WorldWideScience

Sample records for meeting combined analysis

  1. Planning meeting combined analysis, North America residential radon studies

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-10-01

    This report describes the Third International Department of Energy/ Commission of European Communities Workshop on Residential Radon Epidemiology held in February 1995 in Baltimore, MD. This culminates a major effort begun 1988, co-sponsored by the DOE and the CEC Radiation Protection Programme to identify and bring together all those scientists worldwide performing epidemiological case control studies of residential radon and lung cancer. Two prior meetings were held in 1989 and 1991. The goal of this effort is to work with the investigators and to pool these studies to increase their limited statistical power and to maximize any information that could be gained from them. That goal has now been met. At this Workshop the task moved from planning and agreement to implementation, as many of the studies were finally being completed and published. This report provides a summary of the Workshop as well as that of the first implementation workgroup meeting hosted by Health Canada. Selected papers have been indexed separately for inclusion in the Energy Science and Technology Database.

  2. Combined modalities: chemotherapy/radiotherapy. Meeting summary

    International Nuclear Information System (INIS)

    Phillips, T.L.

    1979-01-01

    The effects of combined modalities, the standardization of terminology, the mechanisms of chemotherapeutic interactions with radiation and responses of normal and tumor systems are summarized from information presented at the Conference on Combined Modalities

  3. ANNUAL BALI INTERNATIONAL COMBINED CLINICAL MEETING

    Directory of Open Access Journals (Sweden)

    John Svigos

    2015-08-01

    Full Text Available Background: This valuable collaboration between Adelaide and Bali was first convened by Prof. I G. Surya, the late Prof. Made Kornia and Associate Prof. John Svigos in May 2011 at Sanglah General Hospital, Bali-Indonesia. This is a three day clinical meeting consisting of a daily Plenary Session for formal presentations running along with a Concurrent Session predominantly for “hands on” and interactive teaching. The meeting has a multidisciplinary focus which is in tune with contemporary Maternal Fetal Medicine practice and consists of obstetricians, midwives, neonatologists and obstetric anaesthetists from both cities sharing their respective experiences. From an initial modest meeting with 80 registrants this has now grown to over 300 registrants in 2015. A fourth day was trialed in 2014 in which a Field Day was incorporated into the program and enabled the overseas participants to gain some first hand experience in the workings of an orphanage (Anak Anak Bali Kids, a midwife obstetric unit (Bumi Sehat and a level two hospital (Sanjiwani Hospital, Gianyar. Further Field Days are anticipated at future meetings. The Visiting Faculty from Australia are predominantly from the Women’s and Children’s Hospital with input from The Lyell McEwin Hospital both in Adelaide, The Royal North Shore Hospital and the Royal Prince Alfred Hospital in Sydney and the King Edward Memorial Hospital in Perth. The broader strategic aspects of the collaboration have seen the rotation of three MFM Trainees from the Trigonum (Denpasar, Surabaya and Malang through Adelaide for two months in 2011 and 2012 as part of their MFM training. Unfortunately AusAID funding has not been forthcoming for further rotations to occur but in 2016 a multidisciplinary group from Sanglah General Hospital will be making a one week visit to the Women’s and Children’s Hospital as a forerunner to further visits. Meantime the collaborations with the Dr. Soetomo Hospital, Surabaya and

  4. ITER technical meeting on nuclear analysis

    International Nuclear Information System (INIS)

    Khripunov, V.

    2000-01-01

    The ITER technical meeting on nuclear analysis was organized on 24-25 February 2000 at the ITER Joint Work Site in Garching. It was clear from the meeting that continuous nuclear analysis is a fundamental part of the design process

  5. Automatic analysis of multiparty meetings

    Indian Academy of Sciences (India)

    of the analyses carried out by hand is still well beyond what can be done ... meeting communication, it follows that multiple, asynchronous streams of .... enabled us to develop system-level evaluations (discussed further in section 4), at the cost of less ..... Stasser G, Taylor L 1991 Speaking turns in face-to-face discussions, ...

  6. 40 CFR 141.551 - What strengthened combined filter effluent turbidity limits must my system meet?

    Science.gov (United States)

    2010-07-01

    ... effluent turbidity limits must my system meet? 141.551 Section 141.551 Protection of Environment... Effluent Requirements § 141.551 What strengthened combined filter effluent turbidity limits must my system meet? Your system must meet two strengthened combined filter effluent turbidity limits. (a) The first...

  7. Combining triggers in HEP data analysis

    International Nuclear Information System (INIS)

    Lendermann, Victor; Herbst, Michael; Krueger, Katja; Schultz-Coulon, Hans-Christian; Stamen, Rainer; Haller, Johannes

    2009-01-01

    Modern high-energy physics experiments collect data using dedicated complex multi-level trigger systems which perform an online selection of potentially interesting events. In general, this selection suffers from inefficiencies. A further loss of statistics occurs when the rate of accepted events is artificially scaled down in order to meet bandwidth constraints. An offline analysis of the recorded data must correct for the resulting losses in order to determine the original statistics of the analysed data sample. This is particularly challenging when data samples recorded by several triggers are combined. In this paper we present methods for the calculation of the offline corrections and study their statistical performance. Implications on building and operating trigger systems are discussed. (orig.)

  8. Combining triggers in HEP data analysis

    Energy Technology Data Exchange (ETDEWEB)

    Lendermann, Victor; Herbst, Michael; Krueger, Katja; Schultz-Coulon, Hans-Christian; Stamen, Rainer [Heidelberg Univ. (Germany). Kirchhoff-Institut fuer Physik; Haller, Johannes [Hamburg Univ. (Germany). Institut fuer Experimentalphysik

    2009-01-15

    Modern high-energy physics experiments collect data using dedicated complex multi-level trigger systems which perform an online selection of potentially interesting events. In general, this selection suffers from inefficiencies. A further loss of statistics occurs when the rate of accepted events is artificially scaled down in order to meet bandwidth constraints. An offline analysis of the recorded data must correct for the resulting losses in order to determine the original statistics of the analysed data sample. This is particularly challenging when data samples recorded by several triggers are combined. In this paper we present methods for the calculation of the offline corrections and study their statistical performance. Implications on building and operating trigger systems are discussed. (orig.)

  9. Proceedings of the third meeting on nuclear analysis

    International Nuclear Information System (INIS)

    1984-04-01

    This international meeting presents a series of methodical and device developments in the field of nuclear analysis techniques such as nuclear reaction analysis, activation analysis, pixe analysis, tracer techniques or atom and nuclear spectroscopy. The applications cover an extensive field in energetics, geology, medicine, biology, environment protection, materials science etc. and are presented in 141 papers

  10. Computer science: Data analysis meets quantum physics

    Science.gov (United States)

    Schramm, Steven

    2017-10-01

    A technique that combines machine learning and quantum computing has been used to identify the particles known as Higgs bosons. The method could find applications in many areas of science. See Letter p.375

  11. Activation Analysis. Proceedings of an Informal Study Group Meeting

    International Nuclear Information System (INIS)

    1971-01-01

    As part of its programme to promote the exchange of information relating to nuclear science and technology, the International Atomic Energy Agency convened in Bangkok, Thailand, from 6-8 July 1970, an informal meeting to discuss the topic of Activation Analysis. The meeting was attended by participants drawn from the following countries: Australia, Burma, Ceylon, Republic of China, India, Indonesia, Prance, Japan, Republic of Korea, New Zealand, Philippines, Singapore, Thailand, United States of America and Vietnam. The proceedings consist of the contributions presented at the meeting with minor editorial changes

  12. Activation Analysis. Proceedings of an Informal Study Group Meeting

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1971-07-01

    As part of its programme to promote the exchange of information relating to nuclear science and technology, the International Atomic Energy Agency convened in Bangkok, Thailand, from 6-8 July 1970, an informal meeting to discuss the topic of Activation Analysis. The meeting was attended by participants drawn from the following countries: Australia, Burma, Ceylon, Republic of China, India, Indonesia, Prance, Japan, Republic of Korea, New Zealand, Philippines, Singapore, Thailand, United States of America and Vietnam. The proceedings consist of the contributions presented at the meeting with minor editorial changes.

  13. Integrated Data Collection Analysis (IDCA) Program — Quarterly Review Meeting

    Energy Technology Data Exchange (ETDEWEB)

    Sandstrom, Mary M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Brown, Geoffrey W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Warner, Kirstin F. [Naval Surface Warfare Center (IHD-NSWC), Indian Head, MD (United States). Indian Head Division; Sorensen, Daniel N. [Naval Surface Warfare Center (IHD-NSWC), Indian Head, MD (United States). Indian Head Division; Remmers, Daniel L. [Naval Surface Warfare Center (IHD-NSWC), Indian Head, MD (United States). Indian Head Division; Shelley, Timothy J. [Air Force Research Lab. (AFRL/RXQF), Tyndall AFB, FL (United States); Reyes, Jose A. [Applied Research Associates, Inc., Tyndall AFB, FL (United States); Phillips, Jason J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hsu, Peter C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Reynolds, John G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2011-12-05

    On November 9 and 10, 2011 the IDCA had the annual quarterly meeting. The meeting started the afternoon of the first day with a tour of the NSWC IHD explosives safety testing and analysis facilities. The meeting on the second day addressed the formal sponsor review and further technical issues for the IDCA. Examination of the IHD equipment during the tour, lead to a long discussion on liquid test methods. The discussion resulted in revision of liquid test methods in the impact test and selection of a new liquid test standard. In addition, modifications to friction, spark and thermal test methods were discussed.

  14. Ratio Analysis: Where Investments Meet Mathematics.

    Science.gov (United States)

    Barton, Susan D.; Woodbury, Denise

    2002-01-01

    Discusses ratio analysis by which investments may be evaluated. Requires the use of fundamental mathematics, problem solving, and a comparison of the mathematical results within the framework of industry. (Author/NB)

  15. Good analytical practice in the analysis of IAEA materials for certification. Report of a consultants' meeting

    International Nuclear Information System (INIS)

    1999-01-01

    The purpose of this Consultant's Meeting report was to provide basic guidelines to the analysts involved in IAEA certification analysis for IAEA-392 and IAEA-393 Algae Reference Materials and to harmonise the analytical approach. The experience of this exercise will be combined with the requirements of ISO Guide 34 and 35 and should be the basis for a planned guide book on this topic. The Meeting was focused on on the practical implementation of the quality requirements for Reference Material analysis and certification procedures from ISO Guide 34 and ISO Guide 35

  16. Energy Analysis in Combined Reforming of Propane

    Directory of Open Access Journals (Sweden)

    K. Moon

    2013-01-01

    Full Text Available Combined (steam and CO2 reforming is one of the methods to produce syngas for different applications. An energy requirement analysis of steam reforming to dry reforming with intermediate steps of steam reduction and equivalent CO2 addition to the feed fuel for syngas generation has been done to identify condition for optimum process operation. Thermodynamic equilibrium data for combined reforming was generated for temperature range of 400–1000°C at 1 bar pressure and combined oxidant (CO2 + H2O stream to propane (fuel ratio of 3, 6, and 9 by employing the Gibbs free energy minimization algorithm of HSC Chemistry software 5.1. Total energy requirement including preheating and reaction enthalpy calculations were done using the equilibrium product composition. Carbon and methane formation was significantly reduced in combined reforming than pure dry reforming, while the energy requirements were lower than pure steam reforming. Temperatures of minimum energy requirement were found in the data analysis of combined reforming which were optimum for the process.

  17. First Meeting in Topology and Functional Analysis

    CERN Document Server

    López-Pellicer, Manuel

    2014-01-01

    Descriptive topology and functional analysis, with extensive material demonstrating new connections between them, are the subject of the first section of this work. Applications to spaces of continuous functions, topological Abelian groups, linear topological equivalence and to the separable quotient problem are included and are presented as open problems. The second section is devoted to Banach spaces, Banach algebras and operator theory. Each chapter presents a lot of worthwhile and important recent theorems with an abstract discussing the material in the chapter. Each chapter can almost be seen as a survey covering a particular area.

  18. PHARMACOECONOMIC ANALYSIS OF ANTIHYPERTENSIVE DRUG COMBINATIONS USE

    Directory of Open Access Journals (Sweden)

    E. I. Tarlovskaya

    2015-09-01

    Full Text Available Aim. To pursue pharmacoeconomic analysis of two drug combinations of ACE inhibitor (enalapril and diuretic.Material and methods. Patients with arterial hypertension degree 2 and diabetes mellitus type 2 without ischemic heart disease (n=56 were included into the study. Blood pressure (BP dynamics and cost/effectiveness ratio were evaluated.Results. In group A (fixed combination of original enalapril/hydrochlorothiazide 61% of patients achieved target BP level with initial dose, and the rest 39% of patients – with double dose. In group B (non-fixed combination of generic enalapril/indapamide 60% of patients achieved the target BP with initial dose of drugs, 33% - with double dose of ACE inhibitor, and 7% - with additional amlodipine administration. In patients of group A systolic BP (SBP reduction was 45.82±1.23 mm Hg by the 12th week vs. 40.0±0.81 mm Hg in patients of group B; diastolic BP (DBP reduction was 22.47±1.05 mm Hg and 18.76±0.70 mm Hg, respectively, by the 12th week of treatment. In the first month of treatment costs of target BP achievement was 298.62 rubles per patient in group A, and 299.50 rubles – in group B; by the 12th week of treatment – 629.45 and 631.22 rubles, respectively. Costs of SBP and DBP reduction by 1 mm Hg during 12 weeks of therapy were 13 and 27 rubles per patient, respectively, in group A, and 16 and 34 rubles per patient, respectively, in group B.Conclusion. The original fixed combination (enalapril+hydrochlorothiazide proved to be more clinically effective and more cost effective in the treatment of hypertensive patients in comparison with the non-fixed combination of generic drugs (enalapril+indapamide.

  19. 40 CFR 141.550 - Is my system required to meet subpart T combined filter effluent turbidity limits?

    Science.gov (United States)

    2010-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Filtration and Disinfection-Systems Serving Fewer Than 10,000 People Combined Filter... utilize filtration other than slow sand filtration or diatomaceous earth filtration must meet the combined...

  20. Meeting

    Indian Academy of Sciences (India)

    July 1989 No.19 Newsletter of the Indian Academy of Sciences. 55th Annual. Meeting ... in the world, keeping alive atthe same time his research interests, abreast .... theory made a comeback with many new ideas and with the success of the ...

  1. Combining Conversation Analysis and Nexus Analysis to explore hospital practices

    DEFF Research Database (Denmark)

    Paasch, Bettina Sletten

    , ethnographic observations, interviews, photos and documents were obtained. Inspired by the analytical manoeuvre of zooming in and zooming out proposed by Nicolini (Nicolini, 2009; Nicolini, 2013) the present study uses Conversations Analysis (Sacks, Schegloff, & Jefferson, 1974) and Embodied Interaction...... of interaction. In the conducted interviews nurses report mobile work phones to disturb interactions with patients when they ring, however, analysing the recorded interactions with tools from Conversations Analysis and Embodied Interaction Analysis displays how nurses demonstrate sophisticated awareness...... interrelationships influencing it. The present study thus showcases how Conversation Analysis and Nexus Analysis can be combined to achieve a multi-layered perspective on interactions between nurses, patients and mobile work phones....

  2. Combination processes for food irradiation. Proceedings of the final research co-ordination meeting

    International Nuclear Information System (INIS)

    1998-01-01

    There is an increasing consumer demand for food that is safe, minimally processed, visually attractive, full flavoured, nutritious, and convenient to prepare and serve, that has fewer preservatives, and that is available throughout the year at an affordable cost. Consumer concern and regulatory restrictions on the use of preservatives and pesticides in food are adversely affecting international trade in many food products. As a result, minimally processed, chilled foods and ready to eat foods are increasingly being marketed to satisfy consumer demand in both developed and developing countries. However, such foods could introduce new microbiological risks to the population, especially to those who are immunocompromised or generally at risk (children, pregnant women, the elderly, etc.). In view of these factors, a 5 year Co-ordinated Research Programme (CRP) on Irradiation in Combination with Other Processes for Improving Food Quality was initiated in 1991 by the Food and Agriculture Organization of the United Nations and the International Atomic Energy Agency through their Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture. The objectives of this CRP were to evaluate: 1) Combination treatment involving irradiation in order to extend the self-life of meat, seafood, fruits and vegetables at refrigeration temperatures and under ambient conditions; 2) Combination treatment involving irradiation in order to ensure the microbiological safety of foods, both individual and composite, including prepared meals; 3) Shelf-life extension of chilled, prepared meals and the development of shelf stable food and food components through combination treatment involving irradiation; 4) Energy requirements of combination processes involving irradiation in comparison to other food processes. Scientists from 14 countries participated in the CRP by carrying out the work under Research Contracts and Agreements with the Joint FAO/IAEA Division. The first Research Co

  3. Combined heat and power's potential to meet New York City's sustainability goals

    International Nuclear Information System (INIS)

    Howard, Bianca; Saba, Alexis; Gerrard, Michael; Modi, Vijay

    2014-01-01

    Combined Heat and Power (CHP) has been proven as a mature technology that can benefit both building owners and utility operators. As the economic and environmental benefits of CHP in urban centers gain recognition, regulations and policies have evolved to encourage their deployment. However, the question remains whether these policies are sufficient in helping to achieve the larger sustainability goals, such as the New York City-specific goal of incorporating 800 MW of distributed generation. In this paper, the current regulatory and policy environment for CHP is discussed. Then, an engineering analysis estimating the potential for CHP in NYC at the individual building and microgrid scale, considered a city block, is performed. This analysis indicates that over 800 MW of individual building CHP systems would qualify for the current incentives but many systems would need to undergo more cumbersome air permitting processes reducing the viable capacity to 360 MW. In addition microgrid CHP systems with multiple owners could contribute to meeting the goal even after considering air permits; however, these systems may incorporate many residential customers. The regulatory framework for microgrids with multiple owners and especially residential customers is particularly uncertain therefore additional policies would be needed to facilitate their development. - Highlights: • Estimates 1580 MW and 3042 MW CHP capacity at the building and microgrid scales. • Citywide emissions could reduce 4% at the building and 9% at the microgrid scale. • CHP microgrid systems operate at similar efficiencies while providing energy to buildings not viable for CHP. • Current regulatory and policy mechanisms would affect at least 800 MW of CHP systems. • Microgrid CHP systems may be necessary to the City's meet distributed generation goals

  4. Proposed combination of training and education to meet the bachelor of science requirements

    International Nuclear Information System (INIS)

    Wilson, A.E.

    1987-01-01

    The basic similarities and differences of the education and training which, in the author's opinion, are actually needed by reactor operators are outlined and compared with the NRC requirements. Examples of engineering degree programs are presented to demonstrate that they are NOT the appropriate educational goal for a senior reactor operator. A possible program of study which could be implemented jointly by a utility and a nearby college or university is presented. The program combines both education and training to complete the requirements for a bachelors degree. Those student-operators entering the program should be able to work as auxiliary operators while pursuing the degree part time and qualify for the NRC Reactor Operator exam in five years. Then, while working as RO's, they should complete the degree requirements in another year. After an additional year of RO experience, they should meet the NRC requirements for Senior Operator. Finally, some of the possible pitfalls of such a program are discussed. These include such things as drop-outs, union agreements, inflexibility of educational institutions and, of course, cost

  5. Reliability analysis of RC containment structures under combined loads

    International Nuclear Information System (INIS)

    Hwang, H.; Reich, M.; Kagami, S.

    1984-01-01

    This paper discusses a reliability analysis method and load combination design criteria for reinforced concrete containment structures under combined loads. The probability based reliability analysis method is briefly described. For load combination design criteria, derivations of the load factors for accidental pressure due to a design basis accident and safe shutdown earthquake (SSE) for three target limit state probabilities are presented

  6. Operator Semigroups meet Complex Analysis, Harmonic Analysis and Mathematical Physics

    CERN Document Server

    Chill, Ralph; Tomilov, Yuri

    2015-01-01

    This proceedings volume originates from a conference held in Herrnhut in June 2013. It provides unique insights into the power of abstract methods and techniques in dealing successfully with numerous applications stemming from classical analysis and mathematical physics. The book features diverse topics in the area of operator semigroups, including partial differential equations, martingale and Hilbert transforms, Banach and von Neumann algebras, Schrödinger operators, maximal regularity and Fourier multipliers, interpolation, operator-theoretical problems (concerning generation, perturbation and dilation, for example), and various qualitative and quantitative Tauberian theorems with a focus on transfinite induction and magics of Cantor. The last fifteen years have seen the dawn of a new era for semigroup theory with the emphasis on applications of abstract results, often unexpected and far removed from traditional ones. The aim of the conference was to bring together prominent experts in the field of modern...

  7. 76 FR 20717 - NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting

    Science.gov (United States)

    2011-04-13

    ... amended, the National Aeronautics and Space Administration announces a meeting of the Audit, Finance and... Center), and must state that they are attending the Audit, Finance, and Analysis Committee meeting in...

  8. 78 FR 59648 - Bureau of Economic Analysis Advisory Committee Meeting

    Science.gov (United States)

    2013-09-27

    ... new and rapidly growing economic activities arising from innovative and advancing technologies, and... meeting is open to the public. Because of security procedures, anyone planning to attend the meeting must...

  9. Buckling analysis for anisotropic laminated plates under combined inplane loads

    Science.gov (United States)

    Viswanathan, A. V.; Tamekuni, M.; Baker, L. L.

    1974-01-01

    The buckling analysis presented considers rectangular flat or curved general laminates subjected to combined inplane normal and shear loads. Linear theory is used in the analysis. All prebuckling deformations and any initial imperfections are ignored. The analysis method can be readily extended to longitudinally stiffened structures subjected to combined inplane normal and shear loads.

  10. Combining risk analysis and operating experience

    International Nuclear Information System (INIS)

    1986-10-01

    In recent years there has been an increasing interest in the systematic utilization of operating experience in the decision making process concerning large industrial facilities. Even before the advent of Probabilistic Safety Assessment (PSA), operating experience had always played an important role in such decisions. Of course, operating experience has always been an input to PSA also; however, as PSA becomes more mature and the quality and quantity of operating experience improve, greater emphasis is now being placed on the use of operating experience to update and validate PSA and thereby provide a more rational basis for decision making. This report outlines the ways in which data are collected, processed using mathematical techniques and utilized in decision making. It is not intended to provide details of the methods and procedures to be used in these areas, but is rather intended as an introduction to these topics and some of the relevant literature. The meeting presentations were divided into three sessions devoted to the following topics: evaluation of nuclear power plants operational experience (5 papers); uncertainties (2 papers); probabilistic safety assessment studies in Member States (7 papers). A separate abstract was prepared for each of these papers

  11. Setup Analysis: Combining SMED with Other Tools

    Directory of Open Access Journals (Sweden)

    Stadnicka Dorota

    2015-02-01

    Full Text Available The purpose of this paper is to propose the methodology for the setup analysis, which can be implemented mainly in small and medium enterprises which are not convinced to implement the setups development. The methodology was developed after the research which determined the problem. Companies still have difficulties with a long setup time. Many of them do nothing to decrease this time. A long setup is not a sufficient reason for companies to undertake any actions towards the setup time reduction. To encourage companies to implement SMED it is essential to make some analyses of changeovers in order to discover problems. The methodology proposed can really encourage the management to take a decision about the SMED implementation, and that was verified in a production company. The setup analysis methodology is made up of seven steps. Four of them concern a setups analysis in a chosen area of a company, such as a work stand which is a bottleneck with many setups. The goal is to convince the management to begin actions concerning the setups improvement. The last three steps are related to a certain setup and, there, the goal is to reduce a setup time and the risk of problems which can appear during the setup. In this paper, the tools such as SMED, Pareto analysis, statistical analysis, FMEA and other were used.

  12. Association analysis of multiple traits by an approach of combining ...

    Indian Academy of Sciences (India)

    Lili Chen

    diseases. Joint analysis of multiple traits can increase statistical power of association analysis and uncover the underlying genetic ... genthaler and Thilly 2007), the combined multivariate and ... Because of using reverse regression model, our.

  13. Generalized fault tree analysis combined with state analysis

    International Nuclear Information System (INIS)

    Caldarola, L.

    1980-02-01

    An analytical theory has been developed which allows one to calculate the occurrence probability of the top event of a fault tree with multistate (two or more than two states) components. It is shown that, in order to correctly describe a system with multistate components, a special type of boolean algebra is required. This is called 'boolean algebra with restrictions on variables' and its basic rules are the same as those of the traditional boolean algebra with some additional restrictions on the variables. These restrictions are extensively discussed in the paper. It is also shown that the boolean algebra with restrictions on variables facilitates the task of formally combining fault tree analysis with state analysis. The computer program MUSTAFA 1 based on the above theory has been developed. It can analyse fault trees of system containing statistically independent as well as dependent components with two or more than two states. MUSTAFA 1 can handle coherent as well as non coherent boolean functions. (orig.) 891 HP/orig. 892 MB [de

  14. Combination and Integration of Qualitative and Quantitative Analysis

    Directory of Open Access Journals (Sweden)

    Philipp Mayring

    2001-02-01

    Full Text Available In this paper, I am going to outline ways of combining qualitative and quantitative steps of analysis on five levels. On the technical level, programs for the computer-aided analysis of qualitative data offer various combinations. Where the data are concerned, the employment of categories (for instance by using qualitative content analysis allows for combining qualitative and quantitative forms of data analysis. On the individual level, the creation of types and the inductive generalisation of cases allow for proceeding from individual case material to quantitative generalisations. As for research design, different models can be distinguished (preliminary study, generalisation, elaboration, triangulation which combine qualitative and quantitative steps of analysis. Where the logic of research is concerned, it can be shown that an extended process model which combined qualitative and quantitative research can be appropriate and thus lead to an integration of the two approaches. URN: urn:nbn:de:0114-fqs010162

  15. Image analysis and microscopy: a useful combination

    Directory of Open Access Journals (Sweden)

    Pinotti L.

    2009-01-01

    Full Text Available The TSE Roadmap published in 2005 (DG for Health and Consumer Protection, 2005 suggests that short and medium term (2005-2009 amendments to control BSE policy should include “a relaxation of certain measures of the current total feed ban when certain conditions are met”. The same document noted “the starting point when revising the current feed ban provisions should be risk-based but at the same time taking into account the control tools in place to evaluate and ensure the proper implementation of this feed ban”. The clear implication is that adequate analytical methods to detect constituents of animal origin in feedstuffs are required. The official analytical method for the detection of constituents of animal origin in feedstuffs is the microscopic examination technique as described in Commission Directive 2003/126/EC of 23 December 2003 [OJ L 339, 24.12.2003, 78]. Although the microscopic method is usually able to distinguish fish from land animal material, it is often unable to distinguish between different terrestrial animals. Fulfillments of the requirements of Regulation 1774/2002/EC laying down health rules concerning animal by-products not intended for human consumption, clearly implies that it must be possible to identify the origin animal materials, at higher taxonomic levels than in the past. Thus improvements in all methods of detecting constituents of animal origin are required, including the microscopic method. This article will examine the problem of meat and bone meal in animal feeds, and the use of microscopic methods in association with computer image analysis to identify the source species of these feedstuff contaminants. Image processing, integrated with morphometric measurements can provide accurate and reliable results and can be a very useful aid to the analyst in the characterization, analysis and control of feedstuffs.

  16. Exact analysis of Packet Reversed Packet Combining Scheme and Modified Packet Combining Scheme; and a combined scheme

    International Nuclear Information System (INIS)

    Bhunia, C.T.

    2007-07-01

    Packet combining scheme is a well defined simple error correction scheme for the detection and correction of errors at the receiver. Although it permits a higher throughput when compared to other basic ARQ protocols, packet combining (PC) scheme fails to correct errors when errors occur in the same bit locations of copies. In a previous work, a scheme known as Packet Reversed Packet Combining (PRPC) Scheme that will correct errors which occur at the same bit location of erroneous copies, was studied however PRPC does not handle a situation where a packet has more than 1 error bit. The Modified Packet Combining (MPC) Scheme that can correct double or higher bit errors was studied elsewhere. Both PRPC and MPC schemes are believed to offer higher throughput in previous studies, however neither adequate investigation nor exact analysis was done to substantiate this claim of higher throughput. In this work, an exact analysis of both PRPC and MPC is carried out and the results reported. A combined protocol (PRPC and MPC) is proposed and the analysis shows that it is capable of offering even higher throughput and better error correction capability at high bit error rate (BER) and larger packet size. (author)

  17. Synergistic target combination prediction from curated signaling networks: Machine learning meets systems biology and pharmacology.

    Science.gov (United States)

    Chua, Huey Eng; Bhowmick, Sourav S; Tucker-Kellogg, Lisa

    2017-10-01

    Given a signaling network, the target combination prediction problem aims to predict efficacious and safe target combinations for combination therapy. State-of-the-art in silico methods use Monte Carlo simulated annealing (mcsa) to modify a candidate solution stochastically, and use the Metropolis criterion to accept or reject the proposed modifications. However, such stochastic modifications ignore the impact of the choice of targets and their activities on the combination's therapeutic effect and off-target effects, which directly affect the solution quality. In this paper, we present mascot, a method that addresses this limitation by leveraging two additional heuristic criteria to minimize off-target effects and achieve synergy for candidate modification. Specifically, off-target effects measure the unintended response of a signaling network to the target combination and is often associated with toxicity. Synergy occurs when a pair of targets exerts effects that are greater than the sum of their individual effects, and is generally a beneficial strategy for maximizing effect while minimizing toxicity. mascot leverages on a machine learning-based target prioritization method which prioritizes potential targets in a given disease-associated network to select more effective targets (better therapeutic effect and/or lower off-target effects); and on Loewe additivity theory from pharmacology which assesses the non-additive effects in a combination drug treatment to select synergistic target activities. Our experimental study on two disease-related signaling networks demonstrates the superiority of mascot in comparison to existing approaches. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. The use of genre analysis in the design of electronic meeting systems

    Directory of Open Access Journals (Sweden)

    Pedro Antunes

    2006-01-01

    Full Text Available Introduction. Genre analysis is an approach to study communication patterns and thus it can be applied to the specific context of meetings. This research investigates the impact of genre analysis on the design of electronic meeting systems. Background. The primary goal of genre analysis is to understand how virtual communities use digital communication to collaborate. This knowledge is fundamental to inform IT design, particularly in areas where communication and informality are paramount. However, the research literature does not report any experiments where genre analysis has been used to inform electronic meeting system design. Problems. The paper tackles the following common problems found in current electronic meeting systems: (1 reduced organizational integration, neglecting many contextual cues and explaining factors necessary to make meeting outcomes usable within the organization; (2 lack of support to specific communities of users, stressing the dependency on a facilitator to configure and manage the technology; and (3 lack of support to meeting occurrences that span across long time periods. Conclusion. . The paper describes how genre analysis was used to develop electronic meeting systems for several organizations and meeting genres. It covers the complete design process, from genre elicitation to validation. The obtained results demonstrate that the genre approach produces electronic meeting systems focused on organizational integration, pre-configured to communities of users, supporting long-term usage and added organizational value.

  19. GeneLab Analysis Working Group Kick-Off Meeting

    Science.gov (United States)

    Costes, Sylvain V.

    2018-01-01

    Goals to achieve for GeneLab AWG - GL vision - Review of GeneLab AWG charter Timeline and milestones for 2018 Logistics - Monthly Meeting - Workshop - Internship - ASGSR Introduction of team leads and goals of each group Introduction of all members Q/A Three-tier Client Strategy to Democratize Data Physiological changes, pathway enrichment, differential expression, normalization, processing metadata, reproducibility, Data federation/integration with heterogeneous bioinformatics external databases The GLDS currently serves over 100 omics investigations to the biomedical community via open access. In order to expand the scope of metadata record searches via the GLDS, we designed a metadata warehouse that collects and updates metadata records from external systems housing similar data. To demonstrate the capabilities of federated search and retrieval of these data, we imported metadata records from three open-access data systems into the GLDS metadata warehouse: NCBI's Gene Expression Omnibus (GEO), EBI's PRoteomics IDEntifications (PRIDE) repository, and the Metagenomics Analysis server (MG-RAST). Each of these systems defines metadata for omics data sets differently. One solution to bridge such differences is to employ a common object model (COM) to which each systems' representation of metadata can be mapped. Warehoused metadata records are then transformed at ETL to this single, common representation. Queries generated via the GLDS are then executed against the warehouse, and matching records are shown in the COM representation (Fig. 1). While this approach is relatively straightforward to implement, the volume of the data in the omics domain presents challenges in dealing with latency and currency of records. Furthermore, the lack of a coordinated has been federated data search for and retrieval of these kinds of data across other open-access systems, so that users are able to conduct biological meta-investigations using data from a variety of sources. Such meta

  20. Analysis of a combined Rankine-vapour-compression refrigeration cycle

    International Nuclear Information System (INIS)

    Aphornratana, Satha; Sriveerakul, Thanarath

    2010-01-01

    This paper describes a theoretical analysis of a heat-powered refrigeration cycle, a combined Rankine-vapour-compression refrigeration cycle. This refrigeration cycle combines an Organic Rankine Cycle and a vapour-compression cycle. The cycle can be powered by low grade thermal energy as low as 60 deg. C and can produce cooling temperature as low as -10 deg. C. In the analysis, two combined Rankine-vapour-compression refrigeration cycles were investigated: the system with R22 and the system with R134a. Calculated COP values between 0.1 and 0.6 of both the systems were found.

  1. Structural analysis by load combination for conceptual design of HCCR TBM-set

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Dong Won, E-mail: dwlee@kaeri.re.kr [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Jin, Hyung Gon; Lee, Eo Hwak; Kim, Suk-Kwon; Yoon, Jae Sung; Park, Seong Dae [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Shin, Kyu In [Gentec Co., Daejeon (Korea, Republic of); Cho, Seungyon [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2016-11-01

    Highlights: • The structural analyses of the load combination are performed for the HCCR TBM-set. • Structural analyses are performed with the conventional CFD and FEM codes (ANSYS-CFX and ANSYS). • The results of stresses and deformations for all the loads conditions are confirmed to meet the design criteria. - Abstract: Using a conceptual design of the Korean Helium Cooled Ceramic Reflector (HCCR) Test Blanket Module (TBM) including the TBM-shield for testing in ITER, a structural analysis is performed according to the selected Load Combinations (LCs), which is described in the TBM Port Plug (TBM PP) System Load Specifications. Single load analyses are performed such as dead weight (DW), operating pressure (PresO), operating temperature (THO), electromagnetic (EM; MD-I, MD-II, and MD-IV), seismic (SL-1, SL-2, and SMHV), and in-TBM LOCA-IV. In addition, their results are superposed for the selected LCs. Through an analysis with 14 single load cases and 10 LC cases, it is confirmed that all load combination results meet the design criteria from the stress breakdown analysis according to the RCC-MRx.

  2. Large-scale exploration and analysis of drug combinations.

    Science.gov (United States)

    Li, Peng; Huang, Chao; Fu, Yingxue; Wang, Jinan; Wu, Ziyin; Ru, Jinlong; Zheng, Chunli; Guo, Zihu; Chen, Xuetong; Zhou, Wei; Zhang, Wenjuan; Li, Yan; Chen, Jianxin; Lu, Aiping; Wang, Yonghua

    2015-06-15

    Drug combinations are a promising strategy for combating complex diseases by improving the efficacy and reducing corresponding side effects. Currently, a widely studied problem in pharmacology is to predict effective drug combinations, either through empirically screening in clinic or pure experimental trials. However, the large-scale prediction of drug combination by a systems method is rarely considered. We report a systems pharmacology framework to predict drug combinations (PreDCs) on a computational model, termed probability ensemble approach (PEA), for analysis of both the efficacy and adverse effects of drug combinations. First, a Bayesian network integrating with a similarity algorithm is developed to model the combinations from drug molecular and pharmacological phenotypes, and the predictions are then assessed with both clinical efficacy and adverse effects. It is illustrated that PEA can predict the combination efficacy of drugs spanning different therapeutic classes with high specificity and sensitivity (AUC = 0.90), which was further validated by independent data or new experimental assays. PEA also evaluates the adverse effects (AUC = 0.95) quantitatively and detects the therapeutic indications for drug combinations. Finally, the PreDC database includes 1571 known and 3269 predicted optimal combinations as well as their potential side effects and therapeutic indications. The PreDC database is available at http://sm.nwsuaf.edu.cn/lsp/predc.php. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  3. AER Working Group D on VVER safety analysis - report of the 2009 meeting

    International Nuclear Information System (INIS)

    Kliem, S.

    2009-01-01

    The AER Working Group D on VVER reactor safety analysis held its 18-th meeting in Rez, Czech Republic, during the period 18-19 May, 2009. The meeting was hosted by the Nuclear Research Institute Rez. Altogether 17 participants attended the meeting of the working group D, 16 from AER member organizations and 1 guest from a non-member organization. The co-ordinator of the working group, S. Kliem, served as chairman of the meeting. The meeting started with a general information exchange about the recent activities in the participating organizations. The given presentations and the discussions can be attributed to the following topics: 1) Code validation and benchmarking; 2) Safety analysis and code developments; 3) Reactor pressure vessel thermal hydraulics; 4) Future activities including discussion on the participation in the OECD/NEA Benchmark for the Kalinin-3 NPP

  4. Analysis of Chromothripsis by Combined FISH and Microarray Analysis.

    Science.gov (United States)

    MacKinnon, Ruth N

    2018-01-01

    Fluorescence in situ hybridization (FISH) to metaphase chromosomes, in conjunction with SNP array, array CGH, or whole genome sequencing, can help determine the organization of abnormal genomes after chromothripsis and other types of complex genome rearrangement. DNA microarrays can identify the changes in copy number, but they do not give information on the organization of the abnormal chromosomes, balanced rearrangements, or abnormalities of the centromeres and other regions comprised of highly repetitive DNA. Many of these details can be determined by the strategic use of metaphase FISH. FISH is a single-cell technique, so it can identify low-frequency chromosome abnormalities, and it can determine which chromosome abnormalities occur in the same or different clonal populations. These are important considerations in cancer. Metaphase chromosomes are intact, so information about abnormalities of the chromosome homologues is preserved. Here we describe strategies for working out the organization of highly rearranged genomes by combining SNP array data with various metaphase FISH methods. This approach can also be used to address some of the uncertainties arising from whole genome or mate-pair sequencing data.

  5. Energy analysis handbook. CAC document 214. [Combining process analysis with input-output analysis

    Energy Technology Data Exchange (ETDEWEB)

    Bullard, C. W.; Penner, P. S.; Pilati, D. A.

    1976-10-01

    Methods are presented for calculating the energy required, directly and indirectly, to produce all types of goods and services. Procedures for combining process analysis with input-output analysis are described. This enables the analyst to focus data acquisition cost-effectively, and to achieve a specified degree of accuracy in the results. The report presents sample calculations and provides the tables and charts needed to perform most energy cost calculations, including the cost of systems for producing or conserving energy.

  6. NASA Technical Interchange Meeting (TIM): Advanced Technology Lifecycle Analysis System (ATLAS) Technology Tool Box

    Science.gov (United States)

    ONeil, D. A.; Craig, D. A.; Christensen, C. B.; Gresham, E. C.

    2005-01-01

    The objective of this Technical Interchange Meeting was to increase the quantity and quality of technical, cost, and programmatic data used to model the impact of investing in different technologies. The focus of this meeting was the Technology Tool Box (TTB), a database of performance, operations, and programmatic parameters provided by technologists and used by systems engineers. The TTB is the data repository used by a system of models known as the Advanced Technology Lifecycle Analysis System (ATLAS). This report describes the result of the November meeting, and also provides background information on ATLAS and the TTB.

  7. Report of the advisory group meeting on elemental analysis of extremely small samples

    International Nuclear Information System (INIS)

    2002-01-01

    This publication contains summary of discussions held at the meeting with brief description and comparative characteristics of most common nuclear analytical techniques used for analysis of very small samples as well as the conclusions of the meeting. Some aspect of reference materials and quality control are also discussed. The publication also contains individual contributions made by the participants, each of these papers haven provided with an abstract and indexed separately

  8. Third research coordination meeting on reference database for neutron activation analysis. Summary report

    International Nuclear Information System (INIS)

    Kellett, M.A.

    2009-12-01

    The third meeting of the Co-ordinated Research Project on 'Reference Database for Neutron Activation Analysis' was held at the IAEA, Vienna from 17-19 November 2008. A summary of presentations made by participants is given, reports on specific tasks and subsequent discussions. With the aim of finalising the work of this CRP and in order to meet initial objectives, outputs were discussed and detailed task assignments agreed upon. (author)

  9. Exergy analysis for combined regenerative Brayton and inverse Brayton cycles

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Zelong; Chen, Lingen; Sun, Fengrui [College of Naval Architecture and Power, Naval University of Engineering, Wuhan 430033 (China)

    2012-07-01

    This paper presents the study of exergy analysis of combined regenerative Brayton and inverse Brayton cycles. The analytical formulae of exergy loss and exergy efficiency are derived. The largest exergy loss location is determined. By taking the maximum exergy efficiency as the objective, the choice of bottom cycle pressure ratio is optimized by detailed numerical examples, and the corresponding optimal exergy efficiency is obtained. The influences of various parameters on the exergy efficiency and other performances are analyzed by numerical calculations.

  10. A Combined Metabolomic and Proteomic Analysis of Gestational Diabetes Mellitus

    OpenAIRE

    Hajduk, Joanna; Klupczynska, Agnieszka; Dereziński, Paweł; Matysiak, Jan; Kokot, Piotr; Nowak, Dorota; Gajęcka, Marzena; Nowak-Markwitz, Ewa; Kokot, Zenon

    2015-01-01

    The aim of this pilot study was to apply a novel combined metabolomic and proteomic approach in analysis of gestational diabetes mellitus. The investigation was performed with plasma samples derived from pregnant women with diagnosed gestational diabetes mellitus (n = 18) and a matched control group (n = 13). The mass spectrometry-based analyses allowed to determine 42 free amino acids and low molecular-weight peptide profiles. Different expressions of several peptides and altered amino acid ...

  11. Exergy analysis for combined regenerative Brayton and inverse Brayton cycles

    OpenAIRE

    Zelong Zhang, Lingen Chen, Fengrui Sun

    2012-01-01

    This paper presents the study of exergy analysis of combined regenerative Brayton and inverse Brayton cycles. The analytical formulae of exergy loss and exergy efficiency are derived. The largest exergy loss location is determined. By taking the maximum exergy efficiency as the objective, the choice of bottom cycle pressure ratio is optimized by detailed numerical examples, and the corresponding optimal exergy efficiency is obtained. The influences of various parameters on the exergy efficien...

  12. Working group on VVER safety analysis - report of the 2010 meeting

    International Nuclear Information System (INIS)

    Kliem, S.

    2010-01-01

    The AER Working Group D on WWER reactor safety analysis held its nineteenth meeting in Pisa, Italy, during the period 15-16 April, 2010. The meeting was hosted by the San Piero a Grado Nuclear Research Group of the University of Pisa and was held in conjunction with the second workshop on the OECD/NEA Benchmark for the Kalinin-3 WWER-1000 NPP and the fourth workshop on the OECD Benchmark for Uncertainty Analysis in Best-Estimate Modelling (UAM) for Design, Operation and Safety Analysis of LWRs. Altogether 12 participants attended the meeting of the working group D, 8 from AER member organizations and 4 guests from non-member organization. The co-ordinator of the working group, Mr. S. Kliem, served as chairman of the meeting. The meeting started with a general information exchange about the recent activities in the participating organizations. The given presentations and the discussions can be attributed to the following topics:-Code validation and benchmarking including the calculation of the OECD/NEA Benchmark for the Kalinin-3 WWER-1000 NPP;-Safety analyses and code developments;-Future activities A list of the participants and a list of the handouts distributed at the meeting are attached to the report. The corresponding PDF-files can be obtained from the chairman. (Author)

  13. Combined multi-criteria and cost-benefit analysis

    DEFF Research Database (Denmark)

    Moshøj, Claus Rehfeld

    1996-01-01

    The paper is an introduction to both theory and application of combined Cost-Benefit and Multi-Criteria Analysis. The first section is devoted to basic utility theory and its practical application in Cost-Benefit Analysis. Based on some of the problems encountered, arguments in favour...... of the application of utility-based Multi-Criteria Analyses methods as an extension and refinement of the traditional Cost-Benefit Analysis are provided. The theory presented in this paper is closely related the methods used in the WARP software (Leleur & Jensen, 1989). The presentation is however wider in scope.......The second section introduces the stated preference methodology used in WARP to create weight profiles for project pool sensitivity analysis. This section includes a simple example. The third section discusses how decision makers can get a priori aid to make their pair-wise comparisons based on project pool...

  14. Combined neutron activation analysis techniques for multiple purposes at Portuguese research reactor

    International Nuclear Information System (INIS)

    Dung, H.M.; Freitas, M.C.; Beasley, D.; Almeida, S.M.; Dionisio, I; Canha, N.H.; Galinha, C.; Marques, J.G.

    2010-01-01

    Full text: Developments of the neutron activation analysis (NAA) techniques using Compton suppression system (CSS), fast pneumatic irradiation facility (SIPRA), epithermal neutron and automatic sample changers (ASCs) associated with the traditional NAA for trace element determination in various sample types are described with reference to specific conditions at the 1 MW Portuguese research reactor (RPI). Experiences in application of k o -IAEA software for data processing in order to deduce the results are also discussed. A selected number of sample types which are intended to the application in biological and environmental areas as well as industrial and material samples are demonstrated which provide challenges in the irradiation, measurement and the interpretation of data to which in most cases a combined solution should be made. The role that each NAA technique can play in the combined scheme along with their optimized characteristics has been studied and shown. The combined NAA techniques at RPI established for on-going and potential projects as well as analysis service with respect to the element scope (48), typically Ag, Al, As, Au, Ba, Br, Ca, Cd, Ce, CI, Co, Cr, Cs, Cu, Dy, Er, Eu, F, Fe, Ga, Hf, Hg, I, In, K, La, Mg, Mn, Mo, Na, Rb, Sb, Sc, Se, Si, Sm, Sn, Sr, Ta, Tb, Th, Ti, U, V, W, Vb, Zn and Zr along with detection limits, accuracies and precision's have been evaluated as a trace analysis method meeting the requirements of the intended applications

  15. Transana Video Analysis Software as a Tool for Consultation: Applications to Improving PTA Meeting Leadership

    Science.gov (United States)

    Rush, Craig

    2012-01-01

    The chief aim of this article is to illustrate the potential of using Transana, a qualitative video analysis tool, for effective and efficient school-based consultation. In this illustrative study, the Transana program facilitated analysis of excerpts of video from a representative sample of Parent Teacher Association (PTA) meetings over the…

  16. 78 FR 21631 - NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting

    Science.gov (United States)

    2013-04-11

    ... the Audit, Finance and Analysis Committee of the NASA Advisory Council have been revised. The revised... 92-463, as amended, the National Aeronautics and Space Administration announces a meeting of the Audit, Finance and Analysis Committee of the NASA Advisory Council. DATES: Monday, April 22, 2013, 9:00...

  17. 77 FR 67677 - NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting

    Science.gov (United States)

    2012-11-13

    ... Statement Audit FY 2013 Financial Management Initiatives Administrative Savings NASA Budget Government..., Finance and Analysis Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION... Analysis Committee of the NASA Advisory Council. DATES: Monday, November 26, 2012, 9:00 a.m.-5:15 p.m...

  18. Meeting the reactor operator's information needs using functional analysis

    International Nuclear Information System (INIS)

    Nelson, W.R.; Clark, M.T.

    1980-01-01

    Since the accident at Three Mile Island, many ideas have been proposed for assisting the reactor operator during emergency situations. However, some of the suggested remedies do not alleviate an important shortcoming of the TMI control room: the operators were not presented with the information they needed in a manner which would allow prompt diagnosis of the problem. To address this problem, functional analysis is being applied at the LOFT facility to ensure that the operator's information needs are being met in his procedures and graphic displays. This paper summarizes the current applications of functional analysis at LOFT

  19. Metagenomics meets time series analysis: unraveling microbial community dynamics

    NARCIS (Netherlands)

    Faust, K.; Lahti, L.M.; Gonze, D.; Vos, de W.M.; Raes, J.

    2015-01-01

    The recent increase in the number of microbial time series studies offers new insights into the stability and dynamics of microbial communities, from the world's oceans to human microbiota. Dedicated time series analysis tools allow taking full advantage of these data. Such tools can reveal periodic

  20. 40 CFR 63.1446 - What alternative emission limitation may I meet for my combined gas streams?

    Science.gov (United States)

    2010-07-01

    ... than a baghouse or venturi wet scrubber applied to meet any total particulate matter emission limit in... than 5 percent of the total operating time in any semiannual reporting period. (d) For each venturi wet scrubber applied to meet any total particulate matter emission limit in paragraph (b) of this section, you...

  1. Funding for the 2ND IAEA technical meeting on fusion data processing, validation and analysis

    Energy Technology Data Exchange (ETDEWEB)

    Greenwald, Martin

    2017-06-02

    The International Atomic Energy Agency (IAEA) will organize the second Technical Meeting on Fusion Da Processing, Validation and Analysis from 30 May to 02 June, 2017, in Cambridge, MA USA. The meeting w be hosted by the MIT Plasma Science and Fusion Center (PSFC). The objective of the meeting is to provide a platform where a set of topics relevant to fusion data processing, validation and analysis are discussed with the view of extrapolation needs to next step fusion devices such as ITER. The validation and analysis of experimental data obtained from diagnostics used to characterize fusion plasmas are crucial for a knowledge based understanding of the physical processes governing the dynamics of these plasmas. The meeting will aim at fostering, in particular, discussions of research and development results that set out or underline trends observed in the current major fusion confinement devices. General information on the IAEA, including its mission and organization, can be found at the IAEA websit Uncertainty quantification (UQ) Model selection, validation, and verification (V&V) Probability theory and statistical analysis Inverse problems & equilibrium reconstru ction Integrated data analysis Real time data analysis Machine learning Signal/image proc essing & pattern recognition Experimental design and synthetic diagnostics Data management

  2. A Combined Metabolomic and Proteomic Analysis of Gestational Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Joanna Hajduk

    2015-12-01

    Full Text Available The aim of this pilot study was to apply a novel combined metabolomic and proteomic approach in analysis of gestational diabetes mellitus. The investigation was performed with plasma samples derived from pregnant women with diagnosed gestational diabetes mellitus (n = 18 and a matched control group (n = 13. The mass spectrometry-based analyses allowed to determine 42 free amino acids and low molecular-weight peptide profiles. Different expressions of several peptides and altered amino acid profiles were observed in the analyzed groups. The combination of proteomic and metabolomic data allowed obtaining the model with a high discriminatory power, where amino acids ethanolamine, l-citrulline, l-asparagine, and peptide ions with m/z 1488.59; 4111.89 and 2913.15 had the highest contribution to the model. The sensitivity (94.44% and specificity (84.62%, as well as the total group membership classification value (90.32% calculated from the post hoc classification matrix of a joint model were the highest when compared with a single analysis of either amino acid levels or peptide ion intensities. The obtained results indicated a high potential of integration of proteomic and metabolomics analysis regardless the sample size. This promising approach together with clinical evaluation of the subjects can also be used in the study of other diseases.

  3. Cost-benefit analysis for combined heat and power plant

    International Nuclear Information System (INIS)

    Sazdovski, Ace; Fushtikj, Vangel

    2004-01-01

    The paper presents a methodology and practical application of Cost-Benefit Analysis for Combined Heat and Power Plant (Cogeneration facility). Methodology include up-to-date and real data for cogeneration plant in accordance with the trends ill development of the CHP technology. As a case study a CHP plant that could be built-up in Republic of Macedonia is analyzed. The main economic parameters for project evaluation, such as NPV and IRR are calculated for a number of possible scenarios. The analyze present the economic outputs that could be used as a decision for CHP project acceptance for investment. (Author)

  4. Analysis of reactor strategies to meet world nuclear energy demands

    International Nuclear Information System (INIS)

    Ligon, D.M.; Brogli, R.H.

    1979-07-01

    A number of reactor deployment strategies for long-term nuclear system development are analyzed from a global perspective in terms of resource utilization and economic benefits. Two time frames are chosen: 1975 - 2025 and 1975 - 2050. Uranium demand for various strategies is compared with uranium supply assuming different production capabilities and resource base. The analysis shows that a given reactor deployment strategy could strongly influence the extent of uranium exploration and production. Power systems cost comparisons are made to identify clearly competitive or non-competitive reactors. The sensitivity of power cost to different uranium price projections and nuclear demands is also examined. The results indicate that breeders are necessary to support a long-term nuclear power system. Advanced converter-breeder symbiotic systems, particularly those operating on the Th/U-233 cycle, have clear advantages in terms of resources and economics

  5. Analysis meets geometry the Mikael Passare memorial volume

    CERN Document Server

    Boman, Jan; Kiselman, Christer; Kurasov, Pavel; Sigurdsson, Ragnar

    2017-01-01

    This book is dedicated to the memory of Mikael Passare, an outstanding Swedish mathematician who devoted his life to developing the theory of analytic functions in several complex variables and exploring geometric ideas first-hand. It includes several papers describing Mikael’s life as well as his contributions to mathematics, written by friends of Mikael’s who share his attitude and passion for science. A major section of the book presents original research articles that further develop Mikael’s ideas and which were written by his former students and co-authors. All these mathematicians work at the interface of analysis and geometry, and Mikael’s impact on their research cannot be underestimated. Most of the contributors were invited speakers at the conference organized at Stockholm University in his honor. This book is an attempt to express our gratitude towards this great mathematician, who left us full of energy and new creative mathematical ideas.

  6. XQCAT eXtra Quark Combined Analysis Tool

    CERN Document Server

    Barducci, D; Buchkremer, M; Marrouche, J; Moretti, S; Panizzi, L

    2015-01-01

    XQCAT (eXtra Quark Combined Analysis Tool) is a tool aimed to determine exclusion Confidence Levels (eCLs) for scenarios of new physics characterised by the presence of one or multiple heavy extra quarks (XQ) which interact through Yukawa couplings with any of the Standard Model (SM) quarks. The code uses a database of efficiencies for pre-simulated processes of Quantum Chromo-Dynamics (QCD) pair production and on-shell decays of extra quarks. In the version 1.0 of XQCAT the efficiencies have been computed for a set of seven publicly available search results by the CMS experiment, and the package is subject to future updates to include further searches by both ATLAS and CMS collaborations. The input for the code is a text file in which masses, branching ratios (BRs) and dominant chirality of the couplings of the new quarks are provided. The output of the code is the eCL of the test point for each implemented experimental analysis considered individually and, when possible, in statistical combination.

  7. Exergy analysis of a combined power and cooling cycle

    International Nuclear Information System (INIS)

    Fontalvo, Armando; Pinzon, Horacio; Duarte, Jorge; Bula, Antonio; Quiroga, Arturo Gonzalez; Padilla, Ricardo Vasquez

    2013-01-01

    This paper presents a comprehensive exergy analysis of a combined power and cooling cycle which combines a Rankine and absorption refrigeration cycle by using ammonia–water mixture as working fluid. A thermodynamic model was developed in Matlab ® to find out the effect of pressure ratio, ammonia mass fraction at the absorber and turbine efficiency on the total exergy destruction of the cycle. The contribution of each cycle component on the total exergy destruction was also determined. The results showed that total exergy destruction decreases when pressure ratio increases, and reaches a maximum at x ≈ 0.5, when ammonia mass fraction is varied at absorber. Also, it was found that the absorber, the boiler and the turbine had the major contribution to the total exergy destruction of the cycle, and the increase of the turbine efficiency reduces the total exergy destruction. The effect of rectification cooling source (external and internal) on the cycle output was investigated, and the results showed that internal rectification cooling reduces the total exergy destruction of the cycle. Finally, the effect of the presence or absence of the superheater after the rectification process was determined and it was obtained that the superheated condition reduces the exergy destruction of the cycle at high turbine efficiency values. Highlights: • A parametric exergy analysis of a combined power and cooling cycle is performed. • Two scenarios for rectifier cooling (internal and external) were studied. • Internal cooling source is more exergetic efficient than external cooling source. • The absorber and boiler have the largest total exergy destruction. • Our results show that the superheater reduces the exergy destruction of the cycle

  8. Numerical Analysis of Combined Valve Hydrodynamic Characteristics for Turbine System

    Energy Technology Data Exchange (ETDEWEB)

    Bhowmik, P. K.; Shamim, J. A.; Gairola, A.; Arif, M.; Suh, Kune Y. [Seoul National Univ., Seoul (Korea, Republic of)

    2014-05-15

    precisely by the valve manufacturer. As a matter of fact, attempts were made to obtain flow characteristic curves resorting to analytical as well as numerical methods. The flow characteristic curve relates the stem lift with mass flow rate at a specific temperature and pressure. This paper focuses on computational and numerical analysis of the combined stop and control valve. Combined Airflow Regulation Analysis (CARA) is performed to check on the hydrodynamic characteristic, which is represented by flow coefficient characteristic. CATIA V.5 and ANSYS CFX are used for three-dimensional computer-aided design and computational fluid dynamics (CFD) analysis, respectively. Flow characteristic curves are plotted by calculating theoretical and numerical mass flow rate. Hydrodynamic analysis was made of the combined stop and control valve for the turbine system using ANSYS CFX. The result of the numerical study represented by the valve flow coefficient with different normalized values of valve stem movement L/D and different pressure ratios of valve outlet and inlet agrees well with the ideal case and other similar previous experimental results. This study also provided a solid understanding with versatile options for analyzing the hydrodynamics of the combined valve considering the various internal geometry, seat, plug, and the inlet plus outlet boundary conditions to improve the efficiency, performance and reliability of the turbine system of small as well as large power conversion system using the numerical analysis with minimal cost and time.

  9. Numerical Analysis of Combined Valve Hydrodynamic Characteristics for Turbine System

    International Nuclear Information System (INIS)

    Bhowmik, P. K.; Shamim, J. A.; Gairola, A.; Arif, M.; Suh, Kune Y.

    2014-01-01

    precisely by the valve manufacturer. As a matter of fact, attempts were made to obtain flow characteristic curves resorting to analytical as well as numerical methods. The flow characteristic curve relates the stem lift with mass flow rate at a specific temperature and pressure. This paper focuses on computational and numerical analysis of the combined stop and control valve. Combined Airflow Regulation Analysis (CARA) is performed to check on the hydrodynamic characteristic, which is represented by flow coefficient characteristic. CATIA V.5 and ANSYS CFX are used for three-dimensional computer-aided design and computational fluid dynamics (CFD) analysis, respectively. Flow characteristic curves are plotted by calculating theoretical and numerical mass flow rate. Hydrodynamic analysis was made of the combined stop and control valve for the turbine system using ANSYS CFX. The result of the numerical study represented by the valve flow coefficient with different normalized values of valve stem movement L/D and different pressure ratios of valve outlet and inlet agrees well with the ideal case and other similar previous experimental results. This study also provided a solid understanding with versatile options for analyzing the hydrodynamics of the combined valve considering the various internal geometry, seat, plug, and the inlet plus outlet boundary conditions to improve the efficiency, performance and reliability of the turbine system of small as well as large power conversion system using the numerical analysis with minimal cost and time

  10. Combining network analysis with Cognitive Work Analysis: insights into social organisational and cooperation analysis.

    Science.gov (United States)

    Houghton, Robert J; Baber, Chris; Stanton, Neville A; Jenkins, Daniel P; Revell, Kirsten

    2015-01-01

    Cognitive Work Analysis (CWA) allows complex, sociotechnical systems to be explored in terms of their potential configurations. However, CWA does not explicitly analyse the manner in which person-to-person communication is performed in these configurations. Consequently, the combination of CWA with Social Network Analysis provides a means by which CWA output can be analysed to consider communication structure. The approach is illustrated through a case study of a military planning team. The case study shows how actor-to-actor and actor-to-function mapping can be analysed, in terms of centrality, to produce metrics of system structure under different operating conditions. In this paper, a technique for building social network diagrams from CWA is demonstrated.The approach allows analysts to appreciate the potential impact of organisational structure on a command system.

  11. Associations between meeting combinations of 24-h movement guidelines and health-related quality of life in children from 12 countries.

    Science.gov (United States)

    Sampasa-Kanyinga, H; Standage, M; Tremblay, M S; Katzmarzyk, P T; Hu, G; Kuriyan, R; Maher, C; Maia, J; Olds, T; Sarmiento, O L; Tudor-Locke, C; Chaput, J-P

    2017-12-01

    To examine whether meeting vs not meeting movement/non-movement guidelines (moderate-to-vigorous physical activity [MVPA], screen time, sleep duration), and combinations of these recommendations, are associated with health-related quality of life (HRQoL) in children from 12 countries in five major geographic regions of the world and explore whether the associations vary by study site. Observational, multinational cross-sectional study. This study included 6106 children aged 9-11 years from sites in Australia, Brazil, Canada, China, Colombia, Finland, India, Kenya, Portugal, South Africa, the United Kingdom, and the United States. Participants completed the KIDSCREEN-10 to provide a global measure of their HRQoL. Sleep duration and MVPA were assessed using 24-h accelerometry. Screen time was assessed through self-report. Meeting the recommendations was defined as ≥60 min/day for MVPA, ≤2 h/day for screen time, and between 9 and 11 h/night for sleep duration. Age, sex, highest parental education, unhealthy diet pattern score, and body mass index z-score were included as covariates in statistical models. In the full sample, children meeting the screen time recommendation, the screen time + sleep recommendation, and all three recommendations had significantly better HRQoL than children not meeting any of these guidelines. Differences in HRQoL scores between sites were also found within combinations of movement/non-movement behaviors. For example, while children in Australia, Canada, and USA self-reported better HRQoL when meeting all three recommendations, children in Kenya and Portugal reported significantly lower HRQoL when meeting all three recommendations (relative to not meeting any). Self-reported HRQoL is generally higher when children meet established movement/non-movement recommendations. However, differences between study sites also suggest that interventions aimed at improving lifestyle behaviors and HRQoL should be locally and culturally adapted

  12. Combined Bisulfite Restriction Analysis for brain tissue identification.

    Science.gov (United States)

    Samsuwan, Jarunya; Muangsub, Tachapol; Yanatatsaneejit, Pattamawadee; Mutirangura, Apiwat; Kitkumthorn, Nakarin

    2018-05-01

    According to the tissue-specific methylation database (doi: 10.1016/j.gene.2014.09.060), methylation at CpG locus cg03096975 in EML2 has been preliminarily proven to be specific to brain tissue. In this study, we enlarged sample size and developed a technique for identifying brain tissue in aged samples. Combined Bisulfite Restriction Analysis-for EML2 (COBRA-EML2) technique was established and validated in various organ samples obtained from 108 autopsies. In addition, this technique was also tested for its reliability, minimal DNA concentration detected, and use in aged samples and in samples obtained from specific brain compartments and spinal cord. COBRA-EML2 displayed 100% sensitivity and specificity for distinguishing brain tissue from other tissues, showed high reliability, was capable of detecting minimal DNA concentration (0.015ng/μl), could be used for identifying brain tissue in aged samples. In summary, COBRA-EML2 is a technique to identify brain tissue. This analysis is useful in criminal cases since it can identify the vital organ tissues from small samples acquired from criminal scenes. The results from this analysis can be counted as a medical and forensic marker supporting criminal investigations, and as one of the evidences in court rulings. Copyright © 2018 Elsevier B.V. All rights reserved.

  13. Micromechanical combined stress analysis: MICSTRAN, a user manual

    Science.gov (United States)

    Naik, R. A.

    1992-01-01

    Composite materials are currently being used in aerospace and other applications. The ability to tailor the composite properties by the appropriate selection of its constituents, the fiber and matrix, is a major advantage of composite materials. The Micromechanical Combined Stress Analysis (MICSTRAN) code provides the materials engineer with a user-friendly personal computer (PC) based tool to calculate overall composite properties given the constituent fiber and matrix properties. To assess the ability of the composite to carry structural loads, the materials engineer also needs to calculate the internal stresses in the composite material. MICSTRAN is a simple tool to calculate such internal stresses with a composite ply under combined thermomechanical loading. It assumes that the fibers have a circular cross-section and are arranged either in a repeating square or diamond array pattern within a ply. It uses a classical elasticity solution technique that has been demonstrated to calculate accurate stress results. Input to the program consists of transversely isotropic fiber properties and isotropic matrix properties such as moduli, Poisson's ratios, coefficients of thermal expansion, and volume fraction. Output consists of overall thermoelastic constants and stresses. Stresses can be computed under the combined action of thermal, transverse, longitudinal, transverse shear, and longitudinal shear loadings. Stress output can be requested along the fiber-matrix interface, the model boundaries, circular arcs, or at user-specified points located anywhere in the model. The MICSTRAN program is Windows compatible and takes advantage of the Microsoft Windows graphical user interface which facilitates multitasking and extends memory access far beyond the limits imposed by the DOS operating system.

  14. Combining morphological analysis and Bayesian networks for strategic decision support

    Directory of Open Access Journals (Sweden)

    A de Waal

    2007-12-01

    Full Text Available Morphological analysis (MA and Bayesian networks (BN are two closely related modelling methods, each of which has its advantages and disadvantages for strategic decision support modelling. MA is a method for defining, linking and evaluating problem spaces. BNs are graphical models which consist of a qualitative and quantitative part. The qualitative part is a cause-and-effect, or causal graph. The quantitative part depicts the strength of the causal relationships between variables. Combining MA and BN, as two phases in a modelling process, allows us to gain the benefits of both of these methods. The strength of MA lies in defining, linking and internally evaluating the parameters of problem spaces and BN modelling allows for the definition and quantification of causal relationships between variables. Short summaries of MA and BN are provided in this paper, followed by discussions how these two computer aided methods may be combined to better facilitate modelling procedures. A simple example is presented, concerning a recent application in the field of environmental decision support.

  15. Understanding intratumor heterogeneity by combining genome analysis and mathematical modeling.

    Science.gov (United States)

    Niida, Atsushi; Nagayama, Satoshi; Miyano, Satoru; Mimori, Koshi

    2018-04-01

    Cancer is composed of multiple cell populations with different genomes. This phenomenon called intratumor heterogeneity (ITH) is supposed to be a fundamental cause of therapeutic failure. Therefore, its principle-level understanding is a clinically important issue. To achieve this goal, an interdisciplinary approach combining genome analysis and mathematical modeling is essential. For example, we have recently performed multiregion sequencing to unveil extensive ITH in colorectal cancer. Moreover, by employing mathematical modeling of cancer evolution, we demonstrated that it is possible that this ITH is generated by neutral evolution. In this review, we introduce recent advances in a research field related to ITH and also discuss strategies for exploiting novel findings on ITH in a clinical setting. © 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

  16. Economical analysis of combined fuel cell generators and absorption chillers

    Directory of Open Access Journals (Sweden)

    M. Morsy El-Gohary

    2013-06-01

    Full Text Available This paper presents a co-generation system based on combined heat and power for commercial units. For installation of a co-generation system, certain estimates for this site should be performed through making assessments of electrical loads, domestic water, and thermal demand. This includes domestic hot water, selection of the type of power generator, fuel cell, and the type of air conditioning system, and absorption chillers. As a matter of fact, the co-generation system has demonstrated good results for both major aspects, economic and environmental. From the environmental point of view, this can be considered as an ideal solution for problems concerned with the usage of Chlorofluoro carbons. On the other hand, from the economic point of view, the cost analysis has revealed that the proposed system saves 4% of total cost through using the co-generation system.

  17. Investigation of fish otoliths by combined ion beam analysis

    International Nuclear Information System (INIS)

    Huszank, R.; Simon, A.; Keresztessy, K.

    2008-01-01

    Complete text of publication follows. This work was implemented within the framework of the Hungarian Ion beam Physics Platform (http://hipp.atomki.hu/). Otoliths are small structures, 'the ear stones' of a fish, and are used to detect acceleration and orientation. They are composed of a combination of protein matrix and calcium carbonate (CaCO 3 ) forming aragonite micro crystals. They have an annually deposited layered conformation with a microstructure corresponding to the seasonal and daily increments. Trace elements, such as Sr, Zn, Fe etc., are also incorporated into the otolith from the environment and the nutrition. The elemental distribution of the otolith of fresh water fish burbot (Lota lota L.) collected in Hungary was measured with Elastic Recoil Detection Analysis (ERDA), Rutherford backscattering spectrometry (RBS) and Particle Induced X-ray Emission (PIXE) at the Nuclear Microprobe Facility of HAS ATOMKI. The spatial 3D structure of the otolith could be observed with a sub-micrometer resolution. It is confirmed that the aragonite micro-crystals are covered by an organic layer and there are some protein rich regions in the otolith, too. By applying the RBSMAST code developed for RBS on macroscopic structure, it was proven that the orientation of the needle shaped aragonite crystals is considerably different at adjacent locations in the otolith. The organic and inorganic component of the otolith could be set apart in the depth selective hydrogen and calcium maps derived by micro- ERDA and micro-RBS. Similar structural analysis could be done near the surface by combining the C, O and Ca elemental maps determined by micro-PIXE measurements. It was observed that the trace metal Zn is bound to the protein component. Acknowledgements This work was partially supported by the Hungarian OTKA Grant No. T046238 and the EU cofunded Economic Competitiveness Operative Programme (GVOP-3.2.1.-2004-04-0402/3.0)

  18. A multimethod analysis of shared decision-making in hospice interdisciplinary team meetings including family caregivers.

    Science.gov (United States)

    Washington, Karla T; Oliver, Debra Parker; Gage, L Ashley; Albright, David L; Demiris, George

    2016-03-01

    Much of the existing research on shared decision-making in hospice and palliative care focuses on the provider-patient dyad; little is known about shared decision-making that is inclusive of family members of patients with advanced disease. We sought to describe shared decision-making as it occurred in hospice interdisciplinary team meetings that included family caregivers as participants using video-conferencing technology. We conducted a multimethod study in which we used content and thematic analysis techniques to analyze video-recordings of hospice interdisciplinary team meetings (n = 100), individual interviews of family caregivers (n = 73) and hospice staff members (n = 78), and research field notes. Participants in the original studies from which data for this analysis were drawn were hospice family caregivers and staff members employed by one of five different community-based hospice agencies located in the Midwestern United States. Shared decision-making occurred infrequently in hospice interdisciplinary team meetings that included family caregivers. Barriers to shared decision-making included time constraints, communication skill deficits, unaddressed emotional needs, staff absences, and unclear role expectations. The hospice philosophy of care, current trends in healthcare delivery, the interdisciplinary nature of hospice teams, and the designation of a team leader/facilitator supported shared decision-making. The involvement of family caregivers in hospice interdisciplinary team meetings using video-conferencing technology creates a useful platform for shared decision-making; however, steps must be taken to transform family caregivers from meeting attendees to shared decision-makers. © The Author(s) 2015.

  19. Report of the consultant's meeting on applications of accelerator based analysis

    International Nuclear Information System (INIS)

    1998-07-01

    At the present meeting, applications of accelerator based analytical methods, often referred as ion beam analysis (IBA) methods, to the following areas have been discussed: materials (including thin films), Earth sciences (including environmental studies), biology and medicine, art and archaeology (cultural heritage), and other applications (including forensic applications). This report gives brief overview of IBA applications in these areas, with short background about accelerators needed and corresponding analytical techniques

  20. Analysis of the Bias on the Beidou GEO Multipath Combinations

    Science.gov (United States)

    Ning, Yafei; Yuan, Yunbin; Chai, Yanju; Huang, Yong

    2016-01-01

    The Beidou navigation satellite system is a very important sensor for positioning in the Asia-Pacific region. The Beidou inclined geosynchronous orbit (IGSO) and medium Earth orbit (MEO) satellites have been analysed in some studies previously conducted by other researchers; this paper seeks to gain more insight regarding the geostationary earth orbit (GEO) satellites. Employing correlation analysis, Fourier transformation and wavelet decomposition, we validate whether there is a systematic bias in their multipath combinations. These biases can be observed clearly in satellites C01, C02 and C04 and have a great correlation with time series instead of elevation, being significantly different from those of the Beidou IGSO and MEO satellites. We propose a correction model to mitigate this bias based on its daily periodicity characteristic. After the model has been applied, the performance of the positioning estimations of the eight stations distributed in the Asia-Pacific region is evaluated and compared. The results show that residuals of multipath series behaves random noise; for the single point positioning (SPP) and precise point positioning (PPP) approaches, the positioning accuracy in the upward direction can be improved by 8 cm and 6 mm, respectively, and by 2 cm and 4 mm, respectively, for the horizontal component. PMID:27509503

  1. Energy Demand Forecasting: Combining Cointegration Analysis and Artificial Intelligence Algorithm

    Directory of Open Access Journals (Sweden)

    Junbing Huang

    2018-01-01

    Full Text Available Energy is vital for the sustainable development of China. Accurate forecasts of annual energy demand are essential to schedule energy supply and provide valuable suggestions for developing related industries. In the existing literature on energy use prediction, the artificial intelligence-based (AI-based model has received considerable attention. However, few econometric and statistical evidences exist that can prove the reliability of the current AI-based model, an area that still needs to be addressed. In this study, a new energy demand forecasting framework is presented at first. On the basis of historical annual data of electricity usage over the period of 1985–2015, the coefficients of linear and quadratic forms of the AI-based model are optimized by combining an adaptive genetic algorithm and a cointegration analysis shown as an example. Prediction results of the proposed model indicate that the annual growth rate of electricity demand in China will slow down. However, China will continue to demand about 13 trillion kilowatt hours in 2030 because of population growth, economic growth, and urbanization. In addition, the model has greater accuracy and reliability compared with other single optimization methods.

  2. Video stereolization: combining motion analysis with user interaction.

    Science.gov (United States)

    Liao, Miao; Gao, Jizhou; Yang, Ruigang; Gong, Minglun

    2012-07-01

    We present a semiautomatic system that converts conventional videos into stereoscopic videos by combining motion analysis with user interaction, aiming to transfer as much as possible labeling work from the user to the computer. In addition to the widely used structure from motion (SFM) techniques, we develop two new methods that analyze the optical flow to provide additional qualitative depth constraints. They remove the camera movement restriction imposed by SFM so that general motions can be used in scene depth estimation-the central problem in mono-to-stereo conversion. With these algorithms, the user's labeling task is significantly simplified. We further developed a quadratic programming approach to incorporate both quantitative depth and qualitative depth (such as these from user scribbling) to recover dense depth maps for all frames, from which stereoscopic view can be synthesized. In addition to visual results, we present user study results showing that our approach is more intuitive and less labor intensive, while producing 3D effect comparable to that from current state-of-the-art interactive algorithms.

  3. Combined HRTEM and PEELS analysis of nanoporous and amorphous carbon

    International Nuclear Information System (INIS)

    Peng, J.L.; Fan, X. D.; Bursill, L.A.

    1997-01-01

    Both the mass density (1.37 kgm/m 3 ) and sp 2 +sp 3 bonding fraction (0.15) were determined for an unusual nanoporous amorphous carbon consisting of curved single graphitic sheets. A combination of high-resolution transmission electron microscopy (HRTEM) and parallel electron energy loss spectroscopy (PEELS) was used. The values of these two parameters provide important constraints for the determination of the structure of this relatively low density variety of nanoporous carbon. The results are relevant also in the search for negatively-curved Schwarzite-related carbon structures. New date are also presented for highly-oriented pyrollytic graphite (HOPG), chemically vapour deposited (CVD) diamond, C 60 , glassy carbon (GC) and evaporated amorphous carbon (EAC); these are compared with the results for NAC. Kramers-Kronig analysis (KKA) of the low-loss PEELS data shows that the band gaps of both NAC and EAC are collapsed relative to that of CVD diamond. 18 refs., 2 tabs., 3 figs

  4. Analysis of the Bias on the Beidou GEO Multipath Combinations

    Directory of Open Access Journals (Sweden)

    Yafei Ning

    2016-08-01

    Full Text Available The Beidou navigation satellite system is a very important sensor for positioning in the Asia-Pacific region. The Beidou inclined geosynchronous orbit (IGSO and medium Earth orbit (MEO satellites have been analysed in some studies previously conducted by other researchers; this paper seeks to gain more insight regarding the geostationary earth orbit (GEO satellites. Employing correlation analysis, Fourier transformation and wavelet decomposition, we validate whether there is a systematic bias in their multipath combinations. These biases can be observed clearly in satellites C01, C02 and C04 and have a great correlation with time series instead of elevation, being significantly different from those of the Beidou IGSO and MEO satellites. We propose a correction model to mitigate this bias based on its daily periodicity characteristic. After the model has been applied, the performance of the positioning estimations of the eight stations distributed in the Asia-Pacific region is evaluated and compared. The results show that residuals of multipath series behaves random noise; for the single point positioning (SPP and precise point positioning (PPP approaches, the positioning accuracy in the upward direction can be improved by 8 cm and 6 mm, respectively, and by 2 cm and 4 mm, respectively, for the horizontal component.

  5. Combined HRTEM and PEELS analysis of nanoporous and amorphous carbon

    Energy Technology Data Exchange (ETDEWEB)

    Peng, J.L.; Fan, X. D.; Bursill, L.A.

    1997-06-01

    Both the mass density (1.37 kgm/m{sup 3}) and sp{sup 2}+sp{sup 3} bonding fraction (0.15) were determined for an unusual nanoporous amorphous carbon consisting of curved single graphitic sheets. A combination of high-resolution transmission electron microscopy (HRTEM) and parallel electron energy loss spectroscopy (PEELS) was used. The values of these two parameters provide important constraints for the determination of the structure of this relatively low density variety of nanoporous carbon. The results are relevant also in the search for negatively-curved Schwarzite-related carbon structures. New date are also presented for highly-oriented pyrollytic graphite (HOPG), chemically vapour deposited (CVD) diamond, C{sub 60}, glassy carbon (GC) and evaporated amorphous carbon (EAC); these are compared with the results for NAC. Kramers-Kronig analysis (KKA) of the low-loss PEELS data shows that the band gaps of both NAC and EAC are collapsed relative to that of CVD diamond. 18 refs., 2 tabs., 3 figs.

  6. International Atomic Energy Agency specialist meeting on advances in structural analysis for LMFBR applications. Summary report

    Energy Technology Data Exchange (ETDEWEB)

    Perez, M A; Roche, R L [eds.

    1983-05-01

    After the first session on review of national positions in the subject field, the meeting was divided into five technical sections as follows: General methods of Structural Analysis for Elevated Temperatures; Inelastic Analysis Methods for Elevated Temperature; Effects of Cyclic loading; Design Codes and Criteria; Instability and Buckling - Piping Analysis in the Creep Range. The conclusions of the Meeting were summarised as follows. In view of the complexity of material behaviour and the variability of properties from cast to cast, continuing work is needed to develop simple constitutive relations which ensure an acceptable level of conservatism for design evaluations. It is recognized that simplified design methods require further development for the assessment of ratchetting and shakedown of high temperature structures. More development work is required in the areas of buckling elastic follow up weld factors and these developments should take account of the imperfections inherent in welded fabrications. There is a need for realistic tests on welded structural features to validate design methods. It is proposed that this subject would be the topic of a future specialists meeting. In several countries, organisations are now preparing Guides and Codes concerning Structural Assessment for LMFBR components. It seems that some of these Codes could be drafted within a few years. In order to make a more realistic assessment of LMFBR structures, defect assessment in elevated temperature range must be considered.

  7. International Atomic Energy Agency specialist meeting on advances in structural analysis for LMFBR applications. Summary report

    International Nuclear Information System (INIS)

    Perez, M.A.; Roche, R.L.

    1983-05-01

    After the first session on review of national positions in the subject field, the meeting was divided into five technical sections as follows: General methods of Structural Analysis for Elevated Temperatures; Inelastic Analysis Methods for Elevated Temperature; Effects of Cyclic loading; Design Codes and Criteria; Instability and Buckling - Piping Analysis in the Creep Range. The conclusions of the Meeting were summarised as follows. In view of the complexity of material behaviour and the variability of properties from cast to cast, continuing work is needed to develop simple constitutive relations which ensure an acceptable level of conservatism for design evaluations. It is recognized that simplified design methods require further development for the assessment of ratchetting and shakedown of high temperature structures. More development work is required in the areas of buckling elastic follow up weld factors and these developments should take account of the imperfections inherent in welded fabrications. There is a need for realistic tests on welded structural features to validate design methods. It is proposed that this subject would be the topic of a future specialists meeting. In several countries, organisations are now preparing Guides and Codes concerning Structural Assessment for LMFBR components. It seems that some of these Codes could be drafted within a few years. In order to make a more realistic assessment of LMFBR structures, defect assessment in elevated temperature range must be considered

  8. Baseline correction combined partial least squares algorithm and its application in on-line Fourier transform infrared quantitative analysis.

    Science.gov (United States)

    Peng, Jiangtao; Peng, Silong; Xie, Qiong; Wei, Jiping

    2011-04-01

    In order to eliminate the lower order polynomial interferences, a new quantitative calibration algorithm "Baseline Correction Combined Partial Least Squares (BCC-PLS)", which combines baseline correction and conventional PLS, is proposed. By embedding baseline correction constraints into PLS weights selection, the proposed calibration algorithm overcomes the uncertainty in baseline correction and can meet the requirement of on-line attenuated total reflectance Fourier transform infrared (ATR-FTIR) quantitative analysis. The effectiveness of the algorithm is evaluated by the analysis of glucose and marzipan ATR-FTIR spectra. BCC-PLS algorithm shows improved prediction performance over PLS. The root mean square error of cross-validation (RMSECV) on marzipan spectra for the prediction of the moisture is found to be 0.53%, w/w (range 7-19%). The sugar content is predicted with a RMSECV of 2.04%, w/w (range 33-68%). Copyright © 2011 Elsevier B.V. All rights reserved.

  9. Second NASA Technical Interchange Meeting (TIM): Advanced Technology Lifecycle Analysis System (ATLAS) Technology Tool Box (TTB)

    Science.gov (United States)

    ONeil, D. A.; Mankins, J. C.; Christensen, C. B.; Gresham, E. C.

    2005-01-01

    The Advanced Technology Lifecycle Analysis System (ATLAS), a spreadsheet analysis tool suite, applies parametric equations for sizing and lifecycle cost estimation. Performance, operation, and programmatic data used by the equations come from a Technology Tool Box (TTB) database. In this second TTB Technical Interchange Meeting (TIM), technologists, system model developers, and architecture analysts discussed methods for modeling technology decisions in spreadsheet models, identified specific technology parameters, and defined detailed development requirements. This Conference Publication captures the consensus of the discussions and provides narrative explanations of the tool suite, the database, and applications of ATLAS within NASA s changing environment.

  10. Failure mode effect analysis and fault tree analysis as a combined methodology in risk management

    Science.gov (United States)

    Wessiani, N. A.; Yoshio, F.

    2018-04-01

    There have been many studies reported the implementation of Failure Mode Effect Analysis (FMEA) and Fault Tree Analysis (FTA) as a method in risk management. However, most of the studies usually only choose one of these two methods in their risk management methodology. On the other side, combining these two methods will reduce the drawbacks of each methods when implemented separately. This paper aims to combine the methodology of FMEA and FTA in assessing risk. A case study in the metal company will illustrate how this methodology can be implemented. In the case study, this combined methodology will assess the internal risks that occur in the production process. Further, those internal risks should be mitigated based on their level of risks.

  11. 13th New Mexico Analysis Seminar & Western Spring Sectional Meeting of the AMS

    CERN Document Server

    Marcantognini, Stefania; Stokolos, Alexander; Urbina, Wilfredo; Harmonic analysis, partial differential equations, complex analysis, Banach spaces, and operator theory : celebrating Cora Sadosky's life

    2016-01-01

    Covering a range of subjects from operator theory and classical harmonic analysis to Banach space theory, this book contains survey and expository articles by leading experts in their corresponding fields, and features fully-refereed, high-quality papers exploring new results and trends in spectral theory, mathematical physics, geometric function theory, and partial differential equations. Graduate students and researchers in analysis will find inspiration in the articles collected in this volume, which emphasize the remarkable connections between harmonic analysis and operator theory. Another shared research interest of the contributors of this volume lies in the area of applied harmonic analysis, where a new notion called chromatic derivatives has recently been introduced in communication engineering. The material for this volume is based on the 13th New Mexico Analysis Seminar held at the University of New Mexico, April 3-4, 2014 and on several special sections of the Western Spring Sectional Meeting at th...

  12. Development of a reference database for ion beam analysis. Summary report of the first research coordination meeting

    International Nuclear Information System (INIS)

    Vickridge, I.; Schwerer, O.

    2006-01-01

    A summary is given of the First Research Coordination Meeting on the Development of a Reference Database for Ion Beam Analysis, including background information, objectives, recommendations for measurements, and a list of tasks assigned to participants. The next research co-ordination meeting will be held in May 2007. (author)

  13. 77 FR 57545 - Long Term 2 Enhanced Surface Water Treatment Rule: Public Meeting on Monitoring Data Analysis...

    Science.gov (United States)

    2012-09-18

    ... Water Treatment Rule: Public Meeting on Monitoring Data Analysis, Occurrence Forecasts, Binning, and the... solicit public input on data and information related to several topics. The first topic is the results of... Review process. EPA will consider the data and/or information discussed at this meeting during the agency...

  14. AER working group D on WWER safety analysis - report of the 2007 meeting

    International Nuclear Information System (INIS)

    Kliem, S.

    2007-01-01

    The AER working group D on WWER reactor safety analysis held its sixteenth meeting in Paris, France during the period 08-09 May 2007. The meeting was hosted by the CEA France. It followed the final workshop on the OECD/DOE/CEA WWER-1000 Coolant Transient Benchmark held at 07 May. Altogether 11 participants attend the meeting of the working group D, 7 from AER member organizations and 4 guests from non-member organizations. The co-ordinator of the working group, Mr. S. Kliem, served as chairman of the meeting. The meeting started with a general information exchange about the recent activities in the participating organizations. The given presentations and the discussions can be attributed to the following topics: -Code development and benchmarking for reactor dynamics applications; -Safety analysis methodology and results; -Future activities. New solutions for three different benchmarks were presented and discussed. These are the Second AER Dynamic Benchmark on control rod ejection at hot zero power (S. Kliem, FZD), the WWER-1000 Coolant Transient Benchmark (E. Syrjaelahti, VTT) and the stationary AER-FCM101 Benchmark considering a WWER-1000 reactor (C. Parisi, UniPisa). A. Kereszturi (AEKI) presented a statistical evaluation of the possibility to observe a fuel assembly mis loading event. The second presentation of E. Syrjaelahti was dedicated to the description how best-estimate coupled code calculations at VTT are supported by uncertainty and sensitivity analyses. K. Velkov (GRS) presented preliminary results of BIPR8KN/ATHLET calculations with a very detailed resolution of the calculation grid on the assessment of coolant mixing inside WWER-1000 assembly heads. Coolant mixing experiments at three different mixing test facilities, modeling different reactor types, were presented and compared by S. Kliem. A calculation study using the coupled code system KORSAR/GP on the consequences of the injection of a slug of un borated water into the reactor core was

  15. Studies on upgrading quality of zircon concentrate to meet the standard for frit by a combination of using a screen plate electrostatic separator and other beneficiation methods

    International Nuclear Information System (INIS)

    Nguyen Duc Hung

    2003-01-01

    In the present work, researches on qualitative upgrade of zircon concentrate in order to meet the standard for frit were carried out by combinations of a screen plate type electrostatic separator with other physical beneficiation methods such as magnetic separation, flotation, gravity by air-table along with chemical treatment on laboratory scale was itself manufactured for studied scopes, after that zircon concentrate about 63.9-64.8% of ZrO 2 , less than 0.13% of TiO 2 and 0.128% of Fe 2 O 3 values were recovered. (NDH)

  16. Exergy analysis, parametric analysis and optimization for a novel combined power and ejector refrigeration cycle

    International Nuclear Information System (INIS)

    Dai Yiping; Wang Jiangfeng; Gao Lin

    2009-01-01

    A new combined power and refrigeration cycle is proposed, which combines the Rankine cycle and the ejector refrigeration cycle. This combined cycle produces both power output and refrigeration output simultaneously. It can be driven by the flue gas of gas turbine or engine, solar energy, geothermal energy and industrial waste heats. An exergy analysis is performed to guide the thermodynamic improvement for this cycle. And a parametric analysis is conducted to evaluate the effects of the key thermodynamic parameters on the performance of the combined cycle. In addition, a parameter optimization is achieved by means of genetic algorithm to reach the maximum exergy efficiency. The results show that the biggest exergy loss due to the irreversibility occurs in heat addition processes, and the ejector causes the next largest exergy loss. It is also shown that the turbine inlet pressure, the turbine back pressure, the condenser temperature and the evaporator temperature have significant effects on the turbine power output, refrigeration output and exergy efficiency of the combined cycle. The optimized exergy efficiency is 27.10% under the given condition.

  17. Development of a database for prompt γ-ray neutron activation analysis. Summary report of the first research coordination meeting

    International Nuclear Information System (INIS)

    Paviotti-Corcuera, R.; Lindstrom, R.M.

    2000-02-01

    This report summarizes the presentations, recommendations and conclusions of the First Research Co-ordination Meeting on Development of a Database for Prompt γ-ray Neutron Activation Analysis. Neutron-capture Prompt γ-ray Activation Analysis (PGAA) is a non-destructive radioanalytical method, capable of rapid or in-situ simultaneous multielement analysis of many elements of the Periodic Table, from hydrogen to uranium, in the same sample. Inaccuracy and incompleteness of the data available for use in PGAA are a significant handicap in the qualitative and quantitative analysis of capture-gamma spectra. The goal of this CRP is to replace the twenty-year-old data from a single laboratory with something fundamentally new: an evaluated database which includes a combination of evaluated nuclear physics data, physical theory, and recent measurements. The resulting database will be comparable in quality with that for radioactive decay. In addition, more accurate values of neutron capture cross-sections and γ-ray intensities that result from this database will improve the accuracy of radiation shielding calculations. (author)

  18. Alternate modal combination methods in response spectrum analysis

    International Nuclear Information System (INIS)

    Wang, Y.K.; Bezler, P.

    1989-01-01

    In piping analyses using the response spectrum method Square Root of the Sum of the Squares (SRSS) with clustering between closely spaced modes is the combination procedure most commonly used to combine between the modal response components. This procedure is simple to apply and normally yields conservative estimates of the time history results. The purpose of this study is to investigate alternate methods to combine between the modal response components. These methods are mathematically based to properly account for the combination between rigid and flexible modal responses as well as closely spaced modes. The methods are those advanced by Gupta, Hadjian and Lindley-Yow to address rigid response modes and the Double Sum Combination (DSC) method and the Complete Quadratic Combination (CQC) method to account for closely spaced modes. A direct comparison between these methods as well as the SRSS procedure is made by using them to predict the response of six piping systems. For two piping systems thirty-three earthquake records were considered to account for the impact of variations in the characteristics of the excitation. The results provided by each method are compared to the corresponding time history estimates of results as well as to each other. The degree of conservatism associated with each method is characterized. 7 refs., 4 figs., 2 tabs

  19. Alternate modal combination methods in response spectrum analysis

    International Nuclear Information System (INIS)

    Bezler, P.; Curreri, J.R.; Wang, Y.K.; Gupta, A.K.

    1990-10-01

    In piping analyses using the response spectrum method Square Root of the Sum of the Squares (SRSS) with clustering between closely spaced modes is the combination procedure most commonly used to combine between the modal response components. This procedure is simple to apply and normally yields conservative estimates of the time history results. The purpose of this study is to investigate alternate methods to combine between the modal response components. These methods are mathematically based to properly account for the combination between rigid and flexible modal responses as well as closely spaced modes. The methods are those advanced by Gupta, Hadjian and Lindely-Yow to address rigid response modes and the Double Sum Combination (DSC) method and the Complete Quadratic Combination (CQC) method to account for closely spaced modes. A direct comparison between these methods as well as the SRSS procedure is made by using them to predict the response of six piping systems. The results provided by each method are compared to the corresponding time history estimates of results as well as to each other. The degree of conservatism associated with each method is characterized. 19 refs., 16 figs., 10 tabs

  20. 'AER Working Group D On WWER Safety Analysis' Report Of The Meeting In Pisa, Italy, 26-27 April 2006

    International Nuclear Information System (INIS)

    Siltanen, P.

    2006-01-01

    AER Working Group D on WWER reactor safety analysis held its 15 t h meeting in Grand Hotel Duomo in Pisa, Italy during the period 26-27 April 2006. The meeting was hosted by the University of Pisa following the fourth workshop on the OECD/DOE/CEA WWER-1000 Coolant Transient Benchmark (W1000-CT) held at the same location on 24-25 April. Altogether 15 participants attended the Working Group D meeting, 11 from AER member organizations and 4 guests from non-member organizations. The coordinator for the working group, Mr. P. Siltanen (FNS) served as chairman. In addition to general information exchange on recent activities in the participating organizations, the topics of the meeting included: 1) Code development and benchmarking for reactor dynamics applications. 2) Safety analysis methodology and results. 3) Future activities. A list of participants and a list of handouts distributed at the meeting are attached to the report (Author)

  1. Nearly Finished Genomes Produced Using Gel Microdroplet Culturing (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)

    Energy Technology Data Exchange (ETDEWEB)

    Fitzsimmons, Michael

    2012-06-01

    Michael Fitzsimmons from Los Alamos National Laboratory gives a talk titled "Nearly Finished Genomes Produced Using Gel Microdroplet Culturing" at the 7th Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held in June, 2012 in Santa Fe, NM.

  2. Alice and Bob meet Banach the interface of asymptotic geometric analysis and quantum information theory

    CERN Document Server

    Aubrun, Guillaume

    2017-01-01

    The quest to build a quantum computer is arguably one of the major scientific and technological challenges of the twenty-first century, and quantum information theory (QIT) provides the mathematical framework for that quest. Over the last dozen or so years, it has become clear that quantum information theory is closely linked to geometric functional analysis (Banach space theory, operator spaces, high-dimensional probability), a field also known as asymptotic geometric analysis (AGA). In a nutshell, asymptotic geometric analysis investigates quantitative properties of convex sets, or other geometric structures, and their approximate symmetries as the dimension becomes large. This makes it especially relevant to quantum theory, where systems consisting of just a few particles naturally lead to models whose dimension is in the thousands, or even in the billions. Alice and Bob Meet Banach is aimed at multiple audiences connected through their interest in the interface of QIT and AGA: at quantum information resea...

  3. Microscopes and computers combined for analysis of chromosomes

    Science.gov (United States)

    Butler, J. W.; Butler, M. K.; Stroud, A. N.

    1969-01-01

    Scanning machine CHLOE, developed for photographic use, is combined with a digital computer to obtain quantitative and statistically significant data on chromosome shapes, distribution, density, and pairing. CHLOE permits data acquisition about a chromosome complement to be obtained two times faster than by manual pairing.

  4. Analysis of induction machines with combined stator windings

    Czech Academy of Sciences Publication Activity Database

    Schreier, Luděk; Bendl, Jiří; Chomát, Miroslav

    2015-01-01

    Roč. 60, č. 2 (2015), s. 155-171 ISSN 0001-7043 R&D Projects: GA ČR GA13-35370S Institutional support: RVO:61388998 Keywords : induction machines * symmetrical components * combined stator winding Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering

  5. Repeater Analysis for Combining Information from Different Assessments

    Science.gov (United States)

    Haberman, Shelby; Yao, Lili

    2015-01-01

    Admission decisions frequently rely on multiple assessments. As a consequence, it is important to explore rational approaches to combine the information from different educational tests. For example, U.S. graduate schools usually receive both TOEFL iBT® scores and GRE® General scores of foreign applicants for admission; however, little guidance…

  6. ApkCombiner: Combining Multiple Android Apps to Support Inter-App Analysis

    OpenAIRE

    Li , Li; Bartel , Alexandre; Bissyandé , Tegawendé ,; Klein , Jacques; Traon , Yves ,

    2015-01-01

    Part 8: Mobile and Cloud Services Security; International audience; Android apps are made of components which can leak information between one another using the ICC mechanism. With the growing momentum of Android, a number of research contributions have led to tools for the intra-app analysis of Android apps. Unfortunately, these state-of-the-art approaches, and the associated tools, have long left out the security flaws that arise across the boundaries of single apps, in the interaction betw...

  7. Combining Formal Logic and Machine Learning for Sentiment Analysis

    DEFF Research Database (Denmark)

    Petersen, Niklas Christoffer; Villadsen, Jørgen

    2014-01-01

    This paper presents a formal logical method for deep structural analysis of the syntactical properties of texts using machine learning techniques for efficient syntactical tagging. To evaluate the method it is used for entity level sentiment analysis as an alternative to pure machine learning...

  8. Inserting Stress Analysis of Combined Hexagonal Aluminum Honeycombs

    Directory of Open Access Journals (Sweden)

    Xiangcheng Li

    2016-01-01

    Full Text Available Two kinds of hexagonal aluminum honeycombs are tested to study their out-of-plane crushing behavior. In the tests, honeycomb samples, including single hexagonal aluminum honeycomb (SHAH samples and two stack-up combined hexagonal aluminum honeycombs (CHAH samples, are compressed at a fixed quasistatic loading rate. The results show that the inserting process of CHAH can erase the initial peak stress that occurred in SHAH. Meanwhile, energy-absorbing property of combined honeycomb samples is more beneficial than the one of single honeycomb sample with the same thickness if the two types of honeycomb samples are completely crushed. Then, the applicability of the existing theoretical model for single hexagonal honeycomb is discussed, and an area equivalent method is proposed to calculate the crushing stress for nearly regular hexagonal honeycombs. Furthermore, a semiempirical formula is proposed to calculate the inserting plateau stress of two stack-up CHAH, in which structural parameters and mechanics properties of base material are concerned. The results show that the predicted stresses of three kinds of two stack-up combined honeycombs are in good agreement with the experimental data. Based on this study, stress-displacement curve of aluminum honeycombs can be designed in detail, which is very beneficial to optimize the energy-absorbing structures in engineering fields.

  9. Combinations of options: Methodology for impact analysis. Development plan 1993

    International Nuclear Information System (INIS)

    1992-01-01

    The orientations favored by Hydro-Quebec in terms of electricity supply and demand are based on a few key selection criteria. These criteria, as described in its development plan, pertain to economic benefit for the utility and its customers, compatibility with sustainable development, minimization of costs to customers, preservation of the utility's financial health, generation of economic spinoffs, and ease of adaptation. Impacts are calculated to illustrate the selection criteria. The main methods, assumptions, and components used in evaluating the various impacts are described. The discounted overall cost for Hydro-Quebec and all of its customers, means of meeting electricity requirements, and the economic benefit for Hydro-Quebec of the various market development options are discussed. The indicators chosen for environmental impact assessment are set forth and the method used to calculate long-term supply costs is presented, along with the methods for calculating economic spinoffs. Finally, the concepts of energy mix and energy self-sufficiency are outlined. 1 tab

  10. A Thermorisk framework for the analysis of energy systems by combining risk and exergy analysis

    International Nuclear Information System (INIS)

    Cassetti, G.; Colombo, E.; Zio, E.

    2016-01-01

    Highlights: • An exergy based analysis for improving efficiency and safety of energy systems is presented. • The relation between thermodynamic parameters and the safety characteristics is identified. • Possible modifications in the process are indicated to improve the safety of the system. - Abstract: The impact of energy production, transformation and use on the environmental resources encourage to understand the mechanisms of resource degradation and to develop proper analyses to reduce the impact of the energy systems on the environment. At the technical level, most attempts for reducing the environmental impact of energy systems focus on the improvement of process efficiency. One way toward an integrated approach is that of adopting exergy analysis for assessing efficiency and test improving design and operation solutions. The paper presents an exergy based analysis for improving efficiency and safety of energy systems, named Thermorisk analysis. The purpose of the Thermorisk analysis is to supply information to control, and eventually reduce, the risk of the systems (i.e. risk of accidents) by acting on the thermodynamic parameters and safety characteristics in the same frame. The proper combination of exergy and risk analysis allows monitoring the effects of efficiency improvement on the safety of the systems analyzed. A case study is presented, showing the potential of the analysis to identify the relation between the exergy efficiency and the risk of the system analyzed, and the contribution of inefficiencies on the safety of the process. Possible modifications in the process are indicated to improve the safety of the system.

  11. Combining morphological analysis and Bayesian Networks for strategic decision support

    CSIR Research Space (South Africa)

    De Waal, AJ

    2007-12-01

    Full Text Available Morphological analysis (MA) and Bayesian networks (BN) are two closely related modelling methods, each of which has its advantages and disadvantages for strategic decision support modelling. MA is a method for defining, linking and evaluating...

  12. Combined process automation for large-scale EEG analysis.

    Science.gov (United States)

    Sfondouris, John L; Quebedeaux, Tabitha M; Holdgraf, Chris; Musto, Alberto E

    2012-01-01

    Epileptogenesis is a dynamic process producing increased seizure susceptibility. Electroencephalography (EEG) data provides information critical in understanding the evolution of epileptiform changes throughout epileptic foci. We designed an algorithm to facilitate efficient large-scale EEG analysis via linked automation of multiple data processing steps. Using EEG recordings obtained from electrical stimulation studies, the following steps of EEG analysis were automated: (1) alignment and isolation of pre- and post-stimulation intervals, (2) generation of user-defined band frequency waveforms, (3) spike-sorting, (4) quantification of spike and burst data and (5) power spectral density analysis. This algorithm allows for quicker, more efficient EEG analysis. Copyright © 2011 Elsevier Ltd. All rights reserved.

  13. Stochastic analysis of residential micro combined heat and power system

    DEFF Research Database (Denmark)

    Karami, H.; Sanjari, M. J.; Gooi, H. B.

    2017-01-01

    In this paper the combined heat and power functionality of a fuel-cell in a residential hybrid energy system, including a battery, is studied. The demand uncertainties are modeled by investigating the stochastic load behavior by applying Monte Carlo simulation. The colonial competitive algorithm...... algorithm. The optimized scheduling of different energy resources is listed in an efficient look-up table for all time intervals. The effects of time of use and the battery efficiency and its size are investigated on the operating cost of the hybrid energy system. The results of this paper are expected...

  14. ANALYSIS OF COMBINED POLYSURFACES TO MESH SURFACES MATCHING

    Directory of Open Access Journals (Sweden)

    Marek WYLEŻOŁ

    2014-06-01

    Full Text Available This article applies to an example of the process of quantitatively evaluate the fit of combined polysurface (NURBS class to a surface mesh. The fitting process of the polysurface and the evaluation of obtained results have been realized in the environment of the CATIA v5 system. Obtained quantitative evaluation are shown graphically in the form of three-dimensional graphs and histograms. As the base surface mesh was used a pelvic bone stl model (the model was created by digitizing didactic physical model.

  15. A unified MGF-based capacity analysis of diversity combiners over generalized fading channels

    KAUST Repository

    Yilmaz, Ferkan; Alouini, Mohamed-Slim

    2012-01-01

    Unified exact ergodic capacity results for L-branch coherent diversity combiners including equal-gain combining (EGC) and maximal-ratio combining (MRC) are not known. This paper develops a novel generic framework for the capacity analysis of L-branch

  16. Development of a database for prompt γ-ray neutron activation analysis. Summary report of the second research coordination meeting

    International Nuclear Information System (INIS)

    Lone, M.A.; Mughabghab, S.F.; Paviotti-Corcuera, R.

    2001-06-01

    This report summarizes the presentations, recommendations and conclusions of the Second Research Co-ordination Meeting on Development of a Database for Prompt γ-ray Neutron Activation Analysis. The purpose of this meeting was to review results achieved on the development of the database, discuss further developments and planning of the products ol this CRP. Actions to be taken were agreed upon with the aim to complete the project by the end of 2002. (author)

  17. Comparison of Outputs for Variable Combinations Used in Cluster Analysis on Polarmetric Imagery

    National Research Council Canada - National Science Library

    Petre, Melinda

    2008-01-01

    .... More specifically, two techniques, Cluster Analysis (CA) and Principle Component Analysis (PCA) can be combined to process Stoke s imagery by distinguishing between pixels, and producing groups of pixels with similar characteristics...

  18. CFD analysis of ejector in a combined ejector cooling system

    Energy Technology Data Exchange (ETDEWEB)

    Rusly, E.; Aye, Lu [International Technologies Centre (IDTC), Department of Civil and Environmental Engineering, The University of Melbourne, Melbourne, Vic. 3010 (Australia); Charters, W.W.S.; Ooi, A. [Department of Mechanical and Manufacturing Engineering, The University of Melbourne, Melbourne, Vic. 3010 (Australia)

    2005-11-01

    One-dimensional ejector analyses often use coefficients derived from experimental data for a set of operating conditions with limited functionality. In this study, several ejector designs were modelled using finite volume CFD techniques to resolve the flow dynamics in the ejectors. The CFD results were validated with available experimental data. Flow field analyses and predictions of ejector performance outside the experimental range were also carried out. During validation, data from CFD predicted the entrainment ratios with greater accuracy on definite area ratios, although no shock was recorded in the ejector. Predictions outside the experimental range-at operating conditions in a combined ejector-vapour compression system-and flow conditions resulting from ejector geometry variations are discussed. It is found that the maximum entrainment ratio happens in the ejector just before a shock occurs and that the position of the nozzle is an important ejector design parameter. (author)

  19. Texture, residual stress and structural analysis of thin films using a combined X-ray analysis

    International Nuclear Information System (INIS)

    Lutterotti, L.; Chateigner, D.; Ferrari, S.; Ricote, J.

    2004-01-01

    Advanced thin films for today's industrial and research needs require highly specialized methodologies for a successful quantitative characterization. In particular, in the case of multilayer and/or unknown phases a global approach is necessary to obtain some or all the required information. A full approach has been developed integrating novel texture and residual stress methodologies with the Rietveld method (Acta Cryst. 22 (1967) 151) (for crystal structure analysis) and it has been coupled with the reflectivity analysis. The complete analysis can be done at once and offers several benefits: the thicknesses obtained from reflectivity can be used to correct the diffraction spectra, the phase analysis help to identify the layers and to determine the electron density profile for reflectivity; quantitative texture is needed for quantitative phase and residual stress analyses; crystal structure determination benefits of the previous. To achieve this result, it was necessary to develop some new methods, especially for texture and residual stresses. So it was possible to integrate them in the Rietveld, full profile fitting of the patterns. The measurement of these spectra required a special reflectometer/diffractometer that combines a thin parallel beam (for reflectivity) and a texture/stress goniometer with a curved large position sensitive detector. This new diffraction/reflectivity X-ray machine has been used to test the combined approach. Several spectra and the reflectivity patterns have been collected at different tilting angles and processed at once by the special software incorporating the aforementioned methodologies. Some analysis examples will be given to show the possibilities offered by the method

  20. Computational heat transfer analysis and combined ANN–GA ...

    Indian Academy of Sciences (India)

    The analysis using the numerical simulation and neural network ... Optimization is the process of finding the most plausible and desirable solution to a problem. ... increased heat transfer and compared the results of regular non-fuzzy model and fuzzy model. ..... network is designed using MATLAB Neural network toolbox.

  1. Advantages of shift changeovers with meetings: ergonomic analysis of shift supervisors' activity in aircraft building.

    Science.gov (United States)

    Le Bris, Valérie; Barthe, Béatrice; Marquié, Jean-Claude; Kerguelen, Alain; Aubert, Sophie; Bernadou, Bernadette

    2012-03-01

    Good shift changeovers contribute to ensuring continuity and reliability in shift work. In situations where production is not maintained 24 h a day, changeovers with meetings (SCM) between the two work teams (written plus oral face-to-face handovers) alternate with changeovers without meetings (SCnM; written handovers only). An ergonomic work analysis on an aircraft assembly line showed that (1) incoming and outgoing operators met during the overlap time allotted by the company, and (2) the content of the exchanges was richer for SCMs than for SCnMs. SCMs enabled the operators to pass on and process more aspects of their work than SCnMs did. SCMs also allowed incoming operators to validate their predictions, and enabled both outgoing and incoming operators to update their mental models and work together on peripheral aspects of the technical process over a greater time span. The findings highlight the importance of allowing overlap time in shift work. Copyright © 2011 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  2. Tweeting the meeting: A comparative analysis of an Australian emergency medicine conference over four years

    Directory of Open Access Journals (Sweden)

    Cristian Udovicich

    2016-01-01

    Full Text Available Objective: Social media allows user-generated content and dialog between users and has also entered into the domain of healthcare. The purpose of this study was to compare the use of Twitter at the Australasian College of Emergency Medicine Annual Scientific Meeting (ACEM ASM from 2011 to 2014 and analyze its ability to spread emergency medicine education. Materials and Methods: Retrospectively, TweetReach was utilized to analyze relevant tweets. Each Annual Scientific Meeting (ASM had an associated Twitter account/s from, which data were collected. Duplicate tweets were excluded from the analysis. Information on the number of total tweets (regular tweets, retweets, and replies and contributors was gathered. The potential audience, the reach, was calculated. Results: From 2011 to 2014 the number of tweets rose from 460 to 4694, a 920% increase. Only 54 Twitter users contributed to the 2011 ASM. This rose to 252 (2012, 291 (2013 and 572 (2014. The average number of tweets per contributor ranged from 8.2 to 10.9. The reach, the potential number of Twitter users exposed to posts, rose >30 times from 2011 (15,502 users to 2014 (471,166. Conclusion: The use of Twitter at the ACEM ASM rose significantly from 2011 to 2014. It is a highly useful tool for the dissemination of emergency medicine education. Twitter has been harnessed by the ASM to enhance the conference experience by further generating interaction between delegates as well as those worldwide.

  3. Tweeting the meeting: A comparative analysis of an Australian emergency medicine conference over four years.

    Science.gov (United States)

    Udovicich, Cristian; Barberi, Anthony; Perera, Kalpa

    2016-01-01

    Social media allows user-generated content and dialog between users and has also entered into the domain of healthcare. The purpose of this study was to compare the use of Twitter at the Australasian College of Emergency Medicine Annual Scientific Meeting (ACEM ASM) from 2011 to 2014 and analyze its ability to spread emergency medicine education. Retrospectively, TweetReach was utilized to analyze relevant tweets. Each Annual Scientific Meeting (ASM) had an associated Twitter account/s from, which data were collected. Duplicate tweets were excluded from the analysis. Information on the number of total tweets (regular tweets, retweets, and replies) and contributors was gathered. The potential audience, the reach, was calculated. From 2011 to 2014 the number of tweets rose from 460 to 4694, a 920% increase. Only 54 Twitter users contributed to the 2011 ASM. This rose to 252 (2012), 291 (2013) and 572 (2014). The average number of tweets per contributor ranged from 8.2 to 10.9. The reach, the potential number of Twitter users exposed to posts, rose >30 times from 2011 (15,502 users) to 2014 (471,166). The use of Twitter at the ACEM ASM rose significantly from 2011 to 2014. It is a highly useful tool for the dissemination of emergency medicine education. Twitter has been harnessed by the ASM to enhance the conference experience by further generating interaction between delegates as well as those worldwide.

  4. Meeting rural demand: a case for combining community-based distribution and social marketing of injectable contraceptives in Tigray, Ethiopia.

    Science.gov (United States)

    Prata, Ndola; Weidert, Karen; Fraser, Ashley; Gessessew, Amanuel

    2013-01-01

    In Sub-Saharan Africa, policy changes have begun to pave the way for community distribution of injectable contraceptives but sustaining such efforts remains challenging. Combining social marketing with community-based distribution provides an opportunity to recover some program costs and compensate workers with proceeds from contraceptive sales. This paper proposes a model for increasing access to injectable contraceptives in rural settings by using community-based distributers as social marketing agents and incorporating financing systems to improve sustainability. This intervention was implemented in three districts of the Central Zone of Tigray, Ethiopia and program data has been collected from November 2011 through October 2012. A total of 137 Community Based Reproductive Health Agents (CBRHAs) were trained to provide injectable contraceptives and were provided with a loan of 25 injectable contraceptives from a drug revolving fund, created with project funds. The price of a single dose credited to a CBRHA was 3 birr ($0.17) and they provide injections to women for 5 birr ($0.29), determined with willingness-to-pay data. Social marketing was used to create awareness and generate demand. Both quantitative and qualitative methods were used to examine important feasibility aspects of the intervention. Forty-four percent of CBRHAs were providing family planning methods at the time of the training and 96% believed providing injectable contraceptives would improve their services. By October 2012, 137 CBRHAs had successfully completed training and provided 2541 injections. Of total injections, 47% were provided to new users of injectable contraceptives. Approximately 31% of injections were given for free to the poorest women, including adolescents. Insights gained from the first year of implementation of the model provide a framework for further expansion in Tigray, Ethiopia. Our experience highlights how program planners can tailor interventions to match family

  5. Do green building assessment criteria meet sustainability imperatives: a critical analysis

    CSIR Research Space (South Africa)

    Van Wyk, Llewellyn V

    2008-07-01

    Full Text Available The purpose of this paper is to determine whether green building assessment criteria meet the imperatives of sustainable development. The paper finds that green building assessment criteria fail to meet the sustainable development imperatives...

  6. Combined Aero and Underhood Thermal Analysis for Heavy Duty Trucks

    Energy Technology Data Exchange (ETDEWEB)

    Vegendla, Prasad [Argonne National Lab. (ANL), Argonne, IL (United States); Sofu, Tanju [Argonne National Lab. (ANL), Argonne, IL (United States); Saha, Rohit [Cummins Inc., Columbus, IN (United States); Madurai Kumar, Mahesh [Cummins Inc., Columbus, IN (United States); Hwang, L. K [Cummins Inc., Columbus, IN (United States)

    2017-01-31

    Aerodynamic analysis of the medium-duty delivery truck was performed to achieve vehicle design optimization. Three dimensional CFD simulations were carried out for several improved designs, with a detailed external component analysis of wheel covers, side skirts, roof fairings, and rounded trailer corners. The overall averaged aerodynamics drag reduction through the design modifications were shown up to 22.3% through aerodynamic considerations alone, which is equivalent to 11.16% fuel savings. The main identified fuel efficiencies were based on second generation devices, including wheel covers, side skirts, roof fairings, and rounded trailer corners. The important findings of this work were; (i) the optimum curvature radius of the rounded trailer edges found to be 125 mm, with an arc length of 196.3 mm, (ii) aerodynamic drag reduction increases with dropping clearance of side skirts between wheels and ground, and (iii) aerodynamic drag reduction increases with an extension of front bumper towards the ground.

  7. Quantitative mass spectrometric analysis of glycoproteins combined with enrichment methods.

    Science.gov (United States)

    Ahn, Yeong Hee; Kim, Jin Young; Yoo, Jong Shin

    2015-01-01

    Mass spectrometry (MS) has been a core technology for high sensitive and high-throughput analysis of the enriched glycoproteome in aspects of quantitative assays as well as qualitative profiling of glycoproteins. Because it has been widely recognized that aberrant glycosylation in a glycoprotein may involve in progression of a certain disease, the development of efficient analysis tool for the aberrant glycoproteins is very important for deep understanding about pathological function of the glycoprotein and new biomarker development. This review first describes the protein glycosylation-targeting enrichment technologies mainly employing solid-phase extraction methods such as hydrizide-capturing, lectin-specific capturing, and affinity separation techniques based on porous graphitized carbon, hydrophilic interaction chromatography, or immobilized boronic acid. Second, MS-based quantitative analysis strategies coupled with the protein glycosylation-targeting enrichment technologies, by using a label-free MS, stable isotope-labeling, or targeted multiple reaction monitoring (MRM) MS, are summarized with recent published studies. © 2014 The Authors. Mass Spectrometry Reviews Published by Wiley Periodicals, Inc.

  8. Thermodynamic analysis of a novel integrated solar combined cycle

    International Nuclear Information System (INIS)

    Li, Yuanyuan; Yang, Yongping

    2014-01-01

    Highlights: • A novel ISCC scheme with two-stage DSG fields has been proposed and analyzed. • HRSG and steam turbine working parameters have been optimized to match the solar integration. • New scheme exhibits higher solar shares in the power output and solar-to-electricity efficiency. • Thermodynamic performances between new and reference systems have been investigated and compared. - Abstract: Integrated solar combined cycle (ISCC) systems have become more and more popular due to their high fuel and solar energy utilization efficiencies. Conventional ISCC systems with direct steam generation (DSG) have only one-stage solar input. A novel ISCC with DSG system has been proposed and analyzed in this paper. The new system consists two-stage solar input, which would significantly increase solar share in the total power output. Moreover, how and where solar energy is input into ISCC system would have impact on the solar and system overall efficiencies, which have been analyzed in the paper. It has been found that using solar heat to supply latent heat for vaporization of feedwater would be superior to that to be used for sensible heating purposes (e.g. Superheating steam). The study shows that: (1) producing both the high- and low-pressure saturated steam in the DSG trough collector could be an efficient way to improve process and system performance; (2) for a given live steam pressure, the optimum secondary and reheat steam conditions could be matched to reach the highest system thermal efficiency and net solar-to-electricity efficiency; (3) the net solar-to-electricity efficiency could reach up to 30% in the novel two-stage ISCC system, higher than that in the one-stage ISCC power plant; (4) compared with the conventional combined cycle gas turbine (CCGT) power system, lower stack temperature could be achieved, owing to the elimination of the approach-temperature-difference constraint, resulting in better thermal match in the heat recovery steam generator

  9. 78 FR 41804 - NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting.

    Science.gov (United States)

    2013-07-11

    ... following information no less than 10 working days prior to the meeting: Full name; gender; date/place of... meeting includes briefings on the following topics: Finance Update Strategy, Performance, Budget Update... affiliation 3 working days prior to the meeting to Angela Herring at (202) 358-1698 or fax (202) 358- 4336...

  10. Stochastic analysis of residential micro combined heat and power system

    International Nuclear Information System (INIS)

    Karami, H.; Sanjari, M.J.; Gooi, H.B.; Gharehpetian, G.B.; Guerrero, J.M.

    2017-01-01

    Highlights: • Applying colonial competitive algorithm to the problem of optimal dispatching. • Economic modeling of the residential integrated energy system. • Investigating differences of stand-alone and system-connected modes of fuel cell operation. • Considering uncertainty on the electrical load. • The effects of battery capacity and its efficiency on the system is investigated. - Abstract: In this paper the combined heat and power functionality of a fuel-cell in a residential hybrid energy system, including a battery, is studied. The demand uncertainties are modeled by investigating the stochastic load behavior by applying Monte Carlo simulation. The colonial competitive algorithm is adopted to the hybrid energy system scheduling problem and different energy resources are optimally scheduled to have optimal operating cost of hybrid energy system. In order to show the effectiveness of the colonial competitive algorithm, the results are compared with the results of the harmony search algorithm. The optimized scheduling of different energy resources is listed in an efficient look-up table for all time intervals. The effects of time of use and the battery efficiency and its size are investigated on the operating cost of the hybrid energy system. The results of this paper are expected to be used effectively in a real hybrid energy system.

  11. Combined analysis of fourteen nuclear genes refines the Ursidae phylogeny.

    Science.gov (United States)

    Pagès, Marie; Calvignac, Sébastien; Klein, Catherine; Paris, Mathilde; Hughes, Sandrine; Hänni, Catherine

    2008-04-01

    Despite numerous studies, questions remain about the evolutionary history of Ursidae and additional independent genetic markers were needed to elucidate these ambiguities. For this purpose, we sequenced ten nuclear genes for all the eight extant bear species. By combining these new sequences with those of four other recently published nuclear markers, we provide new insights into the phylogenetic relationships of the Ursidae family members. The hypothesis that the giant panda was the first species to diverge among ursids is definitively confirmed and the precise branching order within the Ursus genus is clarified for the first time. Moreover, our analyses indicate that the American and the Asiatic black bears do not cluster as sister taxa, as had been previously hypothesised. Sun and sloth bears clearly appear as the most basal ursine species but uncertainties about their exact relationships remain. Since our larger dataset did not enable us to clarify this last question, identifying rare genomic changes in bear genomes could be a promising solution for further studies.

  12. Impossible meet-in-the-middle fault analysis on the LED lightweight cipher in VANETs

    DEFF Research Database (Denmark)

    Li, Wei; Rijmen, Vincent; Tao, Zhi

    2018-01-01

    With the expansion of wireless technology, vehicular ad-hoc networks (VANETs) are emerging as a promising approach for realizing smart cities and addressing many serious traffic problems, such as road safety, convenience, and efficiency. To avoid any possible rancorous attacks, employing lightwei......With the expansion of wireless technology, vehicular ad-hoc networks (VANETs) are emerging as a promising approach for realizing smart cities and addressing many serious traffic problems, such as road safety, convenience, and efficiency. To avoid any possible rancorous attacks, employing....... A detailed analysis of the expected number of faults is used to uniquely determine the secret key. It is based on the propagation of truncated differentials and is surprisingly reminiscent of the computation of the complexity of a rectangle attack. It shows that the impossible meet-in-the-middle fault...

  13. Reliability analysis of HVDC grid combined with power flow simulations

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Yongtao; Langeland, Tore; Solvik, Johan [DNV AS, Hoevik (Norway); Stewart, Emma [DNV KEMA, Camino Ramon, CA (United States)

    2012-07-01

    Based on a DC grid power flow solver and the proposed GEIR, we carried out reliability analysis for a HVDC grid test system proposed by CIGRE working group B4-58, where the failure statistics are collected from literature survey. The proposed methodology is used to evaluate the impact of converter configuration on the overall reliability performance of the HVDC grid, where the symmetrical monopole configuration is compared with the bipole with metallic return wire configuration. The results quantify the improvement on reliability by using the later alternative. (orig.)

  14. Combined osteochondral allograft and meniscal allograft transplantation: a survivorship analysis.

    Science.gov (United States)

    Getgood, Alan; Gelber, Jonathon; Gortz, Simon; De Young, Alison; Bugbee, William

    2015-04-01

    The efficacy of meniscal allograft transplantation (MAT) and osteochondral allografting (OCA) as individual treatment modalities for select applications is well established. MAT and OCA are considered symbiotic procedures due to a complementary spectrum of indications and reciprocal contraindications. However, few outcomes of concomitant MAT and OCA have been reported. This study is a retrospective review of patients who received simultaneous MAT and OCA between 1983 and 2011. Forty-eight (twenty-nine male: nineteen female) patients with a median age of 35.8 years (15-66) received combined MAT and OCA procedures between 1983 and 2011. Forty-three patients had received previous surgery with a median of 3 procedures (1-11 procedures). The underlying diagnosis was trauma (tibial plateau fracture) in 33 % with osteoarthritis predominating in 54.2 % of cases. Thirty-one patients received a lateral meniscus, 16 received a medial meniscus and one patient received bilateral MAT. The median number of OCAs was two per patient (1-5 grafts), with a median graft area of 15 cm(2) (0.7-41 cm(2)). There were 21 unipolar, 24 bipolar (tibiofemoral) and three multifocal lesions. Thirty-six MATs constituted a compound tibial plateau OCA with native meniscus attached. At follow-up, failure was defined as any procedure resulting in removal or revision of one or more of the grafts. Patients completed the modified Merle d'Aubigné and Postel (18-point) scale, Knee Society Function (KS-F) score, and subjective International Knee Documentation Committee (IKDC) scores. Patient satisfaction was also captured. Twenty-six of 48 patients (54.2 %) required reoperation, but only 11 patients (22.9 %) were noted to have failed (10 MAT and 11 OCA). The mean time to failure was 3.2 years (95 % CI 1.5-4.9 years) and 2.7 years (95 % CI 1.3-4.2 years) for MAT and OCA, respectively. The 5-year survivorship was 78 and 73 % for MAT and OCA respectively, and 69 and 68 % at 10 years. Six of

  15. Video-tracker trajectory analysis: who meets whom, when and where

    Science.gov (United States)

    Jäger, U.; Willersinn, D.

    2010-04-01

    Unveiling unusual or hostile events by observing manifold moving persons in a crowd is a challenging task for human operators, especially when sitting in front of monitor walls for hours. Typically, hostile events are rare. Thus, due to tiredness and negligence the operator may miss important events. In such situations, an automatic alarming system is able to support the human operator. The system incorporates a processing chain consisting of (1) people tracking, (2) event detection, (3) data retrieval, and (4) display of relevant video sequence overlaid by highlighted regions of interest. In this paper we focus on the event detection stage of the processing chain mentioned above. In our case, the selected event of interest is the encounter of people. Although being based on a rather simple trajectory analysis, this kind of event embodies great practical importance because it paves the way to answer the question "who meets whom, when and where". This, in turn, forms the basis to detect potential situations where e.g. money, weapons, drugs etc. are handed over from one person to another in crowded environments like railway stations, airports or busy streets and places etc.. The input to the trajectory analysis comes from a multi-object video-based tracking system developed at IOSB which is able to track multiple individuals within a crowd in real-time [1]. From this we calculate the inter-distances between all persons on a frame-to-frame basis. We use a sequence of simple rules based on the individuals' kinematics to detect the event mentioned above to output the frame number, the persons' IDs from the tracker and the pixel coordinates of the meeting position. Using this information, a data retrieval system may extract the corresponding part of the recorded video image sequence and finally allows for replaying the selected video clip with a highlighted region of interest to attract the operator's attention for further visual inspection.

  16. Combined QCD and electroweak analysis of HERA data

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, H. [Tel Aviv Univ. (Israel). School of Physics; Max-Planck-Institute for Physics, Munich (Germany); Abt, I. [Max-Planck-Institute for Physics, Munich (Germany); Adamczyk, L. [AGH-Univ. of Science and Technology, Krakow (Poland). Faculty of Physics and Applied Computer Science; Collaboration: ZEUS Collaboration; and others

    2016-03-15

    A simultaneous fit of parton distribution functions (PDFs) and electroweak parameters to HERA data on deep inelastic scattering is presented. The input data are the neutral current and charged current inclusive cross sections which were previously used in the QCD analysis leading to the HERAPDF2.0 PDFs. In addition, the polarisation of the electron beam was taken into account for the ZEUS data recorded between 2004 and 2007. Results on the vector and axial-vector couplings of the Z boson to u- and d-type quarks, on the value of the electroweak mixing angle and the mass of the W boson are presented. The values obtained for the electroweak parameters are in agreement with Standard Model predictions.

  17. MAMMOGRAMS ANALYSIS USING SVM CLASSIFIER IN COMBINED TRANSFORMS DOMAIN

    Directory of Open Access Journals (Sweden)

    B.N. Prathibha

    2011-02-01

    Full Text Available Breast cancer is a primary cause of mortality and morbidity in women. Reports reveal that earlier the detection of abnormalities, better the improvement in survival. Digital mammograms are one of the most effective means for detecting possible breast anomalies at early stages. Digital mammograms supported with Computer Aided Diagnostic (CAD systems help the radiologists in taking reliable decisions. The proposed CAD system extracts wavelet features and spectral features for the better classification of mammograms. The Support Vector Machines classifier is used to analyze 206 mammogram images from Mias database pertaining to the severity of abnormality, i.e., benign and malign. The proposed system gives 93.14% accuracy for discrimination between normal-malign and 87.25% accuracy for normal-benign samples and 89.22% accuracy for benign-malign samples. The study reveals that features extracted in hybrid transform domain with SVM classifier proves to be a promising tool for analysis of mammograms.

  18. Combined QCD and electroweak analysis of HERA data

    International Nuclear Information System (INIS)

    Abramowicz, H.; Abt, I.; Adamczyk, L.

    2016-03-01

    A simultaneous fit of parton distribution functions (PDFs) and electroweak parameters to HERA data on deep inelastic scattering is presented. The input data are the neutral current and charged current inclusive cross sections which were previously used in the QCD analysis leading to the HERAPDF2.0 PDFs. In addition, the polarisation of the electron beam was taken into account for the ZEUS data recorded between 2004 and 2007. Results on the vector and axial-vector couplings of the Z boson to u- and d-type quarks, on the value of the electroweak mixing angle and the mass of the W boson are presented. The values obtained for the electroweak parameters are in agreement with Standard Model predictions.

  19. Combined QCD and electroweak analysis of HERA data

    CERN Document Server

    Abramowicz, H; Adamczyk, L; Adamus, M; Antonelli, S; Aushev, V; Behnke, O; Behrens, U; Bertolin, A; Bloch, I; Boos, EG; Brock, I; Brook, NH; Brugnera, R; Bruni, A; Bussey, PJ; Caldwell, A; Capua, M; Catterall, CD; Chwastowski, J; Ciborowski, J; Ciesielski, R; Cooper-Sarkar, AM; Corradi, M; Dementiev, RK; Devenish, RCE; Dusini, S; Foster, B; Gach, G; Gallo, E; Garfagnini, A; Geiser, A; Gizhko, A; Gladilin, LK; Golubkov, Yu A; Grzelak, G; Guzik, M; Hain, W; Hochman, D; Hori, R; Ibrahim, ZA; Iga, Y; Ishitsuka, M; Januschek, F; Jomhari, NZ; Kadenko, I; Kananov, S; Karshon, U; Kaur, P; Kisielewska, D; Klanner, R; Klein, U; Korzhavina, IA; Kotański, A; Kötz, U; Kovalchuk, N; Kowalski, H; Krupa, B; Kuprash, O; Kuze, M; Levchenko, BB; Levy, A; Limentani, S; Lisovyi, M; Lobodzinska, E; Löhr, B; Lohrmann, E; Longhin, A; Lontkovskyi, D; Lukina, OYu; Makarenko, I; Malka, J; Mohamad Idris, F; Mohammad Nasir, N; Myronenko, V; Nagano, K; Nobe, T; Nowak, RJ; Onishchuk, Yu; Paul, E; Perlański, W; Pokrovskiy, NS; Przybycien, M; Roloff, P; Ruspa, M; Saxon, DH; Schioppa, M; Schneekloth, U; Schörner-Sadenius, T; Shcheglova, LM; Shevchenko, R; Shkola, O; Shyrma, Yu; Singh, I; Skillicorn, IO; Słomiński, W; Solano, A; Stanco, L; Stefaniuk, N; Stern, A; Stopa, P; Sztuk-Dambietz, J; Tassi, E; Tokushuku, K; Tomaszewska, J; Tsurugai, T; Turcato, M; Turkot, O; Tymieniecka, T; Verbytskyi, A; Wan Abdullah, WAT; Wichmann, K; Wing, M; Yamada, S; Yamazaki, Y; Zakharchuk, N; Żarnecki, AF; Zawiejski, L; Zenaiev, O; Zhautykov, BO; Zotkin, DS; Bhadra, S; Gwenlan, C; Hlushchenko, O; Polini, A; Mastroberardino, A

    2016-05-03

    A simultaneous fit of parton distribution functions (PDFs) and electroweak parameters to HERA data on deep inelastic scattering is presented. The input data are the neutral current and charged current inclusive cross sections which were previously used in the QCD analysis leading to the HERAPDF2.0 PDFs. In addition, the polarisation of the electron beam was taken into account for the ZEUS data recorded between 2004 and 2007. Results on the vector and axial-vector couplings of the Z boson to u- and d-type quarks, on the value of the electroweak mixing angle and the mass of the W boson are presented. The values obtained for the electroweak parameters are in agreement with Standard Model predictions.

  20. Uses of Activation Analysis in Studies of Mineral Element Metabolism in Man. Papers Given at a Panel Meeting

    International Nuclear Information System (INIS)

    1970-01-01

    In June, 1968, the International Atomic Energy Agency held a panel meeting in Teheran, Iran, to discuss some of the uses of activation analysis in studies of mineral element metabolism in man. The aims of the meeting were to identify and draw attention to specific medical problems to which activation analysis could be fruitfully applied, to review the capabilities of the technique itself, and to recommend specific action which the Agency might take to support further work in this field. The scientific papers presented at the meeting have been gathered together in this report, and it is hoped that their publication will be of interest to all concerned with mineral element metabolism in man, whether studied by activation analysis or by other methods

  1. Throughput and Delay Analysis of HARQ with Code Combining over Double Rayleigh Fading Channels

    KAUST Repository

    Chelli, Ali

    2018-01-15

    This paper proposes the use of hybrid automatic repeat request (HARQ) with code combining (HARQ-CC) to offer reliable communications over double Rayleigh channels. The double Rayleigh fading channel is of particular interest to vehicle-to-vehicle communication systems as well as amplify-and-forward relaying and keyhole channels. This work studies the performance of HARQ-CC over double Rayleigh channels from an information theoretic perspective. Analytical approximations are derived for the $\\\\epsilon$-outage capacity, the average number of transmissions, and the throughput of HARQ-CC. Moreover, we evaluate the delay experienced by Poisson arriving packets for HARQ-CC. We provide analytical expressions for the average waiting time, the packets sojourn time, the average consumed power, and the energy efficiency. In our investigation, we take into account the impact of imperfect feedback on different performance metrics. Additionally, we explore the tradeoff between energy efficiency and the throughput. The proposed scheme is shown to maintain the outage probability below a specified threshold $\\\\epsilon$ which ensures the link reliability. Meanwhile, HARQ-CC adapts implicitly the transmission rate to the channel conditions such that the throughput is maximized. Our results demonstrate that HARQ-CC allows improving the achievable communication rate compared to fixed time diversity schemes. To maximize the throughput of HARQ-CC, the rate per HARQ round should be less than the rate required to meet the outage constraint. Our investigation of the performance of HARQ-CC over Rayleigh and double Rayleigh channels shows that double Rayleigh channels have a higher severity of fading and result in a larger degradation of the throughput. Our analysis reveals that HARQ with incremental redundancy (HARQ-IR) achieves a larger throughput compared to HARQ-CC, while HARQ-CC is simpler to implement, has a lower decoding

  2. Use of computational fluid dynamics codes for safety analysis of nuclear reactor systems, including containment. Summary report of a technical meeting

    International Nuclear Information System (INIS)

    2003-11-01

    Safety analysis is an important tool for justifying the safety of nuclear power plants. Typically, this type of analysis is performed by means of system computer codes with one dimensional approximation for modelling real plant systems. However, in the nuclear area there are issues for which traditional treatment using one dimensional system codes is considered inadequate for modelling local flow and heat transfer phenomena. There is therefore increasing interest in the application of three dimensional computational fluid dynamics (CFD) codes as a supplement to or in combination with system codes. There are a number of both commercial (general purpose) CFD codes as well as special codes for nuclear safety applications available. With further progress in safety analysis techniques, the increasing use of CFD codes for nuclear applications is expected. At present, the main objective with respect to CFD codes is generally to improve confidence in the available analysis tools and to achieve a more reliable approach to safety relevant issues. An exchange of views and experience can facilitate and speed up progress in the implementation of this objective. Both the International Atomic Energy Agency (IAEA) and the Nuclear Energy Agency of the Organisation for Economic Co-operation and Development (OECD/NEA) believed that it would be advantageous to provide a forum for such an exchange. Therefore, within the framework of the Working Group on the Analysis and Management of Accidents of the NEA's Committee on the Safety of Nuclear Installations, the IAEA and the NEA agreed to jointly organize the Technical Meeting on the Use of Computational Fluid Dynamics Codes for Safety Analysis of Reactor Systems, including Containment. The meeting was held in Pisa, Italy, from 11 to 14 November 2002. The publication constitutes the report of the Technical Meeting. It includes short summaries of the presentations that were made and of the discussions as well as conclusions and

  3. Use of research reactors for neutron activation analysis. Report of an advisory group meeting

    International Nuclear Information System (INIS)

    2001-04-01

    Neutron activation analysis (NAA) is an analytical technique based on the measurement of characteristic radiation from radionuclides formed directly or indirectly by neutron irradiation of the material of interest. In the last three decades, neutron activation analysis has been found to be extremely useful in the determination of trace and minor elements in many disciplines. These include environmental analysis applications, nutritional and health related studies, geological as well as material sciences. The most suitable source of neutrons for NAA is a research reactor. There are several application fields in which NAA has a superior position compared to other analytical methods, and there are good prospects in developing countries for long term growth. Therefore, the IAEA is making concerted efforts to promote neutron activation analysis and at the same time to assist developing Member States in better utilization of their research reactors. The purpose of the meeting was to discuss the benefits and the role of NAA in applications and research areas that may contribute towards improving utilization of research reactors. The participants focused on five specific topics: (1) Current trends in NAA; (2) The role of NAA compared to other methods of chemical analysis; (3) How to increase the number of NAA users through interaction with industries, research institutes, universities and medical institutions; (4) How to reduce costs and to maintain quality and reliability; (5) NAA using low power research reactors. Neutron activation analysis in its various forms is still active and there are good prospects in developing countries for long-term growth. This can be achieved by a more effective use of existing irradiation and counting facilities, a better end-user focus, and perhaps marginal improvements in equipment and techniques. Therefore, it is recommended that the Member States provide financial and other assistance to enhance the effectiveness of their laboratories

  4. [A therapeutic effect analysis of femur first principle and combined anteversion technique during total hip arthroplasty].

    Science.gov (United States)

    Wang, X Q; Wu, C S; Sun, S; Wang, J; Li, W; Zhang, W

    2018-04-01

    Objective: To investigate the situation of hip dislocation with the application of "femur first" principle and "combined anteversion technique" during total hip arthroplasty. Methods: A retrospective analysis has been done on the clinical data about 104 patients(133 hips)who were diagnosed as hip disease and were treated with total hip arthroplasty by the doctors from the Department of Joint Orthorpaedics of Shandong Provincial Hospital Affiliated to Shandong University from June 2014 to June 2016, and all the prostheses applied in the operation were cementless ones.Among them, 65 patients were males, 39 females and their age was 46.6 years (ranging from 23 to 76 years) .And 29 of them underwent bilateral hip operations and 75 unilateral ones.Seventy-six cases of aseptic necrosis of the femoral head in the terminal stage, 28 cases of hip dysplasia and osteoarthritis.Surgical approach: of all the operations, 103 hips were operated on with hardinge approach, 30 with posterolateral approach.During the operation, first of all, the femoral medullary cavity was broached and then the anteversion of intramedullary broacher was measured.After that, the anteversion of the acetabular cup was calculated as 37° minus the anteversion of the broacher, and the acetabular cup was implanted at that angle.The patients' prosthesis combined anteversion, range of motion of the hip joint, operation time, hemorrhage amount, and complications had been kept record.One, three, and six months respectively after the operation, all the patients received outpatient review, and took anteroposterior and lateral position X-ray examination.Harris hip score had been applied to evaluate their hip function before the operation and six months after the operation. Results: All the patients had been operated on smoothly, with the operation time of(57.6±14.5)minutes(36-115 minutes)and hemorrhage amount of (336.5±50.8)ml(180-620 ml). The operation finding showed that the combined anteversion by employing

  5. Progress in the Full-Text Publication Rate of Orthopaedic and Sport Physical Therapy Abstracts Presented at the American Physical Therapy Association's Combined Sections Meeting.

    Science.gov (United States)

    Warden, Stuart J; Fletcher, Jacquelyn M; Barker, Rick G; Guildenbecher, Elizabeth A; Gorkis, Colleen E; Thompson, William R

    2017-10-07

    Study Design Descriptive study. Background Professional meetings, such as the American Physical Therapy Association's (APTA's) Combined Sections Meeting (CSM), provide forums for sharing information. However, it was reported that only one-quarter of orthopaedic and sports physical therapy abstracts presented at the CSM between 2000 and 2004 went on to full-text publication. This low conversion rate raises a number of concerns regarding the full dissemination of work within the profession. Objectives The purpose of this study was to determine the full-text publication rate of work presented in abstract form at subsequent CSMs and investigate factors influencing the rate. Methods A systematic search was undertaken to locate full-text publications of orthopaedic and sports physical therapy abstracts presented at CSMs between 2005 and 2011. Eligible publications were published within 5 years following abstract presentation. The influences of year of abstract presentation, APTA section, presentation type, institution of origin, study design, and study significance were assessed. Results Over one-third (38.6%) of presented abstracts progressed to full-text publication. Odds of full-text publication increased if the abstract was presented as a platform presentation, originated from a doctorate-granting institution, reported findings of an experimental study, or reported a statistically significant finding. Conclusion The full-text publication rate for orthopaedic and sports physical therapy abstracts presented at recent CSMs has increased by over 50% compared to that reported for the preceding period. The rate is now in the range of that reported in comparable clinical disciplines, demonstrating important progress in the full dissemination of work within the profession. J Orthop Sports Phys Ther, Epub 7 Oct 2017. doi:10.2519/jospt.2018.7581.

  6. A hybrid sales forecasting scheme by combining independent component analysis with K-means clustering and support vector regression.

    Science.gov (United States)

    Lu, Chi-Jie; Chang, Chi-Chang

    2014-01-01

    Sales forecasting plays an important role in operating a business since it can be used to determine the required inventory level to meet consumer demand and avoid the problem of under/overstocking. Improving the accuracy of sales forecasting has become an important issue of operating a business. This study proposes a hybrid sales forecasting scheme by combining independent component analysis (ICA) with K-means clustering and support vector regression (SVR). The proposed scheme first uses the ICA to extract hidden information from the observed sales data. The extracted features are then applied to K-means algorithm for clustering the sales data into several disjoined clusters. Finally, the SVR forecasting models are applied to each group to generate final forecasting results. Experimental results from information technology (IT) product agent sales data reveal that the proposed sales forecasting scheme outperforms the three comparison models and hence provides an efficient alternative for sales forecasting.

  7. Dynamic analysis of combined photovoltaic source and synchronous generator connected to power grid

    Science.gov (United States)

    Mahabal, Divya

    In the world of expanding economy and technology, the energy demand is likely to increase even with the global efforts of saving and increasing energy efficiency. Higher oil prices, effects of greenhouse gases, and concerns over other environmental impacts gave way to Distributed Generation (DG). With adequate awareness and support, DG's can meet these rising energy demands at lower prices compared to conventional methods. Extensive research is taking place in different areas like fuel cells, photovoltaic cells, wind turbines, and gas turbines. DG's when connected to a grid increase the overall efficiency of the power grid. It is believed that three-fifth of the world's electricity would account for renewable energy by middle of 21st century. This thesis presents the dynamic analysis of a grid connected photovoltaic (PV) system and synchronous generator. A grid is considered as an infinite bus. The photovol-taic system and synchronous generator act as small scale distributed energy resources. The output of the photovoltaic system depends on the light intensity, temperature, and irradiance levels of sun. The maximum power point tracking and DC/AC converter are also modeled for the photovoltaic system. The PV system is connected to the grid through DC/AC system. Different combinations of PV and synchronous generator are modeled with the grid to study the dynamics of the proposed system. The dynamics of the test system is analyzed by subjecting the system to several disturbances under various conditions. All modules are individually modeled and con-nected using MATLAB/Simulink software package. Results from the study show that, as the penetration of renewable energy sources like PV increases into the power system, the dynamics of the system becomes faster. When considering cases such as load switching, PV cannot deliver more power as the performance of PV depends on environmental conditions. Synchronous generator in power system can produce the required amount of

  8. Aligning experimental design with bioinformatics analysis to meet discovery research objectives.

    Science.gov (United States)

    Kane, Michael D

    2002-01-01

    The utility of genomic technology and bioinformatic analytical support to provide new and needed insight into the molecular basis of disease, development, and diversity continues to grow as more research model systems and populations are investigated. Yet deriving results that meet a specific set of research objectives requires aligning or coordinating the design of the experiment, the laboratory techniques, and the data analysis. The following paragraphs describe several important interdependent factors that need to be considered to generate high quality data from the microarray platform. These factors include aligning oligonucleotide probe design with the sample labeling strategy if oligonucleotide probes are employed, recognizing that compromises are inherent in different sample procurement methods, normalizing 2-color microarray raw data, and distinguishing the difference between gene clustering and sample clustering. These factors do not represent an exhaustive list of technical variables in microarray-based research, but this list highlights those variables that span both experimental execution and data analysis. Copyright 2001 Wiley-Liss, Inc.

  9. Challenges in combining different data sets during analysis when using grounded theory.

    Science.gov (United States)

    Rintala, Tuula-Maria; Paavilainen, Eija; Astedt-Kurki, Päivi

    2014-05-01

    To describe the challenges in combining two data sets during grounded theory analysis. The use of grounded theory in nursing research is common. It is a suitable method for studying human action and interaction. It is recommended that many alternative sources of data are collected to create as rich a dataset as possible. Data from interviews with people with diabetes (n=19) and their family members (n=19). Combining two data sets. When using grounded theory, there are numerous challenges in collecting and managing data, especially for the novice researcher. One challenge is to combine different data sets during the analysis. There are many methodological textbooks about grounded theory but there is little written in the literature about combining different data sets. Discussion is needed on the management of data and the challenges of grounded theory. This article provides a means for combining different data sets in the grounded theory analysis process.

  10. Combined approach based on principal component analysis and canonical discriminant analysis for investigating hyperspectral plant response

    Directory of Open Access Journals (Sweden)

    Anna Maria Stellacci

    2012-07-01

    Full Text Available Hyperspectral (HS data represents an extremely powerful means for rapidly detecting crop stress and then aiding in the rational management of natural resources in agriculture. However, large volume of data poses a challenge for data processing and extracting crucial information. Multivariate statistical techniques can play a key role in the analysis of HS data, as they may allow to both eliminate redundant information and identify synthetic indices which maximize differences among levels of stress. In this paper we propose an integrated approach, based on the combined use of Principal Component Analysis (PCA and Canonical Discriminant Analysis (CDA, to investigate HS plant response and discriminate plant status. The approach was preliminary evaluated on a data set collected on durum wheat plants grown under different nitrogen (N stress levels. Hyperspectral measurements were performed at anthesis through a high resolution field spectroradiometer, ASD FieldSpec HandHeld, covering the 325-1075 nm region. Reflectance data were first restricted to the interval 510-1000 nm and then divided into five bands of the electromagnetic spectrum [green: 510-580 nm; yellow: 581-630 nm; red: 631-690 nm; red-edge: 705-770 nm; near-infrared (NIR: 771-1000 nm]. PCA was applied to each spectral interval. CDA was performed on the extracted components to identify the factors maximizing the differences among plants fertilised with increasing N rates. Within the intervals of green, yellow and red only the first principal component (PC had an eigenvalue greater than 1 and explained more than 95% of total variance; within the ranges of red-edge and NIR, the first two PCs had an eigenvalue higher than 1. Two canonical variables explained cumulatively more than 81% of total variance and the first was able to discriminate wheat plants differently fertilised, as confirmed also by the significant correlation with aboveground biomass and grain yield parameters. The combined

  11. Comet Methy-sens and DNMTs transcriptional analysis as a combined approach in epigenotoxicology

    Directory of Open Access Journals (Sweden)

    Alessio Perotti

    2015-05-01

    In conclusion, our data demonstrate that Comet Methy-sens, in combination with the analysis of transcriptional levels of DNA methyl transferases, represents a simple and multifunctional approach to implement biomonitoring studies on epigenotoxicological effects of known and unknown xenobiotics.

  12. The Assessment of a Tutoring Program to Meet CAS Standards Using a SWOT Analysis and Action Plan

    Science.gov (United States)

    Fullmer, Patricia

    2009-01-01

    This article summarizes the use of SWOT (Strengths, Weaknesses, Opportunities, and Threats) analysis and subsequent action planning as a tool of self-assessment to meet CAS (Council for the Advancement of Standards in Higher Education) requirements for systematic assessment. The use of the evaluation results to devise improvements to increase the…

  13. 75 FR 17437 - NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting

    Science.gov (United States)

    2010-04-06

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-040)] NASA Advisory Council; Audit... amended, the National Aeronautics and Space Administration announces a meeting of the Audit, Finance and... topic: GAO High Risk List The meeting will be open to the public up to the seating capacity of the room...

  14. Identification of drug combinations administered by continuous subcutaneous infusion that require analysis for compatibility and stability.

    Science.gov (United States)

    Dickman, Andrew; Bickerstaff, Matthew; Jackson, Richard; Schneider, Jennifer; Mason, Stephen; Ellershaw, John

    2017-03-23

    A continuous subcutaneous infusion (CSCI) delivered via syringe pump is a method of drug administration used to maintain symptom control when a patient is no longer able to tolerate oral medication. Several classes of drugs, such as opioids, antiemetics, anticholinergics, antipsychotics and benzodiazepines are routinely administered by CSCI alone or in combinations. Previous studies attempting to identify the most-common CSCI combinations are now several years old and no longer reflect current clinical practice. The aim of this work was to review current clinical practice and identify CSCI drug combinations requiring analysis for chemical compatibility and stability. UK pharmacy professionals involved in the delivery of care to palliative patients in hospitals and hospices were invited to enter CSCI combinations comprised of two or more drugs onto an electronic database over a 12-month period. In addition, a separate Delphi study with a panel of 15 expert healthcare professionals was completed to identify a maximum of five combinations of drugs used to treat more complex, but less commonly encountered symptoms unlikely to be identified by the national survey. A total of 57 individuals representing 33 separate palliative care services entered 1,945 drug combinations suitable for analysis, with 278 discrete combinations identified. The top 40 drug combinations represented nearly two-thirds of combinations recorded. A total of 23 different drugs were administered in combination and the median number of drugs in a combination was three. The Delphi study identified five combinations for the relief of complex or refractory symptoms. This study represents the first step towards developing authoritative national guidance on the administration of drugs by CSCI. Further work will ensure healthcare practitioners have the knowledge and confidence that a prescribed combination will be both safe and efficacious.

  15. BE-2004: International meeting on updates in best estimate methods in nuclear installation safety analysis. Proceedings

    International Nuclear Information System (INIS)

    2004-01-01

    BE-2004 is the second in a series of embedded conferences that focus on generating and sustaining the dialogue regarding the use of best estimate plus uncertainty tools to license operational and advanced nuclear systems. The first conference in the series was held during the 2000 American Nuclear Society Winter Meeting in Washington. BE-2004 is international in scope, as evidenced by the multinational sources of the papers, and is intended to serve as an opportunity for information exchange between research scientists, practicing engineers, and regulators. However, as appropriate to a follow-on conference, the primary theme of BE-2004 is to provide updates reflecting the progress in best estimate methodologies in the last four years. Examples include research activities that evolved from the current Generation-IV initiative and other new designs [Nuclear Energy Research Initiative (NERI), etc.], core design and neutronic calculations that support best estimate analysis, use of advanced methodologies to produce plant licensing procedures competitive with best estimate methods, and of course current philosophical and technical issues that need to be considered in implementing best estimate codes as an established part of the international licensing framework

  16. Proceedings of DAE-BRNS discussion meet on current trends and future perspectives of neutron activation analysis

    International Nuclear Information System (INIS)

    Reddy, A.V.R.; Acharya, R.; Nair, A.G.C.; Manchanda, V.K.

    2006-01-01

    The theme of the meet includes: Development of Neutron Activation Analysis (Naca) methods : k o -based NAA, Chemical NAA, Short-lived NAA, Prompt Gamma ray NAA (PGNAA), Fast neutron NAA using reactor and 14 MeV neutrons, Applications of NAA methods in various fields, Gamma ray spectrometry, An in-sight to data analysis in NAA, Position of NAA in comparison to other Nuclear Analytical Techniques (NATs) and Future perspectives in a panel discussion. Papers relevant to INIS are indexed separately

  17. A general model for preload calculation and stiffness analysis for combined angular contact ball bearings

    Science.gov (United States)

    Zhang, Jinhua; Fang, Bin; Hong, Jun; Wan, Shaoke; Zhu, Yongsheng

    2017-12-01

    The combined angular contact ball bearings are widely used in automatic, aerospace and machine tools, but few researches on the combined angular contact ball bearings have been reported. It is shown that the preload and stiffness of combined bearings are mutual influenced rather than simply the superposition of multiple single bearing, therefore the characteristic calculation of combined bearings achieved by coupling the load and deformation analysis of a single bearing. In this paper, based on the Jones quasi-static model and stiffness analytical model, a new iterative algorithm and model are proposed for the calculation of combined bearings preload and stiffness, and the dynamic effects include centrifugal force and gyroscopic moment have to be considered. It is demonstrated that the new method has general applicability, the preload factors of combined bearings are calculated according to the different design preloads, and the static and dynamic stiffness for various arrangements of combined bearings are comparatively studied and analyzed, and the influences of the design preload magnitude, axial load and rotating speed are discussed in detail. Besides, the change rule of dynamic contact angles of combined bearings with respect to the rotating speed is also discussed. The results show that bearing arrangement modes, rotating speed and design preload magnitude have a significant influence on the preload and stiffness of combined bearings. The proposed formulation provides a useful tool in dynamic analysis of the complex bearing-rotor system.

  18. Combining real-time monitoring and knowledge-based analysis in MARVEL

    Science.gov (United States)

    Schwuttke, Ursula M.; Quan, A. G.; Angelino, R.; Veregge, J. R.

    1993-01-01

    Real-time artificial intelligence is gaining increasing attention for applications in which conventional software methods are unable to meet technology needs. One such application area is the monitoring and analysis of complex systems. MARVEL, a distributed monitoring and analysis tool with multiple expert systems, was developed and successfully applied to the automation of interplanetary spacecraft operations at NASA's Jet Propulsion Laboratory. MARVEL implementation and verification approaches, the MARVEL architecture, and the specific benefits that were realized by using MARVEL in operations are described.

  19. Meeting new challenges in radon measurements service with solid state alpha track analysis

    International Nuclear Information System (INIS)

    Calamosca, M.; Penzo, S.; Mustapha, A.O.

    2005-01-01

    Full text: The national and international legislation on the control of exposures to radiation now covers exposures to the naturally occurring radioactive materials (NORM), with particular emphasis on radon in workplaces. Consequently, many more working environments have now been brought to the realm of radiation monitoring. This is mirrored by a corresponding increase in the demands for radon monitoring service. The new challenges occasioned by the increase in demands are illustrated in this paper. The paper also describes the new integrated radon measurement system at the ENEA ION-IRP radon-in-air testing laboratory, designed to meet the new challenges. In this presentation emphasis is laid only on the special features, hardware and software, of the measurement system that directly result in enhancement of the overall throughput and the quality of the radon service. In addition the use of a new technique based on a numerical filtering of the main physical parameters of the alpha track analysis used to determine the radon exposure with a CR-39 detector is presented, with particular emphasis to the quality improvements of the measurement. The readout procedure adopted by the Enea radon Service is based on track analysis by light microscopy. Since the dimensions of the tracks are significantly affected by the light intensity, the illumination of the field of view (FOV) has to be as homogeneous as possible, in order to avoid sensitivity dependence on track position in the FOV. The lighting variation could be severe, especially at the borders or when a rectangular FOV is used. The coefficient of variation of the FOV light uniformity has to be periodically checked to maintain the variation below an acceptable limit, whereas if the results exceed this value a remedial action is mandatory. The numerical correction procedure here presented results effective. (author)

  20. Optimum design and thermodynamic analysis of a gas turbine and ORC combined cycle with recuperators

    International Nuclear Information System (INIS)

    Cao, Yue; Gao, Yike; Zheng, Ya; Dai, Yiping

    2016-01-01

    Highlights: • A GT-ORC combined cycle with recuperators was designed. • The effect of the ORC turbine inlet pressure on the combined cycle was examined. • Toluene was a more suitable working fluid for the GT-ORC combined cycle. • The GT-ORC combined cycle performed better than the GT-Rankine combined cycle. • The sensitivity analysis to the ambient temperature was completed. - Abstract: Gas turbines are widely used in distributed power generation because of their high efficiency, low pollution and low operational cost. To further utilize the waste heat from gas turbines, an organic Rankine cycle (ORC) was proposed as the bottoming cycle for gas turbines in this paper. Two recuperators were coupled with the combined cycle to increase the thermal efficiency, and aromatics were chosen as the working fluid for the bottoming cycle. This paper focused on the optimum design and thermodynamic analysis of the gas turbine and ORC (GT-ORC) combined cycle. Results showed that the net power and thermal efficiency of the ORC increased with the ORC turbine inlet pressure and achieved optimum values at a specific pressure based on the optimum criteria. Furthermore, compared with the GT-Rankine combined cycle, the GT-ORC combined cycle had better thermodynamic performance. Toluene was a more suitable working fluid for the GT-ORC combined cycle. Moreover, ambient temperature sensitivity simulations concluded that the GT-ORC combined cycle had a maximum thermal efficiency and the combined cycle net power was mainly determined by the topping gas turbine cycle.

  1. Examining Combinations of Social Physique Anxiety and Motivation Regulations Using Latent Profile Analysis

    Science.gov (United States)

    Ullrich-French, Sarah; Cox, Anne E.; Cooper, Brittany Rhoades

    2016-01-01

    Previous research has used cluster analysis to examine how social physique anxiety (SPA) combines with motivation in physical education. This study utilized a more advanced analytic approach, latent profile analysis (LPA), to identify profiles of SPA and motivation regulations. Students in grades 9-12 (N = 298) completed questionnaires at two time…

  2. Thermo-economic analysis of combined power plants with changing economic parameters

    International Nuclear Information System (INIS)

    Bidini, G.; Desideri, U.; Facchini, B.

    1991-01-01

    A method of thermo-economic analysis for the choice of optimal thermodynamic parameters of steam bottoming cycles in combined cycle power plants is presented. By keeping the thermodynamic aspects separated from the economic aspects, this method allows designers to easily perform a sensitivity analysis of the change in the economic parameters

  3. Use of PSA Level 2 analysis for improving containment performance. Report of a technical committee meeting

    International Nuclear Information System (INIS)

    1998-03-01

    In order to discuss and exchange experience on different aspects of methods associated with Level 2 PSA and its applications for improving containment performance, the IAEA held a Technical Committee meeting in Vienna in December 1996. The meeting, which was attended by 26 participants from 20 Member States, provided a broad forum for discussion. The meeting addressed the issues related to the actual performance of Level 2 PSA studies as well as the insights gained from applications to improve containment performance. Particular attention was given to studies and applications for WWER type reactors, for which Level 2 work is still in its early stages, and for channel type reactors where modelling of accident progression is complex and significantly different from vessel type light water reactors. This TECDOC contains the papers presented at the meeting and the results of extensive discussions which were held in specific working groups

  4. 75 FR 41240 - NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting.

    Science.gov (United States)

    2010-07-15

    ... amended, the National Aeronautics and Space Administration announces a meeting of the Audit, Finance and... building (West Lobby-- Visitor Control Center), and must state that they are attending the Audit, Finance...

  5. Identification and analysis of external event combinations for Hanhikivi 1PRA

    Energy Technology Data Exchange (ETDEWEB)

    Helander, Juho [Fennovoima Oy, Helsinki (Finland)

    2017-03-15

    Fennovoima's nuclear power plant, Hanhikivi 1, Pyhäjoki, Finland, is currently in design phase, and its construction is scheduled to begin in 2018 and electricity production in 2024. The objective of this paper is to produce a preliminary list of safety-significant external event combinations including preliminary probability estimates, to be used in the probabilistic risk assessment of Hanhikivi 1 plant. Starting from the list of relevant single events, the relevant event combinations are identified based on seasonal variation, preconditions related to different events, and dependencies (fundamental and cascade type) between events. Using this method yields 30 relevant event combinations of two events for the Hanhikivi site. The preliminary probability of each combination is evaluated, and event combinations with extremely low probability are excluded from further analysis. Event combinations of three or more events are identified by adding possible events to the remaining combinations of two events. Finally, 10 relevant combinations of two events and three relevant combinations of three events remain. The results shall be considered preliminary and will be updated after evaluating more detailed effects of different events on plant safety.

  6. Finishing and Special Motifs: Lessons Learned from CRISPR Analysis Using Next-Generation Draft Sequences (7th Annual SFAF Meeting, 2012)

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, Catherine

    2012-06-01

    Catherine Campbell on "Finishing and Special Motifs: Lessons learned from CRISPR analysis using next-generation draft sequences" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  7. Validation of a dissolution method with RP-HPLC analysis for Perindopril erbumine and Indapamide combination tablet

    Directory of Open Access Journals (Sweden)

    Jain P.S.

    2012-01-01

    Full Text Available A Dissolution method with high performance liquid chromatography (HPLC analysis was validated for perindopril erbumine and indapamide in combination tablet formulation. The method was validated to meet requirements for a global regulatory filing and this validation included specificity, linearity, accuracy, precision, range, robustness and solution stability studies. The dissolution method, which uses USP apparatus 1 with basket rotating at 100 rpm, 1000 ml of phosphate buffer pH 6.8 as the dissolution medium, and reversed-phased HPLC was carried out at 50⁰C on a 4.6mm×250mm 5μm cyano column that contained USP packing L1 with acetonitrile: buffer pH 2.8::40:60 (v/v, as mobile phase. UV detector was set at 225 nm. A method was found to be selective, linear, accurate and precise in the specified ranges. Intra-day and inter-day variability for method was <2% RSD. This method was successfully used for quantification of perindopril erbumine and indapamide combination tablet formulations.

  8. Parametric analysis and optimization for a combined power and refrigeration cycle

    International Nuclear Information System (INIS)

    Wang Jiangfeng; Dai Yiping; Gao Lin

    2008-01-01

    A combined power and refrigeration cycle is proposed, which combines the Rankine cycle and the absorption refrigeration cycle. This combined cycle uses a binary ammonia-water mixture as the working fluid and produces both power output and refrigeration output simultaneously with only one heat source. A parametric analysis is conducted to evaluate the effects of thermodynamic parameters on the performance of the combined cycle. It is shown that heat source temperature, environment temperature, refrigeration temperature, turbine inlet pressure, turbine inlet temperature, and basic solution ammonia concentration have significant effects on the net power output, refrigeration output and exergy efficiency of the combined cycle. A parameter optimization is achieved by means of genetic algorithm to reach the maximum exergy efficiency. The optimized exergy efficiency is 43.06% under the given condition

  9. Parametric analysis for a new combined power and ejector-absorption refrigeration cycle

    International Nuclear Information System (INIS)

    Wang Jiangfeng; Dai Yiping; Zhang Taiyong; Ma Shaolin

    2009-01-01

    A new combined power and ejector-absorption refrigeration cycle is proposed, which combines the Rankine cycle and the ejector-absorption refrigeration cycle, and could produce both power output and refrigeration output simultaneously. This combined cycle, which originates from the cycle proposed by authors previously, introduces an ejector between the rectifier and the condenser, and provides a performance improvement without greatly increasing the complexity of the system. A parametric analysis is conducted to evaluate the effects of the key thermodynamic parameters on the cycle performance. It is shown that heat source temperature, condenser temperature, evaporator temperature, turbine inlet pressure, turbine inlet temperature, and basic solution ammonia concentration have significant effects on the net power output, refrigeration output and exergy efficiency of the combined cycle. It is evident that the ejector can improve the performance of the combined cycle proposed by authors previously.

  10. A unified MGF-based capacity analysis of diversity combiners over generalized fading channels

    KAUST Repository

    Yilmaz, Ferkan

    2012-03-01

    Unified exact ergodic capacity results for L-branch coherent diversity combiners including equal-gain combining (EGC) and maximal-ratio combining (MRC) are not known. This paper develops a novel generic framework for the capacity analysis of L-branch EGC/MRC over generalized fading channels. The framework is used to derive new results for the gamma-shadowed generalized Nakagami-m fading model which can be a suitable model for the fading environments encountered by high frequency (60 GHz and above) communications. The mathematical formalism is illustrated with some selected numerical and simulation results confirming the correctness of our newly proposed framework. © 2012 IEEE.

  11. Comparative performance analysis of combined-cycle pulse detonation turbofan engines (PDTEs

    Directory of Open Access Journals (Sweden)

    Sudip Bhattrai

    2013-09-01

    Full Text Available Combined-cycle pulse detonation engines are promising contenders for hypersonic propulsion systems. In the present study, design and propulsive performance analysis of combined-cycle pulse detonation turbofan engines (PDTEs is presented. Analysis is done with respect to Mach number at two consecutive modes of operation: (1 Combined-cycle PDTE using a pulse detonation afterburner mode (PDA-mode and (2 combined-cycle PDTE in pulse detonation ramjet engine mode (PDRE-mode. The performance of combined-cycle PDTEs is compared with baseline afterburning turbofan and ramjet engines. The comparison of afterburning modes is done for Mach numbers from 0 to 3 at 15.24 km altitude conditions, while that of pulse detonation ramjet engine (PDRE is done for Mach 1.5 to Mach 6 at 18.3 km altitude conditions. The analysis shows that the propulsive performance of a turbine engine can be greatly improved by replacing the conventional afterburner with a pulse detonation afterburner (PDA. The PDRE also outperforms its ramjet counterpart at all flight conditions considered herein. The gains obtained are outstanding for both the combined-cycle PDTE modes compared to baseline turbofan and ramjet engines.

  12. PREFACE: Proceedings of the 2008 Numerical Relativity Data Analysis Meeting, Syracuse University, Syracuse, NY, USA, 11-14 August 2008 Proceedings of the 2008 Numerical Relativity Data Analysis Meeting, Syracuse University, Syracuse, NY, USA, 11-14 August 2008

    Science.gov (United States)

    Sutton, Patrick; Shoemaker, Deirdre

    2009-06-01

    The 2008 Numerical Relativity Data Analysis (NRDA) Meeting, the second in the series, was hosted by the Department of Physics at Syracuse University, 11-14 August 2008 with 60 participants. The purpose of the NRDA meetings is to bring together two communities with a vested interest in gravitational-wave observations: the data analysis and numerical relativity communities. The first NRDA meeting was held in November 2006 at MIT. A quote of Peter Saulson's from the Matters of Gravity Newsletter puts the importance of the NRDA meetings in perspective. He wrote: `As I sat in the back row of Rm NW14-1112 at MIT on Tuesday 7 November 2006, it suddenly struck me that we were participating in a watershed moment in the history of gravitational physics. Here, in the same room, were two communities who decades earlier had promised to help each other in a grand adventure: the detection of gravitational waves and the use of those waves to explore the frontiers of strong field gravity.' That meeting marked the first time when the two communities began to speak each other's language. By the time of the second NRDA meeting, much progress had been made. Numerical relativists were starting to explore the binary-black-hole parameter space and were making advances in evolutions of neutron-star and neutron-star/black-hole binaries. Data analysts were investigating better algorithms for the detection of both inspiral and burst sources. Most importantly, on 14 August 2008, someone sitting in the back row of the Stolkin Auditorium in Syracuse University might have noted the beginning of real collaborations between the two communities. The meeting included presentations based on joint work by numerical relativists and data analysts. Also the participants at NRDA2008 asked tough questions about how to best use numerical relativity in gravitational wave detection, as well as showcasing some of the science that will allow us to formulate the answers to these questions. This issue presents

  13. Eating or meeting? Cluster analysis reveals intricacies of white shark (Carcharodon carcharias migration and offshore behavior.

    Directory of Open Access Journals (Sweden)

    Salvador J Jorgensen

    Full Text Available Elucidating how mobile ocean predators utilize the pelagic environment is vital to understanding the dynamics of oceanic species and ecosystems. Pop-up archival transmitting (PAT tags have emerged as an important tool to describe animal migrations in oceanic environments where direct observation is not feasible. Available PAT tag data, however, are for the most part limited to geographic position, swimming depth and environmental temperature, making effective behavioral observation challenging. However, novel analysis approaches have the potential to extend the interpretive power of these limited observations. Here we developed an approach based on clustering analysis of PAT daily time-at-depth histogram records to distinguish behavioral modes in white sharks (Carcharodon carcharias. We found four dominant and distinctive behavioral clusters matching previously described behavioral patterns, including two distinctive offshore diving modes. Once validated, we mapped behavior mode occurrence in space and time. Our results demonstrate spatial, temporal and sex-based structure in the diving behavior of white sharks in the northeastern Pacific previously unrecognized including behavioral and migratory patterns resembling those of species with lek mating systems. We discuss our findings, in combination with available life history and environmental data, and propose specific testable hypotheses to distinguish between mating and foraging in northeastern Pacific white sharks that can provide a framework for future work. Our methodology can be applied to similar datasets from other species to further define behaviors during unobservable phases.

  14. Cardiac arrhythmia detection using combination of heart rate variability analyses and PUCK analysis.

    Science.gov (United States)

    Mahananto, Faizal; Igasaki, Tomohiko; Murayama, Nobuki

    2013-01-01

    This paper presents cardiac arrhythmia detection using the combination of a heart rate variability (HRV) analysis and a "potential of unbalanced complex kinetics" (PUCK) analysis. Detection performance was improved by adding features extracted from the PUCK analysis. Initially, R-R interval data were extracted from the original electrocardiogram (ECG) recordings and were cut into small segments and marked as either normal or arrhythmia. HRV analyses then were conducted using the segmented R-R interval data, including a time-domain analysis, frequency-domain analysis, and nonlinear analysis. In addition to the HRV analysis, PUCK analysis, which has been implemented successfully in a foreign exchange market series to characterize change, was employed. A decision-tree algorithm was applied to all of the obtained features for classification. The proposed method was tested using the MIT-BIH arrhythmia database and had an overall classification accuracy of 91.73%. After combining features obtained from the PUCK analysis, the overall accuracy increased to 92.91%. Therefore, we suggest that the use of a PUCK analysis in conjunction with HRV analysis might improve performance accuracy for the detection of cardiac arrhythmia.

  15. Development of a database for prompt γ-ray neutron activation analysis: Summary report of the third research coordination meeting

    International Nuclear Information System (INIS)

    Lindstrom, Richard M.; Firestone, Richard B.; Paviotti-Corcuera, R.

    2003-01-01

    The main discussions and conclusions from the Third Co-ordination Meeting on the Development of a Database for Prompt Gamma-ray Neutron Activation Analysis are summarized in this report. All results were reviewed in detail, and the final version of the TECDOC and the corresponding software were agreed upon and approved for preparation. Actions were formulated with the aim of completing the final version of the TECDOC and associated software by May 2003

  16. Development of a database for prompt γ-ray neutron activation analysis. Summary report of the third research coordination meeting

    International Nuclear Information System (INIS)

    Lindstorm, Richard M.; Firestone, Richard B.; Paviotti-Corcuera, R.

    2003-04-01

    The main discussions and conclusions from the Third Co-ordination Meeting on the Development of a Database for Prompt γ-ray Neutron Activation Analysis are summarised in this report. All results were reviewed in detail, and the final version of the TECDOC and the corresponding software were agreed upon and approved for preparation. Actions were formulated with the aim of completing the final version of the TECDOC and associated software by May 2003. (author)

  17. Combined cycle versus one thousand diesel power plants: pollutant emissions, ecological efficiency and economic analysis

    International Nuclear Information System (INIS)

    Silveira, Jose Luz; de Carvalho, Joao Andrade; de Castro Villela, Iraides Aparecida

    2007-01-01

    The increase in the use of natural gas in Brazil has stimulated public and private sectors to analyse the possibility of using combined cycle systems for generation of electrical energy. Gas turbine combined cycle power plants are becoming increasingly common due to their high efficiency, short lead times, and ability to meet environmental standards. Power is produced in a generator linked directly to the gas turbine. The gas turbine exhaust gases are sent to a heat recovery steam generator to produce superheated steam that can be used in a steam turbine to produce additional power. In this paper a comparative study between a 1000 MW combined cycle power plant and 1000kW diesel power plant is presented. In first step, the energetic situation in Brazil, the needs of the electric sector modification and the needs of demand management and integrated means planning are clarified. In another step the characteristics of large and small thermoelectric power plants that use natural gas and diesel fuel, respectively, are presented. The ecological efficiency levels of each type of power plant is considered in the discussion, presenting the emissions of particulate material, sulphur dioxide (SO 2 ), carbon dioxide (CO 2 ) and nitrogen oxides (NO x ). (author)

  18. Choice of implant combinations in total hip replacement: systematic review and network meta-analysis.

    Science.gov (United States)

    López-López, José A; Humphriss, Rachel L; Beswick, Andrew D; Thom, Howard H Z; Hunt, Linda P; Burston, Amanda; Fawsitt, Christopher G; Hollingworth, William; Higgins, Julian P T; Welton, Nicky J; Blom, Ashley W; Marques, Elsa M R

    2017-11-02

    Objective  To compare the survival of different implant combinations for primary total hip replacement (THR). Design  Systematic review and network meta-analysis. Data sources  Medline, Embase, The Cochrane Library, ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, and the EU Clinical Trials Register. Review methods  Published randomised controlled trials comparing different implant combinations. Implant combinations were defined by bearing surface materials (metal-on-polyethylene, ceramic-on-polyethylene, ceramic-on-ceramic, or metal-on-metal), head size (large ≥36 mm or small meta-analysis for revision. There was no evidence that the risk of revision surgery was reduced by other implant combinations compared with the reference implant combination. Although estimates are imprecise, metal-on-metal, small head, cemented implants (hazard ratio 4.4, 95% credible interval 1.6 to 16.6) and resurfacing (12.1, 2.1 to 120.3) increase the risk of revision at 0-2 years after primary THR compared with the reference implant combination. Similar results were observed for the 2-10 years period. 31 studies (2888 patients) were included in the analysis of Harris hip score. No implant combination had a better score than the reference implant combination. Conclusions  Newer implant combinations were not found to be better than the reference implant combination (metal-on-polyethylene (not highly cross linked), small head, cemented) in terms of risk of revision surgery or Harris hip score. Metal-on-metal, small head, cemented implants and resurfacing increased the risk of revision surgery compared with the reference implant combination. The results were consistent with observational evidence and were replicated in sensitivity analysis but were limited by poor reporting across studies. Systematic review registration  PROSPERO CRD42015019435. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence

  19. Analysis of the Interactions of Botanical Extract Combinations Against the Viability of Prostate Cancer Cell Lines

    Directory of Open Access Journals (Sweden)

    Lynn S. Adams

    2006-01-01

    Full Text Available Herbal medicines are often combinations of botanical extracts that are assumed to have additive or synergistic effects. The purpose of this investigation was to compare the effect of individual botanical extracts with combinations of extracts on prostate cell viability. We then modeled the interactions between botanical extracts in combination isobolographically. Scutellaria baicalensis, Rabdosia rubescens, Panax-pseudo ginseng, Dendranthema morifolium, Glycyrrhiza uralensis and Serenoa repens were collected, taxonomically identified and extracts prepared. Effects of the extracts on cell viability were quantitated in prostate cell lines using a luminescent ATP cell viability assay. Combinations of two botanical extracts of the four most active extracts were tested in the 22Rv1 cell line and their interactions assessed using isobolographic analysis. Each extract significantly inhibited the proliferation of prostate cell lines in a time- and dose-dependent manner except repens. The most active extracts, baicalensis, D. morifolium, G. uralensis and R. rubescens were tested as two-extract combinations. baicalensis and D. morifolium when combined were additive with a trend toward synergy, whereas D. morifolium and R. rubescens together were additive. The remaining two-extract combinations showed antagonism. The four extracts together were significantly more effective than the two-by-two combinations and the individual extracts alone. Combining the four herbal extracts significantly enhanced their activity in the cell lines tested compared with extracts alone. The less predictable nature of the two-way combinations suggests a need for careful characterization of the effects of each individual herb based on their intended use.

  20. 78 FR 72718 - NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting

    Science.gov (United States)

    2013-12-03

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (13-139)] NASA Advisory Council; Audit... amended, the National Aeronautics and Space Administration announces a meeting of the Audit, Finance and... includes briefings on the following topics: Finance Update Budget Update NASA Strategic Planning and...

  1. 76 FR 4380 - NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting.

    Science.gov (United States)

    2011-01-25

    ..., Office of the Chief Financial Officer. (OCFO), National Aeronautics and Space Administration Headquarters... meeting includes the following topics: Review of FY2010 Financial Statement Audit and Roadmap to Unqualified Opinion in FY 2011. Chief Financial Officer Update and Review of OCFO Responsibilities. Financial...

  2. An Integrated Strategy Framework (ISF) for Combining Porter's 5-Forces, Diamond, PESTEL, and SWOT Analysis

    OpenAIRE

    Anton, Roman

    2015-01-01

    INTRODUCTION Porter's Five-Forces, Porter's Diamond, PESTEL, the 6th-Forths, and Humphrey's SWOT analysis are among the most important and popular concepts taught in business schools around the world. A new integrated strategy framework (ISF) combines all major concepts. PURPOSE Porter's Five-Forces, Porter's Diamond, PESTEL, the 6th-Forths, and Humphrey's SWOT analysis are among the most important and popular concepts taught in business schools around the world. A new integrated strategy fr...

  3. Preliminary analysis of combined cycle of modular high-temperature gas cooled reactor

    International Nuclear Information System (INIS)

    Baogang, Z.; Xiaoyong, Y.; Jie, W.; Gang, Z.; Qian, S.

    2015-01-01

    Modular high-temperature gas cooled reactor (HTGR) is known as one of the most advanced nuclear reactors because of its inherent safety and high efficiency. The power conversion system of HTGR can be steam turbine based on Rankine cycle or gas turbine based on Brayton cycle respectively. The steam turbine system is mature and the gas turbine system has high efficiency but under development. The Brayton-Rankine combined cycle is an effective way to further promote the efficiency. This paper investigated the performance of combined cycle from the viewpoint of thermodynamics. The effect of non-dimensional parameters on combined cycle’s efficiency, such as temperature ratio, compression ratio, efficiency of compressor, efficiency of turbine, was analyzed. Furthermore, the optimal parameters to achieve highest efficiency was also given by this analysis under engineering constraints. The conclusions could be helpful to the design and development of combined cycle of HTGR. (author)

  4. Reliability analysis of production ships with emphasis on load combination and ultimate strength

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Xiaozhi

    1995-05-01

    This thesis deals with ultimate strength and reliability analysis of offshore production ships, accounting for stochastic load combinations, using a typical North Sea production ship for reference. A review of methods for structural reliability analysis is presented. Probabilistic methods are established for the still water and vertical wave bending moments. Linear stress analysis of a midships transverse frame is carried out, four different finite element models are assessed. Upon verification of the general finite element code ABAQUS with a typical ship transverse girder example, for which test results are available, ultimate strength analysis of the reference transverse frame is made to obtain the ultimate load factors associated with the specified pressure loads in Det norske Veritas Classification rules for ships and rules for production vessels. Reliability analysis is performed to develop appropriate design criteria for the transverse structure. It is found that the transverse frame failure mode does not seem to contribute to the system collapse. Ultimate strength analysis of the longitudinally stiffened panels is performed, accounting for the combined biaxial and lateral loading. Reliability based design of the longitudinally stiffened bottom and deck panels is accomplished regarding the collapse mode under combined biaxial and lateral loads. 107 refs., 76 refs., 37 tabs.

  5. Process Monitoring by combining several signal-analysis results using fuzzy logic

    International Nuclear Information System (INIS)

    Schoonwelle, H.; Van der Hagen, T.H.J.J.; Hoogenboom, J.E.

    1996-01-01

    In order to improve reliability in detecting anomalies in nuclear power plant performance, a method is presented which is based on acquiring various characteristics of signal data using autoregressive, wavelet and fractal-analysis techniques. These characteristics are combined using a decision making approach based on fuzzy logic. This approach is able to detect and distinguish several system states

  6. Urban Saturated Power Load Analysis Based on a Novel Combined Forecasting Model

    Directory of Open Access Journals (Sweden)

    Huiru Zhao

    2015-03-01

    Full Text Available Analysis of urban saturated power loads is helpful to coordinate urban power grid construction and economic social development. There are two different kinds of forecasting models: the logistic curve model focuses on the growth law of the data itself, while the multi-dimensional forecasting model considers several influencing factors as the input variables. To improve forecasting performance, a novel combined forecasting model for saturated power load analysis was proposed in this paper, which combined the above two models. Meanwhile, the weights of these two models in the combined forecasting model were optimized by employing a fruit fly optimization algorithm. Using Hubei Province as the example, the effectiveness of the proposed combined forecasting model was verified, demonstrating a higher forecasting accuracy. The analysis result shows that the power load of Hubei Province will reach saturation in 2039, and the annual maximum power load will reach about 78,630 MW. The results obtained from this proposed hybrid urban saturated power load analysis model can serve as a reference for sustainable development for urban power grids, regional economies, and society at large.

  7. A Hybrid Approach to Composite Damage and Failure Analysis Combining Synergistic Damage Mechanics and Peridynamics

    Science.gov (United States)

    2017-09-30

    other provision of law, no person shall be subject to any penalty for fai ling to comply with a collection of information if it does not display a...to Composite Damage and Fai lure Analysis Combining Synergistic Damage Mechanics and Peridynamics Sb. GRANT NUMBER NOOO 14-16-1-2173 Sc. PROGRAM

  8. Sample preparation for combined chemical analysis and bioassay application in water quality assessment

    NARCIS (Netherlands)

    Kolkman, A.; Schriks, M.; Brand, W; Bäuerlein, P.S.; van der Kooi, M.M.E.; van Doorn, R.H.; Emke, E.; Reus, A.; van der Linden, S.; de Voogt, P.; Heringa, M.B.

    2013-01-01

    The combination of in vitro bioassays and chemical screening can provide a powerful toolbox to determine biologically relevant compounds in water extracts. In this study, a sample preparation method is evaluated for the suitability for both chemical analysis and in vitro bioassays. A set of 39

  9. Combining soft system methodology and pareto analysis in safety management performance assessment : an aviation case

    NARCIS (Netherlands)

    Karanikas, Nektarios

    2016-01-01

    Although reengineering is strategically advantageous for organisations in order to keep functional and sustainable, safety must remain a priority and respective efforts need to be maintained. This paper suggests the combination of soft system methodology (SSM) and Pareto analysis on the scope of

  10. Determination of the input parameters for inelastic background analysis combined with HAXPES using a reference sample

    DEFF Research Database (Denmark)

    Zborowski, C.; Renault, O; Torres, A

    2018-01-01

    The recent progress in HAXPES combined with Inelastic Background Analysis makes this method a powerful, non-destructive solution to get quantitative information on deeply buried layers and interfaces at depths up to 70. nm. However, we recently highlighted the need for carefully choosing the scat...

  11. Thermodynamic analysis of a new combined cooling and power system using ammonia–water mixture

    International Nuclear Information System (INIS)

    Wang, Jiangfeng; Wang, Jianyong; Zhao, Pan; Dai, Yiping

    2016-01-01

    Highlights: • A new combined cooling and power system is proposed. • Exergy destruction analysis is used to identify irreversibility of components in system. • Thermodynamic parameter analysis is performed for system. - Abstract: In order to achieve both power and cooling supply for users, a new combined cooling and power system using ammonia–water mixture is proposed to utilizing low grade heat sources, such as industrial waste heat, solar energy and geothermal energy. The proposed system combines a Kalina cycle and an ammonia–water absorption refrigeration cycle, in which the ammonia–water turbine exhaust is delivered to a separator to extract purer ammonia vapor. The purer ammonia vapor enters an evaporator to generate refrigeration output after being condensed and throttled. Mathematical models are established to simulate the combined system under steady-state conditions. Exergy destruction analysis is conducted to display the exergy destruction distribution in the system qualitatively and the results show that the major exergy destruction occurs in the heat exchangers. Finally a thermodynamic sensitivity analysis is performed and reveals that with an increase in the pressure of separator I or the ammonia mass fraction of basic solution, thermal efficiency and exergy efficiency of the system increase, whereas with an increase in the temperature of separator I, the ammonia–water turbine back pressure or the condenser II pressure, thermal efficiency and exergy efficiency of the system drop.

  12. Statistical assessment on a combined analysis of GRYN-ROMN-UCBN upland vegetation vital signs

    Science.gov (United States)

    Irvine, Kathryn M.; Rodhouse, Thomas J.

    2014-01-01

    As of 2013, Rocky Mountain and Upper Columbia Basin Inventory and Monitoring Networks have multiple years of vegetation data and Greater Yellowstone Network has three years of vegetation data and monitoring is ongoing in all three networks. Our primary objective is to assess whether a combined analysis of these data aimed at exploring correlations with climate and weather data is feasible. We summarize the core survey design elements across protocols and point out the major statistical challenges for a combined analysis at present. The dissimilarity in response designs between ROMN and UCBN-GRYN network protocols presents a statistical challenge that has not been resolved yet. However, the UCBN and GRYN data are compatible as they implement a similar response design; therefore, a combined analysis is feasible and will be pursued in future. When data collected by different networks are combined, the survey design describing the merged dataset is (likely) a complex survey design. A complex survey design is the result of combining datasets from different sampling designs. A complex survey design is characterized by unequal probability sampling, varying stratification, and clustering (see Lohr 2010 Chapter 7 for general overview). Statistical analysis of complex survey data requires modifications to standard methods, one of which is to include survey design weights within a statistical model. We focus on this issue for a combined analysis of upland vegetation from these networks, leaving other topics for future research. We conduct a simulation study on the possible effects of equal versus unequal probability selection of points on parameter estimates of temporal trend using available packages within the R statistical computing package. We find that, as written, using lmer or lm for trend detection in a continuous response and clm and clmm for visually estimated cover classes with “raw” GRTS design weights specified for the weight argument leads to substantially

  13. 3. research coordination meeting on development of a reference data base for ion beam analysis. Summary report

    International Nuclear Information System (INIS)

    Abriola, D.; Vickridge, I.

    2009-12-01

    Highlights of the third and last Research Coordination Meeting are given with respect to the progress achieved in the Co-ordinated Research Project on Development of a Reference Database for Ion Beam Analysis. The meeting took place at the IAEA headquarters in Vienna from 27 March to 3 April 2009. Participants presented the results of their work and identified and assigned key tasks in pursuance of the final output of the CRP, in particular the update of the IBANDL library and the drafting of the final Technical Report of the CRP. In addition, a number of productive discussions took place concerning issues such as measurements, assessments, evaluations, benchmarks and recommendations. The main conclusions as well as lists of responsibilities and tasks towards the production of the final report are presented. (author)

  14. 'AER working group D on VVER safety analysis' minutes of the meeting in Rossendorf, Germany, 10-12 May 1999

    International Nuclear Information System (INIS)

    Siltanen, P.

    1999-01-01

    AER Working Group D on VVER reactor safety analysis held its eighth meeting in Research Centre Rossendorf during the period 10-12 May 1999. There were altogether 14 participants from eight member organizations. In addition to the general information exchange on recent activities, the topics of the meeting included: Final conclusions and lessons from the solution of the AER Dynamic Benchmark Problem No. 5 on a main steam header break accident; Validation of dynamics codes and the definition of a 6th dynamic benchmark; Safety analyses and reactivity issues: approaches and results; Advances in development of models and codes for reactor dynamics applications; Documentation of dynamic benchmark problems and solutions for the AER Benchmark Book; Future activities. (author)

  15. Multi-dimensional project evaluation: Combining cost-benefit analysis and multi-criteria analysis with the COSIMA software system

    DEFF Research Database (Denmark)

    and not the least construction and maintenance costs. The MCA is made use of to assess noise, land use planning, business potential and tourism impacts for the three alternatives. More technically the software system offers a set of different features to undertake the MCA. Thus the users have two different methods...... for society is ranked uppermost. To compare the different impacts, it is necessary to have a common monetary unit. Theoretically, all benefits and all costs should be accounted for in socio-economic cost-benefit analysis. However, this is far from in practical the general case due to difficulties...... in a valuating all the criteria in monetary terms. Thus CBA does not meet the need for a comprehensive evaluation, for which reason MCA is introduced to overcome this problem. Not only does MCA provides an opportunity to include non-market impacts in the analysis, but MCA also provides a framework for breaking...

  16. Impact of LABA/LAMA combination on exercise endurance and lung hyperinflation in COPD: A pair-wise and network meta-analysis.

    Science.gov (United States)

    Calzetta, Luigino; Ora, Josuel; Cavalli, Francesco; Rogliani, Paola; O'Donnell, Denis E; Cazzola, Mario

    2017-08-01

    The ability to exercise is an important clinical outcome in COPD, and the improvement in exercise capacity is recognized to be an important goal in the management of COPD. Therefore, since the current interest in the use of bronchodilators in COPD is gradually shifting towards the dual bronchodilation, we carried out a meta-analysis to evaluate the impact of LABA/LAMA combination on exercise capacity and lung hyperinflation in COPD. RCTs were identified after a search in different databases of published and unpublished trials. The aim of this study was to assess the influence of LABA/LAMA combinations on endurance time (ET) and inspiratory capacity (IC), vs. monocomponents. Eight RCTs including 1632 COPD patients were meta-analysed. LABA/LAMA combinations were significantly (P meta-analysis. This meta-analysis clearly demonstrates that if the goal of the therapy is to enhance exercise capacity in patients with COPD, LABA/LAMA combinations consistently meet the putative clinically meaningful differences for both ET and IC and, in this respect, are superior to their monocomponents. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Meta-analysis of individual and combined effects of mycotoxins on growing pigs

    Directory of Open Access Journals (Sweden)

    Ines Andretta

    2016-08-01

    Full Text Available ABSTRACT Little is known about the toxicity of concomitantly occurring mycotoxins in pig diets. This study was conducted to evaluate, through meta-analysis, the individual and the combined effects of mycotoxins on pig performance. The meta-analysis followed three sequential analyses (graphical, correlation, and variance-covariance based on a database composed of 85 published papers, 1,012 treatments and 13,196 animals. Contamination of diets with individual mycotoxins reduced (p < 0.05 feed intake by 14 % and weight gain by 17 %, while combined mycotoxins reduced the same responses by 42 % and 45 %, respectively, in comparison with the non-challenged group. The correlation (p < 0.05 between reduction in weight gain (ΔG and reduction in feed intake (ΔFI was 0.67 in individual challenges and 0.93 in combined challenges. The estimated ΔG was –6 % in individual challenges and –7 % in combined challenges when ΔFI was zero, suggesting an increase in the maintenance requirements of challenged animals. Most of ΔG (58 % in individual challenges and 84 % in combined challenges was attributed to the changes in feed efficiency. The association of mycotoxins enhances individual toxic effects and the ΔFI is important in explaining the deleterious effects on the growth of challenged pigs.

  18. The analysis of uranium in environmental sample by mass spectrometer combined with isotopic dilution

    International Nuclear Information System (INIS)

    Fu Zhonghua; Jia Baoting; Han Jun

    2003-01-01

    Uranium in the environmental sample was analyzed by mass spectrometer combined with isotopic dilution. Before mass spectrometer analysis, samples were dissolved in a concentrated acidic solution containing HNO 3 , HF and HClO 4 and chemically processed to suit the analysis requirement. Analysis results indicated that the uranium content was 0.08 μg/g in river water, 0.1 μg/g in evergreen foliage, and 5-11 μg/g in surface soil respectively. (authors)

  19. Analysis of Marine Corps renewable energy planning to meet installation energy security requirements

    OpenAIRE

    Chisom, Christopher M.; Templenton, Jack C., II

    2013-01-01

    Approved for public release; distribution is unlimited. The purpose of this thesis is to analyze Marine Corps installation energy consumption and the pursuit of increased renewable energy generation goals across Marine Corps installations. The main objective of this report is to determine the cost of interruption and the net present value (NPV) of renewable energy generation needed to meet the Marine Corps energy security objectives. First, we determine installation-specific energy consump...

  20. Cost-effectiveness analysis of combination therapies for visceral leishmaniasis in the Indian subcontinent.

    Directory of Open Access Journals (Sweden)

    Filip Meheus

    2010-09-01

    Full Text Available Visceral leishmaniasis is a systemic parasitic disease that is fatal unless treated. We assessed the cost and cost-effectiveness of alternative strategies for the treatment of visceral leishmaniasis in the Indian subcontinent. In particular we examined whether combination therapies are a cost-effective alternative compared to monotherapies.We assessed the cost-effectiveness of all possible mono- and combination therapies for the treatment of visceral leishmaniasis in the Indian subcontinent (India, Nepal and Bangladesh from a societal perspective using a decision analytical model based on a decision tree. Primary data collected in each country was combined with data from the literature and an expert poll (Delphi method. The cost per patient treated and average and incremental cost-effectiveness ratios expressed as cost per death averted were calculated. Extensive sensitivity analysis was done to evaluate the robustness of our estimations and conclusions. With a cost of US$92 per death averted, the combination miltefosine-paromomycin was the most cost-effective treatment strategy. The next best alternative was a combination of liposomal amphotericin B with paromomycin with an incremental cost-effectiveness of $652 per death averted. All other strategies were dominated with the exception of a single dose of 10mg per kg of liposomal amphotericin B. While strategies based on liposomal amphotericin B (AmBisome were found to be the most effective, its current drug cost of US$20 per vial resulted in a higher average cost-effectiveness. Sensitivity analysis showed the conclusion to be robust to variations in the input parameters over their plausible range.Combination treatments are a cost-effective alternative to current monotherapy for VL. Given their expected impact on the emergence of drug resistance, a switch to combination therapy should be considered once final results from clinical trials are available.

  1. A combined Bodian-Nissl stain for improved network analysis in neuronal cell culture.

    Science.gov (United States)

    Hightower, M; Gross, G W

    1985-11-01

    Bodian and Nissl procedures were combined to stain dissociated mouse spinal cord cells cultured on coverslips. The Bodian technique stains fine neuronal processes in great detail as well as an intracellular fibrillar network concentrated around the nucleus and in proximal neurites. The Nissl stain clearly delimits neuronal cytoplasm in somata and in large dendrites. A combination of these techniques allows the simultaneous depiction of neuronal perikarya and all afferent and efferent processes. Costaining with little background staining by either procedure suggests high specificity for neurons. This procedure could be exploited for routine network analysis of cultured neurons.

  2. Analysis of simultaneous measurement of temperature and strain using different combinations of FBG

    Science.gov (United States)

    Ashik T., J.; Kachare, Nitin; Kalyani bai, K.; Kumar, D. Sriram

    2017-06-01

    The Fiber Bragg Grating (FBG) can be used for measuring temperature and or strain. In this paper analysis of different combinations of FBG is made. Certain parameters of FBG are considered such as Bandwidth, Side lobes, Peak power, and Sensitivity. Simultaneous measurement of temperature and strain is made using two combinations of FBG. The setup is simulated using two software. Optigrating 4.2.2 is used for designing different types of gratings such as Uniform, Apodized, Tilted and Superstructure. After designing, these files are exported to Optisystem 12 to simulate the spectrum and to observe the parameters.

  3. Ongoing Analysis of Rocket Based Combined Cycle Engines by the Applied Fluid Dynamics Analysis Group at Marshall Space Flight Center

    Science.gov (United States)

    Ruf, Joseph; Holt, James B.; Canabal, Francisco

    1999-01-01

    This paper presents the status of analyses on three Rocket Based Combined Cycle configurations underway in the Applied Fluid Dynamics Analysis Group (TD64). TD64 is performing computational fluid dynamics analysis on a Penn State RBCC test rig, the proposed Draco axisymmetric RBCC engine and the Trailblazer engine. The intent of the analysis on the Penn State test rig is to benchmark the Finite Difference Navier Stokes code for ejector mode fluid dynamics. The Draco engine analysis is a trade study to determine the ejector mode performance as a function of three engine design variables. The Trailblazer analysis is to evaluate the nozzle performance in scramjet mode. Results to date of each analysis are presented.

  4. Thermodynamic Analysis of a Ship Power Plant Operating with Waste Heat Recovery through Combined Heat and Power Production

    Directory of Open Access Journals (Sweden)

    Mirko Grljušić

    2014-11-01

    Full Text Available The goal of this research is to study a cogeneration plant for combined heat & power (CHP production that utilises the low-temperature waste energy in the power plant of a Suezmax-size oil tanker for all heating and electricity requirements during navigation. After considering various configurations, a standard propulsion engine operating at maximum efficiency and a CHP Plant with R245fa fluid using a supercritical organic Rankine cycle (ORC is selected. All the ship heat requirements can be covered by energy of organic fluid after expansion in the turbine, except feeder-booster heating. Hence, an additional quantity of working fluid may be heated using an after Heat Recovery Steam Generator (HRSG directed to the feeder-booster module. An analysis of the obtained results shows that the steam turbine plant does not yield significant fuel savings. However, a CHP plant with R245fa fluid using supercritical ORC meets all of the demands for electrical energy and heat while burning only a small amount of additional fuel in HRSG at the main engine off-design operation.

  5. Unpacking Big Systems -- Natural Language Processing Meets Network Analysis. A Study of Smart Grid Development in Denmark

    DEFF Research Database (Denmark)

    Jurowetzki, Roman

    and contained technological trajectories on a national level using a combination of methods from statistical natural language processing, vector space modelling and network analysis. The proposed approach does not aim at replacing the researcher or expert but rather offers the possibility to algorithmically...... in Denmark. Results show that in the explored case it is not mainly new technologies and applications that are driving change but innovative re-combinations of old and new technologies....

  6. The colorimetric analysis of anti-tuberculosis fixed-dose combination tablets and capsules.

    Science.gov (United States)

    Ellard, G A

    1999-11-01

    The perceived need to demonstrate whether or not the actual amounts of rifampicin, isoniazid and pyrazinamide in fixed-dose combination tablets or capsules correspond to their stated drug contents. To adapt specific, robust and simple colorimetric methods that have been previously applied to measuring plasma and urinary rifampicin, isoniazid, pyrazinamide and ethambutol concentrations to estimate tablet and capsule drug contents. The methods were applied to the analysis of 14 commercially manufactured fixed-dose combinations: two capsule and three tablet formulations containing rifampicin and isoniazid; seven tablet formulations containing rifampicin, isoniazid and pyrazinamide; and two tablet formulations containing rifampicin, isoniazid, pyrazinamide and ethambutol. All the combined formulations contained near to their stated drug contents. Replicate analyses confirmed the excellent precision of the drug analyses. Such methods are not only rapid to perform but should be practical in many Third World situations with relatively modest laboratory facilities.

  7. Image Denoising Algorithm Combined with SGK Dictionary Learning and Principal Component Analysis Noise Estimation

    Directory of Open Access Journals (Sweden)

    Wenjing Zhao

    2018-01-01

    Full Text Available SGK (sequential generalization of K-means dictionary learning denoising algorithm has the characteristics of fast denoising speed and excellent denoising performance. However, the noise standard deviation must be known in advance when using SGK algorithm to process the image. This paper presents a denoising algorithm combined with SGK dictionary learning and the principal component analysis (PCA noise estimation. At first, the noise standard deviation of the image is estimated by using the PCA noise estimation algorithm. And then it is used for SGK dictionary learning algorithm. Experimental results show the following: (1 The SGK algorithm has the best denoising performance compared with the other three dictionary learning algorithms. (2 The SGK algorithm combined with PCA is superior to the SGK algorithm combined with other noise estimation algorithms. (3 Compared with the original SGK algorithm, the proposed algorithm has higher PSNR and better denoising performance.

  8. Combined Measurement and QCD Analysis of the Inclusive ep Scattering Cross Sections at HERA

    CERN Document Server

    Aaron, F.D.; Abt, I.; Adamczyk, L.; Adamus, M.; Aldaya Martin, M.; Alexa, C.; Andreev, V.; Antonelli, S.; Antonioli, P.; Antonov, A.; Antunovic, B.; Arneodo, M.; Aushev, V.; Bachynska, O.; Backovic, S.; Baghdasaryan, A.; Bamberger, A.; Barakbaev, A.N.; Barbagli, G.; Bari, G.; Barreiro, F.; Barrelet, E.; Bartel, W.; Bartsch, D.; Basile, M.; Begzsuren, K.; Behnke, O.; Behr, J.; Behrens, U.; Bellagamba, L.; Belousov, A.; Bertolin, A.; Bhadra, S.; Bindi, M.; Bizot, J.C.; Blohm, C.; Bold, T.; Boos, E.G.; Borodin, M.; Borras, K.; Boscherini, D.; Bot, D.; Boudry, V.; Boutle, S.K.; Bozovic-Jelisavcic, I.; Bracinik, J.; Brandt, G.; Brinkmann, M.; Brisson, V.; Brock, I.; Brownson, E.; Brugnera, R.; Brummer, N.; Bruncko, D.; Bruni, A.; Bruni, G.; Brzozowska, B.; Bunyatyan, A.; Buschhorn, G.; Bussey, P.J.; Butterworth, J.M.; Bylsma, B.; Bystritskaya, L.; Caldwell, A.; Campbell, A.J.; Cantun Avila, K.B.; Capua, M.; Carlin, R.; Catterall, C.D.; Cerny, K.; Cerny, V.; Chekanov, S.; Chekelian, V.; Cholewa, A.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cifarelli, L.; Cindolo, F.; Contin, A.; Contreras, J.G.; Cooper-Sarkar, A.M.; Coppola, N.; Corradi, M.; Corriveau, F.; Costa, M.; Coughlan, J.A.; Cozzika, G.; Cvach, J.; D'Agostini, G.; Dainton, J.B.; Dal Corso, F.; Daum, K.; Deak, M.; de Favereau, J.; Delcourt, B.; del Peso, J.; Delvax, J.; Dementiev, R.K.; De Pasquale, S.; Derrick, M.; Devenish, R.C.E.; De Wolf, E.A.; Diaconu, C.; Dobur, D.; Dodonov, V.; Dolgoshein, B.A.; Dossanov, A.; Doyle, A.T.; Drugakov, V.; Dubak, A.; Durkin, L.S.; Dusini, S.; Eckerlin, G.; Efremenko, V.; Egli, S.; Eisenberg, Y.; Eliseev, A.; Elsen, E.; Ermolov, P.F.; Eskreys, A.; Falkiewicz, A.; Fang, S.; Favart, L.; Fazio, S.; Fedotov, A.; Felst, R.; Feltesse, J.; Ferencei, J.; Ferrando, J.; Ferrero, M.I.; Figiel, J.; Fischer, D.J.; Fleischer, M.; Fomenko, A.; Forrest, M.; Foster, B.; Fourletov, S.; Gabathuler, E.; Galas, A.; Gallo, E.; Garfagnini, A.; Gayler, J.; Geiser, A.; Ghazaryan, S.; Gialas, I.; Gladilin, L.K.; Gladkov, D.; Glasman, C.; Glazov, A.; Glushkov, I.; Goerlich, L.; Gogitidze, N.; Golubkov, Yu.A.; Gottlicher, P.; Gouzevitch, M.; Grab, C.; Grabowska-Bold, I.; Grebenyuk, J.; Greenshaw, T.; Gregor, I.; Grell, B.R.; Grigorescu, G.; Grindhammer, G.; Grzelak, G.; Gwenlan, C.; Haas, T.; Habib, S.; Haidt, D.; Hain, W.; Hamatsu, R.; Hart, J.C.; Hartmann, H.; Hartner, G.; Helebrant, C.; Henderson, R.C.W.; Hennekemper, E.; Henschel, H.; Herbst, M.; Herrera, G.; Hildebrandt, M.; Hilger, E.; Hiller, K.H.; Hochman, D.; Hoffmann, D.; Holm, U.; Hori, R.; Horisberger, R.; Horton, K.; Hreus, T.; Huttmann, A.; Iacobucci, G.; Ibrahim, Z.A.; Iga, Y.; Ingbir, R.; Ishitsuka, M.; Jacquet, M.; Jakob, H.P.; Janssen, X.; Januschek, F.; Jimenez, M.; Jones, T.W.; Jonsson, L.; Jung, A.W.; Jung, H.; Jungst, M.; Kadenko, I.; Kahle, B.; Kamaluddin, B.; Kananov, S.; Kanno, T.; Kapichine, M.; Karshon, U.; Karstens, F.; Katkov, I.I.; Katzy, J.; Kaur, M.; Kaur, P.; Kenyon, I.R.; Keramidas, A.; Khein, L.A.; Kiesling, C.; Kim, J.Y.; Kisielewska, D.; Kitamura, S.; Klanner, R.; Klein, M.; Klein, U.; Kleinwort, C.; Kluge, T.; Knutsson, A.; Koffeman, E.; Kogler, R.; Kollar, D.; Kooijman, P.; Korol, Ie.; Korzhavina, I.A.; Kostka, P.; Kotanski, A.; Kotz, U.; Kowalski, H.; Kraemer, M.; Krastev, K.; Kretzschmar, J.; Kropivnitskaya, A.; Kruger, K.; Kulinski, P.; Kuprash, O.; Kutak, K.; Kuze, M.; Kuzmin, V.A.; Landon, M.P.J.; Lange, W.; Lastovicka-Medin, G.; Laycock, P.; Lebedev, A.; Lee, A.; Lendermann, V.; Levchenko, B.B.; Levonian, S.; Levy, A.; Li, G.; Libov, V.; Limentani, S.; Ling, T.Y.; Lipka, K.; Liptaj, A.; Lisovyi, M.; List, B.; List, J.; Lobodzinska, E.; Lohmann, W.; Lohr, B.; Lohrmann, E.; Loizides, J.H.; Loktionova, N.; Long, K.R.; Longhin, A.; Lontkovskyi, D.; Lopez-Fernandez, R.; Lubimov, V.; Lukasik, J.; Lukina, O.Yu.; Luzniak, P.; Maeda, J.; Magill, S.; Makankine, A.; Makarenko, I.; Malinovski, E.; Malka, J.; Mankel, R.; Marage, P.; Margotti, A.; Marini, G.; Marti, Ll.; Martin, J.F.; Martyn, H.U.; Mastroberardino, A.; Matsumoto, T.; Mattingly, M.C.K.; Maxfield, S.J.; Mehta, A.; Melzer-Pellmann, I.A.; Meyer, A.B.; Meyer, H.; Meyer, H.; Meyer, J.; Miglioranzi, S.; Mikocki, S.; Milcewicz-Mika, I.; Mohamad Idris, F.; Monaco, V.; Montanari, A.; Moreau, F.; Morozov, A.; Morris, J.D.; Morris, J.V.; Mozer, M.U.; Mudrinic, M.; Muller, K.; Murin, P.; Musgrave, B.; Nagano, K.; Namsoo, T.; Nania, R.; Naumann, Th.; Newman, P.R.; Nicholass, D.; Niebuhr, C.; Nigro, A.; Nikiforov, A.; Nikitin, D.; Ning, Y.; Noor, U.; Notz, D.; Nowak, G.; Nowak, K.; Nowak, R.J.; Nuncio-Quiroz, A.E.; Oh, B.Y.; Okazaki, N.; Oliver, K.; Olkiewicz, K.; Olsson, J.E.; Onishchuk, Yu.; Osman, S.; Ota, O.; Ozerov, D.; Palichik, V.; Panagoulias, I.; Pandurovic, M.; Papadopoulou, Th.; Papageorgiu, K.; Parenti, A.; Pascaud, C.; Patel, G.D.; Paul, E.; Pawlak, J.M.; Pawlik, B.; Pejchal, O.; Pelfer, P.G.; Pellegrino, A.; Perez, E.; Perlanski, W.; Perrey, H.; Petrukhin, A.; Picuric, I.; Piec, S.; Piotrzkowski, K.; Pitzl, D.; Placakyte, R.; Plucinski, P.; Pokorny, B.; Pokrovskiy, N.S.; Polifka, R.; Polini, A.; Povh, B.; Proskuryakov, A.S.; Przybycien, M.; Radescu, V.; Rahmat, A.J.; Raicevic, N.; Raspiareza, A.; Raval, A.; Ravdandorj, T.; Reeder, D.D.; Reimer, P.; Reisert, B.; Ren, Z.; Repond, J.; Ri, Y.D.; Rizvi, E.; Robertson, A.; Robmann, P.; Roland, B.; Roloff, P.; Ron, E.; Roosen, R.; Rostovtsev, A.; Rotaru, M.; Rubinsky, I.; Ruiz Tabasco, J.E.; Rusakov, S.; Ruspa, M.; Sacchi, R.; Salek, D.; Salii, A.; Samson, U.; Sankey, D.P.C.; Sartorelli, G.; Sauter, M.; Sauvan, E.; Savin, A.A.; Saxon, D.H.; Schioppa, M.; Schlenstedt, S.; Schleper, P.; Schmidke, W.B.; Schmitt, S.; Schneekloth, U.; Schoeffel, L.; Schonberg, V.; Schoning, A.; Schorner-Sadenius, T.; Schultz-Coulon, H.C.; Schwartz, J.; Sciulli, F.; Sefkow, F.; Shaw-West, R.N.; Shcheglova, L.M.; Shehzadi, R.; Shimizu, S.; Shtarkov, L.N.; Shushkevich, S.; Singh, I.; Skillicorn, I.O.; Sloan, T.; Slominski, W.; Smiljanic, I.; Smith, W.H.; Sola, V.; Solano, A.; Soloviev, Y.; Son, D.; Sopicki, P.; Sorokin, Iu.; Sosnovtsev, V.; South, D.; Spaskov, V.; Specka, A.; Spiridonov, A.; Stadie, H.; Stanco, L.; Staykova, Z.; Steder, M.; Stella, B.; Stern, A.; Stewart, T.P.; Stifutkin, A.; Stoicea, G.; Stopa, P.; Straumann, U.; Suchkov, S.; Sunar, D.; Susinno, G.; Suszycki, L.; Sykora, T.; Sztuk, J.; Szuba, D.; Szuba, J.; Tapper, A.D.; Tassi, E.; Tchoulakov, V.; Terron, J.; Theedt, T.; Thompson, G.; Thompson, P.D.; Tiecke, H.; Tokushuku, K.; Toll, T.; Tomasz, F.; Tomaszewska, J.; Tran, T.H.; Traynor, D.; Trinh, T.N.; Truol, P.; Tsakov, I.; Tseepeldorj, B.; Tsurugai, T.; Turcato, M.; Turnau, J.; Tymieniecka, T.; Urban, K.; Uribe-Estrada, C.; Valkarova, A.; Vallee, C.; Van Mechelen, P.; Vargas Trevino, A.; Vazdik, Y.; Vazquez, M.; Verbytskyi, A.; Viazlo, V.; Vinokurova, S.; Vlasov, N.N.; Volchinski, V.; Volynets, O.; von den Driesch, M.; Walczak, R.; Wan Abdullah, W.A.T.; Wegener, D.; Whitmore, J.J.; Whyte, J.; Wiggers, L.; Wing, M.; Wissing, Ch.; Wlasenko, M.; Wolf, G.; Wolfe, H.; Wrona, K.; Wunsch, E.; Yagues-Molina, A.G.; Yamada, S.; Yamazaki, Y.; Yoshida, R.; Youngman, C.; Zacek, J.; Zalesak, J.; Zarnecki, A.F.; Zawiejski, L.; Zeniaev, O.; Zeuner, W.; Zhang, Z.; Zhautykov, B.O.; Zhokin, A.; Zhou, C.; Zichichi, A.; Zimmermann, T.; Zohrabyan, H.; Zolko, M.; Zomer, F.; Zotkin, D.S.

    2010-01-01

    A combination is presented of the inclusive deep inelastic cross sections measured by the H1 and ZEUS Collaborations in neutral and charged current unpolarised ep scattering at HERA during the period 1994-2000. The data span six orders of magnitude in negative four-momentum-transfer squared, Q^2, and in Bjorken x. The combination method used takes the correlations of systematic uncertainties into account, resulting in an improved accuracy. The combined data are the sole input in a NLO QCD analysis which determines a new set of parton distributions HERAPDF1.0 with small experimental uncertainties. This set includes an estimate of the model and parametrisation uncertainties of the fit result.

  9. Integrated analysis of the molecular action of Vorinostat identifies epi-sensitised targets for combination therapy.

    Science.gov (United States)

    Hay, Jodie F; Lappin, Katrina; Liberante, Fabio; Kettyle, Laura M; Matchett, Kyle B; Thompson, Alexander; Mills, Ken I

    2017-09-15

    Several histone deacetylase inhibitors including Vorinostat have received FDA approval for the treatment of haematological malignancies. However, data from these trials indicate that Vorinostat has limited efficacy as a monotherapy, prompting the need for rational design of combination therapies. A number of epi-sensitised pathways, including sonic hedgehog (SHH), were identified in AML cells by integration of global patterns of histone H3 lysine 9 (H3K9) acetylation with transcriptomic analysis following Vorinostat-treatment. Direct targeting of the SHH pathway with SANT-1, following Vorinostat induced epi-sensitisation, resulted in synergistic cell death of AML cells. In addition, xenograft studies demonstrated that combination therapy induced a marked reduction in leukemic burden compared to control or single agents. Together, the data supports epi-sensitisation as a potential component of the strategy for the rational development of combination therapies in AML.

  10. Combining trace elements micro-analysis in deposited dredged sediments: EPMA and μ-XRF analysis

    International Nuclear Information System (INIS)

    Poitevin, A; Lerouge, C; Wille, G; Bataillard, P; Quinn, P; Hennet, L

    2012-01-01

    Since deposited dredged sediments are rich in metallic contaminants, they present a risk for environment. This work aims to study dredged sediments chemical composition, identify metal-carrier minerals and understand their mobility. Combining chemical and spectroscopic techniques at multi-scale for an integrative approach of trace elements (zinc, lead, iron) behaviour is therefore necessary. The global mineralogy and the chemistry of the sediment were determined by X-ray diffraction and fluorescence (XRF), respectively. Zn and Pb enriched fractions were separated using a sequential chemical extraction procedure and measured by inductively coupled plasma atomic emission and mass spectroscopy. Microanalyses using scanning electron microscopy (SEM), electron microprobe microanalysis (EPMA), combined with synchrotron radiation X-ray fluorescence (μ-XRF) were carried out to characterize mineralogical phases and identify Zn and Pb carrier minerals. Iron oxyhydroxides and iron sulphides were consistently identify as Zn and Pb carriers. The assumption that carbonate fraction was the major Zn carried phase, as demonstrated by chemical extraction results, was not verified by EPMA or μ-XRF.

  11. Meeting human resources for health staffing goals by 2018: a quantitative analysis of policy options in Zambia

    Directory of Open Access Journals (Sweden)

    Schroder Kate

    2010-06-01

    Full Text Available Abstract Background The Ministry of Health (MOH in Zambia is currently operating with fewer than half of the health workers required to deliver basic health services. The MOH has developed a human resources for health (HRH strategic plan to address the crisis through improved training, hiring, and retention. However, the projected success of each strategy or combination of strategies is unclear. Methods We developed a model to forecast the size of the public sector health workforce in Zambia over the next ten years to identify a combination of interventions that would expand the workforce to meet staffing targets. The key forecasting variables are training enrolment, graduation rates, public sector entry rates for graduates, and attrition of workforce staff. We model, using Excel (Office, Microsoft; 2007, the effects of changes in these variables on the projected number of doctors, clinical officers, nurses and midwives in the public sector workforce in 2018. Results With no changes to current training, hiring, and attrition conditions, the total number of doctors, clinical officers, nurses, and midwives will increase from 44% to 59% of the minimum necessary staff by 2018. No combination of changes in staff retention, graduation rates, and public sector entry rates of graduates by 2010, without including training expansion, is sufficient to meet staffing targets by 2018 for any cadre except midwives. Training enrolment needs to increase by a factor of between three and thirteen for doctors, three and four for clinical officers, two and three for nurses, and one and two for midwives by 2010 to reach staffing targets by 2018. Necessary enrolment increases can be held to a minimum if the rates of retention, graduation, and public sector entry increase to 100% by 2010, but will need to increase if these rates remain at 2008 levels. Conclusions Meeting the minimum need for health workers in Zambia this decade will require an increase in health

  12. The use of social media in endourology: an analysis of the 2013 World Congress of Endourology meeting.

    Science.gov (United States)

    Canvasser, Noah E; Ramo, Christina; Morgan, Todd M; Zheng, Kai; Hollenbeck, Brent K; Ghani, Khurshid R

    2015-05-01

    To examine the use of social media within Endourology by reporting on its utilization during the 2013 World Congress of Endourology (WCE) annual meeting. Two social media platforms were analyzed for this study: Twitter (San Francisco, CA) and LinkedIn (Mountain View, CA). For Twitter, a third-party analysis service (Tweetreach) was used to quantitatively analyze all tweets with the hashtags #WCE2013 and #WCE13 during a 7-day period surrounding the WCE. Two reviewers independently classified tweet content using a predefined Twitter-specific classification system. Tweet sentiment was determined using sentiment analysis software (Semantria, Inc., Amherst, MA). Finally, the penetration of Twitter and LinkedIn within the WCE faculty was assessed by means of a manual search. During the study period, 335 tweets had the hashtag #WCE2013 or #WCE13. Content originated from 68 users resulting in a mean of 47 tweets/day and 4.9 tweets/contributor. Conference-related tweets had a reach of 38,141 unique Twitter accounts and an online exposure of 188,629 impressions. Physicians generated the majority of the content (63%), of which 55.8% were not attending the meeting. More tweets were informative (56.7%) versus uninformative (43.3%), and 17.9% had links to an external web citation. The mean sentiment score was 0.13 (range -0.90 to 1.80); 13.1%, 57.0%, and 29.9% of tweets were negative, neutral, and positive in sentiment, respectively. Of 302 WCE meeting faculty, 150 (49.7%) had registered LinkedIn accounts while only 52 (17.2%) had Twitter accounts, and only 19.2% tweeted during the meeting. Despite a relatively low number of Twitter users, tweeting about the WCE meeting dramatically increased its online exposure with dissemination of content that was mostly informative including engagement with physicians not attending the conference. While half of faculty at WCE 2013 had LinkedIn accounts, their social media footprint in Twitter was limited.

  13. A critical analysis of publication rates of national oncology meeting abstracts in Turkey

    Directory of Open Access Journals (Sweden)

    S. Kilickap

    2018-04-01

    Full Text Available Purpose: In this study our aim is to analyze the publication rates of abstracts, which were presented between 2006 and 2011 years in biennial National Cancer Meeting of Turkey (NCM and Turkish Medical Oncology Society Meeting (TMOSM and to determine the timely change of publication rates and to predict the quality of the abstracts. Methods: All abstracts, which are either accepted as podium or poster presentations in NCM and TMOM between 2006 and 2011, are extracted. Subsequent publication rate of those abstracts were defined by searching PubMed and Turkish Medical Index. Results: Between 2006 and 2011, overall 2451 abstracts were presented in annual NC and TMOS meetings. Of these 2451 abstracts, 286 of them (11.7% were published in consecutive years. Median publication interval was 11 months. While 28 of 286 (9.8% abstracts were published in national journals, 258 of them (90.2% were published in international journals. 97 of a total of 424 podium presentations (22.9% were published. The publication rate was correlated with the type of presentation (OP vs. PP: 22.9% vs. 9.3%, p < 0.001. The highest publication rate was for prospective studies (%14.4. Majority of abstracts (53.1% were published in journals indexed within the science citation index (SCI. Rest of the published abstracts were in index of SCI-expanded. Conclusions: Non-publication of research abstracts is a problem for 88.3% of abstracts of this study. The data presented in this study should lead abstract authors to criticize themselves and find a way to improve their study quality. Keywords: Abstract, Full-text, Manuscript, Peer-review, Publication rate

  14. Combined Scintigraphy and Tumor Marker Analysis Predicts Unfavorable Histopathology of Neuroblastic Tumors with High Accuracy.

    Directory of Open Access Journals (Sweden)

    Wolfgang Peter Fendler

    Full Text Available Our aim was to improve the prediction of unfavorable histopathology (UH in neuroblastic tumors through combined imaging and biochemical parameters.123I-MIBG SPECT and MRI was performed before surgical resection or biopsy in 47 consecutive pediatric patients with neuroblastic tumor. Semi-quantitative tumor-to-liver count-rate ratio (TLCRR, MRI tumor size and margins, urine catecholamine and NSE blood levels of neuron specific enolase (NSE were recorded. Accuracy of single and combined variables for prediction of UH was tested by ROC analysis with Bonferroni correction.34 of 47 patients had UH based on the International Neuroblastoma Pathology Classification (INPC. TLCRR and serum NSE both predicted UH with moderate accuracy. Optimal cut-off for TLCRR was 2.0, resulting in 68% sensitivity and 100% specificity (AUC-ROC 0.86, p < 0.001. Optimal cut-off for NSE was 25.8 ng/ml, resulting in 74% sensitivity and 85% specificity (AUC-ROC 0.81, p = 0.001. Combination of TLCRR/NSE criteria reduced false negative findings from 11/9 to only five, with improved sensitivity and specificity of 85% (AUC-ROC 0.85, p < 0.001.Strong 123I-MIBG uptake and high serum level of NSE were each predictive of UH. Combined analysis of both parameters improved the prediction of UH in patients with neuroblastic tumor. MRI parameters and urine catecholamine levels did not predict UH.

  15. The Analysis Of Metaphor Used In Mitch Albom’s In Novel The Five People You Meet In Heaven

    OpenAIRE

    Sari, Eva Purnama

    2015-01-01

    This paper describes about the analysis of metaphor used in Mitch Albom in the five people you meet in heaven’s novel. The problem that is found in the discussion of this topic is what kind of metaphor used in the novel. Metaphor is coming from Greece language methaperein, (meta : moving/berpindah or relating with changing, pherein : containing/mengandung atau loading/ memuat). Metaphor is a figure of speech comparing the position of two things being the same or coparable because both of the...

  16. 5th HUPO BPP Bioinformatics Meeting at the European Bioinformatics Institute in Hinxton, UK--Setting the analysis frame.

    Science.gov (United States)

    Stephan, Christian; Hamacher, Michael; Blüggel, Martin; Körting, Gerhard; Chamrad, Daniel; Scheer, Christian; Marcus, Katrin; Reidegeld, Kai A; Lohaus, Christiane; Schäfer, Heike; Martens, Lennart; Jones, Philip; Müller, Michael; Auyeung, Kevin; Taylor, Chris; Binz, Pierre-Alain; Thiele, Herbert; Parkinson, David; Meyer, Helmut E; Apweiler, Rolf

    2005-09-01

    The Bioinformatics Committee of the HUPO Brain Proteome Project (HUPO BPP) meets regularly to execute the post-lab analyses of the data produced in the HUPO BPP pilot studies. On July 7, 2005 the members came together for the 5th time at the European Bioinformatics Institute (EBI) in Hinxton, UK, hosted by Rolf Apweiler. As a main result, the parameter set of the semi-automated data re-analysis of MS/MS spectra has been elaborated and the subsequent work steps have been defined.

  17. Intercomparison of analysis methods for seismically isolated nuclear structures. Papers and working materials presented at the 3. research coordination meeting

    International Nuclear Information System (INIS)

    1998-01-01

    The Coordinated research program on Intercomparison of analysis methods for seismically isolated nuclear structures involved participants from Italy, Japan, Republic of Korea, Russia, United Kingdom, USA, EC. The purpose of the meeting was to review the progress on the finite element prediction of the force-deformation behaviour of seismic isolators and to discuss the first set of analytical results for the prediction of the response of base-oscillated structures to earthquake inputs. The intercomparison of predictions of bearing behaviour has identified important unexpected issues requiring deeper investigation

  18. Exergy analysis of parabolic trough solar collectors integrated with combined steam and organic Rankine cycles

    International Nuclear Information System (INIS)

    Al-Sulaiman, Fahad A.

    2014-01-01

    Highlights: • As the solar irradiation increases, the exergetic efficiency increases. • The R134a combined cycle has best exergetic performance, 26%. • The R600a combined cycle has the lowest exergetic efficiency, 20%. • The main source of exergy destruction is the solar collector. • There is an exergetic improvement potential of 75% in the systems considered. - Abstract: In this paper, detailed exergy analysis of selected thermal power systems driven by parabolic trough solar collectors (PTSCs) is presented. The power is produced using either a steam Rankine cycle (SRC) or a combined cycle, in which the SRC is the topping cycle and an organic Rankine cycle (ORC) is the bottoming cycle. Seven refrigerants for the ORC were examined: R134a, R152a, R290, R407c, R600, R600a, and ammonia. Key exergetic parameters were examined: exergetic efficiency, exergy destruction rate, fuel depletion ratio, irreversibility ratio, and improvement potential. For all the cases considered it was revealed that as the solar irradiation increases, the exergetic efficiency increases. Among the combined cycles examined, the R134a combined cycle demonstrates the best exergetic performance with a maximum exergetic efficiency of 26% followed by the R152a combined cycle with an exergetic efficiency of 25%. Alternatively, the R600a combined cycle has the lowest exergetic efficiency, 20–21%. This study reveals that the main source of exergy destruction is the solar collector where more than 50% of inlet exergy is destructed, or in other words more than 70% of the total destructed exergy. In addition, more than 13% of the inlet exergy is destructed in the evaporator which is equivalent to around 19% of the destructed exergy. Finally, this study reveals that there is an exergetic improvement potential of 75% in the systems considered

  19. Gas Classification Using Combined Features Based on a Discriminant Analysis for an Electronic Nose

    Directory of Open Access Journals (Sweden)

    Sang-Il Choi

    2016-01-01

    Full Text Available This paper proposes a gas classification method for an electronic nose (e-nose system, for which combined features that have been configured through discriminant analysis are used. First, each global feature is extracted from the entire measurement section of the data samples, while the same process is applied to the local features of the section that corresponds to the stabilization, exposure, and purge stages. The discriminative information amounts in the individual features are then measured based on the discriminant analysis, and the combined features are subsequently composed by selecting the features that have a large amount of discriminative information. Regarding a variety of volatile organic compound data, the results of the experiment show that, in a noisy environment, the proposed method exhibits classification performance that is relatively excellent compared to the other feature types.

  20. Meta analysis on clinical effectiveness of Chinese medicine physiotherapy combined with tropicamide eye drops for pseudomyopia

    Directory of Open Access Journals (Sweden)

    Dan Li

    2018-05-01

    Full Text Available AIM:To evaluate the curative effect of Chinese medicine physiotherapy combined with tropicamide eye drops to treat pseudomyopia in children and adolescent. METHODS: We collected randomized controlled trials from CNKI, CBM, Wanfang database, PubMed, EMBASE and Cochrane Library in 2000-2015, and the improved Jadad scale was used to evaluate the methodology of the literature, and the data was extracted. The Review Manager 5.3 statistical software was used for meta analysis. RESULTS: A total of 5 articles were included in the analysis, with a total sample size of 836 cases. The curative effect of experimental group on pseudomyopia was better than that of control group, and the differences are statistically significant(Z=6.39, PCONCLUSION: Compared with topiramine eye drops alone, combined with traditional Chinese medicine therapy for treating pseudomyopia in children and adolescent is more effective, and is safe and reliable.

  1. Combined slope ratio analysis and linear-subtraction: An extension of the Pearce ratio method

    Science.gov (United States)

    De Waal, Sybrand A.

    1996-07-01

    A new technique, called combined slope ratio analysis, has been developed by extending the Pearce element ratio or conserved-denominator method (Pearce, 1968) to its logical conclusions. If two stoichiometric substances are mixed and certain chemical components are uniquely contained in either one of the two mixing substances, then by treating these unique components as conserved, the composition of the substance not containing the relevant component can be accurately calculated within the limits allowed by analytical and geological error. The calculated composition can then be subjected to rigorous statistical testing using the linear-subtraction method recently advanced by Woronow (1994). Application of combined slope ratio analysis to the rocks of the Uwekahuna Laccolith, Hawaii, USA, and the lavas of the 1959-summit eruption of Kilauea Volcano, Hawaii, USA, yields results that are consistent with field observations.

  2. Basis of combined Pinch Technology and exergy analysis and its application to energy industry in Mexico

    International Nuclear Information System (INIS)

    Rodriguez T, M.A.; Rangel D, H.

    1994-01-01

    The energy industry scheme in Mexico has an enormous potential to do re adaptations with the intention of increase the efficiency in the use of energy. One of the most modern engineering tools to make such re adaptations consist in a suitable combination of analysis of exergy and Pinch technology. In this work, the basis of this new technology are presented, besides the potential areas of application in the Mexican energy industry are also considered. So then, it is shown that a combined analysis of exergy and Pinch technology (ACETP) is useful to analyze, in a conceptual and easy to understand way, systems that involve heat and power. The potential areas of application of ACETP are, cryogenic processes, power generation systems and cogeneration systems. (Author)

  3. Age estimation in forensic sciences: Application of combined aspartic acid racemization and radiocarbon analysis

    Energy Technology Data Exchange (ETDEWEB)

    Alkass, K; Buchholz, B A; Ohtani, S; Yamamoto, T; Druid, H; Spalding, S L

    2009-11-02

    Age determination of unknown human bodies is important in the setting of a crime investigation or a mass disaster, since the age at death, birth date and year of death, as well as gender, can guide investigators to the correct identity among a large number of possible matches. Traditional morphological methods used by anthropologists to determine age are often imprecise, whereas chemical analysis of tooth dentin, such as aspartic acid racemization has shown reproducible and more precise results. In this paper we analyze teeth from Swedish individuals using both aspartic acid racemization and radiocarbon methodologies. The rationale behind using radiocarbon analysis is that above-ground testing of nuclear weapons during the cold war (1955-1963) caused an extreme increase in global levels of carbon-14 ({sup 14}C) which have been carefully recorded over time. Forty-four teeth from 41 individuals were analyzed using aspartic acid racemization analysis of tooth crown dentin or radiocarbon analysis of enamel and ten of these were split and subjected to both radiocarbon and racemization analysis. Combined analysis showed that the two methods correlated well (R2=0.66, p < 0.05). Radiocarbon analysis showed an excellent precision with an overall absolute error of 0.6 {+-} 04 years. Aspartic acid racemization also showed a good precision with an overall absolute error of 5.4 {+-} 4.2 years. Whereas radiocarbon analysis gives an estimated year of birth, racemization analysis indicates the chronological age of the individual at the time of death. We show how these methods in combination can also assist in the estimation of date of death of an unidentified victim. This strategy can be of significant assistance in forensic casework involving dead victim identification.

  4. The impact of fixed-dose combination versus free-equivalent combination therapies on adherence for hypertension: a meta-analysis.

    Science.gov (United States)

    Du, Li-Ping; Cheng, Zhong-Wei; Zhang, Yu-Xuan; Li, Ying; Mei, Dan

    2018-04-27

    Nonadherence to antihypertensive medication is considered as a reason of inadequate control of blood pressure. This meta-analysis aimed to systemically evaluate the impact of fixed-dose combination (FDC) therapy on hypertensive medication adherence compared with free-equivalent combination therapies. Articles were retrieved from MEDLINE and Embase databases using a combination of terms "fixed-dose combinations" and "adherence or compliance or persistence" and "hypertension or antihypertensive" from January 2000 to June 2017 without any language restriction. A meta-analysis was performed to parallel compare the impact of FDC vs free-equivalent combination on medicine adherence or persistence. Studies were independently reviewed by two investigators. Data from eligible studies were extracted and a meta-analysis was performed using R version 3.1.0 software. A total of nine studies scored as six of nine to eight of nine for Newcastle-Ottawa rating with 62 481 patients with hypertension were finally included for analysis. Results showed that the mean difference of medication adherence for FDC vs free-equivalent combination therapies was 14.92% (95% confidence interval, 7.38%-22.46%). Patients in FDC group were more likely to persist with their antihypertensive treatment, with a risk ratio of 1.84 (95% confidence interval, 1.00-3.39). This meta-analysis confirmed that FDC therapy, compared with free-equivalent combinations, was associated with better medication adherence or persistence for patients with hypertension. It can be reasonable for physicians, pharmacists, and policy makers to facilitate the use of FDCs for patients who need to take two or more antihypertensive drugs. ©2018 Wiley Periodicals, Inc.

  5. Combining Conversation Analysis and Nexus Analysis to analyse sociomaterial and affective practices

    DEFF Research Database (Denmark)

    Raudaskoski, Pirkko Liisa

    2016-01-01

    of resemiotization (Iedema 2000). Within organization and design studies, materiality has become a focus in the increasingly popular sociomaterial approach to everyday practices (e.g. Orlikowski 2007). Some sociomaterial scholars (e.g. Sørensen 2013) analyse ethnographic data either as evidence for the sociomaterial....... The analytical effort is to get to the senses and sensations which are regarded as opposite of sense-making. In my presentation, I go through some of my own analyses from various institutional interactions to show how CA-based multimodal analyses of local interactional (or intra-actional) trajectories combined...... configuration, also as an interdisciplinary offer for an analytic package that might help sociomaterial researchers of practices come even closer to the situation at hand as an assemblage out of which materials, humans and experiences emerge....

  6. Preliminary spatial analysis of combined BATSE/Ulysses gamma-ray burst locations

    International Nuclear Information System (INIS)

    Kippen, R. Marc; Hurley, Kevin; Pendleton, Geoffrey N.

    1998-01-01

    We present the preliminary spatial analysis of 278 bursts that have been localized by BATSE and the two-spacecraft Compton/Ulysses Interplanetary Network. The large number and superior accuracy of the combined BATSE/Ulysses locations provides improved sensitivity to small-angle source properties. We find that the locations are consistent with large- and small-scale isotropy, with no significant small-angle clustering. We constrain the fraction of sources in clusters and discuss the implications for burst repetition

  7. Meta analysis on clinical effectiveness of Chinese medicine physiotherapy combined with tropicamide eye drops for pseudomyopia

    OpenAIRE

    Dan Li; Ling Shen; En-Li Deng

    2018-01-01

    AIM:To evaluate the curative effect of Chinese medicine physiotherapy combined with tropicamide eye drops to treat pseudomyopia in children and adolescent. METHODS: We collected randomized controlled trials from CNKI, CBM, Wanfang database, PubMed, EMBASE and Cochrane Library in 2000-2015, and the improved Jadad scale was used to evaluate the methodology of the literature, and the data was extracted. The Review Manager 5.3 statistical software was used for meta analysis. RESULTS: A total of 5...

  8. Technical Analysis of Combined Solar Water Heating Systems for Cold Climate Regions

    OpenAIRE

    Hossein Lotfizadeh; André McDonald; Amit Kumar

    2016-01-01

    Renewable energy resources, which can supplement space and water heating for residential buildings, can have a noticeable impact on natural gas consumption and air pollution. This study considers a technical analysis of a combined solar water heating system with evacuated tube solar collectors for different solar coverage, ranging from 20% to 100% of the total roof area of a typical residential building located in Edmonton, Alberta, Canada. The alternative heating systems were conventional (n...

  9. Combined PIXE and XPS analysis on republican and imperial Roman coins

    International Nuclear Information System (INIS)

    Dacca, A.; Prati, P.; Zucchiatti, A.; Lucarelli, F.; Mando, P.A.; Gemme, G.; Parodi, R.; Pera, R.

    2000-01-01

    A combined PIXE and XPS analysis has been performed on a few Roman coins of the republican and imperial age. The purpose was to investigate via XPS the nature and extent of patina in order to be capable of extracting PIXE data relative to the coins bulk. The inclusion of elements from the surface layer, altered by oxidation and inclusion, is a known source of uncertainty in PIXE analyses of coins, performed to assess the composition and the provenance

  10. Proceedings of the specialist research meeting on 'the latest study on analysis of trace amount of elements using activation analysis and the results and future prospects of activation analysis using KUR'

    International Nuclear Information System (INIS)

    Ebihara, Mitsuru; Shibata, Seiichi; Sekimoto, Shun

    2014-01-01

    This Specialist Research Meeting report is the summary of the lectures that were delivered at the Specialist Research Meeting of Kyoto University Reactor Research Institute on January 25, 2013 and October 30, 2013. These meetings were held under the subtitles of 'Current state of trace element analysis using activation analysis' and 'Achievements and future prospects of activation analysis using Kyoto University research reactor (KUR)', respectively. At the former meeting, 14 speeches were delivered including the following: (1) introduction of Australia Nuclear Science and Technology Organisation (ANSTO), (2) determination of element concentration in the hairs in frequent ALS (amyotrophic lateral sclerosis) occurrence zones, (3) effects of vegetation on the acid neutralizing capacity of soil, (4) activation analysis of geological samples, and (5) current situation of KUR. At the latter meeting, 15 speeches were delivered including the following: (1) neutron activation analysis of iron meteorites and Chinese herbal medicines / herbs, (2) neutron activation analysis at KUR using IAEA-k0 method, (3) current state of KUR, (4) development and applications of automatic prompt gamma-ray analysis equipment. (A.O.)

  11. An MGF-based capacity analysis of equal gain combining over fading channels

    KAUST Repository

    Yilmaz, Ferkan

    2010-09-01

    Exact average capacity results for L-branch coherent equal-gain combining (EGC) in correlated and uncorrelated fading channels are not known. This paper develops a novel framework (approach) for capacity analysis of L-branch EGC in generalized fading channels. In addition, Gamma shadowed generalized Nakagami-m fading model is proposed in order to statistically model the fading environments in high frequencies such as 60 GHz and above. Some simulations are carried out and then the obtained results are accentuated by means of numerical analysis based on the proposed framework. Numerical and simulation results, performed to verify the correctness of the proposed framework, are in perfect agreement. ©2010 IEEE.

  12. [Forensic entomology exemplified by a homicide. A combined stain and postmortem time analysis].

    Science.gov (United States)

    Benecke, M; Seifert, B

    1999-01-01

    The combined analysis of both ant and blow fly evidence recovered from a corpse, and from the boot of a suspect, suggested that an assumed scenario in a high profile murder case was likely to be true. The ants (Lasius fuliginous) were used as classical crime scene stains that linked the suspect to the scene. Blow fly maggots (Calliphora spec.) helped to determine the post mortem interval (PMI) with the calculated PMI overlapping with the assumed time of the killing. In the trial, the results of the medico-legal analysis of the insects was understood to be crucial scientific evidence, and the suspect was sentenced to 8 years in prison.

  13. An MGF-based capacity analysis of equal gain combining over fading channels

    KAUST Repository

    Yilmaz, Ferkan; Alouini, Mohamed-Slim

    2010-01-01

    Exact average capacity results for L-branch coherent equal-gain combining (EGC) in correlated and uncorrelated fading channels are not known. This paper develops a novel framework (approach) for capacity analysis of L-branch EGC in generalized fading channels. In addition, Gamma shadowed generalized Nakagami-m fading model is proposed in order to statistically model the fading environments in high frequencies such as 60 GHz and above. Some simulations are carried out and then the obtained results are accentuated by means of numerical analysis based on the proposed framework. Numerical and simulation results, performed to verify the correctness of the proposed framework, are in perfect agreement. ©2010 IEEE.

  14. Probability problems in seismic risk analysis and load combinations for nuclear power plants

    International Nuclear Information System (INIS)

    George, L.L.

    1983-01-01

    This workshop describes some probability problems in power plant reliability and maintenance analysis. The problems are seismic risk analysis, loss of load probability, load combinations, and load sharing. The seismic risk problem is to compute power plant reliability given an earthquake and the resulting risk. Component survival occurs if its peak random response to the earthquake does not exceed its strength. Power plant survival is a complicated Boolean function of component failures and survivals. The responses and strengths of components are dependent random processes, and the peak responses are maxima of random processes. The resulting risk is the expected cost of power plant failure

  15. A study on quantifying COPD severity by combining pulmonary function tests and CT image analysis

    Science.gov (United States)

    Nimura, Yukitaka; Kitasaka, Takayuki; Honma, Hirotoshi; Takabatake, Hirotsugu; Mori, Masaki; Natori, Hiroshi; Mori, Kensaku

    2011-03-01

    This paper describes a novel method that can evaluate chronic obstructive pulmonary disease (COPD) severity by combining measurements of pulmonary function tests and measurements obtained from CT image analysis. There is no cure for COPD. However, with regular medical care and consistent patient compliance with treatments and lifestyle changes, the symptoms of COPD can be minimized and progression of the disease can be slowed. Therefore, many diagnosis methods based on CT image analysis have been proposed for quantifying COPD. Most of diagnosis methods for COPD extract the lesions as low-attenuation areas (LAA) by thresholding and evaluate the COPD severity by calculating the LAA in the lung (LAA%). However, COPD is usually the result of a combination of two conditions, emphysema and chronic obstructive bronchitis. Therefore, the previous methods based on only LAA% do not work well. The proposed method utilizes both of information including the measurements of pulmonary function tests and the results of the chest CT image analysis to evaluate the COPD severity. In this paper, we utilize a multi-class AdaBoost to combine both of information and classify the COPD severity into five stages automatically. The experimental results revealed that the accuracy rate of the proposed method was 88.9% (resubstitution scheme) and 64.4% (leave-one-out scheme).

  16. Spectral Quantitative Analysis Model with Combining Wavelength Selection and Topology Structure Optimization

    Directory of Open Access Journals (Sweden)

    Qian Wang

    2016-01-01

    Full Text Available Spectroscopy is an efficient and widely used quantitative analysis method. In this paper, a spectral quantitative analysis model with combining wavelength selection and topology structure optimization is proposed. For the proposed method, backpropagation neural network is adopted for building the component prediction model, and the simultaneousness optimization of the wavelength selection and the topology structure of neural network is realized by nonlinear adaptive evolutionary programming (NAEP. The hybrid chromosome in binary scheme of NAEP has three parts. The first part represents the topology structure of neural network, the second part represents the selection of wavelengths in the spectral data, and the third part represents the parameters of mutation of NAEP. Two real flue gas datasets are used in the experiments. In order to present the effectiveness of the methods, the partial least squares with full spectrum, the partial least squares combined with genetic algorithm, the uninformative variable elimination method, the backpropagation neural network with full spectrum, the backpropagation neural network combined with genetic algorithm, and the proposed method are performed for building the component prediction model. Experimental results verify that the proposed method has the ability to predict more accurately and robustly as a practical spectral analysis tool.

  17. Structural Integrity Analysis considered Load Combination for the Conceptual Design of Korean HCCR TBM-set

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Dong Won; Jin, Hyung Gon; Lee, Eo Hwak; Yoon, Jae Sung; Kim, Suk Kwon [KAERI, Daejeon (Korea, Republic of); Shin, Kyu In [Gentec Tech, Daejeon (Korea, Republic of); Cho, Seungyon [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2015-05-15

    HCCR TBM (Test Blanket Module) set is consist of 4-TBM sub module, one blanket manifold (BM), a shield, and 4-key, which has a function of a connection between BM and the shield. And it shall be installed in the equatorial port No.18 of ITER inside the vacuum vessel directly facing the plasma and shall be cooled by a high-temperature helium coolant. In addition, the HCCR TBM-set safety classification follows the ITER (international thermonuclear reactor) safety importance class (SIC) criteria, and satisfies a design requirement according to RCC-MRx. In this study, some of load combination (LC) analysis for the structure integrity of TBM set were carried out based on the reference. And the LC results showed that they satisfied the design requirement. The material of TBM-set was used from the reference, and RCC-MRx for the stress analysis. In this study, the load combination results were met a design requirement. But some load combination case gave a higher maximum stress value than a design requirement and in these case the stress breakdown analysis according to RCC-MRx was performed, and the result were satisfied the design requirement.

  18. Theoretical analysis of a combined power and ejector refrigeration cycle using zeotropic mixture

    International Nuclear Information System (INIS)

    Yang, Xingyang; Zhao, Li; Li, Hailong; Yu, Zhixin

    2015-01-01

    Highlights: • A combined power and refrigeration cycle using zeotropic mixture is analyzed. • The cycle performances with different mixture compositions are compared. • Both exergy and parametric analysis of the combined cycle are conducted. - Abstract: A theoretical study on a combined power and ejector refrigeration cycle using zeotropic mixture isobutane/pentane is carried out. The performances of different mixture compositions are compared. An exergy analysis is conducted for the cycle. The result reveals that most exergy destruction happens in the ejector, where more than 40% exergy is lost. The heat exchange in generator causes the second largest exergy loss, larger than 28%. As the mass fraction of isobutane changes ranges from 100% to 0%, the relative exergy destruction of each component is also changing. And mixture isobutane/pentane (50/50) has the maximum exergy efficiency of 7.83%. The parametric analysis of generator temperature, condenser temperature and evaporator temperature for all the mixtures shows that, all these three thermodynamic parameters have a strong effect on the cycle performance.

  19. Combined analysis of the S and W parameters obtained from positron annihilation spectra

    International Nuclear Information System (INIS)

    Fedorov, A.V.; Veen, A. van; Schut, H.

    2001-01-01

    Variable energy positron beam analysis (PBA) has proven to be a very useful and powerful technique for the study of nanosize layer structures and point defects in various materials. Analysis of the positron annihilation spectra is usually performed with the help of the S and W parameters. By mapping the experimental points in the S-W plane the cluster points characteristic for the layers or defects can be derived. We have developed the program SWAN (S-W analysis) to enable to trace these cluster points and to calculate the fractions of the positrons annihilated at the layers or defects ascribed to the cluster points. In combination with the known computer code VEPFIT, program SWAN was successfully used for analyzing the S and W- curves for a number of samples. As an example, the analysis of SIMOX sample measured by PBA is presented. The program runs on a PC, has a user-friendly interface and is available for distribution. (orig.)

  20. Hair analysis to monitor abuse of analgesic combinations containing butalbital and propyphenazone.

    Science.gov (United States)

    Ferrari, Anna; Tiraferri, Ilaria; Palazzoli, Federica; Verri, Patrizia; Vandelli, Daniele; Marchesi, Filippo; Ciccarese, Michela; Licata, Manuela

    2015-11-10

    Butalbital, a barbiturate, is present in analgesic combinations used by headache sufferers. Overuse/abuse of these combinations may cause dependence, chronic migraine, and medication-overuse headache (MOH). MOH is difficult to manage: it improves interrupting analgesic overuse, but requires monitoring, because relapses are frequent. A gas chromatography-mass spectrometry (GC-MS) method for hair analysis has been developed and validated to document abuse of an analgesic combination containing butalbital and propyphenazone by a patient with MOH. For over ten years the patient managed her headache using eight suppositories/day of an analgesic combination containing butalbital 150mg, caffeine 75mg, and propyphenazone 375mg per suppository. An outpatient detoxification treatment was carried out. After three weeks, the patient reduced the consumption to one suppository/day. At the first control visit, after three months from the beginning of detoxification, the patient increased the use of the combination to four suppositories/day and at the second control visit, after seven months from the beginning of detoxification, she was back to eight suppositories/day. At the two control visits, a hair sample was taken for determination of butalbital and propyphenazone. Moreover blood and urine samples for determination of butalbital were drawn at the beginning of detoxification treatment and at the two control visits. With the segmental analysis of two hair samples the medication history of ten months could be estimated. In the first hair sample, collected at the first control visit, in the distal segment, butalbital and propyphenazone concentrations were, respectively, 17.5ng/mg and 56.0ng/mg, confirming the prolonged abuse; in the proximal segment, concurrently with the detoxification treatment, butalbital and propyphenazone concentrations had reduced respectively to 5.45ng/mg and 11.1ng/mg. The second hair sample, collected at the second control visit, proved the fair course

  1. Combination of material flow analysis and substance flow analysis: a powerful approach for decision support in waste management.

    Science.gov (United States)

    Stanisavljevic, Nemanja; Brunner, Paul H

    2014-08-01

    The novelty of this paper is the demonstration of the effectiveness of combining material flow analysis (MFA) with substance flow analysis (SFA) for decision making in waste management. Both MFA and SFA are based on the mass balance principle. While MFA alone has been applied often for analysing material flows quantitatively and hence to determine the capacities of waste treatment processes, SFA is more demanding but instrumental in evaluating the performance of a waste management system regarding the goals "resource conservation" and "environmental protection". SFA focuses on the transformations of wastes during waste treatment: valuable as well as hazardous substances and their transformations are followed through the entire waste management system. A substance-based approach is required because the economic and environmental properties of the products of waste management - recycling goods, residues and emissions - are primarily determined by the content of specific precious or harmful substances. To support the case that MFA and SFA should be combined, a case study of waste management scenarios is presented. For three scenarios, total material flows are quantified by MFA, and the mass flows of six indicator substances (C, N, Cl, Cd, Pb, Hg) are determined by SFA. The combined results are compared to the status quo in view of fulfilling the goals of waste management. They clearly point out specific differences between the chosen scenarios, demonstrating potentials for improvement and the value of the combination of MFA/SFA for decision making in waste management. © The Author(s) 2014.

  2. Age estimation in forensic sciences: application of combined aspartic acid racemization and radiocarbon analysis.

    Science.gov (United States)

    Alkass, Kanar; Buchholz, Bruce A; Ohtani, Susumu; Yamamoto, Toshiharu; Druid, Henrik; Spalding, Kirsty L

    2010-05-01

    Age determination of unknown human bodies is important in the setting of a crime investigation or a mass disaster because the age at death, birth date, and year of death as well as gender can guide investigators to the correct identity among a large number of possible matches. Traditional morphological methods used by anthropologists to determine age are often imprecise, whereas chemical analysis of tooth dentin, such as aspartic acid racemization, has shown reproducible and more precise results. In this study, we analyzed teeth from Swedish individuals using both aspartic acid racemization and radiocarbon methodologies. The rationale behind using radiocarbon analysis is that aboveground testing of nuclear weapons during the cold war (1955-1963) caused an extreme increase in global levels of carbon-14 ((14)C), which has been carefully recorded over time. Forty-four teeth from 41 individuals were analyzed using aspartic acid racemization analysis of tooth crown dentin or radiocarbon analysis of enamel, and 10 of these were split and subjected to both radiocarbon and racemization analysis. Combined analysis showed that the two methods correlated well (R(2) = 0.66, p Aspartic acid racemization also showed a good precision with an overall absolute error of 5.4 +/- 4.2 years. Whereas radiocarbon analysis gives an estimated year of birth, racemization analysis indicates the chronological age of the individual at the time of death. We show how these methods in combination can also assist in the estimation of date of death of an unidentified victim. This strategy can be of significant assistance in forensic casework involving dead victim identification.

  3. Dynamic and Static Combination Analysis Method of Slope Stability Analysis during Earthquake

    OpenAIRE

    Liang Lu; Zongjian Wang; Xiaoyuan Huang; Bin Zheng; Katsuhiko Arai

    2014-01-01

    The results of laboratory model tests for simulating the slope failure due to vibration, including unreinforced slope and the slope reinforced by using geotextile, show that the slope failure occurs when a cumulative plastic displacement exceeds a certain critical value. To overcome the defects of conventional stability analysis, which evaluates the slope characteristics only by its strength parameters, a numerical procedure considering the stiffness and deformation of materials and geosynthe...

  4. Expediting Combinatorial Data Set Analysis by Combining Human and Algorithmic Analysis.

    Science.gov (United States)

    Stein, Helge Sören; Jiao, Sally; Ludwig, Alfred

    2017-01-09

    A challenge in combinatorial materials science remains the efficient analysis of X-ray diffraction (XRD) data and its correlation to functional properties. Rapid identification of phase-regions and proper assignment of corresponding crystal structures is necessary to keep pace with the improved methods for synthesizing and characterizing materials libraries. Therefore, a new modular software called htAx (high-throughput analysis of X-ray and functional properties data) is presented that couples human intelligence tasks used for "ground-truth" phase-region identification with subsequent unbiased verification by an algorithm to efficiently analyze which phases are present in a materials library. Identified phases and phase-regions may then be correlated to functional properties in an expedited manner. For the functionality of htAx to be proven, two previously published XRD benchmark data sets of the materials systems Al-Cr-Fe-O and Ni-Ti-Cu are analyzed by htAx. The analysis of ∼1000 XRD patterns takes less than 1 day with htAx. The proposed method reliably identifies phase-region boundaries and robustly identifies multiphase structures. The method also addresses the problem of identifying regions with previously unpublished crystal structures using a special daisy ternary plot.

  5. Combining SPECT and Quantitative EEG Analysis for the Automated Differential Diagnosis of Disorders with Amnestic Symptoms

    Directory of Open Access Journals (Sweden)

    Yvonne Höller

    2017-09-01

    Full Text Available Single photon emission computed tomography (SPECT and Electroencephalography (EEG have become established tools in routine diagnostics of dementia. We aimed to increase the diagnostic power by combining quantitative markers from SPECT and EEG for differential diagnosis of disorders with amnestic symptoms. We hypothesize that the combination of SPECT with measures of interaction (connectivity in the EEG yields higher diagnostic accuracy than the single modalities. We examined 39 patients with Alzheimer's dementia (AD, 69 patients with depressive cognitive impairment (DCI, 71 patients with amnestic mild cognitive impairment (aMCI, and 41 patients with amnestic subjective cognitive complaints (aSCC. We calculated 14 measures of interaction from a standard clinical EEG-recording and derived graph-theoretic network measures. From regional brain perfusion measured by 99mTc-hexamethyl-propylene-aminoxime (HMPAO-SPECT in 46 regions, we calculated relative cerebral perfusion in these patients. Patient groups were classified pairwise with a linear support vector machine. Classification was conducted separately for each biomarker, and then again for each EEG- biomarker combined with SPECT. Combination of SPECT with EEG-biomarkers outperformed single use of SPECT or EEG when classifying aSCC vs. AD (90%, aMCI vs. AD (70%, and AD vs. DCI (100%, while a selection of EEG measures performed best when classifying aSCC vs. aMCI (82% and aMCI vs. DCI (90%. Only the contrast between aSCC and DCI did not result in above-chance classification accuracy (60%. In general, accuracies were higher when measures of interaction (i.e., connectivity measures were applied directly than when graph-theoretical measures were derived. We suggest that quantitative analysis of EEG and machine-learning techniques can support differentiating AD, aMCI, aSCC, and DCC, especially when being combined with imaging methods such as SPECT. Quantitative analysis of EEG connectivity could become

  6. The Combination of Coastal Resources Potential: Development of Windmill Techno Park in the Context of Edutourism and Hinterland Analysis

    Science.gov (United States)

    Hasanuddin, H.; Nurdin, H.; Waskito, W.; Refdinal, R.

    2018-04-01

    There are many coastal cities in Indonesia, among them the city of Padang and Pariaman in West Sumatra with the ownership of the grace of coastal resources, such as stunning coastal scenery and wind energy that can be converted to its potential. These two types of resources need to be combined utilization especially in relation to the development of tourism so as to have an impact on the regional development and the cities growth. This paper discusses of information related to the potential of coastal resources used as a parameter development of windmill techno park in the context of educational tourism. The discussion focuses on locational aspects and consideration of the design and modification for the windmill model to the enhancement of tourist attraction. In addition, it is also studying the presence of the windmill techno park as a development center in the context of hinterland in the regional analysis. Through the measurement results obtained average wind speed (2.5 - 6.5) m/s and meet the standards & criteria as a windmill design variables. While the geomorphology of the region, its location has a breathtaking coastal landscape as a tourist destination. Then through gravity analysis, the location of the windmill techno park development provides optimum strength to the growth of the city of Padang, with the value of interaction strength is higher than other regions. This means as a sub-urban area of the city the existence of windshield techno park later can support economic development and growth of cities around the coast.

  7. Discovery of Acupoints and Combinations with Potential to Treat Vascular Dementia: A Data Mining Analysis

    Directory of Open Access Journals (Sweden)

    Shuwei Feng

    2015-01-01

    Full Text Available The prevalence of vascular dementia (VaD is high among the elderly. Acupuncture, a popular therapeutic method in China, can improve memory, orientation, calculation, and self-managing ability in VaD patients. However, in clinical acupuncture and acupuncture research, the selection of acupoints to treat VaD remains challenging. This study aimed to discover acupoints and acupoint combinations with potential for VaD based on data mining. After database searching and screening for articles on clinical trials evaluating the effects of acupuncture on VaD, 238 acupuncture prescriptions were included for further analysis. Baihui (GV 20, Sishencong (EX-HN 1, Fengchi (GB 20, Shuigou (GV 26, and Shenting (GV 24 appeared most frequently in the modern literature and are potential acupoints for VaD. Combinations between Baihui (GV 20, Sishencong (EX-HN 1, Fengchi (GB 20, Shenting (GV 24, Shuigou (GV 26, and Zusanli (ST 36 were most frequent and represent potential combinations for VaD treatment. These results provide a reference for the selection and combination of acupoints to treat VaD in clinical acupuncture and acupuncture research.

  8. A combined dynamic analysis method for geometrically nonlinear vibration isolators with elastic rings

    Science.gov (United States)

    Hu, Zhan; Zheng, Gangtie

    2016-08-01

    A combined analysis method is developed in the present paper for studying the dynamic properties of a type of geometrically nonlinear vibration isolator, which is composed of push-pull configuration rings. This method combines the geometrically nonlinear theory of curved beams and the Harmonic Balance Method to overcome the difficulty in calculating the vibration and vibration transmissibility under large deformations of the ring structure. Using the proposed method, nonlinear dynamic behaviors of this isolator, such as the lock situation due to the coulomb damping and the usual jump resulting from the nonlinear stiffness, can be investigated. Numerical solutions based on the primary harmonic balance are first verified by direct integration results. Then, the whole procedure of this combined analysis method is demonstrated and validated by slowly sinusoidal sweeping experiments with different amplitudes of the base excitation. Both numerical and experimental results indicate that this type of isolator behaves as a hardening spring with increasing amplitude of the base excitation, which makes it suitable for isolating both steady-state vibrations and transient shocks.

  9. Combined analysis of magnetic and gravity anomalies using normalized source strength (NSS)

    Science.gov (United States)

    Li, L.; Wu, Y.

    2017-12-01

    Gravity field and magnetic field belong to potential fields which lead inherent multi-solution. Combined analysis of magnetic and gravity anomalies based on Poisson's relation is used to determinate homology gravity and magnetic anomalies and decrease the ambiguity. The traditional combined analysis uses the linear regression of the reduction to pole (RTP) magnetic anomaly to the first order vertical derivative of the gravity anomaly, and provides the quantitative or semi-quantitative interpretation by calculating the correlation coefficient, slope and intercept. In the calculation process, due to the effect of remanent magnetization, the RTP anomaly still contains the effect of oblique magnetization. In this case the homology gravity and magnetic anomalies display irrelevant results in the linear regression calculation. The normalized source strength (NSS) can be transformed from the magnetic tensor matrix, which is insensitive to the remanence. Here we present a new combined analysis using NSS. Based on the Poisson's relation, the gravity tensor matrix can be transformed into the pseudomagnetic tensor matrix of the direction of geomagnetic field magnetization under the homologous condition. The NSS of pseudomagnetic tensor matrix and original magnetic tensor matrix are calculated and linear regression analysis is carried out. The calculated correlation coefficient, slope and intercept indicate the homology level, Poisson's ratio and the distribution of remanent respectively. We test the approach using synthetic model under complex magnetization, the results show that it can still distinguish the same source under the condition of strong remanence, and establish the Poisson's ratio. Finally, this approach is applied in China. The results demonstrated that our approach is feasible.

  10. Constraining processes of landscape change with combined in situ cosmogenic 14C-10Be analysis

    Science.gov (United States)

    Hippe, Kristina

    2017-10-01

    Reconstructing Quaternary landscape evolution today frequently builds upon cosmogenic-nuclide surface exposure dating. However, the study of complex surface exposure chronologies on the 102-104 years' timescale remains challenging with the commonly used long-lived radionuclides (10Be, 26Al, 36Cl). In glacial settings, key points are the inheritance of nuclides accumulated in a rock surface during a previous exposure episode and (partial) shielding of a rock surface after the main deglaciation event, e.g. during phases of glacier readvance. Combining the short-lived in situ cosmogenic 14C isotope with 10Be dating provides a valuable approach to resolve and quantify complex exposure histories and burial episodes within Lateglacial and Holocene timescales. The first studies applying the in situ14C-10Be pair have demonstrated the great benefit from in situ14C analysis for unravelling complex glacier chronologies in various glacial environments worldwide. Moreover, emerging research on in situ14C in sedimentary systems highlights the capacity of combined in situ14C-10Be analysis to quantify sediment transfer times in fluvial catchments or to constrain changes in surface erosion rates. Nevertheless, further methodological advances are needed to obtain truly routine and widely available in situ14C analysis. Future development in analytical techniques has to focus on improving the analytical reproducibility, reducing the background level and determining more accurate muonic production rates. These improvements should allow extending the field of applications for combined in situ14C-10Be analysis in Earth surface sciences and open up a number of promising applications for dating young sedimentary deposits and the quantification of recent changes in surface erosion dynamics.

  11. Analysis Method of Combine Harvesters Technical Level by Functional and Structural Parameters

    Directory of Open Access Journals (Sweden)

    E. V. Zhalnin

    2018-01-01

    Full Text Available The analysis of modern methods of evaluation of the grain harvesters technical level revealed a discrepancy in various criteria: comparative parameters, dimensionless series, the names of firms, the power of the motor, the width of the capture of the harvester, the capacity at the location of the manufacturer plant, advertising brands. (Purpose of research This led to a variety in the name of harvester models, which significantly complicates the assessment of their technical level, complicates the choice of agricultural necessary to him fashion, does not give the perception of the continuity of the change of generations of combines, makes it impossible to analyze trends in their development, does not disclose the technological essence of a model, but - most importantly - combines can not be compared with each other. The figures in the name of the harvester model are not related functionally to the main parameters and performance capabilities. (Materials and methods The close correlation in the form of a linear equation between their design parameters and the capacity of combines was revealed. Verification of this equation in the process of operation of the combine showed that it statistically stable and the estimates are always within the confidence interval with an error of 5-8 percent. It was found that four parameters of the variety of factors, that affect the performance of the harvester per hour net time, having most close correlation with it are: the motor power and the square of the separation concave, straw walkers and sieves for cleaning. (Results and discussion On the basis of the revealed correlation dependence we proposed a new method of assessment of the technical level of combines, which is based on the throughput (kg/s of the wetted material and the size series, indicating the nominal productivity of the combine in centners of grain harvested in 1 hour of basic time. The methodological background and mathematical apparatus

  12. Meta-analysis methods for combining multiple expression profiles: comparisons, statistical characterization and an application guideline.

    Science.gov (United States)

    Chang, Lun-Ching; Lin, Hui-Min; Sibille, Etienne; Tseng, George C

    2013-12-21

    As high-throughput genomic technologies become accurate and affordable, an increasing number of data sets have been accumulated in the public domain and genomic information integration and meta-analysis have become routine in biomedical research. In this paper, we focus on microarray meta-analysis, where multiple microarray studies with relevant biological hypotheses are combined in order to improve candidate marker detection. Many methods have been developed and applied in the literature, but their performance and properties have only been minimally investigated. There is currently no clear conclusion or guideline as to the proper choice of a meta-analysis method given an application; the decision essentially requires both statistical and biological considerations. We performed 12 microarray meta-analysis methods for combining multiple simulated expression profiles, and such methods can be categorized for different hypothesis setting purposes: (1) HS(A): DE genes with non-zero effect sizes in all studies, (2) HS(B): DE genes with non-zero effect sizes in one or more studies and (3) HS(r): DE gene with non-zero effect in "majority" of studies. We then performed a comprehensive comparative analysis through six large-scale real applications using four quantitative statistical evaluation criteria: detection capability, biological association, stability and robustness. We elucidated hypothesis settings behind the methods and further apply multi-dimensional scaling (MDS) and an entropy measure to characterize the meta-analysis methods and data structure, respectively. The aggregated results from the simulation study categorized the 12 methods into three hypothesis settings (HS(A), HS(B), and HS(r)). Evaluation in real data and results from MDS and entropy analyses provided an insightful and practical guideline to the choice of the most suitable method in a given application. All source files for simulation and real data are available on the author's publication website.

  13. MassTRIX reloaded: combined analysis and visualization of transcriptome and metabolome data.

    Directory of Open Access Journals (Sweden)

    Brigitte Wägele

    Full Text Available Systems Biology is a field in biological science that focuses on the combination of several or all "omics"-approaches in order to find out how genes, transcripts, proteins and metabolites act together in the network of life. Metabolomics as analog to genomics, transcriptomics and proteomics is more and more integrated into biological studies and often transcriptomic and metabolomic experiments are combined in one setup. At a first glance both data types seem to be completely different, but both produce information on biological entities, either transcripts or metabolites. Both types can be overlaid on metabolic pathways to obtain biological information on the studied system. For the joint analysis of both data types the MassTRIX webserver was updated. MassTRIX is freely available at www.masstrix.org.

  14. Thermodynamic analysis and conceptual design for partial coal gasification air preheating coal-fired combined cycle

    Science.gov (United States)

    Xu, Yue; Wu, Yining; Deng, Shimin; Wei, Shirang

    2004-02-01

    The partial coal gasification air pre-heating coal-fired combined cycle (PGACC) is a cleaning coal power system, which integrates the coal gasification technology, circulating fluidized bed technology, and combined cycle technology. It has high efficiency and simple construction, and is a new selection of the cleaning coal power systems. A thermodynamic analysis of the PGACC is carried out. The effects of coal gasifying rate, pre-heating air temperature, and coal gas temperature on the performances of the power system are studied. In order to repower the power plant rated 100 MW by using the PGACC, a conceptual design is suggested. The computational results show that the PGACC is feasible for modernizing the old steam power plants and building the new cleaning power plants.

  15. Supplement to proceedings of the second analysis meeting on JUPITER Program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1981-10-01

    This document provides a supplement to the proceedings which provided an analysis of the JUPITER Experiment in ZPPR-10 (including ZPPR-9). The Addendum and Comments discusses Reaction Rate Ratio and Distribution. Topics provided are: Some Additional Corrections for ZPPR-9 Reaction Rate Distribution; An Analysis of the Sample Worth Experiments in ZPPR-10A; Homogenization Method of Pin Rods in ZPPR- 10A Assembly; and Control Rod Analysis in ZPPR-3.

  16. Performance analysis of an Integrated Solar Combined Cycle using Direct Steam Generation in parabolic trough collectors

    International Nuclear Information System (INIS)

    Montes, M.J.; Rovira, A.; Munoz, M.; Martinez-Val, J.M.

    2011-01-01

    Highlights: → Solar hybridization improves the performance of CCGT in a very hot and dry weather. → The scheme analyzed is a DSG parabolic trough field coupled to the Rankine cycle. → An annual simulation has been carried out for two locations: Almeria and Las Vegas. → Economical analysis shows that this scheme is a cheaper way to exploit solar energy. → For that, solar hybridization must be limited to a small fraction of the CCGT power. - Abstract: The contribution of solar thermal power to improve the performance of gas-fired combined cycles in very hot and dry environmental conditions is analyzed in this work, in order to assess the potential of this technique, and to feature Direct Steam Generation (DSG) as a well suited candidate for achieving very good results in this quest. The particular Integrated Solar Combined Cycle (ISCC) power plant proposed consists of a DSG parabolic trough field coupled to the bottoming steam cycle of a Combined Cycle Gas Turbine (CCGT) power plant. For this analysis, the solar thermal power plant performs in a solar dispatching mode: the gas turbine always operates at full load, only depending on ambient conditions, whereas the steam turbine is somewhat boosted to accommodate the thermal hybridization from the solar field. Although the analysis is aimed to studying such complementary effects in the widest perspective, two relevant examples are given, corresponding to two well-known sites: Almeria (Spain), with a mediterranean climate, and Las Vegas (USA), with a hot and dry climate. The annual simulations show that, although the conventional CCGT power plant works worse in Las Vegas, owing to the higher temperatures, the ISCC system operates better in Las Vegas than in Almeria, because of solar hybridization is especially well coupled to the CCGT power plant in the frequent days with great solar radiation and high temperatures in Las Vegas. The complementary effect will be clearly seen in these cases, because the thermal

  17. MOVES sensitivity analysis update : Transportation Research Board Summer Meeting 2012 : ADC-20 Air Quality Committee

    Science.gov (United States)

    2012-01-01

    OVERVIEW OF PRESENTATION : Evaluation Parameters : EPAs Sensitivity Analysis : Comparison to Baseline Case : MOVES Sensitivity Run Specification : MOVES Sensitivity Input Parameters : Results : Uses of Study

  18. Glycomics meets artificial intelligence - Potential of glycan analysis for identification of seropositive and seronegative rheumatoid arthritis patients revealed.

    Science.gov (United States)

    Chocholova, Erika; Bertok, Tomas; Jane, Eduard; Lorencova, Lenka; Holazova, Alena; Belicka, Ludmila; Belicky, Stefan; Mislovicova, Danica; Vikartovska, Alica; Imrich, Richard; Kasak, Peter; Tkac, Jan

    2018-06-01

    In this study, one hundred serum samples from healthy people and patients with rheumatoid arthritis (RA) were analyzed. Standard immunoassays for detection of 10 different RA markers and analysis of glycan markers on antibodies in 10 different assay formats with several lectins were applied for each serum sample. A dataset containing 2000 data points was data mined using artificial neural networks (ANN). We identified key RA markers, which can discriminate between healthy people and seropositive RA patients (serum containing autoantibodies) with accuracy of 83.3%. Combination of RA markers with glycan analysis provided much better discrimination accuracy of 92.5%. Immunoassays completely failed to identify seronegative RA patients (serum not containing autoantibodies), while glycan analysis correctly identified 43.8% of these patients. Further, we revealed other critical parameters for successful glycan analysis such as type of a sample, format of analysis and orientation of captured antibodies for glycan analysis. Copyright © 2018 Elsevier B.V. All rights reserved.

  19. Analysis of combination drug therapy to develop regimens with shortened duration of treatment for tuberculosis.

    Directory of Open Access Journals (Sweden)

    George L Drusano

    Full Text Available Tuberculosis remains a worldwide problem, particularly with the advent of multi-drug resistance. Shortening therapy duration for Mycobacterium tuberculosis is a major goal, requiring generation of optimal kill rate and resistance-suppression. Combination therapy is required to attain the goal of shorter therapy.Our objective was to identify a method for identifying optimal combination chemotherapy. We developed a mathematical model for attaining this end. This is accomplished by identifying drug effect interaction (synergy, additivity, antagonism for susceptible organisms and subpopulations resistant to each drug in the combination.We studied the combination of linezolid plus rifampin in our hollow fiber infection model. We generated a fully parametric drug effect interaction mathematical model. The results were subjected to Monte Carlo simulation to extend the findings to a population of patients by accounting for between-patient variability in drug pharmacokinetics.All monotherapy allowed emergence of resistance over the first two weeks of the experiment. In combination, the interaction was additive for each population (susceptible and resistant. For a 600 mg/600 mg daily regimen of linezolid plus rifampin, we demonstrated that >50% of simulated subjects had eradicated the susceptible population by day 27 with the remaining organisms resistant to one or the other drug. Only 4% of patients had complete organism eradication by experiment end.These data strongly suggest that in order to achieve the goal of shortening therapy, the original regimen may need to be changed at one month to a regimen of two completely new agents with resistance mechanisms independent of the initial regimen. This hypothesis which arose from the analysis is immediately testable in a clinical trial.

  20. Combined DECS Analysis and Next-Generation Sequencing Enable Efficient Detection of Novel Plant RNA Viruses

    Directory of Open Access Journals (Sweden)

    Hironobu Yanagisawa

    2016-03-01

    Full Text Available The presence of high molecular weight double-stranded RNA (dsRNA within plant cells is an indicator of infection with RNA viruses as these possess genomic or replicative dsRNA. DECS (dsRNA isolation, exhaustive amplification, cloning, and sequencing analysis has been shown to be capable of detecting unknown viruses. We postulated that a combination of DECS analysis and next-generation sequencing (NGS would improve detection efficiency and usability of the technique. Here, we describe a model case in which we efficiently detected the presumed genome sequence of Blueberry shoestring virus (BSSV, a member of the genus Sobemovirus, which has not so far been reported. dsRNAs were isolated from BSSV-infected blueberry plants using the dsRNA-binding protein, reverse-transcribed, amplified, and sequenced using NGS. A contig of 4,020 nucleotides (nt that shared similarities with sequences from other Sobemovirus species was obtained as a candidate of the BSSV genomic sequence. Reverse transcription (RT-PCR primer sets based on sequences from this contig enabled the detection of BSSV in all BSSV-infected plants tested but not in healthy controls. A recombinant protein encoded by the putative coat protein gene was bound by the BSSV-antibody, indicating that the candidate sequence was that of BSSV itself. Our results suggest that a combination of DECS analysis and NGS, designated here as “DECS-C,” is a powerful method for detecting novel plant viruses.

  1. Thermodynamic analysis of combined Solid Oxide Electrolyzer and Fischer–Tropsch processes

    International Nuclear Information System (INIS)

    Stempien, Jan Pawel; Ni, Meng; Sun, Qiang; Chan, Siew Hwa

    2015-01-01

    In this paper a thermodynamic analysis and simple optimization of a combined Solid Oxide Electrolyzer Cell and Fisher–Tropsch Synthesis processes for sustainable hydrocarbons fuel production is reported. Comprehensive models are employed to describe effects of temperature, pressure, reactant composition and molar flux and flow on the system efficiency and final production distribution. The electrolyzer model was developed in-house and validated with experimental data of a typical Solid Oxide Electrolyzer. The Fischer–Tropsch Synthesis model employed lumped kinetics of syngas utilization, which includes inhibiting effect of water content and kinetics of Water–Gas Shift reaction. Product distribution model incorporated olefin re-adsorption and varying physisorption and solubility of hydrocarbons with their carbon number. The results were compared with those reported by Becker et al. with simplified analysis of such process. In the present study an opposite effect of operation at elevated pressure was observed. Proposed optimized system achieved overall efficiency of 66.67% and almost equal spread of light- (31%wt), mid-(36%wt) and heavy-hydrocarbons (33%wt). Paraffins contributed the majority of the yield. - Highlights: • Analysis of Solid Oxide Electrolyzer combined with Fisher Tropsch process. • Efficiency of converting water and carbon dioxide into synthetic fuels above 66%. • Effects of process temperature, pressure, gas flux and compositions were analyzed

  2. First research coordination meeting on reference database for neutron activation analysis. Summary report

    International Nuclear Information System (INIS)

    Firestone, R.B.; Trkov, A.

    2005-10-01

    Potential problems associated with nuclear data for neutron activation analysis were identified, the scope of the work to be undertaken was defined together with its priorities, and tasks were assigned to participants. Data testing and measurements refer to gamma spectrum peak evaluations, detector efficiency calibration, neutron spectrum characteristics and reference materials analysis. (author)

  3. Application of Boston matrix combined with SWOT analysis on operational development and evaluations of hospital development.

    Science.gov (United States)

    Tao, Z-Q; Shi, A-M

    2016-05-01

    The aim of this study is to explore the application of Boston matrix combined with SWOT analysis on operational development and evaluations of hospital departments. We selected 73 clinical and medical technology departments of our hospital from 2011 to 2013, and evaluated our hospital by Boston matrix combined with SWOT analysis according to the volume of services, medical quality, work efficiency, patients' evaluations, development capacity, operational capability, economic benefits, comprehensive evaluation of hospital achievement, innovation ability of hospital, influence of hospital, human resources of hospital, health insurance costs, etc. It was found that among clinical departments, there were 11 in Stars (22.4%), 17 in cash cow (34.7%), 15 in question marks (31.2%), 6 Dogs (12.2%), 16 in the youth stage of life cycle assessment (27.6%), 14 in the prime stage (24.1%), 12 in the stationary stage (20.7%), 9 in the aristocracy stage (15.5%) and 7 in the recession stage (12.1%). Among medical technology departments, there were 5 in Stars (20.8%), 1 in Cash cow (4.2%), 10 in question marks (41.6%), 8 Dogs (29.1%), 9 in the youth stage of life cycle assessment (37.5%), 4 in the prime stage (16.7%), 4 in the stable stage (16.7%), 1 in the aristocracy stage (4.2%) and 6 in the recession stage (25%). In conclusion, Boston matrix combined with SWOT analysis is suitable for operational development and comprehensive evaluations of hospital development, and it plays an important role in providing hospitals with development strategies.

  4. Performance analysis of solar parabolic trough collectors driven combined supercritical CO2 and organic Rankine cycle

    Directory of Open Access Journals (Sweden)

    Harwinder Singh

    2018-06-01

    Full Text Available In this paper, attempts have been made on the detailed energy and exergy analysis of solar parabolic trough collectors (SPTCs driven combined power plant. The combination of supercritical CO2 (SCO2 cycle and organic Rankine cycle (ORC integrated with SPTCs has been used to produce power, in which SCO2 cycle and ORC are arranged as a topping and bottoming cycle. Five organic working fluids like R134a, R1234yf, R407c, R1234ze, and R245fa were selected for a low temperature bottoming ORC. Five key exergetic parameters such as exergetic efficiency, exergy destruction rate, fuel depletion ratio, irreversibility ratio, and improvement potential were also examined. It was revealed that exergetic and thermal efficiency of all the combined cycles enhances as the direct normal irradiance increases from 0.5 kW/m2 to 0.95 kW/m2. As can be seen, R407c combined cycle has the maximum exergetic as well as thermal efficiency which is around 78.07% at 0.95 kW/m2 and 43.49% at 0.95 kW/m2, respectively. Alternatively, the R134a and R245fa combined cycle yields less promising results with the marginal difference in their performance. As inferred from the study that SCO2 turbine and evaporator has a certain amount of exergy destruction which is around 9.72% and 8.54% of the inlet exergy, and almost 38.10% of the total exergy destruction in case of R407c combined cycle. Moreover, the maximum amount of exergy destructed by the solar collector field which is more than 25% of the solar inlet exergy and around 54% of the total destructed exergy. Finally, this study concludes that R407c combined cycle has a minimum fuel depletion ratio of 0.2583 for a solar collector and possess the highest power output of 3740 kW. Keywords: Supercritical CO2cycle, Organic Rankine cycle, Exergetic performance, SPTCs, Organic fluids

  5. A phenomenological approach for the analysis of combined fatigue and creep

    International Nuclear Information System (INIS)

    Bui-Quoc, T.; Biron, A.

    1982-01-01

    An approach is proposed for the life prediction, under cumulative damage conditions, for fatigue and for creep. An interaction effect is introduced to account for a modification in the material behavior due to previous loading. A predictive technique is then developed which is applied to several materials for fatigue and which could potentially be used for creep. With due consideration to the similarity of the formulation for both phenomena, the analysis for the combination of fatigue and creep is then carried out through a straightforward sequential use of the two damage functions. Several patterns are studied without and with an interaction effect. (orig.)

  6. Combining Trust and Behavioral Analysis to Detect Security Threats in Open Environments

    Science.gov (United States)

    2010-11-01

    behavioral feature values. This would provide a baseline notional object trust and is formally defined as follows: TO(1)[0, 1] = ∑ 0,n:νbt wtP (S) (8...TO(2)[0, 1] = ∑ wtP (S) · identity(O,P ) (9) 28- 12 RTO-MP-IST-091 Combining Trust and Behavioral Analysis to Detect Security Threats in Open...respectively. The wtP weight function determines the significance of a particular behavioral feature in the final trust calculation. Note that the weight

  7. Combined liquid chromatography-mass spectrometry for trace analysis of pharmaceuticals

    International Nuclear Information System (INIS)

    Schmidt, L.; Danigel, H.; Jungclas, H.

    1982-01-01

    A 252 Cf-plasma desorption mass spectrometer (PDMS) for the analysis of thin layers from nonvolatile organic samples has been set up to be combined with a liquid chromatograph. A novel interface performs the direct inlet of the liquid sample through a capillary into the vacuum system of the spectrometer. Samples of drugs are periodically collected, transferred to the ion source and analysed using a rotating disk. This on-line sample preparation has been tested for three antiarrhythmic drugs using various solvents and mixtures. (orig.)

  8. Simultaneous Analysis of Multiple Elements by Combined Ion-Beam Methods

    International Nuclear Information System (INIS)

    Jiang, Weilin; Weber, William J.; Thevuthasan, Theva; Shutthanandan, Shuttha; J. L. Duggan and I.L. Morgan

    2001-01-01

    Rutherford backscattering spectrometry (RBS) and nuclear reaction analysis (NRA) in channeling geometry have been combined to study the accumulation and recovery of Au2+-induced disorder on both sublattices in 6H-SiC. Conventional He+ RBS/channeling is used to analyze the Ga disorder and Au profiles in Au2+-implanted GaN and the disorder on both the Sr and Ti sublattices in Au2+-implanted SrTiO3. Results on the disorder accumulation in these materials, disorder recovery in 6H-SiC, as well as the mobility of Au implants in GaN are presented and discussed

  9. Thermoeconomic Analysis of Hybrid Power Plant Concepts for Geothermal Combined Heat and Power Generation

    Directory of Open Access Journals (Sweden)

    Florian Heberle

    2014-07-01

    Full Text Available We present a thermo-economic analysis for a low-temperature Organic Rankine Cycle (ORC in a combined heat and power generation (CHP case. For the hybrid power plant, thermal energy input is provided by a geothermal resource coupled with the exhaust gases of a biogas engine. A comparison to alternative geothermal CHP concepts is performed by considering variable parameters like ORC working fluid, supply temperature of the heating network or geothermal water temperature. Second law efficiency as well as economic parameters show that hybrid power plants are more efficient compared to conventional CHP concepts or separate use of the energy sources.

  10. An analysis of the abstracts presented at the annual meetings of the Society for Neuroscience from 2001 to 2006.

    Directory of Open Access Journals (Sweden)

    John M Lin

    2008-04-01

    Full Text Available Annual meeting abstracts published by scientific societies often contain rich arrays of information that can be computationally mined and distilled to elucidate the state and dynamics of the subject field. We extracted and processed abstract data from the Society for Neuroscience (SFN annual meeting abstracts during the period 2001-2006 in order to gain an objective view of contemporary neuroscience. An important first step in the process was the application of data cleaning and disambiguation methods to construct a unified database, since the data were too noisy to be of full utility in the raw form initially available. Using natural language processing, text mining, and other data analysis techniques, we then examined the demographics and structure of the scientific collaboration network, the dynamics of the field over time, major research trends, and the structure of the sources of research funding. Some interesting findings include a high geographical concentration of neuroscience research in the north eastern United States, a surprisingly large transient population (66% of the authors appear in only one out of the six studied years, the central role played by the study of neurodegenerative disorders in the neuroscience community, and an apparent growth of behavioral/systems neuroscience with a corresponding shrinkage of cellular/molecular neuroscience over the six year period. The results from this work will prove useful for scientists, policy makers, and funding agencies seeking to gain a complete and unbiased picture of the community structure and body of knowledge encapsulated by a specific scientific domain.

  11. Thermodynamic analysis of a combined gas turbine, ORC cycle and absorption refrigeration for a CCHP system

    International Nuclear Information System (INIS)

    Mohammadi, Amin; Kasaeian, Alibakhsh; Pourfayaz, Fathollah; Ahmadi, Mohammad Hossein

    2017-01-01

    Highlights: • Thermodynamic analysis of a hybrid CCHP system. • Sensitivity analysis is performed on the most important parameters of the system. • Pressure ratio and gas turbine inlet temperature are the most effective parameters. - Abstract: Hybrid power systems are gained more attention due to their better performance and higher efficiency. Widespread use of these systems improves environmental situation as they reduce the amount of fossil fuel consumption. In this paper a hybrid system composed of a gas turbine, an ORC cycle and an absorption refrigeration cycle is proposed as a combined cooling, heating and power system for residential usage. Thermodynamic analysis is applied on the system. Also a parametric analysis is carried out to investigate the effect of different parameters on the system performance and output cooling, heating and power. The results show that under design conditions, the proposed plant can produce 30 kW power, 8 kW cooling and almost 7.2 ton hot water with an efficiency of 67.6%. Moreover, parametric analysis shows that pressure ratio and gas turbine inlet temperature are the most important and influential parameters. After these two, ORC turbine inlet temperature is the most effective parameter as it can change both net output power and energy efficiency of the system.

  12. Combining Ability in Wheat for Seedling Traits by Line X Tester Analysis Under Saline Conditions

    Directory of Open Access Journals (Sweden)

    Muhammad Osaf

    Full Text Available A line × tester analysis involving five varieties SQ-26, SQ-77, GH-10, 8670, PARC-N2 (lines and three varieties 8721, SARC-5 and DN-4 (testers were crossed to study some hydroponics growing characters. In controlled conditions SQ-26 exhibited the highest positive GCA effects on Shoot length, Shoot fresh weight, Na+ and K+ concentrations, while SQ-77 showed maximum GCA effects on Root length, Root fresh weight and Shoot dry weight in females and in males and both DN-4 and SARC-5 showed the highest GCA effects. Under high saline concentration female SQ-77 showed the maximum positive effects on all characters but on shoot length and Na concentration while male SARC-5 exhibited the highest positive GCA effects on all characters. Under high saline level, the cross combination SQ-26 × 8721 showed SCA effects for shoot length, whereas 8670 x 8721 showed the same effects for shoot fresh weight, root fresh weight and root dry weight. For Na+ and K+ concentrations, the cross combination GH-10 × DN-4 showed then highest SCA effects, whereas for shoot dry weight and root length, the cross combinations GH-10 × SARC-5 and PARC-N2 × 8721 showed the highest SCA effects, respectively.

  13. Analysis of energetic and exergetic efficiency, and environmental benefits of biomass integrated gasification combined cycle technology.

    Science.gov (United States)

    Mínguez, María; Jiménez, Angel; Rodríguez, Javier; González, Celina; López, Ignacio; Nieto, Rafael

    2013-04-01

    The problem of the high carbon dioxide emissions linked to power generation makes necessary active research on the use of biofuels in gas turbine systems as a promising alternative to fossil fuels. Gasification of biomass waste is particularly of interest in obtaining a fuel to be run in gas turbines, as it is an efficient biomass-to-biofuel conversion process, and an integration into a combined cycle power plant leads to a high performance with regard to energetic efficiency. The goal of this study was to carry out an energetic, exergetic and environmental analysis of the behaviour of an integrated gasification combined cycle (IGCC) plant fuelled with different kinds of biomass waste by means of simulations. A preliminary economic study is also included. Although a technological development in gasification technology is necessary, the results of simulations indicate a high technical and environmental interest in the use of biomass integrated gasification combined cycle (BioIGCC) systems for large-scale power generation from biomass waste.

  14. Dynamic Analysis of Wind Power Turbine's Tower under the Combined Action of Winds and Waves

    Institute of Scientific and Technical Information of China (English)

    CHENG You-liang; QU Jiang-man; XUE Zhan-pu; JIANG Yan

    2017-01-01

    To deal with the dynamic response problem of offshore wind power tower under the combined action of winds and waves,finite element method is used to analyze the structure and flow field around the outside flange of the segmentation part.The changes of pressure distribution and vorticity about the outside flange are obtained.Focused on the analysis on the change of hydrostatic pressure and temperature of the tower cut surface,contour lines under the combined action of winds and waves are depicted.Results show that the surface of the offshore wind turbine tower presents instable temperature field when it suffers the action of winds and waves loads,the static pressure increases nonlinearly with the increase of altitude,the fluid vorticity around the outside flange follows an parabolic curve approximately.Results provide a reference for the actual monitoring data of the offshore wind turbine tower under the combined action of winds and waves,so as to ensure the normal operation of tower.

  15. Urban agriculture: a global analysis of the space constraint to meet urban vegetable demand

    International Nuclear Information System (INIS)

    Martellozzo, F; Landry, J-S; Plouffe, D; Seufert, V; Ramankutty, N; Rowhani, P

    2014-01-01

    Urban agriculture (UA) has been drawing a lot of attention recently for several reasons: the majority of the world population has shifted from living in rural to urban areas; the environmental impact of agriculture is a matter of rising concern; and food insecurity, especially the accessibility of food, remains a major challenge. UA has often been proposed as a solution to some of these issues, for example by producing food in places where population density is highest, reducing transportation costs, connecting people directly to food systems and using urban areas efficiently. However, to date no study has examined how much food could actually be produced in urban areas at the global scale. Here we use a simple approach, based on different global-scale datasets, to assess to what extent UA is constrained by the existing amount of urban space. Our results suggest that UA would require roughly one third of the total global urban area to meet the global vegetable consumption of urban dwellers. This estimate does not consider how much urban area may actually be suitable and available for UA, which likely varies substantially around the world and according to the type of UA performed. Further, this global average value masks variations of more than two orders of magnitude among individual countries. The variations in the space required across countries derive mostly from variations in urban population density, and much less from variations in yields or per capita consumption. Overall, the space required is regrettably the highest where UA is most needed, i.e., in more food insecure countries. We also show that smaller urban clusters (i.e., <100 km 2 each) together represent about two thirds of the global urban extent; thus UA discourse and policies should not focus on large cities exclusively, but should also target smaller urban areas that offer the greatest potential in terms of physical space. (letters)

  16. Visualization of Global Sensitivity Analysis Results Based on a Combination of Linearly Dependent and Independent Directions

    Science.gov (United States)

    Davies, Misty D.; Gundy-Burlet, Karen

    2010-01-01

    A useful technique for the validation and verification of complex flight systems is Monte Carlo Filtering -- a global sensitivity analysis that tries to find the inputs and ranges that are most likely to lead to a subset of the outputs. A thorough exploration of the parameter space for complex integrated systems may require thousands of experiments and hundreds of controlled and measured variables. Tools for analyzing this space often have limitations caused by the numerical problems associated with high dimensionality and caused by the assumption of independence of all of the dimensions. To combat both of these limitations, we propose a technique that uses a combination of the original variables with the derived variables obtained during a principal component analysis.

  17. A combined experimental and FE analysis procedure to evaluate tensile behavior of zircaloy pressure tubes

    International Nuclear Information System (INIS)

    Samal, M.K.; Vaze, K.K.; Balakrishnan, K.S.; Anantharaman, S.

    2012-01-01

    Determination of transverse mechanical properties from the ring type of specimens directly machined from the nuclear reactor pressure tubes is not straightforward because of the presence of combined membrane as well as bending stresses arising in the loaded condition. In this work, we have performed ring-tensile tests on the un-irradiated ring tensile specimen using two split semi-cylindrical mandrels as the loading device. A 3-D finite element (FE) analysis was performed in order to determine the material true stress-strain curve by comparing experimental load-displacement data with those predicted by FE analysis. In order to validate the methodology, miniaturized tensile specimens were machined from these tubes and tested. It was observed that the stress-strain data as obtained from ring tensile specimen could describe the load displacement curve of the miniaturized flat tensile specimen very well. (author)

  18. Combining Generated Data Models with Formal Invalidation for Insider Threat Analysis

    DEFF Research Database (Denmark)

    Kammuller, Florian; Probst, Christian W.

    2014-01-01

    draw from recent insights into generation of insider data to complement a logic based mechanical approach. We show how insider analysis can be traced back to the early days of security verification and the Lowe-attack on NSPK. The invalidation of policies allows modelchecking organizational structures......In this paper we revisit the advances made on invalidation policies to explore attack possibilities in organizational models. One aspect that has so far eloped systematic analysis of insider threat is the integration of data into attack scenarios and its exploitation for analyzing the models. We...... to detect insider attacks. Integration of higher order logic specification techniques allows the use of data refinement to explore attack possibilities beyond the initial system specification. We illustrate this combined invalidation technique on the classical example of the naughty lottery fairy. Data...

  19. Development of a combined portable x-ray fluorescence and Raman spectrometer for in situ analysis.

    Science.gov (United States)

    Guerra, M; Longelin, S; Pessanha, S; Manso, M; Carvalho, M L

    2014-06-01

    In this work, we have built a portable X-ray fluorescence (XRF) spectrometer in a planar configuration coupled to a Raman head and a digital optical microscope, for in situ analysis. Several geometries for the XRF apparatus and digital microscope are possible in order to overcome spatial constraints and provide better measurement conditions. With this combined spectrometer, we are now able to perform XRF and Raman measurements in the same point without the need for sample collection, which can be crucial when dealing with cultural heritage objects, as well as forensic analysis. We show the capabilities of the spectrometer by measuring several standard reference materials, as well as other samples usually encountered in cultural heritage, geological, as well as biomedical studies.

  20. Analysis of general and specific combining abilities of popcorn populations, including selfed parents

    Directory of Open Access Journals (Sweden)

    José Marcelo Soriano Viana

    2003-12-01

    Full Text Available Estimation of general and specific combining ability effects in a diallel analysis of cross-pollinating populations, including the selfed parents, is presented in this work. The restrictions considered satisfy the parametric values of the GCA and SCA effects. The method is extended to self-pollinating populations (suitable for other species, without the selfed parents. The analysis of changes in population means due to inbreeding (sensitivity to inbreeding also permits to assess the predominant direction of dominance deviations and the relative genetic variability in each parent population. The methodology was used to select popcorn populations for intra- and inter-population breeding programs and for hybrid production, developed at the Federal University of Viçosa, MG, Brazil. Two yellow pearl grain popcorn populations were selected.

  1. Evaluation of performance of footwear and flooring systems in combination with personnel using voltage probability analysis

    International Nuclear Information System (INIS)

    Smallwood, Jeremy; Swenson, David E

    2011-01-01

    Evaluation of electrostatic performance of footwear and flooring in combination is necessary in applications such as electrostatic discharge (ESD) control in electronics manufacture, evaluation of equipment for avoidance of factory process electrostatic ignition risks and avoidance of electrostatic shocks to personnel in working environments. Typical standards use a walking test in which the voltage produced on a subject is evaluated by identification and measurement of the magnitude of the 5 highest 'peaks' and 'valleys' of the recorded voltage waveform. This method does not lend itself to effective analysis of the risk that the voltage will exceed a hazard threshold. This paper shows the advantages of voltage probability analysis and recommends that the method is adopted for use in future standards.

  2. Evaluation of performance of footwear and flooring systems in combination with personnel using voltage probability analysis

    Science.gov (United States)

    Smallwood, Jeremy; Swenson, David E.

    2011-06-01

    Evaluation of electrostatic performance of footwear and flooring in combination is necessary in applications such as electrostatic discharge (ESD) control in electronics manufacture, evaluation of equipment for avoidance of factory process electrostatic ignition risks and avoidance of electrostatic shocks to personnel in working environments. Typical standards use a walking test in which the voltage produced on a subject is evaluated by identification and measurement of the magnitude of the 5 highest "peaks" and "valleys" of the recorded voltage waveform. This method does not lend itself to effective analysis of the risk that the voltage will exceed a hazard threshold. This paper shows the advantages of voltage probability analysis and recommends that the method is adopted for use in future standards.

  3. Evaluation of performance of footwear and flooring systems in combination with personnel using voltage probability analysis

    Energy Technology Data Exchange (ETDEWEB)

    Smallwood, Jeremy [Electrostatic Solutions Ltd (United Kingdom); Swenson, David E, E-mail: jeremys@static-sol.com [Affinity Static Control Consulting LLC (United States)

    2011-06-23

    Evaluation of electrostatic performance of footwear and flooring in combination is necessary in applications such as electrostatic discharge (ESD) control in electronics manufacture, evaluation of equipment for avoidance of factory process electrostatic ignition risks and avoidance of electrostatic shocks to personnel in working environments. Typical standards use a walking test in which the voltage produced on a subject is evaluated by identification and measurement of the magnitude of the 5 highest 'peaks' and 'valleys' of the recorded voltage waveform. This method does not lend itself to effective analysis of the risk that the voltage will exceed a hazard threshold. This paper shows the advantages of voltage probability analysis and recommends that the method is adopted for use in future standards.

  4. Analysis of polymeric phenolics in red wines using different techniques combined with gel permeation chromatography fractionation.

    Science.gov (United States)

    Guadalupe, Zenaida; Soldevilla, Alberto; Sáenz-Navajas, María-Pilar; Ayestarán, Belén

    2006-04-21

    A multiple-step analytical method was developed to improve the analysis of polymeric phenolics in red wines. With a common initial step based on the fractionation of wine phenolics by gel permeation chromatography (GPC), different analytical techniques were used: high-performance liquid chromatography-diode array detection (HPLC-DAD), HPLC-mass spectrometry (MS), capillary zone electrophoresis (CZE) and spectrophotometry. This method proved to be valid for analyzing different families of phenolic compounds, such as monomeric phenolics and their derivatives, polymeric pigments and proanthocyanidins. The analytical characteristics of fractionation by GPC were studied and the method was fully validated, yielding satisfactory statistical results. GPC fractionation substantially improved the analysis of polymeric pigments by CZE, in terms of response, repeatability and reproducibility. It also represented an improvement in the traditional vanillin assay used for proanthocyanidin (PA) quantification. Astringent proanthocyanidins were also analyzed using a simple combined method that allowed these compounds, for which only general indexes were available, to be quantified.

  5. Mechanical system reliability analysis using a combination of graph theory and Boolean function

    International Nuclear Information System (INIS)

    Tang, J.

    2001-01-01

    A new method based on graph theory and Boolean function for assessing reliability of mechanical systems is proposed. The procedure for this approach consists of two parts. By using the graph theory, the formula for the reliability of a mechanical system that considers the interrelations of subsystems or components is generated. Use of the Boolean function to examine the failure interactions of two particular elements of the system, followed with demonstrations of how to incorporate such failure dependencies into the analysis of larger systems, a constructive algorithm for quantifying the genuine interconnections between the subsystems or components is provided. The combination of graph theory and Boolean function provides an effective way to evaluate the reliability of a large, complex mechanical system. A numerical example demonstrates that this method an effective approaches in system reliability analysis

  6. Combining optimisation and simulation in an energy systems analysis of a Swedish iron foundry

    International Nuclear Information System (INIS)

    Mardan, Nawzad; Klahr, Roger

    2012-01-01

    To face global competition, and also reduce environmental and climate impact, industry-wide changes are needed, especially regarding energy use, which is closely related to global warming. Energy efficiency is therefore an essential task for the future as it has a significant impact on both business profits and the environment. For the analysis of possible changes in industrial production processes, and to choose what changes should be made, various modelling tools can be used as a decision support. This paper uses two types of energy analysis tool: Discrete Event Simulation (DES) and Energy Systems Optimisation (ESO). The aim of this study is to describe how a DES and an ESO tool can be combined. A comprehensive five-step approach is proposed for reducing system costs and making a more robust production system. A case study representing a new investment in part of a Swedish iron foundry is also included to illustrate the method's use. The method described in this paper is based on the use of the DES program QUEST and the ESO tool reMIND. The method combination itself is generic, i.e. other similar programs can be used as well with some adjustments and adaptations. The results from the case study show that when different boundary conditions are used the result obtained from the simulation tools is not optimum, in other words, the result shows only a feasible solution and not the best way to run the factory. It is therefore important to use the optimisation tool in such cases in order to obtain the optimum operating strategy. By using the optimisation tool a substantial amount of resources can be saved. The results also show that the combination of optimisation and simulation tools is useful to provide very detailed information about how the system works and to predict system behaviour as well as to minimise the system cost. -- Highlights: ► This study describes how a simulation and an optimisation tool can be combined. ► A case study representing a new

  7. Overall performance assessment of a combined cycle power plant: An exergo-economic analysis

    International Nuclear Information System (INIS)

    Sahin, Ahmet Z.; Al-Sharafi, Abdullah; Yilbas, Bekir S.; Khaliq, Abdul

    2016-01-01

    Highlights: • An exergo-economic analysis is carried out for a combined cycle power plant. • An overall performance index (OPI) is defined to analyze the power plant. • Four performance indicators and three scenarios are considered in the analysis. • The optimum configuration of the power plant differs for each scenarios considered. - Abstract: An exergo-economic analysis is carried out for a combined cycle power plant using the first law and the second law of thermodynamics, and the economic principles while incorporating GT PRO/PEACE Software Packages. An overall performance index (OPI) is defined to assess and analyze the optimum operational and design configurations of the power plant. Four performance indicators are considered for the analysis; namely, energy efficiency (ENE), exergy efficiency (EXE), levelized cost of electricity (COE), and the total investment (TI) cost. Three possible scenarios are considered in which different weight factor is assigned to the performance indicators when assessing the performance. These scenarios are: (i) the conventional case in which the levelized cost of electricity is given a high priority, (ii) environmental conscious case in which the exergy efficiency is given a high priority, and (iii) the economical case in which the total cost of investment is given a high priority. It is shown that the optimum size and the configuration of the power plant differ for each scenarios considered. The selection and optimization of the size and configuration of the power plant are found to be depending on the user priorities and the weight factors assigned to the performance indicators.

  8. Optimal combinations of control strategies and cost-effective analysis for visceral leishmaniasis disease transmission.

    Directory of Open Access Journals (Sweden)

    Santanu Biswas

    Full Text Available Visceral leishmaniasis (VL is a deadly neglected tropical disease that poses a serious problem in various countries all over the world. Implementation of various intervention strategies fail in controlling the spread of this disease due to issues of parasite drug resistance and resistance of sandfly vectors to insecticide sprays. Due to this, policy makers need to develop novel strategies or resort to a combination of multiple intervention strategies to control the spread of the disease. To address this issue, we propose an extensive SIR-type model for anthroponotic visceral leishmaniasis transmission with seasonal fluctuations modeled in the form of periodic sandfly biting rate. Fitting the model for real data reported in South Sudan, we estimate the model parameters and compare the model predictions with known VL cases. Using optimal control theory, we study the effects of popular control strategies namely, drug-based treatment of symptomatic and PKDL-infected individuals, insecticide treated bednets and spray of insecticides on the dynamics of infected human and vector populations. We propose that the strategies remain ineffective in curbing the disease individually, as opposed to the use of optimal combinations of the mentioned strategies. Testing the model for different optimal combinations while considering periodic seasonal fluctuations, we find that the optimal combination of treatment of individuals and insecticide sprays perform well in controlling the disease for the time period of intervention introduced. Performing a cost-effective analysis we identify that the same strategy also proves to be efficacious and cost-effective. Finally, we suggest that our model would be helpful for policy makers to predict the best intervention strategies for specific time periods and their appropriate implementation for elimination of visceral leishmaniasis.

  9. Combining ability analysis for yield and related traits in basmati rice (oryza sativa L.)

    International Nuclear Information System (INIS)

    Saleem, M.Y.; Haq, M.A.; Mirza, J.I.

    2010-01-01

    Line X tester experiment was conducted to evaluate the performance of 27 F1 hybrids along with 12 parents in Basmati rice. Analysis of variance revealed highly significant differences among treatments, parents, parents vs. crosses and crosses for number of tillers per plant, panicle length, number of grains per panicle, fertility percentage, 1000-grain weight and yield per plant. Lines were significant for number of tillers per plant, number of grains per panicle and 1000-grain weight while testers and lines X testers were significant for all the traits. The estimates of variance of specific combining ability effects, ratio of variance of general combining ability to specific combining ability and degree of dominance indicated preponderance of non-additive gene effects for each trait. On over all basis, role of testers in the expression of most of the yield components was more than lines and line X tester interaction. However, line X tester interaction contributed more than lines and testers for yield per plant. Three lines viz., Basmati 2000, Super Basmati and Kashmir Basmati and one tester Basmati-385 were identified as good general combiners based on their mean performance and GCA effects for yield and its various traits. Hybrids like Basmati Pak X Basmati-385, Super Basmati X Basmati-385, DM-107-4 X Basmati-385, Basmati 2000 X EL-30- 2-1, Basmati 2000 X DM-25, DM-16-5-1 X Basmati-385 and Kashmir Basmati X DM-25 showed high mean performance, SCA effects and heterobeltiosis for grain yield and are proposed for heterosis breeding. (author)

  10. Clinical analysis of intravitreal injection of Conbercept combined with 532-laser treating Coats disease in adulthood

    Directory of Open Access Journals (Sweden)

    Li Jiang

    2017-07-01

    Full Text Available AIM: To analyze clinical observation and the efficiency of intravitreal conbercept combined with 532-laser on Coats disease in adulthood. METHODS: This was an retrospective analysis. Six eyes from 6 patients(5 males and 1 femalewith coats disease diagnosed by fundus fluorescein angiography(FFAand optical coherence tomography(OCTwere enrolled. Before the injection, best-corrected visual acuity(BCVAof early treatment of diabetic retinopathy study(ETDRS, non-contact tonometer, ophthalmoscope, fundus photography, FFA, and OCT were examined. The initial average visual acuity(ETDRS letterswere 51.17±15.15. The initial average central retina thickness(CRTwas 303.30±107.87μm. All affected eyes were treated with intravitreal conbercept 0.05mL(10mg/mLcombined with 532-laser. Patients were followed up for 6 to 12mo, with a mean duration of 7.33±1.26mo. Post-treatment BCVA were compared with baseline using repeat analysis. RESULTS: The mean BCVA showed significant improvement during 1 wk, 1, 3mo post-treatment and the latest follow up(PCONCLUSION: Coats disease in adulthood more likely to have lower symptom and have a better response on treatment. Intravitreal conbercept combined with 532-laser significantly improve visual acuity and absorb the subretina fluid.

  11. COMBINED ANALYSIS OF IMAGES AND SPECTRAL ENERGY DISTRIBUTIONS OF TAURUS PROTOSTARS

    International Nuclear Information System (INIS)

    Gramajo, Luciana V.; Gomez, Mercedes; Whitney, Barbara A.; Robitaille, Thomas P.

    2010-01-01

    We present an analysis of spectral energy distributions (SEDs), near- and mid-infrared images, and Spitzer spectra of eight embedded Class I/II objects in the Taurus-Auriga molecular cloud. The initial model for each source was chosen using the grid of young stellar objects (YSOs) and SED fitting tool of Robitaille et al. Then the models were refined using the radiative transfer code of Whitney et al. to fit both the spectra and the infrared images of these objects. In general, our models agree with previous published analyses. However, our combined models should provide more reliable determinations of the physical and geometrical parameters since they are derived from SEDs, including the Spitzer spectra, covering the complete spectral range; and high-resolution near-infrared and Spitzer IRAC images. The combination of SED and image modeling better constrains the different components (central source, disk, envelope) of the YSOs. Our derived luminosities are higher, on average, than previous estimates because we account for the viewing angles (usually nearly edge-on) of most of the sources. Our analysis suggests that the standard rotating collapsing protostar model with disks and bipolar cavities works well for the analyzed sample of objects in the Taurus molecular cloud.

  12. Combined use of correlation dimension and entropy as discriminating measures for time series analysis

    Science.gov (United States)

    Harikrishnan, K. P.; Misra, R.; Ambika, G.

    2009-09-01

    We show that the combined use of correlation dimension (D2) and correlation entropy (K2) as discriminating measures can extract a more accurate information regarding the different types of noise present in a time series data. For this, we make use of an algorithmic approach for computing D2 and K2 proposed by us recently [Harikrishnan KP, Misra R, Ambika G, Kembhavi AK. Physica D 2006;215:137; Harikrishnan KP, Ambika G, Misra R. Mod Phys Lett B 2007;21:129; Harikrishnan KP, Misra R, Ambika G. Pramana - J Phys, in press], which is a modification of the standard Grassberger-Proccacia scheme. While the presence of white noise can be easily identified by computing D2 of data and surrogates, K2 is a better discriminating measure to detect colored noise in the data. Analysis of time series from a real world system involving both white and colored noise is presented as evidence. To our knowledge, this is the first time that such a combined analysis is undertaken on a real world data.

  13. A combined morphometric analysis of foot form and its association with sex, stature, and body mass.

    Science.gov (United States)

    Domjanic, Jacqueline; Seidler, Horst; Mitteroecker, Philipp

    2015-08-01

    Morphometric analysis of footprints is a classic means for orthopedic diagnosis. In forensics and physical anthropology, it is commonly used for the estimation of stature and body mass. We studied individual variation and sexual dimorphism of foot dimensions and footprint shape by a combination of classic foot measurements and geometric morphometric methods. Left and right feet of 134 healthy adult males and females were scanned twice with a 3D optical laser scanner, and stature as well as body mass were recorded. Foot length and width were measured on the 3D scans. The 2D footprints were extracted as the plantar-most 2 mm of the 3D scans and measured with 85 landmarks and semilandmarks. Both foot size and footprint shape are sexually dimorphic and relate to stature and body mass. While dimorphism in foot length largely results from dimorphism in stature, dimorphism in footprint shape partly owes to the dimorphism in BMI. Stature could be estimated well based on foot length (R(2)  = 0.76), whereas body mass was more closely related to foot width (R(2)  = 0.62). Sex could be estimated correctly for 95% of the individuals based on a combination of foot width and length. Geometric morphometrics proved to be an effective tool for the detailed analysis of footprint shape. However, for the estimation of stature, body mass, and sex, shape variables did not considerably improve estimates based on foot length and width. © 2015 Wiley Periodicals, Inc.

  14. A combined method for analysis of the acoustic emission signals from aboveground storage tank bottom

    Energy Technology Data Exchange (ETDEWEB)

    Yewei Kang; Mingchun Ling; Min Xiong; Yi Sun; Dongjie Tan [PetroChina Pipeline R and D Center, Langfang (China)

    2009-07-01

    In the late 1980s acoustic emission (AE) technology was first used to assess the corrosion of aboveground storage tank (AST) bottoms. From then on, it attracts great attention because it can do in-service inspection. Recognizing and eliminating noise is still the main challenge due to the small size of the signals in the presence of potential process noise when the AE signals are processed. In this paper a method combining pattern recognition with traditional AE parametric analysis is introduced to assess the corrosion of AST bottom. First, the AE signals are clustered in different clusters by a clustering method based on the distances of AE signal features. The reasonable cluster is selected for next analysis step. Second, a statistical method is used to evaluate the activities of AE on which the final evaluation report is based. Practical inspection is done on a large oil storage tank in the Chongqing distribution station of Lanzhou- Chengdu-Chongqing product oil pipeline of PetroChina Pipeline Company. The analytical result indicates that the combined method is reliable and feasible. (author)

  15. A Thermodynamic Analysis of Two Competing Mid-Sized Oxyfuel Combustion Combined Cycles

    Directory of Open Access Journals (Sweden)

    Egill Thorbergsson

    2016-01-01

    Full Text Available A comparative analysis of two mid-sized oxyfuel combustion combined cycles is performed. The two cycles are the semiclosed oxyfuel combustion combined cycle (SCOC-CC and the Graz cycle. In addition, a reference cycle was established as the basis for the analysis of the oxyfuel combustion cycles. A parametric study was conducted where the pressure ratio and the turbine entry temperature were varied. The layout and the design of the SCOC-CC are considerably simpler than the Graz cycle while it achieves the same net efficiency as the Graz cycle. The fact that the efficiencies for the two cycles are close to identical differs from previously reported work. Earlier studies have reported around a 3% points advantage in efficiency for the Graz cycle, which is attributed to the use of a second bottoming cycle. This additional feature is omitted to make the two cycles more comparable in terms of complexity. The Graz cycle has substantially lower pressure ratio at the optimum efficiency and has much higher power density for the gas turbine than both the reference cycle and the SCOC-CC.

  16. Detection of Yersinia enterocolitica in milk powders by cross-priming amplification combined with immunoblotting analysis.

    Science.gov (United States)

    Zhang, Hongwei; Feng, Shaolong; Zhao, Yulong; Wang, Shuo; Lu, Xiaonan

    2015-12-02

    Yersinia enterocolitica (Y. enterocolitica) is frequently isolated from a wide variety of foods and can cause human yersiniosis. Biochemical and culture-based assays are common detection methods, but require a long incubation time and easily misidentify Y. enterocolitica as other non-pathogenic Yersinia species. Alternatively, cross-priming amplification (CPA) under isothermal conditions combined with immunoblotting analysis enables a more sensitive detection in a relatively short time period. A set of specific displacement primers, cross primers and testing primers was designed on the basis of six specific sequences in Y. enterocolitica 16S-23S rDNA internal transcribed spacer. Under isothermal condition, amplification and hybridization were conducted simultaneously at 63°C for 60 min. The specificity of CPA was tested for 96 different bacterial strains and 165 commercial milk powder samples. Two red lines were developed on BioHelix Express strip for all of the Y. enterocolitica strains, and one red line was shown for non-Y. enterocolitica strains. The limit of detection of CPA was 10(0)fg for genomic DNA (1000 times more sensitive than PCR assay), 10(1) CFU/ml for pure bacterial culture, and 10(0) CFU per 100 g milk powder with pre-enrichment at 37°C for 24 h. CPA combined with immunoblotting analysis can achieve highly specific and sensitive detection of Y. enterocolitica in milk powder in 90 min after pre-enrichment. Copyright © 2015 Elsevier B.V. All rights reserved.

  17. Thermodynamic performance analysis and optimization of a solar-assisted combined cooling, heating and power system

    International Nuclear Information System (INIS)

    Wang, Jiangjiang; Lu, Yanchao; Yang, Ying; Mao, Tianzhi

    2016-01-01

    This study aims to present a thermodynamic performance analysis and to optimize the configurations of a hybrid combined cooling, heating and power (CCHP) system incorporating solar energy and natural gas. A basic natural gas CCHP system containing a power generation unit, a heat recovery system, an absorption cooling system and a storage tank is integrated with solar photovoltaic (PV) panels and/or a heat collector. Based on thermodynamic modeling, the thermodynamic performance, including energy and exergy efficiencies, under variable work conditions, such as electric load factor, solar irradiance and installation ratio, of the solar PV panels and heat collector is investigated and analyzed. The results of the energy supply side analysis indicate that the integration of solar PV into the CCHP system more efficiently improves the exergy efficiency, whereas the integration of a solar heat collector improves the energy efficiency. To match the building loads, the optimization method combined with the operation strategy is employed to optimize the system configurations to maximize the integrated benefits of energy and economic costs. The optimization results of demand–supply matching demonstrate that the integration of a solar heat collector achieves a better integrated performance than the solar PV integration in the specific case study. - Highlights: • Design a CCHP system integrated with solar PV and heat collector. • Present the energy and exergy analyses under variable work conditions. • Propose an optimization method of CCHP system for demand-supply matching.

  18. Summary report of second research coordination meeting on development of a reference database for ion beam analysis

    International Nuclear Information System (INIS)

    Vickridge, Ian; Schwerer, Otto

    2007-07-01

    Highlights of the 2nd Research Coordination Meeting (RCM) are given with respect to the progress achieved in the first 1 1/2 years of the Co-ordinated Research Project (CRP) on Development of a Reference Database for Ion Beam Analysis. Participants presented the results of their work to date, and identified and assigned key tasks required to ensure that the final output of the CRP is achieved. In addition, a number of lively and productive discussions took place concerning technical issues such as accelerator energy calibration, error reporting, accuracy of the existing IBANDL and EXFOR datasets for IBA, and procedures for producing recommended cross-section data. The main conclusions as well as lists of actions and tasks are presented in this report. (author)

  19. ``Turbo-KWK `99``. Combined-cycle power stations with gas turbines. Technical meeting; Turbo-KWK `99. Kraft-Waerme-Kopplung mit Gasturbinen. Fachtagung

    Energy Technology Data Exchange (ETDEWEB)

    1999-09-01

    This conference report comprises 18 contributions on the technological success of gas turbines in power generation, e.g.: Maximum power generation efficiency of combined cycle systems, flexibility of power generation, reduction of air pollution, hot gas production for drying processes and environment-friendly cold generation in the pharmaceutical and printing industries. The final contribution presents an outlook to the future.

  20. ANALYSIS OF COMBINED UAV-BASED RGB AND THERMAL REMOTE SENSING DATA: A NEW APPROACH TO CROWD MONITORING

    Directory of Open Access Journals (Sweden)

    S. Schulte

    2017-08-01

    Full Text Available Collecting vast amount of data does not solely help to fulfil information needs related to crowd monitoring, it is rather important to collect data that is suitable to meet specific information requirements. In order to address this issue, a prototype is developed to facilitate the combination of UAV-based RGB and thermal remote sensing datasets. In an experimental approach, image sensors were mounted on a remotely piloted aircraft and captured two video datasets over a crowd. A group of volunteers performed diverse movements that depict real world scenarios. The prototype is deriving the movement on the ground and is programmed in MATLAB. This novel detection approach using combined data is afterwards evaluated against detection algorithms that only use a single data source. Our tests show that the combination of RGB and thermal remote sensing data is beneficial for the field of crowd monitoring regarding the detection of crowd movement.

  1. Integrated gasification gas combined cycle plant with membrane reactors: Technological and economical analysis

    International Nuclear Information System (INIS)

    Amelio, Mario; Morrone, Pietropaolo; Gallucci, Fausto; Basile, Angelo

    2007-01-01

    In the present work, the capture and storage of carbon dioxide from the fossil fuel power plant have been considered. The main objective was to analyze the thermodynamic performances and the technological aspects of two integrated gasification gas combined cycle plants (IGCC), as well as to give a forecast of the investment costs for the plants and the resulting energy consumptions. The first plant considered is an IGCC* plant (integrated gasification gas combined cycle plant with traditional shift reactors) characterized by the traditional water gas shift reactors and a CO 2 physical adsorption system followed by the power section. The second one is an IGCC M plant (integrated gasification gas combined cycle plant with membrane reactor) where the coal thermal input is the same as the first one, but the traditional shift reactors and the physical adsorption unit are replaced by catalytic palladium membrane reactors (CMR). In the present work, a mono-dimensional computational model of the membrane reactor was proposed to simulate and evaluate the capability of the IGCC M plant to capture carbon dioxide. The energetic performances, efficiency and net power of the IGCC* and IGCC M plants were, thus, compared, assuming as standard a traditional IGCC plant without carbon dioxide capture. The economical aspects of the three plants were compared through an economical analysis. Since the IGCC* and IGCC M plants have additional costs related to the capture and disposal of the carbon dioxide, a Carbon Tax (adopted in some countries like Sweden) proportional to the number of kilograms of carbon dioxide released in the environment was assumed. According to the economical analysis, the IGCC M plant proved to be more convenient than the IGCC* one

  2. Authentication of Whey Protein Powders by Portable Mid-Infrared Spectrometers Combined with Pattern Recognition Analysis.

    Science.gov (United States)

    Wang, Ting; Tan, Siow Ying; Mutilangi, William; Aykas, Didem P; Rodriguez-Saona, Luis E

    2015-10-01

    The objective of this study was to develop a simple and rapid method to differentiate whey protein types (WPC, WPI, and WPH) used for beverage manufacturing by combining the spectral signature collected from portable mid-infrared spectrometers and pattern recognition analysis. Whey protein powders from different suppliers are produced using a large number of processing and compositional variables, resulting in variation in composition, concentration, protein structure, and thus functionality. Whey protein powders including whey protein isolates, whey protein concentrates and whey protein hydrolysates were obtained from different suppliers and their spectra collected using portable mid-infrared spectrometers (single and triple reflection) by pressing the powder onto an Attenuated Total Reflectance (ATR) diamond crystal with a pressure clamp. Spectra were analyzed by soft independent modeling of class analogy (SIMCA) generating a classification model showing the ability to differentiate whey protein types by forming tight clusters with interclass distance values of >3, considered to be significantly different from each other. The major bands centered at 1640 and 1580 cm(-1) were responsible for separation and were associated with differences in amide I and amide II vibrations of proteins, respectively. Another important band in whey protein clustering was associated with carboxylate vibrations of acidic amino acids (∼1570 cm(-1)). The use of a portable mid-IR spectrometer combined with pattern recognition analysis showed potential for discriminating whey protein ingredients that can help to streamline the analytical procedure so that it is more applicable for field-based screening of ingredients. A rapid, simple and accurate method was developed to authenticate commercial whey protein products by using portable mid-infrared spectrometers combined with chemometrics, which could help ensure the functionality of whey protein ingredients in food applications. © 2015

  3. Discriminative Nonlinear Analysis Operator Learning: When Cosparse Model Meets Image Classification.

    Science.gov (United States)

    Wen, Zaidao; Hou, Biao; Jiao, Licheng

    2017-05-03

    Linear synthesis model based dictionary learning framework has achieved remarkable performances in image classification in the last decade. Behaved as a generative feature model, it however suffers from some intrinsic deficiencies. In this paper, we propose a novel parametric nonlinear analysis cosparse model (NACM) with which a unique feature vector will be much more efficiently extracted. Additionally, we derive a deep insight to demonstrate that NACM is capable of simultaneously learning the task adapted feature transformation and regularization to encode our preferences, domain prior knowledge and task oriented supervised information into the features. The proposed NACM is devoted to the classification task as a discriminative feature model and yield a novel discriminative nonlinear analysis operator learning framework (DNAOL). The theoretical analysis and experimental performances clearly demonstrate that DNAOL will not only achieve the better or at least competitive classification accuracies than the state-of-the-art algorithms but it can also dramatically reduce the time complexities in both training and testing phases.

  4. Proceedings of the first analysis meeting on JUPITER-II Program

    Energy Technology Data Exchange (ETDEWEB)

    Shiradata, Keisho; Yamamoto, Masaaki [comps.

    1984-12-31

    The JUPITER-II Program is the Joint Physics Large Heterogeneous Core Critical Experiments Program between the U.S. Department of Energy (US DOE) and PNC, Japan. The experiments began in May 1982 and ended in April 1984, as a part of the ZPPR-13 program. The ZPPR-13 is a series of critical assemblies designed to study the fundamental neutronic behavior of large, radially-heterogeneous LMFBR cores. This report describes the results of analysis of ZPPR-13A and preliminary analysis of ZPPR-13B, and some topics of recent activities in fast reactor physics.

  5. Proceedings of the first analysis meeting on JUPITER-II Program

    Energy Technology Data Exchange (ETDEWEB)

    Shiradata, Keisho; Yamamoto, Masaaki [comps.

    1985-12-31

    The JUPITER-II Program is the Joint Physics Large Heterogeneous Core Critical Experiments Program between the U.S. Department of Energy (US DOE) and PNC, Japan. The experiments began in May 1982 and ended in April 1984, as a part of the ZPPR-13 program. The ZPPR-13 is a series of critical assemblies designed to study the fundamental neutronic behavior of large, radially-heterogeneous LMFBR cores. This report describes the results of analysis of ZPPR-13A and preliminary analysis of ZPPR-13B, and some topics of recent activities in fast reactor physics.

  6. Proceedings of the first analysis meeting on JUPITER Program. Report SN-241-80-14

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1980-09-01

    These proceedings provide an analysis of the JUPITER Experiment in ZPPR-9. A general description of data and methods is provided along with discussions of criticality, reaction rate ratio and reaction rate, Doppler and sample reactivity worth, sodium void worth, and control rod worth. Topics provided are: Considerations on a Critical Experiment Program for a Large Fast Breeder Reactor; Analysis of Sodium Void Worths in ZPPR-3 Modified Phase 3 Core; Fuel Pin and Subassembly Heterogeneity Effect on Neutronics Properties of a Fast Power Reactor; and An Evaluation Method for Mesh Size Effects in Neutron Diffusion Calculations. The individual topics have been cataloged separately.

  7. Meeting the reactor operator's information needs using functional analysis

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, W.R.; Clark, M.T.

    1980-01-01

    Since the accident at Three Mile Island, many ideas have been proposed for assisting the reactor operator during emergency situations. However, some of the suggested remedies do not alleviate an important shortcoming of the TMI control room: the operators were not presented with the information they needed in a manner which would allow prompt diagnosis of the problem. To address this problem, functional analysis is being applied at the LOFT facility to ensure that the operator's information needs are being met in his procedures and graphic displays. This paper summarizes the current applications of functional analysis at LOFT.

  8. 3D analysis of semiconductor devices: A combination of 3D imaging and 3D elemental analysis

    Science.gov (United States)

    Fu, Bianzhu; Gribelyuk, Michael A.

    2018-04-01

    3D analysis of semiconductor devices using a combination of scanning transmission electron microscopy (STEM) Z-contrast tomography and energy dispersive spectroscopy (EDS) elemental tomography is presented. 3D STEM Z-contrast tomography is useful in revealing the depth information of the sample. However, it suffers from contrast problems between materials with similar atomic numbers. Examples of EDS elemental tomography are presented using an automated EDS tomography system with batch data processing, which greatly reduces the data collection and processing time. 3D EDS elemental tomography reveals more in-depth information about the defect origin in semiconductor failure analysis. The influence of detector shadowing and X-rays absorption on the EDS tomography's result is also discussed.

  9. LANCE Usage and User Analysis: Creating a Better System that Meets User Needs

    Science.gov (United States)

    Davies, D.; Boller, R. A.; Schmaltz, J. E.; Murphy, K. J.; Ilavajhala, S.; Ullah, A.; Joshi, T.

    2012-12-01

    This paper describes known uses of NASA's Land Atmosphere Near-real time Capability for EOS (LANCE) data and imagery and summarizes findings from informal interviews with LANCE users, undertaken to better understand their needs. LANCE, the NRT component of EOSDIS, provides products from MODIS, AIRS, OMI and MLS within 3 hours of satellite observation. LANCE has in excess of 50,000 unique anonymous users per month using data and imagery for wildfire management, air quality measurements, shipping, agricultural forecasting as well as monitoring volcanic plumes, dust storms, smoke plumes and floods etc. Users can be categorized as end users or as brokers who may repackage the imagery and pass it on to their own end users. Interactions with a sample of end users found the following: users like MODIS Rapid Response imagery but do not want to be confined to pre-defined subsets; they want a broader selection of imagery and those with higher bandwidth want the capability to pull in imagery in to their own web-mapping or GIS applications. Users with lower bandwidth want the capability to define their own areas-of-interest for simple download of an image file. Users also expressed a desire to see historic as well as near-real time data, so they can compare the current situation to the recent past. Users want download capabilities to enable information to be shared quickly and easily. These and other findings are being fed back to EOSDIS developers who are creating tools and services to better meet user needs. The findings from users have been valuable in ensuring that developers are on track. The most recent offerings, available http://earthdata.nasa.gov/lance, are Worldview - a web-based client which provides capability to interactively browse full-resolution, global, near real-time satellite imagery from 50+ data products from LANCE, and the Global Imagery Browse Services (GIBS) which enables both users and brokers to pull the latest imagery in to their own web mapping

  10. HPLC fingerprint analysis combined with chemometrics for pattern recognition of ginger.

    Science.gov (United States)

    Feng, Xu; Kong, Weijun; Wei, Jianhe; Ou-Yang, Zhen; Yang, Meihua

    2014-03-01

    Ginger, the fresh rhizome of Zingiber officinale Rosc. (Zingiberaceae), has been used worldwide; however, for a long time, there has been no standard approbated internationally for its quality control. To establish an efficacious and combinational method and pattern recognition technique for quality control of ginger. A simple, accurate and reliable method based on high-performance liquid chromatography with photodiode array (HPLC-PDA) detection was developed for establishing the chemical fingerprints of 10 batches of ginger from different markets in China. The method was validated in terms of precision, reproducibility and stability; and the relative standard deviations were all less than 1.57%. On the basis of this method, the fingerprints of 10 batches of ginger samples were obtained, which showed 16 common peaks. Coupled with similarity evaluation software, the similarities between each fingerprint of the sample and the simulative mean chromatogram were in the range of 0.998-1.000. Then, the chemometric techniques, including similarity analysis, hierarchical clustering analysis and principal component analysis were applied to classify the ginger samples. Consistent results were obtained to show that ginger samples could be successfully classified into two groups. This study revealed that HPLC-PDA method was simple, sensitive and reliable for fingerprint analysis, and moreover, for pattern recognition and quality control of ginger.

  11. Effect of emodin on Candida albicans growth investigated by microcalorimetry combined with chemometric analysis.

    Science.gov (United States)

    Kong, W J; Wang, J B; Jin, C; Zhao, Y L; Dai, C M; Xiao, X H; Li, Z L

    2009-07-01

    Using the 3114/3115 thermal activity monitor (TAM) air isothermal microcalorimeter, ampoule mode, the heat output of Candida albicans growth at 37 degrees C was measured, and the effect of emodin on C. albicans growth was evaluated by microcalorimetry coupled with chemometric methods. The similarities between the heat flow power (HFP)-time curves of C. albicans growth affected by different concentrations of emodin were calculated by similarity analysis (SA). In the correspondence analysis (CA) diagram of eight quantitative parameters taken from the HFP-time curves, it could be deduced that emodin had definite dose-effect relationship as the distance between different concentrations of it increased along with the dosage and the effect. From the principal component analysis (PCA) on eight quantitative parameters, the action of emodin on C. albicans growth could be easily evaluated by analyzing the change of values of the main two parameters, growth rate constant k (2) and maximum power output P(2)(m). The coherent results of SA, CA, and PCA showed that emodin at different concentrations had different effects on C. albicans growth metabolism: A low concentration (0-10 microg ml(-1)) poorly inhibited the growth of C. albicans, and a high concentration (15-35 microg ml(-1)) could notably inhibit growth of this fungus. This work provided a useful idea of the combination of microcalorimetry and chemometric analysis for investigating the effect of drug and other compounds on microbes.

  12. 75 FR 5629 - NASA Advisory Council; Audit, Finance and Analysis Committee; Meeting

    Science.gov (United States)

    2010-02-03

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-018)] NASA Advisory Council; Audit... Analysis Committee of the NASA Advisory Council. DATES: Wednesday, February 17, 2010, 9 a.m.-4 p.m. EST. ADDRESSES: NASA Headquarters, 300 E Street, SW., Washington, DC 20456, Conference Room 8D48. FOR FURTHER...

  13. Opportunities, Traps and Sanctuaries: A Frame Analysis of Learned Societies. ASHE Annual Meeting 1979 Paper.

    Science.gov (United States)

    Bloland, Harland G.

    An analysis and comparison of two frames, "conventioneering" and "game," as experienced by convention goers is presented to provide a partial explanation of convention behavior and stress response. Many of the concepts discussed come directly from books by Erving Goffman. Frames are principles of organization that govern…

  14. Numerical analysis and field study of time dependent exergy-energy of a gas-steam combined cycle

    Directory of Open Access Journals (Sweden)

    Barari Bamdad

    2012-01-01

    Full Text Available In this study, time dependent exergy analysis of the Fars Combined Power Plant Cycle has been investigated. Exergy analysis has been used for investigating each part of actual combined cycle by considering irreversibility from Apr 2006 to Oct 2010. Performance analysis has been done for each part by evaluating exergy destruction in each month. By using of exergy analysis, aging of each part has been evaluated respect to time duration. In addition, the rate of lost work for each month has been calculated and variation of this parameter has been considered as a function of aging rate. Finally, effects of exergy destruction of each part have been investigated on exergy destruction of whole cycle. Entire analysis has been done for Unit 3 and 4 of gas turbine cycle which combined by Unit B of steam cycle in Fars Combined Power Plant Cycle located in Fars province in Iran.

  15. Environmental Decision Analysis: Meeting the Challenges of Making Good Decisions at CALFED

    Directory of Open Access Journals (Sweden)

    Claire D Tomkins

    2006-09-01

    Full Text Available We present a methodology to support decision making at CALFED based on the principles of decision analysis, an analytical approach to decision making designed to handle complex decisions involving both uncertainty and multiple dimensions of value. The impetus for such an approach is a recognized need to enhance communication between scientists and management and between program elements within CALFED. In addition, the environmental decision analysis framework supports both the explicit representation of uncertainty in the decision problem and communication about risk, important elements of most environmental management decisions. The decision analysis cycle consists of four phases: 1 formulate, 2 evaluate, 3 appraise, and 4 decide. In phase one, we identify the objectives and also the alternatives, or possible actions. To facilitate inter-comparison between proposed actions, we recommend formulation of a set of common metrics for CALFED. In our pilot study, we introduced common metrics for salinity, winter-run Chinook salmon survival, and habitat health. The second phase focuses on quantifying possible impacts on the set of metrics, drawing on existing data, model runs, and expert opinions. For the evaluation phase, we employ tools such as decision trees to assess the system-wide impacts of a given action. In the final phase, tools such as expected cost-benefit analysis, value contribution diagrams, and 3-D tradeoff plots aid communication between various stakeholders, scientists, and managers. While decision analysis provides a spectrum of decision support tools, we emphasize that it does not dictate a solution but rather enhances communication about tradeoffs associated with different actions.

  16. Speciation analysis of arsenic, chromium and selenium in aquatic media. Proceedings of a final research coordination meeting

    International Nuclear Information System (INIS)

    2007-03-01

    The initiation of the Coordinated Research Project (CRP) on Development and Validation of Speciation Analysis using Nuclear Techniques resulted from the recognition that knowledge of total element concentration does not provide adequate information to understand the effects of trace and heavy metals observed in the environment and in living systems. Their toxicity, bioavailability, physiological and metabolic processes, mobility and distribution are greatly dependent on the specific chemical form of the element. Speciation analysis has yet to be developed to its full potential for biochemical, clinical and environmental investigations and still more work is needed in the near future. Seven participants from seven countries participated in this CRP covering a range of analytical techniques including GC, HPLC, AAS, and ICP-MS. The first Research Coordination Meeting (RCM) of the Coordinated Research Project on the Development and Validation of Speciation Analysis using Nuclear Techniques was held at the Reactor Centre of the Jozef Stefan Institute, Podgorica (near Ljubljana), Slovenia, 20-23 June 2001. The second RCM was held at the Technical University of Vienna, 18-22 November 2002, where, in addition to the participants, two external researchers could present their views and experience in the field. The last RCM was held in Vienna, 26-29 April 2004, and this publication is a summary of the results achieved and presented at this last RCM. The participants have developed several new procedures for the reliable analysis of As, Cr, and Se species, mainly in aquatic media. A new instrument was designed and several recommendations for speciation analysis were issued. It is hoped that this publication will make a contribution to enhancing the awareness of the importance of speciation analysis and add to the reliability of speciation results in Member State laboratories

  17. Using variable combination population analysis for variable selection in multivariate calibration.

    Science.gov (United States)

    Yun, Yong-Huan; Wang, Wei-Ting; Deng, Bai-Chuan; Lai, Guang-Bi; Liu, Xin-bo; Ren, Da-Bing; Liang, Yi-Zeng; Fan, Wei; Xu, Qing-Song

    2015-03-03

    Variable (wavelength or feature) selection techniques have become a critical step for the analysis of datasets with high number of variables and relatively few samples. In this study, a novel variable selection strategy, variable combination population analysis (VCPA), was proposed. This strategy consists of two crucial procedures. First, the exponentially decreasing function (EDF), which is the simple and effective principle of 'survival of the fittest' from Darwin's natural evolution theory, is employed to determine the number of variables to keep and continuously shrink the variable space. Second, in each EDF run, binary matrix sampling (BMS) strategy that gives each variable the same chance to be selected and generates different variable combinations, is used to produce a population of subsets to construct a population of sub-models. Then, model population analysis (MPA) is employed to find the variable subsets with the lower root mean squares error of cross validation (RMSECV). The frequency of each variable appearing in the best 10% sub-models is computed. The higher the frequency is, the more important the variable is. The performance of the proposed procedure was investigated using three real NIR datasets. The results indicate that VCPA is a good variable selection strategy when compared with four high performing variable selection methods: genetic algorithm-partial least squares (GA-PLS), Monte Carlo uninformative variable elimination by PLS (MC-UVE-PLS), competitive adaptive reweighted sampling (CARS) and iteratively retains informative variables (IRIV). The MATLAB source code of VCPA is available for academic research on the website: http://www.mathworks.com/matlabcentral/fileexchange/authors/498750. Copyright © 2015 Elsevier B.V. All rights reserved.

  18. The index-flood and the GRADEX methods combination for flood frequency analysis.

    Science.gov (United States)

    Fuentes, Diana; Di Baldassarre, Giuliano; Quesada, Beatriz; Xu, Chong-Yu; Halldin, Sven; Beven, Keith

    2017-04-01

    Flood frequency analysis is used in many applications, including flood risk management, design of hydraulic structures, and urban planning. However, such analysis requires of long series of observed discharge data which are often not available in many basins around the world. In this study, we tested the usefulness of combining regional discharge and local precipitation data to estimate the event flood volume frequency curve for 63 catchments in Mexico, Central America and the Caribbean. This was achieved by combining two existing flood frequency analysis methods, the regionalization index-flood approach with the GRADEX method. For up to 10-years return period, similar shape of the scaled flood frequency curve for catchments with similar flood behaviour was assumed from the index-flood approach. For return periods larger than 10-years the probability distribution of rainfall and discharge volumes were assumed to be asymptotically and exponential-type functions with the same scale parameter from the GRADEX method. Results showed that if the mean annual flood (MAF), used as index-flood, is known, the index-flood approach performed well for up to 10 years return periods, resulting in 25% mean relative error in prediction. For larger return periods the prediction capability decreased but could be improved by the use of the GRADEX method. As the MAF is unknown at ungauged and short-period measured basins, we tested predicting the MAF using catchments climate-physical characteristics, and discharge statistics, the latter when observations were available for only 8 years. Only the use of discharge statistics resulted in acceptable predictions.

  19. Next-generation sequencing meets genetic diagnostics: development of a comprehensive workflow for the analysis of BRCA1 and BRCA2 genes

    Science.gov (United States)

    Feliubadaló, Lídia; Lopez-Doriga, Adriana; Castellsagué, Ester; del Valle, Jesús; Menéndez, Mireia; Tornero, Eva; Montes, Eva; Cuesta, Raquel; Gómez, Carolina; Campos, Olga; Pineda, Marta; González, Sara; Moreno, Victor; Brunet, Joan; Blanco, Ignacio; Serra, Eduard; Capellá, Gabriel; Lázaro, Conxi

    2013-01-01

    Next-generation sequencing (NGS) is changing genetic diagnosis due to its huge sequencing capacity and cost-effectiveness. The aim of this study was to develop an NGS-based workflow for routine diagnostics for hereditary breast and ovarian cancer syndrome (HBOCS), to improve genetic testing for BRCA1 and BRCA2. A NGS-based workflow was designed using BRCA MASTR kit amplicon libraries followed by GS Junior pyrosequencing. Data analysis combined Variant Identification Pipeline freely available software and ad hoc R scripts, including a cascade of filters to generate coverage and variant calling reports. A BRCA homopolymer assay was performed in parallel. A research scheme was designed in two parts. A Training Set of 28 DNA samples containing 23 unique pathogenic mutations and 213 other variants (33 unique) was used. The workflow was validated in a set of 14 samples from HBOCS families in parallel with the current diagnostic workflow (Validation Set). The NGS-based workflow developed permitted the identification of all pathogenic mutations and genetic variants, including those located in or close to homopolymers. The use of NGS for detecting copy-number alterations was also investigated. The workflow meets the sensitivity and specificity requirements for the genetic diagnosis of HBOCS and improves on the cost-effectiveness of current approaches. PMID:23249957

  20. Data analysis and integration of environmental sensors to meet human needs

    Science.gov (United States)

    Santamaria, Amilcare Francesco; De Rango, Floriano; Barletta, Domenico; Falbo, Domenico; Imbrogno, Alessandro

    2014-05-01

    Nowadays one of the main task of technology is to make people's life simpler and easier. Ambient intelligence is an emerging discipline that brings intelligence to environments making them sensitive to us. This discipline has developed following the spread of sensors devices, sensor networks, pervasive computing and artificial intelligence. In this work, we attempt to enhance the Internet Of Things (loT) with intelligence and environments exploring various interactions between humans' beings and the environment they live in. In particular, the core of the system is composed of an automation system, which is made up with a domotic control unit and several sensors installed in the environment. The task of the sensors is to collect information from the environment and to send them to the control unit. Once the information is collected, the core combines them in order to infer the most accurate human needs. The knowledge of human needs and the current environment status compose the inputs of the intelligence block whose main goal is to find the right automations to satisfy human needs in a real time way. The system also provides a Speech Recognition service which allow users to interact with the system by their voice so human speech can be considered as additional input for smart automatisms.

  1. Combining multiple regression and principal component analysis for accurate predictions for column ozone in Peninsular Malaysia

    Science.gov (United States)

    Rajab, Jasim M.; MatJafri, M. Z.; Lim, H. S.

    2013-06-01

    This study encompasses columnar ozone modelling in the peninsular Malaysia. Data of eight atmospheric parameters [air surface temperature (AST), carbon monoxide (CO), methane (CH4), water vapour (H2Ovapour), skin surface temperature (SSKT), atmosphere temperature (AT), relative humidity (RH), and mean surface pressure (MSP)] data set, retrieved from NASA's Atmospheric Infrared Sounder (AIRS), for the entire period (2003-2008) was employed to develop models to predict the value of columnar ozone (O3) in study area. The combined method, which is based on using both multiple regressions combined with principal component analysis (PCA) modelling, was used to predict columnar ozone. This combined approach was utilized to improve the prediction accuracy of columnar ozone. Separate analysis was carried out for north east monsoon (NEM) and south west monsoon (SWM) seasons. The O3 was negatively correlated with CH4, H2Ovapour, RH, and MSP, whereas it was positively correlated with CO, AST, SSKT, and AT during both the NEM and SWM season periods. Multiple regression analysis was used to fit the columnar ozone data using the atmospheric parameter's variables as predictors. A variable selection method based on high loading of varimax rotated principal components was used to acquire subsets of the predictor variables to be comprised in the linear regression model of the atmospheric parameter's variables. It was found that the increase in columnar O3 value is associated with an increase in the values of AST, SSKT, AT, and CO and with a drop in the levels of CH4, H2Ovapour, RH, and MSP. The result of fitting the best models for the columnar O3 value using eight of the independent variables gave about the same values of the R (≈0.93) and R2 (≈0.86) for both the NEM and SWM seasons. The common variables that appeared in both regression equations were SSKT, CH4 and RH, and the principal precursor of the columnar O3 value in both the NEM and SWM seasons was SSKT.

  2. Understanding consumption-related sucralose emissions - A conceptual approach combining substance-flow analysis with sampling analysis

    Energy Technology Data Exchange (ETDEWEB)

    Neset, Tina-Simone Schmid, E-mail: tina.schmid.neset@liu.se [Department of Water and Environmental Studies, Linkoeping University, SE-58183 Linkoeping (Sweden); Singer, Heinz; Longree, Philipp; Bader, Hans-Peter; Scheidegger, Ruth; Wittmer, Anita; Andersson, Jafet Clas Martin [Eawag, Swiss Federal Institute of Aquatic Science and Technology, Ueberlandstrasse 133, CH-8600 Duebendorf (Switzerland)

    2010-07-15

    This paper explores the potential of combining substance-flow modelling with water and wastewater sampling to trace consumption-related substances emitted through the urban wastewater. The method is exemplified on sucralose. Sucralose is a chemical sweetener that is 600 times sweeter than sucrose and has been on the European market since 2004. As a food additive, sucralose has recently increased in usage in a number of foods, such as soft drinks, dairy products, candy and several dietary products. In a field campaign, sucralose concentrations were measured in the inflow and outflow of the local wastewater treatment plant in Linkoeping, Sweden, as well as upstream and downstream of the receiving stream and in Lake Roxen. This allows the loads emitted from the city to be estimated. A method consisting of solid-phase extraction followed by liquid chromatography and high resolution mass spectrometry was used to quantify the sucralose in the collected surface and wastewater samples. To identify and quantify the sucralose sources, a consumption analysis of households including small business enterprises was conducted as well as an estimation of the emissions from the local food industry. The application of a simple model including uncertainty and sensitivity analysis indicates that at present not one large source but rather several small sources contribute to the load coming from households, small business enterprises and industry. This is in contrast to the consumption pattern seen two years earlier, which was dominated by one product. The inflow to the wastewater treatment plant decreased significantly from other measurements made two years earlier. The study shows that the combination of substance-flow modelling with the analysis of the loads to the receiving waters helps us to understand consumption-related emissions.

  3. The Multimorbidity Cluster Analysis Tool: Identifying Combinations and Permutations of Multiple Chronic Diseases Using a Record-Level Computational Analysis

    Directory of Open Access Journals (Sweden)

    Kathryn Nicholson

    2017-12-01

    Full Text Available Introduction: Multimorbidity, or the co-occurrence of multiple chronic health conditions within an individual, is an increasingly dominant presence and burden in modern health care systems.  To fully capture its complexity, further research is needed to uncover the patterns and consequences of these co-occurring health states.  As such, the Multimorbidity Cluster Analysis Tool and the accompanying Multimorbidity Cluster Analysis Toolkit have been created to allow researchers to identify distinct clusters that exist within a sample of participants or patients living with multimorbidity.  Development: The Tool and Toolkit were developed at Western University in London, Ontario, Canada.  This open-access computational program (JAVA code and executable file was developed and tested to support an analysis of thousands of individual records and up to 100 disease diagnoses or categories.  Application: The computational program can be adapted to the methodological elements of a research project, including type of data, type of chronic disease reporting, measurement of multimorbidity, sample size and research setting.  The computational program will identify all existing, and mutually exclusive, combinations and permutations within the dataset.  An application of this computational program is provided as an example, in which more than 75,000 individual records and 20 chronic disease categories resulted in the detection of 10,411 unique combinations and 24,647 unique permutations among female and male patients.  Discussion: The Tool and Toolkit are now available for use by researchers interested in exploring the complexities of multimorbidity.  Its careful use, and the comparison between results, will be valuable additions to the nuanced understanding of multimorbidity.

  4. Understanding consumption-related sucralose emissions - A conceptual approach combining substance-flow analysis with sampling analysis

    International Nuclear Information System (INIS)

    Neset, Tina-Simone Schmid; Singer, Heinz; Longree, Philipp; Bader, Hans-Peter; Scheidegger, Ruth; Wittmer, Anita; Andersson, Jafet Clas Martin

    2010-01-01

    This paper explores the potential of combining substance-flow modelling with water and wastewater sampling to trace consumption-related substances emitted through the urban wastewater. The method is exemplified on sucralose. Sucralose is a chemical sweetener that is 600 times sweeter than sucrose and has been on the European market since 2004. As a food additive, sucralose has recently increased in usage in a number of foods, such as soft drinks, dairy products, candy and several dietary products. In a field campaign, sucralose concentrations were measured in the inflow and outflow of the local wastewater treatment plant in Linkoeping, Sweden, as well as upstream and downstream of the receiving stream and in Lake Roxen. This allows the loads emitted from the city to be estimated. A method consisting of solid-phase extraction followed by liquid chromatography and high resolution mass spectrometry was used to quantify the sucralose in the collected surface and wastewater samples. To identify and quantify the sucralose sources, a consumption analysis of households including small business enterprises was conducted as well as an estimation of the emissions from the local food industry. The application of a simple model including uncertainty and sensitivity analysis indicates that at present not one large source but rather several small sources contribute to the load coming from households, small business enterprises and industry. This is in contrast to the consumption pattern seen two years earlier, which was dominated by one product. The inflow to the wastewater treatment plant decreased significantly from other measurements made two years earlier. The study shows that the combination of substance-flow modelling with the analysis of the loads to the receiving waters helps us to understand consumption-related emissions.

  5. Consensus strategy in genes prioritization and combined bioinformatics analysis for preeclampsia pathogenesis.

    Science.gov (United States)

    Tejera, Eduardo; Cruz-Monteagudo, Maykel; Burgos, Germán; Sánchez, María-Eugenia; Sánchez-Rodríguez, Aminael; Pérez-Castillo, Yunierkis; Borges, Fernanda; Cordeiro, Maria Natália Dias Soeiro; Paz-Y-Miño, César; Rebelo, Irene

    2017-08-08

    Preeclampsia is a multifactorial disease with unknown pathogenesis. Even when recent studies explored this disease using several bioinformatics tools, the main objective was not directed to pathogenesis. Additionally, consensus prioritization was proved to be highly efficient in the recognition of genes-disease association. However, not information is available about the consensus ability to early recognize genes directly involved in pathogenesis. Therefore our aim in this study is to apply several theoretical approaches to explore preeclampsia; specifically those genes directly involved in the pathogenesis. We firstly evaluated the consensus between 12 prioritization strategies to early recognize pathogenic genes related to preeclampsia. A communality analysis in the protein-protein interaction network of previously selected genes was done including further enrichment analysis. The enrichment analysis includes metabolic pathways as well as gene ontology. Microarray data was also collected and used in order to confirm our results or as a strategy to weight the previously enriched pathways. The consensus prioritized gene list was rationally filtered to 476 genes using several criteria. The communality analysis showed an enrichment of communities connected with VEGF-signaling pathway. This pathway is also enriched considering the microarray data. Our result point to VEGF, FLT1 and KDR as relevant pathogenic genes, as well as those connected with NO metabolism. Our results revealed that consensus strategy improve the detection and initial enrichment of pathogenic genes, at least in preeclampsia condition. Moreover the combination of the first percent of the prioritized genes with protein-protein interaction network followed by communality analysis reduces the gene space. This approach actually identifies well known genes related with pathogenesis. However, genes like HSP90, PAK2, CD247 and others included in the first 1% of the prioritized list need to be further

  6. Meeting Disorders.

    Science.gov (United States)

    Yager, Joel; Katzman, Jeffrey W

    2017-12-01

    Although meetings are central to organizational work, considerable time devoted to meetings in Academic Health Centers appears to be unproductively spent. The primary purposes of this article are to delineate and describe Meeting Disorders, pathological processes resulting in these inefficient and ineffective scenarios, and Meeting Fatigue Disorder (MFD), a clinical syndrome. The paper also offers preliminary approaches to remedies. The authors integrate observations made during tens of thousands of hours in administrative meetings in academic medical settings with information in the literature regarding the nature, causes and potential interventions for dysfunctional groups and meetings. Meeting Disorders, resulting from distinct pathologies of leadership and organization, constitute prevalent subgroups of the bureaucrapathologies, pathological conditions caused by dysfunctional bureaucratic processes that generate excesses of wasted time, effort, and other resources. These disorders also generate frustration and demoralization among participants, contributing to professional burnout. Meeting Fatigue Disorder (MFD) is a subjective condition that develops in individuals who overdose on these experiences and may reflect one manifestation of burnout. Meeting disorders and Meeting Fatigue Disorder occur commonly in bureaucratic life. Resources and potential remedies are available to help ameliorate their more deleterious effects.

  7. Multidisciplinary Inverse Reliability Analysis Based on Collaborative Optimization with Combination of Linear Approximations

    Directory of Open Access Journals (Sweden)

    Xin-Jia Meng

    2015-01-01

    Full Text Available Multidisciplinary reliability is an important part of the reliability-based multidisciplinary design optimization (RBMDO. However, it usually has a considerable amount of calculation. The purpose of this paper is to improve the computational efficiency of multidisciplinary inverse reliability analysis. A multidisciplinary inverse reliability analysis method based on collaborative optimization with combination of linear approximations (CLA-CO is proposed in this paper. In the proposed method, the multidisciplinary reliability assessment problem is first transformed into a problem of most probable failure point (MPP search of inverse reliability, and then the process of searching for MPP of multidisciplinary inverse reliability is performed based on the framework of CLA-CO. This method improves the MPP searching process through two elements. One is treating the discipline analyses as the equality constraints in the subsystem optimization, and the other is using linear approximations corresponding to subsystem responses as the replacement of the consistency equality constraint in system optimization. With these two elements, the proposed method realizes the parallel analysis of each discipline, and it also has a higher computational efficiency. Additionally, there are no difficulties in applying the proposed method to problems with nonnormal distribution variables. One mathematical test problem and an electronic packaging problem are used to demonstrate the effectiveness of the proposed method.

  8. Combining Different Tools for EEG Analysis to Study the Distributed Character of Language Processing

    Directory of Open Access Journals (Sweden)

    Armando Freitas da Rocha

    2015-01-01

    Full Text Available Recent studies on language processing indicate that language cognition is better understood if assumed to be supported by a distributed intelligent processing system enrolling neurons located all over the cortex, in contrast to reductionism that proposes to localize cognitive functions to specific cortical structures. Here, brain activity was recorded using electroencephalogram while volunteers were listening or reading small texts and had to select pictures that translate meaning of these texts. Several techniques for EEG analysis were used to show this distributed character of neuronal enrollment associated with the comprehension of oral and written descriptive texts. Low Resolution Tomography identified the many different sets (si of neurons activated in several distinct cortical areas by text understanding. Linear correlation was used to calculate the information H(ei provided by each electrode of the 10/20 system about the identified si. H(ei Principal Component Analysis (PCA was used to study the temporal and spatial activation of these sources si. This analysis evidenced 4 different patterns of H(ei covariation that are generated by neurons located at different cortical locations. These results clearly show that the distributed character of language processing is clearly evidenced by combining available EEG technologies.

  9. Combined optimal-pathlengths method for near-infrared spectroscopy analysis

    International Nuclear Information System (INIS)

    Liu Rong; Xu Kexin; Lu Yanhui; Sun Huili

    2004-01-01

    Near-infrared (NIR) spectroscopy is a rapid, reagent-less and nondestructive analytical technique, which is being increasingly employed for quantitative application in chemistry, pharmaceutics and food industry, and for the optical analysis of biological tissue. The performance of NIR technology greatly depends on the abilities to control and acquire data from the instrument and to calibrate and analyse data. Optical pathlength is a key parameter of the NIR instrument, which has been thoroughly discussed in univariate quantitative analysis in the presence of photometric errors. Although multiple wavelengths can provide more chemical information, it is difficult to determine a single pathlength that is suitable for each wavelength region. A theoretical investigation of a selection procedure for multiple pathlengths, called the combined optimal-pathlengths (COP) method, is identified in this paper and an extensive comparison with the single pathlength method is also performed on simulated and experimental NIR spectral data sets. The results obtained show that the COP method can greatly improve the prediction accuracy in NIR spectroscopy quantitative analysis

  10. Bayesian inference – a way to combine statistical data and semantic analysis meaningfully

    Directory of Open Access Journals (Sweden)

    Eila Lindfors

    2011-11-01

    Full Text Available This article focuses on presenting the possibilities of Bayesian modelling (Finite Mixture Modelling in the semantic analysis of statistically modelled data. The probability of a hypothesis in relation to the data available is an important question in inductive reasoning. Bayesian modelling allows the researcher to use many models at a time and provides tools to evaluate the goodness of different models. The researcher should always be aware that there is no such thing as the exact probability of an exact event. This is the reason for using probabilistic models. Each model presents a different perspective on the phenomenon in focus, and the researcher has to choose the most probable model with a view to previous research and the knowledge available.The idea of Bayesian modelling is illustrated here by presenting two different sets of data, one from craft science research (n=167 and the other (n=63 from educational research (Lindfors, 2007, 2002. The principles of how to build models and how to combine different profiles are described in the light of the research mentioned.Bayesian modelling is an analysis based on calculating probabilities in relation to a specific set of quantitative data. It is a tool for handling data and interpreting it semantically. The reliability of the analysis arises from an argumentation of which model can be selected from the model space as the basis for an interpretation, and on which arguments.Keywords: method, sloyd, Bayesian modelling, student teachersURN:NBN:no-29959

  11. Verification of combined thermal-hydraulic and heat conduction analysis code FLOWNET/TRUMP

    International Nuclear Information System (INIS)

    Maruyama, Soh; Fujimoto, Nozomu; Sudo, Yukio; Kiso, Yoshihiro; Murakami, Tomoyuki.

    1988-09-01

    This report presents the verification results of the combined thermal-hydraulic and heat conduction analysis code, FLOWNET/TRUMP which has been utilized for the core thermal hydraulic design, especially for the analysis of flow distribution among fuel block coolant channels, the determination of thermal boundary conditions for fuel block stress analysis and the estimation of fuel temperature in the case of fuel block coolant channel blockage accident in the design of the High Temperature Engineering Test Reactor(HTTR), which the Japan Atomic Energy Research Institute has been planning to construct in order to establish basic technologies for future advanced very high temperature gas-cooled reactors and to be served as an irradiation test reactor for promotion of innovative high temperature new frontier technologies. The verification of the code was done through the comparison between the analytical results and experimental results of the Helium Engineering Demonstration Loop Multi-channel Test Section(HENDEL T 1-M ) with simulated fuel rods and fuel blocks. (author)

  12. Verification of combined thermal-hydraulic and heat conduction analysis code FLOWNET/TRUMP

    Science.gov (United States)

    Maruyama, Soh; Fujimoto, Nozomu; Kiso, Yoshihiro; Murakami, Tomoyuki; Sudo, Yukio

    1988-09-01

    This report presents the verification results of the combined thermal-hydraulic and heat conduction analysis code, FLOWNET/TRUMP which has been utilized for the core thermal hydraulic design, especially for the analysis of flow distribution among fuel block coolant channels, the determination of thermal boundary conditions for fuel block stress analysis and the estimation of fuel temperature in the case of fuel block coolant channel blockage accident in the design of the High Temperature Engineering Test Reactor(HTTR), which the Japan Atomic Energy Research Institute has been planning to construct in order to establish basic technologies for future advanced very high temperature gas-cooled reactors and to be served as an irradiation test reactor for promotion of innovative high temperature new frontier technologies. The verification of the code was done through the comparison between the analytical results and experimental results of the Helium Engineering Demonstration Loop Multi-channel Test Section(HENDEL T(sub 1-M)) with simulated fuel rods and fuel blocks.

  13. Analysis of combining ability over environments in diallel crosses of maize (Zea mays

    Directory of Open Access Journals (Sweden)

    M.A. Murtadha

    2018-01-01

    Full Text Available Utilization of stress tolerant maize is the key to sustainable production and food security, and hence studies were conducted at Dirab Research Station, Riyadh, Saudi Arabia, from 2009 to 2010 to estimate General Combining Ability (GCA, Specific Combining Ability (SCA and their interactions with environment. Non-reciprocal diallel crossing was performed among six inbreds. The inbreds, 15 F1 hybrids and two checks were evaluated in split plot design. Regulated irrigation commenced before tasselling and stopped before grain filling stage, using Food and Agriculture Organization (FAO evaporation pan as guide. Water was applied when pan reading was at 50, 70 and 90 in. to create E1, E2 and E3 environments respectively. Data were analyzed using method 3 of Gardner and Eberhart. Analysis of variance showed highly significant variance (P ⩽ 0.01 among almost all sources of variation. High significance GCA and SCA observed revealed the importance of both additive and non-additive genetic actions, while low GCA/SCA implied importance of dominant effects of gene. Anthesis-silking interval (ASI was the most affected trait by water deficit indicating that selection for tolerance could be based on short ASI. Performance per se of the genotypes reveals the importance of hybrids with P1 and P6 but failed to indicate their suitability as combiners. The KSU 6–47 had highest significant GCA for grain yield under E1 and E2. KSU 3–69 had the lowest significant negative GCA for days to tasselling, while cross KSU 6–47 × KSU 3–69 with high SCA for grain yield and 1000-kernel weight under all environments suggested their usefulness for improvement.

  14. Analysis of the effects of combining air separation with combustion in a zero emissions (ZEITMOP) cycle

    International Nuclear Information System (INIS)

    Foy, Kirsten; McGovern, Jim

    2007-01-01

    The ZEITMOP cycle is a zero emissions (oxyfuel) power plant cycle proposed by Evgeny Yantovski that uses oxygen ion transport membranes to extract the oxygen required for combustion from air. A current proposed configuration of the cycle requires an oxygen ion transport membrane air separation unit operating at 920 deg. C and a separate combustion chamber operating at 1400 deg. C. If oxygen is consumed by a chemical reaction on the permeate side of an oxygen transport membrane, the oxygen flux is larger, so the air separation unit can be physically smaller. In addition, if this reaction is exothermic, the air separation unit is heated by the reaction, requiring no additional heating. Combustion fulfils both of these requirements, so combustion in the oxygen transport membrane air separation unit would allow a smaller air separation unit, which would also act as a combustion chamber. Unfortunately, a combustion temperature of 1400 deg. C will damage most oxygen transport membranes available today. However, new materials are continually being developed and investigated, so it may be possible to have an oxygen transport membrane chamber operating at 1400 deg. C in the short to medium term future. Alternatively the combustion chamber may be cooled, allowing it to operate at more realistic temperatures for currently available oxygen transport membranes. Controlling the operation temperature of the combined unit requires changing the mass flow rates of various streams of fluid in the cycle. This will have an effect on the work and heat transfers in the cycle. It is possible to calculate the theoretical effects of these changes in temperature. This paper presents an analysis investigating the impact of combining the air separator and the combustion chamber. The efficiency of the cycle was calculated at various operation temperatures for the combined oxygen transport membrane combustion chamber. The results were compared to the efficiency of the current cycle. The changes

  15. Social Media Meets Big Urban Data: A Case Study of Urban Waterlogging Analysis

    Directory of Open Access Journals (Sweden)

    Ningyu Zhang

    2016-01-01

    Full Text Available With the design and development of smart cities, opportunities as well as challenges arise at the moment. For this purpose, lots of data need to be obtained. Nevertheless, circumstances vary in different cities due to the variant infrastructures and populations, which leads to the data sparsity. In this paper, we propose a transfer learning method for urban waterlogging disaster analysis, which provides the basis for traffic management agencies to generate proactive traffic operation strategies in order to alleviate congestion. Existing work on urban waterlogging mostly relies on past and current conditions, as well as sensors and cameras, while there may not be a sufficient number of sensors to cover the relevant areas of a city. To this end, it would be helpful if we could transfer waterlogging. We examine whether it is possible to use the copious amounts of information from social media and satellite data to improve urban waterlogging analysis. Moreover, we analyze the correlation between severity, road networks, terrain, and precipitation. Moreover, we use a multiview discriminant transfer learning method to transfer knowledge to small cities. Experimental results involving cities in China and India show that our proposed framework is effective.

  16. Social Media Meets Big Urban Data: A Case Study of Urban Waterlogging Analysis.

    Science.gov (United States)

    Zhang, Ningyu; Chen, Huajun; Chen, Jiaoyan; Chen, Xi

    2016-01-01

    With the design and development of smart cities, opportunities as well as challenges arise at the moment. For this purpose, lots of data need to be obtained. Nevertheless, circumstances vary in different cities due to the variant infrastructures and populations, which leads to the data sparsity. In this paper, we propose a transfer learning method for urban waterlogging disaster analysis, which provides the basis for traffic management agencies to generate proactive traffic operation strategies in order to alleviate congestion. Existing work on urban waterlogging mostly relies on past and current conditions, as well as sensors and cameras, while there may not be a sufficient number of sensors to cover the relevant areas of a city. To this end, it would be helpful if we could transfer waterlogging. We examine whether it is possible to use the copious amounts of information from social media and satellite data to improve urban waterlogging analysis. Moreover, we analyze the correlation between severity, road networks, terrain, and precipitation. Moreover, we use a multiview discriminant transfer learning method to transfer knowledge to small cities. Experimental results involving cities in China and India show that our proposed framework is effective.

  17. Artificial intelligence/fuzzy logic method for analysis of combined signals from heavy metal chemical sensors

    International Nuclear Information System (INIS)

    Turek, M.; Heiden, W.; Riesen, A.; Chhabda, T.A.; Schubert, J.; Zander, W.; Krueger, P.; Keusgen, M.; Schoening, M.J.

    2009-01-01

    The cross-sensitivity of chemical sensors for several metal ions resembles in a way the overlapping sensitivity of some biological sensors, like the optical colour receptors of human retinal cone cells. While it is difficult to assign crisp classification values to measurands based on complex overlapping sensory signals, fuzzy logic offers a possibility to mathematically model such systems. Current work goes into the direction of mixed heavy metal solutions and the combination of fuzzy logic with heavy metal-sensitive, silicon-based chemical sensors for training scenarios of arbitrary sensor/probe combinations in terms of an electronic tongue. Heavy metals play an important role in environmental analysis. As trace elements as well as water impurities released from industrial processes they occur in the environment. In this work, the development of a new fuzzy logic method based on potentiometric measurements performed with three different miniaturised chalcogenide glass sensors in different heavy metal solutions will be presented. The critical validation of the developed fuzzy logic program will be demonstrated by means of measurements in unknown single- and multi-component heavy metal solutions. Limitations of this program and a comparison between calculated and expected values in terms of analyte composition and heavy metal ion concentration will be shown and discussed.

  18. Thermo-dynamic analysis and simulation of a combined air and hydro energy storage (CAHES) system

    International Nuclear Information System (INIS)

    Bi, Xianyun; Liu, Pei; Li, Zheng

    2016-01-01

    Large-scale energy storage is essential for the stability of a grid, especially for those with large proportion of intermittent renewable energy sources. The efficiency of a conventional compressed air energy storage (CAES) technology is limited by compression heat loss and changing working conditions. In this manuscript, a combined air and hydro energy storage (CAHES) system is proposed, which realizes a higher exergy efficiency compared with conventional CAES systems by reducing compression heat losses and addressing issues of changing working conditions through thermal compensation from solar radiation. The configuration and two operating modes of the proposed CAHES system are firstly introduced, followed by theoretical analysis and numerical simulation under different operating modes to analyze system performances. Impacts of external and internal factors on the system performances are analyzed. The practical feasibility of the system is also investigated. Results show that the exergy efficiency of the system reaches approximately 50%, whilst the charging electricity ratio reaches over 80%. - Highlights: • A combined air and hydro energy storage system is proposed. • High exergy efficiency is achieved and consumption of fossil fuel is eliminated. • The system performance is affected by compression ratio and solar radiation.

  19. Analysis of the Accuracy of Beidou Combined Orbit Determination Enhanced by LEO and ISL

    Directory of Open Access Journals (Sweden)

    FENG Laiping

    2017-05-01

    Full Text Available In order to improve the precision of BeiDou orbit determination under the conditions of regional ground monitoring station and make good use of increasingly rich on-board data and upcoming ISL technology, a method of BeiDou precision orbit determination is proposed which combines the use of ground monitoring stations data, low earth orbit satellite(LEOs data and Inter-Satellite Link(ISL data. The effects of assisting data of LEOs and ISL on the precision orbit determination of navigation satellite are discussed. Simulation analysis is carried out mainly from the number of LEOs, orbit slot configuration and ISL. The results show that the orbit precision of BeiDou will greatly improve about 73% with a small number of LEOs, while improvement of clock bias is not remarkable; the uniform orbit slot configuration of the same number of LEOs has a modest effect on the accuracy of combined orbit determination; compared with LEOs, the increase of ISL will significantly improve the accuracy of orbit determination with a higher efficiency.

  20. Combined Analysis of Plasma Amphiregulin and Heregulin Predicts Response to Cetuximab in Metastatic Colorectal Cancer.

    Directory of Open Access Journals (Sweden)

    Kimio Yonesaka

    Full Text Available Amphiregulin, a ligand of the epidermal growth factor receptor (EGFR, is associated with the efficacy of cetuximab, an antibody against EGFR, as treatment for colorectal cancer (CRC. In contrast, the HER3 ligand heregulin correlates with cetuximab resistance. In this study, we evaluated how the combined levels of circulating amphiregulin and heregulin affect clinical outcomes in patients who receive cetuximab as therapy against advanced CRC.Plasma levels of amphiregulin and heregulin were measured by enzyme-linked immunosorbent assay in 50 patients with CRC in a training cohort, and in 10 patients in a validation cohort. The combined expression was then assessed with clinical outcome after receiver operating characteristics analysis.Overall response rate was 26%, and median progression-free survival was 110 days in the training cohort. Patients with high amphiregulin and low heregulin had significantly higher objective response rate at 58% and significantly longer progression-free survival of 216 days. This result was confirmed in the validation cohort.A subgroup of CRC patients with high amphiregulin and low heregulin respond to cetuximab therapy better than other patients.

  1. Bayesian analysis for erosion modelling of sediments in combined sewer systems.

    Science.gov (United States)

    Kanso, A; Chebbo, G; Tassin, B

    2005-01-01

    Previous research has confirmed that the sediments at the bed of combined sewer systems are the main source of particulate and organic pollution during rain events contributing to combined sewer overflows. However, existing urban stormwater models utilize inappropriate sediment transport formulas initially developed from alluvial hydrodynamics. Recently, a model has been formulated and profoundly assessed based on laboratory experiments to simulate the erosion of sediments in sewer pipes taking into account the increase in strength with depth in the weak layer of deposits. In order to objectively evaluate this model, this paper presents a Bayesian analysis of the model using field data collected in sewer pipes in Paris under known hydraulic conditions. The test has been performed using a MCMC sampling method for calibration and uncertainty assessment. Results demonstrate the capacity of the model to reproduce erosion as a direct response to the increase in bed shear stress. This is due to the model description of the erosional strength in the deposits and to the shape of the measured bed shear stress. However, large uncertainties in some of the model parameters suggest that the model could be over-parameterised and necessitates a large amount of informative data for its calibration.

  2. Torque Characteristic Analysis of a Transverse Flux Motor Using a Combined-Type Stator Core

    Directory of Open Access Journals (Sweden)

    Xiaobao Yang

    2016-11-01

    Full Text Available An external rotor transverse flux motor using a combined-type stator core is proposed for a direct drive application in this paper. The stator core is combined by two kinds of components that can both be manufactured conveniently by generic laminated silicon steel used in traditional motors. The motor benefits from the predominance of low manufacturing cost and low iron loss by using a silicon-steel sheet. Firstly, the basic structure and operation principles of the proposed motor are introduced. Secondly, the expressions of the electromagnetic torque and the cogging torque are deduced by theoretical analysis. Thirdly, the basic characteristics such as permanent magnet flux linkage, no-load back electromotive force, cogging torque and electromagnetic torque are analyzed by a three-dimensional finite element method (3D FEM. Then, the influence of structure parameters on the torque density is investigated, which provides a useful foundation for optimum design of the novel motor. Finally, the torque density of the proposed motor is calculated and discussed, and the result shows that the proposed motor in this paper can provide considerable torque density by using few permanent magnets.

  3. Artificial intelligence/fuzzy logic method for analysis of combined signals from heavy metal chemical sensors

    Energy Technology Data Exchange (ETDEWEB)

    Turek, M. [Institute of Nano- and Biotechnologies (INB), Aachen University of Applied Sciences, Campus Juelich, Juelich (Germany); Institute of Bio- and Nanosystems (IBN), Research Centre Juelich GmbH, Juelich (Germany); Heiden, W.; Riesen, A. [Bonn-Rhein-Sieg University of Applied Sciences, Sankt Augustin (Germany); Chhabda, T.A. [Institute of Nano- and Biotechnologies (INB), Aachen University of Applied Sciences, Campus Juelich, Juelich (Germany); Schubert, J.; Zander, W. [Institute of Bio- and Nanosystems (IBN), Research Centre Juelich GmbH, Juelich (Germany); Krueger, P. [Institute of Biochemistry and Molecular Biology, RWTH Aachen, Aachen (Germany); Keusgen, M. [Institute for Pharmaceutical Chemistry, Philipps-University Marburg, Marburg (Germany); Schoening, M.J. [Institute of Nano- and Biotechnologies (INB), Aachen University of Applied Sciences, Campus Juelich, Juelich (Germany); Institute of Bio- and Nanosystems (IBN), Research Centre Juelich GmbH, Juelich (Germany)], E-mail: m.j.schoening@fz-juelich.de

    2009-10-30

    The cross-sensitivity of chemical sensors for several metal ions resembles in a way the overlapping sensitivity of some biological sensors, like the optical colour receptors of human retinal cone cells. While it is difficult to assign crisp classification values to measurands based on complex overlapping sensory signals, fuzzy logic offers a possibility to mathematically model such systems. Current work goes into the direction of mixed heavy metal solutions and the combination of fuzzy logic with heavy metal-sensitive, silicon-based chemical sensors for training scenarios of arbitrary sensor/probe combinations in terms of an electronic tongue. Heavy metals play an important role in environmental analysis. As trace elements as well as water impurities released from industrial processes they occur in the environment. In this work, the development of a new fuzzy logic method based on potentiometric measurements performed with three different miniaturised chalcogenide glass sensors in different heavy metal solutions will be presented. The critical validation of the developed fuzzy logic program will be demonstrated by means of measurements in unknown single- and multi-component heavy metal solutions. Limitations of this program and a comparison between calculated and expected values in terms of analyte composition and heavy metal ion concentration will be shown and discussed.

  4. Identifying Natural syNergist from Pongamia pinnata Using High-Speed Counter-Current Chromatography Combined with Isobolographic Analysis

    Directory of Open Access Journals (Sweden)

    Hao Yin

    2017-03-01

    Full Text Available For identifying the synergistic compounds from Pongamia pinnata, an approach based on high-speed counter-current chromatography (HSCCC combined with isobolographic analysis was designed to detect the synergistic effects in the complex mixture [...

  5. A Pilot Study on the Combination of Applied Behavior Analysis and Bumetanide Treatment for Children with Autism

    NARCIS (Netherlands)

    Du, L.; Shan, L.; Wang, B.; Li, H.; Xu, Z.; Staal, W.G.; Jia, F.

    2015-01-01

    OBJECTIVE: The purpose of this study was to investigate the therapeutic effects of combined bumetanide and applied behavior analysis (ABA) treatment in children with autism. METHODS: Sixty children diagnosed with autism according to the International Classification of Diseases, Tenth Revision

  6. A Novel approach for predicting monthly water demand by combining singular spectrum analysis with neural networks

    Science.gov (United States)

    Zubaidi, Salah L.; Dooley, Jayne; Alkhaddar, Rafid M.; Abdellatif, Mawada; Al-Bugharbee, Hussein; Ortega-Martorell, Sandra

    2018-06-01

    Valid and dependable water demand prediction is a major element of the effective and sustainable expansion of municipal water infrastructures. This study provides a novel approach to quantifying water demand through the assessment of climatic factors, using a combination of a pretreatment signal technique, a hybrid particle swarm optimisation algorithm and an artificial neural network (PSO-ANN). The Singular Spectrum Analysis (SSA) technique was adopted to decompose and reconstruct water consumption in relation to six weather variables, to create a seasonal and stochastic time series. The results revealed that SSA is a powerful technique, capable of decomposing the original time series into many independent components including trend, oscillatory behaviours and noise. In addition, the PSO-ANN algorithm was shown to be a reliable prediction model, outperforming the hybrid Backtracking Search Algorithm BSA-ANN in terms of fitness function (RMSE). The findings of this study also support the view that water demand is driven by climatological variables.

  7. Thermal-CFD Analysis of Combined Solar-Nuclear Cycle Systems.

    Energy Technology Data Exchange (ETDEWEB)

    Fathi, Nima [Univ. of New Mexico, Albuquerque, NM (United States); McDaniel, Patrick [Univ. of New Mexico, Albuquerque, NM (United States); Vorobieff, Peter [Univ. of New Mexico, Albuquerque, NM (United States); de Oliveira, Cassiano [Univ. of New Mexico, Albuquerque, NM (United States); Rodriguez, Salvador B. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Aleyasin, Seyed Sobhan [Univ. of Manitoba (Canada)

    2015-09-01

    The aim of this paper is evaluating the efficiency of a novel combined solar-nuclear cycle. CFD-Thermal analysis is performed to apply the available surplus heat from the nuclear cycle and measure the available kinetic energy of air for the turbine of a solar chimney power plant system (SCPPS). The presented idea helps to decrease the thermal pollution and handle the water shortage supply for water plant by replacing the cooling tower by solar chimney power plant to get the surplus heat from the available warm air in the secondary loop of the reactor. By applying this idea to a typical 1000 MW nuclear power plant with a 0.33 thermal efficiency, we can increase it to 0.39.

  8. COMBINING PCA ANALYSIS AND ARTIFICIAL NEURAL NETWORKS IN MODELLING ENTREPRENEURIAL INTENTIONS OF STUDENTS

    Directory of Open Access Journals (Sweden)

    Marijana Zekić-Sušac

    2013-02-01

    Full Text Available Despite increased interest in the entrepreneurial intentions and career choices of young adults, reliable prediction models are yet to be developed. Two nonparametric methods were used in this paper to model entrepreneurial intentions: principal component analysis (PCA and artificial neural networks (ANNs. PCA was used to perform feature extraction in the first stage of modelling, while artificial neural networks were used to classify students according to their entrepreneurial intentions in the second stage. Four modelling strategies were tested in order to find the most efficient model. Dataset was collected in an international survey on entrepreneurship self-efficacy and identity. Variables describe students’ demographics, education, attitudes, social and cultural norms, self-efficacy and other characteristics. The research reveals benefits from the combination of the PCA and ANNs in modeling entrepreneurial intentions, and provides some ideas for further research.

  9. Cladistic analysis of Bantu languages: a new tree based on combined lexical and grammatical data

    Science.gov (United States)

    Rexová, Kateřina; Bastin, Yvonne; Frynta, Daniel

    2006-04-01

    The phylogeny of the Bantu languages is reconstructed by application of the cladistic methodology to the combined lexical and grammatical data (87 languages, 144 characters). A maximum parsimony tree and Bayesian analysis supported some previously recognized clades, e.g., that of eastern and southern Bantu languages. Moreover, the results revealed that Bantu languages south and east of the equatorial forest are probably monophyletic. It suggests an unorthodox scenario of Bantu expansion including (after initial radiation in their homelands and neighboring territories) just a single passage through rainforest areas followed by a subsequent divergence into major clades. The likely localization of this divergence is in the area west of the Great Lakes. It conforms to the view that demographic expansion and dispersal throughout the dry-forests and savanna regions of subequatorial Africa was associated with the acquisition of new technologies (iron metallurgy and grain cultivation).

  10. Combined Structural Optimization and Aeroelastic Analysis of a Vertical Axis Wind Turbine

    DEFF Research Database (Denmark)

    Roscher, Björn; Ferreira, Carlos Simao; Bernhammer, Lars O.

    2015-01-01

    Floating offshore wind energy poses challenges on the turbine design. A possible solution is vertical axis wind turbines, which are possibly easier to scale-up and require less components (lower maintenance) and a smaller floating structure than horizontal axis wind turbines. This paper presents...... a structural optimization and aeroelastic analysis of an optimized Troposkein vertical axis wind turbine to minimize the relation between the rotor mass and the swept area. The aeroelastic behavior of the different designs has been analyzed using a modified version of the HAWC2 code with the Actuator Cylinder...... model to compute the aerodynamics of the vertical axis wind turbine. The combined shape and topology optimization of a vertical axis wind turbine show a minimum mass to area ratio of 1.82 kg/m2 for blades with varying blade sections from a NACA 0040 at the attachment points to a NACA 0015...

  11. Heart failure analysis dashboard for patient's remote monitoring combining multiple artificial intelligence technologies.

    Science.gov (United States)

    Guidi, G; Pettenati, M C; Miniati, R; Iadanza, E

    2012-01-01

    In this paper we describe an Heart Failure analysis Dashboard that, combined with a handy device for the automatic acquisition of a set of patient's clinical parameters, allows to support telemonitoring functions. The Dashboard's intelligent core is a Computer Decision Support System designed to assist the clinical decision of non-specialist caring personnel, and it is based on three functional parts: Diagnosis, Prognosis, and Follow-up management. Four Artificial Intelligence-based techniques are compared for providing diagnosis function: a Neural Network, a Support Vector Machine, a Classification Tree and a Fuzzy Expert System whose rules are produced by a Genetic Algorithm. State of the art algorithms are used to support a score-based prognosis function. The patient's Follow-up is used to refine the diagnosis.

  12. Aero-Thermo-Structural Analysis of Inlet for Rocket Based Combined Cycle Engines

    Science.gov (United States)

    Shivakumar, K. N.; Challa, Preeti; Sree, Dave; Reddy, Dhanireddy R. (Technical Monitor)

    2000-01-01

    NASA has been developing advanced space transportation concepts and technologies to make access to space less costly. One such concept is the reusable vehicles with short turn-around times. The NASA Glenn Research Center's concept vehicle is the Trailblazer powered by a rocket-based combined cycle (RBCC) engine. Inlet is one of the most important components of the RBCC engine. This paper presents fluid flow, thermal, and structural analysis of the inlet for Mach 6 free stream velocity for fully supersonic and supercritical with backpressure conditions. The results concluded that the fully supersonic condition was the most severe case and the largest stresses occur in the ceramic matrix composite layer of the inlet cowl. The maximum tensile and the compressive stresses were at least 3.8 and 3.4, respectively, times less than the associated material strength.

  13. Combination of torsional, rotational and translational responses in the seismic analysis of a nuclear power plant

    International Nuclear Information System (INIS)

    Morrone, A.

    1979-01-01

    A particular type of seismic analysis performed on the Nuclear Island Buildings (NIB) complex of a nuclear power plant and the methods developed to combine torsional, rotational and translational responses are described. The NIB complex analyzed consists of various buildings supported on a common foundation mat and tied together from the underground foundation to the roof levels. Three independent building mathematical models were used for the three components of the earthquake with a lumped-mass method utilizing direct integration of the coupled equations of motion. The input ground acceleration time histories were based on three 20 s long statistically independent records whose normalized response spectra enveloped those of Regulatory Guide 1.60. A linear stochastic model was used to generate these records which simulated strong motion earthquakes. Due to site characteristics, the soil material properties were calculated considering different ranges of soil moduli below and above the foundation. (orig.)

  14. Combination of torsional, rotational and translational responses in the seismic analysis of a nuclear power plant

    International Nuclear Information System (INIS)

    Morrone, A.; Sigal, G.B.

    1979-01-01

    A particular type of seismic analysis performed on the Nuclear Island Buildings (NIB) complex of a nuclear power plant and the methods developed to combine torsional, rotational and translational responses are described. The NIB complex analyzed consists of various buildings supported on a common foundation mat and tied together from the underground foundation to the roof levels. Three independent building mathematical models were used for the three components of the earthquake with a lumped-mass method utilizing direct integration of the coupled equations of motion. The input ground acceleration time histories were based on three 20 s long statistically independent records whose mormalized response spectra enveloped those of Regulatory Guide 1.60. A linear stochastic model was used to generate these records which simulated strong motion earthquakes. Due to site characteristics, the soil material properties were calculated considering different ranges of soil moduli below and above the foundation

  15. Exergy analysis of a combined heat and power plant with integrated lignocellulosic ethanol production

    DEFF Research Database (Denmark)

    Lythcke-Jørgensen, Christoffer Ernst; Haglind, Fredrik; Clausen, Lasse Røngaard

    2014-01-01

    production. An exergy analysis is carried out for a modelled polygeneration system in which lignocellulosic ethanol production based on hydrothermal pretreatment is integrated in an existing combined heat and power (CHP) plant. The ethanol facility is driven by steam extracted from the CHP unit when feasible...... district heating production in the ethanol facility. The results suggest that the efficiency of integrating lignocellulosic ethanol production in CHP plants is highly dependent on operation, and it is therefore suggested that the expected operation pattern of such polygeneration system is taken......Lignocellulosic ethanol production is often assumed integrated in polygeneration systems because of its energy intensive nature. The objective of this study is to investigate potential irreversibilities from such integration, and what impact it has on the efficiency of the integrated ethanol...

  16. Preliminary Analysis of Aircraft Loss of Control Accidents: Worst Case Precursor Combinations and Temporal Sequencing

    Science.gov (United States)

    Belcastro, Christine M.; Groff, Loren; Newman, Richard L.; Foster, John V.; Crider, Dennis H.; Klyde, David H.; Huston, A. McCall

    2014-01-01

    Aircraft loss of control (LOC) is a leading cause of fatal accidents across all transport airplane and operational classes, and can result from a wide spectrum of hazards, often occurring in combination. Technologies developed for LOC prevention and recovery must therefore be effective under a wide variety of conditions and uncertainties, including multiple hazards, and their validation must provide a means of assessing system effectiveness and coverage of these hazards. This requires the definition of a comprehensive set of LOC test scenarios based on accident and incident data as well as future risks. This paper defines a comprehensive set of accidents and incidents over a recent 15 year period, and presents preliminary analysis results to identify worst-case combinations of causal and contributing factors (i.e., accident precursors) and how they sequence in time. Such analyses can provide insight in developing effective solutions for LOC, and form the basis for developing test scenarios that can be used in evaluating them. Preliminary findings based on the results of this paper indicate that system failures or malfunctions, crew actions or inactions, vehicle impairment conditions, and vehicle upsets contributed the most to accidents and fatalities, followed by inclement weather or atmospheric disturbances and poor visibility. Follow-on research will include finalizing the analysis through a team consensus process, defining future risks, and developing a comprehensive set of test scenarios with correlation to the accidents, incidents, and future risks. Since enhanced engineering simulations are required for batch and piloted evaluations under realistic LOC precursor conditions, these test scenarios can also serve as a high-level requirement for defining the engineering simulation enhancements needed for generating them.

  17. A combined analysis of genome-wide expression profiling of bipolar disorder in human prefrontal cortex.

    Science.gov (United States)

    Wang, Jinglu; Qu, Susu; Wang, Weixiao; Guo, Liyuan; Zhang, Kunlin; Chang, Suhua; Wang, Jing

    2016-11-01

    Numbers of gene expression profiling studies of bipolar disorder have been published. Besides different array chips and tissues, variety of the data processes in different cohorts aggravated the inconsistency of results of these genome-wide gene expression profiling studies. By searching the gene expression databases, we obtained six data sets for prefrontal cortex (PFC) of bipolar disorder with raw data and combinable platforms. We used standardized pre-processing and quality control procedures to analyze each data set separately and then combined them into a large gene expression matrix with 101 bipolar disorder subjects and 106 controls. A standard linear mixed-effects model was used to calculate the differentially expressed genes (DEGs). Multiple levels of sensitivity analyses and cross validation with genetic data were conducted. Functional and network analyses were carried out on basis of the DEGs. In the result, we identified 198 unique differentially expressed genes in the PFC of bipolar disorder and control. Among them, 115 DEGs were robust to at least three leave-one-out tests or different pre-processing methods; 51 DEGs were validated with genetic association signals. Pathway enrichment analysis showed these DEGs were related with regulation of neurological system, cell death and apoptosis, and several basic binding processes. Protein-protein interaction network further identified one key hub gene. We have contributed the most comprehensive integrated analysis of bipolar disorder expression profiling studies in PFC to date. The DEGs, especially those with multiple validations, may denote a common signature of bipolar disorder and contribute to the pathogenesis of disease. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Combined analysis of neutron and photon flux measurements for the Jules Horowitz reactor core mapping

    Energy Technology Data Exchange (ETDEWEB)

    Fourmentel, D.; Villard, J. F.; Lyoussi, A. [DEN Reactor Studies Dept., French Nuclear Energy and Alternative Energies Commission, CEA Cadarache, 13108 Saint Paul-Lez-Durance (France); Reynard-Carette, C. [Laboratoire Chimie Provence LCP UMR 6264, Univ. of Provence, Centre St. Jerome, 13397 Marseille Cedex 20 (France); Bignan, G.; Chauvin, J. P.; Gonnier, C.; Guimbal, P.; Malo, J. Y. [DEN Reactor Studies Dept., French Nuclear Energy and Alternative Energies Commission, CEA Cadarache, 13108 Saint Paul-Lez-Durance (France); Carette, M.; Janulyte, A.; Merroun, O.; Brun, J.; Zerega, Y.; Andre, J. [Laboratoire Chimie Provence LCP UMR 6264, Univ. of Provence, Centre St. Jerome, 13397 Marseille Cedex 20 (France)

    2011-07-01

    We study the combined analysis of nuclear measurements to improve the knowledge of the irradiation conditions in the experimental locations of the future Jules Horowitz Reactor (JHR). The goal of the present work is to measure more accurately neutron flux, photon flux and nuclear heating in the reactor. In a Material Testing Reactor (MTR), nuclear heating is a crucial parameter to design the experimental devices to be irradiated in harsh nuclear conditions. This parameter drives the temperature of the devices and of the samples. The numerical codes can predict this parameter but in-situ measurements are necessary to reach the expected accuracy. For this reason, one objective of the IN-CORE program [1] is to study the combined measurements of neutron and photon flux and their cross advanced interpretation. It should be reminded that both neutron and photon sensors are not totally selective as their signals are due to neutron and photon interactions. We intend to measure the neutron flux by three different kinds of sensors (Uranium Fission chamber, Plutonium Fission chamber and Self Powered Neutron Detector), the photon flux by two different sensors (Ionization chamber and Self Powered Gamma Detector) and the nuclear heating by two different ones (Differential calorimeter and Gamma Thermometer). For the same parameter, we expect that the use of different kinds of sensors will allow a better estimation of the aimed parameter by mixing different spectrum responses and different neutron and gamma contributions. An experimental test called CARMEN-1 is scheduled in OSIRIS reactor (CEA Saclay - France) at the end of 2011, with the goal to map irradiation locations in the reactor reflector to get a first validation of the analysis model. This article focuses on the sensor selection for CARMEN-1 experiment and to the way to link neutron and photon flux measurements in view to reduce their uncertainties but also to better assess the neutron and photon contributions to nuclear

  19. Combined analysis of neutron and photon flux measurements for the Jules Horowitz reactor core mapping

    International Nuclear Information System (INIS)

    Fourmentel, D.; Villard, J. F.; Lyoussi, A.; Reynard-Carette, C.; Bignan, G.; Chauvin, J. P.; Gonnier, C.; Guimbal, P.; Malo, J. Y.; Carette, M.; Janulyte, A.; Merroun, O.; Brun, J.; Zerega, Y.; Andre, J.

    2011-01-01

    We study the combined analysis of nuclear measurements to improve the knowledge of the irradiation conditions in the experimental locations of the future Jules Horowitz Reactor (JHR). The goal of the present work is to measure more accurately neutron flux, photon flux and nuclear heating in the reactor. In a Material Testing Reactor (MTR), nuclear heating is a crucial parameter to design the experimental devices to be irradiated in harsh nuclear conditions. This parameter drives the temperature of the devices and of the samples. The numerical codes can predict this parameter but in-situ measurements are necessary to reach the expected accuracy. For this reason, one objective of the IN-CORE program [1] is to study the combined measurements of neutron and photon flux and their cross advanced interpretation. It should be reminded that both neutron and photon sensors are not totally selective as their signals are due to neutron and photon interactions. We intend to measure the neutron flux by three different kinds of sensors (Uranium Fission chamber, Plutonium Fission chamber and Self Powered Neutron Detector), the photon flux by two different sensors (Ionization chamber and Self Powered Gamma Detector) and the nuclear heating by two different ones (Differential calorimeter and Gamma Thermometer). For the same parameter, we expect that the use of different kinds of sensors will allow a better estimation of the aimed parameter by mixing different spectrum responses and different neutron and gamma contributions. An experimental test called CARMEN-1 is scheduled in OSIRIS reactor (CEA Saclay - France) at the end of 2011, with the goal to map irradiation locations in the reactor reflector to get a first validation of the analysis model. This article focuses on the sensor selection for CARMEN-1 experiment and to the way to link neutron and photon flux measurements in view to reduce their uncertainties but also to better assess the neutron and photon contributions to nuclear

  20. Exergy analysis of a combined heat and power plant with integrated lignocellulosic ethanol production

    International Nuclear Information System (INIS)

    Lythcke-Jørgensen, Christoffer; Haglind, Fredrik; Clausen, Lasse R.

    2014-01-01

    Highlights: • We model a system where lignocellulosic ethanol production is integrated with a combined heat and power (CHP) plant. • We conduct an exergy analysis for the ethanol production in six different system operation points. • Integrated operation, district heating (DH) production and low CHP loads all increase the exergy efficiency. • Separate operation has the largest negative impact on the exergy efficiency. • Operation is found to have a significant impact on the exergy efficiency of the ethanol production. - Abstract: Lignocellulosic ethanol production is often assumed integrated in polygeneration systems because of its energy intensive nature. The objective of this study is to investigate potential irreversibilities from such integration, and what impact it has on the efficiency of the integrated ethanol production. An exergy analysis is carried out for a modelled polygeneration system in which lignocellulosic ethanol production based on hydrothermal pretreatment is integrated in an existing combined heat and power (CHP) plant. The ethanol facility is driven by steam extracted from the CHP unit when feasible, and a gas boiler is used as back-up when integration is not possible. The system was evaluated according to six operation points that alternate on the following three different operation parameters: Load in the CHP unit, integrated versus separate operation, and inclusion of district heating production in the ethanol facility. The calculated standard exergy efficiency of the ethanol facility varied from 0.564 to 0.855, of which the highest was obtained for integrated operation at reduced CHP load and full district heating production in the ethanol facility, and the lowest for separate operation with zero district heating production in the ethanol facility. The results suggest that the efficiency of integrating lignocellulosic ethanol production in CHP plants is highly dependent on operation, and it is therefore suggested that the

  1. Analysis of Nordic educational projects designed to meet challenges in society

    DEFF Research Database (Denmark)

    Liveng, Anne; Manninen, Jyri; Àrnason, Hróbjartur

    , process or structure identified in the successful projects: 1.Networking: Planning, implementation and development of the programme is based on networking of various - and even unexpected - organizations and players/participants. 2.Process evaluation: Continuous project development, documentation...... and analysis of results is inte-grated in the project, using Process Evaluation or Action Research 3.Flexibility: Programme offers flexible access and participation, individualized content or individualized study methods (ICT) 4.Focus on needs: A programme focuses on authentic regional, sectorial or individual...... learning providers, trade unions and other agencies supporting human development to create learning inter-ventions to address specific crisis, challenges or changes. In view of recent crises experienced by the Nordic countries The Education and Training Service Centre in Ice-land (www.frae.is) proposed...

  2. After Action Report - CUP-2 Comparative Sample Analysis Meeting - Kazakhstan September 2016

    Energy Technology Data Exchange (ETDEWEB)

    Kips, Ruth [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Lindvall, Rachel [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Eppich, Gary [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Oujo, Kaitlin [National Nuclear Security Administration (NNSA), Washington, DC (United States); Geist, William [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-09-01

    Representatives from the U.S. Department of Energy’s Office of Nuclear Smuggling Detection and Deterrence (NSDD) visited the Kazakhstan Institute of Nuclear Physics (INP) to discuss the results and conclusions of a joint sample analysis (CUP-2 uranium ore concentrate) between LLNL, INP and the Japan Atomic Energy Agency (JAEA) (Fig. 1). The U.S. delegation also met with the newly-appointed Director-General of the INP (S. Sakhiyev) who expressed his continued support for this collaboration. On the last day of the visit, the delegation toured the new medical isotope production facilities (which is expected to begin operation in a few months), as well as INP’s Nuclear Security Training Center (co-funded by DOE, the Defense Threat Reduction Initiative (DTRA) and the Kazakhstan government). Construction of the Nuclear Security Training Center is expected to be completed by the end of 2016.

  3. STAFF MEETING

    CERN Document Server

    2003-01-01

    I should like to invite all members of the CERN Personnel to a meeting on Wednesday 25th June 2003 at 11.00 hrs - Auditorium, bldg. 500 to give a report on the outcome of the June Meetings of Council and its Committees. Closed-circuit transmission of the meeting will be available in the AB Auditorium (Prévessin), the AB Auditorium (Meyrin - bldg. 6), the IT Auditorium (bldg. 31) and the AT Auditorium (bldg. 30). Luciano Maiani Director General

  4. The pollution characteristics of PM2.5 and correlation analysis with meteorological parameters in Xinxiang during the Shanghai Cooperation Organization Prime Ministers' Meeting.

    Science.gov (United States)

    Feng, Jinglan; Yu, Hao; Mi, Kai; Su, Xianfa; Chen, Yunqi; Sun, Jian-Hui; Li, Qilu

    2018-06-01

    The pollution characteristics of PM 2.5 and correlation analysis with meteorological parameters in Xinxiang during the Shanghai Cooperation Organization Prime Ministers' Meeting were investigated. During the whole meeting, nine PM 2.5 samples were collected at a suburban site of Xinxiang, and the average concentration of PM 2.5 was 122.28 μg m -3 . NO 3 - , NH 4 + , SO 4 2- accounted for 56.8% of the total water-soluble ions. In addition, with an exception of Cl - , all of water-soluble ions decreased during the meeting. Total concentrations of crustal elements ranged from 6.53 to 185.86 μg m -3 , with an average concentration of 52.51 μg m -3 , which accounted for 82.5% of total elements. The concentrations of organic carbon and elemental carbon were 7.71 and 1.52 μg m -3 , respectively, lower than those before and after the meeting. It is indicated that during the meeting, limiting motor vehicles is to reduce exhaust emissions, delay heating is to reduce the fossil fuel combustion, and other measures are to reduce the concentration of PM 2.5 . The directly dispersing by mixing layer height increase and the indirectly reducing the formation of secondary aerosol by low relative humidity, and these are the only two key removing mechanisms of PM 2.5 in Xinxiang during the meeting.

  5. Exergetic Analysis of a Novel Solar Cooling System for Combined Cycle Power Plants

    Directory of Open Access Journals (Sweden)

    Francesco Calise

    2016-09-01

    Full Text Available This paper presents a detailed exergetic analysis of a novel high-temperature Solar Assisted Combined Cycle (SACC power plant. The system includes a solar field consisting of innovative high-temperature flat plate evacuated solar thermal collectors, a double stage LiBr-H2O absorption chiller, pumps, heat exchangers, storage tanks, mixers, diverters, controllers and a simple single-pressure Combined Cycle (CC power plant. Here, a high temperature solar cooling system is coupled with a conventional combined cycle, in order to pre-cool gas turbine inlet air in order to enhance system efficiency and electrical capacity. In this paper, the system is analyzed from an exergetic point of view, on the basis of an energy-economic model presented in a recent work, where the obtained main results show that SACC exhibits a higher electrical production and efficiency with respect to the conventional CC. The system performance is evaluated by a dynamic simulation, where detailed simulation models are implemented for all the components included in the system. In addition, for all the components and for the system as whole, energy and exergy balances are implemented in order to calculate the magnitude of the irreversibilities within the system. In fact, exergy analysis is used in order to assess: exergy destructions and exergetic efficiencies. Such parameters are used in order to evaluate the magnitude of the irreversibilities in the system and to identify the sources of such irreversibilities. Exergetic efficiencies and exergy destructions are dynamically calculated for the 1-year operation of the system. Similarly, exergetic results are also integrated on weekly and yearly bases in order to evaluate the corresponding irreversibilities. The results showed that the components of the Joule cycle (combustor, turbine and compressor are the major sources of irreversibilities. System overall exergetic efficiency was around 48%. Average weekly solar collector

  6. Detection of cardiac wall motion defects with combined amplitude/phase analysis

    International Nuclear Information System (INIS)

    Bacharach, S.L.; Green, M.V.; Bonow, R.O.; Pace, L.; Brunetti, A.; Larson, S.M.

    1985-01-01

    Fourier phase images have been used with some success to detect and quantify left ventricular (LV) wall motion defects. In abnormal regions of the LV, wall motion asynchronies often cause the time activity curve (TAC) to be shifted in phase. Such regional shifts are detected by analysis of the distribution function of phase values over the LV. However, not all wall motion defects result in detectable regional phase abnormalities. Such abnormalities may cause a reduction in the magnitude of contraction (and hence TAC amplitude) without any appreciable change in TAC shape(and hence phase). In an attempt to improve the sensitivity of the Fourier phase method for the detection of wall motion defects the authors analyzed the distribution function of Fourier amplitude as well as phase. 26 individuals with normal cardiac function and no history of cardiac disease served as controls. The goal was to detect and quantify wall motion as compared to the consensus of 3 independent observers viewing the scintigraphic cines. 26 subjects with coronary artery disease and mild wall motion defects (22 with normal EF) were studied ate rest. They found that analysis of the skew of thew amplitude distribution function improved the sensitivity for the detection of wall motion abnormalities at rest in the group from 65% to 85% (17/26 detected by phase alone, 22/26 by combined phase and amplitude analysis) while retaining a 0 false positive rate in the normal group. The authors conclude that analysis of Fourier amplitude distribution functions can significantly increase the sensitivity of phase imaging for detection of wall motion abnormalities

  7. Combining dosimetry and toxicity: analysis of two UK phase III clinical trials

    International Nuclear Information System (INIS)

    Gulliford, Sarah L

    2014-01-01

    There are many advantages to performing a clinical trial when implementing a novel radiotherapy technique. The clinical trials framework enables the safety and efficacy of the 'experimental arm' to be tested and ensures practical support, rigorous quality control and data monitoring for participating centres. In addition to the clinical and follow-up data collected from patients within the trial, it is also possible to collect 3-D dosimetric information from the corresponding radiotherapy treatment plans. Analysing the combination of dosimetric, clinical and follow-up data enhances the understanding of the relationship between the dose delivered to both the target and normal tissue structures and reported outcomes and toxicity. Aspects of the collection, collation and analysis of data from two UK multicentre Phase III radiotherapy trials are presented here. MRC-RT01 dose-escalation prostate radiotherapy trial ISRCTN47772397 was one of the first UK multi-centre radiotherapy trials to collect 3-D dosimetric data. A number of different analysis methodologies were implemented to investigate the relationship between the dose distribution to the rectum and specific rectal toxicities. More recently data was collected from the PARSPORT trial (Parotid Sparing IMRT vs conventional head and neck radiotherapy) ISRCTN48243537. In addition to the planned analysis, dosimetric analysis was employed to investigate an unexpected finding that acute fatigue was more prevalent in the IMRT arm of the trial. It can be challenging to collect 3-D dosimetric information from multicentre radiotherapy trials. However, analysing the relationship between dosimetric and toxicity data provides invaluable information which can influence the next generation of radiotherapy techniques.

  8. AER Working Group D on VVER safety analysis minutes of the meeting in Rez, Czech Republic 18-20 May 1998

    International Nuclear Information System (INIS)

    Siltanen, P.

    1998-01-01

    AER Working Group D on VVER reactor safety analysis held its seventh meeting in Hotel Vltava in Rez near Prague during the period 18-20 May 1998. There were altogether 11 participants from 8 member organisations. The coordinator for the working group, Mr. P. Siltanen (IVO) served as chairman. In addition to the general information exchange on recent activities, the topics of the meeting included: First review of solutions to the 3-dimensional AER Dynamic Benchmark Problem No. 5 on a steam line break accident. This benchmark involves a break of the main steam header. Safety analysis of reactivity events. Recent code development work and fuel behaviour. Coolant mixing calculations and experiments related to diluted slugs. A list of participants and a list of handouts distributed at the meeting are attached to the minutes. (author)

  9. Finite element analysis of the combined fine blanking and extrusion process

    Science.gov (United States)

    Zheng, Peng-Fei

    The combined fine blanking and extrusion process is such a metal forming process that fine blanking and forward extrusion are carried out on sheet metal material at the same time. There are two typical characteristics in this process, one is the fine blanking whose deformation mechanism is different from conventional blanking; the other is the sheet metal extrusion, which is different from the conventional extrusion. Even though fine blanking has been used in industry for many years, only limited literature can be found which deals with the theoretical analysis of it. On the other hand, no publications on the theoretical analysis of the sheet metal extrusion have been found. Intensive work should be carried out to reveal the mechanism of both fine blanking process and sheet metal extrusion process, and further the combined fine blanking and extrusion process. The scope of this thesis is to study the mechanics of fine blanking, sheet metal extrusion, and combined fine blanking and extrusion process one by one with the rigid-plastic finite element method. All of above processes are typical unsteady ones, especially the fine blanking process in which extremely severe and localized deformation occurs. Therefore, commercial programs can not be used to solve these problems up till now. Owing to this reason, a rigid-plastic finite element program was developed for simulating these processes where remeshing and mesh tracing techniques as well as the golden section method were adopted according to the characteristics of these processes in this thesis. Moreover, a permissible kinematic velocity field was adopted as the initial velocity field for simulating extrusion process successfully. Results from the simulation included the distorted mesh, the field of material flow, the stress and the strain distributions at various moments of deformation. Results under different deformation conditions such as different blanking clearances, different diameters of the extrusion punch and

  10. Kennedy Space Center (KSC) Pad B Catenary Capability Analysis and Technical Exchange Meeting (TEM) Support

    Science.gov (United States)

    Wilson, Timmy R.; Kichak, Robert; Rakov, Vladimir; Kithil, Richard, Jr.; Sargent, Noel B.

    2009-01-01

    The existing lightning protection system at Pad 39B for the Space Shuttle is an outgrowth of a system that was put in place for the Apollo Program. Dr. Frank Fisher of Lightning Technologies was a key participant in the design and implementation of that system. He conveyed to the NESC team that the catenary wire provision was put in place quickly (as assurance against possible vehicle damage causing critical launch delays) rather than being implemented as a comprehensive system designed to provide a high degree of guaranteed protection. Also, the technology of lightning protection has evolved over time with considerable work being conducted by groups such as the electric utilities companies, aircraft manufacturers, universities, and others. Several accepted present-day methods for analysis of lightning protection were used by Drs. Medelius and Mata to study the expected lightning environment for the Pad 39B facility and to analyze the degree of protection against direct lightning attachment to the Space Shuttle. The specific physical configuration directly affects the vulnerability, so cases that were considered included the RSS next to and rolled back from the Space Shuttle, and the GOx Vent Arm both extended and withdrawn from the ET. Elements of the lightning protection system at Pad 39B are shown in Figure 6.0-1 and consist of an 80 foot insulating mast on top of the Fixed Support Structure (FSS), a catenary wire system that runs from the mast in a North/South direction to grounds 1000 feet away on each side of the mast, the RSS which can either be next to or away from the Space Shuttle, and a GOx vent that can either be extended or retracted from the top of the ET.

  11. An analysis of combined standard uncertainty for radiochemical measurements of environmental samples

    International Nuclear Information System (INIS)

    Berne, A.

    1996-01-01

    It is anticipated that future data acquisitions intended for use in radiological risk assessments will require the incorporation of uncertainty analysis. Often, only one aliquot of the sample is taken and a single determination is made. Under these circumstances, the total uncertainty is calculated using the open-quotes propagation of errorsclose quotes approach. However, there is no agreement in the radioanalytical community as to the exact equations to use. The Quality Assurance/Metrology Division of the Environmental Measurements Laboratory has developed a systematic process to compute uncertainties in constituent components of the analytical procedure, as well as the combined standard uncertainty (CSU). The equations for computation are presented here, with examples of their use. They have also been incorporated into a code for use in the spreadsheet application, QuattroPro trademark. Using the spreadsheet with appropriate inputs permits an analysis of the variations in the CSU as a function of several different variables. The relative importance of the open-quotes counting uncertaintyclose quotes can also be ascertained

  12. Recognizing stationary and locomotion activities using combinational of spectral analysis with statistical descriptors features

    Science.gov (United States)

    Zainudin, M. N. Shah; Sulaiman, Md Nasir; Mustapha, Norwati; Perumal, Thinagaran

    2017-10-01

    Prior knowledge in pervasive computing recently garnered a lot of attention due to its high demand in various application domains. Human activity recognition (HAR) considered as the applications that are widely explored by the expertise that provides valuable information to the human. Accelerometer sensor-based approach is utilized as devices to undergo the research in HAR since their small in size and this sensor already build-in in the various type of smartphones. However, the existence of high inter-class similarities among the class tends to degrade the recognition performance. Hence, this work presents the method for activity recognition using our proposed features from combinational of spectral analysis with statistical descriptors that able to tackle the issue of differentiating stationary and locomotion activities. The noise signal is filtered using Fourier Transform before it will be extracted using two different groups of features, spectral frequency analysis, and statistical descriptors. Extracted signal later will be classified using random forest ensemble classifier models. The recognition results show the good accuracy performance for stationary and locomotion activities based on USC HAD datasets.

  13. Bioremediation in marine ecosystems: a computational study combining ecological modelling and flux balance analysis

    Directory of Open Access Journals (Sweden)

    Marianna eTaffi

    2014-09-01

    Full Text Available The pressure to search effective bioremediation methodologies for contaminated ecosystems has led to the large-scale identification of microbial species and metabolic degradation pathways. However, minor attention has been paid to the study of bioremediation in marine food webs and to the definition of integrated strategies for reducing bioaccumulation in species. We propose a novel computational framework for analysing the multiscale effects of bioremediation at the ecosystem level, based on coupling food web bioaccumulation models and metabolic models of degrading bacteria. The combination of techniques from synthetic biology and ecological network analysis allows the specification of arbitrary scenarios of contaminant removal and the evaluation of strategies based on natural or synthetic microbial strains.In this study, we derive a bioaccumulation model of polychlorinated biphenyls (PCBs in the Adriatic food web, and we extend a metabolic reconstruction of Pseudomonas putida KT2440 (iJN746 with the aerobic pathway of PCBs degradation. We assess the effectiveness of different bioremediation scenarios in reducing PCBs concentration in species and we study indices of species centrality to measure their importance in the contaminant diffusion via feeding links.The analysis of the Adriatic sea case study suggests that our framework could represent a practical tool in the design of effective remediation strategies, providing at the same time insights into the ecological role of microbial communities within food webs.

  14. Combining pharmacophore fingerprints and PLS-discriminant analysis for virtual screening and SAR elucidation

    DEFF Research Database (Denmark)

    Askjær, Sune; Langgård, Morten

    2008-01-01

    The criterion of success for the initial stages of a ligand-based drug-discovery project is dual. First, a set of suitable lead compounds has to be identified. Second, a level of a preliminary structure-activity relationship (SAR) of the identified ligands has to be established in order to guide ...... by the protein-binding site known from X-ray complexes. The result of this analysis assists in explaining the efficiency of 2D pharmacophore fingerprints as descriptors in virtual screening....... the lead optimization toward a final drug candidate. This paper presents a combined approach to solving these two problems of ligand-based virtual screening and elucidation of SAR based on interplay between pharmacophore fingerprints and interpretation of PLS-discriminant analysis (PLS-DA) models....... The virtual screening capability of the PLS-DA method is compared to group fusion maximum similarity searching in a test using four graph-based pharmacophore fingerprints over a range of 10 diverse targets. The PLS-DA method was generally found to do better than the Smax method. The GpiDAPH3 and PCH...

  15. Combining tract- and atlas-based analysis reveals microstructural abnormalities in early Tourette syndrome children.

    Science.gov (United States)

    Wen, Hongwei; Liu, Yue; Wang, Jieqiong; Rekik, Islem; Zhang, Jishui; Zhang, Yue; Tian, Hongwei; Peng, Yun; He, Huiguang

    2016-05-01

    Tourette syndrome (TS) is a neurological disorder that causes uncontrolled repetitive motor and vocal tics in children. Examining the neural basis of TS churned out different research studies that advanced our understanding of the brain pathways involved in its development. Particularly, growing evidence points to abnormalities within the fronto-striato-thalamic pathways. In this study, we combined Tract-Based Spatial Statistics (TBSS) and Atlas-based regions of interest (ROI) analysis approach, to investigate the microstructural diffusion changes in both deep and superficial white matter (SWM) in TS children. We then characterized the altered microstructure of white matter in 27 TS children in comparison with 27 age- and gender-matched healthy controls. We found that fractional anisotropy (FA) decreases and radial diffusivity (RD) increases in deep white matter (DWM) tracts in cortico-striato-thalamo-cortical (CSTC) circuit as well as SWM. Furthermore, we found that lower FA values and higher RD values in white matter regions are correlated with more severe tics, but not tics duration. Besides, we also found both axial diffusivity and mean diffusivity increase using Atlas-based ROI analysis. Our work may suggest that microstructural diffusion changes in white matter is not only restricted to the gray matter of CSTC circuit but also affects SWM within the primary motor and somatosensory cortex, commissural and association fibers. Hum Brain Mapp 37:1903-1919, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  16. Modeling and Analysis of a Combined Stress-Vibration Fiber Bragg Grating Sensor.

    Science.gov (United States)

    Yao, Kun; Lin, Qijing; Jiang, Zhuangde; Zhao, Na; Tian, Bian; Shi, Peng; Peng, Gang-Ding

    2018-03-01

    A combined stress-vibration sensor was developed to measure stress and vibration simultaneously based on fiber Bragg grating (FBG) technology. The sensor is composed of two FBGs and a stainless steel plate with a special design. The two FBGs sense vibration and stress and the sensor can realize temperature compensation by itself. The stainless steel plate can significantly increase sensitivity of vibration measurement. Theoretical analysis and Finite Element Method (FEM) were used to analyze the sensor's working mechanism. As demonstrated with analysis, the obtained sensor has working range of 0-6000 Hz for vibration sensing and 0-100 MPa for stress sensing, respectively. The corresponding sensitivity for vibration is 0.46 pm/g and the resulted stress sensitivity is 5.94 pm/MPa, while the nonlinearity error for vibration and stress measurement is 0.77% and 1.02%, respectively. Compared to general FBGs, the vibration sensitivity of this sensor is 26.2 times higher. Therefore, the developed sensor can be used to concurrently detect vibration and stress. As this sensor has height of 1 mm and weight of 1.15 g, it is beneficial for minimization and integration.

  17. A combined method for DNA analysis and radiocarbon dating from a single sample.

    Science.gov (United States)

    Korlević, Petra; Talamo, Sahra; Meyer, Matthias

    2018-03-07

    Current protocols for ancient DNA and radiocarbon analysis of ancient bones and teeth call for multiple destructive samplings of a given specimen, thereby increasing the extent of undesirable damage to precious archaeological material. Here we present a method that makes it possible to obtain both ancient DNA sequences and radiocarbon dates from the same sample material. This is achieved by releasing DNA from the bone matrix through incubation with either EDTA or phosphate buffer prior to complete demineralization and collagen extraction utilizing the acid-base-acid-gelatinization and ultrafiltration procedure established in most radiocarbon dating laboratories. Using a set of 12 bones of different ages and preservation conditions we demonstrate that on average 89% of the DNA can be released from sample powder with minimal, or 38% without any, detectable collagen loss. We also detect no skews in radiocarbon dates compared to untreated samples. Given the different material demands for radiocarbon dating (500 mg of bone/dentine) and DNA analysis (10-100 mg), combined DNA and collagen extraction not only streamlines the sampling process but also drastically increases the amount of DNA that can be recovered from limited sample material.

  18. Reliability Analysis of Core Protection Calculator System by Combining Petri Net and Fault Tree

    International Nuclear Information System (INIS)

    Kim, Hyejin; Kim, Jonghyun

    2013-01-01

    This paper proposes an approach to analyzing the reliability of digital systems by combining Petri net (PN) and Fault tree. The Petri net allows modeling event dependencies and interaction, to represent the time sequence, and to model assumptions for dynamic events. The Petri net model can be straightforwardly transformed to fault tree using the gate. Then, the FT can be integrated into the existing PSA. This paper applies the approach to the reliability analysis of Core Protection Calculator System (CPCS). Digital technology is replacing the analog instrumentation and control (I and C) systems in both new and upgraded nuclear power plants. As digital systems are introduced to nuclear power plants, issues related with reliability analyses of these digital systems are being raised. One of these issues is that static fault tree (FT) and event tree (ET) approach cannot properly account for dynamic interactions in the digital systems, such as multiple top events, logic loops and time delay. Many methods have been proposed to solve the problems, but there is no single method that is universally accepted for the application to the current generation probabilistic safety analysis (PSA)

  19. Reliability Analysis of Core Protection Calculator System by Combining Petri Net and Fault Tree

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyejin; Kim, Jonghyun [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

    2013-10-15

    This paper proposes an approach to analyzing the reliability of digital systems by combining Petri net (PN) and Fault tree. The Petri net allows modeling event dependencies and interaction, to represent the time sequence, and to model assumptions for dynamic events. The Petri net model can be straightforwardly transformed to fault tree using the gate. Then, the FT can be integrated into the existing PSA. This paper applies the approach to the reliability analysis of Core Protection Calculator System (CPCS). Digital technology is replacing the analog instrumentation and control (I and C) systems in both new and upgraded nuclear power plants. As digital systems are introduced to nuclear power plants, issues related with reliability analyses of these digital systems are being raised. One of these issues is that static fault tree (FT) and event tree (ET) approach cannot properly account for dynamic interactions in the digital systems, such as multiple top events, logic loops and time delay. Many methods have been proposed to solve the problems, but there is no single method that is universally accepted for the application to the current generation probabilistic safety analysis (PSA)

  20. Value impact analysis utilizing PRA techniques combined with a hybrid plant model

    International Nuclear Information System (INIS)

    Edson, J.L.; Stillwell, D.W.

    1989-01-01

    A value impact analysis (VIA) has been performed by the INEL to support a NRC Regulatory Analysis for resolution of Generic Issue (GI) 29, Bolting Degradation or Failure in Nuclear Power Plants. A VIA for replacing the reactor coolant pressure boundary (RCPB) bolts of BWRs and PWRs was previously prepared by Pacific Northwest Laboratories in 1985 under instructions limiting the VIA to the potential for failure of primary pressure boundary bolting. Subsequently the INEL was requested to perform a VIA that included non primary systems and component support bolts to be compatible with the resolution of the broader issue. Because the initial list of systems and bolting applications that could be included in the VIA was very large, including them all in the VIA would likely result in analyzing some that have little if any effect on public risk. This paper discusses how PRA techniques combined with a hybrid plant model were used to determine which bolts have the potential to be significant contributors to public risk if they were to fail, and therefore were included in the VIA

  1. Relevant climate response tests for stratospheric aerosol injection: A combined ethical and scientific analysis

    Science.gov (United States)

    Lenferna, Georges Alexandre; Russotto, Rick D.; Tan, Amanda; Gardiner, Stephen M.; Ackerman, Thomas P.

    2017-06-01

    In this paper, we focus on stratospheric sulfate injection as a geoengineering scheme, and provide a combined scientific and ethical analysis of climate response tests, which are a subset of outdoor tests that would seek to impose detectable and attributable changes to climate variables on global or regional scales. We assess the current state of scientific understanding on the plausibility and scalability of climate response tests. Then, we delineate a minimal baseline against which to consider whether certain climate response tests would be relevant for a deployment scenario. Our analysis shows that some climate response tests, such as those attempting to detect changes in regional climate impacts, may not be deployable in time periods relevant to realistic geoengineering scenarios. This might pose significant challenges for justifying stratospheric sulfate aerosol injection deployment overall. We then survey some of the major ethical challenges that proposed climate response tests face. We consider what levels of confidence would be required to ethically justify approving a proposed test; whether the consequences of tests are subject to similar questions of justice, compensation, and informed consent as full-scale deployment; and whether questions of intent and hubris are morally relevant for climate response tests. We suggest further research into laboratory-based work and modeling may help to narrow the scientific uncertainties related to climate response tests, and help inform future ethical debate. However, even if such work is pursued, the ethical issues raised by proposed climate response tests are significant and manifold.

  2. A Combined Ethical and Scientific Analysis of Large-scale Tests of Solar Climate Engineering

    Science.gov (United States)

    Ackerman, T. P.

    2017-12-01

    Our research group recently published an analysis of the combined ethical and scientific issues surrounding large-scale testing of stratospheric aerosol injection (SAI; Lenferna et al., 2017, Earth's Future). We are expanding this study in two directions. The first is extending this same analysis to other geoengineering techniques, particularly marine cloud brightening (MCB). MCB has substantial differences to SAI in this context because MCB can be tested over significantly smaller areas of the planet and, following injection, has a much shorter lifetime of weeks as opposed to years for SAI. We examine issues such as the role of intent, the lesser of two evils, and the nature of consent. In addition, several groups are currently considering climate engineering governance tools such as a code of ethics and a registry. We examine how these tools might influence climate engineering research programs and, specifically, large-scale testing. The second direction of expansion is asking whether ethical and scientific issues associated with large-scale testing are so significant that they effectively preclude moving ahead with climate engineering research and testing. Some previous authors have suggested that no research should take place until these issues are resolved. We think this position is too draconian and consider a more nuanced version of this argument. We note, however, that there are serious questions regarding the ability of the scientific research community to move to the point of carrying out large-scale tests.

  3. Combination of canonical correlation analysis and empirical mode decomposition applied to denoising the labor electrohysterogram.

    Science.gov (United States)

    Hassan, Mahmoud; Boudaoud, Sofiane; Terrien, Jérémy; Karlsson, Brynjar; Marque, Catherine

    2011-09-01

    The electrohysterogram (EHG) is often corrupted by electronic and electromagnetic noise as well as movement artifacts, skeletal electromyogram, and ECGs from both mother and fetus. The interfering signals are sporadic and/or have spectra overlapping the spectra of the signals of interest rendering classical filtering ineffective. In the absence of efficient methods for denoising the monopolar EHG signal, bipolar methods are usually used. In this paper, we propose a novel combination of blind source separation using canonical correlation analysis (BSS_CCA) and empirical mode decomposition (EMD) methods to denoise monopolar EHG. We first extract the uterine bursts by using BSS_CCA then the biggest part of any residual noise is removed from the bursts by EMD. Our algorithm, called CCA_EMD, was compared with wavelet filtering and independent component analysis. We also compared CCA_EMD with the corresponding bipolar signals to demonstrate that the new method gives signals that have not been degraded by the new method. The proposed method successfully removed artifacts from the signal without altering the underlying uterine activity as observed by bipolar methods. The CCA_EMD algorithm performed considerably better than the comparison methods.

  4. A combined stochastic analysis of mean daily temperature and diurnal temperature range

    Science.gov (United States)

    Sirangelo, B.; Caloiero, T.; Coscarelli, R.; Ferrari, E.

    2018-03-01

    In this paper, a stochastic model, previously proposed for the maximum daily temperature, has been improved for the combined analysis of mean daily temperature and diurnal temperature range. In particular, the procedure applied to each variable sequentially performs the deseasonalization, by means of truncated Fourier series expansions, and the normalization of the temperature data, with the use of proper transformation functions. Then, a joint stochastic analysis of both the climatic variables has been performed by means of a FARIMA model, taking into account the stochastic dependency between the variables, namely introducing a cross-correlation between the standardized noises. The model has been applied to five daily temperature series of southern Italy. After the application of a Monte Carlo simulation procedure, the return periods of the joint behavior of the mean daily temperature and the diurnal temperature range have been evaluated. Moreover, the annual maxima of the temperature excursions in consecutive days have been analyzed for the synthetic series. The results obtained showed different behaviors probably linked to the distance from the sea and to the latitude of the station.

  5. A combined sensitivity analysis and kriging surrogate modeling for early validation of health indicators

    International Nuclear Information System (INIS)

    Lamoureux, Benjamin; Mechbal, Nazih; Massé, Jean-Rémi

    2014-01-01

    To increase the dependability of complex systems, one solution is to assess their state of health continuously through the monitoring of variables sensitive to potential degradation modes. When computed in an operating environment, these variables, known as health indicators, are subject to many uncertainties. Hence, the stochastic nature of health assessment combined with the lack of data in design stages makes it difficult to evaluate the efficiency of a health indicator before the system enters into service. This paper introduces a method for early validation of health indicators during the design stages of a system development process. This method uses physics-based modeling and uncertainties propagation to create simulated stochastic data. However, because of the large number of parameters defining the model and its computation duration, the necessary runtime for uncertainties propagation is prohibitive. Thus, kriging is used to obtain low computation time estimations of the model outputs. Moreover, sensitivity analysis techniques are performed upstream to determine the hierarchization of the model parameters and to reduce the dimension of the input space. The validation is based on three types of numerical key performance indicators corresponding to the detection, identification and prognostic processes. After having introduced and formalized the framework of uncertain systems modeling and the different performance metrics, the issues of sensitivity analysis and surrogate modeling are addressed. The method is subsequently applied to the validation of a set of health indicators for the monitoring of an aircraft engine’s pumping unit

  6. The analysis study of plutonium in the environmental sample by mass spectrum combined with isotopic dilution

    International Nuclear Information System (INIS)

    Han Jun; Fu Zhonghua; Mao Xingen; Meng Fanben

    2004-01-01

    The technology of the rhenium filament carbonization was used to increase the ionization efficiency in this paper. The plutonium in the environmental sample was analyzed by Mass Spectrum combined with isotope dilution. Analysis of the 239 Pu blank in the process: The analysis of 239 Pu from the chemical process was carried out in order to establish the influence of the 239 Pu introduced from the process. The analysis results were shown in Table 1 sample 1 was not gone through the process, sample 2 and sample 3 were gone through the process. It was clear that there was no influence of the 239 Pu from the process within the deviation. Results and Discussions: The environmental samples which were dealed with the chemical method were prepared the sample of mass spectrum, The atomic ratio of the 239 Pu and 242 Pu in the environmental samples was measured by Mass Spectrum. The atomic ratio in the tracer 242 Pu was 0.01476±0.00007.The results for nuclide content in environment were given in Table 2. The content of 239 Pu in the tracer was high, so the existing of 239 Pu in the environmental samples can be determined by the changing of the atomic ratio of 242 Pu to 239 Pu. It was clear that there was 239 Pu in the environmental samples except the cypress leaves-2 and the pine leaves-3 within the deviation, and the content of 239 Pu were given in Table 2. Conclusion: a. Plutonium was separated and purified from the impurity by the anion-exchange and the electrodeposition, it was possible to provide the eligible mass spectrum sample. b. The measurement of plutonium in the environmental samples was not influenced by the flow of the background in the experiment. c. As the technology of the rhenium carbonization was used to increase the ionization efficiency, the content of plutonium which was about 10 -13 g in the environmental sample could be quantitatively analyzed by Mass Spectrum combined with isotope dilution. (authors)

  7. A simple method for the design of tension structures combining topological mapping and nonlinear structural analysis

    Directory of Open Access Journals (Sweden)

    Jurado-Piña, R.

    2014-12-01

    Full Text Available When designing a tension structure the shape is not known at the beginning of the process. Form-finding methods allow the designer to obtain an initial shape from given boundary conditions. Several form-finding methods for tension structures are already available in the technical literature; all of them posses certain limitations and drawbacks and no single method is optimal for all problems. The engineer may select the proper combination of methods best suited to the designer’s needs. In this paper it is proposed a combined method to achieve satisfactory equilibrium configurations for fabric tension structures. The force density method (FDM implemented with topological mapping (TM is used as a search engine for the preliminary design, and a procedure that employs nonlinear structural analysis is proposed for final refinement of the initial equilibrium configuration hence allowing the use of the same analysis tool for both refinement of the solution and analysis under loading.Al diseñar una estructura tensada la forma inicial es normalmente desconocida. Los métodos de búsqueda de forma permiten al ingeniero obtener una geometría inicial dadas unas condiciones de contorno. Existen diferentes métodos de búsqueda de formas de equilibrio, pero todos tienen limitaciones y no existe uno único óptimo para cualquier tipo de problema. El ingeniero debe elegir la combinación de métodos que mejor se adapte a sus necesidades. En este artículo se propone un método combinado para generar configuraciones de equilibrio satisfactorias en estructuras tensadas. Como motor de búsqueda para el diseño preliminar se emplea el método de las densidades de fuerza (FDM implementado con mallado en topología (TM, y se propone un procedimiento basado en análisis no lineal de estructuras para el refinamiento de la configuración inicial de equilibrio, permitiéndose así el empleo de las mismas herramientas tanto para el refinamiento de la solución inicial

  8. Combined analysis of cortical (EEG) and nerve stump signals improves robotic hand control.

    Science.gov (United States)

    Tombini, Mario; Rigosa, Jacopo; Zappasodi, Filippo; Porcaro, Camillo; Citi, Luca; Carpaneto, Jacopo; Rossini, Paolo Maria; Micera, Silvestro

    2012-01-01

    Interfacing an amputee's upper-extremity stump nerves to control a robotic hand requires training of the individual and algorithms to process interactions between cortical and peripheral signals. To evaluate for the first time whether EEG-driven analysis of peripheral neural signals as an amputee practices could improve the classification of motor commands. Four thin-film longitudinal intrafascicular electrodes (tf-LIFEs-4) were implanted in the median and ulnar nerves of the stump in the distal upper arm for 4 weeks. Artificial intelligence classifiers were implemented to analyze LIFE signals recorded while the participant tried to perform 3 different hand and finger movements as pictures representing these tasks were randomly presented on a screen. In the final week, the participant was trained to perform the same movements with a robotic hand prosthesis through modulation of tf-LIFE-4 signals. To improve the classification performance, an event-related desynchronization/synchronization (ERD/ERS) procedure was applied to EEG data to identify the exact timing of each motor command. Real-time control of neural (motor) output was achieved by the participant. By focusing electroneurographic (ENG) signal analysis in an EEG-driven time window, movement classification performance improved. After training, the participant regained normal modulation of background rhythms for movement preparation (α/β band desynchronization) in the sensorimotor area contralateral to the missing limb. Moreover, coherence analysis found a restored α band synchronization of Rolandic area with frontal and parietal ipsilateral regions, similar to that observed in the opposite hemisphere for movement of the intact hand. Of note, phantom limb pain (PLP) resolved for several months. Combining information from both cortical (EEG) and stump nerve (ENG) signals improved the classification performance compared with tf-LIFE signals processing alone; training led to cortical reorganization and

  9. ATM and p53 combined analysis predicts survival in glioblastoma multiforme patients: A clinicopathologic study.

    Science.gov (United States)

    Romano, Francesco Jacopo; Guadagno, Elia; Solari, Domenico; Borrelli, Giorgio; Pignatiello, Sara; Cappabianca, Paolo; Del Basso De Caro, Marialaura

    2018-06-01

    Glioblastoma is one of the most malignant cancers, with a distinguishing dismal prognosis: surgery followed by chemo- and radiotherapy represents the current standard of care, and chemo- and radioresistance underlie disease recurrence and short overall survival of patients suffering from this malignancy. ATM is a kinase activated by autophosphorylation upon DNA doublestrand breaks arising from errors during replication, byproducts of metabolism, chemotherapy or ionizing radiations; TP53 is one of the most popular tumor suppressor, with a preeminent role in DNA damage response and repair. To study the effects of the immunohistochemical expression of p-ATM and p53 in glioblastoma patients, 21 cases were retrospectively examined. In normal brain tissue, p-ATM was expressed only in neurons; conversely, in tumors cells, the protein showed a variable cytoplasmic expression (score: +,++,+++), with being completely undetectable in three cases. Statistical analysis revealed that high p-ATM score (++/+++) strongly correlated to shorter survival (P = 0.022). No difference in overall survival was registered between p53 normally expressed (NE) and overexpressed (OE) glioblastoma patients (P = 0.669). Survival analysis performed on the results from combined assessment of the two proteins showed that patients with NE p53 /low pATM score had longer overall survival than the NE p53/ high pATM score counterpart. Cox-regression analysis confirmed this finding (HR = 0.025; CI 95% = 0.002-0.284; P = 0.003). Our study outlined the immunohistochemical expression of p-ATM/p53 in glioblastomas and provided data on their possible prognostic/predictive of response role. A "non-oncogene addiction" to ATM for NEp53 glioblastoma could be postulated, strengthening the rationale for development of ATM inhibiting drugs. © 2018 Wiley Periodicals, Inc.

  10. Combining biophysical methods for the analysis of protein complex stoichiometry and affinity in SEDPHAT

    International Nuclear Information System (INIS)

    Zhao, Huaying; Schuck, Peter

    2015-01-01

    Global multi-method analysis for protein interactions (GMMA) can increase the precision and complexity of binding studies for the determination of the stoichiometry, affinity and cooperativity of multi-site interactions. The principles and recent developments of biophysical solution methods implemented for GMMA in the software SEDPHAT are reviewed, their complementarity in GMMA is described and a new GMMA simulation tool set in SEDPHAT is presented. Reversible macromolecular interactions are ubiquitous in signal transduction pathways, often forming dynamic multi-protein complexes with three or more components. Multivalent binding and cooperativity in these complexes are often key motifs of their biological mechanisms. Traditional solution biophysical techniques for characterizing the binding and cooperativity are very limited in the number of states that can be resolved. A global multi-method analysis (GMMA) approach has recently been introduced that can leverage the strengths and the different observables of different techniques to improve the accuracy of the resulting binding parameters and to facilitate the study of multi-component systems and multi-site interactions. Here, GMMA is described in the software SEDPHAT for the analysis of data from isothermal titration calorimetry, surface plasmon resonance or other biosensing, analytical ultracentrifugation, fluorescence anisotropy and various other spectroscopic and thermodynamic techniques. The basic principles of these techniques are reviewed and recent advances in view of their particular strengths in the context of GMMA are described. Furthermore, a new feature in SEDPHAT is introduced for the simulation of multi-method data. In combination with specific statistical tools for GMMA in SEDPHAT, simulations can be a valuable step in the experimental design

  11. A Combined Linkage and Exome Sequencing Analysis for Electrocardiogram Parameters in the Erasmus Rucphen Family Study.

    Science.gov (United States)

    Silva, Claudia T; Zorkoltseva, Irina V; Amin, Najaf; Demirkan, Ayşe; van Leeuwen, Elisabeth M; Kors, Jan A; van den Berg, Marten; Stricker, Bruno H; Uitterlinden, André G; Kirichenko, Anatoly V; Witteman, Jacqueline C M; Willemsen, Rob; Oostra, Ben A; Axenovich, Tatiana I; van Duijn, Cornelia M; Isaacs, Aaron

    2016-01-01

    Electrocardiogram (ECG) measurements play a key role in the diagnosis and prediction of cardiac arrhythmias and sudden cardiac death. ECG parameters, such as the PR, QRS, and QT intervals, are known to be heritable and genome-wide association studies of these phenotypes have been successful in identifying common variants; however, a large proportion of the genetic variability of these traits remains to be elucidated. The aim of this study was to discover loci potentially harboring rare variants utilizing variance component linkage analysis in 1547 individuals from a large family-based study, the Erasmus Rucphen Family Study (ERF). Linked regions were further explored using exome sequencing. Five suggestive linkage peaks were identified: two for QT interval (1q24, LOD = 2.63; 2q34, LOD = 2.05), one for QRS interval (1p35, LOD = 2.52) and two for PR interval (9p22, LOD = 2.20; 14q11, LOD = 2.29). Fine-mapping using exome sequence data identified a C > G missense variant (c.713C > G, p.Ser238Cys) in the FCRL2 gene associated with QT (rs74608430; P = 2.8 × 10 -4 , minor allele frequency = 0.019). Heritability analysis demonstrated that the SNP explained 2.42% of the trait's genetic variability in ERF ( P = 0.02). Pathway analysis suggested that the gene is involved in cytosolic Ca 2+ levels ( P = 3.3 × 10 -3 ) and AMPK stimulated fatty acid oxidation in muscle ( P = 4.1 × 10 -3 ). Look-ups in bioinformatics resources showed that expression of FCRL2 is associated with ARHGAP24 and SETBP1 expression. This finding was not replicated in the Rotterdam study. Combining the bioinformatics information with the association and linkage analyses, FCRL2 emerges as a strong candidate gene for QT interval.

  12. A combined linkage and exome sequencing analysis for electrocardiogram parameters in the Erasmus Rucphen Family study

    Directory of Open Access Journals (Sweden)

    Claudia Tamar Silva

    2016-11-01

    Full Text Available Electrocardiogram (ECG measurements play a key role in the diagnosis and prediction of cardiac arrhythmias and sudden cardiac death. ECG parameters, such as the PR, QRS, and QT intervals, are known to be heritable and genome-wide association studies (GWAS of these phenotypes have been successful in identifying common variants; however, a large proportion of the genetic variability of these traits remains to be elucidated. The aim of this study was to discover loci potentially harboring rare variants utilizing variance component linkage analysis in 1547 individuals from a large family-based study, the Erasmus Rucphen Family Study (ERF. Linked regions were further explored using exome sequencing. Five suggestive linkage peaks were identified: two for QT interval (1q24, LOD = 2.63; 2q34, LOD = 2.05, one for QRS interval (1p35, LOD = 2.52 and two for PR interval (9p22, LOD = 2.20; 14q11, LOD = 2.29. Fine-mapping using exome sequence data identified a C > G missense variant (c.713C>G, p.Ser238Cys in the FCRL2 gene associated with QT (rs74608430; P = 2.8 ×10-4, minor allele frequency = 0.019. Heritability analysis demonstrated that the SNP explained 2.42% of the trait’s genetic variability in ERF (P = 0.02. Pathway analysis suggested that the gene is involved in cytosolic Ca2+ levels (P = 3.3 × 10-3 and AMPK stimulated fatty acid oxidation in muscle (P = 4.1 ×10-3. Look-ups in bioinformatics resources showed that expression of FCRL2 is associated with ARHGAP24 and SETBP1 expression. This finding was not replicated in the Rotterdam study. Combining the bioinformatics information with the association and linkage analyses, FCRL2 emerges as a strong candidate gene for QT interval.

  13. Logic Meeting

    CERN Document Server

    Tugué, Tosiyuki; Slaman, Theodore

    1989-01-01

    These proceedings include the papers presented at the logic meeting held at the Research Institute for Mathematical Sciences, Kyoto University, in the summer of 1987. The meeting mainly covered the current research in various areas of mathematical logic and its applications in Japan. Several lectures were also presented by logicians from other countries, who visited Japan in the summer of 1987.

  14. Report on the combined meeting of the core confinement and internal transport barrier expert group, confinement database and modeling expert group and edge pedestal expert group, 12-16 April 1999, Garching

    International Nuclear Information System (INIS)

    Janeschitz, G.; Connor, J.W.; Cordey, G.; Kardaun, O.; Mukhovatov, V.; Stambaugh, R.; Ryter, F.; Wakatani, M.

    1999-01-01

    This contribution to the ITER EDA Newsletter reports on the combined meeting of the core confinement and internal transport barrier expert group, confinement database and modeling expert group and edge pedestal expert group in Garching, Germany. This is the first workshop of its kind after the re-organisation of the expert groups. The new scheme of the meetings, namely to permit more interaction between groups by arranging them at the same time and location turned out to be very successful. The main issues discussed were for the Confinement Database: merging of edge pedestal and confinement data, improvement of the density- and magnetic shape parameters, addition of new dedicated threshold data, the effect of different divertors in JET; for the H-Mode Power Threshold Database: assembly of a new version of the database with about 650 time points from 10 tokamaks; for the 1-D Modelling Workshop: management of the database after the re-organisation of the Joint Central Team an ongoing efforts in plasma transport modelling; for the newly formed pedestal group: issues of the H-mode shear layer at the plasma edge. There was also an executive summary given of a recent USA workshop on internal transport barriers and regimes with weak or negative magnetic shear

  15. The Immersive Virtual Reality Experience: A Typology of Users Revealed Through Multiple Correspondence Analysis Combined with Cluster Analysis Technique.

    Science.gov (United States)

    Rosa, Pedro J; Morais, Diogo; Gamito, Pedro; Oliveira, Jorge; Saraiva, Tomaz

    2016-03-01

    Immersive virtual reality is thought to be advantageous by leading to higher levels of presence. However, and despite users getting actively involved in immersive three-dimensional virtual environments that incorporate sound and motion, there are individual factors, such as age, video game knowledge, and the predisposition to immersion, that may be associated with the quality of virtual reality experience. Moreover, one particular concern for users engaged in immersive virtual reality environments (VREs) is the possibility of side effects, such as cybersickness. The literature suggests that at least 60% of virtual reality users report having felt symptoms of cybersickness, which reduces the quality of the virtual reality experience. The aim of this study was thus to profile the right user to be involved in a VRE through head-mounted display. To examine which user characteristics are associated with the most effective virtual reality experience (lower cybersickness), a multiple correspondence analysis combined with cluster analysis technique was performed. Results revealed three distinct profiles, showing that the PC gamer profile is more associated with higher levels of virtual reality effectiveness, that is, higher predisposition to be immersed and reduced cybersickness symptoms in the VRE than console gamer and nongamer. These findings can be a useful orientation in clinical practice and future research as they help identify which users are more predisposed to benefit from immersive VREs.

  16. Investigation of Lab Fire Prevention Management System of Combining Root Cause Analysis and Analytic Hierarchy Process with Event Tree Analysis

    Directory of Open Access Journals (Sweden)

    Cheng-Chan Shih

    2016-01-01

    Full Text Available This paper proposed a new approach, combining root cause analysis (RCA, analytic hierarchy process (AHP, and event tree analysis (ETA in a loop to systematically evaluate various laboratory safety prevention strategies. First, 139 fire accidents were reviewed to identify the root causes and draw out prevention strategies. Most fires were caused due to runaway reactions, operation error and equipment failure, and flammable material release. These mostly occurred in working places of no prompt fire protection. We also used AHP to evaluate the priority of these strategies and found that chemical fire prevention strategy is the most important control element, and strengthening maintenance and safety inspection intensity is the most important action. Also together with our surveys results, we proposed that equipment design is also critical for fire prevention. Therefore a technical improvement was propounded: installing fire detector, automatic sprinkler, and manual extinguisher in the lab hood as proactive fire protections. ETA was then used as a tool to evaluate laboratory fire risks. The results indicated that the total risk of a fire occurring decreases from 0.0351 to 0.0042 without/with equipment taking actions. Establishing such system can make Environment, Health and Safety (EH&S office not only analyze and prioritize fire prevention policies more practically, but also demonstrate how effective protective equipment improvement can achieve and the probabilities of the initiating event developing into a serious accident or controlled by the existing safety system.

  17. Combining Spot Sign and Intracerebral Hemorrhage Score to Estimate Functional Outcome: Analysis From the PREDICT Cohort.

    Science.gov (United States)

    Schneider, Hauke; Huynh, Thien J; Demchuk, Andrew M; Dowlatshahi, Dar; Rodriguez-Luna, David; Silva, Yolanda; Aviv, Richard; Dzialowski, Imanuel

    2018-06-01

    The intracerebral hemorrhage (ICH) score is the most commonly used grading scale for stratifying functional outcome in patients with acute ICH. We sought to determine whether a combination of the ICH score and the computed tomographic angiography spot sign may improve outcome prediction in the cohort of a prospective multicenter hemorrhage trial. Prospectively collected data from 241 patients from the observational PREDICT study (Prediction of Hematoma Growth and Outcome in Patients With Intracerebral Hemorrhage Using the CT-Angiography Spot Sign) were analyzed. Functional outcome at 3 months was dichotomized using the modified Rankin Scale (0-3 versus 4-6). Performance of (1) the ICH score and (2) the spot sign ICH score-a scoring scale combining ICH score and spot sign number-was tested. Multivariable analysis demonstrated that ICH score (odds ratio, 3.2; 95% confidence interval, 2.2-4.8) and spot sign number (n=1: odds ratio, 2.7; 95% confidence interval, 1.1-7.4; n>1: odds ratio, 3.8; 95% confidence interval, 1.2-17.1) were independently predictive of functional outcome at 3 months with similar odds ratios. Prediction of functional outcome was not significantly different using the spot sign ICH score compared with the ICH score alone (spot sign ICH score area under curve versus ICH score area under curve: P =0.14). In the PREDICT cohort, a prognostic score adding the computed tomographic angiography-based spot sign to the established ICH score did not improve functional outcome prediction compared with the ICH score. © 2018 American Heart Association, Inc.

  18. A novel ergodic capacity analysis of diversity combining and multihop transmission systems over generalized composite fading channels

    KAUST Repository

    Yilmaz, Ferkan

    2012-06-01

    Ergodic capacity is an important performance measure associated with reliable communication at the highest rate at which information can be sent over the channel with a negligible probability of error. In the shadow of this definition, diversity receivers (such as selection combining, equal-gain combining and maximal-ratio combining) and transmission techniques (such as cascaded fading channels, amplify-and-forward multihop transmission) are deployed in mitigating various performance impairing effects such as fading and shadowing in digital radio communication links. However, the exact analysis of ergodic capacity is in general not always possible for all of these forms of diversity receivers and transmission techniques over generalized composite fading environments due to it\\'s mathematical intractability. In the literature, published papers concerning the exact analysis of ergodic capacity have been therefore scarce (i.e., only [1] and [2]) when compared to those concerning the exact analysis of average symbol error probability. In addition, they are essentially targeting to the ergodic capacity of the maximal ratio combining diversity receivers and are not readily applicable to the capacity analysis of the other diversity combiners / transmission techniques. In this paper, we propose a novel moment generating function-based approach for the exact ergodic capacity analysis of both diversity receivers and transmission techniques over generalized composite fading environments. As such, we demonstrate how to simultaneously treat the ergodic capacity analysis of all forms of both diversity receivers and multihop transmission techniques. © 2012 IEEE.

  19. Elemental analysis by surface-enhanced Laser-Induced Breakdown Spectroscopy combined with liquid–liquid microextraction

    International Nuclear Information System (INIS)

    Aguirre, M.A.; Legnaioli, S.; Almodóvar, F.; Hidalgo, M.; Palleschi, V.; Canals, A.

    2013-01-01

    In this work, the possibility of using Laser-Induced Breakdown Spectrometry (LIBS) combined with liquid–liquid microextraction techniques is evaluated as a simple and fast method for trace elemental analysis. Two different strategies for LIBS analysis of manganese contained in microdroplets of extraction solvent (Triton X-114) are studied: (i) analysis by direct laser irradiation of microdroplets; and (ii) analysis by laser irradiation of microdroplets dried on metallic substrates (surface-enhanced LIBS — SENLIBS). Experiments were carried out using synthetic samples with different concentrations of manganese in a 10% w/w Triton X-114 matrix. The analysis by direct laser irradiation of microdroplets showed low precision, sensitivity and poor linearity across the concentration range evaluated (R 2 −1 of Mn. - Highlights: ► LIBS combined with microextraction procedures for trace analysis is proposed. ► The proposed combination depends on LIBS ability to analyze sample microvolumes. ► A surface-enhanced LIBS methodology for microdroplet analysis was evaluated. ► Results indicate this combination to be promising for trace analysis in liquids

  20. Prediction of quality attributes of chicken breast fillets by using Vis/NIR spectroscopy combined with factor analysis method

    Science.gov (United States)

    Visible/near-infrared (Vis/NIR) spectroscopy with wavelength range between 400 and 2500 nm combined with factor analysis method was tested to predict quality attributes of chicken breast fillets. Quality attributes, including color (L*, a*, b*), pH, and drip loss were analyzed using factor analysis ...

  1. Summary Report of Consultants' Meeting on Accuracy of Experimental and Theoretical Nuclear Cross-Section Data for Ion Beam Analysis and Benchmarking

    International Nuclear Information System (INIS)

    Abriola, Daniel; Dimitriou, Paraskevi; Gurbich, Alexander F.

    2013-11-01

    A summary is given of a Consultants' Meeting assembled to assess the accuracy of experimental and theoretical nuclear cross-section data for Ion Beam Analysis and the role of benchmarking experiments. The participants discussed the different approaches to assigning uncertainties to evaluated data, and presented results of benchmark experiments performed in their laboratories. They concluded that priority should be given to the validation of cross- section data by benchmark experiments, and recommended that an experts meeting be held to prepare the guidelines, methodology and work program of a future coordinated project on benchmarking.

  2. Differential algebraic method for arbitrary order curvilinear-axis combined geometric-chromatic aberration analysis

    International Nuclear Information System (INIS)

    Cheng Min; Tang Tiantong; Lu Yilong; Yao Zhenhua

    2003-01-01

    The principle of differential algebra is applied to analyse and calculate arbitrary order curvilinear-axis combined geometric-chromatic aberrations of electron optical systems. Expressions of differential algebraic form of high order combined aberrations are obtained and arbitrary order combined aberrations can be calculated numerically. As an example, a typical wide electron beam focusing system with curved optical axes named magnetic immersion lens has been studied. All the second-order and third-order combined geometric-chromatic aberrations of the lens have been calculated, and the patterns of the corresponding geometric aberrations and combined aberrations have been given as well

  3. Combination of perindopril/indapamide in secondary prevention of stroke and other vascular events: A combined analysis of ADVANCE, PROGRESS and HYVET trials

    Directory of Open Access Journals (Sweden)

    Sougat Sourendra Sarkar

    2011-03-01

    Full Text Available Perindopril/indapamide combination has been shown to reduce cardiovascular risk in different groups of patients. A total of 18,529 patients (9,272 receiving perindopril/indapamide and 9,257 receiving placebo were included in this meta-analysis involving three large randomized clinical trials-ADVANCE, PROGRESS and HYVET. A non-significant reduction in fatal and non-fatal stroke was seen (Odds ratio 0.73; 95% Confidence Interval 0.49 to 1.09; z=1.52 and p= 0.13. The combination was associated with a significantly reduction of vascular death (Odds ratio 0.79; 95% Confidence Interval 0.69 to 0.90; z=3.48 and p=0.0005 and major cardio-vascular events (Odds ratio 0.72; 95% Confidence Interval 0.53 to 0.97; z=2.15 and p= 0.03. Fixed-combination of Perindopril and indapamide substantially reduced major cardiovascular event and vascular death. However, effect on stroke needs further evaluation.

  4. Do anti-malarials in Africa meet quality standards? The market penetration of non quality-assured artemisinin combination therapy in eight African countries.

    Science.gov (United States)

    Newton, Paul N; Hanson, Kara; Goodman, Catherine

    2017-05-25

    Quality of artemisinin-based combination therapy (ACT) is important for ensuring malaria parasite clearance and protecting the efficacy of artemisinin-based therapies. The extent to which non quality-assured ACT (non-QAACT), or those not granted global regulatory approval, are available and used to treat malaria in endemic countries is poorly documented. This paper uses national and sub-national medicine outlet surveys conducted in eight study countries (Benin, Kinshasa and Kantanga [Democratic Republic of the Congo, DRC], Kenya, Madagascar, Nigeria, Tanzania, Uganda and Zambia) between 2009 and 2015 to describe the non-QAACT market and to document trends in availability and distribution of non-QAACT in the public and private sector. In 2014/15, non-QAACT were most commonly available in Kinshasa (83%), followed by Katanga (53%), Nigeria (48%), Kenya (42%), and Uganda (33%). Non-QAACT accounted for 20% of the market share in the private sector in Kenya, followed by Benin and Uganda (19%), Nigeria (12%) and Zambia (8%); this figure was 27% in Katanga and 40% in Kinshasa. Public sector non-QAACT availability and distribution was much lower, with the exception of Zambia (availability, 85%; market share, 32%). Diverse generics and formulations were available, but non-QAACT were most commonly artemether-lumefantrine (AL) or dihydroartemisinin-piperaquine (DHA PPQ), in tablet formulation, imported, and distributed in urban areas at either pharmacies or drug stores. The number of unique manufacturers supplying non-QAACT to each country ranged from 9 in Uganda to 92 in Nigeria. Addressing the availability and distribution of non-QAACT will require effective private sector engagement and evidence-based strategies to address provider and consumer demand for these products. Given the variation in non-QAACT markets observed across the eight study countries, active efforts to limit registration, importation and distribution of non-QAACT must be tailored to the country context

  5. Exergy and exergoeconomic analysis of a Compressed Air Energy Storage combined with a district energy system

    International Nuclear Information System (INIS)

    Bagdanavicius, Audrius; Jenkins, Nick

    2014-01-01

    Highlights: • CAES and CAES with thermal storage systems were investigated. • The potential for using heat generated during the compression stage was analysed. • CAES-TS has the potential to be used both as energy storage and heat source. • CAES-TS could be a useful tool for balancing overall energy demand and supply. - Abstract: The potential for using heat generated during the compression stage of a Compressed Air Energy Storage system was investigated using exergy and exergoeconomic analysis. Two Compressed Air Energy Storage systems were analysed: Compressed Air Energy Storage (CAES) and Compressed Air Energy Storage combined with Thermal Storage (CAES-TS) connected to a district heating network. The maximum output of the CAES was 100 MWe and the output of the CAES-TS was 100 MWe and 105 MWth. The study shows that 308 GW h/year of electricity and 466 GW h/year of fuel are used to generate 375 GW h/year of electricity. During the compression of air 289 GW h/year of heat is generated, which is wasted in the CAES and used for district heating in the CAES-TS system. Energy efficiency of the CAES system was around 48% and the efficiency of CAES-TS was 86%. Exergoeconomic analysis shows that the exergy cost of electricity generated in the CAES was 13.89 ¢/kW h, and the exergy cost of electricity generated in the CAES-TS was 11.20 ¢/kW h. The exergy cost of heat was 22.24 ¢/kW h in the CAES-TS system. The study shows that CAES-TS has the potential to be used both as energy storage and heat source and could be a useful tool for balancing overall energy demand and supply

  6. Combined evaluation of nutrition and hydration in dialysis patients with bioelectrical impedance vector analysis (BIVA).

    Science.gov (United States)

    Piccoli, Antonio; Codognotto, Marta; Piasentin, Paola; Naso, Agostino

    2014-08-01

    Body hydration changes continuously in hemodialysis patients. The Subjective Global Assessment (SGA) is used for the nutritional evaluation but it does not allow a direct evaluation of hydration. Bioelectrical impedance vector analysis (BIVA) is very sensitive to hydration. The potential of the combined evaluation of hydration and nutrition with SGA and BIVA is still lacking. Observational cross-sectional study on 130 (94 Male) uremic patients undergoing chronic hemodialysis three times a week. Nutritional status was evaluated with the SGA. Each subject was classified as SGA-A (normal nutritional status), SGA-B (moderate malnutrition), or SGA-C (severe malnutrition). Body hydration was evaluated with BIVA. The two vector components resistance (R) and reactance (Xc) were normalized by the subject's height and standardized as bivariate Z-score, i.e. Z(R) and Z(Xc). Undernutrition influenced impedance vector distribution both before and after a dialysis session. In pre-dialysis, the mean vector of SGA A was inside the 50% tolerance ellipse. In SGA B and C, Z(R) was increased and Z(Xc) decreased, indicating a progressive loss of soft tissue mass. Fluid removal with dialysis increased both Z(R) and Z(Xc) in SGA A and B but not in C. With ROC curve analysis on the slope of increase, we found the cutoff value of 27.8° below which undernutrition was present, either moderate or severe. The area under the ROC curve was 77.7° (95% CI 69.5-84.5, P hydration in each SGA category can be detected with BIVA. Copyright © 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

  7. ANALYSIS OF TRICKLE BED AND PACKED BUBBLE COLUMN BIOREACTORS FOR COMBINED CARBON OXIDATION AND NITRIFICATION

    Directory of Open Access Journals (Sweden)

    Iliuta I.

    2002-01-01

    Full Text Available Biological removal of nitrogen and carbon by combined nitrification-oxidation in gas-liquid trickle-bed reactors (TBRs and packed bubble columns (PBCs was analyzed theoretically using a transient two-dimensional model. The model describes TBR and PBC performances at steady state as well as their transient response to a pulse or step increase in inlet methanol and NH4+-nitrogen concentrations. The hydrodynamic parameters were determined from residence time distribution measurements, using an imperfect pulse method for time-domain analysis of nonideal pulse tracer response. A transient diffusion model of the tracer in the porous particle coupled with the piston-dispersion-exchange model was used to interpret the residence time distribution curves obtained. Gas-liquid mass transfer parameters were determined by a stationary method based on the least-squares fit of the calculated concentration profiles in gas phase to the experimental values. Analysis of steady-state performances showed that under like operating conditions, the TBR outperforms the PBC in terms of conversions. A pulse change in the inlet methanol or NH4+-nitrogen concentration causes a negligible transient change in the outlet methanol concentration and a negligible or high transient change in the outlet NH4+-nitrogen concentration. A step change in the inlet methanol concentration causes the negligible transient change in the methanol outlet concentration and a relatively important transient change in the NH4+-nitrogen outlet concentration. A step increase in the NH4+-nitrogen inlet concentration induces a drastic transient change in the NH4+-nitrogen outlet concentration but a negligible transient change in the methanol outlet concentration.

  8. Combination of Accumulated Motion and Color Segmentation for Human Activity Analysis

    Directory of Open Access Journals (Sweden)

    Briassouli Alexia

    2008-01-01

    Full Text Available Abstract The automated analysis of activity in digital multimedia, and especially video, is gaining more and more importance due to the evolution of higher-level video processing systems and the development of relevant applications such as surveillance and sports. This paper presents a novel algorithm for the recognition and classification of human activities, which employs motion and color characteristics in a complementary manner, so as to extract the most information from both sources, and overcome their individual limitations. The proposed method accumulates the flow estimates in a video, and extracts "regions of activity" by processing their higher-order statistics. The shape of these activity areas can be used for the classification of the human activities and events taking place in a video and the subsequent extraction of higher-level semantics. Color segmentation of the active and static areas of each video frame is performed to complement this information. The color layers in the activity and background areas are compared using the earth mover's distance, in order to achieve accurate object segmentation. Thus, unlike much existing work on human activity analysis, the proposed approach is based on general color and motion processing methods, and not on specific models of the human body and its kinematics. The combined use of color and motion information increases the method robustness to illumination variations and measurement noise. Consequently, the proposed approach can lead to higher-level information about human activities, but its applicability is not limited to specific human actions. We present experiments with various real video sequences, from sports and surveillance domains, to demonstrate the effectiveness of our approach.

  9. Combination of Accumulated Motion and Color Segmentation for Human Activity Analysis

    Directory of Open Access Journals (Sweden)

    Ioannis Kompatsiaris

    2008-03-01

    Full Text Available The automated analysis of activity in digital multimedia, and especially video, is gaining more and more importance due to the evolution of higher-level video processing systems and the development of relevant applications such as surveillance and sports. This paper presents a novel algorithm for the recognition and classification of human activities, which employs motion and color characteristics in a complementary manner, so as to extract the most information from both sources, and overcome their individual limitations. The proposed method accumulates the flow estimates in a video, and extracts “regions of activity” by processing their higher-order statistics. The shape of these activity areas can be used for the classification of the human activities and events taking place in a video and the subsequent extraction of higher-level semantics. Color segmentation of the active and static areas of each video frame is performed to complement this information. The color layers in the activity and background areas are compared using the earth mover's distance, in order to achieve accurate object segmentation. Thus, unlike much existing work on human activity analysis, the proposed approach is based on general color and motion processing methods, and not on specific models of the human body and its kinematics. The combined use of color and motion information increases the method robustness to illumination variations and measurement noise. Consequently, the proposed approach can lead to higher-level information about human activities, but its applicability is not limited to specific human actions. We present experiments with various real video sequences, from sports and surveillance domains, to demonstrate the effectiveness of our approach.

  10. A combined analysis of North American case-control studies of residential radon and lung cancer.

    Science.gov (United States)

    Krewski, Daniel; Lubin, Jay H; Zielinski, Jan M; Alavanja, Michael; Catalan, Vanessa S; Field, R William; Klotz, Judith B; Létourneau, Ernest G; Lynch, Charles F; Lyon, Joseph L; Sandler, Dale P; Schoenberg, Janet B; Steck, Daniel J; Stolwijk, Jan A; Weinberg, Clarice; Wilcox, Homer B

    2006-04-01

    Cohort studies have consistently shown underground miners exposed to high levels of radon to be at excess risk of lung cancer, and extrapolations based on those results indicate that residential radon may be responsible for nearly 10-15% of all lung cancer deaths per year in the United States. However, case-control studies of residential radon and lung cancer have provided ambiguous evidence of radon lung cancer risks. Regardless, alpha-particle emissions from the short-lived radioactive radon decay products can damage cellular DNA. The possibility that a demonstrated lung carcinogen may be present in large numbers of homes raises a serious public health concern. Thus, a systematic analysis of pooled data from all North American residential radon studies was undertaken to provide a more direct characterization of the public health risk posed by prolonged radon exposure. To evaluate the risk associated with prolonged residential radon exposure, a combined analysis of the primary data from seven large scale case-control studies of residential radon and lung cancer risk was conducted. The combined data set included a total of 4081 cases and 5281 controls, representing the largest aggregation of data on residential radon and lung cancer conducted to date. Residential radon concentrations were determined primarily by a-track detectors placed in the living areas of homes of the study subjects in order to obtain an integrated 1-yr average radon concentration in indoor air. Conditional likelihood regression was used to estimate the excess risk of lung cancer due to residential radon exposure, with adjustment for attained age, sex, study, smoking factors, residential mobility, and completeness of radon measurements. Although the main analyses were based on the combined data set as a whole, we also considered subsets of the data considered to have more accurate radon dosimetry. This included a subset of the data involving 3662 cases and 4966 controls with a-track radon

  11. Combination of various data analysis techniques for efficient track reconstruction in very high multiplicity events

    Science.gov (United States)

    Siklér, Ferenc

    2017-08-01

    A novel combination of established data analysis techniques for reconstructing charged-particles in high energy collisions is proposed. It uses all information available in a collision event while keeping competing choices open as long as possible. Suitable track candidates are selected by transforming measured hits to a binned, three- or four-dimensional, track parameter space. It is accomplished by the use of templates taking advantage of the translational and rotational symmetries of the detectors. Track candidates and their corresponding hits, the nodes, form a usually highly connected network, a bipartite graph, where we allow for multiple hit to track assignments, edges. In order to get a manageable problem, the graph is cut into very many minigraphs by removing a few of its vulnerable components, edges and nodes. Finally the hits are distributed among the track candidates by exploring a deterministic decision tree. A depth-limited search is performed maximizing the number of hits on tracks, and minimizing the sum of track-fit χ2. Simplified but realistic models of LHC silicon trackers including the relevant physics processes are used to test and study the performance (efficiency, purity, timing) of the proposed method in the case of single or many simultaneous proton-proton collisions (high pileup), and for single heavy-ion collisions at the highest available energies.

  12. A scheme for racquet sports video analysis with the combination of audio-visual information

    Science.gov (United States)

    Xing, Liyuan; Ye, Qixiang; Zhang, Weigang; Huang, Qingming; Yu, Hua

    2005-07-01

    As a very important category in sports video, racquet sports video, e.g. table tennis, tennis and badminton, has been paid little attention in the past years. Considering the characteristics of this kind of sports video, we propose a new scheme for structure indexing and highlight generating based on the combination of audio and visual information. Firstly, a supervised classification method is employed to detect important audio symbols including impact (ball hit), audience cheers, commentator speech, etc. Meanwhile an unsupervised algorithm is proposed to group video shots into various clusters. Then, by taking advantage of temporal relationship between audio and visual signals, we can specify the scene clusters with semantic labels including rally scenes and break scenes. Thirdly, a refinement procedure is developed to reduce false rally scenes by further audio analysis. Finally, an exciting model is proposed to rank the detected rally scenes from which many exciting video clips such as game (match) points can be correctly retrieved. Experiments on two types of representative racquet sports video, table tennis video and tennis video, demonstrate encouraging results.

  13. Experimental And Theoretical Stress Analysis For Composite Plate Under Combined Load

    Directory of Open Access Journals (Sweden)

    Emad Qasim Hussein

    2017-12-01

    Full Text Available The combined effects of thermal and mechanical loadings on the distribution of stress-strain for E-glass fiber /polyester composite plates are investigated experimentally and numerically. The experimental work has been carried out by applying to a uniform temperature and tensile load on the composite plate inside the furnace and the deformation of plate measured by a dial gauge. Two parameter studies, the fiber volume fraction and fiber orientation on the stress-strain for plates subjected to identical mechanical and temperature gradient. The results presented showed that, the maximum absolute of total strain in longitudinal direction occurred at 50 N tension load and fiber angle 60º, while the minimum absolute values of it occurred at 15 N tension loads and fiber angle 0º. However the maximum absolute of total strain in transverse direction occurred at 15N tension load and fiber angle 0º, while the minimum absolute values of it are obtained at 50 N tension loads and fiber angle 60º. Also, the total strain in longitudinal and transverse direction decrease with increasing the fiber volume fraction. Comparison of the results in the experimental test with the numerical analysis of the total strain and evaluated the agreement between the two methods used, the maximum discrepancywas 20%.

  14. Blind Separation of Acoustic Signals Combining SIMO-Model-Based Independent Component Analysis and Binary Masking

    Directory of Open Access Journals (Sweden)

    Hiekata Takashi

    2006-01-01

    Full Text Available A new two-stage blind source separation (BSS method for convolutive mixtures of speech is proposed, in which a single-input multiple-output (SIMO-model-based independent component analysis (ICA and a new SIMO-model-based binary masking are combined. SIMO-model-based ICA enables us to separate the mixed signals, not into monaural source signals but into SIMO-model-based signals from independent sources in their original form at the microphones. Thus, the separated signals of SIMO-model-based ICA can maintain the spatial qualities of each sound source. Owing to this attractive property, our novel SIMO-model-based binary masking can be applied to efficiently remove the residual interference components after SIMO-model-based ICA. The experimental results reveal that the separation performance can be considerably improved by the proposed method compared with that achieved by conventional BSS methods. In addition, the real-time implementation of the proposed BSS is illustrated.

  15. Nitrate removal and microbial analysis by combined micro-electrolysis and autotrophic denitrification.

    Science.gov (United States)

    Xing, Wei; Li, Desheng; Li, Jinlong; Hu, Qianyi; Deng, Shihai

    2016-07-01

    A process combining micro-electrolysis and autotrophic denitrification (CEAD) with iron-carbon micro-electrolysis carriers was developed for nitrate removal. The process was performed using organic-free influent with a NO3(-)-N concentration of 40.0±3.0mg/L and provided an average nitrate removal efficiency of 95% in stable stages. The total nitrogen removal efficiency reached 75%, with 21% of NO3(-)-N converted into NH4(+)-N. The corresponding hydraulic retention time was 8-10h, and the optimal pH ranged from 8.5 to 9.5. Microbial analysis with high-throughput sequencing revealed that dominant microorganisms in the reactor belonged to the classes of β-, γ-, and α-Proteobacteria. The abundance of the genera Thermomonas significantly increased during the operation, comprising 21.4% and 24.1% in sludge attached to the carriers in the middle and at the bottom of the reactor, respectively. The developed CEAD achieved efficient nitrate removal from water without organics, which is suitable for practical application. Copyright © 2016. Published by Elsevier Ltd.

  16. Spatiotemporal analysis of tropical disease research combining Europe PMC and affiliation mapping web services.

    Science.gov (United States)

    Palmblad, Magnus; Torvik, Vetle I

    2017-01-01

    Tropical medicine appeared as a distinct sub-discipline in the late nineteenth century, during a period of rapid European colonial expansion in Africa and Asia. After a dramatic drop after World War II, research on tropical diseases have received more attention and research funding in the twenty-first century. We used Apache Taverna to integrate Europe PMC and MapAffil web services, containing the spatiotemporal analysis workflow from a list of PubMed queries to a list of publication years and author affiliations geoparsed to latitudes and longitudes. The results could then be visualized in the Quantum Geographic Information System (QGIS). Our workflows automatically matched 253,277 affiliations to geographical coordinates for the first authors of 379,728 papers on tropical diseases in a single execution. The bibliometric analyses show how research output in tropical diseases follow major historical shifts in the twentieth century and renewed interest in and funding for tropical disease research in the twenty-first century. They show the effects of disease outbreaks, WHO eradication programs, vaccine developments, wars, refugee migrations, and peace treaties. Literature search and geoparsing web services can be combined in scientific workflows performing a complete spatiotemporal bibliometric analyses of research in tropical medicine. The workflows and datasets are freely available and can be used to reproduce or refine the analyses and test specific hypotheses or look into particular diseases or geographic regions. This work exceeds all previously published bibliometric analyses on tropical diseases in both scale and spatiotemporal range.

  17. Welding distortion analysis of multipass joint combination with different sequences using 3D FEM and experiment

    International Nuclear Information System (INIS)

    Manurung, Yupiter H.P.; Lidam, Robert Ngendang; Rahim, M. Ridzwan; Zakaria, M. Yusof; Redza, M. Ridhwan; Sulaiman, M. Shahar; Tham, Ghalib; Abas, Sunhaji K.

    2013-01-01

    This paper presents an investigation of the welding sequence effect on induced angular distortion using FEM and experiments. The specimen of a combined joint geometry was modeled and simulated using Multipass Welding Advisor (MWA) in SYSWELD 2010 based on the thermal-elastic-plastic approach with low manganese carbon steel S3355J2G3 as specimen material and Goldak's double ellipsoid as heat source model. To validate the simulation results, a series of experiments was conducted with two different welding sequences using automated welding process, low carbon steel as parent metal, digital GMAW power source with premixed shielding gas and both-sided clamping technique. Based on the results, it was established that the thermo-elastic-plastic 3D FEM analysis shows good agreement with experimental results and the welding sequence “from outside to inside” induced less angular distortion compared to “from inside to outside”. -- Highlights: • 3D FEM was used to analyze the welding distortion on two different sequences. • Simulation results were validated with experiments using automated welding system. • Simulation results and experiments showed acceptable accuracy. • Welding sequence “outside–inside” showed less distortion than “inside–outside”

  18. Thermoeconomic analysis of Biomass Integrated Gasification Gas Turbine Combined Cycle (BIG GT CC) cogeneration plant

    Energy Technology Data Exchange (ETDEWEB)

    Arrieta, Felipe Raul Ponce; Lora, Electo Silva [Escola Federal de Engenharia de Itajuba, MG (Brazil). Nucleo de Estudos de Sistemas Termicos]. E-mails: aponce@iem.efei.br; electo@iem.efei.br; Perez, Silvia Azucena Nebra de [Universidade Estadual de Campinas, SP (Brazil). Faculdade de Engenharia Mecanica. Dept. de Energia]. E-mail: sanebra@fem. unicamp.br

    2000-07-01

    Using thermoeconomics as a tool to identify the location and magnitude of the real thermodynamic losses (energy waste, or exergy destruction and exergy losses) it is possible to assess the production costs of each product (electric power and heat) and the exergetic and exergoeconomic cost of each flow in a cogeneration plant to assist in decision-marketing procedures concerning to plant design, investment, operation and allocations of research funds. Thermo economic analysis of Biomass Integrated Gasification Gas Turbine Combined Cycle (BIG GT CC) cogeneration plant for its applications in sugar cane mills brings the following results: the global exergetic efficiency is low; the highest irreversibilities occur in the following equipment, by order: scrubber (38%), gas turbine (16%), dryer (12%), gasifier and HRSG (6%); due to the adopted cost distribution methodology, the unit exergetic cost of the heat (4,11) is lower than electricity (4,71); the lower market price of biomass is one of the most sensible parameter in the possible implementation of BIG-GT technology in sugar cane industry; the production costs are 31 US$/MWh and 32 US$/MWh for electricity and heat, respectively. The electricity cost is, after all, competitive with the actual market price. The electricity and heat costs are lower or almost equal than other values reported for actual Rankine cycle cogeneration plants. (author)

  19. Additivity versus repair inhibition in fractionated treatments combining drugs and X rays: a theoretical analysis

    International Nuclear Information System (INIS)

    Begg, A.C.

    1987-01-01

    Drugs which inhibit the repair of radiation damage could potentially be useful for enhancing the effects of radiotherapy. In pre-clinical combined modality studies, however, it is often difficult to state with certainty whether or not a drug has inhibited radiation damage repair. This paper shows that several commonly used parameters for assessing repair can give the wrong answer regarding the presence of drug-induced repair inhibition. These parameters are; the difference in radiation dose between 1 and n fractions to give the same effect, the fractional recovered dose per fraction interval, FR, and the related parameter FREC. A further parameter used for treatment comparisons is the enhancement ratio for the drug (D.E.R.; ratio of radiation doses, with and without drug, to cause a given effect). An increasing D.E.R. with increasing number of radiation fractions has been taken as an indication that the drug inhibited repair. The present report demonstrates that this, too, can be misleading. From an analysis based on a linear-quadratic survival curve for X rays, it is suggested that deriving and comparing alpha/beta ratios (ratio of the linea to quadratic coefficients) gives the best indication of drug-induced changes in survival curve shape which may reflect underlying changes in repair capacity

  20. Algorithms for Image Analysis and Combination of Pattern Classifiers with Application to Medical Diagnosis

    Science.gov (United States)

    Georgiou, Harris

    2009-10-01

    Medical Informatics and the application of modern signal processing in the assistance of the diagnostic process in medical imaging is one of the more recent and active research areas today. This thesis addresses a variety of issues related to the general problem of medical image analysis, specifically in mammography, and presents a series of algorithms and design approaches for all the intermediate levels of a modern system for computer-aided diagnosis (CAD). The diagnostic problem is analyzed with a systematic approach, first defining the imaging characteristics and features that are relevant to probable pathology in mammo-grams. Next, these features are quantified and fused into new, integrated radio-logical systems that exhibit embedded digital signal processing, in order to improve the final result and minimize the radiological dose for the patient. In a higher level, special algorithms are designed for detecting and encoding these clinically interest-ing imaging features, in order to be used as input to advanced pattern classifiers and machine learning models. Finally, these approaches are extended in multi-classifier models under the scope of Game Theory and optimum collective deci-sion, in order to produce efficient solutions for combining classifiers with minimum computational costs for advanced diagnostic systems. The material covered in this thesis is related to a total of 18 published papers, 6 in scientific journals and 12 in international conferences.

  1. Analysis of potential energy, economic and environmental savings in residential buildings: Solar collectors combined with microturbines

    International Nuclear Information System (INIS)

    Suárez, I.; Prieto, M.M.; Fernández, F.J.

    2013-01-01

    Highlights: ► Centralization of energy systems for a group of buildings improves profitability. ► Thermal solar systems are economically interesting even in low radiation locations. ► Regulations currently in force determine the feasibility of high efficiency energy systems. - Abstract: This paper presents an analysis of a combined solar-cogeneration installation for providing energy services in a set of four residential buildings. Different configurations as regards the number of collectors and their orientation, the number of buildings grouped together, the type of microturbines used in the cogeneration system and their daily and annual operating period are studied from the legal, economic and environmental perspectives. The installation that fulfils the minimum requirements of the solar system coverage and the cogeneration system efficiency currently in force, and simultaneously leads to the highest energy, economic and environmental savings is the one that integrates both technologies and centralises the installation for the four buildings together. A payback period lower than 8 years is obtained that makes this investment recommendable, but it is also concluded that maintaining the existing subsidies for these technologies and lowering the costs of the equipment, are essential factors to ensure the feasibility of this type of installations

  2. Combined theoretical and experimental analysis of processes determining cathode performance in solid oxide fuel cells.

    Science.gov (United States)

    Kuklja, M M; Kotomin, E A; Merkle, R; Mastrikov, Yu A; Maier, J

    2013-04-21

    Solid oxide fuel cells (SOFC) are under intensive investigation since the 1980's as these devices open the way for ecologically clean direct conversion of the chemical energy into electricity, avoiding the efficiency limitation by Carnot's cycle for thermochemical conversion. However, the practical development of SOFC faces a number of unresolved fundamental problems, in particular concerning the kinetics of the electrode reactions, especially oxygen reduction reaction. We review recent experimental and theoretical achievements in the current understanding of the cathode performance by exploring and comparing mostly three materials: (La,Sr)MnO3 (LSM), (La,Sr)(Co,Fe)O3 (LSCF) and (Ba,Sr)(Co,Fe)O3 (BSCF). Special attention is paid to a critical evaluation of advantages and disadvantages of BSCF, which shows the best cathode kinetics known so far for oxides. We demonstrate that it is the combined experimental and theoretical analysis of all major elementary steps of the oxygen reduction reaction which allows us to predict the rate determining steps for a given material under specific operational conditions and thus control and improve SOFC performance.

  3. Analysis of a combined heating and cooling system model under different operating strategies

    Science.gov (United States)

    Dzierzgowski, Mieczysław; Zwierzchowski, Ryszard

    2017-11-01

    The paper presents an analysis of a combined heating and cooling system model under different operating strategies. Cooling demand for air conditioning purposes has grown steadily in Poland since the early 1990s. The main clients are large office buildings and shopping malls in downtown locations. Increased demand for heat in the summer would mitigate a number of problems regarding District Heating System (DHS) operation at minimum power, affecting the average annual price of heat (in summertime the share of costs related to transport losses is a strong cost factor). In the paper, computer simulations were performed for different supply network water temperature, assuming as input, real changes in the parameters of the DHS (heat demand, flow rates, etc.). On the basis of calculations and taking into account investment costs of the Absorption Refrigeration System (ARS) and the Thermal Energy Storage (TES) system, an optimal capacity of the TES system was proposed to ensure smooth and efficient operation of the District Heating Plant (DHP). Application of ARS with the TES system in the DHS in question increases net profit by 19.4%, reducing the cooling price for consumers by 40%.

  4. Bifurcation Observation of Combining Spiral Gear Transmission Based on Parameter Domain Structure Analysis

    Directory of Open Access Journals (Sweden)

    He Lin

    2016-01-01

    Full Text Available This study considers the bifurcation evolutions for a combining spiral gear transmission through parameter domain structure analysis. The system nonlinear vibration equations are created with piecewise backlash and general errors. Gill’s numerical integration algorithm is implemented in calculating the vibration equation sets. Based on cell-mapping method (CMM, two-dimensional dynamic domain planes have been developed and primarily focused on the parameters of backlash, transmission error, mesh frequency and damping ratio, and so forth. Solution demonstrates that Period-doubling bifurcation happens as the mesh frequency increases; moreover nonlinear discontinuous jump breaks the periodic orbit and also turns the periodic state into chaos suddenly. In transmission error planes, three cell groups which are Period-1, Period-4, and Chaos have been observed, and the boundary cells are the sensitive areas to dynamic response. Considering the parameter planes which consist of damping ratio associated with backlash, transmission error, mesh stiffness, and external load, the solution domain structure reveals that the system step into chaos undergoes Period-doubling cascade with Period-2m (m: integer periodic regions. Direct simulations to obtain the bifurcation diagram and largest Lyapunov exponent (LE match satisfactorily with the parameter domain solutions.

  5. Stochastic Multicriteria Acceptability Analysis for Evaluation of Combined Heat and Power Units

    Directory of Open Access Journals (Sweden)

    Haichao Wang

    2014-12-01

    Full Text Available Combined heat and power (CHP is a promising technology that can contribute to energy efficiency and environmental protection. More CHP-based energy systems are planned for the future. This makes the evaluation and selection of CHP systems very important. In this paper, 16 CHP units representing different technologies are taken into account for multicriteria evaluation with respect to the end users’ requirements. These CHP technologies cover a wide range of power outputs and fuel types. They are evaluated from the energy, economy and environment (3E points of view, specifically including the criteria of efficiency, investment cost, electricity cost, heat cost, CO2 production and footprint. Uncertainties and imprecision are common both in criteria measurements and weights, therefore the stochastic multicriteria acceptability analysis (SMAA model is used in aiding this decision making problem. These uncertainties are treated better using a probability distribution function and Monte Carlo simulation in the model. Moreover, the idea of “feasible weight space (FWS” which represents the union of all preference information from decision makers (DMs is proposed. A complementary judgment matrix (CJM is introduced to determine the FWS. It can be found that the idea of FWS plus CJM is well compatible with SMAA and thus make the evaluation reliable.

  6. Artificial neural network combined with principal component analysis for resolution of complex pharmaceutical formulations.

    Science.gov (United States)

    Ioele, Giuseppina; De Luca, Michele; Dinç, Erdal; Oliverio, Filomena; Ragno, Gaetano

    2011-01-01

    A chemometric approach based on the combined use of the principal component analysis (PCA) and artificial neural network (ANN) was developed for the multicomponent determination of caffeine (CAF), mepyramine (MEP), phenylpropanolamine (PPA) and pheniramine (PNA) in their pharmaceutical preparations without any chemical separation. The predictive ability of the ANN method was compared with the classical linear regression method Partial Least Squares 2 (PLS2). The UV spectral data between 220 and 300 nm of a training set of sixteen quaternary mixtures were processed by PCA to reduce the dimensions of input data and eliminate the noise coming from instrumentation. Several spectral ranges and different numbers of principal components (PCs) were tested to find the PCA-ANN and PLS2 models reaching the best determination results. A two layer ANN, using the first four PCs, was used with log-sigmoid transfer function in first hidden layer and linear transfer function in output layer. Standard error of prediction (SEP) was adopted to assess the predictive accuracy of the models when subjected to external validation. PCA-ANN showed better prediction ability in the determination of PPA and PNA in synthetic samples with added excipients and pharmaceutical formulations. Since both components are characterized by low absorptivity, the better performance of PCA-ANN was ascribed to the ability in considering all non-linear information from noise or interfering excipients.

  7. What proportion of people with hip and knee osteoarthritis meet physical activity guidelines? A systematic review and meta-analysis.

    Science.gov (United States)

    Wallis, J A; Webster, K E; Levinger, P; Taylor, N F

    2013-11-01

    To determine the proportion of people with hip and knee osteoarthritis that meet physical activity guidelines recommended for adults and older adults. Systematic review with meta-analysis of studies measuring physical activity of participants with hip and knee osteoarthritis using an activity monitor. Physical activity levels were calculated using the mean average [95% confidence interval (CI)] weighted according to sample size. Meta-analyses determined the proportion of people meeting physical activity guidelines and recommendations of (1) ≥150 min per week of moderate to vigorous physical activity (MVPA) in bouts of ≥10 min; (2) ≥150 min per week of MVPA in absence of bouts; (3) ≥10,000 steps per day and ≥7000 steps per day. The Grades of Research, Assessment, Development and Evaluation (GRADE) approach was used to determine the quality of the evidence. For knee osteoarthritis, 21 studies involving 3266 participants averaged 50 min per week (95% CI = 46, 55) of MVPA when measured in bouts of ≥10 min, 131 min per week (95% CI = 125, 137) of MVPA, and 7753 daily steps (95% CI = 7582, 7924). Proportion meta-analyses provided high quality evidence that 13% (95% CI = 7, 20) completed ≥150 min per week of MVPA in bouts of ≥10 min, low quality evidence that 41% (95% CI = 23, 61) completed ≥150 min per week of MVPA in absence of bouts, moderate quality evidence that 19% (95% CI = 8, 33) completed ≥10,000 steps per day, and low quality evidence that 48% (95% CI = 31, 65) completed ≥7000 steps per day. For hip osteoarthritis, 11 studies involving 325 participants averaged 160 min per week (95% CI = 114, 216) of MVPA when measured in bouts of ≥10 min, 189 min per week (95% CI = 166, 212) of MVPA, and 8174 daily steps (95% CI = 7670, 8678). Proportion meta-analyses provided low quality evidence that 58% (95% CI = 18, 92) completed ≥150 min per week of MVPA in absence of bouts, low quality evidence that 30% (95% CI

  8. Systematic review and network meta-analysis of combination and monotherapy treatments in disease-modifying antirheumatic drug-experienced patients with rheumatoid arthritis: analysis of American College of Rheumatology criteria scores 20, 50, and 70

    Science.gov (United States)

    Orme, Michelle E; MacGilchrist, Katherine S; Mitchell, Stephen; Spurden, Dean; Bird, Alex

    2012-01-01

    Background Biologic disease-modifying antirheumatic drugs (bDMARDs) extend the treatment choices for rheumatoid arthritis patients with suboptimal response or intolerance to conventional DMARDs. The objective of this systematic review and meta-analysis was to compare the relative efficacy of EU-licensed bDMARD combination therapy or monotherapy for patients intolerant of or contraindicated to continued methotrexate. Methods Comprehensive, structured literature searches were conducted in Medline, Embase, and the Cochrane Library, as well as hand-searching of conference proceedings and reference lists. Phase II or III randomized controlled trials reporting American College of Rheumatology (ACR) criteria scores of 20, 50, and 70 between 12 and 30 weeks’ follow-up and enrolling adult patients meeting ACR classification criteria for rheumatoid arthritis previously treated with and with an inadequate response to conventional DMARDs were eligible. To estimate the relative efficacy of treatments whilst preserving the randomized comparisons within each trial, a Bayesian network meta-analysis was conducted in WinBUGS using fixed and random-effects, logit-link models fitted to the binomial ACR 20/50/70 trial data. Results The systematic review identified 10,625 citations, and after a review of 2450 full-text papers, there were 29 and 14 eligible studies for the combination and monotherapy meta-analyses, respectively. In the combination analysis, all licensed bDMARD combinations had significantly higher odds of ACR 20/50/70 compared to DMARDs alone, except for the rituximab comparison, which did not reach significance for the ACR 70 outcome (based on the 95% credible interval). The etanercept combination was significantly better than the tumor necrosis factor-α inhibitors adalimumab and infliximab in improving ACR 20/50/70 outcomes, with no significant differences between the etanercept combination and certolizumab pegol or tocilizumab. Licensed-dose etanercept, adalimumab

  9. Accuracy Combination Test of Classical and Modern Technical Analysis: A Case Study in Stock of PT Wijaya Karya Tbk

    OpenAIRE

    Agustini Hamid

    2016-01-01

    The research aimed to measure the accuracy and combination of Classic and Modern Technical Analysis. PT Wijaya Karya Tbk (WIKA)’s stock in two periods is the sample of research. Technical analysis was used to predict stock prices by observing changes in historical share price. Practically, technical analysis is divided into Classic Technical and Modern. Research was conducted by library study and using a computer software. Microsft Excel was used for the simulation and Chart Nexus for analyzi...

  10. Combining soundscape analysis with in situ observations and oceanographic data for future ecosystem evaluation techniques.

    Science.gov (United States)

    Freeman, S. E.; Freeman, L. A.

    2016-02-01

    Coral reef ecosystems face many anthropogenic threats. There are urgent requirements for improved monitoring and management. Conventional assessment methods using SCUBA are costly and prone to bias and under-sampling. Here, three approaches to understanding coral reef ecology are combined to aid the goal of enhanced passive monitoring in the future: statistical analysis of oceanographic habitats, remote cameras for nocturnal surveys of benthic fauna, and soundscape analysis in the context of oceanographic setting and ecological metrics collected in-situ. Hawaiian reefs from Kure Atoll to the island of Hawaii, an area spanning two oceanographic habitats, are assessed. Multivariate analysis of acoustic, remote camera, and in-situ observational data showed significant differences in more than 20 percent of ecological and acoustic variables when grouped by oceanic regime, suggesting that large-scale oceanography substantially influences local ecological states and associated soundscapes. Acoustic variables further delineated sites by island, suggesting local conditions influence the soundscape to a greater degree. While the number of invertebrates (with an emphasis on crustaceans and echinoderms) imaged using remote cameras correlated with a number of acoustic metrics, an increasingly higher correlation between invertebrate density and spectral level was observed as acoustic bands increased in frequency from 2 to 20 kHz. In turn, correlation was also observed between the number of predatory fish and sound levels above 2 kHz, suggesting a connection between the number of invertebrates, sound levels at higher frequencies, and the presence of their predators. Comparisons between sound recordings and diversity indices calculated from observational and remote camera data indicate that greater diversity in fishes and benthic invertebrates is associated with a larger change in sound levels between day and night. Interdisciplinary analyses provide a novel view to underwater

  11. Economic analysis of a combined production of hydrogen-energy from empty fruit bunches

    International Nuclear Information System (INIS)

    Langè, Stefano; Pellegrini, Laura A.

    2013-01-01

    This work relates to an economic analysis and a comparison between different process solutions for the production of hydrogen and the co-production of hydrogen and energy by means of a zero emission biomass integrated supercritical water gasification (SCWG) and combined cycle power plant. The case study will be located in Malaysia. Energy will be produced in agreement with the Small Renewable Energy Power Plant (SREP) Program, promoted by the Government of Malaysia. Hydrogen is obtained by supercritical water gasification (SCWG) of empty fruit bunches (EFB), a technology of interest for the processing of biomass with high moisture content. The economic analysis has been carried out to demonstrate the feasibility of the process solutions and to compare their convenience. The feedstock is 35 Mg h −1 of empty fruit bunches (EFB), a biomass obtained in the Palm Oil Industry. The location of the site is Teluk Intak District in the State of Perak (Malaysia). The study is performed with Aspen Plus ® V7.2. The aim of this work is to investigate the economic convenience of supercritical water gasification technology applied to a potential industrial case study in order to state the possibilities and the trade-off for the production of hydrogen and the co-production of hydrogen and energy from biomass, using an innovative technology (SCWG) instead of a typical unit for syngas and energy production. The processes have been developed to reach zero emissions and zero wastes. CO 2 and solid residuals are recycled inside palm oil lifecycle. -- Highlights: • Supercritical water gasification of empty fruit bunches has been used for hydrogen production. • Malaysia Small Renewable Energy Power Plant Program is aiming to reduce by 40% its greenhouse gases emissions by 2020. • An economic analysis has been performed to assess the sustainability of hydrogen and energy production from palm oil biomass. • Carbon dioxide and solid residuals are recycled back into biomass

  12. August Meeting

    African Journals Online (AJOL)

    chifaou.amzat

    2011-10-19

    Oct 19, 2011 ... rural hometowns, where they unite with their rural-based colleagues for ... extent have they empowered the women-folk in the public sphere? ...... It would be safe, therefore, for one to conceptualise the 'August Meeting'.

  13. Public meetings

    CERN Multimedia

    Staff Association

    2014-01-01

    You were hundreds of persons to participate in our information meetings of October 3 and 6 2014, and we thank you for your participation! The full presentation is available here. A summary of the topics is available here (in french).

  14. Thermodynamic and economic analysis on geothermal integrated combined-cycle power plants

    International Nuclear Information System (INIS)

    Bettocchi, R.; Cantore, G.; Negri di Montenegro, G.; Gadda, E.

    1992-01-01

    This paper considers geothermal integrated power plants obtained matching a geothermal plant with, a two pressure level combined plant. The purpose of the paper is the evaluation of thermodynamic and economic aspects on geothermal integrated combined-cycle power plant and a comparison with conventional solutions. The results show that the integrated combined plant power is greater than the sum of combined cycle and geothermal plant powers considered separately and that the integrated plant can offer economic benefits reaching the 16% of the total capital required

  15. Energy-exergy analysis of compressor pressure ratio effects on thermodynamic performance of ammonia water combined cycle

    International Nuclear Information System (INIS)

    Mohtaram, Soheil; Chen, Wen; Zargar, T.; Lin, Ji

    2017-01-01

    Highlights: • Energy exergy analysis is conducted to find the effects of RP. • EES software is utilized to perform the detailed energy-exergy analyses. • Effects investigated through energy and exergy destruction, enthalpy, yields, etc. • Detailed results are reported showing the performance of gas and combined cycle. - Abstract: The purpose of this study is to investigate the effect of compressor pressure ratio (RP) on the thermodynamic performances of ammonia-water combined cycle through energy and exergy destruction, enthalpy temperature, yields, and flow velocity. The energy-exergy analysis is conducted on the ammonia water combined cycle and the Rankine cycle, respectively. Engineering Equation Solver (EES) software is utilized to perform the detailed analyses. Values and ratios regarding heat drop and exergy loss are presented in separate tables for different equipments. The results obtained by the energy-exergy analysis indicate that by increasing the pressure ratio compressor, exergy destruction of high-pressure compressors, intercooler, gas turbine and the special produced work of gas turbine cycle constantly increase and the exergy destruction of recuperator, in contrast, decreases continuously. In addition, the least amount of input fuel into the combined cycle is observed when the pressure ratio is no less than 7.5. Subsequently, the efficiency of the cycle in gas turbine and combined cycle is reduced because the fuel input into the combined cycle is increased.

  16. Public meetings

    CERN Multimedia

    Staff Association

    2017-01-01

    Do you have questions about the elections to the Staff Council, 2017 MERIT exercise, EVE and School, LD to IC exercise, CHIS, the Pension Fund… Come get informed and ask your questions at our public meetings. These public meetings are also an opportunity to get the more information on current issues. Benefit from this occasion to get the latest news and to discuss with the representatives of the statutory body that is the Staff Association!

  17. Use and development of coupled computer codes for the analysis of accidents at nuclear power plants. Proceedings of a technical meeting

    International Nuclear Information System (INIS)

    2007-01-01

    Computer codes are widely used in Member States for the analysis of safety at nuclear power plants (NPPs). Coupling of computer codes, a further tool for safety analysis, is especially beneficial to safety analysis. The significantly increased capacity of new computation technology has made it possible to switch to a newer generation of computer codes, which are capable of representing physical phenomena in detail and include a more precise consideration of multidimensional effects. The coupling of advanced, best estimate computer codes is an efficient method of addressing the multidisciplinary nature of reactor accidents with complex interfaces between disciplines. Coupling of computer codes is very advantageous for studies which relate to licensing of new NPPs, safety upgrading programmes for existing plants, periodic safety reviews, renewal of operating licences, use of safety margins for reactor power uprating, better utilization of nuclear fuel and higher operational flexibility, justification for lifetime extensions, development of new emergency operating procedures, analysis of operational events and development of accident management programmes. In this connection, the OECD/NEA Working Group on the Analysis and Management of Accidents (GAMA) recently highlighted the application of coupled computer codes as an area of 'high collective interest'. Coupled computer codes are being developed in many Member States independently or within small groups composed of several technical organizations. These developments revealed that there are many types and methods of code coupling. In this context, it was believed that an exchange of views and experience while addressing these problems at an international meeting could contribute to the more efficient and reliable use of advanced computer codes in nuclear safety applications. The present publication constitutes the report on the Technical Meeting on Progress in the Development and Use of Coupled Codes for Accident

  18. Accuracy Combination Test of Classical and Modern Technical Analysis: A Case Study in Stock of PT Wijaya Karya Tbk

    Directory of Open Access Journals (Sweden)

    Agustini Hamid

    2016-05-01

    Full Text Available The research aimed to measure the accuracy and combination of Classic and Modern Technical Analysis. PT Wijaya Karya Tbk (WIKA’s stock in two periods is the sample of research. Technical analysis was used to predict stock prices by observing changes in historical share price. Practically, technical analysis is divided into Classic Technical and Modern. Research was conducted by library study and using a computer software. Microsft Excel was used for the simulation and Chart Nexus for analyzing Modern Technical Analysis. The research period started in January 1, 2013 until December 31, 2013 and January 1, 2014 until December 31, 2014. The Classic Technical Analysis used Support, Resistance, Trendline, and Flag Patern. Meanwhile for Modern Technical Analysis used Moving Average, Stochastic, Moving Average Convergence Divergence (MACD indicator. The Classical Technical Analysis gave less result than Modern Technical Analysis. The classical give 14 investment decisions in two periods. The average return of Classical Technical is 15,50%. Meanwhile the Modern Technical Analysis gave 18 investment decisions in two periods. The average return of Modern Technical is 18,14%. Combining Classic Technical Analysis and Modern Technical Analysis gave 20 investment decisions with the average rate of return 20,41%.

  19. Meta-analysis of gemcitabine and cisplatin combination chemotherapy versus gemcitabine alone for pancreatic cancer

    Directory of Open Access Journals (Sweden)

    Diyu Huang

    2016-01-01

    Conclusions: Overall response rate, stable disease, and progressive disease, as well as 1-year survival rate in patients who received GEM + CIS, were superior to those treated with GEM alone. Combination chemotherapy with GEM and CIS may offer greater benefits in the treatment of pancreatic cancer than that of GEM alone although the combination group had higher hematological toxicities.

  20. Combinations of techniques that effectively change health behavior : evidence from meta-Cart analysis

    NARCIS (Netherlands)

    Dusseldorp, E.; Buuren, S. van; Genugten, L. van; Verheijden, M.W.; Empelen, P. van

    2014-01-01

    Objective: Many health-promoting interventions combine multiple behavior change techniques (BCTs) to maximize effectiveness. Although, in theory, BCTs can amplify each other, the available meta-analyses have not been able to identify specific combinations of techniques that provide synergistic

  1. Green Quantification Strategy Combined with Chemometric Analysis for Triglycerides in Seeds Used in Traditional Chinese Medicine.

    Science.gov (United States)

    Hou, Jin-Jun; Guo, Ji-Ling; Cao, Chun-Mei; Yao, Shuai; Long, Hua-Li; Cai, Lu-Ying; Da, Juan; Wu, Wan-Ying; Guo, De-An

    2018-04-01

    Triglycerides are the primary constituents of some seed kernels used in traditional Chinese medicine. Quality control of seed kernels containing multiple components with an environmentally friendly method is indispensable for establishing their quality standards (called monographs) in pharmacopeia. Using coix seeds (Semen Coicis) as an example, a green quantification strategy was proposed by combining C 8 core-shell particles with single standard to determine multicomponent technologies to quantify seven triglycerides simultaneously. A core-shell column, namely, Halo C 8 (3.0 × 100 mm, 2.7 µm), was used. Methanol was used as the mobile phase at a flow rate of 0.3 mL/min, enabling UV detection of the elutes. Seven triglycerides were well separated in 20 min, and simultaneously quantified using triolein as a single standard. The conversion factor for each standard was set as 1.0 on ELSD, while for the conversion factors at 203 nm, the values increased with the reduction of linoleate. The recovery values were all in the range of 97 - 107% (RSD < 3.0%). The RSD values of precision, including intraday and intermediate precision, were < 3.0% when the total content of triglycerides was calculated. The linearity reached r ≥ 0.9990, and the limit of quantitation reached 40 - 70 ng. Forty-nine batches of coix seeds from four different places of origins and eight batches of adulterants were evaluated and differentiated using principal component analysis. In addition, the validated method was used successfully to quantity seven triglycerides in Semen Persicae, Semen Armeniacae Amarum, and Semen Pruni. Georg Thieme Verlag KG Stuttgart · New York.

  2. Metabolomic analysis for combined hepatotoxicity of chlorpyrifos and cadmium in rats

    International Nuclear Information System (INIS)

    Xu, Ming-Yuan; Wang, Pan; Sun, Ying-Jian; Wu, Yi-Jun

    2017-01-01

    Pesticides and heavy metals are widespread environmental pollutants. Although the acute toxicity of organophosphorus pesticide chlorpyrifos (CPF) and toxic heavy metal cadmium (Cd) is well characterized, the combined toxicity of CPF and Cd, especially the hepatotoxicity of the two chemicals with long-term exposure at a low dose, remained unclear. In this study, we investigated the toxicity in the liver of rats upon subchronic exposure to CPF and Cd at environmentally relevant doses. Rats were given three different doses (1/135 LD 50 , 1/45 LD 50 and 1/15 LD 50 ) of CPF and Cd as well as their mixtures by oral gavage for 90 days. After treatment, the liver tissues were subjected to histopathological examination and biochemical analysis. Gas chromatography-mass spectrometry (GC–MS) was used to analyze the metabolomic changes in the rat liver upon CPF, Cd and their mixtures treatment. The results showed that CPF and Cd-induced oxidative damage and disrupted energy, amino acid, and fatty acid metabolism in the liver. Eleven biomarkers in liver were identified for CPF-, Cd-, and their mixture-treated rats. Three metabolites, i.e., butanedioic acid, myo-inositol, and urea, were identified as unique biomarkers for the mixture-treated rats. Moreover, we found that Cd could accelerate the metabolism of CPF in the liver when given together to the rats, which may lead to the potential antagonistic interaction between CPF and Cd. In conclusion, our results indicated that even at environmentally relevant doses, CPF and Cd could disrupt the liver metabolism. In addition, the accelerated metabolism of CPF by Cd may lead to their potential antagonistic interaction.

  3. Combined endoscopy, aspiration, and biopsy analysis for identifying infectious colitis in patients with ileocecal ulcers.

    Science.gov (United States)

    Nagata, Naoyoshi; Shimbo, Takuro; Sekine, Katsunori; Tanaka, Shouhei; Niikura, Ryota; Mezaki, Kazuhisa; Morino, Eriko; Yazaki, Hirohisa; Igari, Toru; Ohmagari, Norio; Akiyama, Junichi; Oka, Shinichi; Uemura, Naomi

    2013-06-01

    The ileocecal area is commonly involved in infection and inflammatory colonic diseases, but differential diagnosis can be difficult. We identified definitive endoscopic findings and a sample collection method for diagnosing infectious colitis. In a retrospective study, we analyzed data on 128 patients with ileocecal ulcer who underwent colonoscopy from 2007-2011 at the National Center for Global Health and Medicine in Tokyo, Japan. We collected information on location, size, number, and distinctive endoscopic findings and estimated diagnostic odds ratios (ORs). The sensitivities of microscopy, culture, polymerase chain reaction, and histologic methods in identifying patients with infection were compared with those of standard stool, endoscopic aspirated intestinal fluid, or biopsy analyses. Of the 128 patients, 100 had infections, and 28 had Crohn's disease, Behçet's disease, or other inflammatory diseases. Predictive endoscopic findings were as follows: for amebiasis of the cecum (OR, 17.8), with exudates (OR, 13.9) and round-shaped ulcer (OR, 5.77); for tuberculosis (TB) with transverse-shaped ulcer (OR, 175), scar (OR, 34.6), linear-shaped ulcer (OR, 23.9), or ≥10 mm (OR, 14.0); for cytomegalovirus with round-shaped ulcer (OR, 4.09); and for Campylobacter with cecal valve lesion (OR, 58.3) or ≥10 mm (OR, 10.4). The sensitivity of endoscopic sample collection was significantly higher than that of standard stool sample collection for the diagnosis of amebiasis, TB, non-TB mycobacteria, and other bacteria (P < .05). The methods that detected infection with the highest levels of sensitivity were biopsy with histology for amebiasis, biopsy with culture for TB, biopsy with polymerase chain reaction for cytomegalovirus, and aspiration of intestinal fluid with culture for Campylobacter. Combining results from endoscopic analysis with appropriate sample collection and pathogen detection methods enables infectious colitis to be differentiated from other noninfectious

  4. Assessment of tuberculosis spatial hotspot areas in Antananarivo, Madagascar, by combining spatial analysis and genotyping.

    Science.gov (United States)

    Ratovonirina, Noël Harijaona; Rakotosamimanana, Niaina; Razafimahatratra, Solohery Lalaina; Raherison, Mamy Serge; Refrégier, Guislaine; Sola, Christophe; Rakotomanana, Fanjasoa; Rasolofo Razanamparany, Voahangy

    2017-08-14

    Tuberculosis (TB) remains a public health problem in Madagascar. A crucial element of TB control is the development of an easy and rapid method for the orientation of TB control strategies in the country. Our main objective was to develop a TB spatial hotspot identification method by combining spatial analysis and TB genotyping method in Antananarivo. Sputa of new pulmonary TB cases from 20 TB diagnosis and treatment centers (DTCs) in Antananarivo were collected from August 2013 to May 2014 for culture. Mycobacterium tuberculosis complex (MTBC) clinical isolates were typed by spoligotyping on a Luminex® 200 platform. All TB patients were respectively localized according to their neighborhood residence and the spatial distribution of all pulmonary TB patients and patients with genotypic clustered isolates were scanned respectively by the Kulldorff spatial scanning method for identification of significant spatial clustering. Areas exhibiting spatial clustering of patients with genotypic clustered isolates were considered as hotspot TB areas for transmission. Overall, 467 new cases were included in the study, and 394 spoligotypes were obtained (84.4%). New TB cases were distributed in 133 of the 192 Fokontany (administrative neighborhoods) of Antananarivo (1 to 15 clinical patients per Fokontany) and patients with genotypic clustered isolates were distributed in 127 of the 192 Fokontany (1 to 13 per Fokontany). A single spatial focal point of epidemics was detected when ignoring genotypic data (p = 0.039). One Fokontany of this focal point and three additional ones were detected to be spatially clustered when taking genotypes into account (p Madagascar and will allow better TB control strategies by public health authorities.

  5. Combined analysis of cell growth and apoptosis-regulating proteins in HPVs associated anogenital tumors

    International Nuclear Information System (INIS)

    Mitsuishi, Tsuyoshi; Kawana, Seiji; Ozaki, Kohji; Nakatake, Mayuka; Yamada, Osamu; Iwabu, Yukie; Tokunaga, Kenzo; Sata, Tetsutaro; Kaneko, Takehiko; Ohara, Kuniaki; Ohsawa, Ikuroh; Oda, Fumino; Yamada, Yuko

    2010-01-01

    The clinical course of human papillomavirus (HPV) associated with Bowenoid papulosis and condyloma acuminatum of anogenital tumors are still unknown. Here we evaluated molecules that are relevant to cellular proliferation and regulation of apoptosis in HPV associated anogenital tumors. We investigated the levels of telomerase activity, and inhibitor of apoptosis proteins (IAPs) family (c-IAP1, c-IAP2, XIAP) and c-Myc mRNA expression levels in 20 specimens of Bowenoid papulosis and 36 specimens of condyloma acuminatum in anogenital areas. Overall, phosphorylated (p-) AKT, p-ribosomal protein S6 (S6) and p-4E-binding protein 1 (4EBP1) expression levels were examined by immunohistochemistry in anogenital tumors both with and without positive telomerase activity. Positive telomerase activity was detected in 41.7% of Bowenoid papulosis and 27.3% of condyloma acuminatum compared to normal skin (p < 0.001). In contrast, the expression levels of Bowenoid papulosis indicated that c-IAP1, c-IAP2 and XIAP mRNA were significantly upregulated compared to those in both condyloma acuminatum samples (p < 0.001, p < 0.001, p = 0.022, respectively) and normal skin (p < 0.001, p = 0.002, p = 0.034, respectively). Overall, 30% of Bowenoid papulosis with high risk HPV strongly promoted IAPs family and c-Myc but condyloma acuminatum did not significantly activate those genes. Immunohistochemically, p-Akt and p-S6 expressions were associated with positive telomerase activity but not with p-4EBP1 expression. Combined analysis of the IAPs family, c-Myc mRNA expression, telomerase activity levels and p-Akt/p-S6 expressions may provide clinically relevant molecular markers in HPV associated anogenital tumors

  6. Regression Analysis of Combined Gene Expression Regulation in Acute Myeloid Leukemia

    Science.gov (United States)

    Li, Yue; Liang, Minggao; Zhang, Zhaolei

    2014-01-01

    Gene expression is a combinatorial function of genetic/epigenetic factors such as copy number variation (CNV), DNA methylation (DM), transcription factors (TF) occupancy, and microRNA (miRNA) post-transcriptional regulation. At the maturity of microarray/sequencing technologies, large amounts of data measuring the genome-wide signals of those factors became available from Encyclopedia of DNA Elements (ENCODE) and The Cancer Genome Atlas (TCGA). However, there is a lack of an integrative model to take full advantage of these rich yet heterogeneous data. To this end, we developed RACER (Regression Analysis of Combined Expression Regulation), which fits the mRNA expression as response using as explanatory variables, the TF data from ENCODE, and CNV, DM, miRNA expression signals from TCGA. Briefly, RACER first infers the sample-specific regulatory activities by TFs and miRNAs, which are then used as inputs to infer specific TF/miRNA-gene interactions. Such a two-stage regression framework circumvents a common difficulty in integrating ENCODE data measured in generic cell-line with the sample-specific TCGA measurements. As a case study, we integrated Acute Myeloid Leukemia (AML) data from TCGA and the related TF binding data measured in K562 from ENCODE. As a proof-of-concept, we first verified our model formalism by 10-fold cross-validation on predicting gene expression. We next evaluated RACER on recovering known regulatory interactions, and demonstrated its superior statistical power over existing methods in detecting known miRNA/TF targets. Additionally, we developed a feature selection procedure, which identified 18 regulators, whose activities clustered consistently with cytogenetic risk groups. One of the selected regulators is miR-548p, whose inferred targets were significantly enriched for leukemia-related pathway, implicating its novel role in AML pathogenesis. Moreover, survival analysis using the inferred activities identified C-Fos as a potential AML

  7. Improving archaeological site analysis: a rampart in the middle Orkhon Valley investigated with combined geoscience techniques

    International Nuclear Information System (INIS)

    Grützner, C; Bemmann, J; Reichert, S; Berking, J; Klinger, R; Frechen, M; Schütt, B; Klitzsch, N; Linzen, S; Schneider, M; Mackens, S; Oczipka, M; Piezonka, H

    2012-01-01

    The Orkhon Valley in the Central Mongolia was included in the World Heritage list in 2004. It hosts multiple archaeological sites from Palaeolithic to recent times, which can contribute to the reconstruction of settlement history in this part of the Eurasian Steppe landscape. Almost 100 archaeological sites from prehistoric and historic times including ramparts and khirigsuurs were investigated in five field campaigns from 2008 to 2010 in the middle and upper Orkhon Valley. One site, MOR-2 (Dörvölzhin), proved especially difficult to date due to the lack of sufficient archaeological surface finds, and its role within a manifold of walled enclosures from different times in the study area remained unclear. Therefore, different techniques of archaeology, geophysics and geoarchaeology were combined at MOR-2 in order to determine a comprehensive picture about its timing, archaeological meaning, and environmental history. Information on topographical setting and morphometry of the rampart was gathered by an octocopter equipped with a high-resolution range finder camera. We achieved a high-resolution DEM that allowed us to map the rampart in detail and this served as a base map for all other investigations. SQUID magnetometry, ground-penetrating radar, and electric resistivity measurements (capacitive coupled geoelectrics) were subsequently used to detect archaeological remains and to characterize the sediment distribution of the inner part of the enclosure and the ramparts themselves. The data show that the construction of the walls is similar to well-known Uighur neighbouring sites. Man-made sub-surface structures or bigger finds could not be detected. Sediment cores were drilled in a nearby meander, covering 3000 years BP. The analysis of the strata in terms of elemental composition (P, N, Mn, Fe, etc) revealed an increase of organic content in Medieval times, whereas the allochthonous filling of the back water must have started around the beginning of the 6th

  8. Mutation Analysis of Consanguineous Moroccan Patients with Parkinson’s Disease Combining Microarray and Gene Panel

    Directory of Open Access Journals (Sweden)

    Ahmed Bouhouche

    2017-10-01

    Full Text Available During the last two decades, 15 different genes have been reported to be responsible for the monogenic form of Parkinson’s disease (PD, representing a worldwide frequency of 5–10%. Among them, 10 genes have been associated with autosomal recessive PD, with PRKN and PINK1 being the most frequent. In a cohort of 145 unrelated Moroccan PD patients enrolled since 2013, 19 patients were born from a consanguineous marriage, of which 15 were isolated cases and 4 familial. One patient was homozygous for the common LRRK2 G2019S mutation and the 18 others who did not carry this mutation were screened for exon rearrangements in the PRKN gene using Affymetrix Cytoscan HD microarray. Two patients were determined homozygous for PRKN exon-deletions, while another patient presented with compound heterozygous inheritance (3/18, 17%. Two other patients showed a region of homozygosity covering the 1p36.12 locus and were sequenced for the candidate PINK1 gene, which revealed two homozygous point mutations: the known Q456X mutation in exon 7 and a novel L539F variation in exon 8. The 13 remaining patients were subjected to next-generation sequencing (NGS that targeted a panel of 22 PD-causing genes and overlapping phenotypes. NGS data showed that two unrelated consanguineous patients with juvenile-onset PD (12 and 13 years carried the same homozygous stop mutation W258X in the ATP13A2 gene, possibly resulting from a founder effect; and one patient with late onset (76 years carried a novel heterozygous frameshift mutation in SYNJ1. Clinical analysis showed that patients with the ATP13A2 mutation developed juvenile-onset PD with a severe phenotype, whereas patients having either PRKN or PINK1 mutations displayed early-onset PD with a relatively mild phenotype. By identifying pathogenic mutations in 45% (8/18 of our consanguineous Moroccan PD series, we demonstrate that the combination of chromosomal microarray analysis and NGS is a powerful approach to

  9. 15. ESRF users meeting

    Energy Technology Data Exchange (ETDEWEB)

    Fotis C, Kafatos; Ulrich, K.U.; Weib, S.; Rossberg, A.; Scheinost, A.C.; Foerstendorf, H.; Zanker, H.; Meyerheim, H.L.; Sander, D.; Popescu, R.; Kirschner, J.; Robach, O.; Ferrer, S.; Lyman, P.F.; Shneerson, V.L.; Fung, R.; Harder, R.J.; Parihar, S.S.; Johnson-Steigelman, H.T.; Lu, E.D.; Saldin, D.K.; Eastwood, D.S.; Atkinson, D.; Tanner, B.K.; Hase, T.P.A.; Van Kampen, M.; Hjorvarsson, B.; Brown, S.; Thompson, P.; Konovalov, O.; Saint-Martin, E.; Daillant, J.; Luzet, D.; Szlachetko, J.; Barrett, R.; Berset, M.; Dousse, J.C.; Fennane, K.; Hoszowska, J.; Kubala-Kukus, A.; Pajek, M.; Szlachetko, M.; Monaco, A.; Chumakov, A.; Crichton, W.; Van Buerck, I.; Wortmann, G.; Meyer, A.; Ponkratz, U.; Ruffer, R.; Sakurai, Y.; Hiraoka, N.; Itou, M.; Buslaps, T.; Honkimki, V.; Maeno, Y.; Collart, E.; Shukla, A.; Rueff, J.P.; Leininger, Ph.; Ishii, H.; Cai, Y.; Cheong, S.W.; Martins, R.M.S.; Schell, N.; Beckers, M.; Silva, R.; Braz Fernandes, F.M.; Acapito, F.; Seta, M. de; Capelini, G.; Giorgi, M.; Schorr, G.; Geandier, G.; Alves Marques, M.; Barros Marquesa, M.I. de; Cabaco, M.I.; Gaspara, A.M.; Marques, M.P.M.; Amado, A.M.; Amorim da Costa, A.M.; Bruneseaux, F.; Weisbecker, P.; Brandao, M.J.; Aeby-Gautier, E.; Simmonds, H.; Lei, C.; Das, A.; Trolley, D.; Thomas, H.E.; Macdonald, J.E.; Wiegart, L.; Tolan, M.; Struth, B.; Petukhov, A.V.; Thijssen, J.H.J.; Hart, D.C.; Imhof, A.; Van Blaaderen, A.; Dolbnya, I.P.; Snigirev, A.; Mossaid, A.; Snigireva, I.; Reconditi, M.; Brunello, E

    2005-07-01

    This document gathers the posters presented on the one day and a half long plenary meeting workshop. This meeting workshop is a privileged forum where ESRF users can exchange their views on the latest scientific and technical development involving synchrotron radiation. One poster deals with the investigation of colloid composition and uranium bond structure to see whether the migration of contaminants from abandoned mines could be stimulated or attenuated by colloids. Another poster is dedicated to the investigation of the uranium speciation in covered mine tailings by a combination of micro-spectroscopic and wet chemical approaches. 2 posters deal with the contribution of synchrotron radiation to radiotherapy.

  10. 15. ESRF users meeting

    International Nuclear Information System (INIS)

    Fotis C, Kafatos; Ulrich, K.U.; Weib, S.; Rossberg, A.; Scheinost, A.C.; Foerstendorf, H.; Zanker, H.; Meyerheim, H.L.; Sander, D.; Popescu, R.; Kirschner, J.; Robach, O.; Ferrer, S.; Lyman, P.F.; Shneerson, V.L.; Fung, R.; Harder, R.J.; Parihar, S.S.; Johnson-Steigelman, H.T.; Lu, E.D.; Saldin, D.K.; Eastwood, D.S.; Atkinson, D.; Tanner, B.K.; Hase, T.P.A.; Van Kampen, M.; Hjorvarsson, B.; Brown, S.; Thompson, P.; Konovalov, O.; Saint-Martin, E.; Daillant, J.; Luzet, D.; Szlachetko, J.; Barrett, R.; Berset, M.; Dousse, J.C.; Fennane, K.; Hoszowska, J.; Kubala-Kukus, A.; Pajek, M.; Szlachetko, M.; Monaco, A.; Chumakov, A.; Crichton, W.; Van Buerck, I.; Wortmann, G.; Meyer, A.; Ponkratz, U.; Ruffer, R.; Sakurai, Y.; Hiraoka, N.; Itou, M.; Buslaps, T.; Honkimki, V.; Maeno, Y.; Collart, E.; Shukla, A.; Rueff, J.P.; Leininger, Ph.; Ishii, H.; Cai, Y.; Cheong, S.W.; Martins, R.M.S.; Schell, N.; Beckers, M.; Silva, R.; Braz Fernandes, F.M.; Acapito, F.; Seta, M. de; Capelini, G.; Giorgi, M.; Schorr, G.; Geandier, G.; Alves Marques, M.; Barros Marquesa, M.I. de; Cabaco, M.I.; Gaspara, A.M.; Marques, M.P.M.; Amado, A.M.; Amorim da Costa, A.M.; Bruneseaux, F.; Weisbecker, P.; Brandao, M.J.; Aeby-Gautier, E.; Simmonds, H.; Lei, C.; Das, A.; Trolley, D.; Thomas, H.E.; Macdonald, J.E.; Wiegart, L.; Tolan, M.; Struth, B.; Petukhov, A.V.; Thijssen, J.H.J.; Hart, D.C.; Imhof, A.; Van Blaaderen, A.; Dolbnya, I.P.; Snigirev, A.; Mossaid, A.; Snigireva, I.; Reconditi, M.; Brunello, E.

    2005-01-01

    This document gathers the posters presented on the one day and a half long plenary meeting workshop. This meeting workshop is a privileged forum where ESRF users can exchange their views on the latest scientific and technical development involving synchrotron radiation. One poster deals with the investigation of colloid composition and uranium bond structure to see whether the migration of contaminants from abandoned mines could be stimulated or attenuated by colloids. Another poster is dedicated to the investigation of the uranium speciation in covered mine tailings by a combination of micro-spectroscopic and wet chemical approaches. 2 posters deal with the contribution of synchrotron radiation to radiotherapy

  11. [Fixed drug combinations in hypertension: a budget impact analysis for the Spanish Health System on the marketing of a fixed combination of olmesartan/amlodipine].

    Science.gov (United States)

    Belén Ferro-Rey, M; Roca-Cusachs, Alex; Sicras-Mainar, Antoni; Alvarez-Martín, Carlos; de Salas-Cansado, Marina

    2011-07-01

    To carry out a budget impact analysis (BIA) of olmesartan/amlodipine (20/5, 40/5 and 40/10mg) marketed as a fixed combination (FC) in its approved indication for the National Health System (NHS). We developed a decision tree model in order to estimate usual hypertension treatment algorithm in Spanish clinical practice. The BIA has been developed from the perspective of the NHS for a period of 3 years (years 2010-2012). Spanish hypertensive population ≥ 35 years old. Introduction into the market of a fixed combination (FC) olmesartan/amlodipine in Spain. Expected costs to be assumed by the Spanish NHS (RRP-VAT) for hypertensive population able to be treated with the FC versus currently assumed costs by the NHS with free combination olmesartan and amlodipine. Estimated pharmaceutical costs in hypertensive population treated with olmesartan and amlodipine (2 pills) would be €25.2M (1(st) year), €26.4M (2011), €27.6M (2012), with a total 3-year period of €79.2M. According to patient tree model, the population able to be treated with FC would be 71,283 patients (2010), with a growth rate of 4.8% in the successive years, which supposes an annual cost of €21.2M (2010), €21.8M (2011) and €22.4M (2012), with a total 3-year period of €65.4M. The BIA shows savings of €13.8M in a total 3-year period. The BIA of FC olmesartan/amlodipine could generate net savings of €13.8M for the NHS in the period ranging from years 2010 to 2012. Copyright © 2010 Elsevier España, S.L. All rights reserved.

  12. Analysis of polycyclic aromatic hydrocarbons in vegetable oils combining gel permeation chromatography with solid-phase extraction clean-up

    DEFF Research Database (Denmark)

    Fromberg, Arvid; Højgård, A.; Duedahl-Olesen, Lene

    2007-01-01

    system equipped with a GPC column (S-X3) and pre-packed silica SPE columns for the subsequent clean-up and finally gas chromatography-mass spectrometry (GC-MS) determination. The method was validated for the determination of PAHs in vegetable oils and it can meet the criteria for the official control...... of benzo[a]pyrene levels in foods laid down by the Commission of the European Communities. A survey of 69 vegetable oils sampled from the Danish market included olive oil as well as other vegetable oils such as rapeseed oil, sunflower oil, grape seed oil and sesame oil. Levels of benzo[a]pyrene in all......A semi-automatic method for the determination of polycyclic aromatic hydrocarbons (PAHs) in edible oils using a combined gel permeation chromatography/solid-phase extraction (GPC/SPE) clean-up is presented. The method takes advantage of automatic injections using a Gilson ASPEC XL sample handling...

  13. Meeting Mid-Year Meeting

    Indian Academy of Sciences (India)

    23 Newsletter of the Indian Academy of ScienCE. 57th Annual. Meeting ... Srinivas, Institute for Social and Economic. Change ... "Quantum mechanics and statistical mechanics of anyons" .... Special Issue on Geomagnetic Methods and.

  14. The Efficacy of Synchronous Combination of Chemotherapy and EGFR TKIs for the First-Line Treatment of NSCLC: A Systematic Analysis.

    Directory of Open Access Journals (Sweden)

    Han Yan

    Full Text Available The combination of chemotherapy and epidermal growth factor receptor (EGFR tyrosine kinase inhibitors (TKIs currently has become the hotspot issue in the treatment of non-small lung cancer (NSCLC. This systematic review was conducted to compare the efficacy and safety of the synchronous combination of these two treatments with EGFR TKIs or chemotherapy alone in advanced NSCLC.EMBASE, PubMed, the Central Registry of Controlled Trials in the Cochrane Library (CENTRAL, Chinese biomedical literature database (CNKI and meeting summaries were searched. The Phase II/III randomized controlled trials were selected by which patients with advanced NSCLC were randomized to receive a combination of EGFR TKIs and chemotherapy by synchronous mode vs. EGFR TKIs or chemotherapy alone.A total of six randomized controlled trials (RCTs including 4675 patients were enrolled in the systematic review. The meta-analysis demonstrated that the synchronous combination group of chemotherapy and EGFR TKIs did not reach satisfactory results; there was no significant difference in overall survival (OS, time to progression (TTP and objective response rate (ORR, compared with monotherapy (OS: HR = 1.05, 95%CI = 0.98-1.12; TTP: HR = 0.94, 95%CI = 0.89-1.00; ORR: RR = 1.07, 95%CI = 0.98-1.17, and no significant difference in OS and progression-free survival (PFS, compared with EGFR TKIs alone (OS: HR = 1.10, 95% CI = 0.83-1.46; PFS: HR = 0.86, 95% CI = 0.67-1.10. The patients who received synchronous combined therapy presented with increased incidences of grade 3/4 anemia (RR = 1.40, 95% CI = 1.10-1.79 and rash (RR = 7.43, 95% CI = 4.56-12.09, compared with chemotherapy, grade 3/4 anemia (RR = 6.71, 95% CI = 1.25-35.93 and fatigue (RR = 9.60, 95% CI = 2.28-40.86 compared with EGFR TKI monotherapy.The synchronous combination of chemotherapy and TKIs is not superior to chemotherapy or EGFR TKIs alone for the first-line treatment of NSCLC.

  15. Ex vivo analysis identifies effective HIV-1 latency–reversing drug combinations

    Science.gov (United States)

    Laird, Gregory M.; Bullen, C. Korin; Rosenbloom, Daniel I.S.; Martin, Alyssa R.; Hill, Alison L.; Durand, Christine M.; Siliciano, Janet D.; Siliciano, Robert F.

    2015-01-01

    Reversal of HIV-1 latency by small molecules is a potential cure strategy. This approach will likely require effective drug combinations to achieve high levels of latency reversal. Using resting CD4+ T cells (rCD4s) from infected individuals, we developed an experimental and theoretical framework to identify effective latency-reversing agent (LRA) combinations. Utilizing ex vivo assays for intracellular HIV-1 mRNA and virion production, we compared 2-drug combinations of leading candidate LRAs and identified multiple combinations that effectively reverse latency. We showed that protein kinase C agonists in combination with bromodomain inhibitor JQ1 or histone deacetylase inhibitors robustly induce HIV-1 transcription and virus production when directly compared with maximum reactivation by T cell activation. Using the Bliss independence model to quantitate combined drug effects, we demonstrated that these combinations synergize to induce HIV-1 transcription. This robust latency reversal occurred without release of proinflammatory cytokines by rCD4s. To extend the clinical utility of our findings, we applied a mathematical model that estimates in vivo changes in plasma HIV-1 RNA from ex vivo measurements of virus production. Our study reconciles diverse findings from previous studies, establishes a quantitative experimental approach to evaluate combinatorial LRA efficacy, and presents a model to predict in vivo responses to LRAs. PMID:25822022

  16. Analysis of the publication rate of the abstracts presented at a national gastroenterology meeting after 6 years

    Science.gov (United States)

    Gandhi, Divyangkumar; Mclean, Richard W.; Laiyemo, Adeyinka O.

    2017-01-01

    Background/Aims Abstract presentations at scientific meetings provide an opportunity to convey the results of important research. Unfortunately, many abstracts are not eventually published as full manuscripts. We evaluated factors associated with publication of abstracts as manuscripts up to 6.5 years after presentation at the 73rd scientific meeting of the American College of Gastroenterology in 2008. Methods All abstracts, excluding case reports, presented at the meeting were evaluated. We systematically searched for matching manuscripts indexed in PubMed or EMBASE up till May 2015. We used logistic regression models to determine factors associated with manuscript publication and calculated odds ratios (OR) and 95% confidence intervals (CI). Results Of included 791 abstracts, 249 (31.5%) were published as manuscripts within 6.5 years. Oral presentation (OR=2.11; 95%CI: 1.15-3.87), multicenter studies (OR=2.67; 95%CI: 1.44-4.95), abstracts by University-based authors (OR=1.80; 95%CI: 1.20-2.72), and funded research (OR=2.15; 95%CI: 1.43-3.23) were more likely to be published. Winning an award at the meeting was not associated with manuscript publication (OR=1.09; 95%CI: 0.57-2.06). Conclusions There is an urgent need to improve dissemination of scientific knowledge through publication of abstracts presented at gastroenterology meetings as manuscripts. Mentors should endeavor to encourage their mentees to complete this final stage of their scholarly activities. PMID:27931019

  17. Technical Analysis of Installed Micro-Combined Heat and Power Fuel-Cell System

    Energy Technology Data Exchange (ETDEWEB)

    Brooks, Kriston P.; Makhmalbaf, Atefe

    2014-10-31

    Combined heat and power fuel cell systems (CHP-FCSs) provide consistent electrical power and hot water with greater efficiency and lower emissions than alternative sources. These systems can be used either as baseload, grid-connected, or as off-the-grid power sources. This report presents a technical analysis of 5 kWe CHP-FCSs installed in different locations in the U.S. At some sites as many as five 5 kWe system is used to provide up to 25kWe of power. Systems in this power range are considered “micro”-CHP-FCS. To better assess performance of micro-CHP-FCS and understand their benefits, the U.S. Department of Energy worked with ClearEdge Power to install fifteen 5-kWe PBI high temperature PEM fuel cells (CE5 models) in the commercial markets of California and Oregon. Pacific Northwest National Laboratory evaluated these systems in terms of their economics, operations, and technical performance. These units were monitored from September 2011 until June 2013. During this time, about 190,000 hours of data were collected and more than 17 billion data points were analyzed. Beginning in July 2013, ten of these systems were gradually replaced with ungraded systems (M5 models) containing phosphoric acid fuel cell technology. The new units were monitored until June 2014 until they went offline because ClearEdge was bought by Doosan at the time and the new manufacturer did not continue to support data collection and maintenance of these units. During these two phases, data was collected at once per second and data analysis techniques were applied to understand behavior of these systems. The results of this analysis indicate that systems installed in the second phase of this demonstration performed much better in terms of availability, consistency in generation, and reliability. The average net electrical power output increased from 4.1 to 4.9 kWe, net heat recovery from 4.7 to 5.4 kWth, and system availability improved from 94% to 95%. The average net system electric

  18. Preliminary identification of unicellular algal genus by using combined confocal resonance Raman spectroscopy with PCA and DPLS analysis

    Science.gov (United States)

    He, Shixuan; Xie, Wanyi; Zhang, Ping; Fang, Shaoxi; Li, Zhe; Tang, Peng; Gao, Xia; Guo, Jinsong; Tlili, Chaker; Wang, Deqiang

    2018-02-01

    The analysis of algae and dominant alga plays important roles in ecological and environmental fields since it can be used to forecast water bloom and control its potential deleterious effects. Herein, we combine in vivo confocal resonance Raman spectroscopy with multivariate analysis methods to preliminary identify the three algal genera in water blooms at unicellular scale. Statistical analysis of characteristic Raman peaks demonstrates that certain shifts and different normalized intensities, resulting from composition of different carotenoids, exist in Raman spectra of three algal cells. Principal component analysis (PCA) scores and corresponding loading weights show some differences from Raman spectral characteristics which are caused by vibrations of carotenoids in unicellular algae. Then, discriminant partial least squares (DPLS) classification method is used to verify the effectiveness of algal identification with confocal resonance Raman spectroscopy. Our results show that confocal resonance Raman spectroscopy combined with PCA and DPLS could handle the preliminary identification of dominant alga for forecasting and controlling of water blooms.

  19. Laser-induced breakdown spectroscopy applied to the characterization of rock by support vector machine combined with principal component analysis

    International Nuclear Information System (INIS)

    Yang Hong-Xing; Fu Hong-Bo; Wang Hua-Dong; Jia Jun-Wei; Dong Feng-Zhong; Sigrist, Markus W

    2016-01-01

    Laser-induced breakdown spectroscopy (LIBS) is a versatile tool for both qualitative and quantitative analysis. In this paper, LIBS combined with principal component analysis (PCA) and support vector machine (SVM) is applied to rock analysis. Fourteen emission lines including Fe, Mg, Ca, Al, Si, and Ti are selected as analysis lines. A good accuracy (91.38% for the real rock) is achieved by using SVM to analyze the spectroscopic peak area data which are processed by PCA. It can not only reduce the noise and dimensionality which contributes to improving the efficiency of the program, but also solve the problem of linear inseparability by combining PCA and SVM. By this method, the ability of LIBS to classify rock is validated. (paper)

  20. An isoeffect approach to the study of combined effects of mixed radiations--the nonparametric analysis of in vivo data

    International Nuclear Information System (INIS)

    Lam, G.K.

    1989-01-01

    The combined effects of mixed radiations can be examined using a system of simple isoeffect relations which are derived from a recent analysis of in vitro results obtained for a variety of radiation mixtures. Similar isoeffect analysis methods have been used for over two decades in studies of the combined action of toxic agents such as drugs and antibiotics. Because of the isoeffect approach, the method is particularly useful for the analysis of ordinal data for which conventional models that are based on parametric dose-effect relations may not be suitable. This is illustrated by applying the method to the analysis of a set of recently published in vivo data using the mouse foot skin reaction system for mixtures of neutrons and X rays. The good agreement between this method and the ordinal data also helps to provide further experimental support for the existence of a class of radiobiological data for which the simple isoeffect relations are valid

  1. Combination of pharmacotherapy and psychotherapy in the treatment of chronic depression: A systematic review and meta-analysis

    Science.gov (United States)

    2012-01-01

    Background Chronic depression represents a substantial portion of depressive disorders and is associated with severe consequences. This review examined whether the combination of pharmacological treatments and psychotherapy is associated with higher effectiveness than pharmacotherapy alone via meta-analysis; and identified possible treatment effect modifiers via meta-regression-analysis. Methods A systematic search was conducted in the following databases: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, ISI Web of Science, BIOSIS, PsycINFO, and CINAHL. Primary efficacy outcome was a response to treatment; primary acceptance outcome was dropping out of the study. Only randomized controlled trials were considered. Results We identified 8 studies with a total of 9 relevant comparisons. Our analysis revealed small, but statistically not significant effects of combined therapies on outcomes directly related to depression (BR = 1.20) with substantial heterogeneity between studies (I² = 67%). Three treatment effect modifiers were identified: target disorders, the type of psychotherapy and the type of pharmacotherapy. Small but statistically significant effects of combined therapies on quality of life (SMD = 0.18) were revealed. No differences in acceptance rates and the long-term effects between combined treatments and pure pharmacological interventions were observed. Conclusions This systematic review could not provide clear evidence for the combination of pharmacotherapy and psychotherapy. However, due to the small amount of primary studies further research is needed for a conclusive decision. PMID:22694751

  2. Combined EGFR and VEGFR versus single EGFR signaling pathways inhibition therapy for NSCLC: a systematic review and meta-analysis.

    Directory of Open Access Journals (Sweden)

    Xinji Zhang

    Full Text Available BACKGROUND: Lung cancer is a heterogeneous disease with multiple signaling pathways influencing tumor cell survival and proliferation, and it is likely that blocking only one of these pathways allows others to act as salvage or escape mechanisms for cancer cells. Whether combined inhibition therapy has greater anti-tumor activity than single inhibition therapy is a matter of debate. Hence, a meta-analysis comparing therapy inhibiting both VEGFR and EGFR signaling pathways with that inhibiting EGFR signaling pathway alone was performed. METHODOLOGY AND PRINCIPAL FINDINGS: We searched PubMed, EMBASE database and the proceedings of major conferences for relevant clinical trials. Outcomes analyzed were objective tumor response rate (ORR, progression-free survival (PFS, overall survival (OS and toxicity. Besides, subgroup analyses were performed to investigate whether the combined inhibition therapy is best performed using combination of selective agents or a single agent with multiple targets. Six trials recruiting 3,302 patients were included in the analysis. Combined inhibition therapy was associated with a 3% improvement in OS as compared with single-targeted therapy, but this difference was not statistically significant (HR, 0.97; 95% CI, 0.89-1.05; P=0.472. Patients receiving combined inhibition therapy had significant longer PFS than the group with single-targeted therapy (HR, 0.80; 95% CI, 0.67-0.95; P=0.011. There was no difference in the ORR between the groups (OR, 1.44; 95% CI, 0.95-2.18; P=0.085. Subgroup analysis revealed that combined inhibition therapy using combination regimens was associated with statistically significant improvement in both ORR and PFS. Toxicity was greater in combined inhibition therapy. CONCLUSIONS: There is no evidence to support the use of combined inhibition therapy in unselected patients with advanced NSCLC. However, given the significant advantage in ORR and PFS, combined inhibition therapy using combination

  3. Selection Component Analysis of Natural Polymorphisms using Population Samples Including Mother-Offspring Combinations, II

    DEFF Research Database (Denmark)

    Jarmer, Hanne Østergaard; Christiansen, Freddy Bugge

    1981-01-01

    Population samples including mother-offspring combinations provide information on the selection components: zygotic selection, sexual selection, gametic seletion and fecundity selection, on the mating pattern, and on the deviation from linkage equilibrium among the loci studied. The theory...

  4. THERMODYNAMIC ANALYSIS AND SIMULATION OF A NEW COMBINED POWER AND REFRIGERATION CYCLE USING ARTIFICIAL NEURAL NETWORK

    Directory of Open Access Journals (Sweden)

    Hossein Rezvantalab

    2011-01-01

    Full Text Available In this study, a new combined power and refrigeration cycle is proposed, which combines the Rankine and absorption refrigeration cycles. Using a binary ammonia-water mixture as the working fluid, this combined cycle produces both power and refrigeration output simultaneously by employing only one external heat source. In order to achieve the highest possible exergy efficiency, a secondary turbine is inserted to expand the hot weak solution leaving the boiler. Moreover, an artificial neural network (ANN is used to simulate the thermodynamic properties and the relationship between the input thermodynamic variables on the cycle performance. It is shown that turbine inlet pressure, as well as heat source and refrigeration temperatures have significant effects on the net power output, refrigeration output and exergy efficiency of the combined cycle. In addition, the results of ANN are in excellent agreement with the mathematical simulation and cover a wider range for evaluation of cycle performance.

  5. Performance analysis of joint diversity combining, adaptive modulation, and power control schemes

    KAUST Repository

    Qaraqe, Khalid A.; Bouida, Zied; Alouini, Mohamed-Slim

    2011-01-01

    Adaptive modulation and diversity combining represent very important adaptive solutions for future generations of wireless communication systems. Indeed, in order to improve the performance and the efficiency of these systems, these two techniques

  6. Identification of drug combinations administered by continuous subcutaneous infusion that require analysis for compatibility and stability

    OpenAIRE

    Dickman, Andrew; Bickerstaff, Matthew; Jackson, Richard; Schneider, Jennifer; Mason, Stephen; Ellershaw, John

    2017-01-01

    Background A continuous subcutaneous infusion (CSCI) delivered via syringe pump is a method of drug administration used to maintain symptom control when a patient is no longer able to tolerate oral medication. Several classes of drugs, such as opioids, antiemetics, anticholinergics, antipsychotics and benzodiazepines are routinely administered by CSCI alone or in combinations. Previous studies attempting to identify the most-common CSCI combinations are now several years old and no longer ref...

  7. Analysis of the location for peak heating in CHP based combined district heating systems

    International Nuclear Information System (INIS)

    Wang, Haichao; Lahdelma, Risto; Wang, Xin; Jiao, Wenling; Zhu, Chuanzhi; Zou, Pinghua

    2015-01-01

    Combined heat and power (CHP) is the main technology for providing the base load of district heating in China. However, CHP is not efficient for providing the peak load; instead, a peak boiler with high efficiency could be used to compensate the peak load. This paper studies how the location of the peak boiler can affect the energy efficiency and economic performance of such CHP based combined district heating system. Firstly, the connection mode and the control strategy for different peak heating locations are analyzed. Then the effect of the peak boiler's location on the initial investment of the network and the cost for distributing heat is studied. The objective is to place the peak boiler in a location where the overall costs are the smallest. Following this rule, the results indicate that the peak boiler should be located at the CHP plant if that allows using cheaper ‘self-use electricity’ in CHP for distributing the heat. However, if the market electricity price is used everywhere, or if energy efficiency is more emphasized, the location of the peak boiler should be closer to the users with dense heat loads. - Highlights: • Location for peak heating in the CHP based combined DH system is studied. • Regulation or control strategies for combined DH are summarized. • The heat load duration curve for combined DH is demonstrated. • Network design for combined DH with peak boiler outside of the CHP is analyzed

  8. An Analysis Of The Benefits And Application Of Earned Value Management (EVM) Project Management Techniques For Dod Programs That Do Not Meet Dod Policy Thresholds

    Science.gov (United States)

    2017-12-01

    VALUE MANAGEMENT (EVM) PROJECT MANAGEMENT TECHNIQUES FOR DOD PROGRAMS THAT DO NOT MEET DOD POLICY THRESHOLDS December 2017 By: Randy Schneider...Joint applied project 4. TITLE AND SUBTITLE AN ANALYSIS OF THE BENEFITS AND APPLICATION OF EARNED VALUE MANAGEMENT (EVM) PROJECT MANAGEMENT ...performance reporting. The immediate objective of this research project was to examine the question: Can the application of EVM-Lite project management

  9. Public meeting

    CERN Multimedia

    HR Department

    2010-01-01

    Dear Colleagues, I am pleased to invite you to a public meeting which will be held on Thursday 11 November 2010 at 2:30 p.m., in the Main Auditorium (welcome coffee from 2 p.m.) In this meeting Sigurd Lettow, Director for Administration and General Infrastructure will present the Management’s proposals towards restoring full funding of the Pension Fund. The meeting will follow discussions which took place with the Staff Association, at the Standing Concertation Committee (CCP) of 1 November 2010 and will be held with the Members States, at the Tripartite Employment Conditions Forum (TREF) of 4 November 2010. You will be able to attend this presentation in the Main Auditorium or via the webcast. The Management will also be available to reply to your questions on this subject. Best regards, Anne-Sylvie Catherin

  10. ACCU Meeting

    CERN Multimedia

    PH Department

    2010-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 8 December 2010 at 9:15 a.m. in room 60-6-002 Chairperson's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Report on services from GS department The CERN Ombuds The new account management system Crèche progress + Restaurants Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 12 is invited to send them to the Chairperson in writing or by e-mail to Michael.Hauschild@cern.ch   Michael Hauschild (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): ...

  11. ACCU Meeting

    CERN Multimedia

    PH Department

    2011-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 9 March 2011 At 9:15 a.m. in room 60-6-002   Chairperson's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Report on services from GS department Update on Safety at CERN The new account management system Users’ Office news Any Other Business Agenda for the next meeting   Anyone wishing to raise any points under item 10 is invited to send them to the Chairperson in writing or by e-mail to Michael.Hauschild@cern.ch Michael Hauschild (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria G. Walzel (76592) Belgium ...

  12. ACCU MEETING

    CERN Multimedia

    PH Department

    2010-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 8 September 2010 at 9:15 a.m. in Room 60-6-002 Chairperson’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Report on services from GS Department An update on Safety at CERN The CERN Summer Student program Bringing Library services to users Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 12 is invited to send them to the Chairperson in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): ...

  13. ACCU Meeting

    CERN Multimedia

    PH Department

    2010-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 9 June 2010 At 9:15 a.m. in room 60-6-002 Chairperson’s remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Report on services from GS department CERN Global Network An update on Safety at CERN Reports from ACCU representatives on other committees Users’ Office news Any Other Business Agenda for the next meeting Anyone wishing to raise any points under item 11 is invited to send them to the Chairperson in writing or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria G. Walzel (76592) ...

  14. Dietary Intake, FTO Genetic Variants, and Adiposity : A Combined Analysis of Over 16,000 Children and Adolescents

    NARCIS (Netherlands)

    Qi, Qibin; Downer, Mary K.; Kilpelaeinen, Tuomas O.; Taal, H. Rob; Barton, Sheila J.; Ntalla, Ioanna; Standl, Marie; Boraska, Vesna; Huikari, Ville; Kiefte-de Jong, Jessica C.; Koerner, Antje; Lakka, Timo A.; Liu, Gaifen; Magnusson, Jessica; Okuda, Masayuki; Raitakari, Olli; Richmond, Rebecca; Scott, Robert A.; Bailey, Mark E. S.; Scheuermann, Kathrin; Holloway, John W.; Inskip, Hazel; Isasi, Carmen R.; Mossavar-Rahmani, Yasmin; Jaddoe, Vincent W. V.; Laitinen, Jaana; Lindi, Virpi; Melen, Erik; Pitsiladis, Yannis; Pitkaenen, Niina; Snieder, Harold; Heinrich, Joachim; Timpson, Nicholas J.; Wang, Tao; Yuji, Hinoda; Zeggini, Eleftheria; Dedoussis, George V.; Kaplan, Robert C.; Wylie-Rosett, Judith; Loos, Ruth J. F.; Hu, Frank B.; Qi, Lu

    The FTO gene harbors variation with the strongest effect on adiposity and obesity risk. Previous data support a role for FTO variation in influencing food intake. We conducted a combined analysis of 16,094 boys and girls aged 1-18 years from 14 studies to examine the following: 1) the association

  15. [Curative effect analysis of bile reinfusion combined with enteral nutrition support before surgery of hilar cholangiocarcinoma].

    Science.gov (United States)

    Song, P; Mao, L; Bian, X J; Zhou, T; Fan, Y Y; Zhang, J; Xie, M; Qiu, Y D

    2018-05-01

    Objective: To investigate the clinical effect of bile reinfusion combined with enteral nutrition support before surgery for hilar cholangiocarcinoma. Methods: A retrospective analysis of patients with hilar cholangiocarcinoma who underwent surgical treatment at Nanjing Drum Tower Hospital Hepato-biliary-pancreatic Surgery Department from July 2010 to August 2017 was completed.A total of 52 cases were finally enrolled in our study.All the patients included, on the basis of whether they received preoperative drainage and bile reinfusion, were divided into non-drainage group( n =15) and drainage group( n =37). Differences of clinical indicators, including operation time, intraoperative bleeding and serum liver function index levels at day 1, 3, 7 postoperative, postoperative complications(liver failure, biliary fistula, pleural effusion, peritoneal effusion, abdominal cavity infection, death in hospital), tumor classification, R0 resection, postoperative hospitalization time between the 2 groups were analyzed. At the same time, in the drainage group, patients were divided into non-enteral nutrition subgroup( n =13) and enteral nutrition subgroup( n =24) according to whether they received enteral nutrition before operation. The normal distribution data of the group was statistically analyzed by independent sample t test, the non-normal distribution data of the group was statistically analyzed by rank-sum test. The count data was statistically analyzed by non-calibration and correction of the square test. Results: There was no statistically significant difference in general infomation such as age, gender, and serum liver function between non-drainage group and drainage group( P >0.05). There was no statistically significant difference in general information such as age, gender, and serum liver function between non-enteral nutrition group and enteral nutrition group( P >0.05). The rate of vascular resection and reconstruction(33.3%) and operating time(10.8(2.2)h) in

  16. Combining groundwater quality analysis and a numerical flow simulation for spatially establishing utilization strategies for groundwater and surface water in the Pingtung Plain

    Science.gov (United States)

    Jang, Cheng-Shin; Chen, Ching-Fang; Liang, Ching-Ping; Chen, Jui-Sheng

    2016-02-01

    Overexploitation of groundwater is a common problem in the Pingtung Plain area of Taiwan, resulting in substantial drawdown of groundwater levels as well as the occurrence of severe seawater intrusion and land subsidence. Measures need to be taken to preserve these valuable groundwater resources. This study seeks to spatially determine the most suitable locations for the use of surface water on this plain instead of extracting groundwater for drinking, irrigation, and aquaculture purposes based on information obtained by combining groundwater quality analysis and a numerical flow simulation assuming the planning of manmade lakes and reservoirs to the increase of water supply. The multivariate indicator kriging method is first used to estimate occurrence probabilities, and to rank townships as suitable or unsuitable for groundwater utilization according to water quality standards for drinking, irrigation, and aquaculture. A numerical model of groundwater flow (MODFLOW) is adopted to quantify the recovery of groundwater levels in townships after model calibration when groundwater for drinking and agricultural demands has been replaced by surface water. Finally, townships with poor groundwater quality and significant increases in groundwater levels in the Pingtung Plain are prioritized for the groundwater conservation planning based on the combined assessment of groundwater quality and quantity. The results of this study indicate that the integration of groundwater quality analysis and the numerical flow simulation is capable of establishing sound strategies for joint groundwater and surface water use. Six southeastern townships are found to be suitable locations for replacing groundwater with surface water from manmade lakes or reservoirs to meet drinking, irrigation, and aquaculture demands.

  17. Staff meeting

    CERN Document Server

    2006-01-01

    I would like to invite all members of the CERN Personnel to a meeting on Thursday 18 January 2007 at 3:00 p.m. Main Auditorium (bldg.. 500) to convey my best wishes for the new year, to review CERN's activities during 2006 and to present the perspectives for this special year of the LHC start-up. Closed-circuit transmission of the meeting will be available in the Council Chamber and in the AB Auditorium (Meyrin), the AB Auditorium (Prévessin), the IT Auditorium (bldg.. 31) and the AT Auditorium (bldg.. 30). Simultaneous translation into English will be available in the main Auditorium. Robert AYMAR

  18. Scientific meetings

    International Nuclear Information System (INIS)

    1973-01-01

    One of the main aims of the IAEA is to foster the exchange of scientific and technical information and one of the main ways of doing this is to convene international scientific meetings. They range from large international conferences bringing together several hundred scientists, smaller symposia attended by an average of 150 to 250 participants and seminars designed to instruct rather than inform, to smaller panels and study groups of 10 to 30 experts brought together to advise on a particular programme or to develop a set of regulations. The topics of these meetings cover every part of the Agency's activities and form a backbone of many of its programmes. (author)

  19. STAFF MEETING

    CERN Multimedia

    Robert Aymar

    2005-01-01

    I would like to invite all members of the CERN Personnel to a meeting on Thursday 12 January 2006 at 4:00 p.m. - Main Auditorium (bldg. 500) to convey my best wishes for the new year, to review CERN's activities during 2005 and to present the perspectives for this coming year. Closed-circuit transmission of the meeting will be available in the Council Chamber and in the AB Auditorium (Meyrin), the AB Auditorium (Prévessin), the IT Auditorium (bldg. 31) and the AT Auditorium (bldg. 30). A simultaneous translation into English will be available in the main Auditorium. Best wishes for the festive season Robert AYMAR

  20. STAFF MEETING

    CERN Multimedia

    2004-01-01

    I would like to invite all members of the CERN Personnel to a meeting on Tuesday 13 January 2004 at 4:00 p.m. - Main Auditorium (bldg. 500) to convey my best wishes for the new year and to present a perspective of CERN's future activities. Closed-circuit transmission of the meeting will be available in the Council Chamber and in the AB Auditorium (Meyrin), the AB Auditorium (Prévessin), the IT Auditorium (bldg. 31) and the AT Auditorium (bldg. 30). A simultaneous translation into English will be available in the main Auditorium. Robert AYMAR

  1. Public meetings

    CERN Multimedia

    Staff Association

    2014-01-01

      Public meetings : Come and talk about your future employment conditions !   The Staff Association will come and present the results of our survey on the 2015 five-yearly review. Following the survey, the topics discussed, will be contract policy, recognition of merit (MARS), working time arrangements and family policy. After each meeting and around a cup of coffee or tea you will be able to continue the discussions. Do not hesitate to join us, the five-yearly review, it is with YOU!

  2. Performance analysis of joint diversity combining, adaptive modulation, and power control schemes

    KAUST Repository

    Qaraqe, Khalid A.

    2011-01-01

    Adaptive modulation and diversity combining represent very important adaptive solutions for future generations of wireless communication systems. Indeed, in order to improve the performance and the efficiency of these systems, these two techniques have been recently used jointly in new schemes named joint adaptive modulation and diversity combining (JAMDC) schemes. Considering the problem of finding low hardware complexity, bandwidth-efficient, and processing-power efficient transmission schemes for a downlink scenario and capitalizing on some of these recently proposed JAMDC schemes, we propose and analyze in this paper three joint adaptive modulation, diversity combining, and power control (JAMDCPC) schemes where a constant-power variable-rate adaptive modulation technique is used with an adaptive diversity combining scheme and a common power control process. More specifically, the modulation constellation size, the number of combined diversity paths, and the needed power level are jointly determined to achieve the highest spectral efficiency with the lowest possible processing power consumption quantified in terms of the average number of combined paths, given the fading channel conditions and the required bit error rate (BER) performance. In this paper, the performance of these three JAMDCPC schemes is analyzed in terms of their spectral efficiency, processing power consumption, and error-rate performance. Selected numerical examples show that these schemes considerably increase the spectral efficiency of the existing JAMDC schemes with a slight increase in the average number of combined paths for the low signal-to-noise ratio range while maintaining compliance with the BER performance and a low radiated power which yields to a substantial decrease in interference to co-existing users and systems. © 2011 IEEE.

  3. Research on combination forecast of port cargo throughput based on time series and causality analysis

    Directory of Open Access Journals (Sweden)

    Chi Zhang

    2013-03-01

    Full Text Available Purpose: The purpose of this paper is to develop a combined model composed of grey-forecast model and Logistic-growth-curve model to improve the accuracy of forecast model of cargo throughput for the port. The authors also use the existing data of a current port to verify the validity of the combined model.Design/methodology/approach: A literature review is undertaken to find the appropriate forecast model of cargo throughput for the port. Through researching the related forecast model, the authors put together the individual models which are significant to study further. Finally, the authors combine two individual models (grey-forecast model and Logistic-growth-curve model into one combined model to forecast the port cargo throughput, and use the model to a physical port in China to testify the validity of the model.Findings: Test by the perceptional data of cargo throughput in the physical port, the results show that the combined model can obtain relatively higher forecast accuracy when it is not easy to find more information. Furthermore, the forecast made by the combined model are more accurate than any of the individual ones.Research limitations/implications: The study provided a new combined forecast model of cargo throughput with a relatively less information to improve the accuracy rate of the forecast. The limitation of the model is that it requires the cargo throughput of the port have an S-shaped change trend.Practical implications: This model is not limited by external conditions such as geographical, cultural. This model predicted the port cargo throughput of one real port in China in 2015, which provided some instructive guidance for the port development.Originality/value: This is the one of the study to improve the accuracy rate of the cargo throughput forecast with little information.

  4. First Paleomagnetic Map of the Easternmost Mediterranean Derived from Combined Geophysical-Geological Analysis

    Science.gov (United States)

    Eppelbaum, Lev; Katz, Youri

    2014-05-01

    he easternmost Mediterranean is a tectonically complex region evolving in the long term and located in the midst of the progressive Afro-Eurasian collision (e.g., Ben-Avraham, 1978; Khain, 1984). Both rift-oceanic systems and terrane belts are known to have been formed in this collision zone (Stampfli et al., 2013). Despite years of investigation, the geological-geophysical structure of the easternmost Mediterranean is not completely known. The formation of its modern complex structure is associated with the evolution of the Neotethys Ocean and its margins (e.g., Ben-Avraham and Ginzburg, 1990; Robertson et al., 1991; Ben-Avraham et al., 2002). The easternmost Mediterranean was formed during the initial phase of the Neotethys in the Early and Late Permian (Golonka and Ford, 2000; Stampfli et al., 2013). At present this block of the ocean crust situated in the northern part of the Sinai plate (Ben-Avraham, 1978; Eppelbaum et al., 2012, 2014) is object of our investigation. The easternmost Mediterranean region has attracted increasing attention in connection with the recent discoveries of significant hydrocarbon deposits in this region (e.g., Montadert et al., 2010; Schenk et al., 2010; Eppelbaum et al., 2012). For example, Schenk et al. (2010) consider that more than 4 trillion m3 of recoverable gas is available in the Levant Basin (which located in the central part of the easternmost Mediterranean). Currently seismic prospecting is the main tool used in hydrocarbon deposit discovery. However, even sophisticated seismic data analysis (e.g., Hall et al., 2005; Roberts and Peace, 2007; Gardosh et al., 2010; Marlow et al., 2011; Lazar et al., 2012), fails to identify the full complex structural-tectonic mosaic of this region, and more importantly, is unable to clarify its baffling complex tectonic evolution. This highlights the need for combined analysis of geophysical data associated with the paleomagnetic and paleobiogeographic conditions that can yield deep

  5. Combination therapy versus gemcitabine monotherapy in the treatment of elderly pancreatic cancer: a meta-analysis of randomized controlled trials

    Directory of Open Access Journals (Sweden)

    Jin JM

    2018-03-01

    Full Text Available Jiamin Jin, Chunbo Teng, Tao Li College of Life Science, Northeast Forestry University, Harbin, China Purpose: We aimed to compare the efficacy of combination therapy versus gemcitabine monotherapy in the treatment of elderly pancreatic cancer (PC by using a meta-analysis.Materials and methods: Databases were searched to identify relevant clinical trials. Hazard ratios (HRs were used to estimate overall survival (OS and progression-free survival (PFS. Statistical analyses were conducted by using Comprehensive Meta Analysis software (version 2.0.Results: A total of 3,401 elderly PC patients from six randomized controlled trials were included for analysis. In comparison with gemcitabine alone, combination therapy in elderly PC patients did not significantly improve OS (HR 0.93, 95% CI: 0.82–1.06, p=0.29. Sub-group analysis according to treatment regimens showed that combined chemotherapy significantly improved OS in comparison with gemcitabine alone (HR 0.73, 95% CI: 0.56–0.94, p=0.016, while gemcitabine plus targeted agents did not improve OS (HR 1.02, 95% CI: 0.87–1.19, p=0.83. Additionally, gemcitabine plus nab-paclitaxel significantly improved PFS in elderly PC patients (HR 0.69, 95% CI: 0.52–0.91, p=0.009 in comparison with gemcitabine alone. No publication bias was detected by Begg’s and Egger’s tests for OS.Conclusion: The findings of this study suggest that combined chemotherapy, but not for gemcitabine plus targeted agents, could be recommended for elderly PC patients due to its survival benefits. Further studies are still needed to assess the treatment tolerance of combination chemotherapy in these patient populations. Keywords: pancreatic cancer, elderly, randomized controlled trials, meta-analysis, targeted agents

  6. Isotopic and other techniques for organic micronutrient analysis and development of quality assurance procedures. Report of a consultants meeting

    International Nuclear Information System (INIS)

    2001-01-01

    The Nutritional and Health Related Environmental Studies Section (NAHRES), Division of Human Health at the IAEA has been very active in supporting activities related to measurement problems of both organic and inorganic nutrients faced by several developing countries. In preparation of a systematic approach to help the needy developing countries, a new initiative under 'Nutritional Metrology in Practice' has been initiated for the years 2002 and 2003. As a first step, a small group of consultants was sought to advice the Agency on the current methodological status related to nutrient measurements. The consultants who participated in the meeting were: Dr. Katherine E. Sharpless, Dr. Paul M. Finglas, Dr. Clive West and Dr. Tee E. Siong. Recognizing the double burden of under- and overnutrition in developing countries, the following nutrients were selected as priority under the Nutritional Metrology program: vitamin A and carotenoids, folate, vitamins B 1 , B 2 , B 6 , and B 12 . The capabilities for the analyses of these nutrients in foods and serum vary extensively among the developing countries. This refers to availability of expertise, equipment, and quality control programs in these countries. Of particular interest to the Agency is the use of isotopic methods to measure these nutrients since several nutritional monitoring programmes are likely to seek this technology for future projects supported by the IAEA. There is therefore an urgent need for enhancing capabilities in these countries. This group of experts assessed the current status of quality assurance programs, training and quality control materials available for measurement of vitamin A and Beta-carotene, folate, vitamin B 1 , B 2 , B 6 and vitamin B 12 in food/serum/plasma and made their recommendations for future work in these areas: (i) extend/establish quality assurance programs for vitamin A/carotenoids and folate for food and blood analyses in developing countries; (ii) establish training linkages

  7. Thermodynamic analysis of heat recovery steam generator in combined cycle power plant

    Directory of Open Access Journals (Sweden)

    Ravi Kumar Naradasu

    2007-01-01

    Full Text Available Combined cycle power plants play an important role in the present energy sector. The main challenge in designing a combined cycle power plant is proper utilization of gas turbine exhaust heat in the steam cycle in order to achieve optimum steam turbine output. Most of the combined cycle developers focused on the gas turbine output and neglected the role of the heat recovery steam generator which strongly affects the overall performance of the combined cycle power plant. The present paper is aimed at optimal utilization of the flue gas recovery heat with different heat recovery steam generator configurations of single pressure and dual pressure. The combined cycle efficiency with different heat recovery steam generator configurations have been analyzed parametrically by using first law and second law of thermodynamics. It is observed that in the dual cycle high pressure steam turbine pressure must be high and low pressure steam turbine pressure must be low for better heat recovery from heat recovery steam generator.

  8. Adherence to combined Lamivudine + Zidovudine versus individual components: a community-based retrospective medicaid claims analysis.

    Science.gov (United States)

    Legorreta, A; Yu, A; Chernicoff, H; Gilmore, A; Jordan, J; Rosenzweig, J C

    2005-11-01

    Adherence to a fixed dose combination of dual nucleoside antiretroviral therapy was compared between human immunodeficiency virus (HIV)-infected patients newly started on a fixed dosed combination of lamivudine (3TC) 150 mg/zidovudine (ZDV) 300 mg versus its components taken as separate pills. Medicaid pharmacy claims data were used for analyses. To examine the association between treatment group and medication adherence, three types of multivariate regressions were employed. In addition, all regressions were conducted for the whole population using data from 1995 to 2001 as well as a subpopulation, which excluded data prior to September 1997. Model covariates included patient characteristics, healthcare utilization, and non-study antiretroviral therapy use. The likelihood of > or =95% adherence among patients on combination therapy was three times greater than patients taking 3TC and ZDV in separate pills. Also, combination therapy patients had on average 1.4 fewer adherence failures per year of follow-up and nearly double the time to adherence failure compared to the separate pills group. Consistency among study results suggests that fixed dose combination therapies such as lamivudine (3TC) 150 mg/ zidovudine (ZDV) 300 mg should be considered when prescribing HIV treatment that includes an appropriate dual nucleoside.

  9. Analysis of switch and examine combining with post-examining selection in cognitive radio

    Science.gov (United States)

    Agarwal, Rupali; Srivastava, Neelam; Katiyar, Himanshu

    2018-06-01

    To perform spectrum sensing in fading environment is one of the most challenging tasks for a CR system. Diversity combining schemes are used to combat the effect of fading and hence detection probability of CR gets improved. Among many diversity combining techniques, switched diversity offers one of the lowest complexity solutions. The receiver embedded with switched diversity looks for an acceptable diversity path (having signal to noise ratio (SNR) above the required threshold) to receive the data. In conventional switch and examine combining (SEC) scheme, when no acceptable path is found after all the paths are examined, the receiver randomly chooses an unacceptable path. Switch and examine combining with post-examining selection (SECp) is a modified version of conventional SEC. In SECp, the conventional SEC scheme is altered in a way that it selects the best path when no acceptable path is found after all paths have been examined. In this paper, formula for probability of detection ( ?) is derived using SECp and SEC diversity combining technique over Rayleigh fading channel. Also the performance of SECp is compared with SEC and no diversity case. Performance comparison is done with the help of SNR vs. ? and complementary receiver operating characteristic curves.

  10. Ongoing Analyses of Rocket Based Combined Cycle Engines by the Applied Fluid Dynamics Analysis Group at Marshall Space Flight Center

    Science.gov (United States)

    Ruf, Joseph H.; Holt, James B.; Canabal, Francisco

    2001-01-01

    This paper presents the status of analyses on three Rocket Based Combined Cycle (RBCC) configurations underway in the Applied Fluid Dynamics Analysis Group (TD64). TD64 is performing computational fluid dynamics (CFD) analysis on a Penn State RBCC test rig, the proposed Draco axisymmetric RBCC engine and the Trailblazer engine. The intent of the analysis on the Penn State test rig is to benchmark the Finite Difference Navier Stokes (FDNS) code for ejector mode fluid dynamics. The Draco analysis was a trade study to determine the ejector mode performance as a function of three engine design variables. The Trailblazer analysis is to evaluate the nozzle performance in scramjet mode. Results to date of each analysis are presented.

  11. An engineering-economic analysis of combined heat and power technologies in a (mu)grid application

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, Owen; Ouaglal, Boubekeur; Bartholomew, Emily; Marnay, Chris; Bourassa, Norman

    2002-03-01

    This report describes an investigation at Ernesto Orlando Lawrence Berkeley National Laboratory (Berkeley Lab) of the potential for coupling combined heat and power (CHP) with on-site electricity generation to provide power and heating, and cooling services to customers. This research into distributed energy resources (DER) builds on the concept of the microgrid (mGrid), a semiautonomous grouping of power-generating sources that are placed and operated by and for the benefit of its members. For this investigation, a hypothetical small shopping mall (''Microgrid Oaks'') was developed and analyzed for the cost effectiveness of installing CHP to provide the mGrid's energy needs. A mGrid consists of groups of customers pooling energy loads and installing a combination of generation resources that meets the particular mGrid's goals. This study assumes the mGrid is seeking to minimize energy costs. mGrids could operate independently of the macrogrid (the wider power network), but they are usually assumed to be connected, through power electronics, to the macrogrid. The mGrid in this study is assumed to be interconnected to the macrogrid, and can purchase some energy and ancillary services from utility providers.

  12. Environmental impact efficiency of natural gas combined cycle power plants: A combined life cycle assessment and dynamic data envelopment analysis approach.

    Science.gov (United States)

    Martín-Gamboa, Mario; Iribarren, Diego; Dufour, Javier

    2018-02-15

    The energy sector is still dominated by the use of fossil resources. In particular, natural gas represents the third most consumed resource, being a significant source of electricity in many countries. Since electricity production in natural gas combined cycle (NGCC) plants provides some benefits with respect to other non-renewable technologies, it is often seen as a transitional solution towards a future low‑carbon power generation system. However, given the environmental profile and operational variability of NGCC power plants, their eco-efficiency assessment is required. In this respect, this article uses a novel combined Life Cycle Assessment (LCA) and dynamic Data Envelopment Analysis (DEA) approach in order to estimate -over the period 2010-2015- the environmental impact efficiencies of 20 NGCC power plants located in Spain. A three-step LCA+DEA method is applied, which involves data acquisition, calculation of environmental impacts through LCA, and the novel estimation of environmental impact efficiency (overall- and term-efficiency scores) through dynamic DEA. Although only 1 out of 20 NGCC power plants is found to be environmentally efficient, all plants show a relatively good environmental performance with overall eco-efficiency scores above 60%. Regarding individual periods, 2011 was -on average- the year with the highest environmental impact efficiency (95%), accounting for 5 efficient NGCC plants. In this respect, a link between high number of operating hours and high environmental impact efficiency is observed. Finally, preliminary environmental benchmarks are presented as an additional outcome in order to further support decision-makers in the path towards eco-efficiency in NGCC power plants. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. A Meta-Analysis of Arsenic Trioxide Combined with Transcatheter Arterial Chemoembolization for Treatment of Primary Hepatic Carcinoma

    Directory of Open Access Journals (Sweden)

    Ling He

    2016-01-01

    Full Text Available Primary hepatic carcinoma (PHC is one of the most common malignant tumours in the world. More and more research has shown that As2O3 combined with TACE has a good curative effect in treating PHC. The objectives of this study were to evaluate the therapeutic efficacy and safety of As2O3 combined with TACE in treating PHC. The CNKI, VIP, Wanfang, PubMed, and Cochrane databases were searched from their inception until December 2015. Randomized controlled trials (RCTs comparing As2O3 combined with TACE versus TACE alone in treating PHC were identified. Stata SE 12.0 was used for data analysis. 17 RCTs with 1055 patients were included. Meta-analysis showed that, compared with TACE alone, As2O3 combined with TACE showed significant effects in improving the clinical efficacy rate (P<0.01, decreasing the value of alpha-fetoprotein (P<0.01, increasing the one-year survival rate (P<0.01, and improving the quality of life of PHC patients (P<0.01. Fifteen studies had mentioned adverse events, but no serious adverse effects were reported in any of the included trials. In conclusion, As2O3 combined with TACE therapy appears to be potentially effective in treating PHC and is generally safe. However, further studies with rigorous designs trials and multiregional cooperation trials are needed.

  14. Tamsulosin combined with solifenacin versus tamsulosin monotherapy for male lower urinary tract symptoms: a meta-analysis.

    Science.gov (United States)

    Gong, Mancheng; Dong, Wenjing; Huang, Guiying; Gong, Zhaoyang; Deng, Decheng; Qiu, Shaopeng; Yuan, Runqiang

    2015-01-01

    To evaluate the efficacy and safety of tamsulosin and solifenacin combination therapy compared with tamsulosin monotherapy for male lower urinary tract symptoms (LUTS). We identified all eligible studies that compared tamsulosin and solifenacin combination therapy with tamsulosin monotherapy for male LUTS (up to January 2015). The fixed- or random-effects model was selected depending on the proportion of heterogeneity. Seven articles were identified as eligible for this meta-analysis, with a total of 3063 participants. Synthetic data showed combination therapy had significant improvements in Storage International Prostate Symptom Score (WMD = -0.60; 95% CI: -0.81 to -0.38, P tamsulosin and solifenacin combined therapy group (30.82%) was similar to the tamsulosin monotherapy group (25.75%). Acute urinary retention was seldom reported in the studies and no clinically significant changes regarding Qmax were showed in our meta-analysis. Tamsulosin and solifenacin combination therapy may be a reasonable option for male LUTS patients, especially for those who have significant storage symptoms. However, PVR should be measured during treatment to assess the increase in PVR or the incidence of AUR.

  15. Crisis meeting

    CERN Multimedia

    Staff Association

    2014-01-01

      To all CERN staff: your rights are at risk ! We invite you to come to a crisis meeting on Wednesday 2nd April at 10:30 a.m., Auditorium, Main Building, Meyrin site. Your presence is crucial, we are ALL concerned !

  16. Crisis meeting

    CERN Multimedia

    Staff Association

    2015-01-01

    To all CERN staff: your rights are at risk! We invite you to come to a crisis meeting on Thursday 7th May 2015 at 9 a.m., Auditorium, Main Building, Meyrin site. Your presence is crucial, we are ALL concerned!

  17. ACCU MEETING

    CERN Multimedia

    Chris Onions

    2002-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 4 December 2002 At 9:15 a.m. in room 60-6-002 Chairman's remarks Adoption of the agenda Minutes of the previous meeting Matters arising News from the CERN Management Fellows, Associates and Summer Student Programmes Particle Data Book distribution Revoking Computer accounts Equipment insurance on site Reports from ACCU representatives on other committees Users' Office news Any Other Business Dates for meetings in 2003 Agenda for the next meeting Anyone wishing to raise any points under item 12 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch   ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (74837...

  18. ACCU MEETING

    CERN Multimedia

    Chris Onions (Secretary)

    2001-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 5 December 2001 At 9:15 a.m. in room 60-6-002 1. Chairman's remarks 2. Adoption of the agenda 3. Minutes of the previous meeting 4. Matters arising 5. News from the CERN Management 6. Housing 7. Restaurant Surveillance Committee 8. Users' Office news 9. Election of ACCU chairman 10. Any Other Business 11. Dates for meetings in 2002 12. Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria  W. Adam  (71661) Belgium  G. Wilquet  (74664) Bulgaria  R. Tzenov  (77958) Czech Republic  P. Závada&am...

  19. ACCU MEETING

    CERN Multimedia

    Chris Onions (Secretary)

    2001-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 5 December 2001 At 9:15 a.m. in room 60-6-002 1. Chairman's remarks 2. Adoption of the agenda 3. Minutes of the previous meeting 4. Matters arising 5. News from the CERN Management 6. Housing 7. Restaurant Surveillance Committee 8. Users' Office news 9. Election of ACCU chairman 10. Any Other Business 11. Dates for meetings in 2002 12. Agenda for the next meetingAnyone wishing to raise any points under item 10 is invited to send them to the Chairman in writing or by e-mail to Christopher.Onions@cern.ch ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets): Austria W. Adam (71661) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958) Czech Republic P. Závada (75877) Denmark A. Waananen (75941) Finland A. Kiiskinen (79387) Fr...

  20. ACCU MEETING

    CERN Multimedia

    2000-01-01

    DRAFT Agenda for the meeting to be held on Wednesday 6 December 2000 At 10 a.m. in the 6th floor Conference Room, Main Building Chairman's remarks Adoption of the agenda News from the CERN Management Minutes of the previous meeting Matters arising Equal Opportunities at CERN The Summer Student programme CERN Programme for Physics High School Teachers Users' Office News Any Other Business Dates for Meetings in 2001 Agenda for the next meeting Anyone wishing to raise any points under item 10 is invited to send them to the Secretary in writing via the CERN Users' Office or by e-mail to Christopher.Onions@cern.ch Chris Onions (Secretary) ACCU is the forum for discussion between the CERN Management and the representatives of CERN Users to review the practical means taken by CERN for the work of Users of the Laboratory. The User Representatives to ACCU are (CERN internal telephone numbers in brackets) :   Austria G. Neuhofer (74094) Belgium G. Wilquet (74664) Bulgaria R. Tzenov (77958)...