concepts within the Framework of Teaching Practicum in Turkish Context

    Science.gov (United States)

    Yilmaz, Cevdet

    2018-01-01

    The present study aimed at understanding the nature and potential dynamism of five pre-service EFL teachers' self-concepts in the domain of English as a foreign language (EFL). To this end, the effects of pre-service teachers' experiences gained alongside the practicum on their EFL self-concept development were also discussed. Data were generated…

  7. "Baby Teachers": How Pre-Service Early Childhood Students Transform Their Conceptions of Teaching and Learning through an Infant Practicum

    Science.gov (United States)

    Recchia, Susan L.; Shin, Minsun

    2010-01-01

    This qualitative study explores how working with infants changed pre-service early childhood students' thinking about important aspects of early childhood education. Through a qualitative analysis of four pre-service early childhood students' weekly dialogue journals during a required, one-semester infant practicum, the authors discovered how the…

  8. Cross-Cultural "Distance", "Friction" and "Flow": Exploring the Experiences of Pre-Service Teachers on International Practicum

    Science.gov (United States)

    Uusimaki, Liisa; Swirski, Teresa

    2016-01-01

    The focus of this paper is to illustrate Australian regional pre-service teachers' perceptions of an international practicum: their cross-cultural understanding, notions of privilege and teacher/professional identity development. Findings indicate that there were three overlapping dimensions of cross-cultural understanding for pre-service…

  9. The Efficacy of Consulting Practicum in Enhancing Students' Readiness for Professional Career in Management Information Systems: An Empirical Analysis

    Science.gov (United States)

    Akpan, Ikpe Justice

    2016-01-01

    Consulting practicum (CP) is a form of experiential learning technique to prepare students for professional careers. While CP has become a popular way to help students acquire the essential practical skills and experience to enhance career readiness and ensure a smooth transition from college to employment, there is a lack of empirical studies…

  10. Investigating the Stress Levels of Early Childhood, Primary and Secondary Pre-Service Teachers during Teaching Practicum

    Science.gov (United States)

    Geng, Gretchen; Midford, Richard; Buckworth, Jenny

    2015-01-01

    This study investigated stress levels of pre-service teachers (PSTs) across three categories of teaching context: early childhood, primary and secondary. This paper focused on exploring the stressors in the completion of tasks in teaching practicum in the three categories of teaching context and an awareness of and access to support systems. The…

  11. Nursing students' perception of academic support in the practicum: Development of a reliable and valid measurement instrument.

    Science.gov (United States)

    Arribas-Marín, Juan; Hernández-Franco, Vicente; Plumed-Moreno, Calixto

    The importance of practicum training in health sciences disciplines places prominence on the academic support received by students in this learning environment, both due to its leverage over their perceived level of satisfaction of academic proficiency as well as its impact on their academic performance. The aim of this study was to develop and validate a scale which facilitates the evaluation of academic support perceived by nursing students during their practicum. The sample is made up of 710 students from three academic levels of the Bachelor's Degree in Nursing. An instrument to evaluate the level of academic support perceived by the students was developed and validated. Subsequently, a measurement model of the dimensions which comprise the academic support in the practicum was created. The Academic Support in the Practicum Scale demonstrated high internal consistency, with a Cronbach's alpha value=0.913. The validation of the measurement instrument was carried out using confirmatory factor analysis and multi-sample analysis techniques, which presented positive goodness-of-fit indices. The developed tool has shown sufficient validity and high internal consistency. Its adequate psychometric properties lead to the conclusion that the scale provides a reliable and valid measurement of academic support perceived by students during their placement. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Pregnancy and early-stage melanoma

    NARCIS (Netherlands)

    Daryanani, D; Plukker, JT; De Hullu, JA; Kuiper, H; Nap, RE; Hoekstra, HJ

    2003-01-01

    BACKGROUND. Cutaneous melanomas are aggressive tumors with an unpredictable biologic behavior. It has been suggested that women who present with melanoma during pregnancy have a worse prognosis due to more aggressive behavior of the melanoma. The objective of the current study was to evaluate the

  13. Clinicopathological and molecular aspects of cutaneous Melanoma

    NARCIS (Netherlands)

    Bogenrieder, T.

    2009-01-01

    Clinicopathological and molecular aspects of cutaneous melanoma. Melanoma arises form the transformation of neural crest-derived melanocytes, the pigment cells of the skin, which reside in the basal layer of the epidermis. Melanoma is the deadliest form of skin cancer and one of the most aggressive

  14. Genetic prognostic factors in uveal melanoma

    NARCIS (Netherlands)

    Maat, Willem

    2012-01-01

    Uveal melanoma (UM) is the most common malignancy of the eye in adults and it is the second most common form of melanoma after cutaneous melanoma (CM). The identification of patients who have a high risk of developing metastases would allow the possibility of providing adjuvant therapies to prevent

  15. Melanoma continues to rise throughout the world

    African Journals Online (AJOL)

    Review Article: Melanoma continues to rise throughout the world. 530 ... of melanoma. The radiation in the ultraviolet B range is said to be the critical component. Generally, worldwide, the incidence of melanoma in white people4,5 correlates inversely with .... lymphocytes, mitotic rate, regression, angiolymphatic invasion ...

  16. Decreased tumor-infiltrating lymphocytes in nodular melanomas compared with matched superficial spreading melanomas.

    Science.gov (United States)

    Lin, Richard L; Wang, Thomas J; Joyce, Cara J; Mihm, Martin C; Murphy, George F; Lian, Christine G; Lin, Jennifer Y

    2016-10-01

    Melanoma causes over 9000 deaths annually in the USA. Among its subtypes, nodular melanoma leads to a disproportionate number of fatalities compared with superficial spreading melanoma, the most common subtype. Recent breakthroughs in melanoma research have indicated a strong connection between melanoma virulence and the immune system. We hypothesize that the aggression of nodular melanoma may, in part, be because of decreased recognition by the immune system, as represented by a decreased presence of tumor-infiltrating lymphocytes (TILs), compared with its superficial spreading counterpart. Indeed, TILs on a primary melanoma have been used as a marker for immune response and have prognostic value for survival and sentinel lymph node status. After matching melanoma cases by age, sex, and Breslow thickness, we found significantly fewer TILs in nodular melanomas than in superficial spreading melanomas. This association was prominent in thin (≤2 mm) melanomas and was no longer significant in thick (>2 mm) melanomas. In addition, this difference in TILs was only present in men and not in women. Our finding suggests that nodular melanomas are more frequently associated with absent TILs, providing an avenue for further investigation into differences in immunogenicity of the primary melanoma and whether they underlie the unique virulence of nodular melanoma.

  17. Emerging targeted therapies for melanoma.

    Science.gov (United States)

    Johnson, Douglas B; Pollack, Megan H; Sosman, Jeffrey A

    2016-06-01

    Melanoma is an aggressive cutaneous malignancy associated with poor response to traditional therapies. Recent regulatory approval for immune checkpoint inhibitors and agents targeting mutated BRAF has led to a tremendous expansion of effective treatment options for patients with advanced melanoma. Unfortunately, primary or acquired resistance develops in most patients, highlighting the need for additional therapies. Numerous genetic and other molecular features of this disease may provide effective targets for therapy development. This article reviews available melanoma treatments, including immune and molecularly-targeted therapies. We then discuss agents in development, with a focus on targeted (rather than immune) therapies. In particular, we discuss agents that block mitogen-activated protein kinase (MAPK) signaling, as well as other emerging approaches such as antibody-drug conjugates, cell-cycle targeting, and novel genetically-informed clinical trials. Despite the incredible advances in melanoma therapeutics over the last several years, a clear need to develop more effective therapies remains. Molecularly-targeted therapy approaches will likely remain a cornerstone of melanoma treatment in parallel to immune therapy strategies.

  18. Current systemic therapies for melanoma.

    Science.gov (United States)

    Palathinkal, Darren M; Sharma, Timmie R; Koon, Henry B; Bordeaux, Jeremy S

    2014-09-01

    Systemic agents are used in melanoma for adjuvant therapy and to treat metastatic disease. Currently, interferon-α is the only agent approved for adjuvant therapy. Six drugs are FDA approved for metastatic disease: dacarbazine, interleukin-2 (IL-2), vemurafenib, ipilimumab, dabrafenib, and trametinib. Vemurafenib and ipilimumab were approved in 2011, whereas dabrafenib and trametinib were approved in 2013. This review will update the practicing dermatologist on the differences in efficacy, adverse events, and cost of systemic therapies available for the treatment of melanoma. This article is a review of the current literature on systemic therapies for advanced melanoma. Key search words included "advanced melanoma," "systemic therapy," and "adjuvant therapy" with particular focus on the past 20 years. Before 2011, dacarbazine and IL-2 were the only FDA approved therapies for metastatic melanoma, and IFN-α is the only approved agent for adjuvant therapy. The new agents vemurafenib, ipilimumab, dabrafenib, and trametinib are the first to have improved overall survival in Phase III studies in comparison with other systemic therapies. Despite new developments, there remains a significant need for better therapies with improved long-term efficacy and decreased toxicity.

  19. Other targeted drugs in melanoma.

    Science.gov (United States)

    González-Cao, María; Rodón, Jordi; Karachaliou, Niki; Sánchez, Jesús; Santarpia, Mariacarmela; Viteri, Santiago; Pilotto, Sara; Teixidó, Cristina; Riso, Aldo; Rosell, Rafael

    2015-10-01

    Targeted therapy drugs are developed against specific molecular alterations on cancer cells. Because they are "targeted" to the tumor, these therapies are more effective and better tolerated than conventional therapies such as chemotherapy. In the last decade, great advances have been made in understanding of melanoma biology and identification of molecular mechanisms involved in malignant transformation of cells. The identification of oncogenic mutated kinases involved in this process provides an opportunity for development of new target therapies. The dependence of melanoma on BRAF-mutant kinase has provided an opportunity for development of mutation-specific inhibitors with high activity and excellent tolerance that are now being used in clinical practice. This marked a new era in the treatment of metastatic melanoma and much research is now ongoing to identify other "druggable" kinases and transduction signaling networking. It is expected that in the near future the spectrum of target drugs for melanoma treatment will increase. Herein, we review the most relevant potential novel drugs for melanoma treatment based on preclinical data and the results of early clinical trials.

  20. Melanoma stem cells in experimental melanoma are killed by radioimmunotherapy

    International Nuclear Information System (INIS)

    Jandl, Thomas; Revskaya, Ekaterina; Jiang, Zewei; Harris, Matthew; Dorokhova, Olena; Tsukrov, Dina; Casadevall, Arturo; Dadachova, Ekaterina

    2013-01-01

    Introduction: In spite of recently approved B-RAF inhibitors and immunomodulating antibodies, metastatic melanoma has poor prognosis and novel treatments are needed. Melanoma stem cells (MSC) have been implicated in the resistance of this tumor to chemotherapy. Recently we demonstrated in a Phase I clinical trial in patients with metastatic melanoma that radioimmunotherapy (RIT) with 188-Rhenium( 188 Re)-6D2 antibody to melanin was a safe and effective modality. Here we investigated the interaction of MSC with RIT as a possible mechanism for RIT efficacy. Methods: Mice bearing A2058 melanoma xenografts were treated with either 1.5 mCi 188 Re-6D2 antibody, saline, unlabeled 6D2 antibody or 188 Re-labeled non-specific IgM. Results: On Day 28 post-treatment the tumor size in the RIT group was 4-times less than in controls (P < 0.001). The tumors were analyzed by immunohistochemistry and FACS for two MSC markers — chemoresistance mediator ABCB5 and H3K4 demethylase JARID1B. There were no significant differences between RIT and control groups in percentage of ABCB5 or JARID1B-positive cells in the tumor population. Our results demonstrate that unlike chemotherapy, which kills tumor cells but leaves behind MSC leading to recurrence, RIT kills MSC at the same rate as the rest of tumor cells. Conclusions: These results have two main implications for melanoma treatment and possibly other cancers. First, the susceptibility of ABCB5 + and JARID1B + cells to RIT in melanoma might be indicative of their susceptibility to antibody-targeted radiation in other cancers where they are present as well. Second, specifically targeting cancer stem cells with radiolabeled antibodies to ABCB5 or JARID1B might help to completely eradicate cancer stem cells in various cancers

  1. Use of mobile devices in nursing student-nurse teacher cooperation during the clinical practicum: an integrative review.

    Science.gov (United States)

    Strandell-Laine, Camilla; Stolt, Minna; Leino-Kilpi, Helena; Saarikoski, Mikko

    2015-03-01

    To identify and appraise study findings on the use of mobile devices, in particular for what purposes and how, in nursing student-nurse teacher cooperation during the clinical practicum. A systematic literature search was conducted using the PubMed/Medline, CINAHL, PsycINFO and ERIC for primary empirical studies published in English. An integrative literature review was undertaken. Quality appraisal of the included studies was conducted using design-specific standardized checklists. Studies were thematically analyzed. Based on the inclusion and exclusion criteria, eleven studies were included in the review. Weaknesses in designs, samples, questionnaires and results, compromised comparison and/or generalization of the findings of the studies. Three main themes were identified: (1) features of mobile devices (2) utility of mobile devices and (3) barriers to the use of mobile devices. Problems of connectivity were the main challenges reported in the use of mobile devices. Participants used mobile devices primarily as reference tools, but less frequently as tools for reflection, assessment or cooperation during the clinical practicum. Interest in mobile device use during the clinical practicum was reported, but training and ongoing support are needed. As only a small number of eligible primary empirical studies were found, it is not possible to draw firm conclusions on the results. In the future, rigorous primary empirical studies are needed to explore the potential of mobile devices in providing a supplementary pedagogical method in nursing student-nurse teacher cooperation during the clinical practicum. Robust study designs, including experimental ones, are clearly needed to assess the effectiveness of mobile devices in nursing student-nurse teacher cooperation during the clinical practicum. Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. High accuracy of family history of melanoma in Danish melanoma cases.

    Science.gov (United States)

    Wadt, Karin A W; Drzewiecki, Krzysztof T; Gerdes, Anne-Marie

    2015-12-01

    The incidence of melanoma in Denmark has immensely increased over the last 10 years making Denmark a high risk country for melanoma. In the last two decades multiple public campaigns have sought to increase the awareness of melanoma. Family history of melanoma is a known major risk factor but previous studies have shown that self-reported family history of melanoma is highly inaccurate. These studies are 15 years old and we wanted to examine if a higher awareness of melanoma has increased the accuracy of self-reported family history of melanoma. We examined the family history of 181 melanoma probands who reported 199 cases of melanoma in relatives, of which 135 cases where in first degree relatives. We confirmed the diagnosis of melanoma in 77% of all relatives, and in 83% of first degree relatives. In 181 probands we validated the negative family history of melanoma in 748 first degree relatives and found only 1 case of melanoma which was not reported in a 3 case melanoma family. Melanoma patients in Denmark report family history of melanoma in first and second degree relatives with a high level of accuracy with a true positive predictive value between 77 and 87%. In 99% of probands reporting a negative family history of melanoma in first degree relatives this information is correct. In clinical practice we recommend that melanoma diagnosis in relatives should be verified if possible, but even unverified reported melanoma cases in relatives should be included in the indication of genetic testing and assessment of melanoma risk in the family.

  3. Clear cells in acral melanoma.

    Science.gov (United States)

    Schmuth, M; Spötl, L; Zelger, B; Weinlich, G; Zelger, B

    2001-01-01

    Acral melanoma may present clinically and histologically with atypical features causing a delay in proper diagnosis. The aim of the present study was to assess the frequency of a histological variant with clear cell changes. Clinical information, hematoxylin & eosin stained paraffin sections and immunohistochemical staining profiles were reviewed in 49 cases of acral melanoma. Twenty-one (43%) specimens contained tumor cells with clear cell changes in focal areas, whereas in 7 (14%) specimens clear cells were the major tumor constituting cells. The tumor thickness ranged from melanoma in situ to 14 mm. Immunohistochemistry demonstrated weak staining for S100 and HMB45 as well as strong positivity for Melan A and NK1C3. Recognition of clear cell features is important since differential diagnosis includes a variety of other clear cell malignancies, among them metastasis from renal cell carcinoma, clear cell sarcoma and hidradenocarcinoma.

  4. Communication Among Melanoma Family Members

    Science.gov (United States)

    Bowen, Deborah J; Albrecht, Terrance; Hay, Jennifer; Eggly, Susan; Harris-Wei, Julie; Meischke, Hendrika; Burke, Wylie

    2017-01-01

    Interventions to improve communication among family members may facilitate information flow about familial risk and preventive health behaviors. This is a secondary analysis of the effects of an interactive website intervention aimed at increasing communication frequency and agreement about health risk among melanoma families. Participants were family units, consisting of one family member with melanoma identified from a previous research study (the case) and an additional first degree relative and a parent of a child 0–17. Family triads were randomized to receive access to the website intervention or to serve as control families. Family communication frequency and agreement about melanoma prevention behaviors and beliefs were measured at baseline and again at one year post randomization. Intervention participants of all three types significantly increased the frequency of communication to their first degree relatives (Parents, siblings, children; range =14–18 percentage points; all pcommunication about cancer risk. PMID:28248624

  5. Genetic alterations and markers of melanoma

    Directory of Open Access Journals (Sweden)

    N. N. Mazurenko

    2014-01-01

    Full Text Available Melanoma remains the most deadly form of malignant skin disease with high risk of metastases. Metastatic melanoma is prognostic highly unfavorable and resistant to traditional chemotherapy and biologic treatment. There is a great progress in understanding of the molecular mechanisms underlying melanoma initiation and progression. The external (ultraviolet irradiation and internal (genetic factors are involved in melanoma genesis. 5–14 % of melanoma cases occur in familial context due to genetic predisposition risk factors. Among them rare germinal mutations in the cell cycle genes regulators CDKN2A and CDK4 and in the master gene of melanocyte homeostasis MITF, as well as single nucleotide polymorphisms of several low-penetrated genes, namely MC1R, have been identified. The main cell signaling pathways and oncogene driver mutations are involved in melanoma pathogenesis. RAS / RAF / MEK / ERK cascade is hyperactivated in 75 % of cutaneous melanoma cases. Activation of PI3K / AKT / mTOR signaling pathway is important for melanoma progression. Recent studies revealed that melanomas are genetically and phenotypically heterogeneous tumors. Spectrum of chromosomal alterations and activating mutations corresponding to tumor molecular portraits varies in melanomas of different location. Most of cutaneous melanomas contain BRAF (50 % or NRAS (20 % mutations, and NRAS mutations occur on chronically sun-exposed skin. Activating KIT mutations have been reported in approximately 20–30 % of certain subtypes of melanoma, including acral and mucosal, and melanoma that develop on photodamaged skin. Cutaneous metastatic melanoma derive from preexisting nevi in 25 % of cases, molecular mechanisms of nevi malignization are discussed. Deepsequencing approaches of melanoma samples of different melanoma types highlighted new melanoma driver genes, that are damaged due to tumorigenic effects of ultraviolet: PPP6C, RAC1, SNX31, TACC1 and STK19. The

  6. Familial skin cancer syndromes: Increased melanoma risk.

    Science.gov (United States)

    Ransohoff, Katherine J; Jaju, Prajakta D; Jaju, Prajaka D; Tang, Jean Y; Carbone, Michele; Leachman, Sancy; Sarin, Kavita Y

    2016-03-01

    Phenotypic traits, such as red hair and freckling, increase melanoma risk by 2- to 3-fold. In addition, approximately 10% of melanomas are caused by inherited germline mutations that increase melanoma risk from 4- to >1000-fold. This review highlights the key genes responsible for inherited melanoma, with an emphasis on when a patient should undergo genetic testing. Many genetic syndromes associated with increased melanoma risk are also associated with an increased risk of other cancers. Identification of these high-risk patients is essential for preventive behavior reinforcement, genetic counseling, and ensuring other required cancer screenings. Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  7. Melanoma: oncogenic drivers and the immune system.

    Science.gov (United States)

    Karachaliou, Niki; Pilotto, Sara; Teixidó, Cristina; Viteri, Santiago; González-Cao, María; Riso, Aldo; Morales-Espinosa, Daniela; Molina, Miguel Angel; Chaib, Imane; Santarpia, Mariacarmela; Richardet, Eduardo; Bria, Emilio; Rosell, Rafael

    2015-10-01

    Advances and in-depth understanding of the biology of melanoma over the past 30 years have contributed to a change in the consideration of melanoma as one of the most therapy-resistant malignancies. The finding that oncogenic BRAF mutations drive tumor growth in up to 50% of melanomas led to a molecular therapy revolution for unresectable and metastatic disease. Moving beyond BRAF, inactivation of immune regulatory checkpoints that limit T cell responses to melanoma has provided targets for cancer immunotherapy. In this review, we discuss the molecular biology of melanoma and we focus on the recent advances of molecularly targeted and immunotherapeutic approaches.

  8. Online learning management systems (LMS and sense of community: A pre-service practicum perspective

    Directory of Open Access Journals (Sweden)

    Glenn Rideout

    2008-05-01

    Full Text Available This paper examines the impact of the implementation of an online learning management system (LMS on pre-service teachers during their major pre-service practicum. The LMS enabled students to remain connected to peers, professors, and supervisors while new relationships were formed with in-school personnel such as mentor teachers, principals, and students. The quantitative data analysis revealed that pre-service teachers perceived a higher sense of community when it included pre-service teachers only than when it included teaching faculty and part-time practicum supervisors. The online LMS was identified as the best predictor of a sense of community among pre-service teachers, when compared to other variables, and not a significant predictor when community included part-time practicum supervisors. The paper concludes with an examination of the perspectives of provincial Ministries of Education and Teachers Federations in relation to the role and evaluation of educational technology initiatives. Résumé: Cet article examine l’impact de l’implantation d’une plateforme eLearning (LMS sur de futurs enseignants en stage. La plateforme a permis aux étudiants de rester en contact avec leurs pairs, leur professeurs et leurs superviseurs, alors que de nouvelles relations se formaient avec la collectivité de l’école les accueillant pour leur stage (mentor, directeur d’école et élèves. L’analyse des données quantitatives a révélé que les futurs enseignants percevaient un meilleur esprit communautaire quand seuls les futurs enseignants en faisaient partie par opposition à une communauté composée des futurs enseignants, des professeurs de leur programme et les superviseurs à temps partiel de leur stage. La plateforme LMS a été identifiée comme le meilleur prédicteur de l’esprit communautaire chez les futurs enseignants par comparaison avec d’autres variables, et un prédicteur non significatif quand la communauté incluait

  9. Choroidal melanoma in a dog.

    Science.gov (United States)

    Miwa, Yasutsugu; Matsunaga, Satoru; Kato, Kumiko; Ogawa, Hiroyuki; Nakayama, Hiroyuki; Tsujimoto, Saori; Sasaki, Nobuo

    2005-08-01

    A 7-year-old intact female golden Retriever was referred for evaluation of an intraorbital mass of the left eye. Based on ophthalmoscopy, ultrasonography and magnetic resonance imaging (MRI), the tentative diagnosis was made as an intraocular neoplasia, especially choroidal melanoma. The orbital exenteration of the affected eye was performed. The mass was histologically diagnosed as malignant choroidal melanoma. No signs of recurrence and metastasis were detected by thoracic radiographs, blood examinations and MR images, and the dog was clinically healthy for 23 months after operation.

  10. Oral mucosal melanoma: A case report

    Directory of Open Access Journals (Sweden)

    Ramlal Gantala

    2017-01-01

    Full Text Available Malignant melanoma is most deadly of all primary skin cancers. Over 90% of melanomas occur on the skin. Half of such melanomas occur in the oral cavity, followed by nasal cavity (44% and sinuses (8%. In the oral cavity, the most frequent sites of occurrence are hard palate and maxillary gingiva. Mucosal melanomas represent a diagnostic challenge than the more common cutaneous melanomas because oral melanomas demonstrate significant heterogeneity in morphological features, developmental process, and biological behaviour. This case report highlights an exophytic, lobulated oral malignant melanoma involving maxillary gingiva and is presented to reemphasize the fact that any pigmented lesion in the oral cavity should be examined with suspicion; proper investigation should be carried out to rule out any untoward experiences later.

  11. A Development of a Knowledge Management Model of Supervision of Practicum Students in Early Childhood Education, Faculty of Education, Mahasarakham University

    Directory of Open Access Journals (Sweden)

    Srikunyarphat Rangsriborwornkul

    2017-06-01

    Full Text Available The purpose of this study was to develop a model of knowledge management of supervision of practicum students in early childhood education. The target groups were 1 four supervisors in Early Childhood Education program, faculty of Education, Mahasarakham University and 2 thirty-three fifth-year practicum students in early childhood education practicing in professional experience at schools which located in Mahasarakham, Khonkaen, and Roi-Et provinces. The research tool was a survey form of supervision of practicum students. Content analysis was used. The research findings showed that 1 a development of the knowledge management model of supervision of practicum students in early childhood education contained 3 phases: phase I – studying need assessment, phase II – developing a model and phase III – conclusion and 2 data from the survey form of knowledge management of supervision categorized into two aspects, namely, appropriate practices and inappropriate practices.

  12. Exploring Reflective Teaching through Informed Journal Keeping and Blog Group Discussion in the Teaching Practicum

    Directory of Open Access Journals (Sweden)

    Edgar Alirio Insuasty

    2010-10-01

    Full Text Available This article reports the findings of a study which examined how student teachers could be empowered as more reflective practitioners through journal keeping and blog group discussions. It was carried out with six student teachers who developed their practicum over six months. Data were collected through journals, blogs, metaphors, conferences and a questionnaire. The results demonstrated that student teachers enriched their perceptions about what reflective teaching implied. Furthermore, journal keeping was approached as an informed process by virtue of which student-teachers could go beyond the descriptive documentation of what happened in their classes. Their journal entries also revealed reflective references, most of which were mainly focused on evaluating teaching, diagnosing and solving problems.

  13. The Virtual Clinical Practicum: an innovative telehealth model for clinical nursing education.

    Science.gov (United States)

    Grady, Janet L

    2011-01-01

    The Virtual Clinical Practicum (VCP) involves a clinical nursing education delivery strategy that uses video teleconferencing technology to address time, distance, and resource barriers. Technology-delivered education can augment the existing curriculum by increasing student access to clinical experts in specialty areas, thus supporting efficient use of faculty resources. This article describes the implementation of the VCP process and student perceptions of its effectiveness and usefulness. The VCP was shown to be a successful method of clinical nursing education, offering students exposure to clinical situations not available by other means. Opportunities for dialogue, critical reflection, and synthesis allowed students to experience the benefits of a traditional experience, enhanced through technology and tailored to the specific needs of the students. Respondents overwhelmingly recommended further use of the VCP to augment existing clinical nursing education methods.

  14. Evaluación de competencias en el PRACTICUM del Grado en Enfermería

    OpenAIRE

    Visiers Jiménez, Laura; Martín-Arribas, María Concepción

    2015-01-01

    El Espacio Europeo de Educación Superior ha supuesto un cambio de paradigma en la concepción de la educación y la evaluación en la universidad. Hace énfasis en la formación basada en competencias y en el alumno como motor y protagonista de su aprendizaje. En el Grado en Enfermería, el Practicum adquiere protagonismo en la formación del estudiante, al perfilarse cómo el escenario idóneo para la adquisición competencial global. La evaluación y autoevaluación por competencias requiere de la comb...

  15. Nursing students' perceptions of using smartphones in the community practicum: A qualitative study.

    Science.gov (United States)

    Beauregard, Philippe; Arnaert, Antonia; Ponzoni, Norma

    2017-06-01

    Smartphones have the potential to revolutionize the way in which nurses practice by facilitating access to evidence-based resources, however their integration in nursing practice remain variable. Millennials tend to be more comfortable with technology, yet find themselves limited in their ability to use smartphones within the context of clinical practice. Using a qualitative descriptive design, we explored nursing students' perceptions of using smartphones in the community practicum. Individual semi-structured interviews were conducted and verbatim transcripts were subjected to data analysis. The sample consisted of 8 undergraduate and graduate nursing students. Participants were recruited using a purposive sampling strategy. Students' narratives describe unclear expectations regarding the use of smartphones that force them to adopt individualized strategies to maintain their professional image and avoid negative consequences. A cultural shift will be required at the academic and organizational levels if we are to foster acceptance of smartphones in community practice going forward. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Action Research Topics and Questions in a Foreign Languages Teaching Practicum in Colombia

    Directory of Open Access Journals (Sweden)

    Maria McNulty Ferri

    2010-04-01

    Full Text Available Introduction: Preservice teachers identify topics and formulate research questions in action research under the guidance of advisors in the teaching practicum of an undergraduate foreign languages teaching program in Colombia. Objective: To examine preservice teachers' and advisors' beliefs about useful methodological strategies to identify the topics and formulate the research questions, and the roles they assumed. Method: In this case study, structured questionnaires and semi-structured interviews were used with the participants. Results: This study shows that journal writing, collaborative dialogue, exploring and expanding one's theoretical base, delimiting topics, and demonstrating work were useful strategies. Though preservice teachers took ownership of choosing topics and formulating questions, some shared roles led advisors to participate more actively in this process. Conclusions: The methodological process used to identify the topics and formulate the research questions is associated with a reflective professional development endeavour with individual and group reflection.

  17. Failure to Fail in a Final Pre-service Teaching Practicum

    Directory of Open Access Journals (Sweden)

    Patricia J. Danyluk

    2015-12-01

    Full Text Available This article presents a Canadian perspective on the issue of failure to fail in Bachelor of Education programs. The issue of failure to fail in Bachelor of Education programs is one that had not been explored in any great detail. What literature does exist focuses on the strain that a teacher experiences when s/he mentors a student teacher (Siebert, Clark, Kilbridge, & Peterson, 2006 and the wide variety of situations that can result in failure (Sudzina & Knowles, 1992. This study examines whether the issue of failure to fail in final pre-service practica exist and, if so, why? Twelve interviews were conducted at a mid-sized Canadian university in Ontario with university supervisors and associate teachers on the topic of teacher candidate failure during the final teaching practicum. All participants had experience with teacher candidates struggling during practicum. Faculty commented on their supervision of student teachers in Ontario, other provinces in Canada, and the United States. Results indicate that both university supervisors and associate teachers find the decision to fail a student teacher difficult, taking an emotional toll on both the supervisor and the student. University faculty report the decision to fail results in additional work for the faculty responsible; however, failure to fail an underperforming student teacher could diminish the reputation of professional programs. Associate teachers feel a sense of betrayal when their recommendations to fail an under-performing student are not followed by the university. These findings have implications for improving the quality of field experiences and support for students, associate teachers, and faculty in Bachelor of Education programs.

  18. Application of pedagogy reflective in statistical methods course and practicum statistical methods

    Science.gov (United States)

    Julie, Hongki

    2017-08-01

    Subject Elementary Statistics, Statistical Methods and Statistical Methods Practicum aimed to equip students of Mathematics Education about descriptive statistics and inferential statistics. The students' understanding about descriptive and inferential statistics were important for students on Mathematics Education Department, especially for those who took the final task associated with quantitative research. In quantitative research, students were required to be able to present and describe the quantitative data in an appropriate manner, to make conclusions from their quantitative data, and to create relationships between independent and dependent variables were defined in their research. In fact, when students made their final project associated with quantitative research, it was not been rare still met the students making mistakes in the steps of making conclusions and error in choosing the hypothetical testing process. As a result, they got incorrect conclusions. This is a very fatal mistake for those who did the quantitative research. There were some things gained from the implementation of reflective pedagogy on teaching learning process in Statistical Methods and Statistical Methods Practicum courses, namely: 1. Twenty two students passed in this course and and one student did not pass in this course. 2. The value of the most accomplished student was A that was achieved by 18 students. 3. According all students, their critical stance could be developed by them, and they could build a caring for each other through a learning process in this course. 4. All students agreed that through a learning process that they undergo in the course, they can build a caring for each other.

  19. On the role of a permeable groyne in beach morphodynamics during sea-breeze events in Yucatàn, Mexico

    NARCIS (Netherlands)

    Hofman, Anne; Roos, Pieter C.; Torres-Freyermuth, Alec

    2017-01-01

    The north coast of the Yucatàn peninsula in Mexico is vulnerable to strong sea breezes, which in turn causes high waves, driving high rates of erosion due to littoral transport. To find a solution for erosion problems caused by currently applied measurements, a permeable groyne was introduced,

  20. Cutavirus in Cutaneous Malignant Melanoma

    DEFF Research Database (Denmark)

    Mollerup, Sarah; Fridholm, Helena; Vinner, Lasse

    2017-01-01

    A novel human protoparvovirus related to human bufavirus and preliminarily named cutavirus has been discovered. We detected cutavirus in a sample of cutaneous malignant melanoma by using viral enrichment and high-throughput sequencing. The role of cutaviruses in cutaneous cancers remains...

  1. Prognostic stratification of ulcerated melanoma

    DEFF Research Database (Denmark)

    Bønnelykke-Behrndtz, Marie L; Schmidt, Henrik; Christensen, Ib J

    2014-01-01

    OBJECTIVES: For patients with melanoma, ulceration is an important prognostic marker and interestingly also a predictive marker for the response of adjuvant interferon. A consensual definition and accurate assessment of ulceration are therefore crucial for proper staging and clinical management. We...

  2. Stages of Intraocular (Uveal) Melanoma

    Science.gov (United States)

    ... or tans poorly. Blue or green or other light-colored eyes. Older age. Being white. Signs of intraocular melanoma include blurred vision ... to treat small tumors. This is also called light coagulation. ... are being tested in clinical trials. Information about clinical trials ...

  3. Prognostic Factors in Uveal Melanoma

    NARCIS (Netherlands)

    E. Kiliç (Emine)

    2006-01-01

    textabstractUveal melanoma is the most common intra-ocular tumour in the western world with an annual incidence of seven per million. Approximately 50% of the patients treated by enucleation dye eventually due to metastatic disease. Besides enucleation there are nowadays more conservative treatment

  4. Pediatric melanoma: incidence, treatment, and prognosis

    Directory of Open Access Journals (Sweden)

    Saiyed FK

    2017-04-01

    Full Text Available Faiez K Saiyed,1 Emma C Hamilton,1 Mary T Austin,1,2 1Department of Pediatric Surgery, McGovern Medical School, 2Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Abstract: The purpose of this review is to outline recent advancements in diagnosis, treatment, and prevention of pediatric melanoma. Despite the recent decline in incidence, it continues to be the deadliest form of skin cancer in children and adolescents. Pediatric melanoma presents differently from adult melanoma; thus, the traditional asymmetry, border irregularity, color variegation, diameter >6 mm, and evolution (ABCDE criteria have been modified to include features unique to pediatric melanoma (amelanotic, bleeding/bump, color uniformity, de novo/any diameter, evolution of mole. Surgical and medical management of pediatric melanoma continues to derive guidelines from adult melanoma treatment. However, more drug trials are being conducted to determine the specific impact of drug combinations on pediatric patients. Alongside medical and surgical treatment, prevention is a central component of battling the incidence, as ultraviolet (UV-related mutations play a central role in the vast majority of pediatric melanoma cases. Aggressive prevention measures targeting sun safety and tanning bed usage have shown positive sun-safety behavior trends, as well as the potential to decrease melanomas that manifest later in life. As research into the field of pediatric melanoma continues to expand, a prevention paradigm needs to continue on a community-wide level. Keywords: melanoma, pediatric, adolescent, childhood

  5. Guideline on the Management of Melanoma | Board | South African ...

    African Journals Online (AJOL)

    Validation. Melanoma management involves many medical specialties. Guidelines should therefore be developed through a multidisciplinary consensus. The Melanoma Advisory Board consists of a forum of dermatologists, oncologists, plastic surgeons and pathologists. Guideline sponsor. The meetings of the Melanoma ...

  6. Mucosal malignant melanoma - a clinical, oncological, pathological and genetic survey

    DEFF Research Database (Denmark)

    Mikkelsen, Lauge H; Larsen, Ann-Cathrine; von Buchwald, Christian

    2016-01-01

    Mucosal melanomas constitute 1.3% of all melanomas and they may develop in any mucosal membrane. Conjunctival melanomas (0.5/million/year) and melanomas in the sinonasal cavity (0.5/million/year) are the most common, followed by anorectal melanomas (0.4/million/year) and melanomas in the oral...... cavity (0.2/million/year). Anorectal melanoma occurs slightly more often in females, whereas oral melanoma has a male predilection. Mucosal melanoma most commonly develops in a patient's sixth or seventh decade of life, and no differences between races have been found except for sinonasal melanoma...... is the treatment of choice. The prognosis is poor, with the 5-year survival rate ranging from 0% (gastric melanoma) to 80% (conjunctival melanoma)....

  7. A Numerical Study of A Sea-breeze Front and Its Interaction With The Convective Boundary Layer Over Land During Cape

    Science.gov (United States)

    Hsu, W. R.; Wu, C. C.; Sun, W. Y.

    A sea-breeze front forms at the leading edge of the circulation induced by the con- vective boundary layer over land during daytime. Once the sea-breeze circulation is established, the front usually propagates onshore and sweeps through the convection cells inside the CBL over land near coastal area. The intensity of the front may change from time to time as it merges with those convection cells, while the front also modi- fies the basic characteristics of the CBL (such as surface fluxes, cloud thickness, etc). The interaction between the front and the CBL can be very complicated, and the sit- uation differs from cases to cases with different environmental conditions. With an extensive observation network, the 1991 Convection and Precipitation/Electrification Experiment (CaPE) have documented the phenomenon for several sea-breeze events in southern Florida, USA. In this study, we used the NTU/Purdue nonhydrostatic numerical model to simulate and investigate one of the sea-breeze events during CaPE. The numerical model is quite complete as it includes calculations for Coriolis force, land processes, clouds, the surface similarity equation and a prognostic equation for turbulence kinetic en- ergy in addition to a basic dynamic framework. A major advantage of the model is the use of a forward-backward integration scheme to treat high frequency and internal gravity waves explicitly. The numerical procedure is shown in one of authorsS earlier work to be quite accurate and also free from unstable computational modes. The re- sults showed that the model is capable of reproducing many interesting features of the phenomenon. These features include the CBL development over land, cloud pattern, frontal characteristics, etc. The turbulence and mixing properties of the CBL under the influence of the simulated sea-breeze circulation is discussed in the paper.

  8. Risk factors for second primary melanoma among Dutch patients with melanoma

    NARCIS (Netherlands)

    Schuurman, M.S.; Waal, A.C. de; Thijs, E.J.M.; Rossum, M.M. van; Kiemeney, L.A.L.M.; Aben, K.K.H.

    2017-01-01

    BACKGROUND: Patients with melanoma are at increased risk of developing subsequent primary melanomas. Knowledge about risk factors for these subsequent primaries is scarce. More evidence may help clinicians in tailoring surveillance schedules by selecting patients who could benefit from intensified

  9. An assessment of students' confidence in performing psychiatric mental health nursing skills: the impact of the clinical practicum experience.

    Science.gov (United States)

    Fiedler, Ruth Anne; Breitenstein, Susie; Delaney, Kathleen

    2012-01-01

    In 2008, the American Psychiatric Nurses Association and the International Society for Psychiatric Nursing jointed developed Psychiatric Mental Health Nursing competencies for BSN students. In the newly created accelerated track of the BSN program, students spend less time than traditional students in psychiatric mental health (PMH) clinical practica. The primary objective was to discover how the PMH practicum experience influences BSN students' perceptions of their confidence in performing PMH clinical skills. An evaluation design was used in this study. There was significant improvement in students' confidence performing PMH clinical competencies after completing the PMH nursing practicum. The current structure of clinical provides students with experiences that promote their confidence. Students self-assessment about learning needs and skill level should be assessed preclinically to allow for practice to gain confidence.

  10. "I live in a bubble": Speech-language therapy and audiology students' expectations and experiences of a rural community work practicum.

    Science.gov (United States)

    Watermeyer, J; Barratt, J

    2013-01-01

    Locally and internationally, there have been renewed calls for equitable access to healthcare services. Simultaneously, caseloads have become more challenging and contexts more complex, which may be overwhelming to new graduates. The South African context offers a particularly interesting example of these challenges. Educators need to use innovative ways to ensure that curricula adequately prepare students for rural community work, while developing a sense of leadership that links clinical practice to theory, policy, ethics and social responsibility. Rural practica offer opportunities for sensitizing and equipping students for working in underserviced communities and a number of international studies have documented their potential usefulness. There is limited research, however, that examines how exposure to rural community work may shape students' responses to the realities of working in such contexts. This study aimed to explore the processes underlying a group of South African speech-language therapy and audiology students' appreciation and understanding of the realities of work in a rural community after a rural practicum. A four-day practicum took place in a rural community in South Africa. The practicum incorporated basic audiological tasks and structured observations. Twenty-five third-year students completed anonymous pre- and post-practicum open-ended questionnaires. The questionnaires explored their expectations and perceptions of the practicum, perceived challenges and benefits of working in rural community areas, and considerations that might need to be taken into account. The questionnaires were analysed and compared using thematic analysis principles. Results revealed a distinction between students' emotional and personal expectations of, and responses to, the practicum compared to their clinical expectations and responses. Before the practicum, students indicated a number of anxieties such as not feeling emotionally prepared or feeling anxious about

  11. Metastatic melanoma masquerading as a furuncle

    Directory of Open Access Journals (Sweden)

    Imran Aslam

    2017-10-01

    Full Text Available Melanoma metastasizes to the skin in about 10-17% of patients. Although there are reports of metastatic melanoma masquerading as panniculitis and erysipelas, it is very uncommon for it to present as an inflammatory skin lesion. When malignant melanoma cells invade the superficial dermal lymphatic vessels it can result in erythema, edema and induration of the overlying skin. This presentation can be problematic for clinicians if they do not suspect melanoma and choose not to biopsy the lesion. We report a case of an elderly man with a history of invasive melanoma who presented with a furuncle-like lesion that was found to be in-transit metastatic melanoma.

  12. Molecular insights into melanoma brain metastases.

    Science.gov (United States)

    Westphal, Dana; Glitza Oliva, Isabella C; Niessner, Heike

    2017-06-01

    Substantial proportions of patients with metastatic melanoma develop brain metastases during the course of their disease, often resulting in significant morbidity and death. Despite recent advances with BRAF/MEK and immune-checkpoint inhibitors in the treatment of patients who have melanoma with extracerebral metastases, patients who have melanoma brain metastases still have poor overall survival, highlighting the need for further therapy options. A deeper understanding of the molecular pathways involved in the development of melanoma brain metastases is required to develop more brain-specific therapies. Here, the authors summarize the currently known preclinical data and describe steps involved in the development of melanoma brain metastases. Only by knowing the molecular background is it possible to design new therapeutic agents that can be used to improve the outcome of patients with melanoma brain metastases. Cancer 2017;123:2163-75. © 2017 American Cancer Society. © 2017 American Cancer Society.

  13. Melanoma-specific marker expression in skin biopsy tissues as a tool to facilitate melanoma diagnosis.

    Science.gov (United States)

    Alexandrescu, Doru T; Kauffman, C Lisa; Jatkoe, Timothy A; Hartmann, Dan P; Vener, Tatiana; Wang, Haiying; Derecho, Carlo; Rajpurohit, Yashoda; Wang, Yixin; Palma, John F

    2010-07-01

    Diagnosis of cutaneous melanoma requires accurate differentiation of true malignant tumors from highly atypical lesions, which lack the capacity to develop uncontrolled proliferation and to metastasize. We used melanoma markers from previous work to differentiate benign and atypical lesions from melanoma using paraffin-embedded tissue. This critical step in diagnosis generates the most uncertainty and discrepancy between dermatopathologists. A total of 193 biopsy tissues were selected: 47 melanomas, 48 benign nevi, and 98 atypical/suspicious, including 48 atypical nevi and 50 melanomas as later assigned by expert dermatopathologists. Performance for SILV, GDF15, and L1CAM normalized to TYR in unequivocal melanoma versus benign nevi resulted in an area under the curve (AUC) of 0.94, 0.67, and 0.5, respectively. SILV also differentiated atypical cases classified as melanoma from atypical nevi with an AUC=0.74. Furthermore, SILV showed a significant difference between suspicious melanoma and each suspicious atypia group: melanoma versus severe atypia and melanoma versus moderate atypia had P-values of 0.0077 and 0.0009, respectively. SILV showed clear discrimination between melanoma and benign unequivocal cases as well as between different atypia subgroups in the group of suspicious samples. The role and potential utility of this molecular assay as an adjunct to the morphological diagnosis of melanoma are discussed.

  14. Melanoma of unknown origin: a case series.

    LENUS (Irish Health Repository)

    Kelly, J

    2010-12-01

    The natural history of metastatic melanoma involving lymph nodes, in the absence of a known primary site (cutaneous, ocular or mucosal) has, to date, been poorly defined; and the optimal management of this rare subtype of disease is therefore unclear. Melanomas of unknown primary site (MUP) are estimated to comprise between 3.7 and 6% of all melanomas (Anbari et al. in Cancer 79:1861-1821, 1997).

  15. Melanoma epidemiology, prognosis and trends in Latvia.

    Science.gov (United States)

    Azarjana, K; Ozola, A; Ruklisa, D; Cema, I; Rivosh, A; Azaryan, A; Pjanova, D

    2013-11-01

    Melanoma incidence and mortality rates are increasing worldwide within the white population. Clinical and histological factors have been usually used for the prognosis and assessment of the risk for melanoma. The aim of the study was to describe the clinical and histopathological features of the cutaneous melanoma (CM) in the Latvian population, to test the association between melanoma features and patient survival, and to assess the time trends for melanoma incidence. We undertook a descriptive, retrospective analysis of archive data of 984 melanoma patients treated at the largest oncological hospital of Latvia, Riga East University Hospital Latvian Oncology Centre (LOC), between 1998 and 2008. Cox proportional hazards model was used to analyse patient survival and autoregressive models were applied to detect trends in melanoma incidence over time for various categories of melanoma. The study showed a significant ascending trend in melanoma incidence in Latvia during the time period from 1998 to 2008 (ß = 1.83, 95% CI = 1.15-2.91, P = 0.011). Nodular melanoma was the most common tumour subtype with a frequency of 39.2%. Ulceration was present in 45.2% of melanomas. The mean Breslow thickness was 6.0 mm (6.8 mm) and no significant decline in median Breslow thickness was observed during the study period (P = 0.609). A better overall prognosis was detected for females in comparison with males (HR = 1.49; 95% CI = 1.22-1.81; P Latvia with the majority of melanomas diagnosed at late stages with poor prognosis for survival. © 2012 The Authors Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology.

  16. Giant hanging melanoma of the eyelid skin

    Directory of Open Access Journals (Sweden)

    Pai Radha

    2008-01-01

    Full Text Available Cutaneous melanoma of the eyelid is a rare entity. We present a 53-year-old male who had a nevus on the left upper eyelid skin since childhood, which transformed into a huge ulcerated hanging mass in the same region. Excision of the mass was done and histopathology confirmed the diagnosis of nodular malignant melanoma. A small preauricular lymph node showed metastatic melanoma on fine needle aspiration cytology.

  17. Reorganization of Practicum in Initial Teacher Education: A Search for Challenges in Implementation by Ex-Ante Evaluation

    Directory of Open Access Journals (Sweden)

    Laila Niklasson

    2015-10-01

    Full Text Available The background of the study is a perceived need of increasing quality in practice during Initial Teacher Education (ITE in Sweden. In order to achieve higher quality, the government encourages reorganization towards a limited number of practice schools, competence development for supervisors and research focusing on the selected practice schools.  The aim of this study is to present and critically discuss prerequisites for implementation of the reform. The paper focuses on how a preliminary logic model and a SWOT analysis can show challenges encountered during the implementation of the reorganization. By using the logic model and the SWOT analysis an ex-ante evaluation was carried out in two steps. The results disclosed that the motivation behind reorganization, improving the quality of practicum, might meet some challenges. Indicators of higher quality being attained are not provided; the local organization is expected to construct such indicators during the process. In contrast to the challenges the results showed that the implementation was supported by earlier good relations and a common idea of developing practicum in ITE. The implication for implementation is a need to have a dialogue about indicators for quality among different stakeholders in ITE. Without such a dialogue it can be disputed whether the change in practicum was successful.

  18. Timely Healthcare Checkup Catches Melanoma Early

    Science.gov (United States)

    ... Skin Cancer" Articles Skin Cancer Can Strike Anyone / Skin Cancer: Biology, Risk Factors & Treatment / Timely Healthcare Checkup Catches Melanoma Early / NIH Research to Results / Skin and Sun – ...

  19. Genomic characterisation of acral melanoma cell lines.

    Science.gov (United States)

    Furney, Simon J; Turajlic, Samra; Fenwick, Kerry; Lambros, Maryou B; MacKay, Alan; Ricken, Gerda; Mitsopoulos, Costas; Kozarewa, Iwanka; Hakas, Jarle; Zvelebil, Marketa; Lord, Christopher J; Ashworth, Alan; Reis-Filho, Jorge S; Herlyn, Meenhard; Murata, Hiroshi; Marais, Richard

    2012-07-01

    Acral melanoma is a rare melanoma subtype with distinct epidemiological, clinical and genetic features. To determine if acral melanoma cell lines are representative of this melanoma subtype, six lines were analysed by whole-exome sequencing and array comparative genomic hybridisation. We demonstrate that the cell lines display a mutation rate that is comparable to that of published primary and metastatic acral melanomas and observe a mutational signature suggestive of UV-induced mutagenesis in two of the cell lines. Mutations were identified in oncogenes and tumour suppressors previously linked to melanoma including BRAF, NRAS, KIT, PTEN and TP53, in cancer genes not previously linked to melanoma and in genes linked to DNA repair such as BRCA1 and BRCA2. Our findings provide strong circumstantial evidence to suggest that acral melanoma cell lines and acral tumours share genetic features in common and that these cells are therefore valuable tools to investigate the biology of this aggressive melanoma subtype. Data are available at: http://rock.icr.ac.uk/collaborations/Furney_et_al_2012/. © 2012 John Wiley & Sons A/S.

  20. Melanoma of the skin in the Danish Cancer Registry and the Danish Melanoma Database: A Validation Study.

    Science.gov (United States)

    Pedersen, Sidsel Arnspang; Schmidt, Sigrun Alba Johannesdottir; Klausen, Siri; Pottegård, Anton; Friis, Søren; Hölmich, Lisbet Rosenkrantz; Gaist, David

    2018-01-15

    The nationwide Danish Cancer Registry and the Danish Melanoma Database both record data on melanoma for purposes of monitoring, quality assurance and research. However, the data quality of the Cancer Registry and the Melanoma Database has not been formally evaluated. We estimated the positive predictive value (PPV) of melanoma diagnosis for random samples of 200 patients from the Cancer Registry (n=200) and the Melanoma Database (n=200) during 2004-2014, using the Danish Pathology Registry as 'gold-standard' reference. We further validated tumor characteristics in the Cancer Registry and the Melanoma Database. Additionally, we estimated the PPV of in situ melanoma diagnoses in the Melanoma Database, and the sensitivity of melanoma diagnoses in 2004-2014. The PPVs of melanoma in the Cancer Registry and the Melanoma Database were 97% (95% CI, 94-99) and 100%. The sensitivity was 90% in the Cancer Registry and 77% in the Melanoma Database. The PPV of in situ melanomas in the Melanoma Database was 97% and the sensitivity was 56%. In the Melanoma Database, we observed PPVs of ulceration of 75% and Breslow thickness of 96%. The PPV of histologic subtypes varied between 87%-100% in the Cancer Registry and 93%-100% in the Melanoma Database. The PPVs for anatomical localization were 83%-95.0% in the Cancer Registry and 93%-100% in the Melanoma Database. The data quality in both the Cancer Registry and the Melanoma Database are high, supporting their use in epidemiologic studies.

  1. UVB: suscetibilidade no melanoma maligno

    OpenAIRE

    Nasser,Nilton

    2010-01-01

    FUNDAMENTOS: Está bem definido que a radiação ultravioleta provoca depleção imunológica na pele, permitindo o desenvolvimento de tumores cutâneos malignos. A maioria dos pacientes de cânceres da pele não melanomas são considerados UVB-suscetíveis. OBJETIVOS: Estudar a UVB-suscetibilidade nos pacientes com melanoma maligno e se este é um fator de risco para o desenvolvimento desse câncer. MÉTODOS: Foram selecionados 88 voluntários divididos em dois grupos: grupo-controle saudável (n=61) e grup...

  2. [Acute dyspnea in malignant melanoma].

    Science.gov (United States)

    Franzen, A M; Günzel, T

    2011-09-01

    Metastases to the larynx are rare. The current article presents the case of a 75-year-old patient with a history of shortness of breath due to a supraglottic exophytic lesion that was identified as a metastasis of a cutaneous melanoma treated 2.5 years previously. As a result of our medline analysis we found approximately 30 cases of metastatic melanoma to the larynx published to date. Primary tumors are always cutaneous in origin and spread over the whole integument of trunk and extremities. The time interval between diagnosis of the primary and the laryngeal metastasis is often several years. In most reports a supraglottic exophytic, red coloured lesion is described. Diagnosis can only be proven by histological examination. Laryngeal metastasis is usually an indication of tumor dissemination and always has a fatal prognosis.

  3. Neutron capture therapy for melanoma

    International Nuclear Information System (INIS)

    Coderre, J.A.; Glass, J.D.; Micca, P.; Fairchild, R.G.

    1988-01-01

    The development of boron-containing compounds which localize selectively in tumor may require a tumor-by-tumor type of approach that exploits any metabolic pathways unique to the particular type of tumor. Melanin-producing melanomas actively transport and metabolize aromatic amino acids for use as precursors in the synthesis of the pigment melanin. It has been shown that the boron-containing amino acid analog p-borono-phenylalanine (BPA) is selectively accumulated in melanoma tissue, producing boron concentrations in tumor that are within the range estimated to be necessary for successful boron neutron capture therapy (BNCT). We report here the results of therapy experiments carried out at the Brookhaven Medical Research Reactor (BMRR). 21 refs., 5 figs., 3 tabs

  4. BRAF mutations in conjunctival melanoma

    DEFF Research Database (Denmark)

    Larsen, Ann-Cathrine; Dahl, Christina; Dahmcke, Christina M.

    2016-01-01

    with atypia. BRAF mutations were identified in 39 of 111 (35%) cases. The rate ratio of BRAF-mutated versus BRAF-wild-type melanoma did not change over time. BRAF mutations were associated with T1 stage (p = 0.007), young age (p = 0.001), male gender (p = 0.02), sun-exposed location (p = 0.01), mixed....../non-pigmented tumour colour (p = 0.02) and nevus origin (p = 0.005), but did not associate with prognosis. BRAF status in conjunctival melanoma and paired premalignant lesions corresponded in 19 of 20 cases. Immunohistochemistry detected BRAF V600E mutations with a sensitivity of 0.94 and a specificity of 1...

  5. Neutron capture therapy for melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Coderre, J.A.; Glass, J.D.; Micca, P.; Fairchild, R.G.

    1988-01-01

    The development of boron-containing compounds which localize selectively in tumor may require a tumor-by-tumor type of approach that exploits any metabolic pathways unique to the particular type of tumor. Melanin-producing melanomas actively transport and metabolize aromatic amino acids for use as precursors in the synthesis of the pigment melanin. It has been shown that the boron-containing amino acid analog p-borono-phenylalanine (BPA) is selectively accumulated in melanoma tissue, producing boron concentrations in tumor that are within the range estimated to be necessary for successful boron neutron capture therapy (BNCT). We report here the results of therapy experiments carried out at the Brookhaven Medical Research Reactor (BMRR). 21 refs., 5 figs., 3 tabs.

  6. Thigmotropism of Malignant Melanoma Cells

    OpenAIRE

    Quatresooz, Pascale; Pi?rard-Franchimont, Claudine; No?l, Fanchon; Pi?rard, G?rald E.

    2011-01-01

    During malignant melanoma (MM) progression including incipient metastasis, neoplastic cells follow some specific migration paths inside the skin. In particular, they progress along the dermoepidermal basement membrane, the hair follicles, the sweat gland apparatus, nerves, and the near perivascular space. These features evoke the thigmotropism phenomenon defined as a contact-sensing growth of cells. This process is likely connected to modulation in cell tensegrity (control of the cell shape)....

  7. Dermoscopic evaluation of nodular melanoma.

    Science.gov (United States)

    Menzies, Scott W; Moloney, Fergal J; Byth, Karen; Avramidis, Michelle; Argenziano, Giuseppe; Zalaudek, Iris; Braun, Ralph P; Malvehy, Josep; Puig, Susana; Rabinovitz, Harold S; Oliviero, Margaret; Cabo, Horacio; Bono, Riccardo; Pizzichetta, Maria A; Claeson, Magdalena; Gaffney, Daniel C; Soyer, H Peter; Stanganelli, Ignazio; Scolyer, Richard A; Guitera, Pascale; Kelly, John; McCurdy, Olivia; Llambrich, Alex; Marghoob, Ashfaq A; Zaballos, Pedro; Kirchesch, Herbert M; Piccolo, Domenico; Bowling, Jonathan; Thomas, Luc; Terstappen, Karin; Tanaka, Masaru; Pellacani, Giovanni; Pagnanelli, Gianluca; Ghigliotti, Giovanni; Ortega, Blanca Carlos; Crafter, Greg; Ortiz, Ana María Perusquía; Tromme, Isabelle; Karaarslan, Isil Kilinc; Ozdemir, Fezal; Tam, Anthony; Landi, Christian; Norton, Peter; Kaçar, Nida; Rudnicka, Lidia; Slowinska, Monika; Simionescu, Olga; Di Stefani, Alessandro; Coates, Elliot; Kreusch, Juergen

    2013-06-01

    Nodular melanoma (NM) is a rapidly progressing potentially lethal skin tumor for which early diagnosis is critical. To determine the dermoscopy features of NM. Eighty-three cases of NM, 134 of invasive non-NM, 115 of nodular benign melanocytic tumors, and 135 of nodular nonmelanocytic tumors were scored for dermoscopy features using modified and previously described methods. Lesions were separated into amelanotic/hypomelanotic or pigmented to assess outcomes. Predominantly hospital-based clinics from 5 continents. Sensitivity, specificity, and odds ratios for features/models for the diagnosis of melanoma. Nodular melanoma occurred more frequently as amelanotic/hypomelanotic (37.3%) than did invasive non-NM (7.5%). Pigmented NM had a more frequent (compared with invasive non-NM; in descending order of odds ratio) symmetrical pigmentation pattern (5.8% vs 0.8%), large-diameter vessels, areas of homogeneous blue pigmentation, symmetrical shape, predominant peripheral vessels, blue-white veil, pink color, black color, and milky red/pink areas. Pigmented NM less frequently displayed an atypical broadened network, pigment network or pseudonetwork, multiple blue-gray dots, scarlike depigmentation, irregularly distributed and sized brown dots and globules, tan color, irregularly shaped depigmentation, and irregularly distributed and sized dots and globules of any color. The most important positive correlating features of pigmented NM vs nodular nonmelanoma were peripheral black dots/globules, multiple brown dots, irregular black dots/globules, blue-white veil, homogeneous blue pigmentation, 5 to 6 colors, and black color. A model to classify a lesion as melanocytic gave a high sensitivity (>98.0%) for both nodular pigmented and nonnodular pigmented melanoma but a lower sensitivity for amelanotic/hypomelanotic NM (84%). A method for diagnosing amelanotic/hypomelanotic malignant lesions (including basal cell carcinoma) gave a 93% sensitivity and 70% specificity for NM. When

  8. UVB: suscetibilidade no melanoma maligno UVB: susceptibility in malignant melanoma

    Directory of Open Access Journals (Sweden)

    Nilton Nasser

    2010-12-01

    Full Text Available FUNDAMENTOS: Está bem definido que a radiação ultravioleta provoca depleção imunológica na pele, permitindo o desenvolvimento de tumores cutâneos malignos. A maioria dos pacientes de cânceres da pele não melanomas são considerados UVB-suscetíveis. OBJETIVOS: Estudar a UVB-suscetibilidade nos pacientes com melanoma maligno e se este é um fator de risco para o desenvolvimento desse câncer. MÉTODOS: Foram selecionados 88 voluntários divididos em dois grupos: grupo-controle saudável (n=61 e grupo de portadores de melanoma (n=27, todos identificados de acordo com os critérios: tipo histológico, nível de invasão, fotótipos de pele, sexo e idade. A suscetibilidade à radiação ultravioleta B (UVB foi medida pela reação de hipersensibilidade ao contato com o difenciprone nos voluntários sensibilizados em áreas previamente irradiadas. RESULTADOS: A suscetibilidade à radiação UVB foi de 81,5% nos pacientes com melanoma maligno e de 31,2% no grupo-controle. O risco de um indivíduo desenvolver o melanoma maligno foi 9,7 vezes maior do que nos indivíduos UVB-resistentes. CONCLUSÕES: A UVB-suscetibilidade pode ser considerada um fator de risco importante para o desenvolvimento do melanoma maligno.BACKGROUND: It is well established that UV radiation provokes an immunological depletion in the skin, enabling the development of malignant cutaneous tumors. Most nonmelanoma skin cancer patients are considered to be UVB-susceptible. OBJECTIVE: To study the behavior of UVB- susceptibility in malignant melanoma (MM patients and whether this is a risk factor to the development of MM. METHODS: Eighty-eight volunteers were selected and divided into two groups: healthy control group (n = 61 and MM group (n = 27, which were identified according to the following clinical criteria: histopathological type, level of invasion, skin phototype, sex and age. Susceptibility to ultraviolet B (UVB radiation was measured by the onset of a contact

  9. Spontaneous Splenic Rupture in Melanoma

    Directory of Open Access Journals (Sweden)

    Hadi Mirfazaelian

    2014-01-01

    Full Text Available Spontaneous rupture of spleen due to malignant melanoma is a rare situation, with only a few case reports in the literature. This study reports a previously healthy, 30-year-old man who came with chief complaint of acute abdominal pain to emergency room. On physical examination, abdominal tenderness and guarding were detected to be coincident with hypotension. Ultrasonography revealed mild splenomegaly with moderate free fluid in abdominopelvic cavity. Considering acute abdominal pain and hemodynamic instability, he underwent splenectomy with splenic rupture as the source of bleeding. Histologic examination showed diffuse infiltration by tumor. Immunohistochemical study (positive for S100, HMB45, and vimentin and negative for CK, CD10, CK20, CK7, CD30, LCA, EMA, and chromogranin confirmed metastatic malignant melanoma. On further questioning, there was a past history of a nasal dark skin lesion which was removed two years ago with no pathologic examination. Spontaneous (nontraumatic rupture of spleen is an uncommon situation and it happens very rarely due to neoplastic metastasis. Metastasis of malignant melanoma is one of the rare causes of the spontaneous rupture of spleen.

  10. The influence of sea- and land-breeze circulations on the diurnal variability in precipitation over a tropical island

    Directory of Open Access Journals (Sweden)

    L. Zhu

    2017-11-01

    Full Text Available This study examines the diurnal variation in precipitation over Hainan Island in the South China Sea using gauge observations from 1951 to 2012 and Climate Prediction Center MORPHing technique (CMORPH satellite estimates from 2006 to 2015, as well as numerical simulations. The simulations are the first to use climatological mean initial and lateral boundary conditions to study the dynamic and thermodynamic processes (and the impacts of land–sea breeze circulations that control the rainfall distribution and climatology. Precipitation is most significant from April to October and exhibits a strong diurnal cycle resulting from land–sea breeze circulations. More than 60 % of the total annual precipitation over the island is attributable to the diurnal cycle with a significant monthly variability. The CMORPH and gauge datasets agree well, except that the CMORPH data underestimate precipitation and have a 1 h peak delay. The diurnal cycle of the rainfall and the related land–sea breeze circulations during May and June were well captured by convection-permitting numerical simulations with the Weather Research and Forecasting (WRF model, which were initiated from a 10-year average ERA-Interim reanalysis. The simulations have a slight overestimation of rainfall amounts and a 1 h delay in peak rainfall time. The diurnal cycle of precipitation is driven by the occurrence of moist convection around noontime owing to low-level convergence associated with the sea-breeze circulations. The precipitation intensifies rapidly thereafter and peaks in the afternoon with the collisions of sea-breeze fronts from different sides of the island. Cold pools of the convective storms contribute to the inland propagation of the sea breeze. Generally, precipitation dissipates quickly in the evening due to the cooling and stabilization of the lower troposphere and decrease of boundary layer moisture. Interestingly, the rather high island orography is not a

  11. Do melanoma patients with melanoma of unknown primary have better survival than patients with melanoma of known primary?

    DEFF Research Database (Denmark)

    Rødgaard, Jes Christian; Kjerkegaard, Ulrik; Sørensen, Jens Ahm

    2018-01-01

    Background: Several studies have compared the survival rate of melanoma of unknown primary (MUP) patients with patients with a known primary melanoma (MKP). Some studies found improved survival in MUP patients, whereas others found similar or poorer outcomes. The aim of this study was to evaluate...

  12. Is the prognosis and course of acral melanoma related to site-specific clinicopathological features?

    NARCIS (Netherlands)

    Paolino, G.; Bekkenk, M. W.; Didona, D.; Eibenschutz, L.; Richetta, A. G.; Cantisani, C.; Viti, G.; Carbone, A.; Buccini, P.; de Simone, P.; Ferrari, A.; Scali, E.; Calvieri, S.; Silipo, V.; Cigna, E.; Viti, G. P.; Bottoni, U.

    2016-01-01

    Acral melanoma is an uncommon type of melanoma in Caucasian patients. However, acral melanoma is the most common type of melanoma in African and Asian patients. Comparison analyses between hand-acral melanoma and foot-acral melanoma have been rarely reported in the literature. Acral melanoma is an

  13. Nodular melanoma: a distinct clinical entity and the largest contributor to melanoma deaths in Victoria, Australia.

    Science.gov (United States)

    Mar, Victoria; Roberts, Hugh; Wolfe, Rory; English, Dallas R; Kelly, John W

    2013-04-01

    There is a growing body of evidence that nodular melanoma (NM), because of its association with increased growth rate and thickness at diagnosis, accounts for a substantial proportion of melanoma deaths. We sought to assess the contribution of NM to melanoma deaths in comparison with other tumor subtypes. Four cohorts were established comprising 5775 cases of invasive primary cutaneous melanoma reported to the Victorian Cancer Registry during 1989, 1994, 1999, and 2004. Original pathology reports were reviewed. Age-standardized melanoma incidence rates were compared from 1989 to 2004 with annual percentage change using Poisson regression. The incidence of thick tumors (>4 mm) increased by 3.8% (95% confidence interval 1.4 to 6.2) and 2.5% (95% confidence interval -0.5 to 5.5) per year for male and female patients, respectively. The median thickness of NM at diagnosis was 2.6 mm compared with 0.6 mm for superficial spreading melanoma. A third of patients who died from melanoma during the follow-up period had thick tumors (>4 mm), most of which were nodular subtype (61%). NM accounted for 14% of invasive melanomas, but was responsible for 43% of melanoma deaths in a total of 57,461 person-years of follow-up. By comparison, superficial spreading melanoma contributed 56% of invasive melanoma but only 30% of deaths. Pathology review was limited to reports only. Mortality information relied mostly on death certificate information. The incidence of thick melanomas continues to increase. Nodular melanoma is clinically distinct and the predominant contributor to melanoma-related deaths, representing a public health challenge in reducing skin cancer mortality. Copyright © 2012 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  14. Nodular melanoma is less likely than superficial spreading melanoma to be histologically associated with a naevus.

    Science.gov (United States)

    Pan, Yan; Adler, Nikki R; Wolfe, Rory; McLean, Catriona A; Kelly, John W

    2017-10-16

    To determine the frequency of naevus-associated melanoma among superficial spreading and nodular subtypes; and to investigate associations between naevus-associated melanoma and other clinico-pathological characteristics. Cross-sectional study of all patients with nodular and superficial spreading melanomas diagnosed between 1994 and 2015 at the Victorian Melanoma Service, Melbourne. Clinical and pathological characteristics of naevus-associated and de novo melanomas were assessed in univariable and multivariable logistic regression analyses. Of 3678 primary melanomas, 1360 (37.0%) were histologically associated with a naevus and 2318 (63.0%) were de novo melanomas; 71 of 621 nodular (11.4%) and 1289 of 3057 superficial spreading melanomas (42.2%) were histologically associated with a naevus. In multivariable analyses, the odds of being associated with a naevus were higher for melanomas located on the trunk (v head and neck: adjusted odds ratio [OR], 2.27; 95% CI, 1.73-2.96; P melanomas (adjusted OR, 0.68; 95% CI, 0.48-0.97; P = 0.035), and older age (patients 70 years or older v patients under 30 at diagnosis: adjusted OR, 0.28; 95% CI, 0.20-0.40; P melanomas as for nodular melanomas (adjusted OR, 3.05; 95% CI, 2.24-4.17; P Melanomas are most likely to arise in the absence of a pre-existing naevus, particularly nodular melanomas. Public health campaigns should therefore emphasise the detection of suspicious de novo lesions, as well as of changing lesions.

  15. Isolated Pancreatic Metastasis from Malignant Melanoma: Is ...

    African Journals Online (AJOL)

    Isolated pancreatic metastasis from malignant melanoma (IPMMM) is rare because most melanoma patients already have a widespread disease at diagnosis. No adjuvant systemic treatment is known to be effi cient in this setting. Experience with pancreatic resection for IPMMM is limited and controversial. We report here ...

  16. Primary malignant melanoma of the nasal cavity.

    Science.gov (United States)

    Uysal, Ismail Önder; Misir, Mustafa; Polat, Kerem; Altuntaş, Emine Elif; Atalar, Mehmet Haydar; Tuncer, Ersin; Müderris, Suphi

    2012-01-01

    Primary malignant melanoma of the nose and paranasal sinus mucosa is a rare disease and seen in less than 1% among all melanomas. Malignant melanomas have 2 origins: cutaneous and mucosal. The mucosal form has a worse prognosis because of its aggressiveness compared with that of the cutaneous form. Mucosal melanomas often occur at a rate of 2% to 3% among all melanomas and are typically found in the nasal cavity and paranasal sinuses. Generally, it is more common in males and in those older than 50 years. In this study, 4 patients were observed at the Cumhuriyet University Faculty of Medicine; 2 of them were a 64-year-old man and an 82-year-old woman who had a malignant melanoma originating from the nasal septal mucosa, 1 patient was a 72-year-old woman whose malignant melanoma originated from the inferior turbinate, and 1 patient was a 77-year-old woman with a sinonasally located melanoma. The conditions of these patients were discussed under the light of literature instructions.

  17. PRIMARY MALIGNANT MELANOMA OF ARYEPIGLOTTIC FOLD

    African Journals Online (AJOL)

    2015-12-01

    Dec 1, 2015 ... ing including positron emission tomography (PET) scan failed to reveal a primary source of malignant melanoma. So, the patient was diagnosed as primary malignant melanoma of aryepiglottic mucosa. Figure 1 Photomicrograph showing origin of melano- ma (H&E, 100x). Figure 2 Photomicrograph ...

  18. Malignant melanoma at a scientific laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Shy, C.M.; Checkoway, H.; Marshall, E.G.

    1985-11-15

    The general consensus of the seven reviewers is that occupational exposures at Lawrence Livermore National Laboratory have not been established as a causal factor for the observed excess of malignant melanoma. Several observations support the impression that some or all of the observed melanoma excess may be attributable to intense surveillance and enhanced detection of early stage melanoma lesions. Since the incidence of melanomas among Laboratory employees has not diminished, an early harvesting effect is unlikely. This suggests the distinct possibility that localized, in situ melanomas that would normally not be detected are being reported, and that in the absence of this enhanced detection, many of these early stage lesions would show little or no clinical progression. This phenomenon would explain the continued high incidence of melanomas in the absence of a physical or chemical inciting cause. A key point in this reasoning is the issue of the rate of growth of early stage melanomas, and this point remains a key question for study. Even if the observed excess cannot be explained by detection bias, the reviewers agree that the Austin and Reynolds' study does not make a convincing case for occupational factors being a cause of the high melanoma incidence. 6 refs.

  19. Histopathological study of malignant melanoma in highlanders ...

    African Journals Online (AJOL)

    Histopathological study of malignant melanoma in highlanders. AZ Mohammed, AN Manasseh, BM Mandong, ST Edino. Abstract. Background:Malignant melanoma is a fatal skin cancer that is curable when detected and treated early. Recent reports indicate a rising incidence globally. This study aims at identifying the ...

  20. Intraoral malignant melanoma | Babburi | Nigerian Medical Journal

    African Journals Online (AJOL)

    Primary oral mucosal melanoma is a rare aggressive neoplasm and accounts for only 0.2‑8% of all reported melanomas. It is a malignant neoplasm of melanocytes that may arise from a benign melanocytic lesion or de novo from melanocytes within normal skin or mucosa. It is considered to be the most deadly and ...

  1. Towards new therapeutic approaches for malignant melanoma.

    Science.gov (United States)

    Pacheco, Ivan; Buzea, Cristina; Tron, Victor

    2011-11-01

    Recent progress in understanding the molecular mechanisms of the initiation and progression of melanoma has created new opportunities for developing novel therapeutic modalities to manage this potentially lethal disease. Although at first glance, melanoma carcinogenesis appears to be a chaotic system, it is indeed, arguably, a deterministic multistep process involving sequential alterations of proto-oncogenes, tumour suppressors and miRNA genes. The scope of this article is to discuss the most recent and significant advances in melanoma molecular therapeutics. It is apparent that using single agents targeting solely individual melanoma pathways might be insufficient for long-term survival. However, the outstanding results on melanoma survival observed with novel selective inhibitors of B-RAF, such as PLX4032 give hope that melanoma can be cured. The fact that melanoma develops acquired resistance to PLX4032 emphasises the importance of simultaneously targeting several pathways. Because the most striking feature of melanoma is its unsurpassed ability to metastasise, it is important to implement newer systems for drug delivery adapted from research on stem cells and nanotechnology.

  2. Checkpoint Inhibitors Hold Promise for Rare Melanoma

    Science.gov (United States)

    Patients with a rare form of melanoma, called desmoplastic melanoma, may be particularly likely to benefit from immune checkpoint inhibitors, a new study shows. As this Cancer Currents post explains, an NCI-sponsored clinical trial is already testing one such drug, pembrolizumab (Keytruda) in patients with this cancer.

  3. Mistletoe in the treatment of malignant melanoma

    Directory of Open Access Journals (Sweden)

    Esin Sakallı Çetin

    2014-03-01

    Full Text Available Malignant melanoma is a malignant neoplasia drives from melanocytes. Malignant melanoma, the most causing death, is seen in the third place at skin cancer. Malignant melanoma shows intrinsic resistance to chemotherapeutic agents and variability in the course of the disease which are distinct features separating from other solid tumors. These features prevent the development and standardization of non-surgical treatment models of malignant melanoma. Although there is a large number of chemotherapeutic agents used in the treatment of metastatic malignant melanoma, it hasn’t been demonstrated the survival advantage of adjuvant treatment with chemotherapeutic agents. Because of the different clinical course of malignant melanoma, the disease is thought to be closely associated with immune system. Therefore, immunomodulatory therapy models were developed. Mistletoe stimulates the immune system by increasing the number and activity of dendritic cells, thus it has been shown to effect on tumor growth and metastasis of malignant melanoma patient. Outlined in this review are the recent developments in the understanding the role of mistletoe as a complementary therapy for malignant melanoma. J Clin Exp Invest 2014; 5 (1: 145-152

  4. An Internship May Not Be Enough: Enhancing Bioscience Industry Job Readiness through Practicum Experiences

    Directory of Open Access Journals (Sweden)

    Jason M. Cramer

    2017-05-01

    Full Text Available In contrast to the narrowing of options in academic careers, the bioscience industry offers robust employment opportunities for STEM-trained workers, especially those who display both scientific and business talent. Unfortunately, traditional science programs typically lack curricular features that develop this type of worker. The North Carolina State University Master of Microbial Biotechnology (MMB program facilitates industry-specific experiential learning to fill this training gap. Similar programs often rely on a single industry internship to provide students relevant work experience, but completion of one internship might not suffice to position students for employment in a highly competitive job market. The MMB program requires students to complete an internship and three practicum projects in an industry setting, to promote development of key skills in a variety of areas, to build confidence in the ability to perform initial job duties, and to establish a more extensive work history in industry. In this Perspective we discuss an unmet need in undergraduate and graduate STEM education that can be filled by incorporating a similar set of industry-specific work experiences for students who desire to transition from academe into the life science industry.

  5. Predictors of Taiwanese baccalaureate nursing students' physio-psycho-social responses during clinical practicum.

    Science.gov (United States)

    Chen, Ya-Wen; Hung, Chich-Hsiu

    2014-01-01

    The nursing educational process may contribute to stress in nursing students, particularly during clinical rotations. This descriptive study explored the relationships between perceived stress, coping behaviors, personality traits, and physio-psycho-social responses in a clinical practicum among baccalaureate nursing students and identified predictors for physio-psycho-social responses. A cross-sectional design was employed. One hundred and one juniors enrolled in a four-year baccalaureate nursing program in Taiwan participated in this study. Four structured questionnaires were utilized to collect data. Multiple regression analysis showed that three predictors accounted for 53.2% of the variance in students' physio-psycho-social responses, including perceived stress, students' gender, and personality traits. The implication for nursing educators is providing immediate assistance and appropriate support to guide students through difficult learning when they need. Nursing instructors also should pay attention to students' gender-linked differences and be aware of individuals' personality traits, especially those with emotional instability, unsocial behaviors, and depressive signs. Copyright © 2013 Elsevier Ltd. All rights reserved.

  6. Practicum without borders: a case study of intercultural and pedagogical action and reflection

    Directory of Open Access Journals (Sweden)

    Ana IGLESIAS RODRÍGUEZ

    2013-07-01

    Full Text Available Teacher training schemes of the present 21st century ask for a new contextualization of good educational practice under frameworks of planetary scale which serve as tools aimed at interpreting culture-bound formation tracks designed for prospective teachers. The present case shows some of the opportunities and challenges of an International Practicum jointly organized by the University of Salamanca and several u.k. educational institutions. Besides their direct confrontation with culture as a living experience of diversity, the numerous agents involved in this programme were engaged in a dialogue between different pedagogical perspectives which cross-fertilized processes of teaching collaboration, mutual inquiry and a thorough rethink of areas of common linguistic, pedagogical and cultural interest. We hold that this fruitful conversation crosses borders while it offers, per se, an educational model of cohesiveness for it places the intercultural dimension at the heart of life-long education that can shape the profile of today’s European teachers.

  7. VOICES OF PRE-SERVICE ENGLISH TEACHERS: REFLECTING MOTIVATIONS DURING PRACTICUM LEARNING

    Directory of Open Access Journals (Sweden)

    PAULUS KUSWANDONO

    2014-07-01

    Full Text Available After Dewey (1933 and Schön (1983, 1987, education scholars began to look further at the concepts of reflection for learning. Following these concepts, there have been plenty of studies on reflection, particularly those discussing teachers’ classroom experiences and their endeavour to develop professional skills. However, educational practitioners in Indonesia (as in the rest of the world often criticise preservice teachers’ (PSTs lack of content knowledge, which they claim should be ‘prioritised’ during a teacher education course. Such pressing situations may have made it difficult to model or experience reflective practice. Against these odds, this research paper addresses issues related to the identity and professional development of thirteen English PSTs during their campus and school-based practicum in an Indonesian university. This study collected empirical data through PSTs’ reflective journals, questionnaires, individual interviews, focus group discussion, and autobiography. The study examines problems encountered by PSTs, namely their motivations to become teachers. This study signifies that teacher education needs to provide more reflective dialogues to shape PSTs’ identity and professionalism.

  8. Primary malignant melanoma of aryepiglottic fold | Chhabra | Ghana ...

    African Journals Online (AJOL)

    Background: Primary malignant melanoma rarely arises from noncutaneous tissues that contain melanocytes. Head and neck mucosal melanomas account for 0.7% to 3.8% of all melanomas. Here we report a case of primary malignant melanoma of aryepiglottic fold. Result: Here we reported a case of primary malignant ...

  9. Progression of cutaneous melanoma: implications for treatment

    Science.gov (United States)

    Leong, Stanley P. L.; Mihm, Martin C.; Murphy, George F.; Hoon, Dave S. B.; Kashani-Sabet, Mohammed; Agarwala, Sanjiv S.; Zager, Jonathan S.; Hauschild, Axel; Sondak, Vernon K.; Guild, Valerie; Kirkwood, John M.

    2015-01-01

    The survival rates of melanoma, like any type of cancer, become worse with advancing stage. Spectrum theory is most consistent with the progression of melanoma from the primary site to the in-transit locations, regional or sentinel lymph nodes and beyond to the distant sites. Therefore, early diagnosis and surgical treatment before its spread is the most effective treatment. Recently, new approaches have revolutionized the diagnosis and treatment of melanoma. Genomic profiling and sequencing will form the basis for molecular taxonomy for more accurate subgrouping of melanoma patients in the future. New insights of molecular mechanisms of metastasis are summarized in this review article. Sentinel lymph node biopsy has become a standard of care for staging primary melanoma without the need for a more morbid complete regional lymph node dissection. With recent developments in molecular biology and genomics, novel molecular targeted therapy is being developed through clinical trials. PMID:22892755

  10. From Melanocyte to Metastatic Malignant Melanoma

    Directory of Open Access Journals (Sweden)

    Bizhan Bandarchi

    2010-01-01

    Full Text Available Malignant melanoma is one of the most aggressive malignancies in human and is responsible for almost 60% of lethal skin tumors. Its incidence has been increasing in white population in the past two decades. There is a complex interaction of environmental (exogenous and endogenous, including genetic, risk factors in developing malignant melanoma. 8–12% of familial melanomas occur in a familial setting related to mutation of the CDKN2A gene that encodes p16. The aim of this is to briefly review the microanatomy and physiology of the melanocytes, epidemiology, risk factors, clinical presentation, historical classification and histopathology and, more in details, the most recent discoveries in biology and genetics of malignant melanoma. At the end, the final version of 2009 AJCC malignant melanoma staging and classification is presented.

  11. A rare case of rynopharyngeal melanoma

    Directory of Open Access Journals (Sweden)

    Francesco Grecchi

    2012-01-01

    Full Text Available Primary mucosal melanomas (MM of the head and neck region constitute 0.5-2% of all malignant melanomas. The rynopharynx is a region that is less often involved by malignant melanomas. Because most of mucosal melanotic lesions are painless in their early stages, the diagnosis is unfortunately often delayed until symptoms resulting from ulceration, growth, and/or bleeding are noted. Here, we document the rare case of a malignant rynopharynx melanoma of a 43 year old woman. Its treatment and the pertinent literature are discussed. No complication was recorded in the post-operative period and no further surgery was performed. The follow up showed no recurrence in the same position and with the same characteristics, even after six years. Mucosal melanomas are aggressive tumours and the prognosis in these patients is poor. Clinicians must use treatment strategies that provide functional benefit, so as to maintain quality of life without excessive toxicity.

  12. Alpha particles for treatment of disseminated melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Link, E.M. [London University (United Kingdom)

    2010-07-01

    Invading melanoma spreads to local and unpredictable distant location at the early stages of its development. It is justifiable, therefore, to classify the disease as a systemic disorder. This requires a systemic treatment that reaches all melanoma cells irrespective of whether they are singly dispersed and in circulation or already forming solid tumours of various sizes. Targeted radiotherapy affects directly and selectively cancer cells provided an appropriate radionuclide and its carrier are chosen. Melanoma is a pigmented tumour. Methylene blue (MTB)) accumulates selectively in melanoma cells due to its exceptionally high affinity to melanin. MTB serves, therefore, as a carrier for radionuclides. {sup 211}At-MTB has proved to be particularly effective in treating disseminated melanoma when administered systemically and, at the same time, non-toxic to normal non-pigmented and pigmented organs. (authors)

  13. Alpha particles for treatment of disseminated melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Link, E.M. [London Univ. (United Kingdom)

    2010-11-15

    Invading melanoma spreads to local and unpredictable distant location at the early stages of its development. It is justifiable, therefore to classify the disease as a systemic disorder. This requires a systemic treatment that reaches all melanoma cells irrespective of whether they are singly dispersed and in circulation or already forming solid tumours of various sizes. Targeted radiotherapy affects directly and selectively cancer cells provided an appropriate radionuclide and its carrier are chosen. Melanoma is a pigmented tumour. Methylene blue (MTB) accumulates selectively in melanoma cells due to its exceptionally high affinity to melanin. MTB serves, therefore, as a carrier for radionuclides. {sup 211}At-MTB has proved to be particularly effective in treating disseminated melanoma when administered systemically and, at the same time, non-toxic to normal non-pigmented and pigmented organs. (author)

  14. Nanomechanical analysis of pigmented human melanoma cells.

    Science.gov (United States)

    Sarna, Michal; Zadlo, Andrzej; Pilat, Anna; Olchawa, Magdalena; Gkogkolou, Paraskevi; Burda, Kvetoslava; Böhm, Markus; Sarna, Tadeusz

    2013-09-01

    Based on hitherto measurements of elasticity of various cells in vitro and ex vivo, cancer cells are generally believed to be much softer than their normal counterparts. In spite of significant research efforts on the elasticity of cancer cells, only few studies were undertaken with melanoma cells. However, there are no reports concerning pigmented melanoma cells. Here, we report for the first time on the elasticity of pigmented human melanoma cells. The obtained data show that melanin significantly increases the stiffness of pigmented melanoma cells and that the effect depends on the amount of melanin inside the cells. The dramatic impact of melanin on the nanomechanical properties of cells puts into question widely accepted paradigm about all cancer cells being softer than their normal counterparts. Our findings reveal significant limitations of the nanodiagnosis approach for melanoma and contribute to better understanding of cell elasticity. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  15. UVEAL MELANOMA EXTENSION TO THE OPTIC CHIASM.

    Science.gov (United States)

    Abdellatief, Amro; Pulido, Jose S; Bartley, George B; Salomao, Diva R; Quinn, Timothy A

    2016-01-01

    Case report describing a patient who developed intracranial extension of a uveal melanoma through the optic nerve. We reviewed the patient's medical history and images. A 41-year-old woman who was blind in one eye had a uveal melanoma that extended through the optic nerve into the optic chiasm and involved the hypophysis. The patient then developed metastasis. The patient developed uveal melanoma extension into the optic chiasm through the optic nerve resulting in a visual field defect in the fellow eye. Uveal melanoma extension through the optic nerve is a devastating complication, which occurs anywhere from 0.6% to 3.7% in patients with uveal melanoma. If enucleation of the affected eye is performed, a representative portion of the optic nerve should be excised to decrease the risk of extension. Patients with phthisical eyes should undergo appropriate imaging techniques to prevent a missed diagnosis of optic nerve involvement.

  16. Nodular skin melanomas and dermatoscopic diagnostic therein

    Directory of Open Access Journals (Sweden)

    M. V. Zhuchkov

    2016-01-01

    Full Text Available Aim. The study of dermatoscopic pattern characteristics of nodular melanoma with the use of modified Kittler’s pattern analysis. Materials and methods. Clinical and dermatoscopis images of 127 patients with histologically distinctive nodular form of skin melanoma were examined. Nonpolarized dermoscopy of nodular melanoma foci was carried out to patients. Interpretation of obtained dermatoscopic images was performed with the use of pattern analysis modified by Harold Kittler. Main results. The two most important dermatoscopic features of nodular melanoma that distinguish it from other clinical types of this malignant tumor were revealed in our investigation: 1 the prevalence of dermatoscopis images with one pattern (structureless; 2 the prevalence of “grey dots, circles, clods” and “black peripheral dots and clods” as main features of nodular melanoma.

  17. Melanoma Surveillance in the US: Collecting Melanoma Data

    Centers for Disease Control (CDC) Podcasts

    2011-10-19

    This podcast accompanies the publication of a series of articles on melanoma surveillance in the United States, available in the November supplement edition of the Journal of the American Academy of Dermatology. Dr. Suephy Chen, a dermatologist from Emory University, discusses why the articles are important, as well as the need to increase dermatologists’ awareness of cancer registries and reporting requirements.  Created: 10/19/2011 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 10/19/2011.

  18. Studying the pelletization of rosseta ilmenite concentrate with coke breeze using molasses and reduction kinetics of produced pellets at 800-1150ºC

    Directory of Open Access Journals (Sweden)

    El-Hussiny N.A.

    2012-01-01

    Full Text Available Ilmenite ore fine and coke breeze as reduced material which were pelletized with different amounts of molasses were studied in this investigation. The produced pellets at optimum condition were reduced in nitrogen atmosphere at temperature range 800-1150ºC to determine the controlling mechanism. The reduction indicated that the reduction rates increased as the temperature increased and the controlling mechanism of reaction rate is solid-solid reaction.

  19. A Tropical Lake Breeze System : The Effect on Surface NO, NO2, O3, and CO2 Mixing Ratios

    Science.gov (United States)

    Lima Moura, M. A.; Eça D'Almeida Rocha, C. H.; Trebs, I.; Andreae, M. O.; Meixner, F. X.

    2003-04-01

    During the Cooperative LBA Airborne Regional Experiment 2001 (CLAIRE2001, July 2001), we investigated diel variations of nitric oxide (NO), nitrogen dioxide (NO_2), ozone (O_3) and carbon dioxide (CO_2) mixing ratios at Balbina Limnological Station (01^o55'994''S, 59^o28'071''W, Amazonia,Brazil). We applied sensitive and species-specific chemiluminescence (NO, NO_2, O_3) and NDIR (CO_2) analysers to record ambient mixing ratios on 1 min intervals. Simultaneously, we extensively monitored (micro-)meteorological qauntities (air temperature, relative humidity, wind speed and -direction, thermal stratification, rainfall intensity, soil temperatures and moisture, as well as radiation fluxes (global, net, short wave, NO_2 photolysis, and photosynthetic active)). Balbina Limnological Station is located just a few hundred meters south of a 2.360 km^2 hydroelectric power dam (Usina Hidrelétrica de Balbina) and about 100m north from the edge of a primary rainforest. Marked differences in surface albedo and heat storage capacity generate a local wind system, the lake breeze, which advects air from the dam (09:00 to 15:00 local) and from the rainforest (18:00 to 06:00 local), respectively. Generally, we observed marked diel variations of NO, NO_2, O_3, and CO_2 (high/low levels during night/day) and O_3 (low/high levels during night/day). Especially in the tropics, this behaviour is usually related to (a) accumulation of soil emissions (NO, CO_2), chemical reactions (NO, from NO_2-O_3 reaction) and surface destruction (O_3) in a shallow and strong nocturnal boundary layer inversion, and (b) to soil emission (NO), photochemical reactions (NO-NO_2-O_3), dry deposition/plant uptake (NO_2, O_3, and CO_2) and strong turbulent vertical mixing in the daytime mixed layer. However, under the specific conditions of the lake breeze soil emission and dry deposition/ plant uptake can be neglected during daytime. Consequently, the investigation of daytime mixing ratios can be confined to

  20. The role of bay breezes and regional transport on a high surface ozone episode during the Houston, Texas DISCOVER-AQ field campaign

    Science.gov (United States)

    Loughner, C.; Follette-Cook, M. B.; Pickering, K. E.; Estes, M. J.

    2014-12-01

    The highest observed surface ozone concentrations in the Houston metropolitan area in 2013 occurred on September 25, which coincided with the Texas DISCOVER-AQ (Deriving Information on Surface Conditions from Column and Vertically Resolved Observations Relevant to Air Quality) field campaign. Surface ozone was elevated throughout the Houston metropolitan area. Maximum 8-hour average ozone peaked along the western shore of Galveston Bay, reaching 124 ppbv, almost 50 ppbv above the current EPA standard of 75 ppbv, at La Porte Sylvan Beach. Continental air pollution from the north and northeast was transported into the Houston metropolitan area where it mixed with locally generated emissions. A bay breeze circulation formed causing pollutants that were transported out over the water in the morning to recirculate back inland where they mixed with freshly emitted pollution near the bay breeze convergence zone. The highest surface ozone concentrations were reported near the bay breeze front at La Porte Sylvan Beach. This ozone episode will be presented using measurements made during the DISCOVER-AQ field campaign and WRF and CMAQ model simulations.

  1. Sox2 is not required for melanomagenesis, melanoma growth and melanoma metastasis in vivo.

    Science.gov (United States)

    Cesarini, V; Guida, E; Todaro, F; Di Agostino, S; Tassinari, V; Nicolis, S; Favaro, R; Caporali, S; Lacal, P M; Botti, E; Costanzo, A; Rossi, P; Jannini, E A; Dolci, S

    2017-08-01

    Melanoma is a dangerous form of skin cancer derived from the malignant transformation of melanocytes. The transcription factor SOX2 is not expressed in melanocytes, however, it has been shown to be differentially expressed between benign nevi and malignant melanomas and to be essential for melanoma stem cell maintenance and expansion in vitro and in xenograft models. By using a mouse model in which BRaf V600E mutation cooperates with Pten loss to induce the development of metastatic melanoma, we investigated if Sox2 is required during the process of melanomagenesis, melanoma growth and metastasis and in the acquisition of resistance to BRAF inhibitors (BRAFi) treatments. We found that deletion of Sox2 specifically in Pten null and BRafV600E-expressing melanocytes did not prevent tumor formation and did not modify the temporal kinetics of melanoma occurrence compared to Sox2 wt mice. In addition, tumor growth was similar between Sox2 wt and Sox2 deleted (del) melanomas. By querying publicly available databases, we did not find statistically significant differences in SOX2 expression levels between benign nevi and melanomas, and analysis on two melanoma patient cohorts confirmed that Sox2 levels did not significantly change between primary and metastatic melanomas. Melanoma cell lines derived from both Sox2 genotypes showed a similar sensitivity to vemurafenib treatment and the same ability to develop vemurafenib resistance in long-term cultures. Development of vemurafenib resistance was not dependent on SOX2 expression also in human melanoma cell lines in vitro. Our findings exclude an oncogenic function for Sox2 during melanoma development and do not support a role for this transcription factor in the acquisition of resistance to BRAFi treatments.

  2. [An experience applying the teaching strategies of cooperative learning and creative thinking in a mental-health nursing practicum for undergraduates at a technical college].

    Science.gov (United States)

    Huang, Yu-Hsien; Lin, Mei-Feng; Ho, Hsueh-Jen; Chang, Lu-Na; Chen, Shiue

    2015-04-01

    Lack of knowledge and experience is prevalent in undergraduate students who are taking their clinical practicum for mental-health nursing. This issue negatively affects the learning process. This article shares an experience of implementing a practicum-teaching program. This program was developed by the authors to facilitate the cooperative learning and clinical care competence of students. A series of multidimensional teaching activities was designed by integrating the strategies of peer cooperation and creative thinking to promote group and individual learning. Results indicate that the program successfully encouraged the students to participate more actively in the learning process. Additionally, the students demonstrated increased competence in empathetic caring toward patients, stronger friendship relationships with peers, and improved self-growth. The authors hope this teaching program provides a framework to increase the benefits for students of participating in clinical practicums and provides a teaching reference for clinical instructors.

  3. Current management and novel agents for malignant melanoma

    Directory of Open Access Journals (Sweden)

    Lee Byung

    2012-02-01

    Full Text Available Abstract Advanced malignant melanoma remains a challenging cancer. Over the past year, there have been 3 agents approved for treatment of melanoma by Food and Drug Administration. These include pegylated interferon alpha-2b for stage III melanoma, vemurafenib for unresectable or metastatic melanoma with BRAF V600E mutation, and ipilimumab for treatment of unresectable or metastatic melanoma. This review will also update on the development of novel agents, including tyrosine kinase inhibitors and adoptive cellular therapy.

  4. Glaucoma secundario a melanoma uveal

    Directory of Open Access Journals (Sweden)

    Nairovys Gómez Martínez

    2017-09-01

    Full Text Available Introducción: Los tumores localizados en iris y cuerpo ciliar son poco frecuentes y puede ser valorada su resección local como alternativa terapéutica. El melanoma uveal representa el 79-81% de los melanomas oculares y el 3-5% de todos los melanomas. Objetivo: Dar a conocer el caso de una patología infrecuente con pocos casos reportados en la literatura, enfatizar su importancia dentro de los diagnósticos diferenciales y del estudio histopatológico. Descripción del caso: Paciente femenina de 47 años de edad, quien acudió a la consulta de oftalmología, para valoración de una lesión pigmentada en endotelio corneal y en iris asociada a hipertensión ocular y pérdida de la agudeza visual en el ojo izquierdo de cuatro meses de evolución. La biomicroscopía ultrasónica confirmó la presencia de una masa iridiana, localizada en la periferia del iris. El estudio anatomopatológico mostró una proliferación de células névicas pleomórficas que reemplazaban el estroma normal del iris. Conclusiones: En pacientes que presentan una clínica de glaucoma unilateral refractario a tratamiento farmacológico junto con dispersión de pigmento es importante una exploración exhaustiva destacando el papel de la biomicroscopía ultrasónica.

  5. Future perspectives in melanoma research

    Directory of Open Access Journals (Sweden)

    Paolo A. Ascierto

    2016-11-01

    Full Text Available Abstract The sixth “Melanoma Bridge Meeting” took place in Naples, Italy, December 1st–4th, 2015. The four sessions at this meeting were focused on: (1 molecular and immune advances; (2 combination therapies; (3 news in immunotherapy; and 4 tumor microenvironment and biomarkers. Recent advances in tumor biology and immunology has led to the development of new targeted and immunotherapeutic agents that prolong progression-free survival (PFS and overall survival (OS of cancer patients. Immunotherapies in particular have emerged as highly successful approaches to treat patients with cancer including melanoma, non-small cell lung cancer (NSCLC, renal cell carcinoma (RCC, bladder cancer, and Hodgkin’s disease. Specifically, many clinical successes have been using checkpoint receptor blockade, including T cell inhibitory receptors such as cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4 and the programmed cell death-1 (PD-1 and its ligand PD-L1. Despite demonstrated successes, responses to immunotherapy interventions occur only in a minority of patients. Attempts are being made to improve responses to immunotherapy by developing biomarkers. Optimizing biomarkers for immunotherapy could help properly select patients for treatment and help to monitor response, progression and resistance that are critical challenges for the immuno-oncology (IO field. Importantly, biomarkers could help to design rational combination therapies. In addition, biomarkers may help to define mechanism of action of different agents, dose selection and to sequence drug combinations. However, biomarkers and assays development to guide cancer immunotherapy is highly challenging for several reasons: (i multiplicity of immunotherapy agents with different mechanisms of action including immunotherapies that target activating and inhibitory T cell receptors (e.g., CTLA-4, PD-1, etc.; adoptive T cell therapies that include tissue infiltrating lymphocytes (TILs, chimeric

  6. Melanoma early detection and awareness

    DEFF Research Database (Denmark)

    Wainstein, Alberto; Algarra, Salvador Martin; Bastholt, Lars

    2014-01-01

    Risk factors for melanoma are well known and have guided plans for primary and secondary prevention. The presentation of the disease, however, varies widely depending on the geographic area, ethnicity, and socioeconomic status. For this reason, many countries have developed specific strategies to...... are trying to implement similar measures. Future efforts to further improve the efficacy of preventive strategies should focus on populations that usually escape campaigns, such as elderly men and people with low socioeconomic status. Fast-growing tumors also require specific attention....

  7. Severe Weather Caused by Heat Island and Sea Breeze Effects in the Metropolitan Area of São Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Felipe Vemado

    2016-01-01

    Full Text Available The Metropolitan Area of São Paulo (MASP is one of the most populated regions of the planet with one of the largest impervious regions as well. This research work aims to characterize MASP heat island (HI effect and its interaction with the local sea breeze (SB inflow in rainfall amounts and deep convection. The combined SB-HI produces direct circulation over the MASP and produces severe weather and socioeconomic impacts. All SB-HI episodes between 2005 and 2008 are identified and analyzed with surface and upper air measurements, weather radar, and satellite data. The current work indicates that intense SB-HI episodes are related to air and dew point temperatures above 30°C and 20°C, respectively, right after the passage of the SB front over MASP. Results indicate that the precipitation related to SB-HI episodes is up to 600 mm or about four times higher than that in rural or less urbanized areas in its surroundings. Measurements indicate that 74% of SB-HI episodes are related to NW winds in earlier afternoon hours. Moving cold fronts in southern Brazil tend to intensify the SB-HI circulation in MASP. A conceptual model of these patterns is presented in this paper.

  8. The Helium Warm Breeze in IBEX Observations As a Result of Charge-exchange Collisions in the Outer Heliosheath

    Energy Technology Data Exchange (ETDEWEB)

    Bzowski, Maciej; Kubiak, Marzena A.; Czechowski, Andrzej; Grygorczuk, Jolanta, E-mail: bzowski@cbk.waw.pl [Space Research Centre PAS (CBK PAN) Bartycka 18A 00-716 Warsaw (Poland)

    2017-08-10

    We simulated the signal due to neutral He atoms, observed by the Interstellar Boundary Explorer ( IBEX ), assuming that charge-exchange collisions between neutral He atoms and He{sup +} ions operate everywhere between the heliopause and a distant source region in the local interstellar cloud, where the neutral and charged components are in thermal equilibrium. We simulated several test cases of the plasma flow within the outer heliosheath (OHS) and investigated the signal generation for plasma flows both in the absence and in the presence of the interstellar magnetic field (ISMF). We found that a signal in the portion of IBEX data identified as being due to the Warm Breeze (WB) does not arise when a homogeneous plasma flow in front of the heliopause is assumed, but it appears immediately when any reasonable disturbance in its flow due to the presence of the heliosphere is assumed. We obtained a good qualitative agreement between the data selected for comparison and the simulations for a model flow with the velocity vector of the unperturbed gas and the direction and intensity of magnetic field adopted from recent determinations. We conclude that direct-sampling observations of neutral He atoms at 1 au from the Sun are a sensitive tool for investigating the flow of interstellar matter in the OHS, that the WB is indeed the secondary population of interstellar helium, which was hypothesized earlier, and that the WB signal is consistent with the heliosphere distorted from axial symmetry by the ISMF.

  9. Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors

    DEFF Research Database (Denmark)

    Boyle, Jenny L; Haupt, Helen M; Stern, Jere B

    2002-01-01

    CONTEXT: Pathologists may encounter problems in the differential diagnosis of malignant melanoma, spindle and epithelioid neoplasms of peripheral nerves, and fibrohistiocytic tumors. Tyrosinase has been demonstrated to be a sensitive marker for melanoma. OBJECTIVE: To determine the specificity...... of tyrosinase expression in the differential diagnosis of melanoma, desmoplastic melanoma, and peripheral nerve sheath tumors. DESIGN: Immunoreactivity for tyrosinase, HMB-45 (anti-gp100 protein), S100 protein, CD34, and vimentin was studied in 70 tumors, including 15 melanomas (5 desmoplastic, 4 amelanotic, 6...... at 121 degrees C. RESULTS: All melanomas demonstrated positive immunostaining for tyrosinase, HMB-45, and S100 protein. Immunoreactivity for HMB-45 was generally stronger than that for tyrosinase in amelanotic lesions and significantly stronger in 1 of the desmoplastic lesions. The 4 pigmented...

  10. Pregnancy promotes melanoma metastasis through enhanced lymphangiogenesis.

    Science.gov (United States)

    Khosrotehrani, Kiarash; Nguyen Huu, Sau; Prignon, Aurélie; Avril, Marie-Françoise; Boitier, Françoise; Oster, Michèle; Mortier, Laurent; Richard, Marie-Aleth; Maubec, Eve; Kerob, Delphine; Mansard, Sandrine; Merheb, Charbel; Moguelet, Philippe; Nassar, Dany; Guégan, Sarah; Aractingi, Selim

    2011-04-01

    The relationships of pregnancy and melanoma have been debatable. Our aim was to assess the influence of gestation on the course of melanoma in a classic murine model of tumor progression and in women. B16 mouse melanoma cells were injected in nonpregnant or pregnant mice on day 5 of gestation. Animals were evaluated for tumor progression, metastases, and survival. Tumor sections were analyzed for lymphatic and blood vessel number and relative surface and expression of angiogenic growth factors. Finally, primary melanomas from pregnant and nonpregnant women, matched for age and tumor thickness, were also considered. Tumor growth, metastasis, and mortality were increased in B16-injected pregnant mice. Tumors displayed an increase in intratumoral lymphangiogenesis during gestation. This increased lymphatic angiogenesis was not observed in normal skin during gestation, showing its specificity to the tumor. An analysis of melanoma from pregnant and matched nonpregnant women showed a similar increase in lymphatic vessels. Tumors from pregnant mice had increased expression of vascular endothelial growth factor A at the RNA and protein levels. The increased vascular endothelial growth factor A production by melanoma cells could be reproduced in culture using pregnant mouse serum. In conclusion, pregnancy results in increased lymphangiogenesis and subsequent metastasis. Caution should be applied in the management of patients with advanced-stage melanoma during gestation. Copyright © 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  11. Non Melanoma Skin Cancer Pathogenesis Overview.

    Science.gov (United States)

    Didona, Dario; Paolino, Giovanni; Bottoni, Ugo; Cantisani, Carmen

    2018-01-02

    (1) Background: Non-melanoma skin cancer is the most frequently diagnosed cancer in humans. The process of skin carcinogenesis is still not fully understood. However, several studies have been conducted to better explain the mechanisms that lead to malignancy; (2) Methods: We reviewed the more recent literature about the pathogenesis of non-melanoma skin cancer focusing on basal cell carcinomas, squamous cell carcinoma and actinic keratosis; (3) Results: Several papers reported genetic and molecular alterations leading to non-melanoma skin cancer. Plenty of risk factors are involved in non-melanoma skin cancer pathogenesis, including genetic and molecular alterations, immunosuppression, and ultraviolet radiation; (4) Conclusion: Although skin carcinogenesis is still not fully understood, several papers demonstrated that genetic and molecular alterations are involved in this process. In addition, plenty of non-melanoma skin cancer risk factors are now known, allowing for an effective prevention of non-melanoma skin cancer development. Compared to other papers on the same topic, our review focused on molecular and genetic factors and analyzed in detail several factors involved in non-melanoma skin cancer.

  12. Melanoma Brain Metastasis: Mechanisms, Models, and Medicine

    Science.gov (United States)

    Kircher, David A.; Silvis, Mark R.; Cho, Joseph H.; Holmen, Sheri L.

    2016-01-01

    The development of brain metastases in patients with advanced stage melanoma is common, but the molecular mechanisms responsible for their development are poorly understood. Melanoma brain metastases cause significant morbidity and mortality and confer a poor prognosis; traditional therapies including whole brain radiation, stereotactic radiotherapy, or chemotherapy yield only modest increases in overall survival (OS) for these patients. While recently approved therapies have significantly improved OS in melanoma patients, only a small number of studies have investigated their efficacy in patients with brain metastases. Preliminary data suggest that some responses have been observed in intracranial lesions, which has sparked new clinical trials designed to evaluate the efficacy in melanoma patients with brain metastases. Simultaneously, recent advances in our understanding of the mechanisms of melanoma cell dissemination to the brain have revealed novel and potentially therapeutic targets. In this review, we provide an overview of newly discovered mechanisms of melanoma spread to the brain, discuss preclinical models that are being used to further our understanding of this deadly disease and provide an update of the current clinical trials for melanoma patients with brain metastases. PMID:27598148

  13. Dermoscopy on subungual melanoma 

    Directory of Open Access Journals (Sweden)

    Grażyna Kamińska-Winciorek

    2013-05-01

    Full Text Available Subungual melanoma is a rare, but one of the diagnostically most difficult variants of melanoma. Unfortunately, due to its late detection, lack of an early reaction from the patient and diagnosis in advanced stages, subungual melanoma is deemed as a prognostically unfavorable variant of this malignancy. Diagnosis of subungual melanoma is very difficult to establish merely on the basis of clinical examination due to the resemblance of subungual hematoma to melanocytic nevus, fungal or bacterial infections. Dermoscopy seems to be the ideal diagnostic tool in the differential diagnosis of this life-threatening disease. Aims. To describe the basic aspects of dermoscopy of subungual melanoma and other conditions involving the nails. Methods. Review of medical database PubMed for the literature of the last 10 years on the dermoscopic patterns of subungual melanoma and other subungual diseases. Results. We collate the fundamental rules of performing dermoscopy in subungual melanoma, as well as basic dermoscopic features and diagnostic algorithms of selected subungual lesions requiring differentiation from melanoma. Conclusions. Dermoscopy is a safe, easily repeatable diagnostic method, and the knowledge of basic dermoscopic patterns of developing melanoma in subungual localization, along with the differential diagnosis of other diseases within the nail plate, will help not only dermatologists, but also the professionals of other specialties, such as surgeons, oncologists, orthopedists, and also general practitioners.

  14. Whole Body Melanoma Transcriptome Response in Medaka.

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    Manfred Schartl

    Full Text Available The incidence of malignant melanoma continues to increase each year with poor prognosis for survival in many relapse cases. To reverse this trend, whole body response measures are needed to discover collaborative paths to primary and secondary malignancy. Several species of fish provide excellent melanoma models because fish and human melanocytes both appear in the epidermis, and fish and human pigment cell tumors share conserved gene expression signatures. For the first time, we have examined the whole body transcriptome response to invasive melanoma as a prelude to using transcriptome profiling to screen for drugs in a medaka (Oryzias latipes model. We generated RNA-seq data from whole body RNA isolates for controls and melanoma fish. After testing for differential expression, 396 genes had significantly different expression (adjusted p-value <0.02 in the whole body transcriptome between melanoma and control fish; 379 of these genes were matched to human orthologs with 233 having annotated human gene symbols and 14 matched genes that contain putative deleterious variants in human melanoma at varying levels of recurrence. A detailed canonical pathway evaluation for significant enrichment showed the top scoring pathway to be antigen presentation but also included the expected melanocyte development and pigmentation signaling pathway. Results revealed a profound down-regulation of genes involved in the immune response, especially the innate immune system. We hypothesize that the developing melanoma actively suppresses the immune system responses of the body in reacting to the invasive malignancy, and that this mal-adaptive response contributes to disease progression, a result that suggests our whole-body transcriptomic approach merits further use. In these findings, we also observed novel genes not yet identified in human melanoma expression studies and uncovered known and new candidate drug targets for further testing in this malignant melanoma

  15. Plasma 25-Hydroxyvitamin D and Risk of Non-Melanoma and Melanoma Skin Cancer

    DEFF Research Database (Denmark)

    Afzal, Shoaib; Nordestgaard, Børge G; Bojesen, Stig E

    2013-01-01

    with increasing cumulative incidence of non-melanoma skin cancer (trend P=2 × 10(-15) and P=3 × 10(-17)) and melanoma skin cancer (P=0.003 and P=0.001). Multivariable adjusted hazard ratios of non-melanoma skin cancer were 5.04 (95% confidence interval (CI): 2.78-9.16) for 25-OH-vitD 50 vs. 60 years, 25-OH...

  16. Primary retroperitoneal melanoma presented in a rare extracutaneous site for malignant melanoma

    Directory of Open Access Journals (Sweden)

    Mohamed Alsharedi

    2016-10-01

    Full Text Available Malignant melanoma, as the name implies, is a malignant tumor of melanocytes, found in the skin, eyes, meningeal lining and the mucosal epithelium of the aero-digestive and genitourinary tracts. Malignant melanoma is typically skin malignancy, which rarely presents at extracutaneous site. Here we present a rare case of primary retroperitoneal melanoma and review the findings in comparison with other cases described in literature.

  17. Identification of an Immunogenic Subset of Metastatic Uveal Melanoma.

    Science.gov (United States)

    Rothermel, Luke D; Sabesan, Arvind C; Stephens, Daniel J; Chandran, Smita S; Paria, Biman C; Srivastava, Abhishek K; Somerville, Robert; Wunderlich, John R; Lee, Chyi-Chia R; Xi, Liqiang; Pham, Trinh H; Raffeld, Mark; Jailwala, Parthav; Kasoji, Manjula; Kammula, Udai S

    2016-05-01

    Uveal melanoma is a rare melanoma variant with no effective therapies once metastases develop. Although durable cancer regression can be achieved in metastatic cutaneous melanoma with immunotherapies that augment naturally existing antitumor T-cell responses, the role of these treatments for metastatic uveal melanoma remains unclear. We sought to define the relative immunogenicity of these two melanoma variants and determine whether endogenous antitumor immune responses exist against uveal melanoma. We surgically procured liver metastases from uveal melanoma (n = 16) and cutaneous melanoma (n = 35) patients and compared the attributes of their respective tumor cell populations and their infiltrating T cells (TIL) using clinical radiology, histopathology, immune assays, and whole-exomic sequencing. Despite having common melanocytic lineage, uveal melanoma and cutaneous melanoma metastases differed in their melanin content, tumor differentiation antigen expression, and somatic mutational profile. Immunologic analysis of TIL cultures expanded from these divergent forms of melanoma revealed cutaneous melanoma TIL were predominantly composed of CD8(+) T cells, whereas uveal melanoma TIL were CD4(+) dominant. Reactivity against autologous tumor was significantly greater in cutaneous melanoma TIL compared with uveal melanoma TIL. However, we identified TIL from a subset of uveal melanoma patients which had robust antitumor reactivity comparable in magnitude with cutaneous melanoma TIL. Interestingly, the absence of melanin pigmentation in the parental tumor strongly correlated with the generation of highly reactive uveal melanoma TIL. The discovery of this immunogenic group of uveal melanoma metastases should prompt clinical efforts to determine whether patients who harbor these unique tumors can benefit from immunotherapies that exploit endogenous antitumor T-cell populations. Clin Cancer Res; 22(9); 2237-49. ©2015 AACR. ©2015 American Association for Cancer Research.

  18. Teoria para o trabalho de expansão aplicada às brisas do nordeste Brasileiro Theory for expansion work applied to breezes of Northeast of Brazil

    Directory of Open Access Journals (Sweden)

    Clênia R. Alcântara

    2009-12-01

    Full Text Available Neste artigo investiga-se numericamente a interação entre brisas marítima-terrestre e de vale-montanha, que ocorrem no nordeste brasileiro devido à presença do Planalto da Borborema, aplicando o trabalho de expansão associado ao ramo inferior das circulações. Resultados da teoria da máquina térmica são comparados aos resultados 3D, obtidos com a versão brasileira do modelo RAMS. Os resultados indicaram que o efeito do contraste de temperatura no trabalho ligado às circulações (Wa, isoladamente, contribui para a formação de brisas marítimas mais intensas e de brisas terrestres menos intensas. Na realidade, o que se observa são brisas terrestres com intensidades iguais ou até maiores que das brisas marítimas. Assim, a contribuição da montanha para a intensidade das circulações de brisa no período noturno mostra-se extremamente não-linear. O trabalho de expansão que realmente está ligado às circulações, contribui em apenas 7% para o trabalho total. Dessa forma, a maior parte do trabalho total está associada ao trabalho de compressão que a atmosfera realiza para compensar a perda por resfriamento radiativo, e muito da energia disponibilizada para as circulações é gasta para vencer os processos dissipativos.The purpose of this work is to further understand the interactions between sea-land breeze and valley-mountain breeze that occur at the coast of Northeast Brazil due to the presence of the Borborema plateau, using the associated expansion work at the lower branch of these circulations. Results of the thermal machine theory are compared to the 3D results obtained from the Brazilian RAMS model version. The results indicate that the sole effect of temperature contrast on the work associated with circulations (Wa is more intense sea breezes and weaker land breezes. Actually, one can observe land breezes whose intensities are equal or even larger than sea breezes. Thus, the mountain contribution for the intensity of

  19. Coping strategies in melanoma patients.

    Science.gov (United States)

    Trapp, Michael; Trapp, Eva-Maria; Richtig, Erika; Egger, Josef Wilhelm; Zampetti, Anna; Sampogna, Francesca; Rohrer, Peter Michael; Komericki, Peter; Strimitzer, Tanja; Linder, Michael Dennis

    2012-11-01

    An observational, questionnaire-based, cross-sectional study was performed to assess whether differences in coping behaviour (positive and negative strategies) between patients with either a recent diagnosis of malignant melanoma (MM) or with benign dermatological disease, were predictive of the diagnosis. Coping strategies were assessed with the German version of the stress-coping questionnaire (SVF 120) in 46 inpatients for whom surgery was planned at the Department of Dermatology, Medical University of Graz, Austria. Subjects were divided into two groups: patients with non-metastatic MM, and patients with benign dermatological diseases (controls). The risk for the diagnosis "melanoma" decreased with higher values of "situation control" (p = 0.007) and increased with higher values of resignation (p = 0.035) and trivialisation (p = 0.039). More-over, the risk for having a MM with thickness > 1 mm decreased in patients with higher values in positive coping strategies (p psychological interventions to improve coping in patients with MM, as differences in coping behaviour seem to appear even in the non-metastatic stage of the disease.

  20. An analysis of clinical teacher behaviour in a nursing practicum in Taiwan.

    Science.gov (United States)

    Hsu, Li-Ling

    2006-05-01

    The aim of this study was to identify and assess the teaching behaviours (knowledge, attitudes and skills) observed in nurse educators as they taught in the clinical setting. Many quantitative studies have defined and evaluated teaching effectiveness in the clinical area. Some of these studies established instruments to evaluate faculty effectiveness in the clinical setting; however, they tended to be so broad that they were of limited use in understanding clinical teaching behaviours in nursing education. This study explored clinical teaching behaviours in a nursing practicum. Ten nurse educators taught 10 students in the medical-surgical unit at a hospital in Taiwan for about four weeks. Each teacher was observed by the researcher and one other observer for two days during regularly scheduled clinical teaching time. Data collection and analysis were done by a qualitative approach. Content analysis is a process of identifying, coding and categorizing the themes in the data. The themes of clinical teaching that emerged from data analysis included teaching aims (task-oriented and learner-centred), teacher competence (teacher knowledge, instructional strategies, planning learning experience, teaching priorities, feedback and caring) and teaching commitment (professional identity and giving of self). These findings offer a holistic blueprint of clinical teaching for nursing faculty members, which will enhance the quality of nursing education. Complexity in nursing education has increased as it is challenged to meet the needs of diverse populations in rapidly evolving and highly technical health-care settings. Clinical teachers must be enabled and empowered to provide students with appropriate knowledge and skills to meet the needs of patients. To develop students' professional nursing identity now and in the future, nurse educators have to commit themselves to both nursing and teaching in clinical settings. More nurses need to be prepared for careers in education at

  1. Gingival osteogenic melanoma in two dogs.

    Science.gov (United States)

    Ellis, Angela E; Harmon, Barry G; Miller, Debra L; Northrup, Nicole C; Latimer, Kenneth S; Uhl, Elizabeth W

    2010-01-01

    Osteogenic melanoma is a rare variant of metaplastic malignant melanoma in human medicine and appears to be a similarly rare variant in dogs. Two dogs with oral malignant melanoma with neoplastic bone formation are reported in this study. Both tumors were characterized by malignant melanocytes that transitioned into neoplastic bone at the deep margins of the neoplasm. Immunohistochemical analysis revealed S100- and Melan-A-positive neoplastic cells adjacent to, and occasionally embedded within, an osteoid and chondroblastic matrix. Scattered clusters of neoplastic cells were also positive for osteocalcin. The findings indicate that in dogs, as in humans, neoplastic melanocytes have metaplastic potential and can be osteogenic.

  2. Immunotherapy for advanced melanoma: future directions.

    Science.gov (United States)

    Valpione, Sara; Campana, Luca G

    2016-02-01

    As calculated by the meta-analysis of Korn et al., the prognosis of metastatic melanoma in the pretarget and immunological therapy era was poor, with a median survival of 6.2 and a 1-year life expectancy of 25.5%. Nowadays, significant advances in melanoma treatment have been gained, and immunotherapy is one of the promising approaches to get to durable responses and survival improvement. The aim of the present review is to highlight the recent innovations in melanoma immunotherapy and to propose a critical perspective of the future directions of this enthralling oncology subspecialty.

  3. A modified COMS plaque for iris melanoma

    Directory of Open Access Journals (Sweden)

    Daniel J. Scanderbeg

    2011-09-01

    Full Text Available Melanoma of the iris is a rare condition compared to posterior ocular tumors and in this case report we presenta 51-year-old female patient with diffuse iris melanoma. Traditional COMS (Collaborative Ocular Melanoma Studyplaques are used at our institution for radiation therapy, so a novel modification of the traditional plaque was requiredto allow better conformance with placement on the cornea. The usual silastic insert was machined to dimensions incompliance with the cornea, placed without incident, and treatment delivered with excellent patient tolerance of themodified plaque.

  4. Epidemiology of uveal melanomas in Moscow

    Directory of Open Access Journals (Sweden)

    E. E. Grishina

    2017-01-01

    Full Text Available Rationale: Melanoma of the uveal tract of the eye is among the most prevalent malignant intraocular tumors.Aim: To identify epidemiological characteristics of uveal melanoma in Moscow.Materials and methods: We performed a retrospective analysis of out-patient files and follow-up charts of patients with uveal melanoma in the Ophthalmological Clinical Hospital of the Department of Healthcare, Moscow, from 1977 to 2012.Results: Within 36 years, 2547 patients with uveal melanoma have been registered, at the age of 16 to 92 years. The male to female ratio was 1:1.5. The rate of patient referrals with subsequent diagnosis of uveal melanoma has not changed from 1977 to 2000 and was on average 1.07 persons per 100,000 of the adult population. From 2001 to 2012, there was some decline in the number of referrals with uveal melanoma to the average of 0.9 persons per 100,000 of the adult population. We analyzed survival among 359 patients with uveal melanoma after enucleation surgery of the eye; 37% of them were men (63.2 ± 1.8 years and 63% women (69.5 ± 2.7 years. Their 5-year metastasis-free survival was 65 ± 3%, whereas the 7-year survival was 60 ± 4%. The mean time to death was 5.5 years. There were no association between the life longevity and patients gender, but their survival was associated with the age of patients. The risk of death from metastatic uveal melanoma among patients above 60 years of age was on average 10% higher. After the enucleation surgery, patients with Т4 melanoma lived significantly less than those with Т1-3 tumor (5 and 6.5 years, respectively; р = 0.05.Conclusion: The rates of diagnosis of uveal melanoma at referrals within 36 years did not increased. Epidemiology of uveal melanoma in Moscow is characterized by a high proportion of elderly women. Shorter overall and metastasis-free survival of patients with uveal melanoma after the enucleation surgery depends from a higher proportion

  5. Nodular Melanoma Mimicking Keratoacanthoma: Lessons to learn.

    Science.gov (United States)

    Muthupalaniappen, Leelavathi; Das, Srijit; Md Nor, Norazirah; Ali, Siti A M

    2012-08-01

    A 67-year-old man of Chinese descent presented with a painless nodular lesion that had been present on his right forearm for the previous 3 months. A single, well-defined, dome-shaped, firm nodule with a central keratin plug surrounded by erythema was noted. Keratoacanthoma with secondary bacterial infection was suspected and the patient underwent an excision biopsy. Biopsy of the nodule and immunohistochemical staining supported a diagnosis of nodular malignant melanoma. It should be noted both that nodular malignant melanoma may present with a wide variety of clinical appearances, and that the lack of melanin pigment in nodular malignant melanoma may hinder the diagnosis of this aggressive tumour.

  6. Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma.

    Science.gov (United States)

    Simpson, R Mark; Bastian, Boris C; Michael, Helen T; Webster, Joshua D; Prasad, Manju L; Conway, Catherine M; Prieto, Victor M; Gary, Joy M; Goldschmidt, Michael H; Esplin, D Glen; Smedley, Rebecca C; Piris, Adriano; Meuten, Donald J; Kiupel, Matti; Lee, Chyi-Chia R; Ward, Jerrold M; Dwyer, Jennifer E; Davis, Barbara J; Anver, Miriam R; Molinolo, Alfredo A; Hoover, Shelley B; Rodriguez-Canales, Jaime; Hewitt, Stephen M

    2014-01-01

    Melanoma represents a significant malignancy in humans and dogs. Different from genetically engineered models, sporadic canine melanocytic neoplasms share several characteristics with human disease that could make dogs a more relevant preclinical model. Canine melanomas rarely arise in sun-exposed sites. Most occur in the oral cavity, with a subset having intra-epithelial malignant melanocytes mimicking the in situ component of human mucosal melanoma. The spectrum of canine melanocytic neoplasia includes benign lesions with some analogy to nevi, as well as invasive primary melanoma, and widespread metastasis. Growing evidence of distinct subtypes in humans, differing in somatic and predisposing germ-line genetic alterations, cell of origin, epidemiology, relationship to ultraviolet radiation and progression from benign to malignant tumors, may also exist in dogs. Canine and human mucosal melanomas appear to harbor BRAF, NRAS, and c-kit mutations uncommonly, compared with human cutaneous melanomas, although both species share AKT and MAPK signaling activation. We conclude that there is significant overlap in the clinical and histopathological features of canine and human mucosal melanomas. This represents opportunity to explore canine oral cavity melanoma as a preclinical model. © 2013 The Authors. Pigment Cell & Melanoma Research published by John Wiley & Sons Ltd.

  7. Obesity as a risk factor for malignant melanoma and non-melanoma skin cancer.

    Science.gov (United States)

    Karimi, K; Lindgren, T H; Koch, C A; Brodell, Robert T

    2016-09-01

    The dramatic increases in incidence of both obesity and many cancers including skin cancer emphasize the need to better understand the pathophysiology of both conditions and their connections. Melanoma is considered the fastest growing cancer and rates of non-melanoma skin cancer have also increased over the last decade. The molecular mechanisms underlying the association between obesity and skin cancer are not clearly understood but emerging evidence points to changes in the tumor microenvironment including aberrant cell signaling and genomic instability in the chronic inflammatory state many obese individuals experience. This article reviews the literature linking obesity to melanoma and non-melanoma skin cancer.

  8. Experimental boron neutron capture therapy for melanoma: Systemic delivery of boron to melanotic and amelanotic melanoma

    International Nuclear Information System (INIS)

    Coderre, J.A.; Glass, J.D.; Micca, P.; Greenberg, D.; Packer, S.

    1990-01-01

    The boron-containing melanin precursor analogue p-boronophenylalanine (BPA) has previously been shown to selectively deliver boron to pigmented murine melanomas when administered in a single intragastric dose. If boron neutron capture therapy is to become a clinically useful method of radiation therapy for human malignant melanoma, the boron carrier must be capable of delivering useful amounts of boron to remote tumor sites (metastases) and to poorly pigmented melanomas. The authors have now determined the ability of BPA to accumulate in several nonpigmented melanoma models including human melanoma xenografts in nude mice. The absolute amount of boron in the nonpigmented melanomas was about 50% of the observed in the pigmented counterparts but was still selectively concentrated in the tumor relative to normal tissues in amounts sufficient for effective neutron capture therapy. Single intragastric doses of BPA resulted in selective localization of boron in the amelanotic Greene melanoma carried in the anterior chamber of the rabbit eye and in a pigmented murine melanoma growing in the lungs. The ratio of the boron concentration in these tumors to the boron concentration in the immediately adjacent normal tissue was in the range of 3:1 to 4:1. These distribution studies support the proposal that boron neutron capture therapy may be useful as a regional therapy for malignant melanoma

  9. Nestin is expressed in HMB-45 negative melanoma cells in dermal parts of nodular melanoma.

    Science.gov (United States)

    Kanoh, Maho; Amoh, Yasuyuki; Tanabe, Kenichi; Maejima, Hideki; Takasu, Hiroshi; Katsuoka, Kensei

    2010-06-01

    Nestin, a marker of neural stem cells, is expressed in the stem cells of the mouse hair follicle. The nestin-expressing hair follicle stem cells can differentiate into neurons, glia, keratocytes, smooth muscle cells and melanocytes in vitro. These pluripotent nestin-expressing stem cells are keratin 15 (K15)-negative, suggesting that they are in a relatively undifferentiated state. Recent studies suggest that the epithelial stem cells are important in tumorigenesis, and nestin expression is thought to be important in tumorigenesis. In the present study, we examined the expression of the hair follicle and neural stem cell marker nestin, as well as S-100 and HMB-45, in melanoma. Nestin immunoreactivity was observed in the HMB-45-negative melanoma cells in all five cases of amelanotic nodular melanomas. Moreover, nestin immunoreactivity was observed in the dermal parts in seven of 10 cases of melanotic nodular melanomas. Especially, nestin immunoreactivity was observed in the HMB-45-negative melanoma cells in the dermal parts of all 10 cases of HMB-45-negative amelanotic and melanotic nodular melanomas. On the other hand, nestin expression was negative in 10 of 12 cases of superficial spreading melanoma. These results suggest that nestin is an important marker of HMB-45-negative melanoma cells in the dermal parts of patients with nodular melanoma.

  10. Anti-SEMA4D Monoclonal Antibody VX15/2503 With Nivolumab or Ipilimumab in Treating Patients With Stage III or IV Melanoma

    Science.gov (United States)

    2018-02-01

    Metastatic Melanoma; Stage III Cutaneous Melanoma AJCC v7; Stage IIIA Cutaneous Melanoma AJCC v7; Stage IIIB Cutaneous Melanoma AJCC v7; Stage IIIC Cutaneous Melanoma AJCC v7; Stage IV Cutaneous Melanoma AJCC v6 and v7

  11. Recent developments in nanomedicine for melanoma treatment.

    Science.gov (United States)

    Tang, Jian-Qin; Hou, Xiao-Yang; Yang, Chun-Sheng; Li, Ya-Xi; Xin, Yong; Guo, Wen-Wen; Wei, Zhi-Ping; Liu, Yan-Qun; Jiang, Guan

    2017-08-15

    Melanoma is a most aggressive skin cancer with limited therapeutic options and its incidence is increasing rapidly in recent years. The discovery and application of new targeted therapy agents have shown significant benefits. However, adverse side-effects and resistance to chemotherapy remain formidable challenges in the clinical treatment of malignant melanoma. Nanotherapeutics offers an important prospect of overcoming these drawbacks. The anti-tumoral applications of nanomedicine are varied, including those in chemotherapy, RNA interference, photothermal therapy, and photodynamic therapy. Furthermore, nanomedicine allows delivery of the effector structures into the tumor site via passive or active targeting, thereby allowing increased therapeutic specificity and reduced side effects. In this review, we summarize the latest developments in the application of nanocarrier-mediated targeted drug delivery to melanoma and nanomedicine-related clinical trials in melanoma treatment. We also discuss existing problems and opportunities for future developments, providing direction and new thoughts for further studies. © 2017 UICC.

  12. Pembrolizumab for Ipilimumab-Resistant Melanoma

    Science.gov (United States)

    KEYNOTE-002 was designed to test the safety and efficacy of two doses of pembrolizumab compared with chemotherapy in patients with ipilimumab-resistant melanoma; interim results show that pembrolizumab improves progression-free survival for these patients

  13. TCGA study of genetic drivers of melanoma

    Science.gov (United States)

    A comprehensive analysis of the genome of cutaneous melanoma has provided new insights into the roles of frequently mutated cancer genes and other genomic alterations that drive the development of this disease.

  14. Metastatic malignant subungal melanoma: Importance of FNAC

    Directory of Open Access Journals (Sweden)

    Radhika Punshi Nandwani

    2014-01-01

    Full Text Available Subungual melanoma is a rare type of skin cancer. It is an uncommon form of acral lentiginous melanoma. Approximately 85% of cases are misdiagnosed initially, and it is generally associated with a poor prognosis. Herein, we describe a case of metastatic subungal melanoma to the axillary lymph node in a 45-year-old male. Diagnosis of metastasis was made based on cytology, where the clinicians were guided to search for primary. This case report highlights the role of fine-needle aspiration cytology (FNAC in the diagnosis of this entity to draw the attention of the reader to the possible underreporting of melanoma because of a variant that evades diagnosis and our reluctance to think about its existence.

  15. Nivolumab-Based Treatments for Advanced Melanoma

    Science.gov (United States)

    A summary of results from an international, double-blind, randomized phase III trial testing the combination of nivolumab (Opdivo®) and ipilimumab (Yervoy®) against nivolumab alone and ipilimumab alone in patients with advanced melanoma.

  16. Subungual melanoma: Management in the modern era.

    Science.gov (United States)

    Reilly, D J; Aksakal, G; Gilmour, R F; Gyorki, D E; Chauhan, A; Webb, A; Henderson, M A

    2017-12-01

    Subungual melanoma is a rare subtype of cutaneous melanoma that arises from the structures of the nail apparatus. It presents most commonly in older patients and at an advanced stage. A retrospective review of all patients with subungual melanoma in a single institution over a 15-year period was performed. In total, 54 patients were included (26 males, average age 62.9 years), of which 28 cases involved the upper limb. Median tumour thickness was 4.5 mm. Eighteen patients had lymph node metastasis at diagnosis, including 11 of 36 patients with positive sentinel lymph node biopsy. Median survival was 4.6 years. Subungual melanoma has a poor prognosis that is strongly associated with presence of nodal disease at diagnosis. Sentinel lymph node biopsy should be considered to determine stage and prognosis. Copyright © 2017 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

  17. PRE-SERVICE EFL TEACHERS’ SELF-EFFICACY, THEIR ENGLISH PROFICIENCY AND THEIR PREPAREDNESS FOR TEACHING PRACTICUM PROGRAM

    Directory of Open Access Journals (Sweden)

    Himmawan Adi Nugroho

    2017-11-01

    Full Text Available Teacher training institutions hold an important role in preparing their students, the prospective or pre-service teachers, to become professional teachers based on their specific fields of study. This study examined the pre-service EFL teachers’ perception of self-efficacy and their English proficiency toward their preparedness for the teaching practicum program. The study used a survey research design using questionnaire as the instrument to get the pre-service EFL teachers’ perception of self-efficacy. The English proficiency data was from the TEP (test of English proficiency collected from the university’s language center where the pre-service EFL teachers took the test. Findings show that the pre-service EFL teachers have medium to high self-efficacy toward their teaching of EFL. They feel ready in spite of the fact they still have the feeling of anxiety. The courses related with the preparation to become a good and qualified EFL teachers and also for the teaching practicum program helped them to feel more confident.

  18. Experience preferred: insights from our newest public health professionals on how internships/practicums promote career development.

    Science.gov (United States)

    Hernandez, Kristen E; Bejarano, Sandra; Reyes, Francis J; Chavez, Margarita; Mata, Holly

    2014-01-01

    Universities offering undergraduate degrees in health promotion or health education and/or graduate degrees in public health typically require an internship, practicum, or fieldwork experience. This type of mentored experience is an important aspect of career development for the next generation of public health professionals and benefits not only the students but also the profession and the communities in which they work. This article provides perspectives from four public health professionals who have recently graduated from designated minority-serving institutions and highlights the ways in which internship, practicum, or fieldwork experiences have contributed to their career development. From a career development perspective, internships provide unique opportunities to develop professional networks, practice competencies learned in the classroom, gain experience in different environments, and share lessons learned with others in our field. The diversification of the public health research and practice workforce is increasingly recognized as crucial in building health equity. Internship programs that focus specifically on the academic and professional development of students underrepresented in public health provide experiences that meet or supplement academic requirements, and provide students with real-world experience and an expanded network of mentors and role models.

  19. A Case of Melanoma Associated Leukoderma

    Directory of Open Access Journals (Sweden)

    Özer Arıcan

    2010-06-01

    Full Text Available Melanoma associated leukoderma is a rare disease characterized by hypopigmented or depigmented macules, which are usualy localized at distant sites from the primary malignant melonoma. Immunologic response to abnormal melanocytes is thought to be responsible for the physiopathology of the disease. A 34-year- old male patient with a facially localized melanoma associated leukoderma is presented and the clinical features, pathogenesis, differential diagnosis, treatment and follow-up of the disease are discussed with the recent literature.

  20. Genital melanoma: prognosis factors and treatment modality.

    Science.gov (United States)

    Ferraioli, Domenico; Lamblin, Gery; Mathevet, Patrice; Hetu, Jessika; Berakdar, Isabelle; Beurrier, Frederic; Chopin, Nicolas

    2016-11-01

    Genital melanoma is a rare pathology. We present the experience of two comprehensive cancer centers in Lyon (France) in the management of genital melanoma in order to identify prognostic factors and optimal treatments. Between April 1992 and Mars 2014, 16 patients with a primary genital melanoma were referred to our department. Nine patients presented a vaginal melanoma, six vulvar melanomas and only one cervical melanoma. The median dimension of the lesion was 33.7 mm (5-100 mm). The AJCC stage ranged from IB to IIIC. 12 cases were the classic dark-blue flat melanoma and the other 4 cases were an atypical amelanotic tumor. Wide local surgery was performed in nine patients. A radical surgery was performed in six patients. In the large cervical melanoma, radiotherapy was performed as first-line treatment. In all the patients regional lymph node staging was performed. Adjuvant treatment was realized in nine patients. Two patients are alive without recurrence. Only one patient was lost to the first follow-up. The other 13 patients experienced a rapid recurrence. The median disease-free survival and the median overall survival were 11.8 months (2-49 m) and of 30.4 m (11-144 m), respectively. The disease-free survival and overall survival could be linked to a clinical presentation (Breslow thickness and morphology of lesion) associated to the early diagnosis. In our small series, the most important prognosis factor remains the tumor thickness. These rare lesions should be treated in experienced centers in order to improve their prognostic.

  1. Extracutaneous melanomas: a primer for the radiologist

    OpenAIRE

    Keraliya, Abhishek R.; Krajewski, Katherine M.; Braschi-Amirfarzan, Marta; Tirumani, Sree Harsha; Shinagare, Atul B.; Jagannathan, Jyothi P.; Ramaiya, Nikhil H.

    2015-01-01

    Objective: The purpose of this article is to provide a comprehensive review of the imaging features of extracutaneous melanomas. Conclusion: Extracutaneous melanomas are clinically and biologically distinct from their more common cutaneous counterpart with higher frequency of metastatic disease and poorer overall prognosis. Complete surgical excision is the treatment of choice whenever possible; systemic therapy in the form of conventional chemotherapeutic agents as well as novel targeted age...

  2. Vitamin D and melanoma incidence and mortality.

    Science.gov (United States)

    Berwick, Marianne; Erdei, Eszter O

    2013-01-01

    The role of vitamin D (25-OH-D, or 25-hydroxyvitamin D) and its potential confounders in relationship to melanoma risk and mortality is discussed. The paradox that ultraviolet radiation (UVR) exposure is the major environmental risk factor for melanoma etiology as well as a major source of vitamin D might be explained by viewing vitamin D levels as the result of a healthy lifestyle rather than a cause of health. © 2012 John Wiley & Sons A/S.

  3. Peptide-Targeted Radionuclide Therapy for Melanoma

    Science.gov (United States)

    Miao, Yubin; Quinn, Thomas P.

    2011-01-01

    Melanocortin-1 receptor (MC1-R) and melanin are two attractive melanoma-specific targets for peptide-targeted radionuclide therapy for melanoma. Radiolabeled peptides targeting MC1-R/melanin can selectively and specifically target cytotoxic radiation generated from therapeutic radionuclides to melanoma cells for cell killing, while sparing the normal tissues and organs. This review highlights the recent advances of peptide-targeted radionuclide therapy of melanoma targeting MC1R and melanin. The promising therapeutic efficacies of 188Re-(Arg11)CCMSH (188Re-[Cys3,4,10, d-Phe7, Arg11]-α-MSH3-13), 177Lu- and 212Pb-labeled DOTA-Re(Arg11)CCMSH (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-[ReO-(Cys3,4,10, d-Phe7, Arg11)]-α-MSH3-13) and 188Re-HYNIC-4B4 (188Re-hydrazinonicotinamide-Tyr-Glu-Arg-Lys-Phe-Trp-His-Gly-Arg-His) in preclinical melanoma-bearing models demonstrate an optimistic outlook for peptide-targeted radionuclide therapy for melanoma. Peptide-targeted radionuclide therapy for melanoma will likely contribute in an adjuvant setting, once the primary tumor has been surgically removed, to treat metastatic deposits and for treatment of end-stage disease. The lack of effective treatments for metastatic melanoma and end stage disease underscores the necessity to develop and implement new treatment strategies, such as peptide-targeted radionuclide therapy. PMID:18387816

  4. TERT promoter mutations in melanoma survival.

    Science.gov (United States)

    Nagore, Eduardo; Heidenreich, Barbara; Rachakonda, Sívaramakrishna; Garcia-Casado, Zaida; Requena, Celia; Soriano, Virtudes; Frank, Christoph; Traves, Victor; Quecedo, Esther; Sanjuan-Gimenez, Josefa; Hemminki, Kari; Landi, Maria Teresa; Kumar, Rajiv

    2016-07-01

    Despite advances in targeted therapies, the treatment of advanced melanoma remains an exercise in disease management, hence a need for biomarkers for identification of at-risk primary melanoma patients. In this study, we aimed to assess the prognostic value of TERT promoter mutations in primary melanomas. Tumors from 300 patients with stage I/II melanoma were sequenced for TERT promoter and BRAF/NRAS mutations. Cumulative curves were drawn for patients with and without mutations with progression-free and melanoma-specific survival as outcomes. Cox proportional hazard regression models were used to determine the effect of the mutations on survivals. Individually, presence of TERT promoter and BRAF/NRAS mutations associated with poor disease-free and melanoma-specific survival with modification of the effect by the rs2853669 polymorphism within the TERT promoter. Hazard ratio (HR) for simultaneous occurrence of TERT promoter and BRAF/NRAS mutations for disease-free survival was 2.3 (95% CI 1.2-4.4) and for melanoma-specific survival 5.8 (95% CI 1.9-18.3). The effect of the mutations on melanoma-specific survival in noncarriers of variant allele of the polymorphism was significant (HR 4.5, 95% CI 1.4-15.2) but could not be calculated for the carriers due to low number of events. The variant allele per se showed association with increased survival (HR 0.3, 95% CI 0.1-0.9). The data in this study provide preliminary evidence that TERT promoter mutations in combination with BRAF/NRAS mutations can be used to identify patients at risk of aggressive disease and the possibility of refinement of the classification with inclusion of the rs2853669 polymorphism within TERT promoter. © 2016 UICC.

  5. Verrucous-Keratotic Malignant Melanoma (VKMM

    Directory of Open Access Journals (Sweden)

    Nikolay Damianov

    2017-07-01

    Full Text Available We report a patient with a verrucous keratotic variant of melanoma visiting the policlinic of Medical Institute of Ministry of Interior (MVR-Sofia, Department of Dermatology and Dermatologic surgery, with a keratotic verrucous lesion, located on the right thigh, partially deeply pigmented at upper right quadrant. The lesion had appeared three years ago before her presentation in the policlinic, and it had gradually enlarged and become darker in the last twelve months. The surface of the lesion was covered with thick hyperkeratotic lobules. The histologic evaluation revealed verrucous melanoma with a tumour thickness of 3 mm and Clark Level IV and focal ulceration. The tumour was staged as stage IIB (T3bN0M0. Sentinel lymph node biopsy was planned. Verrucous-keratotic forms of malignant melanoma occur more commonly in women and favour the extremities, but may be found on any anatomic site. Seventy-one percent of this melanoma type are situated on the upper and lower extremities. Although two-thirds of these neoplasms can be can be histologically graded according to the classification of Clark, one-third of these melanomas with marked verrucous hyperplasia and hyperkeratosis of the epidermis do not fit into his classification. Histological classification of patients with a verrucous keratotic type of melanoma may sometimes be extremely difficult. The marked papilliferous architecture of these lesions made an assessment of Breslow depth difficult. The presented case highlights the clinical existence and features of such benign-looking melanomas. It is therefore important for surgical pathologists to recognise this unusual variant of malignant melanoma, as it may be confused both clinically and pathologically with benign lesions.

  6. Intratumoral Approaches for the Treatment of Melanoma.

    Science.gov (United States)

    Bommareddy, Praveen K; Silk, Ann W; Kaufman, Howard L

    There have been significant advances in the immunotherapy of melanoma over the last decade. The tumor microenvironment is now known to promote an immune-suppressive milieu that can block effective immune-mediated tumor rejection. Several novel strategies designed to overcome local immunosuppression hold promise for treatment of melanoma and other cancers. These approaches include oncolytic viruses, plasmid DNA delivery, Toll-like receptor agonists, inflammatory dyes, cytokines, checkpoint inhibitors, immunomodulatory agents, and host and pathogenic cell-based vectors. In addition, there are several novel methods for local drug delivery, including direct injection, image-guided, electroporation, and nanodelivery techniques under study. The approval of talimogene laherparepvec (Imlygic), an attenuated, recombinant oncolytic herpesvirus, for melanoma treatment is the first intratumoral agent to receive regulatory approval for the treatment of patients with melanoma. This review will focus on the rationale for intratumoral treatment in melanoma, describe the clinical and safety data for some of the agents in clinical development, and provide a perspective for future clinical investigation with intratumoral approaches. Melanoma has been a paradigm tumor for progress in targeted therapy and immunotherapy and will likely also be the tumor to establish the therapeutic role of intratumoral treatment for cancer.

  7. [Systemic treatment of inoperable metastasized malignant melanoma].

    Science.gov (United States)

    Gutzmer, R; Rauschenberg, R; Meier, F

    2016-07-01

    The medical therapy of inoperable malignant melanoma has changed dramatically over the last few years. The purpose of this article is to summarize the current state of systemic medical treatment of malignant melanoma. Clinical studies and guidelines in the therapy of malignant melanoma are reviewed. Medical therapy of inoperable melanoma changed due to developments in immunotherapies (checkpoint inhibitors) and molecular-targeted therapies (BRAF and MEK inhibitors). Checkpoint inhibitors are antibodies administered as infusions every 2-3 weeks, blocking the checkpoints PD-1 or CTLA-4, thus, preventing downregulation of the immune system. BRAF and MEK inhibitors are small molecules, they are given orally and block a certain signaling pathway in tumor cells. The activation of this pathway has to be demonstrated by molecular analysis of tumor tissue first. This strategy is currently registered for 40-50 % of melanomas harboring a BRAF V600 mutation, while the combination of a BRAF plus MEK inhibitor has been proven more efficient than a BRAF inhibitor alone. A fascinating development has started in the melanoma field due to immunotherapeutic and molecular-targeted treatment strategies. The continuation of this development needs further clinical and translational studies. This includes particular clinical studies with the new substances in the adjuvant situation, and sequences and combinations in the metastatic setting. Translational studies are needed to develop biomarkers for response and side effects.

  8. Cellular heterogeneity in vertical growth phase melanoma.

    Science.gov (United States)

    Laga, Alvaro C; Murphy, George F

    2010-12-01

    Melanoma growing as a tumorigenic nodule is one of the most virulent neoplasms to which the flesh is heir. At a considerably small tumor size, it incurs significant risk for widespread metastatic dissemination. There are no effective means of surgical intervention, chemical therapy, or immunologic therapy for advanced and metastatic melanoma. To review the literature and highlight recent cardinal advances in the understanding of melanoma vertical growth, with specific emphasis on how its recognition and characterization may be applied to diagnostic practice and development of novel investigative approaches. Literature review, archival material, personal experience, and research collaborators. The study of tumorigenic melanoma, both in primary lesions and in metastases, is the key to the eventual eradication of this highly virulent neoplasm that may disseminate widely when only occupying the volume of a grain of rice. Morphology often provides the first insight into structure and function. A growing database using meticulous and inclusive criteria to define tumor stem cells in the context of clinically relevant models now indicates that the key to melanoma heterogeneity may reside in a small subpopulation with the ability to self-renew and form tumors despite most cells present being significantly less virulent. Hopefully, from these insights into melanoma tumor progression from radial growth phase to heterogeneous and tumorigenic vertical growth phase will come additional answers to how smart therapies may be developed that specifically target those vertical growth phase cells that most pertain to patient survival.

  9. Targeting Sphingosine Kinase-1 To Inhibit Melanoma

    Science.gov (United States)

    Madhunapantula, SubbaRao V.; Hengst, Jeremy; Gowda, Raghavendra; Fox, Todd E.; Yun, Jong K; Robertson, Gavin P.

    2012-01-01

    SUMMARY Resistance to therapies develops rapidly for melanoma leading to more aggressive disease. Therefore, agents are needed that specifically inhibit proteins or pathways controlling the development of this disease, which can be combined, dependent on genes deregulated in a particular patient’s tumors. This study shows that elevated sphingosine-1-phosphate (S-1-P) levels resulting from increased activity of sphingosine kinase-1 (SPHK1) occur in advanced melanomas. Targeting SPHK1 using siRNA decreased anchorage dependent and independent growth as well as sensitized melanoma cells to apoptosis inducing agents. Pharmacological SPHK1 inhibitors SKI-I but not SKI-II decreased S-1-P content, elevated ceramide levels, caused a G2-M block and induced apoptotic cell death in melanomas. Targeting SPHK1 using siRNA or the pharmacological agent called SKI-I, decreased the levels of pAKT. Furthermore, SKI-I inhibited the expression of CYCLIN D1 protein and increased the activity of caspase-3/7, which in turn led to the degradation of PARP. In animals, SKI-I but not SKI-II retarded melanoma growth by 25-40%. Thus, targeting SPHK1 using siRNAs or SKI-I has therapeutic potential for melanoma treatment either alone or in combination with other targeted agents. PMID:22236408

  10. Melanoma m (zero): diagnosis and therapy.

    Science.gov (United States)

    Rastrelli, Marco; Alaibac, Mauro; Stramare, Roberto; Chiarion Sileni, Vanna; Montesco, Maria Cristina; Vecchiato, Antonella; Campana, Luca Giovanni; Rossi, Carlo Riccardo

    2013-01-01

    This paper reviews the epidemiology, diagnosis, and treatment of M zero cutaneous melanoma including the most recent developments. This review also examined the main risk factors for melanoma. Tumor thickness measured according to Breslow, mitotic rate, ulceration, and growth phase has the greatest predictive value for survival and metastasis. Wide excision of the primary tumor is the only potentially curative treatment for primary melanoma. The sentinel node biopsy must be performed on all patients who have a primary melanoma with a Breslow thickness > 1 mm, or if the melanoma is from 0,75 mm to 1 mm thick but it is ulcerated and/or the mitotic index is ≥1. Total lymph node dissection consists in removing the residual lymph nodes in patients with positive sentinel node biopsy, or found positive on needle aspiration biopsy, without radiological evidence of spread. Isolated limb perfusion and isolated limb infusion are employed in patients within transit metastases with a rate of complete remission in around 50% and 38% of cases. Electrochemotherapy is mainly indicated for palliation in cases of metastatic disease, though it may sometimes be useful to complete isolated limb perfusion. The only agent found to affect survival as an adjuvant treatment is interferon alpha-2. Adjuvant radiotherapy improves local control of melanoma in patients at a high risk of recurrence after lymph node dissection.

  11. Phytochemicals for the Management of Melanoma.

    Science.gov (United States)

    Pal, Harish Chandra; Hunt, Katherine Marchiony; Diamond, Ariana; Elmets, Craig A; Afaq, Farrukh

    2016-01-01

    Melanoma claims approximately 80% of skin cancer-related deaths. Its life-threatening nature is primarily due to a propensity to metastasize. The prognosis for melanoma patients with distal metastasis is bleak, with median survival of six months even with the latest available treatments. The most commonly mutated oncogenes in melanoma are BRAF and NRAS accounting approximately 60% and 20% of cases, respectively. In malignant melanoma, accumulating evidence suggests that multiple signaling pathways are constitutively activated and play an important role in cell proliferation, cell survival, epithelial to mesenchymal transition, metastasis and resistance to therapeutic regimens. Phytochemicals are gaining considerable attention because of their low toxicity, low cost, and public acceptance as dietary supplements. Cell culture and animals studies have elucidated several cellular and molecular mechanisms by which phytochemicals act in the prevention and treatment of metastatic melanoma. Several promising phytochemicals, such as, fisetin, epigallocatechin-3-gallate, resveratrol, curcumin, proanthocyanidins, silymarin, apigenin, capsaicin, genistein, indole-3-carbinol, and luteolin are gaining considerable attention and found in a variety of fresh fruits, vegetables, roots, and herbs. In this review, we will discuss the preventive potential, therapeutic effects, bioavailability and structure activity relationship of these selected phytochemicals for the management of melanoma.

  12. Treatment and outcomes of anorectal melanoma.

    LENUS (Irish Health Repository)

    Heeney, Anna

    2012-02-01

    INTRODUCTION: anorectal melanoma is an uncommon disease constituting less than 3% of all melanomas. Due to its rarity, there are a lack of randomized control trials regarding appropriate management and current evidence is based mainly on retrospective studies. METHODS: in view of the controversial surgical treatment of anorectal melanoma, we review the most published literature in an attempt to elucidate its typical clinical features along with current thinking with respect to management approaches to this aggressive disease. Using the keywords "anorectal" and "malignant melanoma", a medline search of all articles in English was performed and the relevant articles procured. Additional references were retrieved by cross reference from key articles. RESULTS: anorectal melanoma affects the elderly with a slight preponderance for females. It commonly presents disguised as benign disease with local bleeding or suspicion for haemorrhoidal disease. There is no convincing evidence to indicate that radical resection of primary anorectal melanoma is associated with improvement in local control or survival, and local excision is an acceptable treatment option. CONCLUSION: optimum management depends on several factors and the therapeutic goals should be to lengthen survival and preserve quality-of-life. Given that wide local excision is a more limited intervention with comparable survival it should be considered as the initial treatment choice. Unfortunately prognosis for patients with this disease remains poor despite choice of treatment strategy with overall five year disease-free survival less than twenty percent in most studies.

  13. Anorectal Malignant Melanomas: Experience of Uludag University

    Directory of Open Access Journals (Sweden)

    Berna Aytac

    2010-12-01

    Full Text Available Anorectal melanomas represent a group of mucosal melanomas with unknown etiology and poor prognosis. The lesions can be misdiagnosed as hemorrhoids during clinical examination. We reviewed the morphological and clinical features of 14 anorectal melanomas, and discuss the treatment modalities of this entity. Fourteen patients who were diagnosed with anorectal malignant melanoma between 1997 and 2004 were evaluated with regard to age, sex, size, morphology, lymph node or distant metastasis, treatment modality and survival. Eight patients were female and six were male, and their mean age was 58 years. The size of melanoma ranged from 3 cm to 8 cm. Pathological evaluation revealed epithelioid and spindle cell type tumor in seven and two patients, respectively, whereas, in the remaining seven patients, the tumor was composed of both types. Pigmentation was apparent in all tumors. There was lymph node metastasis in 11 patients and distant metastasis in all patients. Eleven patients underwent abdominoperineal resection and three were treated by local excision. Mean survival was 8.7 months. Prognosis of anorectal melanoma remains poor. Awareness of the diverse clinicopathological features of these lesions, both on the part of the clinicians and pathologists, is crucial for their early detection and proper treatment.

  14. Utilization of Innovations and Techniques of Educational Technology in Delivering of Educational Practicum and Its Impact on Increasing Academic Achievement among Pre-Service Teachers

    Science.gov (United States)

    Ibrahim, Hatim G.

    2017-01-01

    The current study aims to identify the utilization of innovations and techniques of educational technology in teaching of educational practicum and its impact on increasing academic achievement among pre-service teachers. The study sample consisted of (60) pre-service teachers (student teachers) randomly selected from public middle and secondary…

  15. First-Year Practicum Experiences for Preservice Early Childhood Education Teachers Working with Birth-to-3-Year-Olds: An Australasian Experience

    Science.gov (United States)

    White, E. Jayne; Peter, Mira; Sims, Margaret; Rockel, Jean; Kumeroa, Maureen

    2016-01-01

    This article reports on a project, "Collaboration of Universities Pedagogies of Infants' and Toddlers' Development-'down under' (CUPID)," in which the practicum experiences of 1st-year preservice initial teacher education (ITE) students at five universities across Australia and New Zealand (NZ) engaging in early childhood education (ECE)…

  16. What Type of Feedback Do Student Teachers Expect from Their School Mentors during Practicum Experience? The Case of Spanish EFL Student Teachers

    Science.gov (United States)

    Martínez Agudo, Juan de Dios

    2016-01-01

    Mentorship represents a vital component in all teacher education programmes since mentors' feedback plays an essential role in shaping candidate teachers' professional identity. The quality of feedback provided by school mentors during the practicum experience constitutes the main focus of this study. This research paper aimed at investigating…

  17. Towards Collaborative Professional Learning in the First Year Early Childhood Teacher Education Practicum: Issues in Negotiating the Multiple Interests of Stakeholder Feedback

    Science.gov (United States)

    Brown, Alice; Danaher, Patrick

    2008-01-01

    This paper analyses data from two sources of stakeholder feedback--first year pre-service teachers and supervising teachers/centre directors--about the issues involved in creating more collaborative approaches to the first year early childhood teacher education practicum at an Australian regional university. The collection of this feedback was…

  18. Could Practicum Placements in Contrasting Contexts Support the Preparation of Pre-Service Teachers for an Envisaged Inclusive Education System? A South African Study

    Science.gov (United States)

    Rusznyak, Lee; Walton, Elizabeth

    2017-01-01

    In contexts where inclusive education is nascent, teacher educators face the challenge of preparing pre-service teachers for a system that does not yet exist. While this might be possible through university-based coursework, difficulties arise when so few sites that model inclusive pedagogies are available for practicum placements. This article…

  19. Impact of land surface heterogeneity on urban heat island circulation and sea-land breeze circulation in Hong Kong

    Science.gov (United States)

    Wang, Y.; Di Sabatino, S.; Martilli, A.; Li, Y.; Wong, M. S.; Gutiérrez, E.; Chan, P. W.

    2017-04-01

    Hong Kong is one of the most high-rise and highly compact cities in the world. The urban land surface is highly heterogeneous, which creates low-level convergence zones in urban areas, particularly the Kowloon Peninsula. The low-level convergence zone is due to the combined effect of urban heat island circulation (UHIC) and sea-land breeze circulation (SLBC) under weak northeasterly synoptic flow. To study the impacts of anthropogenic fluxes and built-up areas on the local circulation, the Weather Research and Forecasting (WRF) mesoscale model is combined with the multilayer urban canopy building effect parameterization/building energy model (BEP/BEM) parameterization to produce a 3 day simulation of an air pollution episode in Hong Kong in September 2012. To better represent the city land surface features, building information is assimilated in the central part of the Kowloon Peninsula. The WRF-BEP-BEM model captures the 2 m temperature distribution and local wind rotation reasonably well but overestimates the 10 m wind speed with a mean bias error of 0.70 m/s. A dome-shaped feature with a high level of moisture is captured in the convergence zones due to intensified UHIC and inflowing SLBC. The anthropogenic heat increases the air temperature by around 0.3°C up to 250 m, which in turn modifies the SLBC. A new drag coefficient based on λP, plan area per unit ground area, is tested. Besides the basic physical characteristics captured by the WRF-BEP-BEM model, the stagnation of wind in the lower level convergence zone is better captured by this approach than by the traditional constant value coefficient.

  20. Thigmotropism of Malignant Melanoma Cells

    Directory of Open Access Journals (Sweden)

    Pascale Quatresooz

    2012-01-01

    Full Text Available During malignant melanoma (MM progression including incipient metastasis, neoplastic cells follow some specific migration paths inside the skin. In particular, they progress along the dermoepidermal basement membrane, the hair follicles, the sweat gland apparatus, nerves, and the near perivascular space. These features evoke the thigmotropism phenomenon defined as a contact-sensing growth of cells. This process is likely connected to modulation in cell tensegrity (control of the cell shape. These specifically located paucicellular aggregates of MM cells do not appear to be involved in the tumorigenic growth phase, but rather they participate in the so-called “accretive” growth model. These MM cell collections are often part of the primary neoplasm, but they may, however, correspond to MM micrometastases and predict further local overt metastasis spread.

  1. Thigmotropism of malignant melanoma cells.

    Science.gov (United States)

    Quatresooz, Pascale; Piérard-Franchimont, Claudine; Noël, Fanchon; Piérard, Gérald E

    2012-01-01

    During malignant melanoma (MM) progression including incipient metastasis, neoplastic cells follow some specific migration paths inside the skin. In particular, they progress along the dermoepidermal basement membrane, the hair follicles, the sweat gland apparatus, nerves, and the near perivascular space. These features evoke the thigmotropism phenomenon defined as a contact-sensing growth of cells. This process is likely connected to modulation in cell tensegrity (control of the cell shape). These specifically located paucicellular aggregates of MM cells do not appear to be involved in the tumorigenic growth phase, but rather they participate in the so-called "accretive" growth model. These MM cell collections are often part of the primary neoplasm, but they may, however, correspond to MM micrometastases and predict further local overt metastasis spread.

  2. Solitary Secondary Malignant Melanoma of Clavicle Two Years after Enuclation for Ocular Melanoma

    Directory of Open Access Journals (Sweden)

    Halil Tozum

    2013-01-01

    Full Text Available Solitary metastasis of uveal melanoma to bone is extremely rare and usually associated with other organ involvement. We present a rare case of an ocular melanoma patient presenting with solitary metastasis to the clavicle two years after enucleation, without any other organ involvement. In this report, we tried to present our treatment strategy for the solitary metastasis of bone.

  3. Naturally occurring melanomas in dogs as models for non-UV pathways of human melanomas.

    Science.gov (United States)

    Gillard, Marc; Cadieu, Edouard; De Brito, Clotilde; Abadie, Jérôme; Vergier, Béatrice; Devauchelle, Patrick; Degorce, Frédérique; Dréano, Stephane; Primot, Aline; Dorso, Laetitia; Lagadic, Marie; Galibert, Francis; Hédan, Benoit; Galibert, Marie-Dominique; André, Catherine

    2014-01-01

    Spontaneously occurring melanomas are frequent in dogs. They appear at the same localizations as in humans, i.e. skin, mucosal sites, nail matrix and eyes. They display variable behaviors: tumors at oral localizations are more frequent and aggressive than at other anatomical sites. Interestingly, dog melanomas are associated with strong breed predispositions and overrepresentation of black-coated dogs. Epidemiological analysis of 2350 affected dogs showed that poodles are at high risk of developing oral melanoma, while schnauzers or Beauce shepherds mostly developped cutaneous melanoma. Clinical and histopathological analyses were performed on a cohort of 153 cases with a 4-yr follow-up. Histopathological characterization showed that most canine tumors are intradermal and homologous to human rare morphological melanomas types - 'nevocytoid type' and 'animal type'-. Tumor cDNA sequencing data, obtained from 95 dogs for six genes, relevant to human melanoma classification, detected somatic mutations in oral melanoma, in NRAS and PTEN genes, at human hotspot sites, but not in BRAF. Altogether, these findings support the relevance of the dog model for comparative oncology of melanomas, especially for the elucidation of non-UV induced pathways. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  4. Hereditary Melanoma: Update on Syndromes and Management - Genetics of familial atypical multiple mole melanoma syndrome

    Science.gov (United States)

    Soura, E.; Eliades, P.; Shannon, K.; Stratigos, A.; Tsao, H.

    2015-01-01

    Malignant melanoma is considered the most lethal skin cancer if not detected and treated at its early stages. About 10% of melanoma patients report a family history of melanoma; however, individuals with features of true hereditary melanoma (i.e. unilateral lineage, multi-generational, multiple primary lesions, and early onset of disease) are in fact quite rare. Although many new loci have been implicated in hereditary melanoma, CDKN2A mutations remain the most common. Familial melanoma in the presence of multiple atypical nevi should raise suspicion for a germline CDKN2A mutation. Such patients have a high risk of developing multiple primary melanomas and internal organ malignancies especially pancreatic cancer; thus, a multidisciplinary approach is necessary in many cases. The value of dermoscopy examination and total body photography performed at regular intervals has been suggested by a number of studies, and should therefore be considered for these patients and their first degree relatives. In addition, genetic counseling with the possibility of testing can be a valuable adjunct for familial melanoma patients. But, this must be performed with care and only by qualified individuals trained in cancer risk analysis. PMID:26892650

  5. Comprehensive histopathological comparison of epidermotropic/dermal metastatic melanoma and primary nodular melanoma.

    Science.gov (United States)

    Skala, Stephanie L; Arps, David P; Zhao, Lili; Cha, Kelly B; Wang, Min; Harms, Paul W; Andea, Aleodor A; Fullen, Douglas R; Chan, May P

    2018-02-01

    Metastatic melanoma involving the epidermis and/or upper dermis may show significant histological overlap with primary cutaneous melanoma, especially the nodular subtype. Proper histopathological classification is crucial to appropriate staging and management, but is often challenging. The aim of this study was to identify helpful histopathological features for differentiating epidermotropic/dermal metastatic melanoma (EDMM) and primary nodular melanoma (PNM). A cohort of EDMMs (n = 74) and PNMs (n = 75) was retrospectively reviewed for various histopathological features, and the data were compared between groups by the use of univariate analysis. Features significantly associated with EDMM included a tumour size of 10 mm, ulceration, epidermal collarettes, a higher mitotic rate, necrosis, multiple phenotypes, significant pleomorphism, and lichenoid inflammation. In multivariate analysis, a logistic regression model including large tumour size, ulceration, prominent TIPs, lichenoid inflammation and epidermal collarettes was highly predictive of PNM. Six (8%) EDMMs from three patients showed an 'epidermal-only' or 'epidermal-predominant' pattern closely simulating in-situ or microinvasive melanoma. Two of these cases were tested by fluorescence in-situ hybridisation, which confirmed clonal relationships with their corresponding primary melanomas. This is the first comprehensive histopathological comparison of EDMM and PNM. Recognition of the above histopathological associations should aid in the correct classification and staging of cutaneous melanoma. Epidermotropic metastatic melanomas may occasionally show an epidermal-only/epidermal-predominant pattern; accurate diagnosis requires prudent clinical correlation and, when necessary, ancillary molecular tests. © 2017 John Wiley & Sons Ltd.

  6. Fear of new or recurrent melanoma after treatment for localised melanoma.

    Science.gov (United States)

    Bell, Katy J L; Mehta, Yachna; Turner, Robin M; Morton, Rachael L; Dieng, Mbathio; Saw, Robyn; Guitera, Pascale; McCaffery, Kirsten; Low, Donald; Low, Cynthia; Jenkins, Marisa; Irwig, Les; Webster, Angela C

    2017-11-01

    To estimate the amount of fear of new or recurrent melanoma among people treated for localised melanoma in an Australian specialist centre. We randomly selected 400 potential participants from all those treated for localised melanoma at the Melanoma Institute Australia during 2014 (n = 902). They were asked to complete an adapted version of the Fear of Cancer Recurrence Inventory (FCRI). We calculated summary statistics for demographics, clinical variables and total FCRI and subscale scores. Two hundred fifteen people (54%) completed the FCRI questionnaire. The overall mean severity subscale score was 15.0 (95% CI 14.0-16.1). A high proportion of participants had scores above a proposed threshold to screen for clinical fear of cancer recurrence (77% and 63% of participants with and without new or recurrent melanoma had severity subscale scores ≥13). Most participants also had scores above a threshold found to have high specificity for clinical fear of cancer recurrence (65% and 48% of participants with and without new or recurrent melanoma had severity subscale scores ≥16). The severity subscale appeared to discriminate well between groups with differing levels of risk of new or recurrent melanoma. There is a substantial amount of fear of new or recurrent melanoma among this population, despite most having a very good prognosis. Copyright © 2017 John Wiley & Sons, Ltd.

  7. Melanoma

    Science.gov (United States)

    ... Registration General information Housing & travel Education Exhibit hall Mobile app 2019 Annual Meeting Derm Exam Prep Course ... SkinPAC State societies Scope of practice Truth in advertising NP/PA laws Action center Public and patients ...

  8. Identification and interpretation of representative ozone distributions in association with the sea breeze from different synoptic winds over the coastal urban area in Korea.

    Science.gov (United States)

    Hwang, Mi-Kyoung; Kim, Yoo-Keun; Oh, In-Bo; Lee, Hwa Woon; Kim, Cheol-Hee

    2007-12-01

    To aid the studies of long-term impact assessment of cumulative ozone (O3) exposures, the representative 8-hr O3 pollution patterns have been identified over the Greater Seoul Area (GSA) in Korea. Principal component analysis and two-stage clustering techniques were used to identify the representative O3 patterns, and numerical and observational analyses were also used to interpret the identified horizontal distribution patterns. The results yielded three major O3 distribution patterns, and each of the three patterns was found to have strong correlations with local and synoptic meteorological conditions over the GSA. For example, pattern 1, accounting for 46% of O3 concentration distributions, mostly occurred under relatively weak westerly synoptic winds. The predominant features of this pattern were infrequent high O3 levels but a distinct gradient of O3 concentration from the western coastal area to the eastern inland area that was mainly induced by the local sea breeze. Pattern 2, accounting for 31% of O3 concentration distributions, was found with higher O3 levels in the western coastal area but lower in the eastern inland area. This is due to the modified sea breeze under the relatively stronger easterly opposing synoptic wind, affecting the high O3 occurrence in the western coastal area only. However, pattern 3, accounting for 21% of O3 concentration distributions, showed significantly higher O3 concentrations over the whole GSA mainly due to the retarded and slow-moving sea-breeze front under the weak opposing synoptic flow. Modeling study also indicated that local and synoptic meteorological processes play a major role in determining the high O3 concentration distribution patterns over the GSA.

  9. Interannual Variation of the Summer Rainfall in the Taipei Basin Caused by the Impact of ENSO on the Land-Sea Breeze Activity

    Science.gov (United States)

    Chen, Tsing-Chang; Tsay, Jenq-Dar; Takle, Eugene S.

    2015-04-01

    The Taipei Basin, located in northern Taiwan, is formed by the intersection of the Tanshui River Valley (~30km) and the Keelung River Valley (~60km). Summer is the dry season in northern Taiwan, but the maximum rainfall in the Taipei Basin occurs during the summer. The majority of summer rainfall (75%) in this Basin is produced by afternoon thunderstorms triggered by the sea breeze interactions with the mountains to the south of this Basin. Environmental conditions for the roughly three million people living in the Taipei Basin are greatly affected by the land-sea breeze and afternoon thunderstorm activities. Thus, the water supply, air-land traffic, and pollution for this extremely urbanized basin can be profoundly affected by interannual variations of thunderstorm days and rainfall. A systematic analysis was made of thunderstorm days and rainfall for the past two decades. Opposite the interannual variation of the sea surface temperature (SST) anomalies over the NOAA NINO3 - 4 region, ΔSST (NINO3 - 4), clear interannual variations of these two variables emerge. Occurrence days of afternoon thunderstorm and rainfall amount in the Taipei Basin are double during the cold ΔSST(NINO3 - 4) phase compared to the warm phase. During the latter (former) El Niño-Southern Oscillation (ENSO) phase, the Taipei Basin needs a stronger (weaker) warm/moist monsoon southwesterly flow channeled through the land-sea breeze to trigger thunderstorm activity. In contrast, the convergence of water vapor flux over the southeast/east Asian monsoon region toward Taiwan is enhanced more (less) to maintain rainfall over the Taipei Basin during the cold (warm) ENSO phase.

  10. Melanoma risk perception and prevention behavior among African-Americans: the minority melanoma paradox

    Directory of Open Access Journals (Sweden)

    Goldenberg A

    2015-08-01

    Full Text Available Alina Goldenberg,1 Igor Vujic,2,3 Martina Sanlorenzo,2,4 Susana Ortiz-Urda2 1Department of Internal Medicine/Dermatology, University of California, San Diego, 2Mt Zion Cancer Research Center, University of California San Francisco, San Francisco, CA, USA; 3Department of Dermatology, The Rudolfstiftung Hospital, Academic Teaching Hospital, Medical University Vienna, Vienna, Austria; 4Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy Introduction: Melanoma is the most deadly type of skin cancer with 75% of all skin cancer deaths within the US attributed to it. Risk factors for melanoma include ultraviolet exposure, genetic predisposition, and phenotypic characteristics (eg, fair skin and blond hair. Whites have a 27-fold higher incidence of melanoma than African-Americans (AA, but the 5-year survival is 17.8% lower for AA than Whites. It is reported continuously that AA have more advanced melanomas at diagnosis, and overall lower survival rates. This minority melanoma paradox is not well understood or studied. Objective: To explore further, the possible explanations for the difference in melanoma severity and survival in AA within the US. Methods: Qualitative review of the literature. Results: Lack of minority-targeted public education campaigns, low self-risk perception, low self-skin examinations, intrinsic virulence, vitamin D differences, and physician mistrust may play a role in the melanoma survival disparity among AA. Conclusion: Increases in public awareness of melanoma risk among AA through physician and media-guided education, higher index of suspicion among individuals and physicians, and policy changes can help to improve early detection and close the melanoma disparity gap in the future. Keywords: acral, advanced, African-American, disparity, melanoma, survival

  11. Nail apparatus melanoma: a diagnostic opportunity Melanoma do aparelho ungueal: uma oportunidade diagnóstica

    Directory of Open Access Journals (Sweden)

    Ana Maria Carreño

    2013-04-01

    Full Text Available Malignant Melanoma is a high mortality neoplasm. The involvement of the nail apparatus is rare, with only 2 out of 3 patients seeking medical attention as the result of recent nail melanocytic lesions. This results in late diagnosis and a prognosis worse than cutaneous melanoma. We report a female, presenting with ulcerative lesions with clinical and laboratory features compatible with leishmaniasis. On return after treatment initiation a longitudinal melanonychia was observed on her first right finger. Biopsy of the nail matrix was performed. Histopathology was compatible with melanoma in situ. Longitudinal melanonychia is not a specific sign for melanoma and it is important that the dermatologist should identify the suspect lesions correctly. The incidental diagnosis of nail melanoma in situ in our case significantly impacted the patient's survival.Melanoma Maligno é uma neoplasia de alta mortalidade, sendo raro o acometimento do aparelho ungueal. Apenas 2/3 dos pacientes procuram atendimento médico devido lesão melanocítica ungueal recente, tornando o diagnóstico tardio e com prognóstico pior que do melanoma cutâneo. Descreve-se um caso de paciente sexo feminino, apresentando lesões ulceradas com características clínico-laboratoriais compatíveis com leishmaniose tegumentar americana. No retorno após início do tratamento foi observada melanoníquia longitudinal no primeiro quirodáctilo direito. Realizada biópsia da matriz ungueal com histopatológico compatível com melanoma in situ. Melanoníquia longitudinal não é sinal específico de melanoma. A identificação das lesões suspeitas é importante tarefa dos dermatologistas. O diagnóstico incidental de melanoma ungueal in situ do caso relatado resultou em grande impacto na sobrevida da paciente.

  12. Spatial and Temporal Changes in Air Pollution Along the Gulf Coast Observed During BRACE: A Case Study of the Land-Sea Breeze

    Science.gov (United States)

    Wellman, D.; Luke, W.; Arnold, J.; Watson, T.; Gunter, L.

    2003-12-01

    NOAA's Air Resources Laboratory conducted airborne measurements of trace gases and aerosols in the Bay Region Atmospheric Chemistry Experiment (BRACE) using the NOAA Twin Otter. The Twin Otter flew more than 90 hours in 21 flights in and around the Tampa metropolitan region in May, 2002, at altitudes of 60-3000 m MSL. Flights were conducted over rural and suburban areas, over the centers of Tampa and St. Petersburg, and over Tampa Bay and the Gulf of Mexico. One objective of the aircraft flights was to investigate the role of the sea breeze circulation in determining patterns of nutrient deposition and pollutant loads in the Tampa Bay watershed. Results will be presented from a May 8 flight designed to investigate the effect of the sea breeze recirculation upon Tampa's air quality. The Twin Otter took off at 1425 UTC and after performing a spiral ascent over the Sydney ground site, proceeded to fly north, at 200 feet above mean sea level (MSL) just off the Gulf coast, west of St. Petersburg. Back trajectory analysis suggested the dominance of a northerly rotation in the sea breeze; thus, air sampled over the Gulf passed some hours earlier to the south of the Tampa metropolitan area, in an area largely devoid of major pollution sources, before being advected eastward in the afternoon return flow. Ozone levels in this air mass ranged from 40 to 50 ppbv. Farther north the Twin Otter encountered the advected urban plume from Tampa, displaced to the north by the combination of southeasterly sea breeze flow and westerly return flow, and tracked this plume inland. Ozone levels quickly jumped to 60 ppbv, and increased to as high as 90 ppbv as photochemical processing continued in the advected plume. Nitric acid levels, which approached 4 ppbv in the aged urban air at the coast, dropped rapidly to as low as 1 ppbv inland. A final flight leg to the east of downtown Tampa encountered fresh anthropogenic pollution from the afternoon rush hour; ozone was rapidly produced in the

  13. Meteorological observations of the coastal boundary layer structure by remote measurement methods for determining the impact of meteorological conditions on the breeze circulation

    Science.gov (United States)

    Barantiev, D.

    2010-09-01

    Continuous measurements of the characteristics of atmospheric boundary layer and the characteristics of breeze circulation were initiated at the meteorological observatory of Ahtopol on the Black Sea coast (south-east Bulgaria) under a Bulgarian-Russian collaborative programme. Research observations started in July 2008 and go on. These observations are the start of high resolution atmospheric boundary layer vertical structure climatology at a Bulgarian Black Sea coastal site. Automatic weather station «MK-15» with an acoustic anemometer (mounted at 4,5m height) and Flat Array Sodar without RASS extension «Scintec» were installed on polygon of Ahtopol. A preliminary analysis was made of the experimental data on the thermodynamic structure of the atmospheric boundary layer in the coastal zone. Vertical profiles of wind speed, direction and spatio-temporal sectional were constructed according to the sodar data. Graphs of temporal variations of the direction and modulus of wind velocity, vertical velocity, the standard deviation of the acoustic temperature and time variation of air temperature (at a height of 2m - standard synoptic measurements) were constructed according MK-15. The momentum u* = " - w-'u' and sensible heat H = w'T' surface turbulent fluxes were calculated from MK-15 raw data. Prevailing weather conditions contributing to breeze circulation in the area were investigated. Blurred pressure field of high pressure with warm air mass, clear and (or) the overcast weather was characterized for treatment cases. The average wind speed near the ground was did not exceed 3 m/s, with a ripple rate of up to 4 m/s according to MK-15. The nature of the wind changed direction during the day has been practically the same (i.e., diurnal repeats) in all cases. The breeze front location was also detected based on standard measurements in the surface layer (mean values of temperature at 2 m and wind speed and direction from MK-15). In the zone of the front the wind

  14. Common Moles, Atypical Moles (Dysplastic Nevi), and Risk of Melanoma

    Science.gov (United States)

    ... Melanoma—Patient Version Moles, Dysplastic Nevi, and Melanoma Recognition Tool Skin Cancer (Including Melanoma)—Patient Version What ... government may be owned by the writer, and graphics may be owned by their creator. In such ...

  15. Screening for metastatic malignant melanoma of the uvea revisited

    DEFF Research Database (Denmark)

    Eskelin, Sebastian; Pyrhönen, Seppo; Summanen, Paula

    1999-01-01

    ophthalmology, malignant uveal melanoma, metastasis, liver, screening, ultrasonography, X-ray, lactate dehydrogenase, alkaline phosphatase, aminotransferases......ophthalmology, malignant uveal melanoma, metastasis, liver, screening, ultrasonography, X-ray, lactate dehydrogenase, alkaline phosphatase, aminotransferases...

  16. Role of radiotherapy in melanoma management

    International Nuclear Information System (INIS)

    Strojan, Primoz

    2010-01-01

    In melanoma, radiotherapy has generally been considered as a palliative treatment option indicated only for advanced cases or disseminated disease. In the 70s of the previous century, the technological advances in radiotherapy, linked to rapid development of computer sciences, resulted in restored interest for radiotherapy in melanoma management. Although a fundamental lack of well designed prospective and/or randomized clinical trials critically influenced the integration of radiotherapy into treatment strategies in melanoma, radiotherapy was recently recognized as an indispensable part in the multidisciplinary management of patients with melanoma. Altogether, approximately 23% of melanoma patients should receive at least one course of radiotherapy during the course of the disease. In this review, radiobiological properties of melanoma that govern the decisions for the fractionation patterns used in the treatment of this disease are described. Moreover, the indications for irradiation and the results of pertinent clinical studies from the literature, creating a rationale for the use of radiotherapy in the management of this disease, are reviewed and a brief description of radiotherapy techniques is given. Basic treatment modality in melanoma is surgery. However, whenever surgery is not radical or there are adverse prognostic factors identified on histopathological examination of resected tissue specimen, it needs to be supplemented. Also, in patients with unresectable disease or in those not being suitable for major surgery or who refuse proposed surgical intervention, other effective mode(s) of therapy need to be implemented. From this perspective, supported by clinical experiences and literature results, radiotherapy is a valuable option: it is effective and safe, in curative and palliative setting

  17. Melanoma Exosomes Enable Tumor Tolerance in Lymph Nodes

    OpenAIRE

    Hood, Joshua L.

    2016-01-01

    Melanoma preferentially spreads via lymph nodes. Melanoma exosomes can induce angiogenesis and immune suppression. However, a role for melanoma exosomes in facilitating tumor tolerance in lymph nodes has not been considered. Herein, the hypothesis that melanoma exosome mediated induction of vascular endothelial cell (VEC) derived TNF-α results in lymphatic endothelial cell (LEC) mediated tumor tolerance is explored. To support this hypothesis, experiments involving ex vivo lymph node associat...

  18. Long-term Survival after Metastatic Childhood Melanoma

    DEFF Research Database (Denmark)

    Larsen, Anne Kristine; Bybjerg Jensen, Mette; Krag, Christen

    2014-01-01

    SUMMARY: Malignant melanoma in children is very rare and accounts for only 1-3% of all melanomas. A congenital melanocytic nevus depending on the size of the lesion is one of the risk factors for developing childhood melanoma because of the possible malignant transformation. Childhood malignant m...... survived 26 years without recurrence, thus representing an uplifting case of long-term survival of childhood melanoma....

  19. A new understanding in the epidemiology of melanoma

    OpenAIRE

    Erdei, Esther; Torres, Salina M

    2010-01-01

    The incidence of melanoma is continuing to increase worldwide. UV exposure is a known risk factor for melanoma. Geographic location is known to influence UV exposure and the distribution of the incidence of melanoma. Furthermore, epidemiologic data suggest that gender and genetics may influence the distribution of melanoma on the body surface and histopathologic characteristics of the lesion. This article describes what is known about the impact of gender, ethnicity and geography on the progr...

  20. Subretinal lipid exudation associated with untreated choroidal melanoma

    Directory of Open Access Journals (Sweden)

    C K Minija

    2011-01-01

    Full Text Available Subretinal lipid exudation in an untreated choroidal melanoma is very rare. It is seen following plaque radiotherapy in choroidal melanoma. There is only one case report of untreated choroidal melanoma with massive lipid exudation in a patient with metastatic hypernephroma. We report here a rare case of untreated choroidal melanoma with lipid exudation. Subretinal exudation that is rarely seen following plaque brachytherapy was noted at the borders of this untreated tumor. Lipid exudation partially resolved following brachytherapy.

  1. Metastatic Malignant Melanoma Presenting as an Appendiceal Mucocele

    Directory of Open Access Journals (Sweden)

    A. A. Alduaij

    2011-01-01

    Full Text Available Melanoma metastatic to the appendix is extremely rare. Here we describe a case of a 31-year-old female from Bolivia with a remote history of metastatic malignant melanoma first diagnosed as a cutaneous malignant melanoma ten years prior to this presentation. The patient was being followed for a mucocele which on resection was found to be metastatic melanoma. “Mucocele” is a generic diagnosis that warrants further characterization and treatment.

  2. The nursing students' attitude toward using blogs in a nursing clinical practicum in Taiwan: a 3-R framework.

    Science.gov (United States)

    Lin, Kai-Yin; Shen, Yen-Fen

    2013-09-01

    Some nursing educators have been using blogs as a channel to reflect on, share, and discuss questions and ideas for educational purpose. There were not many studies focused on the application of blog technology to the professional development of nursing education in Taiwan. The major goal of this study was to use a blog platform for students, writing their reflection notes, and observing the feedbacks from peers during their clinical practicum. Then we tried to probe the nursing students' attitude toward adopting 3-R categories based blog, which included wRiting reflection notes, Reading peers' notes, and Receiving peers' feedback. Of the 179 fourth grade from one five-year technical college students enrolled in a clinical practice course in Taiwan were used as a pool of sampling. Four-eight students were invited by the researcher to take part in this project. 90% of the participants agreed that blogs provided them with opportunities to share personal experiences with others. 81% of them valued that blogs provided opportunities to offering encouragement and emotional support to their peers. A majority of the participants believed that reading peers' journals was helpful in enhancing their professional development. In addition, all of them agreed that reading peers' journals can help them understand their peer's viewpoints. Most of the participants agreed that they were benefited through receiving feedbacks on the blogs. About 98% of them agreed that feedbacks can promote interaction with peers. The findings of this study generally indicated the participants' positive attitude toward using blogs in their clinical practicum. A majority of the participants also claimed that blogs provided them the opportunities to share personal experiences with their peers as well as to see things from their peers' viewpoints. They believed that reading peers' notes was helpful in enhancing their professional development. In addition, most of them agreed that receiving feedbacks

  3. CASE REPORT Metastatic melanoma to the small bowel ...

    African Journals Online (AJOL)

    lymphoma; however, a high index of suspicion for metastatic melanoma should be maintained if the patient presents with seemingly unrelated symptoms or history of treated melanoma in the past. 1. Casanova F, Lizazo J, Shezi S, Oliver F. Right inguinal bowel fistula on the course of melanoma disease. Internet Journal of ...

  4. Oral Malignant Melanoma in a Ferret ( Mustela putorius furo).

    Science.gov (United States)

    d'Ovidio, Dario; Rossi, Giacomo; Meomartino, Leonardo

    2016-06-01

    Oral malignant melanomas are one of the most common oral malignant neoplasms in dogs but are rare in other domesticated species. This case report describes the clinical manifestations and histological appearance of oral melanoma in a ferret ( Mustela putorius furo). To the authors' knowledge, this is the first published description of a clinical case and histopathological findings of oral melanoma in this species.

  5. Single institution experience of paediatric melanoma in Victoria, Australia.

    Science.gov (United States)

    Le, Quynh; Norris, Diana; McClean, Catriona A; Mcguiness, Myra; Meani, Rowena; Kelly, John W; Pan, Yan

    2017-05-01

    Paediatric melanoma is an uncommon presentation of melanoma that accounts for 3% of all paediatric cancers. The objective was to describe a series of paediatric melanoma cases presenting to a state-wide tertiary referral service over the past 19 years. A search of the Victorian Melanoma Service database was performed to identify all patients under the age of 20 years diagnosed with melanoma from 1994 to 2013. Histological, demographic and phenotypical information for each patient was collected. Patients were matched against the Victorian Death Registry to identify those who had died. Fisher's exact test was used to examine associations. Melanoma-specific survival was estimated using the Kaplan-Meier method. A total of 65 paediatric melanoma patients were included for analysis, in whom 72.3% of melanomas were diagnosed when they were 16-19 years of age with a mean age at diagnosis of 16 years. The mean Breslow thickness was 1.4 mm. It was greatest (3.4 mm) in the youngest age group (melanoma-specific survival rate was 96.8%. This is the first descriptive epidemiological study of paediatric melanoma in Victoria. Further large, population-based, multi-institutional studies of paediatric melanoma are warranted to provide a clearer understanding of this group of melanoma patients. © 2016 The Australasian College of Dermatologists.

  6. Acral lentiginous melanoma in a pregnant African albino, atypical ...

    African Journals Online (AJOL)

    melanocytes). Acral lentiginous melanoma (ALM) is a kind of lentiginous skin melanoma. It is commonly observed on the palms, soles, under the nails and in mucous membranes. Unlike other forms of melanoma, ALM does not appear to be linked ...

  7. Cytotoxic T lymphocyte responses against melanocytes and melanoma

    Directory of Open Access Journals (Sweden)

    Schwartz Erich J

    2011-07-01

    Full Text Available Abstract Background Vitiligo is a common toxicity associated with immunotherapy for melanoma. Cytotoxic T lymphocytes (CTLs against melanoma commonly target melanoma-associated antigens (MAAs which are also expressed by melanocytes. To uncouple vitiligo from melanoma destruction, it is important to understand if CTLs can respond against melanoma and melanocytes at different levels. Methods To understand the dichotomous role of MAA-specific CTL, we characterized the functional reactivities of established CTL clones directed to MAAs against melanoma and melanocyte cell lines. Results CTL clones generated from melanoma patients were capable of eliciting MHC-restricted, MAA-specific lysis against melanocyte cell lines as well as melanoma cells. Among the tested HLA-A*0201-restricted CTL clones, melanocytes evoked equal to slightly higher degranulation and cytolytic responses as compared to melanoma cells. Moreover, MAA-specific T cells from vaccinated patients responded directly ex vivo to melanoma and melanocytes. Melanoma cells express slightly higher levels of MART-1 and gp100 than melanocytes as measured by quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR and immunohistochemistry. Conclusions Our data suggest that CTLs respond to melanoma and melanocytes equally in vitro and directly ex vivo.

  8. Immunotherapy of metastatic melanoma by reversal of immune suppression

    Energy Technology Data Exchange (ETDEWEB)

    Biggs, M.W.; Eiselein, J.E.

    1997-01-01

    Beginning with the observation that the human enteorvirus, Poliovirus Sabin 1, will lyse human melanoma cells in culture, clinical trials involving two patients with advance melanoma were performed. Parenteral injection of the viable Poliovirus into cutaneous melanoma metastases followed in 24 hours by oral administration of cyclophosphamide. The results of these two trials are described.

  9. MicroRNA Expression Profile in Conjunctival Melanoma

    DEFF Research Database (Denmark)

    Larsen, Ann-Cathrine; Mikkelsen, Lauge H.; Borup, Rehannah

    2016-01-01

    Purpose: Conjunctival melanoma (CM) is a rare disease associated with considerable mortality. As opposed to cutaneous melanoma, the epigenetic mechanisms involved in the development of CM and other mucosal melanomas (MMs) are unclear. The purpose of this study was to identify tumor-specific and p...

  10. Using teacher-generated tags of classroom situations to elicit mentor and pre-service teachers' practical knowledge : Title Part of the symposium 'International Perspectives on Mentoring in Practicum Settings'

    NARCIS (Netherlands)

    Dr. F.J.A.J. Crasborn; MA Niek van den Bogert; Dr. Jan van Bruggen

    2011-01-01

    In this AERA Division K symposium, 18 researchers from 7 different countries (China, New Zealand, France, Australia, Netherlands, Spain, and Canada) are brought together. The symposium provides the opportunity to engage and interact with international research efforts focussing on 'practicum

  11. Macroscopic spectral imaging and gene expression analysis of the early stages of melanoma.

    OpenAIRE

    Yang, P.; Farkas, D. L.; Kirkwood, J. M.; Abernethy, J. L.; Edington, H. D.; Becker, D.

    1999-01-01

    BACKGROUND: The stages of melanocytic progression are defined as atypical (dysplastic) nevus, melanoma in situ, melanoma in the radial growth phase (RGP), melanoma in the vertical growth phase (VGP), and melanoma in the metastatic growth phase (MGP). Melanoma in situ and RGP melanoma often develop in contiguous association with atypical nevi. This frequently poses a problem with respect to their early detection. Furthermore, unlike cells obtained from VGP and MGP melanomas, cells derived from...

  12. Antioxidants can increase melanoma metastasis in mice.

    Science.gov (United States)

    Le Gal, Kristell; Ibrahim, Mohamed X; Wiel, Clotilde; Sayin, Volkan I; Akula, Murali K; Karlsson, Christin; Dalin, Martin G; Akyürek, Levent M; Lindahl, Per; Nilsson, Jonas; Bergo, Martin O

    2015-10-07

    Antioxidants in the diet and supplements are widely used to protect against cancer, but clinical trials with antioxidants do not support this concept. Some trials show that antioxidants actually increase cancer risk and a study in mice showed that antioxidants accelerate the progression of primary lung tumors. However, little is known about the impact of antioxidant supplementation on the progression of other types of cancer, including malignant melanoma. We show that administration of N-acetylcysteine (NAC) increases lymph node metastases in an endogenous mouse model of malignant melanoma but has no impact on the number and size of primary tumors. Similarly, NAC and the soluble vitamin E analog Trolox markedly increased the migration and invasive properties of human malignant melanoma cells but did not affect their proliferation. Both antioxidants increased the ratio between reduced and oxidized glutathione in melanoma cells and in lymph node metastases, and the increased migration depended on new glutathione synthesis. Furthermore, both NAC and Trolox increased the activation of the small guanosine triphosphatase (GTPase) RHOA, and blocking downstream RHOA signaling abolished antioxidant-induced migration. These results demonstrate that antioxidants and the glutathione system play a previously unappreciated role in malignant melanoma progression. Copyright © 2015, American Association for the Advancement of Science.

  13. Selenium for the Prevention of Cutaneous Melanoma

    Directory of Open Access Journals (Sweden)

    Douglas Grossman

    2013-03-01

    Full Text Available The role of selenium (Se supplementation in cancer prevention is controversial; effects often depend on the nutritional status of the subject and on the chemical form in which Se is provided. We used a combination of in vitro and in vivo models to study two unique therapeutic windows for intervention in the process of cutaneous melanomagenisis, and to examine the utility of two different chemical forms of Se for prevention and treatment of melanoma. We studied the effects of Se in vitro on UV-induced oxidative stress in melanocytes, and on apoptosis and cell cycle progression in melanoma cells. In vivo, we used the HGF transgenic mouse model of UV-induced melanoma to demonstrate that topical treatment with l-selenomethionine results in a significant delay in the time required for UV-induced melanoma development, but also increases the rate of growth of those tumors once they appear. In a second mouse model, we found that oral administration of high dose methylseleninic acid significantly decreases the size of human melanoma xenografts. Our findings suggest that modestly elevation of selenium levels in the skin might risk acceleration of growth of incipient tumors. Additionally, certain Se compounds administered at very high doses could have utility for the treatment of fully-malignant tumors or prevention of recurrence.

  14. Vemurafenib for the treatment of melanoma.

    LENUS (Irish Health Repository)

    Jordan, Emmet John

    2012-12-01

    Metastatic melanoma is an aggressive disease resistant to chemotherapy. Recent clinical trials have reported improved survival for two novel agents; ipilimumab, a humanized, IgG1 monoclonal antibody that blocks cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and vemurafenib , a BRAF (v-raf murine sarcoma viral oncogene homolog B1) inhibitor targeting an activating mutation in the serine-threonine-protein kinase BRAF gene. AREAS COVERED: The authors reviewed preclinical and clinical data examining the safety of vemurafenib in melanoma. MEDLINE and EMBASE were searched using the medical subject heading \\'vemurafenib\\' and the following text terms: melanoma, BRAF inhibition, vemurafenib. This review provides the reader with an overview of current data examining the efficacy and safety of vemurafenib in metastatic melanoma. EXPERT OPINION: Vemurafenib is an oral agent licensed for patients with BRAF V600E mutation-positive inoperable and metastatic melanoma. The most common adverse effects observed in Phase III clinical trials were dermatological events, arthralgia and fatigue. Specific dermatological toxicities included development of cutaneous squamous cell cancers and keratoacanthomas. Prolongation of the QT interval was also reported. Regular dermatological assessments and electrocardiograms are recommended. Ongoing trials are examining vemurafenib in both the adjuvant setting and metastatic setting in combination with ipilimumab and MEK inhibitors (mitogen-activated protein kinase\\/extracellular signal-regulated kinase). Understanding and overcoming mechanisms of resistance to BRAF inhibitors is the focus of ongoing research.

  15. [Novel Adjuvant Therapy for Ocular Melanoma].

    Science.gov (United States)

    Bosch, Jacobus J; Heindl, Ludwig M

    2017-05-01

    Background Malignant melanoma is the most common cancer of the eye in adults that originates either in the intra-ocular uveal tract or extra-ocular conjunctiva. Although the primary tumor can be treated successfully, no effective therapy for both metastatic conjunctival and uveal melanoma currently exits. Tumor-associated lymphangiogenesis and immune cell infiltration play a pivotal role in the development and therapeutic targeting of metastases. Project description Here, we provide an overview of current translational research on lymphangiogenesis and its therapeutic inhibition as well as modulation of immune cell infiltration by passive and active immunotherapy in melanoma of the eye. Specifically, our previous and ongoing work on lymphangiogenesis and immune cells in ocular melanoma within the clinical research unit FOR 2240 "(Lymph)Angiogenesis and Cellular Immunity in Inflammatory Diseases of the Eye" is summarized. Conclusions Translational research on the modulation of tumor-associated lymphangiogenesis and immune cell infiltration could provide novel targets for adjuvant therapy in melanoma of the eye. Georg Thieme Verlag KG Stuttgart · New York.

  16. Metastatic amelanotic nodular melanoma during pregnancy.

    Science.gov (United States)

    Jasaitiene, Daiva; Valiukeviciene, Skaidra; Makstiene, Jurgita; Juodzbaliene, Edita Brone

    2008-01-01

    This case report presents a very aggressive course of amelanotic nodular melanoma during pregnancy resulting in death five months after delivery. A 34 year-old Caucasian woman at 19th week of the second pregnancy was diagnosed having amelanotic nodular melanoma (tumor thickness - 2.5 mm) with metastases to the regional right inguinal lymph node. Amelanotic nodular melanoma represents malignant melanocytic tumor of the skin, which clinically mimics a variety of benign and malignant skin conditions and therefore commonly leads to delayed diagnosis. Though primary tumor was excised immediately, other treatment procedures as radical lymphadenectomy and chemotherapy were delayed, and immunotherapy was not given totally. At the 29th week of pregnancy, the woman via naturalem delivered a healthy female child, and the chemotherapy was started. Since pregnancy limits the prescription of immunotherapy and chemotherapy, the prognosis for melanoma during pregnancy detected later than in the second stage is poor and can be illustrated by our reported case. Such patients seems to be at higher risk to develop metastasis of melanoma in the internal organs and occasionally even in the fetus; therefore, they should be timely informed about that.

  17. Melanomas of the vulva and vagina.

    Science.gov (United States)

    Skovsted, Sasia; Nielsen, Karsten; Blaakær, Jan

    2017-03-01

    Malignant melanoma is a rare type of cancer in the vagina and vulva associated with a poor prognosis due to late diagnosis and early dissemination. Only a limited amount of literature exists on the condition. This study elucidates the effect of current treatment. All patients diagnosed with malignant melanoma in the vagina or vulva at Aarhus University Hospital, Skejby, Denmark, in the period from 1996 to 2013 were included. Data were collected from the electronic patient records and from the Danish Pathology Register. A total of 17 patients were included. The average age at the time of diagnosis was 77 years and the median overall survival time was 21.9 months. The five-year survival in this study was 17.7%. The majority of the melanomas were nodular and all of the superficially spreading melanomas were found in the vulva only. Malignant melanoma in the vagina has a poorer prognosis than in the vulva as it is diagnosed later. Early diagnosis and staging of this cancer is important. Positron emission tomography-computed tom-ography should be the standard method for staging the disease. Older women with vaginal discharge should always have a gynaecological examination. The primary treatment is resection of the tumour, but future treatment might be a combination of resection and immunotherapy. none. not relevant.  .

  18. [Molecular and immunohistochemical diagnostics in melanoma].

    Science.gov (United States)

    Schilling, B; Griewank, K G

    2016-07-01

    To provide appropriate therapy and follow-up to patients with malignant melanoma, proper diagnostics are of critical importance. Targeted therapy of advanced melanoma is based on the molecular genetic analyses of tumor tissue. In addition, sequencing of genes and other genetic approaches can provide insight into the origin of melanocytic tumors and can aid in distinguishing benign from malignant lesions. In this regard, spizoid neoplasms remain a challenging entity. Aside from genetic analyses of tumor tissue, immunohistochemistry remains an essential tool in melanoma diagnostics and TNM classification. With new immunotherapies being approved for advanced melanoma, immunohistochemistry to determine PD-L1 expression has gained clinical interest. While PD-L1 expression is associated with response to PD-1 blockade, a substantial number of patients without PD-L1 expression can still experience tumor remission upon treatment. In this review, current and future developments in melanoma diagnostics with regard to molecular genetics and immunohistochemistry are summarized. The utilization of such analyses in clinical decision making is also discussed.

  19. Cure of malignant melanoma by single thermal neutron capture treatment using melanoma-seeking compounds

    International Nuclear Information System (INIS)

    Mishima, Yutaka; Ichihashi, Masamitsu; Nakanishi, Takafumi

    1985-01-01

    Since not only malignant melanomas but also many kinds of human cancers, for example thyroid cancer and squamous cell carcinoma, synthesize their specific protein, much attention has been paid to the establishment of selective thermal neutron capture treatment of malignant melanoma as a prototype of such cancer cells. This paper presents 10 B chlorpromazine compounds and 10 B 1 -para-boronophenylalanine ( 10 B 1 -BPA) as tumor-seeking 10 B compounds which themselves possess selective affinity for the specific metabolic activity of the target cancer cells. An overview of the following studies on the effects of 10 B 1 -BPA in the thermal neutron capture treatment of melanoma is provided: 1) in vitro studies on specific enhanced melanoma cell killing effects of 10 B 1 -BPA; 2) in vivo studies on therapeutic effects of 10 B 1 -BPA using melanoma-bearing hamsters; and 3) preclinical therapeutic experiments using spontaneously occurring malignant melanoma in Duroc pig skin, including experiments in which melanoma was successfully cured. (Namekawa, K.)

  20. Mesoscale modeling of smoke transport over the Southeast Asian Maritime Continent: Interplay of sea breeze, trade wind, typhoon, and topography

    Science.gov (United States)

    Wang, Jun; Ge, Cui; Yang, Zhifeng; Hyer, Edward J.; Reid, Jeffrey S.; Chew, Boon-Ning; Mahmud, Mastura; Zhang, Yongxin; Zhang, Meigen

    2013-03-01

    The online-coupled Weather Research and Forecasting model with Chemistry (WRFchem) is used to simulate the transport of smoke particles over the Southeast Asian Maritime Continent during September-October 2006. In this period, dry conditions associated with the moderate El Niño event caused the largest regional biomass burning outbreak since 1997. Smoke emission in WRFchem is specified according to the Fire Locating and Modeling of Burning Emissions (FLAMBE) database derived from Moderate Resolution Imaging Spectroradiometer (MODIS) fire products. The modeled smoke transport pathway is found to be consistent with the MODIS true color images and measured mass concentration of surface PM10 (particulate matter with diameter less than 10 μm). The interplay of sea/land breezes, typhoons and storms over the subtropical western Pacific Ocean, trade winds, and topographic effects, can be clearly seen in the model simulation. The most severe smoke events in 1-5 October 2006 are found to be associated with the meteorological responses to the typhoon Xangsane (#18) over the western subtropical Pacific Ocean, which moved smoke from Sumatra eastward in the lower troposphere (below 700 hPa), forming smoke layers mixed with and above the boundary layer clouds over Borneo. In contrast, the second largest week-long smoke transport event of 15-18 October 2006 was associated with the seasonal monsoonal transition period, during which smoke plumes were wide spread over the 5°S-5°N zone as a result of (a) the near surface divergence coupled with the 700 hPa bifurcation of wind (flowing both to the west and to the east), and (b) the near-surface southeasterly and easterly winds along the equator transporting smoke from Borneo to Sumatra and Peninsular Malaysia. Analysis of data from the Cloud-Aerosol Lidar with Orthogonal Polarisation (CALIOP) shows that smoke particles in October 2006 were primarily located within 3.5 km above the surface. Smoke particles contributed roughly half

  1. Gene expression analyses of primary melanomas reveal CTHRC1 as an important player in melanoma progression

    Science.gov (United States)

    Eriksson, Johanna; Le Joncour, Vadim; Nummela, Pirjo; Jahkola, Tiina; Virolainen, Susanna; Laakkonen, Pirjo; Saksela, Olli; Hölttä, Erkki

    2016-01-01

    Melanoma is notorious for its high tendency to metastasize and its refractoriness to conventional treatments after metastasis, and the responses to most targeted therapies are short-lived. A better understanding of the molecular mechanisms behind melanoma development and progression is needed to develop more effective therapies and to identify new markers to predict disease behavior. Here, we compared the gene expression profiles of benign nevi, and non-metastatic and metastatic primary melanomas to identify any common changes in disease progression. We identified several genes associated with inflammation, angiogenesis, and extracellular matrix modification to be upregulated in metastatic melanomas. We selected one of these genes, collagen triple helix repeat containing 1 (CTHRC1), for detailed analysis, and found that CTHRC1 was expressed in both melanoma cells and the associated fibroblasts, as well as in the endothelium of tumor blood vessels. Knockdown of CTHRC1 expression by shRNAs in melanoma cells inhibited their migration in Transwell assays and their invasion in three-dimensional collagen and Matrigel matrices. We also elucidated the possible down-stream effectors of CTHRC1 by gene expression profiling of the CTHRC1-knockdown cells. Our analyses showed that CTHRC1 is regulated coordinately with fibronectin and integrin β3 by the pro-invasive and -angiogenic transcription factor NFATC2. We also found CTHRC1 to be a target of TFGβ and BRAF. These data highlight the importance of tumor stroma in melanoma progression. Furthermore, CTHRC1 was recognized as an important mediator of melanoma cell migration and invasion, providing together with its regulators—NFATC2, TGFβ, and BRAF—attractive therapeutic targets against metastatic melanomas. PMID:26918341

  2. CDKN2A (INK4A-ARF) mutation analysis to distinguish cutaneous melanoma metastasis from a second primary melanoma.

    NARCIS (Netherlands)

    Blokx, W.A.M.; Lesterhuis, W.J.; Andriessen, M.P.M.; Verdijk, M.A.J.; Punt, C.J.A.; Ligtenberg, M.J.L.

    2007-01-01

    The histologic differential diagnosis between a second primary cutaneous melanoma and cutaneous melanoma metastasis in a patient with a previous history of melanoma can be very difficult. This case report describes the first application of CDKN2A mutation analysis for discriminating a cutaneous

  3. CDKN2A (INK4A-ARF) mutation analysis to distinguish cutaneous melanoma metastasis from a second primary melanoma

    NARCIS (Netherlands)

    Blokx, Willeke A. M.; Lesterhuis, W. Joost; Andriessen, Monique P. M.; Verdijk, Marian A. J.; Punt, Cornelis J. A.; Ligtenberg, Marjolijn J. L.

    2007-01-01

    The histologic differential diagnosis between a second primary cutaneous melanoma and cutaneous melanoma metastasis in a patient with a previous history of melanoma can be very difficult. This case report describes the first application of CDKN2A mutation analysis for discriminating a cutaneous

  4. Cerebral metastases from malignant melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, G. (Royal Prince Alfred Hospital, Sydney (Australia). Department of Radiation Oncology Royal Prince Alfred Hospital, Sydney (Australia). Sydney Melanoma Unit); Firth, I. (Royal Prince Alfred Hospital, Sydney (Australia). Department of Medical Oncology); Coates, A. (Royal Prince Alfred Hospital, Sydney (Australia). Department of Radiation Oncology Royal Prince Alfred Hospital, Sydney (Australia). Sydney Melanoma Unit)

    1993-03-01

    A retrospective study was undertaken of factors affecting survival in 129 patients with cerebral metastases from malignant melanoma referred to the Department of Radiation Oncology from June '82-January '90. Their ages ranged from 19-83 years and the time interval form diagnosis of the primary tumour to development of cerebral metastases ranged from 1 month-17 years. Cerebral metastases were apparently solitary in 59 (46%) and multiple in 70 (54%) patients. Craniotomy with resection of tumour was performed in 49 patients, of whom 24 had a solitary cerebral metastasis as the only evidence of disease Most patients (94%) received radiotherapy-course. Median survival of the whole group after detection of cerebral metastases was 5 months (range <1-87+). Univariate analysis indicated that a solitary cerebral metastasis, absence of extracranial disease and tumour resection predicted improved survival, but only surgical intervention was of independent prognostic significance in a multivariate analysis. The effect of cranial irradiation on survival could not be assessed, but the dose of radiation did not influence survival. Of the 10 patients who survived for more than 2 years, 8 had total resection of a solitary cerebral metastasis. (author). 25 refs., 3 figs., 3 tabs.

  5. Detection of desmoplastic melanoma with dermoscopy and reflectance confocal microscopy.

    Science.gov (United States)

    Maher, N G; Solinas, A; Scolyer, R A; Puig, S; Pellacani, G; Guitera, P

    2017-12-01

    Desmoplastic melanoma (DM) is frequently misdiagnosed clinically and often associated with melanoma in situ (MIS). To improve the detection of DM using dermoscopy and reflectance confocal microscopy (RCM). A descriptive analysis of DM dermoscopy features and a case-control study within a melanoma population for RCM feature evaluation was performed blindly, using data obtained between 2005 and 2015. After retrospectively identifying all DM cases with RCM data over the study period (n = 16), a control group of non-DM melanoma patients with RCM data, in a ratio of at least 3 : 1, was selected. The control group was matched by age and primary tumour site location, divided into non-DM invasive melanomas (n = 27) and MIS (n = 27). Invasive melanomas were selected according to the melanoma subtypes associated with the DM cases. The main outcomes were the frequency of melanoma-specific features on dermoscopy for DM; and the odds ratios of RCM features to distinguish DM from MIS and/or other invasive melanomas; or MIS from the combined invasive melanoma group. At least one of the 14 melanoma-specific features evaluated on dermoscopy was found in 100% of DMs (n = 15 DM with dermoscopy). Known RCM melanoma predictors were commonly found in the DMs, such as pagetoid cells (100%) and cell atypia (100%). The RCM feature of spindle cells in the superficial dermis was more common in DM compared with the entire melanoma control group (OR 3.82, 95% CI 1.01-14.90), and particularly compared to MIS (OR 5.48, 95% CI 1.11-32.36). Nucleated cells in the dermis and the RCM correlate of dermal inflammation were also significant RCM features favouring DM over MIS, as well as invasive melanoma over MIS. Dermoscopy and RCM may be useful tools for the identification of DM. Certain RCM features may help distinguish DM from MIS and other invasive melanomas. Larger studies are warranted. © 2017 European Academy of Dermatology and Venereology.

  6. Key points in the dermoscopic diagnosis of hypomelanotic melanoma and nodular melanoma.

    Science.gov (United States)

    Moloney, Fergal J; Menzies, Scott W

    2011-01-01

    Nodular melanoma (NM) and amelanotic/hypomelanotic melanoma (AHM) often present a challenge to the diagnosing clinician. A significant proportion of AHM are nodular in nature. Such tumors may lack features of asymmetry and altered peripheral pigmentation routinely observed in other melanoma subtypes. This lack of distinguishing clinical features can potentially result in delayed diagnosis or inappropriate treatment. This review highlights the key points in evaluating the range of lesions where AHM or NM are considered in the differential diagnosis and summarizes current evidence in relation to pigmented and vascular dermoscopic diagnostic criteria for both. © 2011 Japanese Dermatological Association.

  7. Bioelectric Applications for Treatment of Melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Beebe, Stephen J., E-mail: sbeebe@odu.edu; Schoenbach, Karl H.; Heller, Richard [Frank Reidy Research Center for Bioelectrics/Old Dominion University 4211 Monarch Way, Suite 300, Norfolk, Virginia 23508 (United States)

    2010-09-27

    Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT) or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs). EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in mice. Applications of bioelectrics, using conventional electroporation and extensions of it, provide effective alternative therapies for melanoma.

  8. Bioelectric Applications for Treatment of Melanoma

    International Nuclear Information System (INIS)

    Beebe, Stephen J.; Schoenbach, Karl H.; Heller, Richard

    2010-01-01

    Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT) or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs). EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in mice. Applications of bioelectrics, using conventional electroporation and extensions of it, provide effective alternative therapies for melanoma

  9. Bioelectric Applications for Treatment of Melanoma

    Directory of Open Access Journals (Sweden)

    Richard Heller

    2010-09-01

    Full Text Available Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs. EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in mice. Applications of bioelectrics, using conventional electroporation and extensions of it, provide effective alternative therapies for melanoma.

  10. Cytogenetics of melanoma and nonmelanoma skin cancer.

    Science.gov (United States)

    Carless, Melanie A; Griffiths, Lyn R

    2014-01-01

    Cytogenetic analysis of melanoma and nonmelanoma skin cancers has revealed recurrent aberrations, the frequency of which is reflective of malignant potential. Highly aberrant karyotypes are seen in melanoma, squamous cell carcinoma, actinic keratosis, Merkel cell carcinoma and cutaneous lymphomas with more stable karyotypes seen in basal cell carcinoma, keratoacanthoma, Bowen's disease and dermatofibrosarcoma protuberans. Some aberrations are common among a number of skin cancer types including rearrangements and numerical abnormalities of chromosome 1, -3p, +3q, partial or entire trisomy 6, trisomy 7, +8q, -9p, +9q, partial or entire loss of chromosome 10, -17p, +17q and partial or entire gain of chromosome 20. Combination of cytogenetic analysis with other molecular genetic techniques has enabled the identification of not only aberrant chromosomal regions, but also the genes that contribute to a malignant phenotype. This review provides a comprehensive summary of the pertinent cytogenetic aberrations associated with a variety of melanoma and nonmelanoma skin cancers.

  11. Orbital melanoma with calcification: A diagnostic dilemma

    Directory of Open Access Journals (Sweden)

    Sukhdeep Bains

    2016-01-01

    Full Text Available Primary orbital melanoma is rare and has varied initial presentation. A 28-year-old female presented with proptosis and decreased vision in the left eye. Computed tomography scan showed an orbital mass with contrast enhancement and calcification around the optic nerve leading to a diagnosis of meningioma. The patient chose to be on observation. Loss of vision with an increase in proptosis was seen at 6 months follow-up. On surgical exploration, a well-defined pigmented mass was seen encasing the optic nerve. Histopathological analysis revealed a malignant melanoma. Metastatic workup was negative. Left eye lid sparing exenteration was done. A high index of suspicion is necessary in a rapidly growing suspected optic nerve sheath meningioma and a differential diagnosis including orbital melanoma be considered.

  12. Optic nerve invasion of uveal melanoma

    DEFF Research Database (Denmark)

    Lindegaard, Jens; Isager, Peter; Prause, Jan Ulrik

    2007-01-01

    The aim of the study was to identify the histopathological characteristics associated with the invasion of the optic nerve of uveal melanoma and to evaluate the association between invasion of the optic nerve and survival. In order to achieve this, all uveal melanomas with optic nerve invasion...... in Denmark between 1942 and 2001 were reviewed (n=157). Histopathological characteristics and depth of optic nerve invasion were recorded. The material was compared with a control material from the same period consisting of 85 cases randomly drawn from all choroidal/ciliary body melanomas without optic nerve...... invasion. Prelaminar/laminar optic nerve invasion was in multivariate analysis associated with focal retinal invasion, neovascularization of the chamber angle, and scleral invasion. Postlaminar invasion was further associated with non-spindle cell type and rupture of the inner limiting membrane...

  13. Axillary Silicone Granulomas in Patients With Melanoma.

    Science.gov (United States)

    Fernández Canedo, M I; Blázquez Sánchez, N; Valdés Solís, P; de Troya Martín, M

    2016-05-01

    Subcutaneous lesions may be detected during follow-up of patients with melanoma. The main entities that should be contemplated in the differential diagnosis in such cases are in-transit and regional lymph node metastases. We describe 2 cases of women with breast implants who developed palpable subcutaneous lesions in the axillary region during follow-up of melanoma. In both cases, the ultrasound study showed diffuse hyperechoic signals forming the characteristic snowstorm sign in the subcutaneous tissue. Ultrasound proved to be a key diagnostic tool for ruling out melanoma-related disease, such as in-transit metastases and regional lymph node metastases. Copyright © 2015 Elsevier España, S.L.U. y AEDV. All rights reserved.

  14. Melanoma of the Hand: Current Practice and New Frontiers

    Directory of Open Access Journals (Sweden)

    John Brad Turner

    2014-03-01

    Full Text Available Melanoma of the hand represents a complicated clinical entity. Anatomic features of the hand create challenges in successful management of melanoma not encountered elsewhere in the body. The objectives of this article are to outline current standards for managing melanoma of the hand including diagnosis, surgical, and chemotherapeutic management. Particular emphasis will be placed on currently debated topics of the role of sentinel lymph node biopsy, the role of Mohs micrographic surgery, tissue sparing management of subungual melanoma, and the consideration of melanoma of the hand as a distinct entity based on clinical and molecular studies.

  15. Oral malignant melanoma: A rare case report and review

    Directory of Open Access Journals (Sweden)

    Mangala Rakaraddi

    2011-01-01

    Full Text Available Primary malignant melanoma is only rarely found in oral cavity (estimated between 0.2 and 8-0% of all melanomas and occurs approximately four times more frequently in oral mucosa of the upper jaw, usually on the palate, alveolar gingiva and melanoma of mandibular gingiva is extremely rare. The peak age of diagnosis of melanoma is between 55 and 65 years. A biopsy is required to confirm the diagnosis. Here, we present a rare case of malignant melanoma of mandibular gingiva in a 64-year-old female patient which is confirmed by histopathology.

  16. Current Research and Development of Chemotherapeutic Agents for Melanoma

    Directory of Open Access Journals (Sweden)

    Kyaw Minn Hsan

    2010-04-01

    Full Text Available Cutaneous malignant melanoma is the most lethal form of skin cancer and an increasingly common disease worldwide. It remains one of the most treatment-refractory malignancies. The current treatment options for patients with metastatic melanoma are limited and in most cases non-curative. This review focuses on conventional chemotherapeutic drugs for melanoma treatment, by a single or combinational agent approach, but also summarizes some potential novel phytoagents discovered from dietary vegetables or traditional herbal medicines as alternative options or future medicine for melanoma prevention. We explore the mode of actions of these natural phytoagents against metastatic melanoma.

  17. Stereological estimates of nuclear volume in thin malignant melanomas

    DEFF Research Database (Denmark)

    Björnhagen, V; Månsson-Brahme, E; Lindholm, J

    1998-01-01

    melanomas were individually compared with 33 thin non-metastasizing melanomas after individual matching of cases with one or two randomly chosen controls for site of primary tumour, tumour thickness, level of invasion, tumour regression and follow-up. Conditional logistic regression analysis showed......Stereological estimation of nuclear volume was performed in a case control study of 72 malignant melanomas, thickness melanomas due to too sparse cellularity. Thus, 21 thin metastasizing...... no significant differences in nuclear volume between metastasizing and non-metastasizing thin malignant melanomas....

  18. Circulating tumor cells in melanoma patients.

    Directory of Open Access Journals (Sweden)

    Gary A Clawson

    Full Text Available Circulating tumor cells (CTCs are of recognized importance for diagnosis and prognosis of cancer patients. With melanoma, most studies do not show any clear relationship between CTC levels and stage of disease. Here, CTCs were enriched (∼400X from blood of melanoma patients using a simple centrifugation device (OncoQuick, and 4 melanocyte target RNAs (TYR, MLANA, MITF, and MIF were quantified using QPCR. Approximately one-third of melanoma patients had elevated MIF and MLANA transcripts (p<0.0001 and p<0.001, respectively compared with healthy controls. In contrast, healthy controls had uniformly higher levels of TYR and MITF than melanoma patients (p<0.0001. There was a marked shift of leukocytes into the CTC-enriched fractions (a 430% increase in RNA recovery, p<0.001, and no relationship between CTC levels and stage of disease was found. CTCs were captured on microfabricated filters and cultured. Captured melanoma CTCs were large cells, and consisted of 2 subpopulations, based on immunoreactivity. One subpopulation (∼50% stained for both pan-cytokeratin (KRT markers and the common leukocyte marker CD-45, whereas the second subpopulation stained for only KRT. Since similar cells are described in many cancers, we also examined blood from colorectal and pancreatic cancer patients. We observed analogous results, with most captured CTCs staining for both CD-45/KRT markers (and for the monocyte differentiation marker CD-14. Our results suggest that immature melanocyte-related cells (expressing TYR and MITF RNA may circulate in healthy controls, although they are not readily detectable without considerable enrichment. Further, as early-stage melanomas develop, immature melanocyte migration into the blood is somehow curtailed, whereas a significant proportion of patients develop elevated CTC levels (based on MIF and MLANA RNAs. The nature of the captured CTCs is consistent with literature describing leukocyte/macrophage-tumor cell fusion hybrids

  19. Melanoma biomolecules: independently identified but functionally intertwined

    Directory of Open Access Journals (Sweden)

    Danielle Erin Dye

    2013-09-01

    Full Text Available The majority of patients diagnosed with melanoma present with thin lesions and generally these patients have a good prognosis. However, 5% of patients with early melanoma (< 1mm thick will have recurrence and die within 10 years, despite no evidence of local or metastatic spread at the time of diagnosis. Thus, there is a need for additional prognostic markers to help identify those patients that may be at risk of recurrent disease. Many studies and several meta-analyses have compared gene and protein expression in melanocytes, naevi, primary and metastatic melanoma in an attempt to find informative prognostic markers for these patients. However, although a large number of putative biomarkers have been described, few of these molecules are informative when used in isolation. The best approach is likely to involve a combination of molecules. We believe one approach could be to analyze the expression of a group of interacting proteins that regulate different aspects of the metastatic pathway. This is because a primary lesion expressing proteins involved in multiple stages of metastasis may be more likely to lead to secondary disease than one that does not. This review focuses on five putative biomarkers - melanoma cell adhesion molecule (MCAM, galectin-3 (gal-3, matrix metalloproteinase 2 (MMP-2, chondroitin sulfate proteoglycan 4 (CSPG4 and paired box 3 (PAX3. The goal is to provide context around what is known about the contribution of these biomarkers to melanoma biology and metastasis. Although each of these molecules have been independently identified as likely biomarkers, it is clear from our analyses that each are closely linked with each other, with intertwined roles in melanoma biology.

  20. Metastatic melanoma and vemurafenib: novel approaches

    Directory of Open Access Journals (Sweden)

    Ramon Andrade De Mello

    2012-04-01

    Full Text Available Metastatic melanoma (MM presents a treatment challenge to oncologists worldwide. Dacarbazine is the first line chemotherapy treatment for MM, though the overall response rates are very poor. Recently, the v-raf murine sarcoma viral oncogene homolog B1 (BRAF V600 mutation was found to play a main role in MM. This mutation is present in 40-60% of melanoma patients. Vemurafenib is a BRAF kinase inhibitor that showed impressive results in phase I-III trials and was thus recently approved for the treatment of MM. This paper will briefly focus on vemurafenib in the treatment of MM and highlight concerns.