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Sample records for melanoma humano papel

  1. Resistance to the ionizing radiation in cells of human melanoma. Role of the antioxidant enzymes and of the free radicals of the oxygen; Resistencia a la radiacion ionizante en celulas de melanoma humano. Papel de las enzimas antioxidantes y de los radicales libres del oxigeno

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    Medina, V.; Cricco, G.; Massari, N.; Nunez, M.; Martin, G.; Mohanad, N.; Gutierrez, A.; Bergoc, R.; Rivera, E. [Laboratorio de Radioisotopos, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, Buenos Aires (Argentina); Crescenti, E.; Croci, M. [Instituto de Inmunooncologia, Cordoba 3200, Buenos Aires (Argentina)]. e-mail: vmedina@ffyb.uba.ar

    2006-07-01

    The malignant melanoma is a highly aggressive and potentially lethal type of skin cancer. Previously we have reported that the cellular human lines of melanoma WM35 and M15 are resistant to the ionizing radiation (IR). The histamine (HA) although it has a regulator effect of the cellular proliferation in these lines, it is not capable of to modify the response to the IR like it makes with other malignant cellular lines. To investigate the bases of the radioresistance of the melanoma lines we have studied in the WM35 the production of free radicals of oxygen (ROS), the activity of the antioxidant enzymes and their modifications by action of the IR and of the HA. In studies in vitro the cells were treated with HA 10 {mu}M from 20 hs before being irradiated with a dose of 2 Gy (source {sup 137}Cs, dose rate 7.7 Gy/min). The ROS levels, superoxide anion (O{sub 2}{sup -}) and hydrogen peroxide (H{sub 2}O{sub 2}) its were measured by flow cytometry using fluorescent coloring and the activity of dismutase superoxide (SOD), Catalase (CAT) and Glutathion Peroxidase (GPx) its were determined by spectrophotometric techniques and the protein levels by Western blot. The results indicate that in the cells WM35 the HA increases the production of H{sub 2}O{sub 2} in 96% and it diminishes lightly (17%) the levels of O{sub 2}{sup -} . On the contrary, the IR diminishes the levels of H{sub 2}O-2 in 47% and it increases in 46% those of O{sub 2}{sup -}. In the irradiated cells the HA power the decrease of H{sub 2}O{sub 2} produced by the IR. The variation of the enzymes activity is coincident with these changes in the levels of ROS: the treatment with HA increases the activity of SOD and it diminishes that of CAT in cells without irradiating; on the other hand, in the irradiated cells the HA it diminishes the SOD significantly. On the base of these results we can conclude that the levels of H{sub 2}O{sub 2} are directly related with the sensitivity of the cells WM35 to the IR. The HA

  2. Papel de los archivos fotográficos de Derechos Humanos en la memoria colectiva

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    Sonia Natalia Cogollo-Ospina

    2016-01-01

    Full Text Available Se hace una revisión de investigaciones y documentos centrados en la relación establecida entre fotografía y memoria colectiva a través de los archivos fotográficos de Derechos Humanos, así como la función que cumplen los museos, centros de documentación o lugares donde se encuentran ubicados. Para la selección del material se atendió a su disponibilidad principalmente en bases de datos indexadas de reconocido prestigio: Web of Science, Scielo, EbscoHost, DOAJ y Dialnet, con descriptores como fotografía y memoria, archivo fotográfico, memoria colectiva y museos, con un corte temporal de 2006-2015. Se organiza el material en función de una serie de preguntas decisivas a la hora de abordar los problemas atinentes a la conservación de un archivo fotográfico y su papel en la memoria colectiva de poblaciones vulnerables. Los lugares de memoria reflejan una tensión entre los intereses políticos y la necesidad de las poblaciones vulnerables de manifestarse y dejar testimonio de las infracciones a los derechos humanos. La organización del material fotográfico plantea serias dificultades respecto a la conservación y clasificación con la cantidad de imágenes digitales que hoy se producen. It is made a review of researchs and documents focused in the relation between photography and collective memory trough photoarchives of human rights, and the function that have the museums, documentation centers or memory places where they are. For the material’s selection it was attended to their availability in indexed databases with prestige: Web of Science, Scielo, EbscoHost, DOAJ, and Dialnet, with descriptors as photograph and memory, photoarchive, collective memory and museums, and papers between 2006 and 2015. The material is organized in function of a series of questions about the conservation of a photoarchive and its role in collective memory of vulnerable population. The memory places reflects a tension between political interests and

  3. VIRUS DEL PAPILOMA HUMANO REACCIONES ADVERSAS DE LOS MEDICAMENTOS Y EL PAPEL DE LOS MEDIOS MASIVOS DE COMUNICACIÓN.

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    Martalucía Tamayo Fernández

    2014-10-01

    Full Text Available A raíz del reciente fenómeno sucedido en Carmen de Bolívar, mucho se ha especulado sobre lo que allí pueda estar pasando y se ha puesto sobre el tapete un tema tan delicado e importante para la salud pública de nuestro país, como es el uso masivo de vacunas y más aún, de la vacuna del papiloma humano (VPH. Estos hechos y las noticias ciertas o verdaderas que la prensa y la televisión han mostrado, nos llevan a preguntarnos una vez más por la responsabilidad y el papel de los medios masivos de comunicación en estas situaciones de reacciones adversas a medicamentos o a biológicos. Este artículo analiza los aspectos históricos de la noticia, su impacto en la persona que la recibe, la ética del periodismo y la inconveniencia de la presión sobre el comunicador, quien debe responder por el impacto que genere entre la gente que sigue a un determinado medio, lo que influye en sus ganancias.

  4. La comunicación como un derecho humano y su papel en la longevidad

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    Beltrina Côrte

    2011-12-01

    Full Text Available La prolongación de la vida y los cambios que se producen en el proceso de envejecimiento nos advierten acerca de la falta de información sobre la vejez, las consecuencias del avance de la ciencia y el impacto que ejerce al investigar y desarrollar nuevas tecnologías que involucran el acceso al genoma humano y su aplicación en tratamientos, y la longevidad. Desde la década de 1990 la comunicación muestra y reproduce representaciones de la vejez y, en este siglo, ha contribuido a la inclusión de las personas mayores en la sociedad, especialmente a través de la construcción de nuevas identidades. El Plan de Acción de Madrid provee el marco para incorporar la discusión acerca del envejecimiento de la población en el debate internacional sobre la implementación de políticas para responder al reto de construir una sociedad para todas las edades. El Plan vela por un entorno propicio y de apoyo para las personas de edad y favorece el desarrollo de la comunicación como primer derecho humano. En su calidad de participantes en el entorno social, los medios de comunicación están revelando diferentes procesos y formas de envejecer, poniendo en evidencia valores de referencia positivos de esta etapa de la vida y mostrando que las personas mayores reconocen que la situación actual requiere nuevos conocimientos y vivencias heterogéneas. Prolongation of life and changes that occur in the ageing process calls our attention to the absence of information related to old age itself, the consequences of science advances and impacts in researches, the development of new technologies that involve the access and use of the Human Genome, treatments and longevity. Since the 90s, communication presents and reproduces representations of old age and in this century it has contributed for the inclusion of elderly people in the society, especially through the construction of new age identities. Madrid Action Plan provides the legal framework to incorporate

  5. Melanoma

    Science.gov (United States)

    ... Lentigo maligna melanoma; Melanoma in situ; Superficial spreading melanoma; Nodular melanoma; Acral lentiginous melanoma ... and brown. It is most common in Caucasians. Nodular melanoma usually starts as a raised area that is ...

  6. El papel de la simulación de la experiencia en el comportamiento humano

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    Juan Francisco Muñoz

    2011-07-01

    Full Text Available Abstract This review article highlights the imagination as the factor that plays a crucial role in the way people compare, assess, describe and explain their experiences. It also discusses the origin of the human imagination, suggesting a joint effect: The evolution of forms of social interaction and simulated alternatives, development of ultra-social adaptations and the development of evolutionary strategies evolved for cooperation. This effect seems to have given rise to a particularly human quality that makes learning the species Homo sapiens be qualitatively different from that occurs in others. This quality is the simulation of experience, a psychological mechanism resulting in millions of years of evolution, which enables many of the qualities most characteristic of human beings. At the end, they share some ideas about how you can research in psychology in the light of these theories. Resumen En este artículo de revisión se resalta a la imaginación como el factor que cumple una función decisiva en la forma como las personas comparan, valoran, describen y explican sus experiencias. También se discute sobre el origen de la imaginación humana, planteando un efecto conjunto entre: La evolución de las formas de interacción social simuladas y sustitutivas, el desarrollo de adaptaciones ultra-sociales y el desarrollo de estrategias evolutivas evolucionadas para la cooperación. Este efecto parece haber dado origen a una cualidad particularmente humana, que hace que el aprendizaje de la especie Homo sapiens sea cualitativamente distinto al que se da en otras. Tal cualidad es la simulación de la experiencia, un mecanismo psicológico resultante de millones de años de evolución, que posibilita muchas de las cualidades más características de los seres humanos. Al final, se comparten algunas ideas sobre cómo puede ser la investigación en Psicología a la luz de estas teorías.

  7. Melanoma

    Science.gov (United States)

    Melanoma is the most serious type of skin cancer. Often the first sign of melanoma is a change in the size, shape, color, or feel of a mole. Most melanomas have a black or black-blue area. Melanoma ...

  8. Inmunodiagnóstico de la infección en humanos por Trypanosoma cruzi mediante ELISA utilizando sangre recolectada en papel de filtro

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    Luis C. Orozco

    1999-06-01

    Full Text Available Los estudios seroepidemiológicos para la detección de anticuerpos contra Trypanosoma cruzi requieren de un gran número de muestras y la obtención de sangre por punción venosa y su transporte se hacen difíciles y costosos. La recolección de sangre en papel de filtro minimiza éstas dificultades y el estudio valoró tanto éste sistema como la validez y reproducibilidad del inmunoensayo ELlSA para el inmunodiagnóstico de la infección en humanos por T cruzi Se utilizó suero y eluídos de sangre recolectada en papel de filtro de personas de zona endémica de enfermedad de Chagas para la detección de anticuerpos contra T cruzi mediante las pruebas de inmunofluorescencia indirecta (IFI y ELISA. Lavalidez del ELlSA utilizando eluídos de sangre en papel de filtro presentó un área bajo la curva de receptor operador (ROC de 0.9944. El acuerdo del ELlSA entre los dos tipos de muestra presentó una distribución cercana a la normal con un promedio de -0.01 y una desviación estándar de 0.23. Se evidenció que la reproducibilidad del IFI es inferior a la del ELISA. Esta mayor concordancia y la mayor sensibilidad y especificidad encontrada previamente para el ELISA hacen pensar en la posibilidad de presentarla como alternativa de prueba de referencia para la detección de anticuerpos contra 7: cruziy su utilización en estudios epidemiológicos.

  9. El papel de actores transnacionales a propósito de la situación derechos humanos en Venezuela

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    Falah, Natalia

    2015-01-01

    A partir de febrero de 2014, la historia de la República Bolivariana se fracturó. El descontento popular, la protesta social y las marchas pacíficas son reprimidas como consecuencia de un abuso de poder por parte del gobierno del presidente Nicolás Maduro. Las redes de información y comunicación, en los términos de Margaret Keck y Kathryn Sikkink, han jugado un papel fundamental para poner en evidencia las violaciones sistemáticas a los DD.HH., siendo estos el factor principal que vulnera la ...

  10. ¿qué papel juega la definición de la eudaimonía en la concepción del bien humano de aristóteles?

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    Velásquez, Beatríz Alejandra

    2012-01-01

    Aristóteles propone una concepción del bien humano que determina (hasta con un cierto grado de precisión) cómo hemos de ser, actuar y en general vivir. Tal concepción se logra, según él, definiendo el bien humano, y en EN 1.7 lo define como “una actividad del alma según la virtud”. Esta definición no brinda información acerca de cómo ser y actuar, por lo que parece no contener la concepción esperada del bien, lo cual sí logra la teoría de la virtud presentada en libros posteriores. ¿Qué papel...

  11. Melanoma

    Science.gov (United States)

    ... if they're dark skinned, young, and have no family history. Even for them, behaviors like too much sun exposure and not enough skin protection are important risk factors. How Do People Know They Have It? Many melanomas start out as a mole or a bump ...

  12. O papel da atenção humana na comunicação cão-ser humano por meio de um teclado

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    Carine Savalli Redigolo

    2009-01-01

    O estudo da comunicação animal-ser humano mediada por signos arbitrários concentrou-se tradicionalmente em chimpanzés, bonobos, golfinhos e papagaios. O cão doméstico (Canis familiaris), na medida em que adaptado pela domesticação à interação com o ser humano, constitui um modelo interessante para a análise dos processos de comunicação interespecíficos. Sofia, o sujeito do presente estudo, é uma cadela treinada a usar um teclado, pressionando teclas com símbolos arbitrários (lexigramas), para...

  13. El papel del antropólogo en la protección de los derechos humanos de los pueblos indígenas

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    David Martín-Castro

    2006-05-01

    Full Text Available El texto es una reflexión sobre el papel que el autor considera deben jugar los antropólogos en su relación con los pueblos indígenas. El autor recoge la percepción y critica de algunos representantes indígenas hacia los antropólogos e intenta responder a los motivos que les llevan a dicha crítica.

  14. El papel del capital público y el capital humano en el crecimiento de las CC.AA. españolas: un análisis mediante datos de panel

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    Ramón María-Dolores

    2005-11-01

    Full Text Available En este trabajo se observa el papel del capital público y humano en la renta y el crecimiento a largo plazo de las CC.AA.españolas mediante una versión extendida del modelo de crecimiento de Solow y se contrasta la principal implicación del mismo de que el crecimiento económico a largo plazo viene determinado solamente por el progreso técnico,que es exógeno.Con dicho fin se estima un panel de datos con efectos fijos y se obtienen varios resultados de interés. En primer lugar,se obtienen conclusiones favorables sobre la capacidad predictiva del modelo de Solow para las CC.AA. españolas, dado su alto grado de ajuste y el cumplimiento de la principal restricción del modelo.No obstante,se encuentra evidencia en contra de la otra predicción básica del modelo de Solow de que el crecimiento a largo plazo viene determinado solamente por el progreso técnico,que es exógeno. La principal razón es la fuerte correlación observada entre el crecimiento de la población ocupada y la tasa de crecimiento de la producción por empleado. También se obtiene un papel relevante del capital humano. En segundo lugar, se elabora una medida de la tasa de crecimiento de la Productividad Total de los Factores (PTF utilizando el índice de Divisia-Tornqvist y se obtiene que es independiente de la inversión en capital privado y de la tasa de crecimiento de la población ocupada. Solamente aparecen ligeramente significativas la inversión en capital humano y la inversión en capital público.Este resultado si sería más consistente con las predicciones del modelo de Solow.

  15. Perceções do sistema de gestão de recursos humanos e o papel da confiança organizacional

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    Oliveira, Ana Teresa Martins Ferreira de

    2014-01-01

    Tese de doutoramento em Psicologia (área de especialização em Psicologia do Trabalho e das Organizações) A gestão de recursos humanos (GRH) é um fenómeno organizacional complexo e multi-dimensional (Keating, 2007). Define regras, estrutura procedimentos entre os colaboradores e as organizações, pode ser formalizada ou não, e possui diferentes objetivos organizacionais. A compreensão do seu impacto, quer ao nível dos colaboradores, quer ao nível das organizações, é consequentemente...

  16. Contactos, especialización y litigios. Una revisión del papel del capital humano y social en la profesión legal.

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    Larrosa, Juan M.

    2004-06-01

    Full Text Available La profesión legal representa un sector laboral gravitante tanto en la política cómo en la economía de países desarrollados y subdesarrollados. Su trabajo en el sector privado consiste en atender las demandas de consultoría legal de los clientes ¿Qué recursos utilizan los profesionales para acercar dicha demanda a su propia oferta? Mucho de su trabajo en el sector privado es obtenido gracias al nivel de capital humano del profesional mientras que otro tanto lo es a través del uso de los recursos insertos en su capital social. El capital humano representa los conocimientos específicos de un profesional para desenvolverse profesionalmente. El capital social, por otra parte, representa la inversión de un individuo en relaciones sociales con retornos esperados. Este trabajo realiza una revisión de la bibliografía enfocándose en la profesión de abogados y su relación con estas dimensiones del capital. Particular interés se presta a la relación que existe entre estas formas de capital y la efectividad en el desempeño profesional.

  17. Papel del factor de crecimiento epidérmico recombinante humano “Heberprot-P” en un paciente con Lepra Multibacilar

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    Wilver Velázquez Chacón

    2014-08-01

    Full Text Available Se presenta el caso de un paciente masculino de 59 años de edad, tratado por vías convencionales a causa de lesiones ulcerativas de miembros inferiores, de más de siete años de evolución, sin diagnóstico y tratamiento. La evolución ulterior permitió reconocer la aparición subsecuente de lepra multibacilar. La basiloscopía fue positiva, indicando el diagnóstico de las lesiones ulcerativas, que se trataron con el uso de factor de crecimiento epidérmico recombinante humano en su formulación Heberprot-P, permitiendo la granulación de las lesiones en toda su extensión en un plazo corto, de 16 días, sin que se presentaran eventos adversos graves. Su resultado final fue satisfactorio

  18. EL PAPEL DE LA CORTE PENAL INTERNACIONAL EN LA PROTECCIÓN DE LOS DERECHOS HUMANOS / THE ROLE OF INTERNATIONAL CRIMINAL COURT IN THE PROTECTION OF THE HUMAN RIGHTS

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    Susana Arango Haupt

    2014-10-01

    Full Text Available El presente artículo tiene como finalidad presentar los puntos más relevantes del papel de la Corte Penal Internacional en la protección de los derechos humanos. Para lo anterior, se centrará en explicar las disposiciones estatutarias más importantes sobre la participación de las víctimas durante todas las etapas procesales, teniendo en cuenta los derechos del acusado. Especial atención prestará al carácter distintivo del Estatuto en relación con los delitos de carácter sexual. Abordará también dos casos específicos, el de Callixte Mbarushimana y el de Thomas Lubanga Dyilo. Los susodichos permitirán entender que el cumplimiento de los deberes tanto de las Salas como de la Fiscalía principalmente respecto del estudio de crímenes de carácter sexual, depende en gran medida de la estrategia de litigio y de la formación de los Jueces en relación con la violencia sexual. La importancia de ambos casos reside en el hecho que la Sala Primera de Cuestiones Preliminares determinó no confirmar los cargos en contra de Mbarushimana debido a los deficientes medios probatorios aducidos por la Fiscalía, en tanto que el caso de Thomas Lubanga ha sido el único hasta ahora decidido por la Corte. Además del hecho que en este último caso la Fiscalía no imputó cargos relacionados con delitos sexuales en contra del acusado, y la mayoría de la Sala de Juicio decidió no incluir las ofensas sexuales como constitutivas de la utilización de menores en un conflicto armado. El artículo culminará su análisis haciendo alusión al principio de complementariedad, especialmente a la complementariedad positiva. Teniendo en cuenta este punto, resaltará las falencias de la Fiscalía en el análisis preliminar de la situación de Colombia y cómo las mismas han conllevado a que no se extienda una solicitud formal de investigación. La relevancia de este caso particular reside en que la Fiscalía no tiene criterios claros de valoración de la situaci

  19. Profesores universitarios y derechos humanos

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    Peralta-Varela, Carlos; Pérez-Viramontes, Gerardo

    1997-01-01

    Se presentan algunas reflexiones sobre la forma como los textos internacionales entienden la relación educación-derechos humanos, a partir de la idea de la educación como el instrumento más importante para conformar una cultura universal de respeto a los derechos humanos. Se presenta la situación que guardan la educación y los derechos humanos en América Latina y en particular en México, así como el papel que se les asigna a los maestros para hacer que los valores universales se reafirmen en ...

  20. O papel do Gene Reck como marcador tumoral de melanoma : função e regulação dos transcritos RECKB e RECKA

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    Jacomasso, Thiago

    2014-01-01

    Orientadora : Profª Drª Sheila Maria Brochado Winnischofer Tese (doutorado) - Universidade Federal do Paraná, Setor de Ciências Biológicas, Programa de Pós-Graduação em Ciências : Bioquímica. Defesa: Curitiba, 28/03/2014 Inclui referências Resumo: RECK (reversion-inducing cysteine rich protein with Kazal motifs) é descrito como um supressor tumoral, e a manutenção de níveis elevados correlaciona com um melhor prognóstico para pacientes portadores de diversos tipos de câncer. O papel ...

  1. Recursos basados en el conocimiento, capacidades dinámicas e innovación en el sector servicios : el papel antecedente de las prácticas de recursos humanos

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    Nieves, Julia

    2013-01-01

    Programa de doctorado: Nuevas tendencias estratégicas en administración y dirección de empresas [ES] El principal objetivo de esta tesis es desarrollar un modelo que explore la relación entre recursos basados en el conocimiento e innovación, considerando el papel mediador de las capacidades dinámicas y el papel antecedente de distintas configuraciones de prácticas de RRHH. Además, se contrasta la validez del modelo teórico propuesto mediante el diseño de una investigación empírica enmarcad...

  2. Estudio del cáncer cutáneo no melanoma en pacientes trasplantados renales : incidencia y factores de riesgo asociados

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    Bernat García, Josefa

    2013-01-01

    El cáncer cutáneo no melanoma (CCNM) es la neoplasia maligna más frecuente en pacientes trasplantados. Los objetivos fundamentales de esta tesis han sido valorar los factores de riesgo asociados a la aparición de CCNM en pacientes trasplantados renales en nuestra área, haciendo hincapié en el papel del tratamiento inmunosupresor y la implicación del virus del papiloma humano (VPH) en la etiopatogenia tumoral. Recogimos los datos de 289 pacientes trasplantados renales durante el periodo 1...

  3. Oxitocina e comportamento humano Oxitocina y comportamiento humano Oxytocin and human behavior

    OpenAIRE

    Diana Catarina Ferreira de Campos; João Manuel Garcia do Nascimento Graveto

    2010-01-01

    Recentemente, têm surgido numerosas especulações sobre o papel da oxitocina nas emoções e relações sociais do ser humano. O presente artigo retrata um estudo essencialmente reflexivo sobre o papel da oxitocina no comportamento humano. A pesquisa bibliográfica foi efectuada nas bases de dados MEDLINE, versão PubMed e CINAHL. Os principais resultados das pesquisas sustentam que os níveis de oxitocina aumentam em resposta à aplicação de massagem e indução de emoções positivas. A administração in...

  4. Avances doctrinarios para la teoría democrática y los derechos humanos relacionados con la participación política: Integridad, equidad en la contienda electoral y el nuevo papel de los jueces electorales

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    Ricardo Valverde Gómez

    2016-01-01

    Full Text Available Si se reconoce que la participación política es una de las mejores maneras de aproximar a los derechos humanos, forzosamente hay temas como la cultura democrática, la democratización, la participación electoral tanto de partidos políticos y ciudadanos como de otros actores sociales que juegan roles fundamentales en las elecciones, que deben ser tomados en cuenta. Para que las condiciones y eventuales regulaciones (o ninguna, si es que ello se enmarca en los textos constitucionales estén muy claras para todos, sobre todo en el caso de los actores principales del proceso electoral -como son los organismos electorales, partidos y candidatoses necesario que su participación se dé en respeto de una base fundamental que es la equidad. Por eso, una de las más fecundas evoluciones doctrinarias actuales parte de la idea de que los procesos electorales deben estar caracterizados por su integridad, o sea, que todas las etapas de dicho proceso deben ser cumplidas a cabalidad para poder calificar una elección en su conjunto, en su globalidad de partes, como una buena elección. Si la teoría y la institucionalidad electoral avanzan de manera progresiva, progresista y virtuosa, se espera que las personas encargadas de dirigir organismos electorales, en particular el caso de los jerarcas que asumen el delicado papel de administrar justicia electoral, estén profesional y técnicamente, pero sobre todo filosóficamente a la altura del papel histórico y político que deben jugar.

  5. Justicia, emociones y derechos humanos

    OpenAIRE

    Baum, Erica

    2011-01-01

    Los conflictos humanos llevados a la justicia poseen un componente emocional irreductible: sentimos ira ante el daño, temor ante una amenaza y vergüenza ante una humillación. Las emociones morales, por otro lado, se distinguen de las emociones básicas que experimentan otras especies animales no humanas por su contenido evaluativo y cognitivo. Interactúan con la razón, revelándonos el estado de vulnerabilidad que nos es inherente. Hay una larguísima discusión filosófica sobre el papel de dicha...

  6. The PRONUCLEAR role (1976-1986) in the human resource training for the nuclear area in Brazil: science history; O papel do PRONUCLEAR (1976 -1986) na formacao de recursos humanos para a area nuclear no Brasil: historia da ciencia

    Energy Technology Data Exchange (ETDEWEB)

    Schmiedecke, Winston Gomes

    2006-07-01

    In 1975, an agreement between the governments of Brazil and West-Germany was signed for the construction of nuclear power plants in Brazil as well as the extraction, processing and enrichment of uranium. As the result of the first oil crisis and facing the perspective of a continuous world energy crisis, the Brazilian government decided to turn to nuclear power as an alternative supply for the country's energy needs. However, serious limitations were present regarding the transfer of nuclear technology for a third world country. This paper analyzes some aspects of the process involved in the creation of the specialized human resources during the extent of the agreement between Brazil and West Germany. Since its inception, the agreement received harsh criticism from the Brazilian nuclear physics and related fields scientific communities. Because the planning and implementation of the agreement took place during a period of military dictatorship, the decisions relating to the agreement were never debated between the policy makers and the scientific community. Not surprisingly, the agreement received plenty of criticism that ranged from the actual need for nuclear power to technical feasibility and suspicious of possible military uses and even the very policies created to prepare human resources to work in the nuclear area. One of the most important tools of these policies was the Programa de Recursos Humanos para o Setor Nuclear - PRONUCLEAR (Nuclear Sector Human Resources Program), implemented in 1976 and gradually deactivated starting in 1983. (author)

  7. Melanoma genetics

    DEFF Research Database (Denmark)

    Read, Jazlyn; Wadt, Karin A W; Hayward, Nicholas K

    2015-01-01

    Approximately 10% of melanoma cases report a relative affected with melanoma, and a positive family history is associated with an increased risk of developing melanoma. Although the majority of genetic alterations associated with melanoma development are somatic, the underlying presence of herita......Approximately 10% of melanoma cases report a relative affected with melanoma, and a positive family history is associated with an increased risk of developing melanoma. Although the majority of genetic alterations associated with melanoma development are somatic, the underlying presence...... in a combined total of approximately 50% of familial melanoma cases, the underlying genetic basis is unexplained for the remainder of high-density melanoma families. Aside from the possibility of extremely rare mutations in a few additional high penetrance genes yet to be discovered, this suggests a likely...... polygenic component to susceptibility, and a unique level of personal melanoma risk influenced by multiple low-risk alleles and genetic modifiers. In addition to conferring a risk of cutaneous melanoma, some 'melanoma' predisposition genes have been linked to other cancers, with cancer clustering observed...

  8. Los edulcorantes y su papel en el metabolismo humano

    OpenAIRE

    Cernuda, J.A. (José); Fernández, Andrea

    2016-01-01

    Introduction Sweetener agents are substances very used currently as a replacement of sugar within human regular diet. In this article we review their effects over the human metabolism and health. Description After his appearance and interest in the beneficial effects attributed to sweetener agents, their jobs increasingly are more numerous. However, there are studies that appear to confirm the ineffectiveness of their use and even show a specific causal association between v...

  9. El recurso humano factor de competitividad en el sector salud

    Directory of Open Access Journals (Sweden)

    Remedios Piteres Redondo

    2017-10-01

    Full Text Available Objetivo: realizar un análisis del papel que juega la gestión del recurso humano al interior de una organización que busca la competitividad.Resultados y conclusiones: el talento humano de una empresa constituye el activo más valioso de la misma, es por esto que una buena gestión del talento humano se debe  caracterizar por potenciar el capital humano en beneficio de los objetivos, visualizando  a los empleados como socios para que a través de sus talentos desarrollen las  estrategias, antes que a través de acciones administrativas generando  una ventaja competitiva en el mercado e impactando  positivamente los diversos programas y políticas, así como los estados financieros de la empresa.

  10. El cuerpo humano

    OpenAIRE

    Tamir, Abraham; Ruiz Beviá, Francisco

    2015-01-01

    El cuerpo humano es la estructura completa del humano y comprende cabeza, cuello, tronco (que incluye el tórax y el abdomen), brazos y manos, piernas y pies. Cada parte del cuerpo se compone de varios tipos de células. En la madurez, el número medio estimado de células en el cuerpo es de 37.2 billones. La composición del cuerpo humano la constituyen un número de ciertos elementos químicos como Ca+2, Na+, K+, C, en diferentes proporciones. El estudio del cuerpo humano implica la anatomía (desc...

  11. Thin melanoma.

    Science.gov (United States)

    Elder, David E

    2011-03-01

    The incidence of malignant melanoma is increasing and a preponderance of the melanomas diagnosed today are "thin in terms of Breslow criteria. Although thin melanomas, as a group, are associated with a very good prognosis, a subset of these tumors may metastasize and cause death. These cases can be identified by using prognostic models, including the "standard" American Joint Committee on Cancer criteria, and other attributes identified in follow-up studies. To review the history of concepts of prognostic modeling in melanoma, focusing on thin melanomas. Selected literature. About 40 years ago, it was realized that malignant melanoma, once almost uniformly fatal, could be divided into categories with better or worse prognosis through the use of prognostic models. The first simple models, Clark levels of invasion and Breslow thickness, are still in use. Thickness remains the single most useful variable. Breslow recognized that melanomas less than 0.76 mm in thickness were associated with a very good prognosis, with no metastases in his limited initial study. The American Joint Committee on Cancer selected a cutoff of 1.0 mm, which achieves a similar result, with stage modifiers, although some metastases and deaths do occur with stage I lesions. Clark demonstrated an almost equally good prognosis for his level II invasive melanomas and recognized that most of these lesions, although invasive, lacked the ability to form tumors or to undergo mitosis in the dermis and were therefore "nontumorigenic" and "nonmitogenic" and lacked competence for metastasis. Studies of these low-risk melanomas have led to the development of criteria for earlier diagnosis and a steady, but still inadequate, improvement in prognosis for melanoma overall. Multivariable models currently can identify groups of patients within the "thin melanoma" category whose prognosis varies, from a disease-free survival of close to 100% to about 70%. Prognosis declines more or less linearly with increasing

  12. Ocular Melanoma

    Science.gov (United States)

    ... also occur on the conjunctiva . Because most eye melanomas form in the part of the eye you can’t see when looking in a mirror, they can be difficult to detect. Also, eye melanoma typically doesn’t cause early signs or symptoms . ...

  13. Malignant melanoma

    NARCIS (Netherlands)

    de Braud, Filippo; Khayat, David; Kroon, Bin B. R.; Valdagni, Riccardo; Bruzzi, Paolo; Cascinelli, Natale

    2003-01-01

    In the European Community cutaneous melanoma accounts for 1 and 1.8% of cancers occurring in men and women, respectively. The incidence rate is increasing faster than that of any other tumour. Sun exposure, patient's phenotype, family history, and history of a previous melanoma are the major risk

  14. Derechos humanos y prensa

    Directory of Open Access Journals (Sweden)

    Jorge Acevedo Rojas

    2015-01-01

    Full Text Available Pese a que la sociedad peruana en la década de los 90 se convirtió en dura cuestionadora de la violación de los derechos humanos, según estimaciones de organismos de defensa de derechos humanos, la violencia política causada en el Perú cobró más de 28 mil muertes, a pesar de la derrota de Sendero Luminoso. El artículo cuenta el problema, la reactualización de este, la contradicción flagrante, la percepción de los derechos humanos, los avances y retrocesos.

  15. Malignant Melanoma

    Directory of Open Access Journals (Sweden)

    Eshini Perera

    2013-12-01

    Full Text Available Melanomas are a major cause of premature death from cancer. The gradual decrease in rates of morbidity and mortality has occurred as a result of public health campaigns and improved rates of early diagnosis. Survival of melanoma has increased to over 90%. Management of melanoma involves a number of components: excision, tumor staging, re-excision with negative margins, adjuvant therapies (chemo, radiation or surgery, treatment of stage IV disease, follow-up examination for metastasis, lifestyle modification and counseling. Sentinel lymph node status is an important prognostic factor for survival in patients with a melanoma >1 mm. However, sentinel lymph node biopsies have received partial support due to the limited data regarding the survival advantage of complete lymph node dissection when a micrometastasis is detected in the lymph nodes. Functional mutations in the mitogen-activated pathways are commonly detected in melanomas and these influence the growth control. Therapies that target these pathways are rapidly emerging, and are being shown to increase survival rates in patients. Access to these newer agents can be gained by participation in clinical trials after referral to a multidisciplinary team for staging and re-excision of the scar.

  16. Biodistribution dosimetric study of radiopharmaceutical {sup 99mT}c Ixolaris in mice for melanoma diagnosis by molecular image and translational model for human beings; Estudo dosimetrico da biodistribuicao do radiofarmaco Ixolaris-{sup 99m}Tc em camundongos para diagnostico de melanoma atraves de imagem molecular e modelo translacional para humanos

    Energy Technology Data Exchange (ETDEWEB)

    Soriano, Sarah Canuto Silva

    2015-07-01

    The labeling of Ixolaris with {sup 99m}Tc was developed by Barboza et.al. (2013) aiming its use primarily in glioblastoma and after in melanoma diagnosis, a less common but very aggressive cancer and with high mortality rate. Preliminary tests on animals have proven its effectiveness of labeling but a dosimetric study to human clinical trials should be performed. This study aimed to: (1) determine the biokinetic model for the radiotracer {sup 99m}Tc-Ixolaris in mice by imaging dosimetry method; and (2) estimate the absorbed and effective dose resulting from the use of a new radiopharmaceutical for melanoma and metastases diagnosis in human beings, since a dosimetric study of new radiopharmaceuticals in animals is necessary to test them subsequently in humans and apply for registration in ANVISA. According to SPECT images, was found a latency period of 15 to 21 days for the development of lung metastasis in mice. Three C57BL6 mice, one control animal, and two animals with induced cell line B16-F10 murine melanoma were tested. The {sup 99m}Tc-Ixolaris radiopharmaceutical was administered intravenously in a caudal vein, and SPECT images were acquired 0.5 h, 1.5 h, 2.5 h, 3.5 h and 24 h post-administration for analysis and biodistribution quantification. The biokinetic model was determined and thus, obtained cumulative activity in order to estimate the absorbed dose in each organ. The mass and metabolic differences between mice and humans were considered and used to extrapolate the data acquired at different scales. Based on dose factors provided by the software MIRDOSE and Olinda (S factor), absorbed doses in irradiated target organs were calculated for the source organs, and finally the effective dose was estimated. The results indicate that for diagnostic exams conducted in human melanoma patients by administering approximately 25.7 MBq the estimated effective dose was 4.3 mSv. Comparing with effective doses obtained in other diagnostic techniques with {sup 99m

  17. Uveal Melanoma

    International Nuclear Information System (INIS)

    Papastefanou, V. P.; Cohen, V. M. L.; Cohen, V. M. L.

    2011-01-01

    Uveal melanoma is the most common primary intraocular malignancy and the leading primary intraocular disease which can be fatal in adults. In this paper epidemiologic, pathogenetic, and clinical aspects of uveal melanoma are discussed. Despite the advance in local ocular treatments, there has been no change in patient survival for three decades. Development of metastases affects prognosis significantly. Current survival rates, factors predictive of metastatic potential and metastatic screening algorithms are discussed. Proposed and emerging treatments for uveal melanoma metastases are also overviewed. Current advances in genetics and cytogenetics have provided a significant insight in tumours with high metastatic potential and the molecular mechanisms that underlie their development. Biopsy of those lesions may prove to be important for prognostication and to allow further research into genetic mutations and potential new therapeutic targets in the future

  18. Papel dos besouros (Insecta, Coleoptera na Entomologia Forense

    Directory of Open Access Journals (Sweden)

    Wellington Emanuel dos Santos

    2014-12-01

    Full Text Available Esse trabalho apresenta uma revisão do papel que os besouros (Insecta, Coleoptera desempenham na Entomologia Forense. Discussões sobre ocorrência em cadáveres humanos e carcaças animais, estimativas de Intervalo Pós-Morte (IPM, estudos realizados no Brasil e em outros países, principais famílias de importância forense e aspectos biológicos, ecológicos e biogeográficos das espécies são apresentadas.

  19. Papel dos besouros (Insecta, Coleoptera) na Entomologia Forense

    OpenAIRE

    Wellington Emanuel dos Santos

    2014-01-01

    Esse trabalho apresenta uma revisão do papel que os besouros (Insecta, Coleoptera) desempenham na Entomologia Forense. Discussões sobre ocorrência em cadáveres humanos e carcaças animais, estimativas de Intervalo Pós-Morte (IPM), estudos realizados no Brasil e em outros países, principais famílias de importância forense e aspectos biológicos, ecológicos e biogeográficos das espécies são apresentadas.

  20. Oxitocina e comportamento humano Oxitocina y comportamiento humano Oxytocin and human behavior

    Directory of Open Access Journals (Sweden)

    Diana Catarina Ferreira de Campos

    2010-07-01

    Full Text Available Recentemente, têm surgido numerosas especulações sobre o papel da oxitocina nas emoções e relações sociais do ser humano. O presente artigo retrata um estudo essencialmente reflexivo sobre o papel da oxitocina no comportamento humano. A pesquisa bibliográfica foi efectuada nas bases de dados MEDLINE, versão PubMed e CINAHL. Os principais resultados das pesquisas sustentam que os níveis de oxitocina aumentam em resposta à aplicação de massagem e indução de emoções positivas. A administração intranasal de oxitocina aumenta os níveis de calma, diminui o nível de ansiedade e promove comportamentos de confiança entre as pessoas. Uma melhor compreensão dos mecanismos neurobioquímicos e biológicos do comportamento humano têm implicações cruciais para o desenvolvimento do conhecimento científico sobre patologias psiquiátricas com especial handicap nas relações sociais (exemplo: autismo, esquizofrenia, personalidade borderline.Recientemente, han surgido numerosas especulaciones sobre el papel de la oxitocina en las emociones y relaciones sociales del ser humano. El presente artículo retrata un estudio esencialmente reflexivo sobre el papel de la oxitocina en el comportamiento humano. La investigación bibliográfica fue efectuada en las bases de datos MEDLINE, versión PubMed y CINAHL. Los principales resultados de la investigación sustentan que los niveles de oxitocina aumentan en respuesta a la aplicación del masaje e inducción de emociones positivas. La administración intranasal de oxitocina aumenta los niveles de tranquilidad, disminuye el nivel de ansiedad y promueve comportamientos de confianza entre las personas. Una mejor comprensión de los mecanismos neurobioquímicos y biológicos del comportamiento humano tiene implicaciones cruciales para el desarrollo del conocimiento científico sobre patologías psiquiátricas con especial handicap en las relaciones sociales (ejemplo: autismo, esquizofrenia

  1. Derechos humanos y empresas

    OpenAIRE

    Domínguez Martín, Lidia

    2017-01-01

    Sólo a partir de finales del siglo XX, las empresas se han empezando a concienciar de la incidencia que puede tener su actuación en los derechos humanos y de la necesidad de integrar enfoques de responsabilidad social empresarial, no sólo por razones éticas, sino porque beneficia a los negocios y a la sociedad en general. Sin embargo, todavía son muchas las empresas que siguen vulnerando derechos humanos y, por ello, se han ido desarrollando una serie de iniciativas para garantizar que los re...

  2. Malignant Melanoma of the Foot

    Science.gov (United States)

    ... Javascript in your browser. Malignant Melanoma of the Foot What Is Malignant Melanoma? Melanoma is a cancer ... age groups, even the young. Melanoma in the Foot Melanoma that occurs in the foot or ankle ...

  3. Valores e Desenvolvimento Humano

    NARCIS (Netherlands)

    F. Comim (Flavio); A. Macedo de Jesus (Anderson); R.C.B Oliveira (Raissa); A. Davison (Anna); S. Galeno (Sabrina); A.C.V. Ribeiro (Ana)

    2010-01-01

    markdownabstractA primeira parte desse Relatório de Desenvolvimento Humano do Brasil 2009/2010 começa com a descrição de um amplo processo de consulta aberta à sociedade, denominada Brasil Ponto a Ponto, para a escolha do tema do relatório. A Campanha Brasil Ponto a Ponto teve por objetivo

  4. Sinclair swine melanoma

    International Nuclear Information System (INIS)

    Hook, R.R.; Berkelhammer, J.; Hamby, C.V.

    1986-01-01

    Sinclair(S-1) miniature swine spontaneously develop melanomas which have many biologic and histologic features in common with human superficial spreading melanoma. Host control of this neoplasm was indicated by the high incidence of spontaneous regression, a decrease in tumor development with age and a decrease in progressive growth of the tumor as age of tumor development increases. Immunologic mechanisms were implicated in host control by histologic observation of a mononuclear inflammatory infiltration of tumors which lead to depigmentation and fibrosis. In vitro immunologic studies revealed that leukocytes from melanoma swine were sensitized specifically to a tumor associated antigen like substance present in extracts of cutaneous melanomas and cultured swine melanoma cells and that melanoma swine leukocytes were cytotoxic for swine melanoma cells. Furthermore, these studies suggested the existence of a common cross reactive, melanoma associated antigen shared by human and swine melanomas. Antigenic analyses of swine melanomas with mouse monoclonal antibodies developed to a single swine melanoma cell culture and with rabbit antisera developed to pooled extracts of cutaneous melanomas demonstrated the presence of tumor associated antigens in swine melanoma cell culture and cutaneous melanomas. The failure of mouse monoclonal antibodies to detect antigens in cutaneous melanoma extracts and the failure of rabbit antisera to detect antigens in melanoma cell culture extracts suggested a differential in antigen expression between swine melanoma cells grown in vitro and in vivo

  5. Choroidal melanoma

    International Nuclear Information System (INIS)

    Hernandez Quesada, Flora

    2013-01-01

    A useful and practical guide is developed to better track to the uveal melanoma, due to its highly malignant character. Melanoma of the uveal tract (choroid, iris, ciliary body) has been the intraocular tumor most frequent in adults. The biopsy has been inaccessible, due to its location; therefore, the diagnostic should be based on clinical examination and the correct utilization of the diagnostic procedures (ultrasound, fluorescent angiography, computed axial tomography and magnetic resonance). The cases are diagnosed in the histological examination of the operatory piece post-enucleation for other causes. Epidemiological research has been key to determine the associated factors and better to understand the mechanisms of onset of the disease. Anatomopathological studies of choroidal melanoma have permitted to know the natural history of the disease. The decrease of the visual acuity, pain or inflammation are presented as a defect in the visual field. Different techniques to diagnose the disease are explained. Ultrasound in mode A and B, computed axial tomography and magnetic resonance are the diagnostic method of election. Ultrasound has been the primary method of diagnostic, giving the size and vascularisation, useful in tracking, when they are treated in shape conservatively, showing changes in echogenicity and less vascularisation as good response to treatment. The treatments of choroidal melanoma are specified. The correct interpretation of the clinical symptoms and early utilization of diagnostic imaging methods, have permitted to establish the adequate therapeutic and to avoid local and distant metastasis. The uveal melanoma, depending on their size and location, traditionally has been treated by enucleation. Data from the literature and authors, have promoted the conservation of the ocular globe, depending on the size of the tumor. Transpupillary thermotherapy has been an available alternative for small tumors in Costa Rica and level of social security

  6. Microsporidios en humanos

    Directory of Open Access Journals (Sweden)

    Ligia Moncada

    1998-09-01

    Full Text Available Se hace una revisión sobre la taxonomía, la biología y los métodos diagnósticos de los microsporidios encontrados en humanos. A partir de 1981 -1982, con el advenimiento de la epidemia de SIDA, han sido muchos los informes sobre casos de microsporidiosis en humanos. Actualmente se han implicado especies correspondientes a los géneros Enterocytozoon, Encephalitozoon, Vittaforma, Pleistophora y Trachipleistophora, en diferentes patologías humanas no sólo en aquellos individuos que tienen algún compromiso del sistema inmune sino también en individuos sanos. Los métodos diagnósticos empleados se basan principalmente en coloraciones de cromotropo modificada y otras técnicas como microscopía electrónica de transmisión (TEM, análisis inmunogénicos y de ácidos nucleicos. La forma de transmisión para los humanos es incierta, pero se han encontrado algunas especies parasitando animales lo que sugiere que puede tratarse de una zoonosis.

  7. Monstruos de papel

    Directory of Open Access Journals (Sweden)

    Joaquín Díaz

    2016-04-01

    Full Text Available ABSTRACT. The expression «literatura de cordel» uniquely brings together all that kinds of papers that were sold in the street exposed to the attention of the public hanging from a string. The contemplation of that kind of papers used to be in the square or in a market and the editor used to search an effect showing an artistic engraving on the cover. To achieve this engraving attracted without hesitation to who is closer to the seller's specifications, it demanded the collaboration of an artist who return to images which otherwise expressed the words of the author of the text and it required that artist who figures –animals or human– they were identifiable, a desirable general vision and at the same time seem relatively close. Treatment given by some of these artists to the themes of the «pliegos» came to be peculiar to its form created a «style» and a repertoire with own personality and aesthetics. This article discusses some of the recurring themes that influenced the creation of a common long-haul mentality. Resumen: La expresión “literatura de cordel” agrupa unívocamente a todo aquel tipo de papeles que eran vendidos en la calle expuestos a la atención del público colgando de una cuerda. La contemplación del pliego solía hacerse en la plaza o en un mercado y el editor solía buscar un efecto mostrando un grabado en la portada. Para conseguir que ese grabado atrajera sin dudar a quien se acercase al vendedor de pliegos, demandaba la colaboración de un artista plástico que trasladase a imágenes lo que de otro modo expresaban las palabras del autor del pliego y exigía a ese artista que las figuras –de animales o humanas- fuesen identificables, respetasen un deseable plano general y al mismo tiempo parecieran relativamente cercanas. El tratamiento dado por algunos de esos artistas a los temas de los pliegos llegó a hacerse tan peculiar que su forma creó un “estilo” y un repertorio con personalidad y est

  8. Contratos de capital humano

    OpenAIRE

    Oscar Alejandro Goyes Viteri

    2005-01-01

    Este documento busca dar a conocer el tema de la inversión en capital humano a través de la celebración de contratos atípicos y utilizando la fiducia mercantil y la titularización como vehículos financieros. Por medio de estos contratos un estudiante obtiene los recursos que requiere para financiar su educación superior, a cambio de entregar un porcentaje de sus ingresos después de su graduación a quien financió la operación.

  9. Contratos de capital humano

    Directory of Open Access Journals (Sweden)

    Oscar Alejandro Goyes Viteri

    2005-01-01

    Full Text Available Este documento busca dar a conocer el tema de la inversión en capital humano a través de la celebración de contratos atípicos y utilizando la fiducia mercantil y la titularización como vehículos financieros. Por medio de estos contratos un estudiante obtiene los recursos que requiere para financiar su educación superior, a cambio de entregar un porcentaje de sus ingresos después de su graduación a quien financió la operación.

  10. Contratos de capital humano

    Directory of Open Access Journals (Sweden)

    Oscar Alejandro Goyes Viteri

    2005-12-01

    Full Text Available Este documento busca dar a conocer el tema de la inversión en capital humano a través de la celebración de contratos atípicos y utilizando la fiducia mercantil y la titularización como vehículos financieros. Por medio de estos contratos un estudiante obtiene los recursos que requiere para financiar su educación superior, a cambio de entregar un porcentaje de sus ingresos después de su graduación a quien financió la operación.

  11. Los Derechos Humanos

    OpenAIRE

    Blanco Quirós, Miguel

    2014-01-01

    Faustino Cordón nos habla del derecho fundamental del científico: "Encontrar en su medio social cauces practicables, que recojan el pensamiento que el vayaganando en su pesquisa de la realidad y que lo conduzcan donde se contraste libremente con el pensamiento general". Para Ramón Tamames, desde el punto devista económico, la Declaración de los Derechos Humanos es una codificación internacional de validez jurídica muy discutida, que resume todas las conquistassociales de los trabajadores en l...

  12. Justicia y derechos humanos

    OpenAIRE

    Joel Flores Rentería

    2011-01-01

    Las libertades básicas y los bienes que contemplan los derechos humanos constituyen los principios de la justicia social y política en los Estados modernos, estos bienes son producto de la evolución histórica, política, cultural y filosófica de la modernidad. Por tal motivo, llevan en sí una conceptualización de lo que es y debe ser la existencia humana; en consecuencia, lo justo sería que toda persona, en una sociedad, se encuentre en posesión de dichos bienes y libertades.

  13. Cixutumumab in Treating Patients With Metastatic Melanoma of the Eye

    Science.gov (United States)

    2015-06-25

    Ciliary Body and Choroid Melanoma, Medium/Large Size; Ciliary Body and Choroid Melanoma, Small Size; Iris Melanoma; Metastatic Intraocular Melanoma; Recurrent Intraocular Melanoma; Stage IV Intraocular Melanoma

  14. El papel de las infraestructuras públicas en el desarrollo regional

    Directory of Open Access Journals (Sweden)

    Pablo Martín Urbano

    2005-01-01

    Full Text Available Dentro de las teorías del desarrollo endógeno, toma relevancia el papel que desempeñan las infraestructuras social y económica. Este papel no está exento de controversia y su impacto en el desarrollo de las regiones ha sido analizado desde varias perspectivas y experiencias. No obstante, en los últimos años se ha revalorado la influencia positiva de las infraestructuras, tanto, que su impacto en términos de externalidades puede ser tan importante como la inversión en capital humano o e desarrollo de tecnología. En este artículo se expone la teoría del desarrollo endógeno y se hace énfasis en el papel de la infraestructura, especialmente como pieza clave del potencial de desarrollo regional.

  15. Direitos humanos na educação: superar os desafios

    OpenAIRE

    Karen Franklin

    2010-01-01

    Resumo:Este artigo apresenta reflexões sobre as dificuldades e os desafios da educação diante da questão dos direitos humanos. São apresentados alguns aspectos fundamentais para reflexão: o princípio de universalidade dos direitos humanos e o papel da filosofia no esclarecimento da experiência ética e da cidadania. Apresentamos algumas concepções necessárias para a conquista do conceito de humanidade atrav&eacu...

  16. Hume e o entendimento humano:estudo introdutório

    Directory of Open Access Journals (Sweden)

    Adriano Naves de Brito

    2007-12-01

    Full Text Available Este trabalho é um estudo introdutório e didático da concepção humeana do entendimento humano.Na primeira parte apresento a concepção empirista em que Hume se inscreve, na segunda são sumariados os principais aspectos de sua teoria acerca do entendimento humano e na última parte teço algumas considerações a propósito do papel da linguagem e do juízo nesta teoria. 

  17. Skin cancer and melanoma

    International Nuclear Information System (INIS)

    Moylan, D.J.

    1991-01-01

    In this chapter, the author discusses various types of non-melanoma malignant skin cancer, as well as malignant melanoma. Non-melanoma skin cancer, such as basal cell and squamous cell carcinomas, occasionally metastasize, but only late in the course of the disease. On the other hand, even relatively small primary melanomas tend to disseminate to regional lymph nodes and to distant sites. The author presents various treatment plans, including radiation therapy. Cutaneous melanomas have been considered relatively radioresistant. This is the rationale for the use of large fraction radiation therapy in the treatment of melanomas with the fraction sizes varying from 4--8 Gy

  18. Glaucoma secundario a melanoma uveal

    Directory of Open Access Journals (Sweden)

    Nairovys Gómez Martínez

    2017-09-01

    Full Text Available Introducción: Los tumores localizados en iris y cuerpo ciliar son poco frecuentes y puede ser valorada su resección local como alternativa terapéutica. El melanoma uveal representa el 79-81% de los melanomas oculares y el 3-5% de todos los melanomas. Objetivo: Dar a conocer el caso de una patología infrecuente con pocos casos reportados en la literatura, enfatizar su importancia dentro de los diagnósticos diferenciales y del estudio histopatológico. Descripción del caso: Paciente femenina de 47 años de edad, quien acudió a la consulta de oftalmología, para valoración de una lesión pigmentada en endotelio corneal y en iris asociada a hipertensión ocular y pérdida de la agudeza visual en el ojo izquierdo de cuatro meses de evolución. La biomicroscopía ultrasónica confirmó la presencia de una masa iridiana, localizada en la periferia del iris. El estudio anatomopatológico mostró una proliferación de células névicas pleomórficas que reemplazaban el estroma normal del iris. Conclusiones: En pacientes que presentan una clínica de glaucoma unilateral refractario a tratamiento farmacológico junto con dispersión de pigmento es importante una exploración exhaustiva destacando el papel de la biomicroscopía ultrasónica.

  19. Hospitalidad, con y sin papeles

    Directory of Open Access Journals (Sweden)

    Ana Paula Penchaszadeh

    Full Text Available Resumen El objetivo de este artículo es vincular el trabajo sobre el archivo de Jacques Derrida con la experiencia de la hospitalidad. Se intentará mostrar que, por un lado, se trata siempre de los papeles, de la legitimidad que éstos otorgan o no tanto a nivel filosófico (deseo de poseer los papeles que autoricen tal o cual decisión interpretativa, como a nivel político ("tener papeles" como el principio básico de todo derecho a tener derechos, de todo derecho a la comunidad. Mas también, por otro lado, se intentará pensar aquello que arruina la idea misma de tener o no tener (papeles, la idea de propiedad, aquello que hace imposible fundar una decisión o identidad en última instancia y, por ende, una soberanía, una frontera. La hospitalidad, la llegada inminente del otro, representa un desafío político y ético para la filosofía: pues no se trata de un saber, sino de una experiencia transformando el sustrato del nos-otros, del ser común.

  20. Treatment Option Overview (Melanoma)

    Science.gov (United States)

    ... Reporting & Auditing Grant Transfer Grant Closeout Contracts & Small Business Training Cancer Training at NCI (Intramural) Funding for ... the skin far away from where it first started. Recurrent Melanoma Recurrent melanoma is cancer that has ...

  1. General Information about Melanoma

    Science.gov (United States)

    ... Reporting & Auditing Grant Transfer Grant Closeout Contracts & Small Business Training Cancer Training at NCI (Intramural) Funding for ... the skin far away from where it first started. Recurrent Melanoma Recurrent melanoma is cancer that has ...

  2. Stages of Melanoma

    Science.gov (United States)

    ... Reporting & Auditing Grant Transfer Grant Closeout Contracts & Small Business Training Cancer Training at NCI (Intramural) Funding for ... the skin far away from where it first started. Recurrent Melanoma Recurrent melanoma is cancer that has ...

  3. Melanoma - neck (image)

    Science.gov (United States)

    This melanoma on the neck is variously colored with a very darkly pigmented area found centrally. It has irregular ... be larger than 0.5 cm. Prognosis in melanoma is best defined by its depth on resection.

  4. Primary ovarian malignant melanoma

    Directory of Open Access Journals (Sweden)

    Kostov Miloš

    2010-01-01

    Full Text Available Background. Primary ovarian malignant melanoma is extremely rare. It usually appears in the wall of a dermoid cyst or is associated with another teratomatous component. Metastatic primary malignant melanoma to ovary from a primary melanoma elsewhere is well known and has been often reported especially in autopsy studies. Case report. We presented a case of primary ovarian malignant melanoma in a 45- year old woman, with no evidence of extraovarian primary melanoma nor teratomatous component. The tumor was unilateral, macroscopically on section presented as solid mass, dark brown to black color. Microscopically, tumor cells showed positive immunohistochemical reaction for HMB-45, melan-A and S-100 protein, and negative immunoreactivity for estrogen and progesteron receptors. Conclusion. Differentiate metastatic melanoma from rare primary ovarian malignant melanoma, in some of cases may be a histopathological diagnostic problem. Histopathological diagnosis of primary ovarian malignant melanoma should be confirmed by immunohistochemical analyses and detailed clinical search for an occult primary tumor.

  5. Molecular Classification of Melanoma

    Science.gov (United States)

    Tissue-based analyses of precursors, melanoma tumors and metastases within existing study populations to further understanding of the heterogeneity of melanoma and determine a predictive pattern of progression for dysplastic nevi.

  6. Melanoma International Foundation

    Science.gov (United States)

    ... the state of Pennsylvania, certificate #29498 © 2013 Melanoma International Foundation. All Rights Reserved. Privacy Policy | Terms of Use Toll-free: 866-463-6663 International: 610-942-3432 Melanoma International Foundation 250 Mapleflower ...

  7. [Ocular melanomas : An update].

    Science.gov (United States)

    Kalirai, H; Müller, P L; Jaehne, D; Coupland, S E

    2017-11-01

    Melanoma is the most common type of primary cancer to affect the adult eye. Approximately 95% of ocular melanomas are intraocular and arise from the uvea (i. e. iris, ciliary body, and choroid), while the remaining 5% are located in the conjunctiva. Although both uveal and conjunctival melanomas are thought to derive from malignantly transformed melanocytes, uveal melanoma is clinically and biologically distinct from conjunctival melanoma, and indeed from its more common cutaneous counterpart. Intense efforts have been recently made to understand the molecular biology involved in the development of ocular melanomas, and in their progression. Molecular advances, particularly for uveal melanoma, have enhanced prognostication and the identification of rational therapeutic targets for disseminated disease. In this review, recent advances in the molecular characterisation of both uveal and conjunctival melanomas are discussed, and how these may be used to develop personalised therapeutic strategies.

  8. VITIMOLOGIA E DIREITOS HUMANOS

    OpenAIRE

    Silva, João Felipe; Faculdades Integradas de Ourinhos. Professor de Ciência Política e Teoria Geral do Estado. Nome do grupo: DEMOCRACIA E DIREITOS FUNDAMENTAIS Status do grupo: certificado pela instituição Ano de formação: 2012 Data da última atualização: 18/04/2013 11:42 Líder(es) do grupo: Fernando de Brito Alves - Edinilson Donisete Machado - Área predominante: Ciências Sociais Aplicadas; Direito Instituição: Universidade Estadual do Norte do Paraná - UENP Órgão: Setor de Pós-Graduação em Direito

    2013-01-01

    As questões atinentes à situação da vítima e seu comportamento frente ao algoz e as formas como se dá a vitimização em seus diversos graus apresenta-se de forma inquietante desde o período imediatamente posterior à Segunda Guerra Mundial. O surgimento da Vitimologia como área do conhecimento, cujo principal objetivo é o resguardo dos Direitos Humanos da vítima concretiza e afirma deforma categórica o quão importante para as ciências penais e criminológicas é a percepção dos aspectos biológico...

  9. de los derechos humanos

    Directory of Open Access Journals (Sweden)

    Javier Pardo Falcón

    2007-01-01

    Full Text Available A pesar de su uso en determinados foros políticos con connotaciones claramente negativas, el término globalización tiene un significado neutro que también puede hacer referencia a fines de bondad indudable. Así, tanto la Declaración Universal de los Derechos Humanos como otros instrumentos internacionales aprobados por las Naciones Unidas son normas jurídicas globalizadoras, surgidas con la idea de extender la vigencia de los derechos básicos de la persona a todos los países del mundo. Desde esta otra visión de la globalización, conseguir la efectiva vigencia de los derechos humanos en los países de Centroamérica resulta una tarea particularmente urgente y necesaria. En efecto, salvo Costa Rica, que puede considerarse una afortunada excepción en la turbulenta historia política centroamericana, todos los demás Estados de la región comparten un pasado marcado por los graves conflictos internos y el escaso desarrollo económico, circunstancias ambas que explican en buena parte un presente caracterizado por la debilidad de las instituciones, la falta de cohesión social y, en consecuencia, la insuficiente garantía de los derechos más básicos de la mayoría de la población. En este contexto, y desde su compromiso con la mejora de las condiciones materiales de vida de sus conciudadanos menos favorecidos, seis autores y autoras centroamericanos abordan, desde distintas perspectivas, la situación actual de los derechos fundamentales en sus respectivos países.

  10. Drug effects on melanoma

    NARCIS (Netherlands)

    Koomen, Elsje Rosalie

    2010-01-01

    Cutaneous melanoma is the most aggressive form of skin cancer and its incidence among Caucasian populations has increased whereas mortality rates are stabilizing or decreasing. The total burden of melanoma is expected to be increasing. As effective treatment options for advanced melanoma are

  11. Burden of Melanoma

    NARCIS (Netherlands)

    C. Holterhues (Cynthia)

    2011-01-01

    markdownabstract__Abstract__ Melanoma is a type of skin cancer that arises from melanocytes. More than 95% of all melanomas occur in the skin, but rarely in the pigmented cells of the eye, meninges or mucosa. This thesis will only regard the invasive cutaneous malignant melanomas.

  12. Genetics of familial melanoma

    DEFF Research Database (Denmark)

    Aoude, Lauren G; Wadt, Karin A W; Pritchard, Antonia L

    2015-01-01

    Twenty years ago, the first familial melanoma susceptibility gene, CDKN2A, was identified. Two years later, another high-penetrance gene, CDK4, was found to be responsible for melanoma development in some families. Progress in identifying new familial melanoma genes was subsequently slow; however...

  13. Cutaneous melanoma in women

    Directory of Open Access Journals (Sweden)

    Mi Ryung Roh, MD

    2017-03-01

    Conclusions: The published findings on gender disparities in melanoma have yielded many advances in our understanding of this disease. Biological, environmental, and behavioral factors may explain the observed gender difference in melanoma incidence and outcome. Further research will enable us to learn more about melanoma pathogenesis, with the goal of offering better treatments and preventative advice to our patients.

  14. Cutaneous melanoma in women

    Directory of Open Access Journals (Sweden)

    Mi Ryung Roh, MD

    2015-02-01

    Conclusions: The published findings on gender disparities in melanoma have yielded many advances in our understanding of this disease. Biological, environmental, and behavioral factors may explain the observed gender difference in melanoma incidence and outcome. Further research will enable us to learn more about melanoma pathogenesis, with the goal of offering better treatments and preventative advice to our patients.

  15. Desenvolvimento humano: contribuições da psicologia moral

    Directory of Open Access Journals (Sweden)

    Yves de La Taille

    2007-03-01

    Full Text Available Procuramos avaliar as contribuições do conhecimento acumulado pela Psicologia Moral para a compreensão do desenvolvimento humano, para sustentar a tese segundo a qual a fonte energética do dever moral precisa ser procurada não só em sentimentos exclusivamente morais, mas também em sentimentos que desempenham um papel para o próprio desenvolvimento humano no seu conjunto. Três são os passos da análise deste artigo. Em primeiro lugar, verifi car se há possibilidade de articulação entre teorias psicológicas que enfatizam a dimensão afetiva da moralidade (Freud e Durkheim e outras que enfatizam a dimensão intelectual (Piaget e Kohlberg. Em segundo lugar, uma vez constatada a impossibilidade dessa articulação, sustentar que o sentimento de vergonha, presente na moralidade mas também em outras dimensões do desenvolvimento humano, é condição necessária ao sentimento de obrigatoriedade. Finalmente, analisar se tal sentimento é passível de ser evocado como fonte energética essencial nas abordagens que enfatizam a dimensão intelectual da moralidade.

  16. El genoma humano

    Directory of Open Access Journals (Sweden)

    García Barreno, Pedro

    2002-01-01

    Full Text Available Not available

    El redescubrimiento de las leyes de Mendel sobre la herencia en las semanas que abrieron el siglo XX incitó una búsqueda científica para comprender la naturaleza y el contenido de la información genética que ha impulsado la biología durante los últimos cien años. El progreso científico conseguido se ha fraguado en cuatro fases que se corresponden, aproximadamente, con los cuatro cuartos del siglo XX. El primero estableció las bases celulares de la herencia: los cromosomas. El segundo definió las bases moleculares de la herencia: la doble hélice de ADN. El tercero descifró las bases informativas de la herencia con el descubrimiento de los mecanismos biológicos mediante los que la célula lee la información codificada en los genes; luego, con la invención de la tecnología del ADN recombinante de clonajey de secuenciación, los científicos pudieron hacer lo mismo. El último cuarto del siglo estuvo marcado por un lento pero constante esfuerzo para descifrar genes primero y, por fin, genomas enteros que han propiciado el desarrollo de la genómica. El día 26 de junio de 2000 se hacía público un «borrador de trabajo» de la secuencia del genoma humano. Las revistas Nature (vol 409, n.º 6822 y Science (vol 291, n.º 5507 dedicaban números especiales a la publicación de la secuencia en el mes de febrero de 2001 (el día 15 Nature y, al día siguiente, Science. «La humanidad ha recibido un gran regalo. La conclusión de la secuencia del genoma humano ofrece una herramienta poderosa para descifrar los secretos de nuestra herencia genética y para precisar nuestro lugar entre otros participantes en la aventura de la vida».

  17. O papel do enfermeiro hoje

    Directory of Open Access Journals (Sweden)

    Luzia Cecília de Medeiros

    1997-06-01

    Full Text Available Este trabalho tem por objetivo analisar o papel do enfermeiro como resultado das transformações históricas ocorridas na enfermagem. O sistema capitalista coloca ao enfermeiro, no modelo clínico de assistência, a função de administrar os serviços e a equipe de enfermagem restringindo assim sua função a primar pela lucratividade e burocracia da empresa. Dessa forma a assistência é delegada a outras categorias profissionais, muitas vezes sem nenhuma qualificação. Nesse universo, entendemos que o enfermeiro tem como papel principal administrar a assistência de enfermagem para ter uma visão do todo e dessa forma desenvolver uma prestação de serviços qualificada e articulada as atuais necessidades da estrutura social.

  18. LINGUAGEM, INTERSUBJETIVIDADE E MOVIMENTO HUMANO

    Directory of Open Access Journals (Sweden)

    Lísia Costa Gonçalves de Araújo

    2005-01-01

    Full Text Available Este estudo aborda o tema do Movimento Humano, num contexto interdisciplinar, com base na ontologia da Linguagem em Merleau-Ponty e na teoria do agir comunicativo em Habermas. A Linguagem é tema central no processo educacional. Está intimamente ligada ao Movimento Humano, pois este cria um dinamismo, através da própria percepção que lhe é inerente, abrindo-nos para novas possibilidades de “ser no mundo”.

  19. Tumor progression in uveal melanoma

    NARCIS (Netherlands)

    C.M. Mooij (Cornelia)

    1995-01-01

    textabstractOphthalmic melanomas can be divided in extra-ocular (conjunctiva, caruncle) and intraocular uveal melanomas (iris, ciliary body and choroid). Uveal melanomas account for 95% of ocular melanomas, while only 5% are conjunctival in origin. The extra-ocular and intra-ocular melanomas differ

  20. El estudio del factor humano en accidentes de aviación

    Directory of Open Access Journals (Sweden)

    Lina María Sánchez Rubio

    2010-01-01

    Full Text Available El factor humano ha sido considerado causa o contribución del 70 al 80% de los accidentes de aviación en el mundo, y constituye una prioridad en investigación para la seguridad aérea. Las estadísticas muestran que los índices y causas de accidentes de aviación se mantienen constantes, e identifican una importante diferencia entre regiones. La investigación científica requiere de nuevas y complementarias aproximaciones para la explicación y comprensión del factor humano en aviación. Los médicos y psicólogos que trabajan en Medicina Aeroespacial y factores humanos desempeñan un importante papel para alcanzar las metas en seguridad aérea.

  1. La gestión de los recursos humanos en el marco de la calidad total

    Directory of Open Access Journals (Sweden)

    María Sol Castro

    1998-12-01

    Full Text Available Las empresas que han implantado la Gestión de la Calidad Total (CGT y que desean sostenerla con éxito, tienen en el tratamiento del lado humano de la calidad una oportunidad única para que los departamentos de recursos humanos (DRH desempeñen un papel protagonista. La necesidad de poner en práctica acciones específicas de gestión de los, recursos humanos sitúa a los DRH en una posición auténticamente estratégica. Les compete la creación y la puesta en marcha de un conjunto de procesos interdependientes de gestión que sirven de apoyo para el desarrollo de la GCT.

  2. Retos y rol estratégico en la gestión del talento humano

    Directory of Open Access Journals (Sweden)

    Juan Carlos Aguilar Joyas

    2016-03-01

    Full Text Available La gestión estratégica del talento humano, como se conoce en las organizaciones de hoy, se caracteriza por la coherencia o el ajuste entre su papel y la estrategia organizacional. Partiendo de esta premisa se desarrolló la investigación para conocer el papel, los retos y las prácticas en la gestión del talento humano (GTH de 16 empresas de la ciudad de Cali, logrando poner en evidencia que estas empresas han tenido avances en cuanto a las prácticas utilizadas para el desarrollo del talento humano frente a la competitividad y las tendencias del mercado, pero igualmente se enfrentan a grandes desafíos en el sentido de fortalecer su orientación estratégica y la medición del valor; se destaca también que los programas de bienestar, la medición de la efectividad del talento humano, los procesos de subcontratación y la compensación son aspectos sensibles en muchas de ellas

  3. PERSPECTIVA DE LA TEORÍA DEL CAPITAL HUMANO ACERCA DE LA RELACIÓN ENTRE EDUCACIÓN Y DESARROLLO ECONÓMICO

    OpenAIRE

    Guadalupe Villalobos Monroy

    2009-01-01

    Se aborda en el artículo un recorrido de la teoría del capital humano desde sus inicios en la posguerra hasta estudios recientes, centrando el análisis en el papel de la educación en la formación del capital humano y en la relación entre capital humano y el desarrollo. En este recorrido se puntualizan los enfoques que se han ido desarrollando. El propósito principal del trabajo es analizar la relación educación y desarrollo, en las concepciones clásicas y en los enfoques recientes del capital...

  4. Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma

    Science.gov (United States)

    2016-05-06

    Acral Lentiginous Malignant Melanoma; Lentigo Maligna Malignant Melanoma; Nodular Malignant Melanoma; Recurrent Melanoma; Solar Radiation-related Skin Melanoma; Stage IV Melanoma; Superficial Spreading Malignant Melanoma

  5. Programa Papel Pasado: Apoyo a las Regularizaciones Fundiarias?

    Directory of Open Access Journals (Sweden)

    Marcelo Lessa da Silva

    2015-12-01

    Full Text Available El presente artículo analizó la efectividad del Programa Papel Pasado del gobierno federal cuya finalidad es el apoyo a las regularizaciones fundiarias de interés social en áreas urbanas con vistas a garantizar el derecho a la vivienda digna y adecuada a las poblaciones de baja renta. Así, buscó en la análisis del ordenamiento jurídico internacional y interno, demostrar el fundamento de validez para el reconocimiento del derecho a la vivienda adecuada como un derecho humano y fundamental social que demanda del Estado el deber de lo garantizar. Se utilizó del método de investigación teórico-dogmática, exploratorio y explicativo, adoptándose una investigación jurídica y social de naturaleza aplicada, cualitativa y cuantitativa, de análisis, documental y bibliográfica. Se constató que la Declaración Universal de los Derechos Humanos reconoce el derecho a la vivienda como un derecho humano, teniendo su concepto, significado y abrangencia mejor detallados en los comentarios y observaciones generales realizados por los comités de los pactos. Además, en el plan nacional el derecho a la vivienda está garantizado, expresamente, en el caput del artículo 6º de la CRFB. Se verificó que a pesar de la Ley 11.977/09 listar otros legitimados a promover la regularización fundiaria de interés social, es el Municipio que detiene los instrumentos necesarios para, efectivamente, providenciar las regularizaciones fundiarias, en cumplimento a la determinación constitucional previstas en los artículos 182 y 183. El problema de los municipios es el presupuesto insuficiente para tamaña responsabilidad, debiendo recibir apoyo técnico-financiero de los demás entes. Sin embargo, delante del análisis de la efectividad del programa Papel Pasado de apoyo a las regularizaciones fundiarias del Gobierno Federal, se constató que, hasta el momento, el programa es totalmente ineficaz para lo que se propone. Porque en la práctica, tras siete a

  6. CONSIDERACIONES PARA LA PLANIFICACIÓN DE RECURSOS HUMANOS EN HOTELES DE LA PROVINCIA DE MANABÍ

    Directory of Open Access Journals (Sweden)

    Rodney Alfonso Alfonso

    2015-10-01

    Full Text Available El objetivo de esta investigación fue realizar consideraciones relacionadas con la actividad de planificación de recursos humanos para las entidades hoteleras de la provincia de Manabí. Se presentó la propuesta de una herramienta para el diagnóstico de la planificación de recursos humanos en entidades hoteleras, que tomó en cuenta la conformación de un equipo de trabajo especializado, una caracterización general del objeto de estudio y de manera específica o detallada del área de recursos humanos. Seguido a esto, se analiza la planificación de recursos humanos, tomando en cuenta factores internos y externos, basándose específicamente en un análisis DAFO ponderado con el criterio de expertos previamente seleccionados y la determinación del estado actual o nivel de desarrollo de la planificación de Recursos Humanos en los hoteles. Los resultados del presente trabajo han sido importantes para la planificación de recursos humanos de forma eficaz y operativa en los hoteles que integran el sistema turístico de Manabí. Además, las entidades hoteleras de la provincia demandan de una gestión de sus recursos humanos con enfoque integral y sistémico, donde es decisivo el papel que desempeña la Planificación de los recursos humanos, con una transformación tanto de métodos como de pensamiento, para emprender acciones en el logro de mejores resultados y no solo el empleo de la experiencia o intuición de los directivos.

  7. Decoding Melanoma Metastasis

    Energy Technology Data Exchange (ETDEWEB)

    Damsky, William E. Jr. [Department of Dermatology, Yale School of Medicine, New Haven, Connecticut (United States); Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont (United States); Rosenbaum, Lara E.; Bosenberg, Marcus, E-mail: Marcus.Bosenberg@yale.edu [Department of Dermatology, Yale School of Medicine, New Haven, Connecticut (United States)

    2010-12-30

    Metastasis accounts for the vast majority of morbidity and mortality associated with melanoma. Evidence suggests melanoma has a predilection for metastasis to particular organs. Experimental analyses have begun to shed light on the mechanisms regulating melanoma metastasis and organ specificity, but these analyses are complicated by observations of metastatic dormancy and dissemination of melanocytes that are not yet fully malignant. Additionally, tumor extrinsic factors in the microenvironment, both at the site of the primary tumor and the site of metastasis, play important roles in mediating the metastatic process. As metastasis research moves forward, paradigms explaining melanoma metastasis as a step-wise process must also reflect the temporal complexity and heterogeneity in progression of this disease. Genetic drivers of melanoma as well as extrinsic regulators of disease spread, particularly those that mediate metastasis to specific organs, must also be incorporated into newer models of melanoma metastasis.

  8. Primary malignant melanoma

    Directory of Open Access Journals (Sweden)

    A. Ferhat Mısır

    2016-04-01

    Full Text Available Malignant melanomas (MM of the oral cavity are extremely rare, accounting for 0.2% to 8.0% of all malignant melanomas. Malignant melanomas is more frequently seen at the level of the hard palate and gingiva. Early diagnosis and treatment are important for reducing morbidity. Malignant melanoma cells stain positively with antibodies to human melanoma black 45, S-100 protein, and vimentin; therefore, immunohistochemistry can play an important role in evaluating the depth of invasion and the location of metastases. A 76-year-old man developed an oral malignant melanoma, which was originally diagnosed as a bluish reactive denture hyperplasia caused by an ill-fitting lower denture. The tumor was removed surgically, and histopathological examination revealed a nodular-type MM. There was no evidence of recurrence over a 4-year follow-up period.

  9. CASE REPORT: NODULAR MELANOMA

    Directory of Open Access Journals (Sweden)

    Tina Zupančič

    2015-05-01

    Full Text Available Nodular melanoma is a rare type of cutaneous melanoma with an increased risk of death. It often mimics benign cutaneous tumors and inflammatory lesions. It has pronounced vertical growth phase and greater thickness at the time of diagnosis which caries ominous prognostic value. Nodular melanoma quickly develops metastases which are often present before the disease is clinically recognised. Here, we report a case of nodular melanoma clinically mimicking seborrheic keratosis. Therapy and 36 months follow-up after primal excision are also presented.

  10. Derechos Humanos y Derecho Internacional

    Directory of Open Access Journals (Sweden)

    Carrillo Salcedo, Juan Antonio

    2000-09-01

    Full Text Available Not available

    La aparición de un nuevo consenso internacional en torno a las nociones de derechos humanos y democracia, como valores generalmente aceptados por la comunidad de naciones en su conjunto, y la afirmación de que el ser humano es titular de derechos propios, oponibles jurídicamente a todos los Estados, constituyen extraordinarias innovaciones que hacen que, a diferencia del Derecho internacional clásico, la persona no pueda seguir siendo considerada como un mero objeto del Derecho internacional.

  11. Sistema prisional e direitos humanos

    OpenAIRE

    Mendes, André Pacheco Teixeira

    2015-01-01

    O volume 4 da Série Clínicas dos Cadernos FGV DIREITO RIO traz quatro trabalhos originais relacionados ao tema do Sistema Prisional e Direitos Humanos. A obra contempla pareceres jurídicos sobre violações aos direitos dos presos nas unidades prisionais do estado do Rio de Janeiro, tendo por objeto: (i) emprego ilegal de laxante em custodiados e visitantes suspeitos de carregarem drogas; (ii) falta de água própria para o consumo humano; (iii) restrição ao banho de sol; e (iv) condições inadequ...

  12. Emociones, justicia y derechos humanos

    OpenAIRE

    Baum, Erica

    2011-01-01

    En el contexto del mundo globalizado actual, en el que proliferan los movimientos sociales de indignación por las injusticias y el horror, esta tesis presenta una perspectiva en derechos humanos sobre el rol de las emociones en la justicia, especialmente en el fuero criminal, y sobre el limite que establecen a dicha relación los principios éticos de igual valor y dignidad humana, autonomía personal y diversidad cultural, en que se fundan los derechos humanos. Siguiendo la teoría neo-estoica d...

  13. Myasis Miasis en humanos

    Directory of Open Access Journals (Sweden)

    Rafael Valderrama Hernández

    1991-02-01

    ón con larvas de mosca produce diversas manifestaciones según el sitio afectado y puede, Incluso, causar la muerte. No es una enfermedad común en humanos pero se observa con alguna regularidad en Colombia y en otros países neotropicales. Afecta con mayor frecuencia las áreas expuestas de la piel y se presenta raramente en ojos, nariz, senos paranasales, tracto urogenital o recto; en estos casos la Infestación se asocia con traumas previos o secreciones purulentas que atraen a las moscas adultas. La carencia de registros y de bibliografía adecuados no permite evaluar el Impacto real de esta parasitosis. Con la presente revisión se pretende contribuir a su conocimiento.

  14. Staging of cutaneous melanoma

    NARCIS (Netherlands)

    P. Mohr (P.); A.M.M. Eggermont (Alexander); A. Hauschild (Axel); A. Buzaid (A.)

    2009-01-01

    textabstractThe American Joint Committee on Cancer (AJCC) staging of cutaneous melanoma is a continuously evolving system. The identification of increasingly more accurate prognostic factors has led to major changes in melanoma staging over the years, and the current system described in this review

  15. Canine oral melanoma.

    Science.gov (United States)

    Bergman, Philip J

    2007-05-01

    Melanoma is the most common oral malignancy in the dog. Oral and/or mucosal melanoma has been routinely considered an extremely malignant tumor with a high degree of local invasiveness and high metastatic propensity. Primary tumor size has been found to be extremely prognostic. The World Health Organization staging scheme for dogs with oral melanoma is based on size, with stage I = or = 4cm tumor and/or lymph node metastasis, and stage IV = distant metastasis. Median survival times for dogs with oral melanoma treated with surgery are approximately 17 to 18, 5 to 6, and 3 months with stage I, II, and III disease, respectively. Significant negative prognostic factors include stage, size, evidence of metastasis, and a variety of histologic criteria. Standardized treatments such as surgery, coarse-fractionation radiation therapy, and chemotherapy have afforded minimal to modest stage-dependent clinical benefits and death is usually due to systemic metastasis. Numerous immunotherapeutic strategies have been employed to date with limited clinical efficacy; however, the use of xenogeneic DNA vaccines may represent a leap forward in clinical efficacy. Oral melanoma is a spontaneous syngeneic cancer occurring in outbred, immunocompetent dogs and appears to be a more clinically faithful therapeutic model for human melanoma; further use of canine melanoma as a therapeutic model for human melanoma is strongly encouraged. In addition, the development of an expanded but clinically relevant staging system incorporating the aforementioned prognostic factors is also strongly encouraged.

  16. Uveal melanoma: estimating prognosis.

    Science.gov (United States)

    Kaliki, Swathi; Shields, Carol L; Shields, Jerry A

    2015-02-01

    Uveal melanoma is the most common primary malignant tumor of the eye in adults, predominantly found in Caucasians. Local tumor control of uveal melanoma is excellent, yet this malignancy is associated with relatively high mortality secondary to metastasis. Various clinical, histopathological, cytogenetic features and gene expression features help in estimating the prognosis of uveal melanoma. The clinical features associated with poor prognosis in patients with uveal melanoma include older age at presentation, male gender, larger tumor basal diameter and thickness, ciliary body location, diffuse tumor configuration, association with ocular/oculodermal melanocytosis, extraocular tumor extension, and advanced tumor staging by American Joint Committee on Cancer classification. Histopathological features suggestive of poor prognosis include epithelioid cell type, high mitotic activity, higher values of mean diameter of ten largest nucleoli, higher microvascular density, extravascular matrix patterns, tumor-infiltrating lymphocytes, tumor-infiltrating macrophages, higher expression of insulin-like growth factor-1 receptor, and higher expression of human leukocyte antigen Class I and II. Monosomy 3, 1p loss, 6q loss, and 8q and those classified as Class II by gene expression are predictive of poor prognosis of uveal melanoma. In this review, we discuss the prognostic factors of uveal melanoma. A database search was performed on PubMed, using the terms "uvea," "iris," "ciliary body," "choroid," "melanoma," "uveal melanoma" and "prognosis," "metastasis," "genetic testing," "gene expression profiling." Relevant English language articles were extracted, reviewed, and referenced appropriately.

  17. Uveal melanoma: Estimating prognosis

    Directory of Open Access Journals (Sweden)

    Swathi Kaliki

    2015-01-01

    Full Text Available Uveal melanoma is the most common primary malignant tumor of the eye in adults, predominantly found in Caucasians. Local tumor control of uveal melanoma is excellent, yet this malignancy is associated with relatively high mortality secondary to metastasis. Various clinical, histopathological, cytogenetic features and gene expression features help in estimating the prognosis of uveal melanoma. The clinical features associated with poor prognosis in patients with uveal melanoma include older age at presentation, male gender, larger tumor basal diameter and thickness, ciliary body location, diffuse tumor configuration, association with ocular/oculodermal melanocytosis, extraocular tumor extension, and advanced tumor staging by American Joint Committee on Cancer classification. Histopathological features suggestive of poor prognosis include epithelioid cell type, high mitotic activity, higher values of mean diameter of ten largest nucleoli, higher microvascular density, extravascular matrix patterns, tumor-infiltrating lymphocytes, tumor-infiltrating macrophages, higher expression of insulin-like growth factor-1 receptor, and higher expression of human leukocyte antigen Class I and II. Monosomy 3, 1p loss, 6q loss, and 8q and those classified as Class II by gene expression are predictive of poor prognosis of uveal melanoma. In this review, we discuss the prognostic factors of uveal melanoma. A database search was performed on PubMed, using the terms "uvea," "iris," "ciliary body," "choroid," "melanoma," "uveal melanoma" and "prognosis," "metastasis," "genetic testing," "gene expression profiling." Relevant English language articles were extracted, reviewed, and referenced appropriately.

  18. Bronchial malignant melanoma.

    Science.gov (United States)

    Weshler, Z; Sulkes, A; Kopolovitch, J; Leviatan, A; Shifrin, E

    1980-01-01

    We describe a case of malignant melanoma presenting initially as an endobronchial lesion located in the left main bronchus causing total atelectasis. This resolved with radiation therapy. Widespread metastases developed shortly thereafter. The differential diagnosis of primary and metastatic bronchial malignant melanoma is discussed. Other isolated case reports are reviewed.

  19. Melanoma do aparelho ungueal Nail apparatus melanoma

    Directory of Open Access Journals (Sweden)

    Ignez Regina dos Santos Muri Mendonça

    2004-10-01

    Full Text Available O melanoma do aparelho ungueal é apresentação relativamente rara dessa neoplasia, muitas vezes diagnosticada como nevo juncional, hematoma subungueal ou mesmo onicomicose. Esse fato leva a um atraso no diagnóstico e, conseqüentemente, na instituição da terapêutica específica, contribuindo para agravar o prognóstico de uma doença que por si só já é muito agressiva. Os autores relatam um caso de melanoma no primeiro quirodáctilo esquerdo de uma paciente negra com evolução de um ano, ressaltando a importância de avaliar certos critérios clínicos para obter o diagnóstico em fases mais precoces da doença.Nail apparatus melanoma is a rare presentation of melanoma and may be misdiagnosed as junctional nevus, subungual hematoma or onychomycosis. This fact often leads initially to inappropriate treatment and significant delays in appropriately managing such an aggressive disease. The authors report a case of melanoma on the left thumb of a black patient evolving for a year. Emphasis was placed on the importance of assessing certain clinical characteristics in order to reach an early diagnosis.

  20. Melanoma during pregnancy

    DEFF Research Database (Denmark)

    de Haan, Jorine; Lok, Christianne A; de Groot, Christianne J M

    2017-01-01

    The management of melanoma during pregnancy is challenging as maternal benefits and fetal risks need to be balanced. Here, we present an overview of the incidence, the demographic and clinical characteristics and the treatment modalities used. After analysis of obstetric, fetal and maternal outcome......, recommendations for clinical practice are provided. From the 'International Network on Cancer, Infertility and Pregnancy' database, pregnant patients with melanoma were identified and analysed. Sixty pregnancies were eligible for analysis. Fifty percent of the patients presented with advanced melanoma during...... pregnancy (14 stage III and 16 stage IV), and 27% were diagnosed with recurrent melanoma. Surgery was the main therapeutic strategy during pregnancy. Only four patients with advanced melanoma were treated during pregnancy with systemic therapy (n=1) or radiotherapy (n=3). Premature delivery was observed...

  1. Cutaneous manifestations associated with melanoma.

    Science.gov (United States)

    Vyas, Ritva; Selph, Jacqueline; Gerstenblith, Meg R

    2016-06-01

    Melanoma is a malignancy most commonly arising from the skin; therefore, primary melanoma characteristics are usually the first cutaneous manifestations of melanoma. Cutaneous metastases, which can occur locally or diffusely, are important to detect in a timely manner as treatments for advanced melanoma that impact survival are now available. Melanoma can be associated with local or diffuse pigmentation changes, including depigmentation associated with the leukodermas and hyperpigmentation associated with diffuse melanosis cutis. The leukodermas occur frequently, illustrate the immunogenic nature of melanoma, and may impact prognosis. Paraneoplastic syndromes in association with melanoma are rare, though can occur. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Los Derechos Humanos y desaparecidos en dictaduras militares

    Directory of Open Access Journals (Sweden)

    Juan Carlos GUTIÉRREZ CONTRERAS

    2009-11-01

    Full Text Available RESUMEN: La doctrina de la seguridad nacional jugó un papel predominante como soporte ideológico de las dictaduras del Cono Sur americano. Dentro de este marco se adelantó el "Plan Cóndor" que llevó a la múltiple y sistemática violación de derechos humanos en los países en los que se desarrolló. El artículo hace un análisis jurídico de la responsabilidad de los actores a la luz del derecho penal internacional y del derecho internacional de los derechos humanos, con especial énfasis en la competencia para el juzgamiento de los hechos. Concluye con el análisis del terrorismo de Estado manifestado a través del genocidio, la tortura y las desapariciones forzadas cometidos durante las dictaduras militares.ABSTRACT: The doctrine of national secutiry played a leading role as an ideological endorsement of the South American dictatorships. The Plan Condor was created in this context, and it led to systematic and multiple human rights violations. This article analyzes the responsibility of different actors in the light of International Law, and puts special emphasis in the competence of courts to judge those facts. It concludes with an analysis of state terrorísm, which led to genocide, torture and disapperances under military dictatorships.

  3. Derechos humanos y movimientos sociales: experiencia participativa en la universidad

    Directory of Open Access Journals (Sweden)

    Pablo Álvarez Domínguez

    2011-01-01

    Full Text Available Este artículo recoge una serie de una serie de reflexiones teóricas y prácticas, relacionadas con la necesidad de aprender en una sociedad globalizada sobre Derechos Humanos. Reto que ha de ir ligado a un compromiso de acción que debe desarrollarse en cualquiera de las esferas sociales (movimientos, asociaciones, ONG's, etc. que tenemos a nuestro alcance. Asumimos que en el contexto del proceso de enseñanza y aprendizaje en el contexto universitario, el tema de los Derechos Humanos es una asignatura pendiente a la que ha de dar respuesta la Universidad como institución al servicio de la sociedad y promotora del desarrollo de la justicia social. La enseñanza y el aprendizaje de estos derechos no consiste sólo en darlos a conocer, sino en asimilarlos, asumirlos e integrarlos en el proceso formativo personal, posibilitando que las personas sientan responsabilidad por su desarrollo. Para fomentar la participación social es importante motivarlas desde las emociones, para que sean capaces de implicarse en las circunstancias políticas, sociales y culturales de la sociedad civil. En este trabajo, y con el fin de fundamentar empíricamente nuestro planteamiento, describimos el desarrollo de una experiencia universitaria de participación socioeducativa que nos permite valorar el papel de los movimientos sociales en nuestro actual contexto sociocultural.

  4. Guía práctica para la gestión de los recursos humanos

    OpenAIRE

    Bonilla Rubiano, Jorge Mauricio

    2016-01-01

    Con base en la experiencia del autor, se evalúa el papel del área de recursos humanos en las empresas, principalmente en los hoteles. Adicionalmente, se formulan propuestas encaminadas hacia la creación, planeación y gestión de la correspondiente área en el interior de las organizaciones y se proponen instrumentos para su implementación en el nivel operativo.

  5. Guía práctica para la gestión de los recursos humanos

    Directory of Open Access Journals (Sweden)

    Jorge Mauricio Bonilla Rubiano

    2016-06-01

    Full Text Available Con base en la experiencia del autor, se evalúa el papel del área de recursos humanos en las empresas, principalmente en los hoteles. Adicionalmente, se formulan propuestas encaminadas hacia la creación, planeación y gestión de la correspondiente área en el interior de las organizaciones y se proponen instrumentos para su implementación en el nivel operativo.

  6. Call for Papers: Justicia Social y Derechos Humanos: el papel de la sociedad civil

    Directory of Open Access Journals (Sweden)

    2015-10-01

    Full Text Available Editores:  Emilio Martínez Navarro (Universidad de Murcia y Martha Rodríguez Coronel (Universitat Jaume I de CastellónPeriodo de envío artículos y reseñas: finaliza el 15 de enero de 2016Publicación del número: octubre 2016Idiomas: castellano, catalán e inglésInstrucciones para autores: al visitar la página web http://www.e-revistes.uji.es/index.php/recerca encontrarás las normas para publicar y una plantilla para artículos.Más información sobre el número: al228496@uji.esRECERCA es una revista semestral que se publica periódicamente durante los meses de abril y octubre. Es una publicación basada en la revisión ciega por pares del Departamento de Filosofía y Sociología de la universitat Jaume I de Castellón. Recerca pretende atraer artículos de primera calidad científica de investigadores nacionales e internacionales del campo de la filosofía y de la sociología crítica. La revista está indexada en: Humanities Source Publications, Fuente Académica Premier, Philosopher´s Index, ERIH - PLUS, CINDOC (categoría B, e-revist@s y Latindex.

  7. Characterization of melanoma associated spongiform scleropathy

    DEFF Research Database (Denmark)

    Alyahya, Ghassan Ayish Jabur; Heegaard, Steffen; Prause, J.U.

    2002-01-01

    ophthalmology, melanoma associated spongiform scleropathy (MASS), MASS, malignant uveal melanoma, sclera, ciliary body, choroid, histopathology......ophthalmology, melanoma associated spongiform scleropathy (MASS), MASS, malignant uveal melanoma, sclera, ciliary body, choroid, histopathology...

  8. Management of Melanoma Families

    Directory of Open Access Journals (Sweden)

    Wilma Bergman

    2010-04-01

    Full Text Available In this review we have aimed to focus on the clinical management of familial melanoma patients and their relatives. Along this line three major topics will be discussed: (1 management/screening of familial melanoma families: what is advised and what is the evidence thereof; (2 variability of families worldwide with regard to clinical phenotype, including cancer spectrum and likelihood of finding germline mutations and (3 background information for clinicians on the molecular biology of familial melanoma and recent developments in this field.

  9. Naturaleza de los derechos humanos

    Directory of Open Access Journals (Sweden)

    Carlos López Dawson

    2016-07-01

    Full Text Available En la formación de una nueva Carta Fundamental los constituyentes requerirán conocer o consensuar sobre la naturaleza de los derechos humanos; luego, determinar cómo el Estado hará efectivo el respeto de tales derechos. Para ello es necesario recurrir a la historia y evolución de estos derechos, y el presente trabajo trata de contribuir a un debate productivo eficiente sobre la naturaleza de los derechos humanos, para que los ciudadanos puedan decidir en el entendido de que se trata de una decisión democrática reflexionada y fundada en el humanismo. El análisis se sitúa en el contexto técnico-ideológico del sistema republicano vigente que corresponde al estado actual del derecho internacional.

  10. Intravital Microscopy for Identifying Tumor Vessels in Patients With Stage IA-IV Melanoma That is Being Removed by Surgery

    Science.gov (United States)

    2017-06-05

    Recurrent Melanoma; Stage IA Skin Melanoma; Stage IB Skin Melanoma; Stage IIA Skin Melanoma; Stage IIB Skin Melanoma; Stage IIC Skin Melanoma; Stage IIIA Skin Melanoma; Stage IIIB Skin Melanoma; Stage IIIC Skin Melanoma; Stage IV Skin Melanoma

  11. The Danish Melanoma Database

    DEFF Research Database (Denmark)

    Hölmich, Lisbet Rosenkrantz; Klausen, Siri; Spaun, Eva

    2016-01-01

    AIM OF DATABASE: The aim of the database is to monitor and improve the treatment and survival of melanoma patients. STUDY POPULATION: All Danish patients with cutaneous melanoma and in situ melanomas must be registered in the Danish Melanoma Database (DMD). In 2014, 2,525 patients with invasive......-node-metastasis stage. Information about the date of diagnosis, treatment, type of surgery, including safety margins, results of lymphoscintigraphy in patients for whom this was indicated (tumors > T1a), results of sentinel node biopsy, pathological evaluation hereof, and follow-up information, including recurrence......, nature, and treatment hereof is registered. In case of death, the cause and date are included. Currently, all data are entered manually; however, data catchment from the existing registries is planned to be included shortly. DESCRIPTIVE DATA: The DMD is an old research database, but new as a clinical...

  12. Proteomics in uveal melanoma.

    LENUS (Irish Health Repository)

    Ramasamy, Pathma

    2014-01-01

    Uveal melanoma is the most common primary intraocular malignancy in adults, with an incidence of 5-7 per million per year. It is associated with the development of metastasis in about 50% of cases, and 40% of patients with uveal melanoma die of metastatic disease despite successful treatment of the primary tumour. The survival rates at 5, 10 and 15 years are 65%, 50% and 45% respectively. Unlike progress made in many other areas of cancer, uveal melanoma is still poorly understood and survival rates have remained similar over the past 25 years. Recently, advances made in molecular genetics have improved our understanding of this disease and stratification of patients into low risk and high risk for developing metastasis. However, only a limited number of studies have been performed using proteomic methods. This review will give an overview of various proteomic technologies currently employed in life sciences research, and discuss proteomic studies of uveal melanoma.

  13. Primary leptomeningeal melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Aichner, F.; Schuler, G.

    1982-11-01

    A case of primary leptomeningeal melanoma is presented in which the diagnosis was made by ultrastructural demonstration of melanoma cells from the cerebrospinal fluid (CSF) at a time when cranial computed tomography (CT) still gave negative results. Later CT examinations documented the emergence of a tumor mass of the left temporoparietal lobe. This case clearly illustrates the complementary role of these investigational procedures for the diagnosis of cerebrospinal melanoma: leptomeningeal involvement, characterized by two-dimensional diffuse spread of melanoma tissue (''leptomeningeal melanomatosis''), is invisible with CT, but easily recognisable by CSF cytology; in contrast, nodular parenchymal tumor deposits can be readily detected by CT. Identification of pigmented cells recovered from the CSF requires ultrastructural confirmation.

  14. Primary Anorectal Melanoma: An Update

    Directory of Open Access Journals (Sweden)

    P Carcoforo, M.T Raiji, G.M Palini, M Pedriali, U Maestroni, G Soliani, A Detroia, M.V Zanzi, A.L Manna, J.G Crompton, R.C Langan, A Stojadinovic, I Avital

    2012-01-01

    Full Text Available The anorectum is a rare anatomic location for primary melanoma. Mucosal melanoma is a distinct biological and clinical entity from the more common cutaneous melanoma. It portrays worse prognosis than cutaneous melanoma, with distant metastases being the overwhelming cause of morbidity and mortality. Surgery is the treatment of choice, but significant controversy exists over the extent of surgical resection. We present an update on the state of the art of anorectal mucosal melanoma. To illustrate the multimodality approach to anorectal melanoma, we present a typical patient.

  15. Genetics of Melanoma

    Directory of Open Access Journals (Sweden)

    Janet eWangari-Talbot

    2013-01-01

    Full Text Available Genomic variation is a trend observed in various human diseases including cancer. Genetic studies have set out to understand how and why these variations result in cancer, why some populations are predisposed to the disease, and also how genetics affect drug responses. The melanoma incidence has been increasing at an alarming rate worldwide. The burden posed by melanoma has made it a necessity to understand the fundamental signaling pathways involved in this deadly disease. Signaling cascades such as MAPK and PI3K/AKT have been shown to be crucial in the regulation of processes that are commonly dysregulated during cancer development such as aberrant proliferation, loss of cell cycle control, impaired apoptosis and altered drug metabolism. Understanding how these and other oncogenic pathways are regulated has been integral in our challenge to develop potent anti-melanoma drugs. With advances in technology and especially in next generation sequencing, we have been able to explore melanoma genomes and exomes leading to the identification of previously unknown genes with functions in melanomagenesis such as GRIN2A and PREX2. The therapeutic potential of these novel candidate genes is actively being pursued with some presenting as druggable targets while others serve as indicators of therapeutic responses. In addition, the analysis of the mutational signatures of melanoma tumors continues to cement the causative role of UV exposure in melanoma pathogenesis. It has become distinctly clear that melanomas from sun exposed skin areas have distinct mutational signatures including C to T transitions indicative of UV-induced damage. It is thus necessary to continue spreading awareness on how to decrease the risk factors of developing the disease while at the same time working for a cure. Given the large amount of information gained from these sequencing studies, it is likely that in the future, treatment of melanoma will follow a highly personalized route

  16. Perforating metastatic melanoma

    Directory of Open Access Journals (Sweden)

    Takenobu Ohashi

    2015-01-01

    Full Text Available We describe a case of metastatic malignant melanoma on the thigh with comedo-like appearance, which histologically showed elimination of tumor cells. A 70 year-old man was diagnosed with a nodular type malignant melanoma involving the lower back with satellite lesions (stage IIIB, T4b N2c M0, Breslow’s tumor thickness; 10.3 mm, Clark’s level; IV.

  17. Disseminated malignant melanoma

    Directory of Open Access Journals (Sweden)

    Verma Kaushal

    1999-01-01

    Full Text Available A 25-year-old man had multiple asymptomatic, nodular lesions on the trunk, extremities and the face for 3 months. He also had left facial palsy with severe headache and vomiting. There were no other systemic or constitutional symptoms. Skin biopsy from a nodular lesion showed features of malignant melanoma, confirmed by Fontana Masson and S-100 protein staining. A diagnosis of disseminated malignant melanoma was made and the patient was treated symptomatically. The patient died in 4 months.

  18. Prazer e sofrimento no trabalho: representações sociais de profissionais de recursos humanos

    Directory of Open Access Journals (Sweden)

    Roque Tadeu Gui

    Full Text Available Este estudo descreve as representações sociais de profissionais da área de Recursos Humanos do Banco do Brasil sobre prazer e sofrimento no trabalho. A pesquisa tem fundamentação teórica na Psicodinâmica do Trabalho e na Teoria das Representações Sociais. A metodologia adotada é de orientação qualitativa, utilizando-se a técnica do grupo focal como principal meio de coleta dos dados. Os participantes da pesquisa reconhecem a existência de situações que geram prazer e sofrimento no Banco do Brasil e admitem que é papel dos profissionais de Recursos Humanos intervir nas situações de sofrimento, com o objetivo de diminuí-lo e de potencializar as vivências de prazer na Organização.

  19. Radioimmunoscintigraphy in ocular melanoma

    International Nuclear Information System (INIS)

    Kovacs, J.; Chatterton, B.E.; Muecke, J.; Penglis, S.

    1999-01-01

    Full text: Malignant choroidal melanoma is one of the most common primary intraocular neoplasms. Despite significant advances in indirect ophthalmology, ultrasound, computed tomography (CT), magnetic resonance imaging (MRI) and fluoroescein angiography, choroidal melanomas may be difficult to distinguish from other malignant and non-malignant eye lesions. Radioimmunoscintigraphy (RIS) with 99 Tc m -labelled monoclonal antibody F(ab')2 fragments was performed on three patients (2 females, 1 male) who were suspected of having a choroidal melanoma. Patients were injected with 240-420 MBq Technemab-K-1 and scanned 6 and 22 h post-injection. Both planar and single photon emission tomographic (SPET) imaging were performed. RIS was faintly positive in one patient in whom the diagnosis of choroidal melanoma was confirmed by enucleation of the left eye. In the other two patients, immunoscintigraphy was negative. One patient had a benign choroidal haemangioma and the other an amelanotic melanoma. This was confirmed on clinical follow-up. These preliminary results indicate that this procedure may have utility for choroidal melanoma

  20. RECURSOS HUMANOS EN LAS FILOSOFÍAS GERENCIALES Y TENDENCIAS DE LA GESTIÓN DE LOS RECURSOS HUMANOS EN EL MUNDO

    Directory of Open Access Journals (Sweden)

    María Sonia Fleitas Triana

    2002-10-01

    Full Text Available

    El mundo empresarial contemporáneo está caracterizado por tres fuerzas que son determinantes en la definición de las estrategias empresariales: los clientes, la competencia y el cambio. Los recursos humanos constituirán en el siglo XXI el recurso competitivo más importante, pues son determinantes en la materialización de las relaciones con los clientes, constituyen una fuente de ventaja competitiva sustentable y con una adecuada preparación desempeñan un importante papel como agentes de cambio de las organizaciones. Sin embargo, todo lo anterior solo es posible cuando se logra una correcta gestión de dichos recursos. En el articulo se expondrán antecedentes de la actual gestión de recursos humanos, la dimensión humana de la empresa del futuro y los rasgos más significativos de las actuales concepciones de gestión de los recursos humanos.Se presentan modelos de gestión de recursos humanos reconocidos internacionalmente insistiendo en el carácter sistemático de la gestión de los recursos humanos y en la definición de políticas y actividades claves que deben ejecutar los empresarios con vistas a lograr bienestar individual, bienestar social y eficacia en la organización.

  1. Los retos del desarrollo humano en el territorio: experiencias en Brasil y Colombia

    Directory of Open Access Journals (Sweden)

    Sueli de Lourdes Couto Rosa

    2012-01-01

    Full Text Available En este artículo se reflexiona sobre el papel del Estado y el territoriocuando se están abordando procesos de desarrollo humano local. Para esto se analizó el desarrollo, los sustentos teóricos del desarrollo humano local (DHL y la metodología propuesta por el Programa de Naciones Unidas para el Desarrollo para su consecución en lo local. Finalmente, se hace una revisión de los resultados de la aplicación de la metodología de DHL en Colombia y Brasil, lo que permite concluir que el DHL se diferencia de las demás formas de desarrollo por la formación de capital social y humano, por la generación de activos de ciudadanía para las personas involucradas en el proceso. Sin embargo, los grandes desafíos siguen. Sin el imperativo real por el desarrollo humano ysin el compromiso con un desarrollo desde su base territorial,es probable que la mayoría de los proyectos de DHL sean llevados por el mismo camino de los demás modelos de desarrollo.

  2. Quem descobre o melanoma cutâneo Who discovers the cutaneous melanoma

    Directory of Open Access Journals (Sweden)

    Marcus Maia

    2006-06-01

    Full Text Available FUNDAMENTO: No Brasil não se sabe quem descobre os casos de melanoma cutâneo. A compreensão dos "modelos de descoberta" poderia servir de base para os programas de educação pública e do profissional de saúde. OBJETIVO: Determinar o papel dos pacientes em encontrar suas próprias lesões. MÉTODOS: Foram entrevistados 109 pacientes com diagnóstico anterior de melanoma cutâneo, acompanhados na Unidade de Melanoma da Santa Casa de Misericórdia de São Paulo. Outras variáveis foram anotadas para avaliar suas possíveis influências no resultado da descoberta: sexo, idade, estado civil, escolaridade, antecedente familiar de melanoma, localização da lesão primária e conhecimento sobre câncer da pele. RESULTADOS: Dos 109 pacientes, 59 (54% notaram a própria lesão. Deles, 62% eram mulheres, 51% menores de 60 anos, 90% sem antecedentes familiares de melanoma, 78% negavam conhecimento sobre câncer de pele, 59% eram casados, 52% cursaram apenas a escola primária. Os demais 50 pacientes tiveram sua lesão descoberta em 24% dos casos por profissionais de saúde, 10% pela esposa, 1% pelo marido e 11% por outras pessoas. CONCLUSÃO: 54% dos pacientes notaram sua própria lesão, que em cerca de 25% foi descoberta por leigos. Esses resultados são semelhantes aos da literatura dos países desenvolvidos. A clientela avaliada foi do tipo assistencial, e com esse resultado é possível acreditar que, no Brasil, alguma influência das campanhas públicas de saúde já pode ser notada.BACKGROUND - In Brazil, it is still unknown who first discovers the cases of cutaneous melanoma. The understanding of our “finding patterns” could be used as a basis for public education programs and healthcare professional training. OBJECTIVE - To determine the role of patients in detecting lesions by themselves. METHODS - One hundred and nine patients were interviewed. The patients had a diagnosis of cutaneous melanoma and were regularly seen at the Melanoma

  3. The Danish Melanoma Database

    Directory of Open Access Journals (Sweden)

    Hölmich Lr

    2016-10-01

    Full Text Available Lisbet Rosenkrantz Hölmich,1 Siri Klausen,2 Eva Spaun,3 Grethe Schmidt,4 Dorte Gad,5 Inge Marie Svane,6,7 Henrik Schmidt,8 Henrik Frank Lorentzen,9 Else Helene Ibfelt10 1Department of Plastic Surgery, 2Department of Pathology, Herlev-Gentofte Hospital, University of Copenhagen, Herlev, 3Institute of Pathology, Aarhus University Hospital, Aarhus, 4Department of Plastic and Reconstructive Surgery, Breast Surgery and Burns, Rigshospitalet – Glostrup, University of Copenhagen, Copenhagen, 5Department of Plastic Surgery, Odense University Hospital, Odense, 6Center for Cancer Immune Therapy, Department of Hematology, 7Department of Oncology, Herlev-Gentofte Hospital, University of Copenhagen, Herlev, 8Department of Oncology, 9Department of Dermatology, Aarhus University Hospital, Aarhus, 10Registry Support Centre (East – Epidemiology and Biostatistics, Research Centre for Prevention and Health, Glostrup – Rigshospitalet, University of Copenhagen, Glostrup, Denmark Aim of database: The aim of the database is to monitor and improve the treatment and survival of melanoma patients.Study population: All Danish patients with cutaneous melanoma and in situ melanomas must be registered in the Danish Melanoma Database (DMD. In 2014, 2,525 patients with invasive melanoma and 780 with in situ tumors were registered. The coverage is currently 93% compared with the Danish Pathology Register.Main variables: The main variables include demographic, clinical, and pathological characteristics, including Breslow’s tumor thickness, ± ulceration, mitoses, and tumor–node–metastasis stage. Information about the date of diagnosis, treatment, type of surgery, including safety margins, results of lymphoscintigraphy in patients for whom this was indicated (tumors > T1a, results of sentinel node biopsy, pathological evaluation hereof, and follow-up information, including recurrence, nature, and treatment hereof is registered. In case of death, the cause and date

  4. Treatment Options by Stage (Melanoma)

    Science.gov (United States)

    ... Reporting & Auditing Grant Transfer Grant Closeout Contracts & Small Business Training Cancer Training at NCI (Intramural) Funding for ... the skin far away from where it first started. Recurrent Melanoma Recurrent melanoma is cancer that has ...

  5. Intracerebral metastases from ocular melanoma.

    OpenAIRE

    Jones, D. R.; Scobie, I. N.; Sarkies, N. J.

    1988-01-01

    A blind painful eye may harbour an unsuspected malignant melanoma. We report a case of ocular melanoma that presented with confusion owing to direct extension via the optic nerve into the anterior cranial fossa.

  6. TAPIOCA MELANOMA OF THE IRIS

    NARCIS (Netherlands)

    DEKEIZER, RJW; OOSTERHUIS, JA; HOUTMAN, WA; DEWOLFFROUENDAAL, D

    Clinical identification of tapioca melanoma of the iris is important because its medical treatment may differ from that of other malignant iris melanomas. The characteristic iris nodules must be differentiated from granulomatous uveitis, metastases, and Lisch nodules (neurofibromatosis). We will

  7. Advanced Melanoma Facebook Live Event

    Science.gov (United States)

    In case you missed it, watch this recent Facebook Live event about the current state of research and treatment for advanced stage melanoma. To learn more, see our evidence-based information about skin cancer, including melanoma.

  8. Universalidad de los Derechos Humanos

    Directory of Open Access Journals (Sweden)

    Orlando José Cadrazco Salcedo

    2011-07-01

    Full Text Available Resumen:La dimensión universal de los Derechos Humanos ha sido proclamada reiteradamente en el sistema de las Naciones Unidas. Dicha universalidad pretende reflejar y, a su vez, fortalecer el consenso de la comunidad internacional respecto de dichos derechos, sin que ello tenga que suponer, en principio, la imposición de ningún tipo de hegemonía jurídica, política o cultural, en particular la occidental, euro céntrica o atlantista. Sin embargo, ya sabemos que esto no resulta nada fácil ante la diversidad cultural de nuestro mundo. Por ejemplo, a nosotros, los “occidentales”, ahora nos resultan especialmente chocantes las normas -jurídicas o morales- fuertemente discriminatorias contra las mujeresexistentes en la mayoría de las culturas y religiones.Palabras claves:Derechos Humanos, Universalidad, Estados Sociales de Derecho, Positivización, Seres Humanos, Occidente, Organización de Naciones Unidas.Abstract :The universal dimension of human rights has been proclaimed repeatedly in the United Nations system. This universality is intended to reflect and, in turn, strengthen the international community consensus on these rights, without having to assume, in principle, the imposition of hegemony any legal, political or cultural, including Western central euro or Atlanta. However, we know that it is not easy to cultural diversity of our world. For example, we as “Westerners”, now we are particularly shocking and legal rules or moral, highly discriminatory against women exist in most cultures and religions.Key words:Human Rights, Universality, Social State of Law, Positivization, Human Beings, West, United Nations Organization.

  9. El virus del papiloma humano

    OpenAIRE

    Cabrero Díaz, Sara

    2012-01-01

    La infección por el Virus del Papiloma Humano es en nuestros tiempos una de las enfermedades de transmisión sexual más frecuentes y su prevalencia puede alcanzar hasta el 60% en las personas activas sexualmente. Este trabajo prentende recopilar datos sobre la enfermedad para comprender el por qué de su transmisión (causas), cómo se manifiesta (síntomas), complicaciones que éste puede producir, técnicas que se usan para su diagnóstico, el posible tratamiento y la controversia que éste ha ca...

  10. Creencias y virus papiloma humano

    OpenAIRE

    Concha P,Ximena; Urrutia S,Teresa; Riquelme H,Giselle

    2012-01-01

    Antecedentes: La infección por Virus Papiloma Humano (VPH) es una enfermedad de transmisión sexual, que afecta a un alto porcentaje de mujeres jóvenes de todo el mundo. Su alta incidencia está asociada al inicio precoz y mayor frecuencia de la actividad sexual. A pesar de que la infección por VPH está ampliamente difundida en el mundo, es una infección aún desconocida por la población, lo que asociado a diversos factores culturales, favorece el desarrollo de múltiples creencias que dificultan...

  11. ORAL AMELANOTIC MELANOMA FEATURE ARTICLE

    African Journals Online (AJOL)

    hard palate (more than 40%) and the gingiva2. Melanomas arise from the uninhibited proliferation ... Malignant melanomas of the mucosal regions of the head and neck are extremely rare neoplasms accounting for less than 1% of .... head and neck region reported that amelanotic melanomas had a 20% survival at 3 years, ...

  12. Genetic Abnormalities in Uveal Melanoma

    NARCIS (Netherlands)

    N.C. Naus (Nicole)

    2001-01-01

    textabstractMelanocytic tumours are believed to arise from the neural crest-derived melanocytes. Five to twelve percent of all melanomas are located in the eye, making it, after the skin, the second most common site of melanomas (Egan et al., 1988; Chang et al., 1998). Uveal melanoma is the most

  13. Targeted Therapy for Melanoma

    International Nuclear Information System (INIS)

    Quinn, Thomas; Moore, Herbert

    2016-01-01

    The research project, entitled ''Targeted Therapy for Melanoma,'' was focused on investigating the use of kidney protection measures to lower the non-specific kidney uptake of the radiolabeled Pb-DOTA-ReCCMSH peptide. Previous published work demonstrated that the kidney exhibited the highest non-target tissue uptake of the 212Pb/203 Pb radiolabeled melanoma targeting peptide DOTA-ReCCMSH. The radiolabeled alpha-melanocyte stimulating hormone (α-MSH) peptide analog DOTA-Re(Arg 11 )CCMSH, which binds the melanocortin-1 receptor over-expressed on melanoma tumor cells, has shown promise as a PRRT agent in pre-clinical studies. High tumor uptake of 212 Pb labeled DOTA-Re(Arg 11 )CCMSH resulted in tumor reduction or eradication in melanoma therapy studies. Of particular note was the 20-50% cure rate observed when melanoma mice were treated with alpha particle emitter 212 Pb. However, as with most PRRT agents, high radiation doses to the kidneys where observed. To optimize tumor treatment efficacy and reduce nephrotoxicity, the tumor to kidney uptake ratio must be improved. Strategies to reduce kidney retention of the radiolabeled peptide, while not effecting tumor uptake and retention, can be broken into several categories including modification of the targeting peptide sequence and reducing proximal tubule reabsorption.

  14. Targeted Therapy for Melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Quinn, Thomas [Alphamed, Jackson, TN (United States); Moore, Herbert [Alphamed, Jackson, TN (United States)

    2016-12-05

    The research project, entitled ”Targeted Therapy for Melanoma,” was focused on investigating the use of kidney protection measures to lower the non-specific kidney uptake of the radiolabeled Pb-DOTA-ReCCMSH peptide. Previous published work demonstrated that the kidney exhibited the highest non-target tissue uptake of the 212Pb/203Pb radiolabeled melanoma targeting peptide DOTA-ReCCMSH. The radiolabeled alpha-melanocyte stimulating hormone (α-MSH) peptide analog DOTA-Re(Arg11)CCMSH, which binds the melanocortin-1 receptor over-expressed on melanoma tumor cells, has shown promise as a PRRT agent in pre-clinical studies. High tumor uptake of 212Pb labeled DOTA-Re(Arg11)CCMSH resulted in tumor reduction or eradication in melanoma therapy studies. Of particular note was the 20-50% cure rate observed when melanoma mice were treated with alpha particle emitter 212Pb. However, as with most PRRT agents, high radiation doses to the kidneys where observed. To optimize tumor treatment efficacy and reduce nephrotoxicity, the tumor to kidney uptake ratio must be improved. Strategies to reduce kidney retention of the radiolabeled peptide, while not effecting tumor uptake and retention, can be broken into several categories including modification of the targeting peptide sequence and reducing proximal tubule reabsorption.

  15. Chemoprevention of Melanoma

    Science.gov (United States)

    Madhunapantula, SubbaRao V.; Robertson, Gavin P.

    2013-01-01

    Despite advances in drug discovery programs and molecular approaches for identifying the drug targets, incidence and mortality rates due to melanoma continues to rise at an alarming rate. Existing preventive strategies generally involve mole screening followed by surgical removal of the benign nevi and abnormal moles. However, due to lack of effective programs for screening and disease recurrence after surgical resection there is a need for better chemopreventive agents. Although sunscreens have been used extensively for protecting from UV-induced skin cancer, results of correlative population based studies are controversial, requiring further authentication to conclusively confirm the chemoprotective efficacy of sunscreens. Certain studies suggest increased skin-cancer rates in sunscreen users. Therefore, effective chemopreventive agents for preventing melanoma are urgently required. This book-chapter, reviews the current understanding regarding melanoma chemoprevention and the various strategies used to accomplish this objective. PMID:22959032

  16. The Immunology of Melanoma.

    Science.gov (United States)

    Ko, Jennifer S

    2017-09-01

    The relatively high DNA mutational burden in melanoma allows for the creation of potentially "foreign," immune-stimulating neoantigens, and leads to its exceptional immunogenicity. Brisk tumor-infiltrating lymphocytes, a marker of immune editing, confer improved overall survival in melanoma, possibly due to reduced sentinel lymph node spread. Meanwhile, T-cell-stimulating drugs, so-called T-cell checkpoint inhibitors, which reverse peripheral tolerance-dependent tumor escape, have demonstrated unparalleled clinical success in metastatic melanoma. Markers to predict response to immunotherapy are currently imperfect, and the subject of intense research, which will guide the future of ancillary pathologic testing in this setting. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. O capital humano e o desenvolvimento econômico

    Directory of Open Access Journals (Sweden)

    Beatriz Maria Witkowski

    2007-07-01

    Full Text Available Um ambiente competitivo de negócios é decorrência cada vez maior de uma administração eficaz do capital humano. Estrutura, tecnologia, recursos financeiros e materiais são aspectos meramente físicos e inertes que precisam ser administrados inteligentemente por meio das pessoas que constituem a organização. A Teoria do Capital Humano é uma derivação da Teoria Econômica Neoclássica e, ao mesmo tempo, uma atualização, do axioma liberal do indivíduo livre, soberano e racional. Ressurgiu com a crise do modelo tayloris ta-fordis ta, associada à redefinição das relações de trabalho na empresa e do papel do sistema educacional. A qualidade dos funcionários de uma organização, seus conhecimentos e habilidades, entusiasmo e satisfação com seus cargos, seu senso de iniciativa para gerar riqueza, tudo isso tem forte impacto na produtividade da organização, no nível de serviço ao cliente, na reputação e na competitividade. Para qualquer que seja a área empresarial escolhida, o futuro administrador necessita ter uma visão sobre como lidar com assuntos relacionados com pessoas para alcançar o seu sucesso profissional e levar a sua organização rumo à excelência e à competitividade. Em seu conjunto, as pessoas constituem o capital humano da organização. Esse capital pode valer mais ou valer menos, na medida em que contenha talentos capazes de agregar valor à organização e torná-la mais ágil e competitiva. Portanto, esse capital vale mais na medida em que consiga influenciar as ações e os destinos da organização. A era da informação torna o trabalho menos físico e mais mental, pois as pessoas deixaram de ser fornecedoras de mão-de-obra para serem alçadas à categoria de fornecedoras de conhecimento e de competências. Do mesmo modo que o capital humano é relevante para a sociedade e para as organizações, observa-se que o desenvolvimento econômico também possui um papel de suma importância. Define

  18. Angiogenesis and Melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Ribatti, Domenico, E-mail: ribatti@anatomia.uniba.it; Annese, Tiziana; Longo, Vito [Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G. Cesare, 11, Policlinico 70124, Bari (Italy)

    2010-02-25

    Angiogenesis occurs in pathological conditions, such as tumors, where a specific critical point in tumor progression is the transition from the avascular to the vascular phase. Tumor angiogenesis depends mainly on the release by neoplastic cells of growth factors specific for endothelial cells, which are able to stimulate the growth of the host’s blood vessels. This article summarizes the literature concerning the relationship between angiogenesis and human melanoma progression. The recent applications of antiangiogenic agents which interfere with melanoma progression are also described.

  19. Imbibición en papel

    OpenAIRE

    Abraham Medina; José Antonio Córdova; Raymundo Martínez

    1999-01-01

    Se estudió un grupo de patrones experimentales durante el proceso de imbibición. A partir del registro de dichos patrones y la digitalización de cuadros elegidos, se midieron los frentes de la imbibición (límites entre las zonas secas y húmedas) en papel multiforme. Se obtuvo una concordancia -para una tira vertical de papel- entre el presente experimento y la Ley Washburn; sin embargo, esta ley no es universal y depende de la geometría.

  20. Melanoma Risk Prediction Models

    Science.gov (United States)

    Developing statistical models that estimate the probability of developing melanoma cancer over a defined period of time will help clinicians identify individuals at higher risk of specific cancers, allowing for earlier or more frequent screening and counseling of behavioral changes to decrease risk.

  1. Congenital uveal melanoma?

    Science.gov (United States)

    Singh, Arun D; Schoenfield, Lynn A; Bastian, Boris C; Aziz, Hassan A; Marino, Meghan J; Biscotti, Charles V

    2016-01-01

    A 3-month-old infant with a white mother and Asian father presented with discoloration and prominence of the left eye since birth. Examination revealed a normal right eye. The left eye had hyperchromic heterochromia and an enlarged cornea (diameter, 13.0 mm) with intraocular pressure of 26 mm Hg. There were multiple areas of subconjunctival nodular pigmentation that extended posteriorly into the superior fornix. Fundus examination showed a large ciliochoroidal pigmented mass extending from 10:30 to 3:00 o'clock position involving the superior half of the choroid and adjacent ciliary body. The eye was enucleated, confirming the diagnosis of diffuse uveal melanoma with extraocular extension. Systemic surveillance (hepatic panel and ultrasonography of the liver) performed every 6 months for 5 years was has been negative for metastases. The tumor was investigated intensively for the panel of genes (BAP1, BRAF, NRAS12, NRAS61, GNAQ, Kit 9,11,13,17,18) implicated in pathogenesis of blue nevus, cutaneous melanoma, and mucosal melanomas with negative results. Moreover, germline BAP1 mutation could not be identified. This case possibly represents as yet unidentified uveal melanocytic proliferation rather than a true variant of uveal melanoma. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Interleukin-6 and melanoma

    DEFF Research Database (Denmark)

    Hoejberg, Lise; Bastholt, Lars; Schmidt, Henrik

    2012-01-01

    Interleukin-6 (IL-6) is a pleiotropic immunomodulatory cytokine produced by various types of cells, including melanoma cells. IL-6 plays a major role in the pathogenesis and development of malignancies. It promotes tumour growth by inhibition of apoptosis and induces tumour angiogenesis. IL-6...

  3. Melanoma risk prediction models

    Directory of Open Access Journals (Sweden)

    Nikolić Jelena

    2014-01-01

    Full Text Available Background/Aim. The lack of effective therapy for advanced stages of melanoma emphasizes the importance of preventive measures and screenings of population at risk. Identifying individuals at high risk should allow targeted screenings and follow-up involving those who would benefit most. The aim of this study was to identify most significant factors for melanoma prediction in our population and to create prognostic models for identification and differentiation of individuals at risk. Methods. This case-control study included 697 participants (341 patients and 356 controls that underwent extensive interview and skin examination in order to check risk factors for melanoma. Pairwise univariate statistical comparison was used for the coarse selection of the most significant risk factors. These factors were fed into logistic regression (LR and alternating decision trees (ADT prognostic models that were assessed for their usefulness in identification of patients at risk to develop melanoma. Validation of the LR model was done by Hosmer and Lemeshow test, whereas the ADT was validated by 10-fold cross-validation. The achieved sensitivity, specificity, accuracy and AUC for both models were calculated. The melanoma risk score (MRS based on the outcome of the LR model was presented. Results. The LR model showed that the following risk factors were associated with melanoma: sunbeds (OR = 4.018; 95% CI 1.724- 9.366 for those that sometimes used sunbeds, solar damage of the skin (OR = 8.274; 95% CI 2.661-25.730 for those with severe solar damage, hair color (OR = 3.222; 95% CI 1.984-5.231 for light brown/blond hair, the number of common naevi (over 100 naevi had OR = 3.57; 95% CI 1.427-8.931, the number of dysplastic naevi (from 1 to 10 dysplastic naevi OR was 2.672; 95% CI 1.572-4.540; for more than 10 naevi OR was 6.487; 95%; CI 1.993-21.119, Fitzpatricks phototype and the presence of congenital naevi. Red hair, phototype I and large congenital naevi were

  4. La alfabetización informacional como derecho humano

    Directory of Open Access Journals (Sweden)

    Paul Sturges

    2012-03-01

    Full Text Available Se puede argumentar que existe una relación entre el derecho a la libertad intelectual (argumento pasivo propuesto por el Artículo 19 de la Declaración Universal sobre los Derechos Humanos de las Naciones Unidas y la consecuente responsabilidad por parte de los gobiernos, los profesionales y los defensores de los derechos civiles de crear (argumento activo las condiciones idóneas para el ejercicio eficaz de la libertad intelectual. Cada vez más los analistas del papel de los medios de comunicación en la sociedad y de la responsabilidad social de la informática también están llegando a conclusiones de este tipo, resaltando la importancia tanto de la alfabetización mediática como de la alfabetización en informática. Obviamente, este argumento nos lleva a analizar el planteamiento que los profesionales de la información se hacen de los cursos sobre alfabetización de información que actualmente imparten. Aunque existen muchos programas de alfabetización informacional que son muy completos, éstos, hasta ahora, se basan, en su mayor parte, en lo que los profesionales piensan que son las necesidades prácticas de los usuarios. Sin embargo, se puede interpretar que las declaraciones de tipo general como, por ejemplo, la Declaración de Praga “Hacia una Sociedad de la Alfabetización Informacional” del 2003 y la Proclamación de Alejandría del 2005 empiezan a apuntar hacia una justificación de las actividades de la alfabetización informacional basadas en los derechos humanos, en concreto en el artículo 19. El argumento es que si se parte de una perspectiva basada en los derechos humanos podemos llegar a una interpretación sólida de la alfabetización informacional que incluya la alfabetización mediática, la alfabetización en informática, la alfabetización en la web y, hasta cierto punto, la alfabetización cívica, desarrollando de este modo un modelo que responde a las necesidades humanas más que a las prioridades

  5. RARE METASTASES OF MALIGNANT MELANOMA

    Directory of Open Access Journals (Sweden)

    Marija Trenkić-Božinović

    2014-09-01

    Full Text Available Melanomas are malignant neoplasms that originate from melanocytes. The most common are on the skin and mucous membranes. Choroidal melanomas are quite different from cutaneous melanomas with regard to presentation, metastases, and treatment. We report two cases of metastatic gastric malignant melanoma of the eye and skin, with reference to the literature. The first patient was a woman aged 23 years, who underwent gastrectomy 22 months after enucleation of the eye due to malignant choroid melanoma. The second patient was a man, 72 years old, who underwent surgery 28 months before because of malignant melanoma of the skin of the forehead. Paraffin sections, 4 μm thick were stained using a classic method, as well as immunohistochemical DAKO APAAP method, using a specific S - 100 antibody and Melan A antibodies. The stomach is considered a rare place for the development of metastases. Metastases in the stomach are often limited to the submucosal as well as the serousmuscular layer, as noted in one of our patients. Metastatic melanoma of the gastrointestinal tract should be suspected in any patient with a history of malignant melanoma and new gastrointestinal symptoms. Because of the similarity between certain common histopathological types of malignant melanoma, primarily achromatic, and types of primary cancers of the stomach, the following immunohistochemical studies are needed: Melan A and S - 100 protein ( markers of malignant melanoma , as well as mucins: MUC5AC, MUC2 and CDX2 ( markers of different types of primary gastric carcinoma.

  6. Prevalencia de la infección por papilomavirus humano en una población de baja incidencia de cancer de cuello uterino

    OpenAIRE

    Múgica van Herckenrode, Carmen

    2014-01-01

    182 p. SE HA INVESTIGADO LA PREVALENCIA DE LA INFECCION POR PAPILOMAVIRUS HUMANO (HPU) EN MUESTRAS DE CUELLO UTERINO DE MUJERES DE UNA POBLACION DE BAJA INCIDENCIA DE CANCER DE CERVIX, MEDIANTE TECNICAS DE DETECCION GENICA (HIBRIDACION DE DNA CON EL METODO DE SLOT-BLOT Y PCR) CON EL OBJETIVO DE DETERMINAR EL PAPEL DEL VIRUS EN EL PROCESO ONCOGENICO DEL CERVIX. SE HA VALORADO, ADEMAS, LA UTILIDAD DE LOS MARCADORES MOLECULARES Y CITOLOGICOS DE LA INFECCION POR HPV PAR...

  7. Communication about melanoma and risk reduction after melanoma diagnosis.

    Science.gov (United States)

    Rodríguez, Vivian M; Berwick, Marianne; Hay, Jennifer L

    2017-12-01

    Melanoma patients are advised to perform regular risk-reduction practices, including sun protection as well as skin self-examinations (SSEs) and physician-led examinations. Melanoma-specific communication regarding family risk and screening may promote such behaviors. To this end, associations between patients' melanoma-specific communication and risk reduction were examined. Melanoma patients (N = 169) drawn from a population-based cancer registry reported their current risk-reduction practices, perceived risk of future melanoma, and communication with physicians and relatives about melanoma risk and screening. Patients were, on average, 56 years old and 6.7 years' post diagnosis; 51% were male, 93% reported "fair/very fair" skin color, 75% completed at least some college, and 22% reported a family history of melanoma. Patients reported varying levels of regular (always/nearly always) sun protection: sunscreen use (79%), shade seeking (60%), hat use (54%), and long-sleeve shirt use (30%). Only 28% performed thorough SSE regularly, whereas 92% reported undergoing physician-led skin examinations within the past year. Participants who were female, younger, and had a higher perceived risk of future melanoma were more likely to report past communication. In adjusted analyses, communication remained uniquely associated with increased sunscreen use and SSE. Encouraging melanoma patients to have a more active role in discussions concerning melanoma risk and screening with relatives and physicians alike may be a useful strategy to promote 2 key risk-reduction practices post melanoma diagnosis and treatment. Future research is needed to identify additional strategies to improve comprehensive risk reduction in long-term melanoma patients. Copyright © 2016 John Wiley & Sons, Ltd.

  8. El papel del lenguaje en las estrategias discursivas para fomentar la enseñanza-aprendizaje

    Directory of Open Access Journals (Sweden)

    LUIS FERNANDO NIETO RUIZ

    2011-01-01

    Full Text Available Mediante estos breves acápites se hace una reflexión en torno del lenguaje y su papel en la formación del ser humano en valores, principios, conocimientos y relaciones interpersonales. Es aquí en donde la educación relacionada con el oficio del maestro se debe centrar en la propalación de las competencias como la propositiva, la interpretativa y la argumentativa; además de esto, que contribuya con la formación de un ser con sentimientos y valores, para que se respete a sí mismo y, por tanto, a los demás, que tenga la capacidad de pensar y reflexionar sobre los diferentes problemas de su entorno. Todo lo anterior se logra mediante la puesta en escena de las estrategias discursivas basadas en la argumentación.

  9. Melanoma Epidemiology and Public Health

    Science.gov (United States)

    Berwick, Marianne; Erdei, Esther; Hay, Jennifer

    2013-01-01

    Melanoma has presented a conundrum to physicians and prevention researchers. We should be able to reduce incidence and mortality rather easily because evolving melanoma lesions are observable on the surface of the skin. However, melanoma has not proved tractable. The incidence and mortality have risen in all developed countries during the past 50 years. However, mortality appears to be abating among younger cohorts even though the reason for this is not clear. PMID:19254665

  10. Melanoma and immunotherapy bridge 2015

    OpenAIRE

    Nanda, Vashisht G. Y.; Peng, Weiyi; Hwu, Patrick; Davies, Michael A.; Ciliberto, Gennaro; Fattore, Luigi; Malpicci, Debora; Aurisicchio, Luigi; Ascierto, Paolo Antonio; Croce, Carlo M.; Mancini, Rita; Spranger, Stefani; Gajewski, Thomas F.; Wang, Yangyang; Ferrone, Soldano

    2016-01-01

    Table of contents MELANOMA BRIDGE 2015 KEYNOTE SPEAKER PRESENTATIONS Molecular and immuno-advances K1 Immunologic and metabolic consequences of PI3K/AKT/mTOR activation in melanoma Vashisht G. Y. Nanda, Weiyi Peng, Patrick Hwu, Michael A. Davies K2 Non-mutational adaptive changes in melanoma cells exposed to BRAF and MEK inhibitors help the establishment of drug resistance Gennaro Ciliberto, Luigi Fattore, Debora Malpicci, Luigi Aurisicchio, Paolo Antonio Ascierto, Carlo M. Croce, Rita Mancin...

  11. Interacciones humano-animal: características e implicaciones para el bienestar de los humanos

    OpenAIRE

    Natalia Piar; Diana Granados; Germán Gutiérrez

    2007-01-01

    En este artículo se revisa la literatura reciente sobre interacciones humano-animal, su origen, sus características y cómo dichas interacciones afectan el bienestar físico, psicológico y social. En la primera parte se presentan los orígenes y evolución histórica de las relaciones humano - animal, empezando por los procesos de domesticación y se aborda la naturaleza de las interacciones humano animal. En la segunda parte, se revisan los efectos para los humanos de ...

  12. Papel do Fator de Crescimento Endotelial Vascular nos Carcinomas de Tireóide

    Directory of Open Access Journals (Sweden)

    Clarissa Capp

    2009-04-01

    Full Text Available O crescimento tumoral está diretamente relacionado com a neovascularização, a qual decorre do desequilíbrio entre os fatores pró-angiogênicos e antiangiogênicos, secretados pelas células neoplásicas O fator de crescimento endotelial vascular (VEGF desempenha papel chave na angiogênese tumoral, estimulando a proliferação, migração e sobrevivência das células endoteliais. Atua através da ligação a receptores tirosina quinase específicos: VEGFR-1/Flt-1, VEGFR-2/KDR e VEGFR-3. O aumento da expressão do VEGF e de seus receptores tem sido associado à progressão, metastatização e pior prognóstico em diversos tumores malignos. A compreensão das vias moleculares que envolvem o mecanismo de indução da angiogênese tumoral por fatores de crescimento como o VEGF aumentam as possibilidades de novas terapêuticas a serem utilizadas no tratamento de tumores malignos humanos. Evidências indicam um importante papel do VEGF nas neoplasias da tireóide e a utilização de inibidores do VEGF ou de seus receptores pode constituir um importante recurso terapêutico, já tendo sido utilizado em determinados tipos de tumores humanos. O presente artigo tem como objetivo fazer uma revisão da atuação do VEGF no crescimento tumoral com enfoque nas neoplasias malignas da tireóide.

  13. Estudio de Recursos Humanos del Sector Salud en Colombia.

    Directory of Open Access Journals (Sweden)

    Gustavo Malagón Londoño

    1997-12-01

    Full Text Available

    Antecedentes


    Siendo el recurso humano el en cargado de movilizar los demás recursos e impulsarlos de tal manera que conlleve a una dinámica de producción masiva de bienes o servicios, su estudio para llegar a una identificación real, categorización, clasificación; es necesario en cualquier área del conocimiento.

    Frente al nuevo esquema de prestación de servicios propuestos, los profesionales de la salud han perdido aquella posición digna, de respeto y liderazgo dentro del sistema y dentro de su entorno social, lo cual ha llevado a muchos de ellos a desertar de sus oficios originales, con lo cual se llega a la falla en la instauración del Sistema.

    Así mismo la Ley 100 de 1993 que debió ser vista como una nueva oportunidad de negocios dentro de las diferentes profesiones de la salud, se transformó en una seria amenaza para el ejercicio independiente de cada profesión.

    No es apropiado ni satisfactorio dejar un proceso decisorio de tal magnitud en manos de otros sectores que únicamente verán y obtendrán estadísticas del acceso de la población colombiana a estudios superiores y los renglones en los cuales quieren desempeñarse y se desempeñarán en un futuro. El sector de la salud debe tomar un claro papel protagónico frente a la promulgación de políticas de formación y utilización de su recurso humano.

    La Academia Nacional de Medicina consciente del vacío existente en el sector con respecto al tema, ha querido desde su posición estratégica con respecto a las profesiones del área y las universidades, liderar un proceso que conlleve a la organización de un Estudio del recurso humano del Sector Salud en Colombia, tomando como punto de partida el censo de los trabajadores de la salud en todas las áreas, de tal manera que se identifique su disponibilidad, su capacidad, la ubicación, las facilidades laborales en zonas aisladas y su grado de satisfacción, entre otras

  14. Nodular amelanotic melanoma

    Directory of Open Access Journals (Sweden)

    Nalamwar Rashmi

    2010-01-01

    Full Text Available We report a case of 65-year-old male patient who presented with multiple erythematous papules coalescing to form a nodular mass over posterior aspect of right thigh of six months duration. His general and systemic examinations were within normal range except for right inguinal lymphadenopathy. Biopsy from the lesion was done, which showed diffuse infiltrate of nests of atypical melanocytes extending upto reticular dermis. Malignant cells were positive for S100 and human melanin black 45(HMB 45. Hence, a diagnosis of amelanotic melanoma (AM - Clarke level IV and TNM stage III was reached. MRI of involved leg showed fungating soft tissue mass in the posterolateral aspect of right thigh and metastatic right inguinal adenopathy. Fine needle aspiration cytology (FNAC from the right inguinal nodes confirmed metastasis of melanoma. The patient was referred to oncosurgery department for further management.

  15. Dermoscopy of difficult-to-diagnose Melanomas

    Directory of Open Access Journals (Sweden)

    Papageorgiou Chrysoula

    2016-09-01

    Full Text Available Dermoscopy is a non-invasive procedure that allows the evaluation of cutaneous lesions, and is considered to be a useful tool that improves the diagnostic accuracy of melanoma. Many dermoscopic criteria of melanoma have been established and several algorithms have been created for melanoma detection. However, the recognition of some melanomas remains challenging. Melanomas on specific body sites, melanomas in patients with multiple atypical moles, and nodular melanomas represent the most difficult-to-recognize melanoma subtypes, since they typically lack the “classic” melanoma-specific criteria. This paper provides an update on dermoscopy of difficult-to-diagnose melanomas by summarizing the newest data. Lastly, we highlight the importance of digital dermoscopy in the follow-up of melanocytic lesions for the detection of incipient melanomas while maintaining a low excision rate.

  16. A relação entre instituições, fatores humanos e segurança operacional na aviação = The relationship between institutions, human factors and operational safety in aviation

    Directory of Open Access Journals (Sweden)

    Villas-Bôas, Paulo Cezar Rodrigues

    2014-01-01

    Full Text Available Este trabalho pretende enfatizar a relação entre organização e indivíduo, ou seja, o papel da cultura organizacional na implementação dos fatores humanos no cotidiano operacional de uma empresa aérea e a influência deste processo no grau de segurança operacional. Objetiva, de forma concisa, apresentar parte do conjunto de conceitos que formam os fatores humanos em aviação, incluindo, a doutrina CRM. Cultura organizacional, processos psicossociais e tecnologia embarcada são correlacionados de forma processual, evidenciando a perspectiva sistêmica dos fatores humanos em aviação. A conclusão mais relevante recai na importância do comprometimento institucional com fatores humanos, influenciando positivamente o grau de segurança operacional das organizações

  17. Los recursos humanos en salud según el nuevo modelo de atención en Ecuador

    Directory of Open Access Journals (Sweden)

    Verónica Espinosa

    2017-06-01

    Full Text Available RESUMEN Objetivo Describir las estrategias implementadas por el Ministerio de Salud Pública del Ecuador (MSP para fortalecer la rectoría de los recursos humanos en salud y responder al nuevo modelo de atención, como parte del proceso de reforma durante el periodo 2012–2015. Métodos Se realizó una revisión documental sobre el desarrollo del recurso humano en salud antes y después de la reforma recabando información en fuentes primarias y secundarias. Resultados En el periodo de estudio, Ecuador generó un nuevo marco institucional y normativo para desarrollar recursos humanos en salud a fin de responder a los requisitos de un modelo de atención basado en la Atención Primaria en Salud (APS. El MSP consolidó su papel rector estableciendo alianzas estratégicas, aplicando métodos de planificación de los recursos humanos y realizando una inversión sin precedentes en la formación del personal sanitario, contrataciones e incrementos salariales. Estos elementos constituyen los ejes iniciales para la construcción de una política de recursos humanos en salud y una carrera sanitaria coherentes con los objetivos de la reforma. Conclusiones En el marco de la reforma realizada entre 2012 y 2015, el desarrollo del recurso humano en salud muestra logros importantes gracias al trabajo intersectorial realizado por el MSP. Entre dichos logros destacan el fortalecimiento de la rectoría, el desarrollo e implementación de normativa e instrumentos regulatorios, la creación de nuevos perfiles de profesionales, y el contrato de profesionales con el objetivo de implementar el Modelo de atención integral de salud (MAIS, lo cual contribuyó a resolver problemas arrastrados durante los años previos a la reforma.

  18. Circulating melanoma cells and survival in metastatic melanoma

    NARCIS (Netherlands)

    Rao, C.; Bui, T.; Connelly, M.; Doyle, G.; Karydis, I.; Middleton, M. R.; Clack, G.; Malone, M.; Coumans, F. A. W.; Terstappen, L. W. M. M.

    2011-01-01

    A validated assay for the enumeration of circulating melanoma cells (CMCs) may facilitate the development of more effective therapies for metastatic melanoma patients. In this study CD146(+) cells were immunomagnetically enriched from 7.5 ml of blood. Isolated cells were fluorescently stained with

  19. ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma

    International Nuclear Information System (INIS)

    Ungerer, Christopher; Doberstein, Kai; Buerger, Claudia; Hardt, Katja; Boehncke, Wolf-Henning; Boehm, Beate; Pfeilschifter, Josef; Dummer, Reinhard; Mihic-Probst, Daniela; Gutwein, Paul

    2010-01-01

    Research highlights: → Strong ADAM15 expression is found in normal melanocytes. → ADAM15 expression is significantly downregulated in patients with melanoma metastasis. → TGF-β can downregulate ADAM15 expression in melanoma cells. → Overexpression of ADAM15 in melanoma cells inhibits migration, proliferation and invasion of melanoma cells. → Conclusion: ADAM15 represents an tumor suppressor protein in melanoma. -- Abstract: In a mouse melanoma metastasis model it has been recently shown that ADAM15 overexpression in melanoma cells significantly reduced the number of metastatic nodules on the lung. Unfortunately, the expression of ADAM15 in human melanoma tissue has not been determined so far. In our study, we characterized the expression of ADAM15 in tissue micro-arrays of patients with primary melanoma with melanoma metastasis. ADAM15 was expressed in melanocytes and endothelial cells of benign nevi and melanoma tissue. Importantly, ADAM15 was significantly downregulated in melanoma metastasis compared to primary melanoma. We further demonstrate that IFN-γ and TGF-β downregulate ADAM15 protein levels in melanoma cells. To investigate the role of ADAM15 in melanoma progression, we overexpressed ADAM15 in melanoma cells. Importantly, overexpression of ADAM15 in melanoma cells reduced the migration, invasion and the anchorage dependent and independent cell growth of melanoma cells. In summary, the downregulation of ADAM15 plays an important role in melanoma progression and ADAM15 act as a tumorsuppressor in melanoma.

  20. ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Ungerer, Christopher; Doberstein, Kai [Pharmazentrum Frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt am Main (Germany); Buerger, Claudia; Hardt, Katja; Boehncke, Wolf-Henning [Department of Dermatology, Clinic of the Goethe-University, Theodor-Stern-Kai, Frankfurt (Germany); Boehm, Beate [Division of Rheumatology, Goethe University, Frankfurt am Main (Germany); Pfeilschifter, Josef [Pharmazentrum Frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt am Main (Germany); Dummer, Reinhard [Department of Pathology, Institute of Surgical Pathology, University Hospital, Zurich (Switzerland); Mihic-Probst, Daniela [Department of Dermatology, University Hospital Zurich (Switzerland); Gutwein, Paul, E-mail: p.gutwein@med.uni-frankfurt.de [Pharmazentrum Frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt am Main (Germany)

    2010-10-22

    Research highlights: {yields} Strong ADAM15 expression is found in normal melanocytes. {yields} ADAM15 expression is significantly downregulated in patients with melanoma metastasis. {yields} TGF-{beta} can downregulate ADAM15 expression in melanoma cells. {yields} Overexpression of ADAM15 in melanoma cells inhibits migration, proliferation and invasion of melanoma cells. {yields} Conclusion: ADAM15 represents an tumor suppressor protein in melanoma. -- Abstract: In a mouse melanoma metastasis model it has been recently shown that ADAM15 overexpression in melanoma cells significantly reduced the number of metastatic nodules on the lung. Unfortunately, the expression of ADAM15 in human melanoma tissue has not been determined so far. In our study, we characterized the expression of ADAM15 in tissue micro-arrays of patients with primary melanoma with melanoma metastasis. ADAM15 was expressed in melanocytes and endothelial cells of benign nevi and melanoma tissue. Importantly, ADAM15 was significantly downregulated in melanoma metastasis compared to primary melanoma. We further demonstrate that IFN-{gamma} and TGF-{beta} downregulate ADAM15 protein levels in melanoma cells. To investigate the role of ADAM15 in melanoma progression, we overexpressed ADAM15 in melanoma cells. Importantly, overexpression of ADAM15 in melanoma cells reduced the migration, invasion and the anchorage dependent and independent cell growth of melanoma cells. In summary, the downregulation of ADAM15 plays an important role in melanoma progression and ADAM15 act as a tumorsuppressor in melanoma.

  1. Pediatric Melanoma and Drug Development

    Directory of Open Access Journals (Sweden)

    Klaus Rose

    2018-03-01

    Full Text Available Importance—Pediatric melanoma occurs, albeit rarely. Should patients be treated by today’s medical standards, or be subjected to medically unnecessary clinical studies? Observations—We identified international, industry-sponsored pediatric melanoma studies triggered by regulatory demands in www.clinicaltrials.gov and further pediatric melanoma studies demanded by European Union pediatric investigation plans. We retrieved related regulatory documents from the internet. We analyzed these studies for rationale and medical beneficence on the basis of physiology, pediatric clinical pharmacology and rationale. Regulatory authorities define children by chronological age, not physiologically. Newborns’ organs are immature but they develop and mature rapidly. Separate proof of efficacy in underage patients is justified formally/regulatorily but lacks medical sense. Children—especially post-puberty—and adults vis-a-vis medications are physiologically very similar. Two adolescent melanoma studies were terminated in 2016 because of waning recruitment, while five studies in pediatric melanoma and other solid tumors, triggered by European Union pediatric investigation plans, continue recruiting worldwide. Conclusions and Relevance—Regulatory-demanded pediatric melanoma studies are medically superfluous. Melanoma patients of all ages should be treated with effective combination treatment. Babies need special attention. Children need dose-finding and pharmacokinetic studies but adolescents metabolize and respond to drugs similarly to adults. Institutional Review Boards/ethics committees should suspend ongoing questionable pediatric melanoma studies and reject newly submitted questionable studies.

  2. Histopathological findings concerning ocular melanomas.

    Science.gov (United States)

    Costache, Mariana; Pătraşcu, Oana Maria; Dumitru, Adrian; Costache, Diana; Voinea, Liliana Mary; Simionescu, Olga; Sajin, Maria

    2014-01-01

    Ocular melanoma is rare in clinical practice. In this study, we present three cases of ocular melanoma surgically removed in the Department of Ophthalmology of the Emergency University Hospital of Bucharest, Romania, and diagnosed in the Department of Pathology of the same hospital using conventional histopathological techniques and immunohistochemical tests.

  3. Angiogenic profile of uveal melanoma.

    NARCIS (Netherlands)

    Notting, I.C.; Missotten, G.S.; Sijmons, B.; Boonman, Z.F.; Keunen, J.E.E.; Pluijm, G. van der

    2006-01-01

    Uveal melanoma develops in one of the most capillary-rich tissues of the body and is disseminated hematogenously. Knowledge of the nature and the spatiotemporal expression of angiogenic factors in uveal melanoma is essential to the development of new treatment strategies, especially with regard to

  4. Clinical characteristics and management of melanoma families

    NARCIS (Netherlands)

    Rhee, Jasper Immanuel van der

    2013-01-01

    Being a member of a melanoma family is a major risk factor for cutaneous malignant melanoma. In this thesis clinical characteristics and management of melanoma families are discussed. In the first part of the thesis clinical and histological characteristics of melanoma (patients) from families with

  5. Comparative Aspects of Canine Melanoma

    Directory of Open Access Journals (Sweden)

    Adriana Tomoko Nishiya

    2016-02-01

    Full Text Available Melanomas are malignant neoplasms originating from melanocytes. They occur in most animal species, but the dog is considered the best animal model for the disease. Melanomas in dogs are most frequently found in the buccal cavity, but the skin, eyes, and digits are other common locations for these neoplasms. The aim of this review is to report etiological, epidemiological, pathological, and molecular aspects of melanomas in dogs. Furthermore, the particular biological behaviors of these tumors in the different body locations are shown. Insights into the therapeutic approaches are described. Surgery, chemotherapy, radiotherapy, immunotherapy, and the outcomes after these treatments are presented. New therapeutic perspectives are also depicted. All efforts are geared toward better characterization and control of malignant melanomas in dogs, for the benefit of these companion animals, and also in an attempt to benefit the treatment of human melanomas.

  6. Entre a Ação e a Especulação: o Papel do Corpo em Matéria e Memória

    Directory of Open Access Journals (Sweden)

    Diogo da Costa Fernandes

    2017-02-01

    Full Text Available Este artigo pretende apresentar a discussão do filósofo Henri Bergson acerca do papel do corpo no primeiro capítulo da obra Matéria e Memória: ensaio sobre a relação do corpo com o espírito. O estudo da percepção é o mote principal que orientará a proposta desse artigo. Seguiremos uma argumentação que vai desde uma abordagem da contribuição do sistema nervoso na transmissão dos estímulos recebidos dos objetos exteriores ao corpo humano até uma explicação do que seria a percepção em seu estado mais puro. Também apresentaremos uma das principais conclusões de Bergson quanto ao papel do corpo para a vida do ser humano: o corpo tem uma função ativa, não sendo destinado à especulação. Por fim, esse artigo pretende focar em uma reconstrução da argumentação de Bergson, a partir de uma estratégia hermenêutica, visto que detalha os principais argumentos do autor quanto ao papel do corpo em Matéria e Memória.

  7. Ensaio sobre desenvolvimento humano na pós-modernidade

    OpenAIRE

    Abib,José Antônio Damásio

    2008-01-01

    Neste ensaio, o conceito de desenvolvimento humano na pós-modernidade apóia-se em uma filosofia pós-moderna de direitos humanos, e na modernidade apóia-se em uma filosofia moderna de direitos humanos. O Estado moderno fracassou na realização da filosofia moderna dos direitos humanos. Uma filosofia pós-moderna de direitos humanos deixa para trás a filosofia moderna de direitos humanos. Isso significa abandonar o fundacionismo ético e as grandes narrativas emancipatórias de desenvolvimento huma...

  8. Del Recurso Humano al humano con recursos: una propuesta en el estudio de encadenamientos socioproductivos para el Turismo de intereses especiales en el territorio Patagonia Verde Chile

    Directory of Open Access Journals (Sweden)

    Guillermo Sebastián Pacheco Habert

    2012-01-01

    Full Text Available El tema del humano con recurso, enfoque de este trabajo, tiene un papel importantísimo a la hora de transitar de estrategias competitivas hacia estrategias colaborativas, sobre todo cuando se perciben logros ecosocioeconómicos que avanzan hacia la dirección de un desarrollo territorial. Se tiene como hipótesis, que desde el enfoque de los encadenamientos socioproductivos, centrado en el turismo de intereses especiales, es posible comprender y establecer objetivos comunes dentro de actores, organizaciones, emprendimientos y comunidades locales. El objetivo de este artículo es proponer una aproximación teórica sobre el TIE (Turismo de Intereses Especiales sobre las aglomeraciones, sobre los encadenamientos socioproductivos y sobre el enfoque del humano con recurso, para posteriormente relatar los primeros resultados de esta investigación realizada en los cinco municipios que hacen parte del territorio turístico denominado "Patagonia Verde", en el sur de Chile. A partir de la identificación de actores clave, se aplicaron entrevistas a éstos y fichas de caracterización a emprendimientos. Posteriormente se identificaron fortalezas y oportunidades que puedan ser potenciadas a partir de la perspectiva del humano con recurso. A partir de los encadenamientos socioproductivos, contar con individuos conscientes y proactivos dentro de las instituciones y organizaciones en tareas y ejes estratégicos del desarrollo turístico y que compartan con la perspectiva del desarrollo territorial sustentable, es uno de los desafíos que aquí proponemos. Son los sujetos quienes son capaces de generar las condiciones institucionales para otra forma de comprender y actuar en Turismo.

  9. Interactive Tailored Website to Promote Sun Protection and Skin Self-Check Behaviors in Patients With Stage 0-III Melanoma

    Science.gov (United States)

    2017-11-15

    Stage 0 Skin Melanoma; Stage I Skin Melanoma; Stage IA Skin Melanoma; Stage IB Skin Melanoma; Stage II Skin Melanoma; Stage IIA Skin Melanoma; Stage IIB Skin Melanoma; Stage IIC Skin Melanoma; Stage III Skin Melanoma; Stage IIIA Skin Melanoma; Stage IIIB Skin Melanoma; Stage IIIC Skin Melanoma

  10. Histological Types of Polypoid Cutaneous Melanoma II

    OpenAIRE

    Knežević, Fabijan; Duančić, Vjekoslav; Šitić, Sanda; Horvat-Knežević, Anica; Benković, Vesna; Ramić, Snježana; Kostović, Krešimir; Ramljak, Vesna; Velemir Vrdoljak, Danko; Stanec, Mladen; Božović, Angelina

    2007-01-01

    The aim of this study was to ascertain which histological types of melanoma can clinically and morphologically appear as polypoid melanomas. In 645 cases of primary cutaneous melanoma we have analyzed criteria for diagnosis of polypoid cutaneous melanoma and afterwards we have analyzed growth phase in each polypoid melanoma, histological type of atypical melanocytes, the number of epidermal ridges which are occupied by atypical melanocytes, and distribution according to age, sex a...

  11. Brachytherapy of choroidal melanomas

    International Nuclear Information System (INIS)

    Brady, L.W.; Hernandez, J.C.

    1992-01-01

    In a compilation of nine reported series consisting of 2,024 enucleations, the five- and ten-year survivals following surgery were 63% and 43%, respectively. The 25-year survival has been reported to be 40%. In 1974 at Wills Eye Hospital and Hahnemann University, the cobalt-60 plaques technique was introduced. During the following years, other radioactive isotopes were introduced including irridium-192, iodine-125, ruthenium-106/rhodium-106 and more recently palladium-103. At the present time, iodine-125 is the most widely used radionuclide. Until now, 302 patients treated with plaque brachytherapy showed an actuarial survival of 77% and 67.8% at five and eight years, respectively. There was no significant survival difference when compared with a similar group of patients undergoing enucleation. Other retrospective studies show similar excellent results. In spite of these convincing results, the decision making process in management melanoma remains unsettled primarily due to the absence of prospective randomized trials. Because of this, the Collaborative Ocular Melanoma Study was initiated. From the standpoint of toxicity, the data are available on ocular radiation toxicity. In an analysis of 77 patients from the Wills Eye Hospital with pretreatment visual acuities of 20/25 or better, it was noted that 90% of patients who had received less than 500 Gy to the fovea retained visual acuity of 20/200 or better while only 52% of patients receiving more than 5,000 Gy to the fovea had vision of 20/200 or better. A serious late effect of radioactivity plaque treatment is scleral necrosis which may require repair or enucleation even in the absence of tumor progression. Enucleation may be necessary in approximately 10% of patients. We conclude that malignant melanoma of the uvea can be safely treated with radioactive plaques. (orig./MG) [de

  12. Preventing Melanoma PSA (:60)

    Centers for Disease Control (CDC) Podcasts

    2015-06-02

    This 60 second public service announcement is based on the June 2015 CDC Vital Signs report. Skin cancer is the most common form of cancer in the U.S. In 2011, there were more than 65,000 cases of melanoma, the most deadly form of skin cancer. Learn how everyone can help prevent skin cancer.  Created: 6/2/2015 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 6/2/2015.

  13. Dermoscopy of melanoma and non-melanoma skin cancer.

    Science.gov (United States)

    Babino, G; Lallas, A; Longo, C; Moscarella, E; Alfano, R; Argenziano, G

    2015-10-01

    Skin cancer is a major health problem because of its high incidence in white populations, as well as its related potential morbidity and mortality. Dermoscopy is a noninvasive tool that allows the identification of specific morphological features in different skin tumors, improving significantly the early diagnosis of melanoma and non-melanoma skin cancer (NMSC). This tool has also gained increased interest in the management of NMSC therapy and in the post-treatment follow-up. In this article, we provide a review of the dermoscopic patterns and criteria for the diagnosis of melanoma and NMSC described until now in the literature.

  14. LEITURA E SEUS SUPORTES: papel e digital

    Directory of Open Access Journals (Sweden)

    Celso Leopoldo Pagnan

    2016-09-01

    Full Text Available Pesquisas pioneiras (Mangen; Walgermo; Brønnick, 2012 têm destacado o modo de ler textos curtos ou livros inteiros em dois suportes: digital e papel. Há uma suposição de que os jovens tendem a preferir a leitura digital ao suporte papel, porém pode não ser uma verdade absoluta, conforme atestam outras pesquisas (PewResearch Center, 2014. Com base em dados desses estudos, bem como na aplicação de testes em alunos do ensino médio, o presente trabalho parte do pressuposto de que o nível de percepção dos leitores pode ser relativamente diferente conforme o suporte utilizado. Para tanto, utilizamos como metodologia a aplicação de um teste de leitura em vinte e nove alunos, que leram textos curtos, com um ou dois parágrafos, em um suporte digital, tablet, e responderam a questões de compreensão sobre tais textos; repetindo o procedimento com outros textos em suporte papel. A hipótese era de que os alunos apresentassem modos diferentes de compreensão textual de acordo com o suporte utilizado. A análise dos dados coletados revelou um resultado sutilmente superior na compreensão dos textos impressos, porém insuficiente para ser generalizado como resultado conclusivo, não deixando, entretanto, de apontar caminhos significativos para a compreensão das práticas leitoras na escola.

  15. Régimen Dictadura Autoritaria Década de Brasil de 1960 y Violaciónes Derechos Humanos Reconocidos en Gomes Lund Caso y Otras que Falta en la Guerrilla Araguaia

    OpenAIRE

    Eudes Vitor Bezerra; Marcelo Negri Soares

    2016-01-01

    La premisa de que la Corte Interamericana de Derechos Humanos ha desempeñado un papel importante en la escena latinoamericana. En caso de condena "Gome Lund y otros" que resonaron en la reparabilidad de las personas desaparecidas. Vamos a utilizar el método hipotético-deductivo , con inversiones en la investigación dogmática y jurisprudencial, con la hipótesis inicial a través de un estudio evaluó la efectividad de los Derechos Humanos y la (in)aplicabilidad de la Ley 9.140/95 .

  16. Régimen Dictadura Autoritaria Década de Brasil de 1960 y Violaciónes Derechos Humanos Reconocidos en Gomes Lund Caso y Otras que Falta en la Guerrilla Araguaia

    Directory of Open Access Journals (Sweden)

    Eudes Vitor Bezerra

    2016-06-01

    Full Text Available La premisa de que la Corte Interamericana de Derechos Humanos ha desempeñado un papel importante en la escena latinoamericana. En caso de condena "Gome Lund y otros" que resonaron en la reparabilidad de las personas desaparecidas. Vamos a utilizar el método hipotético-deductivo , con inversiones en la investigación dogmática y jurisprudencial, con la hipótesis inicial a través de un estudio evaluó la efectividad de los Derechos Humanos y la (inaplicabilidad de la Ley 9.140/95 .

  17. Por que administrar estrategicamente recursos humanos?

    OpenAIRE

    Almeida,Martinho Isnard Ribeiro de; Teixeira,Maria Luiza Mendes; Martinelli,Dante Pinheiro

    1993-01-01

    Este artigo aborda a necessidade de se dar um tratamento estratatégico à Administração de Recursos Humanos, da mesma forma como normalmente ocorre em outras áreas da Administração, de maneira que as Organizações possam estabelecer um relacionamento positivo e duradouro com o seu ambiente. O artigo sugere, de forma prática, algumas atividades de Recursos Humanos que deverão estar presentes nas diferentes etapas de um plano estratégico. This text deals with the necessity of a strategic treat...

  18. Los derechos humanos en el deporte

    OpenAIRE

    Kidd, Bruce

    2004-01-01

    Los derechos humanos en el deporte se refieren a un mandato genérico que abarca una serie de derechos relacionados entre sí. La base del movimiento a favor de los derechos radica en aceptar el concepto fundamental de que el deporte y el tiempo libre son un derecho de todos los seres humanos, necesario para su desarrollo, su salud y para el bienestar tanto de los individuos como de la sociedad. Los deportistas han luchado por el derecho a ser tratados con justicia y dignidad en todos los aspec...

  19. Globalización y desarrollo humano

    OpenAIRE

    Unceta Satrustegui, Koldo

    1999-01-01

    Este trabajo analiza las relaciones existentes entre la creciente globalización de las actividades económicas y las posibilidades de desarrollo humano. Para ello, se realizan en primer término algunas precisiones conceptuales sobre el fenómeno de la globalización, distinguiendo entre los aspectos cuantitativos y cualitativos de la misma. A continuación se plantean las premisas de la ampliación de las capacidades y las libertades como características básicas del desarrollo humano, y las limita...

  20. Os direitos humanos e seus paradoxos

    OpenAIRE

    Proner, Caroline

    2001-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Jurídicas. Programa de Pós-Graduação em Direito Como resultado final dessa investigação, que pretendeu confrontar, mediante análise procedimental, os limites e avanços do sistema americano de proteção de direitos humanos com a realidade do paradoxo fundamental, algumas considerações podem ser apresentadas : o sistema americano de proteção de direitos humanos ; o suposto consenso da universalização dos direi...

  1. Constituição brasileira, direitos humanos e educação

    OpenAIRE

    Roseli Fischmann

    2009-01-01

    El tema de la 31ª Reunión Anual de la ANPEd celebra los 20 años de la Constitución brasileña, los 60 años de la Declaración Universal de los Derechos Humanos y los entrelazamientos de ambos con la educación. Esos documentos jurídicos magnos, uno internacional y otro nacional, tienen en común el hecho de haber sido elaborados en momentos de postruptura, y el de atribuir destacado papel a la educación en la reconstrucción democrática. Hay que considerar también dos procesos en el campo jurídico...

  2. PAPEL DO BRIC NA ECONOMIA MUNDIAL

    Directory of Open Access Journals (Sweden)

    Leandro Bruno Santos

    2010-01-01

    Full Text Available Se evalúa el papel de los países BRIC - Brasil, China, India, Rusia y Sudáfrica - en la economía mundial en los primeros años de este siglo. Actualmente, con la crisis fi nanciera internacional y la desaceleración económica en los países desarrollados, algunos analistas han argumentado que el BRIC tendrá un papel importante en el crecimiento económico sostenido de la economía mundial. Se examina cuidadosamente esta hipótesis de independencia del BRIC en relación con las economías desarrolladas, a partir de datos estadísticos, tales como PIB, ingreso per cápita, el comercio, la inversión- extranjera directa, la internacionalización de las empresas, entre otros, obtenidos de las principales organizaciones internacionales como Conferencia de las Naciones Unidas para el Comercio y desarrollo (UNCTAD y Banco Mundial.

  3. Melanoma Surveillance in the US: The Economic Burden of Melanoma

    Centers for Disease Control (CDC) Podcasts

    2011-10-19

    This podcast accompanies the publication of a series of articles on melanoma surveillance in the United States, available in the November supplement edition of the Journal of the American Academy of Dermatology. Dr. Gery Guy, from the CDC’s Division of Cancer Prevention and Control, discusses the economic burden of melanoma.  Created: 10/19/2011 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 10/19/2011.

  4. Superficial melanomas of oral mucous membranes.

    Science.gov (United States)

    Regezi, J A; Hayward, J R; Pickens, T N

    1978-05-01

    In accordance with microscopic and clinical criteria established for superficial melanomas of the skin (superficial spreading melanoma, lentigo maligna melanoma, acral-lentiginous melanoma), three oral lesions have been evaluated. The literature on oral melanomas has also been reviewed, with special attention given to those cases that had pre-existing melanosis. One patient with a diagnosis of superficial spreading melanoma eventually died of his untreated lesion 11 years after its first appearance. Two patients had lesions diagnosed as acral-lentiginous melanoma (a group which also includes volar and subungual melanomas) that exhibited aggressive, recurrent behavior. These lesions had microsocpic features similar to lentigo maligna melanoma but did not behave in a manner consistent with that diagnosis. Electron microscopic study of one acral-lentiginous melanoma demonstrated malenosomes and premelanosomes that were like those seen in normal melanocytes and nevus cells. The superficial or radial growth phase of many oral melanomas has apparently gone unrecognized. Melanosis has been reported to be a common feature of invasive oral melanomas but has not generally been related to the natural history of these lesions. Oral lesions with a prolonged intra-epithelial or radial growth phase would be expected to have a better prognosis than nodular melanomas, but meaningful survival data are not available because of the infrequency with which oral melanomas have been subclassified.

  5. Primary dermal melanoma: a West Australian cohort.

    Science.gov (United States)

    Teow, James; Chin, Olivia; Hanikeri, Mark; Wood, Benjamin A

    2015-09-01

    The objectives of this study were to identify a subgroup of patients with putative primary dermal melanoma after thorough multidisciplinary clinical and histological evaluation, and to describe the clinical, histological and selected molecular features of these lesions. The records of the Western Australian Melanoma Advisory Service were searched for potential cases of primary dermal melanoma. The clinical and histological features were reviewed, immunohistochemical assessment was performed and clinical outcomes recorded. Eighteen cases of putative primary dermal melanoma with available clinical data were identified. Two of 12 cases in which further histological sections could be obtained were excluded because of the presence of findings suggesting an epidermal origin on these further sections. In one additional case, such origin could not be histologically excluded. Median follow-up period for the remaining cases was 68 months. Confirmed primary dermal melanoma accounts for 0.87% of cases of melanoma referred to a subspecialist melanoma advisory service. These cases show significant histological overlap with dermal/subcutaneous metastases of melanoma, but display a relatively good prognosis, with a 5-year survival of 87.5%. Our results support the recognition of a distinct group of melanoma that mimics metastatic melanoma, but is associated with a relatively favourable outcome. The group of putative primary dermal melanoma is likely to be heterogenous, including cases of primary nodular melanoma in which epidermal connection has not been identified, metastatic melanoma with an occult primary lesion and true primary dermal melanoma. © 2015 Royal Australasian College of Surgeons.

  6. Melanoma of the skin in the Danish Cancer Registry and the Danish Melanoma Database

    DEFF Research Database (Denmark)

    Pedersen, Sidsel Arnspang; Schmidt, Sigrun Alba Johannesdottir; Klausen, Siri

    2018-01-01

    BACKGROUND: The nationwide Danish Cancer Registry and the Danish Melanoma Database both record data on melanoma for purposes of monitoring, quality assurance and research. However, the data quality of the Cancer Registry and the Melanoma Database has not been formally evaluated. METHODS: We...... estimated the positive predictive value (PPV) of melanoma diagnosis for random samples of 200 patients from the Cancer Registry (n=200) and the Melanoma Database (n=200) during 2004-2014, using the Danish Pathology Registry as 'gold-standard' reference. We further validated tumor characteristics...... in the Cancer Registry and the Melanoma Database. Additionally, we estimated the PPV of in situ melanoma diagnoses in the Melanoma Database, and the sensitivity of melanoma diagnoses in 2004-2014. RESULTS: The PPVs of melanoma in the Cancer Registry and the Melanoma Database were 97% (95% CI, 94-99) and 100...

  7. High accuracy of family history of melanoma in Danish melanoma cases

    DEFF Research Database (Denmark)

    Wadt, Karin A W; Drzewiecki, Krzysztof T; Gerdes, Anne-Marie

    2015-01-01

    The incidence of melanoma in Denmark has immensely increased over the last 10 years making Denmark a high risk country for melanoma. In the last two decades multiple public campaigns have sought to increase the awareness of melanoma. Family history of melanoma is a known major risk factor...... but previous studies have shown that self-reported family history of melanoma is highly inaccurate. These studies are 15 years old and we wanted to examine if a higher awareness of melanoma has increased the accuracy of self-reported family history of melanoma. We examined the family history of 181 melanoma...... probands who reported 199 cases of melanoma in relatives, of which 135 cases where in first degree relatives. We confirmed the diagnosis of melanoma in 77% of all relatives, and in 83% of first degree relatives. In 181 probands we validated the negative family history of melanoma in 748 first degree...

  8. Dilemas Éticos Enfrentados por Profissionais de Recursos Humanos: Explorando Cursos de Ação Beatriz Maria Braga

    Directory of Open Access Journals (Sweden)

    Beatriz Maria Braga

    2017-11-01

    Full Text Available Embora o tema do papel que a área e os profissionais de Recursos Humanos (RH têm a desempenhar em questões éticas venha ganhando destaque na literatura internacional, ainda são escassos os trabalhos sobre esse tema no Brasil (Santos, Mendonça, & Demo, 2015. A partir de uma pesquisa qualitativa conduzida com 23 gestores de RH de empresas nacionais e internacionais, este trabalho investigou as percepções de profissionais de RH sobre o seu papel em relação às questões éticas da gestão de pessoas, os dilemas que enfrentam e a sua conduta frente a esses dilemas. Como resultados, observou-se que os entrevistados entendem que o seu principal papel é atuar como parceiros do negócio, e que as pessoas têm valor porque contribuem para o desempenho organizacional. Ademais, acreditam que desempenham um papel importante na conciliação dos objetivos, muitas vezes, conflitantes das organizações e dos funcionários. Relataram que se sentem pressionados pelos dilemas éticos que dizem respeito às informações a que tem acesso, ao desempenho das funções da área de RH e ao seu papel de especialistas. Observou-se também que se sentem guardiões da ética nas organizações, devendo dar o exemplo às demais áreas. Os resultados mostram as especificidades da tomada de decisão do profissional de RH, em que diferentes fatores influenciam os cursos de ação.

  9. Interacciones humano-animal: características e implicaciones para el bienestar de los humanos

    Directory of Open Access Journals (Sweden)

    Natalia Piar

    2007-07-01

    Full Text Available En este artículo se revisa la literatura reciente sobre interacciones humano-animal, su origen, sus características y cómo dichas interacciones afectan el bienestar físico, psicológico y social. En la primera parte se presentan los orígenes y evolución histórica de las relaciones humano - animal, empezando por los procesos de domesticación y se aborda la naturaleza de las interacciones humano animal. En la segunda parte, se revisan los efectos para los humanos de la interacción con animales, especialmente con sus mascotas y se analiza la literatura científica sobre los efectos físicos, psicológicos y sociales. Finalmente, se aborda brevemente el desarrollo de esta área de investigación en Latinoamérica.

  10. EPIDEMIOLOGIA DEL VIRUS PAPILOMA HUMANO (HPV)

    OpenAIRE

    Rivera Z.,René; Aguilera T.,Jorge; Larraín H,Angélica

    2002-01-01

    Se presenta una revisión de la epidemiología del Virus Papiloma Humano (HPV). Patogenia, prevalencia mundial, magnitud de la infección, factores de riesgo, algunas lesiones producidas según tipo específico y se describe el concepto de clearance y persistencia viral.

  11. Los incómodos derechos humanos

    OpenAIRE

    Kesch, Emilie

    2014-01-01

    A casi sesenta y un años de la firma del tratado por la ONU sobre los Derechos Humanos son innumerables los asesinatos, genocidios, y torturas ocurridos en todo el mundo. Basta con ojear un :poco en nuestro pasado histórico para darnos cuenta que la teoría difiere abismalmente de la práctica.

  12. O PAPEL DA ALIENAÇÃO DO TRABALHO MARXIANA NA CONSTRUÇÃO DO CARÁTER SOCIAL

    Directory of Open Access Journals (Sweden)

    Tainã Alcantara de Carvalho

    2014-02-01

    Full Text Available O presente artigo pretende realizar uma discussão acerca do modo de exploração do trabalho humano pelo capital enquanto fonte formadora do caráter individual e, com isto, social. Baseado no pensamento filosófico e econômico marxista, que inicia a crítica ao modo de produção capitalista calcada principalmente nas questões humanas, será demonstrado um rápido panorama da evolução dos modelos de produção a partir da Revolução Industrial até o moderno modelo de acumulação flexível, salientando nesta análise considerações a respeito da relação do ser humano com o trabalho, que permeia tanto as análises sociológicas quanto psicológicas. Partindo da ideia construída por Marx acerca da centralidade da atividade laboral ao ser humano, presente em sua teoria do materialismo histórico, o autor relata em suas obras as consequências que a alienação do trabalho, ao modo de sua época, geram à formação do indivíduo e à percepção deste sobre o mundo ao seu redor. Com base nesta ideia, pretende-se demonstrar neste artigo a continuação do papel da alienação do trabalho à constituição do ser humano no século XX, principalmente no que tange às considerações acerca dos novos valores e comportamentos adotados na modernidade.

  13. O PAPEL DA GESTÃO DE PESSOAS NA ESTRATÉGIA: UM ESTUDO DE CASO EM UMA EMPRESA DO SETOR AUTOMOTIVO DO PARANÁ

    Directory of Open Access Journals (Sweden)

    Camila Bruning

    2015-05-01

    Full Text Available Neste artigo discute-se o papel da gestão de pessoas para o alcance dos objetivos estratégicos da organização por meio de estudo de caso em uma empresa do setor automotivo localizada no Paraná. A hipótese que se verifica é a de que a gestão de pessoas tem papel estratégico ao ir além de suas tradicionais atividades administrativas de recursos humanos e passar a atuar integrada com a gestão estratégica do negócio, trabalhando para promover a aprendizagem organizacional, a gestão da cultura organizacional e o comprometimento, através de práticas que que tem como consequencia o sequestro da subjetividade do trabalhador (Faria e Meneghetti 2001.

  14. o papel da L-arginina na doença renal : Monografia : <> role of L-arginine in the renal disease

    OpenAIRE

    Duarte, Diana Maria Cristóvão

    2009-01-01

    Resumo da tese: Ao longo dos útimos anos assistiu-se a um crescente entusiasmo sobre o papel da L-arginina no atraso da progressão da doença renal. Apesar dos estudos em humanos já terem mostrado alguns resultados, o quadro geral do papel da L-arginina na doença renal está ainda por definir. A L-arginina é um aminoácido semi-essencial e um substrato para a síntese de NO, poliaminas, agmatina e outros. Alguns destes metabolitos são capazes de atrasar a progressão da doença e, desta forma, a in...

  15. Podoplanin Expression in Canine Melanoma.

    Science.gov (United States)

    Ogasawara, Satoshi; Honma, Ryusuke; Kaneko, Mika K; Fujii, Yuki; Kagawa, Yumiko; Konnai, Satoru; Kato, Yukinari

    2016-12-01

    A type I transmembrane protein, podoplanin (PDPN), is expressed in several normal cells such as lymphatic endothelial cells or pulmonary type I alveolar cells. We recently demonstrated that anticanine PDPN monoclonal antibody (mAb), PMab-38, recognizes canine PDPN of squamous cell carcinomas, but does not react with lymphatic endothelial cells. Herein, we investigated whether PMab-38 reacts with canine melanoma. PMab-38 reacted with 90% of melanoma cells (9/10 cases) using immunohistochemistry. Of interest, PMab-38 stained the lymphatic endothelial cells and cancer-associated fibroblasts in melanoma tissues, although it did not stain any lymphatic endothelial cells in normal tissues. PMab-38 could be useful for uncovering the function of PDPN in canine melanomas.

  16. Podoplanin Expression in Canine Melanoma

    OpenAIRE

    Ogasawara, Satoshi; Honma, Ryusuke; Kaneko, Mika K.; Fujii, Yuki; Kagawa, Yumiko; Konnai, Satoru; Kato, Yukinari

    2016-01-01

    A type I transmembrane protein, podoplanin (PDPN), is expressed in several normal cells such as lymphatic endothelial cells or pulmonary type I alveolar cells. We recently demonstrated that anticanine PDPN monoclonal antibody (mAb), PMab-38, recognizes canine PDPN of squamous cell carcinomas, but does not react with lymphatic endothelial cells. Herein, we investigated whether PMab-38 reacts with canine melanoma. PMab-38 reacted with 90% of melanoma cells (9/10 cases) using immunohistochemistr...

  17. Case studies of skin melanoma

    Directory of Open Access Journals (Sweden)

    A. V. Kozlova

    2015-01-01

    Full Text Available Skin melanoma is a malignant tumor originating in the cells of the melanocytic system, which is characterized by an aggressive clinical course, significant metastatic potential and unfavorable prognosis. These features of the tumor stipulate the need to improve measures to optimize early diagnosis of tumors. The article presents cases of pigmented skin melanoma to demonstrate the variability of clinical manifestations of this tumor requiring dermatologist skills in the differential diagnostics of neoplasms.

  18. [Choroidal melanoma - evolution and prognosis].

    Science.gov (United States)

    Chiruţa, Daria; Stan, Cristina

    2014-01-01

    Choroidal melanoma is the most common primary intraocular malignant tumor. We present the case of a 62 year old patient who was diagnosed with intraocular tumor in his right eye, for about three years. Regarding the fact that the patient refused any kind of treatment during this period, we just had the opportunity to monitor this case. Finally, the diagnosis was choroidal melanoma, confirmed by the histopathological exam.

  19. Umbilicus reconstruction after melanoma excision

    Directory of Open Access Journals (Sweden)

    Miguel Costa-Silva

    2017-01-01

    Full Text Available An 81-year-old woman was admitted with a nodular cutaneous melanoma of the abdominal wall involving the umbilicus. After performing wide excision with 2 cm margin of the melanoma, umbilical reconstruction and defect closure were planned. After careful consideration, we decided to use an island pedicle flap which allowed closure of the defect and reconstruction of the umbilicus.

  20. Melanoma maligno em búfalos (Bubalus bubalis albinos

    Directory of Open Access Journals (Sweden)

    Maria Cecília Florisbal Damé

    2015-10-01

    Full Text Available Descrevem-se melanomas múltiplos em dois búfalos albinos da raça Murrah no Sul do Brasil. Macroscopicamente havia múltiplos tumores enegrecidos no músculo esquelético, pulmões, linfonodos, saco pericárdio, cápsula renal, mediastino e pleura. Microscopicamente foram observadas células epitelióides poliédricas dispostas em ninhos sólidos ou fascículos entrelaçados sustentadas por um estroma colagenoso fino e esparso. O citoplasma era eosinofílico e por vezes continham quantidades variáveis de pigmento de melanina. A taxa de mitose foi baixa. Na imuno-histoquímica houve imunomarcação positiva utilizando anticorpo anti-tirosinase, anti-Melan-A, anti-vimentina, anti-proteína S-100 e antineurofilamento. É possível que o polimorfismo relacionado com o gene da pigmentação em búfalos albinos tenha contribuído para o maior risco de desenvolvimento de melanomas, como foi sugerido em humanos.

  1. El papel del lenguaje y la escritura para las víctimas. El enfrentamiento con el pasado conflictivo en Guatemala

    Directory of Open Access Journals (Sweden)

    Nadine Haas

    2014-06-01

    Full Text Available La historia de Guatemala se caracteriza por una larga tradición de violencia política y regímenes autoritarios. Los textos literarios que se analizan a continuación –Insensatez de Horacio Castellanos Moya (*1957 y El material humano de Rodrigo Rey Rosa (*1958– giran precisamente alrededor de las políticas frente al pasado y nos permiten pensar de manera más detallada en el papel de la escritura y del lenguaje en el proceso de “hacer memoria”.

  2. La violencia intrafamiliar y el papel del estado como impulsor de políticas públicas de prevención y de lucha

    OpenAIRE

    Rodembusch, Claudine Freire

    2011-01-01

    Este trabajo de investigación se ocupa del análisis de la violencia intrafamiliar y el papel del Estado como impulsor de políticas públicas de prevención y lucha de este tipo de violencia. Se presenta, en un primer momento, un abordaje histórico y conceptual sobre los derechos humanos. En un segundo momento, se analiza el ambiente familiar, examinando la evolución de la familia; las familias en situaciones especiales; la infancia; la violencia contra el niño, así como el tipo de violencia de ...

  3. Sociedad civil y derecho internacional de los derechos humanos en Argentina

    Directory of Open Access Journals (Sweden)

    Yanina Guthmann

    2015-07-01

    Full Text Available La aplicación del derecho internacional de los derechos humanos (DIDH en el ámbito local argentino y su impacto en este país, no pueden desligarse de la historia reciente: las graves violaciones de los derechos humanos cometidas durante la dictadura (1976–1983. En este sentido, la sentencia de 2005 que anula las leyes llamadas de impunidad y que se basó en el DIDH representa una reorganización de la relación entre política y derecho y marca el rol esencial de la sociedad civil en el juego de diálogos y tensiones entre los poderes ejecutivo y judicial, y entre soberanía y DIDH. En el marco del reclamo permanente de justicia por parte de amplios sectores de la sociedad argentina, el papel de la "sociedad civil" es insustituible para comprender la transformación del valor normativo del derecho internacional y de los valores que son inherentes a su aplicación.

  4. A fundamentação dos direitos humanos entre natureza e contrato

    Directory of Open Access Journals (Sweden)

    André Luiz Olivier da Silva

    2013-12-01

    Full Text Available http://dx.doi.org/10.5007/1677-2954.2013v12n2p238 O presente artigo aborda o papel do indivíduo nos programas de fundamentação dos direitos humanos, bem como a encruzilhada metodológica à qual eles estão fadados ao esbarrarem na contraposição entre natureza e contrato. Se, por um lado, alguns destes programas defendem a tese dos direitos naturais e afirmam a existência de direitos que os seres humanos possuiriam em razão de sua própria natureza e independente de qualquer convenção ou artifício; por outro, esta tese é rechaçada e substituída pelo argumento do contrato, a partir do qual os indivíduos negociam a adesão a cláusulas convencionadas por suas próprias vontades. Ambos os tipos de programas podem cair nas armadilhas metafísicas do fundacionalismo ao pressupor o mesmo marco metodológico, a saber, o indivíduo, seja a partir de um estado fictício de natureza, seja a partir de um momento prévio de negociação das cláusulas do contrato. Toda fundamentação de direitos humanos está equivocada na medida em que intenta dar razões e fundamentar direitos por meio do indivíduo-sujeito de direito, que é pressuposto como ser racional, livre e igual a todos os outros homens – e esse é o pressuposto tanto das doutrinas dos direitos naturais quanto do contratualismo moral.

  5. Hacia la realización del derecho humano al agua y al saneamiento: El papel de la relatora especial

    Directory of Open Access Journals (Sweden)

    Laura Movilla Pateiro

    2012-01-01

    Full Text Available In the past few years, there have been views developing on the problem of lack of access to portable water and sanitation from which millions of people have suffered in the world from a human rights perspective, culminating in the recognition of the right to water and sanitation by the General Assembly and the Human rights Council in 2010 within the international arena. In this paper we shall examine the role of the work of the Independent Expert on the issue of human rights obligations related to access to safe drinking water and sanitation, commissioned in 2008, and whose mandate has been renewed in 2011 as Special Rapporteur on the human right to safe drinking water and sanitation has had in the development of this right.

  6. A luta pelos direitos humanos: profissionalização de causas e politização do direito

    Directory of Open Access Journals (Sweden)

    Fernanda Rios Petrarca

    Full Text Available Este artigo investiga a relação entre o exercício profissional do direito e os investimentos militantes na defesa dos direitos humanos. Trata-se de examinar, por um lado, as lógicas coletivas e situacionais que configuram a oferta militante no espaço profissional do direito e, por outro, as carreiras individuais, focando tanto na dimensão objetiva, ou seja, no conjunto de recursos sociais, políticos e profissionais de que dispõem os advogados, quanto na sua lógica subjetiva, envolvendo a redefinição ideológica com a profissão. A metodologia adotada consistiu em aplicação de questionários e realização de entrevistas biográficas com os advogados que atuam na área dos direitos humanos em Aracaju. Este trabalho permite demonstrar que experiência do engajamento em direitos humanos exerce um papel determinante para identificação profissional.

  7. Ubiquitination in melanoma pathogenesis and treatment.

    Science.gov (United States)

    Ma, Jinyuan; Guo, Weinan; Li, Chunying

    2017-06-01

    Melanoma is one of the most aggressive skin cancers with fiercely increasing incidence and mortality. Since the progressive understanding of the mutational landscape and immunologic pathogenic factors in melanoma, the targeted therapy and immunotherapy have been recently established and gained unprecedented improvements for melanoma treatment. However, the prognosis of melanoma patients remains unoptimistic mainly due to the resistance and nonresponse to current available drugs. Ubiquitination is a posttranslational modification which plays crucial roles in diverse cellular biological activities and participates in the pathogenesis of various cancers, including melanoma. Through the regulation of multiple tumor promoters and suppressors, ubiquitination is emerging as the key contributor and therefore a potential therapeutic target for melanoma. Herein, we summarize the current understanding of ubiquitination in melanoma, from mechanistic insights to clinical progress, and discuss the prospect of ubiquitination modification in melanoma treatment. © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

  8. The role of nitric oxide in melanoma.

    Science.gov (United States)

    Yarlagadda, Keerthi; Hassani, John; Foote, Isaac P; Markowitz, Joseph

    2017-12-01

    Nitric oxide (NO) is a small gaseous signaling molecule that mediates its effects in melanoma through free radical formation and enzymatic processes. Investigations have demonstrated multiple roles for NO in melanoma pathology via immune surveillance, apoptosis, angiogenesis, melanogenesis, and on the melanoma cell itself. In general, elevated levels of NO prognosticate a poor outcome for melanoma patients. However, there are processes where the relative concentration of NO in different environments may also serve to limit melanoma proliferation. This review serves to outline the roles of NO in melanoma development and proliferation. As demonstrated by multiple in vivo murine models and observations from human tissue, NO may promote melanoma formation and proliferation through its interaction via inhibitory immune cells, inhibition of apoptosis, stimulation of pro-tumorigenic cytokines, activation of tumor associated macrophages, alteration of angiogenic processes, and stimulation of melanoma formation itself. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Tool to Distinguish Moles from Melanoma

    Science.gov (United States)

    “Moles to Melanoma: Recognizing the ABCDE Features” presents photos that show changes in individual pigmented lesions over time, and describes the different appearances of moles, dysplastic nevi, and melanomas.

  10. Large melanoma metastases to the gastrointestinal tract.

    OpenAIRE

    Silverman, J M; Hamlin, J A

    1989-01-01

    It is well known that malignant melanoma can metastasize widely. Although these metastases in the gastrointestinal tract usually appear as small 'bull's-eye' or 'target' lesions, there are a few reports of relatively large melanoma metastases. We report five cases of large melanoma lesions metastatic to the alimentary canal. We also emphasise the consideration of a thorough gastrointestinal tract evaluation in patients with malignant melanoma especially if they are symptomatic.

  11. Unusual presentations of melanoma: melanoma of unknown primary site, melanoma arising in childhood, and melanoma arising in the eye and on mucosal surfaces.

    Science.gov (United States)

    Sondak, Vernon K; Messina, Jane L

    2014-10-01

    Most melanomas present as primary tumors on the skin surface in adults; however, melanomas also arise in the eye and on the mucosal surfaces or present as apparently metastatic disease without any known history of a cutaneous primary. Melanoma is also being diagnosed during childhood more frequently than ever. Surgeons need to be aware of and understand these unusual presentations of melanoma to optimally manage their patients. Copyright © 2014 Elsevier Inc. All rights reserved.

  12. Desarrollo Humano Sustentable: Concepto y Naturaleza

    OpenAIRE

    Fajardo Arturo, Luis Andrés

    2006-01-01

    El concepto de Desarrollo Humano Sustentable; implica una conjunción de elementos económicos; jurídicos; filosóficos y antropológicos que hacen difícil un concepto sintético. Ese problema se hace aún más complejo a la hora de determinar si se trata de un concepto de naturaleza jurídica que pueda ser catalogado como un Derecho Humano; o si más bien se trata de una pretensión política. Sin embargo; el desarrollo doctrinal sobre el tema deja augurar la existencia de un derecho; al menos de exist...

  13. Pregnancy and early-stage melanoma

    NARCIS (Netherlands)

    Daryanani, D; Plukker, JT; De Hullu, JA; Kuiper, H; Nap, RE; Hoekstra, HJ

    2003-01-01

    BACKGROUND. Cutaneous melanomas are aggressive tumors with an unpredictable biologic behavior. It has been suggested that women who present with melanoma during pregnancy have a worse prognosis due to more aggressive behavior of the melanoma. The objective of the current study was to evaluate the

  14. Clinicopathological and molecular aspects of cutaneous Melanoma

    NARCIS (Netherlands)

    Bogenrieder, T.

    2009-01-01

    Clinicopathological and molecular aspects of cutaneous melanoma. Melanoma arises form the transformation of neural crest-derived melanocytes, the pigment cells of the skin, which reside in the basal layer of the epidermis. Melanoma is the deadliest form of skin cancer and one of the most aggressive

  15. Genetic prognostic factors in uveal melanoma

    NARCIS (Netherlands)

    Maat, Willem

    2012-01-01

    Uveal melanoma (UM) is the most common malignancy of the eye in adults and it is the second most common form of melanoma after cutaneous melanoma (CM). The identification of patients who have a high risk of developing metastases would allow the possibility of providing adjuvant therapies to prevent

  16. Melanoma continues to rise throughout the world

    African Journals Online (AJOL)

    Review Article: Melanoma continues to rise throughout the world. 530 ... of melanoma. The radiation in the ultraviolet B range is said to be the critical component. Generally, worldwide, the incidence of melanoma in white people4,5 correlates inversely with .... lymphocytes, mitotic rate, regression, angiolymphatic invasion ...

  17. Decreased tumor-infiltrating lymphocytes in nodular melanomas compared with matched superficial spreading melanomas.

    Science.gov (United States)

    Lin, Richard L; Wang, Thomas J; Joyce, Cara J; Mihm, Martin C; Murphy, George F; Lian, Christine G; Lin, Jennifer Y

    2016-10-01

    Melanoma causes over 9000 deaths annually in the USA. Among its subtypes, nodular melanoma leads to a disproportionate number of fatalities compared with superficial spreading melanoma, the most common subtype. Recent breakthroughs in melanoma research have indicated a strong connection between melanoma virulence and the immune system. We hypothesize that the aggression of nodular melanoma may, in part, be because of decreased recognition by the immune system, as represented by a decreased presence of tumor-infiltrating lymphocytes (TILs), compared with its superficial spreading counterpart. Indeed, TILs on a primary melanoma have been used as a marker for immune response and have prognostic value for survival and sentinel lymph node status. After matching melanoma cases by age, sex, and Breslow thickness, we found significantly fewer TILs in nodular melanomas than in superficial spreading melanomas. This association was prominent in thin (≤2 mm) melanomas and was no longer significant in thick (>2 mm) melanomas. In addition, this difference in TILs was only present in men and not in women. Our finding suggests that nodular melanomas are more frequently associated with absent TILs, providing an avenue for further investigation into differences in immunogenicity of the primary melanoma and whether they underlie the unique virulence of nodular melanoma.

  18. EMPREENDEDORISMO E VALORES HUMANOS: UM ESTUDO CONCEITUAL

    Directory of Open Access Journals (Sweden)

    Luciano Vignochi

    2013-09-01

    Full Text Available O objetivo principal deste artigo foi identificar conceitos de valores humanos em publicações científicas sobre empreendedorismo. Não há um único conceito de valores humanos, gerando diversas abordagens e aplicações do termo em estudos sobre empreendedorismo. Para identificar diferenças conceituais e aplicações práticas, optou-se por realizar uma análise de conteúdo em um portfólio de artigos selecionados em bases de dados. O principal critério de seleção das publicações foi aderência ao tema. Os resultados mostram que valores podem ser definidos como: critérios de julgamento da realidade; aspectos abstratos, cognitivos e afetivos ou características determinantes da personalidade e do comportamento de empreendedores. Valores influenciam a sobrevivência do indivíduo, o crescimento do empreendimento e podem nivelar a congruência do empreendedor e seu propósito de empreendimento com os critérios de convivência social. Ainda foram discriminados resultados de estudos aplicados com vistas a destacar evidências de contribuições práticas de pesquisas sobre valores humanos em empreendedorismo. Futuras investigações para aprofundar e replicar as análises realizadas neste estudo podem contribuir com a formação de empreendedores, a realização de diagnóstico empresarial e com avanços para a consolidação um modelo de desenvolvimento de empresas baseado em valores humanos.

  19. El comportamiento humano y la accientalidad

    OpenAIRE

    Salas Ollé, Carles

    2016-01-01

    El comportamiento humano es un factor que afecta y es afec - tado por las actitudes de las personas, e influye de manera fun - damental en la aparición de los accidentes. por ello, el estudio de dicho comportamiento se convierte en objetivo prioritario para investigar la causalidad de los accidentes y, en consecuen - cia, para los profesionales que se dedican a la prevención de los mismos

  20. Justicia, propiedad intelectual y genoma humano

    Directory of Open Access Journals (Sweden)

    Maria Graciela De Ortuzar

    2014-06-01

    Full Text Available A partir del conocimiento de la secuenciación del genoma humano es posible el descubrimiento de nuevas terapias, drogas, y causas de enfermedades. Sin embargo, lejos de aumentar el acceso a la atención de la salud, el proyecto genoma humano restringió dicho acceso debido a la rápida comercialización y al creciente ?patentamiento del material humano? -hecho que atenta contra el fundamento ético del sistema jurídico internacional de patentes-.En manos exclusivas de monopolios privados, las ?patentes genéticas? pueden traducirse en altísimos costos de nuevas drogas, tests, y tratamientos para los países en desarrollo. Por lo tanto, si bien la salud humana es presentada como el objetivo último de las investigaciones genómicas, la citada comercialización atenta contra el derecho a la salud y el derecho al conocimiento debido a que imponen una mayor desigualdad y vulnerabilidad de los países en desarrollo por su restricción de acceso. Cabe destacar que es en dichos(países donde se obtiene la información primariaii. En éste nuevo orden internacional de distribución en salud impuesto desde la Organización Mundial de Comercio- OMC- y no desde la Organización Mundial de Salud - OMS-; el actor principal en la ley de patentes, y el beneficiario de la protección que la misma provee, no es ahora el que inventa sino el que invierte.iii Por ello, el objetivo general de la presente investigación es elaborar un marco ético-legal universalista, con especificación plural en ámbitos locales, que regule la investigación del genoma humano en pos de la justa distribución de sus beneficios .

  1. Homo floresiensis. Humanos distintos a nosotros.

    OpenAIRE

    Carlos Alberto Marmelada

    2008-01-01

    Desde su descubrimiento, la polémica en torno al estatus de Homo floresiensis no ha cesado. ¿Son humanos de nuestra propia especie, pero que eran pigmeos que padecieron enanismo, microcefalia y otra serie de patologías, o se trata de miembros de una especie distinta a la nuestra? El hallazgo de restos pertenecientes a 13 individuos y el estudio de varias partes de su esqueleto avalan la segunda hipótesis.

  2. Homo floresiensis. Humanos distintos a nosotros.

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Marmelada

    2008-08-01

    Full Text Available Desde su descubrimiento, la polémica en torno al estatus de Homo floresiensis no ha cesado. ¿Son humanos de nuestra propia especie, pero que eran pigmeos que padecieron enanismo, microcefalia y otra serie de patologías, o se trata de miembros de una especie distinta a la nuestra? El hallazgo de restos pertenecientes a 13 individuos y el estudio de varias partes de su esqueleto avalan la segunda hipótesis.

  3. Duración y tiempo humano.

    OpenAIRE

    González-Umeres, L. (Luz)

    2002-01-01

    Este trabajo presenta dos visiones del tiempo humano: las de Bergson y Polo. La propuesta bergsoniana está fechada en París, 1888, en un ambiente mecanicista al cual se enfrenta, recuperando el tiempo psicológico. La propuesta de Polo iniciada a mediados del siglo XX va más allá del nivel psicológico: se adentra en el ámbito de los trascendentales personales.

  4. POBREZA, RECURSOS HUMANOS Y DESARROLLO SOSTENIBLE

    Directory of Open Access Journals (Sweden)

    Jorge Mora Alfaro

    2011-09-01

    Full Text Available Dos desafíos de enorme trascendencia enfrentan América Latina y el Caribe al arribar al siglo XXI: por un lado, crear las condiciones apropiadas para insertarse con éxito en el interconectado, competitivo y exigente mundo contemporáneo. Por otro lado, superar los obstáculos al logro de la aspiración del desarrollo humano sostenible, entre los que sobresale la ausencia de mecanismos eficaces de distribución del ingreso y la significativa cantidad de seres humanos sumidos en la pobreza y las privaciones.Estas dos dimensiones del desarrollo regional se encuentran estrechamente entrelazadas y mutuamente condicionadas. Una distribución más equitativa del ingreso contribuye a elevar la movilidad social, el acceso a la educación, el aumento de la productividad y la estabilidad, aspectos esenciales para acrecentar la capacidad competitiva y para lograr una inserción de calidad en el contexto internacional. Una estrategia de integración en el contexto internacional, sustentada en las fortalezas nacionales, en la identidad cultural y en el capital humano, posibilita la sostenibilidad y la distribución de los beneficios entre los diversos estratos de la sociedad.

  5. Flujos migratorios y movilidad del capital humano

    Directory of Open Access Journals (Sweden)

    Bernardí Cabrer

    2009-11-01

    Full Text Available En este trabajo se estiman los flujos migratorios de capital humano entre las regiones españolas a partir de un conjunto de hipótesis. Los resultados indican un aumento de la intensidad de los flujos brutos de migrantes con niveles de instrucción de 2° y 3er grado. Se constata que en España existen tres polos de atracción y emisión de capital humano centrados en Madrid, País Vasco y Cataluña, y actuando de forma independiente. Asimismo, se obtiene un grado de adecuación apreciable entre el nivel educativo de los inmigrantes y los requerimientos de cualificación de la mano de obra de cada región. Sin embargo, se obtiene que los años medios de estudio de la población potencialmente activa han aumentado frente a la estabilidad de los de la población migrante, por lo que no cabe señalar la inmigración como un factor relevante para reducir las disparidades interregionales en capital humano.

  6. Flujos migratorios y movilidad del capital humano

    Directory of Open Access Journals (Sweden)

    Bernardí Cabrer

    2009-01-01

    Full Text Available En este trabajo se estiman los flujos migratorios de capital humano entre las regiones españolas a partir de un conjunto de hipótesis. Los resultados indican un aumento de la intensidad de los flujos brutos de migrantes con niveles de instrucción de 2° y 3er grado. Se constata que en España existen tres polos de atracción y emisión de capital humano centrados en Madrid, País Vasco y Cataluña, y actuando de forma independiente. Asimismo, se obtiene un grado de adecuación apreciable entre el nivel educativo de los inmigrantes y los requerimientos de cualificación de la mano de obra de cada región. Sin embargo, se obtiene que los años medios de estudio de la población potencialmente activa han aumentado frente a la estabilidad de los de la población migrante, por lo que no cabe señalar la inmigración como un factor relevante para reducir las disparidades interregionales en capital humano.

  7. Obligaciones morales con seres no humanos

    Directory of Open Access Journals (Sweden)

    Rodrigo J. Ocampo

    2014-06-01

    Full Text Available Entre los modelos de reflexión ética a partir de los cuales es posible dar cuenta del debate sobre las relaciones entre seres humanos y no humanos están: el deontológico, el contractualista, el utilitarista, el neoaristotélico y el discursivo. En este artículo se examinará, a partir de ellos, la cuestión del estatus moral asignado a los animales y a la naturaleza, junto con la posibilidad de cada uno para sustentar la ampliación de las obligaciones morales. Para tal fin, se estudian los principales argumentos para reconocer o negar consideración moral a seres no humanos, así como los alcances de estas justificaciones para comprender el sentido y límites de la comunidad ética. Esto permitirá clasificar los enfoques éticos mencionados atendiendo a sus afinidades con diversas formas de antropocentrismo o biocentrismo.

  8. La época del talento humano

    Directory of Open Access Journals (Sweden)

    Mónica Murillo de Pisco

    2017-08-01

    Full Text Available "El  valor humano e  el  recurso más valioso  con  el  que  cuenta  toda organización", con  esta  frase  se inicia un comercial de televisión. el mismo  pretende promocionar  un seminario de Recursos Humanos en una de  las  principales ciudades del país,  la frase menciona lo que todos conocemos y palpamos  a diario en nuestros trabajos. pues la 'Adminis­ tración del Talento', es un tema que se  repite de manera permanente en las  conversaciones  de  los  profe­ sionales  de  RRHI 1,  y  de  forma rápida se convierte en el plato fuerte de  casi  todas  las  jornadas, seminarios  y  cursos  a  los  que asistimos:  el  Talento.  se  convierte entonces en  la  principal  herra­ mienta de todo buen administrador de  recursos  humanos  y  una estrategia primordial  para todas las organizaciones.

  9. Emerging targeted therapies for melanoma.

    Science.gov (United States)

    Johnson, Douglas B; Pollack, Megan H; Sosman, Jeffrey A

    2016-06-01

    Melanoma is an aggressive cutaneous malignancy associated with poor response to traditional therapies. Recent regulatory approval for immune checkpoint inhibitors and agents targeting mutated BRAF has led to a tremendous expansion of effective treatment options for patients with advanced melanoma. Unfortunately, primary or acquired resistance develops in most patients, highlighting the need for additional therapies. Numerous genetic and other molecular features of this disease may provide effective targets for therapy development. This article reviews available melanoma treatments, including immune and molecularly-targeted therapies. We then discuss agents in development, with a focus on targeted (rather than immune) therapies. In particular, we discuss agents that block mitogen-activated protein kinase (MAPK) signaling, as well as other emerging approaches such as antibody-drug conjugates, cell-cycle targeting, and novel genetically-informed clinical trials. Despite the incredible advances in melanoma therapeutics over the last several years, a clear need to develop more effective therapies remains. Molecularly-targeted therapy approaches will likely remain a cornerstone of melanoma treatment in parallel to immune therapy strategies.

  10. Current systemic therapies for melanoma.

    Science.gov (United States)

    Palathinkal, Darren M; Sharma, Timmie R; Koon, Henry B; Bordeaux, Jeremy S

    2014-09-01

    Systemic agents are used in melanoma for adjuvant therapy and to treat metastatic disease. Currently, interferon-α is the only agent approved for adjuvant therapy. Six drugs are FDA approved for metastatic disease: dacarbazine, interleukin-2 (IL-2), vemurafenib, ipilimumab, dabrafenib, and trametinib. Vemurafenib and ipilimumab were approved in 2011, whereas dabrafenib and trametinib were approved in 2013. This review will update the practicing dermatologist on the differences in efficacy, adverse events, and cost of systemic therapies available for the treatment of melanoma. This article is a review of the current literature on systemic therapies for advanced melanoma. Key search words included "advanced melanoma," "systemic therapy," and "adjuvant therapy" with particular focus on the past 20 years. Before 2011, dacarbazine and IL-2 were the only FDA approved therapies for metastatic melanoma, and IFN-α is the only approved agent for adjuvant therapy. The new agents vemurafenib, ipilimumab, dabrafenib, and trametinib are the first to have improved overall survival in Phase III studies in comparison with other systemic therapies. Despite new developments, there remains a significant need for better therapies with improved long-term efficacy and decreased toxicity.

  11. Other targeted drugs in melanoma.

    Science.gov (United States)

    González-Cao, María; Rodón, Jordi; Karachaliou, Niki; Sánchez, Jesús; Santarpia, Mariacarmela; Viteri, Santiago; Pilotto, Sara; Teixidó, Cristina; Riso, Aldo; Rosell, Rafael

    2015-10-01

    Targeted therapy drugs are developed against specific molecular alterations on cancer cells. Because they are "targeted" to the tumor, these therapies are more effective and better tolerated than conventional therapies such as chemotherapy. In the last decade, great advances have been made in understanding of melanoma biology and identification of molecular mechanisms involved in malignant transformation of cells. The identification of oncogenic mutated kinases involved in this process provides an opportunity for development of new target therapies. The dependence of melanoma on BRAF-mutant kinase has provided an opportunity for development of mutation-specific inhibitors with high activity and excellent tolerance that are now being used in clinical practice. This marked a new era in the treatment of metastatic melanoma and much research is now ongoing to identify other "druggable" kinases and transduction signaling networking. It is expected that in the near future the spectrum of target drugs for melanoma treatment will increase. Herein, we review the most relevant potential novel drugs for melanoma treatment based on preclinical data and the results of early clinical trials.

  12. Melanoma stem cells in experimental melanoma are killed by radioimmunotherapy

    International Nuclear Information System (INIS)

    Jandl, Thomas; Revskaya, Ekaterina; Jiang, Zewei; Harris, Matthew; Dorokhova, Olena; Tsukrov, Dina; Casadevall, Arturo; Dadachova, Ekaterina

    2013-01-01

    Introduction: In spite of recently approved B-RAF inhibitors and immunomodulating antibodies, metastatic melanoma has poor prognosis and novel treatments are needed. Melanoma stem cells (MSC) have been implicated in the resistance of this tumor to chemotherapy. Recently we demonstrated in a Phase I clinical trial in patients with metastatic melanoma that radioimmunotherapy (RIT) with 188-Rhenium( 188 Re)-6D2 antibody to melanin was a safe and effective modality. Here we investigated the interaction of MSC with RIT as a possible mechanism for RIT efficacy. Methods: Mice bearing A2058 melanoma xenografts were treated with either 1.5 mCi 188 Re-6D2 antibody, saline, unlabeled 6D2 antibody or 188 Re-labeled non-specific IgM. Results: On Day 28 post-treatment the tumor size in the RIT group was 4-times less than in controls (P < 0.001). The tumors were analyzed by immunohistochemistry and FACS for two MSC markers — chemoresistance mediator ABCB5 and H3K4 demethylase JARID1B. There were no significant differences between RIT and control groups in percentage of ABCB5 or JARID1B-positive cells in the tumor population. Our results demonstrate that unlike chemotherapy, which kills tumor cells but leaves behind MSC leading to recurrence, RIT kills MSC at the same rate as the rest of tumor cells. Conclusions: These results have two main implications for melanoma treatment and possibly other cancers. First, the susceptibility of ABCB5 + and JARID1B + cells to RIT in melanoma might be indicative of their susceptibility to antibody-targeted radiation in other cancers where they are present as well. Second, specifically targeting cancer stem cells with radiolabeled antibodies to ABCB5 or JARID1B might help to completely eradicate cancer stem cells in various cancers

  13. High accuracy of family history of melanoma in Danish melanoma cases.

    Science.gov (United States)

    Wadt, Karin A W; Drzewiecki, Krzysztof T; Gerdes, Anne-Marie

    2015-12-01

    The incidence of melanoma in Denmark has immensely increased over the last 10 years making Denmark a high risk country for melanoma. In the last two decades multiple public campaigns have sought to increase the awareness of melanoma. Family history of melanoma is a known major risk factor but previous studies have shown that self-reported family history of melanoma is highly inaccurate. These studies are 15 years old and we wanted to examine if a higher awareness of melanoma has increased the accuracy of self-reported family history of melanoma. We examined the family history of 181 melanoma probands who reported 199 cases of melanoma in relatives, of which 135 cases where in first degree relatives. We confirmed the diagnosis of melanoma in 77% of all relatives, and in 83% of first degree relatives. In 181 probands we validated the negative family history of melanoma in 748 first degree relatives and found only 1 case of melanoma which was not reported in a 3 case melanoma family. Melanoma patients in Denmark report family history of melanoma in first and second degree relatives with a high level of accuracy with a true positive predictive value between 77 and 87%. In 99% of probands reporting a negative family history of melanoma in first degree relatives this information is correct. In clinical practice we recommend that melanoma diagnosis in relatives should be verified if possible, but even unverified reported melanoma cases in relatives should be included in the indication of genetic testing and assessment of melanoma risk in the family.

  14. INCIDENCIA DE LAS POLÍTICAS DE RECURSOS HUMANOS EN LA TRANSFERENCIA DE CONOCIMIENTO Y SU EFECTO SOBRE LA INNOVACIÓN

    Directory of Open Access Journals (Sweden)

    García-Pintos Escuder, A.

    2010-01-01

    Full Text Available El presente trabajo se centra en la transferencia de conocimiento, la cual es un área muy importante de la gestión del conocimiento. El propósito del presente trabajo es identificar aquellas prácticas de recursos humanos que pueden fomentar el que los trabajadores compartan su conocimiento. Para ello, a nivel teórico se identifican aquellas prácticas que facilitan y fomentan este proceso. Además, dado que la innovación depende de la disponibilidad de conocimiento, el presente trabajo trata de clarificar el papel que tiene la transferencia de conocimiento en la innovación. A través del análisis de 242 encuestas dirigidas a directores de recursos humanos, se contrastan empíricamente las hipótesis planteadas.

  15. Cooperación internacional de las naciones unidas al plan nacional de educación en derechos humanos (planedh) en Colombia, (2004 - 2012)

    OpenAIRE

    Romero Murillo, María Alejandra

    2014-01-01

    El interés de este estudio de caso es analizar el papel de la cooperación internacional de la Oficina del Alto Comisionado de las Naciones Unidas (OACNUDH) en la implementación del Plan Nacional de Educación en Derechos Humanos (PLANEDH) como política pública en Colombia. El análisis conducirá a la importancia del apoyo de la OACNUDH en el proceso de consolidación del PLANEDH como política pública y como estrategia para garantizar la promoción, protección y ejecución de los derechos humanos. ...

  16. Dilemas e desafios da Proteção Internacional dos Direitos Humanos no limiar do século XXI

    Directory of Open Access Journals (Sweden)

    Antônio Augusto Cançado Trindade

    1997-06-01

    Full Text Available Balanço dos avanços conceituais e práticos e das limitações ainda existentes, de ordem legal ou política, à proteção universal dos direitos humanos, ressaltando a construção progressiva dos instrumentos disponíveis - as convenções centrais - e o papel das conferências e das cortes regionais de defesa dos direitos humanos.Review of the conceptual and practical progresses and the restrictions that still exists, of legal or political order, to the universal protection of human rights, emphasizing the progressive building of the available instruments - the central conventions and the role of the conferences and regional courts of human rights defense.

  17. Clear cells in acral melanoma.

    Science.gov (United States)

    Schmuth, M; Spötl, L; Zelger, B; Weinlich, G; Zelger, B

    2001-01-01

    Acral melanoma may present clinically and histologically with atypical features causing a delay in proper diagnosis. The aim of the present study was to assess the frequency of a histological variant with clear cell changes. Clinical information, hematoxylin & eosin stained paraffin sections and immunohistochemical staining profiles were reviewed in 49 cases of acral melanoma. Twenty-one (43%) specimens contained tumor cells with clear cell changes in focal areas, whereas in 7 (14%) specimens clear cells were the major tumor constituting cells. The tumor thickness ranged from melanoma in situ to 14 mm. Immunohistochemistry demonstrated weak staining for S100 and HMB45 as well as strong positivity for Melan A and NK1C3. Recognition of clear cell features is important since differential diagnosis includes a variety of other clear cell malignancies, among them metastasis from renal cell carcinoma, clear cell sarcoma and hidradenocarcinoma.

  18. Communication Among Melanoma Family Members

    Science.gov (United States)

    Bowen, Deborah J; Albrecht, Terrance; Hay, Jennifer; Eggly, Susan; Harris-Wei, Julie; Meischke, Hendrika; Burke, Wylie

    2017-01-01

    Interventions to improve communication among family members may facilitate information flow about familial risk and preventive health behaviors. This is a secondary analysis of the effects of an interactive website intervention aimed at increasing communication frequency and agreement about health risk among melanoma families. Participants were family units, consisting of one family member with melanoma identified from a previous research study (the case) and an additional first degree relative and a parent of a child 0–17. Family triads were randomized to receive access to the website intervention or to serve as control families. Family communication frequency and agreement about melanoma prevention behaviors and beliefs were measured at baseline and again at one year post randomization. Intervention participants of all three types significantly increased the frequency of communication to their first degree relatives (Parents, siblings, children; range =14–18 percentage points; all pcommunication about cancer risk. PMID:28248624

  19. Genetic alterations and markers of melanoma

    Directory of Open Access Journals (Sweden)

    N. N. Mazurenko

    2014-01-01

    Full Text Available Melanoma remains the most deadly form of malignant skin disease with high risk of metastases. Metastatic melanoma is prognostic highly unfavorable and resistant to traditional chemotherapy and biologic treatment. There is a great progress in understanding of the molecular mechanisms underlying melanoma initiation and progression. The external (ultraviolet irradiation and internal (genetic factors are involved in melanoma genesis. 5–14 % of melanoma cases occur in familial context due to genetic predisposition risk factors. Among them rare germinal mutations in the cell cycle genes regulators CDKN2A and CDK4 and in the master gene of melanocyte homeostasis MITF, as well as single nucleotide polymorphisms of several low-penetrated genes, namely MC1R, have been identified. The main cell signaling pathways and oncogene driver mutations are involved in melanoma pathogenesis. RAS / RAF / MEK / ERK cascade is hyperactivated in 75 % of cutaneous melanoma cases. Activation of PI3K / AKT / mTOR signaling pathway is important for melanoma progression. Recent studies revealed that melanomas are genetically and phenotypically heterogeneous tumors. Spectrum of chromosomal alterations and activating mutations corresponding to tumor molecular portraits varies in melanomas of different location. Most of cutaneous melanomas contain BRAF (50 % or NRAS (20 % mutations, and NRAS mutations occur on chronically sun-exposed skin. Activating KIT mutations have been reported in approximately 20–30 % of certain subtypes of melanoma, including acral and mucosal, and melanoma that develop on photodamaged skin. Cutaneous metastatic melanoma derive from preexisting nevi in 25 % of cases, molecular mechanisms of nevi malignization are discussed. Deepsequencing approaches of melanoma samples of different melanoma types highlighted new melanoma driver genes, that are damaged due to tumorigenic effects of ultraviolet: PPP6C, RAC1, SNX31, TACC1 and STK19. The

  20. Familial skin cancer syndromes: Increased melanoma risk.

    Science.gov (United States)

    Ransohoff, Katherine J; Jaju, Prajakta D; Jaju, Prajaka D; Tang, Jean Y; Carbone, Michele; Leachman, Sancy; Sarin, Kavita Y

    2016-03-01

    Phenotypic traits, such as red hair and freckling, increase melanoma risk by 2- to 3-fold. In addition, approximately 10% of melanomas are caused by inherited germline mutations that increase melanoma risk from 4- to >1000-fold. This review highlights the key genes responsible for inherited melanoma, with an emphasis on when a patient should undergo genetic testing. Many genetic syndromes associated with increased melanoma risk are also associated with an increased risk of other cancers. Identification of these high-risk patients is essential for preventive behavior reinforcement, genetic counseling, and ensuring other required cancer screenings. Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  1. Melanoma: oncogenic drivers and the immune system.

    Science.gov (United States)

    Karachaliou, Niki; Pilotto, Sara; Teixidó, Cristina; Viteri, Santiago; González-Cao, María; Riso, Aldo; Morales-Espinosa, Daniela; Molina, Miguel Angel; Chaib, Imane; Santarpia, Mariacarmela; Richardet, Eduardo; Bria, Emilio; Rosell, Rafael

    2015-10-01

    Advances and in-depth understanding of the biology of melanoma over the past 30 years have contributed to a change in the consideration of melanoma as one of the most therapy-resistant malignancies. The finding that oncogenic BRAF mutations drive tumor growth in up to 50% of melanomas led to a molecular therapy revolution for unresectable and metastatic disease. Moving beyond BRAF, inactivation of immune regulatory checkpoints that limit T cell responses to melanoma has provided targets for cancer immunotherapy. In this review, we discuss the molecular biology of melanoma and we focus on the recent advances of molecularly targeted and immunotherapeutic approaches.

  2. El doble ajuste de la estrategia de recursos humanos: Las percepciones de los trabajadores como nexo entre las políticas formuladas e implantadas

    Directory of Open Access Journals (Sweden)

    Natalia García Carbonell

    2013-12-01

    Full Text Available Objeto: Partiendo de los resultados inconsistentes que la literatura ha mostrado acerca de la relación entre el rendimiento organizativo y la dirección de recursos humanos, este estudio discute la asociación entre ambas variables desde una perspectiva de proceso. Para ello, diferenciaremos entre el doble ajuste definido (vertical y horizontal y el realmente alcanzado en la etapa de implantación de las prácticas.Diseño/metodología: La investigación presenta una revisión teórica de varios campos de la literatura en materia de dirección de recursos humanos (perspectiva del doble ajuste y la fortaleza del sistema de gestión.Aportaciones y resultados: el artículo concluye con la propuesta de un modelo teórico alternativo que explica la relación entre la función de recursos humanos y en desempeño organizativo, introduciendo las percepciones de los empleados acerca del sistema de gestión como variable mediadora.Implicaciones prácticas: Las conclusiones apuntan a la importancia de la comunicación organizativa en los procesos de RRHH, el papel del responsable de recursos humanos y el uso de la fortaleza del sistema de gestión como una herramienta de evaluación del ajuste de la estrategia implantada.Valor añadido: Este estudio contribuye a explicar los efectos de la estrategia de recursos humanos sobre los resultados organizativos poniendo énfasis en tres aspectos: (1 la consideración las percepciones de los trabajadores acerca del sistema de gestión de recursos humanos como una variable mediadora entre las estrategias de recursos humanos y el rendimiento, (2 la integración en un mismo estudio de las fases de formulación e implantación de la estrategia de recursos humanos y, (3 la introducción del constructo fortaleza del sistema de gestión de recursos humanos como una herramienta de valoración del ajuste vertical y horizontal en la fase de implantación.

  3. Capital humano y capacidades societales de condiciones para el desarrollo de las empresas de producción social en Venezuela

    OpenAIRE

    Colina Arenas, Belinda

    2009-01-01

    El objetivo es destacar la importancia del capital humano para el desarrollo de Capacidades Societales de Innovación CSI en Empresas de Producción Social EPS a través de la instauración de una cultura innovadora, bajo la convicción del papel protagónico que debe asumir el mismo en el desarrollo y consolidación de estas. Las EPS surgen en el marco del Registro de Empresas de Producción Social REPS, creado en noviembre de 2005 inserto en el Programa de Empresas de Producción Social, amparado en...

  4. Pedagogía para la sostenibilidad basada en la recuperación de tres vínculos: vital, humano y natural

    OpenAIRE

    Moreno Yus, María Ángeles

    2007-01-01

    La finalidad de este artículo es la de proponer una reflexión sobre el papel de la educación para la sostenibilidad, desde las premisas de un pensamiento humanista y naturalista del mundo como base para comprender las claves de la vida en nuestro planeta. Un pensamiento capaz de fortalecer los vínculos existentes del ser humano con su medio desde un punto de vista global e interdisciplinar. Estos aspectos son tomados en consideración en el primer punto. En el segundo y tercer punto se abo...

  5. Derechos fundamentales y derechos humanos en Costa Rica. Alcances particulares en relación con los derechos de las personas con VIH

    OpenAIRE

    Badilla, Ana Elena

    2007-01-01

    El marco constitucional y legal de Costa Rica, incluida la jurisprudencia de la Sala Constitucional de la Corte Suprema de Justicia, es fiel garante de los derechos humanos. Además, la existencia de un amplio marco jurídico internacional vigente en el país sobre protección de tales derechos contribuye a llenar las lagunas que presenta la legislación nacional. Particularmente destacable ha sido el papel jugado por la citada Sala Constitucional en la defensa de los derechos hu...

  6. Para una Crítica de Las Críticas Al Discurso de Los Derechos Humanos y Fundamentales: De La Desconstrucción Del Jushumanismo Hacia El Jushumanismo Crítico

    Directory of Open Access Journals (Sweden)

    Saulo De Oliveira Pinto Coelho

    2015-12-01

    Full Text Available Esta investigación tiene como principal objeto de analisis y reflexión el fenómeno de los discursos de crítica al rol fundamental que tienen los derechos humano-fundamentales en las actuales sociedades democráticas. El problema central de la investigación consiste en la pregunta por la consistencia de tales discursos y sobre la posibilidad de que se basen en estratagemas y falacias. Como presupuesto investigativo está el planteamiento de que existen dos tipos básicos de discursos sobre os derechos humanos que hay que sospechar: la perspectiva apologética, de una parte, y la perspectiva de se puede llamar de critica-niilista, de otra. Hay que sumar a esto la hipótesis de que: el discurso que puede cajear contribuciones a las actuales sociedades democráticas es el que está basado en una reflexión criticopropositiva sobre os derechos humanos. La hipótesis -la falacia de algunos discursos críticos sobre los derechos humanos- la hemos testado por medio de la realización de un inventario de los modelos heurísticos básicos de dos discursos críticos de los derechos humanos. Como resultado de la investigación, ha sido posible la identificación de seis modelos heurísticos de critica a los derechos humanos, de los cuales cinco han sido desvelados en sus falacias e uno, relativos a los problemas del lenguaje principiológico de los derechos humanos, ha sido confirmado como consistente. Pese a los difíciles desafíos de la experiencia de los derechos humano-fundamentales, cumplen un papel indispensable y insustituible, de momento, en las sociedades democráticas contemporáneas.

  7. Choroidal melanoma in a dog.

    Science.gov (United States)

    Miwa, Yasutsugu; Matsunaga, Satoru; Kato, Kumiko; Ogawa, Hiroyuki; Nakayama, Hiroyuki; Tsujimoto, Saori; Sasaki, Nobuo

    2005-08-01

    A 7-year-old intact female golden Retriever was referred for evaluation of an intraorbital mass of the left eye. Based on ophthalmoscopy, ultrasonography and magnetic resonance imaging (MRI), the tentative diagnosis was made as an intraocular neoplasia, especially choroidal melanoma. The orbital exenteration of the affected eye was performed. The mass was histologically diagnosed as malignant choroidal melanoma. No signs of recurrence and metastasis were detected by thoracic radiographs, blood examinations and MR images, and the dog was clinically healthy for 23 months after operation.

  8. Oral mucosal melanoma: A case report

    Directory of Open Access Journals (Sweden)

    Ramlal Gantala

    2017-01-01

    Full Text Available Malignant melanoma is most deadly of all primary skin cancers. Over 90% of melanomas occur on the skin. Half of such melanomas occur in the oral cavity, followed by nasal cavity (44% and sinuses (8%. In the oral cavity, the most frequent sites of occurrence are hard palate and maxillary gingiva. Mucosal melanomas represent a diagnostic challenge than the more common cutaneous melanomas because oral melanomas demonstrate significant heterogeneity in morphological features, developmental process, and biological behaviour. This case report highlights an exophytic, lobulated oral malignant melanoma involving maxillary gingiva and is presented to reemphasize the fact that any pigmented lesion in the oral cavity should be examined with suspicion; proper investigation should be carried out to rule out any untoward experiences later.

  9. ¿Qué son los derechos humanos?

    Directory of Open Access Journals (Sweden)

    Daniel Raffo

    2015-01-01

    Full Text Available Sobre los Derechos humanos se habló pasada la Segunda Guerra Mundial. El autor da varias definiciones y se enfatiza en que son derechos inherentes a la persona humana, derechos naturales del hombre, derechos fundamentales, son parte de la misma cosa: Defender al ser humano del ser humano.Precisa tres corrientes: la absolutista, la subjetivista y la relativa. Educar y concienciar es la tarea y en esto los medios de comunicación tienen su labor.

  10. DERECHOS HUMANOS Y VIVIR BIEN / BUEN VIVIR

    Directory of Open Access Journals (Sweden)

    Adalid Contreras Baspineiro

    2017-03-01

    Full Text Available La cosmovisión del Vivir Bien / Buen Vivir es, en su naturaleza y en su constitución, una expresión anticipatoria de la formulación sistematizada de los Derechos Humanos integrales; en realidad construir la sociedad del Vivir Bien/Buen Vivir es construir una sociedad de plena vigencia de los derechos humanos y de los derechos de la naturaleza. El presente artículo tiene el propósito de mostrar esta interdependencia a partir del análisis crítico sobre su realización en dos campos políticos[1]: el comunitario y el estatal. El campo político comunitario teje articulaciones entre una cosmovisión originada en los pueblos indígenas, las reivindicaciones de grupos ciudadanos por la exigibilidad de los derechos humanos, y la doctrina social de la Iglesia que vela por el bien común. El campo político estatal se expresa en el impulso de un nuevo constitucionalismo basado en los derechos y en políticas nacionales de desarrollo para el Vivir Bien / Buen Vivir. [1] Siguiendo a Bourdieu, reconocemos que el campo político articula un nivel de acción ideológica y estratégica relacionada con la hegemonía del poder, otro institucional en el que se identifican los actores políticos, y un tercero en el que se definen los principios y normas.

  11. O uso das plantas medicinais e o papel da fé no cuidado familiar

    Directory of Open Access Journals (Sweden)

    Crislaine Alves Barcellos de Lima

    2017-05-01

    Full Text Available RESUMO Objetivo Compreender o uso das plantas medicinais e o papel da fé no sistema de cuidado familiar. Método Pesquisa qualitativa, realizada em abril e julho de 2015, em um município do Rio Grande do Sul/Brasil, com três informantes conhecedores de práticas de cuidado. A interpretação dos dados seguiu referencial antropológico interpretativo. Resultados Emergiram duas categorias: Plantas medicinais no cuidado à saúde e Cuidado com o uso das plantas no ritual de benzer. Identificou-se que o uso das plantas e a cura pela fé constituem uma forma de autoatenção peculiar, própria do território, que resgata o ser humano da perspectiva biológica e íntegra corpo, alma, espírito e ambiente. Conclusão A investigação permitiu compreender que as plantas medicinais, além da relação biológica estabelecida, atuam no sistema de cuidado familiar, sendo que a sua utilização não opera conforme os princípios de compra e venda, mas da troca, do dar, receber e retribuir.

  12. O DIREITO HUMANO AO ACESSO À INTERNET

    Directory of Open Access Journals (Sweden)

    Manuel Martín Pino Estrada

    2015-12-01

    Full Text Available O acesso à internet tornou-se essencial na vida das pessoas. Estas podem manifestar as suas ideias, fazer denúncias, colocar vídeos, postar imagens, procurar emprego, fazer amizades, convocar protestos, incentivar grupos para atividades diversas, mobilizar gente em prol de reivindicação de direitos, assim como para conquistá-los, pedir ajuda, estudar e adquirir conhecimento, dentre outras atividades afins. Então, ao tornar-se tão importante, tornou-se também um direito humano, que não pode ser mais retirado da rede.

  13. Pobreza, capital humano, capital social e familiar

    OpenAIRE

    Petrini, Giancarlo; Fonseca, Ricardo; Porreca, Wladimir

    2010-01-01

    O presente estudo investiga a pobreza partindo de uma análise dos recursos que os pobres dispõem em sua realidade, analisando os temas do capital humano, social e familiar, procurando estabelecer conexões e elucidar fatores da realidade pouco considerados em estudos e  projetos de combate à pobreza e à exclusão social. O presente artigo, em seu conjunto, procura compreender porque, em condições semelhantes de pobreza, algumas pessoas conseguem elaborar um projeto de vida enquanto outras se es...

  14. Prostitución y derechos humanos

    Directory of Open Access Journals (Sweden)

    Daniela Heim

    2011-06-01

    Full Text Available RESUMEN Este artículo analiza las principales contribuciones de los movimientos feministas de cara a la comprensión del complejo fenómeno de la prostitución y sus diferentes estrategias en orden a la vindicación, reconocimiento y protección de los derechos humanos de las mujeres insertadas en esta actividad.   ABSTRACT This article analyzes the main contributions of the feminist movements in order to understand the complex phenomenon of the prostitution and its different strategies of vindication, recognition and protection of the human rights of women inserted in this activity.

  15. Servicios públicos y derechos humanos

    OpenAIRE

    Cabello, Julia

    2004-01-01

    Cuando se habla o se escribe sobre los Derechos Humanos en el Perú, casi siempre el imaginario colectivo se traslada a las imágenes de torturas, asesinatos y desapariciones de pobladores y dirigentes sindicales y populares que se dieron en los diferentes gobiernos de turno; y que se recrudeciera en la década de los 90 en el nefasto régimen del Gobierno corrupto de Alberto Fujimori. Sin embargo, en el Perú como en toda América Latina, no solo los derechos civiles y políticos son vulnerado...

  16. La anatomia del cuerpo humano: exposicion temporal

    OpenAIRE

    Antommarchi, Francesco

    2013-01-01

    El cuerpo humano representado en la obra de Paolo Mascagni y posteriormente en la de Antommarchi, plasma en detalle la totalidad de los órganos del cuerpo como el anatomista los podía ver en un cadáver: desde la capa superficial subyacente a los tegumentos comunes, hasta el esqueleto; la red subcutánea formada por los nervios y los vasos sanguíneos superficiales, todos los planos musculares con los nervios, los vasos sanguíneos y los vasos linfáticos; en fin, los órganos que componen las tres...

  17. Cutavirus in Cutaneous Malignant Melanoma

    DEFF Research Database (Denmark)

    Mollerup, Sarah; Fridholm, Helena; Vinner, Lasse

    2017-01-01

    A novel human protoparvovirus related to human bufavirus and preliminarily named cutavirus has been discovered. We detected cutavirus in a sample of cutaneous malignant melanoma by using viral enrichment and high-throughput sequencing. The role of cutaviruses in cutaneous cancers remains...

  18. Prognostic stratification of ulcerated melanoma

    DEFF Research Database (Denmark)

    Bønnelykke-Behrndtz, Marie L; Schmidt, Henrik; Christensen, Ib J

    2014-01-01

    OBJECTIVES: For patients with melanoma, ulceration is an important prognostic marker and interestingly also a predictive marker for the response of adjuvant interferon. A consensual definition and accurate assessment of ulceration are therefore crucial for proper staging and clinical management. We...

  19. Stages of Intraocular (Uveal) Melanoma

    Science.gov (United States)

    ... or tans poorly. Blue or green or other light-colored eyes. Older age. Being white. Signs of intraocular melanoma include blurred vision ... to treat small tumors. This is also called light coagulation. ... are being tested in clinical trials. Information about clinical trials ...

  20. Prognostic Factors in Uveal Melanoma

    NARCIS (Netherlands)

    E. Kiliç (Emine)

    2006-01-01

    textabstractUveal melanoma is the most common intra-ocular tumour in the western world with an annual incidence of seven per million. Approximately 50% of the patients treated by enucleation dye eventually due to metastatic disease. Besides enucleation there are nowadays more conservative treatment

  1. Pediatric melanoma: incidence, treatment, and prognosis

    Directory of Open Access Journals (Sweden)

    Saiyed FK

    2017-04-01

    Full Text Available Faiez K Saiyed,1 Emma C Hamilton,1 Mary T Austin,1,2 1Department of Pediatric Surgery, McGovern Medical School, 2Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Abstract: The purpose of this review is to outline recent advancements in diagnosis, treatment, and prevention of pediatric melanoma. Despite the recent decline in incidence, it continues to be the deadliest form of skin cancer in children and adolescents. Pediatric melanoma presents differently from adult melanoma; thus, the traditional asymmetry, border irregularity, color variegation, diameter >6 mm, and evolution (ABCDE criteria have been modified to include features unique to pediatric melanoma (amelanotic, bleeding/bump, color uniformity, de novo/any diameter, evolution of mole. Surgical and medical management of pediatric melanoma continues to derive guidelines from adult melanoma treatment. However, more drug trials are being conducted to determine the specific impact of drug combinations on pediatric patients. Alongside medical and surgical treatment, prevention is a central component of battling the incidence, as ultraviolet (UV-related mutations play a central role in the vast majority of pediatric melanoma cases. Aggressive prevention measures targeting sun safety and tanning bed usage have shown positive sun-safety behavior trends, as well as the potential to decrease melanomas that manifest later in life. As research into the field of pediatric melanoma continues to expand, a prevention paradigm needs to continue on a community-wide level. Keywords: melanoma, pediatric, adolescent, childhood

  2. Guideline on the Management of Melanoma | Board | South African ...

    African Journals Online (AJOL)

    Validation. Melanoma management involves many medical specialties. Guidelines should therefore be developed through a multidisciplinary consensus. The Melanoma Advisory Board consists of a forum of dermatologists, oncologists, plastic surgeons and pathologists. Guideline sponsor. The meetings of the Melanoma ...

  3. Mucosal malignant melanoma - a clinical, oncological, pathological and genetic survey

    DEFF Research Database (Denmark)

    Mikkelsen, Lauge H; Larsen, Ann-Cathrine; von Buchwald, Christian

    2016-01-01

    Mucosal melanomas constitute 1.3% of all melanomas and they may develop in any mucosal membrane. Conjunctival melanomas (0.5/million/year) and melanomas in the sinonasal cavity (0.5/million/year) are the most common, followed by anorectal melanomas (0.4/million/year) and melanomas in the oral...... cavity (0.2/million/year). Anorectal melanoma occurs slightly more often in females, whereas oral melanoma has a male predilection. Mucosal melanoma most commonly develops in a patient's sixth or seventh decade of life, and no differences between races have been found except for sinonasal melanoma...... is the treatment of choice. The prognosis is poor, with the 5-year survival rate ranging from 0% (gastric melanoma) to 80% (conjunctival melanoma)....

  4. Risk factors for second primary melanoma among Dutch patients with melanoma

    NARCIS (Netherlands)

    Schuurman, M.S.; Waal, A.C. de; Thijs, E.J.M.; Rossum, M.M. van; Kiemeney, L.A.L.M.; Aben, K.K.H.

    2017-01-01

    BACKGROUND: Patients with melanoma are at increased risk of developing subsequent primary melanomas. Knowledge about risk factors for these subsequent primaries is scarce. More evidence may help clinicians in tailoring surveillance schedules by selecting patients who could benefit from intensified

  5. CAPITAL HUMANO Y E-RRHH

    Directory of Open Access Journals (Sweden)

    Carlos Ramón López Paz

    2007-05-01

    Full Text Available

    Se expresan consideraciones acerca de la necesidad de la integración de concepciones y técnicas sobre el tratamiento del capital humano y el capital intelectual, con concepciones y técnicas relativas a las nuevas tecnologías de la información y las comunicaciones (NTIC, para el logro de e-RRHH, destacando entre estas últimas los

    data warehouses y data mining. Al gestor de recursos humanos de esta contemporaneidad corresponde desarrollar las acciones pertinentes, o tendrá que renunciar a tal gestión.

  6. Charles Darwin: um observador do desenvolvimento humano

    Directory of Open Access Journals (Sweden)

    Eloisa Helena Rubello Valler Celeri

    2010-12-01

    Full Text Available Os autores traduzem, pela primeira vez para o português, o artigo de Charles Darwin "A Biographical Sketch of an Infant", publicado no periódico Mind em julho de 1877. Utilizando anotações de observações do desenvolvimento de seus filhos, especialmente de seu filho mais velho William Erasmus (Doddy, Darwin descreve e estuda, a partir de seu enfoque naturalista, o filhote humano, narrando os primeiros indicativos comportamentais de emoções tais como raiva e medo, curiosidade e senso moral, o brincar e o prazer envolvido nesta atividade, a capacidade de imitação e os primeiros indícios daquilo que hoje conhecemos como "teoria da mente". Colocando-se questões sobre as capacidades do bebê, como eles aprendem e como se comunicam e levantando hipóteses sobre possíveis significados de certos comportamentos, questões ainda hoje fundamentais para o estudo do desenvolvimento humano, Darwin mostra-se também um pioneiro no estudo do bebê e da criança pequena, numa época na qual as capacidades dos bebês eram extremamente subestimadas e desconsideradas.

  7. Síntese da Relação da Tecnologia com o Ser Humano e a Sociedade Sintesis de la relación de la tecnologia con el ser humano y la sociedad

    Directory of Open Access Journals (Sweden)

    Johnny Virgil

    2008-09-01

    Full Text Available O mundo moderno está povoado de tecnologias e, dentre elas, existem as chamadas tecnologias de informação e comunicação. Este artigo sintetiza a relação das tecnologias, em especial das tecnologias de informação e comunicação, com o ser humano e a sociedade, por meio de uma revisão de literatura. Constatou-se que as tecnologias em geral exercem um papel condicionante e modificador em ambos. As tecnologias de informação e comunicação provavelmente deixarão neles marcas indeléveis.

  8. O papel da Radiologia em Odontologia Legal

    Directory of Open Access Journals (Sweden)

    GRUBER Jonas

    2001-01-01

    Full Text Available Vários métodos são empregados na identificação de restos humanos, sendo que a maioria é baseada na comparação entre dados ante-mortem e post-mortem disponíveis. Embora a técnica da impressão digital seja considerada a mais precisa, em muitos casos ela não pode ser utilizada, especialmente quando os corpos foram mutilados, decompostos, queimados ou fragmentados. Nestas situações, os métodos empregados pela Odontologia Legal tornam-se extremamente valiosos, uma vez que os dentes e as restaurações são muito resistentes à destruição pelo fogo, preservando numerosas características individuais. Assim, oferecem a possibilidade de uma identificação acurada e aceita pelas autoridades legais. Este breve artigo de revisão descreve os principais avanços alcançados pela Odontologia Legal, nos últimos 25 anos, quanto ao emprego de radiografias ante- e post-mortem no processo de identificação. Dentre os diversos assuntos tratados, destacam-se: suportes especialmente confeccionados para facilitar o posicionamento e a fixação de filmes radiológicos intra-orais em falecidos com rigor mortis; dispositivos para facilitar a reprodução da geometria de imagens com as de ante-mortem; métodos envolvendo radiografias digitalizadas, as quais podem ser facilmente manipuladas por métodos computacionais, armazenadas e transmitidas por "modem" aos locais de desastre em massa; procedimentos para determinação de idade, identificação de indivíduos desdentados por meio da comparação de radiografias oclusais do maxilar e estudos de validação de radiografias tiradas com intervalos ante- e post-mortem de até 30 anos.

  9. Falha a longo prazo no tratamento do melanoma de coróide com termoterapia transpupilar

    Directory of Open Access Journals (Sweden)

    Gabriela Soncini Pasetto

    2013-08-01

    Full Text Available OBJETIVO: Avaliar, retrospectivamente, num longo intervalo de tempo, os resultados da termoterapia transpupilar em casos selecionados do melanoma de coróide. MÉTODOS: Foram identificados todos os casos com melanoma de coróide tratados com termoterapia transpupilar, como terapia única ou suplementar. Foram excluídos os casos com seguimento inferior a 60 meses, prontuários incompletos ou com o abandono do acompanhamento. RESULTADOS: De um total de 18 olhos, 7 (38.9% foram incluídos no estudo. Cinco (71,4% pacientes foram tratados exclusivamente com termoterapia transpupilar, em 1 (14,2% olho a crioterapia foi simultânea, 1 (14,2% suplementou braquiterapia - placa episcleral. Três (42.8% sofreram recorrência, 2 (28.5% apresentaram metástases (um óbito, 2 foram enucleados. Complicações foram encontradas em 3 olhos: dobras maculares em 2, hemorragia vítrea em 1. Nos olhos enucleados, não havia extensão extraescleral, porém células interesclerais foram identificadas. CONCLUSÃO: Termoterapia transpupilar mostra um declínio em sua eficácia e conserva os riscos de metástases em períodos mais longos de acompanhamento, sendo necessária uma definição mais exata de seu papel nos melanomas de coróide.

  10. O objeto objeto na análise organizacional: a teoria ator-rede como método de análise da participação dos não-humanos no processo organizativo

    Directory of Open Access Journals (Sweden)

    César Tureta

    Full Text Available O objetivo deste artigo é analisar os objetos e elementos não-humanos como agentes constituintes do processo organizativo, por meio de uma abordagem pós-humanista: a teoria ator-rede. Considerando a crescente influência do pós-humanismo nas ciências humanas e, mais especificamente, na análise organizacional, desenvolvemos a idéia de aplicação do conceito de simetria, da teoria ator-rede, como uma lente de análise que permite investigar, simetricamente, humanos e não-humanos em práticas específicas no âmbito das organizações. Articulamos a noção de simetria com o desdobrar de práticas sociais, bem como o papel dos objetos e não-humanos nesse processo. Apresentamos e discutimos, a título de ilustração, alguns trabalhos que identificaram como os elementos materiais se fazem presentes e dão forma às atividades no cotidiano organizacional. Concluímos que a inclusão dos não-humanos na análise das organizações permite ampliar os horizontes de investigação, muito embora, o principal desafio talvez seja construir uma metodologia suficientemente capaz de apreender e observar esses elementos em seus contextos de atuação.

  11. LIBERDADE DE PESQUISA COMO DIREITO HUMANO E FUNDAMENTAL E SEUS LIMITES: A PESQUISA COM SERES HUMANOS E OS PARÂMETROS PROTETIVOS ESTABELECIDOS PELO DIREITO INTERNACIONAL E SUA RECEPÇÃO NO BRASIL / FREEDOM OF RESEARCH AS A HUMAN AND FUNDAMENTAL RIGHT AND I

    OpenAIRE

    Sarlet, Ingo Wolfgang; Petterle, Selma Rodrigues

    2014-01-01

    A pesquisa científica envolvendo seres humanos implica não apenas benefícios, mas também acarreta riscos para a pessoa humana, assumindo relevo o papel do Estado e da sociedade na esfera da garantia da liberdade de pesquisa, do seu fomento e desenvolvimento e da proteção dos direitos fundamentais envolvidos, tanto em nível nacional quanto internacional. Considerando isso, o presente estudo está centralizado na identificação dos principais parâmetros de proteção estabelecidos pelo direito inte...

  12. Cárceles y derechos humanos en México

    OpenAIRE

    Comisión Nacional de los Derechos Humanos

    2004-01-01

    Síntesis del informe especial de la Comisión Nacional de los Derechos Humanos sobre la situación de los derechos humanos en los centros de reclusión de la república mexicana, dependientes de gobiernos locales y municipales.

  13. DESARROLLO HUMANO: A TRAVES DE LOS OBJETIVOS FUNDAMENTALES TRANSVERSALES (OFT)

    OpenAIRE

    Mulsow G.,Gloria

    2000-01-01

    El desarrollo humano es tarea de todos y en especial del proceso de educación. Los objetivos fundamentales transversales (OFT) son un medio para desarrollar algunas actividades tendientes a favorecer el desarrollo humano de las personas, en este caso de los educandos. Operacionalizar los objetivos fundamentales en sus diferentes ámbitos es el objetivo del presente trabajo.

  14. Metastatic melanoma masquerading as a furuncle

    Directory of Open Access Journals (Sweden)

    Imran Aslam

    2017-10-01

    Full Text Available Melanoma metastasizes to the skin in about 10-17% of patients. Although there are reports of metastatic melanoma masquerading as panniculitis and erysipelas, it is very uncommon for it to present as an inflammatory skin lesion. When malignant melanoma cells invade the superficial dermal lymphatic vessels it can result in erythema, edema and induration of the overlying skin. This presentation can be problematic for clinicians if they do not suspect melanoma and choose not to biopsy the lesion. We report a case of an elderly man with a history of invasive melanoma who presented with a furuncle-like lesion that was found to be in-transit metastatic melanoma.

  15. Molecular insights into melanoma brain metastases.

    Science.gov (United States)

    Westphal, Dana; Glitza Oliva, Isabella C; Niessner, Heike

    2017-06-01

    Substantial proportions of patients with metastatic melanoma develop brain metastases during the course of their disease, often resulting in significant morbidity and death. Despite recent advances with BRAF/MEK and immune-checkpoint inhibitors in the treatment of patients who have melanoma with extracerebral metastases, patients who have melanoma brain metastases still have poor overall survival, highlighting the need for further therapy options. A deeper understanding of the molecular pathways involved in the development of melanoma brain metastases is required to develop more brain-specific therapies. Here, the authors summarize the currently known preclinical data and describe steps involved in the development of melanoma brain metastases. Only by knowing the molecular background is it possible to design new therapeutic agents that can be used to improve the outcome of patients with melanoma brain metastases. Cancer 2017;123:2163-75. © 2017 American Cancer Society. © 2017 American Cancer Society.

  16. EL PRINCIPIO DE LA JURISDICCIÓN UNIVERSAL DE LOS DERECHOS HUMANOS DESDE LA GLOBALIZACIÓN Y EL CONSTRUCTIVISMO

    Directory of Open Access Journals (Sweden)

    Walter Cadena Afanador

    2010-01-01

    Full Text Available Este trabajo analiza el contexto en el que se ha desarrollado el principio de la jurisdicción universal en derechos humanos. Dentro de su evolución como proceso sociojurídico, se encuentran algunos avances significativos. Uno de ellos es la Corte Penal Internacional, de la cual se verifica su importancia como organización internacional, en un contexto hegemónico dentro de la sociedad internacional. Dentro de las dinámicas de adaptación normativa, se requiere una lectura desde las teorías de la globalización. Para ello, se plantean reflexiones desde el constructivismo, en el marco teórico del papel de las organizaciones internacionales y la construcción de normas.

  17. Melanoma-specific marker expression in skin biopsy tissues as a tool to facilitate melanoma diagnosis.

    Science.gov (United States)

    Alexandrescu, Doru T; Kauffman, C Lisa; Jatkoe, Timothy A; Hartmann, Dan P; Vener, Tatiana; Wang, Haiying; Derecho, Carlo; Rajpurohit, Yashoda; Wang, Yixin; Palma, John F

    2010-07-01

    Diagnosis of cutaneous melanoma requires accurate differentiation of true malignant tumors from highly atypical lesions, which lack the capacity to develop uncontrolled proliferation and to metastasize. We used melanoma markers from previous work to differentiate benign and atypical lesions from melanoma using paraffin-embedded tissue. This critical step in diagnosis generates the most uncertainty and discrepancy between dermatopathologists. A total of 193 biopsy tissues were selected: 47 melanomas, 48 benign nevi, and 98 atypical/suspicious, including 48 atypical nevi and 50 melanomas as later assigned by expert dermatopathologists. Performance for SILV, GDF15, and L1CAM normalized to TYR in unequivocal melanoma versus benign nevi resulted in an area under the curve (AUC) of 0.94, 0.67, and 0.5, respectively. SILV also differentiated atypical cases classified as melanoma from atypical nevi with an AUC=0.74. Furthermore, SILV showed a significant difference between suspicious melanoma and each suspicious atypia group: melanoma versus severe atypia and melanoma versus moderate atypia had P-values of 0.0077 and 0.0009, respectively. SILV showed clear discrimination between melanoma and benign unequivocal cases as well as between different atypia subgroups in the group of suspicious samples. The role and potential utility of this molecular assay as an adjunct to the morphological diagnosis of melanoma are discussed.

  18. Melanoma of unknown origin: a case series.

    LENUS (Irish Health Repository)

    Kelly, J

    2010-12-01

    The natural history of metastatic melanoma involving lymph nodes, in the absence of a known primary site (cutaneous, ocular or mucosal) has, to date, been poorly defined; and the optimal management of this rare subtype of disease is therefore unclear. Melanomas of unknown primary site (MUP) are estimated to comprise between 3.7 and 6% of all melanomas (Anbari et al. in Cancer 79:1861-1821, 1997).

  19. Melanoma epidemiology, prognosis and trends in Latvia.

    Science.gov (United States)

    Azarjana, K; Ozola, A; Ruklisa, D; Cema, I; Rivosh, A; Azaryan, A; Pjanova, D

    2013-11-01

    Melanoma incidence and mortality rates are increasing worldwide within the white population. Clinical and histological factors have been usually used for the prognosis and assessment of the risk for melanoma. The aim of the study was to describe the clinical and histopathological features of the cutaneous melanoma (CM) in the Latvian population, to test the association between melanoma features and patient survival, and to assess the time trends for melanoma incidence. We undertook a descriptive, retrospective analysis of archive data of 984 melanoma patients treated at the largest oncological hospital of Latvia, Riga East University Hospital Latvian Oncology Centre (LOC), between 1998 and 2008. Cox proportional hazards model was used to analyse patient survival and autoregressive models were applied to detect trends in melanoma incidence over time for various categories of melanoma. The study showed a significant ascending trend in melanoma incidence in Latvia during the time period from 1998 to 2008 (ß = 1.83, 95% CI = 1.15-2.91, P = 0.011). Nodular melanoma was the most common tumour subtype with a frequency of 39.2%. Ulceration was present in 45.2% of melanomas. The mean Breslow thickness was 6.0 mm (6.8 mm) and no significant decline in median Breslow thickness was observed during the study period (P = 0.609). A better overall prognosis was detected for females in comparison with males (HR = 1.49; 95% CI = 1.22-1.81; P Latvia with the majority of melanomas diagnosed at late stages with poor prognosis for survival. © 2012 The Authors Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology.

  20. Giant hanging melanoma of the eyelid skin

    Directory of Open Access Journals (Sweden)

    Pai Radha

    2008-01-01

    Full Text Available Cutaneous melanoma of the eyelid is a rare entity. We present a 53-year-old male who had a nevus on the left upper eyelid skin since childhood, which transformed into a huge ulcerated hanging mass in the same region. Excision of the mass was done and histopathology confirmed the diagnosis of nodular malignant melanoma. A small preauricular lymph node showed metastatic melanoma on fine needle aspiration cytology.

  1. O poder e as injustiças nas pesquisas em seres humanos

    Directory of Open Access Journals (Sweden)

    William Saad Hossne

    Full Text Available Após considerações gerais sobre a ética na pesquisa envolvendo seres humanos, focaliza-se a possibilidade de ocorrências de injustiças, sob a égide de diversas formas de poder. Exemplificam-se situações concretas. Enfatiza-se a análise das possíveis injustiças à luz da Bioética, com destaque para multi e transdisciplinaridade. O autor se posiciona quanto às características atuais da Bioética, cuja ótica levou à elaboração das Diretrizes éticas para a pesquisa envolvendo seres humanos, no Brasil (Resolução 196/96 e complementares do Conselho Nacional de Saúde. Descreve-se a sistemática das atividades do Grupo Executivo de Trabalho - GET, designado pelo Conselho Nacional de Saúde (órgão de controle social na área da saúde, para elaborar as Diretrizes. É dado destaque à participação dos diversos segmentos da sociedade, evidenciando multi e transdiciplinaridade, sob a coordenação do GET, do qual o autor foi Presidente. Comentam-se os principais tópicos das Diretrizes brasileiras, enfocando-se a sua relação com o tema de poder e injustiça. Salienta-se o papel dos Comitês de Ética em Pesquisa - CEP e da Comissão Nacional de Ética em Pesquisa - CONEP.

  2. About human genome Acerca del genoma humano

    Directory of Open Access Journals (Sweden)

    Mojica Tobias

    2000-12-01

    Full Text Available The sequence ofthe human genome, an undertaking ofadvanced countries, is nearly complete. In fact The Human Genome Project has around 85% ofthe genome sequenced 4 times on the average, with an accuracy of roughly 1 in 1000 nucleotides. Celera Genomics, on the other hand, has 99% of the sequence of one person, with an accuracy of slightly less than 1 in 100. The Human Genome project trives to produce a physical map for public consumption following a step by step strategy, in which the researcher sequences short DNA fragments belonging to Iarger fragments of known relative
    position. Celera Genomics wants to have very rapidly a physical map which can be quickly used to develop genetic tests and drugs, which can be later sold. We feel that the sequence ofthe human genome is something, which will widen the gap between advanced and backward countries.En este artículo se revisan los eventos, alrededor del secuenciamiento del genoma humano, que han llevado a tanta excitación en los medios noticiosos y académicos en meses recientes. Se explican las estrategias que han llevado a que tengamos dos borradores diferentes pero complementarios, la estrategia llevada a cabo con el dinero
    de los contribuyentes que consiste en establecer el orden de fragmentos grandes de DNA antes de ser secuenciados y la estrategia llevada a cabo con dineros aportados por la industria privada, con la intención de explotar gananciosamente el conocimiento derivado del genoma humano. El genoma humano a mediados del año 2000 es
    un borrador incompleto que cubre aliededor del 85% de la secuencia con una precisión de un error en 1000 y el 99% de la secuencia con una precisión menor de 1 en 100 nucleótidos, También se discuten algunas de las posibles avenidas

  3. Una propuesta alternativa a la concepción del llamado capital humano = Incorporation of sociological and axiological elements to the process of individuals' formation

    Directory of Open Access Journals (Sweden)

    Guitart, Silvia Odriozola

    2013-01-01

    Full Text Available La teoría del capital humano, pese a su gran aceptación universal, ha sido criticada desde diversas perspectivas. Sin embargo, en no pocas ocasiones se asimila con insuficientes reflexiones sobre su significación más profunda. No se trata de criticar el término capital humano; tampoco de redefinirlo. Se trata de romper con la lógica de pensamiento de la teoría que lo sustenta (la lógica de pensamiento de la teoría neoclásica y formular una nueva concepción que englobe las nociones acerca de la formación de los individuos y su importancia para el progreso de la sociedad, desde el desarrollo libre, universal y emancipador de los seres humanos. En este sentido, una sociedad no excluyente y emancipadora no puede limitar el papel del ser humano a su función en el proceso productivo, sino que debe considerar su participación activa y consciente en la transformación de la realidad, en aras de su desarrollo pleno y universal. Esto último condiciona la necesidad de avanzar en propuestas alternativas que superen la estrechez de las consideraciones meramente económicas que sustentan la teoría del capital humano, a partir de la incorporación de elementos sociológicos y axiológicos al proceso de formación de los individuos

  4. Timely Healthcare Checkup Catches Melanoma Early

    Science.gov (United States)

    ... Skin Cancer" Articles Skin Cancer Can Strike Anyone / Skin Cancer: Biology, Risk Factors & Treatment / Timely Healthcare Checkup Catches Melanoma Early / NIH Research to Results / Skin and Sun – ...

  5. Genomic characterisation of acral melanoma cell lines.

    Science.gov (United States)

    Furney, Simon J; Turajlic, Samra; Fenwick, Kerry; Lambros, Maryou B; MacKay, Alan; Ricken, Gerda; Mitsopoulos, Costas; Kozarewa, Iwanka; Hakas, Jarle; Zvelebil, Marketa; Lord, Christopher J; Ashworth, Alan; Reis-Filho, Jorge S; Herlyn, Meenhard; Murata, Hiroshi; Marais, Richard

    2012-07-01

    Acral melanoma is a rare melanoma subtype with distinct epidemiological, clinical and genetic features. To determine if acral melanoma cell lines are representative of this melanoma subtype, six lines were analysed by whole-exome sequencing and array comparative genomic hybridisation. We demonstrate that the cell lines display a mutation rate that is comparable to that of published primary and metastatic acral melanomas and observe a mutational signature suggestive of UV-induced mutagenesis in two of the cell lines. Mutations were identified in oncogenes and tumour suppressors previously linked to melanoma including BRAF, NRAS, KIT, PTEN and TP53, in cancer genes not previously linked to melanoma and in genes linked to DNA repair such as BRCA1 and BRCA2. Our findings provide strong circumstantial evidence to suggest that acral melanoma cell lines and acral tumours share genetic features in common and that these cells are therefore valuable tools to investigate the biology of this aggressive melanoma subtype. Data are available at: http://rock.icr.ac.uk/collaborations/Furney_et_al_2012/. © 2012 John Wiley & Sons A/S.

  6. Melanoma of the skin in the Danish Cancer Registry and the Danish Melanoma Database: A Validation Study.

    Science.gov (United States)

    Pedersen, Sidsel Arnspang; Schmidt, Sigrun Alba Johannesdottir; Klausen, Siri; Pottegård, Anton; Friis, Søren; Hölmich, Lisbet Rosenkrantz; Gaist, David

    2018-01-15

    The nationwide Danish Cancer Registry and the Danish Melanoma Database both record data on melanoma for purposes of monitoring, quality assurance and research. However, the data quality of the Cancer Registry and the Melanoma Database has not been formally evaluated. We estimated the positive predictive value (PPV) of melanoma diagnosis for random samples of 200 patients from the Cancer Registry (n=200) and the Melanoma Database (n=200) during 2004-2014, using the Danish Pathology Registry as 'gold-standard' reference. We further validated tumor characteristics in the Cancer Registry and the Melanoma Database. Additionally, we estimated the PPV of in situ melanoma diagnoses in the Melanoma Database, and the sensitivity of melanoma diagnoses in 2004-2014. The PPVs of melanoma in the Cancer Registry and the Melanoma Database were 97% (95% CI, 94-99) and 100%. The sensitivity was 90% in the Cancer Registry and 77% in the Melanoma Database. The PPV of in situ melanomas in the Melanoma Database was 97% and the sensitivity was 56%. In the Melanoma Database, we observed PPVs of ulceration of 75% and Breslow thickness of 96%. The PPV of histologic subtypes varied between 87%-100% in the Cancer Registry and 93%-100% in the Melanoma Database. The PPVs for anatomical localization were 83%-95.0% in the Cancer Registry and 93%-100% in the Melanoma Database. The data quality in both the Cancer Registry and the Melanoma Database are high, supporting their use in epidemiologic studies.

  7. UVB: suscetibilidade no melanoma maligno

    OpenAIRE

    Nasser,Nilton

    2010-01-01

    FUNDAMENTOS: Está bem definido que a radiação ultravioleta provoca depleção imunológica na pele, permitindo o desenvolvimento de tumores cutâneos malignos. A maioria dos pacientes de cânceres da pele não melanomas são considerados UVB-suscetíveis. OBJETIVOS: Estudar a UVB-suscetibilidade nos pacientes com melanoma maligno e se este é um fator de risco para o desenvolvimento desse câncer. MÉTODOS: Foram selecionados 88 voluntários divididos em dois grupos: grupo-controle saudável (n=61) e grup...

  8. [Acute dyspnea in malignant melanoma].

    Science.gov (United States)

    Franzen, A M; Günzel, T

    2011-09-01

    Metastases to the larynx are rare. The current article presents the case of a 75-year-old patient with a history of shortness of breath due to a supraglottic exophytic lesion that was identified as a metastasis of a cutaneous melanoma treated 2.5 years previously. As a result of our medline analysis we found approximately 30 cases of metastatic melanoma to the larynx published to date. Primary tumors are always cutaneous in origin and spread over the whole integument of trunk and extremities. The time interval between diagnosis of the primary and the laryngeal metastasis is often several years. In most reports a supraglottic exophytic, red coloured lesion is described. Diagnosis can only be proven by histological examination. Laryngeal metastasis is usually an indication of tumor dissemination and always has a fatal prognosis.

  9. Neutron capture therapy for melanoma

    International Nuclear Information System (INIS)

    Coderre, J.A.; Glass, J.D.; Micca, P.; Fairchild, R.G.

    1988-01-01

    The development of boron-containing compounds which localize selectively in tumor may require a tumor-by-tumor type of approach that exploits any metabolic pathways unique to the particular type of tumor. Melanin-producing melanomas actively transport and metabolize aromatic amino acids for use as precursors in the synthesis of the pigment melanin. It has been shown that the boron-containing amino acid analog p-borono-phenylalanine (BPA) is selectively accumulated in melanoma tissue, producing boron concentrations in tumor that are within the range estimated to be necessary for successful boron neutron capture therapy (BNCT). We report here the results of therapy experiments carried out at the Brookhaven Medical Research Reactor (BMRR). 21 refs., 5 figs., 3 tabs

  10. BRAF mutations in conjunctival melanoma

    DEFF Research Database (Denmark)

    Larsen, Ann-Cathrine; Dahl, Christina; Dahmcke, Christina M.

    2016-01-01

    with atypia. BRAF mutations were identified in 39 of 111 (35%) cases. The rate ratio of BRAF-mutated versus BRAF-wild-type melanoma did not change over time. BRAF mutations were associated with T1 stage (p = 0.007), young age (p = 0.001), male gender (p = 0.02), sun-exposed location (p = 0.01), mixed....../non-pigmented tumour colour (p = 0.02) and nevus origin (p = 0.005), but did not associate with prognosis. BRAF status in conjunctival melanoma and paired premalignant lesions corresponded in 19 of 20 cases. Immunohistochemistry detected BRAF V600E mutations with a sensitivity of 0.94 and a specificity of 1...

  11. Neutron capture therapy for melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Coderre, J.A.; Glass, J.D.; Micca, P.; Fairchild, R.G.

    1988-01-01

    The development of boron-containing compounds which localize selectively in tumor may require a tumor-by-tumor type of approach that exploits any metabolic pathways unique to the particular type of tumor. Melanin-producing melanomas actively transport and metabolize aromatic amino acids for use as precursors in the synthesis of the pigment melanin. It has been shown that the boron-containing amino acid analog p-borono-phenylalanine (BPA) is selectively accumulated in melanoma tissue, producing boron concentrations in tumor that are within the range estimated to be necessary for successful boron neutron capture therapy (BNCT). We report here the results of therapy experiments carried out at the Brookhaven Medical Research Reactor (BMRR). 21 refs., 5 figs., 3 tabs.

  12. Direitos humanos e OEA. Processos e procedimentos

    Directory of Open Access Journals (Sweden)

    Christian Perrone

    2015-08-01

    Full Text Available Este artigo busca preencher a lacuna no tratamento do Direito Internacional dos Direitos Humanos, focando nos procedimentos internos dos organismos internacionais que acabam por dar corpo (positiva ou negativamente para estes conceitos jurídicos. Os três principais eixos serão os órgãos da Organização dos Estados Americanos que tratam destes direitos, os procedimentos gerais, e os mecanismos individuais de proteção. Como conclusão, tem-se que toda a Organização é responsável pela realização, desenvolvimento e proteção de direitos e que a sociedade coletiva ou individualmente possui espaço de influência através de mecanismos próprios.

  13. Complejidad del dolor y el sufrimiento humano

    Directory of Open Access Journals (Sweden)

    Carlos Rojas Malpica

    Full Text Available En el presente trabajo se discute una cierta concepción unidireccional que, desde el positivismo lógico, se ha venido imponiendo en la investigación médico-psiquiátrica. Aunque la mayoría de los enfermos y de los investigadores insistan en presentar y/o estudiar el dolor y el sufrimiento humano a partir de sus características más molestas y desagradables, estos son fenómenos complejos que no admiten esa sola lectura. Un recorrido por la filosofía, la fenomenología y el psicoanálisis nos aproximará a posibilidades poco exploradas por la medicina, para comprender mejor la complejidad del problema más allá de los síntomas y de la neurofisiología.

  14. Direitos Humanos em Kant e Habermas

    Directory of Open Access Journals (Sweden)

    Alessandro Pinzani

    2011-12-01

    Full Text Available http://dx.doi.org/10.5007/1677-2954.2011v10n1p179 O livro de Milene Tonetto é mais ambicioso do que o título poderia deixar pensar. Longe de limitar-se a uma exposição da temática dos direitos humanos nos dois autores em questão, o texto representa uma contribuição importante à discussão acerca dos fundamentos do direito em Kant e da relação entre direito e moral na obra deste pensador, assim como à discussão acerca da fundamentação do direito oferecida por Habermas.

  15. Thigmotropism of Malignant Melanoma Cells

    OpenAIRE

    Quatresooz, Pascale; Pi?rard-Franchimont, Claudine; No?l, Fanchon; Pi?rard, G?rald E.

    2011-01-01

    During malignant melanoma (MM) progression including incipient metastasis, neoplastic cells follow some specific migration paths inside the skin. In particular, they progress along the dermoepidermal basement membrane, the hair follicles, the sweat gland apparatus, nerves, and the near perivascular space. These features evoke the thigmotropism phenomenon defined as a contact-sensing growth of cells. This process is likely connected to modulation in cell tensegrity (control of the cell shape)....

  16. Dermoscopic evaluation of nodular melanoma.

    Science.gov (United States)

    Menzies, Scott W; Moloney, Fergal J; Byth, Karen; Avramidis, Michelle; Argenziano, Giuseppe; Zalaudek, Iris; Braun, Ralph P; Malvehy, Josep; Puig, Susana; Rabinovitz, Harold S; Oliviero, Margaret; Cabo, Horacio; Bono, Riccardo; Pizzichetta, Maria A; Claeson, Magdalena; Gaffney, Daniel C; Soyer, H Peter; Stanganelli, Ignazio; Scolyer, Richard A; Guitera, Pascale; Kelly, John; McCurdy, Olivia; Llambrich, Alex; Marghoob, Ashfaq A; Zaballos, Pedro; Kirchesch, Herbert M; Piccolo, Domenico; Bowling, Jonathan; Thomas, Luc; Terstappen, Karin; Tanaka, Masaru; Pellacani, Giovanni; Pagnanelli, Gianluca; Ghigliotti, Giovanni; Ortega, Blanca Carlos; Crafter, Greg; Ortiz, Ana María Perusquía; Tromme, Isabelle; Karaarslan, Isil Kilinc; Ozdemir, Fezal; Tam, Anthony; Landi, Christian; Norton, Peter; Kaçar, Nida; Rudnicka, Lidia; Slowinska, Monika; Simionescu, Olga; Di Stefani, Alessandro; Coates, Elliot; Kreusch, Juergen

    2013-06-01

    Nodular melanoma (NM) is a rapidly progressing potentially lethal skin tumor for which early diagnosis is critical. To determine the dermoscopy features of NM. Eighty-three cases of NM, 134 of invasive non-NM, 115 of nodular benign melanocytic tumors, and 135 of nodular nonmelanocytic tumors were scored for dermoscopy features using modified and previously described methods. Lesions were separated into amelanotic/hypomelanotic or pigmented to assess outcomes. Predominantly hospital-based clinics from 5 continents. Sensitivity, specificity, and odds ratios for features/models for the diagnosis of melanoma. Nodular melanoma occurred more frequently as amelanotic/hypomelanotic (37.3%) than did invasive non-NM (7.5%). Pigmented NM had a more frequent (compared with invasive non-NM; in descending order of odds ratio) symmetrical pigmentation pattern (5.8% vs 0.8%), large-diameter vessels, areas of homogeneous blue pigmentation, symmetrical shape, predominant peripheral vessels, blue-white veil, pink color, black color, and milky red/pink areas. Pigmented NM less frequently displayed an atypical broadened network, pigment network or pseudonetwork, multiple blue-gray dots, scarlike depigmentation, irregularly distributed and sized brown dots and globules, tan color, irregularly shaped depigmentation, and irregularly distributed and sized dots and globules of any color. The most important positive correlating features of pigmented NM vs nodular nonmelanoma were peripheral black dots/globules, multiple brown dots, irregular black dots/globules, blue-white veil, homogeneous blue pigmentation, 5 to 6 colors, and black color. A model to classify a lesion as melanocytic gave a high sensitivity (>98.0%) for both nodular pigmented and nonnodular pigmented melanoma but a lower sensitivity for amelanotic/hypomelanotic NM (84%). A method for diagnosing amelanotic/hypomelanotic malignant lesions (including basal cell carcinoma) gave a 93% sensitivity and 70% specificity for NM. When

  17. Antimicrobial effect of human serum on oral Fusobacterium nucleatum isolates from humans and monkeys Atividade antimicrobiana do soro humano sobre isolados de Fusobacterium nucleatum obtidos de humanos e macacos

    Directory of Open Access Journals (Sweden)

    Elerson GAETTI-JARDIM JÚNIOR

    1999-01-01

    Full Text Available The susceptibility of eighty F. nucleatum isolates from periodontal patients, healthy subjects and Cebus apella monkeys to human pooled sera was tested. The resistance to serum bactericidal effects was observed in 46.9% of the isolates from periodontal patients, 28.6% of the healthy subjects and 40% of the monkeys. These results support the hypothesis that serum plays an ecological role by controlling the microbial population inside either the gingival crevice or periodontal pocket.Foi avaliada a susceptibilidade de oitenta isolados de F. nucleatum obtidos de pacientes com doença periodontal, indivíduos sadios e Cebus apella (macaco-prego frente ao soro humano. A resistência à atividade bactericida do soro foi observada em 46,9% das fusobactérias isoladas de pacientes com doença periodontal, 28,6% das obtidas de indivíduos sadios e em 40% das fusobactérias de primatas não humanos. Esses resultados suportam o conceito de que o soro possui um papel ecológico em controlar a população microbiana no interior do sulco gengival ou bolsa periodontal.

  18. El sentido humano entre enfermera y paciente

    Directory of Open Access Journals (Sweden)

    Erika Nathalia Rojas-Moreno

    2006-12-01

    Full Text Available Este ensayo retoma la Enfermería como una profesión de gran importancia a nivel mundial, no solo por la preparación técnica, científica e investigativa que la caracteriza, sino por aquel sentido humano que la identifica y a la vez la diferencia de todas las demos carreras formativas en el área de la salud. Sin embargo, en la actualidad surge una enorme preocupación debido a que en el ejercicio de la labor, los enfermeros (as se han olvidado que los pacientes, más que instrumentos de trabajo son seres humanos que necesitan de un amigo cercano para superar la enfermedad que afecta su cuerpo y a la vez entristece su espíritu. Por esta razón se retoma la teoría de la Enfermería Psicodinornica de Hildegard E. Peplau a fin de recordar los seis roles frol de extrana, rol de suministradora de recursos, rol de educadora, rol de !icier, rol de sustituta y rol de consejera y las cuatro fases (Orientación, identificación, exploración y resolución], que de manera sencilla y concreta, enmarcan nuestra significativa labor en la relación enfermera-paciente. El ensayo finaliza presentando un breve análisis de lo que una relación de ayuda puede hacer en beneficio de la vida del paciente y del profesional de enfermería puesto que a lo largo del tiempo se ha demostrado que esta, contribuye en gran medida al crecimiento personal del individuo.

  19. UVB: suscetibilidade no melanoma maligno UVB: susceptibility in malignant melanoma

    Directory of Open Access Journals (Sweden)

    Nilton Nasser

    2010-12-01

    Full Text Available FUNDAMENTOS: Está bem definido que a radiação ultravioleta provoca depleção imunológica na pele, permitindo o desenvolvimento de tumores cutâneos malignos. A maioria dos pacientes de cânceres da pele não melanomas são considerados UVB-suscetíveis. OBJETIVOS: Estudar a UVB-suscetibilidade nos pacientes com melanoma maligno e se este é um fator de risco para o desenvolvimento desse câncer. MÉTODOS: Foram selecionados 88 voluntários divididos em dois grupos: grupo-controle saudável (n=61 e grupo de portadores de melanoma (n=27, todos identificados de acordo com os critérios: tipo histológico, nível de invasão, fotótipos de pele, sexo e idade. A suscetibilidade à radiação ultravioleta B (UVB foi medida pela reação de hipersensibilidade ao contato com o difenciprone nos voluntários sensibilizados em áreas previamente irradiadas. RESULTADOS: A suscetibilidade à radiação UVB foi de 81,5% nos pacientes com melanoma maligno e de 31,2% no grupo-controle. O risco de um indivíduo desenvolver o melanoma maligno foi 9,7 vezes maior do que nos indivíduos UVB-resistentes. CONCLUSÕES: A UVB-suscetibilidade pode ser considerada um fator de risco importante para o desenvolvimento do melanoma maligno.BACKGROUND: It is well established that UV radiation provokes an immunological depletion in the skin, enabling the development of malignant cutaneous tumors. Most nonmelanoma skin cancer patients are considered to be UVB-susceptible. OBJECTIVE: To study the behavior of UVB- susceptibility in malignant melanoma (MM patients and whether this is a risk factor to the development of MM. METHODS: Eighty-eight volunteers were selected and divided into two groups: healthy control group (n = 61 and MM group (n = 27, which were identified according to the following clinical criteria: histopathological type, level of invasion, skin phototype, sex and age. Susceptibility to ultraviolet B (UVB radiation was measured by the onset of a contact

  20. Spontaneous Splenic Rupture in Melanoma

    Directory of Open Access Journals (Sweden)

    Hadi Mirfazaelian

    2014-01-01

    Full Text Available Spontaneous rupture of spleen due to malignant melanoma is a rare situation, with only a few case reports in the literature. This study reports a previously healthy, 30-year-old man who came with chief complaint of acute abdominal pain to emergency room. On physical examination, abdominal tenderness and guarding were detected to be coincident with hypotension. Ultrasonography revealed mild splenomegaly with moderate free fluid in abdominopelvic cavity. Considering acute abdominal pain and hemodynamic instability, he underwent splenectomy with splenic rupture as the source of bleeding. Histologic examination showed diffuse infiltration by tumor. Immunohistochemical study (positive for S100, HMB45, and vimentin and negative for CK, CD10, CK20, CK7, CD30, LCA, EMA, and chromogranin confirmed metastatic malignant melanoma. On further questioning, there was a past history of a nasal dark skin lesion which was removed two years ago with no pathologic examination. Spontaneous (nontraumatic rupture of spleen is an uncommon situation and it happens very rarely due to neoplastic metastasis. Metastasis of malignant melanoma is one of the rare causes of the spontaneous rupture of spleen.

  1. Do melanoma patients with melanoma of unknown primary have better survival than patients with melanoma of known primary?

    DEFF Research Database (Denmark)

    Rødgaard, Jes Christian; Kjerkegaard, Ulrik; Sørensen, Jens Ahm

    2018-01-01

    Background: Several studies have compared the survival rate of melanoma of unknown primary (MUP) patients with patients with a known primary melanoma (MKP). Some studies found improved survival in MUP patients, whereas others found similar or poorer outcomes. The aim of this study was to evaluate...

  2. Is the prognosis and course of acral melanoma related to site-specific clinicopathological features?

    NARCIS (Netherlands)

    Paolino, G.; Bekkenk, M. W.; Didona, D.; Eibenschutz, L.; Richetta, A. G.; Cantisani, C.; Viti, G.; Carbone, A.; Buccini, P.; de Simone, P.; Ferrari, A.; Scali, E.; Calvieri, S.; Silipo, V.; Cigna, E.; Viti, G. P.; Bottoni, U.

    2016-01-01

    Acral melanoma is an uncommon type of melanoma in Caucasian patients. However, acral melanoma is the most common type of melanoma in African and Asian patients. Comparison analyses between hand-acral melanoma and foot-acral melanoma have been rarely reported in the literature. Acral melanoma is an

  3. Nodular melanoma: a distinct clinical entity and the largest contributor to melanoma deaths in Victoria, Australia.

    Science.gov (United States)

    Mar, Victoria; Roberts, Hugh; Wolfe, Rory; English, Dallas R; Kelly, John W

    2013-04-01

    There is a growing body of evidence that nodular melanoma (NM), because of its association with increased growth rate and thickness at diagnosis, accounts for a substantial proportion of melanoma deaths. We sought to assess the contribution of NM to melanoma deaths in comparison with other tumor subtypes. Four cohorts were established comprising 5775 cases of invasive primary cutaneous melanoma reported to the Victorian Cancer Registry during 1989, 1994, 1999, and 2004. Original pathology reports were reviewed. Age-standardized melanoma incidence rates were compared from 1989 to 2004 with annual percentage change using Poisson regression. The incidence of thick tumors (>4 mm) increased by 3.8% (95% confidence interval 1.4 to 6.2) and 2.5% (95% confidence interval -0.5 to 5.5) per year for male and female patients, respectively. The median thickness of NM at diagnosis was 2.6 mm compared with 0.6 mm for superficial spreading melanoma. A third of patients who died from melanoma during the follow-up period had thick tumors (>4 mm), most of which were nodular subtype (61%). NM accounted for 14% of invasive melanomas, but was responsible for 43% of melanoma deaths in a total of 57,461 person-years of follow-up. By comparison, superficial spreading melanoma contributed 56% of invasive melanoma but only 30% of deaths. Pathology review was limited to reports only. Mortality information relied mostly on death certificate information. The incidence of thick melanomas continues to increase. Nodular melanoma is clinically distinct and the predominant contributor to melanoma-related deaths, representing a public health challenge in reducing skin cancer mortality. Copyright © 2012 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  4. Nodular melanoma is less likely than superficial spreading melanoma to be histologically associated with a naevus.

    Science.gov (United States)

    Pan, Yan; Adler, Nikki R; Wolfe, Rory; McLean, Catriona A; Kelly, John W

    2017-10-16

    To determine the frequency of naevus-associated melanoma among superficial spreading and nodular subtypes; and to investigate associations between naevus-associated melanoma and other clinico-pathological characteristics. Cross-sectional study of all patients with nodular and superficial spreading melanomas diagnosed between 1994 and 2015 at the Victorian Melanoma Service, Melbourne. Clinical and pathological characteristics of naevus-associated and de novo melanomas were assessed in univariable and multivariable logistic regression analyses. Of 3678 primary melanomas, 1360 (37.0%) were histologically associated with a naevus and 2318 (63.0%) were de novo melanomas; 71 of 621 nodular (11.4%) and 1289 of 3057 superficial spreading melanomas (42.2%) were histologically associated with a naevus. In multivariable analyses, the odds of being associated with a naevus were higher for melanomas located on the trunk (v head and neck: adjusted odds ratio [OR], 2.27; 95% CI, 1.73-2.96; P melanomas (adjusted OR, 0.68; 95% CI, 0.48-0.97; P = 0.035), and older age (patients 70 years or older v patients under 30 at diagnosis: adjusted OR, 0.28; 95% CI, 0.20-0.40; P melanomas as for nodular melanomas (adjusted OR, 3.05; 95% CI, 2.24-4.17; P Melanomas are most likely to arise in the absence of a pre-existing naevus, particularly nodular melanomas. Public health campaigns should therefore emphasise the detection of suspicious de novo lesions, as well as of changing lesions.

  5. Os Direitos Humanos e o Direito Internacional do Meio Ambiente

    OpenAIRE

    Vitória Schmidt, Rafael

    2010-01-01

    Este artigo objetiva analisar, no que se refere ao direito internacional, em que medida a proteção ao meio ambiente se insere na relação dos direitos humanos fundamentais. Até o marco estabelecido pela declaração de Estocolmo de 1972, o meio ambiente era considerado, no plano global, uma questão alienada da humanidade e dos direitos humanos. Atualmente, o já denominado Direito Internacional do Meio Ambiente, ao lado da proteção internacional dos Direitos Humanos, constitui um dos temas princi...

  6. Genoma humano. Actualidades y perspectivas bioéticas. (Ensayo I Human genome: Bioethical novelties and perspectives (Essay I

    Directory of Open Access Journals (Sweden)

    Diana Martín Ross

    2002-04-01

    Full Text Available Una de las investigaciones más fabulosas, sorprendentes y gigantes, comparada por muchos con el Proyecto Apolo o el Proyecto Manhattan, es el Proyecto Genoma Humano (PGH mediante el cual se intenta ubicar y conocer el papel de los genes que constituyen al ser humano. De manera que los genes y el genoma, de forma particular y la Genética en general se han convertido en el “terremoto de la ciencia contemporánea” por ello hemos decidido incursionar en el empeño de conocer mas de cerca lo intrincado y misterioso del “Poder de los Genes” y los dilemas bioéticos que promueven las actuales investigaciones y la aplicación de sus resultados. En esta primera parte de este ensayo exponemos de forma precisa aspectos relacionados con la historia y actualidad del Proyecto Genoma Humano y la Terapia Génica, así como los beneficios y riesgos potenciales que implican, tanto para los países desarrollados como para los países del SurOne of the most fabulous, surprising and enormous investigations, compared by many with the Apollo Project or the Manhattan Project, is the Human Genome Project (HGP by means of which it is intended to locate and to know the role of human genes. In this way, genes and genome, particularly and Genetics in general have become the "earthquake of contemporary science". That's why, we have decided to deepen into people's endeavour of knowing closely the entangled and mysterious world of “Genes' Power", as well as the bioethical dilemmas that the current investigations and the application of their results promote. In this first part of this essay we expose clearly aspects related to the history and novelties of the Human Genome Project and Genic Therapy, and also the benefits and potential risks that they imply, for developed and underdeveloped countries

  7. Isolated Pancreatic Metastasis from Malignant Melanoma: Is ...

    African Journals Online (AJOL)

    Isolated pancreatic metastasis from malignant melanoma (IPMMM) is rare because most melanoma patients already have a widespread disease at diagnosis. No adjuvant systemic treatment is known to be effi cient in this setting. Experience with pancreatic resection for IPMMM is limited and controversial. We report here ...

  8. Primary malignant melanoma of the nasal cavity.

    Science.gov (United States)

    Uysal, Ismail Önder; Misir, Mustafa; Polat, Kerem; Altuntaş, Emine Elif; Atalar, Mehmet Haydar; Tuncer, Ersin; Müderris, Suphi

    2012-01-01

    Primary malignant melanoma of the nose and paranasal sinus mucosa is a rare disease and seen in less than 1% among all melanomas. Malignant melanomas have 2 origins: cutaneous and mucosal. The mucosal form has a worse prognosis because of its aggressiveness compared with that of the cutaneous form. Mucosal melanomas often occur at a rate of 2% to 3% among all melanomas and are typically found in the nasal cavity and paranasal sinuses. Generally, it is more common in males and in those older than 50 years. In this study, 4 patients were observed at the Cumhuriyet University Faculty of Medicine; 2 of them were a 64-year-old man and an 82-year-old woman who had a malignant melanoma originating from the nasal septal mucosa, 1 patient was a 72-year-old woman whose malignant melanoma originated from the inferior turbinate, and 1 patient was a 77-year-old woman with a sinonasally located melanoma. The conditions of these patients were discussed under the light of literature instructions.

  9. PRIMARY MALIGNANT MELANOMA OF ARYEPIGLOTTIC FOLD

    African Journals Online (AJOL)

    2015-12-01

    Dec 1, 2015 ... ing including positron emission tomography (PET) scan failed to reveal a primary source of malignant melanoma. So, the patient was diagnosed as primary malignant melanoma of aryepiglottic mucosa. Figure 1 Photomicrograph showing origin of melano- ma (H&E, 100x). Figure 2 Photomicrograph ...

  10. Malignant melanoma at a scientific laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Shy, C.M.; Checkoway, H.; Marshall, E.G.

    1985-11-15

    The general consensus of the seven reviewers is that occupational exposures at Lawrence Livermore National Laboratory have not been established as a causal factor for the observed excess of malignant melanoma. Several observations support the impression that some or all of the observed melanoma excess may be attributable to intense surveillance and enhanced detection of early stage melanoma lesions. Since the incidence of melanomas among Laboratory employees has not diminished, an early harvesting effect is unlikely. This suggests the distinct possibility that localized, in situ melanomas that would normally not be detected are being reported, and that in the absence of this enhanced detection, many of these early stage lesions would show little or no clinical progression. This phenomenon would explain the continued high incidence of melanomas in the absence of a physical or chemical inciting cause. A key point in this reasoning is the issue of the rate of growth of early stage melanomas, and this point remains a key question for study. Even if the observed excess cannot be explained by detection bias, the reviewers agree that the Austin and Reynolds' study does not make a convincing case for occupational factors being a cause of the high melanoma incidence. 6 refs.

  11. Histopathological study of malignant melanoma in highlanders ...

    African Journals Online (AJOL)

    Histopathological study of malignant melanoma in highlanders. AZ Mohammed, AN Manasseh, BM Mandong, ST Edino. Abstract. Background:Malignant melanoma is a fatal skin cancer that is curable when detected and treated early. Recent reports indicate a rising incidence globally. This study aims at identifying the ...

  12. Intraoral malignant melanoma | Babburi | Nigerian Medical Journal

    African Journals Online (AJOL)

    Primary oral mucosal melanoma is a rare aggressive neoplasm and accounts for only 0.2‑8% of all reported melanomas. It is a malignant neoplasm of melanocytes that may arise from a benign melanocytic lesion or de novo from melanocytes within normal skin or mucosa. It is considered to be the most deadly and ...

  13. Towards new therapeutic approaches for malignant melanoma.

    Science.gov (United States)

    Pacheco, Ivan; Buzea, Cristina; Tron, Victor

    2011-11-01

    Recent progress in understanding the molecular mechanisms of the initiation and progression of melanoma has created new opportunities for developing novel therapeutic modalities to manage this potentially lethal disease. Although at first glance, melanoma carcinogenesis appears to be a chaotic system, it is indeed, arguably, a deterministic multistep process involving sequential alterations of proto-oncogenes, tumour suppressors and miRNA genes. The scope of this article is to discuss the most recent and significant advances in melanoma molecular therapeutics. It is apparent that using single agents targeting solely individual melanoma pathways might be insufficient for long-term survival. However, the outstanding results on melanoma survival observed with novel selective inhibitors of B-RAF, such as PLX4032 give hope that melanoma can be cured. The fact that melanoma develops acquired resistance to PLX4032 emphasises the importance of simultaneously targeting several pathways. Because the most striking feature of melanoma is its unsurpassed ability to metastasise, it is important to implement newer systems for drug delivery adapted from research on stem cells and nanotechnology.

  14. Checkpoint Inhibitors Hold Promise for Rare Melanoma

    Science.gov (United States)

    Patients with a rare form of melanoma, called desmoplastic melanoma, may be particularly likely to benefit from immune checkpoint inhibitors, a new study shows. As this Cancer Currents post explains, an NCI-sponsored clinical trial is already testing one such drug, pembrolizumab (Keytruda) in patients with this cancer.

  15. Mistletoe in the treatment of malignant melanoma

    Directory of Open Access Journals (Sweden)

    Esin Sakallı Çetin

    2014-03-01

    Full Text Available Malignant melanoma is a malignant neoplasia drives from melanocytes. Malignant melanoma, the most causing death, is seen in the third place at skin cancer. Malignant melanoma shows intrinsic resistance to chemotherapeutic agents and variability in the course of the disease which are distinct features separating from other solid tumors. These features prevent the development and standardization of non-surgical treatment models of malignant melanoma. Although there is a large number of chemotherapeutic agents used in the treatment of metastatic malignant melanoma, it hasn’t been demonstrated the survival advantage of adjuvant treatment with chemotherapeutic agents. Because of the different clinical course of malignant melanoma, the disease is thought to be closely associated with immune system. Therefore, immunomodulatory therapy models were developed. Mistletoe stimulates the immune system by increasing the number and activity of dendritic cells, thus it has been shown to effect on tumor growth and metastasis of malignant melanoma patient. Outlined in this review are the recent developments in the understanding the role of mistletoe as a complementary therapy for malignant melanoma. J Clin Exp Invest 2014; 5 (1: 145-152

  16. Primary malignant melanoma of aryepiglottic fold | Chhabra | Ghana ...

    African Journals Online (AJOL)

    Background: Primary malignant melanoma rarely arises from noncutaneous tissues that contain melanocytes. Head and neck mucosal melanomas account for 0.7% to 3.8% of all melanomas. Here we report a case of primary malignant melanoma of aryepiglottic fold. Result: Here we reported a case of primary malignant ...

  17. Progression of cutaneous melanoma: implications for treatment

    Science.gov (United States)

    Leong, Stanley P. L.; Mihm, Martin C.; Murphy, George F.; Hoon, Dave S. B.; Kashani-Sabet, Mohammed; Agarwala, Sanjiv S.; Zager, Jonathan S.; Hauschild, Axel; Sondak, Vernon K.; Guild, Valerie; Kirkwood, John M.

    2015-01-01

    The survival rates of melanoma, like any type of cancer, become worse with advancing stage. Spectrum theory is most consistent with the progression of melanoma from the primary site to the in-transit locations, regional or sentinel lymph nodes and beyond to the distant sites. Therefore, early diagnosis and surgical treatment before its spread is the most effective treatment. Recently, new approaches have revolutionized the diagnosis and treatment of melanoma. Genomic profiling and sequencing will form the basis for molecular taxonomy for more accurate subgrouping of melanoma patients in the future. New insights of molecular mechanisms of metastasis are summarized in this review article. Sentinel lymph node biopsy has become a standard of care for staging primary melanoma without the need for a more morbid complete regional lymph node dissection. With recent developments in molecular biology and genomics, novel molecular targeted therapy is being developed through clinical trials. PMID:22892755

  18. From Melanocyte to Metastatic Malignant Melanoma

    Directory of Open Access Journals (Sweden)

    Bizhan Bandarchi

    2010-01-01

    Full Text Available Malignant melanoma is one of the most aggressive malignancies in human and is responsible for almost 60% of lethal skin tumors. Its incidence has been increasing in white population in the past two decades. There is a complex interaction of environmental (exogenous and endogenous, including genetic, risk factors in developing malignant melanoma. 8–12% of familial melanomas occur in a familial setting related to mutation of the CDKN2A gene that encodes p16. The aim of this is to briefly review the microanatomy and physiology of the melanocytes, epidemiology, risk factors, clinical presentation, historical classification and histopathology and, more in details, the most recent discoveries in biology and genetics of malignant melanoma. At the end, the final version of 2009 AJCC malignant melanoma staging and classification is presented.

  19. A rare case of rynopharyngeal melanoma

    Directory of Open Access Journals (Sweden)

    Francesco Grecchi

    2012-01-01

    Full Text Available Primary mucosal melanomas (MM of the head and neck region constitute 0.5-2% of all malignant melanomas. The rynopharynx is a region that is less often involved by malignant melanomas. Because most of mucosal melanotic lesions are painless in their early stages, the diagnosis is unfortunately often delayed until symptoms resulting from ulceration, growth, and/or bleeding are noted. Here, we document the rare case of a malignant rynopharynx melanoma of a 43 year old woman. Its treatment and the pertinent literature are discussed. No complication was recorded in the post-operative period and no further surgery was performed. The follow up showed no recurrence in the same position and with the same characteristics, even after six years. Mucosal melanomas are aggressive tumours and the prognosis in these patients is poor. Clinicians must use treatment strategies that provide functional benefit, so as to maintain quality of life without excessive toxicity.

  20. Alpha particles for treatment of disseminated melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Link, E.M. [London University (United Kingdom)

    2010-07-01

    Invading melanoma spreads to local and unpredictable distant location at the early stages of its development. It is justifiable, therefore, to classify the disease as a systemic disorder. This requires a systemic treatment that reaches all melanoma cells irrespective of whether they are singly dispersed and in circulation or already forming solid tumours of various sizes. Targeted radiotherapy affects directly and selectively cancer cells provided an appropriate radionuclide and its carrier are chosen. Melanoma is a pigmented tumour. Methylene blue (MTB)) accumulates selectively in melanoma cells due to its exceptionally high affinity to melanin. MTB serves, therefore, as a carrier for radionuclides. {sup 211}At-MTB has proved to be particularly effective in treating disseminated melanoma when administered systemically and, at the same time, non-toxic to normal non-pigmented and pigmented organs. (authors)

  1. Alpha particles for treatment of disseminated melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Link, E.M. [London Univ. (United Kingdom)

    2010-11-15

    Invading melanoma spreads to local and unpredictable distant location at the early stages of its development. It is justifiable, therefore to classify the disease as a systemic disorder. This requires a systemic treatment that reaches all melanoma cells irrespective of whether they are singly dispersed and in circulation or already forming solid tumours of various sizes. Targeted radiotherapy affects directly and selectively cancer cells provided an appropriate radionuclide and its carrier are chosen. Melanoma is a pigmented tumour. Methylene blue (MTB) accumulates selectively in melanoma cells due to its exceptionally high affinity to melanin. MTB serves, therefore, as a carrier for radionuclides. {sup 211}At-MTB has proved to be particularly effective in treating disseminated melanoma when administered systemically and, at the same time, non-toxic to normal non-pigmented and pigmented organs. (author)

  2. Nanomechanical analysis of pigmented human melanoma cells.

    Science.gov (United States)

    Sarna, Michal; Zadlo, Andrzej; Pilat, Anna; Olchawa, Magdalena; Gkogkolou, Paraskevi; Burda, Kvetoslava; Böhm, Markus; Sarna, Tadeusz

    2013-09-01

    Based on hitherto measurements of elasticity of various cells in vitro and ex vivo, cancer cells are generally believed to be much softer than their normal counterparts. In spite of significant research efforts on the elasticity of cancer cells, only few studies were undertaken with melanoma cells. However, there are no reports concerning pigmented melanoma cells. Here, we report for the first time on the elasticity of pigmented human melanoma cells. The obtained data show that melanin significantly increases the stiffness of pigmented melanoma cells and that the effect depends on the amount of melanin inside the cells. The dramatic impact of melanin on the nanomechanical properties of cells puts into question widely accepted paradigm about all cancer cells being softer than their normal counterparts. Our findings reveal significant limitations of the nanodiagnosis approach for melanoma and contribute to better understanding of cell elasticity. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  3. UVEAL MELANOMA EXTENSION TO THE OPTIC CHIASM.

    Science.gov (United States)

    Abdellatief, Amro; Pulido, Jose S; Bartley, George B; Salomao, Diva R; Quinn, Timothy A

    2016-01-01

    Case report describing a patient who developed intracranial extension of a uveal melanoma through the optic nerve. We reviewed the patient's medical history and images. A 41-year-old woman who was blind in one eye had a uveal melanoma that extended through the optic nerve into the optic chiasm and involved the hypophysis. The patient then developed metastasis. The patient developed uveal melanoma extension into the optic chiasm through the optic nerve resulting in a visual field defect in the fellow eye. Uveal melanoma extension through the optic nerve is a devastating complication, which occurs anywhere from 0.6% to 3.7% in patients with uveal melanoma. If enucleation of the affected eye is performed, a representative portion of the optic nerve should be excised to decrease the risk of extension. Patients with phthisical eyes should undergo appropriate imaging techniques to prevent a missed diagnosis of optic nerve involvement.

  4. Nodular skin melanomas and dermatoscopic diagnostic therein

    Directory of Open Access Journals (Sweden)

    M. V. Zhuchkov

    2016-01-01

    Full Text Available Aim. The study of dermatoscopic pattern characteristics of nodular melanoma with the use of modified Kittler’s pattern analysis. Materials and methods. Clinical and dermatoscopis images of 127 patients with histologically distinctive nodular form of skin melanoma were examined. Nonpolarized dermoscopy of nodular melanoma foci was carried out to patients. Interpretation of obtained dermatoscopic images was performed with the use of pattern analysis modified by Harold Kittler. Main results. The two most important dermatoscopic features of nodular melanoma that distinguish it from other clinical types of this malignant tumor were revealed in our investigation: 1 the prevalence of dermatoscopis images with one pattern (structureless; 2 the prevalence of “grey dots, circles, clods” and “black peripheral dots and clods” as main features of nodular melanoma.

  5. Derechos Humanos fundamentales en la Tecnología Edad : Reflexiones sobre el Post -Humanismo

    Directory of Open Access Journals (Sweden)

    Marcelo Benacchio

    2016-05-01

    Full Text Available Esta investigación pretende destacar el panorama de la tecnología posmoderna que permite la manipulación de la naturaleza humana y sus efectos en los derechos humanos fundamentales. Objetiva con este estudio reflexionar sobre el potencial tecnológico de la posmodernidad frente a los derechos afirmados con el tiempo, en oposición de lo nuevo al tradicional. La técnica de investigación utilizada es la literatura y el enfoque si da por me- dio de los métodos deductivos e inductivos. Se recurre a la obra Biotecnología y Posthu- manismo coordinada por Jesús Ballesteros y Encarnación Fernández para apoyar el tema propuesto. Cabe señalar que las principales amenazas a la dignidad humana adquieren nuevo disfraz. Así, mientras surgen nuevas amenazas la ciencia del derecho debe incorpo- rar nuevas herramientas para cumplir con su papel de proteger a la sociedad.

  6. Melanoma Surveillance in the US: Collecting Melanoma Data

    Centers for Disease Control (CDC) Podcasts

    2011-10-19

    This podcast accompanies the publication of a series of articles on melanoma surveillance in the United States, available in the November supplement edition of the Journal of the American Academy of Dermatology. Dr. Suephy Chen, a dermatologist from Emory University, discusses why the articles are important, as well as the need to increase dermatologists’ awareness of cancer registries and reporting requirements.  Created: 10/19/2011 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 10/19/2011.

  7. El despegue industrial y el papel de los empresarios

    Directory of Open Access Journals (Sweden)

    Luis Aurelio Ordoñez B.

    1997-02-01

    Full Text Available RESUMEN Analiza a la luz de la historiografía económica colombiana, cuáles han sido algunas de las características más ssobresalientes del devenir empresarial en Colombia y el papel que los empresarios han desempeñado en el despegue industrial colombiano.

  8. PARA UNA LECTURA CRÍTICA DEL DESARROLLO HUMANO

    Directory of Open Access Journals (Sweden)

    Melisa Campana

    2013-01-01

    Full Text Available El presente trabajo propone una lectura crítica del discurso del desarrollo humano articulado por Amartya Sen en Desarrollo y Libertad , desde el enfoque de la gubernamentalidad. En primer lugar, se precisa la perspectiva teórica adoptada, haciendo hincapié en las particularidades de la razón gubernamental neoliberal, marco en el que emerge el discurso del desarrollo humano. Se rastrea, luego, un conjunto de premisas del modelo de la elección racional, que brinda elementos conceptuales al discurso del desarrollo humano. A partir de estas claves, se examina una serie de postulados vertebradores de la propuesta de Amartya Sen, a los fines de identificar algunos de los efectos que ha producido el discurso del desarrollo humano en términos de concepción de la pobreza y de los dispositivos de intervención sobre ella.

  9. e implicaciones para el bienestar de los humanos

    Directory of Open Access Journals (Sweden)

    Germán Gutiérrez

    2007-01-01

    Full Text Available En este artículo se revisa la literatura reciente sobre interacciones humano-animal, su origen, sus características y cómo dichas interacciones afectan el bienestar físico, psicológico y social. En la primera parte se presentan los orígenes y evolución histórica de las relaciones humano - animal, empezando por los procesos de domesticación y se aborda la naturaleza de las interacciones humano animal. En la segunda parte, se revisan los efectos para los humanos de la interacción con animales, especialmente con sus mascotas y se analiza la literatura científica sobre los efectos físicos, psicológicos y sociales. Finalmente, se aborda brevemente el desarrollo de esta área de investigación en Latinoamérica.

  10. Sox2 is not required for melanomagenesis, melanoma growth and melanoma metastasis in vivo.

    Science.gov (United States)

    Cesarini, V; Guida, E; Todaro, F; Di Agostino, S; Tassinari, V; Nicolis, S; Favaro, R; Caporali, S; Lacal, P M; Botti, E; Costanzo, A; Rossi, P; Jannini, E A; Dolci, S

    2017-08-01

    Melanoma is a dangerous form of skin cancer derived from the malignant transformation of melanocytes. The transcription factor SOX2 is not expressed in melanocytes, however, it has been shown to be differentially expressed between benign nevi and malignant melanomas and to be essential for melanoma stem cell maintenance and expansion in vitro and in xenograft models. By using a mouse model in which BRaf V600E mutation cooperates with Pten loss to induce the development of metastatic melanoma, we investigated if Sox2 is required during the process of melanomagenesis, melanoma growth and metastasis and in the acquisition of resistance to BRAF inhibitors (BRAFi) treatments. We found that deletion of Sox2 specifically in Pten null and BRafV600E-expressing melanocytes did not prevent tumor formation and did not modify the temporal kinetics of melanoma occurrence compared to Sox2 wt mice. In addition, tumor growth was similar between Sox2 wt and Sox2 deleted (del) melanomas. By querying publicly available databases, we did not find statistically significant differences in SOX2 expression levels between benign nevi and melanomas, and analysis on two melanoma patient cohorts confirmed that Sox2 levels did not significantly change between primary and metastatic melanomas. Melanoma cell lines derived from both Sox2 genotypes showed a similar sensitivity to vemurafenib treatment and the same ability to develop vemurafenib resistance in long-term cultures. Development of vemurafenib resistance was not dependent on SOX2 expression also in human melanoma cell lines in vitro. Our findings exclude an oncogenic function for Sox2 during melanoma development and do not support a role for this transcription factor in the acquisition of resistance to BRAFi treatments.

  11. Current management and novel agents for malignant melanoma

    Directory of Open Access Journals (Sweden)

    Lee Byung

    2012-02-01

    Full Text Available Abstract Advanced malignant melanoma remains a challenging cancer. Over the past year, there have been 3 agents approved for treatment of melanoma by Food and Drug Administration. These include pegylated interferon alpha-2b for stage III melanoma, vemurafenib for unresectable or metastatic melanoma with BRAF V600E mutation, and ipilimumab for treatment of unresectable or metastatic melanoma. This review will also update on the development of novel agents, including tyrosine kinase inhibitors and adoptive cellular therapy.

  12. Papel das Yops secretadas por Yersinia sobre a resposta imune do hospedeiro

    Directory of Open Access Journals (Sweden)

    L. G.S. Monnazzi

    2009-01-01

    Full Text Available

    O gênero Yersinia compreende três espécies patogênicas para humanos: Y. pestis , Y. enterocolitica e Y. pseudotuberculosis . A patogenicidade de Yersinia está ligada à presença do plasmideo de 70-kb (pYV que é comum às três espécies e codifica um sistema de secreção do tipo III e um conjunto de proteínas de virulência, incluindo aquelas conhecidas como Yops (Yersinia outer proteins, que são exportadas por este sistema quando as células do hospedeiro são infectadas pela bactéria. Duas Yops translocadoras (YopB e YopD se inserem na membrana plasmática e funcionam no transporte de seis efetoras (YopO, YopH, YopM, YopJ e YopT para o citosol da célula do hospedeiro. As Yops efetoras funcionam interferindo em múltiplas vias de sinalização da célula infectada. Como conseqüência, a resposta imune inata e adaptativa do hospedeiro fica afetada. Este trabalho enfoca o papel das Yops na modulação da resposta imune do hospedeiro. Palavras-chave: Yersinia ; Yops, fagocitose, citocinas, anticorpos.

  13. O papel do fisiologista desportivo no futebol: para quê & por quê?

    Directory of Open Access Journals (Sweden)

    Paulo Roberto Santos Silva

    2000-08-01

    Full Text Available A fisiologia desportiva ainda é considerada uma especialidade relativamente nova no futebol. A figura do fisiologista desportivo e, conseqüentemente, sua função e formação, é desconhecida pela grande maioria daqueles que estão envolvidos nesta modalidade, não sabendo caracterizar o papel desse profissional numa equipe de futebol. É importante ressaltar que o especialista desta área trabalha diretamente junto ao fisicultor, cabendo a ele funções como: 1 trabalho em equipe passando informações constantes à comissão técnica sobre as condições funcionais dos jogadores; 2 avaliação sistemática dos atletas; 3 acompanhamento longitudinal das adaptações funcionais em decorrência do treinamento dos atletas e 4 capacidade de investigação e reflexão sobre diversos aspectos do futebol. Sendo assim, o fisiologista desportivo requer amplo conhecimento de metodologias científicas de avaliação funcional e treinamento desportivo, bem como o domínio específico de conceitos bioenergéticos direcionados para o futebol. Isso permite identificar o tipo de esforço e selecionar métodos adequados para o desenvolvimento do programa de treinamento do futebolista. Concluindo, o fisiologista desportivo, em sua essência, é sobretudo um profissional de saúde que tem cada vez mais uma função educativa. Ele contribui para melhorar a informação científica que toda a comunidade esportiva deve ter sobre diversos aspectos de saúde do corpo humano e, em particular, quando submetido à realização de exercícios.

  14. Definições teórica e operacional do conceito de papel do enfermeiro

    OpenAIRE

    Trevizan, Maria Auxiliadora; Costa Mendes, Isabel Amélia; Nogueira, Maria Suely

    2008-01-01

    Ao final de uma exploração do conceito de papel, do papel do enfermeiro, e após considerações sobre o elemento de conflito que permeia o papel deste profissional, propõe-se uma definição teórica do papel do enfermeiro e apresenta-se uma tentattiva de opercaionalizá-la.

  15. Ciencia, desarrollo humano y calidad de vida

    Directory of Open Access Journals (Sweden)

    Rocío Calderón García

    2009-01-01

    Full Text Available En la sociedad contemporánea, la ciencia y la tecnología se hanconvertido en el centro alrededor del cual se entretejen las rela-ciones sociales y la vida social. La sociedad del conocimiento,como se le ha denominado al modelo de la sociedad a la que as-piraríamos, precisamente por el desarrollo que ha tenido el cono-cimiento tecnológico y cientíęco en estos momentos, se convierteen el ámbito natural para que el tema de la tecnociencia formeparte de los procesos formativos y constitutivos de las nuevasidentidades sociales. El hecho de entender como la poblaciónincorpora los conceptos de ciencia y tecnología en sus agendasde discusión en la toma de decisiones sobre su vida y en sus ac-tividades cotidianas, se convierte hoy en día en una explicaciónnecesaria para entender los procesos de formación y expresióndel ser humano contemporáneo.

  16. BUCLE ENTRE LAICIDAD Y DERECHOS HUMANOS

    Directory of Open Access Journals (Sweden)

    Felipe Gaytán Alcalá

    2014-06-01

    Full Text Available La laicidad como referente del espacio público y del marco jurídico de la ciudadanía se ha vuelto un tema de debate político en el mundo, particularmente en América Latina. Va más allá de la separación entre Estado e Iglesias y el discurso anticlerical. La Laicidad es un debate sobre los derechos y libertades civiles de los ciudadanos en el respeto de sus derechos humanos por parte de organizaciones, cultos, creencias religiosas. Diversos estudios se han impulsado en este marco de reflexión, estudios que transitan las fronteras entre lo académico, político, militancia social, etc. En el presente texto abordamos las diversas formas que el concepto ha tenido en AL y las implicaciones en la narrativa de los DH y la diversidad cultural. Particularmente analizaremos tres enfoques de la laicidad no excluyentes entres sí: uno de ellos refiere a la laicidad inclusiva en el espacio público, la segunda entiende la laicidad como garante de la autonomía de lo político marcando una exclusión entre creencia y ciudadanía y; la tercera, predominante en la región, subraya la autonomía del Estado frente a las organizaciones religiosas expresada en la separación Estado- Iglesias.

  17. Quilombolas e direitos humanos no Suriname

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    Richard Price

    1999-05-01

    Full Text Available Resumo Desde a independência do Suriname em 1975, o relacionamento entre o Estado e sua população quilombola (cerca de 52 mil pessoas, talvez 15% da população nacional deteriorou. Do ponto de vista quilombola, os tipos de atrocidades associadas às guerras coloniais do século dezoito voltaram à tona. A Guerra Civil que começou em 1986, que jogou o exército nacional contra os “Jungle Commandos” (compostos principalmente de quilombolas só fez piorar a situação dos quilombolas. Um grande julgamento pela Corte Inter-Americana de Direitos Humanos em 1992, tendo como réu o Estado do Suriname, terminou com uma vultosa indenização por danos aos quilombolas Saramaka, autores da queixa. Recentemente a situação piorou, quando os quilombolas – sem qualquer proteção legal sob a constituição do Suriname – viram as terras pelas quais os seus antepassados lutaram e morreram serem confiscadas unilateralmente pelo Estado e doadas, em concessões gigantescas, a companhias madeireiras e mineradoras multinacionais (da Indonésia, da Malásia, da China e do Canadá. O efeito das atuais políticas para os quilombolas não é nada menos do que etnocídio.

  18. Los derechos humanos en el franquismo

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    Josefa Dolores Ruiz Resa

    2014-06-01

    Full Text Available Durante el régimen franquista se reconocieron, en diversos textos jurídicos como el Fuero del Trabajo (1938 o el Fuero de los Españoles (1945, una serie de derechos. Entre ellos se encuentran, por ejemplo, el derecho al trabajo, a participar en las funciones públicas, entre otros. En este artículo se hace una revisión histórica con el objetivo de determinar sobre qué presupuestos ideológicos se basó la concepción de los derechos durante el franquismo, cómo se justificó su reconocimiento en una dictadura que se había declarado contraria a las doctrinas modernas que habían servido para reivindicar los derechos humanos (es decir, el constitucionalismo, el liberalismo político o la socialdemocracia, y con qué diseño y alcance legal fueron reconocidos aquellos derechos.

  19. POBREZA MUNDIAL, JUSTICIA Y DERECHOS HUMANOS

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    Mauricio Andrés Gallo Callejas

    2010-11-01

    Full Text Available En este escrito pregunto por el estatus normativo que, bajo nuestras creencias actuales, debemos dar a la situación de millones de personas condenadas a pasar una vida en condiciones de pobreza extrema alrededor de todo el planeta. Asunto frente al cual formulo las siguientes dos tesis: (i la construcción de juicios normativos que nos permitan redescribir el sentido valorativo que estamos dando a su situación no sólo es posible, sino que es nuestro deber. Tal redescripción significa incluir su dolor y sufrimiento dentro de los asuntos dejusticia política global que incumben a toda la comunidad de seres humanos. Y (ii dicha redescripción, o lo que es igual, otorgar este nuevo estatus normativo a la pobreza mundial no nos exige ni proponer la creación de instituciones que, como la república mundial o principios globales de justicia distributiva, ponganen peligro el valor de los actuales Estados nación, ni mucho menos, justificar la violencia como herramienta de lucha política en búsqueda de la corrección moralde dichas instituciones.

  20. Los derechos humanos y el medioambiente

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    Juan José Rodríguez Beltrán

    2006-01-01

    Full Text Available Los derechos humanos son individuales, esenciales, inalienables e inherentes a la dignidad de la persona humana, constituyen la base del Estado social de derecho, y son anteriores al derecho positivo. Por su parte, hay otro tipo de derechos que son los colectivos, los cuales radican en cabeza del colectivo social y están ligados a la calidad de vida de las personas. Existe una estrecha relación entre los unos y los otros, pero el interrogante radica en saber cuál prevalece; en la actualidad podría hablarse de una colisión o conflicto que se está presentando entre ambos, esto hace pensar hasta qué punto el crecimiento industrial y tecnológico del mundo es permisible en la medida en que se está comprometiendo el medioambiente y el equilibrio ecológico, lo cual va en detrimento de los derechos a la vida, a la salud y como fundamento último de la persona misma.

  1. Future perspectives in melanoma research

    Directory of Open Access Journals (Sweden)

    Paolo A. Ascierto

    2016-11-01

    Full Text Available Abstract The sixth “Melanoma Bridge Meeting” took place in Naples, Italy, December 1st–4th, 2015. The four sessions at this meeting were focused on: (1 molecular and immune advances; (2 combination therapies; (3 news in immunotherapy; and 4 tumor microenvironment and biomarkers. Recent advances in tumor biology and immunology has led to the development of new targeted and immunotherapeutic agents that prolong progression-free survival (PFS and overall survival (OS of cancer patients. Immunotherapies in particular have emerged as highly successful approaches to treat patients with cancer including melanoma, non-small cell lung cancer (NSCLC, renal cell carcinoma (RCC, bladder cancer, and Hodgkin’s disease. Specifically, many clinical successes have been using checkpoint receptor blockade, including T cell inhibitory receptors such as cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4 and the programmed cell death-1 (PD-1 and its ligand PD-L1. Despite demonstrated successes, responses to immunotherapy interventions occur only in a minority of patients. Attempts are being made to improve responses to immunotherapy by developing biomarkers. Optimizing biomarkers for immunotherapy could help properly select patients for treatment and help to monitor response, progression and resistance that are critical challenges for the immuno-oncology (IO field. Importantly, biomarkers could help to design rational combination therapies. In addition, biomarkers may help to define mechanism of action of different agents, dose selection and to sequence drug combinations. However, biomarkers and assays development to guide cancer immunotherapy is highly challenging for several reasons: (i multiplicity of immunotherapy agents with different mechanisms of action including immunotherapies that target activating and inhibitory T cell receptors (e.g., CTLA-4, PD-1, etc.; adoptive T cell therapies that include tissue infiltrating lymphocytes (TILs, chimeric

  2. Melanoma early detection and awareness

    DEFF Research Database (Denmark)

    Wainstein, Alberto; Algarra, Salvador Martin; Bastholt, Lars

    2014-01-01

    Risk factors for melanoma are well known and have guided plans for primary and secondary prevention. The presentation of the disease, however, varies widely depending on the geographic area, ethnicity, and socioeconomic status. For this reason, many countries have developed specific strategies to...... are trying to implement similar measures. Future efforts to further improve the efficacy of preventive strategies should focus on populations that usually escape campaigns, such as elderly men and people with low socioeconomic status. Fast-growing tumors also require specific attention....

  3. PERCEPÇÃO NO AMBIENTE ACADÊMICO SOBRE SUSTENTABILIDADE AMBIENTAL E O USO DO PAPEL

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    Maria de Fátima Costa Cabral Peixoto

    2013-10-01

    Full Text Available A sustentabilidade ambiental requer a reorientação da lógica produtivista aliada à mudança de atitudes por parte dos atores sociais nas diversas instâncias de sua atuação. A partir desta compreensão, avalia-se a percepção ambiental de atores sociais, docentes e discentes de cursos superiores, quanto aos temas percepção, sustentabilidade, impactos ambientais e sua relação com a produção, uso, descarte e reciclagem do papel branco, insumo utilizado na transmissão de conhecimentos. Aplicou-se questionários semiestruturados a docentes e discentes de dois cursos superiores de duas instituições situadas no município de Patos(PB. Prepondera a visão globalizante, reconhecendo a interrelação entre o ser humano e a natureza. Nos projetos de pesquisa e extensão, verificou-se o distanciamento em relação à temática ambiental e, especificamente, a ausência de uma postura ambientalmente ativa, em relação ao descarte seletivo do papel utilizado em suas atividades acadêmicas. O nível de abordagem que prepondera é a discussão em sala de aula. As institições de ensino superior precisam criar uma política que sensibilize estes atores sociais para as questões ambientais iniciando no próprio ambiente acadêmico e, quando já existirem estas iniciativas, que haja um envolvimento do corpo docente e da direção da instituição no sentido de implementá-la com maiores chances de êxito.

  4. Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors

    DEFF Research Database (Denmark)

    Boyle, Jenny L; Haupt, Helen M; Stern, Jere B

    2002-01-01

    CONTEXT: Pathologists may encounter problems in the differential diagnosis of malignant melanoma, spindle and epithelioid neoplasms of peripheral nerves, and fibrohistiocytic tumors. Tyrosinase has been demonstrated to be a sensitive marker for melanoma. OBJECTIVE: To determine the specificity...... of tyrosinase expression in the differential diagnosis of melanoma, desmoplastic melanoma, and peripheral nerve sheath tumors. DESIGN: Immunoreactivity for tyrosinase, HMB-45 (anti-gp100 protein), S100 protein, CD34, and vimentin was studied in 70 tumors, including 15 melanomas (5 desmoplastic, 4 amelanotic, 6...... at 121 degrees C. RESULTS: All melanomas demonstrated positive immunostaining for tyrosinase, HMB-45, and S100 protein. Immunoreactivity for HMB-45 was generally stronger than that for tyrosinase in amelanotic lesions and significantly stronger in 1 of the desmoplastic lesions. The 4 pigmented...

  5. HLA y expresión de receptores NK en pacientes con melanoma

    OpenAIRE

    García Alonso, Ana María

    2016-01-01

    El melanoma cutáneo es una neoplasia maligna de los melanocitos que se caracteriza por un curso clínico a menudo indeseable. Aunque actualmente la detección precoz y la cirugía ofrecen una alta tasa de curación, este tumor puede eludir la vigilancia inmunológica del huésped favoreciendo su evolución. Esto puede deberse ciertas interacciones entre los antígenos leucocitarios humanos (HLA) y células T citolíticas específicas de antígeno (CTL) o las células asesinas naturales (NK), las cuales so...

  6. El papel de la imaginación en la refutación de Adam Smith a la tesis del homo economicus

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    José de la Cruz Garrido

    2015-01-01

    Full Text Available La filosofía moral de Adam Smith se fundamenta en el papel de la imaginación para explicar el orden social en un nivel macro, y como mecanismo de identificación afectiva en un nivel micro. En ambos casos, el rol de la imaginación en nuestra psicología moral refuta la tesis de un homo economicus, o de que el ser humano está motivado a entrar en sociedad por su interés personal. Esto sirve de premisa para refutar la posición hobbesiana de un estado de naturaleza histórico que está en la base de nuestros juicios morales que fundan la sociedad civil y la necesidad del magistrado.

  7. Pregnancy promotes melanoma metastasis through enhanced lymphangiogenesis.

    Science.gov (United States)

    Khosrotehrani, Kiarash; Nguyen Huu, Sau; Prignon, Aurélie; Avril, Marie-Françoise; Boitier, Françoise; Oster, Michèle; Mortier, Laurent; Richard, Marie-Aleth; Maubec, Eve; Kerob, Delphine; Mansard, Sandrine; Merheb, Charbel; Moguelet, Philippe; Nassar, Dany; Guégan, Sarah; Aractingi, Selim

    2011-04-01

    The relationships of pregnancy and melanoma have been debatable. Our aim was to assess the influence of gestation on the course of melanoma in a classic murine model of tumor progression and in women. B16 mouse melanoma cells were injected in nonpregnant or pregnant mice on day 5 of gestation. Animals were evaluated for tumor progression, metastases, and survival. Tumor sections were analyzed for lymphatic and blood vessel number and relative surface and expression of angiogenic growth factors. Finally, primary melanomas from pregnant and nonpregnant women, matched for age and tumor thickness, were also considered. Tumor growth, metastasis, and mortality were increased in B16-injected pregnant mice. Tumors displayed an increase in intratumoral lymphangiogenesis during gestation. This increased lymphatic angiogenesis was not observed in normal skin during gestation, showing its specificity to the tumor. An analysis of melanoma from pregnant and matched nonpregnant women showed a similar increase in lymphatic vessels. Tumors from pregnant mice had increased expression of vascular endothelial growth factor A at the RNA and protein levels. The increased vascular endothelial growth factor A production by melanoma cells could be reproduced in culture using pregnant mouse serum. In conclusion, pregnancy results in increased lymphangiogenesis and subsequent metastasis. Caution should be applied in the management of patients with advanced-stage melanoma during gestation. Copyright © 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  8. Non Melanoma Skin Cancer Pathogenesis Overview.

    Science.gov (United States)

    Didona, Dario; Paolino, Giovanni; Bottoni, Ugo; Cantisani, Carmen

    2018-01-02

    (1) Background: Non-melanoma skin cancer is the most frequently diagnosed cancer in humans. The process of skin carcinogenesis is still not fully understood. However, several studies have been conducted to better explain the mechanisms that lead to malignancy; (2) Methods: We reviewed the more recent literature about the pathogenesis of non-melanoma skin cancer focusing on basal cell carcinomas, squamous cell carcinoma and actinic keratosis; (3) Results: Several papers reported genetic and molecular alterations leading to non-melanoma skin cancer. Plenty of risk factors are involved in non-melanoma skin cancer pathogenesis, including genetic and molecular alterations, immunosuppression, and ultraviolet radiation; (4) Conclusion: Although skin carcinogenesis is still not fully understood, several papers demonstrated that genetic and molecular alterations are involved in this process. In addition, plenty of non-melanoma skin cancer risk factors are now known, allowing for an effective prevention of non-melanoma skin cancer development. Compared to other papers on the same topic, our review focused on molecular and genetic factors and analyzed in detail several factors involved in non-melanoma skin cancer.

  9. Melanoma Brain Metastasis: Mechanisms, Models, and Medicine

    Science.gov (United States)

    Kircher, David A.; Silvis, Mark R.; Cho, Joseph H.; Holmen, Sheri L.

    2016-01-01

    The development of brain metastases in patients with advanced stage melanoma is common, but the molecular mechanisms responsible for their development are poorly understood. Melanoma brain metastases cause significant morbidity and mortality and confer a poor prognosis; traditional therapies including whole brain radiation, stereotactic radiotherapy, or chemotherapy yield only modest increases in overall survival (OS) for these patients. While recently approved therapies have significantly improved OS in melanoma patients, only a small number of studies have investigated their efficacy in patients with brain metastases. Preliminary data suggest that some responses have been observed in intracranial lesions, which has sparked new clinical trials designed to evaluate the efficacy in melanoma patients with brain metastases. Simultaneously, recent advances in our understanding of the mechanisms of melanoma cell dissemination to the brain have revealed novel and potentially therapeutic targets. In this review, we provide an overview of newly discovered mechanisms of melanoma spread to the brain, discuss preclinical models that are being used to further our understanding of this deadly disease and provide an update of the current clinical trials for melanoma patients with brain metastases. PMID:27598148

  10. Dermoscopy on subungual melanoma 

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    Grażyna Kamińska-Winciorek

    2013-05-01

    Full Text Available Subungual melanoma is a rare, but one of the diagnostically most difficult variants of melanoma. Unfortunately, due to its late detection, lack of an early reaction from the patient and diagnosis in advanced stages, subungual melanoma is deemed as a prognostically unfavorable variant of this malignancy. Diagnosis of subungual melanoma is very difficult to establish merely on the basis of clinical examination due to the resemblance of subungual hematoma to melanocytic nevus, fungal or bacterial infections. Dermoscopy seems to be the ideal diagnostic tool in the differential diagnosis of this life-threatening disease. Aims. To describe the basic aspects of dermoscopy of subungual melanoma and other conditions involving the nails. Methods. Review of medical database PubMed for the literature of the last 10 years on the dermoscopic patterns of subungual melanoma and other subungual diseases. Results. We collate the fundamental rules of performing dermoscopy in subungual melanoma, as well as basic dermoscopic features and diagnostic algorithms of selected subungual lesions requiring differentiation from melanoma. Conclusions. Dermoscopy is a safe, easily repeatable diagnostic method, and the knowledge of basic dermoscopic patterns of developing melanoma in subungual localization, along with the differential diagnosis of other diseases within the nail plate, will help not only dermatologists, but also the professionals of other specialties, such as surgeons, oncologists, orthopedists, and also general practitioners.

  11. Whole Body Melanoma Transcriptome Response in Medaka.

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    Manfred Schartl

    Full Text Available The incidence of malignant melanoma continues to increase each year with poor prognosis for survival in many relapse cases. To reverse this trend, whole body response measures are needed to discover collaborative paths to primary and secondary malignancy. Several species of fish provide excellent melanoma models because fish and human melanocytes both appear in the epidermis, and fish and human pigment cell tumors share conserved gene expression signatures. For the first time, we have examined the whole body transcriptome response to invasive melanoma as a prelude to using transcriptome profiling to screen for drugs in a medaka (Oryzias latipes model. We generated RNA-seq data from whole body RNA isolates for controls and melanoma fish. After testing for differential expression, 396 genes had significantly different expression (adjusted p-value <0.02 in the whole body transcriptome between melanoma and control fish; 379 of these genes were matched to human orthologs with 233 having annotated human gene symbols and 14 matched genes that contain putative deleterious variants in human melanoma at varying levels of recurrence. A detailed canonical pathway evaluation for significant enrichment showed the top scoring pathway to be antigen presentation but also included the expected melanocyte development and pigmentation signaling pathway. Results revealed a profound down-regulation of genes involved in the immune response, especially the innate immune system. We hypothesize that the developing melanoma actively suppresses the immune system responses of the body in reacting to the invasive malignancy, and that this mal-adaptive response contributes to disease progression, a result that suggests our whole-body transcriptomic approach merits further use. In these findings, we also observed novel genes not yet identified in human melanoma expression studies and uncovered known and new candidate drug targets for further testing in this malignant melanoma

  12. Endothelin role in the orthostatic stress Papel da endotelina no estresse ortostático

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    Marli Cardoso Martins Pinge

    2008-10-01

    e, juntamente com componentes hormonais, amplia a capacidade de adaptação frente a mudanças posturais. Qualquer dificuldade nesse mecanismo compensatório que impeça seu funcionamento adequado pode resultar em falha da resposta com hipotensão, que, por sua vez, pode levar à hipoperfusão cerebral, hipóxia e perda de consciência. A manutenção da pressão arterial em níveis normais é importante para a homeostasia do meio interno. O barorreflexo desempenha papel fundamental no controle cardiovascular a curto-prazo na adaptação ao estresse ortostático, e prevendo excessivas flutuações da pressão arterial. Durante o estresse ortostático, também ocorrem mudanças neuroendócrinas como alteração nos níveis plasmáticos de endotelina. A endotelina, peptídeo composto de 21 aminoácidos, apresenta potente ação vasoconstritora. Tem sido sugerido um papel para a endotelina, já que está demonstrado que seus níveis no sangue estão aumentados em resposta a um estresse ortostático. Entretanto, embora os níveis de endotelina-1 aumentem em resposta ao estresse postural agudo, seu papel na homeostase cardiovascular e sua relação na liberação de outros hormônios ainda permanecem controversos e bastante desconhecidos em humanos in vivo.

  13. Plasma 25-Hydroxyvitamin D and Risk of Non-Melanoma and Melanoma Skin Cancer

    DEFF Research Database (Denmark)

    Afzal, Shoaib; Nordestgaard, Børge G; Bojesen, Stig E

    2013-01-01

    with increasing cumulative incidence of non-melanoma skin cancer (trend P=2 × 10(-15) and P=3 × 10(-17)) and melanoma skin cancer (P=0.003 and P=0.001). Multivariable adjusted hazard ratios of non-melanoma skin cancer were 5.04 (95% confidence interval (CI): 2.78-9.16) for 25-OH-vitD 50 vs. 60 years, 25-OH...

  14. Primary retroperitoneal melanoma presented in a rare extracutaneous site for malignant melanoma

    Directory of Open Access Journals (Sweden)

    Mohamed Alsharedi

    2016-10-01

    Full Text Available Malignant melanoma, as the name implies, is a malignant tumor of melanocytes, found in the skin, eyes, meningeal lining and the mucosal epithelium of the aero-digestive and genitourinary tracts. Malignant melanoma is typically skin malignancy, which rarely presents at extracutaneous site. Here we present a rare case of primary retroperitoneal melanoma and review the findings in comparison with other cases described in literature.

  15. Identification of an Immunogenic Subset of Metastatic Uveal Melanoma.

    Science.gov (United States)

    Rothermel, Luke D; Sabesan, Arvind C; Stephens, Daniel J; Chandran, Smita S; Paria, Biman C; Srivastava, Abhishek K; Somerville, Robert; Wunderlich, John R; Lee, Chyi-Chia R; Xi, Liqiang; Pham, Trinh H; Raffeld, Mark; Jailwala, Parthav; Kasoji, Manjula; Kammula, Udai S

    2016-05-01

    Uveal melanoma is a rare melanoma variant with no effective therapies once metastases develop. Although durable cancer regression can be achieved in metastatic cutaneous melanoma with immunotherapies that augment naturally existing antitumor T-cell responses, the role of these treatments for metastatic uveal melanoma remains unclear. We sought to define the relative immunogenicity of these two melanoma variants and determine whether endogenous antitumor immune responses exist against uveal melanoma. We surgically procured liver metastases from uveal melanoma (n = 16) and cutaneous melanoma (n = 35) patients and compared the attributes of their respective tumor cell populations and their infiltrating T cells (TIL) using clinical radiology, histopathology, immune assays, and whole-exomic sequencing. Despite having common melanocytic lineage, uveal melanoma and cutaneous melanoma metastases differed in their melanin content, tumor differentiation antigen expression, and somatic mutational profile. Immunologic analysis of TIL cultures expanded from these divergent forms of melanoma revealed cutaneous melanoma TIL were predominantly composed of CD8(+) T cells, whereas uveal melanoma TIL were CD4(+) dominant. Reactivity against autologous tumor was significantly greater in cutaneous melanoma TIL compared with uveal melanoma TIL. However, we identified TIL from a subset of uveal melanoma patients which had robust antitumor reactivity comparable in magnitude with cutaneous melanoma TIL. Interestingly, the absence of melanin pigmentation in the parental tumor strongly correlated with the generation of highly reactive uveal melanoma TIL. The discovery of this immunogenic group of uveal melanoma metastases should prompt clinical efforts to determine whether patients who harbor these unique tumors can benefit from immunotherapies that exploit endogenous antitumor T-cell populations. Clin Cancer Res; 22(9); 2237-49. ©2015 AACR. ©2015 American Association for Cancer Research.

  16. Coping strategies in melanoma patients.

    Science.gov (United States)

    Trapp, Michael; Trapp, Eva-Maria; Richtig, Erika; Egger, Josef Wilhelm; Zampetti, Anna; Sampogna, Francesca; Rohrer, Peter Michael; Komericki, Peter; Strimitzer, Tanja; Linder, Michael Dennis

    2012-11-01

    An observational, questionnaire-based, cross-sectional study was performed to assess whether differences in coping behaviour (positive and negative strategies) between patients with either a recent diagnosis of malignant melanoma (MM) or with benign dermatological disease, were predictive of the diagnosis. Coping strategies were assessed with the German version of the stress-coping questionnaire (SVF 120) in 46 inpatients for whom surgery was planned at the Department of Dermatology, Medical University of Graz, Austria. Subjects were divided into two groups: patients with non-metastatic MM, and patients with benign dermatological diseases (controls). The risk for the diagnosis "melanoma" decreased with higher values of "situation control" (p = 0.007) and increased with higher values of resignation (p = 0.035) and trivialisation (p = 0.039). More-over, the risk for having a MM with thickness > 1 mm decreased in patients with higher values in positive coping strategies (p psychological interventions to improve coping in patients with MM, as differences in coping behaviour seem to appear even in the non-metastatic stage of the disease.

  17. Karen Horney, una pionera de la ruptura con el modelo freudiano para explicar la psicología femenina y el desarrollo humano sano y neurótico

    OpenAIRE

    Vallejo Orellana, Reyes

    2002-01-01

    Karen Horney representa en la historia del psicoanálisis un personaje muy debatido, pues se opuso a las teorías biologistas y organísmicas freudianas, defendiendo un modelo interaccionista donde lo cultural toma un papel preponderante a la hora de explicar las claves del desarrollo humano y de la psicología de la mujer, superando las estrecheces anteriores. La revisión de todo ello es el objeto de este trabajo, con el que se trata de rendir un homenaje a la principal responsable del psicoanál...

  18. Gingival osteogenic melanoma in two dogs.

    Science.gov (United States)

    Ellis, Angela E; Harmon, Barry G; Miller, Debra L; Northrup, Nicole C; Latimer, Kenneth S; Uhl, Elizabeth W

    2010-01-01

    Osteogenic melanoma is a rare variant of metaplastic malignant melanoma in human medicine and appears to be a similarly rare variant in dogs. Two dogs with oral malignant melanoma with neoplastic bone formation are reported in this study. Both tumors were characterized by malignant melanocytes that transitioned into neoplastic bone at the deep margins of the neoplasm. Immunohistochemical analysis revealed S100- and Melan-A-positive neoplastic cells adjacent to, and occasionally embedded within, an osteoid and chondroblastic matrix. Scattered clusters of neoplastic cells were also positive for osteocalcin. The findings indicate that in dogs, as in humans, neoplastic melanocytes have metaplastic potential and can be osteogenic.

  19. Immunotherapy for advanced melanoma: future directions.

    Science.gov (United States)

    Valpione, Sara; Campana, Luca G

    2016-02-01

    As calculated by the meta-analysis of Korn et al., the prognosis of metastatic melanoma in the pretarget and immunological therapy era was poor, with a median survival of 6.2 and a 1-year life expectancy of 25.5%. Nowadays, significant advances in melanoma treatment have been gained, and immunotherapy is one of the promising approaches to get to durable responses and survival improvement. The aim of the present review is to highlight the recent innovations in melanoma immunotherapy and to propose a critical perspective of the future directions of this enthralling oncology subspecialty.

  20. A modified COMS plaque for iris melanoma

    Directory of Open Access Journals (Sweden)

    Daniel J. Scanderbeg

    2011-09-01

    Full Text Available Melanoma of the iris is a rare condition compared to posterior ocular tumors and in this case report we presenta 51-year-old female patient with diffuse iris melanoma. Traditional COMS (Collaborative Ocular Melanoma Studyplaques are used at our institution for radiation therapy, so a novel modification of the traditional plaque was requiredto allow better conformance with placement on the cornea. The usual silastic insert was machined to dimensions incompliance with the cornea, placed without incident, and treatment delivered with excellent patient tolerance of themodified plaque.

  1. Epidemiology of uveal melanomas in Moscow

    Directory of Open Access Journals (Sweden)

    E. E. Grishina

    2017-01-01

    Full Text Available Rationale: Melanoma of the uveal tract of the eye is among the most prevalent malignant intraocular tumors.Aim: To identify epidemiological characteristics of uveal melanoma in Moscow.Materials and methods: We performed a retrospective analysis of out-patient files and follow-up charts of patients with uveal melanoma in the Ophthalmological Clinical Hospital of the Department of Healthcare, Moscow, from 1977 to 2012.Results: Within 36 years, 2547 patients with uveal melanoma have been registered, at the age of 16 to 92 years. The male to female ratio was 1:1.5. The rate of patient referrals with subsequent diagnosis of uveal melanoma has not changed from 1977 to 2000 and was on average 1.07 persons per 100,000 of the adult population. From 2001 to 2012, there was some decline in the number of referrals with uveal melanoma to the average of 0.9 persons per 100,000 of the adult population. We analyzed survival among 359 patients with uveal melanoma after enucleation surgery of the eye; 37% of them were men (63.2 ± 1.8 years and 63% women (69.5 ± 2.7 years. Their 5-year metastasis-free survival was 65 ± 3%, whereas the 7-year survival was 60 ± 4%. The mean time to death was 5.5 years. There were no association between the life longevity and patients gender, but their survival was associated with the age of patients. The risk of death from metastatic uveal melanoma among patients above 60 years of age was on average 10% higher. After the enucleation surgery, patients with Т4 melanoma lived significantly less than those with Т1-3 tumor (5 and 6.5 years, respectively; р = 0.05.Conclusion: The rates of diagnosis of uveal melanoma at referrals within 36 years did not increased. Epidemiology of uveal melanoma in Moscow is characterized by a high proportion of elderly women. Shorter overall and metastasis-free survival of patients with uveal melanoma after the enucleation surgery depends from a higher proportion

  2. Nodular Melanoma Mimicking Keratoacanthoma: Lessons to learn.

    Science.gov (United States)

    Muthupalaniappen, Leelavathi; Das, Srijit; Md Nor, Norazirah; Ali, Siti A M

    2012-08-01

    A 67-year-old man of Chinese descent presented with a painless nodular lesion that had been present on his right forearm for the previous 3 months. A single, well-defined, dome-shaped, firm nodule with a central keratin plug surrounded by erythema was noted. Keratoacanthoma with secondary bacterial infection was suspected and the patient underwent an excision biopsy. Biopsy of the nodule and immunohistochemical staining supported a diagnosis of nodular malignant melanoma. It should be noted both that nodular malignant melanoma may present with a wide variety of clinical appearances, and that the lack of melanin pigment in nodular malignant melanoma may hinder the diagnosis of this aggressive tumour.

  3. Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma.

    Science.gov (United States)

    Simpson, R Mark; Bastian, Boris C; Michael, Helen T; Webster, Joshua D; Prasad, Manju L; Conway, Catherine M; Prieto, Victor M; Gary, Joy M; Goldschmidt, Michael H; Esplin, D Glen; Smedley, Rebecca C; Piris, Adriano; Meuten, Donald J; Kiupel, Matti; Lee, Chyi-Chia R; Ward, Jerrold M; Dwyer, Jennifer E; Davis, Barbara J; Anver, Miriam R; Molinolo, Alfredo A; Hoover, Shelley B; Rodriguez-Canales, Jaime; Hewitt, Stephen M

    2014-01-01

    Melanoma represents a significant malignancy in humans and dogs. Different from genetically engineered models, sporadic canine melanocytic neoplasms share several characteristics with human disease that could make dogs a more relevant preclinical model. Canine melanomas rarely arise in sun-exposed sites. Most occur in the oral cavity, with a subset having intra-epithelial malignant melanocytes mimicking the in situ component of human mucosal melanoma. The spectrum of canine melanocytic neoplasia includes benign lesions with some analogy to nevi, as well as invasive primary melanoma, and widespread metastasis. Growing evidence of distinct subtypes in humans, differing in somatic and predisposing germ-line genetic alterations, cell of origin, epidemiology, relationship to ultraviolet radiation and progression from benign to malignant tumors, may also exist in dogs. Canine and human mucosal melanomas appear to harbor BRAF, NRAS, and c-kit mutations uncommonly, compared with human cutaneous melanomas, although both species share AKT and MAPK signaling activation. We conclude that there is significant overlap in the clinical and histopathological features of canine and human mucosal melanomas. This represents opportunity to explore canine oral cavity melanoma as a preclinical model. © 2013 The Authors. Pigment Cell & Melanoma Research published by John Wiley & Sons Ltd.

  4. Obesity as a risk factor for malignant melanoma and non-melanoma skin cancer.

    Science.gov (United States)

    Karimi, K; Lindgren, T H; Koch, C A; Brodell, Robert T

    2016-09-01

    The dramatic increases in incidence of both obesity and many cancers including skin cancer emphasize the need to better understand the pathophysiology of both conditions and their connections. Melanoma is considered the fastest growing cancer and rates of non-melanoma skin cancer have also increased over the last decade. The molecular mechanisms underlying the association between obesity and skin cancer are not clearly understood but emerging evidence points to changes in the tumor microenvironment including aberrant cell signaling and genomic instability in the chronic inflammatory state many obese individuals experience. This article reviews the literature linking obesity to melanoma and non-melanoma skin cancer.

  5. Experimental boron neutron capture therapy for melanoma: Systemic delivery of boron to melanotic and amelanotic melanoma

    International Nuclear Information System (INIS)

    Coderre, J.A.; Glass, J.D.; Micca, P.; Greenberg, D.; Packer, S.

    1990-01-01

    The boron-containing melanin precursor analogue p-boronophenylalanine (BPA) has previously been shown to selectively deliver boron to pigmented murine melanomas when administered in a single intragastric dose. If boron neutron capture therapy is to become a clinically useful method of radiation therapy for human malignant melanoma, the boron carrier must be capable of delivering useful amounts of boron to remote tumor sites (metastases) and to poorly pigmented melanomas. The authors have now determined the ability of BPA to accumulate in several nonpigmented melanoma models including human melanoma xenografts in nude mice. The absolute amount of boron in the nonpigmented melanomas was about 50% of the observed in the pigmented counterparts but was still selectively concentrated in the tumor relative to normal tissues in amounts sufficient for effective neutron capture therapy. Single intragastric doses of BPA resulted in selective localization of boron in the amelanotic Greene melanoma carried in the anterior chamber of the rabbit eye and in a pigmented murine melanoma growing in the lungs. The ratio of the boron concentration in these tumors to the boron concentration in the immediately adjacent normal tissue was in the range of 3:1 to 4:1. These distribution studies support the proposal that boron neutron capture therapy may be useful as a regional therapy for malignant melanoma

  6. Nestin is expressed in HMB-45 negative melanoma cells in dermal parts of nodular melanoma.

    Science.gov (United States)

    Kanoh, Maho; Amoh, Yasuyuki; Tanabe, Kenichi; Maejima, Hideki; Takasu, Hiroshi; Katsuoka, Kensei

    2010-06-01

    Nestin, a marker of neural stem cells, is expressed in the stem cells of the mouse hair follicle. The nestin-expressing hair follicle stem cells can differentiate into neurons, glia, keratocytes, smooth muscle cells and melanocytes in vitro. These pluripotent nestin-expressing stem cells are keratin 15 (K15)-negative, suggesting that they are in a relatively undifferentiated state. Recent studies suggest that the epithelial stem cells are important in tumorigenesis, and nestin expression is thought to be important in tumorigenesis. In the present study, we examined the expression of the hair follicle and neural stem cell marker nestin, as well as S-100 and HMB-45, in melanoma. Nestin immunoreactivity was observed in the HMB-45-negative melanoma cells in all five cases of amelanotic nodular melanomas. Moreover, nestin immunoreactivity was observed in the dermal parts in seven of 10 cases of melanotic nodular melanomas. Especially, nestin immunoreactivity was observed in the HMB-45-negative melanoma cells in the dermal parts of all 10 cases of HMB-45-negative amelanotic and melanotic nodular melanomas. On the other hand, nestin expression was negative in 10 of 12 cases of superficial spreading melanoma. These results suggest that nestin is an important marker of HMB-45-negative melanoma cells in the dermal parts of patients with nodular melanoma.

  7. É preciso salvar os direitos humanos!

    Directory of Open Access Journals (Sweden)

    José Augusto Lindgren Alves

    2012-01-01

    Full Text Available Os direitos humanos se encontram em fase de evidente desprestígio. Os motivos do descrédito não são apenas as violações que prosseguem, nem distorções decorrentes de valores não ocidentais. São também, e sobretudo, sua extensão conceitual exagerada, promovida pela esquerda culturalista pós-moderna, assim como a repetição inercial de ações e posturas, hoje anacrônicas, inerentes ao sistema de proteção internacional existente. Para recuperá-los em sentido construtivo é necessário voltar à Declaração Universal de 1948, atualizar o discurso originalmente construído contra ditaduras e readaptar o sistema à situação das democracias atuais ameaçadas.Human rights are now in an evident lackluster phase. Causes of disbelief in them are not only their continuing violations, nor distortions that stem from non-Western values. First and foremost, they involve an exaggerated conceptual extension of those rights, promoted by the post-modern cultural Left, as well as the endless repetition of today anachronistic forms of action and positions inherent to the existing international protection system. In order to recuperate human rights on a constructive direction it is necessary to return to the Universal Declaration, of 1948, to update Lua Nova, São Paulo, 86: 253-260, 2012 255 Resumos / Abstracts a discourse that was originally built against dictatorships, and to re-adapt the whole system to the situation of present democracies under threat.

  8. Defesa dos direitos humanos: sistemas regionais

    Directory of Open Access Journals (Sweden)

    Hélio Bicudo

    2003-04-01

    Full Text Available O texto discorre sobre a institucionalização dos sistemas de promoção dos Direitos Humanos, ao longo do século XX. Tomando a Declaração Universal dos Direitos do Homem, de 1948, como base e ponto de partida, o articulista aborda as três principais vertentes dos sistemas de promoção desses direitos: a européia, a americana e a africana. A evolução de cada uma delas descrita analógica e epistemologicamente, de forma a salientar singularidades sem perder de vista as influências recíprocas ou mesmo as determinantes próprias do contexto espaço-social. Para finalizar, o articulista destaca a importância do Tribunal Penal Internacional no estabelecimento de uma justiça ecumênica. Concomitantemente, alerta para o perigo contido na ameaça de os EUA não o ratificarem.The text underlines the institutional character acquired by the main systems to promote Human Rights in the twentieth century. Taking the Universal Human Rigths Declaration, of 1948, as the basis for analysis, the author brings up three different approaches to promote these rights: the European, the American and the African. The evolution of each of them is described using its procedure as a basic reference. Besides, an analogical analysis, brings to the fore singularities, without ignoring reciprocal influences dictated by particular contexts, though. The author stresses the importance of the International Penal Court, as a means to establish ecumenical justice. At the same time, he reminds the reader of the risks implicit in the possible non-ratification of the IPC by United States.

  9. Current outlook of ethics in research with human subjects Panorama atual da ética em pesquisa em seres humanos

    Directory of Open Access Journals (Sweden)

    Marystella Tomoe Takahashi

    2011-04-01

    Full Text Available In the last decades, medical care has been increasingly permeated by the concept of evidence-based-medicine, in which clinical research plays a crucial role in establishing diagnostic and treatment. Following the improvements in clinical research, we have a growing concern and understanding that some ethical issues must be respected when the subjects are human beings. Research with human subjects relies on the principles of autonomy, beneficence, no maleficence and justice. Ordinance 196/96 from the National Health Board adds to the Brazilian legislation such renowned bioethical principles. AIM: Discuss the main ethical aspects involved in research with human subjects. MATERIALS AND METHODS: Critical analysis of Ordinance 196/96 and related literature. CONCLUSION: Ordinance 196/96 rules research with human subjects; nevertheless, it requires more in-depth discussions regarding the informed consent, use of placebo, research with vulnerable populations and research in developing countries.Nas últimas décadas, a medicina tem sido cada vez mais permeada pelo conceito de medicina baseada em evidências, na qual a pesquisa clínica possui papel crucial no estabelecimento de diretrizes diagnósticas e terapêuticas. Com o avanço da pesquisa clínica, surgiu a preocupação e o entendimento que certos padrões éticos devam ser obedecidos quando o objeto de estudo é o ser humano. A pesquisa em seres humanos baseia-se nos princípios da autonomia, beneficência, não maleficência e justiça. A Resolução 196/96 do Conselho Nacional de Saúde incorpora à legislação brasileira tais princípios bioéticos consagrados. OBJETIVO: Discutir os principais aspectos éticos envolvidos na pesquisa em seres humanos. MATERIAL E MÉTODO: Análise crítica da Resolução 196/96 do CNS e literatura correlata. CONCLUSÃO: A Resolução 196/96 do Conselho Nacional de Saúde regulamenta a experimentação em seres humanos, no entanto necessita de discussões mais

  10. Anti-SEMA4D Monoclonal Antibody VX15/2503 With Nivolumab or Ipilimumab in Treating Patients With Stage III or IV Melanoma

    Science.gov (United States)

    2018-02-01

    Metastatic Melanoma; Stage III Cutaneous Melanoma AJCC v7; Stage IIIA Cutaneous Melanoma AJCC v7; Stage IIIB Cutaneous Melanoma AJCC v7; Stage IIIC Cutaneous Melanoma AJCC v7; Stage IV Cutaneous Melanoma AJCC v6 and v7

  11. O papel da ONU no conflito do Saara Ocidental

    Directory of Open Access Journals (Sweden)

    Geraldine Rosas Duarte

    2016-03-01

    Full Text Available Em abril de 2015 o mandato da MINURSO foi mais uma vez prorrogado, embora não haja indícios de que a questão sarauí esteja caminhando rumo à resolução. O artigo analisa o papel da ONU no conflito refletindo sobre os limitados avanços alcançados por meio da intervenção.

  12. La doble historia de El convidado de papel

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    Ceballos Viro, Álvaro

    2011-12-01

    Full Text Available This article sets out to question the textual history of El convidado de papel, a novel by Benjamín Jarnés. The differences between the two firsts editions of this novel, published in 1928 and 1935, are more complex than has hitherto been assumed. They also allow to reconstruct a different plot from the one that can be found in literary histories. In its original version, El convidado de papel was not only a peculiar Bildungsroman, but also a typical doppelgänger narrative. Therefore, it contained a dense web of intertextual references which Jarnés deliberately eliminated in the second edition of the novel. These intertextual references stimulate the search for new sources as well as the re-evaluation of the precise mode of influence attributed to familiar sources.La presente contribución comienza problematizando la historia textual de El convidado de papel, de Benjamín Jarnés. Las diferencias entre las dos primeras ediciones, que datan de 1928 y 1935, no sólo son más complejas de lo que hasta ahora se había creído, sino que además permiten reconstruir un argumento diferente de aquél tácitamente consensuado por la historiografía literaria. Sin dejar de ser una peculiar novela de formación, El convidado de papel era en su versión original una novela de doble en toda regla, lo que la abría a unas relaciones intertextuales que Jarnés eliminó conscientemente en la segunda edición. Tales relaciones permiten, por un lado, sugerir nuevas influencias (o modos de influencia en la narrativa jarnesiana y, por otro lado, profundizar en las deudas contraídas con autores cuyo ascendiente ya era conocido por la crítica.

  13. Periodismo y ciclismo. Perspectivas del papel organizador de la prensa

    Directory of Open Access Journals (Sweden)

    Juan Francisco de la Cruz Moreno

    2002-01-01

    Full Text Available El presente artículo versa sobre el papel que la prensa ha ejercido en la creación y organización de competiciones deportivas, especialmente dentro del ciclismo. Las principales carreras del calendario cuentan con un origen periodístico motivado fundamentalmente por intereses económicos y, en algunos casos, también políticos.

  14. Recent developments in nanomedicine for melanoma treatment.

    Science.gov (United States)

    Tang, Jian-Qin; Hou, Xiao-Yang; Yang, Chun-Sheng; Li, Ya-Xi; Xin, Yong; Guo, Wen-Wen; Wei, Zhi-Ping; Liu, Yan-Qun; Jiang, Guan

    2017-08-15

    Melanoma is a most aggressive skin cancer with limited therapeutic options and its incidence is increasing rapidly in recent years. The discovery and application of new targeted therapy agents have shown significant benefits. However, adverse side-effects and resistance to chemotherapy remain formidable challenges in the clinical treatment of malignant melanoma. Nanotherapeutics offers an important prospect of overcoming these drawbacks. The anti-tumoral applications of nanomedicine are varied, including those in chemotherapy, RNA interference, photothermal therapy, and photodynamic therapy. Furthermore, nanomedicine allows delivery of the effector structures into the tumor site via passive or active targeting, thereby allowing increased therapeutic specificity and reduced side effects. In this review, we summarize the latest developments in the application of nanocarrier-mediated targeted drug delivery to melanoma and nanomedicine-related clinical trials in melanoma treatment. We also discuss existing problems and opportunities for future developments, providing direction and new thoughts for further studies. © 2017 UICC.

  15. Pembrolizumab for Ipilimumab-Resistant Melanoma

    Science.gov (United States)

    KEYNOTE-002 was designed to test the safety and efficacy of two doses of pembrolizumab compared with chemotherapy in patients with ipilimumab-resistant melanoma; interim results show that pembrolizumab improves progression-free survival for these patients

  16. TCGA study of genetic drivers of melanoma

    Science.gov (United States)

    A comprehensive analysis of the genome of cutaneous melanoma has provided new insights into the roles of frequently mutated cancer genes and other genomic alterations that drive the development of this disease.

  17. Metastatic malignant subungal melanoma: Importance of FNAC

    Directory of Open Access Journals (Sweden)

    Radhika Punshi Nandwani

    2014-01-01

    Full Text Available Subungual melanoma is a rare type of skin cancer. It is an uncommon form of acral lentiginous melanoma. Approximately 85% of cases are misdiagnosed initially, and it is generally associated with a poor prognosis. Herein, we describe a case of metastatic subungal melanoma to the axillary lymph node in a 45-year-old male. Diagnosis of metastasis was made based on cytology, where the clinicians were guided to search for primary. This case report highlights the role of fine-needle aspiration cytology (FNAC in the diagnosis of this entity to draw the attention of the reader to the possible underreporting of melanoma because of a variant that evades diagnosis and our reluctance to think about its existence.

  18. Nivolumab-Based Treatments for Advanced Melanoma

    Science.gov (United States)

    A summary of results from an international, double-blind, randomized phase III trial testing the combination of nivolumab (Opdivo®) and ipilimumab (Yervoy®) against nivolumab alone and ipilimumab alone in patients with advanced melanoma.

  19. Subungual melanoma: Management in the modern era.

    Science.gov (United States)

    Reilly, D J; Aksakal, G; Gilmour, R F; Gyorki, D E; Chauhan, A; Webb, A; Henderson, M A

    2017-12-01

    Subungual melanoma is a rare subtype of cutaneous melanoma that arises from the structures of the nail apparatus. It presents most commonly in older patients and at an advanced stage. A retrospective review of all patients with subungual melanoma in a single institution over a 15-year period was performed. In total, 54 patients were included (26 males, average age 62.9 years), of which 28 cases involved the upper limb. Median tumour thickness was 4.5 mm. Eighteen patients had lymph node metastasis at diagnosis, including 11 of 36 patients with positive sentinel lymph node biopsy. Median survival was 4.6 years. Subungual melanoma has a poor prognosis that is strongly associated with presence of nodal disease at diagnosis. Sentinel lymph node biopsy should be considered to determine stage and prognosis. Copyright © 2017 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

  20. Direitos humanos na atualidade: um mundo em crise

    Directory of Open Access Journals (Sweden)

    Eduardo Gomes Biacchi

    2017-04-01

    Full Text Available Preocupante é a ascensão do populismo dentro dos Estados Democráticos de Direito, em uma clara afronta e violação aos direitos humanos. Direitos esses que foram arduamente construídos e conquistados pela humanidade ao longo de períodos históricos e tiveram como ápice o fim da Segunda Guerra Mundial e a construção do Sistema Global de Proteção por meio da Organização das Nações Unidas, no século XX. No século XXI, diferentemente do que imaginávamos, caminhamos para um cenário confuso e melancólico, ante as claras e manifestas violações aos direitos humanos por parte dos Estados. Não obstante a comunidade internacional questione a efetividade na tutela dos direitos humanos dentro da ONU, em virtude da inexistência de mecanismos institucionalizados para buscarem a responsabilização internacional do Estado contra graves violações aos direitos humanos, a exemplo do que ocorre dentro do Sistema Interamericano de Proteção aos Direitos Humanos, verificamos que, guardadas as devidas proporções e dentro dos limites de atuação que o próprio direito internacional impõe, a ONU procura atuar eficazmente. [continua

  1. A Case of Melanoma Associated Leukoderma

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    Özer Arıcan

    2010-06-01

    Full Text Available Melanoma associated leukoderma is a rare disease characterized by hypopigmented or depigmented macules, which are usualy localized at distant sites from the primary malignant melonoma. Immunologic response to abnormal melanocytes is thought to be responsible for the physiopathology of the disease. A 34-year- old male patient with a facially localized melanoma associated leukoderma is presented and the clinical features, pathogenesis, differential diagnosis, treatment and follow-up of the disease are discussed with the recent literature.

  2. Genital melanoma: prognosis factors and treatment modality.

    Science.gov (United States)

    Ferraioli, Domenico; Lamblin, Gery; Mathevet, Patrice; Hetu, Jessika; Berakdar, Isabelle; Beurrier, Frederic; Chopin, Nicolas

    2016-11-01

    Genital melanoma is a rare pathology. We present the experience of two comprehensive cancer centers in Lyon (France) in the management of genital melanoma in order to identify prognostic factors and optimal treatments. Between April 1992 and Mars 2014, 16 patients with a primary genital melanoma were referred to our department. Nine patients presented a vaginal melanoma, six vulvar melanomas and only one cervical melanoma. The median dimension of the lesion was 33.7 mm (5-100 mm). The AJCC stage ranged from IB to IIIC. 12 cases were the classic dark-blue flat melanoma and the other 4 cases were an atypical amelanotic tumor. Wide local surgery was performed in nine patients. A radical surgery was performed in six patients. In the large cervical melanoma, radiotherapy was performed as first-line treatment. In all the patients regional lymph node staging was performed. Adjuvant treatment was realized in nine patients. Two patients are alive without recurrence. Only one patient was lost to the first follow-up. The other 13 patients experienced a rapid recurrence. The median disease-free survival and the median overall survival were 11.8 months (2-49 m) and of 30.4 m (11-144 m), respectively. The disease-free survival and overall survival could be linked to a clinical presentation (Breslow thickness and morphology of lesion) associated to the early diagnosis. In our small series, the most important prognosis factor remains the tumor thickness. These rare lesions should be treated in experienced centers in order to improve their prognostic.

  3. Extracutaneous melanomas: a primer for the radiologist

    OpenAIRE

    Keraliya, Abhishek R.; Krajewski, Katherine M.; Braschi-Amirfarzan, Marta; Tirumani, Sree Harsha; Shinagare, Atul B.; Jagannathan, Jyothi P.; Ramaiya, Nikhil H.

    2015-01-01

    Objective: The purpose of this article is to provide a comprehensive review of the imaging features of extracutaneous melanomas. Conclusion: Extracutaneous melanomas are clinically and biologically distinct from their more common cutaneous counterpart with higher frequency of metastatic disease and poorer overall prognosis. Complete surgical excision is the treatment of choice whenever possible; systemic therapy in the form of conventional chemotherapeutic agents as well as novel targeted age...

  4. Vitamin D and melanoma incidence and mortality.

    Science.gov (United States)

    Berwick, Marianne; Erdei, Eszter O

    2013-01-01

    The role of vitamin D (25-OH-D, or 25-hydroxyvitamin D) and its potential confounders in relationship to melanoma risk and mortality is discussed. The paradox that ultraviolet radiation (UVR) exposure is the major environmental risk factor for melanoma etiology as well as a major source of vitamin D might be explained by viewing vitamin D levels as the result of a healthy lifestyle rather than a cause of health. © 2012 John Wiley & Sons A/S.

  5. Peptide-Targeted Radionuclide Therapy for Melanoma

    Science.gov (United States)

    Miao, Yubin; Quinn, Thomas P.

    2011-01-01

    Melanocortin-1 receptor (MC1-R) and melanin are two attractive melanoma-specific targets for peptide-targeted radionuclide therapy for melanoma. Radiolabeled peptides targeting MC1-R/melanin can selectively and specifically target cytotoxic radiation generated from therapeutic radionuclides to melanoma cells for cell killing, while sparing the normal tissues and organs. This review highlights the recent advances of peptide-targeted radionuclide therapy of melanoma targeting MC1R and melanin. The promising therapeutic efficacies of 188Re-(Arg11)CCMSH (188Re-[Cys3,4,10, d-Phe7, Arg11]-α-MSH3-13), 177Lu- and 212Pb-labeled DOTA-Re(Arg11)CCMSH (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-[ReO-(Cys3,4,10, d-Phe7, Arg11)]-α-MSH3-13) and 188Re-HYNIC-4B4 (188Re-hydrazinonicotinamide-Tyr-Glu-Arg-Lys-Phe-Trp-His-Gly-Arg-His) in preclinical melanoma-bearing models demonstrate an optimistic outlook for peptide-targeted radionuclide therapy for melanoma. Peptide-targeted radionuclide therapy for melanoma will likely contribute in an adjuvant setting, once the primary tumor has been surgically removed, to treat metastatic deposits and for treatment of end-stage disease. The lack of effective treatments for metastatic melanoma and end stage disease underscores the necessity to develop and implement new treatment strategies, such as peptide-targeted radionuclide therapy. PMID:18387816

  6. TERT promoter mutations in melanoma survival.

    Science.gov (United States)

    Nagore, Eduardo; Heidenreich, Barbara; Rachakonda, Sívaramakrishna; Garcia-Casado, Zaida; Requena, Celia; Soriano, Virtudes; Frank, Christoph; Traves, Victor; Quecedo, Esther; Sanjuan-Gimenez, Josefa; Hemminki, Kari; Landi, Maria Teresa; Kumar, Rajiv

    2016-07-01

    Despite advances in targeted therapies, the treatment of advanced melanoma remains an exercise in disease management, hence a need for biomarkers for identification of at-risk primary melanoma patients. In this study, we aimed to assess the prognostic value of TERT promoter mutations in primary melanomas. Tumors from 300 patients with stage I/II melanoma were sequenced for TERT promoter and BRAF/NRAS mutations. Cumulative curves were drawn for patients with and without mutations with progression-free and melanoma-specific survival as outcomes. Cox proportional hazard regression models were used to determine the effect of the mutations on survivals. Individually, presence of TERT promoter and BRAF/NRAS mutations associated with poor disease-free and melanoma-specific survival with modification of the effect by the rs2853669 polymorphism within the TERT promoter. Hazard ratio (HR) for simultaneous occurrence of TERT promoter and BRAF/NRAS mutations for disease-free survival was 2.3 (95% CI 1.2-4.4) and for melanoma-specific survival 5.8 (95% CI 1.9-18.3). The effect of the mutations on melanoma-specific survival in noncarriers of variant allele of the polymorphism was significant (HR 4.5, 95% CI 1.4-15.2) but could not be calculated for the carriers due to low number of events. The variant allele per se showed association with increased survival (HR 0.3, 95% CI 0.1-0.9). The data in this study provide preliminary evidence that TERT promoter mutations in combination with BRAF/NRAS mutations can be used to identify patients at risk of aggressive disease and the possibility of refinement of the classification with inclusion of the rs2853669 polymorphism within TERT promoter. © 2016 UICC.

  7. Verrucous-Keratotic Malignant Melanoma (VKMM

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    Nikolay Damianov

    2017-07-01

    Full Text Available We report a patient with a verrucous keratotic variant of melanoma visiting the policlinic of Medical Institute of Ministry of Interior (MVR-Sofia, Department of Dermatology and Dermatologic surgery, with a keratotic verrucous lesion, located on the right thigh, partially deeply pigmented at upper right quadrant. The lesion had appeared three years ago before her presentation in the policlinic, and it had gradually enlarged and become darker in the last twelve months. The surface of the lesion was covered with thick hyperkeratotic lobules. The histologic evaluation revealed verrucous melanoma with a tumour thickness of 3 mm and Clark Level IV and focal ulceration. The tumour was staged as stage IIB (T3bN0M0. Sentinel lymph node biopsy was planned. Verrucous-keratotic forms of malignant melanoma occur more commonly in women and favour the extremities, but may be found on any anatomic site. Seventy-one percent of this melanoma type are situated on the upper and lower extremities. Although two-thirds of these neoplasms can be can be histologically graded according to the classification of Clark, one-third of these melanomas with marked verrucous hyperplasia and hyperkeratosis of the epidermis do not fit into his classification. Histological classification of patients with a verrucous keratotic type of melanoma may sometimes be extremely difficult. The marked papilliferous architecture of these lesions made an assessment of Breslow depth difficult. The presented case highlights the clinical existence and features of such benign-looking melanomas. It is therefore important for surgical pathologists to recognise this unusual variant of malignant melanoma, as it may be confused both clinically and pathologically with benign lesions.

  8. Intratumoral Approaches for the Treatment of Melanoma.

    Science.gov (United States)

    Bommareddy, Praveen K; Silk, Ann W; Kaufman, Howard L

    There have been significant advances in the immunotherapy of melanoma over the last decade. The tumor microenvironment is now known to promote an immune-suppressive milieu that can block effective immune-mediated tumor rejection. Several novel strategies designed to overcome local immunosuppression hold promise for treatment of melanoma and other cancers. These approaches include oncolytic viruses, plasmid DNA delivery, Toll-like receptor agonists, inflammatory dyes, cytokines, checkpoint inhibitors, immunomodulatory agents, and host and pathogenic cell-based vectors. In addition, there are several novel methods for local drug delivery, including direct injection, image-guided, electroporation, and nanodelivery techniques under study. The approval of talimogene laherparepvec (Imlygic), an attenuated, recombinant oncolytic herpesvirus, for melanoma treatment is the first intratumoral agent to receive regulatory approval for the treatment of patients with melanoma. This review will focus on the rationale for intratumoral treatment in melanoma, describe the clinical and safety data for some of the agents in clinical development, and provide a perspective for future clinical investigation with intratumoral approaches. Melanoma has been a paradigm tumor for progress in targeted therapy and immunotherapy and will likely also be the tumor to establish the therapeutic role of intratumoral treatment for cancer.

  9. [Systemic treatment of inoperable metastasized malignant melanoma].

    Science.gov (United States)

    Gutzmer, R; Rauschenberg, R; Meier, F

    2016-07-01

    The medical therapy of inoperable malignant melanoma has changed dramatically over the last few years. The purpose of this article is to summarize the current state of systemic medical treatment of malignant melanoma. Clinical studies and guidelines in the therapy of malignant melanoma are reviewed. Medical therapy of inoperable melanoma changed due to developments in immunotherapies (checkpoint inhibitors) and molecular-targeted therapies (BRAF and MEK inhibitors). Checkpoint inhibitors are antibodies administered as infusions every 2-3 weeks, blocking the checkpoints PD-1 or CTLA-4, thus, preventing downregulation of the immune system. BRAF and MEK inhibitors are small molecules, they are given orally and block a certain signaling pathway in tumor cells. The activation of this pathway has to be demonstrated by molecular analysis of tumor tissue first. This strategy is currently registered for 40-50 % of melanomas harboring a BRAF V600 mutation, while the combination of a BRAF plus MEK inhibitor has been proven more efficient than a BRAF inhibitor alone. A fascinating development has started in the melanoma field due to immunotherapeutic and molecular-targeted treatment strategies. The continuation of this development needs further clinical and translational studies. This includes particular clinical studies with the new substances in the adjuvant situation, and sequences and combinations in the metastatic setting. Translational studies are needed to develop biomarkers for response and side effects.

  10. Cellular heterogeneity in vertical growth phase melanoma.

    Science.gov (United States)

    Laga, Alvaro C; Murphy, George F

    2010-12-01

    Melanoma growing as a tumorigenic nodule is one of the most virulent neoplasms to which the flesh is heir. At a considerably small tumor size, it incurs significant risk for widespread metastatic dissemination. There are no effective means of surgical intervention, chemical therapy, or immunologic therapy for advanced and metastatic melanoma. To review the literature and highlight recent cardinal advances in the understanding of melanoma vertical growth, with specific emphasis on how its recognition and characterization may be applied to diagnostic practice and development of novel investigative approaches. Literature review, archival material, personal experience, and research collaborators. The study of tumorigenic melanoma, both in primary lesions and in metastases, is the key to the eventual eradication of this highly virulent neoplasm that may disseminate widely when only occupying the volume of a grain of rice. Morphology often provides the first insight into structure and function. A growing database using meticulous and inclusive criteria to define tumor stem cells in the context of clinically relevant models now indicates that the key to melanoma heterogeneity may reside in a small subpopulation with the ability to self-renew and form tumors despite most cells present being significantly less virulent. Hopefully, from these insights into melanoma tumor progression from radial growth phase to heterogeneous and tumorigenic vertical growth phase will come additional answers to how smart therapies may be developed that specifically target those vertical growth phase cells that most pertain to patient survival.

  11. Targeting Sphingosine Kinase-1 To Inhibit Melanoma

    Science.gov (United States)

    Madhunapantula, SubbaRao V.; Hengst, Jeremy; Gowda, Raghavendra; Fox, Todd E.; Yun, Jong K; Robertson, Gavin P.

    2012-01-01

    SUMMARY Resistance to therapies develops rapidly for melanoma leading to more aggressive disease. Therefore, agents are needed that specifically inhibit proteins or pathways controlling the development of this disease, which can be combined, dependent on genes deregulated in a particular patient’s tumors. This study shows that elevated sphingosine-1-phosphate (S-1-P) levels resulting from increased activity of sphingosine kinase-1 (SPHK1) occur in advanced melanomas. Targeting SPHK1 using siRNA decreased anchorage dependent and independent growth as well as sensitized melanoma cells to apoptosis inducing agents. Pharmacological SPHK1 inhibitors SKI-I but not SKI-II decreased S-1-P content, elevated ceramide levels, caused a G2-M block and induced apoptotic cell death in melanomas. Targeting SPHK1 using siRNA or the pharmacological agent called SKI-I, decreased the levels of pAKT. Furthermore, SKI-I inhibited the expression of CYCLIN D1 protein and increased the activity of caspase-3/7, which in turn led to the degradation of PARP. In animals, SKI-I but not SKI-II retarded melanoma growth by 25-40%. Thus, targeting SPHK1 using siRNAs or SKI-I has therapeutic potential for melanoma treatment either alone or in combination with other targeted agents. PMID:22236408

  12. Melanoma m (zero): diagnosis and therapy.

    Science.gov (United States)

    Rastrelli, Marco; Alaibac, Mauro; Stramare, Roberto; Chiarion Sileni, Vanna; Montesco, Maria Cristina; Vecchiato, Antonella; Campana, Luca Giovanni; Rossi, Carlo Riccardo

    2013-01-01

    This paper reviews the epidemiology, diagnosis, and treatment of M zero cutaneous melanoma including the most recent developments. This review also examined the main risk factors for melanoma. Tumor thickness measured according to Breslow, mitotic rate, ulceration, and growth phase has the greatest predictive value for survival and metastasis. Wide excision of the primary tumor is the only potentially curative treatment for primary melanoma. The sentinel node biopsy must be performed on all patients who have a primary melanoma with a Breslow thickness > 1 mm, or if the melanoma is from 0,75 mm to 1 mm thick but it is ulcerated and/or the mitotic index is ≥1. Total lymph node dissection consists in removing the residual lymph nodes in patients with positive sentinel node biopsy, or found positive on needle aspiration biopsy, without radiological evidence of spread. Isolated limb perfusion and isolated limb infusion are employed in patients within transit metastases with a rate of complete remission in around 50% and 38% of cases. Electrochemotherapy is mainly indicated for palliation in cases of metastatic disease, though it may sometimes be useful to complete isolated limb perfusion. The only agent found to affect survival as an adjuvant treatment is interferon alpha-2. Adjuvant radiotherapy improves local control of melanoma in patients at a high risk of recurrence after lymph node dissection.

  13. Phytochemicals for the Management of Melanoma.

    Science.gov (United States)

    Pal, Harish Chandra; Hunt, Katherine Marchiony; Diamond, Ariana; Elmets, Craig A; Afaq, Farrukh

    2016-01-01

    Melanoma claims approximately 80% of skin cancer-related deaths. Its life-threatening nature is primarily due to a propensity to metastasize. The prognosis for melanoma patients with distal metastasis is bleak, with median survival of six months even with the latest available treatments. The most commonly mutated oncogenes in melanoma are BRAF and NRAS accounting approximately 60% and 20% of cases, respectively. In malignant melanoma, accumulating evidence suggests that multiple signaling pathways are constitutively activated and play an important role in cell proliferation, cell survival, epithelial to mesenchymal transition, metastasis and resistance to therapeutic regimens. Phytochemicals are gaining considerable attention because of their low toxicity, low cost, and public acceptance as dietary supplements. Cell culture and animals studies have elucidated several cellular and molecular mechanisms by which phytochemicals act in the prevention and treatment of metastatic melanoma. Several promising phytochemicals, such as, fisetin, epigallocatechin-3-gallate, resveratrol, curcumin, proanthocyanidins, silymarin, apigenin, capsaicin, genistein, indole-3-carbinol, and luteolin are gaining considerable attention and found in a variety of fresh fruits, vegetables, roots, and herbs. In this review, we will discuss the preventive potential, therapeutic effects, bioavailability and structure activity relationship of these selected phytochemicals for the management of melanoma.

  14. Treatment and outcomes of anorectal melanoma.

    LENUS (Irish Health Repository)

    Heeney, Anna

    2012-02-01

    INTRODUCTION: anorectal melanoma is an uncommon disease constituting less than 3% of all melanomas. Due to its rarity, there are a lack of randomized control trials regarding appropriate management and current evidence is based mainly on retrospective studies. METHODS: in view of the controversial surgical treatment of anorectal melanoma, we review the most published literature in an attempt to elucidate its typical clinical features along with current thinking with respect to management approaches to this aggressive disease. Using the keywords "anorectal" and "malignant melanoma", a medline search of all articles in English was performed and the relevant articles procured. Additional references were retrieved by cross reference from key articles. RESULTS: anorectal melanoma affects the elderly with a slight preponderance for females. It commonly presents disguised as benign disease with local bleeding or suspicion for haemorrhoidal disease. There is no convincing evidence to indicate that radical resection of primary anorectal melanoma is associated with improvement in local control or survival, and local excision is an acceptable treatment option. CONCLUSION: optimum management depends on several factors and the therapeutic goals should be to lengthen survival and preserve quality-of-life. Given that wide local excision is a more limited intervention with comparable survival it should be considered as the initial treatment choice. Unfortunately prognosis for patients with this disease remains poor despite choice of treatment strategy with overall five year disease-free survival less than twenty percent in most studies.

  15. Anorectal Malignant Melanomas: Experience of Uludag University

    Directory of Open Access Journals (Sweden)

    Berna Aytac

    2010-12-01

    Full Text Available Anorectal melanomas represent a group of mucosal melanomas with unknown etiology and poor prognosis. The lesions can be misdiagnosed as hemorrhoids during clinical examination. We reviewed the morphological and clinical features of 14 anorectal melanomas, and discuss the treatment modalities of this entity. Fourteen patients who were diagnosed with anorectal malignant melanoma between 1997 and 2004 were evaluated with regard to age, sex, size, morphology, lymph node or distant metastasis, treatment modality and survival. Eight patients were female and six were male, and their mean age was 58 years. The size of melanoma ranged from 3 cm to 8 cm. Pathological evaluation revealed epithelioid and spindle cell type tumor in seven and two patients, respectively, whereas, in the remaining seven patients, the tumor was composed of both types. Pigmentation was apparent in all tumors. There was lymph node metastasis in 11 patients and distant metastasis in all patients. Eleven patients underwent abdominoperineal resection and three were treated by local excision. Mean survival was 8.7 months. Prognosis of anorectal melanoma remains poor. Awareness of the diverse clinicopathological features of these lesions, both on the part of the clinicians and pathologists, is crucial for their early detection and proper treatment.

  16. Gestão de pessoas: de recursos humanos ao processo de desenvolvimento humano e social

    Directory of Open Access Journals (Sweden)

    Carla Cristina Dutra Búrigo

    2011-01-01

    Full Text Available Este ensaio teórico-empírico tem como objetivo possibilitar reflexões sobre o processo de constituição da área de Gestão de Pessoas no que tange a concepção de homem, de mundo e de sociedade, revelando a possibilidade de elevar o processo de gerenciamento de recursos humanos ao de desenvolvimento humano e social. Para tanto, situamos como realidade concreta para o estudo neste ensaio, a área de Gestão de Pessoas da Universidade Federal de Santa Catarina (UFSC, no que se refere a sua ação como unidade administrativa diante da política de desenvolvimento e do contexto no qual está inserida. A Pró-Reitoria de Desenvolvimento Humano e Social (PRDHS/UFSC é um órgão executivo da administração superior, criada com o objetivo de auxiliar o Reitor em suas tarefas na área de Gestão de Pessoas, com vistas à melhoria do nível de qualidade de vida no trabalho do servidor3, a sua potencialização como agente de transformação social e a humanização das relações de trabalho. Concebemos que a área de Gestão de Pessoas é um desafio lógico. É viver entre a utopia e a realidade cada vez mais estreita e sufocante, e das contradições e antagonismos do que é necessário fazer e o que verdadeiramente se faz diante da tônica do desenvolvimento.Abstract This theoretical and empirical essay aims to discuss the process of establishing the area of People Management in relation to conception of man, world and society, revealing the possibility of raising the process of managing the human resources to the human and social development. Therefore, we place as a concrete reality to study this essay, the area of PeopleManagement from the Federal University of Santa Catarina (UFSC, in relation to its action as an administrative unit on its development policy and the context in which it is inserted. The Pró-Reitoria de Desenvolvimento Humano e Social (PRDHS/UFSC is an executive body ofsenior management, created with the objective of

  17. Thigmotropism of Malignant Melanoma Cells

    Directory of Open Access Journals (Sweden)

    Pascale Quatresooz

    2012-01-01

    Full Text Available During malignant melanoma (MM progression including incipient metastasis, neoplastic cells follow some specific migration paths inside the skin. In particular, they progress along the dermoepidermal basement membrane, the hair follicles, the sweat gland apparatus, nerves, and the near perivascular space. These features evoke the thigmotropism phenomenon defined as a contact-sensing growth of cells. This process is likely connected to modulation in cell tensegrity (control of the cell shape. These specifically located paucicellular aggregates of MM cells do not appear to be involved in the tumorigenic growth phase, but rather they participate in the so-called “accretive” growth model. These MM cell collections are often part of the primary neoplasm, but they may, however, correspond to MM micrometastases and predict further local overt metastasis spread.

  18. Thigmotropism of malignant melanoma cells.

    Science.gov (United States)

    Quatresooz, Pascale; Piérard-Franchimont, Claudine; Noël, Fanchon; Piérard, Gérald E

    2012-01-01

    During malignant melanoma (MM) progression including incipient metastasis, neoplastic cells follow some specific migration paths inside the skin. In particular, they progress along the dermoepidermal basement membrane, the hair follicles, the sweat gland apparatus, nerves, and the near perivascular space. These features evoke the thigmotropism phenomenon defined as a contact-sensing growth of cells. This process is likely connected to modulation in cell tensegrity (control of the cell shape). These specifically located paucicellular aggregates of MM cells do not appear to be involved in the tumorigenic growth phase, but rather they participate in the so-called "accretive" growth model. These MM cell collections are often part of the primary neoplasm, but they may, however, correspond to MM micrometastases and predict further local overt metastasis spread.

  19. Ensino fundamental: papel do professor, motivação e estimulação no contexto escolar

    Directory of Open Access Journals (Sweden)

    Cynthia Bisinoto Evangelista de Oliveira

    2005-08-01

    Full Text Available Este trabalho apresenta dados de professores do Ensino Fundamental, analisando o entendimento do papel do professor no processo de estimulação e manutenção do interesse dos alunos pela escola. O referencial teórico adotado compreende o desenvolvimento humano pela interação social mediada, utilizando como instrumento um roteiro de entrevista semi-estruturado aplicado a cinco professoras, abordando temas da formação, concepções sobre "bons e maus alunos" e definições sobre estimulação e motivação. Os resultados, analisados em uma perspectiva qualitativa-descritiva, mostram concepções de bom aluno, valorizando aspectos da cultura escolar e a participação ativa dos alunos. Há a satisfação pela profissão, contudo, queixas da má remuneração e desvalorização no magistério. Não há descrição objetiva para os conceitos de motivação e estimulação. Percebe-se a necessidade de instrumentalizar estes docentes para atuarem como mediadores no processo de ensino-aprendizagem, buscando coerência nas concepções dos professores e dos alunos, evitando desinteresses, processos de fracasso e evasão escolar.

  20. El papel de la asertividad sexual en la sexualidad humana: una revisión sistemática

    Directory of Open Access Journals (Sweden)

    Pablo Santos-Iglesias

    2010-01-01

    Full Text Available El estudio de la asertividad sexual ha generado resultados que demuestran su importancia y su papel fundamental en la sexualidad humana. En este estudio teórico se lleva a cabo una revisión sistemática de los principales resultados obtenidos en estos estudios. Después de una búsqueda en las principales bases de datos se obtiene un total de 76 trabajos publicados entre 1980 y 2009, que demuestran que la asertividad sexual es un factor determinante tanto de la respuesta sexual como del funcionamiento sexual humano. Además se relaciona de forma directa con una visión positiva de la sexualidad humana y con algunas variables sociodemográficas como el sexo, aunque esta relación no está clara. Otros estudios ponen de manifiesto que es un factor de protección ante experiencias de abuso y victimización sexual, así como ante conductas sexuales de riesgo. Se discuten los resultados y se plantea la necesidad de incluir la asertividad sexual de forma específica, más que la asertividad general, en los programas educativos y en intervenciones con poblaciones en situación de riesgo.

  1. Solitary Secondary Malignant Melanoma of Clavicle Two Years after Enuclation for Ocular Melanoma

    Directory of Open Access Journals (Sweden)

    Halil Tozum

    2013-01-01

    Full Text Available Solitary metastasis of uveal melanoma to bone is extremely rare and usually associated with other organ involvement. We present a rare case of an ocular melanoma patient presenting with solitary metastasis to the clavicle two years after enucleation, without any other organ involvement. In this report, we tried to present our treatment strategy for the solitary metastasis of bone.

  2. Naturally occurring melanomas in dogs as models for non-UV pathways of human melanomas.

    Science.gov (United States)

    Gillard, Marc; Cadieu, Edouard; De Brito, Clotilde; Abadie, Jérôme; Vergier, Béatrice; Devauchelle, Patrick; Degorce, Frédérique; Dréano, Stephane; Primot, Aline; Dorso, Laetitia; Lagadic, Marie; Galibert, Francis; Hédan, Benoit; Galibert, Marie-Dominique; André, Catherine

    2014-01-01

    Spontaneously occurring melanomas are frequent in dogs. They appear at the same localizations as in humans, i.e. skin, mucosal sites, nail matrix and eyes. They display variable behaviors: tumors at oral localizations are more frequent and aggressive than at other anatomical sites. Interestingly, dog melanomas are associated with strong breed predispositions and overrepresentation of black-coated dogs. Epidemiological analysis of 2350 affected dogs showed that poodles are at high risk of developing oral melanoma, while schnauzers or Beauce shepherds mostly developped cutaneous melanoma. Clinical and histopathological analyses were performed on a cohort of 153 cases with a 4-yr follow-up. Histopathological characterization showed that most canine tumors are intradermal and homologous to human rare morphological melanomas types - 'nevocytoid type' and 'animal type'-. Tumor cDNA sequencing data, obtained from 95 dogs for six genes, relevant to human melanoma classification, detected somatic mutations in oral melanoma, in NRAS and PTEN genes, at human hotspot sites, but not in BRAF. Altogether, these findings support the relevance of the dog model for comparative oncology of melanomas, especially for the elucidation of non-UV induced pathways. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  3. Hereditary Melanoma: Update on Syndromes and Management - Genetics of familial atypical multiple mole melanoma syndrome

    Science.gov (United States)

    Soura, E.; Eliades, P.; Shannon, K.; Stratigos, A.; Tsao, H.

    2015-01-01

    Malignant melanoma is considered the most lethal skin cancer if not detected and treated at its early stages. About 10% of melanoma patients report a family history of melanoma; however, individuals with features of true hereditary melanoma (i.e. unilateral lineage, multi-generational, multiple primary lesions, and early onset of disease) are in fact quite rare. Although many new loci have been implicated in hereditary melanoma, CDKN2A mutations remain the most common. Familial melanoma in the presence of multiple atypical nevi should raise suspicion for a germline CDKN2A mutation. Such patients have a high risk of developing multiple primary melanomas and internal organ malignancies especially pancreatic cancer; thus, a multidisciplinary approach is necessary in many cases. The value of dermoscopy examination and total body photography performed at regular intervals has been suggested by a number of studies, and should therefore be considered for these patients and their first degree relatives. In addition, genetic counseling with the possibility of testing can be a valuable adjunct for familial melanoma patients. But, this must be performed with care and only by qualified individuals trained in cancer risk analysis. PMID:26892650

  4. Comprehensive histopathological comparison of epidermotropic/dermal metastatic melanoma and primary nodular melanoma.

    Science.gov (United States)

    Skala, Stephanie L; Arps, David P; Zhao, Lili; Cha, Kelly B; Wang, Min; Harms, Paul W; Andea, Aleodor A; Fullen, Douglas R; Chan, May P

    2018-02-01

    Metastatic melanoma involving the epidermis and/or upper dermis may show significant histological overlap with primary cutaneous melanoma, especially the nodular subtype. Proper histopathological classification is crucial to appropriate staging and management, but is often challenging. The aim of this study was to identify helpful histopathological features for differentiating epidermotropic/dermal metastatic melanoma (EDMM) and primary nodular melanoma (PNM). A cohort of EDMMs (n = 74) and PNMs (n = 75) was retrospectively reviewed for various histopathological features, and the data were compared between groups by the use of univariate analysis. Features significantly associated with EDMM included a tumour size of 10 mm, ulceration, epidermal collarettes, a higher mitotic rate, necrosis, multiple phenotypes, significant pleomorphism, and lichenoid inflammation. In multivariate analysis, a logistic regression model including large tumour size, ulceration, prominent TIPs, lichenoid inflammation and epidermal collarettes was highly predictive of PNM. Six (8%) EDMMs from three patients showed an 'epidermal-only' or 'epidermal-predominant' pattern closely simulating in-situ or microinvasive melanoma. Two of these cases were tested by fluorescence in-situ hybridisation, which confirmed clonal relationships with their corresponding primary melanomas. This is the first comprehensive histopathological comparison of EDMM and PNM. Recognition of the above histopathological associations should aid in the correct classification and staging of cutaneous melanoma. Epidermotropic metastatic melanomas may occasionally show an epidermal-only/epidermal-predominant pattern; accurate diagnosis requires prudent clinical correlation and, when necessary, ancillary molecular tests. © 2017 John Wiley & Sons Ltd.

  5. Fear of new or recurrent melanoma after treatment for localised melanoma.

    Science.gov (United States)

    Bell, Katy J L; Mehta, Yachna; Turner, Robin M; Morton, Rachael L; Dieng, Mbathio; Saw, Robyn; Guitera, Pascale; McCaffery, Kirsten; Low, Donald; Low, Cynthia; Jenkins, Marisa; Irwig, Les; Webster, Angela C

    2017-11-01

    To estimate the amount of fear of new or recurrent melanoma among people treated for localised melanoma in an Australian specialist centre. We randomly selected 400 potential participants from all those treated for localised melanoma at the Melanoma Institute Australia during 2014 (n = 902). They were asked to complete an adapted version of the Fear of Cancer Recurrence Inventory (FCRI). We calculated summary statistics for demographics, clinical variables and total FCRI and subscale scores. Two hundred fifteen people (54%) completed the FCRI questionnaire. The overall mean severity subscale score was 15.0 (95% CI 14.0-16.1). A high proportion of participants had scores above a proposed threshold to screen for clinical fear of cancer recurrence (77% and 63% of participants with and without new or recurrent melanoma had severity subscale scores ≥13). Most participants also had scores above a threshold found to have high specificity for clinical fear of cancer recurrence (65% and 48% of participants with and without new or recurrent melanoma had severity subscale scores ≥16). The severity subscale appeared to discriminate well between groups with differing levels of risk of new or recurrent melanoma. There is a substantial amount of fear of new or recurrent melanoma among this population, despite most having a very good prognosis. Copyright © 2017 John Wiley & Sons, Ltd.

  6. Proteção internacional dos direitos humanos

    Directory of Open Access Journals (Sweden)

    Amanda Thereza Lenci Paccola

    2017-11-01

    Full Text Available Podemos observar no presente trabalho de pesquisa, desde as bases dos Direitos Humanos, suas influências e surgimento. Esta pesquisa tende a expor como funcionam seus mecanismos e quais são os seus procedimentos, com grande enfoque na atuação da Organização das Nações Unidas (ONU. Os direitos humanos muitas vezes, apesar de protegidos por tratados internacionais não são respeitados. Assim, nesta abordagem, veremos os principais pactos/tratados/convenções sobre o tema, e como proposito final será feita uma análise de como a diplomacia e o governo brasileiro se comportam em relação à proteção do instituto de direitos humanos, juntamente com a importância dada a ele atualmente em sua política externa.

  7. OPTIMIZACIÓN DEL CAPITAL HUMANO VERSUS DESEMPLEO

    Directory of Open Access Journals (Sweden)

    Armando Cuesta Santos

    2003-12-01

    Full Text Available

    Es argumentada la necesidad de trascender los paradigmas de considerar al trabajador como un costo y también de concebirlo como una inversión de la empresa, asumiendo el paradigma de considerarlo como inversión de su propio capital humano. En consecuencia, el enfoque reductor de personal con el consiguiente desempleo en aras del incremento de la productividad del trabajo, deberá ser superado por el enfoque de optimización del capital humano en la organización. El objetivo de este trabajo es contribuir a esa optimización al ir asumiendo el paradigma del trabajador como inversor de su capital humano, en oposición al desempleo implicado por el paradigma predominante concibiendo al trabajador como un costo.

  8. El Bocavirus humano: un nuevo virus respiratorio Human bocavirus: a new respiratory virus

    Directory of Open Access Journals (Sweden)

    Carlos Aguirre Muñoz

    2006-01-01

    Full Text Available Las infecciones respiratorias agudas son una causa muy importante de morbilidad y mortalidad, especialmente en los niños y en los países en desarrollo. Con los métodos de laboratorio actuales, aproximadamente una tercera parte de estas infecciones se queda sin diagnóstico etiológico. Se acepta que los virus juegan un papel cardinal y que más de 200 virus, pertenecientes a seis familias virales están implicados en la génesis de este problema. La familia Parvoviridae se conoce desde mediados del siglo XX. El Parvovirus humano B19, identificado en 1980 y causante de enfermedades febriles y exantemáticas, fue considerado por muchos años como el único miembro de esta familia capaz de afectar a la especie humana. Sin embargo, un grupo de investigadores suecos comandado por Tobías Allander informó en agosto de 2005 el hallazgo de un nuevo Parvovirus, denominado provisionalmente Bocavirus humano, relacionado con infección respiratoria aguda en niños. En este artículo se resumen las características de este nuevo agente, se resalta la importancia de su hallazgo y de la técnica de investigación empleada. Respiratory tract infections are a leading cause of morbidity and mortality, mainly in children and also in developing countries. The aethiology of approximately 30% of these infections remains obscure, using current laboratory methods. It has been accepted that viruses play an important role and more than 200 viruses, belonging to 6 viral families are implied in the pathogenesis of this problem. Parvoviridae family has been known since the middle of the XX century. Human Parvovirus B19 was identified in 1980; it causes rashes and febrile diseases and it was considered for many years as the only member of this family able to affect humans. However, Dr. Tobias Allander and colleagues, at Karolinska Institut, have discovered a previously unknown parvovirus, called Human Bocavirus, that has been found to affect children, causing lower

  9. Melanoma

    Science.gov (United States)

    ... Registration General information Housing & travel Education Exhibit hall Mobile app 2019 Annual Meeting Derm Exam Prep Course ... SkinPAC State societies Scope of practice Truth in advertising NP/PA laws Action center Public and patients ...

  10. Las Remesas Internacionales y su incidencia en el Desarrollo Humano en San José Chiltepec, Oaxaca: Un estudio exploratorio

    Directory of Open Access Journals (Sweden)

    Beatriz Acosta Uribe

    2009-01-01

    Full Text Available Los estudios migratorios han focalizado una buena parte de su interés en las remesas y su posible impacto en las comunidades receptoras. La literatura especializada ha señalado y tipificado los rasgos esenciales del fenómeno, así como la importancia que tienen éstas en el desarrollo económico de México, fundamentalmente a partir de la dimensión regional. Sin embargo, poco se sabe sobre la relación entre las remesas y el Desarrollo Humano en los lugares de alta y mediana intensidad migratoria. Hoy en día existe un consenso en los trabajos de investigación sobre remesas en el sentido de que éstas se han constituido en un importante factor para incrementar los niveles de consumo y la adquisición de bienes duraderos por parte de los familiares de los migrantes (Canales, 2006. No obstante, es imperativo explorar y medir la potencial incidencia de las remesas en el mejoramiento de la calidad de vida de las personas que las reciben. En este sentido, el Programa de Naciones Unidas para el Desarrollo (PNUD ha definido el Desarrollo Humano como el proceso de ampliación de las capacidades para elegir de los individuos, y cuyo objetivo es expandir la gama de oportunidades para que las personas puedan vivir una vida saludable, creativa y con los recursos para desenvolverse adecuadamente en su entorno social (PNUD; 2009. El presente trabajo retoma tal perspectiva y examina el papel que desempeñan las remesas en el Desarrollo Humano en San José Chiltepec, Oaxaca, localidad enclavada en la cuenca alta del río Papaloapan y de reciente incorporación al fenómeno migratorio. Se analizó la variable de remesas del "Cuestionario de Salud de los Migrantes y sus Familias de la Región Papaloapan, aplicado en los meses de octubre-diciembre de 2008 en la cabecera municipal (Acosta, Ruiz, Flores, Martínez y Padilla, 2008. Se exploraron aspectos relativos a la dimensión del Desarrollo Humano en relación al uso que dan los familiares de los migrantes a

  11. Jurisprudencia de la Corte Interamericana de Derechos Humanos

    OpenAIRE

    Salmón, Elizabeth

    2011-01-01

    La valiosa Jurisprudencia de la Corte Interamericana de Derecho. Humanos no agota sus efectos en sus beneficiarios directos sino que también favorece al conjunto de la población de lo: estados sometidos a su jurisdicción al precisar el sentido contenido y alcances de los derechos. Esta función preventiva según se demuestra en esta publicación, constituye una finalidad esencial de todo sistema internacional de protección de derechos humanos. En este libro se identifica y analiza algunos de los...

  12. Sentencia sobre Reparación Integral de Derechos Humanos

    OpenAIRE

    Ecuador. Consejo de la Judicatura

    2014-01-01

    El Programa Andino de Derechos Humanos publica a continuación la sentencia emitida por un Juez de Tránsito en la que se determina la reparación integral para los familiares de una persona muerta a causa de un accidente de tránsito. Constituye un precedente importante en especial por la aplicación de estándares internacionales sobre la reparación integral de derechos humanos en cumplimiento con la normativa internacional.

  13. Derechos Humanos y Políticas Públicas. Manual

    OpenAIRE

    Deluchey, Jean-François Y.; Alza Barco, Carlos; Urueña, René; Montoya Céspedes, Nicolás; Estupiñan Silva, Rosmerlin; Fernández Gómez, Itziar; Sánchez Mojica, Beatriz Eugenia; Gavazzo, Natalia; Aguiar de Luque, Luis; Alencar Mayer Feitosa, María Luiza; Bregaglio, Renata; Urueña, René; Sánchez, Beatriz Eugenia; Anzola, Sergio; Salmón, Elizabeth

    2014-01-01

    El presente manual, el tercero y último elaborado en el marco de la Red Derechos Humanos y Educación Superior, tiene por objetivo ilustrar las relaciones que se establecen entre los derechos humanos y las políticas públicas. Se trata de un vínculo bastante más complejo de lo que a primera vista podría parecer. En efecto, los primeros no sólo son objeto de las segundas, como estrategia para alcanzar su garantía. También se han convertido en elementos centrales en el diseño...

  14. Grupo de sala de espera: sentidos do envelhecimento humano

    OpenAIRE

    Cesar Sandoval Moreira Jr.; Marisa Japur

    2003-01-01

    Este trabalho parte da consideração do envelhecimento humano como experiência heterogênea. Busca pôr em diálogo o grupo de sala de espera, recorrendo ao construcionismo social, para descrevê-lo como prática discursiva. Problematizando essa modalidade de intervenção psicológica, nesse estudo objetivamos descrever o processo de produção de sentidos sobre o envelhecimento humano nesse contexto. Dez grupos de sala de espera, gravados e transcritos, foram pré-analisados favorecendo a escolha de um...

  15. Competencias laborales de los gerentes de talento humano

    OpenAIRE

    Gregorio Calderón Hernández; Julia Clemencia Naranjo Valencia

    2004-01-01

    El reconocimiento de la importancia de las personas en el desarrollo de las organizaciones, especialmente por la posibilidad de construir ventaja competitiva fundamentada en el talento humano, está demandando de quienes lideran el área de recursos humanos el desarrollo de competencias que respondan a los nuevos retos. La revisión de investigaciones realizadas sobre el tema en otras latitudes permite concluir que existen diferentes tipologías de competencias para los profesionales del área de ...

  16. Selección de Recursos Humanos por Competencias

    OpenAIRE

    Sánchez Domingo, Cristina

    2013-01-01

    Los objetivos de este trabajo son, por un lado conocer en qué consisten los procesos de valoración y selección de personas desde el enfoque de las competencias laborales. Para ello, ha sido preciso profundizar en el estudio del concepto de “competencia laboral”, y comprender qué es la Gestión de Recursos Humanos por Competencias, en cuyo seno se encuentra la propia Selección de Recursos Humanos. Por otra parte, un segundo objetivo del trabajo es conocer el grado de implantación de la Selecció...

  17. Parasitismo de Amblyomma fuscum (Acari: Ixodidae) em humanos

    OpenAIRE

    Marques Sandro; Dal Col Rogério; Matos Júnior Marco Otávio de; Gonçalves Elisabeth Fernandes Bertoletti; Pinter Adriano; Labruna Marcelo Bahia

    2006-01-01

    Amblyomma fuscum é uma espécie rara de carrapato, recentemente revalidada, com poucos registros de ocorrência na literatura. Neste trabalho, são informados dois registros de parasitismo de A. fuscum em seres humanos: um no Estado de São Paulo (SP) e outro possivelmente oriundo do Estado de Santa Catarina (SC), Brasil. Tratam-se dos primeiros registros de parasitismo em humano por esta espécie de carrapato. Um espécime adulto fêmea de A. fuscum foi coletado quando encontrava-se fixado à palma ...

  18. Microbioma humano: implicações biomédicas

    OpenAIRE

    Correia, Filipe André Saraiva

    2015-01-01

    Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz O microbioma humano é o conjunto dos microrganismos presentes no organismo, sendo estes microrganismos caracterizados através da análise qualitativa do seu genoma. O desenvolvimento de técnicas analíticas inovadoras permitiu a identificação e compreensão das funções do microbioma humano. Este desempenha importantes funções metabólicas e influencia o funcionamento do sistema imunitário. O micro...

  19. DIREITOS HUMANOS, DESENVOLVIMENTO SUSTENTÁVEL E SUSTENTABILIDADE

    OpenAIRE

    Carvalho, Sonia Aparecida de; Silva, Denival Francisco da; Adolfo, Luiz Gonzaga Silva

    2015-01-01

    Este artigo trata da relação intrínseca entre os direitos humanos, o desenvolvimento sustentável e a sustentabilidade. Seu objetivo geral consiste em analisar o modelo de desenvolvimento implementado e a necessária proteção e preservação do meio ambiente ligado à defesa dos direitos humanos. Os objetivos específicos pretendem investigar a distinção dos termos sustentabilidade e desenvolvimento sustentável, como a concretização do direito à sustentabilidade, os critérios e as dimensões da sust...

  20. Jurisprudencia social del Tribunal Europeo de Derechos Humanos

    OpenAIRE

    Martínez Miranda, Macarena

    2016-01-01

    El presente artículo pretende reflexionar sobre la incidencia de la Jurisprudenciadel Tribunal Europeo de Derechos Humanos en el ámbito laboral, particularmenteen materia de derechos fundamentales, como canon hermenéutico de indudablevalor, al formar un cuerpo de doctrina relativa al Convenio Europeo de DerechosHumanos, así como a otros instrumentos emanados de órganos del Consejo deEuropa; con especial énfasis en determinados pronunciamientos, sin ánimoexhaustivo, tanto en el ámbito de propi...

  1. Melanoma risk perception and prevention behavior among African-Americans: the minority melanoma paradox

    Directory of Open Access Journals (Sweden)

    Goldenberg A

    2015-08-01

    Full Text Available Alina Goldenberg,1 Igor Vujic,2,3 Martina Sanlorenzo,2,4 Susana Ortiz-Urda2 1Department of Internal Medicine/Dermatology, University of California, San Diego, 2Mt Zion Cancer Research Center, University of California San Francisco, San Francisco, CA, USA; 3Department of Dermatology, The Rudolfstiftung Hospital, Academic Teaching Hospital, Medical University Vienna, Vienna, Austria; 4Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy Introduction: Melanoma is the most deadly type of skin cancer with 75% of all skin cancer deaths within the US attributed to it. Risk factors for melanoma include ultraviolet exposure, genetic predisposition, and phenotypic characteristics (eg, fair skin and blond hair. Whites have a 27-fold higher incidence of melanoma than African-Americans (AA, but the 5-year survival is 17.8% lower for AA than Whites. It is reported continuously that AA have more advanced melanomas at diagnosis, and overall lower survival rates. This minority melanoma paradox is not well understood or studied. Objective: To explore further, the possible explanations for the difference in melanoma severity and survival in AA within the US. Methods: Qualitative review of the literature. Results: Lack of minority-targeted public education campaigns, low self-risk perception, low self-skin examinations, intrinsic virulence, vitamin D differences, and physician mistrust may play a role in the melanoma survival disparity among AA. Conclusion: Increases in public awareness of melanoma risk among AA through physician and media-guided education, higher index of suspicion among individuals and physicians, and policy changes can help to improve early detection and close the melanoma disparity gap in the future. Keywords: acral, advanced, African-American, disparity, melanoma, survival

  2. Nail apparatus melanoma: a diagnostic opportunity Melanoma do aparelho ungueal: uma oportunidade diagnóstica

    Directory of Open Access Journals (Sweden)

    Ana Maria Carreño

    2013-04-01

    Full Text Available Malignant Melanoma is a high mortality neoplasm. The involvement of the nail apparatus is rare, with only 2 out of 3 patients seeking medical attention as the result of recent nail melanocytic lesions. This results in late diagnosis and a prognosis worse than cutaneous melanoma. We report a female, presenting with ulcerative lesions with clinical and laboratory features compatible with leishmaniasis. On return after treatment initiation a longitudinal melanonychia was observed on her first right finger. Biopsy of the nail matrix was performed. Histopathology was compatible with melanoma in situ. Longitudinal melanonychia is not a specific sign for melanoma and it is important that the dermatologist should identify the suspect lesions correctly. The incidental diagnosis of nail melanoma in situ in our case significantly impacted the patient's survival.Melanoma Maligno é uma neoplasia de alta mortalidade, sendo raro o acometimento do aparelho ungueal. Apenas 2/3 dos pacientes procuram atendimento médico devido lesão melanocítica ungueal recente, tornando o diagnóstico tardio e com prognóstico pior que do melanoma cutâneo. Descreve-se um caso de paciente sexo feminino, apresentando lesões ulceradas com características clínico-laboratoriais compatíveis com leishmaniose tegumentar americana. No retorno após início do tratamento foi observada melanoníquia longitudinal no primeiro quirodáctilo direito. Realizada biópsia da matriz ungueal com histopatológico compatível com melanoma in situ. Melanoníquia longitudinal não é sinal específico de melanoma. A identificação das lesões suspeitas é importante tarefa dos dermatologistas. O diagnóstico incidental de melanoma ungueal in situ do caso relatado resultou em grande impacto na sobrevida da paciente.

  3. Common Moles, Atypical Moles (Dysplastic Nevi), and Risk of Melanoma

    Science.gov (United States)

    ... Melanoma—Patient Version Moles, Dysplastic Nevi, and Melanoma Recognition Tool Skin Cancer (Including Melanoma)—Patient Version What ... government may be owned by the writer, and graphics may be owned by their creator. In such ...

  4. Screening for metastatic malignant melanoma of the uvea revisited

    DEFF Research Database (Denmark)

    Eskelin, Sebastian; Pyrhönen, Seppo; Summanen, Paula

    1999-01-01

    ophthalmology, malignant uveal melanoma, metastasis, liver, screening, ultrasonography, X-ray, lactate dehydrogenase, alkaline phosphatase, aminotransferases......ophthalmology, malignant uveal melanoma, metastasis, liver, screening, ultrasonography, X-ray, lactate dehydrogenase, alkaline phosphatase, aminotransferases...

  5. LOS EXILIADOS. LA LUCHA POR LOS DERECHOS HUMANOS DURANTE LA DICTADURA, de Silvina Jensen

    Directory of Open Access Journals (Sweden)

    Nicolás Hochman

    2010-04-01

    Full Text Available RESEÑASLOS EXILIADOS. LA LUCHA POR LOSDERECHOS HUMANOS DURANTE LA DICTADURAJENSEN, Silvina (2009. Los exiliados. La lucha por losderechos humanos durante la dictadura , Buenos Aires:Sudamericana. ISSN 978-950-073-158-4

  6. Historia del currículum: Perspectivas y dilemas en la integración del desarrollo humano y en los textos escolares

    Directory of Open Access Journals (Sweden)

    Roberto Figueroa Molina

    2015-10-01

    Full Text Available En este trabajo se realiza un breve análisis del estudio del currículum como parte de la discusión historiográfica. Se plantean algunos argumentos para la consolidar una estructura curricular orientada hacía el desarrollo humano integral y se describe el papel que han logrado consolidar los textos escolares como parte de los contenidos en la organización curricular. AbstractIn this work, we make a brief análisis of the curriculum study as part of the historiographic discussions. Several arguments are established to consolidate a curricular structure towards the integral human development, and is described the role scholar textbooks have consolidated as part of the contents in the curricular organization.

  7. Palabra de abundancia: saberes indígenas que fortalecen diálogos interculturales de derechos humanos en la Amazonia colombiana

    Directory of Open Access Journals (Sweden)

    Alvaro Diego Herrera Arango

    2016-03-01

    Full Text Available Este artículo analiza el papel de los saberes indígenas de la Gente de Centro −grupo indígena multiétnico de la Amazonia colombiana− en el Plan de salvaguarda étnico uitoto capítulo Leticia (PSE. Este es uno de los 34 planes que el Estado colombiano, obligado por la Corte Constitucional, ha formulado e implementado para proteger a los pueblos indígenas amenazados por el desplazamiento forzado. Con base en la investigación anticolonial y de la descolonización, y en la perspectiva subalterna de los derechos humanos, se analiza el PSE como un diálogo intercultural inequitativo en el que los pueblos indígenas son obligados a expresarse según los discursos de derechos del Estado y de la Corte.

  8. Role of radiotherapy in melanoma management

    International Nuclear Information System (INIS)

    Strojan, Primoz

    2010-01-01

    In melanoma, radiotherapy has generally been considered as a palliative treatment option indicated only for advanced cases or disseminated disease. In the 70s of the previous century, the technological advances in radiotherapy, linked to rapid development of computer sciences, resulted in restored interest for radiotherapy in melanoma management. Although a fundamental lack of well designed prospective and/or randomized clinical trials critically influenced the integration of radiotherapy into treatment strategies in melanoma, radiotherapy was recently recognized as an indispensable part in the multidisciplinary management of patients with melanoma. Altogether, approximately 23% of melanoma patients should receive at least one course of radiotherapy during the course of the disease. In this review, radiobiological properties of melanoma that govern the decisions for the fractionation patterns used in the treatment of this disease are described. Moreover, the indications for irradiation and the results of pertinent clinical studies from the literature, creating a rationale for the use of radiotherapy in the management of this disease, are reviewed and a brief description of radiotherapy techniques is given. Basic treatment modality in melanoma is surgery. However, whenever surgery is not radical or there are adverse prognostic factors identified on histopathological examination of resected tissue specimen, it needs to be supplemented. Also, in patients with unresectable disease or in those not being suitable for major surgery or who refuse proposed surgical intervention, other effective mode(s) of therapy need to be implemented. From this perspective, supported by clinical experiences and literature results, radiotherapy is a valuable option: it is effective and safe, in curative and palliative setting

  9. Melanoma Exosomes Enable Tumor Tolerance in Lymph Nodes

    OpenAIRE

    Hood, Joshua L.

    2016-01-01

    Melanoma preferentially spreads via lymph nodes. Melanoma exosomes can induce angiogenesis and immune suppression. However, a role for melanoma exosomes in facilitating tumor tolerance in lymph nodes has not been considered. Herein, the hypothesis that melanoma exosome mediated induction of vascular endothelial cell (VEC) derived TNF-α results in lymphatic endothelial cell (LEC) mediated tumor tolerance is explored. To support this hypothesis, experiments involving ex vivo lymph node associat...

  10. Long-term Survival after Metastatic Childhood Melanoma

    DEFF Research Database (Denmark)

    Larsen, Anne Kristine; Bybjerg Jensen, Mette; Krag, Christen

    2014-01-01

    SUMMARY: Malignant melanoma in children is very rare and accounts for only 1-3% of all melanomas. A congenital melanocytic nevus depending on the size of the lesion is one of the risk factors for developing childhood melanoma because of the possible malignant transformation. Childhood malignant m...... survived 26 years without recurrence, thus representing an uplifting case of long-term survival of childhood melanoma....

  11. A new understanding in the epidemiology of melanoma

    OpenAIRE

    Erdei, Esther; Torres, Salina M

    2010-01-01

    The incidence of melanoma is continuing to increase worldwide. UV exposure is a known risk factor for melanoma. Geographic location is known to influence UV exposure and the distribution of the incidence of melanoma. Furthermore, epidemiologic data suggest that gender and genetics may influence the distribution of melanoma on the body surface and histopathologic characteristics of the lesion. This article describes what is known about the impact of gender, ethnicity and geography on the progr...

  12. Subretinal lipid exudation associated with untreated choroidal melanoma

    Directory of Open Access Journals (Sweden)

    C K Minija

    2011-01-01

    Full Text Available Subretinal lipid exudation in an untreated choroidal melanoma is very rare. It is seen following plaque radiotherapy in choroidal melanoma. There is only one case report of untreated choroidal melanoma with massive lipid exudation in a patient with metastatic hypernephroma. We report here a rare case of untreated choroidal melanoma with lipid exudation. Subretinal exudation that is rarely seen following plaque brachytherapy was noted at the borders of this untreated tumor. Lipid exudation partially resolved following brachytherapy.

  13. Metastatic Malignant Melanoma Presenting as an Appendiceal Mucocele

    Directory of Open Access Journals (Sweden)

    A. A. Alduaij

    2011-01-01

    Full Text Available Melanoma metastatic to the appendix is extremely rare. Here we describe a case of a 31-year-old female from Bolivia with a remote history of metastatic malignant melanoma first diagnosed as a cutaneous malignant melanoma ten years prior to this presentation. The patient was being followed for a mucocele which on resection was found to be metastatic melanoma. “Mucocele” is a generic diagnosis that warrants further characterization and treatment.

  14. El coleccionismo: el rescate de las cosas y lo humano = Colecionismo: o resgate das coisas e do humano

    Directory of Open Access Journals (Sweden)

    Valis, Noël

    2013-01-01

    Full Text Available Proposta de uma reflexão aprofundada sobre o ato de colecionar, uma das pulsões menos compreendidas pelo pensamento contemporâneo, aqui concebido como uma extensão humanizadora do Ser. O destino dos objetos é o nosso destino, porque sem eles não existiríamos como seres verdadeiramente humanos. O artigo se apóia em teóricos como Walter Benjamin ou Hannah Arendt e se detêm em romancistas que têm refletido sobre o colecionismo em suas distopias, em que o ser humano é tratado como um objeto

  15. CASE REPORT Metastatic melanoma to the small bowel ...

    African Journals Online (AJOL)

    lymphoma; however, a high index of suspicion for metastatic melanoma should be maintained if the patient presents with seemingly unrelated symptoms or history of treated melanoma in the past. 1. Casanova F, Lizazo J, Shezi S, Oliver F. Right inguinal bowel fistula on the course of melanoma disease. Internet Journal of ...

  16. Oral Malignant Melanoma in a Ferret ( Mustela putorius furo).

    Science.gov (United States)

    d'Ovidio, Dario; Rossi, Giacomo; Meomartino, Leonardo

    2016-06-01

    Oral malignant melanomas are one of the most common oral malignant neoplasms in dogs but are rare in other domesticated species. This case report describes the clinical manifestations and histological appearance of oral melanoma in a ferret ( Mustela putorius furo). To the authors' knowledge, this is the first published description of a clinical case and histopathological findings of oral melanoma in this species.

  17. Single institution experience of paediatric melanoma in Victoria, Australia.

    Science.gov (United States)

    Le, Quynh; Norris, Diana; McClean, Catriona A; Mcguiness, Myra; Meani, Rowena; Kelly, John W; Pan, Yan

    2017-05-01

    Paediatric melanoma is an uncommon presentation of melanoma that accounts for 3% of all paediatric cancers. The objective was to describe a series of paediatric melanoma cases presenting to a state-wide tertiary referral service over the past 19 years. A search of the Victorian Melanoma Service database was performed to identify all patients under the age of 20 years diagnosed with melanoma from 1994 to 2013. Histological, demographic and phenotypical information for each patient was collected. Patients were matched against the Victorian Death Registry to identify those who had died. Fisher's exact test was used to examine associations. Melanoma-specific survival was estimated using the Kaplan-Meier method. A total of 65 paediatric melanoma patients were included for analysis, in whom 72.3% of melanomas were diagnosed when they were 16-19 years of age with a mean age at diagnosis of 16 years. The mean Breslow thickness was 1.4 mm. It was greatest (3.4 mm) in the youngest age group (melanoma-specific survival rate was 96.8%. This is the first descriptive epidemiological study of paediatric melanoma in Victoria. Further large, population-based, multi-institutional studies of paediatric melanoma are warranted to provide a clearer understanding of this group of melanoma patients. © 2016 The Australasian College of Dermatologists.

  18. Acral lentiginous melanoma in a pregnant African albino, atypical ...

    African Journals Online (AJOL)

    melanocytes). Acral lentiginous melanoma (ALM) is a kind of lentiginous skin melanoma. It is commonly observed on the palms, soles, under the nails and in mucous membranes. Unlike other forms of melanoma, ALM does not appear to be linked ...

  19. Cytotoxic T lymphocyte responses against melanocytes and melanoma

    Directory of Open Access Journals (Sweden)

    Schwartz Erich J

    2011-07-01

    Full Text Available Abstract Background Vitiligo is a common toxicity associated with immunotherapy for melanoma. Cytotoxic T lymphocytes (CTLs against melanoma commonly target melanoma-associated antigens (MAAs which are also expressed by melanocytes. To uncouple vitiligo from melanoma destruction, it is important to understand if CTLs can respond against melanoma and melanocytes at different levels. Methods To understand the dichotomous role of MAA-specific CTL, we characterized the functional reactivities of established CTL clones directed to MAAs against melanoma and melanocyte cell lines. Results CTL clones generated from melanoma patients were capable of eliciting MHC-restricted, MAA-specific lysis against melanocyte cell lines as well as melanoma cells. Among the tested HLA-A*0201-restricted CTL clones, melanocytes evoked equal to slightly higher degranulation and cytolytic responses as compared to melanoma cells. Moreover, MAA-specific T cells from vaccinated patients responded directly ex vivo to melanoma and melanocytes. Melanoma cells express slightly higher levels of MART-1 and gp100 than melanocytes as measured by quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR and immunohistochemistry. Conclusions Our data suggest that CTLs respond to melanoma and melanocytes equally in vitro and directly ex vivo.

  20. Immunotherapy of metastatic melanoma by reversal of immune suppression

    Energy Technology Data Exchange (ETDEWEB)

    Biggs, M.W.; Eiselein, J.E.

    1997-01-01

    Beginning with the observation that the human enteorvirus, Poliovirus Sabin 1, will lyse human melanoma cells in culture, clinical trials involving two patients with advance melanoma were performed. Parenteral injection of the viable Poliovirus into cutaneous melanoma metastases followed in 24 hours by oral administration of cyclophosphamide. The results of these two trials are described.

  1. MicroRNA Expression Profile in Conjunctival Melanoma

    DEFF Research Database (Denmark)

    Larsen, Ann-Cathrine; Mikkelsen, Lauge H.; Borup, Rehannah

    2016-01-01

    Purpose: Conjunctival melanoma (CM) is a rare disease associated with considerable mortality. As opposed to cutaneous melanoma, the epigenetic mechanisms involved in the development of CM and other mucosal melanomas (MMs) are unclear. The purpose of this study was to identify tumor-specific and p...

  2. Prensa de papel frente a prensa en internet

    OpenAIRE

    Porcel Martos, Manuel

    2015-01-01

    Desde finales del siglo XX, Internet y las nuevas tecnologías de la información y de la comunicación han propiciado un nuevo escenario en el que el periodismo, gracias a la inmediatez que proporciona la Red, ha buscado nuevas formas de comunicar, adaptán-dose a un nuevo contexto y forma de escribir, leer, ver y escuchar las producciones pe-riodísticas, reduciendo de manera continuada, drástica y sin opción de retroceso la com-pra de la prensa diaria en papel. Las limitaciones que el period...

  3. Publicidad sexista. El papel de la mujer en publicidad

    OpenAIRE

    María Rodríguez, Laura

    2013-01-01

    Proyecto Fin de Grado leído en la Universidad Rey Juan Carlos en el curso académico 2013/2014. Director: María Sánchez Hernández El estudio realizado trata sobre el discurso sexista que continua presente en la publicidad española. Analizamos los diferentes estereotipos y roles que se asocian a cada género y el papel de la mujer en los anuncios emitidos por televisión. La investigación recoge estudios relacionados cuyos resultados reflejan el alto contenido sexista Ciencias de la Comunic...

  4. El papel de las redes sociales en los movimientos sociales

    OpenAIRE

    Arrate Cobo, Aroa

    2016-01-01

    Las Redes Sociales cada vez están mas presentes en nuestras vidas, marcando un antes y un después con su llegada. Teniendo esto en cuenta, en este Trabajo de Fin de Grado, se propone un análisis sobre el papel de las redes sociales en los Movimientos Sociales. Para ello se ha realizado una investigación de algunos de los últimos movimientos sociales más presentes en las redes. Esta se completa con entrevistas a participantes de estos movimientos, al objeto de contrastar los datos ...

  5. Como queimar um papel à luz de Sírio

    Directory of Open Access Journals (Sweden)

    Guilherme de Almeida

    2013-07-01

    Full Text Available http://dx.doi.org/10.5007/2175-7941.2013v30n2p440 É bem conhecida a experiência de queimar um papel com uma lupa. Será possível, com uma lupa gigantesca, fazer o mesmo utilizando a luz de uma outra estrela? Que requisitos serão necessários? Este artigo aborda as diversas perspectivas sobre o assunto, mostrando as limitações e as possibilidades práticas de tal procedimento. Trata-se de uma exploração conceitual e não de um projeto construtivo.

  6. El papel de la familia en trastornos alimentarios

    OpenAIRE

    Vázquez Arévalo, Rosalia

    1997-01-01

    La familia representa un específico e importante contexto social dentro del cual las conductas y actitudes relacionadas con el peso, apariencia física y alimentación suelen gestarse; de ahí, la relevancia de estudios que expliquen el papel de la familia en los trastornos alimentarios. Tres dimensiones de la vida familiar parecen importantes para este tipo de trastornos, los cuales fueron los objetivos a evaluar en la presente investigación: las actitudes paternas hacia el peso, la dinámica fa...

  7. Investigación científica sobre genotipificación y distribución de Giardia intestinalis en humanos y caninos de América

    Directory of Open Access Journals (Sweden)

    Giovanny Torres Lindarte

    2011-01-01

    Full Text Available Objetivo: Describir la distribución geográfica en América de los genotipos A, B, C y D de Giardia intestinalis hallados en humanos y en perros, y los marcadores y técnicas usadas, de acuerdo con la literatura científica. Materiales y métodos: Revisión sistemática en la que se seleccionaron 19 artículos, y en todos se caracterizaron aislados de humanos; solo 10 de estos caracterizaron aislados de perros. Resultados: México fue el país que más estudios realizó (31,6%. El genotipo A fue reportado en el 89,5% de los trabajos que analizaron aislados de humanos y el genotipo B en el 52,3%. En los que analizaron aislados de perros, el genotipo A se informó en el 60%, el genotipo B en el 20%, el genotipo C en el 30% y el genotipo D en un 20%. La técnica y el marcador más usados fueron la PCR-RFLP y el gen de b-Giardin. Conclusiones: El genotipo A es el responsable de la mayoría de infecciones en humanos como perros de América, aunque los genotipos B, C y D también fueron identificados. El hallazgo de perros infectados con genotipos zoonóticos sustentan su papel como fuentes potenciales de infección de G. intestinalis para humanos.

  8. El reconocimiento del derecho humano a la verdad en El Salvador.

    OpenAIRE

    Arévalo Romero, Leonor Elisa; Reyes Reyes, Gertrudis Ernestina; Trejo Quintana, Densy Samuel

    2009-01-01

    Noción histórica del derecho humano a la verdad -- La idea de la verdad -- El reconocimiento del derecho humano a la verdad en El Salvador -- Marco constitucional y legal de El Salvador en materia del derecho humano a la verdad.

  9. Los derechos humanos laborales en el Derecho Internacional

    Directory of Open Access Journals (Sweden)

    Miguel Canessa Montejo

    2009-12-01

    Full Text Available El presente estudio pretende abordar esa temática desde el horizonte del Derecho internacional. En el primer acápite se plantea un concepto para este selecto grupo de derechos laborales básicos, así como se postulan los argumentos que justifican su reconocimiento jurídico en los instrumentos internacionales de derechos humanos. En el segundo acápite se aborda la identificación de los derechos laborales con los derechos sociales, como una forma de desvalorizar su relevancia jurídica. En el tercer acápite se resaltan las singularidades de los derechos humanos laborales, lo que dificulta someterlos a la clásica división entre derechos civiles y derechos sociales. En el cuarto acápite se establecen las obligaciones internacionales que se desprenden de los derechos humanos laborales hacia los Estados. Asimismo, se hace un breve recorrido sobre los procedimientos internacionales de control y los más importantes pronunciamientos de protección de los derechos humanos laborales. Finalmente, en el último acápite se presenta el jus cogens laboral como pilar del Derecho internacional del trabajo.

  10. Competencias laborales de los gerentes de talento humano

    Directory of Open Access Journals (Sweden)

    Gregorio Calderón Hernández

    2004-01-01

    Full Text Available El reconocimiento de la importancia de las personas en el desarrollo de las organizaciones, especialmente por la posibilidad de construir ventaja competitiva fundamentada en el talento humano, está demandando de quienes lideran el área de recursos humanos el desarrollo de competencias que respondan a los nuevos retos. La revisión de investigaciones realizadas sobre el tema en otras latitudes permite concluir que existen diferentes tipologías de competencias para los profesionales del área de recursos humanos, que no existen estudios específicos de competencias para los gerentes del área y que se puede construir un modelo de competencias a través de análisis cualitativos. Estas consideraciones motivaron la presente investigación, que contó con el apoyo de la Asociación Colombiana de Gestión Humana (ACRIP. Se utilizó una metodología hermenéutica mediante la aplicación de entrevistas de eventos conductuales y de mapa funcional. Los resultados se reflejan en un modelo que comprende cuatro categorías y 18 competencias, además de los valores de los gerentes de talento humano y el diccionario de competencias.

  11. Skinner: sobre ciência e comportamento humano

    Directory of Open Access Journals (Sweden)

    Angelo Augusto Silva Sampaio

    Full Text Available Atualmente, não se pode pensar no estudo do comportamento humano sem considerar a abordagem científica a este objeto: o campo da Psicologia científica. Esse campo é disputado por diversos enfoques teóricos que divergem quanto ao modo como definem ciência e comportamento humano. A abordagem de B. F. Skinner foi bastante proeminente no século XX, mas ainda continua a ser mal-entendida. Partindo do desenvolvimento histórico de sua obra, o presente texto visa a iluminar alguns aspectos relacionados às noções de ciência e comportamento humano desse autor e ressaltar as transformações por que passaram. Analisam-se três tópicos da obra de Skinner: seu período inicial (de 1930 a cerca de 1938, a obra "Ciência e Comportamento Humano" de 1953, e as influências da Biologia. São enfatizados aspectos relevantes da sua teorização sobre o tema: busca por relações funcionais, ênfase nos dados empíricos, operacionismo, externalismo, multideterminação do comportamento, experimentalismo, previsão e controle, ética.

  12. Direitos Humanos e Relações Internacionais

    Directory of Open Access Journals (Sweden)

    Valerio de Oliveira Mazzuoli

    2011-09-01

    Full Text Available O presente artigo tem como tema a incorporação das normas internacionais de proteção dos direitos humanos no ordenamento brasileiro, e os avanços tomados pelo judiciário brasileiro nesse sentido.

  13. Soberania e Direitos Humanos: dois conceitos irreconciliáveis

    Directory of Open Access Journals (Sweden)

    Valerio de Oliveira Mazzuoli

    2011-09-01

    Full Text Available O presente artigo busca analisar a relação contemporânea entre os Estados Nacionais e a proteção internacional dos Direitos Humanos, tendo como foco as questões de soberania.

  14. Macroscopic spectral imaging and gene expression analysis of the early stages of melanoma.

    OpenAIRE

    Yang, P.; Farkas, D. L.; Kirkwood, J. M.; Abernethy, J. L.; Edington, H. D.; Becker, D.

    1999-01-01

    BACKGROUND: The stages of melanocytic progression are defined as atypical (dysplastic) nevus, melanoma in situ, melanoma in the radial growth phase (RGP), melanoma in the vertical growth phase (VGP), and melanoma in the metastatic growth phase (MGP). Melanoma in situ and RGP melanoma often develop in contiguous association with atypical nevi. This frequently poses a problem with respect to their early detection. Furthermore, unlike cells obtained from VGP and MGP melanomas, cells derived from...

  15. Antioxidants can increase melanoma metastasis in mice.

    Science.gov (United States)

    Le Gal, Kristell; Ibrahim, Mohamed X; Wiel, Clotilde; Sayin, Volkan I; Akula, Murali K; Karlsson, Christin; Dalin, Martin G; Akyürek, Levent M; Lindahl, Per; Nilsson, Jonas; Bergo, Martin O

    2015-10-07

    Antioxidants in the diet and supplements are widely used to protect against cancer, but clinical trials with antioxidants do not support this concept. Some trials show that antioxidants actually increase cancer risk and a study in mice showed that antioxidants accelerate the progression of primary lung tumors. However, little is known about the impact of antioxidant supplementation on the progression of other types of cancer, including malignant melanoma. We show that administration of N-acetylcysteine (NAC) increases lymph node metastases in an endogenous mouse model of malignant melanoma but has no impact on the number and size of primary tumors. Similarly, NAC and the soluble vitamin E analog Trolox markedly increased the migration and invasive properties of human malignant melanoma cells but did not affect their proliferation. Both antioxidants increased the ratio between reduced and oxidized glutathione in melanoma cells and in lymph node metastases, and the increased migration depended on new glutathione synthesis. Furthermore, both NAC and Trolox increased the activation of the small guanosine triphosphatase (GTPase) RHOA, and blocking downstream RHOA signaling abolished antioxidant-induced migration. These results demonstrate that antioxidants and the glutathione system play a previously unappreciated role in malignant melanoma progression. Copyright © 2015, American Association for the Advancement of Science.

  16. Selenium for the Prevention of Cutaneous Melanoma

    Directory of Open Access Journals (Sweden)

    Douglas Grossman

    2013-03-01

    Full Text Available The role of selenium (Se supplementation in cancer prevention is controversial; effects often depend on the nutritional status of the subject and on the chemical form in which Se is provided. We used a combination of in vitro and in vivo models to study two unique therapeutic windows for intervention in the process of cutaneous melanomagenisis, and to examine the utility of two different chemical forms of Se for prevention and treatment of melanoma. We studied the effects of Se in vitro on UV-induced oxidative stress in melanocytes, and on apoptosis and cell cycle progression in melanoma cells. In vivo, we used the HGF transgenic mouse model of UV-induced melanoma to demonstrate that topical treatment with l-selenomethionine results in a significant delay in the time required for UV-induced melanoma development, but also increases the rate of growth of those tumors once they appear. In a second mouse model, we found that oral administration of high dose methylseleninic acid significantly decreases the size of human melanoma xenografts. Our findings suggest that modestly elevation of selenium levels in the skin might risk acceleration of growth of incipient tumors. Additionally, certain Se compounds administered at very high doses could have utility for the treatment of fully-malignant tumors or prevention of recurrence.

  17. Vemurafenib for the treatment of melanoma.

    LENUS (Irish Health Repository)

    Jordan, Emmet John

    2012-12-01

    Metastatic melanoma is an aggressive disease resistant to chemotherapy. Recent clinical trials have reported improved survival for two novel agents; ipilimumab, a humanized, IgG1 monoclonal antibody that blocks cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and vemurafenib , a BRAF (v-raf murine sarcoma viral oncogene homolog B1) inhibitor targeting an activating mutation in the serine-threonine-protein kinase BRAF gene. AREAS COVERED: The authors reviewed preclinical and clinical data examining the safety of vemurafenib in melanoma. MEDLINE and EMBASE were searched using the medical subject heading \\'vemurafenib\\' and the following text terms: melanoma, BRAF inhibition, vemurafenib. This review provides the reader with an overview of current data examining the efficacy and safety of vemurafenib in metastatic melanoma. EXPERT OPINION: Vemurafenib is an oral agent licensed for patients with BRAF V600E mutation-positive inoperable and metastatic melanoma. The most common adverse effects observed in Phase III clinical trials were dermatological events, arthralgia and fatigue. Specific dermatological toxicities included development of cutaneous squamous cell cancers and keratoacanthomas. Prolongation of the QT interval was also reported. Regular dermatological assessments and electrocardiograms are recommended. Ongoing trials are examining vemurafenib in both the adjuvant setting and metastatic setting in combination with ipilimumab and MEK inhibitors (mitogen-activated protein kinase\\/extracellular signal-regulated kinase). Understanding and overcoming mechanisms of resistance to BRAF inhibitors is the focus of ongoing research.

  18. [Novel Adjuvant Therapy for Ocular Melanoma].

    Science.gov (United States)

    Bosch, Jacobus J; Heindl, Ludwig M

    2017-05-01

    Background Malignant melanoma is the most common cancer of the eye in adults that originates either in the intra-ocular uveal tract or extra-ocular conjunctiva. Although the primary tumor can be treated successfully, no effective therapy for both metastatic conjunctival and uveal melanoma currently exits. Tumor-associated lymphangiogenesis and immune cell infiltration play a pivotal role in the development and therapeutic targeting of metastases. Project description Here, we provide an overview of current translational research on lymphangiogenesis and its therapeutic inhibition as well as modulation of immune cell infiltration by passive and active immunotherapy in melanoma of the eye. Specifically, our previous and ongoing work on lymphangiogenesis and immune cells in ocular melanoma within the clinical research unit FOR 2240 "(Lymph)Angiogenesis and Cellular Immunity in Inflammatory Diseases of the Eye" is summarized. Conclusions Translational research on the modulation of tumor-associated lymphangiogenesis and immune cell infiltration could provide novel targets for adjuvant therapy in melanoma of the eye. Georg Thieme Verlag KG Stuttgart · New York.

  19. Metastatic amelanotic nodular melanoma during pregnancy.

    Science.gov (United States)

    Jasaitiene, Daiva; Valiukeviciene, Skaidra; Makstiene, Jurgita; Juodzbaliene, Edita Brone

    2008-01-01

    This case report presents a very aggressive course of amelanotic nodular melanoma during pregnancy resulting in death five months after delivery. A 34 year-old Caucasian woman at 19th week of the second pregnancy was diagnosed having amelanotic nodular melanoma (tumor thickness - 2.5 mm) with metastases to the regional right inguinal lymph node. Amelanotic nodular melanoma represents malignant melanocytic tumor of the skin, which clinically mimics a variety of benign and malignant skin conditions and therefore commonly leads to delayed diagnosis. Though primary tumor was excised immediately, other treatment procedures as radical lymphadenectomy and chemotherapy were delayed, and immunotherapy was not given totally. At the 29th week of pregnancy, the woman via naturalem delivered a healthy female child, and the chemotherapy was started. Since pregnancy limits the prescription of immunotherapy and chemotherapy, the prognosis for melanoma during pregnancy detected later than in the second stage is poor and can be illustrated by our reported case. Such patients seems to be at higher risk to develop metastasis of melanoma in the internal organs and occasionally even in the fetus; therefore, they should be timely informed about that.

  20. Melanomas of the vulva and vagina.

    Science.gov (United States)

    Skovsted, Sasia; Nielsen, Karsten; Blaakær, Jan

    2017-03-01

    Malignant melanoma is a rare type of cancer in the vagina and vulva associated with a poor prognosis due to late diagnosis and early dissemination. Only a limited amount of literature exists on the condition. This study elucidates the effect of current treatment. All patients diagnosed with malignant melanoma in the vagina or vulva at Aarhus University Hospital, Skejby, Denmark, in the period from 1996 to 2013 were included. Data were collected from the electronic patient records and from the Danish Pathology Register. A total of 17 patients were included. The average age at the time of diagnosis was 77 years and the median overall survival time was 21.9 months. The five-year survival in this study was 17.7%. The majority of the melanomas were nodular and all of the superficially spreading melanomas were found in the vulva only. Malignant melanoma in the vagina has a poorer prognosis than in the vulva as it is diagnosed later. Early diagnosis and staging of this cancer is important. Positron emission tomography-computed tom-ography should be the standard method for staging the disease. Older women with vaginal discharge should always have a gynaecological examination. The primary treatment is resection of the tumour, but future treatment might be a combination of resection and immunotherapy. none. not relevant.  .

  1. [Molecular and immunohistochemical diagnostics in melanoma].

    Science.gov (United States)

    Schilling, B; Griewank, K G

    2016-07-01

    To provide appropriate therapy and follow-up to patients with malignant melanoma, proper diagnostics are of critical importance. Targeted therapy of advanced melanoma is based on the molecular genetic analyses of tumor tissue. In addition, sequencing of genes and other genetic approaches can provide insight into the origin of melanocytic tumors and can aid in distinguishing benign from malignant lesions. In this regard, spizoid neoplasms remain a challenging entity. Aside from genetic analyses of tumor tissue, immunohistochemistry remains an essential tool in melanoma diagnostics and TNM classification. With new immunotherapies being approved for advanced melanoma, immunohistochemistry to determine PD-L1 expression has gained clinical interest. While PD-L1 expression is associated with response to PD-1 blockade, a substantial number of patients without PD-L1 expression can still experience tumor remission upon treatment. In this review, current and future developments in melanoma diagnostics with regard to molecular genetics and immunohistochemistry are summarized. The utilization of such analyses in clinical decision making is also discussed.

  2. Cure of malignant melanoma by single thermal neutron capture treatment using melanoma-seeking compounds

    International Nuclear Information System (INIS)

    Mishima, Yutaka; Ichihashi, Masamitsu; Nakanishi, Takafumi

    1985-01-01

    Since not only malignant melanomas but also many kinds of human cancers, for example thyroid cancer and squamous cell carcinoma, synthesize their specific protein, much attention has been paid to the establishment of selective thermal neutron capture treatment of malignant melanoma as a prototype of such cancer cells. This paper presents 10 B chlorpromazine compounds and 10 B 1 -para-boronophenylalanine ( 10 B 1 -BPA) as tumor-seeking 10 B compounds which themselves possess selective affinity for the specific metabolic activity of the target cancer cells. An overview of the following studies on the effects of 10 B 1 -BPA in the thermal neutron capture treatment of melanoma is provided: 1) in vitro studies on specific enhanced melanoma cell killing effects of 10 B 1 -BPA; 2) in vivo studies on therapeutic effects of 10 B 1 -BPA using melanoma-bearing hamsters; and 3) preclinical therapeutic experiments using spontaneously occurring malignant melanoma in Duroc pig skin, including experiments in which melanoma was successfully cured. (Namekawa, K.)

  3. Gene expression analyses of primary melanomas reveal CTHRC1 as an important player in melanoma progression

    Science.gov (United States)

    Eriksson, Johanna; Le Joncour, Vadim; Nummela, Pirjo; Jahkola, Tiina; Virolainen, Susanna; Laakkonen, Pirjo; Saksela, Olli; Hölttä, Erkki

    2016-01-01

    Melanoma is notorious for its high tendency to metastasize and its refractoriness to conventional treatments after metastasis, and the responses to most targeted therapies are short-lived. A better understanding of the molecular mechanisms behind melanoma development and progression is needed to develop more effective therapies and to identify new markers to predict disease behavior. Here, we compared the gene expression profiles of benign nevi, and non-metastatic and metastatic primary melanomas to identify any common changes in disease progression. We identified several genes associated with inflammation, angiogenesis, and extracellular matrix modification to be upregulated in metastatic melanomas. We selected one of these genes, collagen triple helix repeat containing 1 (CTHRC1), for detailed analysis, and found that CTHRC1 was expressed in both melanoma cells and the associated fibroblasts, as well as in the endothelium of tumor blood vessels. Knockdown of CTHRC1 expression by shRNAs in melanoma cells inhibited their migration in Transwell assays and their invasion in three-dimensional collagen and Matrigel matrices. We also elucidated the possible down-stream effectors of CTHRC1 by gene expression profiling of the CTHRC1-knockdown cells. Our analyses showed that CTHRC1 is regulated coordinately with fibronectin and integrin β3 by the pro-invasive and -angiogenic transcription factor NFATC2. We also found CTHRC1 to be a target of TFGβ and BRAF. These data highlight the importance of tumor stroma in melanoma progression. Furthermore, CTHRC1 was recognized as an important mediator of melanoma cell migration and invasion, providing together with its regulators—NFATC2, TGFβ, and BRAF—attractive therapeutic targets against metastatic melanomas. PMID:26918341

  4. CDKN2A (INK4A-ARF) mutation analysis to distinguish cutaneous melanoma metastasis from a second primary melanoma.

    NARCIS (Netherlands)

    Blokx, W.A.M.; Lesterhuis, W.J.; Andriessen, M.P.M.; Verdijk, M.A.J.; Punt, C.J.A.; Ligtenberg, M.J.L.

    2007-01-01

    The histologic differential diagnosis between a second primary cutaneous melanoma and cutaneous melanoma metastasis in a patient with a previous history of melanoma can be very difficult. This case report describes the first application of CDKN2A mutation analysis for discriminating a cutaneous

  5. CDKN2A (INK4A-ARF) mutation analysis to distinguish cutaneous melanoma metastasis from a second primary melanoma

    NARCIS (Netherlands)

    Blokx, Willeke A. M.; Lesterhuis, W. Joost; Andriessen, Monique P. M.; Verdijk, Marian A. J.; Punt, Cornelis J. A.; Ligtenberg, Marjolijn J. L.

    2007-01-01

    The histologic differential diagnosis between a second primary cutaneous melanoma and cutaneous melanoma metastasis in a patient with a previous history of melanoma can be very difficult. This case report describes the first application of CDKN2A mutation analysis for discriminating a cutaneous

  6. Papel dos profissionais de saúde na política de humanização hospitalar Papel de los profesionales de salud en la política de humanización hospitalaria The role of health professionals in policies regarding hospital humanization

    Directory of Open Access Journals (Sweden)

    Roberta Araújo Mota

    2006-08-01

    Full Text Available O interesse por este tema surgiu a partir de uma reflexão sobre o papel do profissional de saúde nos atendimentos realizados no ambiente hospitalar, tendo como meta transmitir para esses profissionais informações sobre os cuidados de saúde de uma maneira mais simples e humanizada, e assim levar o bem-estar a todos. O governo adota uma política legal e ética com relação à saúde no país, possuindo um papel fundamental no processo de humanização. Com a proposta de melhorar a qualidade do atendimento nos hospitais, percebemos que estas atividades requerem tempo e conscientização tanto dos profissionais como do governo e pessoas envolvidas no sistema de saúde. Diante desta situação, o psicólogo surge com o papel de resgatar o ser humano para além de sua dimensão físico-biológica e situá-lo num contexto maior de sentido e significado nas suas dimensões psíquicas e sociais.El interés por este tema surgió a partir de una reflexión sobre el papel del profesional de salud en los atendimientos realizados en el ambiente hospitalario, teniendo como meta transmitir a estos profesionales informaciones sobre los cuidados de salud de una manera más simple y humanizada, y así, proporcionar bienestar a todos. El Gobierno adopta una política legal y ética con relación a la salud en el país, teniendo un papel fundamental en el proceso de humanización. Con la propuesta de mejorar la calidad del atendimiento en los hospitales, percibimos que estas actividades requieren tiempo y concienciación, tanto de los profesionales como del Gobierno y personas involucradas en el sistema de salud. Ante esta situación, el psicólogo surge con el papel de rescatar el ser humano más allá de su dimensión físico-biológica y ubicarlo en un contexto mayor de sentido y significado en sus dimensiones psíquicas y sociales.The interest on this theme emerged from a reflection on the role of health professionals in relation to the attendance carried

  7. Relaciones entre el arte y los derechos humanos

    Directory of Open Access Journals (Sweden)

    Yolanda Sierra León

    2014-07-01

    Full Text Available Este artículo se propone reflexionar sumariamente acerca de la vinculación entre el arte y los derechos humanos, teniendo en cuenta el origen o proveniencia de las manifestaciones artísticas. Para el efecto, se consideran tres tipos de obras: 1. Obras originadas en una decisión judicial o estatal como medio de reparación a las víctimas; 2. Obras de arte provenientes de la propia iniciativa de los artistas, y 3. Obras o prácticas artísticas que realizan las víctimas que han sufrido violaciones a sus derechos humanos. Este texto parte de considerar que las obras de arte o las prácticas artísticas, relacionadas con los derechos humanos, tienen objetivos diferentes según sea su origen. Se plantea que el fin del Estado es reparar a las víctimas y contribuir con la garantía de no repetición; mientras que el fin de los artistas es manifestar su sensibilidad en relación con un tema específico que les interesa abordar; y para las víctimas, son mecanismos de resistencia y denuncia que permiten pasar del trauma individual a la conformación de sujetos colectivos con capacidad para incidir en las condiciones sociales que generan la violación a sus derechos humanos. Para pensar el tema, se abordan algunas sentencias del Sistema Interamericano de Derechos Humanos, y obras y prácticas artísticas de víctimas del conflicto armado colombiano.

  8. Conservación de la biodiversidad y desarrollo humano en bosques montanos de Costa Rica

    Directory of Open Access Journals (Sweden)

    Juan Criado Hernández

    2013-05-01

    Full Text Available Costa Rica es el país que posee la mayor biodiversidad del planeta en relación con su extensión (en 51 100 km2 tiene aproximadamente el 5% de la biodiversidad mundial; esto, junto al compromiso político de integrar las políticas de desarrollo humano y de medio ambiente, han consolidado el país como líder en conservación en América Latina.  Lo anterior ha favorecido, además, el desarrollo del ecoturismo, el pago de servicios ambientales y la fijación de carbono, como alternativas para el aprovechamiento racional de los recursos naturales. A pesar de estos esfuerzos, es evidente la necesidad de promover investigaciones que ayuden a entender las interacciones entre naturaleza y sociedad, base del desarrollo sostenible. A escala internacional, los Objetivos de Desarrollo del Milenio (2005, el reciente Congreso de Áreas Protegidas en Mesoamérica (Panamá, 2006 y el último Congreso de la Asociación de Biología Tropical y Conservación (México, 2007, son algunos ejemplos que destacan esta misma necesidad. Se presenta una aproximación interdisciplinar para determinar las relaciones que existen entre la biodiversidad y el bienestar humano en bosques montanos de Costa Rica. La hipótesis considera que un buen estado de conservación del bosque tiene una correlación positiva con un acceso equitativo a las condiciones necesarias para mejorar el bienestar humano de las comunidades. Para esto, se desarrolla una metodología sencilla basada en un conjunto de indicadores biológicos y sociales. En los indicadores biológicos se considera la estructura del bosque y su relación con especies de aves frugívoras como indicadores funcionales de biodiversidad, debido a su papel como dispersores de semillas en las montañas del trópico. Los indicadores sociales están basados en la participación social, por la función que cumple en la distribución de los beneficios generados por el medio ambiente. Para ello se analizan las redes de participaci

  9. Cerebral metastases from malignant melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, G. (Royal Prince Alfred Hospital, Sydney (Australia). Department of Radiation Oncology Royal Prince Alfred Hospital, Sydney (Australia). Sydney Melanoma Unit); Firth, I. (Royal Prince Alfred Hospital, Sydney (Australia). Department of Medical Oncology); Coates, A. (Royal Prince Alfred Hospital, Sydney (Australia). Department of Radiation Oncology Royal Prince Alfred Hospital, Sydney (Australia). Sydney Melanoma Unit)

    1993-03-01

    A retrospective study was undertaken of factors affecting survival in 129 patients with cerebral metastases from malignant melanoma referred to the Department of Radiation Oncology from June '82-January '90. Their ages ranged from 19-83 years and the time interval form diagnosis of the primary tumour to development of cerebral metastases ranged from 1 month-17 years. Cerebral metastases were apparently solitary in 59 (46%) and multiple in 70 (54%) patients. Craniotomy with resection of tumour was performed in 49 patients, of whom 24 had a solitary cerebral metastasis as the only evidence of disease Most patients (94%) received radiotherapy-course. Median survival of the whole group after detection of cerebral metastases was 5 months (range <1-87+). Univariate analysis indicated that a solitary cerebral metastasis, absence of extracranial disease and tumour resection predicted improved survival, but only surgical intervention was of independent prognostic significance in a multivariate analysis. The effect of cranial irradiation on survival could not be assessed, but the dose of radiation did not influence survival. Of the 10 patients who survived for more than 2 years, 8 had total resection of a solitary cerebral metastasis. (author). 25 refs., 3 figs., 3 tabs.

  10. Detection of desmoplastic melanoma with dermoscopy and reflectance confocal microscopy.

    Science.gov (United States)

    Maher, N G; Solinas, A; Scolyer, R A; Puig, S; Pellacani, G; Guitera, P

    2017-12-01

    Desmoplastic melanoma (DM) is frequently misdiagnosed clinically and often associated with melanoma in situ (MIS). To improve the detection of DM using dermoscopy and reflectance confocal microscopy (RCM). A descriptive analysis of DM dermoscopy features and a case-control study within a melanoma population for RCM feature evaluation was performed blindly, using data obtained between 2005 and 2015. After retrospectively identifying all DM cases with RCM data over the study period (n = 16), a control group of non-DM melanoma patients with RCM data, in a ratio of at least 3 : 1, was selected. The control group was matched by age and primary tumour site location, divided into non-DM invasive melanomas (n = 27) and MIS (n = 27). Invasive melanomas were selected according to the melanoma subtypes associated with the DM cases. The main outcomes were the frequency of melanoma-specific features on dermoscopy for DM; and the odds ratios of RCM features to distinguish DM from MIS and/or other invasive melanomas; or MIS from the combined invasive melanoma group. At least one of the 14 melanoma-specific features evaluated on dermoscopy was found in 100% of DMs (n = 15 DM with dermoscopy). Known RCM melanoma predictors were commonly found in the DMs, such as pagetoid cells (100%) and cell atypia (100%). The RCM feature of spindle cells in the superficial dermis was more common in DM compared with the entire melanoma control group (OR 3.82, 95% CI 1.01-14.90), and particularly compared to MIS (OR 5.48, 95% CI 1.11-32.36). Nucleated cells in the dermis and the RCM correlate of dermal inflammation were also significant RCM features favouring DM over MIS, as well as invasive melanoma over MIS. Dermoscopy and RCM may be useful tools for the identification of DM. Certain RCM features may help distinguish DM from MIS and other invasive melanomas. Larger studies are warranted. © 2017 European Academy of Dermatology and Venereology.

  11. Key points in the dermoscopic diagnosis of hypomelanotic melanoma and nodular melanoma.

    Science.gov (United States)

    Moloney, Fergal J; Menzies, Scott W

    2011-01-01

    Nodular melanoma (NM) and amelanotic/hypomelanotic melanoma (AHM) often present a challenge to the diagnosing clinician. A significant proportion of AHM are nodular in nature. Such tumors may lack features of asymmetry and altered peripheral pigmentation routinely observed in other melanoma subtypes. This lack of distinguishing clinical features can potentially result in delayed diagnosis or inappropriate treatment. This review highlights the key points in evaluating the range of lesions where AHM or NM are considered in the differential diagnosis and summarizes current evidence in relation to pigmented and vascular dermoscopic diagnostic criteria for both. © 2011 Japanese Dermatological Association.

  12. Creencias sobre los derechos humanos en estudiantes universitarios de la ciudad de Lima (Beliefs about human rights in college students in Lima

    Directory of Open Access Journals (Sweden)

    Gissela Vilchez Choquehuayta

    2014-06-01

    Full Text Available RESUMEN: En el presente estudio se planteó como objetivo explorar el nivel de información y las creencias sobre los derechos humanos en dos grupos de estudiantes universitarios de una universidad privada de Lima. Un grupo asistió a un curso de Ética y Ciudadanía en el que se abordó temas relativos a los derechos humanos y el otro grupo no. Mediante un cuestionario y entrevistas se exploró la información y creencias de los estudiantes sobre la utilidad e importancia de los derechos humanos, el respeto y las violaciones a los mismos y su percepción sobre el curso de Ética y Ciudadanía. La investigación muestra una clara diferencia entre los grupos con respecto a la utilidad e importancia que le atribuyen a los derechos humanos dentro de la formación profesional. Sin embargo, se identificó también, que ambos grupos presentan dificultades en el nivel de información y ciertos prejuicios acerca del papel que la educación, en derechos humanos, tiene para su desarrollo como profesionales y ciudadanos. El artículo aborda las implicancias de estos hallazgos para el cambio de creencias y la educación en este tema. ABSTRACT: The purpose of this study was to explore the level of information and beliefs about human rights among two groups of college students of a private university in Lima city. One group took the course of «Ethics and Citizenship», here they spoke about human right issues, while the other did not. Through interviews and a questionnaire, students’ beliefs were explored in three areas: a beliefs about thevalue and importance of human rights; b beliefs about respect for human rights and human rights violations; c perception of the course «Ethics and Citizenship». The research shows a clear difference between the groups in terms of the importance andusefulness attributed to human rights as part of their professional training. However, it was identified that in both groups there are some problems at the level of

  13. O PAPEL POLÍTICO DO EDUCADOR: GRAMSCI E ADORNO

    Directory of Open Access Journals (Sweden)

    Fatima Maria Nobre Lopes

    2017-03-01

    Full Text Available O presente artigo objetiva demonstrar, a partir das posições de Gramsci e de Adorno, a importância do papel político do educador para o fortalecimento de um novo bloco histórico e para a formação do pensamento crítico, reflexivo, esclarecido e autônomo dos indivíduos, contribuindo para descortinar a realidade aparente e para a geração de um novo mundo social. Nesse sentido, fica claro que a prática do educador não pode ser neutra diante da realidade educacional e social, pois o trabalho pedagógico é essencialmente político tenha ou não o educador consciência disso. Portanto, a formação da consciência esclarecida e autônoma não é espontânea, nem natural, e sim exige o auxílio de elementos externos cuja mediação central se dá pela educação, daí a especificidade do papel político do educador.

  14. Bioelectric Applications for Treatment of Melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Beebe, Stephen J., E-mail: sbeebe@odu.edu; Schoenbach, Karl H.; Heller, Richard [Frank Reidy Research Center for Bioelectrics/Old Dominion University 4211 Monarch Way, Suite 300, Norfolk, Virginia 23508 (United States)

    2010-09-27

    Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT) or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs). EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in mice. Applications of bioelectrics, using conventional electroporation and extensions of it, provide effective alternative therapies for melanoma.

  15. Bioelectric Applications for Treatment of Melanoma

    International Nuclear Information System (INIS)

    Beebe, Stephen J.; Schoenbach, Karl H.; Heller, Richard

    2010-01-01

    Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT) or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs). EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in mice. Applications of bioelectrics, using conventional electroporation and extensions of it, provide effective alternative therapies for melanoma

  16. Bioelectric Applications for Treatment of Melanoma

    Directory of Open Access Journals (Sweden)

    Richard Heller

    2010-09-01

    Full Text Available Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs. EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in mice. Applications of bioelectrics, using conventional electroporation and extensions of it, provide effective alternative therapies for melanoma.

  17. Cytogenetics of melanoma and nonmelanoma skin cancer.

    Science.gov (United States)

    Carless, Melanie A; Griffiths, Lyn R

    2014-01-01

    Cytogenetic analysis of melanoma and nonmelanoma skin cancers has revealed recurrent aberrations, the frequency of which is reflective of malignant potential. Highly aberrant karyotypes are seen in melanoma, squamous cell carcinoma, actinic keratosis, Merkel cell carcinoma and cutaneous lymphomas with more stable karyotypes seen in basal cell carcinoma, keratoacanthoma, Bowen's disease and dermatofibrosarcoma protuberans. Some aberrations are common among a number of skin cancer types including rearrangements and numerical abnormalities of chromosome 1, -3p, +3q, partial or entire trisomy 6, trisomy 7, +8q, -9p, +9q, partial or entire loss of chromosome 10, -17p, +17q and partial or entire gain of chromosome 20. Combination of cytogenetic analysis with other molecular genetic techniques has enabled the identification of not only aberrant chromosomal regions, but also the genes that contribute to a malignant phenotype. This review provides a comprehensive summary of the pertinent cytogenetic aberrations associated with a variety of melanoma and nonmelanoma skin cancers.

  18. Orbital melanoma with calcification: A diagnostic dilemma

    Directory of Open Access Journals (Sweden)

    Sukhdeep Bains

    2016-01-01

    Full Text Available Primary orbital melanoma is rare and has varied initial presentation. A 28-year-old female presented with proptosis and decreased vision in the left eye. Computed tomography scan showed an orbital mass with contrast enhancement and calcification around the optic nerve leading to a diagnosis of meningioma. The patient chose to be on observation. Loss of vision with an increase in proptosis was seen at 6 months follow-up. On surgical exploration, a well-defined pigmented mass was seen encasing the optic nerve. Histopathological analysis revealed a malignant melanoma. Metastatic workup was negative. Left eye lid sparing exenteration was done. A high index of suspicion is necessary in a rapidly growing suspected optic nerve sheath meningioma and a differential diagnosis including orbital melanoma be considered.

  19. Optic nerve invasion of uveal melanoma

    DEFF Research Database (Denmark)

    Lindegaard, Jens; Isager, Peter; Prause, Jan Ulrik

    2007-01-01

    The aim of the study was to identify the histopathological characteristics associated with the invasion of the optic nerve of uveal melanoma and to evaluate the association between invasion of the optic nerve and survival. In order to achieve this, all uveal melanomas with optic nerve invasion...... in Denmark between 1942 and 2001 were reviewed (n=157). Histopathological characteristics and depth of optic nerve invasion were recorded. The material was compared with a control material from the same period consisting of 85 cases randomly drawn from all choroidal/ciliary body melanomas without optic nerve...... invasion. Prelaminar/laminar optic nerve invasion was in multivariate analysis associated with focal retinal invasion, neovascularization of the chamber angle, and scleral invasion. Postlaminar invasion was further associated with non-spindle cell type and rupture of the inner limiting membrane...

  20. Axillary Silicone Granulomas in Patients With Melanoma.

    Science.gov (United States)

    Fernández Canedo, M I; Blázquez Sánchez, N; Valdés Solís, P; de Troya Martín, M

    2016-05-01

    Subcutaneous lesions may be detected during follow-up of patients with melanoma. The main entities that should be contemplated in the differential diagnosis in such cases are in-transit and regional lymph node metastases. We describe 2 cases of women with breast implants who developed palpable subcutaneous lesions in the axillary region during follow-up of melanoma. In both cases, the ultrasound study showed diffuse hyperechoic signals forming the characteristic snowstorm sign in the subcutaneous tissue. Ultrasound proved to be a key diagnostic tool for ruling out melanoma-related disease, such as in-transit metastases and regional lymph node metastases. Copyright © 2015 Elsevier España, S.L.U. y AEDV. All rights reserved.

  1. Melanoma of the Hand: Current Practice and New Frontiers

    Directory of Open Access Journals (Sweden)

    John Brad Turner

    2014-03-01

    Full Text Available Melanoma of the hand represents a complicated clinical entity. Anatomic features of the hand create challenges in successful management of melanoma not encountered elsewhere in the body. The objectives of this article are to outline current standards for managing melanoma of the hand including diagnosis, surgical, and chemotherapeutic management. Particular emphasis will be placed on currently debated topics of the role of sentinel lymph node biopsy, the role of Mohs micrographic surgery, tissue sparing management of subungual melanoma, and the consideration of melanoma of the hand as a distinct entity based on clinical and molecular studies.

  2. Oral malignant melanoma: A rare case report and review

    Directory of Open Access Journals (Sweden)

    Mangala Rakaraddi

    2011-01-01

    Full Text Available Primary malignant melanoma is only rarely found in oral cavity (estimated between 0.2 and 8-0% of all melanomas and occurs approximately four times more frequently in oral mucosa of the upper jaw, usually on the palate, alveolar gingiva and melanoma of mandibular gingiva is extremely rare. The peak age of diagnosis of melanoma is between 55 and 65 years. A biopsy is required to confirm the diagnosis. Here, we present a rare case of malignant melanoma of mandibular gingiva in a 64-year-old female patient which is confirmed by histopathology.

  3. Current Research and Development of Chemotherapeutic Agents for Melanoma

    Directory of Open Access Journals (Sweden)

    Kyaw Minn Hsan

    2010-04-01

    Full Text Available Cutaneous malignant melanoma is the most lethal form of skin cancer and an increasingly common disease worldwide. It remains one of the most treatment-refractory malignancies. The current treatment options for patients with metastatic melanoma are limited and in most cases non-curative. This review focuses on conventional chemotherapeutic drugs for melanoma treatment, by a single or combinational agent approach, but also summarizes some potential novel phytoagents discovered from dietary vegetables or traditional herbal medicines as alternative options or future medicine for melanoma prevention. We explore the mode of actions of these natural phytoagents against metastatic melanoma.

  4. Stereological estimates of nuclear volume in thin malignant melanomas

    DEFF Research Database (Denmark)

    Björnhagen, V; Månsson-Brahme, E; Lindholm, J

    1998-01-01

    melanomas were individually compared with 33 thin non-metastasizing melanomas after individual matching of cases with one or two randomly chosen controls for site of primary tumour, tumour thickness, level of invasion, tumour regression and follow-up. Conditional logistic regression analysis showed......Stereological estimation of nuclear volume was performed in a case control study of 72 malignant melanomas, thickness melanomas due to too sparse cellularity. Thus, 21 thin metastasizing...... no significant differences in nuclear volume between metastasizing and non-metastasizing thin malignant melanomas....

  5. Circulating tumor cells in melanoma patients.

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    Gary A Clawson

    Full Text Available Circulating tumor cells (CTCs are of recognized importance for diagnosis and prognosis of cancer patients. With melanoma, most studies do not show any clear relationship between CTC levels and stage of disease. Here, CTCs were enriched (∼400X from blood of melanoma patients using a simple centrifugation device (OncoQuick, and 4 melanocyte target RNAs (TYR, MLANA, MITF, and MIF were quantified using QPCR. Approximately one-third of melanoma patients had elevated MIF and MLANA transcripts (p<0.0001 and p<0.001, respectively compared with healthy controls. In contrast, healthy controls had uniformly higher levels of TYR and MITF than melanoma patients (p<0.0001. There was a marked shift of leukocytes into the CTC-enriched fractions (a 430% increase in RNA recovery, p<0.001, and no relationship between CTC levels and stage of disease was found. CTCs were captured on microfabricated filters and cultured. Captured melanoma CTCs were large cells, and consisted of 2 subpopulations, based on immunoreactivity. One subpopulation (∼50% stained for both pan-cytokeratin (KRT markers and the common leukocyte marker CD-45, whereas the second subpopulation stained for only KRT. Since similar cells are described in many cancers, we also examined blood from colorectal and pancreatic cancer patients. We observed analogous results, with most captured CTCs staining for both CD-45/KRT markers (and for the monocyte differentiation marker CD-14. Our results suggest that immature melanocyte-related cells (expressing TYR and MITF RNA may circulate in healthy controls, although they are not readily detectable without considerable enrichment. Further, as early-stage melanomas develop, immature melanocyte migration into the blood is somehow curtailed, whereas a significant proportion of patients develop elevated CTC levels (based on MIF and MLANA RNAs. The nature of the captured CTCs is consistent with literature describing leukocyte/macrophage-tumor cell fusion hybrids

  6. Melanoma biomolecules: independently identified but functionally intertwined

    Directory of Open Access Journals (Sweden)

    Danielle Erin Dye

    2013-09-01

    Full Text Available The majority of patients diagnosed with melanoma present with thin lesions and generally these patients have a good prognosis. However, 5% of patients with early melanoma (< 1mm thick will have recurrence and die within 10 years, despite no evidence of local or metastatic spread at the time of diagnosis. Thus, there is a need for additional prognostic markers to help identify those patients that may be at risk of recurrent disease. Many studies and several meta-analyses have compared gene and protein expression in melanocytes, naevi, primary and metastatic melanoma in an attempt to find informative prognostic markers for these patients. However, although a large number of putative biomarkers have been described, few of these molecules are informative when used in isolation. The best approach is likely to involve a combination of molecules. We believe one approach could be to analyze the expression of a group of interacting proteins that regulate different aspects of the metastatic pathway. This is because a primary lesion expressing proteins involved in multiple stages of metastasis may be more likely to lead to secondary disease than one that does not. This review focuses on five putative biomarkers - melanoma cell adhesion molecule (MCAM, galectin-3 (gal-3, matrix metalloproteinase 2 (MMP-2, chondroitin sulfate proteoglycan 4 (CSPG4 and paired box 3 (PAX3. The goal is to provide context around what is known about the contribution of these biomarkers to melanoma biology and metastasis. Although each of these molecules have been independently identified as likely biomarkers, it is clear from our analyses that each are closely linked with each other, with intertwined roles in melanoma biology.

  7. Ensaio sobre desenvolvimento humano na pós-modernidade Ensayo sobre desarrollo humano en la pos-modernidad Essay on human development in the post-modernity

    Directory of Open Access Journals (Sweden)

    José Antônio Damásio Abib

    2008-09-01

    Full Text Available Neste ensaio, o conceito de desenvolvimento humano na pós-modernidade apóia-se em uma filosofia pós-moderna de direitos humanos, e na modernidade apóia-se em uma filosofia moderna de direitos humanos. O Estado moderno fracassou na realização da filosofia moderna dos direitos humanos. Uma filosofia pós-moderna de direitos humanos deixa para trás a filosofia moderna de direitos humanos. Isso significa abandonar o fundacionismo ético e as grandes narrativas emancipatórias de desenvolvimento humano. Sugerimos que uma ética pragmatista da alteridade e uma política pós-moderna da alteridade podem contribuir para elaborar uma filosofia pós-moderna de direitos humanos.En este ensayo, el concepto de desarrollo humano en el pos-modernidad es apoyado en una filosofía pos-moderna de los derechos humanos y en la modernidad, es apoyado en una filosofía moderna de los derechos humanos. El Estado moderno fracasó en la realización de la filosofía moderna de los derechos humanos. Una filosofía pos-moderna de derechos humanos deja atrás la filosofía moderna de derechos humanos. Lo que significa abandonar el fundacionismo ético y las grandes narrativas emancipatorias del desarrollo humano. Sugerimos que una ética pragmatista de la alteridad y una política pos-moderna de alteridad pueden contribuir en la elaboración de una filosofía pos-moderna de derechos humanos.Whereas the concept of human development in post-modernity is supported by a post-modern philosophy of human rights, in modernity it is supported by a modern philosophy of human rights. The modern State has failed in the modern philosophy of human rights and the post-modern philosophy of human rights has laid aside a modern philosophy of human rights. This means that ethical foundationalism and emancipatory great narratives of human development have been discarded. We suggest that a pragmatist ethics of alterity and a post-modern policy of alterity may be a help in the

  8. Metastatic melanoma and vemurafenib: novel approaches

    Directory of Open Access Journals (Sweden)

    Ramon Andrade De Mello

    2012-04-01

    Full Text Available Metastatic melanoma (MM presents a treatment challenge to oncologists worldwide. Dacarbazine is the first line chemotherapy treatment for MM, though the overall response rates are very poor. Recently, the v-raf murine sarcoma viral oncogene homolog B1 (BRAF V600 mutation was found to play a main role in MM. This mutation is present in 40-60% of melanoma patients. Vemurafenib is a BRAF kinase inhibitor that showed impressive results in phase I-III trials and was thus recently approved for the treatment of MM. This paper will briefly focus on vemurafenib in the treatment of MM and highlight concerns.

  9. Canine olfactory detection of malignant melanoma

    Science.gov (United States)

    Campbell, Leon Frederick; Farmery, Luke; George, Susannah Mary Creighton; Farrant, Paul B J

    2013-01-01

    Our patient is a 75-year-old man who presented after his pet dog licked persistently at an asymptomatic lesion behind his right ear. Examination revealed a nodular lesion in the postauricular sulcus. Histology confirmed malignant melanoma, which was subsequently excised. Canine olfactory detection of human malignancy is a well-documented phenomenon. Advanced olfaction is hypothesised to explain canine detection of bladder, breast, colorectal, lung, ovarian, prostate and skin cancers. Further research in this area may facilitate the development of a highly accurate aid to diagnosis for many malignancies, including melanoma. PMID:24127369

  10. [Diagnostic Approaches to Suspected Choroidal Melanoma].

    Science.gov (United States)

    Girbardt, C; Rehak, M; Wiedemann, P

    2017-03-10

    Whenever funduscopy reveals possible choroidal melanoma, all available information must be gathered to either confirm or exclude the diagnosis. Well-defined funduscopic criteria are available, which can already lead to a high degree of diagnostic certainty. Additional technical examinations can be used to exclude possible differential diagnoses. In cases where no clear diagnosis can be established, it is possible to take a biopsy or to watch and wait in order to observe possible growth. Whenever the diagnosis of a choroidal melanoma is established, cancer staging has to be performed in order to search for possible metastases. Georg Thieme Verlag KG Stuttgart · New York.

  11. Intercellular crosstalk in human malignant melanoma

    Czech Academy of Sciences Publication Activity Database

    Dvořánková, Barbora; Szabo, Pavol; Kodet, O.; Strnad, Hynek; Kolář, Michal; Lacina, L.; Krejčí, E.; Nanka, O.; Sedo, A.; Smetana, K.

    2017-01-01

    Roč. 254, č. 3 (2017), s. 1143-1150 ISSN 0033-183X R&D Projects: GA ČR GA16-05534S; GA MŠk(CZ) LQ1604; GA MŠk(CZ) ED1.1.00/02.0109 Grant - others:GA MŠk(CZ) LM2015042 Institutional support: RVO:68378050 Keywords : Melanocyte * Melanoma cells * Melanoma ecosystem * cancer -associated fibroblast * Keratinocyte * Cytokine Subject RIV: EB - Genetics ; Molecular Biology OBOR OECD: Cell biology Impact factor: 2.870, year: 2016

  12. BAP1 PLAYS A SURVIVAL ROLE IN CUTANEOUS MELANOMA

    Science.gov (United States)

    Kumar, Raj; Taylor, Michael; Miao, Benchun; Ji, Zhenyu; Njauw, Jenny Ching-Ni; Jönsson, Göran; Frederick, Dennie Tompers; Tsao, Hensin

    2014-01-01

    Although the pattern of BAP1 inactivation in ocular melanoma specimens and in the BAP1 cutaneous/ocular melanoma (CM/OM) predisposition syndrome suggests a tumor suppressor function, the specific role of this gene in the pathogenesis of cutaneous melanoma is not fully understood. We thus set out to characterize BAP1 in cutaneous melanoma and discovered an unexpected pro-survival effect of this protein. Tissue and cell lines analysis showed that BAP1 expression was maintained, rather than lost, in primary melanomas compared to nevi and normal skin. Genetic depletion of BAP1 in melanoma cells reduced proliferation and colony forming capability, induced apoptosis and inhibited melanoma tumor growth in vivo. On the molecular level, suppression of BAP1 led to a concomitant drop in the protein levels of survivin a member of anti-apoptotic proteins and a known mediator of melanoma survival. Restoration of survivin in melanoma cells partially rescued the growth-retarding effects of BAP1 loss. In contrast to melanoma cells, stable overexpression of BAP1 into immortalized but non-transformed melanocytes did suppress proliferation and reduce survivin. Taken together, these studies demonstrate that BAP1 may play a growth-sustaining role in melanoma cells, but that its impact on ubiquitination underpins a complex physiology which is context and cell dependent. PMID:25521456

  13. Efficient adenovector CD40 ligand immunotherapy of canine malignant melanoma.

    Science.gov (United States)

    von Euler, Henrik; Sadeghi, Arian; Carlsson, Björn; Rivera, Patricio; Loskog, Angelica; Segall, Thomas; Korsgren, Olle; Tötterman, Thomas H

    2008-05-01

    Cutaneous canine melanomas are usually benign in contrast to human malignant melanoma. However, the canine oropharyngeal, uveal, and mucocutaneous neoplasms are aggressive and have metastatic potential. Surgery and to a lesser extent radiotherapy and chemotherapy are widely adopted treatments but are seldom curative in advanced stages. The similarities between human and canine melanoma make spontaneous canine melanoma an excellent disease model for exploring novel therapies. Herein, we report the first 2 adenovector CD40L immunogene (AdCD40L) treatments of aggressive canine malignant melanoma. Case no. 1 was an advanced stage III oral melanoma that was cured from malignant melanoma with 2 intratumor AdCD40L injections before cytoreductive surgery. After treatment, the tumor tissue was infiltrated with T lymphocytes and B lymphocytes suggesting immune activation. This dog survived 401 days after the first round of gene therapy and was free of melanoma at autopsy. Case no. 2 had a conjunctival malignant melanoma with a rapid progression. This case was treated with 6 AdCD40L injections over 60 days. One hundred and twenty days after start of gene therapy and 60 days after the last injection, the tumor had regressed dramatically, and the dog had a minimal tumor mass and no signs of progression or metastasis. Our results indicate that AdCD40L immunogene therapy is beneficial in canine malignant melanoma and could be considered for human malignant melanoma as well.

  14. Ocular melanoma: an overview of the current status

    Science.gov (United States)

    Jovanovic, Predrag; Mihajlovic, Marija; Djordjevic-Jocic, Jasmina; Vlajkovic, Slobodan; Cekic, Sonja; Stefanovic, Vladisav

    2013-01-01

    Ocular melanoma is the second most common type of melanoma after cutaneous and the most common primary intraocular malignant tumor in adults. Large majority of ocular melanomas originate from uvea, while conjunctival melanomas are far less frequent. Incidence of uveal melanoma has remained stable over last three decades. Diagnosis is in most cases established by clinical examination with great accuracy. Local treatment of uveal melanoma has improved, with increased use of conservative methods and preservation of the eye, but survival rates have remained unchanged. Recent advances in cytogenetics and genetics enhanced prognostication and enabled to determine tumors with high metastatic potential. However, due to lack of effective systemic therapy, prognosis of patients with metastasis remains poor and metastatic disease remains the leading cause of death among patients with uveal melanoma. Conjunctival melanoma is rare, but its incidence is increasing. It mostly occurs among white adults. In majority of cases it originates from preceding primary acquired melanosis. Current standard treatment for conjunctival melanoma is wide local excision with adjuvant therapy, including brachytherapy, cryotherapy and topical application of chemotherapeutic agent. Rarity of this tumor limits conduction of controlled trials to define the best treatment modality. As well as for uveal melanoma, prognosis of patients with metastasis is poor because there is no effective systemic therapy. Better understanding of underlying genetic and molecular abnormalities implicated in development and progression of ocular melanomas provides a great opportunity for development of targeted therapy, which will hopefully improve prognosis of patients with metastatic disease. PMID:23826405

  15. Sarcoidosis in Melanoma Patients: Case Report and Literature Review

    Energy Technology Data Exchange (ETDEWEB)

    Beutler, Bryce D., E-mail: brycebeutler@hotmail.com [School of Allied Health Sciences, University of Nevada, Las Vegas, 1060 Wiegand Road, Encinitas, CA 92024 (United States); Cohen, Philip R., E-mail: brycebeutler@hotmail.com [Department of Dermatology, University of California San Diego, 10991 Twinleaf Court, San Diego, CA 92131 (United States)

    2015-06-15

    Sarcoidosis is a systemic inflammatory disease characterized by the development of noncaseating granulomas in multiple organ systems. Many hematologic malignancies and solid tumors, including melanoma, have been associated with sarcoidosis. We describe the clinical and pathologic findings of a 54-year-old man with melanoma-associated sarcoidosis. In addition, we not only review the literature describing characteristics of other melanoma patients with sarcoidosis, but also the features of melanoma patients with antineoplastic therapy-associated sarcoidosis. Sarcoidosis has been described in 80 melanoma patients; sufficient information for analysis was provided in 39 of these individuals. In 43.6% of individuals (17 out of 39), sarcoidosis was directly associated with melanoma; in 56.4% of oncologic patients (22 out of 39), sarcoidosis was induced by antineoplastic therapy that had been administered for the treatment of their metastatic melanoma. The discovery of melanoma preceded the development of sarcoidosis in 12 of the 17 (70.5%) individuals who did not receive systemic treatment. Pulmonary and/or cutaneous manifestations of sarcoidosis were common among both groups of patients. Most patients did not require treatment for sarcoidosis. Melanoma patients—either following antineoplastic therapy or without systemic treatment—may be at an increased risk to develop sarcoidosis. In antineoplastic therapy naive melanoma patients, a common etiologic factor—such as exposure to ultraviolet light—may play a role in their developing melanoma and sarcoidosis.

  16. A new understanding in the epidemiology of melanoma.

    Science.gov (United States)

    Erdei, Esther; Torres, Salina M

    2010-11-01

    The incidence of melanoma is continuing to increase worldwide. UV exposure is a known risk factor for melanoma. Geographic location is known to influence UV exposure and the distribution of the incidence of melanoma. Furthermore, epidemiologic data suggest that gender and genetics may influence the distribution of melanoma on the body surface and histopathologic characteristics of the lesion. This article describes what is known about the impact of gender, ethnicity and geography on the progression of melanoma. Advanced-stage cutaneous melanoma has a median survival time of less than 1 year. Surgical removal, radiotherapy, chemotherapy, targeted therapies and a variety of immunotherapies have been utilized in the treatment of melanoma. Current treatment strategies and the results of recent clinical trials are also discussed in this article.

  17. Infantile melanoma--a triple threat: diagnosis and management.

    Science.gov (United States)

    Lambie, Milena; Nadler, Chad; Glat, Paul; Van Duzer, Scott; Halligan, Gregory; Geller, Evan

    2011-07-01

    Cases of infantile melanoma are very rare, and only a few have been presented in the literature. Pediatric melanoma can present to the clinician as a "triple threat" of delayed diagnosis resulting in thick lesions at risk for metastasis, histologic uncertainty of diagnosis, and a lack of data guiding regional node management and adjuvant therapy. Melanoma in childhood is an uncommon condition, and it is even more atypical in infants. There is evidence however that it is increasing in frequency. We present 2 cases of infantile melanoma diagnosed before age 1 and multidisciplinary management performed at our institution. One child was diagnosed with melanoma arising within a congenital melanocytic nevus, and the other presented with melanoma from a de novo acquired scalp lesion. The ambiguity surrounding correct pathologic diagnosis of melanoma in this age group, and the tendency for late diagnosis with thicker lesions presents special staging and treatment challenges to the team of specialists involved in the care of these children.

  18. Melanoma gástrico sin origen primario conocido

    Directory of Open Access Journals (Sweden)

    Gorka Docio Gregorio

    Full Text Available El melanoma maligno es una neoplasia derivada de los melanocitos, que equivale al 5 % de las neoplasias cutáneas. El 95 % de los melanomas se desarrolla en la piel y menos de 3 % corresponde a melanoma metastásico sin evidencia de tumor primario. En el tracto gastrointestinal, la afectación por melanoma es debido la mayoría de las veces a metástasis. El melanoma primario gastrointestinal está descrito que afecta a la zona anorrectal, seguido de esófago. El melanoma gástrico primario es un tumor excepcional, existen muy pocos casos documentados en la literatura. Presentamos el caso de un paciente con un melanoma en estómago como primera manifestación de la enfermedad y hacemos una revisión del estado actual.

  19. Isolation and Molecular Characterization of Circulating Melanoma Cells

    Directory of Open Access Journals (Sweden)

    Xi Luo

    2014-05-01

    Full Text Available Melanoma is an invasive malignancy with a high frequency of blood-borne metastases, but circulating tumor cells (CTCs have not been readily isolated. We adapted microfluidic CTC capture to a tamoxifen-driven B-RAF/PTEN mouse melanoma model. CTCs were detected in all tumor-bearing mice and rapidly declined after B-RAF inhibitor treatment. CTCs were shed early from localized tumors, and a short course of B-RAF inhibition following surgical resection was sufficient to dramatically suppress distant metastases. The large number of CTCs in melanoma-bearing mice enabled a comparison of RNA-sequencing profiles with matched primary tumors. A mouse melanoma CTC-derived signature correlated with invasiveness and cellular motility in human melanoma. CTCs were detected in smaller numbers in patients with metastatic melanoma and declined with successful B-RAF-targeted therapy. Together, the capture and molecular characterization of CTCs provide insight into the hematogenous spread of melanoma.

  20. Defining the dermoscopic characteristics of fast-growing cutaneous melanomas.

    Science.gov (United States)

    Tejera-Vaquerizo, Antonio; Arias-Santiago, Salvador; Nagore, Eduardo; Martín-Cuevas, Paula; Orgaz-Molina, Javier; Traves, Victor; Herrera-Acosta, Enrique; Naranjo-Sintes, Ramón; Guillén, Carlos; Herrera-Ceballos, Enrique

    2015-06-01

    A high growth rate in melanomas has been associated with a more aggressive phenotype and worse survival. The aim of this study was to define the dermoscopic characteristics associated with this type of cutaneous melanoma. We carried out a retrospective study of 132 cutaneous melanomas, analyzing certain clinical characteristics and the most important dermoscopic variables related to the melanomas. Fast-growing melanomas were considered to be those with a growth rate of more than 0.5 mm per month. Fast-growing melanomas more often lacked an atypical network, were symmetrical, presented ulceration, and were hypopigmented. The dermoscopic vascular pattern often showed atypical irregular vessels and milky-red areas. The association of these two is a specific characteristic. Fast-growing melanomas have a characteristic phenotype and dermoscopy can be useful for their identification.