Electricity labelling according to paragraph 42 EnWG. Amendments in EnWG 2011; Stromkennzeichnung nach paragraph 42 EnWG. Neuerungen im EnWG 2011

Energy Technology Data Exchange (ETDEWEB)

Germer, Christoph [Gersemann und Kollegen, Freiburg im Breisgau (Germany); Reh, Matthias [enwima AG, Berlin (Germany)

2012-07-01

Labelling of electric power is based on the assumption that the end user needs at least one criterion other than the price to distinguish between electric power offered by different providers. The regulations, especially those governing the labelling of electric power from renewable energy sources, have been modified significantly in EnWG 2011. (orig.)

Pulmonary CT findings of Wegener's granulomatosis (WG). Follow-up images and pathology

International Nuclear Information System (INIS)

Uezono, Haruka; Noma, Satoshi; Sakamoto, Ryo

2009-01-01

We reviewed 16 cases of Wegener's granulomatosis (WG) with regard to CT findings, PR3-ANCA, and clinical courses. Because of PR3-ANCA, atypical manifestations of WG could have been diagnosed, including tiny nodules without symptoms and self-remissions. Radiologists should be aware of these atypical manifestations of WG. Seeing multiple nodules in lung, WG should be included in the differential diagnosis and extrapulmonary manifestation of WG should be evaluated. (author)

HERCA WG Medical Applications / Sub WG 'Exposure of Asymptomatic Individuals in Health Care' - 'Position Paper on Screening'

International Nuclear Information System (INIS)

Griebel, Juergen; Ebdon-Jackson, Steve

2012-05-01

Over the course of several meetings the HERCA-Working Group (WG) 'Medical Applications' has discussed the exposure of asymptomatic individuals in health care. In particular, the discussions focused on the issue of the early detection of severe diseases, by use of X-rays, for those who do not present with symptoms. An important and established example is the use of X-ray mammography to detect early breast cancer and this has traditionally been referred to as screening. An emerging application is the use of computed tomography in a range of circumstances, some of which may be better described as a separate category of medical exposure as they are neither diagnostic nor screening in the accepted sense. The discussions have indicated that it is pivotal to clearly define the relevant terms generally applied and to clearly differentiate these terms from diagnostic examinations used in health care. In this context, it is important to note, that the revision of the Euratom Basic Safety Standards (Euratom BSS) Directive is under way and addresses in particular medical radiological procedures on asymptomatic individuals, intended to be performed for early detection of disease (Draft Proposal 29 September 2011 Article 54). Hereby, two types of examinations of asymptomatic individuals, (that in some cases have both been referred to as screening) are addressed: (1) exposures as part of screening programmes and (2) exposures associated with individual health assessment. On adoption, this directive will have significant implications for and a substantial impact on the work of the radiation protection authorities in Europe. In this position paper the WG 'Medical Applications' proposes a clear distinction between screening and radiological procedures as part of an individual health assessment and highlights special requirements for the latter. Finally, the impact on the work of radiation protection authorities in Europe is addressed

Job Grading Standard for Machine Tool Operator, WG-3431.

Science.gov (United States)

Civil Service Commission, Washington, DC. Bureau of Policies and Standards.

The standard covers nonsupervisory work involved in the set up, adjustment, and operation of conventional machine tools to perform machining operations in the manufacture and repair of castings, forgings, or parts from raw stock made of various metals, metal alloys, and other materials. A general description of the job at both the WG-8 and WG-9…

77 FR 29750 - Fifteenth Meeting: RTCA Special Committee 214, Joint With EUROCAE WG-78, Standards for Air...

Science.gov (United States)

2012-05-18

....int no later than May 21, 2012 with the following security information: Last Name/ First name, Organization, ID or Passport number, Details for visiting the Maastricht centre, hotels and how to get here can... , (for hotels please note that the hotel ``Tulip Inn Maastricht Airport'' is next to the runway and the...

76 FR 70531 - Tenth Meeting: RTCA Special Committee 217/EUROCAE WG-44: Terrain and Airport Mapping Databases

Science.gov (United States)

2011-11-14

.... Discussion the differences between AIXM and the Modeling Effort for Terrain and Obstacles within the... structure'' in DO-272. Determine if and how to re-write Appendix E. Review work on Temporality. ASRN V&V... to space availability. With the approval of the chairman, members of the public may present oral...

Study on an optimum ratio of PV output energy to WG output energy in PV/WG hybrid system; Taiyoko/furyoku hybrid hatsuden system no saiteki yoryohi ni kansuru kento

Energy Technology Data Exchange (ETDEWEB)

Nishikawa, S [Kandenko Co. Ltd., Tokyo (Japan)

1996-10-27

A photovoltaic power (PV) and wind generated power (WG) are an unlimited clean energy source, yet their output is unstable depending on the fluctuation of weather conditions such as solar radiation and wind velocity. Consequently, a large-scale power storage equipment is necessitated leading to a high cost especially in an independent system. As a solution, a method is available in which PV and WG are combined so that the effect may be utilized for stabilizing the output of a system as a whole, at a site where a fluctuation pattern is different between photovoltaic energy and wind energy. In building a hybrid system by PV and WG, sites with such supplementary effect existing were selected from the viewpoint of stabilizing the fluctuation of the power generation in the long run; and then, an examination was made on the optimum PV capacity ratio (%Ppo) in each site. As a result, it revealed that the %Ppo had great bearing on a ratio of PV energy fluctuation to WG, which was converted to a numerical formula. A comparatively simple examination by means of meteorological data also indicated that the share ratio was possibly optimized between the quantities of PV and WG energy. 4 refs., 2 figs., 2 tabs.

76 FR 6179 - Eighth Meeting-RTCA Special Committee 217: Joint With EUROCAE WG-44 Terrain and Airport Mapping...

Science.gov (United States)

2011-02-03

..., Spain. The contact person(s) are Maarten Uijt de Haag, Ph.D., Aerospace Research and Technology Center... Politecnica de Catalunya (UPC), Barcelona, Spain, e-mail: [email protected] . EETAC is located in...

75 FR 10552 - Sixth Meeting-RTCA Special Committee 217: Joint With EUROCAE WG-44 Terrain and Airport Mapping...

Science.gov (United States)

2010-03-08

...) Applications Data Quality--Non-Numeric Requirements Data Quality--Numeric Requirements Guidance Materials... Applications Numerical Requirements Guidance Materials Data Quality Wednesday, April 14 Continuation of... Planning SC-214 Requirements Review and Response Planning Thursday, April 15 Document Agreements DO-272...

Reply to INFCE/DEP./WG.8/48

International Nuclear Information System (INIS)

1978-12-01

In replying to questions on WG8/UK/DOC 1, the design basis of the ''continuous refuelling'' is explained, and further comment is made on the disposal of waste silicon carbide and carbonaceous material, resulting from reprocessing operations

Current status of the EPOS WG4 - GNSS and Other Geodetic Data

Science.gov (United States)

Fernandes, Rui; Bastos, Luisa; Bruyninx, Carine; D'Agostino, Nicola; Dousa, Jan; Ganas, Athanassios; Lidberg, Martin; Nocquet, Jean-Mathieu

2014-05-01

WG4 - "EPOS Geodetic Data and Other Geodetic Data" is the Working Group of the EPOS project in charge of defining and preparing the integration of the existing Pan-European Geodetic Infrastructures that will support European Geosciences, which is the ultimate goal of the EPOS project. The WG4 is formed by representatives of the participating EPOS countries (23) but it is also open to the entire geodetic community. In fact, WG4 also already includes members from countries that formally are not integrating EPOS in this first step. The geodetic component of EPOS (WG4) is dealing essentially with Research Infrastructures focused on continuous operating GNSS (cGNSS) in the current phase. The option of concentrating the efforts on the presently most generalized geodetic tool supporting research on Solid Earth was decided in order to optimize the existing resources. Nevertheless, WG4 will continue to pursue the development of tools and methodologies that permit the access of the EPOS community to other geodetic information (e.g., gravimetry). Furthermore, although the focus is on Solid Earth applications, other research and technical applications (e.g., reference frames, meteorology, space weather) can also benefit from the efforts of WG4 EPOS towards the optimization of the geodetic resources in Europe. We will present and discuss the plans for the implementation of the thematic and core services (TCS) for geodetic data within EPOS and the related business plan. We will focus on strategies towards the implementation of the best solutions that will permit to the end-users, and in particular geo-scientists, to access the geodetic data, derived solutions, and associated metadata using transparent and uniform processes. Five pillars have been defined proposed for the TCS: Dissemination, Preservation, Monitoring, and Analysis of geodetic data plus the Support and Governance Infrastructure. Current proposals and remaining open questions will be discussed.

Record of the third meeting of the working group, Palo Alto, California, 1 February 1979

International Nuclear Information System (INIS)

1979-03-01

The items discussed include the report of WG4 to the November Plenary Conference, the draft chapters I to III of the WG4 final report, the progress reports from sub-group A and sub-group B, the record of the joint meetings of the sub-groups on economic assessment, safeguarding, assessment of proliferation resistance, and alternative institutional arrangements, the matters arising from the sub-group reports and records, the special needs of less developed countries, the TCC meeting, 27-28 February 1979, and the future programme of work

76 FR 79754 - Twelfth Meeting: RTCA Special Committee 220, Automatic Flight Guidance and Control

Science.gov (United States)

2011-12-22

... technologies Administrative items (meeting schedule, location, and next meeting agenda) Any other business... 2 status--progress, issues and plan Review of WG 3 status--progress, issues and plans Review action.... Issued in Washington, DC, on December 15, 2011. Robert L. Bostiga, Manager, Business Operations Branch...

Evaluation of two new STR loci 9q2h2 and wg3f12 in a Japanese population.

Science.gov (United States)

Mizutani, M; Huang, X L; Tamaki, K; Yoshimoto, T; Uchihi, R; Yamamoto, T; Katsumata, Y; Armour, J A

1999-09-01

Two short tandem repeat (STR) loci (9q2h2 and wg3f12) have been evaluated in a Japanese population. Ten and seven different alleles were observed in 9q2h2 and wg3f12 respectively. 9q2h2 displayed simple polymorphism in tetrameric repeat structure; by contrast, wg3f12 contained variable numbers of tetrameric repeats and a 30-bp deletion/insertion polymorphism. No "interalleles" were found. The expected heterozygosities of 9q2h2 and wg3fl2 were 0.749 and 0.574, respectively. No deviation from Hardy-Weinberg equilibrium was found.

Non-exercise Estimation of V02max Using a Dichotomy of Meeting or Not Meeting DHHS Physical Activity Recommendations

Science.gov (United States)

Wier, Larry T.; Jackson, Allen W.; Jackson, Andrew S.

2009-01-01

The physical activity guidelines (PAG) established by the US Dept. of Health and Human Services in 2008 is consistent with a rating of >/= 6 on the 11-point NASA Physical Activity Status Scale (PASS). Wier, et. al. developed non-exercise models for estimating VO2(sub max) from a combination of PASS, age, gender and either waist girth (WG) (R = 0.810, SEE= 4.799 ml/kg/min), %Fat (R = 0. 817, SEE = 4.716 ml/kg/min) or BMI (R = 0.802, SEE = 4.900 ml . kg-1. min -1 ). PURPOSE: to develop non-exercise models to estimate VO2max from age, gender, body composition (WG, %Fat, BMI) and PASS dichotomized at meets or does not meet the PAG (PAG-PASS), and to compare the accuracy of the PAG-PASS models with the models using the 11-point PASS. METHODS: 2417 men and 384 women were measured for VO2max by indirect calorimetry (RER >1.1); age (yr), gender by M = 1, W = 0; WG at the umbilicus; %fat by skin-folds, BMI by weight (kg) divided by height squared (m 2 ) , and PAGPASS by PASS 6 = 1. RESULTS: Three models were developed by multiple regression to estimate VO2(sub max) from age, gender, PAG-PASS and either WG (R = 0.790, SEE=5.019 ml/kg/min), %FAT (R= 0.080, SEE = 4.915 ml/kg/min) or BMI (R = 0.777, SEE = 5.162ml/kg/min). Cross-validation by the PRESS technique confirmed these statistics. Simple correlations between measured VO2(sub max) and estimates from the PAG-PASS models with WG, %Fat and BMI were 0.790, 0.800 and 0.777, minimally different from the correlations obtained with the PASS models (0.810, 0.810, and 0.802). PAG-PASS and PASS model constant errors were also similar: 1 ml/kg/min for VO2(sub max) 50 ml/kg/min. CONCLUSIONS: Non-exercise models using the combined effects of age, gender, body composition and the dichotomized PAG-PASS provide estimates of VO2(sub max) that are accurate for most adults, and the accuracy of these models are similar to previously published models using the 11-point PASS.

Comments on INFCE/DEP./WG-4/100 by France

International Nuclear Information System (INIS)

1978-10-01

This document is a comment by the French delegation upon INFCE/DEP./WG-4/100. It expresses the French view that consideration of sub-national threats should be treated quite separately from questions of proliferation and that the methodology must also consider the possible proliferation strategies of governments relative to international commitments and safeguards systems

In vitro T lymphocyte responses to proteinase 3 (PR3) and linear peptides of PR3 in patients with Wegener's granulomatosis (WG)

NARCIS (Netherlands)

Van der Geld, YM; Huitema, MG; Franssen, CFM; Limburg, PC; Kallenberg, CGM; van der Zee, R.

2000-01-01

T cell-mediated immunity is thought to play an important role in the pathogenesis of WG. In previous studies a minority of WG patients as well as some healthy controls showed in vitro proliferation of their peripheral blood mononuclear cells (PBMC) to PR3, the main autoantigen in WG. The relevant

IEC-TC88WG8 testing of rotor blades

Energy Technology Data Exchange (ETDEWEB)

Delft, D R.V. van [Delft Univ. of Technology, STEVIN Lab., Delft (Netherlands)

1996-09-01

In 1994 the TC88 of IEC installed a working group (WG8) to draft a guideline on blade testing. This paper gives a description of the task of the working group. Furthermore it gives a report of the progress of the work and summarizes the possible contents of the working group document on blade testing. (au)

IEA SHC Task 42/ECES Annex 29 WG A1

DEFF Research Database (Denmark)

Ristić, Alenka; Furbo, Simon; Moser, Christoph

2016-01-01

An overview on the recent results on the engineering and characterization of sorption materials, PCMs and TCMs investigated in the working group WG A1 “Engineering and processing of TES materials” of IEA SHC Task 42 / ECES Annex 29 (Task 4229) entitled “Compact Thermal Energy Storage” is presented....

Application of SDSM and LARS-WG for simulating and downscaling of rainfall and temperature

Science.gov (United States)

Hassan, Zulkarnain; Shamsudin, Supiah; Harun, Sobri

2014-04-01

Climate change is believed to have significant impacts on the water basin and region, such as in a runoff and hydrological system. However, impact studies on the water basin and region are difficult, since general circulation models (GCMs), which are widely used to simulate future climate scenarios, do not provide reliable hours of daily series rainfall and temperature for hydrological modeling. There is a technique named as "downscaling techniques", which can derive reliable hour of daily series rainfall and temperature due to climate scenarios from the GCMs output. In this study, statistical downscaling models are used to generate the possible future values of local meteorological variables such as rainfall and temperature in the selected stations in Peninsular of Malaysia. The models are: (1) statistical downscaling model (SDSM) that utilized the regression models and stochastic weather generators and (2) Long Ashton research station weather generator (LARS-WG) that only utilized the stochastic weather generators. The LARS-WG and SDSM models obviously are feasible methods to be used as tools in quantifying effects of climate change condition in a local scale. SDSM yields a better performance compared to LARS-WG, except SDSM is slightly underestimated for the wet and dry spell lengths. Although both models do not provide identical results, the time series generated by both methods indicate a general increasing trend in the mean daily temperature values. Meanwhile, the trend of the daily rainfall is not similar to each other, with SDSM giving a relatively higher change of annual rainfall compared to LARS-WG.

Non-exercise Estimation of V02max Using a Dichotomy of Meeting or Not Meeting DHHS Physical Activity Recommendations

Science.gov (United States)

Wier, Larry T.; Jackson, Allen W.; Jackson, Andrew S.

2009-01-01

The physical activity guidelines (PAG) established by the US Dept. of Health and Human Services in 2008 is consistent with a rating of >/= 6 on the 11-point NASA Physical Activity Status Scale (PASS). Wier, et. al. developed non-exercise models for estimating VO2(sub max) from a combination of PASS, age, gender and either waist girth (WG) (R = 0.810, SEE= 4.799 ml/kg/min), %Fat (R = 0. 817, SEE = 4.716 ml/kg/min) or BMI (R = 0.802, SEE = 4.900 ml . kg-1. min -1 ). PURPOSE: to develop non-exercise models to estimate VO2max from age, gender, body composition (WG, %Fat, BMI) and PASS dichotomized at meets or does not meet the PAG (PAG-PASS), and to compare the accuracy of the PAG-PASS models with the models using the 11-point PASS. METHODS: 2417 men and 384 women were measured for VO2max by indirect calorimetry (RER >1.1); age (yr), gender by M = 1, W = 0; WG at the umbilicus; %fat by skin-folds, BMI by weight (kg) divided by height squared (m 2 ) , and PAGPASS by PASS 6 = 1. RESULTS: Three models were developed by multiple regression to estimate VO2(sub max) from age, gender, PAG-PASS and either WG (R = 0.790, SEE=5.019 ml/kg/min), %FAT (R= 0.080, SEE = 4.915 ml/kg/min) or BMI (R = 0.777, SEE = 5.162ml/kg/min). Cross-validation by the PRESS technique confirmed these statistics. Simple correlations between measured VO2(sub max) and estimates from the PAG-PASS models with WG, %Fat and BMI were 0.790, 0.800 and 0.777, minimally different from the correlations obtained with the PASS models (0.810, 0.810, and 0.802). PAG-PASS and PASS model constant errors were also similar: gender, PASS and for VO2(sub max) between 30 and 50 ml/kg/min (70% of the sample) but > 1 ml/kg/min for VO2(sub max) 50 ml/kg/min. CONCLUSIONS: Non-exercise models using the combined effects of age, gender, body composition and the dichotomized PAG-PASS provide estimates of VO2(sub max) that are accurate for most adults, and the accuracy of these models are similar to previously published models using

10 CFR 72.34 - Environmental report.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Environmental report. 72.34 Section 72.34 Energy NUCLEAR..., and Contents § 72.34 Environmental report. Each application for an ISFSI or MRS license under this part must be accompanied by an Environmental Report which meets the requirements of subpart A of part...

Wind turbine certification - the committee draft by IEC-TC88-WG9

Energy Technology Data Exchange (ETDEWEB)

Hauge Madsen, P [Risoe National Lab., Wind Energy and Atmospheric Physics Dept., Roskilde (Denmark)

1999-03-01

In 1995 the Technical Committee TC88 of the International Electrotechnical Commission decided to start a new work item, namely to prepare a standard for the certification procedures for wind turbines with respect to safety, performance, interaction with the public grid, environmental requirements and the documentation requested by the certification bodies. The purpose was to provide a common basis for certification of wind turbines, including a basis for accreditation of certification bodies and mutual recognition of certificates. A working group (WG9) was created to prepare a committee draft. WG9 submitted the result late in 1998 to TC88. This paper presents the committee draft Standard, which defines a certification system for Wind Turbine Generator Systems. Key issues in the evaluation of conformity with these standards and identified needs for other technical criteria and procedures are presented. (au) 10 refs.

Progress in digital color workflow understanding in the International Color Consortium (ICC) Workflow WG

Science.gov (United States)

McCarthy, Ann

2006-01-01

The ICC Workflow WG serves as the bridge between ICC color management technologies and use of those technologies in real world color production applications. ICC color management is applicable to and is used in a wide range of color systems, from highly specialized digital cinema color special effects to high volume publications printing to home photography. The ICC Workflow WG works to align ICC technologies so that the color management needs of these diverse use case systems are addressed in an open, platform independent manner. This report provides a high level summary of the ICC Workflow WG objectives and work to date, focusing on the ways in which workflow can impact image quality and color systems performance. The 'ICC Workflow Primitives' and 'ICC Workflow Patterns and Dimensions' workflow models are covered in some detail. Consider the questions, "How much of dissatisfaction with color management today is the result of 'the wrong color transformation at the wrong time' and 'I can't get to the right conversion at the right point in my work process'?" Put another way, consider how image quality through a workflow can be negatively affected when the coordination and control level of the color management system is not sufficient.

77 FR 56254 - 89th Meeting: RTCA Special Committee 159, Global Positioning Systems (GPS)

Science.gov (United States)

2012-09-12

... held March 16, 2012. Review Working Group (WG) Progress and Identify Issues for Resolution. GPS/3nd... Standards for Global Positioning System/Wide Area Augmentation System Airborne Equipment Assignment/Review of Future Work. Other Business. Date and Place of Next Meeting. Adjourn Attendance is open to the...

Improving quality in the preanalytical phase through innovation, on behalf of the European Federation for Clinical Chemistry and Laboratory Medicine (EFLM) Working Group for Preanalytical Phase (WG-PRE)

DEFF Research Database (Denmark)

Lippi, Giuseppe; Baird, Geoffrey S.; Banfi, Giuseppe

2017-01-01

process remain, especially in the preanalytical phase ranging from test ordering to obtaining and managing the biological specimens. The Working Group for the Preanalytical Phase (WG-PRE) of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) has planned many activities aimed...... at mitigating the vulnerability of the preanalytical phase, including the organization of three European meetings in the past 7 years. Hence, this collective article follows the previous three opinion papers that were published by the EFLM WGPRE on the same topic, and brings together the summaries...

78 FR 20167 - 33rd Meeting: RTCA Special Committee 206, Aeronautical Information and Meteorological Data Link...

Science.gov (United States)

2013-04-03

... Other Business Sub-Groups meetings Break out, as necessary daily EDR Turbulence Standards Project Briefing from FAA SE2020 Team SG6 WG1 Architecture and MASPS presentations SG3 AIS and MET Services Delivery Architecture Recommendations Document Review (FRAC release approval). Closing Plenary--Sub-Groups...

Evaluation of the Performance of ClimGen and LARS-WG models in generating rainfall and temperature time series in rainfed research station of Sisab, Northern Khorasan

Directory of Open Access Journals (Sweden)

najmeh khalili

2016-10-01

Full Text Available Introduction:Many existing results on water and agriculture researches require long-term statistical climate data, while practically; the available collected data in synoptic stations are quite short. Therefore, the required daily climate data should be generated based on the limited available data. For this purpose, weather generators can be used to enlarge the data length. Among the common weather generators, two models are more common: LARS-WG and ClimGen. Different studies have shown that these two models have different results in different regions and climates. Therefore, the output results of these two methods should be validated based on the climate and weather conditions of the study region. Materials and Methods:The Sisab station is 35 KM away from Bojnord city in Northern Khorasan. This station was established in 1366 and afterwards, the meteorological data including precipitation data are regularly collected. Geographical coordination of this station is 37º 25׳ N and 57º 38׳ E, and the elevation is 1359 meter. The climate in this region is dry and cold under Emberge and semi-dry under Demarton Methods. In this research, LARG-WG model, version 5.5, and ClimGen model, version 4.4, were used to generate 500 data sample for precipitation and temperature time series. The performance of these two models, were evaluated using RMSE, MAE, and CD over the 30 years collected data and their corresponding generated data. Also, to compare the statistical similarity of the generated data with the collected data, t-student, F, and X2 tests were used. With these tests, the similarity of 16 statistical characteristics of the generated data and the collected data has been investigated in the level of confidence 95%. Results and Discussion:This study showed that LARS-WG model can better generate precipitation data in terms of statistical error criteria. RMSE and MAE for the generated data by LAR-WG were less than ClimGen model while the CD value of

Legal requirements on the arrangement of the selection procedure for the authorisation of power concession and natural gas concession according to paragraph 46 EnWG; Rechtliche Anforderungen an die Ausgestaltung der Auswahlverfahren zur Vergabe von Strom- und Gaskonzessionen nach paragraph 46 EnWG

Energy Technology Data Exchange (ETDEWEB)

Fischer, Henning; Embacher, Patrick [Roedl und Partner GbR, Koeln (Germany); Wolf, Thomas [Roedl und Partner GbR, Nuernberg (Germany)

2012-08-15

By the Act on Redefining the energy industry regulations, on 26th July, 2011 the Federal Legislature has made extensive changes and amendments to the Energy Economy Law (EnWG). The aim of the paragraph 1 section 1 EnWG is the requirement that the power supply must be safe, affordable, user-friendly, efficient and environmentally safe for the general public. From paragraph 2 arise the objectives of ensuring effective and undistorted competition in the energy supply and the long-term performance and reliable operation of power distribution systems. The economic interests of local communities are not explicitly mentioned.

TRENT2D WG: a smart web infrastructure for debris-flow modelling and hazard assessment

Science.gov (United States)

Zorzi, Nadia; Rosatti, Giorgio; Zugliani, Daniel; Rizzi, Alessandro; Piffer, Stefano

2016-04-01

Mountain regions are naturally exposed to geomorphic flows, which involve large amounts of sediments and induce significant morphological modifications. The physical complexity of this class of phenomena represents a challenging issue for modelling, leading to elaborate theoretical frameworks and sophisticated numerical techniques. In general, geomorphic-flows models proved to be valid tools in hazard assessment and management. However, model complexity seems to represent one of the main obstacles to the diffusion of advanced modelling tools between practitioners and stakeholders, although the UE Flood Directive (2007/60/EC) requires risk management and assessment to be based on "best practices and best available technologies". Furthermore, several cutting-edge models are not particularly user-friendly and multiple stand-alone software are needed to pre- and post-process modelling data. For all these reasons, users often resort to quicker and rougher approaches, leading possibly to unreliable results. Therefore, some effort seems to be necessary to overcome these drawbacks, with the purpose of supporting and encouraging a widespread diffusion of the most reliable, although sophisticated, modelling tools. With this aim, this work presents TRENT2D WG, a new smart modelling solution for the state-of-the-art model TRENT2D (Armanini et al., 2009, Rosatti and Begnudelli, 2013), which simulates debris flows and hyperconcentrated flows adopting a two-phase description over a mobile bed. TRENT2D WG is a web infrastructure joining advantages offered by the software-delivering model SaaS (Software as a Service) and by WebGIS technology and hosting a complete and user-friendly working environment for modelling. In order to develop TRENT2D WG, the model TRENT2D was converted into a service and exposed on a cloud server, transferring computational burdens from the user hardware to a high-performing server and reducing computational time. Then, the system was equipped with an

The competitive concession assignment according to paragraph 46 EnWG. Procedure without rules and arbitrators; Die wettbewerbliche Vergabe von Konzessionen nach paragraph 46 EnWG. Verfahren ohne Regeln und Schiedsrichter?

Energy Technology Data Exchange (ETDEWEB)

Schau, Goetz-Friedrich [Niedersaechsisches Ministerium fuer Wirtschaft, Arbeit und Verkehr, Hannover (Germany). Landeskartellbehoerde

2011-01-15

Presently, the concession assignment regarding to paragraph 46 EnWG (Energy Economy Law) has a great practical significance. For the first time, the concession assignment proceeds in the background of the liberalized and regulated electricity and natural gas markets. The half-hearted legal obligation to the competition of concession as well as the so far dormant supervisory authorities result in a substantial juridical insecurity in the process at the expense of the competitor.

77 FR 14584 - Eleventh Meeting: RTCA Special Committee 217, Joint With EUROCAE Working Group-44, Terrain and...

Science.gov (United States)

2012-03-12

... Modeling Effort for Terrain and Obstacles within the Committee [ssquf] Decided on a method for addressing the use of the term ``obstacle'' in DO-276 and ``vertical structure'' in DO-272. [ssquf] Determine if... Meeting Adjourn Attendance is open to the interested public but limited to space availability. With the...

Information about AER WG A on improvement, extension and validation of parametrized few-group libraries for VVER 440 and VVER 1000

International Nuclear Information System (INIS)

Mikolas, P.

2010-01-01

Joint AER Working Group A on 'Improvement, extension and validation of parameterized few-group libraries for WWER-440 and WWER-1000' and AER Working Group B on 'Core design' nineteenth meeting was hosted by VUJE a. s. in Modra - Harmonia (Slovakia) during the period of 20. to 22. April 2010. There were present altogether 12 participants from 8 member organizations and 9 papers were presented (8 of them in written form). Objectives of the meeting of WG A are: Issues connected with spectral calculations and few-groups libraries preparation, their accuracy and validation. Presentations were devoted to some aspects of transport and diffusion calculations and to the benchmark dealing with WWER-1000 core periphery power tilt. Tamas Parko (co-authors Istvan Pos and Sandor Patai Szabo) described in his presentation 'Application of Discontinuity factors in C-PORCA 7 code', Radoslav Zajac (co-authors Petr Darilek and Vladimir Necas) spoke about 'Fast Reactor Nodalisation in HELIOS Code', Gabriel Farkas presented 'Calculation of Spatial Weighting Functions of Ex-Core Neutron Detectors for WWER-440 Using Monte Carlo Approach' and Daniel Sprinzl (co-authors Vaclav Krysl, Pavel Mikolas and Jiri Svarny) provided a definition of a benchmark in ' 'MIDICORE' WWER-1000 core periphery power tilt benchmark proposal'. (Author)

Information about AER WG a on improvement, extension and validation of parametrized few-group libraries for VVER 440 and VVER 1000

International Nuclear Information System (INIS)

Mikolas, P.

2009-01-01

Joint AER Working Group A on 'Improvement, extension and validation of parameterized few-group libraries for VVER-440 and VVER-1000' and AER Working group B on 'Core design' eighteenth meeting was hosted by Skoda JS a.s. in Plzen (Czech Republic) during the period of 4 to 6 May 2009. There were present altogether 16 participants from 6 member organizations and 13 presentations were read. Objectives of the meeting of WG A are: Issues connected with spectral calculations and few-groups libraries preparation, their accuracy and validation. Presentations were devoted to some aspects of few group libraries preparations and to the benchmark dealing with VVER-440 follower modeling in calculations. Gy. Hegyi gave some new information about NURESIM-NURISP EU project (ZR-6), R. Zajac spoke about the development of data libraries for codes BIPR-7 and PERMAK, P. Darilek compared FA's with Gd during burning process and Yu. Bilodid described further development of plutonium-based burnup history modeling in DYN3D burnup calculations. G. Hordosy presented results of control rod follower induced local power peaking computational benchmark and J. Svarny described Monte Carlo VVER-440 control rod follower benchmark computations. Future activities are also shortly described in the end of the paper. (author)

The Optimal Culture Conditions of Bacterium Vibrio harveyi WG1702 from Clam Meretrix meretrix%哈氏弧菌文蛤分离株WG1702培养条件优化研究

Institute of Scientific and Technical Information of China (English)

刘连生; 闫茂仓; 赵海泉; 陈倩影; 马爱敏; 林志华

2010-01-01

于2007年9月在江苏吕泗文蛤发病高峰期,从发病文蛤体内和养殖水体中分离到1株哈氏弧菌 WG1702,培养条件优化试验结果表明,菌株WG1702在32 h时达到生长高峰,最适温度为28 ℃,最佳初始pH为7,最佳盐度为40,最佳装液量为60 ml/150 ml,促进生长的金属离子是NH_4~+、Fe~(2+) 、Fe~(3+) ,最佳C、N源为葡萄糖和蛋白胨;pH、温度、不同菌龄正交试验证明最佳组合为pH 7.11,温度28 ℃,菌龄24 h,通过方差分析结果可以看出三因素中pH对生长影响显著( P ＜0.05).

Transmission contracts and procurement law. Applicability of the instructions of the procurement law to the selection procedure in the connection with the conclusion of transmission contracts according to paragraph 46 EnWG?; Konzessionsvertraege und Vergaberecht. Anwendbarkeit der Vorschriften ueber das Vergaberecht auf das Auswahlverfahren beim Abschluss von Wegenutzungsvertraegen nach paragraph 46 EnWG?

Energy Technology Data Exchange (ETDEWEB)

Niehof, Roland

2011-01-15

The conclusion of transmission contracts between the municipalities and the operators of supply lines (electricity, natural gas) is regulated by law. paragraph 46 of the Energy Economy Law (EnWG) describes the requirements concerning the selection a power supply company and concerning the procedure to be followed. The contribution under consideration examines whether the regulations of the procurement right can be applied directly or similarly beside paragraph 46 EnWG to the conclusion of transmission contracts. The author of the contribution under consideration deals with the newer jurisdiction of the European Court of Justice.

Assessment of acute toxicity of thiamethoxam (Actara® 25WG to Achatina fulica and its potential ecological applications

Directory of Open Access Journals (Sweden)

Maria Kim Feliz N. Abog

2012-12-01

Full Text Available Achatina fulica is considered as one of the world’s worst invasive species and is known to cause ecological disruption as well as agricultural and health problems in the Philippines. The study evaluated the use of the insecticide thiamethoxam (Actara® 25WG in the control of A. fulica populations. This was done by performing an acute toxicity test of thiamethoxam to A. fulica. Six individuals each were exposedto thiamethoxam concentrations of 0, 50, 100, 200, and 400 μg/L for 72 hours. The percent mortality was then determined after the exposure period. Probit analysis was used to determine the LD50 of thiamethoxam to A. fulica. The LD50 was found to be 662.95 ± 172.98 μg/L. Using the mean body weight of the snails, the LD50 per body weight of A. fulica was determined to be 90.09 ± 23.60 μg/kg. This is 70 times lower than the recommended application of thiamethoxam on field. Thus, normal application would eliminate A. fulica. However, because the LD50 to A. fulica is higher than that for other beneficial non-target species such as honey bees (0.03 μg/bee, the use of thiamethoxam in the control of A. fulica populations is only recommended when in conjunction with the control of target pest insects.

Key points of the new KrWG (German Waste Management and Recycling Act); Eckpunkte des neuen Kreislaufwirtschaftsgesetzes

Energy Technology Data Exchange (ETDEWEB)

Petersen, Frank [Bundesministerium fuer Umwelt, Naturschutz und Reaktorsicherheit, Bonn (Germany)

2012-11-01

With the new KrWG, the EU Waste Framework Directive (2008/98/EG, AbfRRL) is implemented in German law, and the existing German waste management law is modified quite extensively. The new law focuses on sustainable improvement of environmental protection, climate protection and resources efficiency in waste management by stressing prevention of wasting and recycling of waste materials. At the same time, practicable application with legal compliance is to be facilitated by implementing concepts and definitions from EU law and by defining central regulations more precisely. This will also help to do away with excessive bureaucracy and to make regulations easier to implement. (orig.) [German] Mit dem neuen Kreislaufwirtschaftsgesetz (KrWG) wird die EU-Abfallrahmenrichtlinie (Richtlinie 2008/98/EG, AbfRRL) in deutsches Recht umgesetzt und das bestehende deutsche Abfallrecht umfassend modernisiert. Ziel des neuen Gesetzes ist eine nachhaltige Verbesserung des Umwelt- und Klimaschutzes sowie der Ressourceneffizienz in der Abfallwirschaft durch Staerkung der Abfallvermeidung und des Recyclings von Abfaellen. Gleichzeitig soll durch die Uebernahme EU-rechtlicher Begriffe und Definitionen sowie die Praezisierung zentraler Regelungen die praktikable und rechtssichere Anwendung des Gesetzes erleichtert werden. Zudem werden unnoetige Buerokratielasten abgebaut und verschiedene Regelungen vollzugstauglicher ausgestaltet. (orig.)

Probabilistic Robustness Analysis of Timber Structures—Results from EU COST Action E55:WG3

DEFF Research Database (Denmark)

Kirkegaard, Poul Henning; Sørensen, John Dalsgaard

2011-01-01

The present paper outlines results from Working Group 3 (WG3) in the EU COST Action E55—‘Modelling of the performance of timber structures’. The objectives of the project are related to the three main research activities: the identification and modelling of relevant load and environmental exposure...... scenarios, the improvement of knowledge concerning the behaviour of timber structural elements and the development of a generic framework for the assessment of the life-cycle vulnerability and robustness of timber structures....

IAEA technical meeting on fissile material strategies for sustainable nuclear energy

International Nuclear Information System (INIS)

Ganguly, Chaitanyamoy; Koyama, Kazutoshi

2005-01-01

A Technical Meeting (TM) on 'Fissile Material Management Strategies for Sustainable Nuclear Energy' was organized by the International Atomic Energy Agency (IAEA) in Vienna from 12 to 15 September 2005. Prior to the TM, three Working Groups (WG) composed of experts from 10 countries prepared Key Issues papers on: 1) Uranium Demand and Supply through 2050; 2) Back-end Fuel Cycle Options; and 3) Sustainable Nuclear Energy beyond 2050: Cross-cutting Issues. Some 36 papers, including 3 key issue papers, were presented during the TM in 3 different sessions. The present paper summarizes the deliberations of the TM. (author)

Production of selenium-72 and arsenic-72

Science.gov (United States)

Phillips, D.R.

1994-12-06

Methods and apparatus are described for producing selenium-72, separating it from its daughter isotope arsenic-72, and generating multiple portions of a solution containing arsenic-72 from a reusable parent substance comprised of selenium-72. The invention provides apparatus which can be located at a site where arsenic-72 is used, for purposes such as PET imaging, to produce arsenic-72 as needed, since the half-life of arsenic-72 is very short. 2 figures.

DEGRADATION AND DEBITTERING OF A TRYPTIC DIGEST FROM BETA-CASEIN BY AMINOPEPTIDASE-N FROM LACTOCOCCUS-LACTIS SUBSP CREMORIS WG2

NARCIS (Netherlands)

TAN, PST; VANKESSEL, TAJM; VANDEVEERDONK, FLM; ZUURENDONK, PF; BRUINS, AP; KONINGS, WN

The mode of action of purified aminopeptidase N from Lactococcus lactis subsp. cremoris Wg2 on a complex peptide mixture of a tryptic digest from bovine beta-casein was analyzed. The oligopeptides produced in the tryptic digest before and after aminopeptidase N treatment were identified by analysis

Mapping out Patience: Cartography, Cinema and W.G. Sebald

Directory of Open Access Journals (Sweden)

Taien Ng-Chan

2015-10-01

Full Text Available Cinematic cartography can be an especially powerful tool for deep mapping, as it can convey the narratives, emotions, memories and histories, as well as the locations and geography that are associated with a place. This is evident in the documentary film Patience (After Sebald by Grant Gee, which follows in the footsteps of W.G. Sebald and his walking tour of Suffolk, England, as described in his book The Rings of Saturn. A variety of strategies in cinematic cartography are used quite consciously in Gee’s exploration of space, place and story. Using Teresa Castro’s three cartographic shapes of cinema, I structure an analysis of the film’s opening scene through a discussion of cinematic cartography, or the plotting of geospatial data onto a map, as well as what I will differentiate as cartographic cinema, or the mapping of space through the cinematographic image. I argue that both are necessary not only to have a deep understanding of the world and our place in it, but also in how to transmit that knowledge to others.

45 CFR 264.72 - What requirements are imposed on a State if it receives contingency funds?

Science.gov (United States)

2010-10-01

... receives contingency funds? 264.72 Section 264.72 Public Welfare Regulations Relating to Public Welfare... Contingency Fund? § 264.72 What requirements are imposed on a State if it receives contingency funds? (a)(1) A State must meet a Contingency Fund MOE level of 100 percent of historic State expenditures for FY 1994...

Editorial: Hybrid Systems

DEFF Research Database (Denmark)

Olderog, Ernst-Rüdiger; Ravn, Anders Peter

2007-01-01

An introduction to three papers in a special issue on Hybrid Systems. These paper were first presented at an IFIP WG 2.2 meeting in Skagen 2005.......An introduction to three papers in a special issue on Hybrid Systems. These paper were first presented at an IFIP WG 2.2 meeting in Skagen 2005....

Cartography of memory in Chris Marker and W.G. Sebald: Notes about History, memory and maps

Directory of Open Access Journals (Sweden)

Álvaro Brito

2017-01-01

Full Text Available This paper aims to approach the artists Chris Marker and W.G. Sebald, trying to determine and develop pervasive questions in their works: the construction of a historiographic discourse, the ambiguities of memory, the erratic movement of their characters and essayistic thinking. We have tried to draft some starting points to make possible the writing of a memory as a cartography, created through walking on the world and also through the collection of images and of stories that tell about lives that went astray in the mis-paths of History.

Total dietary fiber intakes in the US population are related to whole grain consumption: results from the National Health and Nutrition Examination Survey 2009 to 2010.

Science.gov (United States)

Reicks, Marla; Jonnalagadda, Satya; Albertson, Ann M; Joshi, Nandan

2014-03-01

Whole grain (WG) foods have been shown to reduce chronic disease risk and overweight. Total dietary fiber is associated with WG and its health benefits. The purpose was to determine whether associations exist between WG intake (no-WG intake, 0 ounce equivalent [oz eq]; low, >0-cereals and yeast breads/rolls in the high WG intake group compared with the no-WG intake group. Major WG sources for children/adolescents and adults included yeast bread/rolls (24% and 27%, respectively), RTE cereals (25% and 20%, respectively), and oatmeal (12% and 21%, respectively). Among those with the highest WG intake, WG RTE cereal with no added bran was the greatest contributor to total dietary fiber compared with other RTE cereal types. Whole grain foods make a substantial contribution to total dietary fiber intake and should be promoted to meet recommendations. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

Intercomparison of Dosimeters for Non-Target Organ Dose Measurements in Radiotherapy - Activity of EURADOS WG 9: Radiation Protection in Medicine

International Nuclear Information System (INIS)

Miljanic, S.; Knezevic, Z.; Bessieres, I.; Bordy, J.-M.; D'Agostino, E.; d'Errico, F.; di Fulvio, A.; Domingo, C.; Olko, P.; Stolarczyk; Silari, M.; Harrison, R.

2011-01-01

It has been known for a long time that patients treated with ionizing radiation carry a risk of developing radiation induced cancer in their lifetimes. It is recognized that cure/survival rates in radiotherapy are increasing, but so are secondary cancers. These occurrences are amplified by the early detection of disease in younger patients. These patients are cured from the primary disease and have long life-expectancies, which increase their chances of developing secondary malignancies. The motivation of the EURADOS Working Group 9 (WG 9) ''Radiation protection dosimetry in medicine'' is to assess undue non-target patient doses in radiotherapy and the related risks of secondary malignancy with the most accredited available methods and with the emphasis on a thorough evaluation of dosimetry methods for the measurements of doses remote from the target volume, in phantom experiments. The development of a unified and comprehensive dosimetry methodology for non-target dose estimation is the key element of the WG9 current work. The first scientific aim is to select and review dosimeters suitable for photon and neutron dosimetry in radiotherapy and to evaluate the characteristics of dosimeters at CEA LIST Saclay in reference clinical LINAC beam. (author)

Contrasting association of a non-synonymous leptin receptor gene polymorphism with Wegener's granulomatosis and Churg-Strauss syndrome.

Science.gov (United States)

Wieczorek, Stefan; Holle, Julia U; Bremer, Jan P; Wibisono, David; Moosig, Frank; Fricke, Harald; Assmann, Gunter; Harper, Lorraine; Arning, Larissa; Gross, Wolfgang L; Epplen, Joerg T

2010-05-01

There is evidence that the leptin/ghrelin system is involved in T-cell regulation and plays a role in (auto)immune disorders such as SLE, RA and ANCA-associated vasculitides (AAVs). Here, we evaluate the genetic background of this system in WG. We screened variations in the genes encoding leptin, ghrelin and their receptors, the leptin receptor (LEPR) and the growth hormone secretagogue receptor (GHSR). Three single nucleotide polymorphisms (SNPs) in each gene region were analysed in 460 German WG cases and 878 ethnically matched healthy controls. A three-SNP haplotype of GHSR was significantly associated with WG [P = 0.0067; corrected P-value (P(c)) = 0.026; odds ratio (OR) = 1.30; 95% CI 1.08, 1.57], as was one non-synonymous SNP in LEPR (Lys656Asn, P = 0.0034; P(c) = 0.013; OR = 0.72; 95% CI 0.58, 0.90). These four SNPs were re-analysed in independent cohorts of 226 German WG cases and 519 controls. While the GHSR association was not confirmed, allele frequencies of the LEPR SNP were virtually identical to those from the initial cohorts. Analysis of this SNP in the combined WG and control panels revealed a significant association of the LEPR 656Lys allele with WG (P = 0.00032; P(c) = 0.0013; OR = 0.72; 95% CI 0.60, 0.86). Remarkably, the Lys656Asn SNP showed contrasting allele distribution in two cohorts of 108 and 88 German cases diagnosed with Churg-Strauss syndrome (CSS, combined P = 0.0067; OR = 1.41; 95% CI 1.10, 1.81), whereas identical allele frequencies were revealed when comparing British WG and microscopic polyangiitis cases. While GHSR has to be further evaluated, these data provide profound evidence for an association of the LEPR Lys656Asn SNP with AAV, resulting in opposing effects in WG and CSS.

THE PECULIAR PHOTOMETRIC PROPERTIES OF 2010 WG9: A SLOWLY ROTATING TRANS-NEPTUNIAN OBJECT FROM THE OORT CLOUD

Energy Technology Data Exchange (ETDEWEB)

Rabinowitz, David; Schwamb, Megan E.; Hadjiyska, Elena [Center for Astronomy and Astrophysics, Yale University, New Haven, CT (United States); Tourtellotte, Suzanne [Astronomy Department, Yale University, New Haven, CT (United States); Rojo, Patricio [Department of Astronomy, University of Chile, Santiago (Chile)

2013-07-01

We present long-term BVRI observations of 2010 WG9, an {approx}100 km diameter trans-Neptunian object (TNO) with an extremely high inclination of 70 Degree-Sign discovered by the La Silla-QUEST southern sky survey. Most of the observations were obtained with ANDICAM on the SMARTS 1.3 m at Cerro Tololo, Chile from 2010 December to 2012 November. Additional observations were made with EFOSC2 on the 3.5 m NTT telescope of the European Southern Observatory at La Silla, Chile in 2011 February. The observations reveal a sinusoidal light curve with amplitude 0.14 mag and period 5.4955 {+-} 0.0025 days, which is likely half the true rotation period. Such long rotation periods have previously been observed only for tidally evolved binary TNOs, suggesting that 2010 WG9 may be such a system. We predict a nominal separation of at least 790 km, resolvable with the Hubble Space Telescope and ground-based systems. We measure B - R = 1.318 {+-} 0.029 and V - R = 0.520 {+-} 0.018, consistent with the colors of modestly red Centaurs and Damocloids. At I-band wavelengths, we observe an unusually large variation of color with rotational phase, with R - I ranging from 0.394 {+-} 0.025 to 0.571 {+-} 0.044. We also measure an absolute R-band absolute magnitude of 7.93 {+-} 0.05 and solar phase coefficient of 0.049 {+-} 0.019 mag deg{sup -1}.

Collaborative networks in the internet of services: 13th IFIP WG 5.5 working conference on virtual enterprises, PRO-VE 2012, Bournemouth, UK, October 2012: proceedings

NARCIS (Netherlands)

Camarinha-Matos, L.M.; Xu, L.; Afsarmanesh, H.

2012-01-01

This book constitutes the refereed proceedings of the 13th IFIP WG 5.5 Working Conference on Virtual Enterprises, PRO-VE 2012, held in Bournemouth, UK, in October 2012. The 61 revised papers presented were carefully selected from numerous submissions. They provide a comprehensive overview of

News from the Biological Stain Commission no. 12

DEFF Research Database (Denmark)

Lyon, H O

2012-01-01

In this 12(th) issue of News from the Biological Stain Commission (BSC) under the heading of Regulatory affairs, the Biological Stain Commission's International Affairs Committee presents information from the meetings of ISO/TC 212/WG 1 Quality and competence in the medical laboratory and ISO....../TC 212/WG 3 In vitro diagnostic products both held on 2 - 3 June 2010, plus information on the second plenary meeting of ISO/TC 212 Clinical laboratory testing and in vitro diagnostic test systems held on 4 June 2010. All meetings took place in Seoul, Republic of Korea. Finally, information is provided...

Earthworms in Short-term Contact with a Low Dose of Neonicotinoid Actara 25WG

Directory of Open Access Journals (Sweden)

Mariola Garczyńska

2018-05-01

Full Text Available A laboratory experiment, carried out for five months, was designed to assess effects produced by the neonicotinoid Actara 25 WG, used at a dose recommended by the manufacturer, in the dynamics of populations of epigeic earthworms Eisenia fetida (Sav. and Dendrobena veneta (Rosa. The study was conducted in a climatic chamber and involved balanced biomass of mature specimens representing both species, in 3 replications of soil medium with the insecticide, in addition to controls. The growing populations were inspected five times, by means of manual segregation of the substrate. The insecticide led to an increase in both the number of specimens and biomass of E. fetida population (overall as well as mature and immature worms, yet it reduced their reproduction (decreased number of cocoons (p<0.05. In the case of D.veneta, the neonicotinoid insecticide produced positive effects only in mature specimens (p<0.05.

Policy revision in health enterprise information security: P3WG final report

Science.gov (United States)

Sostrom, Kristen; Collmann, Jeff R.

2003-05-01

Health information management policies usually address the use of paper records with little or no mention of electronic health records. Information Technology (IT) policies often ignore the health care business needs and operational use of the information stored in its systems. Representatives from the Telemedicine & Advanced Technology Research Center (TATRC), TRICARE and Offices of the Surgeon General of each Military Service, collectively referred to as the Policies, Procedures and Practices Work Group (P3WG) examined military policies and regulations relating to computer-based information systems and medical records management. Using an interdisciplinary and interservice QA approach they compared existing military policies with the Health Insurance Portability and Accountability Act (HIPAA) Security Rule to identify gaps and discrepancies. The final report, including a plain English explanation of the individual standards and relevance to the Department of Defense (DoD), a comparative analysis and recommendations, will feed in to the security management process and HIPAA implementation efforts at multiple levels within the DoD. In light of High Reliability Theory, this process models how large enterprises may coordinate policy revision and reform across broad organizational and work domains, building consensus on key policy reforms among military stakeholders across different disciplines, levels of command hierarchy and services.

Effect of plant resistance and BioAct WG (Purpureocillium lilacinum strain 251) on Meloidogyne incognita in a tomato-cucumber rotation in a greenhouse.

Science.gov (United States)

Giné, Ariadna; Sorribas, Francisco J

2017-05-01

The effectiveness of combining resistant tomato with BioAct WG (Purpureocillium lilacinum strain 251, Pl251) against Meloidogyne incognita was assessed in a tomato-cucumber rotation in a greenhouse over 2 years. Additionally, the enzymatic activity of the fungus, the percentage of fungal egg and juvenile parasitism, cardinal temperatures and the effect of water potential on mycelial growth and the soil receptivity to Pl251 were determined in vitro. Plant resistance was the only factor that suppressed nematode and crop yield losses. Percentage of egg parasitism in plots treated with BioAct WG was less than 2.6%. However, under in vitro conditions, Pl251 showed protease, lipase and chitinase activities and parasitised 94.5% of eggs, but no juveniles. Cardinal temperatures were 14.2, 24-26 and 35.4 °C. The maximum Pl251 mycelial growth was at -0.25 MPa and 25 °C. Soil temperatures and water potential in the greenhouse were in the range of the fungus. However, soil receptivity was lower in greenhouse soil, irrespective of sterilisation, than in sterilised sand. Plant resistance was the only factor able to suppress nematode densities, disease severity and yield losses, and to protect the following cucumber crop. Environmental factors involved in soil receptivity could have negatively affected fungus effectiveness. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

SE-72/AS-72 generator system based on Se extraction/ As reextraction

Science.gov (United States)

Fassbender, Michael Ernst; Ballard, Beau D

2013-09-10

The preparation of a .sup.72Se/.sup.72As radioisotope generator involves forming an acidic aqueous solution of an irradiated alkali bromide target such as a NaBr target, oxidizing soluble bromide in the solution to elemental bromine, removing the elemental bromine, evaporating the resulting solution to a residue, removing hydrogen chloride from the residue, forming an acidic aqueous solution of the residue, adding a chelator that selectively forms a chelation complex with selenium, and extracting the chelation complex from the acidic aqueous solution into an organic phase. As the .sup.72Se generates .sup.72As in the organic phase, the .sup.72As may be extracted repeatedly from the organic phase with an aqueous acid solution.

MDEP AP1000WG Design-Specific Common Position CP-AP1000WG-02. Common position addressing Fukushima Daiichi NPP accident-related issues

International Nuclear Information System (INIS)

2016-09-01

A severe accident involving several units took place in Japan at Fukushima Daiichi nuclear power plant (NPP) in March 2011. The immediate cause of the accident was an earthquake followed by a tsunami coupled with inadequate provisions against the consequences of such events in the design. Opportunities to improve protection against a realistic design basis tsunami had not been taken. As a consequence of the tsunami, safety equipment and the related safety functions were lost at the plant, leading to core damage in three units and subsequently to large radioactive release. Several studies have already been performed to better understand the accident progression and detailed technical studies are still in progress in Japan and elsewhere. In the meantime, on-going studies on the behaviour of nuclear power plants in very severe situations, similar to Fukushima Daiichi, seek to identify potential vulnerabilities in plant design and operation; to suggest reasonably practicable upgrades; or to recommend enhanced regulatory requirements and guidance to address such situations. Likewise, agencies around the world that are responsible for regulating the design, construction and operation of AP1000 R plants are engaged in similar activities. The MDEP AP1000 R Working Group (AP1000 WG) members consist of members from Canada, China, the United Kingdom and the United States. Since the regulatory review of their AP1000 R applications have not been completed by all of these Countries yet, this paper identifies common preliminary approaches to address potential safety improvements for AP1000 R plants as related to lessons learned from the Fukushima Daiichi accident or Fukushima Daiichi-related issues. In seeking common position, regulators will provide input to this paper to reflect their safety conclusions regarding the AP1000 R design and how the design could be enhanced to address Fukushima Daiichi issues. The common preliminary approaches are organized into five sections

Selenium-72 formation via {sup nat}Br(p,x) induced by 100 MeV Protons: Steps towards a novel {sup 72}Se/{sup 72}As generator system

Energy Technology Data Exchange (ETDEWEB)

Ballard, B. [Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Wycoff, D. [Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65211 (United States); Birnbaum, E.R.; John, K.D. [Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Lenz, J.W. [John Lenz and Associates, East Lansing, MI 48823 (United States); Jurisson, S.S. [Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65211 (United States); Cutler, C.S. [Missouri University Research Reactor Center, University of Missouri-Columbia, Columbia, MO 65211 (United States); Nortier, F.M.; Taylor, W.A. [Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Fassbender, M.E., E-mail: mifa@lanl.gov [Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM 87545 (United States)

2012-04-15

Selenium-72 production by the proton bombardment of a natural NaBr target has been successfully demonstrated at the Los Alamos National Laboratory Isotope Production Facility (LANL-IPF). Arsenic-72 (half life 26 h) is a medium-lived positron emitting radionuclide with the major advantage of being formed as the daughter of another 'generator' radioisotope (Se-72, 8.5 d). A {sup 72}Se/{sup 72}As generator would be the preferred mechanism for clinical utilization of {sup 72}As for positron emission tomography (PET). No portable {sup 72}Se/{sup 72}As generator system has been demonstrated for convenient, repeated {sup 72}As elution ('milking'). In this work, we describe {sup 72}Se production and recovery from irradiated NaBr targets using a 100 MeV proton beam. We also introduce an {sup 72}As generator principle based on {sup 72}Se chelation followed by liquid-liquid extraction, which will be transferred to a solid-phase sorption/elution system. - Highlights: Black-Right-Pointing-Pointer A bulk production and processing method for {sup 72}Se using low-toxic NaBr in a high-energy proton beam has been developed. Black-Right-Pointing-Pointer A chelation based principle for a {sup 72}Se/{sup 72}As generator has been demonstrated. Black-Right-Pointing-Pointer Comparison of experimental yields to theoretical predictions resulted in good agreement.

Beta decay of 72Co and excited levels in 72Ni

International Nuclear Information System (INIS)

Grzywacz, R.; Rykaczewski, K.; Sawicka, M.; Pfuetzner, M.; Daugas, J.M.; Belier, G.; Sauvestre, J.E.; Meot, V.; Roig, O.; Giovinazzo, J.; Grawe, H.; Mayet, P.; Matea, I.; Georgiev, G.; Lewitowicz, M.; Olivieira, F. de; Stodel, C.; Saint-Laurent, M. G.; Stanoiu, M.; Verney, D.

2003-01-01

An experiment was performed at GANIL to observe isomeric- and beta-delayed gamma rays from very neutron-rich nuclei around 74Ni. Fragmentation products of the 86Kr beam at 58 AMeV were studied using new devices: the LISE 2000 spectrometer and detectors from the EXOGAM germanium array. The primary aim of the experiment was to find the 8+ microsecond isomer in 76Ni and to perform beta decay spectroscopy of Co nuclei. We have successfully measured the beta delayed gammas from the decay of 72Co to 72Ni. The energies for the lowest excited states in 72Ni are proposed, with the first 2+ state at 1096 keV. These findings suggest a solution of the problem of the disappearance of the 8+ isomer in 72Ni. We also measured beta decay of other neutron-rich Co isotopes including 70Co. First evidence was found for a new short lived isomer, most likely the Iπ=8+ state, in 76Ni

The new German Recycling and Waste management Act (KrWG). Chances and perspectives for the secondary raw materials industry; Das neue Kreislaufwirtschaftsgesetz. Chancen und Perspektiven fuer die Sekundaerrohrstoffwirtschaft

Energy Technology Data Exchange (ETDEWEB)

Landers, Burkhard [Bundesverband Sekundaerrohstoffe und Entsorgung e.V. (BVSE), Bonn (Germany)

2012-11-01

After long discussions concerning wordings, the new German Act on Recycling and Waste Management (KrWG) came into force with the decision of the arbitration panel of 8 February 2012 and the agreement of the German Bundestag and Bundesrat. It took more than two years from the first draft to the new act, and discussions and lawsuits can be expected to continue. The new act still follows the structure of its predecessor, but private industries, especially medium-sized ones, have not been given sufficient scope for action. Politicians were unable to find a fair balance between private and communal interests. Now, with the introduction of a new standard recycling bin, the legislator is held to take account of the interests of the private waste management industry, whose labour and innovative power made a decisive contribution to the success of waste management and recycling in Germany. (orig.) [German] Der letzte Schlusspunkt ist nach zaehem Ringen um einzelne Formulierungen des Kreislaufwirtschaftsgesetzes (KrWG) mit dem Beschluss des Vermittlungsausschusses am 8. Februar 2012 und mit der anschliessenden Zustimmung des Deutschen Bundestages sowie des Bundesrates gesetzt worden. Damit sind seit dem ersten Arbeitsentwurf des Bundesministeriums fuer die Novellierung des Kreislaufwirtschafts- und Abfallrechts mehr als zwei Jahre vergangen, und es bedarf keiner hellseherischen Faehigkeiten um vorherzusagen, dass die Auseinandersetzung ueber einzelne Bestimmungen und nachrangige Verordnungen des Gesetzes vor Gericht und in der Politik noch lange nicht ihren Abschluss gefunden hat. Trotz aller Diskussionen waehrend des Gesetzgebungsverfahrens sind die wesentlichen Grundstrukturen des alten Kreislaufwirtschafts- und Abfallgesetzes auch im neuen KrWG erhalten geblieben. Der Privatwirtschaft, vor allem in der Breite aus vielen mittelstaendischen Unternehmen bestehend, ist jedoch nicht genuegend Handlungsspielraum gewaehrt worden. Der Politik ist es nicht gelungen, einen fairen

Village-scale (Phase III) evaluation of the efficacy and residual activity of SumiShield® 50 WG (Clothianidin 50%, w/w) for indoor spraying for the control of pyrethroid-resistant Anopheles culicifacies Giles in Karnataka state, India.

Science.gov (United States)

Uragayala, S; Kamaraju, R; Tiwari, S N; Sreedharan, S; Ghosh, S K; Valecha, N

2018-03-30

There is an urgent need to test and incorporate new molecules with promising efficacy and novel mode of action to control insecticide-resistant mosquito vectors for disease control. We tested a new compound, clothianidin (SumiShield 50 WG), for its efficacy as an indoor residual spray (IRS) for the control of pyrethroid-resistant Anopheles culicifacies (Diptera: Culicidae) in comparison with pirimiphos methyl (Actellic CS) as a positive control. Ten villages were selected, five each for IRS with clothianidin (300 mg AI/m 2 ) and pirimiphos methyl (1000 mg AI/m 2 ) in Almatti Dam catchment area in Karnataka state, India. Entomological parameters were monitored in these sprayed villages using standard methods. Assessment of quality of spray was performed by analysing the insecticide content in the filter paper samples collected from sprayed houses. Perceptions of spray men and inhabitants were recorded post-spray on safety of these molecules. The mean applied to target ratio of content was 1.7 (n = 29) for clothianidin and 1.8 (n = 50) for pirimiphos methyl on filter paper samples analysed. Residual activity (≥80% mortality in exposed mosquitoes) after 24 h post-exposure of SumiShield WG was 5 months and increased to 6 months when the holding period was extended to 120 h and that of Actellic CS was 3 months at 24-h holding period and extended to 4 months at 120-h extended holding period. The mean densities of An. culicifacies in both arms fell drastically post-spray. In light trap collections, density of mosquitoes collected indoors was lower than outdoors in both arms indicating effectiveness of IRS. SumiShield WG was more efficacious in reducing the per-structure density than Actellic CS. The proportion of nulliparous mosquitoes was higher than that of parous mosquitoes during post-spray collections in both arms. The majority of adverse events reported were transitory and subsided without medication. Indoor residual spraying with SumiShield WG was found effective

MDEP Design-Specific Common Position CP-APR1400WG-01. Common position addressing Fukushima Daiichi nuclear power plant accident

International Nuclear Information System (INIS)

2016-05-01

The MDEP APR1400 Working Group (APR1400WG) members consist of members from Republic of Korea, United Arab Emirates, and the United States. A main objectives of MDEP is to encourage convergence of code, standard and safety goals with exploring the opportunities for harmonization of regulatory practice and cooperation on safety review of APR-1400 specific designs. This common position addressing is aimed at sharing knowledge, information and experience on safety improvement related to lessons learned from the Fukushima Daiichi NPP Accident or Fukushima Daiichi NPP Accident-related issues amongst APR-1400 WG member states to achieve the MEDP goal. Because not all of these Regulators have completed the regulatory review of their APR1400 applications yet, this paper identifies common preliminary approaches to address potential safety improvements for APR1400 plants, as well as common general expectations for new nuclear power plants, as related to lessons learned from the Fukushima Daiichi NPP Accident or Fukushima Daiichi NPP Accident-related issues. While some asymmetry exists among those of three Regulators in terms of design, regulatory practice and licensing milestone sharing information and common understanding on post-Fukushima Daiichi NPP Accident enhancement would be promote resilient design for countering beyond design extreme external event like Fukushima Daiichi NPP nuclear disaster. This common position paper aims at identifying characteristics of post-Fukushima Daiichi NPP Accident enhancements putting in place by each country and setting common position to achieve balanced and harmonized APR-1400 design. After the safety reviews of the APR1400 design applications that are currently in review are completed, the regulators will update this paper to reflect their safety conclusions regarding the APR1400 design and how the design could be enhanced to address Fukushima Daiichi NPP Accident-related issues. The common preliminary approaches are organised into

Electricity and gas distribution networks in competition. At the same time a critical investigation of the legal regulation of the concession right in paragraph 46 EnWG; Strom- und Gasverteilnetze im Wettbewerb. Zugleich eine kritische Untersuchung zur gesetzlichen Regelung des Konzessionsrechts in paragraph 46 EnWG

Energy Technology Data Exchange (ETDEWEB)

Theobald, Christian; Templin, Wolf

2011-07-01

A functioning infrastructure has always been a prerequisite for economic and social development. But the local power supply is in an area of conflict between European law, energy law and antitrust rules. The municipalities engage in a periodic competition in order to guarantee a local network infrastructure. At the same time, an increasing political design intent of the citizens is loomed. Under this aspect, the authors of the contribution under consideration report on a critical, legal and in parts economic investigation of the existing legal framework for the operation of local electricity and gas distribution networks. In particular, the legal regulation of concession right in paragraph 46 EnWG (Energy Economic Law) is investigated.

HERCA WG Medical Applications / WP justification. Survey about the situation in Europe regarding the use of CT on asymptomatic individuals outside screening programs

International Nuclear Information System (INIS)

2013-06-01

In recent years, commercial services offering CT scans to individuals for the detection of lung, cardiac and colorectal disease has been reported in the USA and in some parts of Europe (e.g. Germany and the UK). Some of these private services are associated with aggressive advertisement and are in conflict with the general principle of justification. Faced with this situation, in July 2012, HERCA WG Medical Applications launched a survey about the situation in Europe regarding the use of CT on asymptomatic individuals outside screening programs for group 2.c. This document presents the results of the survey

9 CFR 354.72 - Packaging.

Science.gov (United States)

2010-01-01

... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Packaging. 354.72 Section 354.72... CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Supervision of Marking and Packaging § 354.72 Packaging. No container which bears or may bear any official identification or any abbreviation...

28 CFR 72.2 - Definitions.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Definitions. 72.2 Section 72.2 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) SEX OFFENDER REGISTRATION AND NOTIFICATION § 72.2 Definitions. All terms used in this part that are defined in section 111 of the Sex Offender Registration and...

29 CFR 570.72 - Exemptions.

Science.gov (United States)

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Exemptions. 570.72 Section 570.72 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS CHILD LABOR... the Employment of Children Below the Age of 16 § 570.72 Exemptions. (a) Student-learners. The findings...

10 CFR 72.2 - Scope.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Scope. 72.2 Section 72.2 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General Provisions § 72.2 Scope. (a) Except...

6 CFR 7.2 - Scope.

Science.gov (United States)

2010-01-01

..., National Industrial Security Program, and its implementing directives. (c) This part is independent of and... 6 Domestic Security 1 2010-01-01 2010-01-01 false Scope. 7.2 Section 7.2 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION § 7.2 Scope...

Compliance of blood sampling procedures with the CLSI H3-A6 guidelines: An observational study by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) working group for the preanalytical phase (WG-PRE)

NARCIS (Netherlands)

Simundic, Ana-Maria; Church, Stephen; Cornes, Michael P.; Grankvist, Kjell; Lippi, Giuseppe; Nybo, Mads; Nikolac, Nora; van Dongen-Lases, Edmee; Eker, Pinar; Kovalevskaya, Svjetlana; Kristensen, Gunn B. B.; Sprongl, Ludek; Sumarac, Zorica

2015-01-01

Abstract Background: An observational study was conducted in 12 European countries by the European Federation of Clinical Chemistry and Laboratory Medicine Working Group for the Preanalytical Phase (EFLM WG-PRE) to assess the level of compliance with the CLSI H3-A6 guidelines. Methods: A structured

Job Grading Standard for Materials Expediter WG-6705.

Science.gov (United States)

Civil Service Commission, Washington, DC. Bureau of Policies and Standards.

The standard is used to grade nonsupervisory jobs involved in routing and expediting the movement of parts, end items, supplies, and materials within production and repair facilities to meet priority needs. The work requires knowledge of material characteristics, uses, condition, industrial production shop procedures, shop layout, and internal…

75 FR 66423 - Seventh Meeting: RTCA Special Committee 223: Airport Surface Wireless Communications

Science.gov (United States)

2010-10-28

..., Administrative Remarks by Special Committee Leadership Designated Federal Official (DFO): Mr. Brent Phillips Co... Session User Services and Applications Definition Wednesday Afternoon--Reconvene Plenary Profiles WG...

Network or non-network? The status of customer installations in the German Energy Economy Law; Netz oder nicht-Netz? Die Stellung von Kundenanlagen im EnWG

Energy Technology Data Exchange (ETDEWEB)

Helmes, Sebastian [Sozietaet SCHOLTKA und PARTNER Rechtsanwaelte, Berlin (Germany)

2013-01-15

It is widespread practice for final consumers to procure their energy supply through the ''private'' installations of third parties, that is, outside the public supply grids. This applies to many industrial sites with their own, historically evolved supply structures but also to airports, office buildings, camping sites and hotels. The regulatory treatment of this category of energy distribution plant is anything but trivial. Until the enactment of the 2011 amendment to the Energy Economy Law (EnWG) these installations were often regarded as object-related networks not amenable to regulation, a position which the European Court of Justice saw as violating European law in some cases. In view of the fact that the successor regulation concerning ''stand-alone distribution networks'' in paragraph 110 EnWG provides little scope for privileges, many today consider the concept of ''customer installation'', which only came under explicit regulation through the 2011 amendment, to be the ideal way to keep these installations clear of regulation. Customer installations do not count as energy distribution plants. One question that yet remains to be defined by law is at what point the regulated grid ends and the customer installation begins. This delimitation is fraught with problems because it touches on many legal concepts requiring interpretation. Another question quite aside from this is whether the legislature might have yet again violated European law through these provisions.

Summary records of meetings of INFCE WG3. First to seventh series of meetings

International Nuclear Information System (INIS)

The topics discussed in this working group refer to very specific problems of the fuel cycle: Uranium supply, uranium enrichment, the heavy-water reactor, the back end of the fuel cycle, non-proliferation aspects, and the special needs of developing countries. The key problems put up for discussion are presented

78 FR 68853 - International Medical Device Regulators Forum; Medical Device Single Audit Program International...

Science.gov (United States)

2013-11-15

... its inaugural meeting in Singapore in 2012, identified a Work Group (WG) to develop specific documents... Assessment Method for the Recognition and Monitoring of Medical Device Auditing Organizations;'' and IMDRF...

75 FR 14483 - Third Meeting: RTCA Special Committee 223: Airport Surface Wireless Communications

Science.gov (United States)

2010-03-25

.../SC223-005) Special Committee Leadership Designated Federal Official (DFO): Mr. Brent Phillips Co-Chair... Continue AeroMACS Profile definition Wednesday Afternoon--Reconvene Plenary Profiles WG Status Report and...

7 CFR 1780.72 - Procurement methods.

Science.gov (United States)

2010-01-01

... 7 Agriculture 12 2010-01-01 2010-01-01 false Procurement methods. 1780.72 Section 1780.72..., Constructing and Inspections § 1780.72 Procurement methods. Procurement shall be made by one of the following methods: Small purchase procedures; competitive sealed bids (formal advertising); competitive negotiation...

42 CFR 460.72 - Physical environment.

Science.gov (United States)

2010-10-01

... 42 Public Health 4 2010-10-01 2010-10-01 false Physical environment. 460.72 Section 460.72 Public...) PACE Administrative Requirements § 460.72 Physical environment. (a) Space and equipment—(1) Safe design..., sanitary, functional, accessible, and comfortable environment for the delivery of services that protects...

26 CFR 1.72-1 - Introduction.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Introduction. 1.72-1 Section 1.72-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Items Specifically Included in Gross Income § 1.72-1 Introduction. (a) General...

10 CFR 1040.72 - Existing facilities.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Existing facilities. 1040.72 Section 1040.72 Energy... § 1040.72 Existing facilities. (a) Accessibility. A recipient shall operate any program or activity to... facilities or every part of a facility accessible to and useable by handicapped persons. (b) Methods. A...

30 CFR 7.72 - New technology.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false New technology. 7.72 Section 7.72 Mineral... MINING PRODUCTS TESTING BY APPLICANT OR THIRD PARTY Multiple-Shot Blasting Units § 7.72 New technology. MSHA may approve a blasting unit that incorporates technology for which the requirements of this...

9 CFR 72.25 - Dipping methods.

Science.gov (United States)

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Dipping methods. 72.25 Section 72.25 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... CATTLE § 72.25 Dipping methods. Dipping is accomplished by thoroughly wetting the entire skin by either...

46 CFR 72.20-15 - Construction.

Science.gov (United States)

2010-10-01

... 46 Shipping 3 2010-10-01 2010-10-01 false Construction. 72.20-15 Section 72.20-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS CONSTRUCTION AND ARRANGEMENT Accommodations for Officers and Crew § 72.20-15 Construction. All crew spaces are to be constructed and arranged...

40 CFR 73.72 - Direct sales.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Direct sales. 73.72 Section 73.72... ALLOWANCE SYSTEM Auctions, Direct Sales, and Independent Power Producers Written Guarantee § 73.72 Direct sales. Allowances that were formerly part of the direct sale program, which has been terminated under...

46 CFR 72.10-10 - Location.

Science.gov (United States)

2010-10-01

... 46 Shipping 3 2010-10-01 2010-10-01 false Location. 72.10-10 Section 72.10-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS CONSTRUCTION AND ARRANGEMENT Means of Escape § 72.10-10 Location. (a) The two means of escape shall be as remote as practicable so as to minimize...

21 CFR 211.72 - Filters.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Filters. 211.72 Section 211.72 Food and Drugs FOOD... shall not release fibers into such products. Fiber-releasing filters may be used when it is not possible to manufacture such products without the use of these filters. If use of a fiber-releasing filter is...

19 CFR 210.72 - Confidentiality of information.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Confidentiality of information. 210.72 Section 210.72 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Enforcement Procedures and Advisory Opinions § 210.72...

41 CFR 105-72.307 - Allowable costs.

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Allowable costs. 105-72.307 Section 105-72.307 Public Contracts and Property Management Federal Property Management... Administration 72-UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER...

Law for Accelerated Network Expansion (NABEG) / Law on the Expansion of Energy Supply Lines (EnLAG) / Energy Economy Law (EnWG). Commentary on laws concerning the construction of energy supply lines.; NABEG/EnLAG/EnWG. Kommentar zum Recht des Energieleitungsbaus

Energy Technology Data Exchange (ETDEWEB)

Steinbach, Armin (ed.) [Bundeswirtschaftsministerium, Berlin (Germany)

2013-09-01

The legislative package which launched the energy turnaround in 2011 has brought with it a fundamental reform of licensing regulations for energy supply lines. The new legal framework brought about by the Law for Accelerated Network Expansion (NABEG) and the amendment to the Energy Economy Law (EnWG) impact on the entire planning and licensing process, starting from demand planning for new supply lines and ending with planning approval for specific supply line projects. The instrument of special federal planning has taken the place of regional impact assessments. Moreover a number of procedural innovations have been introduced, notably in the area of public participation. Beside being charged with regulatory tasks the Federal Network Agency will in future also be the authority responsible for the planning and licensing of the electricity motorways. In short: With this reform the legislature has ventured on untrodden ground both in institutional terms and with respect to substantive law. The new regulations confront all involved - network operators, public authorities, legal consultants and others - with the challenge of applying them in practice. The present book is intended to provide practical orientation in interpreting and applying this new body of regulations.

48 CFR 836.606-72 - Contract price.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract price. 836.606-72 Section 836.606-72 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SPECIAL...-72 Contract price. (a) Where negotiations with the top-rated firm are unsuccessful, the contracting...

48 CFR 1815.203-72 - Risk management.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Risk management. 1815.203-72 Section 1815.203-72 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... Proposals and Information 1815.203-72 Risk management. In all RFPs and RFOs for supplies or services for...

46 CFR 72.01-20 - Special consideration.

Science.gov (United States)

2010-10-01

... 46 Shipping 3 2010-10-01 2010-10-01 false Special consideration. 72.01-20 Section 72.01-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS CONSTRUCTION AND ARRANGEMENT Hull Structure § 72.01-20 Special consideration. (a) Special consideration will be given to the...

10 CFR 72.184 - Safeguards contingency plan.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Safeguards contingency plan. 72.184 Section 72.184 Energy... Protection § 72.184 Safeguards contingency plan. (a) The requirements of the licensee's safeguards contingency plan for responding to threats and radiological sabotage must be as defined in appendix C to part...

30 CFR 72.520 - Diesel equipment inventory.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Diesel equipment inventory. 72.520 Section 72... Mines § 72.520 Diesel equipment inventory. (a) The operator of each mine that utilizes diesel equipment underground, shall prepare and submit in writing to the District Manager, an inventory of diesel equipment...

Obligations to transmission grid enlargement and cooperation of operators of transmission grids after the enactment of EnLAG and the Third regulation of single market for electricity 2009/72 EG from 13th July, 2009; Netzausbau- und Kooperationsverpflichtungen der Uebertragungsnetzbetreiber nach Inkrafttreten des EnLAG und der Dritten StromRL 2009/72 EG vom 13.7.2009

Energy Technology Data Exchange (ETDEWEB)

Saecker, Franz Juergen [Hogan und Hartson Raue LLP/LBD Beratungsgesellschaft mbH, Berlin (Germany)

2009-10-15

paragraph 11 EnWG (Energy Economy Law) in the version of the Electricity Grid Expansion Act (EnLAG) obliges the operators of transmission grids to an optimization of transmission grids. The obligation for optimization refers to the development of the existing grids and to an extended co-operation of the operators of transmission grids for the improvement of the transmission of the electricity. Under this aspect, the author of the contribution under consideration reports on: (a) Contents of the obligation for the optimization of transmission grids and the development of transmission grids; (b) Fulfilment of the obligation for co-operation in accordance with paragraph 12 sect. 1 and paragraph 22 sect. 2 sentence 4 EnWG by forming a virtual grid company for the transmission of electricity; (c) Model of a cooperation contract; (d) Formation of a 'Deutsches Netz AG' as an alternative concept.

11 CFR 100.72 - Testing the waters.

Science.gov (United States)

2010-01-01

... 11 Federal Elections 1 2010-01-01 2010-01-01 false Testing the waters. 100.72 Section 100.72 Federal Elections FEDERAL ELECTION COMMISSION GENERAL SCOPE AND DEFINITIONS (2 U.S.C. 431) Exceptions to Contributions § 100.72 Testing the waters. (a) General exemption. Funds received solely for the purpose of...

22 CFR 72.4 - Notifications of death.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Notifications of death. 72.4 Section 72.4... DEATHS AND ESTATES Reporting Deaths of United States Nationals § 72.4 Notifications of death. The... legal representative (if any, and if different from the next of kin), of the death of a United States...

33 CFR 72.05-5 - Sales agencies.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Sales agencies. 72.05-5 Section 72.05-5 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION MARINE INFORMATION Light Lists § 72.05-5 Sales agencies. Each volume of the Light List is for sale...

46 CFR 72.10-35 - Public spaces.

Science.gov (United States)

2010-10-01

... 46 Shipping 3 2010-10-01 2010-10-01 false Public spaces. 72.10-35 Section 72.10-35 Shipping COAST... of Escape § 72.10-35 Public spaces. (a) In all cases, public spaces having a deck area of over 300... corridors, rooms, or spaces to minimize the possibility of one incident blocking both exits. (b) [Reserved] ...

46 CFR 72.20-35 - Hospital space.

Science.gov (United States)

2010-10-01

... 46 Shipping 3 2010-10-01 2010-10-01 false Hospital space. 72.20-35 Section 72.20-35 Shipping COAST... Accommodations for Officers and Crew § 72.20-35 Hospital space. (a) Each vessel which in the ordinary course of... more, must be provided with a hospital space. This space must be situated with due regard to the...

46 CFR 72.40-10 - Storm rails.

Science.gov (United States)

2010-10-01

... 46 Shipping 3 2010-10-01 2010-10-01 false Storm rails. 72.40-10 Section 72.40-10 Shipping COAST... and Guards § 72.40-10 Storm rails. (a) Suitable storm rails shall be installed in all passageways and at the deckhouse sides where passengers or crew might have normal access. Storm rails shall be...

7 CFR 1212.72 - Confidential treatment.

Science.gov (United States)

2010-01-01

... statements based upon the reports of the number of persons subject to this subpart or statistical data... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidential treatment. 1212.72 Section 1212.72 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING...

10 CFR 72.10 - Employee protection.

Science.gov (United States)

2010-01-01

... adverse action occurs because the employee has engaged in protected activities. An employee's engagement... 10 Energy 2 2010-01-01 2010-01-01 false Employee protection. 72.10 Section 72.10 Energy NUCLEAR... Employee protection. (a) Discrimination by a Commission licensee, certificate holder, an applicant for a...

7 CFR 996.72 - Confidential information.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Confidential information. 996.72 Section 996.72 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... condition, or business operations of the particular handlers or their customers shall be received by, and at...

27 CFR 71.72 - Before citation.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Before citation. 71.72... Procedure Surrender of Permit § 71.72 Before citation. If a respondent surrenders the permit before citation... appropriate TTB officer, warrants citation for suspension, revocation or annulment, the surrender shall be...

10 CFR 72.162 - Test control.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Test control. 72.162 Section 72.162 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL... Test control. The licensee, applicant for a license, certificate holder, and applicant for a CoC shall...

48 CFR 552.236-72 - Specialist.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Specialist. 552.236-72... FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 552.236-72 Specialist. As prescribed in 536.570-3, insert the following clause: Specialist (APR 1984) The term “Specialist...

36 CFR 72.13 - Action plan.

Science.gov (United States)

2010-07-01

... objectives, priorities and implementation strategies in relation to the intent of the Urban Park and... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Action plan. 72.13 Section 72.13 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK...

10 CFR 72.152 - Document control.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Document control. 72.152 Section 72.152 Energy NUCLEAR... Document control. The licensee, applicant for a license, certificate holder, and applicant for a CoC shall establish measures to control the issuance of documents such as instructions, procedures, and drawings...

10 CFR 72.146 - Design control.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Design control. 72.146 Section 72.146 Energy NUCLEAR... Design control. (a) The licensee, applicant for a license, certificate holder, and applicant for a CoC... shall establish measures for the identification and control of design interfaces and for coordination...

48 CFR 1252.217-72 - Performance.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Performance. 1252.217-72... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 1252.217-72 Performance. As prescribed at (TAR) 48 CFR 1217.7001(b) and (c), insert the following clause: Performance (OCT 1994) (a) Upon...

A Preliminary Study of Staff Meetings as Viewed by Dental Hygienists

Directory of Open Access Journals (Sweden)

Patrick Anderson

2011-12-01

Full Text Available Staff meetings in general dental practices represent what is be-lieved to be a key management strategy to build teams and to enhance efficiency and effec-tiveness. However, very little research has been done regarding staff meetings in dental offices. This study examined staff meetings from the viewpoint of dental hygienists who grow in unique careers in that they work largely independently of the dentist and yet typically within a dental practice while providing patient care and education. One-hundred-six dental hygienists completed a survey about staff meetings in dental offices. Key findings include: only approximately 43% of dental offices conduct morning huddles to get the day off to a smooth and organized start, 72% of dental practices conduct longer staff meetings with largely positive outcomes, including increasing practice efficiency and productivity, few practices (12% hold specific meetings only for the hygiene-department (and probably thereby miss some opportunities for practice im-provement, the most important variable by far to hygienists' job satisfaction is respect from the owner-dentist, and there exists an important and synergistic relationship among job sa-tisfaction, relationships with other staff and relationship with the owner-dentist.

27 CFR 19.72 - Other businesses.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Other businesses. 19.72... Activities Not Subject to This Part § 19.72 Other businesses. Application to conduct at a distilled spirits plant a type of business other than that of a distiller, warehouseman, or processor may be approved by...

48 CFR 852.246-72 - Frozen processed foods.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Frozen processed foods. 852.246-72 Section 852.246-72 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... Frozen processed foods. As prescribed in 846.302-72, insert the following clause: Frozen Processed Foods...

34 CFR 668.72 - Nature of educational program.

Science.gov (United States)

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false Nature of educational program. 668.72 Section 668.72... EDUCATION, DEPARTMENT OF EDUCATION STUDENT ASSISTANCE GENERAL PROVISIONS Misrepresentation § 668.72 Nature of educational program. Misrepresentation by an institution of the nature of its educational program...

10 CFR 72.150 - Instructions, procedures, and drawings.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Instructions, procedures, and drawings. 72.150 Section 72... WASTE Quality Assurance § 72.150 Instructions, procedures, and drawings. The licensee, applicant for a... documented instructions, procedures, or drawings of a type appropriate to the circumstances and shall require...

40 CFR 60.72 - Standard for nitrogen oxides.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Standard for nitrogen oxides. 60.72 Section 60.72 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Plants § 60.72 Standard for nitrogen oxides. (a) On and after the date on which the performance test...

O despontar da educação especial na ANPED Surfacing of special education in ANPED

Directory of Open Access Journals (Sweden)

Elcie F. Salzano Masini

2011-08-01

and researchers in Special Education from different Brazilian universities that discussed the importance of forming a WG of Special Education in ANPEd. A calendar of meetings that aimed the discussion of Special Education research and legislation was agreed, and an official letter requesting a special appointment for Special Education during ANPEd meetings was sent to their directors. The letter justified this request highlighting that the inclusion of the subject Special Education in the university curriculum, especially in undergraduate teaching courses, arose the need for developing research bound to Special Education graduate courses. As a result to that request, the Study Group (SG was created in ANPEd in 1989. This article describes the functioning of the SG, the program, the participants and the cooperative research involving six Brazilian States, which moved the GS forward the WG. Special Education was included as a WG in the XV Annual Meeting of ANPEd in 1992. In that year the WG participants decided about the objectives and functioning of the WG. Upon the closing of the XV ANPEd Meeting, the first coordinator of the Special Education WG, a professor from the School of Education at the University of São Paulo, who coordinated the WG from 1989 until 1992, passed the coordination to a professor from the School of Education at Rio de Janeiro State University.

10 CFR 72.158 - Control of special processes.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Control of special processes. 72.158 Section 72.158 Energy... NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE Quality Assurance § 72.158 Control of special processes. The licensee, applicant for a license, certificate holder...

Achados oculares em pacientes com mielomeningocele: 72 casos Ocular findings in 72 patients with meningomyelocele

Directory of Open Access Journals (Sweden)

Mônica Fialho Cronemberger

2000-10-01

Full Text Available Objetivo: Estudar as alterações oculares em pacientes com mielomeningocele. Material e Método: Realizado estudo retrospectivo em 72 pacientes com mielomeningocele, descrevendo as alterações oculares presentes nessa população, além de correlacionar com a presença ou não de hidrocefalia. Resultados: Dos 72 pacientes com mielomeningocele, com idade variando de 5 meses a 18 anos, 64 (88,9% pacientes tinham hidrocefalia. Destes 64 pacientes, 36 (56,3% tinham estrabismo, sendo que 21 (58,3% eram endotrópicos, 13 (36,1% exotrópicos, 1 (2,8% exofórico e 1 (2,8% com estrabismo discinético. Do total dos 72 pacientes estudados 38 (52,8% eram estrábicos. A anisotropia foi encontrada em 16 (22,2% pacientes, sendo que em 14 (87,5% em A e em 2 (12,5% em V. Todos os 16 pacientes com anisotropia apresentavam hidrocefalia. O erro refrativo mais freqüente foi a hipermetropia encontrada em 64 (44,4% olhos. Atrofia óptica foi encontrada em 9 (12,5% pacientes. Conclusão: A mielomeningocele, associada a hidrocefalia, apresenta uma porcentagem de estrabismo maior do que o encontrado na população normal.Purpose: To study ocular findings in patients with meningomyelocele. Methods: A retrospective study of 72 patients with myelomeningocele was performed to evaluate ocular motility disorders, refractive errors and indirect ophthalmoscopy findings. Results: In a group of 72 patients with myelomeningocele, aged 5 month -- 18 years, 64 (88.9% had hydrocephalus. Of this group of 64 patients, 36 (56.3% had strabismus, 21 (58.3% of whom were esotropic, and 13 (36.1% exotropic, 1 (2.8% exophoric and 1 (2.8% presented sometimes esotropia and sometimes exotropia. Of the total of 72 studied patients, 38 (52.8% had strabismus. Anisotropia was found in 16 (22.2% patients, 14 (87.5% with an A pattern and 2 (12.5% with a V pattern. The most frequent refractive error was hyperopia, found in 64 (44.4% eyes. All the 16 patients with anisotropia had hydrocephalus

22 CFR 72.6 - Report of presumptive death.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Report of presumptive death. 72.6 Section 72.6... DEATHS AND ESTATES Reporting Deaths of United States Nationals § 72.6 Report of presumptive death. (a) Local finding. When there is a local finding of presumptive death by a competent local authority, a...

27 CFR 4.72 - Metric standards of fill.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Metric standards of fill. 4.72 Section 4.72 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF WINE Standards of Fill for Wine § 4.72 Metric...

46 CFR 72.05-30 - Windows and airports.

Science.gov (United States)

2010-10-01

... 46 Shipping 3 2010-10-01 2010-10-01 false Windows and airports. 72.05-30 Section 72.05-30 Shipping... Structural Fire Protection § 72.05-30 Windows and airports. (a) For the purpose of this subpart, all glass in windows or airports shall be at least 1/4 inch thick. However, greater thickness may be required for...

46 CFR 72.20-50 - Heating and cooling.

Science.gov (United States)

2010-10-01

... 46 Shipping 3 2010-10-01 2010-10-01 false Heating and cooling. 72.20-50 Section 72.20-50 Shipping... Accommodations for Officers and Crew § 72.20-50 Heating and cooling. (a) All manned spaces must be adequately heated and cooled in a manner suitable to the purpose of the space. (b) The heating and cooling system...

22 CFR 72.5 - Final report of death.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Final report of death. 72.5 Section 72.5... DEATHS AND ESTATES Reporting Deaths of United States Nationals § 72.5 Final report of death. (a) Preparation. Except in the case of the death of an active duty member of the United States Armed Forces, when...

Impact of the lung oncology multidisciplinary team meetings on the management of patients with cancer.

Science.gov (United States)

Ung, Kim Ann; Campbell, Belinda A; Duplan, Danny; Ball, David; David, Steven

2016-06-01

Multidisciplinary team (MDT) meetings are increasingly regarded as a component of multidisciplinary cancer care. We aimed to prospectively measure the impact of MDT meetings on clinicians' management plans for lung oncology patients, and the implementation rate of the meeting recommendations. Consecutive patient cases presented at the weekly lung oncology MDT meetings were prospectively enrolled. Investigators compared the clinicians' management plans pre-meeting with the consensus plans post-meeting. The meeting was considered to have an impact on management plans if ≥1 of the following changes were detected: tumor stage, histology, treatment intent or treatment modality, or if additional investigations were recommended. Investigators reviewed hospital patient records at 4 months to determine if the meeting recommendations were implemented. Reasons for non-implementation were also recorded. Of the 55 eligible cases, the MDT meeting changed management plans in 58% (CI 45-71%; P management plans for lung oncology patients. The majority of MDT recommendations (72%) were implemented into patient care. These findings provide further evidence to support the role of MDT meetings as an essential part of the decision-making process for the optimal multidisciplinary management of patients with cancer. © 2014 Wiley Publishing Asia Pty Ltd.

INMM/ESARDA meeting. Report of the WG2 on Advanced Sensor Technology

International Nuclear Information System (INIS)

Harry, J.; Sanders, K.

1999-01-01

In this report the subjects are first presented by a summary of the five questions that were used as guidance for the discussions, followed by a narrative summary of the discussion and the presentation. The two papers on respectively source triggered multiplicity measurements and high order correlation studies were summarized in one combined narrative report. Throughout this report the five questions will be indicated by their keywords that represent the following questions: (1) What is the problem or issue being addressed?; (2) What new or unique information, insight, approach, or technology is being presented to address the problem or issue?; (3) What is the status of the issue, technology, or approach (i.e., is it theoretical, speculative, under development, already applied to non-safeguards areas?); (4) What benefits or improvements have been or might be achieved from the practical incorporation or application of the technology or approach?; and (5) Is the technology, approach, or insight applicable to safeguards or to other non-proliferation areas? If so, to what problems or areas could it apply?

75 FR 20423 - Tenth Meeting: RTCA Special Committee 214: Working Group 78: Standards for Air Traffic Data...

Science.gov (United States)

2010-04-19

... so far SPR & INT documents version H SC-214/WG-78 TORs and Work Plan Review of Position Papers.... Francisco Estrada C., RTCA Advisory Committee. [FR Doc. 2010-8849 Filed 4-16-10; 8:45 am] BILLING CODE 4910...

Update in cardiomyopathies and congestive heart failure

Directory of Open Access Journals (Sweden)

The Heart Hospital, London, UK and Monaldi Hospital, Naples, Italy

2012-05-01

Full Text Available This abstract book contains four reports and all abstracts presented to the Joint Meeting: Update in cardiomyopathies and congestive heart failure, 22-23 September 2011 - Naples, Italy, endorsed by the Working Group on Myocardial and Pericardial Diseases (WG 21 of the European Society of Cardiology (ESC.

48 CFR 828.106-72 - Contract provision.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract provision. 828... GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds and Other Financial Protections 828.106-72 Contract provision. Insert 852.228-72, Assisting Service-Disabled Veteran-Owned and Veteran-Owned Small...

14 CFR 33.72 - Hydraulic actuating systems.

Science.gov (United States)

2010-01-01

... AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Design and Construction; Turbine Aircraft Engines § 33.72 Hydraulic actuating systems. Each hydraulic actuating system must function properly under all conditions in which the... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Hydraulic actuating systems. 33.72 Section...

41 CFR 105-72.504 - Procurement procedures.

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Procurement procedures. 105-72.504 Section 105-72.504 Public Contracts and Property Management Federal Property Management... acceptable characteristics or minimum acceptable standards. (iv) The specific features of “brand name or...

75 FR 61818 - Eighty-Third Meeting: RTCA Special Committee 159: Global Positioning System (GPS).

Science.gov (United States)

2010-10-06

..., Working Group 2C, GPS/Inertial, MacIntosh-NBAA Room and Hilton-ATA Room. Tuesday, October 26 All Day... and Hilton-ATA Room. Thursday, October 28 (Proposed) 9--Noon, Joint Working Groups 2 & 4, Discussion--Nav and ADS-B Out Equipment Requirements, MacIntosh-NBAA Room and Hilton-ATA Room. (Otherwise WG-4...

Investigation of G72 (DAOA expression in the human brain

Directory of Open Access Journals (Sweden)

Hirsch Steven

2008-12-01

Full Text Available Abstract Background Polymorphisms at the G72/G30 locus on chromosome 13q have been associated with schizophrenia or bipolar disorder in more than ten independent studies. Even though the genetic findings are very robust, the physiological role of the predicted G72 protein has thus far not been resolved. Initial reports suggested G72 as an activator of D-amino acid oxidase (DAO, supporting the glutamate dysfunction hypothesis of schizophrenia. However, these findings have subsequently not been reproduced and reports of endogenous human G72 mRNA and protein expression are extremely limited. In order to better understand the function of this putative schizophrenia susceptibility gene, we attempted to demonstrate G72 mRNA and protein expression in relevant human brain regions. Methods The expression of G72 mRNA was studied by northern blotting and semi-quantitative SYBR-Green and Taqman RT-PCR. Protein expression in human tissue lysates was investigated by western blotting using two custom-made specific anti-G72 peptide antibodies. An in-depth in silico analysis of the G72/G30 locus was performed in order to try and identify motifs or regulatory elements that provide insight to G72 mRNA expression and transcript stability. Results Despite using highly sensitive techniques, we failed to identify significant levels of G72 mRNA in a variety of human tissues (e.g. adult brain, amygdala, caudate nucleus, fetal brain, spinal cord and testis human cell lines or schizophrenia/control post mortem BA10 samples. Furthermore, using western blotting in combination with sensitive detection methods, we were also unable to detect G72 protein in a number of human brain regions (including cerebellum and amygdala, spinal cord or testis. A detailed in silico analysis provides several lines of evidence that support the apparent low or absent expression of G72. Conclusion Our results suggest that native G72 protein is not normally present in the tissues that we analysed

36 CFR 72.50 - Grant selection criteria.

Science.gov (United States)

2010-07-01

... effective means of delivering a recreation service that can serve as a model for other communities. (2....50 Section 72.50 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Grant Selection, Approval and Administration § 72...

36 CFR 72.46 - Citizen participation requirements.

Science.gov (United States)

2010-07-01

... B), but is not required in the process of preparing a local Recovery Action Program grant... requirements. 72.46 Section 72.46 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Grants for Recovery Action Program Development...

48 CFR 2901.603-72 - Administrative procurement management reviews.

Science.gov (United States)

2010-10-01

... Authority, and Responsibilities 2901.603-72 Administrative procurement management reviews. (a) The Senior... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Administrative procurement management reviews. 2901.603-72 Section 2901.603-72 Federal Acquisition Regulations System DEPARTMENT OF...

10 CFR 72.144 - Quality assurance program.

Science.gov (United States)

2010-01-01

... quality history and degree of standardization of the item. (d) The licensee, applicant for a license... 10 Energy 2 2010-01-01 2010-01-01 false Quality assurance program. 72.144 Section 72.144 Energy... NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE Quality...

41 CFR 105-72.304 - Program income.

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Program income. 105-72... Management § 105-72.304 Program income. (a) Federal awarding agencies shall apply the standards set forth in this section in requiring recipient organizations to account for program income related to projects...

27 CFR 72.24 - Corporate surety bonds.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Corporate surety bonds. 72... Seizures and Forfeitures § 72.24 Corporate surety bonds. (a) Corporate surety bonds may be given only with... obtained from the Audit Staff, Bureau of Government Financial Operations, Department of the Treasury...

27 CFR 72.25 - Deposit of collateral.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Deposit of collateral. 72... Seizures and Forfeitures § 72.25 Deposit of collateral. (a) Bonds or notes of the United States, or other... be pledged and deposited by claimants as collateral security in lieu of corporate sureties in...

International VLBI Service for Geodesy and Astrometry: General Meeting Proceedings

Science.gov (United States)

Vandenberg, Nancy R. (Editor); Baver, Karen D. (Editor)

2002-01-01

This volume contains the proceedings of the second General Meeting of the International VLBI Service for Geodesy and Astrometry (IVS), held in Tsukuba, Japan, February 4-7, 2002. The contents of this volume also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/gm2002. The key-note of the second GM was prospectives for the future, in keeping with the re-organization of the IAG around the motivation of geodesy as 'an old science with a dynamic future' and noting that providing reference frames for Earth system science that are consistent over decades on the highest accuracy level will provide a challenging role for IVS. The goal of the meeting was to provide an interesting and informative program for a wide cross section of IVS members, including station operators, program managers, and analysts. This volume contains 72 papers and five abstracts of papers presented at the GM. The volume also includes reports about three splinter meetings held in conjunction with the GM: a mini-TOW (Technical Operations Workshop), the third IVS Analysis Workshop and a meeting of the analysis working group on geophysical modeling.

48 CFR 1852.209-72 - Composition of the contractor.

Science.gov (United States)

2010-10-01

... contractor. 1852.209-72 Section 1852.209-72 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND... and Clauses 1852.209-72 Composition of the contractor. As prescribed in 1809.670, insert the following clause: Composition of the Contractor (DEC 1988) If the Contractor is comprised of more than one legal...

Quercetin suppresses heat shock-induced nuclear translocation of Hsp72

Directory of Open Access Journals (Sweden)

Antoni Gawron

2011-08-01

Full Text Available The effect of quercetin and heat shock on the Hsp72 level and distribution in HeLa cells was studied by Western blotting, indirect immunofluorescence and immunogold electron microscopy. In control cells and after quercetin treatment, Hsp72 was located both in the cytoplasm and in the nucleus in comparable amounts. After hyperthermia, the level of nuclear Hsp72 raised dramatically. Expression of Hsp72 in cytoplasm was also higher but not to such extent as that observed in the nucleus. Preincubation of heated cells with quercetin inhibited strong Hsp72 expression observed after hyperthermia and changed the intracellular Hsp72 distribution. The cytoplasmic level of protein exceeded the nuclear one, especially around the nucleus, where the coat of Hsp72 was noticed. Observations indicating that quercetin was present around and in the nuclear envelope suggested an involvement of this drug in the inhibition of nuclear translocation. Our results indicate that pro-apoptotic activity of quercetin may be correlated not only with the inhibition of Hsp72 expression but also with suppression of its migration to the nucleus.

27 CFR 9.72 - Southeastern New England.

Science.gov (United States)

2010-04-01

.... 9.72 Section 9.72 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... viticultural area is located in the counties of New Haven, New London, and Middlesex in Connecticut; in the... on the “Hartford” U.S.G.S. map in New Haven Harbor; (1) Then north following the Quinnipiac River to...

10 CFR 72.212 - Conditions of general license issued under § 72.210.

Science.gov (United States)

2010-01-01

..., considering potential amplification of earthquakes through soil-structure interaction, and soil liquefaction potential or other soil instability due to vibratory ground motion; and (C) the requirements of § 72.104... the Safety Analysis Report (SAR) referenced in the Certificate of Compliance and the related NRC...

46 CFR 72.05-20 - Stairways, ladders, and elevators.

Science.gov (United States)

2010-10-01

... 46 Shipping 3 2010-10-01 2010-10-01 false Stairways, ladders, and elevators. 72.05-20 Section 72.05-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS CONSTRUCTION AND ARRANGEMENT Structural Fire Protection § 72.05-20 Stairways, ladders, and elevators. (a)(1) Except as further noted the provisions of this...

72th Annual Meeting | Annual Meetings | Events | Indian Academy of ...

Indian Academy of Sciences (India)

Convener: R Gadagkar) ... of decline? Social sciences-humanities education in India ... MGK Menon, President, Indian Statistical Institute, New Delhi The changing ... of Delhi, Delhi Breeding of mustard through conventional and molecular methods.

26 CFR 1.72-6 - Investment in the contract.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Investment in the contract. 1.72-6 Section 1.72... (CONTINUED) INCOME TAXES (CONTINUED) Items Specifically Included in Gross Income § 1.72-6 Investment in the contract. (a) General rule. (1) For the purpose of computing the “investment in the contract”, it is first...

GPR surveying of transport infrastructures and buildings; underground utility and void sensing - ongoing activities in Working Group 2 of COST Action TU1208

Science.gov (United States)

Pajewski, Lara; Plati, Christina; Derobert, Xavier

2015-04-01

areas.' Project 2.4 focuses on the development of 'Innovative procedures for effective GPR inspection of construction materials and structures.' The WG2 also includes Project 2.5 on the 'Determination, by using GPR, of the volumetric water content in structures, sub-structures, foundations and soil,' this is a topic of great interest in civil engineering, as water infiltration is often a relevant cause of degradation of structures, such as roads of bridges, and of rebar corrosion. During the first year of the Action, information was collected and shared about state-of-the-art, ongoing studies, problems and future research needs, in the topics covered by the five above-mentioned Projects [1-3]. Based on the experience and knowledge gained from the in-depth review work carried out by WG2, several case studies were then conducted; they were presented during the Second General Meeting and the GPR 2014 conference [5, 6]. Furthermore, the extension of GPR application to railways track ballast assessment was demonstrated [7]. The WG2 identified reference test-sites, suitable to compare inspection procedures or to test GPR equipment. The IFSTTAR geophysical test site is an open-air laboratory including a large and deep area, filled with various materials arranged in horisontal compacted slices, separated by vertical interfaces and water-tighted in surface; several objects as pipes, polystyrene hollows, boulders and masonry are embedded in the field [4]. The IFSTTAR full-scale APT facility is an outdoor circular carousel dedicated to full-scale pavement experiments, consisting of a central tower and four long arms equipped with wheels, running on a circular test track [4]. Furthermore, the WG2 is building a database of available experimental results, which are at the disposal of WG3 Members to test their electromagnetic modeling/inversion/data-processing methods. Another interesting and promising WG2 initiative that has to be mentioned is the development of a Catalogue of

IEC SC15E: Report on liaison activities of CIGRÉ-SC15

DEFF Research Database (Denmark)

Henriksen, Mogens

2000-01-01

WG’s activities under CIGRÉ SC15:WG 15.01 - Fluid impregnated systems.WG 15.02 - Dielectric Liquids.WG 15.03 - Gas Insulation.WG 15.04 - Outdoor Insulation.WG 15.05 - Capacitors.WG 15.07 - Solid Insulating Materials for Rotating Machines.WG 15/33.08 - Insulation Monitoring and Life Estimation. WG...

77 FR 46147 - 57th Meeting: RTCA Special Committee 186, Automatic Dependent Surveillance Broadcast (ADS-B)

Science.gov (United States)

2012-08-02

... be held at RTCA, Inc., 1150 18th Street NW., Suite 910, MacIntosh-NBAA Room and Colson Board Room, Washington, DC 20036. FOR FURTHER INFORMATION CONTACT: The RTCA Secretariat, 1150 18th Street NW., Suite 910... MOPS--no report WG-4--Application Technical Requirements--Status [ssquf] Traffic Situation Awareness...

Preproghrelin Leu72Met polymorphism in obese Korean children.

Science.gov (United States)

Jo, Dae-Sun; Kim, Se-Lim; Kim, Sun-Young; Hwang, Pyoung Han; Lee, Kee-Hyoung; Lee, Dae-Yeol

2005-11-01

Ghrelin is a novel gut-brain peptide that has somatotropic, orexigenic, and adipogenic effects. We examined the preproghrelin Leu72Met polymorphism in 222 obese Korean children to determine whether it is associated with obesity. The frequencies of the Leu72Met polymorphism were 29.3% in obese, 32.3% in overweight, and 32.5% in lean Korean children. No significant difference was found between Met72 carrier and non-carrier obese children with respect to BMI, total body fat, serum triglycerides, total cholesterol, or LDL-cholesterol levels. Our data suggest that the preproghrelin Leu72Met polymorphism is not associated with obesity in children.

46 CFR 201.72 - Notice.

Science.gov (United States)

2010-10-01

... Formal Proceedings, Notice, Pleadings, Replies (Rule 7) § 201.72 Notice. Notice of any matter which may... Register in sufficient detail and in sufficient time to apprise interested persons of the nature of the...

49 CFR 27.72 - Boarding assistance for aircraft.

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Boarding assistance for aircraft. 27.72 Section 27... Specific Operating Administration Programs: Airports, Railroads, and Highways § 27.72 Boarding assistance... enplanements. (b) Airports shall, in cooperation with carriers serving the airports, provide boarding...

Mechanisms of stress-induced cellular HSP72 release: implications for exercise-induced increases in extracellular HSP72.

Science.gov (United States)

Lancaster, Graeme I; Febbraio, Mark A

2005-01-01

The heat shock proteins are a family of highly conserved proteins with critical roles in maintaining cellular homeostasis and in protecting the cell from stressful conditions. While the critical intracellular roles of heat shock proteins are undisputed, evidence suggests that the cell possess the necessary machinery to actively secrete specific heat shock proteins in response to cellular stress. In this review, we firstly discuss the evidence that physical exercise induces the release of heat shock protein 72 from specific tissues in humans. Importantly, it appears as though this release is the result of an active secretory process, as opposed to non-specific processes such as cell lysis. Next we discuss recent in vitro evidence that has identified a mechanistic basis for the observation that cellular stress induces the release of a specific subset of heat shock proteins. Importantly, while the classical protein secretory pathway does not seem to be involved in the stress-induced release of HSP72, we discuss the evidence that lipid-rafts and exosomes are important mediators of the stress-induced release of HSP72.

28 CFR 549.72 - Services provided without fees.

Science.gov (United States)

2010-07-01

... care; (f) Diagnosis or treatment of chronic infectious diseases; (g) Mental health care; or (h... Section 549.72 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT MEDICAL SERVICES Fees for Health Care Services § 549.72 Services provided without fees. We will not charge...

27 CFR 41.72 - Notice for smokeless tobacco.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Notice for smokeless tobacco. 41.72 Section 41.72 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO IMPORTATION OF TOBACCO PRODUCTS, CIGARETTE PAPERS...

48 CFR 846.302-72 - Frozen processed foods.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Frozen processed foods... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 846.302-72 Frozen processed foods. The contracting officer shall insert the clause at 852.246-72, Frozen processed foods, in solicitations and contracts for...

41 CFR 105-72.204 - Special award conditions.

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Special award conditions. 105-72.204 Section 105-72.204 Public Contracts and Property Management Federal Property Management... award conditions. If an applicant or recipient: (a) Has a history of poor performance, (b) Is not...

40 CFR 230.72 - Actions controlling the material after discharge.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Actions controlling the material after discharge. 230.72 Section 230.72 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN... Actions To Minimize Adverse Effects § 230.72 Actions controlling the material after discharge. The effects...

48 CFR 2052.209-72 - Contractor organizational conflicts of interest.

Science.gov (United States)

2010-10-01

... conflicts of interest. 2052.209-72 Section 2052.209-72 Federal Acquisition Regulations System NUCLEAR... Clauses 2052.209-72 Contractor organizational conflicts of interest. As prescribed at 2009.570-5(a) and..., contracts, and simplified acquisitions of the types described; 2009.570-4(b): Contractor Organizational...

48 CFR 552.211-72 - Reference to Specifications in Drawings.

Science.gov (United States)

2010-10-01

... Specifications in Drawings. 552.211-72 Section 552.211-72 Federal Acquisition Regulations System GENERAL SERVICES....211-72 Reference to Specifications in Drawings. As prescribed in 511.204(a), insert the following clause: References to Specifications in Drawings (FEB 1996) If military or other drawings are made a part...

41 CFR 102-72.40 - What are facility management delegations?

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What are facility management delegations? 102-72.40 Section 102-72.40 Public Contracts and Property Management Federal Property... AUTHORITY Delegation of Authority § 102-72.40 What are facility management delegations? Facility management...

40 CFR 72.73 - State issuance of Phase II permits.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false State issuance of Phase II permits. 72.73 Section 72.73 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Phase II Implementation § 72.73 State issuance of Phase II permits...

29 CFR 1919.72 - Annual examination of cranes.

Science.gov (United States)

2010-07-01

... 29 Labor 7 2010-07-01 2010-07-01 false Annual examination of cranes. 1919.72 Section 1919.72 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... examination of cranes. (a) In any year in which no quadrennial unit proof test is required, an examination...

9 CFR 72.5 - Area quarantined in Texas.

Science.gov (United States)

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Area quarantined in Texas. 72.5... AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS TEXAS (SPLENETIC) FEVER IN CATTLE § 72.5 Area quarantined in Texas. The area quarantined in Texas is the quarantined area...

Evaluation of six different groups of insecticides for the control of citrus psylla Diaphorina citri (Hemiptera: Psyllidae

Directory of Open Access Journals (Sweden)

Rakhmin Gul

2005-01-01

Full Text Available Studies on the efficacy of different insecticides against citrus psylla, Diaphorina citri (Hemiptera: Psyllidae were carried out at Agricultural Research Institute, Tarnab, Peshawar, Pakistan. Six insecticides viz. Actara 25 WG, (thiamethoxam Cascade 10 DC (Flufenoxuron, Match 050 EC (lufenuron, Thiodan 35 EC (endosulfan, Karate 2.5 EC (α-cyhalothrin, and Supracide 40 EC (methidathion, were tested for their effectiveness against D. citri. After first spray overall mean population of D. citri was 3.63, 4.75, 5.59, 6.66, 7.47, 8.11 per six inches tender shoot on Actara 25 WG, Cascade 10 DC, Match 050 EC, Thiodan 35 EC, Karate 2.5 EC and Supracide 40 EC treated plants respectively, while on control plants the population was 12.39. Similarly, after the second spray of each of the same insecticides the population of D. citri was 2.65, 4.23, 5.61, 6.41, 7.35 and 8.73 respectively. Where in controls there were 15.18 psyllids. Percent decrease of D. citri population in comparison to control after the first spray was highest in Actara 25 WG (72.20 followed by Cascade 10 DC (62.91, Match 050 EC (54.07, Thiodan 35 EC (47.61, Karate 2.5 EC (38.94 and Supracide 40 EC (35.74. After the second spray percent decrease over control recorded was highest in Actara 25 WG (83.54, followed by Cascade 10 DC (71.08, Match 050 EC (63.94, Thiodan 35 EC (60.79, Karate 2.5 EC (52.52 and Supracide 40 EC (45.62.

Eiroforum Meets at CERN

CERN Multimedia

2001-01-01

From left to right : Dr. J. Pamela, European Fusion Development Agreement (EFDA ), Associate Leader for JET (JET-EFDA), Dr. C. Carlile, Director-General Institut Laue-Langevin (ILL) Dr. A. Mitsos, Director-General of Research, European Commission , Prof. L. Maiani, Director-General (CERN), Dr. C. Cesarsky, Director-General European Southern Observatory (ESO), Prof. F. Kafatos, Director-General European Molecular Biology Laboratory (EMBL), Prof. W.G. Stirling, Director-General European Snchrotron Radiation Facility (ESRF), Dr.J.P. Poncelet, Director of Strategy and External Relations European Space Agency (ESA). Since the early 1950s, a number of powerful research laboratories which are used by an extensive network of scientists have been developed and deployed within Europe by European Intergovernmental Research Organisations (EIRO).This year, seven of these organisations have set up a collaboration group (EIROFORUM) with their top executives (Directors General or equivalent) as members. The most recent me...

10 CFR 455.72 - Scope of the grant.

Science.gov (United States)

2010-01-01

.... Such measures include, but are not necessarily limited to, those included in the definition of “energy... 10 Energy 3 2010-01-01 2010-01-01 false Scope of the grant. 455.72 Section 455.72 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION GRANT PROGRAMS FOR SCHOOLS AND HOSPITALS AND BUILDINGS OWNED BY...

New clinical validation method for automated sphygmomanometer: a proposal by Japan ISO-WG for sphygmomanometer standard.

Science.gov (United States)

Shirasaki, Osamu; Asou, Yosuke; Takahashi, Yukio

2007-12-01

Owing to fast or stepwise cuff deflation, or measuring at places other than the upper arm, the clinical accuracy of most recent automated sphygmomanometers (auto-BPMs) cannot be validated by one-arm simultaneous comparison, which would be the only accurate validation method based on auscultation. Two main alternative methods are provided by current standards, that is, two-arm simultaneous comparison (method 1) and one-arm sequential comparison (method 2); however, the accuracy of these validation methods might not be sufficient to compensate for the suspicious accuracy in lateral blood pressure (BP) differences (LD) and/or BP variations (BPV) between the device and reference readings. Thus, the Japan ISO-WG for sphygmomanometer standards has been studying a new method that might improve validation accuracy (method 3). The purpose of this study is to determine the appropriateness of method 3 by comparing immunity to LD and BPV with those of the current validation methods (methods 1 and 2). The validation accuracy of the above three methods was assessed in human participants [N=120, 45+/-15.3 years (mean+/-SD)]. An oscillometric automated monitor, Omron HEM-762, was used as the tested device. When compared with the others, methods 1 and 3 showed a smaller intra-individual standard deviation of device error (SD1), suggesting their higher reproducibility of validation. The SD1 by method 2 (P=0.004) significantly correlated with the participant's BP, supporting our hypothesis that the increased SD of device error by method 2 is at least partially caused by essential BPV. Method 3 showed a significantly (P=0.0044) smaller interparticipant SD of device error (SD2), suggesting its higher interparticipant consistency of validation. Among the methods of validation of the clinical accuracy of auto-BPMs, method 3, which showed the highest reproducibility and highest interparticipant consistency, can be proposed as being the most appropriate.

Lifetime measurements in N=Z 72Kr

Science.gov (United States)

Andreoiu, C.; Svensson, C. E.; Austin, R. A. E.; Carpenter, M. P.; Dashdorj, D.; Finlay, P.; Freeman, S. J.; Garrett, P. E.; Görgen, A.; Greene, J.; Grinyer, G. F.; Hyland, B.; Jenkins, D.; Johnston-Theasby, F.; Joshi, P.; Machiavelli, A. O.; Moore, F.; Mukherjee, G.; Phillips, A. A.; Reviol, W.; Sarantites, D. G.; Schumaker, M. A.; Seweryniak, D.; Smith, M. B.; Valiente-Dobón, J. J.; Wadsworth, R.

2006-07-01

High-spin states in the N=Z nucleus 72Kr have been populated in the 40Ca(40Ca, 2α)72Kr fusion-evaporation reaction at a beam energy of 165 MeV and using a thin isotopically enriched 40Ca target. The experiment, performed at Argonne National Laboratory close to Chicago, USA, employed the Gammasphere array for γ-ray detection coupled to the Microball array for charged particle detection. The previously observed bands in 72Kr were extended to a higher excitation energy of ~24 MeV and higher angular momentum of 30planck. Using the Doppler-shift attenuation method, the lifetimes of high-spin states were measured for the first time in order to investigate deformation changes associated with the g9/2 proton and neutron alignments in this N=Z nucleus. An excellent agreement with theoretical calculations including only standard t=1 np pairing was observed.

40 CFR 141.72 - Disinfection.

Science.gov (United States)

2010-07-01

... PRIMARY DRINKING WATER REGULATIONS Filtration and Disinfection § 141.72 Disinfection. A public water... the direct influence of surface water and provides filtration treatment must provide disinfection...) Disinfection requirements for public water systems which provide filtration. Each public water system that...

41 CFR 105-72.503 - Competition.

Science.gov (United States)

2010-07-01

... competitive advantage, contractors that develop or draft specifications, requirements, statements of work... (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services Administration 72-UNIFORM...

10 CFR 72.94 - Design basis external man-induced events.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Design basis external man-induced events. 72.94 Section 72... WASTE Siting Evaluation Factors § 72.94 Design basis external man-induced events. (a) The region must be examined for both past and present man-made facilities and activities that might endanger the proposed...

Climate Products and Services to Meet the Challenges of Extreme Events

Science.gov (United States)

McCalla, M. R.

2008-12-01

existing federal climate products and services and the needed federal climate products and services which will address these weather thresholds. Just as important, as we work to meet the needs, a robust education and outreach program is essential to take full advantage of new products, services and capabilities. To ascertain what climate products and services currently exist to address weather thresholds relative to surface transportation, what climate products and services are needed to address these weather thresholds, and how to bridge the gap between what is available and what is needed, the OFCM surveyed the federal meteorological community. Consistent with the extreme events highlighted in the IPCC report, the OFCM survey categorized the weather thresholds associated with surface transportation into the following extreme event areas: (a) excessive heat, (b) winter precipitation, (c) summer precipitation, (d) high winds, and (e) flooding and coastal inundation. The survey results, the gap analysis, as well as OFCM's planned, follow-on activities with additional categories (i.e., in addition to surface transportation) and weather thresholds will be shared with meeting participants. 1 The OFCM is an interdepartmental office established in response to Public Law 87-843 with the mission to ensure the effective use of federal meteorological resources by leading the systematic coordination of operational weather and climate requirements, products, services, and supporting research among the federal agencies. 2 http://www.climatescience.gov/Library/sap/sap4-7/final-report/sap4-7-final-ch1.pdf 3 http://www.gcrio.org/ipcc/ar4/wg1/faq/ar4wg1faq-3-3.pdf

Identification of the first multi-exonic WDR72 deletion in isolated amelogenesis imperfecta, and generation of a WDR72-specific copy number screening tool.

Science.gov (United States)

Hentschel, Julia; Tatun, Dana; Parkhomchuk, Dmitri; Kurth, Ingo; Schimmel, Bettina; Heinrich-Weltzien, Roswitha; Bertzbach, Sabine; Peters, Hartmut; Beetz, Christian

2016-09-15

Amelogenesis imperfecta (AI) is a clinically and genetically heterogeneous disorder of tooth development which is due to aberrant deposition or composition of enamel. Both syndromic and isolated forms exist; they may be inherited in an X-linked, autosomal recessive, or autosomal dominant manner. WDR72 is one of ten currently known genes for recessive isolated AI; nine WDR72 mutations affecting single nucleotides have been described to date. Based on whole exome sequencing in a large consanguineous AI pedigree, we obtained evidence for presence of a multi-exonic WDR72 deletion. A home-made multiplex ligation-dependent probe amplification assay was used to confirm the aberration, to narrow its extent, and to identify heterozygous carriers. Our study extends the mutational spectrum for WDR72 to include large deletions, and supports a relevance of the previously proposed loss-of-function mechanism. It also introduces an easy-to-use and highly sensitive tool for detecting WDR72 copy number alterations. Copyright © 2016. Published by Elsevier B.V.

Travel to France as Chief US Delegate at a meeting of International Standards Organization ISO/TC-85, ``Nuclear Technology``. Foreign trip report, March 17--March 26, 1994

Energy Technology Data Exchange (ETDEWEB)

Westfall, R.M.

1994-04-11

As overall US Advisor for ISO/TC-85, SC-5, Dr. Westfall met with (1) Work Group 1, ``Measurement Techniques for the Chemical and Physical Characterization of UF{sub 6}, UO{sub 2}, and Mixed Oxide,`` on Monday, March 21, (2) Work Group 5, ``Standardization of Measurement Methods for the Characterization of Solid and Solidified Waste Forms, and for the Corrosion of their Primary Containers,`` on Tuesday, March 22; and (3) the full Subcommittee-5 on Wednesday, March 23. The status of work by all seven work groups in SC-5 was reported. Those having to do with nuclear fuel transportation (WG-4: UF, Containers, WG-9: Cask Trunnions, and WG-10: Cask Confinement) either have approved standards or drafts at an advanced stage of development. These work group convenors were asked to maintain their membership and establish new work areas in the field of nuclear fuel packaging. Definition of scope for new work is to be done in coordination with the interested staff members of the International Atomic Energy Agency, Vienna, Austria. On Thursday, March 24, the Cogema-Marcoule Plant staff hosted the SC-5 members to technical tours of their nuclear fuel reprocessing and waste vitrification and storage facilities.

IEC Newsletter, No. 47, First Quarter 2014

Energy Technology Data Exchange (ETDEWEB)

NONE

2014-05-15

The ConvEx-3 (2013) evaluation meeting - the Fifth Meeting of the Inter-Agency Committee on Radiological and Nuclear Emergencies Working Group on Coordinated International Exercises (IACRNE-WG-CIE) - took place at IAEA Headquarters in Vienna from 11-12 February 2014. Representatives from the Moroccan authorities, members of the IACRNE Working Group on Coordinated International Exercises, exercise chief evaluators, and the chairperson of the National Competent Authority Coordination Group (NCACG) were invited and participated in the meeting. The objectives of the meeting were to evaluate the ConvEx-3 (2013) exercise, to review the draft Exercise Report, and to discuss exercise findings and conclusions. On the first day of the meeting (11 February), the exercise was evaluated by the host country Morocco and by chief evaluators of some international organizations and Member States. National objectives, findings, conclusions and recommendations for emergency preparedness and response improvements were presented and discussed. On the second day (12 February), the Lead Exercise Evaluator and chair of the ICARNE WG-CIE, presented the draft Exercise Report, and proposals for common findings, conclusions and recommendations based on the Chief Evaluator's reports were consolidated. It was also agreed that the revised draft Exercise Report will be distributed for comment and feedback to all chief evaluators who have submitted evaluation reports to the IAEA. The ConvEx-3 exercise was conducted by the Incident and Emergency Centre (IEC) on 20-21 November 2013. Fifty-nine Member States (including Morocco) and ten international organizations (including the IAEA) participated in the exercise.

IEC Newsletter, No. 47, First Quarter 2014

International Nuclear Information System (INIS)

2014-05-01

The ConvEx-3 (2013) evaluation meeting - the Fifth Meeting of the Inter-Agency Committee on Radiological and Nuclear Emergencies Working Group on Coordinated International Exercises (IACRNE-WG-CIE) - took place at IAEA Headquarters in Vienna from 11-12 February 2014. Representatives from the Moroccan authorities, members of the IACRNE Working Group on Coordinated International Exercises, exercise chief evaluators, and the chairperson of the National Competent Authority Coordination Group (NCACG) were invited and participated in the meeting. The objectives of the meeting were to evaluate the ConvEx-3 (2013) exercise, to review the draft Exercise Report, and to discuss exercise findings and conclusions. On the first day of the meeting (11 February), the exercise was evaluated by the host country Morocco and by chief evaluators of some international organizations and Member States. National objectives, findings, conclusions and recommendations for emergency preparedness and response improvements were presented and discussed. On the second day (12 February), the Lead Exercise Evaluator and chair of the ICARNE WG-CIE, presented the draft Exercise Report, and proposals for common findings, conclusions and recommendations based on the Chief Evaluator's reports were consolidated. It was also agreed that the revised draft Exercise Report will be distributed for comment and feedback to all chief evaluators who have submitted evaluation reports to the IAEA. The ConvEx-3 exercise was conducted by the Incident and Emergency Centre (IEC) on 20-21 November 2013. Fifty-nine Member States (including Morocco) and ten international organizations (including the IAEA) participated in the exercise

The role of European Federation of Clinical Chemistry and Laboratory Medicine Working Group for Preanalytical Phase in standardization and harmonization of the preanalytical phase in Europe

DEFF Research Database (Denmark)

Cornes, Michael P; Church, Stephen; van Dongen-Lases, Edmée

2016-01-01

Patient safety is a leading challenge in healthcare and from the laboratory perspective it is now well established that preanalytical errors are the major contributor to the overall rate of diagnostic and therapeutic errors. To address this, the European Federation of Clinical Chemistry and Labor......Patient safety is a leading challenge in healthcare and from the laboratory perspective it is now well established that preanalytical errors are the major contributor to the overall rate of diagnostic and therapeutic errors. To address this, the European Federation of Clinical Chemistry...... and Laboratory Medicine Working Group for Preanalytical Phase (EFLM WG-PRE) was established to lead in standardization and harmonization of preanalytical policies and practices at a European level. One of the key activities of the WG-PRE is the organization of the biennial EFLM-BD conference on the preanalytical...... summarises the work that has and will be done in these areas. The goal of this initiative is to ensure the EFLM WG-PRE produces work that meets the needs of the European laboratory medicine community. Progress made in the identified areas will be updated at the next preanalytical phase conference and show...

Division A Commission 31: Time

Science.gov (United States)

Hosokawa, Mizuhiko; Arias, Elisa Felicitas; Manchester, Richard; Tuckey, Philip; Matsakis, Demetrios; Zhang, Shougang; Zharov, Vladimir

2016-04-01

Time is an essential element of fundamental astronomy. In recent years there have been many time-related issues, in scientific and technological aspects as well as in conventions and definitions. At the Commission 31 (Time) business meeting at the XXIX General Assembly, recent progress and many topics, including Pulsar Time Scales WG and Future UTC WG activities, were reviewed and discussed. In this report, we will review the progress of these topics in the past three years. There are many remarkable topics, such as Time scales, Atomic clock development, Time transfer, Future UTC and future redefinition of the second. Among them, scientific highlights are the progress of pulsar time scales and the optical frequency standards. On the other hand, as the social convention, change in the definition of UTC and the second is important.

32 CFR 516.72 - Procedures.

Science.gov (United States)

2010-07-01

... RELATIONS LITIGATION Cooperation With the Office of Special Counsel § 516.72 Procedures. (a) Witnesses and... government agencies in the normal course of official business. Records constituting attorney work product... funding for travel, per diem and other necessary expenses related to the OSC investigation. These expenses...

Drosophila VAMP7 regulates Wingless intracellular trafficking.

Science.gov (United States)

Gao, Han; He, Fang; Lin, Xinhua; Wu, Yihui

2017-01-01

Drosophila Wingless (Wg) is a morphogen that determines cell fate during development. Previous studies have shown that endocytic pathways regulate Wg trafficking and signaling. Here, we showed that loss of vamp7, a gene required for vesicle fusion, dramatically increased Wg levels and decreased Wg signaling. Interestingly, we found that levels of Dally-like (Dlp), a glypican that can interact with Wg to suppress Wg signaling at the dorsoventral boundary of the Drosophila wing, were also increased in vamp7 mutant cells. Moreover, Wg puncta in Rab4-dependent recycling endosomes were Dlp positive. We hypothesize that VAMP7 is required for Wg intracellular trafficking and the accumulation of Wg in Rab4-dependent recycling endosomes might affect Wg signaling.

48 CFR 1352.237-72 - Security processing requirements-national security contracts.

Science.gov (United States)

2010-10-01

... requirements-national security contracts. 1352.237-72 Section 1352.237-72 Federal Acquisition Regulations... Provisions and Clauses 1352.237-72 Security processing requirements—national security contracts. As prescribed in 48 CFR 1337.110-70(d), use the following clause: Security Processing Requirements—National...

15 CFR 922.72 - Prohibited or otherwise regulated activities-Sanctuary-wide.

Science.gov (United States)

2010-01-01

... activities-Sanctuary-wide. 922.72 Section 922.72 Commerce and Foreign Trade Regulations Relating to Commerce... OCEAN AND COASTAL RESOURCE MANAGEMENT NATIONAL MARINE SANCTUARY PROGRAM REGULATIONS Channel Islands National Marine Sanctuary § 922.72 Prohibited or otherwise regulated activities—Sanctuary-wide. (a) Except...

Adsorption of phenol and 1-naphthol onto XC-72 carbon

Energy Technology Data Exchange (ETDEWEB)

Zuo, Liming; Yu, Shaoming; Cheng, Leilei; Du, Erling [hefei university of technology, Hefei (China)

2013-03-15

XC-72 carbon (XC-72) was characterized by SEM, XPS, N{sub 2} adsorption-desorption, particle size distribution analysis and potentiometric acid-base titration. The adsorption of phenol and 1-naphthol on XC-72 was studied as a function of contact time, pH, adsorbent content and temperature. The kinetic adsorption data were described well by the pseudo-second-order model. The adsorption isotherms of phenol were described well by Freundlich model, while the adsorption isotherms of 1-naphthol were fitted well by Langmuir model. The results demonstrated that XC-72 had much higher adsorption capacity for 1-naphthol than for phenol. The adsorption thermodynamic data were calculated from the temperature-dependent adsorption isotherms at T=293, 313 and 333 K, and the results indicated that the adsorption of phenol was an exothermic process, whereas the adsorption of 1-naphthol was an endothermic process. XC-72 is a suitable material for the preconcentration of phenol and 1-naphthol from large volumes of aqueous solutions.

27 CFR 72.21 - Personal property and carriers subject to seizure.

Science.gov (United States)

2010-04-01

... carriers subject to seizure. 72.21 Section 72.21 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO... SEIZED PERSONAL PROPERTY Seizures and Forfeitures § 72.21 Personal property and carriers subject to seizure. (a) Personal property may be seized by duly authorized ATF officers for forfeiture to the United...

Optimal Selective Harmonic Mitigation Technique on Variable DC Link Cascaded H-Bridge Converter to Meet Power Quality Standards

DEFF Research Database (Denmark)

Najjar, Mohammad; Moeini, Amirhossein; Dowlatabadi, Mohammadkazem Bakhshizadeh

2016-01-01

In this paper, the power quality standards such as IEC 61000-3-6, IEC 61000-2-12, EN 50160, and CIGRE WG 36-05 are fulfilled for single- and three-phase medium voltage applications by using Selective Harmonic Mitigation-PWM (SHM-PWM) in a Cascaded H-Bridge (CHB) converter. Furthermore, the ER G5/...

Sixth international workshop on linear colliders. Proceedings

Energy Technology Data Exchange (ETDEWEB)

Urakawa, Junji [ed.

1995-08-01

The sixth international workshop on linear colliders (LC95) was held by KEK at Tsukuba Center for Institute. In the workshop 8 parallel working group were organized: WG1 (beam sources and injection linacs), WG2 (damping rings and bunch compressors), WG3 (a: RF sources and structures, b: superconducting cavities, c: two beam accelerators), WG4 (beam dynamics in main linacs), WG5 (final focus and integration regions), WG6 (beam instrumentation), WG7 (overall parameters and construction techniques), WG8 (gamma-gamma collider and miscellaneous). This issue compiles materials which were used in the workshop. (J.P.N.).

Sixth international workshop on linear colliders. Proceedings

International Nuclear Information System (INIS)

Urakawa, Junji

1995-08-01

The sixth international workshop on linear colliders (LC95) was held by KEK at Tsukuba Center for Institute. In the workshop 8 parallel working group were organized: WG1 (beam sources and injection linacs), WG2 (damping rings and bunch compressors), WG3 (a: RF sources and structures, b: superconducting cavities, c: two beam accelerators), WG4 (beam dynamics in main linacs), WG5 (final focus and integration regions), WG6 (beam instrumentation), WG7 (overall parameters and construction techniques), WG8 (gamma-gamma collider and miscellaneous). This issue compiles materials which were used in the workshop. (J.P.N.)

27 CFR 41.72a - Notice for pipe tobacco.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Notice for pipe tobacco. 41.72a Section 41.72a Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO IMPORTATION OF TOBACCO PRODUCTS, CIGARETTE PAPERS AND TUBES...

48 CFR 1523.303-72 - Care of laboratory animals.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Care of laboratory animals... Material and Material Safety Data 1523.303-72 Care of laboratory animals. Contracting officers shall insert the clause at 1552.223-72, Care of Laboratory Animals, in all contracts involving the use of...

Comparative thoracic anatomy of the wild type and wingless (wg1cn1) mutant of Drosophila melanogaster (Diptera).

Science.gov (United States)

Fabian, Benjamin; Schneeberg, Katharina; Beutel, Rolf Georg

2016-11-01

Genetically modified organisms are crucial for our understanding of gene regulatory networks, physiological processes and ontogeny. With modern molecular genetic techniques allowing the rapid generation of different Drosophila melanogaster mutants, efficient in-depth morphological investigations become an important issue. Anatomical studies can elucidate the role of certain genes in developmental processes and point out which parts of gene regulatory networks are involved in evolutionary changes of morphological structures. The wingless mutation wg 1 of D. melanogaster was discovered more than 40 years ago. While early studies addressed the external phenotype of these mutants, the documentation of the internal organization was largely restricted to the prominent indirect flight muscles. We used SEM micrographs, histological serial sections, μ-computed tomography, CLSM and 3D reconstructions to study and document the thoracic skeletomuscular system of the wild type and mutant. A recently introduced nomenclature for the musculature of neopteran insects was applied to facilitate comparisons with closely or more distantly related taxa. The mutation is phenotypically mainly characterized by the absence of one or both wings and halteres. The wing is partly or entirely replaced by duplications of mesonotal structures, whereas the haltere and its associated muscles are completely absent on body sides showing the reduction. Both the direct and indirect mesothoracic flight muscles are affected by loss and reorientation of bundles or fibers. Our observations lead to the conclusion that the wingless mutation causes a homeotic transformation in the imaginal discs of wings and halteres with a direct effect on the development of skeletal structures and an indirect effect on the associated muscular system. Copyright © 2016 Elsevier Ltd. All rights reserved.

39 CFR 6.1 - Regular meetings, annual meeting.

Science.gov (United States)

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Regular meetings, annual meeting. 6.1 Section 6.1 Postal Service UNITED STATES POSTAL SERVICE THE BOARD OF GOVERNORS OF THE U.S. POSTAL SERVICE MEETINGS (ARTICLE VI) § 6.1 Regular meetings, annual meeting. The Board shall meet regularly on a schedule...

Noradrenaline increases the expression and release of Hsp72 by human neutrophils.

Science.gov (United States)

Giraldo, E; Multhoff, G; Ortega, E

2010-05-01

The blood concentration of extracellular 72kDa heat shock protein (eHsp72) increases under conditions of stress, including intense exercise. However, the signal(s), source(s), and secretory pathways in its release into the bloodstream have yet to be clarified. The aim of the present study was to evaluate the role of noradrenaline (NA) as a stress signal on the expression and release of Hsp72 by circulating neutrophils (as a source), all within a context of the immunophysiological regulation during exercise-induced stress in sedentary and healthy young (21-26years) women. The expression of Hsp72 on the surface of isolated neutrophils was determined by flow cytometry, and its release by cultured isolated neutrophils was determined by ELISA. Incubation with cmHsp70-FITC showed that neutrophils express Hsp72 on their surface under basal conditions. In addition, cultured isolated neutrophils (37 degrees C and 5% CO(2)) also released Hsp72 under basal conditions, with this release increasing from 10min to 24h in the absence of cell damage. NA at 10(-9)-10(-5)M doubled the percentage of neutrophils expressing Hsp72 after 60min and 24h incubation. NA also stimulated (by about 20%) the release of Hsp72 after 10min of incubation. (1) Hsp72 is expressed on the surface of isolated neutrophils under basal conditions, and this expression is augmented by NA. (2) Isolated neutrophils can also release Hsp72 under cultured basal conditions in the absence of cell death, and NA can increase this release. These results may contribute to confirming the hypothesis that NA can act as a "stress signal" for the increased eHsp72 in the context of exercise stress, with a role for neutrophils as a source for the expression and, to a lesser degree, the release of Hsp72 after activation by NA. Copyright 2010 Elsevier Inc. All rights reserved.

The structure of an E. coli tRNAfMet A1-U72 variant shows an unusual conformation of the A1-U72 base pair.

Science.gov (United States)

Monestier, Auriane; Aleksandrov, Alexey; Coureux, Pierre-Damien; Panvert, Michel; Mechulam, Yves; Schmitt, Emmanuelle

2017-05-01

Translation initiation in eukaryotes and archaea involves a methionylated initiator tRNA delivered to the ribosome in a ternary complex with e/aIF2 and GTP. Eukaryotic and archaeal initiator tRNAs contain a highly conserved A 1 -U 72 base pair at the top of the acceptor stem. The importance of this base pair to discriminate initiator tRNAs from elongator tRNAs has been established previously using genetics and biochemistry. However, no structural data illustrating how the A 1 -U 72 base pair participates in the accurate selection of the initiator tRNAs by the translation initiation systems are available. Here, we describe the crystal structure of a mutant E. coli initiator tRNA f Met A 1 -U 72 , aminoacylated with methionine, in which the C 1 :A 72 mismatch at the end of the tRNA acceptor stem has been changed to an A 1 -U 72 base pair. Sequence alignments show that the mutant E. coli tRNA is a good mimic of archaeal initiator tRNAs. The crystal structure, determined at 2.8 Å resolution, shows that the A 1 -U 72 pair adopts an unusual arrangement. A 1 is in a syn conformation and forms a single H-bond interaction with U 72 This interaction requires protonation of the N1 atom of A 1 Moreover, the 5' phosphoryl group folds back into the major groove of the acceptor stem and interacts with the N7 atom of G 2 A possible role of this unusual geometry of the A 1 -U 72 pair in the recognition of the initiator tRNA by its partners during eukaryotic and archaeal translation initiation is discussed. © 2017 Monestier et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

10 CFR 820.72 - Referral to the Attorney General.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Referral to the Attorney General. 820.72 Section 820.72... Referral to the Attorney General. If there is reason to believe a criminal violation of the Act or the DOE Nuclear Safety Requirements has occurred, DOE may refer the matter to the Attorney General of the United...

Linking pre-meeting communication to meeting effectiveness

NARCIS (Netherlands)

Allen, J.A.; Lehmann-Willenbrock, N.K.; Landowski, N.

2014-01-01

Purpose – The purpose of this paper is to investigate the importance of communication that occurs just before workplace meetings (i.e. pre-meeting talk). The paper explores how four specific types of pre-meeting talk (small talk, work talk, meeting preparatory talk, and shop talk) impact

Meetings and meeting modeling in smart surroundings

NARCIS (Netherlands)

op den Akker, Hendrikus J.A.; Heylen, Dirk K.J.; Nijholt, Antinus; Nishida, T.

2004-01-01

In this paper we survey our research on smart meeting rooms and its relevance for augmented reality meeting support and virtual reality generation of meetings in real-time or off-line. Intelligent real-time and off-line generation requires understanding of what is going on during a meeting. The

Heat and exercise acclimation increases intracellular levels of Hsp72 and inhibits exercise-induced increase in intracellular and plasma Hsp72 in humans.

Science.gov (United States)

Magalhães, Flávio de Castro; Amorim, Fabiano Trigueiro; Passos, Renata L Freitas; Fonseca, Michele Atalla; Oliveira, Kenya Paula Moreira; Lima, Milene Rodrigues Malheiros; Guimarães, Juliana Bohen; Ferreira-Júnior, João Batista; Martini, Angelo R P; Lima, Nilo R V; Soares, Danusa Dias; Oliveira, Edilamar Menezes; Rodrigues, Luiz Oswaldo Carneiro

2010-11-01

In order to verify the effects of heat and exercise acclimation (HA) on resting and exercise-induced expression of plasma and leukocyte heat shock protein 72 (Hsp72) in humans, nine healthy young male volunteers (25.0 ± 0.7 years; 80.5 ± 2.0 kg; 180 ± 2 cm, mean ± SE) exercised for 60 min in a hot, dry environment (40 ± 0°C and 45 ± 0% relative humidity) for 11 days. The protocol consisted of running on a treadmill using a controlled hyperthermia technique in which the work rate was adjusted to elevate the rectal temperature by 1°C in 30 min and maintain it elevated for another 30 min. Before and after the HA, the volunteers performed a heat stress test (HST) at 50% of their individual maximal power output for 90 min in the same environment. Blood was drawn before (REST), immediately after (POST) and 1 h after (1 h POST) HST, and plasma and leukocytes were separated and stored. Subjects showed expected adaptations to HA: reduced exercise rectal and mean skin temperatures and heart rate, and augmented sweat rate and exercise tolerance. In HST1, plasma Hsp72 increased from REST to POST and then returned to resting values 1 h POST (REST: 1.11 ± 0.07, POST: 1.48 ± 0.10, 1 h POST: 1.22 ± 0.11 ng mL(-1); p  0.05). HA increased resting levels of intracellular Hsp72 (HST1: 1 ± 0.02 and HST2: 4.2 ± 1.2 density units, p  0.05). Regression analysis showed that the lower the pre-exercise expression of intracellular Hsp72, the higher the exercise-induced increase (R = -0.85, p < 0.05). In conclusion, HA increased resting leukocyte Hsp72 levels and inhibited exercise-induced expression. This intracellular adaptation probably induces thermotolerance. In addition, the non-increase in plasma Hsp72 after HA may be related to lower stress at the cellular level in the acclimated individuals.

Meetings and Meeting Modeling in Smart Environments

NARCIS (Netherlands)

Nijholt, Antinus; op den Akker, Hendrikus J.A.; Heylen, Dirk K.J.

In this paper we survey our research on smart meeting rooms and its relevance for augmented reality meeting support and virtual reality generation of meetings in real time or off-line. The research reported here forms part of the European 5th and 6th framework programme projects multi-modal meeting

Directors General of Europe's research organisations at the EIROforum meeting, CERN 24/10/2001

CERN Multimedia

BRICE M.

2001-01-01

from left to right: Dr.J. Pamela, EFDA (European Fusion Development Agreement) Associate Leader for JET ( JET-EFDA) Dr. C. Carlile, DG Institut Laue-Langevin (ILL) Dr. A. Mitsos, DG Research, European Commission Prof. L. Maiani, DG CERN Dr. C. Cesarsky, DG European Southern Observatory (ESO) Prof. F. Kafatos, DG European Molecular Biology Laboratory (EMBL) Prof. W.G. Stirling, DG European Snchrotron Radiation Facility (ESRF) Dr.J.P. Poncelet, Director of Strategy and External Relations ESA (European Space Agency)

Crystal Structure of the Human Symplekin-Ssu72-CTD Phosphopeptide Complex

Energy Technology Data Exchange (ETDEWEB)

K Xiang; T Nigaike; S Xiang; T Kilic; M Beh; J Manley; L Tong

2011-12-31

Symplekin (Pta1 in yeast) is a scaffold in the large protein complex that is required for 3'-end cleavage and polyadenylation of eukaryotic messenger RNA precursors (pre-mRNAs); it also participates in transcription initiation and termination by RNA polymerase II (Pol II). Symplekin mediates interactions between many different proteins in this machinery, although the molecular basis for its function is not known. Here we report the crystal structure at 2.4 {angstrom} resolution of the amino-terminal domain (residues 30-340) of human symplekin in a ternary complex with the Pol II carboxy-terminal domain (CTD) Ser5 phosphatase Ssu72 and a CTD Ser5 phosphopeptide. The N-terminal domain of symplekin has the ARM or HEAT fold, with seven pairs of antiparallel {alpha}-helices arranged in the shape of an arc. The structure of Ssu72 has some similarity to that of low-molecular-mass phosphotyrosine protein phosphatase, although Ssu72 has a unique active-site landscape as well as extra structural features at the C terminus that are important for interaction with symplekin. Ssu72 is bound to the concave face of symplekin, and engineered mutations in this interface can abolish interactions between the two proteins. The CTD peptide is bound in the active site of Ssu72, with the pSer5-Pro6 peptide bond in the cis configuration, which contrasts with all other known CTD peptide conformations. Although the active site of Ssu72 is about 25 {angstrom} from the interface with symplekin, we found that the symplekin N-terminal domain stimulates Ssu72 CTD phosphatase activity in vitro. Furthermore, the N-terminal domain of symplekin inhibits polyadenylation in vitro, but only when coupled to transcription. Because catalytically active Ssu72 overcomes this inhibition, our results show a role for mammalian Ssu72 in transcription-coupled pre-mRNA 3'-end processing.

48 CFR 552.219-72 - Preparation, Submission, and Negotiation of Subcontracting Plans.

Science.gov (United States)

2010-10-01

..., and Negotiation of Subcontracting Plans. 552.219-72 Section 552.219-72 Federal Acquisition Regulations... Text of Provisions and Clauses 552.219-72 Preparation, Submission, and Negotiation of Subcontracting... Negotiation of Subcontracting Plans (JUN 2005) (a) An offeror, other than a small business concern, submitting...

Heat shock protein 72: release and biological significance during exercise.

Science.gov (United States)

Whitham, Martin; Fortes, Matthew Benjamin

2008-01-01

The cumulative stressors of exercise manifest themselves at a cellular level by threatening the protein homeostasis of the cell. In these conditions, Heat Shock Proteins (HSP) are synthesised to chaperone mis-folded and denatured proteins. As such, the intracellular HSP response is thought to aid cell survival in the face of otherwise lethal cellular stress. Recently, the inducible isoform of the 70 Kda heat shock protein family, Hsp72 has been detected in the extracellular environment. Furthermore, the release of this protein into the circulation has been shown to occur in response to a range of exercise bouts. The present review summarises the current research on the exercise Hsp72 response, the possible mediators and mechanisms of extracellular (e)Hsp72 release, and the possible biological significance of this systemic response. In particular, the possible role of eHsp72 in the modulation of immunity during exercise is discussed.

INFCE Working Group 2 meeting IAEA Headquarters, Vienna 12-13 February 1979

International Nuclear Information System (INIS)

1979-02-01

Sub-group 1A/2A reported that revised drafts of the first four chapters of their report, covering base forecasts, fuel cycle scenarios, calculational methods, and fuel cycle requirements had been agreed, and that the contents of chapter V had been defined. Sub-group 2B also reported the distribution of draft versions of the first four chapters, with a final chapter on safeguards and non-proliferation yet to be prepared. A modified outline for the final report of WG.2 was discussed, and a time table was agreed upon for its preparation

Dosimetry Modeling for Focal Low-Dose-Rate Prostate Brachytherapy

Energy Technology Data Exchange (ETDEWEB)

Al-Qaisieh, Bashar [Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds (United Kingdom); Mason, Josh, E-mail: joshua.mason@nhs.net [Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds (United Kingdom); Bownes, Peter; Henry, Ann [Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds (United Kingdom); Dickinson, Louise [Division of Surgery and Interventional Science, University College London, London (United Kingdom); Department of Radiology, Northwick Park Hospital, London North West NHS Trust, London (United Kingdom); Ahmed, Hashim U. [Division of Surgery and Interventional Science, University College London, London (United Kingdom); University College London Hospital, London (United Kingdom); Emberton, Mark [University College London Hospital, London (United Kingdom); Langley, Stephen [St Luke' s Cancer Centre, Guildford (United Kingdom)

2015-07-15

Purpose: Focal brachytherapy targeted to an individual lesion(s) within the prostate may reduce side effects experienced with whole-gland brachytherapy. The outcomes of a consensus meeting on focal prostate brachytherapy were used to investigate optimal dosimetry of focal low-dose-rate (LDR) prostate brachytherapy targeted using multiparametric magnetic resonance imaging (mp-MRI) and transperineal template prostate mapping (TPM) biopsy, including the effects of random and systematic seed displacements and interseed attenuation (ISA). Methods and Materials: Nine patients were selected according to clinical characteristics and concordance of TPM and mp-MRI. Retrospectively, 3 treatment plans were analyzed for each case: whole-gland (WG), hemi-gland (hemi), and ultra-focal (UF) plans, with 145-Gy prescription dose and identical dose constraints for each plan. Plan robustness to seed displacement and ISA were assessed using Monte Carlo simulations. Results: WG plans used a mean 28 needles and 81 seeds, hemi plans used 17 needles and 56 seeds, and UF plans used 12 needles and 25 seeds. Mean D90 (minimum dose received by 90% of the target) and V100 (percentage of the target that receives 100% dose) values were 181.3 Gy and 99.8% for the prostate in WG plans, 195.7 Gy and 97.8% for the hemi-prostate in hemi plans, and 218.3 Gy and 99.8% for the focal target in UF plans. Mean urethra D10 was 205.9 Gy, 191.4 Gy, and 92.4 Gy in WG, hemi, and UF plans, respectively. Mean rectum D2 cm{sup 3} was 107.5 Gy, 77.0 Gy, and 42.7 Gy in WG, hemi, and UF plans, respectively. Focal plans were more sensitive to seed displacement errors: random shifts with a standard deviation of 4 mm reduced mean target D90 by 14.0%, 20.5%, and 32.0% for WG, hemi, and UF plans, respectively. ISA has a similar impact on dose-volume histogram parameters for all plan types. Conclusions: Treatment planning for focal LDR brachytherapy is feasible. Dose constraints are easily met with a notable

Field Efficiency Trial of 72% Streptomycin against Konjac Bacterial Soft Rot

Institute of Scientific and Technical Information of China (English)

Huang; Yongsheng; Li; Xiaojun; Zhu; Shijin; Ma; Yongsheng; Wang; Li

2014-01-01

72% Streptomycin soluble powder was used to control konjac bacterial soft rot in the study. The control efficiency and yield of different treatments were investigated,and the benefit was analyzed. The control scheme against konjac bacterial soft rot was as follows: spraying 72% atreptomycinon twice on rotation fields after all the seedlings were strong and uniform,or irrigating roots with 72% atreptomycinon once and spraying twice on continuous cropping fields.

48 CFR 301.607-72 - Applicability.

Science.gov (United States)

2010-10-01

... ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and Responsibilities 301.607-72 Applicability. (a) The FAC-P/PM certification prerequisites and continuous learning requirements apply to all HHS employees who seek to obtain a FAC-P/PM certification. Although obtaining a FAC-P/PM certification...

36 CFR 72.30 - General requirements.

Science.gov (United States)

2010-07-01

... PARK AND RECREATION RECOVERY ACT OF 1978 Grants for Recovery Action Program Development, Rehabilitation and Innovation § 72.30 General requirements. Applicants must have an approved Recovery Action Program on file with the appropriate NPS Regional Office prior to applying for Rehabilitation or Innovation...

Pt/XC-72 catalysts coated with nitrogen-doped carbon (Pt/XC-72@C–N) for methanol electro-oxidation

Energy Technology Data Exchange (ETDEWEB)

Cao, Jun; Chu, Yuanyuan; Tan, Xiaoyao, E-mail: cestanxy@aliyun.com

2014-03-01

Pt/XC-72 catalysts coated with N-doped carbon (denoted as Pt/XC-72@C–N) for the electro-oxidation of methanol are prepared through a combined microwave-assisted polyol with in-situ carbonization of N-doped carbon coating process using polyvinylpyrrolidone (PVP), 1-vinyl-3-ethylimidazolium nitrate (VEIN) or 1-ethyl-3-methylimidazolium dicyanamide (EMID) ionic liquid as the N-doped carbon precursor. X-ray diffraction, energy dispersive of X-ray, transmission electron microscopy, X-ray photoelectron spectroscopy, cyclic voltammograms and accelerated aging test techniques are applied to characterize the structure and the electro-catalytic activity of the catalysts. The results show that the Pt particles with the average size of around 2.5 nm are highly dispersed in face-centered cubic crystal structure in the carbon support. The structure of the N-doped carbon coating precursor has considerable influence on the electro-catalytic performance of the catalysts. The resultant catalyst with EMID ionic liquid as the N-doped carbon source exhibits 115.9 m{sup 2} g{sup −1}Pt electrochemical surface area (ESA) and 0.66 A mg{sup −1}Pt catalytic activity towards the electro-oxidation of methanol, which are 1.37 times the ESA and 1.35 times the catalytic activity of the PVP-derived catalyst, and 2.02 times the electrochemical surface area and 1.94 times the catalytic activity of the VEIN-derived catalyst. The appropriate amount of the EMID ionic liquid used in the catalyst synthesis process is around 10 uL for 100 mg XC-72 support so as to obtain the highest electro-catalytic activity. - Highlights: • N-doped carbon coated Pt/C catalyst is prepared for methanol electro-oxidation. • Pt/XC-72@C–N exhibits excellent electrocatalytic activity over uncoated catalysts. • Ionic liquid with anionic cyano groups is most suitable as N-doped carbon precursor. • The appropriate amount of ionic liquid for coating is around 10 μL for 100 mg carbon.

Preproghrelin Leu72Met polymorphism is not associated with type 2 diabetes mellitus.

Science.gov (United States)

Kim, Sun-Young; Jo, Dae-Sun; Hwang, Pyoung Han; Park, Ji Hyun; Park, Sung Kwang; Yi, Ho Keun; Lee, Dae-Yeol

2006-03-01

Ghrelin is a novel gut-brain peptide, which exerts somatotropic, orexigenic, and adipogenic effects. Genetic variants of ghrelin have been associated with both obesity and insulin metabolism. In this study, we determined a role of preproghrelin Leu72Met polymorphism on type 2 diabetes mellitus and its relationship to variables studied. Genotypes were assessed by polymerase chain reaction. Frequencies of the Leu72Met polymorphism were found to be 35.4% in the type 2 diabetic patients and 32.5% in the normal controls. The Leu72Met polymorphism was not associated with hypertension, macroangiopathy, retinopathy, serum cholesterol, triglyceride, blood urea nitrogen, HbA(1c), lipoprotein (a), fasting insulin, or 24-hour urinary protein levels in the type 2 diabetic group. However, the Leu72Met polymorphism was clearly associated with serum creatinine levels in the diabetic group, as the Met72 carriers exhibited lower serum creatinine levels than the Met72 noncarriers. Our data indicate that the preproghrelin Leu72Met polymorphism is not associated with type 2 diabetes mellitus. However, the Leu72Met polymorphism is associated with serum creatinine levels. These data suggest that Met72 carrier status may be a predictable marker for diabetic nephropathy or renal impairment in type 2 diabetes mellitus.

48 CFR 852.271-72 - Time spent by counselee in counseling process.

Science.gov (United States)

2010-10-01

... counseling process. 852.271-72 Section 852.271-72 Federal Acquisition Regulations System DEPARTMENT OF... Clauses 852.271-72 Time spent by counselee in counseling process. As prescribed in 871.212, insert the following clause: Time Spent by Counselee in Counseling Process (APR 1984) The contractor agrees that no...

36 CFR 72.12 - Assessment of needs, problems and issues.

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2010-07-01

... Issues. Management issues deal with operation of the park and recreation system. Information should... and issues. 72.12 Section 72.12 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT... Assessment of needs, problems and issues. The Action Program should begin with an Assessment describing the...

48 CFR 811.104-72 - Limited application of brand name or equal.

Science.gov (United States)

2010-10-01

... brand name or equal. 811.104-72 Section 811.104-72 Federal Acquisition Regulations System DEPARTMENT OF... Requirements Documents 811.104-72 Limited application of brand name or equal. If the contracting officer determines that the clause at 852.211-73, Brand name or equal, applies to only certain line items of a...

The G72/G30 gene complex and cognitive abnormalities in schizophrenia.

Science.gov (United States)

Goldberg, Terry E; Straub, Richard E; Callicott, Joseph H; Hariri, Ahmad; Mattay, Venkata S; Bigelow, Llewellyn; Coppola, Richard; Egan, Michael F; Weinberger, Daniel R

2006-09-01

A recently discovered gene complex, G72/G30 (hereafter G72, but now termed DAOA), was found to be associated with schizophrenia and with bipolar disorder, possibly because of an indirect effect on NMDA neurotransmission. In principle, if G72 increases risk for psychosis by this mechanism, it might impact with greater penetrance those cortically based cognitive and neurophysiological functions associated with NMDA signaling. We performed two independent family-based association studies (one sample contained more than 200 families and the other more than 65) of multiple SNPs in the G72 region and of multiple SNPs in the gene for D-amino acid oxidase (DAAO), which may be modulated by G72. We examined the relationship between select cognitive measures in attention, working memory, and episodic memory and a restricted set of G72 SNPs in over 600 normal controls, schizophrenic patients, and their nonpsychotic siblings using mixed model ANOVAs. We also determined genotype effects on neurophysiology measures in normal controls using the fMRI BOLD response obtained during activation procedures involving either episodic memory or working memory. There were no significant single G72 SNP associations and clinical diagnosis in either sample, though one approached significance (p=0.06). Diagnosis by genotype interaction effects for G72 SNP 10 were significant for cognitive variables assessing working memory and attention (p=0.05), and at the trend level for episodic memory, such that in the schizophrenia group an exaggerated allele load effect in the predicted directions was observed. In the fMRI paradigms, a strong effect of G72 SNP 10 genotype was observed on BOLD activation in the hippocampus during the episodic memory paradigm. Tests of association with DAAO were consistently nonsignificant. We present evidence that SNP variations in the G72 gene region increase risk of cognitive impairment in schizophrenia. SNP variations were not strongly associated with clinical diagnosis

Shape determination in Coulomb excitation of $^{72}$Kr

CERN Multimedia

Reiter, P; Kruecken, R; Paul, E S; Wadsworth, R; Heenen, P

Nuclei with oblate shapes at low spins are very special in nature because of their rarity. Both theoretical and experimental shape co-existence studies in the mass 70 region for near proton drip-line nuclei suggest $^{72}$Kr to be the unique case with oblate low-lying and prolate high-lying levels. However, there is no direct experimental evidence in the literature to date for the oblate nature predicted for the first 2$^+$ state in $^{72}$Kr. We propose to determine the sign of the spectroscopic quadrupole moment of this state via the re-orientation effect in a low-energy Coulomb excitation measurement. In the inelastic excitation of the 2$^+$ state in $^{72}$Kr beam of 3.1 MeV/u with an intensity of 800 pps at REX-ISOLDE impinging on $^{104}$Pd target, the re-orientation effect plays a significant role. The cross section measurement for the 2$^+$ state should thus allow the model-independent determination of the sign of the quadrupole moment unambiguously and will shed light on the co-existing prolate and o...

Cat exposure induces both intra- and extracellular Hsp72: the role of adrenal hormones.

Science.gov (United States)

Fleshner, Monika; Campisi, Jay; Amiri, Leila; Diamond, David M

2004-10-01

Heat-shock proteins (Hsp) play an important role in stress physiology. Exposure to a variety of stressors will induce intracellular Hsp72, and this induction is believed to be beneficial for cell survival. In contrast, Hsp72 released during stress (extracellular Hsp72; eHsp72) activates pro-inflammatory responses. Clearly, physical stressors such as heat, cold, H(2)O(2), intense exercise and tail shock will induce both intra- and extracellular Hsp72. The current study tested whether a psychological stressor, cat exposure, would also trigger this response. In addition, the potential role of adrenal hormones in the Hsp72 response was examined. Adult, male Sprague Dawley rats were either adrenalectomized (ADX) or sham operated. Ten days post-recovery, rats were exposed to either a cat with no physical contact or control procedures (n = 5-6/group) for 2 h. Levels of intracellular Hsp72 were measured in the brain (frontal cortex, hippocampus, hypothalamus, dorsal vagal complex) and pituitary (ELISA). Levels of eHsp72 (ELISA) and corticosterone (RIA) were measured from serum obtained at the end of the 2-h stress period. Rats that were exposed to a cat had elevated intracellular Hsp72 in hypothalamus and dorsal vagal complex, and elevated eHsp72 and corticosterone in serum. Both the intra- and extracellular Hsp72 responses were blocked or attenuated by ADX. This study demonstrates that cat exposure can stimulate the Hsp72 response and that adrenal hormones contribute to this response.

37 CFR 2.72 - Amendments to description or drawing of the mark.

Science.gov (United States)

2010-07-01

... drawing of the mark. 2.72 Section 2.72 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND....72 Amendments to description or drawing of the mark. (a) In an application based on use in commerce under section 1(a) of the Act, the applicant may amend the description or drawing of the mark only if...

10 CFR 51.72 - Supplement to draft environmental impact statement.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Supplement to draft environmental impact statement. 51.72... Implementing Section 102(2) Environmental Impact Statements § 51.72 Supplement to draft environmental impact statement. (a) The NRC staff will prepare a supplement to a draft environmental impact statement for which a...

Characterization and biodistribution of recombinant and recombinant/chimeric constructs of monoclonal antibody B72.3

International Nuclear Information System (INIS)

Colcher, D.; Milenic, D.; Roselli, M.

1989-01-01

Radiolabeled B72.3 has been administered both i.v. and i.p. in patients with colorectal and ovarian cancer as well as other carcinomas and has been shown to selectively bind to approximately 70-80% of metastatic lesions. Greater than 50% of the patients that have been treated with B72.3 have developed an immunological response to murine IgG after a single injection. In an attempt to minimize the immune response of these patients to the administered murine monoclonal antibody, we developed a recombinant form of the murine B72.3 as well as a recombinant/chimeric antibody, using the variable regions of the murine B72.3 and human heavy chain (gamma 4) and light chain (kappa) constant regions. We report here that both the recombinant B72.3 [rB72.3] and the recombinant/chimeric B72.3 [cB72.3(gamma 4)] IgGs maintain the tissue binding and idiotypic specificity of the native murine IgG. The native B72.3, rB72.3, and cB72.3(gamma 4) IgGs were radiolabeled and the biodistribution of these IgGs was studied in athymic mice bearing human colon carcinoma xenografts (LS-174T). Differences were observed between the cB72.3(gamma 4) and the native B72.3 in the percentage of injected dose/g that localized in the tumor. The somewhat lower absolute amounts of the cB72.3(gamma 4) in the tumor are mostly likely due to the observed more rapid clearance from the blood and body of the mouse as compared to the native B72.3 and rB72.3. All three forms [native B72.3, rB72.3, and cB72.3(gamma 4)] of the IgG, however, were able to localize the colon tumor with similar radiolocalization indices [percentage of injected dose/g in tumor divided by the percentage of injected dose/g in normal tissue

Performance of novel vs traditional insecticides for the control of amrascs biguttula biguttula (homoptera, cicadellidae) on cotton

International Nuclear Information System (INIS)

Karar, H.; Babar, T.K.; Shahzad, F.; Saleem, M.; Ali, A.; Akram, M.

2013-01-01

Amrasca biguttula biguttula (ishida) can reduce the yield of cotton approximately 25%. no potential predators have been recorded in the field for its control. to overcome this pest insecticides play significant role in the improvement of crop yields all over the world during the last four to five decades. to save the crop from this notorious pest, ten formulations of insecticides viz., acephate 75sp (acephate) at the rate 625g, imidacloprid 25wp (imidacloprid) at the rate188g, thiamethaxim 25wg (actara) at the rate 60g, imidacloprid 70wg (confidor) at the rate 43g, dimethoat e 40ec (sanitox) at the rate 1000 ml, nytonpyron 10sl (pyramid) at the rate 500ml, lambdacyhlothrin 2.5e (kango) at the rate 825 ml, thiachloprid 480sc (talent) at the rate 63 ml, imidacloprid 25sl (confidor) at the rate 500ml, and diafenthiuron 500sc (polo), at the rate 500ml, per hectare were sprayed in the field having maximum population of nymphs and adults of jassid at cotton research station, multan on cotton variety bt-886 in the month of july, 2011 and 2012. the maximum mortality of Jassid was observed in those treatments, where acephate was applied with 79, 72, 65 mortality, nytonpyron with 69, 63, 55 and imidacloprid 68, 63, 57 percent mortality after 24, 72 and 168 h of spray. minimum mortality of jassid was observed in the treatments where talent was applied having 25, 17 and 16 percent mortality 24, 72 and 168 h after spray. By the application of acephate, pyramid and confidor 25sl on cotton crop the yield can be increased. (author)

78 FR 2961 - Sunshine Act Meeting-Closed Meeting

Science.gov (United States)

2013-01-15

... COMMODITY FUTURES TRADING COMMISSION Sunshine Act Meeting--Closed Meeting The following notice of a closed meeting is published pursuant to the provisions of the Government in the Sunshine Act, Public Law 94- 409, 5 U.S.C. 552b. AGENCY HOLDING THE MEETING: Commodity Futures Trading Commission. TIME...

78 FR 6306 - Sunshine Act Meeting-Closed Meeting

Science.gov (United States)

2013-01-30

... COMMODITY FUTURES TRADING COMMISSION Sunshine Act Meeting--Closed Meeting The following notice of a closed meeting is published pursuant to the provisions of the Government in the Sunshine Act, Public Law 94- 409, 5 U.S.C. 552b. AGENCY HOLDING THE MEETING: Commodity Futures Trading Commission. TIME...

7 CFR 3560.72 - Loan closing.

Science.gov (United States)

2010-01-01

... DIRECT MULTI-FAMILY HOUSING LOANS AND GRANTS Direct Loan and Grant Origination § 3560.72 Loan closing. (a... all cases, the borrower must: (1) Provide evidence that an Agency-approved accounting system is in... cost of the work performed in connection with the construction contract in accordance with 7 CFR part...

Use of monoclonal antibody B72.3 in the management of gynecologic malignancies

International Nuclear Information System (INIS)

Simpson, J.; Schlom, J.

1988-01-01

Monoclonal antibodies are currently used in the diagnosis of gynecologic malignancies by way of immunohistochemical assays, serum assays, and in situ radiolocalization of carcinoma lesions. Among them is MAb B72.3, generated against a human tumor-associated antigen (TAG-72). Using immunohistochemical techniques, MAb B72.3 has shown reactivity with 100 percent of common epithelial ovarian carcinomas and endometrial carcinomas and non-reactivity with normal adult tissues, with the exception of normal secretory endometrium. B72.3 appears to be a valuable immunocytologic adjunct, with greater than 90 percent of effusions and fine-needle aspiration biopsies from gynecologic carcinomas showing reactivity. Using a serum assay developed to detect the presence of the TAG-72 antigen, 48 percent of patients with ovarian carcinoma demonstrated TAG-72-positive sera versus 1 percent of control sera. 131 I-labeled MAb B72.3 IgG and gamma scanning have been used for the in situ detection of metastatic carcinoma. Twelve of 15 patients with ovarian carcinoma showed positive gamma scans, and approximately 80 percent of the lesions demonstrated specific localization of the antibody. These studies indicate the potential utility of MAb B72.3 in the diagnosis of gynecologic carcinoma. 57 references

Global patterns of phytoplankton dynamics in coastal ecosystems

Science.gov (United States)

Paerl, H.; Yin, Kedong; Cloern, J.

2011-01-01

Scientific Committee on Ocean Research Working Group 137 Meeting; Hangzhou, China, 17-21 October 2010; Phytoplankton biomass and community structure have undergone dramatic changes in coastal ecosystems over the past several decades in response to climate variability and human disturbance. These changes have short- and long-term impacts on global carbon and nutrient cycling, food web structure and productivity, and coastal ecosystem services. There is a need to identify the underlying processes and measure the rates at which they alter coastal ecosystems on a global scale. Hence, the Scientific Committee on Ocean Research (SCOR) formed Working Group 137 (WG 137), "Global Patterns of Phytoplankton Dynamics in Coastal Ecosystems: A Comparative Analysis of Time Series Observations" (http://wg137.net/). This group evolved from a 2007 AGU-sponsored Chapman Conference entitled "Long Time-Series Observations in Coastal Ecosystems: Comparative Analyses of Phytoplankton Dynamics on Regional to Global Scales.".

49 CFR 1018.72 - Referral to the Department of Justice.

Science.gov (United States)

2010-10-01

... 49 Transportation 8 2010-10-01 2010-10-01 false Referral to the Department of Justice. 1018.72... Claim § 1018.72 Referral to the Department of Justice. (a) Claims for which the gross original amount is... Justice, Washington, DC 20530. Claims for which the gross original amount is $500,000 or less must be...

27 CFR 72.23 - Type and conditions of cost bond.

Science.gov (United States)

2010-04-01

... PROPERTY Seizures and Forfeitures § 72.23 Type and conditions of cost bond. The cost bond delivered by a claimant to effect removal of the forfeiture status of the property or carrier claimed to the jurisdiction... individual sureties the claimant may deposit collateral as provided in § 72.25. The cost bond shall be...

36 CFR 72.10 - General requirements.

Science.gov (United States)

2010-07-01

..., Iowa, Kansas, Missouri, Montana, Nebraska, North Dakota, South Dakota, Utah, and Wyoming. Pacific... PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.10 General requirements... Recreation Act of 1978, Pub. L. 95-625, (16 U.S.C. 2506); sec. 2 of Reorganization Plan No. 3 of 1950 (64...

Compensation of the AKT signaling by ERK signaling in transgenic mice hearts overexpressing TRIM72

Energy Technology Data Exchange (ETDEWEB)

Ham, Young-Mi, E-mail: youngmi_ham@hms.harvard.edu [College of Life Science and Biotechnology, Korea University, Seoul (Korea, Republic of); Department of Cell Biology, Harvard Medical School, Boston, MA 02115 (United States); Mahoney, Sarah Jane [Department of Cell Biology, Harvard Medical School, Boston, MA 02115 (United States)

2013-06-10

The AKT and ERK signaling pathways are known to be involved in cell hypertrophy, proliferation, survival and differentiation. Although there is evidence for crosstalk between these two signaling pathways in cellulo, there is less evidence for cross talk in vivo. Here, we show that crosstalk between AKT and ERK signaling in the hearts of TRIM72-overexpressing transgenic mice (TRIM72-Tg) with alpha-MHC promoter regulates and maintains their heart size. TRIM72, a heart- and skeletal muscle-specific protein, downregulates AKT-mTOR signaling via IRS-1 degradation and reduces the size of rat cardiomyocytes and the size of postnatal TRIM72-Tg hearts. TRIM72 expression was upregulated by hypertrophic inducers in cardiomyocytes, while IRS-1 was downregulated by IGF-1. TRIM72 specifically regulated IGF-1-dependent AKT-mTOR signaling, resulting in a reduction of the size of cardiomyocytes. Postnatal TRIM72-Tg hearts were smaller than control-treated hearts with inhibition of AKT-mTOR signaling. However, adult TRIM72-Tg hearts were larger than of control despite the suppression of AKT-mTOR signaling. Activation of ERK, PKC-α, and JNK were observed to be elevated in adult TRIM72-Tg, and these signals were mediated by ET-1 via the ET receptors A and B. Altogether, these results suggest that AKT signaling regulates cardiac hypertrophy in physiological conditions, and ERK signaling compensates for the absence of AKT signaling during TRIM72 overexpression, leading to pathological hypertrophy. -- Highlights: • TRIM72 inhibits AKT signaling through ubiquitination of IRS-1 in cardiac cells. • TRIM72 regulates the size of cardiac cells. • TRIM72 regulates size of postnatal TRIM72-overexpressing transgenic mice hearts. • Adult TRIM72-overexpressing transgenic mice hearts showed cardiac dysfunction. • Adult TRIM72 transgenic mice hearts showed higher expression of endothelin receptors.

Compensation of the AKT signaling by ERK signaling in transgenic mice hearts overexpressing TRIM72

International Nuclear Information System (INIS)

Ham, Young-Mi; Mahoney, Sarah Jane

2013-01-01

The AKT and ERK signaling pathways are known to be involved in cell hypertrophy, proliferation, survival and differentiation. Although there is evidence for crosstalk between these two signaling pathways in cellulo, there is less evidence for cross talk in vivo. Here, we show that crosstalk between AKT and ERK signaling in the hearts of TRIM72-overexpressing transgenic mice (TRIM72-Tg) with alpha-MHC promoter regulates and maintains their heart size. TRIM72, a heart- and skeletal muscle-specific protein, downregulates AKT-mTOR signaling via IRS-1 degradation and reduces the size of rat cardiomyocytes and the size of postnatal TRIM72-Tg hearts. TRIM72 expression was upregulated by hypertrophic inducers in cardiomyocytes, while IRS-1 was downregulated by IGF-1. TRIM72 specifically regulated IGF-1-dependent AKT-mTOR signaling, resulting in a reduction of the size of cardiomyocytes. Postnatal TRIM72-Tg hearts were smaller than control-treated hearts with inhibition of AKT-mTOR signaling. However, adult TRIM72-Tg hearts were larger than of control despite the suppression of AKT-mTOR signaling. Activation of ERK, PKC-α, and JNK were observed to be elevated in adult TRIM72-Tg, and these signals were mediated by ET-1 via the ET receptors A and B. Altogether, these results suggest that AKT signaling regulates cardiac hypertrophy in physiological conditions, and ERK signaling compensates for the absence of AKT signaling during TRIM72 overexpression, leading to pathological hypertrophy. -- Highlights: • TRIM72 inhibits AKT signaling through ubiquitination of IRS-1 in cardiac cells. • TRIM72 regulates the size of cardiac cells. • TRIM72 regulates size of postnatal TRIM72-overexpressing transgenic mice hearts. • Adult TRIM72-overexpressing transgenic mice hearts showed cardiac dysfunction. • Adult TRIM72 transgenic mice hearts showed higher expression of endothelin receptors

41 CFR 105-72.506 - Procurement records.

Science.gov (United States)

2010-07-01

... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS 72.50-Post-Award Requirements/Procurement Standards...) Justification for lack of competition when competitive bids or offers are not obtained, and (c) Basis for award cost or price. ...

19 CFR 123.72 - Written agreement requirement.

Science.gov (United States)

2010-04-01

... THE TREASURY CUSTOMS RELATIONS WITH CANADA AND MEXICO Land Border Carrier Initiative Program § 123.72... lading of illegal drugs while the conveyance is en route to the United States; (c) To conduct, to the...

Meeting Disorders.

Science.gov (United States)

Yager, Joel; Katzman, Jeffrey W

2017-12-01

Although meetings are central to organizational work, considerable time devoted to meetings in Academic Health Centers appears to be unproductively spent. The primary purposes of this article are to delineate and describe Meeting Disorders, pathological processes resulting in these inefficient and ineffective scenarios, and Meeting Fatigue Disorder (MFD), a clinical syndrome. The paper also offers preliminary approaches to remedies. The authors integrate observations made during tens of thousands of hours in administrative meetings in academic medical settings with information in the literature regarding the nature, causes and potential interventions for dysfunctional groups and meetings. Meeting Disorders, resulting from distinct pathologies of leadership and organization, constitute prevalent subgroups of the bureaucrapathologies, pathological conditions caused by dysfunctional bureaucratic processes that generate excesses of wasted time, effort, and other resources. These disorders also generate frustration and demoralization among participants, contributing to professional burnout. Meeting Fatigue Disorder (MFD) is a subjective condition that develops in individuals who overdose on these experiences and may reflect one manifestation of burnout. Meeting disorders and Meeting Fatigue Disorder occur commonly in bureaucratic life. Resources and potential remedies are available to help ameliorate their more deleterious effects.

29 CFR 2701.2 - Open meetings policy; closure of meetings.

Science.gov (United States)

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Open meetings policy; closure of meetings. 2701.2 Section... GOVERNMENT IN THE SUNSHINE ACT REGULATIONS § 2701.2 Open meetings policy; closure of meetings. (a) Policy. Commission meetings will generally be open to public observation, including meetings concerning the...

5 CFR 532.315 - Additional survey jobs.

Science.gov (United States)

2010-01-01

...: Specialized industry Specialized survey jobs Grade Aircraft Electronics Mechanic WG-11 Aircraft Structures... WG-9 Artillery and combat vehicles Automotive Mechanic (limited to data obtained in special... Electronics Electronics Mechanic WG-11 Industrial Electronic Controls Repairer WG-10 Electronic Test Equipment...

19 CFR 24.72 - Claims; set-off.

Science.gov (United States)

2010-04-01

... CUSTOMS FINANCIAL AND ACCOUNTING PROCEDURE § 24.72 Claims; set-off. When an importer of record or other... indebted to the United States, either as principal or surety, for an amount which is legally fixed and...

Wingless, decapentaplegic and EGF receptor signaling pathways interact to specify dorso-ventral pattern in the adult abdomen of Drosophila.

Science.gov (United States)

Kopp, A; Blackman, R K; Duncan, I

1999-08-01

Adult abdominal segments of Drosophila are subdivided along the dorso-ventral axis into a dorsal tergite, a ventral sternite and ventro-lateral pleural cuticle. We report that this pattern is largely specified during the pupal stage by Wingless (Wg), Decapentaplegic (Dpp) and Drosophila EGF Receptor (DER) signaling. Expression of wg and dpp is activated at the posterior edge of the anterior compartment by Hedgehog signaling. Within this region, wg and dpp are expressed in domains that are mutually exclusive along the dorso-ventral axis: wg is expressed in the sternite and medio-lateral tergite, whereas dpp expression is confined to the pleura and the dorsal midline. Neither gene is expressed in the lateral tergite. Shirras and Couso (1996, Dev. Biol. 175, 24-36) have shown that tergite and sternite cell fates are specified by Wg signaling. We find that DER acts synergistically with Wg to promote tergite and sternite identities, and that Wg and DER activities are opposed by Dpp signaling, which promotes pleural identity. Wg and Dpp interact antagonistically at two levels. First, their expression is confined to complementary domains by mutual transcriptional repression. Second, Wg and Dpp compete directly with one another by exerting opposite effects on cell fate. DER signaling does not affect the expression of wg or dpp, indicating that it interacts with Wg and Dpp at the level of cell fate determination. Within the tergite, the requirements for Wg and DER function are roughly complementary: Wg is required mainly in the medial region, whereas DER is most important laterally. Finally, we show that Dpp signaling at the dorsal midline controls dorso-ventral patterning within the tergite by promoting pigmentation in the medial region.

The history of energy industry law in Germany. With particular emphasis on the development of the Energy Act (EnWG) and current proposals for reform under discussion; Zur Entwicklung des Energierechts in Deutschland. Unter besonderer Beruecksichtigung des Energiewirtschaftsgesetzes und der aktuellen Reformdiskussion

Energy Technology Data Exchange (ETDEWEB)

Smeddinck, U.

1995-11-01

The paper describes the history and development of the regulatory framework governing the energy industry and the reasons why this legislation has been creating an organisational framework of the power industry in Germany with some strikingly peculiar features. The core structure and the essential aspects of the Energy Act (EnWG) are discussed in detail, followed by a survey of relevant cartel laws and the regime of franchise agreements and franchise duties. The amendments made in response to the oil crisis in the early seventies are mentioned, and current trends and proposals for reform are outlined. The Annex contains material illustrating a number of significant developments and issues in the history of the energy industry law, with brief explanations. The bibliography also lists publications of interest to readers wishing to get more insight into ongoing debates about problems posed by energy industry law, and proposed reforms. [Deutsch] Der Beitrag zeichnet die Entstehung und Veraenderung des rechtlichen Ordnungsrahmens nach, der fuer die derzeitige eigentuemliche Organisation der deutschen Elektrizitaetswirtschaft verantwortlich ist. Im Mittelpunkt steht das EnWG mit seinem Grundmuster. Darueberhinaus werden die einschlaegigen kartellrechtlichen Vorschriften und das Konzessionsabgabenrecht vorgestellt. Weiter wird die Reaktion des Gesetzgebers auf die dramatische Oelkrise zu Beginn der siebziger Jahre deutlich. Schliesslich wird der gegenwaertige Stand der Novellierungsbemuehungen skizziert. Die im Anhang enthaltenen Materialien veranschaulichen einige markante Punkte der energierechtlichen Entwicklung. Sie sind jeweils mit einer kurzen Erlaeuterung versehen. Das Literaturverzeichnis enthaelt auch Veroeffentlichungen zur aktuellen Diskussion, die dem interessierten Leser den vertieften Einstieg in dieses Problemfeld moeglich machen.

Radiation therapy induces circulating serum Hsp72 in patients with prostate cancer

International Nuclear Information System (INIS)

Hurwitz, Mark D.; Kaur, Punit; Nagaraja, Ganachari M.; Bausero, Maria A.; Manola, Judith; Asea, Alexzander

2010-01-01

Background and purpose: Hsp72 found in the extracellular milieu has been shown to play an important role in immune regulation. The impact of common cancer therapies on extracellular release of Hsp72 however, has been to date undefined. Materials and methods: Serum from 13 patients undergoing radiation therapy (XRT) for prostate cancer with or without hormonal therapy (ADT) was measured for levels of circulating serum Hsp72 and pro-inflammatory cytokines (IL-6 and TNF-α) using the classical sandwich ELISA technique and the relative expression of CD8 + T lymphocytes and natural killer (NK) cells was measured using flow cytometry. Mouse orthotopic xenograft of human prostate cancer tumors (DU-145 and PC-3) were used to validate and further characterize the response noted in the clinical setting. The biological significance of tumor released Hsp72 was studied in human dendritic cells (DC) in vitro. Results: Circulating serum Hsp72 levels increased an average of 3.5-fold (median per patient 4.8-fold) with XRT but not with ADT (p = 0.0002). Increases in IL-6 (3.3-fold), TNF-α (1.8-fold), CD8 + CTL (2.1-fold) and NK cells (3.2-fold) also occurred. Using PC-3 and DU-145 human prostate cancer xenograft models in mice, we confirmed that XRT induces Hsp72 release primarily from implanted tumors. In vitro studies using supernatant recovered from irradiated human prostate cancer cells point to exosomes containing Hsp72 as a possible stimulator of pro-inflammatory cytokine production and costimulatory molecules expression in human DC. Conclusions: The current study confirms for the first time in an actual clinical setting elevation of circulating serum Hsp72 with XRT. The accompanying studies in mice and in vitro identify the released exosomes containing Hsp72 as playing a pivotal role in stimulating pro-inflammatory immune responses. These findings, if validated, may lead to new treatment paradigms for common human malignancies.

Modelling Condensation and Simulation for Wheat Germ Drying in Fluidized Bed Dryer

Directory of Open Access Journals (Sweden)

Der-Sheng Chan

2018-06-01

Full Text Available A low-temperature drying with fluidized bed dryer (FBD for wheat germ (WG stabilization could prevent the loss of nutrients during processing. However, both evaporation and condensation behaviors occurred in sequence during FBD drying of WG. The objective of this study was to develop a theoretical thin-layer model coupling with the macro-heat transfer model and the bubble model for simulating both the dehydration and condensation behaviors of WG during low-temperature drying in the FBD. The experimental data were also collected for the model modification. Changes in the moisture content of WG, the air temperature of FBD chamber, and the temperature of WG during drying with different heating approaches were significantly different. The thermal input of WG drying with short heating time approach was one-third of that of WG drying with a traditional heating approach. The mathematical model developed in this study could predict the changes of the moisture content of WG and provide a good understanding of the condensation phenomena of WG during FBD drying.

Chloramine-T induced binding of monoclonal antibody B72. 3 to concanavalin-A

Energy Technology Data Exchange (ETDEWEB)

Cole, W.C.; Jhingran, S.G. (Methodist Hospital, Houston, TX (United States) Baylor Coll. of Medicine, Houston, TX (United States))

1993-07-01

The effects of chloramine-T (CT) on monoclonal antibody B72.3 were studied with particular reference to Con-A lectin binding. After exposure to chloramine-T concentrations from 0.8 to 4.0 mg/mL (115-574 mol CT/mol B72.3), B72.3 showed progressive binding to agarose-linked Con-A. This behavior was paralleled by decreasing immunoreactivity and increasing fragmentation and aggregation of B72.3 demonstrated by SDS-PAGE and size exclusion HPLC. (Author).

75 FR 73083 - Sunshine Act Meeting; Open Commission Meeting

Science.gov (United States)

2010-11-29

... FEDERAL COMMUNICATIONS COMMISSION Sunshine Act Meeting; Open Commission Meeting November 30, 2010. The Federal Communications Commission will hold an Open Meeting on the subjects listed below on... demonstrate accessibility technologies. The meeting site is fully accessible to people using wheelchairs or...

41 CFR 105-72.501 - Recipient responsibilities.

Science.gov (United States)

2010-07-01

... to such Federal, State or local authority as may have proper jurisdiction. ... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS 72.50-Post-Award Requirements/Procurement Standards... responsible authority, without recourse to the Federal awarding agency, regarding the settlement and...

20 CFR 404.384 - Reductions, suspensions, and nonpayments of special age 72 payments.

Science.gov (United States)

2010-04-01

... 72 payments when you are not residing in the United States. No special payment is due you for any... special age 72 payments. 404.384 Section 404.384 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... Survivors' Insurance Benefits; Period of Disability Special Payments at Age 72 § 404.384 Reductions...

Weight status, gender, and race/ethnicity: are there differences in meeting recommended health behavior guidelines for adolescents?

Science.gov (United States)

Minges, Karl E; Chao, Ariana; Nam, Soohyun; Grey, Margaret; Whittemore, Robin

2015-04-01

Healthy behaviors including limited screen time (ST), high physical activity (PA), and adequate fruits and vegetables consumption (FV) are recommended for adolescents, but it is unclear how gender, race/ethnicity, and weight status relate to these public health guidelines in diverse urban adolescents. Participants (N = 384) were recruited from three public high schools in or near New Haven, Connecticut. Descriptive statistics and logistic regression analyses were conducted. Most adolescents exceeded recommended levels of ST (70.5%) and did not meet guidelines for PA (87.2%) and FV (72.6%). Only 3.5% of the sample met all three guidelines. Boys were more likely to meet guidelines for PA (p differences in meeting ST, PA, or FV guidelines by weight status for the overall sample or when stratified by gender or race/ethnicity. We found alarmingly low levels of healthy behaviors in normal weight and overweight/obese adolescents. © The Author(s) 2014.

UPLC-QTOF/MS metabolic profiling unveils urinary changes in humans after a whole grain rye versus refined wheat bread intervention

DEFF Research Database (Denmark)

Bondia-Pons, Isabel; Barri, Thaer; Hanhineva, Kati

2013-01-01

Non-targeted urine metabolite profiling has not been previously exploited in the field of whole grain (WG) products. WG products, particularly rye, are important elements in a healthy Nordic diet. The aim of this study was to identify novel urinary biomarkers of WG rye bread (RB) intake in a rand......Non-targeted urine metabolite profiling has not been previously exploited in the field of whole grain (WG) products. WG products, particularly rye, are important elements in a healthy Nordic diet. The aim of this study was to identify novel urinary biomarkers of WG rye bread (RB) intake...

The effect of biological and chemical control agents on the health status of the very early potato cultivar Rosara

Directory of Open Access Journals (Sweden)

Cwalina-Ambroziak Bożena

2015-12-01

Full Text Available The external appearance and quality of table potatoes are determined, among other factors, by the health status of the plants during the growing season. Chemical control methods are often combined with biocontrol agents to effectively fight potato pathogens. Potatoes of the very early cultivar Rosara were grown in experimental plots. The plots were located in Tomaszkowo (NE Poland, 2007-2009. The experiment involved the following treatments: 1 biological control − mycorrhizal Glomus spp. inoculum was applied to the roots, − tubers were dressed and plants were sprayed with Polyversum three times during the growing season, 2 chemical control - at two-week intervals, plants were sprayed with the following fungicides: Infinito 687.5 SC and Tanos 50 WG, Valbon 72 WG and Tanos 50 WG. In the control treatment, potato plants were not protected against pathogens. During the growing season, the severity of late blight and early blight was evaluated on a nine-point scale. The composition of fungal communities colonising potato stems was analysed. The fungistatic properties of the fungicides used in the field experiment were evaluated in an in vitro test. The symptoms of infections caused by Phytophthora infestans and Alternaria spp. were significantly reduced in the treatment which used the integrated chemical and biological control. The least diverse fungal community was isolated from fungicide-treated plants. In the in vitro test, fungicides at all analysed concentrations inhibited the linear mycelial growth of selected pathogens.

Preproghrelin Leu72Met polymorphism in patients with type 2 diabetes mellitus.

Science.gov (United States)

Ukkola, O; Kesäniemi, Y A

2003-10-01

The association between the Leu72Met polymorphism of the preproghrelin gene and diabetic complications was examined in patients with type 2 diabetes mellitus. A total of 258 patients with type 2 diabetes mellitus and 522 control subjects were screened. Genotypes were determined by polymerase chain reaction technique. The diagnosis of coronary heart disease was based on clinical and ECG criteria. Laboratory analyses were carried out in the hospital laboratory. No differences in the genotype distributions and allele frequencies of the preproghrelin Leu72Met polymorphism were found between type 2 diabetes mellitus patients and controls. The polymorphism was not associated with macro- or micro-angiopathy or hypertension. However, Leu72Met polymorphism was associated with serum creatinine (P = 0.006) and lipoprotein(a) [Lp(a)] levels (P = 0.006) with Leu72Leu subjects showing the highest values. This association was observed only amongst diabetic group. The Leu72Met polymorphism of the preproghrelin gene was not related to cardiovascular disease in type 2 diabetes mellitus patients. Leu72Met polymorphism was, however, associated with serum creatinine and Lp(a) levels in diabetic patients. The mechanism might be associated with a possible change in ghrelin product and its somatotropic effect.

Mass measurement on the rp-process waiting point {sup 72}Kr

Energy Technology Data Exchange (ETDEWEB)

Rodriguez, D. [Gesellschaft fuer Schwerionenforschung mbH, Darmstadt (Germany); Kolhinen, V.S. [Jyvaeskylae Univ. (Finland); Audi, G. [CSNSM-IN2P3-Centre National de la Recherche Scientifique (CNRS), 91 - Orsay (FR)] [and others

2004-06-01

The mass of one of the three major waiting points in the astrophysical rp-process {sup 72}Kr was measured for the first time with the Penning trap mass spectrometer ISOLTRAP. The measurement yielded a relative mass uncertainty of {delta}m/m=1.2 x 10{sup -7} ({delta}m=8 keV). Other Kr isotopes, also needed for astrophysical calculations, were measured with more than one order of magnitude improved accuracy. We use the ISOLTRAP masses of{sup 72-74}Kr to reanalyze the role of the {sup 72}Kr waiting point in the rp-process during X-ray bursts. (orig.)

Preproghrelin Leu72Met polymorphism in Chinese subjects with coronary artery disease and controls.

Science.gov (United States)

Tang, Na-Ping; Wang, Lian-Sheng; Yang, Li; Gu, Hai-Juan; Zhu, Huai-Jun; Zhou, Bo; Sun, Qing-Min; Cong, Ri-Hong; Wang, Bin

2008-01-01

Ghrelin, a novel endogenous ligand for the growth hormone secretagogue receptor, is considered to exert a protective effect against atherosclerosis. The Leu72Met (+408C>A) polymorphic variant of the preproghrelin, the gene for the ghrelin precursor, has been linked to obesity, diabetes and metabolic syndrome. However, it is unclear whether this polymorphism is associated with coronary artery disease (CAD). We conducted a case-control study with 317 CAD patients and 323 controls to investigate the potential association of the Leu72Met polymorphism with the occurrence of CAD and CAD-related phenotypes in Chinese population. No significant difference in the Leu72Met genotype frequency was observed between CAD patients and controls (P=NS). The Leu72Met polymorphism was not associated with hypertension, diabetes, dyslipidemia, the number of diseased vessels, plasma total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol or fasting glucose levels in CAD patients. However, among CAD patients, those with variant genotypes (Leu72Met and Met72Met) had lower BMI (24.4+/-0.3 kg/m(2)) than Leu72Leu carriers (25.4+/-0.2 kg/m(2), adjusted P=0.033). Our data indicate that the preproghrelin Leu72Met polymorphism is not associated with CAD in Chinese population. However, the Leu72Met variant is associated with BMI among CAD patients.

Structural and functional brain signatures of C9orf72 in motor neuron disease.

Science.gov (United States)

Agosta, Federica; Ferraro, Pilar M; Riva, Nilo; Spinelli, Edoardo Gioele; Domi, Teuta; Carrera, Paola; Copetti, Massimiliano; Falzone, Yuri; Ferrari, Maurizio; Lunetta, Christian; Comi, Giancarlo; Falini, Andrea; Quattrini, Angelo; Filippi, Massimo

2017-09-01

This study investigated structural and functional magnetic resonance imaging abnormalities in hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9orf72) motor neuron disease (MND) relative to disease severity-matched sporadic MND cases. We enrolled 19 C9orf72 and 67 disease severity-matched sporadic MND patients, and 22 controls. Sporadic cases were grouped in patients with: no cognitive/behavioral deficits (sporadic-motor); same patterns of cognitive/behavioral impairment as C9orf72 cases (sporadic-cognitive); shorter disease duration versus other sporadic groups (sporadic-early). C9orf72 patients showed cerebellar and thalamic atrophy versus all sporadic cases. All MND patients showed motor, frontal, and temporoparietal cortical thinning and motor and extramotor white matter damage versus controls, independent of genotype and presence of cognitive impairment. Compared with sporadic-early, C9orf72 patients revealed an occipital cortical thinning. C9orf72 patients had enhanced visual network functional connectivity versus sporadic-motor and sporadic-early cases. Structural cerebellar and thalamic damage and posterior cortical alterations are the brain magnetic resonance imaging signatures of C9orf72 MND. Frontotemporal cortical and widespread white matter involvement are likely to be an effect of the disease evolution rather than a C9orf72 marker. Copyright © 2017 Elsevier Inc. All rights reserved.

Angiogenesis and Tissue Engineering Research

Science.gov (United States)

2010-08-01

Model with the Angiogenesis Inhibitor Sunitinib. American Pediatric Surgical Association – 40th Annual Meeting, Fajardo, Puerto Rico, May 2009...Res 149(1):115-9. 14 5. Ray NF, Denton WG, Thamer M, Henderson SC, Perry S (1998) Abdominal adhesiolysis: inpatient care and expenditures in the...nude mice (n¼ 9). Mice were injected with near- infrared agents and imaged using intravital fluorescence microscope at 0, 7, and 35 days to validate in

41 CFR 105-72.300 - Purpose of financial and program management.

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Purpose of financial and.../Financial and Program Management § 105-72.300 Purpose of financial and program management. Sections 105-72... Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General...

76 FR 70709 - Sunshine Act Meeting; Emergency Meeting Notice

Science.gov (United States)

2011-11-15

... COMMODITY FUTURES TRADING COMMISSION Sunshine Act Meeting; Emergency Meeting Notice This notice that an emergency meeting was held is published pursuant to the provisions of the Government in the Sunshine Act, Public Law 94-409, 5 U.S.C. 552b. AGENCY HOLDING THE MEETING: Commodity Futures Trading...

Dissemination of imipenem-resistant Acinetobacter baumannii with new plasmid-borne bla(OXA-72) in Taiwan.

Science.gov (United States)

Kuo, Shu-Chen; Yang, Su-Pen; Lee, Yi-Tzu; Chuang, Han-Chuan; Chen, Chien-Pei; Chang, Chi-Ling; Chen, Te-Li; Lu, Po-Liang; Hsueh, Po-Ren; Fung, Chang-Phone

2013-07-13

The systemic surveillance of imipenem-resistant Acinetobacter baumannii (IRAB) from multicenters in Taiwan revealed the emergence of isolates with bla(OXA-72). This study described their genetic makeup, mechanism of spread, and contribution to carbapenem resistance. Two hundred and ninety-one non-repetitive isolates of A. baumannii were collected from 10 teaching hospitals from different geographical regions in Taiwan from June 2007 to September 2007. Minimal inhibitory concentrations (MICs) were determined by agar dilution. Clonality was determined by pulsed-field gel electrophoresis. Plasmid was extracted and digested by restriction enzymes, and subsequently analyzed by electrophoresis and Southern blot for bla(OXA-72). The flanking regions of bla(OXA-72) were determined by inverse PCR. The contribution of bla(OXA-72) to imipenem MIC was determined by transforming plasmids carrying bla(OXA-72) into imipenem-susceptible A. baumannii. Among 142 IRAB in Taiwan, 27 harbored bla(OXA-72); 22 originated from Southern Taiwan, 5 from Central Taiwan, and none from Northern Taiwan. There were two major clones. The bla(OXA-72) was identified in the plasmids of all isolates. Two genetic structures flanking plasmid-borne bla(OXA-72) were identified and shared identical sequences in certain regions; the one described in previous literature was present in only one isolate, and the new one was present in the remaining isolates. Introduction of bla(OXA-72) resulted in an increase of imipenem MIC in the transformants. The overexpression of bla(OXA-72) mRNA in response to imipenem further supported the contribution of bla(OXA-72). In conclusion, isolates with new plasmid-borne blaOXA-72 were found to be disseminated successfully in Southern Taiwan. The spread of the resistance gene depended on clonal spread and dissemination of a new plasmid. Bla(OXA-72) in these isolates directly led to their imipenem-resistance.

SPRINT-INTERVAL TRAINING INDUCES HEAT SHOCK PROTEIN 72 IN RAT SKELETAL MUSCLES

Directory of Open Access Journals (Sweden)

Yuji Ogura

2006-06-01

Full Text Available Previous studies have demonstrated that endurance exercise training increases the level of heat shock proteins (HSPs in skeletal muscles. However, little attention has been drawn to the effects of high intensity-short duration exercise, or sprint- interval training (SIT on HSP72 level in rat skeletal muscles. This study performed to test the hypothesis that the SIT would induce the HSP72 in fast and slow skeletal muscles of rats. Young male Wistar rats (8 weeks old were randomly assigned to a control (CON or a SIT group (n = 8/group. Animals in the SIT group were trained (1 min/sprint, 6~10 sets/day and 5~6 days/week on a treadmill for 9 weeks. After the training period, HSP72 levels in the plantaris (fast and soleus (slow muscles were analyzed by Western blotting method. Enzyme activities (hexokinase, phosphofructokinase and citrate synthase and histochemical properties (muscle fiber type compositions and cross sectional area in both muscles were also determined. The SIT resulted in significantly (p < 0.05 higher levels of HSP72 in both the plantaris and soleus muscles compared to the CON group, with the plantaris producing a greater HSP72 increase than the soleus (plantaris; 550 ± 116%, soleus; 26 ± 8%, p < 0.05. Further, there were bioenergetic improvements, fast-to-slow shift of muscle fiber composition and hypertrophy in the type IIA fiber only in the plantaris muscle. These findings indicate that the SIT program increases HSP72 level of the rat hindlimb muscles, and the SIT-induced accumulation of HSP72 differs between fast and slow muscles

27 CFR 41.72b - Notice for roll-your-own tobacco.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Notice for roll-your-own tobacco. 41.72b Section 41.72b Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO IMPORTATION OF TOBACCO PRODUCTS, CIGARETTE PAPERS...

The Neuronal Ischemic Tolerance Is Conditioned by the Tp53 Arg72Pro Polymorphism.

Science.gov (United States)

Ramos-Araque, Maria E; Rodriguez, Cristina; Vecino, Rebeca; Cortijo Garcia, Elisa; de Lera Alfonso, Mercedes; Sanchez Barba, Mercedes; Colàs-Campàs, Laura; Purroy, Francisco; Arenillas, Juan F; Almeida, Angeles; Delgado-Esteban, Maria

2018-04-23

Cerebral preconditioning (PC) confers endogenous brain protection after stroke. Ischemic stroke patients with a prior transient ischemic attack (TIA) may potentially be in a preconditioned state. Although PC has been associated with the activation of pro-survival signals, the mechanism by which preconditioning confers neuroprotection is not yet fully clarified. Recently, we have described that PC-mediated neuroprotection against ischemic insult is promoted by p53 destabilization, which is mediated by its main regulator MDM2. Moreover, we have previously described that the human Tp53 Arg72Pro single nucleotide polymorphism (SNP) controls susceptibility to ischemia-induced neuronal apoptosis and governs the functional outcome of patients after stroke. Here, we studied the contribution of the human Tp53 Arg72Pro SNP on PC-induced neuroprotection after ischemia. Our results showed that cortical neurons expressing the Pro72-p53 variant exhibited higher PC-mediated neuroprotection as compared with Arg72-p53 neurons. PC prevented ischemia-induced nuclear and cytosolic p53 stabilization in Pro72-p53 neurons. However, PC failed to prevent mitochondrial p53 stabilization, which occurs in Arg72-p53 neurons after ischemia. Furthermore, PC promoted neuroprotection against ischemia by controlling the p53/active caspase-3 pathway in Pro72-p53, but not in Arg72-p53 neurons. Finally, we found that good prognosis associated to TIA within 1 month prior to ischemic stroke was restricted to patients harboring the Pro72 allele. Our findings demonstrate that the Tp53 Arg72Pro SNP controls PC-promoted neuroprotection against a subsequent ischemic insult by modulating mitochondrial p53 stabilization and then modulates TIA-induced ischemic tolerance.

Whole Grains Contribute Only a Small Proportion of Dietary Fiber to the U.S. Diet

Directory of Open Access Journals (Sweden)

Sibylle Kranz

2017-02-01

Full Text Available Dietary fiber (DF, found in whole fruits, vegetables, and whole grains (WG, is considered a nutrient of concern in the US diet and increased consumption is recommended. The present study was designed to highlight this critical importance of the difference between WG, high-fiber WG, and sources of fiber that are not from WG. The study is based on the two-day diets reported consumed by the nationally representative sample of Americans participating in What We Eat In America, the dietary component of the National Health and Nutrition Examination Survey from 2003–2010. Foods consumed were classified into tertiles of DF and WG and the contribution of fiber by differing levels of WG content were examined. Foods containing high amounts of WG and DF only contributed about 7% of total fiber intake. Overall, grain-based foods contributed 54.5% of all DF consumed. Approximately 39% of DF came from grain foods that contained no WG, rather these foods contained refined grains, which contain only small amounts of DF but are consumed in large quantities. All WG-containing foods combined contributed a total of 15.3% of DF in the American diet. Thus, public health messaging needs to be changed to specifically encourage consumption of WG foods with high levels of DF to address both recommendations.

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport.

Science.gov (United States)

Zhang, Ke; Donnelly, Christopher J; Haeusler, Aaron R; Grima, Jonathan C; Machamer, James B; Steinwald, Peter; Daley, Elizabeth L; Miller, Sean J; Cunningham, Kathleen M; Vidensky, Svetlana; Gupta, Saksham; Thomas, Michael A; Hong, Ingie; Chiu, Shu-Ling; Huganir, Richard L; Ostrow, Lyle W; Matunis, Michael J; Wang, Jiou; Sattler, Rita; Lloyd, Thomas E; Rothstein, Jeffrey D

2015-09-03

The hexanucleotide repeat expansion (HRE) GGGGCC (G4C2) in C9orf72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Recent studies support an HRE RNA gain-of-function mechanism of neurotoxicity, and we previously identified protein interactors for the G4C2 RNA including RanGAP1. A candidate-based genetic screen in Drosophila expressing 30 G4C2 repeats identified RanGAP (Drosophila orthologue of human RanGAP1), a key regulator of nucleocytoplasmic transport, as a potent suppressor of neurodegeneration. Enhancing nuclear import or suppressing nuclear export of proteins also suppresses neurodegeneration. RanGAP physically interacts with HRE RNA and is mislocalized in HRE-expressing flies, neurons from C9orf72 ALS patient-derived induced pluripotent stem cells (iPSC-derived neurons), and in C9orf72 ALS patient brain tissue. Nuclear import is impaired as a result of HRE expression in the fly model and in C9orf72 iPSC-derived neurons, and these deficits are rescued by small molecules and antisense oligonucleotides targeting the HRE G-quadruplexes. Nucleocytoplasmic transport defects may be a fundamental pathway for ALS and FTD that is amenable to pharmacotherapeutic intervention.

Citation Characteristics of Physiology Literature, 1970-72

Science.gov (United States)

Hafner, A. W.

1976-01-01

To identify and describe selected characteristics of the research literature of the basic medical science area of physiology during the three-year period 1970-72, this literature was analyzed to determine where, when, by what subject area, and in what countries it was published. (Author/PF)

26 CFR 1.72-11 - Amounts not received as annuity payments.

Science.gov (United States)

2010-04-01

... contract and which were excludable from the gross income of the recipient under the law applicable at the... purpose of determining the includibility of such payments in gross income and the general principles of... under a contract to which section 72 applies if either: (i) Paragraph (b) of § 1.72-2 is inapplicable to...

41 CFR 105-72.502 - Codes of conduct.

Science.gov (United States)

2010-07-01

... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS 72.50-Post-Award Requirements/Procurement Standards... interest is not substantial or the gift is an unsolicited item of nominal value. The standards of conduct...

The model of a bilaterally open electricity market and its compatibility with the standards set by legal regulations (EnWG and GWB). Die Vereinbarkeit des Modells eines zweiseitig offenen Strommarktes mit den Normen von EnWG und GWB

Energy Technology Data Exchange (ETDEWEB)

Toennies, J G

1993-01-01

The author arrives at the following conclusion: By considering the 'peak load princing' principle of national economy and by applying it with the aid of microelectronics, it will be possible to meet the requirements of deregulation on the one hand and recommunalisation on the other hand while keeping within the limits set by the valid requlations of communal law and energy supply law. A deregulated structure of the power supply sector will meet the demands of the market economy, while the communities, who are primarily responsible for electricity distribution, will be given scope for enforcing a structure of the power industry that takes account of the requirements of environmental protection. (orig./HSCH)

Immunolocalization of 7-2-ribonucleoprotein in the granular component of the nucleolus

International Nuclear Information System (INIS)

Reimer, G.; Raska, I.; Scheer, U.; Tan, E.M.

1988-01-01

Certain autoimmune sera contain antibodies against a nucleolar ribonucleotprotein particle associated with 7-2-RNA. In this study, the authors showed by immunofluorescence microscopy that antibodies reactive with 7-2-ribonucleoprotein immunolocalized in the granular regions of actinomycin D and 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole (DRB)--segregated nucleoli from Vero cells. By electron microscopic immunocytochemistry, antigen-antibody complexes were located in the granular component of transcriptionally active nucleoli from rat liver hepatocytes and HeLa cells. Anti-7-2-RNP antibodies from two autoimmune sera immunoprecipitated a major protein of M r 40,000 from [ 35 S] methionine-labeled HeLa cell extract. The immunolocalization data suggest that 7-2-ribonucleoprotein may be involved in stages of ribosome biogenesis which take place in the granular component of the nucleolus, i.e., assembly, maturation, and/or transport of preribosomes

36 CFR 72.56 - Grant program compliance requirements.

Science.gov (United States)

2010-07-01

... INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Grant Selection, Approval and Administration § 72...-234) Historical and Archeological Data Preservation Act of 1974 (Pub. L. 93-291) 36 CFR 66 National...

Improved penetration of wild ginseng extracts into the skin using low-temperature atmospheric pressure plasma

Science.gov (United States)

Nam, Seoul Hee; Hae Choi, Jeong; Song, Yeon Suk; Lee, Hae-June; Hong, Jin-Woo; Kim, Gyoo Cheon

2018-04-01

Wild ginseng (WG) is a well-known traditional medicinal plant that grows in natural environments in deep mountains. WG has been thought to exert potent physiological and medicinal effects, and, recently, its use in skin care has attracted much interest. This study investigated the efficient penetration of WG extracts into the skin by means of low-temperature atmospheric pressure plasma (LTAPP), and its effects on the skin at the cellular and tissue levels. NIH3T3 mouse embryonic fibroblasts and HRM-2 hairless mice were used to confirm the improved absorption of WG extracts into the skin using LTAPP. The gene expression levels in NIH3T3 cells and morphological changes in skin tissues after WG treatment were monitored using both in vitro and in vivo experiments. Although WG extracts did not show any significant effects on proliferative activity and cytotoxicity, at a concentration of 1:800, it significantly increased the expression of fibronectin and vascular endothelial growth factor. In the in vivo study, the combinational treatment of LTAPP and WG markedly induced the expression of fibronectin and integrin α6, and it thickened. Our results showed that LTAPP treatment safely and effectively accelerated the penetration of the WG extracts into the skin, thereby increasing the effects of WG on the skin.

Remedial action programs annual meeting: Meeting notes

International Nuclear Information System (INIS)

1987-01-01

The US Department of Energy Grand Junction Projects Office was pleased to host the 1987 Remedial Action programs Annual Meeting and herein presents notes from that meeting as prepared (on relatively short notice) by participants. These notes are a summary of the information derived from the workshops, case studies, and ad hoc committee reports rather than formal proceedings. The order of the materials in this report follows the actual sequence of presentations during the annual meeting

30 CFR 7.2 - Definitions.

Science.gov (United States)

2010-07-01

... has the authority to bind the company. Critical characteristic. A feature of a product that, if not... performance requirements for a product, as specified in a subpart of this part. Test procedures. The methods specified in a subpart of this part used to determine whether a product meet the performance portion of the...

40 CFR 72.2 - Definitions.

Science.gov (United States)

2010-07-01

... Power Production Facility (IPP) means a source that: (1) Is nonrecourse project financed, as defined by... material; or (8) A research gas mixture. Capacity factor means either: (1) The ratio of a unit's actual... electric power planning methodology meeting the requirements of § 73.82(a)(4) of this chapter. Life-of-the...

Carrier of Wingless (Cow), a Secreted Heparan Sulfate Proteoglycan, Promotes Extracellular Transport of Wingless

Science.gov (United States)

Chang, Yung-Heng; Sun, Yi Henry

2014-01-01

Morphogens are signaling molecules that regulate growth and patterning during development by forming a gradient and activating different target genes at different concentrations. The extracellular distribution of morphogens is tightly regulated, with the Drosophila morphogen Wingless (Wg) relying on Dally-like (Dlp) and transcytosis for its distribution. However, in the absence of Dlp or endocytic activity, Wg can still move across cells along the apical (Ap) surface. We identified a novel secreted heparan sulfate proteoglycan (HSPG) that binds to Wg and promotes its extracellular distribution by increasing Wg mobility, which was thus named Carrier of Wg (Cow). Cow promotes the Ap transport of Wg, independent of Dlp and endocytosis, and this function addresses a previous gap in the understanding of Wg movement. This is the first example of a diffusible HSPG acting as a carrier to promote the extracellular movement of a morphogen. PMID:25360738

Growth of wild muskoxen under two nutritional regimes in Greenland

Directory of Open Access Journals (Sweden)

Carsten Riis Olesen

1994-12-01

Full Text Available Growth of muskoxen in Jameson Land, East Greenland (EG and in Angujaartorfiup Nunaa, West Greenland (WG is affected by the different nutritional conditions in the two areas. The abundance and availability of forage plants is highest in WG. Muskoxen in WG reach sexual maturity one year earlier than muskoxen in EG. A significant proportion of female muskoxen in WG conceive at the age of 16 months and give birth to their first calf as two years olds. The horn bases of the muskox bulls in WG are fully developed during their third year of life, but their maximum body weight (BW is attained at the age of six. Average BW of adult bulls (4 yr+ in WG is 306 kg which is 23 % greater than in adult bulls in EG. BW is seasonally more variable in EG than in WG owing to greater seasonal fluctuation in food supply.

Increased whole grain consumption does not affect blood biochemistry, body composition, or gut microbiology in healthy, low-habitual whole grain consumers.

Science.gov (United States)

Ampatzoglou, Antonios; Atwal, Kiranjit K; Maidens, Catherine M; Williams, Charlotte L; Ross, Alastair B; Thielecke, Frank; Jonnalagadda, Satya S; Kennedy, Orla B; Yaqoob, Parveen

2015-02-01

Whole-grain (WG) foods have been suggested to reduce the risk of cardiovascular disease, but studies are inconsistent and effects on cardiovascular risk markers are not clear. The objective of this study was to assess the impact of increasing WG consumption to at least 80 g/d on overall dietary intake, body composition, blood pressure (BP), blood lipids, blood glucose, gastrointestinal microbiology, and gastrointestinal symptoms in healthy, middle-aged adults with habitual WG intake food frequency questionnaires and subsequently completed 3-day food diaries (3DFDs) to confirm habitual WG consumption. Subjects consumed diets high in WG (>80 g/d) or low in WG [range of cereal food products. The 3DFDs, diet compliance diaries, and plasma alkylresorcinols were used to verify compliance. During the WG intervention, consumption increased from 28 g/d to 168 g/d (P increase in plasma alkylresorcinols (P increased 24-h fecal weight (P = 0.08) and reduction in body weight (P = 0.10) and BMI (P = 0.08) during the WG intervention compared with the RG period. A combination of dietary advice and provision of commercially available food items enabled subjects with a low-moderate habitual consumption of WG to substantially increase their WG intake, but there was little effect on blood biochemical markers, body composition, BP, fecal measurements, or gut microbiology. This trial was registered at www.controlled-trials.com as ISRCTN36521837. © 2015 American Society for Nutrition.

Produção do Superprecoce a Partir de Bezerros Desmamados aos 72 ou 210 Dias de Idade Feedlot Performance of Young Males Weaned at 72 or 210 Days

Directory of Open Access Journals (Sweden)

João Restle

2002-07-01

Full Text Available O experimento foi conduzido com o objetivo de avaliar o desempenho em confinamento, dos 210 aos 408 dias de idade, de bezerros previamente desmamados aos 72 (T72 ou 210 (T210 dias. Foram utilizados 36 machos não castrados da raça Braford (5/8 Hereford 3/8 Nelore. O peso médio no início do experimento foi de 209 kg (T72 e 192 kg (T210. O confinamento compreendeu 30 dias de adaptação dos animais e 168 dias de avaliação, sendo dividido em quatro períodos de 42 dias. A relação volumoso:concentrado foi de 60:40 para o 1º e 2º períodos, 50:50 para o 3º período e 45:55 para o 4º período. Não houve interação entre idade de desmame e período de avaliação em confinamento para os parâmetros relativos aos consumos médios por animal de matéria seca (CMS e de energia digestível (CED, expressos em kg/dia e Mcal/dia (CMSD e CEDD, por 100 kg de peso vivo (CMSP e CEDP e por unidade de tamanho metabólico (CMSM e CEDM, ao ganho de peso médio diário (GMD, à conversão alimentar (CA e eficiência energética (EE. Animais desmamados aos 210 dias apresentaram maiores CMSP (2,25 contra 2,07% PV e CEDP (7,05 contra 6,48% PV em relação aos animais desmamados ao 72 dias de idade. Não houve diferença no CMSD (6,75 contra 6,98 kg/dia, no GMD (1,066 contra 1,074 kg/dia, na eficiência de conversão da matéria seca (6,42 contra 6,72 kg de MS/kg ganho de PV e da energia digestível consumida (20,18 contra 21,13 Mcal/kg ganho de PV em ganho de peso vivo para os animais desmamados aos 72 ou 210 dias de idade, respectivamente. Os pesos de abate e de carcaça quente foram similares entre as duas idades, sendo, respectivamente, de 424 e 232 kg para os animais do T72 e de 406 e 221 kg para dos T210. Os resultados mostram que animais desmamados aos 72 dias de idade apresentaram desempenho durante a terminação, pesos de abate e de carcaça similares aos desmamados aos 210 dias.The experiment was conducted to evaluate the feedlot performance, from

Using Controversial Issues to Help Middle School Students Become Informed and Active Citizens: A Randomized Evaluation of the Word Generation Program

OpenAIRE

Lin, Alex Romeo

2014-01-01

Although American schools are required to meet civic education goals of preparing students to become active and informed citizens, high quality civic opportunities (e.g. service learning and volunteering) are consistently less available to youth of color who are typically enrolled in schools located in high poverty communities. The purpose of this study is to evaluate the efficacy of the Word Generation (WG) to improve students' self-reported civic engagement (N = 5,798) in the context of a r...

10 CFR 50.72 - Immediate notification requirements for operating nuclear power reactors.

Science.gov (United States)

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Immediate notification requirements for operating nuclear power reactors. 50.72 Section 50.72 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF... systems. (8) Emergency ac electrical power systems, including: Emergency diesel generators (EDGs...

76 FR 59454 - Sunshine Act Meeting; Notice of Public Meeting

Science.gov (United States)

2011-09-26

... RAILROAD RETIREMENT BOARD Sunshine Act Meeting; Notice of Public Meeting Notice is hereby given that the Railroad Retirement Board will hold a meeting on October 6, 2011, 10 a.m. at the Board's meeting room on the 8th floor of its headquarters building, 844 North Rush Street, Chicago, Illinois...

41 CFR 105-72.602 - Financial reporting.

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Financial reporting. 105... § 105-72.602 Financial reporting. (a) The following forms or such other forms as may be approved by OMB are authorized for obtaining financial information from recipients. (1) SF-269 or SF-269A, Financial...

Ethiopian Journal of Environmental Studies & Management 7(2 ...

African Journals Online (AJOL)

Osondu

2013-03-27

Mar 27, 2013 ... Ethiopian Journal of Environmental Studies & Management 7(2): 108 – 116, 2014. ISSN:1998- ... cement factory on a sample of 126 tenements from 11 residential settlements within Ewekoro local .... health risk but aesthetics.

Development of oligoclonal nanobodies for targeting the tumor-associated glycoprotein 72 antigen

DEFF Research Database (Denmark)

Sharifzadeh, Zahra; Rahbarizadeh, Fatemeh; Shokrgozar, Mohammad Ali

2013-01-01

The tumor-associated glycoprotein 72 (TAG-72) is a membrane mucin whose over-expression is correlated with advanced tumor stage and increased invasion and metastasis. In this study, we identified a panel of four nanobodies, single variable domains of dromedary heavy-chain antibodies that specific...

19 CFR 7.2 - Insular possessions of the United States other than Puerto Rico.

Science.gov (United States)

2010-04-01

... than Puerto Rico. 7.2 Section 7.2 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF... NAVAL STATION § 7.2 Insular possessions of the United States other than Puerto Rico. (a) Insular possessions of the United States other than Puerto Rico are also American territory but, because those insular...

48 CFR 915.404-4-72 - Special considerations for cost-plus-award-fee contracts.

Science.gov (United States)

2010-10-01

... cost-plus-award-fee contracts. 915.404-4-72 Section 915.404-4-72 Federal Acquisition Regulations System....404-4-72 Special considerations for cost-plus-award-fee contracts. (a) When a contract is to be awarded on a cost-plus-award-fee basis several special considerations are appropriate. Fee objectives for...

STS-72 Flight Day 7

Science.gov (United States)

1996-01-01

On this seventh day of the STS-72 mission, the flight crew, Cmdr. Brian Duffy, Pilot Brent W. Jett, and Mission Specialists Leroy Chiao, Daniel T. Barry, Winston E. Scott, and Koichi Wakata (NASDA), awakened to music from the Walt Disney movie, 'Snow White and the Seven Dwarfs.' Chiao and Scott performed the second spacewalk of the mission where they tested equipment and work platforms that will be used in building the planned International Space Station. This spacewalk was almost seven hours long. Wakata conducted an interview with and answered questions from six graders from a Japanese school in Houston, Texas.

Ethiopian Journal of Environmental Studies & Management 7(2 ...

African Journals Online (AJOL)

Osondu

2013-11-01

Nov 1, 2013 ... Ethiopian Journal of Environmental Studies & Management 7(2): 153 – 159, 2014. ISSN:1998-0507 ... and food processing industries, battery, cement, milling and ..... risks, but can provide basic information on source of water ...

50 CFR 20.72 - Violation of State law.

Science.gov (United States)

2010-10-01

... export any migratory bird, or any part, nest, or egg of any such bird, in violation of any applicable law... WILDLIFE AND PLANTS (CONTINUED) MIGRATORY BIRD HUNTING Federal, State, and Foreign Law § 20.72 Violation of...

75 FR 59292 - Meeting of the Advisory Committee; Meeting

Science.gov (United States)

2010-09-27

... inclusion on future Joint Board examinations in actuarial mathematics, pension law and methodology referred... closed meeting of the Advisory Committee on Actuarial Examinations. DATES: The meeting will be held on... INFORMATION: Notice is hereby given that the Advisory Committee on Actuarial Examinations will meet at...

50 CFR 25.72 - Reporting of accidents.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Reporting of accidents. 25.72 Section 25... Reporting of accidents. Accidents involving damage to property, injury to the public or injury to wildlife..., but in no event later than 24 hours after the accident, by the persons involved, to the refuge manager...

Vision and eye health in children 36 to <72 months: proposed data definitions.

Science.gov (United States)

Marsh-Tootle, Wendy L; Russ, Shirley A; Repka, Michael X

2015-01-01

To recommend a standardized approach for measuring progress toward national goals to improve preschool children's eye health. A multidisciplinary panel of experts reviewed existing measures and national vision-related goals during a series of face-to-face meetings and conference calls. The panel used a consensus process, informed by existing data related to delivery of eye and non-eye services to preschool children. Currently, providers of vision screening and eye examinations lack a system to provide national- or state-level estimates of the proportion of children who receive either a vision screening or an eye examination. The panel developed numerator and denominator definitions to measure rates of children "who completed a vision screening in a medical or community setting using a recommended method, or received an eye examination by an optometrist or ophthalmologist at least once between the ages of 36 to <72 months." A separate measure for children with neurodevelopmental disorders and measures for eye examination and follow-up were also developed. The panel recommended that these measures be implemented at national, state, and local levels. Standardized performance measures that include all eye services received by a child are needed at state and national levels to measure progress toward improving preschool children's eye health.

Event reporting guidelines 10 CFR 50.72 and 50.73. Revision 1

Energy Technology Data Exchange (ETDEWEB)

Allison, D P; Harper, M R; Jones, W R; MacKinnon, J B; Sandin, S S

1998-01-01

Revision 1 to NUREG-1022 clarifies the immediate notification requirements of Title 10 of the Code of Federal Regulations, Part 50, Section 50.72 (10 CFR 50.72), and the 30-day written licensee event report (LER) requirements of 10 CFR 50.73 for nuclear power plants. This revision was initiated to improve the reporting guidelines related to 10 CFR 50.72 and 50.73 and to consolidate these guidelines into a single reference document. A first draft of this document was noticed for public comment in the Federal Register on october 7, 1991 (56 FR 50598). A second draft was noticed for comment in the Federal Register on February 7, 1994 (59 FR 5614). This document updates and supersedes NUREG-1022 and its Supplements 1 and 2 (published in September 1983, February 1984, and September 1985, respectively). It does not change the reporting requirements of 10 CFR 50.72 and 50.73.

Event reporting guidelines 10 CFR 50.72 and 50.73. Revision 1

International Nuclear Information System (INIS)

Allison, D.P.; Harper, M.R.; Jones, W.R.; MacKinnon, J.B.; Sandin, S.S.

1998-01-01

Revision 1 to NUREG-1022 clarifies the immediate notification requirements of Title 10 of the Code of Federal Regulations, Part 50, Section 50.72 (10 CFR 50.72), and the 30-day written licensee event report (LER) requirements of 10 CFR 50.73 for nuclear power plants. This revision was initiated to improve the reporting guidelines related to 10 CFR 50.72 and 50.73 and to consolidate these guidelines into a single reference document. A first draft of this document was noticed for public comment in the Federal Register on october 7, 1991 (56 FR 50598). A second draft was noticed for comment in the Federal Register on February 7, 1994 (59 FR 5614). This document updates and supersedes NUREG-1022 and its Supplements 1 and 2 (published in September 1983, February 1984, and September 1985, respectively). It does not change the reporting requirements of 10 CFR 50.72 and 50.73

42 CFR 7.2 - Establishment of a user charge.

Science.gov (United States)

2010-10-01

... DISTRIBUTION OF REFERENCE BIOLOGICAL STANDARDS AND BIOLOGICAL PREPARATIONS § 7.2 Establishment of a user charge... producing and distributing reference biological standards and biological preparations. ...

46 CFR 72.15-20 - Ventilation for crew quarters and passenger spaces.

Science.gov (United States)

2010-10-01

... shown that a natural system will provide adequate ventilation. However, vessels which trade regularly in... 46 Shipping 3 2010-10-01 2010-10-01 false Ventilation for crew quarters and passenger spaces. 72... VESSELS CONSTRUCTION AND ARRANGEMENT Ventilation § 72.15-20 Ventilation for crew quarters and passenger...

29 CFR 801.72 - Responsibility of the Office of Administrative Law Judges.

Science.gov (United States)

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Responsibility of the Office of Administrative Law Judges. 801.72 Section 801.72 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative...

76 FR 17967 - Meeting of the Advisory Committee; Meeting

Science.gov (United States)

2011-03-31

... Joint Board examinations in actuarial mathematics, pension law and methodology referred to in 29 U.S.C... closed meeting of the Advisory Committee on Actuarial Examinations. DATES: The meeting will be held on... INFORMATION: Notice is hereby given that the Advisory Committee on Actuarial Examinations will meet at Mercer...

77 FR 19034 - Meeting of the Advisory Committee; Meeting

Science.gov (United States)

2012-03-29

... Joint Board examinations in actuarial mathematics, pension law and methodology referred to in 29 U.S.C... closed meeting of the Advisory Committee on Actuarial Examinations. DATES: The meeting will be held on... INFORMATION: Notice is hereby given that the Advisory Committee on Actuarial Examinations will meet at...

40 CFR 72.30 - Requirement to apply.

Science.gov (United States)

2010-07-01

... two or more affected units are located at a source, the permitting authority may, in its sole... permitting authority on or before January 1, 1996. (ii) For any source with a new unit under § 72.6(a)(3)(i... to the permitting authority at least 24 months before the later of January 1, 2000 or the date on...

Ethylene response factor AtERF72 negatively regulates Arabidopsis thaliana response to iron deficiency.

Science.gov (United States)

Liu, Wei; Li, Qiwei; Wang, Yi; Wu, Ting; Yang, Yafei; Zhang, Xinzhong; Han, Zhenhai; Xu, Xuefeng

2017-09-23

Ethylene regulates the plant's response to stress caused by iron (Fe) deficiency. However, specific roles of ERF proteins in response to Fe deficiency remain poorly understood. Here, we investigated the role of ERF72 in response to iron deficiency in Arabidopsis thaliana. In this study, the levels of the ethylene response factor AtERF72 increased in leaves and roots induced under the iron deficient conditions. erf72 mutant plants showed increased growth compared to wild type (WT) when grown in iron deficient medium for 5 d. erf72 mutants had increased root H + velocity and the ferric reductase activity, and increase in the expression of the iron deficiency response genes iron-regulated transporter 1 (IRT1) and H + -ATPase (HA2) levels in iron deficient conditions. Compared to WT plants, erf72 mutants retained healthy chloroplast structure with significantly higher Fe and Mg content, and decreased chlorophyll degradation gene pheophorbide a oxygenase (PAO) and chlorophyllase (CLH1) expression when grown in iron deficient media. Yeast one-hybrid analysis showed that ERF72 could directly bind to the promoter regions of iron deficiency responses genes IRT1, HA2 and CLH1. Based on our results, we suggest that ethylene released from plants under iron deficiency stress can activate the expression of ERF72, which responds to iron deficiency in the negative regulation. Copyright © 2017 Elsevier Inc. All rights reserved.

TP53 codon 72 polymorphism in pigmentary phenotypes

Indian Academy of Sciences (India)

2012-01-20

Jan 20, 2012 ... pigmentation by acting as a transcription factor for other genes that are ... skin phototype I-II, burns after exposure to UVR and the development of .... morphisms of TP53 codon 72 with breast carcinoma risk: evidence from ...

77 FR 59979 - Meeting of the Advisory Committee; Meeting

Science.gov (United States)

2012-10-01

... actuarial mathematics, pension law and methodology referred to in 29 U.S.C. 1242(a)(1)(B). A determination... closed meeting of the Advisory Committee on Actuarial Examinations. DATES: The meeting will be held on... is hereby given that the Advisory Committee on Actuarial Examinations will meet at Towers Watson, 800...

Standard format and content guide for financial assurance mechanisms required for decommissioning under 10 CFR parts 30, 40, 70, and 72

International Nuclear Information System (INIS)

1989-08-01

The Standard Format and Content Guide for Financial Assurance Mechanisms Required for Decommissioning under 10 CFR Parts 30, 40, 70, and 72, discusses the information to be provided in a license application and established a uniform format for presenting the information required to meet the decommissioning licensing requirements. The use of the Standard Format and Content Guide will (1) help ensure that the license application contains the information required by the regulations, (2) aid the applicant in ensuring that the information is complete, (3) help persons reading the Standard Format and Content Guide to locate information, and (4) contribute to shortening the time required for the review process. The Standard Format and Content Guide ensures that the information required to perform the review is provided, and in a useable format

Planning and conducting meetings effectively, part I: planning a meeting.

Science.gov (United States)

Harolds, Jay

2011-12-01

Meetings are held by leaders for many purposes, including conveying information, raising morale, asking for opinions, brain storming, making people part of the problem-solving process, building trust, getting to a consensus, and making decisions. However, many meetings waste time, some undermine the leader's power, and some decrease morale. Part I of this series of articles gives some tips on basic planning for decision-making meetings. Part II of this series of articles analyzes selected components of decision-making meetings. Part III of this series will be on how the chairperson keeps decision-making meetings on track to make them efficient and productive.

Online and Off-line Visualization of Meeting Information and Meeting Support

NARCIS (Netherlands)

Nijholt, Antinus; Rienks, R.J.; Zwiers, Jakob; Reidsma, Dennis

2006-01-01

In current meeting research we see modest attempts to visualize the information that has been obtained by either capturing and probably more importantly by interpreting the activities that take place during a meeting. The meetings being considered take place in smart meeting rooms. Cameras,

Online and Off-line Visualization of Meeting Information and Meeting Support

NARCIS (Netherlands)

Nijholt, Antinus; Seah, H.S.; Rienks, R.J.; Zwiers, Jakob; Reidsma, Dennis

2006-01-01

In current meeting research we see modest attempts to visualize the information that has been obtained by either capturing and, probably more importantly, by interpreting the activities that take place during a meeting. The meetings being considered take place in smart meeting rooms. Cameras,

MODARIA WG5: Towards a practical guidance for including uncertainties in the results of dose assessment of routine releases

Energy Technology Data Exchange (ETDEWEB)

Mora, Juan C. [Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas - CIEMAT (Spain); Telleria, Diego [International Atomic Energy Agency - IAEA (Austria); Al Neaimi, Ahmed [Emirates Nuclear Energy Corporation - ENEC (United Arab Emirates); Blixt Buhr, Anna Ma [Vattenfall AB (Sweden); Bonchuk, Iurii [Radiation Protection Institute - RPI (Ukraine); Chouhan, Sohan [Atomic Energy of Canada Limited - AECL (Canada); Chyly, Pavol [SE-VYZ (Slovakia); Curti, Adriana R. [Autoridad Regulatoria Nuclear - ARN (Argentina); Da Costa, Dejanira [Instituto de Radioprotecao e Dosimetria - IRD (Brazil); Duran, Juraj [VUJE Inc (Slovakia); Galeriu, Dan [Horia Hulubei National Institute of Physics and Nuclear Engineering - IFIN-HH (Romania); Haegg, Ann- Christin; Lager, Charlotte [Swedish Radiation Safety Authority - SSM (Sweden); Heling, Rudie [Nuclear Research and Consultancy Group - NRG (Netherlands); Ivanis, Goran; Shen, Jige [Ecometrix Incorporated (Canada); Iosjpe, Mikhail [Norwegian Radiation Protection Authority - NRPA (Norway); Krajewski, Pawel M. [Central Laboratory for Radiological Protection - CLOR (Poland); Marang, Laura; Vermorel, Fabien [Electricite de France - EdF (France); Mourlon, Christophe [Institut de Radioprotection et de Surete Nucleaire - IRSN (France); Perez, Fabricio F. [Belgian Nuclear Research Centre - SCK (Belgium); Woodruffe, Andrew [Federal Authority for Nuclear Regulation - FANR (United Arab Emirates); Zorko, Benjamin [Jozef Stefan Institute (Slovenia)

2014-07-01

MODARIA (Modelling and Data for Radiological Impact Assessments) project was launched in 2012 with the aim of improving the capabilities in radiation dose assessment by means of acquisition of improved data for model testing, model testing and comparison, reaching consensus on modelling philosophies, approaches and parameter values, development of improved methods and exchange of information. The project focuses on areas where uncertainties remain in the predictive capability of environmental models, emphasizing in reducing associated uncertainties or developing new approaches to strengthen the evaluation of the radiological impact. Within MODARIA, four main areas were defined, one of them devoted to Uncertainty and Variability. In this area four working groups were included, Working Group 5 dealing with the 'uncertainty and variability analysis for assessments of radiological impacts arising from routine discharges of radionuclides'. Whether doses are estimated by using measurement data, by applying models, or through a combination of measurements and calculations, the variability and uncertainty contribute to a distribution of possible values. The degree of variability and uncertainty is represented by the shape and extent of that distribution. The main objective of WG5 is to explore how to consider uncertainties and variabilities in the results of assessment of doses in planned situations for controlling the impact of routine releases from radioactive and nuclear installations to the environment. The final aim is to produce guidance for the calculation of uncertainties in these exposure situations and for the presentation of such results to the different stakeholders. To achieve that objective the main tasks identified were: to find tools and methods for uncertainty and variability analysis applicable to dose assessments in routine radioactive discharges, to define scenarios where information on uncertainty and variability of parameters is available

Report on the 2nd Florence International Symposium on Advances in Cardiomyopathies: 9th meeting of the European Myocardial and Pericardial Diseases WG of the ESC

Directory of Open Access Journals (Sweden)

Franco Cecchi

2012-12-01

Full Text Available A bridge between clinical and basic science aiming at cross fertilization, with leading experts presenting alongside junior investigators, is the key feature of the “2nd Florence International Symposium on Advances in Cardiomyopathies” , 9th Meeting of the Myocardial and Pericardial Diseases Working Group of the European Society of Cardiology, which was held in Florence, Italy on 26-­-28th September 2012. Patients with cardiomyopathies, with an estimated 3 per thousand prevalence in the general population, constitute an increasingly large proportion of patients seen by most cardiologists. This class of diseases, which are mostly genetically determined with different transmission modalities, can cause important and often unsolved management problems, despite rapid advances in the field. On the other hand, few other areas of cardiology have seen such an impressive contribution from basic science and translational research to the understanding of their pathophysiology and clinical management. The course was designed to constantly promote close interaction between basic science and clinical practice and highlight the top scientific and translational discoveries in this field in 10 scientific sessions. It was preceded by two mini-­-courses, which included the basic concepts of cardiomyocyte mechanical and electrophysiological properties and mechanisms, how-­-to sessions for clinical diagnosis and management and illustrative case study presentations of different cardiomyopathies.

28 CFR 16.72 - Exemption of Office of the Associate Attorney General System-limited access.

Science.gov (United States)

2010-07-01

... Attorney General System-limited access. 16.72 Section 16.72 Judicial Administration DEPARTMENT OF JUSTICE....72 Exemption of Office of the Associate Attorney General System—limited access. (a) The following...) General Files System of the Office of the Associate Attorney General (JUSTICE/AAG-001). These exemptions...

Hsp72 preserves muscle function and slows progression of severe muscular dystrophy.

Science.gov (United States)

Gehrig, Stefan M; van der Poel, Chris; Sayer, Timothy A; Schertzer, Jonathan D; Henstridge, Darren C; Church, Jarrod E; Lamon, Severine; Russell, Aaron P; Davies, Kay E; Febbraio, Mark A; Lynch, Gordon S

2012-04-04

Duchenne muscular dystrophy (DMD) is a severe and progressive muscle wasting disorder caused by mutations in the dystrophin gene that result in the absence of the membrane-stabilizing protein dystrophin. Dystrophin-deficient muscle fibres are fragile and susceptible to an influx of Ca(2+), which activates inflammatory and muscle degenerative pathways. At present there is no cure for DMD, and existing therapies are ineffective. Here we show that increasing the expression of intramuscular heat shock protein 72 (Hsp72) preserves muscle strength and ameliorates the dystrophic pathology in two mouse models of muscular dystrophy. Treatment with BGP-15 (a pharmacological inducer of Hsp72 currently in clinical trials for diabetes) improved muscle architecture, strength and contractile function in severely affected diaphragm muscles in mdx dystrophic mice. In dko mice, a phenocopy of DMD that results in severe spinal curvature (kyphosis), muscle weakness and premature death, BGP-15 decreased kyphosis, improved the dystrophic pathophysiology in limb and diaphragm muscles and extended lifespan. We found that the sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase (SERCA, the main protein responsible for the removal of intracellular Ca(2+)) is dysfunctional in severely affected muscles of mdx and dko mice, and that Hsp72 interacts with SERCA to preserve its function under conditions of stress, ultimately contributing to the decreased muscle degeneration seen with Hsp72 upregulation. Treatment with BGP-15 similarly increased SERCA activity in dystrophic skeletal muscles. Our results provide evidence that increasing the expression of Hsp72 in muscle (through the administration of BGP-15) has significant therapeutic potential for DMD and related conditions, either as a self-contained therapy or as an adjuvant with other potential treatments, including gene, cell and pharmacological therapies.

25 CFR 273.72 - Appeal from decision to cancel contract for cause.

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Appeal from decision to cancel contract for cause. 273.72 Section 273.72 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND... decision to cancel contract for cause. A contractor may appeal the decision of a Bureau official to cancel...

Mechanism study of multimode ultrasound pretreatment on the enzymolysis of wheat gluten.

Science.gov (United States)

Zhang, Yanyan; Li, Jing; Li, Suyun; Ma, Haile; Zhang, Hua

2018-03-01

Ultrasound pretreatment could improve the angiotensin-I converting enzyme (ACE) inhibitory activity of hydrolysates of wheat gluten (WG). The working mode of ultrasound has an important effect on the enzymatic hydrolysis of protein. The results showed that the optimum working mode of ultrasound was alternate dual-frequency mode (20/35 kHz), substrate concentration was 30 g L -1 , initial temperature of the suspension was 30 °C, ultrasound pretreatment time was 10 min and power density was 150 W L -1 . Under optimised conditions, ACE inhibitory activity of WG hydrolysates reached to its maximum value in advance. The surface hydrophobicity (H 0 ) of WG and the content of small peptides at the beginning of the enzymolysis were improved by the ultrasound pretreatment. The structure of WG was destroyed by the ultrasound pretreatment. The enzymatic residue of ultrasound pretreated WG were damaged greater than control. It was concluded that alternate dual-frequency ultrasound pretreatment improved the ACE inhibitory activity. Ultrasonic pretreatment may loosen the tissue of WG aggregate, and help the enzyme alcalase to attack the interior of WG aggregate easily, which resulted in the release of low molecular weight peptides from WG aggregate. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

Solution-Processed Wide-Bandgap Organic Semiconductor Nanostructures Arrays for Nonvolatile Organic Field-Effect Transistor Memory.

Science.gov (United States)

Li, Wen; Guo, Fengning; Ling, Haifeng; Liu, Hui; Yi, Mingdong; Zhang, Peng; Wang, Wenjun; Xie, Linghai; Huang, Wei

2018-01-01

In this paper, the development of organic field-effect transistor (OFET) memory device based on isolated and ordered nanostructures (NSs) arrays of wide-bandgap (WBG) small-molecule organic semiconductor material [2-(9-(4-(octyloxy)phenyl)-9H-fluoren-2-yl)thiophene]3 (WG 3 ) is reported. The WG 3 NSs are prepared from phase separation by spin-coating blend solutions of WG 3 /trimethylolpropane (TMP), and then introduced as charge storage elements for nonvolatile OFET memory devices. Compared to the OFET memory device with smooth WG 3 film, the device based on WG 3 NSs arrays exhibits significant improvements in memory performance including larger memory window (≈45 V), faster switching speed (≈1 s), stable retention capability (>10 4 s), and reliable switching properties. A quantitative study of the WG 3 NSs morphology reveals that enhanced memory performance is attributed to the improved charge trapping/charge-exciton annihilation efficiency induced by increased contact area between the WG 3 NSs and pentacene layer. This versatile solution-processing approach to preparing WG 3 NSs arrays as charge trapping sites allows for fabrication of high-performance nonvolatile OFET memory devices, which could be applicable to a wide range of WBG organic semiconductor materials. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Whole-grain products and whole grain types are associated with lower all-cause and cause-specific mortality in the Scandinavian HELGA cohort

DEFF Research Database (Denmark)

Johnsen, Nina Føns; Frederiksen, Kirsten; Christensen, Jane

2015-01-01

No study has yet investigated the intake of different types of whole grain (WG) in relation to all-cause and cause-specific mortality in a healthy population. The aim of the present study was to investigate the intake of WG products and WG types in relation to all-cause and cause-specific mortali......%CI 0·86, 0·91) for a doubling of intake). In particular, intake of breakfast cereals and non-white bread was associated with lower mortality. We also found lower all-cause mortality with total intake of different WG types (women: MRR 0·88 (95%CI 0·86, 0·92); men: MRR 0·88 (95%CI 0·86, 0...... quartile compared with the lowest for breakfast cereals, non-white bread, total WG products, oat, rye (only men), wheat and total WG types. The MRR for highest v. lowest quartile of intake of total WG products was 0·68 (95% CI 0·62, 0·75, P for trend over quartiles , 0·0001) for women and 0·75 (95%CI 0...

Broadbanding of circularly polarized patch antenna by waveguided magneto-dielectric metamaterial

Directory of Open Access Journals (Sweden)

Xin Mi Yang

2015-12-01

Full Text Available Design of bandwidth-enhanced circularly polarized (CP patch antenna using artificial magneto-dielectric substrate was investigated. The artificial magneto-dielectric material adopted here takes the form of waveguided metamaterial (WG-MTM. In particular, the embedded meander line (EML structure was employed as the building element of the WG-MTM. As verified by the retrieved effective medium parameters, the EML-based waveguided magneto-dielectric metamaterial (WG-MDM exhibits two-dimensionally isotropic magneto-dielectric property with respect to TEM wave excitations applied in two orthogonal directions. A CP patch antenna loaded with the EML-based WG-MDM (WG-MDM antenna has been proposed and its design procedure is described in detail. Simulation results show that the impedance and axial ratio bandwidths of the WG-MDM antenna have increased by 125% and 133%, respectively, compared with those obtained with pure dielectric substrate offering the same patch size. The design of the novel WG-MDM antenna was also validated by measurement results, which show good agreement with their simulated counterparts.

Analysis of the publication rate of the abstracts presented at a national gastroenterology meeting after 6 years

Science.gov (United States)

Gandhi, Divyangkumar; Mclean, Richard W.; Laiyemo, Adeyinka O.

2017-01-01

Background/Aims Abstract presentations at scientific meetings provide an opportunity to convey the results of important research. Unfortunately, many abstracts are not eventually published as full manuscripts. We evaluated factors associated with publication of abstracts as manuscripts up to 6.5 years after presentation at the 73rd scientific meeting of the American College of Gastroenterology in 2008. Methods All abstracts, excluding case reports, presented at the meeting were evaluated. We systematically searched for matching manuscripts indexed in PubMed or EMBASE up till May 2015. We used logistic regression models to determine factors associated with manuscript publication and calculated odds ratios (OR) and 95% confidence intervals (CI). Results Of included 791 abstracts, 249 (31.5%) were published as manuscripts within 6.5 years. Oral presentation (OR=2.11; 95%CI: 1.15-3.87), multicenter studies (OR=2.67; 95%CI: 1.44-4.95), abstracts by University-based authors (OR=1.80; 95%CI: 1.20-2.72), and funded research (OR=2.15; 95%CI: 1.43-3.23) were more likely to be published. Winning an award at the meeting was not associated with manuscript publication (OR=1.09; 95%CI: 0.57-2.06). Conclusions There is an urgent need to improve dissemination of scientific knowledge through publication of abstracts presented at gastroenterology meetings as manuscripts. Mentors should endeavor to encourage their mentees to complete this final stage of their scholarly activities. PMID:27931019

Probabilistic safety analysis on an SBWR 72 hours after the initiating event

International Nuclear Information System (INIS)

Dominguez Bautista, M.T.; Peinador Veira, M.

1996-01-01

Passive plants, including SBWRs, are designed to carry out safety functions with passive systems during the first 72 hours after the initiation event with no need for manual actions or external support. After this period, some recovery actions are required to enable the passive systems to continue performing their safety functions. The study was carried out by the INITEC-Empresarios Agrupados Joint Venture within the framework of the international group collaborating with GE on this project. Its purpose has been to assess, by means of probabilistic criteria, the importance to safety of each of these support actions, in order to define possible requirements to be considered in the design in respect of said recovery actions. In brief, the methodology developed for this objective consists of (1) quantifying success event trees from the PSA up to 72 hours, (2) determining the actions required in each sequence to maintain Steady State after 72 hours, (3) identifying available alternative core cooling methods in each sequence, (4) establishing the approximate (order of magnitude) realizability of each alternative method, (5) calculating the frequency of core damage as a function of the failure probability of post-72-hour actions and (6) analysing the importance of post-72-hour actions. The results of this analysis permit the establishment, right from the conceptual design phase, of the requirements that will arise to ensure these actions in the long term, enhancing their reliability and preventing the accident from continuing beyond this period. (Author)

High-spin lifetime measurements in the N=Z nucleus Kr72

Science.gov (United States)

Andreoiu, C.; Svensson, C. E.; Afanasjev, A. V.; Austin, R. A. E.; Carpenter, M. P.; Dashdorj, D.; Finlay, P.; Freeman, S. J.; Garrett, P. E.; Greene, J.; Grinyer, G. F.; Görgen, A.; Hyland, B.; Jenkins, D.; Johnston-Theasby, F.; Joshi, P.; Machiavelli, A. O.; Moore, F.; Mukherjee, G.; Phillips, A. A.; Reviol, W.; Sarantites, D. G.; Schumaker, M. A.; Seweryniak, D.; Smith, M. B.; Valiente-Dobón, J. J.; Wadsworth, R.

2007-04-01

High-spin states in the N=Z nucleus Kr72 have been populated in the Ca40(Ca40, 2α)Kr72 fusion-evaporation reaction at a beam energy of 165 MeV using the Gammasphere array for γ-ray detection coupled to the Microball array for charged particle detection. The previously observed bands in Kr72 were extended to an excitation energy of ˜24 MeV and angular momentum of 30ℏ. Using the Doppler shift attenuation method the lifetimes of high-spin states were measured for the first time. Excellent agreement between the results of calculations within the isovector mean field theory and experiment is observed both for rotational and deformation properties. No enhancement of quadrupole deformation expected in the presence of isoscalar t=0 np pairing is observed. Current data do not show any evidence for the existence of the isoscalar np pairing.

48 CFR 3052.216-72 - Performance evaluation plan.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Performance evaluation... CONTRACT CLAUSES Text of Provisions and Clauses 3052.216-72 Performance evaluation plan. As prescribed in... Evaluation Plan (DEC 2003) (a) A Performance Evaluation Plan shall be unilaterally established by the...

48 CFR 1252.216-72 - Performance evaluation plan.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Performance evaluation....216-72 Performance evaluation plan. As prescribed in (TAR) 48 CFR 1216.406(b), insert the following clause: Performance Evaluation Plan (OCT 1994) (a) A Performance Evaluation Plan shall be unilaterally...

48 CFR 852.214-72 - Alternate item(s).

Science.gov (United States)

2010-10-01

... AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 852.214-72... 2008) Bids on []* will be given equal consideration along with bids on []** and any such bids received... [].** * Contracting officer will insert an alternate item that is considered acceptable. ** Contracting officer will...

The structure of collective bands in 72Ge

International Nuclear Information System (INIS)

Tripathy, K.C.; Sahu, R.

1999-01-01

In recent years, extensive experimental studies of nuclei in the mass region A=80 have led to exciting discoveries of large ground state deformations, coexistence of shapes, band crossings, rapid variations of structure with changing nucleon numbers etc. A theoretical study of 72 Ge is presented

Exercise induces the release of heat shock protein 72 from the human brain in vivo

OpenAIRE

Lancaster, G. I.; Møller, K.; Nielsen, B.; Secher, N. H.; Febbraio, M. A.; Nybo, L.

2004-01-01

The present study tested the hypothesis that in response to physical stress the human brain has the capacity to release heat shock protein 72 (Hsp72) in vivo. Therefore, 6 humans (males) cycled for 180 minutes at 60% of their maximal oxygen uptake, and the cerebral Hsp72 response was determined on the basis of the internal jugular venous to arterial difference and global cerebral blood flow. At rest, there was a net balance of Hsp72 across the brain, but after 180 minutes of exercise, we were...

Meetings as a positive boost? How and when meeting satisfaction impacts employee empowerment

NARCIS (Netherlands)

Allen, J.A.; Lehmann-Willenbrock, N.K.; Sands, S.

2016-01-01

Meetings constitute an important context for understanding organizational behavior and employee attitudes. Employees spend ever-increasing time in meetings and often complain about their meetings. In contrast, we explore the positive side of meetings and argue that satisfying meetings can empower

Recombinant human B7.2 IgV-like domain expressed in bacteria maintains its co-stimulatory activity in vitro.

Science.gov (United States)

Yan, Xiaocai; Ma, Jun; Zheng, Jin; Lai, Baochang; Geng, Yiping; Wang, Yili; Si, Lüsheng

2002-07-01

To investigate which of the two immunoglobulin (Ig)-like domains, the immunoglobulin variable region homologous domain IgV (hB7.2 IgV) and the immunoglobulin constant region homologous domain IgC (hB7.2 IgC) on the human B7.2 molecule contains receptor binding sites, and to evaluate whether the B7.2 protein expressed in bacteria has biological activity in vitro. Three fragments of hB7.2 IgV,hB7.2 IgC and the complete extracellular region of human B7.2 containing both the IgV and IgC domains,hB7.2 Ig (V+C), were amplified by PCR and subcloned into pGEM-Teasy. Three recombinants,pGEX-4T-3-hB7.2 IgV,pGEX-4T-3-hB7.2 IgC and pGEX-4T-3-hB7.2 Ig (V+C), were generated by cloning the fragments into a prokaryote expression plasmid (pGEX-4T-3) and transformed into the host strain E. coli DH5alpha. The relevant target fusion proteins consisting of GST and hB7.2 IgV,hB7.2 IgC and hB7.2 Ig (V+C), were identified by SDS-PAGE and Western blotting. With the presence of the first signal imitated by anti-CD3 antibody, T cell activation was observed by exposing purified T lymphocytes to each soluble form of the three bacterially-produced human B7.2 fusion proteins by [(3)H]-TdR incorporation. Three recombinant fusion proteins of human B7.2, GST-hB7.2 IgV, GST-hB7.2 IgC and GST-hB7.2 Ig (V+C) were produced and detected in inclusion body form from engineered bacteria. With the first signal present,T lymphocytes proliferated when co-stimulated by bacterially-produced either GST-hB7.2 Ig (V+C) or GST-hB7.2 IgV fusion proteins, but not by GST-hB7.2 IgC. Functional human B7.2 fusion protein can be produced in bacteria. The IgV-like domain of human B7.2 is sufficient for B7.2 to interact with its counter-receptors and co-stimulate T lymphocytes.

B7-2 expressed on EL4 lymphoma suppresses antitumor immunity by an interleukin 4-dependent mechanism.

Science.gov (United States)

Stremmel, C; Greenfield, E A; Howard, E; Freeman, G J; Kuchroo, V K

1999-03-15

For T cells to become functionally activated they require at least two signals. The B7 costimulatory molecules B7-1 and B7-2 provide the "second signal" pivotal for T cell activation. In this report, we studied the relative roles of B7-1 and B7-2 molecules in the induction of antitumor immunity to the T cell thymoma, EL4. We generated EL4 tumor cells that expressed B7-1, B7-2, and B7-1+B7-2 by transfecting murine cDNAs. Our results demonstrate that EL4-B7-1 cells are completely rejected in syngeneic mice. Unlike EL4-B7-1 cells, we find that EL4-B7-2 cells are not rejected but progressively grow in the mice. A B7-1- and B7-2-EL4 double transfectant was generated by introducing B7-2 cDNA into the EL4-B7-1 tumor line that regressed in vivo. The EL4-B7-1+B7-2 double transfectant was not rejected when implanted into syngeneic mice but progressively grew to produce tumors. The double transfectant EL4 cells could costimulate T cell proliferation that could be blocked by anti-B7-1 antibodies, anti-B7-2 antibodies, or hCTLA4 immunoglobulin, showing that the B7-1 and B7-2 molecules expressed on the EL4 cells were functional. In vivo, treatment of mice implanted with double-transfected EL4 cells with anti-B7-2 monoclonal antibody resulted in tumor rejection. Furthermore, the EL4-B7-2 and EL4-B7-1+B7-2 cells, but not the wild-type EL4 cells, were rejected in interleukin 4 (IL-4) knockout mice. Our data suggests that B7-2 expressed on some T cell tumors inhibits development of antitumor immunity, and IL-4 appears to play a critical role in abrogation of the antitumor immune response.

48 CFR 3452.227-72 - Advertising of awards.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Advertising of awards... Clauses 3452.227-72 Advertising of awards. As prescribed in 3427.472, insert the following clause in all solicitations and contracts other than purchase orders: Advertising of Awards (AUG 1987) The contractor agrees...

C9orf72 hexanucleotide repeat expansions in Chinese sporadic amyotrophic lateral sclerosis.

Science.gov (United States)

He, Ji; Tang, Lu; Benyamin, Beben; Shah, Sonia; Hemani, Gib; Liu, Rong; Ye, Shan; Liu, Xiaolu; Ma, Yan; Zhang, Huagang; Cremin, Katie; Leo, Paul; Wray, Naomi R; Visscher, Peter M; Xu, Huji; Brown, Matthew A; Bartlett, Perry F; Mangelsdorf, Marie; Fan, Dongsheng

2015-09-01

A hexanucleotide repeat expansion (HRE) in the C9orf72 gene has been identified as the most common mutation in amyotrophic lateral sclerosis (ALS) among Caucasian populations. We sought to comprehensively evaluate genetic and epigenetic variants of C9orf72 and the contribution of the HRE in Chinese ALS cases. We performed fragment-length and repeat-primed polymerase chain reaction to determine GGGGCC copy number and expansion within the C9orf72 gene in 1092 sporadic ALS (sALS) and 1062 controls from China. We performed haplotype analysis of 23 single-nucleotide polymorphisms within and surrounding C9orf72. The C9orf72 HRE was found in 3 sALS patients (0.3%) but not in control subjects (p = 0.25). For 2 of the cases with the HRE, genotypes of 8 single-nucleotide polymorphisms flanking the HRE were inconsistent with the haplotype reported to be strongly associated with ALS in Caucasian populations. For these 2 individuals, we found hypermethylation of the CpG island upstream of the repeat, an observation not detected in other sALS patients (p HRE were highly associated with repeat lengths >8 repeats implying that both haplotypes may confer instability of repeat length. Copyright © 2015 Elsevier Inc. All rights reserved.

C9orf72’s interaction with Rab GTPases - modulation of membrane traffic and autophagy

Directory of Open Access Journals (Sweden)

Bor Luen Tang

2016-10-01

Full Text Available Hexanucleotide repeat expansion in an intron of Chromosome 9 open reading frame 72 (C9orf72 is the most common genetic cause of Amyotrophic Lateral Sclerosis (ALS and Frontotemporal Dementia (FTD. While functional haploinsufficiency of C9orf72 resulting from the mutation may play a role in ALS/FTD, the actual cellular role of the protein has been unclear. Recent findings have now shown that C9orf72 physically and functionally interacts with multiple members of the Rab small GTPases family, consequently exerting important influences on cellular membrane traffic and the process of autophagy. Loss of C9orf72 impairs endocytosis in neuronal cell lines, and attenuated autophagosome formation. Interestingly, C9orf72 could influence autophagy both as part of a Guanine nucleotide exchange factor (GEF complex, or as a Rab effector that facilitates transport of the Unc-51-like Autophagy Activating Kinase 1 (Ulk1 autophagy initiation complex. The cellular function of C9orf72 is discussed in the light of these recent findings

41 CFR 102-72.30 - What are the different types of delegations related to real estate leasing?

Science.gov (United States)

2010-07-01

... types of delegations related to real estate leasing? 102-72.30 Section 102-72.30 Public Contracts and... REGULATION REAL PROPERTY 72-DELEGATION OF AUTHORITY Delegation of Authority § 102-72.30 What are the different types of delegations related to real estate leasing? Delegations related to real estate leasing...

75 FR 42125 - Notice of Public Meeting, Dakotas Resource Advisory Council Meeting

Science.gov (United States)

2010-07-20

... Public Meeting, Dakotas Resource Advisory Council Meeting AGENCY: Bureau of Land Management, Interior..., Bureau of Land Management (BLM) Dakotas Resource Advisory Council (RAC) will meet as indicated below. DATES: The next regular meeting of the Dakotas Resource Advisory Council will be held on September 2...

Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber.

Science.gov (United States)

Vitaglione, Paola; Mennella, Ilario; Ferracane, Rosalia; Rivellese, Angela A; Giacco, Rosalba; Ercolini, Danilo; Gibbons, Sean M; La Storia, Antonietta; Gilbert, Jack A; Jonnalagadda, Satya; Thielecke, Frank; Gallo, Maria A; Scalfi, Luca; Fogliano, Vincenzo

2015-02-01

Epidemiology associates whole-grain (WG) consumption with several health benefits. Mounting evidence suggests that WG wheat polyphenols play a role in mechanisms underlying health benefits. The objective was to assess circulating concentration, excretion, and the physiologic role of WG wheat polyphenols in subjects with suboptimal dietary and lifestyle behaviors. A placebo-controlled, parallel-group randomized trial with 80 healthy overweight/obese subjects with low intake of fruit and vegetables and sedentary lifestyle was performed. Participants replaced precise portions of refined wheat (RW) with a fixed amount of selected WG wheat or RW products for 8 wk. At baseline and every 4 wk, blood, urine, feces, and anthropometric and body composition measures were collected. Profiles of phenolic acids in biological samples, plasma markers of metabolic disease and inflammation, and fecal microbiota composition were assessed. WG consumption for 4-8 wk determined a 4-fold increase in serum dihydroferulic acid (DHFA) and a 2-fold increase in fecal ferulic acid (FA) compared with RW consumption (no changes). Similarly, urinary FA at 8 wk doubled the baseline concentration only in WG subjects. Concomitant reduction in plasma tumor necrosis factor-α (TNF-α) after 8 wk and increased interleukin (IL)-10 only after 4 wk with WG compared with RW (P = 0.04) were observed. No significant change in plasma metabolic disease markers over the study period was observed, but a trend toward lower plasma plasminogen activator inhibitor 1 with higher excretion of FA and DHFA in the WG group was found. Fecal FA was associated with baseline low Bifidobacteriales and Bacteroidetes abundances, whereas after WG consumption, it correlated with increased Bacteroidetes and Firmicutes but reduced Clostridium. TNF-α reduction correlated with increased Bacteroides and Lactobacillus. No effect of dietary interventions on anthropometric measurements and body composition was found. WG wheat

Validation of Reported Whole-Grain Intake from a Web-Based Dietary Record against Plasma Alkylresorcinol Concentrations in 8- to 11-Year-Olds Participating in a Randomized Controlled Trial

DEFF Research Database (Denmark)

Biltoft-Jensen, Anja Pia; Damsgaard, Camilla T.; W. Andersen, Elisabeth

2016-01-01

meal × 3 mo crossover trial. Reported WG intake and plasma AR concentrations were compared when children ate their usual bread-based lunch (UBL) and when served a hot lunch meal (HLM). Correlations and cross-classification were used to rank subjects according to intake. The intraclass correlation......BACKGROUND: Whole-grain (WG) intake is important for human health, but accurate intake estimation is challenging. Use of a biomarker for WG intake provides a possible way to validate dietary assessment methods. OBJECTIVE: Our aim was to validate WG intake from 2 diets reported by children, using...... plasma alkylresorcinol (AR) concentrations, and to investigate the 3-mo reproducibility of AR concentrations and reported WG intake. METHODS: AR concentrations were analyzed in fasting blood plasma samples, and WG intake was estimated in a 7-d web-based diary by 750 participants aged 8-11 y in a 2 school...

C9orf72 expansion presenting as an eating disorder.

Science.gov (United States)

Sanders, Peter; Ewing, Isobel; Ahmad, Kate

2016-03-01

This report describes a 64-year-old woman with a strong family history of motor neuron disease, whose diagnosis of behavioural variant frontotemporal dementia was delayed due to her initial presentation with atypical manifestations, including restriction of oral intake resulting in low weight, disordered eating and anxiety. Upon investigation, she was found to be a carrier of the C9orf72 hexanucleotide repeat expansion. Our case supports previous publications asserting that C9orf72 mutation carriers manifest with diverse clinical syndromes, and expands the phenotype to include anorexia and food refusal as potential features of the condition. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.

Meetings in Academe: It's Time for an "EXTREME MEETING MAKEOVER!"

Science.gov (United States)

Berk, Ronald A.

2012-01-01

Meetings have a bad reputation with faculty. Rarely does one hear a positive word uttered about an upcoming or past meeting. That reputation has metastasized throughout higher education. The primary reason is because meetings can be major time wasters, accomplishing very little, often deteriorating into just another social event, or they may be…

76 FR 21779 - Notice of Public Meeting, Dakotas Resource Advisory Council Meeting

Science.gov (United States)

2011-04-18

... Public Meeting, Dakotas Resource Advisory Council Meeting AGENCY: Bureau of Land Management, Interior..., Bureau of Land Management (BLM) Dakotas Resource Advisory Council (RAC), will meet as indicated below. DATES: The next regular meeting of the Dakotas Resource Advisory Council will be held on May 11, 2011 in...

75 FR 15724 - Notice of Public Meeting, Dakotas Resource Advisory Council Meeting

Science.gov (United States)

2010-03-30

... Public Meeting, Dakotas Resource Advisory Council Meeting AGENCY: Bureau of Land Management, Interior..., Bureau of Land Management (BLM) Dakotas Resource Advisory Council (RAC) will meet as indicated below. DATES: The next regular meeting of the Dakotas Resource Advisory Council will be held on May 6, 2010, in...

76 FR 43705 - Notice of Public Meeting, Dakotas Resource Advisory Council Meeting

Science.gov (United States)

2011-07-21

... Public Meeting, Dakotas Resource Advisory Council Meeting AGENCY: Bureau of Land Management, Interior... Interior, Bureau of Land Management (BLM) Dakotas Resource Advisory Council (RAC), will meet as indicated below. DATES: The next regular meeting of the Dakotas Resource Advisory Council will be held on Aug. 17...

Eyelid sporotrichosis: Unique clinical findings in 72 patients.

Science.gov (United States)

Zhang, Yaqin; Wang, Yuqian; Cong, Lele; Yang, Hongfeng; Cong, Xianling

2016-02-01

Sporotrichosis on the eyelids is uncommon and has been rarely reported. As the largest series of 72 adults and children with eyelid sporotrichosis from Jilin ̀P̀̀rovince in China, this study provides useful information for the improved diagnosis and treatment of sporotrichosis. © 2015 The Australasian College of Dermatologists.

77 FR 22800 - Notice of Public Meeting, Dakotas Resource Advisory Council Meeting

Science.gov (United States)

2012-04-17

... Public Meeting, Dakotas Resource Advisory Council Meeting AGENCY: Bureau of Land Management, Interior..., Bureau of Land Management (BLM) Dakotas Resource Advisory Council (RAC) will meet as indicated below. DATES: The next regular meeting of the Dakotas RAC will be held on May 9, 2012, in Spearfish, SD. The...

Comparison of Serum CA72-4 and CEA Levels in Patient with Endoscopically Suspected Gastric Carcinoma.

Science.gov (United States)

Rehena, Z; Ghosh, C K; Afroz, F; Alam, M B; Ferdousi, S; Mahmuduzzaman, M; Sultana, T; Ahmed, A N

2015-07-01

Several serum tumour markers have been described for gastric cancer. Preoperative level of tumor marker helps to predict the diagnosis of gastric carcinoma. CA72-4 as a serum tumour marker for gastric cancer is evaluated, and compared its utility in this regard with that of carcinoembryonic antigen (CEA). Analysis of gastric carcinoma by serum levels of CEA and CA72-4 and their correlation with histopathology help the clinician to develop his management strategies for gastric carcinoma. A prospective observational study was carried out in the Department of Clinical Pathology, Bangabandhu Sheikh Mujib Medical University (BSMMU) in collaboration with Department of Surgery BSMMU, DMCH, Delta Hospital Limited, Dhaka, during the period of October 2010 to September 2011. Serum CA72-4 and CEA were analyzed in 71 endoscopically suspected patients for gastric carcinoma. Among them 58 cases were diagnosed as malignant gastric disease and 13 cases were nonmalignant gastric disease. Sensitivity of CA 72-4 and CEA were 48.3% and 31% respectively and specificity were 92.3% and 76.9% respectively. In poorly differentiated carcinoma, positivity for CA72-4 and CEA were 55.6% and 36.1% respectively. Because of the high positivity of CA72-4 in poorly differentiated carcinoma, CA72-4 is reliable tumour marker in advanced cases. As the sensitivity of CA72-4 was more than that of CEA in diagnosis of gastric cancer, CA72-4 can be used in conjunction with other diagnostic tests like endoscopy that would be more helpful for the patients.

Beam Pattern Analysis of the Plate-type Waveguide Sensor for Under-Sodium Viewing

International Nuclear Information System (INIS)

Kim, Hoewoong; Joo, Youngsang; Park, Changgyu; Kim, Jongbum

2013-01-01

Sensor for under-sodium viewing (USV) in a sodium-cooled fast reactor (SFR) has been developed. In the developed WG sensor approach, the A0 mode Lamb wave is used and a thin beryllium layer is coated on the waveguide surface to improve the ultrasonic radiation ability in a sodium environment. In this work, the beam pattern radiated from the developed plate-type WG sensor is investigated analytically to understand and predict the ultrasonic beam radiation property of the WG sensor in a liquid. Analytic calculations to obtain beam patterns for two kinds of WG sensors with and without beryllium coating layers were carried out and the results were compared with those obtained by experiments. In this work, the beam pattern of the plate-type WG sensor for USV was investigated analytically. Employing the far-field approximation, the acoustic response at a given measurement position was calculated for the plate-type WG sensors with and without beryllium coating layers. The beam patterns of WG sensors were predicted by the analytic calculation and the corresponding experiments were carried out. The results showed that the far-field beam pattern radiated from the plate-type WG sensor could be well predicted by an analytic calculation. The radiation beam angles obtained by the analytical calculation were in good agreement with those obtained by experiments

STAFF MEETING

CERN Document Server

2003-01-01

I should like to invite all members of the CERN Personnel to a meeting on Wednesday 25th June 2003 at 11.00 hrs - Auditorium, bldg. 500 to give a report on the outcome of the June Meetings of Council and its Committees. Closed-circuit transmission of the meeting will be available in the AB Auditorium (Prévessin), the AB Auditorium (Meyrin - bldg. 6), the IT Auditorium (bldg. 31) and the AT Auditorium (bldg. 30). Luciano Maiani Director General

40 CFR 432.72 - Effluent limitations attainable by the application of the best practicable control technology...

Science.gov (United States)

2010-07-01

... application of the best practicable control technology currently available (BPT). 432.72 Section 432.72... AND POULTRY PRODUCTS POINT SOURCE CATEGORY Sausage and Luncheon Meats Processors § 432.72 Effluent limitations attainable by the application of the best practicable control technology currently available (BPT...

Was passiert vor dem Meeting? Small Talk steigert die Meetingeffektivität [What happens before meetings? Small talk promotes meeting effectiveness

NARCIS (Netherlands)

Allen, J.A.; Lehmann-Willenbrock, N.K.

2013-01-01

Research interest: We explore how pre-meeting small talk impacts meeting effectiveness through the” ripple effect”, allowing before meeting communication/behaviors to ripple into and impact the scheduled meeting. Method: Data was obtained using an online survey of working adults (N = 252). A new

A Micro-scale Wind Turbine Fed BLDC Motor for Electric Vehicle Drive Application

OpenAIRE

Kazraji, Saeed Masoumi; Khanabdal, Saheb; Soflaye, Ramin Bavil; Sabahi, Mehran

2016-01-01

In this paper a permanent magnet brushless dc motor (PMBLDCM) based driver with a wind-generator (WG) in maximum power point tracking (MPPT) condition is proposed. The proposed system has a high efficiency buck-type dc/dc converter and control unit running the MPPT function. The WG optimal power characteristic and wind speed measuring data are not required while the WG works in variable speed mode, therefore higher reliability, simplicity, lower cost and less mechanical Tension of the WG are ...

Structure models of G72, the product of a susceptibility gene to schizophrenia.

Science.gov (United States)

Kato, Yusuke; Fukui, Kiyoshi

2017-02-01

The G72 gene is one of the most susceptible genes to schizophrenia and is contained exclusively in the genomes of primates. The product of the G72 gene modulates the activity of D-amino acid oxidase (DAO) and is a small protein prone to aggregate, which hampers its structural studies. In addition, lack of a known structure of a homologue makes it difficult to use the homology modelling method for the prediction of the structure. Thus, we first developed a hybrid ab initio approach for small proteins prior to the prediction of the structure of G72. The approach uses three known ab initio algorithms. To evaluate the hybrid approach, we tested our prediction of the structure of the amino acid sequences whose structures were already solved and compared the predicted structures with the experimentally solved structures. Based on these comparisons, the average accuracy of our approach was calculated to be ∼5 Å. We then applied the approach to the sequence of G72 and successfully predicted the structures of the N- and C-terminal domains (ND and CD, respectively) of G72. The predicted structures of ND and CD were similar to membrane-bound proteins and adaptor proteins, respectively. © The Authors 2016. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.

MeetingVis: Visual Narratives to Assist in Recalling Meeting Context and Content.

Science.gov (United States)

Shi, Yang; Bryan, Chris; Bhamidipati, Sridatt; Zhao, Ying; Zhang, Yaoxue; Ma, Kwan-Liu

2018-06-01

In team-based workplaces, reviewing and reflecting on the content from a previously held meeting can lead to better planning and preparation. However, ineffective meeting summaries can impair this process, especially when participants have difficulty remembering what was said and what its context was. To assist with this process, we introduce MeetingVis, a visual narrative-based approach to meeting summarization. MeetingVis is composed of two primary components: (1) a data pipeline that processes the spoken audio from a group discussion, and (2) a visual-based interface that efficiently displays the summarized content. To design MeetingVis, we create a taxonomy of relevant meeting data points, identifying salient elements to promote recall and reflection. These are mapped to an augmented storyline visualization, which combines the display of participant activities, topic evolutions, and task assignments. For evaluation, we conduct a qualitative user study with five groups. Feedback from the study indicates that MeetingVis effectively triggers the recall of subtle details from prior meetings: all study participants were able to remember new details, points, and tasks compared to an unaided, memory-only baseline. This visual-based approaches can also potentially enhance the productivity of both individuals and the whole team.

An overview of past and present CFD activities within the framework of WGAMA

International Nuclear Information System (INIS)

Smith, B.L.; Mahaffy, J.H.; Bestion, D.; Zigh, G.

2011-01-01

In 2003, three Writing Groups (WG1, WG2, WG3) were established within the Working Group on Analysis and Management of Accidents (WGAMA) of the OECD Nuclear Energy Agency. The groups had the responsibility of summarising the state-of-the-art in the application of Computational Fluid Dynamics (CFD) to items of concern in nuclear reactor safety. The Best Practice Guidelines (BPGs) drawn up by the WG1 group defined the procedures which need to be followed to produce trustworthy results from a CFD simulation. The WG2 group itemised the assessment base which underpins single-phase CFD as an established technology. The WG3 group focused on the challenges that still need to be faced before two-phase CFD may be regarded as a mature science. The background to the activity, method of approach, documented evidence, status and current activities are described under appropriate section headings in this paper. (author)

S-nitrosylation of TRIM72 at cysteine 144 is critical for protection against oxidation-induced protein degradation and cell death.

Science.gov (United States)

Kohr, Mark J; Evangelista, Alicia M; Ferlito, Marcella; Steenbergen, Charles; Murphy, Elizabeth

2014-04-01

Oxidative stress and membrane damage following myocardial ischemia/reperfusion injury are important contributors to cardiomyocyte death and the loss of myocardial function. Our previous study identified cysteine 144 (C144) of tripartite motif-containing protein 72 (TRIM72) as a potential site for S-nitrosylation (SNO). TRIM72 is a cardioprotective membrane repair protein that can be both activated and targeted for degradation by different oxidative modifications. Consistent with the potential regulation of TRIM72 by various oxidative modifications, we found that SNO levels increased at C144 of TRIM72 with ischemic preconditioning. Therefore, to investigate the role of C144 in the regulation of TRIM72 function, we mutated C144 of TRIM72 to a serine residue (TRIM72(C144S)), and expressed either TRIM72(WT) or TRIM72(C144S) in HEK-293 cells, which lack endogenous TRIM72, in order to examine the effect of this mutation on the functional stability of TRIM72 and on cell survival. We hypothesized that SNO of TRIM72 stabilizes the protein, thus allowing for membrane repair and enhanced cell survival. Upon treatment with hydrogen peroxide (H2O2), we found that TRIM72(WT) levels were decreased, but not TRIM72(C144S) and this correlated with increased H2O2-induced cell death in TRIM72(WT) cells. Additionally, we found that treatment with the cardioprotective S-nitrosylating agent S-nitrosoglutathione (GSNO), was able to preserve TRIM72(WT) protein levels and enhance TRIM72(WT)-mediated cell survival, but had no effect on TRIM72(C144S) levels. Consistent with our hypothesis, GSNO was also found to increase SNO levels and inhibit H2O2-induced irreversible oxidation for TRIM72(WT) without affecting TRIM72(C144S). In further support of our hypothesis, GSNO blocked the ischemia/reperfusion-induced decrease in TRIM72 levels and reduced infarct size in a Langendorff-perfused heart model. The results of these studies have important implications for cardioprotection and suggest that

Commuting for meetings

DEFF Research Database (Denmark)

Fosgerau, Mogens; Engelson, Leonid; Franklin, Joel P.

2014-01-01

Urban congestion causes travel times to exhibit considerable variability, which leads to coordination problems when people have to meet. We analyze a game for the timing of a meeting between two players who must each complete a trip of random duration to reach the meeting, which does not begin...

75 FR 21629 - HIT Policy Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2010-04-26

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the National Coordinator for Health Information Technology HIT Policy Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Policy Committee...

41 CFR 105-72.205 - Metric system of measurement.

Science.gov (United States)

2010-07-01

... Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services Administration 72-UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER... system of measurement. The Metric Conversion Act, as amended by the Omnibus Trade and Competitiveness Act...

Preproghrelin Leu72Met polymorphism predicts a lower rate of developing renal dysfunction in type 2 diabetic nephropathy.

Science.gov (United States)

Lee, Dae-Yeol; Kim, Sun-Young; Jo, Dae-Sun; Hwang, Pyoung Han; Kang, Kyung Pyo; Lee, Sik; Kim, Won; Park, Sung Kwang

2006-07-01

Ghrelin is a novel peptide hormone, which exerts somatotropic, orexigenic and adipogenic effects. Recent studies have shown that the preproghrelin Leu72Met polymorphism is associated with serum creatinine (Scr) concentration in type 2 diabetes; 72Met carriers exhibited lower Scr levels as compared with the 72Met non-carriers. We hypothesized that the preproghrelin Leu72Met polymorphism is associated with a lower rate of developing renal dysfunction in patients with type 2 diabetic nephropathy. The preproghrelin Leu72Met polymorphism was investigated using PCR techniques in 138 patients with diabetic nephropathy divided into two groups, one with normal renal function and the other with renal dysfunction. Determination of the frequency of the preproghrelin Leu72Met polymorphism was the main outcome measure. The frequency of the Leu72Met polymorphism in diabetic nephropathy was significantly lower in patients with renal dysfunction (15.9%, P polymorphism was also associated with serum total cholesterol levels in diabetic nephropathy patients with renal dysfunction; the 72Met carriers had lower total cholesterol levels than the 72Met non-carriers (P < 0.05). These data suggest that 72Met carrier status may be used as a marker predicting a lower chance of developing renal dysfunction in diabetic nephropathy.

75 FR 5595 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2010-02-03

... Technology HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National... Health Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT... Federal Health IT Strategic Plan, and in accordance with policies developed by the HIT Policy Committee...

75 FR 21628 - HIT Standards Committee Advisory Meeting; Notice of Meeting

Science.gov (United States)

2010-04-26

... Technology HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards... Strategic Plan, and in accordance with policies developed by the HIT Policy Committee. Date and Time: The...

27 CFR 6.72 - “Tie-in” sales.

Science.gov (United States)

2010-04-01

... OF THE TREASURY LIQUORS âTIED-HOUSEâ Unlawful Inducements Quota Sales § 6.72 “Tie-in” sales. The act by an industry member of requiring that a retailer purchase one product (as defined in § 6.11) in... and not individually. However, an industry member is not precluded from selling two or more kinds or...

Meeting Mid-Year Meeting

Indian Academy of Sciences (India)

23 Newsletter of the Indian Academy of ScienCE. 57th Annual. Meeting ... Srinivas, Institute for Social and Economic. Change ... "Quantum mechanics and statistical mechanics of anyons" .... Special Issue on Geomagnetic Methods and.

Meetings in Organizations

DEFF Research Database (Denmark)

Ravn, Ib

as having to serve organizational stakeholders (such as customers and users), and work must be subjectively meaningful to the modern, well-educated employee. Do meetings answer to these challenges? A survey of 300 knowledge workers in five highly successful, knowledge-intensive corporations in Denmark...... showed that although employees were satisfied with their managers; traditional meeting-management skills, the customer was largely invisible in organizational meetings, and the hearts and minds of the employees were not engaged to any significant degree in meetings. It is concluded that despite massive...

Taking minutes of meetings

CERN Document Server

Gutmann, Joanna

2016-01-01

aking Minutes of Meetings guides you through the entire process behind minute taking: arranging the meeting; writing the agenda; creating the optimum environment; structuring the meeting and writing notes up accurately. The minute-taker is one of the most important and powerful people in a meeting and you can use this opportunity to develop your knowledge, broaden your horizons and build credibility within the organization. Taking Minutes of Meetings is an easy to read 'dip-in, dip-out' guide which shows you how to confidently arrange meetings and produce minutes. It provides hands-on advice about the sections of a meeting as well as tips on how to create an agenda, personal preparation, best practice advice on taking notes and how to improve your accuracy. Brand new chapters of this 4th edition include guidance on using technology to maximize effectiveness and practical help with taking minutes for a variety of different types of meetings. The creating success series of books... With over one million copi...

Cancer preceding Wegener's granulomatosis: a case-control study

DEFF Research Database (Denmark)

Faurschou, Mikkel; Mellemkjaer, Lene; Sorensen, Inge J

2009-01-01

OBJECTIVE: To investigate whether patients with WG have an increased risk of malignancies prior to and/or around the time of the vasculitis diagnosis, as suggested by previous studies. METHODS: A total of 293 WG patients were included in the study. Ten gender- and age-matched controls were selected.......4; 95% CI 1.1, 38) based on two patients, who developed testis cancer >10 years before WG. The overall prevalence of malignancies diagnosed time...... interval (OR 4.0; 95% CI 1.4, 12). CONCLUSIONS: We did not find clear evidence of an increased prevalence of preceding cancer in our WG cohort, indicating that shared risk factors are of minor importance for the excess of malignancies that occur in WG patients after the vasculitis diagnosis. Furthermore...

B7-2 Expressed on EL4 Lymphoma Suppresses Antitumor Immunity by an Interleukin 4–dependent Mechanism

Science.gov (United States)

Stremmel, C.; Greenfield, E.A.; Howard, E.; Freeman, G.J.; Kuchroo, V.K.

1999-01-01

For T cells to become functionally activated they require at least two signals. The B7 costimulatory molecules B7-1 and B7-2 provide the “second signal” pivotal for T cell activation. In this report, we studied the relative roles of B7-1 and B7-2 molecules in the induction of antitumor immunity to the T cell thymoma, EL4. We generated EL4 tumor cells that expressed B7-1, B7-2, and B7-1+B7-2 by transfecting murine cDNAs. Our results demonstrate that EL4–B7-1 cells are completely rejected in syngeneic mice. Unlike EL4–B7-1 cells, we find that EL4–B7-2 cells are not rejected but progressively grow in the mice. A B7-1– and B7-2–EL4 double transfectant was generated by introducing B7-2 cDNA into the EL4–B7-1 tumor line that regressed in vivo. The EL4–B7-1+B7-2 double transfectant was not rejected when implanted into syngeneic mice but progressively grew to produce tumors. The double transfectant EL4 cells could costimulate T cell proliferation that could be blocked by anti–B7-1 antibodies, anti–B7-2 antibodies, or hCTLA4 immunoglobulin, showing that the B7-1 and B7-2 molecules expressed on the EL4 cells were functional. In vivo, treatment of mice implanted with double-transfected EL4 cells with anti–B7-2 monoclonal antibody resulted in tumor rejection. Furthermore, the EL4–B7-2 and EL4–B7-1+B7-2 cells, but not the wild-type EL4 cells, were rejected in interleukin 4 (IL-4) knockout mice. Our data suggests that B7-2 expressed on some T cell tumors inhibits development of antitumor immunity, and IL-4 appears to play a critical role in abrogation of the antitumor immune response. PMID:10075975

Development of a bioprocess to convert PET derived terephthalic acid and biodiesel derived glycerol to medium chain length polyhydroxyalkanoate

Energy Technology Data Exchange (ETDEWEB)

Kenny, Shane T.; Nikodinovic Runic, Jasmina; O' Connor, Kevin E. [University College Dublin (Ireland). School of Biomolecular and Biomedical Sciences; Kaminsky, Walter [Hamburg Univ. (Germany). Inst. of Technical and Macromolecular Chemistry; Woods, Trevor; Babu, Ramesh P. [Dublin Univ. (Ireland). Materials Ireland Polymer Research Center

2012-08-15

Sodium terephthalate (TA) produced from a PET pyrolysis product and waste glycerol (WG) from biodiesel manufacture were supplied to Pseudomonas putida GO16 in a fed-batch bioreactor. Six feeding strategies were employed by altering the sequence of TA and WG feeding. P. putida GO16 reached 8.70 g/l cell dry weight (CDW) and 2.61 g/l PHA in 48 h when grown on TA alone. When TA and WG were supplied in combination, biomass productivity (g/l/h) was increased between 1.3- and 1.7-fold and PHA productivity (g/l/h) was increased 1.8- to 2.2-fold compared to TA supplied alone. The monomer composition of the PHA accumulated from TA or WG was predominantly composed of 3-hydroxydecanoic acid. PHA monomers 3-hydroxytetradeeanoic acid and 3-hydroxytetradecenoic acid were not present in PHA accumulated from TA alone but were present when WG was supplied to the fermentation. When WG was either the sole carbon source or the predominant carbon source supplied to the fermentation the molecular weight of PHA accumulated was lower compared to PHA accumulated when TA was supplied as the sole substrate. Despite similarities in data for the properties of the polymers, PHAs produced with WG present in the PHA accumulation phase were tacky while PHA produced where TA was the sole carbon substrate in the polymer accumulation phase exhibited little or no tackiness at room temperature. The co-feeding of WG to fermentations allows for increased utilisation of TA. The order of feeding of WG and TA has an effect on TA utilisation and polymer properties. (orig.)

12 CFR 908.72 - Appearances and practice in proceedings before the Finance Board.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Appearances and practice in proceedings before the Finance Board. 908.72 Section 908.72 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOUSING FINANCE BOARD ORGANIZATION AND OPERATIONS RULES OF PRACTICE AND PROCEDURE IN HEARINGS ON THE RECORD Rules of Practice Before the Finance Board §...

75 FR 39954 - Oversight of Laboratory Developed Tests; Public Meeting; Change of Meeting Location

Science.gov (United States)

2010-07-13

...] Oversight of Laboratory Developed Tests; Public Meeting; Change of Meeting Location AGENCY: Food and Drug... location for the upcoming public meeting entitled ``Oversight of Laboratory Developed Tests.'' A new... the public meeting, FDA is announcing in this notice a new location for the public meeting. II. New...

75 FR 42125 - Notice of Public Meeting, Eastern Montana Resource Advisory Council Meeting

Science.gov (United States)

2010-07-20

... Public Meeting, Eastern Montana Resource Advisory Council Meeting AGENCY: Bureau of Land Management... Interior, Bureau of Land Management (BLM) Eastern Montana Resource Advisory Council (RAC) will meet as indicated below. DATES: The next regular meeting of the Eastern Montana Resource Advisory Council will be...

75 FR 3489 - Notice of Public Meeting, Eastern Montana Resource Advisory Council Meeting

Science.gov (United States)

2010-01-21

... Public Meeting, Eastern Montana Resource Advisory Council Meeting AGENCY: Bureau of Land Management... Interior, Bureau of Land Management (BLM) Eastern Montana Resource Advisory Council (RAC), will meet as indicated below. DATES: The next regular meeting of the Eastern Montana Resource Advisory Council will be...

75 FR 47312 - Board Meeting; Sunshine Act Meetings

Science.gov (United States)

2010-08-05

... INTER-AMERICAN FOUNDATION Board Meeting; Sunshine Act Meetings Time and Date: August 9, 2010, 8:30 a.m.-5:30 p.m.. Place: 101 Constitution Avenue, Washington, DC 20001. Status: Closed session as provided in 22 CFR 1004.4(f). Matters to be Considered: Executive Session. Portions to be Closed to the...

7 CFR 1944.72 - Application packaging orientation and training.

Science.gov (United States)

2010-01-01

... 7 Agriculture 13 2010-01-01 2009-01-01 true Application packaging orientation and training. 1944... SERVICE, RURAL BUSINESS-COOPERATIVE SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT... Grants § 1944.72 Application packaging orientation and training. Agency approval officials will orient...

CA72-4 e CEA no soro e no lavado peritonial de doentes com câncer gástrico CA72-4 and CEA in serum and peritoneal washing in gastric cancer

Directory of Open Access Journals (Sweden)

Sandra MANDORWSKI

2002-03-01

Full Text Available Racional - O tratamento e o prognóstico dos pacientes com câncer gástrico dependem, principalmente, do estádio clínico. Os marcadores tumorais séricos e do lavado peritonial podem auxiliar a avaliar o risco de recurrência da doença. Casuística e Métodos - Quarenta pacientes com câncer gástrico (11 estádio I ou II e 29 estádio III ou IV e 24 com doença benigna foram estudados prospectivamente. Todos os doentes foram submetidos a laparotomia. O sangue e o lavado peritonial foram colhidos durante o ato cirúrgico, antes da retirada do tumor, para determinação dos marcadores CEA e CA72-4. Resultados - Vinte e cinco por cento e 47,5% dos pacientes com câncer gástrico apresentam elevação dos níveis séricos de CEA e CA72-4. Através das curvas ROC definiram-se os valores de corte dos marcadores no lavado peritonial. Através destas curvas, observaram-se que 60% e 57,5% apresentavam CEA e CA72-4 elevado, respectivamente no grupo com câncer gástrico. Os valores de CEA e CA72-4 foram maiores nos pacientes estádios III e IV. No lavado peritonial, os níveis de CEA foram maiores nos doentes com tumores T3-4. Os valores de CA72-4 no lavado peritonial diferenciaram o grupo controle do grupo com câncer gástrico. Conclusão - O CA72-4 foi o marcador sérico mais sensível no diagnóstico de câncer gástrico. Entretanto, no lavado peritonial, o marcador mais sensível foi o CEA. Os valores de CEA foram superiores nos tumores que ultrapassam a serosa e inferiores nos tumores que se restringem a mucosa e muscular.Background - The treatment and the prognosis of gastric cancer patients depends mainly on clinical stage. Serum and peritoneal tumoral markers levels can be helpful to evaluate individual risk for recurrence. Aims - To evaluate the sensibility of the tumoral markers in the serum and in the peritoneal washing on diagnosis of gastric cancer. Patients and Methods - Forty patients with adenocarcinoma of the stomach (11 stage I or

Amino acids fortification of low-protein diet for broilers under tropical climate: ideal essential amino acids profile

Directory of Open Access Journals (Sweden)

Elmutaz Atta Awad

2014-05-01

Full Text Available A three-week trial was conducted to determine the effect of lowering dietary protein level (DPL with optimal amino acid (AA profile on growth performance, blood metabolites, and relative weights of abdominal fat and internal organs in broiler chickens raised under tropical hot and humid environment. Five isocaloric (3023 metabolisable energy/kg starter (1-21 days experimental diets were formulated in a gradual crude protein (CP decline from 22.2 (control to 16.2% by 1.5% interval. All diets were meeting or exceeding National Research Council recommendations except CP and metabolisable energy. The formulations were also adjusted to contain 1.1 digestible Lys to meet the ideal AA ratios concept. Body weights (BW, weight gains (WG, feed intake and feed conversion ratio of groups with 19.2, 20.7 and 22.2% DPL were not significantly different. However, BW and WG suppressed (P<0.05 with 16.2 and 17.7% DPL. Feeding the 16.2% CP diet significantly reduced serum total protein and uric acid, but increased serum triglyceride (P<0.05. Moreover, relative heart weights increased (P<0.05 but no changes occurred in liver and abdominal fat weights in chicks with 16.2% DPL. In summary, CP of broilers starter (1-21 days diet can be reduced till 19.2% with essential AA fortification and without any adverse effect on growth performance under the hot, humid tropics.

78 FR 22225 - Meeting: African Development Foundation, Board of Directors Executive Session Meeting

Science.gov (United States)

2013-04-15

...;and investigations, committee meetings, agency decisions and rulings, #0;delegations of authority... Executive Session Meeting Meeting: African Development Foundation, Board of Directors Executive Session Meeting Time: Tuesday, April 23, 2013 11:15 a.m. to 2:15 p.m. Place: 1400 Eye Street NW., Suite 1000...

77 FR 42507 - Notice of Public Meeting, Eastern Montana Resource Advisory Council Meeting

Science.gov (United States)

2012-07-19

... Public Meeting, Eastern Montana Resource Advisory Council Meeting AGENCY: Bureau of Land Management... Interior, Bureau of Land Management (BLM) Eastern Montana Resource Advisory Council (RAC) will meet as indicated below. DATES: The next regular meeting of the Eastern Montana RAC will be held on September 19...

77 FR 70807 - Notice of Public Meeting, Eastern Montana Resource Advisory Council Meeting

Science.gov (United States)

2012-11-27

... Public Meeting, Eastern Montana Resource Advisory Council Meeting AGENCY: Bureau of Land Management... Interior, Bureau of Land Management (BLM) Eastern Montana Resource Advisory Council (RAC) will meet as indicated below. DATES: The next regular meeting of the Eastern Montana RAC will be held on December 6, 2012...

77 FR 42760 - Notice of Public Meeting, Eastern Montana Resource Advisory Council Meeting

Science.gov (United States)

2012-07-20

... Public Meeting, Eastern Montana Resource Advisory Council Meeting AGENCY: Bureau of Land Management... Interior, Bureau of Land Management (BLM) Eastern Montana Resource Advisory Council (RAC) will meet as indicated below. DATES: The next regular meeting of the Eastern Montana RAC will be held on September 19...

Nanostructural morphology of plasticized wheat gluten and modified potato starch composites: relationship to mechanical and barrier properties.

Science.gov (United States)

Muneer, Faraz; Andersson, Mariette; Koch, Kristine; Menzel, Carolin; Hedenqvist, Mikael S; Gällstedt, Mikael; Plivelic, Tomás S; Kuktaite, Ramune

2015-03-09

In the present study, we were able to produce composites of wheat gluten (WG) protein and a novel genetically modified potato starch (MPS) with attractive mechanical and gas barrier properties using extrusion. Characterization of the MPS revealed an altered chain length distribution of the amylopectin fraction and slightly increased amylose content compared to wild type potato starch. WG and MPS of different ratios plasticized with either glycerol or glycerol and water were extruded at 110 and 130 °C. The nanomorphology of the composites showed the MPS having semicrystalline structure of a characteristic lamellar arrangement with an approximately 100 Å period observed by small-angle X-ray scattering and a B-type crystal structure observed by wide-angle X-ray scattering analysis. WG has a structure resembling the hexagonal macromolecular arrangement as reported previously in WG films. A larger amount of β-sheets was observed in the samples 70/30 and 30/70 WG-MPS processed at 130 °C with 45% glycerol. Highly polymerized WG protein was found in the samples processed at 130 °C versus 110 °C. Also, greater amounts of WG protein in the blend resulted in greater extensibility (110 °C) and a decrease in both E-modulus and maximum stress at 110 and 130 °C, respectively. Under ambient conditions the WG-MPS composite (70/30) with 45% glycerol showed excellent gas barrier properties to be further explored in multilayer film packaging applications.

28 CFR 540.72 - Statutory restrictions requiring return of commercially published information or material which...

Science.gov (United States)

2010-07-01

....72 Section 540.72 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL... which is distributed or made available through any means or media for a commercial purpose. This...

Various domains of the B-cell regulatory molecule CD72 has diverged at different rates in mammals

DEFF Research Database (Denmark)

Petersen, Cathrine Bie; Hillig, Ann-Britt Nygaard; Fredholm, Merete

2007-01-01

72 has been shown to be a negatively regulating BCR co-receptor. We isolated and sequenced three porcine CD72 transcript variants. Using a pig radiation hybrid panel we found the porcien CD72 gene to be located on chromosome 1q21-28 in a region syntenic to human chromosome 9. The porcine CD72 gene......We report the cloning of the porcine B-cell co-receptor CD72, as well as genomic mapping and examination of transcription. The B-cell receptor (BCR) complex mediates signalling upon antigen recognition by the membrane bound BCR. Several co-receptors modulate this signal positively or negatively. CD...

Report on geotechnical tests with model structures Work Package - Deliverable number: WP 7.2 – D72.2

DEFF Research Database (Denmark)

Gintautas, Tomas; Sørensen, John Dalsgaard

2017-01-01

This report aims to give a comprehensive summary of the geotechnical tests with model structures that have been performed in work package 7.2 task 7.2.2 within the IRPWIND project. The large-scale tests are intended to determine soil-structure interaction effects in order to support probabilistic...... calculations of the reliability of offshore wind turbine support structures. These calculations are mainly performed in work package 7.4 of the IRPWIND project. However, this report already includes the development of a probabilistic model for the axial bearing capacity / resistance that is obtained using...

ACCU MEETING

CERN Multimedia

Chris Onions

2002-01-01

DRAFT Agenda for the meeting to be held on Wednesday 4 December 2002 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Fellows, Associates and Summer Student Programmes Particle Data Book distribution Revoking Computer accounts Equipment insurance on site Reports from ACCU representatives on other committees Users' Office news Any Other Business Dates for meetings in 2003 Agenda for the next meeting Anyone wishing to raise any points under item 12 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch   ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (74837...

ACCU Meeting

CERN Multimedia

PH Department

2011-01-01

DRAFT Agenda for the meeting to be held on Wednesday 15 June 2011 At 9:15 a.m. in room 60-6-002 Chairperson’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Report on services from GS department Update on Safety at CERN Reports from ACCU representatives on other Committees a. Scientific Information Policy Board (SIPB) b. IT Service Review Meeting (ITSRM) c. GS User Commission Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairperson in writing or by e-mail to Michael.Hauschild@cern.ch Michael Hauschild (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in bra...

Association of ghrelin Leu72Met polymorphism with type 2 diabetes mellitus in Chinese population.

Science.gov (United States)

Liu, Jing; Liu, Jia; Tian, Li-min; Liu, Ju-xiang; Bing, Ya-jun; Zhang, Ji-ping; Wang, Yun-Fang; Zhang, Lu-yan

2012-08-10

Ghrelin, a novel endogenous ligand for the growth hormone secretagogue receptor, is considered to implicate the development of the type 2 diabetes mellitus (T2DM). The Leu72Met (+408C>A) polymorphism of the preproghrelin, has been linked to obesity, insulin resistance and diabetes. To investigate the distribution of ghrelin gene Leu72Met polymorphism and its association with the type 2 diabetes mellitus in Chinese population. We conducted a case-control study on 877 patients with T2DM and 864 controls, which were genotyped by the polymerase chain reaction (PCR) technique, denaturing high performance liquid chromatography (DHPLC) and DNA sequence analysis. Laboratory analyses were carried out in the hospital laboratory. No significant difference in the Leu72Met genotype distributions and allele frequency was observed between type 2 diabetes mellitus and controls (both P>0.05). The polymorphism was not associated with T2DM. However, among the T2DM group, the patients carrying Leu72Leu genotype had significantly increased levels of FPG and serum creatinine compared with variant genotypes (Leu72Met and Met72Met) (Ppolymorphism of the preproghrelin gene was not associated with T2DM in Chinese population. However, it may have some roles in the etiology of insulin resistance. Copyright © 2012 Elsevier B.V. All rights reserved.

EDITORIAL: Nano Meets Spectroscopy Nano Meets Spectroscopy

Science.gov (United States)

Birch, David J. S.

2012-08-01

The multidisciplinary two-day Nano Meets Spectroscopy (NMS) event was held at the National Physical Laboratory (NPL), Teddington, UK, in September 2011. The event was planned from the outset to be at the interface of several areas—in particular, spectroscopy and nanoscience, and to bring together topics and people with different approaches to achieving common goals in biomolecular science. Hence the meeting cut across traditional boundaries and brought together researchers using diverse techniques, particularly fluorescence and Raman spectroscopy. Despite engaging common problems, these techniques are frequently seen as mutually exclusive with the two communities rarely interacting at conferences. The meeting was widely seen to have lived up to its billing in good measure. It attracted the maximum capacity of ~120 participants, including 22 distinguished speakers (9 from outside the UK), over 50 posters and a vibrant corporate exhibition comprising 10 leading instrument companies and IOP Publishing. The organizers were Professor David Birch (Chair), Dr Karen Faulds and Professor Duncan Graham of the University of Strathclyde, Professor Cait MacPhee of the University of Edinburgh and Dr Alex Knight of NPL. The event was sponsored by the European Science Foundation, the Institute of Physics, the Royal Society of Chemistry, NPL and the Scottish Universities Physics Alliance. The full programme and abstracts are available at http://sensor.phys.strath.ac.uk/nms/program.php. The programme was quite ambitious in terms of the breadth and depth of scope. The interdisciplinary and synergistic concept of 'X meets Y' played well, cross-fertilization between different fields often being a source of inspiration and progress. Fluorescence and Raman spectroscopy provided the core, but the meeting had little repetition and also attracted contributions on more specialist techniques such as CARS, super-resolution, single molecule and chiral methods. In terms of application the

On the technical, economical and proliferation aspects of the different enrichment techniques

International Nuclear Information System (INIS)

1979-05-01

The report reviews the technical, economic and proliferation aspects of the different enrichment techniques as they are seen by the participants in WG.2. Summary descriptions, theoretical equations and diagrammatic representations are given for the major enrichment technologies. The current availability of enrichment services, the anticipated future demand, and the flexibility of the industry to meet that demand are discussed. Proliferation aspects are assessed and compared for the various technologies. Separate chapters review questions related to the long term assurance of supply and the special needs of developing countries

75 FR 16510 - Meeting of the Advisory Committee; Meeting

Science.gov (United States)

2010-04-01

... recommended for inclusion on future Joint Board examinations in actuarial mathematics, pension law and... closed meeting of the Advisory Committee on Actuarial Examinations. DATES: The meeting will be held on.... SUPPLEMENTARY INFORMATION: Notice is hereby given that the Advisory Committee on Actuarial Examinations will...

78 FR 19008 - Meeting of the Advisory Committee; Meeting

Science.gov (United States)

2013-03-28

... inclusion on future Joint Board examinations in actuarial mathematics, pension law and methodology referred... closed meeting of the Advisory Committee on Actuarial Examinations. DATES: The meeting will be held on.... SUPPLEMENTARY INFORMATION: Notice is hereby given that the Advisory Committee on Actuarial Examinations will...

48 CFR 3052.209-72 - Organizational conflict of interest.

Science.gov (United States)

2010-10-01

... competitive advantage. The nature of the conflict of interest and the limitation on future contracting... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Organizational conflict of... CONTRACT CLAUSES Text of Provisions and Clauses 3052.209-72 Organizational conflict of interest. As...

48 CFR 1252.242-72 - Dissemination of contract information.

Science.gov (United States)

2010-10-01

....242-72 Dissemination of contract information. As prescribed in (TAR) 48 CFR 1242.7000(c), insert the following clause: Dissemination of Contract Information (OCT 1994) The Contractor shall not publish, permit... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Dissemination of contract...

14 CFR 1260.72 - Adherence to original budget estimates.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Adherence to original budget estimates... COOPERATIVE AGREEMENTS General Post-Award Requirements § 1260.72 Adherence to original budget estimates. (a) Although NASA assumes no responsibility for budget overruns, the recipient may spend grant funds without...

77 FR 31894 - Sunshine Act Meeting Notice, Regular Board of Directors Meeting

Science.gov (United States)

2012-05-30

...,Washington, DC 20005. STATUS: Open. CONTACT PERSON FOR MORE INFORMATION: Erica Hall, Assistant Corporate... Meeting Minutes V. Approval of the Finance, Budget and Program Committee Meeting Minutes VI. Approval of the Corporate Administration Committee Meeting Minutes VII. Executive Session VIII. Board Elections...

E-Infrastructure Concertation Meeting

CERN Multimedia

Katarina Anthony

2010-01-01

The 8th e-Infrastructure Concertation Meeting was held in the Globe from 4 to 5 November to discuss the development of Europe’s distributed computing and storage resources.   Project leaders attend the E-Concertation Meeting at the Globe on 5 November 2010. © Corentin Chevalier E-Infrastructures have become an indispensable tool for scientific research, linking researchers to virtually unlimited e-resources like the grid. The recent e-Infrastructure Concertation Meeting brought together e-Science project leaders to discuss the development of this tool in the European context. The meeting was part of an ongoing initiative to develop a world-class e-infrastructure resource that would establish European leadership in e-Science. The e-Infrastructure Concertation Meeting was organised by the Commission Services (EC) with the support of e-ScienceTalk. “The Concertation meeting at CERN has been a great opportunity for e-ScienceTalk to meet many of the 38 new proje...

Reproducibility of Carbon and Water Cycle by an Ecosystem Process Based Model Using a Weather Generator and Effect of Temporal Concentration of Precipitation on Model Outputs

Science.gov (United States)

Miyauchi, T.; Machimura, T.

2014-12-01

GCM is generally used to produce input weather data for the simulation of carbon and water cycle by ecosystem process based models under climate change however its temporal resolution is sometimes incompatible to requirement. A weather generator (WG) is used for temporal downscaling of input weather data for models, where the effect of WG algorithms on reproducibility of ecosystem model outputs must be assessed. In this study simulated carbon and water cycle by Biome-BGC model using weather data measured and generated by CLIMGEN weather generator were compared. The measured weather data (daily precipitation, maximum, minimum air temperature) at a few sites for 30 years was collected from NNDC Online weather data. The generated weather data was produced by CLIMGEN parameterized using the measured weather data. NPP, heterotrophic respiration (HR), NEE and water outflow were simulated by Biome-BGC using measured and generated weather data. In the case of deciduous broad leaf forest in Lushi, Henan Province, China, 30 years average monthly NPP by WG was 10% larger than that by measured weather in the growing season. HR by WG was larger than that by measured weather in all months by 15% in average. NEE by WG was more negative in winter and was close to that by measured weather in summer. These differences in carbon cycle were because the soil water content by WG was larger than that by measured weather. The difference between monthly water outflow by WG and by measured weather was large and variable, and annual outflow by WG was 50% of that by measured weather. The inconsistency in carbon and water cycle by WG and measured weather was suggested be affected by the difference in temporal concentration of precipitation, which was assessed.

International Materials Research Meeting in the Greater Region: “Current Trends in the Characterisation of Materials and Surface Modification”

Science.gov (United States)

2017-10-01

Preface Dear ladies and gentlemen, On 6th and 7th of April 2017 took place the “International Materials Research Meeting in the Greater Region” at the Saarland University, Saarbrücken, Germany. This meeting corresponded to the 9th EEIGM International Conference on Advanced Materials Research and it was intended as a meeting place for researchers of the Greater Region as well as their partners of the different cooperation activities, like the EEIGM program, the ‘Erasmus Mundus’ Advanced Materials Science and Engineering Master program (AMASE), the ‘Erasmus Mundus’ Doctoral Program in Materials Science and Engineering (DocMASE) and the CREATe-Network. On this meeting, 72 participants from 15 countries and 24 institutions discussed and exchanged ideas on the latest trends in the characterization of materials and surface modifications. Different aspects of the material research of metals, ceramics, polymers and biomaterials were presented. As a conclusion of the meeting, the new astronaut of the European Space Agency Dr. Matthias Maurer, who is an alumni of the Saarland University and the EEIGM, held an exciting presentation about his activities. Following the publication of selected papers of the 2009 meeting in Volume 5 and 2012 meeting in Volume 31 of this journal, it is a great pleasure to present this selection of 9 articles to the readers of the IOP Conference Series: Materials Science and Engineering. The editors are thankful to all of the reviewers for reviewing the papers. Special praise is also given to the sponsors of the conference: European Commission within the program Erasmus Mundus (AMASE and DocMASE), Erasmus+ (AMASE), and Horizon2020 (CREATe-Network, Grant agreement No 644013): the DAAD (Alumni Program), and the German-French University (PhD-Track). List of Author signatures, Conference topics, Organization, Conference impressions and list of the participants are available in this PDF.

Clostridium XIV Meeting

Energy Technology Data Exchange (ETDEWEB)

Lynd, Lee

2016-08-28

The 14th biannual Clostridium meeting was held at Dartmouth College from August 28 through 31, 2016. As noted in the meeting program (http://clostridiumxiv.com/wp-content/uploads/2016/09/Clostridium_XIV_program.pdf). the meeting featured 119 registered attendees, 33 oral presentations, 5 of which were given by younger presenters, 40 posters, and 2 keynote presentations, with strong participation by female and international scientists.

77 FR 71828 - Meeting of the Advisory Committee; Meeting

Science.gov (United States)

2012-12-04

... recommended for inclusion on future Joint Board examinations in actuarial mathematics and methodology referred... meeting of the Advisory Committee on Actuarial Examinations (portions of which will be open to the public... Committee on Actuarial Examinations will meet at the Internal Revenue Service, 1111 Constitution Avenue NW...

75 FR 76486 - Meeting of the Advisory Committee; Meeting

Science.gov (United States)

2010-12-08

... that may be recommended for inclusion on future Joint Board examinations in actuarial mathematics and... meeting of the Advisory Committee on Actuarial Examinations (portions of which will be open to the public... the Advisory Committee on Actuarial Examinations will meet at the Internal Revenue Service, 1111...

CELLULAR LOCALIZATION AND EXPRESSION OF pygo DURING DROSOPHILA DEVELOPMENT

Institute of Scientific and Technical Information of China (English)

LINXin-da; LINXin-hua; CHENGJia-an

2003-01-01

Wg/Wnt signaling is a key signaling pathway in Drosophila. Many genes involved in Wingless(wg) signal transduction pathway downstream of Wg, or it'' s vertebrate Wg homologue Wnt, have been identified.Transduction of the Wg signal downstream of Wg is mediated by nuclear TCF/LEF-1, through association with Ar-madillo (Arm)/β-catenin. Pygopus (pygo) is a new identified component in this pathway . Cellular localization experiment showed that pygo was expressed specifically in the nucleus. The expression profile of pygo in embryos was examined using in situ hybridization. Although pygo expressed ubiquitously in the embryos, it expressed at relatively high level in pre-blastoderm embryos which indicate a high degree of maternally provided message, fol-lowed by a low level of ubiquitous zygotic expression. This continues into larval tissues (including wing disc, eye disc and leg disc), where pygo appears to be expressed at low level. Comparison of pygo expression levels, in the wing disc, eye disc and leg disc, showed pygo expression level in the wing disc pouch and leg disc were rela-tive higher.

75 FR 22168 - Region VI-Houston District; Advisory Council Meeting; Public Meeting

Science.gov (United States)

2010-04-27

... SMALL BUSINESS ADMINISTRATION Region VI--Houston District; Advisory Council Meeting; Public Meeting The Small Business Administration-Region VI--Houston Advisory Council, located in the geographical Area of Houston, Texas will hold a federal public meeting on--Thursday, May 20, 2010, starting at 10:30...

Scientific impact of presentations from the EURAPS and the AAPS meetings

DEFF Research Database (Denmark)

Khorasani, Hoda; Lassen, Mats Højbjerg; Kuzon, William

2017-01-01

and for English speaking vs. non-English speaking countries. RESULTS: Seventy-two percent (n = 246) of the abstracts from the AAPS were published in peer-reviewed journals. The most published subspecialty was "Craniofacial surgery" followed by "Breast surgery." Mean time to publication was 22.1 months (range -72...... was 17.3 months (range -67-111 months). The most common journal for publication was PRS. Differences between the two societies' publication status were not observed (p = 0.157), but EURAPS abstracts had a significantly shorter time to publication (p = 0.007). Differences between English-speaking and non-English-speaking......INTRODUCTION: Presentation at scientific meetings is the usual first step to communicate new research findings. However, without subsequent, peer-reviewed publication, the wider propagation and the permanent documentation of important scholarly work may be lost. Our aim was to analyze and compare...

STS-72 Flight Day 2

Science.gov (United States)

1996-01-01

On this second day of the STS-72 mission, the flight crew, Cmdr. Brian Duffy, Pilot Brent W. Jett, and Mission Specialists Leroy Chiao, Daniel T. Barry, Winston E. Scott, and Koichi Wakata (NASDA), awakened to music from the motion picture 'Star Wars.' The crew performed a systems checkout, prepared for the retrieval of the Japanese Space Flyer Unit (SFU), tested the spacesuits for the EVA, and activated some of the secondary experiments. An in-orbit news interview was conducted with the crew via satellite downlinking. Questions asked ranged from the logistics of the mission to the avoidance procedures the Endeavour Orbiter performed to miss hitting the inactive Air Force satellite, nicknamed 'Misty' (MSTI). Earth views included cloud cover, several storm systems, and various land masses with several views of the shuttle's open cargo bay in the foreground.

Analysis of the Use and Impact of Twitter During American Society of Clinical Oncology Annual Meetings From 2011 to 2016: Focus on Advanced Metrics and User Trends.

Science.gov (United States)

Pemmaraju, Naveen; Thompson, Michael A; Mesa, Ruben A; Desai, Tejas

2017-07-01

The use of social media, in particular Twitter, has substantially increased among health care stakeholders in the field of hematology and oncology, with an especially sharp increase in the use of Twitter during times of major national meetings. The most attended meeting in the oncology field is the ASCO annual meeting. Little is known about the detailed metrics involved in the use, volume, and impact of Twitter during the ASCO annual meeting. We conducted a retrospective review of tweets during the ASCO annual meetings from 2011 to 2016. The total data set encompassed 190,732 tweets from 39,745 authors over six consecutive ASCO meetings from 2011 to 2016 (inclusive). Tweets, all publically available, were collected by Nephrology On-Demand Analytics. The number of individual authors increased from 1,429 during the 2011 ASCO meeting to 15,796 during the 2016 ASCO meeting, an 11-fold increase over the total 5-year period. There was a notable increase in tweets from the 2011 ASCO meeting (n = 7,746) to the 2016 ASCO meeting (n = 72,698), a nine-fold increase during the study period. The most commonly tweeted term or topic changed over time, generally reflecting the breakthroughs of each designated year; these terms were "melanoma" for both the 2011 and 2012 ASCO meetings; "breast cancer" for the 2013 ASCO meeting; "lung cancer" for the 2014 ASCO meeting; and "ImmunOnc" or "immunotherapy/immuno-oncology" for both the 2015 and 2016 ASCO meetings. The use of Twitter among health care stakeholders during the ASCO meeting has markedly increased over time, demonstrating the increasing role of social media in the dissemination of findings at the most highly attended hematology and oncology conference of the year.

IAEA Newsbriefs. V. 11, no. 3(72). Jul-Aug 1996

International Nuclear Information System (INIS)

1996-01-01

This issue gives brief information on the following topics: Board moves toward finalizing Safeguards Measures, IAEA General Conference opens in Vienna, 16 September, Uranium Resources, Production and Demand, Atoms in Agriculture, Controlling Insect Pests, IAEA Meetings, Nuclear Power as an Energy Source, Nuclear Electricity Generation in OECD Countries, Radioactive Waste Safety, Summit Meeting, Mururoa Radiological Study, and other short information

21 CFR 341.72 - Labeling of antihistamine drug products.

Science.gov (United States)

2010-04-01

..., unless directed by a doctor, if you have a breathing problem such as emphysema or chronic bronchitis, or... Section 341.72 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... product if you are taking sedatives or tranquilizers, without first consulting your doctor. Use caution...

48 CFR 1552.223-72 - Care of laboratory animals.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Care of laboratory animals... Care of laboratory animals. As prescribed in 1523.303-72, insert the following clause: Care of Laboratory Animals (OCT 2000) (a) Before undertaking performance of any contract involving the use of...

47 CFR 3.72 - Grounds for further enforcement action.

Science.gov (United States)

2010-10-01

... OF ACCOUNTING AUTHORITIES IN MARITIME AND MARITIME MOBILE-SATELLITE RADIO SERVICES Enforcement § 3.72... forfeiture, suspension or cancellation of an accounting authority certification, if it is determined that the... any subsequent six month period; (2) Illegal activity or fraud; (3) Non-payment or late payment to a...

Experimental transonic flutter characteristics of two 72 deg-sweep delta-wing models

Science.gov (United States)

Doggett, Robert V., Jr.; Soistmann, David L.; Spain, Charles V.; Parker, Ellen C.; Silva, Walter A.

1989-01-01

Transonic flutter boundaries are presented for two simple, 72 deg. sweep, low-aspect-ratio wing models. One model was an aspect-ratio 0.65 delta wing; the other model was an aspect-ratio 0.54 clipped-delta wing. Flutter boundaries for the delta wing are presented for the Mach number range of 0.56 to 1.22. Flutter boundaries for the clipped-delta wing are presented for the Mach number range of 0.72 to 0.95. Selected vibration characteristics of the models are also presented.

Design and testing of Ground Penetrating Radar equipment dedicated for civil engineering applications: ongoing activities in Working Group 1 of COST Action TU1208

Science.gov (United States)

Pajewski, Lara; Manacorda, Guido; Persico, Raffaele

2015-04-01

This work aims at presenting the ongoing research activities carried out in Working Group 1 'Novel GPR instrumentation' of the COST (European COoperation in Science and Technology) Action TU1208 'Civil Engineering Applications of Ground Penetrating Radar' (www.GPRadar.eu). The principal goal of the COST Action TU1208 is to exchange and increase scientific-technical knowledge and experience of GPR techniques in civil engineering, simultaneously promoting throughout Europe the effective use of this safe and non-destructive technique in the monitoring of infrastructures and structures. Working Group 1 (WG1) of the Action focuses on the development of innovative GPR equipment dedicated for civil engineering applications. It includes three Projects. Project 1.1 is focused on the 'Design, realisation and optimisation of innovative GPR equipment for the monitoring of critical transport infrastructures and buildings, and for the sensing of underground utilities and voids.' Project 1.2 is concerned with the 'Development and definition of advanced testing, calibration and stability procedures and protocols, for GPR equipment.' Project 1.3 deals with the 'Design, modelling and optimisation of GPR antennas.' During the first year of the Action, WG1 Members coordinated between themselves to address the state of the art and open problems in the scientific fields identified by the above-mentioned Projects [1, 2]. In carrying our this work, the WG1 strongly benefited from the participation of IDS Ingegneria dei Sistemi, one of the biggest GPR manufacturers, as well as from the contribution of external experts as David J. Daniels and Erica Utsi, sharing with the Action Members their wide experience on GPR technology and methodology (First General Meeting, July 2013). The synergy with WG2 and WG4 of the Action was useful for a deep understanding of the problems, merits and limits of available GPR equipment, as well as to discuss how to quantify the reliability of GPR results. An

Hydrogen Contractors Meeting

Energy Technology Data Exchange (ETDEWEB)

Fitzsimmons, Tim [Dept. of Energy (DOE), Washington DC (United States). Office of Basic Energy Sciences. Division of Materials Sciences and Engineering

2006-05-16

This volume highlights the scientific content of the 2006 Hydrogen Contractors Meeting sponsored by the Division of Materials Sciences and Engineering (DMS&E) on behalf of the Office of Basic Energy Sciences (BES) of the U. S. Department of Energy (DOE). Hydrogen Contractors Meeting held from May 16-19, 2006 at the Crystal Gateway Marriott Hotel Arlington, Virginia. This meeting is the second in a series of research theme-based Contractors Meetings sponsored by DMS&E held in conjunction with our counterparts in the Office of Energy Efficiency and Renewable Energy (EERE) and the first with the Hydrogen, Fuel Cells and Infrastructure Technologies Program. The focus of this year’s meeting is BES funded fundamental research underpinning advancement of hydrogen storage. The major goals of these research efforts are the development of a fundamental scientific base in terms of new concepts, theories and computational tools; new characterization capabilities; and new materials that could be used or mimicked in advancing capabilities for hydrogen storage.

Where Times Meet

Directory of Open Access Journals (Sweden)

Theodore R. Schatzki

2005-01-01

Full Text Available This essay pursues two goals: (1 to argue that two fundamental types of time—the time of objective reality and “the time of the soul”—meet in human activity and history and (2 to defend the legitimacy of calling a particular version of the second type a kind of time. The essay begins by criticizing Paul Ricoeur’s version of the claim that times of these two sorts meet in history. It then presents an account of human activity based on Heidegger’s Being and Time, according to which certain times of the two types—existential temporality and succession—meet in human activity. The legitimacy of calling existential temporality a kind of time is then defended via an expanded analysis of activity that examines where the two times meet there. The concluding section briefly considers a conception of historical time due to David Carr before showing why history is a broader domain encompassing human activity where the two times meet.

75 FR 28062 - Meeting of the Advisory Committee; Meeting

Science.gov (United States)

2010-05-19

... questions which may be recommended for inclusion on future Joint Board examinations in actuarial mathematics... meeting of the Advisory Committee on Actuarial Examinations (a portion of which will be open to the public... the Advisory Committee on Actuarial Examinations will meet in at the Internal Revenue Service Building...

Loss of function of C9orf72 causes motor deficits in a zebrafish model of amyotrophic lateral sclerosis.

Science.gov (United States)

Ciura, Sorana; Lattante, Serena; Le Ber, Isabelle; Latouche, Morwena; Tostivint, Hervé; Brice, Alexis; Kabashi, Edor

2013-08-01

To define the role that repeat expansions of a GGGGCC hexanucleotide sequence of the C9orf72 gene play in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). A genetic model for ALS was developed to determine whether loss of function of the zebrafish orthologue of C9orf72 (zC9orf72) leads to abnormalities in neuronal development. C9orf72 mRNA levels were quantified in brain and lymphoblasts derived from FTLD and ALS/FTLD patients and in zebrafish. Knockdown of the zC9orf72 was performed using 2 specific antisense morpholino oligonucleotides to block transcription. Quantifications of spontaneous swimming and tactile escape response, as well as measurements of axonal projections from the spinal cord, were performed. Significantly decreased expression of C9orf72 transcripts in brain and lymphoblasts was found in sporadic FTLD and ALS/FTLD patients with normal-size or expanded hexanucleotide repeats. The zC9orf72 is selectively expressed in the developing nervous system at developmental stages. Loss of function of the zC9orf72 transcripts causes both behavioral and cellular deficits related to locomotion without major morphological abnormalities. These deficits were rescued upon overexpression of human C9orf72 mRNA transcripts. Our results indicate C9orf72 haploinsufficiency could be a contributing factor in the spectrum of ALS/FTLD neurodegenerative disorders. Loss of function of the zebrafish orthologue of zC9orf72 expression in zebrafish is associated with axonal degeneration of motor neurons that can be rescued by expressing human C9orf72 mRNA, highlighting the specificity of the induced phenotype. These results reveal a pathogenic consequence of decreased C9orf72 levels, supporting a loss of function mechanism of disease. © 2013 American Neurological Association.

Introducing the AAS Working Group on Astroinformatics and Astrostatistics

Science.gov (United States)

Ivezic, Zeljko

2014-01-01

In response to two White Papers submitted to the Astro2010 Decadal Survey (1,2), a new AAS Working Group on Astroinformatics and Astrostatistics (WGAA) has been approved by the AAS Council at the 220th Meeting, June 2012, in Anchorage. The motivation for this WG is the growing importance of the interface between astronomy and various branches of applied mathematics, computer science and the emerging field of data science. With the new data-intensive projects envisioned for the coming decade, the need for advice derived from the focused attention of a group of AAS members who work in these areas is bound to increase. The Working Group is charged with spreading awareness of rapidly advancing computational techniques, sophsticated statistical methods, and highly capble software to further the goals of astronomical and astrophysical research. The three main strategic goals adopted by the WGAA Steering Committee for the next few years are to: (i) develop, organize and maintain methodological resources (such as software tools, papers, books, and lectures); (ii) enhance human resources (such as foster the creation of career paths, establish a Speakers' Bureau, establish and maintain an archived discussion forum, enable periodic news distribution); and (iii) organize topical meetings. The WGAA Steering Committee at this time includes twelve members: Kirk Borne, George Djorgovski, Eric Feigelson, Eric Ford, Alyssa Goodman, Joe Hilbe, Zeljko Ivezic (chair), Ashish Mahabal, Aneta Siemiginowska, Alex Szalay, Rick White, and Padma Yanamandra-Fisher. I will summarize our accomplishments since July 2012. (1) Astroinformatics: A 21st Century Approach to Astronomy (Borne & 90 coauthors), (2) The Astronomical Information Sciences: A Keystone for 21st-Century Astronomy (Loredo & 72 coauthors)

The metabolic signature of C9ORF72-related ALS: FDG PET comparison with nonmutated patients

Energy Technology Data Exchange (ETDEWEB)

Cistaro, Angelina; Fania, Piercarlo [Positron Emission Tomography Center IRMET S.p.A, Torino (Italy); Pagani, Marco [Institute of Cognitive Sciences and Technologies, Consiglio Nazionale delle Ricerche (CNR), Rome (Italy); Karolinska Hospital, Department of Nuclear Medicine, Stockholm (Sweden); Montuschi, Anna; Moglia, Cristina; Canosa, Antonio [University of Torino, ' Rita Levi Montalcini' Department of Neuroscience, Torino (Italy); Calvo, Andrea; Lopiano, Leonardo [University of Torino, ' Rita Levi Montalcini' Department of Neuroscience, Torino (Italy); Neuroscience Institute of Turin, Turin (Italy); Restagno, Gabriella; Brunetti, Maura [Azienda Ospedaliera Citta della Salute e della Scienza, Molecular Genetics Unit, Department of Clinical Pathology, Torino (Italy); Traynor, Bryan J. [National Institute on Ageing, National Institutes of Health, Neuromuscular Diseases Research Unit, Laboratory of Neurogenetics, Bethesda, MD (United States); Nobili, Flavio [University of Genova, Clinical Neurophysiology Unit, Department of Neurosciences, Ophthalmology and Genetics, Genova (Italy); Carrara, Giovanna; Valentini, M.C. [Azienda Ospedaliera Citta della Salute e della Scienza, Department of Neuroradiology, Torino (Italy); Chio, Adriano [University of Torino, ' Rita Levi Montalcini' Department of Neuroscience, Torino (Italy); Neuroscience Institute of Turin, Turin (Italy); ALS Center, ' Rita Levi Montalcini' Department of Neuroscience, Torino (Italy)

2014-05-15

Recently, a GGGGCC hexanucleotide repeat expansion in the C9ORF72 gene, located on chromosome 9p21 has been demonstrated to be the commonest cause of familial amyotrophic lateral sclerosis (ALS) and to account for 5 to 10 % of apparently sporadic ALS. Relatively little is known about the brain metabolism profile of patients carrying the expansion. Our aim was to identify the [{sup 18}F]FDG PET profile in ALS patients with the C9ORF72 expansion (C9ORF72-ALS). Fifteen C9ORF72-ALS patients were compared with 12 patients with ALS and comorbid frontotemporal dementia (FTD) without the C9ORF72 expansion (ALS-FTD) and 30 cognitively normal patients with ALS without mutations of ALS-related genes (sALS). The three groups were then cross-matched to 40 neurologically normal controls. All patients underwent FDG PET within 4 months of diagnosis. The C9ORF72-ALS patients compared with the sALS patients showed significant hypometabolism in the anterior and posterior cingulate cortex, insula, caudate and thalamus, the left frontal and superior temporal cortex, and hypermetabolism in the midbrain, bilateral occipital cortex, globus pallidus and left inferior temporal cortex. The ALS-FTD patients compared with the sALS patients showed more limited hypometabolic areas, including the orbitofrontal, prefrontal, anterior cingulate and insular cortex, and hypermetabolic areas, including the bilateral occipital cortex, the left precentral and postcentral cortex and superior temporal gyrus. The C9ORF72-ALS patients compared with the ALS-FTD patients showed hypometabolism in the left temporal cortex. ALS patients with the C9ORF72 hexanucleotide repeat expansion had a more widespread central nervous system involvement than ALS patients without genetic mutations, with or without comorbid FTD, consistent with their more severe clinical picture. (orig.)

The metabolic signature of C9ORF72-related ALS: FDG PET comparison with nonmutated patients

International Nuclear Information System (INIS)

Cistaro, Angelina; Fania, Piercarlo; Pagani, Marco; Montuschi, Anna; Moglia, Cristina; Canosa, Antonio; Calvo, Andrea; Lopiano, Leonardo; Restagno, Gabriella; Brunetti, Maura; Traynor, Bryan J.; Nobili, Flavio; Carrara, Giovanna; Valentini, M.C.; Chio, Adriano

2014-01-01

Recently, a GGGGCC hexanucleotide repeat expansion in the C9ORF72 gene, located on chromosome 9p21 has been demonstrated to be the commonest cause of familial amyotrophic lateral sclerosis (ALS) and to account for 5 to 10 % of apparently sporadic ALS. Relatively little is known about the brain metabolism profile of patients carrying the expansion. Our aim was to identify the [ 18 F]FDG PET profile in ALS patients with the C9ORF72 expansion (C9ORF72-ALS). Fifteen C9ORF72-ALS patients were compared with 12 patients with ALS and comorbid frontotemporal dementia (FTD) without the C9ORF72 expansion (ALS-FTD) and 30 cognitively normal patients with ALS without mutations of ALS-related genes (sALS). The three groups were then cross-matched to 40 neurologically normal controls. All patients underwent FDG PET within 4 months of diagnosis. The C9ORF72-ALS patients compared with the sALS patients showed significant hypometabolism in the anterior and posterior cingulate cortex, insula, caudate and thalamus, the left frontal and superior temporal cortex, and hypermetabolism in the midbrain, bilateral occipital cortex, globus pallidus and left inferior temporal cortex. The ALS-FTD patients compared with the sALS patients showed more limited hypometabolic areas, including the orbitofrontal, prefrontal, anterior cingulate and insular cortex, and hypermetabolic areas, including the bilateral occipital cortex, the left precentral and postcentral cortex and superior temporal gyrus. The C9ORF72-ALS patients compared with the ALS-FTD patients showed hypometabolism in the left temporal cortex. ALS patients with the C9ORF72 hexanucleotide repeat expansion had a more widespread central nervous system involvement than ALS patients without genetic mutations, with or without comorbid FTD, consistent with their more severe clinical picture. (orig.)

45 CFR 2553.72 - What are project funding requirements?

Science.gov (United States)

2010-10-01

... local funding sources during the first three years of operations; or (2) An economic downturn, the... sources of local funding support; or (3) The unexpected discontinuation of local support from one or more... 45 Public Welfare 4 2010-10-01 2010-10-01 false What are project funding requirements? 2553.72...

75 FR 52303 - Notice of Meeting; Siskiyou Resource Advisory Committee Meeting at New Location

Science.gov (United States)

2010-08-25

... DEPARTMENT OF AGRICULTURE Forest Service Notice of Meeting; Siskiyou Resource Advisory Committee Meeting at New Location SUMMARY: The Siskiyou County Resource Advisory Committee (RAC) will hold its last two meetings in 2010 at a new location. DATES: The meetings will be held on September 20 and October...

Lingual infarction in Wegener's Granulomatosis: A case report and review of the literature

Directory of Open Access Journals (Sweden)

Brizman Eitan

2008-08-01

Full Text Available Abstract Wegener's granulomatosis (WG is a multi-system disease, characterised by the triad of necrotising granulomata affecting the upper and lower respiratory tracts, disseminated vasculitis and glomerulonephritis. Oral lesions are associated with up to 50% of cases, although are rare as a presenting feature. The most common oral lesions associated with WG are ulceration and strawberry gingivitis. We review the literature regarding oral manifestations of WG and present a case of lingual infarction, an extremely rare oral lesion associated with WG, in a severe, rapidly progressive and ultimately fatal form of the disease.

ACCU MEETING

CERN Multimedia

Chris Onions (Secretary)

2001-01-01

DRAFT Agenda for the meeting to be held on Wednesday 5 December 2001 At 9:15 a.m. in room 60-6-002 1. Chairman's remarks 2. Adoption of the agenda 3. Minutes of the previous meeting 4. Matters arising 5. News from the CERN Management 6. Housing 7. Restaurant Surveillance Committee 8. Users' Office news 9. Election of ACCU chairman 10. Any Other Business 11. Dates for meetings in 2002 12. Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria  W. Adam  (71661) Belgium  G. Wilquet  (74664) Bulgaria  R. Tzenov  (77958) Czech Republic  P. Závada&am...

ACCU MEETING

CERN Multimedia

Chris Onions (Secretary)

2001-01-01

DRAFT Agenda for the meeting to be held on Wednesday 5 December 2001 At 9:15 a.m. in room 60-6-002 1. Chairman's remarks 2. Adoption of the agenda 3. Minutes of the previous meeting 4. Matters arising 5. News from the CERN Management 6. Housing 7. Restaurant Surveillance Committee 8. Users' Office news 9. Election of ACCU chairman 10. Any Other Business 11. Dates for meetings in 2002 12. Agenda for the next meetingAnyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Republic P. Závada (75877) Denmark A. Waananen (75941) Finland A. Kiiskinen (79387) Fr...

ACCU MEETING

CERN Multimedia

2000-01-01

DRAFT Agenda for the meeting to be held on Wednesday 6 December 2000 At 10 a.m. in the 6th floor Conference Room, Main Building Chairman's remarks Adoption of the agenda News from the CERN Management Minutes of the previous meeting Matters arising Equal Opportunities at CERN The Summer Student programme CERN Programme for Physics High School Teachers Users' Office News Any Other Business Dates for Meetings in 2001 Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Secretary in writing via the CERN Users' Office or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets) :   Austria G. Neuhofer (74094) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958)...

ACCU MEETING

CERN Multimedia

Chris Onions (Secretary)

2000-01-01

DRAFT Agenda for the meeting to be held on Wednesday 6 December 2000 At 10 a.m. in the 6th floor Conference Room, Main Building Chairman's remarks Adoption of the agenda News from the CERN Management Minutes of the previous meeting Matters arising Equal Opportunities at CERN The Summer Student programme CERN Programme for Physics High School Teachers Users' Office News Any Other Business Dates for Meetings in 2001 Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Secretary in writing via the CERN Users' Office or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets) : Austria G. Neuhofer (74094) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Re...

9 CFR 72.21 - Animals infested with or exposed to ticks subject to same restrictions as cattle.

Science.gov (United States)

2010-01-01

... ticks subject to same restrictions as cattle. 72.21 Section 72.21 Animals and Animal Products ANIMAL AND... (INCLUDING POULTRY) AND ANIMAL PRODUCTS TEXAS (SPLENETIC) FEVER IN CATTLE § 72.21 Animals infested with or exposed to ticks subject to same restrictions as cattle. Animals other than cattle which are infested with...

77 FR 55455 - Approval for Manufacturing Authority Foreign-Trade Zone 72, Brevini Wind USA, Inc., (Wind Turbine...

Science.gov (United States)

2012-09-10

... Authority Foreign-Trade Zone 72, Brevini Wind USA, Inc., (Wind Turbine Gear Boxes), Yorktown, IN Pursuant to... Wind USA, Inc., within FTZ 72 in Yorktown, Indiana (FTZ Docket 54-2011, filed 8-11-2011); Whereas... procedures within FTZ 72 on behalf of Brevini Wind USA, Inc., as described in the application and Federal...

Using of Glass Wastes as a Fine Aggregate in Concrete Mixture

Directory of Open Access Journals (Sweden)

Mohammad F. Al-Deen

2013-04-01

Full Text Available In this study, the waste glass (WG is considered as a fine aggregate in the concretemixture. WG is used after grinding to size according to Iraqi sand specificationsNo.45. The waste glass has been used instead of sand in different proportions whichare 0%, 33%, 66% and 100%. The effects of WG on compressive strength of theconcrete and unit weight are analysed. As results of this study, WG is determined tohave a significant effect upon the reduction of its compressive strength and there is asignificant decreasing of its unit weight. As for cost analysis, it was determined tolower the cost of concrete production. This study was an environmental one inconsideration of the fact that WG could be used in the concrete as fine aggreagateswithout the need for a high cost or rigorous energy.

Confinement of the antitrust control of abuse in the energy sector. At the same time comment to OLG Duesseldorf from 19th October, 2011. Reference VI-3 Kart 1/11 (V) - GAG Ahrensburg; Grenzen der kartellrechtlichen Missbrauchskontrolle im Energiebereich. Zugleich Anmerkung zu OLG Duesseldorf v. 19.10.2011. Az. VI-3 Kart 1/11 (V) - GAG Ahrensburg

Energy Technology Data Exchange (ETDEWEB)

Weyer, Hartmut [Technische Univ. Clausthal, Clausthal-Zellerfeld (Germany)

2012-10-15

Up to the amendment of the Energy Economy Law (EnWG) 2005 the legislator permitted parallel applicability of the Energy Economy law as well as the Restriction of Competition (GWB) to energy situations. Based on the GWB, especially in procedures by competition authorities key decisions on the reliable behaviour of operators of power distribution systems and natural gas distribution systems were disposed. This approach was restricted by the amendment of the EnWG 2005 with the introduction of paragraph 111 EnWG. In compliance with this, this restriction was implemented in paragraph 130 sect. 3 GWB. From now on, paragraph 111 Sect. 1 and 2 EnWG exclude the antitrust control of abuse according to the paragraphs 19, 20 and 29 GWB. With this, the competence of the cartel authorities are excluded in favour of the regulatory legal prescriptions of the EnWG.

Geneza i ewolucja wywiadu gospodarczego. Część pierwsza

Directory of Open Access Journals (Sweden)

Adriana Moryś

2011-05-01

Full Text Available Artykuł poświęcony jest genezie wywiadu i wywiadu gospodarczego (WG – rozumianego jako legalny i etyczny proces gromadzenia, opracowania i dystrybucji informacji strategicznych, pochodzących z zewnętrznego i wewnętrznego otoczenia przedsiębiorstwa. Przedstawia różnice między wywiadem gospodarczym państwowym, wywiadem gospodarczym przedsiębiorstw, oraz wywiadem białym i czarnym (szpiegostwo. Opisuje warunki i czynniki, tj. demokracja, kapitalizm, rynek informacji, społeczeństwo informacyjne i nowe technologie, i ich wpływ na WG. Omawia historię i stan WG w Polsce. Wskazuje najważniejsze polskie publikacje z zakresu WG. Poza rysem historycznym WG tekst porusza kwestie związane z rolą informacji we współczesnym świecie.

Shape study of the N=Z waiting-point nucleus 72Kr via beta decay

CERN Document Server

Briz Monago, Jose Antonio; Nácher González, Enrique

The Ph.D. thesis entitled “Shape study of the N=Z waiting-point nucleus 72Kr via beta decay” is devoted to the study of the shape of the ground state of the 72Kr nucleus. It is an N=Z nucleus in the mass region A~70-80 where shape transitions and the shape coexistence phenomena have been identified. Furthermore, this nucleus participates in the rp-process as a waiting point due to the slowdown of the process taking place at the arrival to this nucleus. The study of the properties of this nucleus is interesting from the Nuclear Structure point of view, for the phenomena occurring in its mass region and have been predicted for it, and from the Nuclear Astrophysics for the accurate performance of astrophysical calculations. The β+/EC decay of the 72Kr nucleus has been studied through two complementary experiments at the ISOLDE facility at CERN in Geneva (Switzerland). In one of them, the low-spin structure of the daughter nucleus, 72Br, has been revised via conversion electron spectroscopy where the convers...

June 1992 Hall B collaboation meeting

International Nuclear Information System (INIS)

Dennis, L.

1992-01-01

The Hall B collaboration meeting at the CEBAF 1992 Summer Workshop consisted of technical and physics working group meetings, a special beam line devices working group meeting the first meeting of the membership committee, a technical representatives meeting and a full collaboration meeting. Highlights of these meetings are presented in this report

Inactivation of Lipase and Lipoxygenase of Wheat Germ with Temperature-Controlled Short Wave Infrared Radiation and Its Effect on Storage Stability and Quality of Wheat Germ Oil.

Science.gov (United States)

Li, Bo; Zhao, Lina; Chen, Hongjian; Sun, Dewei; Deng, Boxin; Li, Jinwei; Liu, Yuanfa; Wang, Fei

2016-01-01

Wheat germ (WG) is quite susceptible to deterioration due to the presence of lipase (LA) and lipoxygenase (LOX). Therefore it is indispensable to adopt a stabilization step to decrease the activity of LA and LOX while retaining a maximum level of nutrients. But over-drying can make foodstuffs more susceptible to autoxidation. So a stabilization protocol for inactivating LA and LOX of WG with a temperature- controlled short wave infrared (SIR) radiation system was adopted to retard its rancidity and retain a maximum level of fat-soluble nutrients. Meanwhile, the critical storage water activity (Aw) of WG for inhibiting both hydrolytic and oxidative rancidity was appraised. Results indicate that WG irradiated at 90°C for 20 min acquired the optimal stabilization effect, and its residual LA and LOX activity were 18.02% and 19.21%, respectively. At this condition, the free fatty acids (FFA) content and peroxide value (PV) increment of WG oil at 40°C remained below 5% and 2.24 meq O2/kg for 60 days, respectively. The residual Aw of this WG sample was 0.13, and it is near the Aw corresponding to its monolayer. No significant decrease of fatty acids was observed during SIR processing, while about 96.42% of its original tocopherols still retained in WG treated at 90°C for 20 min.

41 CFR 105-72.505 - Cost and price analysis.

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Cost and price analysis... § 105-72.505 Cost and price analysis. Some form of cost or price analysis shall be made and documented in the procurement files in connection with every procurement action. Price analysis may be...

42 CFR 418.72 - Condition of participation: Physical therapy, occupational therapy, and speech-language pathology.

Science.gov (United States)

2010-10-01

..., occupational therapy, and speech-language pathology. 418.72 Section 418.72 Public Health CENTERS FOR MEDICARE... therapy, occupational therapy, and speech-language pathology. Physical therapy services, occupational therapy services, and speech-language pathology services must be available, and when provided, offered in...

78 FR 76627 - Health Information Technology Standards Committee Advisory Meeting: Notice of Meeting

Science.gov (United States)

2013-12-18

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Health Information Technology Standards Committee Advisory Meeting: Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology... committee of the Office of the National Coordinator for Health Information Technology (ONC). These meeting...

Logic Meeting

CERN Document Server

Tugué, Tosiyuki; Slaman, Theodore

1989-01-01

These proceedings include the papers presented at the logic meeting held at the Research Institute for Mathematical Sciences, Kyoto University, in the summer of 1987. The meeting mainly covered the current research in various areas of mathematical logic and its applications in Japan. Several lectures were also presented by logicians from other countries, who visited Japan in the summer of 1987.

75 FR 56608 - Agency Meeting

Science.gov (United States)

2010-09-16

... SECURITIES AND EXCHANGE COMMISSION Agency Meeting Federal Register Citation of Previous Announcement: [To be published] Status: Open Meeting. Place: 100 F. Street, NE., Washington, DC. Date and Time of Previously Announced Meeting: September 15, 2010. Change In the Meeting: Room Change. The Joint...

42 CFR 412.72 - Modification of base-year costs.

Science.gov (United States)

2010-10-01

... 42 Public Health 2 2010-10-01 2010-10-01 false Modification of base-year costs. 412.72 Section 412... Modification of base-year costs. (a) Bases for modification of base-year costs. Base-year costs as determined... before November 16, 1983 has until November 15, 1983 to request its intermediary to reestimate its base...

Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer.

Science.gov (United States)

Hege, Kristen M; Bergsland, Emily K; Fisher, George A; Nemunaitis, John J; Warren, Robert S; McArthur, James G; Lin, Andy A; Schlom, Jeffrey; June, Carl H; Sherwin, Stephen A

2017-01-01

T cells engineered to express chimeric antigen receptors (CARs) have established efficacy in the treatment of B-cell malignancies, but their relevance in solid tumors remains undefined. Here we report results of the first human trials of CAR-T cells in the treatment of solid tumors performed in the 1990s. Patients with metastatic colorectal cancer (CRC) were treated in two phase 1 trials with first-generation retroviral transduced CAR-T cells targeting tumor-associated glycoprotein (TAG)-72 and including a CD3-zeta intracellular signaling domain (CART72 cells). In trial C-9701 and C-9702, CART72 cells were administered in escalating doses up to 10 10 total cells; in trial C-9701 CART72 cells were administered by intravenous infusion. In trial C-9702, CART72 cells were administered via direct hepatic artery infusion in patients with colorectal liver metastases. In both trials, a brief course of interferon-alpha (IFN-α) was given with each CART72 infusion to upregulate expression of TAG-72. Fourteen patients were enrolled in C-9701 and nine in C-9702. CART72 manufacturing success rate was 100% with an average transduction efficiency of 38%. Ten patients were treated in CC-9701 and 6 in CC-9702. Symptoms consistent with low-grade, cytokine release syndrome were observed in both trials without clear evidence of on target/off tumor toxicity. Detectable, but mostly short-term (≤14 weeks), persistence of CART72 cells was observed in blood; one patient had CART72 cells detectable at 48 weeks. Trafficking to tumor tissues was confirmed in a tumor biopsy from one of three patients. A subset of patients had 111 Indium-labeled CART72 cells injected, and trafficking could be detected to liver, but T cells appeared largely excluded from large metastatic deposits. Tumor biomarkers carcinoembryonic antigen (CEA) and TAG-72 were measured in serum; there was a precipitous decline of TAG-72, but not CEA, in some patients due to induction of an interfering antibody to the TAG-72

Evaluating meeting support tools

NARCIS (Netherlands)

Post, W.M.; Huis in't Veld, M.A.A.; Boogaard, S.A.A. van den

2008-01-01

Many attempts are underway for developing meeting support tools, but less attention is paid to the evaluation of meetingware. This article describes the development and testing of an instrument for evaluating meeting tools. First, we specified the object of evaluation - meetings - by means of a set

Evaluating meeting support tools

NARCIS (Netherlands)

Post, W.M.; Huis in 't Veld, M. M.A.; Boogaard, S.A.A. van den

2007-01-01

Many attempts are underway for developing meeting support tools, but less attention is paid to the evaluation of meetingware. This article describes the development and testing of an instrument for evaluating meeting tools. First, we specified the object of evaluation -meetings- by means of a set of

76 FR 54536 - Meeting

Science.gov (United States)

2011-09-01

... UNITED STATES INSTITUTE OF PEACE Meeting AGENCY: United States Institute of Peace. Date/Time... Peace Act, Public Law 98-525. Agenda: September 22, 2011 Board Meeting; Approval of Minutes of the One Hundred Fortieth Meeting (June 23-24, 2011) of the Board of Directors; Chairman's Report; President's...

Cytosolic calcium transients are a determinant of contraction-induced HSP72 transcription in single skeletal muscle fibers.

Science.gov (United States)

Stary, Creed M; Hogan, Michael C

2016-05-15

The intrinsic activating factors that induce transcription of heat shock protein 72 (HSP72) in skeletal muscle following exercise remain unclear. We hypothesized that the cytosolic Ca(2+) transient that occurs with depolarization is a determinant. We utilized intact, single skeletal muscle fibers from Xenopus laevis to test the role of the cytosolic Ca(2+) transient and several other exercise-related factors (fatigue, hypoxia, AMP kinase, and cross-bridge cycling) on the activation of HSP72 transcription. HSP72 and HSP60 mRNA levels were assessed with real-time quantitative PCR; cytosolic Ca(2+) concentration ([Ca(2+)]cyt) was assessed with fura-2. Both fatiguing and nonfatiguing contractions resulted in a significant increase in HSP72 mRNA. As expected, peak [Ca(2+)]cyt remained tightly coupled with peak developed tension in contracting fibers. Pretreatment with N-benzyl-p-toluene sulfonamide (BTS) resulted in depressed peak developed tension with stimulation, while peak [Ca(2+)]cyt remained largely unchanged from control values. Despite excitation-contraction uncoupling, BTS-treated fibers displayed a significant increase in HSP72 mRNA. Treatment of fibers with hypoxia (Po2: skeletal muscle depolarization provides a sufficient activating stimulus for HSP72 transcription. Metabolic or mechanical factors associated with fatigue development and cross-bridge cycling likely play a more limited role. Copyright © 2016 the American Physiological Society.

Bioinformatics Data Mining Approach Suggests Coexpression of AGTPBP1 with an ALS-linked Gene C9orf72

Directory of Open Access Journals (Sweden)

Shouta Kitano

2015-01-01

Full Text Available Background Expanded GGGGCC hexanucleotide repeats located in the noncoding region of the chromosome 9 open reading frame 72 ( C9orf72 gene represent the most common genetic abnormality for familial and sporadic amyotrophic lateral sclerosis (ALS and frontotemporal dementia (FTD. Formation of nuclear RNA foci, accumulation of repeat-associated non-ATG-translated dipeptide-repeat proteins, and haploinsufficiency of C9orf72 are proposed for pathological mechanisms of C9ALS/FTD. However, at present, the physiological function of C9orf72 remains largely unknown. Methods By searching on a bioinformatics database named COXPRESdb composed of the comprehensive gene coexpression data, we studied potential C9orf72 interactors. Results We identified the ATP/GTP binding protein 1 ( AGTPBP1 gene alternatively named NNA1 encoding a cytosolic carboxypeptidase whose mutation is causative of the degeneration of Purkinje cells and motor neurons as the most significant gene coexpressed with C9orf72. We verified coexpression and interaction of AGTPBP1 and C9orf72 in transfected cells by immunoprecipitation and in neurons of the human brain by double-labeling immunohistochemistry. Furthermore, we found a positive correlation between AGTPBP1 and C9orf72 mRNA expression levels in the set of 21 human brains examined. Conclusions These results suggest that AGTPBP1 serves as a C9orf72 interacting partner that plays a role in the regulation of neuronal function in a coordinated manner within the central nervous system.

77 FR 55837 - Board Meeting

Science.gov (United States)

2012-09-11

... FARM CREDIT SYSTEM INSURANCE CORPORATION Board Meeting AGENCY: Farm Credit System Insurance Corporation. ACTION: Regular meeting. SUMMARY: Notice is hereby given of the regular meeting of the Farm Credit System Insurance Corporation Board (Board). Date and Time: The meeting of the Board will be held...

Association between Ghrelin gene (GHRL polymorphisms and clinical response to atypical antipsychotic drugs in Han Chinese schizophrenia patients

Directory of Open Access Journals (Sweden)

Yang Yongfeng

2012-02-01

Full Text Available Abstract Background Ghrelin (GHRL is a pivotal peptide regulator of food intake, energy balance, and body mass. Weight gain (WG is a common side effect of the atypical antipsychotics (AAPs used to treat schizophrenia (SZ. Ghrelin polymorphisms have been associated with pathogenic variations in plasma lipid concentrations, blood pressure, plasma glucose, and body mass index (BMI. However, it is unclear whether GHRL polymorphisms are associated with WG due to AAPs. Furthermore, there is no evidence of an association between GHRL polymorphisms and SZ or the therapeutic response to AAPs. We explored these potential associations by genotyping GHRL alleles in SZ patients and controls. We also examined the relation between these SNPs and changes in metabolic indices during AAP treatment in SZ subgroups distinguished by high or low therapeutic response. Methods Four SNPs (Leu72Met, -501A/C, -604 G/A, and -1062 G > C were genotyped in 634 schizophrenia patients and 606 control subjects. Results There were no significant differences in allele frequencies, genotype distributions, or the distributions of two SNP haplotypes between SZ patients and healthy controls (P > 0.05. There was also no significant difference in symptom reduction between genotypes after 8 weeks of AAP treatment as measured by positive and negative symptom scale scores (PANSS. However, the -604 G/A polymorphism was associated with a greater BMI increase in response to AAP administration in both APP responders and non-responders as distinguished by PANSS score reduction (P P Conclusions These four GHRL gene SNPs were not associated with SZ in this Chinese Han population. The -604 G/A polymorphism was associated with significant BW and BMI increases during AAP treatment. Patients exhibiting higher WG showed greater improvements in positive and negative symptoms than patients exhibiting lower weight gain or weight loss.

Association between ghrelin gene (GHRL) polymorphisms and clinical response to atypical antipsychotic drugs in Han Chinese schizophrenia patients.

Science.gov (United States)

Yang, Yongfeng; Li, Wenqiang; Zhao, Jingyuan; Zhang, Hongxing; Song, Xueqin; Xiao, Bo; Yang, Ge; Jiang, Chengdi; Zhang, Dai; Yue, Weihua; Lv, Luxian

2012-02-28

Ghrelin (GHRL) is a pivotal peptide regulator of food intake, energy balance, and body mass. Weight gain (WG) is a common side effect of the atypical antipsychotics (AAPs) used to treat schizophrenia (SZ). Ghrelin polymorphisms have been associated with pathogenic variations in plasma lipid concentrations, blood pressure, plasma glucose, and body mass index (BMI). However, it is unclear whether GHRL polymorphisms are associated with WG due to AAPs. Furthermore, there is no evidence of an association between GHRL polymorphisms and SZ or the therapeutic response to AAPs. We explored these potential associations by genotyping GHRL alleles in SZ patients and controls. We also examined the relation between these SNPs and changes in metabolic indices during AAP treatment in SZ subgroups distinguished by high or low therapeutic response. Four SNPs (Leu72Met, -501A/C, -604 G/A, and -1062 G > C) were genotyped in 634 schizophrenia patients and 606 control subjects. There were no significant differences in allele frequencies, genotype distributions, or the distributions of two SNP haplotypes between SZ patients and healthy controls (P > 0.05). There was also no significant difference in symptom reduction between genotypes after 8 weeks of AAP treatment as measured by positive and negative symptom scale scores (PANSS). However, the -604 G/A polymorphism was associated with a greater BMI increase in response to AAP administration in both APP responders and non-responders as distinguished by PANSS score reduction (P GHRL gene SNPs were not associated with SZ in this Chinese Han population. The -604 G/A polymorphism was associated with significant BW and BMI increases during AAP treatment. Patients exhibiting higher WG showed greater improvements in positive and negative symptoms than patients exhibiting lower weight gain or weight loss.

5 CFR 1206.11 - Meeting place.

Science.gov (United States)

2010-01-01

... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Meeting place. 1206.11 Section 1206.11 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND PROCEDURES OPEN MEETINGS Conduct of Meetings § 1206.11 Meeting place. The Board will hold open meetings in meeting rooms designated in the...

78 FR 52997 - Connected Vehicle Research Program Public Meeting; Notice of Public Meeting

Science.gov (United States)

2013-08-27

... DEPARTMENT OF TRANSPORTATION Connected Vehicle Research Program Public Meeting; Notice of Public... overview of the ITS JPO Connected Vehicle research program. The meeting will take place September 24 to 26... . The public meeting is the best opportunity to learn details about the Connected Vehicle research...

Making Meetings Work Better.

Science.gov (United States)

Standke, Linda

1978-01-01

Focusing on the increased use by trainers of off-site facilities for employee training meetings, this article looks at some improvements and the expanding market in the meeting site industry. It also highlights emerging trends in the industry and covers the growth of meeting planning into a profession. (EM)

1990 Fall Meeting Report

Science.gov (United States)

Chapman, David S.

The AGU 1990 Fall Meeting, held in San Francisco December 3-7, continued the steady growth trend for the western meeting set over the last decade. About 5200 members registered for the meeting and 3836 papers were given. The scientific kickoff to the meeting was provided by a Union session on initial results of the current Magellan mission to Venus. The mission was also the focus of a public lecture and short film on highlights of the mission and an extensive Union poster session.

75 FR 76006 - Regular Meeting

Science.gov (United States)

2010-12-07

... FARM CREDIT SYSTEM INSURANCE CORPORATION Regular Meeting AGENCY: Farm Credit System Insurance Corporation Board. ACTION: Regular meeting. SUMMARY: Notice is hereby given of the regular meeting of the Farm Credit System Insurance Corporation Board (Board). Date and Time: The meeting of the Board will be held...

77 FR 2541 - Board Meeting

Science.gov (United States)

2012-01-18

... FARM CREDIT SYSTEM INSURANCE CORPORATION Board Meeting AGENCY: Farm Credit System Insurance Corporation Board; Regular Meeting. SUMMARY: Notice is hereby given of the regular meeting of the Farm Credit System Insurance Corporation Board (Board). DATE AND TIME: The meeting of the Board will be held at the...

76 FR 3629 - Regular Meeting

Science.gov (United States)

2011-01-20

... Meeting SUMMARY: Notice is hereby given of the regular meeting of the Farm Credit System Insurance Corporation Board (Board). Date and Time: The meeting of the Board will be held at the offices of the Farm... meeting of the Board will be open to the [[Page 3630

78 FR 73190 - Sunshine Act Meeting

Science.gov (United States)

2013-12-05

... FEDERAL RESERVE SYSTEM Sunshine Act Meeting Agency Holding the Meeting: Board of Governors of the...., Washington, DC 20551. STATUS: Open. On the day of the meeting, you will be able to view the meeting via... webcast of the meeting. A link to the meeting documentation will also be available approximately 20...

78 FR 46361 - Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting

Science.gov (United States)

2013-07-31

... stakeholders the opportunity to give policy, management, and technical input concerning Trinity River...-FF08EACT00] Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting... Trinity Management Council (TMC). DATES: Public meeting, Teleconference, and web-based meeting: TAMWG and...

78 FR 17226 - Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting

Science.gov (United States)

2013-03-20

... stakeholders the opportunity to give policy, management, and technical input concerning Trinity River...-FF08EACT00] Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting... Service, announce a public meeting, teleconference and web-based meeting of the Trinity Adaptive...

78 FR 49281 - Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting

Science.gov (United States)

2013-08-13

... opportunity to give policy, management, and technical input concerning Trinity River (California) restoration...-FF08EACT00] Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting... Service, announce a public meeting, teleconference, and web-based meeting of the Trinity Adaptive...

U.S. comments on co-chairmen WG.2/15, chapter 7-A assurance of supply

International Nuclear Information System (INIS)

1979-05-01

The U.S. delegation proposes revision in chapter 7 regarding assurance of supply, to reflect that alternative suppliers now exist to provide an assured supply, and that for most countries national enrichment facilities would not be practical or economic. The paper also argues that the spread of national facilities could increase proliferation risks. The revised text also argues that, because enrichment is highly capital-intensive, consumers should not expect significant surplus capacity at any given time, and should not interpret the absence of surplus capacity as an indication of lack of assurance in supply. Options which increase a consumer's flexibility in meeting enrichment needs are reviewed

Design and Evaluation of a Protection Relay for a Wind Generator Based on the Positive- and Negative-Sequence Fault Components

DEFF Research Database (Denmark)

Zheng, T. Y.; Cha, Seung-Tae; Crossley, P. A.

2013-01-01

To avoid undesirable disconnection of healthy wind generators (WGs) or a wind power plant, a WG protection relay should discriminate among faults, so that it can operate instantaneously for WG, connected feeder or connection bus faults, it can operate after a delay for inter-tie or grid faults......, and it can avoid operating for parallel WG or adjacent feeder faults. A WG protection relay based on the positive- and negativesequence fault components is proposed in the paper. At stage 1, the proposed relay uses the magnitude of the positive-sequence component in the fault current to distinguish faults...... at a parallel WG connected to the same feeder or at an adjacent feeder, from other faults at a connected feeder, an inter-tie, or a grid. At stage 2, the fault type is first determined using the relationships between the positive- and negative-sequence fault components. Then, the relay differentiates between...

75 FR 67393 - Notice of Public Meeting, Eastern Montana Resource Advisory Council Meeting

Science.gov (United States)

2010-11-02

... Public Meeting, Eastern Montana Resource Advisory Council Meeting AGENCY: Bureau of Land Management... 1972 (FACA), the U.S. Department of the Interior, Bureau of Land Management (BLM) Eastern Montana... Eastern Montana Resource Advisory Council will be held on Dec. 2, 2010 in Billings, Montana. The meeting...

75 FR 58350 - Meeting

Science.gov (United States)

2010-09-24

... UNITED STATES ARCTIC RESEARCH COMMISSION Meeting Notice is hereby given that the U.S. Arctic Research Commission will hold its 94th meeting in Fairbanks, AK, on October 6-8, 2010. The business session... approval of the agenda. (2) Approval of the minutes from the 93rd meeting. (3) Commissioners and staff...

Up-regulation of Hsp72 and keratin16 mediates wound healing in streptozotocin diabetic rats

Directory of Open Access Journals (Sweden)

Rasha R. Ahmed

2015-01-01

Full Text Available BACKGROUND: Impaired wound healing is a complication of diabetes and a serious problem in clinical practice. We previously found that whey protein (WP was able to regulate wound healing normally in streptozotocin (STZ-dia-betic models. This subsequent study was designed to assess the effect of WP on heat shock protein-72 (Hsp72 and keratin16 (Krt16 expression during wound healing in diabetic rats. METHODS: WP at a dosage of 100 mg/kg of body weight was orally administered daily to wounded normal and STZ-diabetic rats for 8 days. RESULTS: At day 4, the WP-treated diabetic wound was significantly reduced compared to that in the corresponding control. Diabetic wounded rats developed severe inflammatory infiltration and moderate capillary dilatation and regeneration. Treated rats had mild necrotic formation, moderate infiltration, moderate to severe capillary dilatation and regeneration, in addition to moderate epidermal formation. Hsp72 and Krt16 densities showed low and dense activity in diabetic wounded and diabetic wounded treated groups, respectively. At day 8, WP-treatment of diabetic wounded animals revealed great amelioration with complete recovery and closure of the wound. Reactivity of Hsp72 and Krt16 was reversed, showing dense and low, or medium and low, activity in the diabetic wounded and diabetic wounded treated groups, respectively. Hsp72 expression in the pancreas was found to show dense reactivity with WP-treated diabetic wound rats. CONCLUSION: This data provides evidence for the potential impact of WP in the up-regulation of Hsp72 and Krt16 in T1D, resulting in an improved wound healing process in diabetic models.

21 CFR 312.47 - Meetings.

Science.gov (United States)

2010-04-01

... resources permit. The general principle underlying the conduct of such meetings is that there should be free...) “End-of-Phase 2” meetings and meetings held before submission of a marketing application. At specific... meetings held near completion of Phase 3 and before submission of a marketing application (“pre-NDA...

41 CFR 105-72.301 - Standards for financial management systems.

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Standards for financial... Management § 105-72.301 Standards for financial management systems. (a) Federal awarding agencies shall... practical. (b) Recipients' financial management systems shall provide for the following. (1) Accurate...

Study of the proton-neutron interaction around $^{68}$Ni : Vibrational structure of $^{72,74}$Zn

CERN Multimedia

Hass, M; Blazhev, A A; Kruecken, R; Muecher, D; Kumar, V; Srebrny, J; Albers, M; Gernhaeuser, R A; Hadynska-klek, K; Eberth, J H; Lo bianco, G; Napiorkowski, P J; Bettermann, L; Das gupta, S; Kroell, T; Leske, J; Iwanicki, J S

We propose to study the $^{72}$Zn nucleus, 2 protons and 2 neutrons away from the possible double-magic $^{68}$Ni nucleus, by means of Coulomb Excitation in inverse kinematics. Current data suggest almost degenerated 2$^{+}$ states of 2-phonon and mixed-symmetric character, respectively. The identification of the 2$^+_{ms}$ state in $^{72}$Zn will be a direct measure of the interaction between valence protons and neutrons, which is the key to understand the nature of $^{68}$Ni. We furthermore propose to study the unusual behavior of the first excited 0$^{+}$ state in this region using the t($^{72}$Zn,p)$\\,^{74}$Zn reaction.

Structural and functional characterization of human apolipoprotein E 72-166 peptides in both aqueous and lipid environments

Directory of Open Access Journals (Sweden)

Chou Chi-Yuan

2011-01-01

Full Text Available Abstract Backgrounds There are three apolipoprotein E (apoE isoforms involved in human lipid homeostasis. In the present study, truncated apoE2-, apoE3- and apoE4-(72-166 peptides that are tailored to lack domain interactions are expressed and elucidated the structural and functional consequences. Methods & Results Circular dichroism analyses indicated that their secondary structure is still well organized. Analytical ultracentrifugation analyses demonstrated that apoE-(72-166 produces more complicated species in PBS. All three isoforms were significantly dissociated in the presence of dihexanoylphosphatidylcholine. Dimyristoylphosphatidylcholine turbidity clearance assay showed that apoE4-(72-166 maintains the highest lipid-binding capacity. Finally, only apoE4-(72-166 still maintained significant LDL receptor binding ability. Conclusions Overall, apoE4-(72-166 peptides displayed a higher lipid-binding and comparable receptor-binding ability as to full-length apoE. These findings provide the explanation of diverged functionality of truncated apoE isoforms.

9th Transgenic Technology Meeting (TT2010) in Berlin, Germany: a meeting report.

Science.gov (United States)

Saunders, Thomas L; Sobieszczuk, Peter

2010-12-01

The first Transgenic Technology (TT) Meeting was organized in 1999 by Johannes Wilbertz, Karolinska Institute, Stockholm, Sweden as a regional meeting. The TT Meetings continued in this way, constantly gathering additional practitioners of transgenic methodologies until the breakthrough in 2005 when the 6th TT Meeting in Barcelona, Spain, hosted by Lluis Montoliu (Centro Nacional de Biotecnologia, Madrid, Spain), generated the momentum to establish the International Society for Transgenic Technologies (ISTT). Since 2006, the ISTT has continued to promote the TT Meetings and provide its membership with a forum to discuss best practices and new methods in the field. The TT2010 Meeting was held at the Max Delbrück Center for Molecular Medicine (Berlin, Germany). Participation at the TT2010 Meeting exceeded the registration capacity and set a new attendance record. Session topics included methods for the generation of rat and mouse models of human disease, fundamental and advanced topics in rodent embryonic stem cells, and the newest transgenic technologies. Short presentations from selected abstracts were of especial interest. Roundtable discussions on transgenic facility establishment and cryoarchiving of mouse lines were favorably received. Students, technical staff, and professors participated in numerous discussions and came away with practical methods and new ideas for research.

Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients.

Science.gov (United States)

Prudencio, Mercedes; Gonzales, Patrick K; Cook, Casey N; Gendron, Tania F; Daughrity, Lillian M; Song, Yuping; Ebbert, Mark T W; van Blitterswijk, Marka; Zhang, Yong-Jie; Jansen-West, Karen; Baker, Matthew C; DeTure, Michael; Rademakers, Rosa; Boylan, Kevin B; Dickson, Dennis W; Petrucelli, Leonard; Link, Christopher D

2017-09-01

Significant transcriptome alterations are detected in the brain of patients with amyotrophic lateral sclerosis (ALS), including carriers of the C9orf72 repeat expansion and C9orf72-negative sporadic cases. Recently, the expression of repetitive element transcripts has been associated with toxicity and, while increased repetitive element expression has been observed in several neurodegenerative diseases, little is known about their contribution to ALS. To assess whether aberrant expression of repetitive element sequences are observed in ALS, we analysed RNA sequencing data from C9orf72-positive and sporadic ALS cases, as well as healthy controls. Transcripts from multiple classes and subclasses of repetitive elements (LINEs, endogenous retroviruses, DNA transposons, simple repeats, etc.) were significantly increased in the frontal cortex of C9orf72 ALS patients. A large collection of patient samples, representing both C9orf72 positive and negative ALS, ALS/FTLD, and FTLD cases, was used to validate the levels of several repetitive element transcripts. These analyses confirmed that repetitive element expression was significantly increased in C9orf72-positive compared to C9orf72-negative or control cases. While previous studies suggest an important link between TDP-43 and repetitive element biology, our data indicate that TDP-43 pathology alone is insufficient to account for the observed changes in repetitive elements in ALS/FTLD. Instead, we found that repetitive element expression positively correlated with RNA polymerase II activity in postmortem brain, and pharmacologic modulation of RNA polymerase II activity altered repetitive element expression in vitro. We conclude that increased RNA polymerase II activity in ALS/FTLD may lead to increased repetitive element transcript expression, a novel pathological feature of ALS/FTLD. © The Author 2017. Published by Oxford University Press.

41 CFR 301-72.1 - Why is common carrier presumed to be the most advantageous method of transportation?

Science.gov (United States)

2010-07-01

... presumed to be the most advantageous method of transportation? 301-72.1 Section 301-72.1 Public Contracts... Transportation § 301-72.1 Why is common carrier presumed to be the most advantageous method of transportation? Travel by common carrier is presumed to be the most advantageous method of transportation because it...

Bioinformatics Meets Virology: The European Virus Bioinformatics Center's Second Annual Meeting.

Science.gov (United States)

Ibrahim, Bashar; Arkhipova, Ksenia; Andeweg, Arno C; Posada-Céspedes, Susana; Enault, François; Gruber, Arthur; Koonin, Eugene V; Kupczok, Anne; Lemey, Philippe; McHardy, Alice C; McMahon, Dino P; Pickett, Brett E; Robertson, David L; Scheuermann, Richard H; Zhernakova, Alexandra; Zwart, Mark P; Schönhuth, Alexander; Dutilh, Bas E; Marz, Manja

2018-05-14

The Second Annual Meeting of the European Virus Bioinformatics Center (EVBC), held in Utrecht, Netherlands, focused on computational approaches in virology, with topics including (but not limited to) virus discovery, diagnostics, (meta-)genomics, modeling, epidemiology, molecular structure, evolution, and viral ecology. The goals of the Second Annual Meeting were threefold: (i) to bring together virologists and bioinformaticians from across the academic, industrial, professional, and training sectors to share best practice; (ii) to provide a meaningful and interactive scientific environment to promote discussion and collaboration between students, postdoctoral fellows, and both new and established investigators; (iii) to inspire and suggest new research directions and questions. Approximately 120 researchers from around the world attended the Second Annual Meeting of the EVBC this year, including 15 renowned international speakers. This report presents an overview of new developments and novel research findings that emerged during the meeting.

Deliberations of working group 2: trust and the institutional framework

International Nuclear Information System (INIS)

Metlay, D.

2000-01-01

The meeting of Working Group 2 (WG-2) was preceded by two presentations in the plenary session: 'Legal and Institutional Frameworks for Government Relations with Citizens' and 'The Role and Experience of Technical Oversight Bodies'. The first identified trust and legitimacy as key resources for effective policy making and democratic governance as well as the current progress and difficulties at OECD governments' level in promoting public trust and participation. The second described the use of technical oversight bodies to provide a function of mediation between scientists, public authorities and the general public, in order to facilitate communication and understanding of technical issues and research. Dr. Aebersold gave a presentation to WG-2 on the results of Switzerland's Expert Group on Disposal Concepts for Radioactive Waste (EKRA). This group was established to bridge between nuclear power plant operators and environmental organisations, who had opposing views of radioactive waste disposal in general, and the choice of the Wellenberg site for a geological repository in particular. The success of EKRA in having its recommendations accepted and advancing the long term waste management programme was attributed to, among other things: the popular acceptance of the EKRA chairman; the competence, independence and commitment of the EKRA members; the responsiveness of their recommendations to public concerns and social issues; and the openness and transparency of their work (including broad media coverage). Dr. Metlay, who chaired WG-2, described field studies that he has undertaken dealing with trust in specific institutions in the US. This initiated the discussions, which ranged from a general understanding of the nature of trust, to why it may be important in the successful siting and development of a repository. (author)

31 CFR 50.72 - Establishment of Federal Terrorism Policy Surcharge.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Establishment of Federal Terrorism... TERRORISM RISK INSURANCE PROGRAM Recoupment and Surcharge Procedures § 50.72 Establishment of Federal Terrorism Policy Surcharge. (a) Treasury will establish the Federal Terrorism Policy Surcharge based on the...

48 CFR 1552.209-72 - Organizational conflict of interest certification.

Science.gov (United States)

2010-10-01

... Provisions and Clauses 1552.209-72 Organizational conflict of interest certification. As prescribed in 1509... Conflict of Interest Certification (APR 1984) The offeror [] is [] is not aware of any information bearing on the existence of any potential organizational conflict of interest. If the offeror is aware of...

Public meeting

CERN Multimedia

HR Department

2010-01-01

Dear Colleagues, I am pleased to invite you to a public meeting which will be held on Thursday 11 November 2010 at 2:30 p.m., in the Main Auditorium (welcome coffee from 2 p.m.) In this meeting Sigurd Lettow, Director for Administration and General Infrastructure will present the Management’s proposals towards restoring full funding of the Pension Fund. The meeting will follow discussions which took place with the Staff Association, at the Standing Concertation Committee (CCP) of 1 November 2010 and will be held with the Members States, at the Tripartite Employment Conditions Forum (TREF) of 4 November 2010. You will be able to attend this presentation in the Main Auditorium or via the webcast. The Management will also be available to reply to your questions on this subject. Best regards, Anne-Sylvie Catherin

The art of leading meetings.

Science.gov (United States)

English, C B

1987-05-01

The ability to skillfully lead meetings can contribute to a manager's effectiveness. There are four types of meetings, each serving different needs and requiring different leadership. A manager must know when to hold meetings, what leadership style is appropriate, how and when to use participative management, and how to facilitate a consensus. Considerable planning must be done before a meeting is held. Various leadership and communication skills are required to effectively open, conduct, and close a meeting. Finally, the leader needs to know how to deal with participants who become problems.

Competitive accumulation of betaines by Escherichia coli K-12 and derivative strains lacking betaine porters.

Science.gov (United States)

Randall, K; Lever, M; Peddie, B A; Chambers, S T

1995-08-17

Escherichia coli was grown in hyperosmotic media containing both glycine betaine and one other betaine. E. coli K-12 derivative WG439 (putP- proP- proU-) did not accumulate any of 15 betaines. Strains WG445 (putP- proP- proU+), WG443 (putP- proP+ proU-) and the control strains all accumulated less betaine, (CH3)3N(+)-(CH2)n-COO-, when n was greater than 1. Accumulation was not detectable when n = 5. Both L- and D-isomers of alpha-substituted betaines were accumulated by both strains WG443 and WG445, the D-isomers more slowly. Hydroxylated alpha-substituted betaines were accumulated relatively more through the osmoregulated transport protein ProU than through ProP. In actively growing cultures glycine betaine appeared to be the preferred substrate for accumulation, but the proportion of the second accumulated betaine increased as cultures approached stationary phase.

Solar Electromagnetic Radiation Study for Solar Cycle 22: Solar Ultraviolet Irradiance, 120 to 300 NM: Report of Working Groups 2 and 3 of SOLERS 22

Science.gov (United States)

Rottman, G. J.; Cebula, R. P.; Gillotay, D.; Simon, P. A.

1996-01-01

This report summarizes the activities of Working Group 2 and Working Group 3 of the SOLax Electromagnetic Radiation Study for Solar Cycle 22 (SOLERS22) Program. The international (SOLERS22) is Project 1.2 of the Solar-Terrestrial Energy Program (STEP) sponsored by SCOSTEP, a committee of the International Council of Scientific Unions). SOLERS22 is comprised of five Working Groups, each concentrating on a specific wave-length range: WG-1 - visible and infrared, WG-2 - mid-ultraviolet (200 < A < 300 nm), WG-3 - Far-ultraviolet (lambda greater than 100 and lambda less than 200 nanometers), WG-4 - extreme-ultraviolet (lambda greater than 10 and lambda less than 100 nm), and WG-5 - X-ray (lambda greater than 1 and lambda less than 10 nano meters). The overarching goals of SOLERS22 are to: 1) establish daily solar irradiance values in the specified wavelength ranges, 2) consider the evolving solar structures as the cause of temporal variations, and 3) understand the underlying physical processes driving these changes.

Public meetings

CERN Multimedia

Staff Association

2017-01-01

Do you have questions about the elections to the Staff Council, 2017 MERIT exercise, EVE and School, LD to IC exercise, CHIS, the Pension Fund… Come get informed and ask your questions at our public meetings. These public meetings are also an opportunity to get the more information on current issues. Benefit from this occasion to get the latest news and to discuss with the representatives of the statutory body that is the Staff Association!

36 CFR 1260.72 - Can previously released White House originated information be reclassified or have its...

Science.gov (United States)

2010-07-01

... House originated information be reclassified or have its classification restored? 1260.72 Section 1260... DECLASSIFICATION OF NATIONAL SECURITY INFORMATION Reclassification § 1260.72 Can previously released White House... close, review, and possibly reclassify or restore the classification of White House originated...

A Case of Simultaneous, Biopsy-Proven, Classic, ANCA-Positive Wegener's Granulomatosis and Anti-GBM Disease, but without Detectible Circulating Anti-GBM Antibodies

OpenAIRE

Gmurczyk, Aleksandra; Ahya, Shubhada N.; Goldschmidt, Robert; Kim, George; Ho, L. Tammy; Nash, Kevin

2010-01-01

Wegener's granulomatosis (WG) is a systemic, necrotizing, granulomatous vasculitis of unknown etiology. Approximately 75% of cases present as classic WG with both pulmonary and renal involvement, while the remaining 25% of patients present with a limited form with either predominantly upper or lower respiratory tract symptoms. Ninety percent of WG patients have circulating anti–neutrophil cytoplasmic antibodies (ANCA), and approximately 10% have both circulating ANCA antibodies and concomitan...

Present status of JENDL-3.3

International Nuclear Information System (INIS)

Nakagawa, Tsuneo; Shibata, Keiichi

2001-01-01

The latest version of JENDL General Purpose Library, JENDL-3.3, is being compiled. The evaluations for JENDL-3.3 have been performed mainly by the Medium-Heavy Nuclide Data Evaluation WG, the Heavy Nuclide Data Evaluation WG and the Delayed Neutron WG in the Japanese Nuclear Data Committee. The main objective of the evaluations is to solve the problems that were pointed out in JENDL-3.2. (author)

Background paper on aquaculture research

OpenAIRE

Wenblad, Axel; Jokumsen, Alfred; Eskelinen, Unto; Torrissen, Ole

2013-01-01

The Board of MISTRA established in 2012 a Working Group (WG) on Aquaculture to provide the Board with background information for its upcoming decision on whether the foundation should invest in aquaculture research. The WG included Senior Advisor Axel Wenblad, Sweden (Chairman), Professor Ole Torrissen, Norway, Senior Advisory Scientist Unto Eskelinen, Finland and Senior Advisory Scientist Alfred Jokumsen, Denmark. The WG performed an investigation of the Swedish aquaculture sector including ...